[A prospective histologic and immunohistochemical study of the liver in blood donors who are asymptomatic chronic carriers of HBs antigens. Apropos of 34 cases].
The authors report a prospective study of 34 chronic HBs Ag carriers detected among a cohort of 9029 blood donors. Liver biopsy performed in all cases revealed a normal liver in 5 cases (14.7%), non-specific lesions in the form of fatty infiltration or mild portal inflammation in 3 cases (8.8%), chronic persistent hepatitis (CPH) in 21 cases (61.7%) (mild in 19 and moderate in 2) and chronic active hepatitis (CAH) in 5 cases (14.6%) (mild in 1 and moderate in 4). Liver function tests were abnormal in 28.8% of patients with CPH and 20% of those with CAH. Histologic activity index was calculated and was more than 6 in 40% of CAH and 6 or less in CPH and non-specific lesions. Immunohistochemical study revealed cytoplasmic labelling for HBs Ag in 82.4 per cent of cases and nuclear labelling for HBc Ag in 11.4% of cases with a heterogeneous and non-regular pattern affecting all or part of the cytoplasm, single or clusters of hepatocytes or even sheets of hepatocytes.
Ben Rejeb
A
A
Service d'Anatomie et de Cytologie pathologique, Hôpital militaire de Tunis, Montfleury, Tunisie.
Khediri
F
F
Ebdelli
N
N
Bouali
R
R
Ben Ahmed
F
F
D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D001782:Blood Donors; D002353:Carrier State; D015331:Cohort Studies; D003593:Cytoplasm / Q000276:immunology; D005234:Fatty Liver / Q000276:immunology / Q000473:pathology; D006505:Hepatitis / Q000276:immunology / Q000473:pathology; D006509:Hepatitis B / Q000276:immunology* / Q000473:pathology*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000097:blood; D006521:Hepatitis, Chronic / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000201:enzymology / Q000276:immunology* / Q000473:pathology*; D008297:Male; D011446:Prospective Studies
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Etude histologique et immuno-histochimique prospective du foie chez des donneurs de sang porteurs chroniques asymptomatiques de l'antigène HBs. A propos de 34 cas.