Antimicrobial effects of new 1-(1,2,4-triazol-1-yl)-acetanilides.
Fourteen synthetically prepared 1-(1,2,4-triazol-1-yl)acetanilides were tested for antimicrobial effect. None of the prepared derivatives influenced the B. subtilis, P. fluorescens nor the tested yeasts. Only the derivatives with substituents in positions para or ortho and para were biologically effective. The widest antimicrobial spectrum was manifested by the pentachloro derivative, which was effective with G+ and G- bacteria and with filamentous fungi.
Department of Microbiology, Biochemistry and Biology, Faculty of Chemical Technology, Slovak Technical University, Bratislava.
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Jantová
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Hudecová
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Stankovský
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Spirková
D000083:Acetanilides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000083:Acetanilides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents