[Experimental study of therapeutic efficacy of plasmapheresis in acute radiation injury].
In experiments with dogs exposed to 2.9 Gy (LD80/45) it was found that plasmapheresis treatment 4-6 h after irradiation reduce the severity of the radiation sickness clinical manifestations and post-radiation toxemia thus increasing the rate of animal survival up to 60%. Sham plasmapheresis included all the manipulations of plasmapheretic treatment except plasma substitution and had no detoxication effect and did not affect the irradiated animals survival. This is evidence for leading role of detoxication in the mechanisms of the therapeutic action of plasmapheresis in acute irradiation.
Legeza
V I
VI
Abdul'
Iu A
IuA
Chigareva
N G
NG
Petkevich
N V
NV
Miasoedov
A F
AF
Andriukhin
V I
VI
Artemenko
A G
AG
D000208:Acute Disease; D000818:Animals; D001772:Blood Cell Count / Q000528:radiation effects; D002464:Cell Migration Inhibition; D004285:Dogs; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010956:Plasmapheresis; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000628:therapy*; D014916:Whole-Body Irradiation
D008315:Malondialdehyde
Eksperimental'noe issledovanie terapevticheskoĭ éffektivnosti plazmafereza pri ostrom radiatsionnom porazhenii.