Genetically determined sparteine oxidation polymorphism in a Polish population.
The genetic oxidation polymorphism was determined in 160 healthy Polish volunteers from the south-west of Poland (Wrocław region), using sparteine as a model drug. The results of a Polish population study revealed a bimodal distribution of the sparteine metabolic ratio and showed the existence of two oxidation phenotypes designated as extensive and poor metabolizers. The frequency of poor metabolizers in our study (8.8%) compares well with most results of poor oxidation metabolizers in Caucasian populations.
K
K
Orzechowska-Juzwenko
J
J
Pawlik
P
P
Niewiński
P
P
Milejski
J
J
Dembowski
J
J
Turek
A
A
Goździk
L
L
Swiebodzki
Z
Z
Hora
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011044:Poland; D011110:Polymorphism, Genetic; D013034:Sparteine / Q000378:metabolism / Q000493:pharmacokinetics*
D013034:Sparteine