Speech motor control disorder after HIV infection.
We examined the clinical characteristics of six right-handed patients who developed speech motor control disorders after human immunodeficiency virus (HIV) infection. They exhibited an ataxic dysarthria, characterized by irregular articulatory breakdowns in consonant and vowel timing; were slow in timed decision-making tasks; and had impaired procedural learning. Other aspects of the neurologic examination revealed signs of diffuse CNS involvement including action-intention tremors, ataxic gait, and release signs. None developed HIV-associated dementia during 1 year of follow-up. Motor speech control disorder appears to be related to a cerebellar dysfunction.
Lopez
O L
OL
Department of Neurology, School of Medicine, University of Pittsburgh, PA.
Becker
J T
JT
Dew
M A
MA
Banks
G
G
Dorst
S K
SK
McNeil
M
M
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D008297:Male; D009043:Motor Activity; D009483:Neuropsychological Tests; D013064:Speech Disorders / Q000209:etiology* / Q000503:physiopathology