[Immunologic aspects of disorders of neuromuscular transmission. 2. Experimental autoimmune myasthenia gravis and the Lambert-Eaton myasthenic syndrome].
This paper describes two condition caused by disfunction of neuromuscular transport: experimental autoimmune myasthenia gravis (EAMG) and Lambert-Eaton myasthenic syndrome (LEMS). EAMG can be caused by immunization with acetylcholine receptors (AChR). As in myasthenia gravis, anti-AChR antibodies reduce the number of these receptors, which impedes normal neuromuscular transmission. LEMS patients have normal AChR function: however there is a disfunction of acetylcholine release from the presynaptic terminals. This is due to the formation of antibodies against the voltage gated calcium channels on the presynaptic nerve terminals.
Zavod za fiziologiju Medicinskog fakulteta Sveucilista u Zagrebu.
I
I
Andreis
T J
TJ
Lovnićki
N
N
Beara
M
M
Taradi
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000276:immunology* / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000276:immunology* / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000276:immunology; D009435:Synaptic Transmission
D011950:Receptors, Cholinergic
Imunoloski aspekti poremećaja neuromuskularnog prijenosa. 2. Eksperimentalna autoimuna miastenja gravis i Lambert-Eatonov miastenicni sindrom.