Chronic gliclazide treatment affects basal and post-ischemic cardiac function in diabetic rats.
1. A 6-week gliclazide treatment improved left ventricular developed pressure and left ventricular end-diastolic pressure, left ventricular pressure-rate products in isolated working hearts from streptozotocin-induced diabetic rats. 2. Post-ischemic recovery in heart rate, left ventricular developed pressure, left ventricular end-diastolic pressure, left ventricular pressure-rate products and cardiac work were also shown in gliclazide-treated diabetic rats. 3. Gliclazide treatment did not modify the degree of insulinopenia and hyperglycemia, nor the myocardial energy metabolism during ischemia-reperfusion. 4. The results suggest that the gliclazide treatment has a cardioprotective effect on basal and post-ischemic cardiac functions of chronic diabetes.
Shimabukuro
M
M
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Nagamine
F
F
Murakami
K
K
Oshiro
K
K
Mimura
G
G
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005907:Gliclazide / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
D007773:Lactates; D019344:Lactic Acid; D013311:Streptozocin; D000255:Adenosine Triphosphate; D005907:Gliclazide