Weight gain as a function of smoking cessation and 2-mg nicotine gum use among middle-aged smokers with mild lung impairment in the first 2 years of the Lung Health Study.
The extent and predictors of weight change were assessed among sustained nonsmoking special intervention participants in the Lung Health Study. The intervention included a 12-session group program and 2-mg nicotine gum. At 12 months, female sustained quitters (SQs; n = 248) had gained a mean of 8.4% (5.3 kg) of their baseline weight, whereas male SQs (n = 443) had gained 6.7% (5.5 kg). By 24 months, female SQs had gained 9.8% of their baseline weight compared with 6.9% for men. Nicotine gum usage delayed a portion of the weight gain. Multiple regression analysis showed that weight gain at 12 months was associated with a higher baseline salivary cotinine level, a lower baseline body mass index, drinking less alcohol per week, and a lower cotinine level at 12 months (indicating less or no nicotine gum use). We conclude that moderate weight gain is a long-term consequence of smoking cessation--a portion of which can be delayed with 2-mg nicotine gum.
Nides
M
M
Department of Pulmonary and Critical Care Medicine, University of California, Los Angeles 90024.
Rand
C
C
Dolce
J
J
Murray
R
R
O'Hara
P
P
Voelker
H
H
Connett
J
J
D000328:Adult; D018679:Cholinergic Agonists / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000534:rehabilitation; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011109:Polymethacrylic Acids / Q000627:therapeutic use*; D011145:Polyvinyls / Q000627:therapeutic use*; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D016540:Smoking Cessation / Q000523:psychology*; D061485:Tobacco Use Cessation Devices; D015430:Weight Gain
D018679:Cholinergic Agonists; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D009538:Nicotine