Neuropharmacology of 5-hydroxytryptamine1B/D receptor ligands.
In spite of a lack of compounds acting selectively at the 5-hydroxytryptamine (5-HT)1B and 5-HT1D receptor subtypes, by cross-relating the available data, this review attempts to tentatively assign behavioural and other in vivo correlates of these receptor subtypes. In addition, a summary of data from microdialysis studies is included to develop an integrated view. Finally, a suggestion is made as to the possible pathophysiological consequences of 5-HT1D receptor dysfunction in man.
Chopin
P
P
Division of Neurobiology I, Pierre Fabre Research Center, Castres, France.
Moret
C
C
Briley
M
M
D000818:Animals; D001007:Anxiety / Q000517:prevention & control; D001522:Behavior, Animal / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008024:Ligands; D017551:Microdialysis; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects* / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects
D008024:Ligands; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists