IGF-I of serum and vitreous fluid in patients with diabetic proliferative retinopathy.
Vitreous fluid and serum were obtained at the time of vitrectomy from 15 subjects with diabetic proliferative retinopathy and 6 control subjects. The mean serum IGF-I (IGF-I level: 1 nM/l = 7.7 ng/ml) concentrations were 15.40 +/- 4.97 nM/l in controls and 16.24 +/- 4.32 nM/l in diabetic patients. The mean vitreous IGF-I concentration was 1.05 +/- 0.30 nM/l in controls and 0.91 +/- 0.50 nM/l in diabetic patients. There were no significant differences between the two groups, and serum IGF-I concentrations were not correlated with vitreous IGF-I concentrations in the patients with diabetic proliferative retinopathy. These data suggest that IGF-I may not be a risk factor for the development of proliferative diabetic retinpathy.
Lee
H C
HC
Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Lee
K W
KW
Chung
C H
CH
Chung
Y S
YS
Lee
E J
EJ
Lim
S K
SK
Kim
K R
KR
Huh
K B
KB
Lee
S C
SC
Kwon
O W
OW
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003930:Diabetic Retinopathy / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D011863:Radioimmunoassay; D012016:Reference Values; D014821:Vitrectomy; D014822:Vitreous Body / Q000737:chemistry*
D007334:Insulin-Like Growth Factor I