[Biochemistry of bone matrix].
Bone matrix proteins can be divided into several groups according to their function; structural proteins, cell adhesive molecules, growth factors, proteinases and others. 1) Type I collagen is a major structural protein. 2) Osteopontin and bone sialoprotein (BSP) are RGD-containing cell adhesive proteins. Cadherins, OSF-2 and MGP also act as cell adhesive molecules in cell to cell or cell to matrix signal transition systems. 3) BMPs, TGF-b, IGFs, FGFs and PDGF are bone growth factors associated to bone matrix. 4) Collagenases and cathepsins are well known organic bone matrix degrading enzymes.
Hoechst Japan Limited, Pharma Research & Development Division.
Y
Y
Otawara-Hamamoto
D000818:Animals; D001857:Bone Matrix / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D002403:Cathepsins / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D003094:Collagen / Q000502:physiology; D017364:Collagenases / Q000502:physiology; D006801:Humans; D012795:Sialoglycoproteins / Q000502:physiology
D015815:Cell Adhesion Molecules; D012795:Sialoglycoproteins; D003094:Collagen; D002403:Cathepsins; D017364:Collagenases