C-fos expression after single and kindled audiogenic seizures in Wistar rats.
In naive Wistar rats susceptible to sound, a single audiogenic seizure induced the expression of c-fos in the subcortical auditory nuclei whereas the forebrain was almost completely devoid of any labelling. After kindling of audiogenic seizures by 40 daily exposures to sound, the seizure induced a strong c-fos expression in the amygdala, the piriform cortex, the hippocampus and the neocortex. These results confirm: (1) that audiogenic seizures are brain-stem seizures related to dysfunction of auditory pathways, and (ii) that kindling of audiogenic seizures recruits forebrain and limbic structures into the seizure network.
INSERM U 398, Hôpitaux Universitaires de Strasbourg, France.
S
S
Simler
E
E
Hirsch
L
L
Danober
J
J
Motte
M
M
Vergnes
C
C
Marescaux
D000161:Acoustic Stimulation; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D015870:Gene Expression; D016762:Genes, fos; D006624:Hippocampus / Q000378:metabolism; D007245:Inferior Colliculi / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D016548:Prosencephalon / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos