Similar activity of chlorambucil and its spermidine conjugate in the mouse bone marrow micronucleus assay.
The spermidine conjugate of the human carcinogen and cancer therapeutic agent chlorambucil has been evaluated in the mouse bone marrow micronucleus assay. It showed a similar level of activity to that of chlorambucil, indicating that the superior ability of the conjugate to cross-link DNA in vitro is not expressed as enhanced genotoxicity in vivo.
Ashby
J
J
Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Tinwell
H
H
Weaver
R
R
Cullis
P M
PM
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002699:Chlorambucil / Q000031:analogs & derivatives / Q000633:toxicity*; D003432:Cross-Linking Reagents / Q000633:toxicity*; D004249:DNA Damage / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D013095:Spermidine; D013329:Structure-Activity Relationship
D003432:Cross-Linking Reagents; D002699:Chlorambucil; D013095:Spermidine