A comparison of soft-tissue substitutes.
The fate of the Zyderm II, Zyplast, Vicryl, and chromic gut was histologically examined up to 1 year following subcutaneous implantation into rats. Our data demonstrated both Zyderm II and Zyplast to be inert materials without inflammatory response; there was no difference in long-term persistence between these two collagens. Both Vicryl and chromic gut implants caused an intense inflammatory response at 1 month, and Vicryl was completely resorbed before 6 months. The degree of inflammation associated with chromic gut diminished over time, and approximately 67% of the material persisted without reaction up to 1 year.
Division of Plastic Surgery, Baylor College of Medicine, Houston, TX 77030.
H E
HE
Ozgentaş
A
A
Pindur
M
M
Spira
B
B
Liu
S
S
Shenaq
D000818:Animals; D001672:Biocompatible Materials; D002398:Catgut; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology*; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D011098:Polyglactin 910; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D001672:Biocompatible Materials; C048470:glutaraldehyde-cross-linked collagen; D011098:Polyglactin 910; D003094:Collagen