Non-fasting factor VII coagulant activity (FVII:C) increased by high-fat diet.
Preliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVII:Am). The ratio FVII:Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII:Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet. The findings suggest that high-fat diets increase non-fasting FVII:C, and consequently may be associated with increased risk of thrombosis.
Department of Clinical Chemistry, Ribe County Hospital, Esbjerg, Denmark.
E M
EM
Bladbjerg
P
P
Marckmann
B
B
Sandström
J
J
Jespersen
D000328:Adult; D000941:Antigens / Q000378:metabolism*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000494:pharmacology*; D005167:Factor VII / Q000378:metabolism*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male
D000941:Antigens; D004041:Dietary Fats; C042580:factor VII clotting antigen; D005167:Factor VII