Biological activities of lipopolysaccharide isolated from Vibrio cholerae O139, a new epidemic strain for recent cholera in Indian subcontinent.
Biological activities of lipopolysaccharide (LPS) isolated from Vibrio cholerae O139, a new causative agent for recent cholera epidemic in Indian subcontinent, were investigated in comparison with those of LPS from O1 V. cholerae. V. cholerae O139 LPS exerted mitogenic activity, lethal toxicity and Shwartzman reaction to the same extent as those observed for O1 V. cholerae LPS, although these activities except for lethal toxicity were obviously lower than those of Salmonella typhimurium LT-2 LPS used as a reference. It was, therefore, suggested that O139 LPS does not contribute to the high infective and pathogenic potentials of the V. cholerae O139 strain as in the case of O1 V. cholerae.
Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
T
T
Shimizu
Y
Y
Yanagihara
Y
Y
Isshiki
Y
Y
Kawamata
S
S
Kondo
K
K
Hisatsune
D000818:Animals; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007194:India / Q000453:epidemiology; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000633:toxicity*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000139:chemically induced / Q000473:pathology; D013154:Spleen / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D014734:Vibrio cholerae / Q000737:chemistry* / Q000145:classification / Q000472:pathogenicity
D008070:Lipopolysaccharides; D004247:DNA; D013936:Thymidine