Papillary thyroid carcinoma after total body irradiation.
Two children developed papillary thyroid carcinoma after allogeneic bone marrow transplantation (BMT) probably due to radiotherapy during remission and pretransplantation conditioning. Establishing a relationship between the cellular thyroid stimulating hormone (TSH) effect and development of carcinoma in cases with high serum TSH concentrations is difficult. After BMT, patients should be regularly followed up with thyroid ultrasound and, when nodularity is found, fine needle aspiration and/or open biopsy are recommended.
Department of Paediatric Haematology and Oncology, S Gerardo Hospital, University of Milan, Monza, Italy.
C
C
Uderzo
M T
MT
van Lint
A
A
Rovelli
G
G
Weber
M R
MR
Castellani
A
A
Bacigalupo
N
N
Masera
A
A
Cohen
D016026:Bone Marrow Transplantation; D002291:Carcinoma, Papillary / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D013964:Thyroid Neoplasms / Q000209:etiology*; D013972:Thyrotropin / Q000097:blood; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D013972:Thyrotropin