Lymphoglandular bodies in lymphoid lesions and non-lymphoid round cell tumours: a quantitative assessment.
Lymphoglandular bodies (cytoplasmic fragments) were counted in 10 high power fields (HPF) of the smears in 35 cases of non-Hodgkin lymphoma (NHL), 26 Hodgkin's disease (HD), 36 reactive lymphadenitis, 24 non-lymphoid round cell tumors, and 20 cases of secondaries in lymph nodes. The number of lymphoglandular bodies in both May-Grünwald-Giemsa (MGG) and hematoxylin-eosin (H&E) stained smears in NHL, HD, and reactive lymphadenitis were significantly higher compared to non-lymphoid round cell tumors (P < 0.001). In H&E stained smear 92.5% of NHL, 86.2% of reactive lymph nodes, and 66.7% of HD cases had > 100 lymphoglandular bodies per 10 HPF. In MGG stained smears 100% NHL, 89.7% of reactive lymphadenitis, and 66.7% of HD cases contained > 100 lymphoglandular bodies per 10 HPF. On the other hand only 4.8% of non-lymphoid round cell tumors crossed this level in both H&E stained and MGG stained smears. Number of lymphoglandular bodies was also significantly higher in MGG stained smears compared to H&E stained smears (P < 0.05 to < 0.01) and in fine-needle aspiration (FNA) smears compared to imprint smears (P < 0.01 to < 0.001) in cases of NHL, HD, and reactive lymphadenitis.
The Cytology-Histopathology Unit, Mubarak Al-Kabeer Hospital, Kuwait.
I M
IM
Francis
D K
DK
Das
N A
NA
al-Rubah
S K
SK
Gupta
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008206:Lymphatic Diseases / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008223:Lymphoma / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000648:ultrastructure