A unique mutation of glycoprotein gene of the attenuated RC-HL strain of rabies virus, a seed virus used for production of animal vaccine in Japan.
Although the RC-HL strain of rabies virus is avirulent in adult mice, the amino acid at position 333 of its G protein is arginine, which is thought to be necessary for virulence in adult mice upon intracerebral inoculation of the virus. This result suggests that besides arginine at position 333, some other positions of G protein might also be involved in determining the virulence of rabies virus.
Ito
H
H
Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, Japan.
Minamoto
N
N
Watanabe
T
T
Goto
H
H
Rong
L T
LT
Sugiyama
M
M
Kinjo
T
T
Mannen
K
K
Mifune
K
K
Konobe
T
T
D000595:Amino Acid Sequence; D000956:Antigens, Viral; D001483:Base Sequence; D006023:Glycoproteins / Q000235:genetics*; D007564:Japan; D008969:Molecular Sequence Data; D009154:Mutation; D016366:Open Reading Frames / Q000235:genetics; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000096:biosynthesis*; D011820:Rabies virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D014613:Vaccines, Attenuated; D014759:Viral Envelope Proteins / Q000235:genetics*; D014774:Virulence
D000956:Antigens, Viral; D006023:Glycoproteins; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus