Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children.
We report six cases of protein S deficiency secondary to varicella. Five cases were complicated by thrombotic and vascular events, namely purpura fulminans and necrotic vasculitis, deep vein thrombosis and stroke. Two cases were associated with protein C deficiency and one case revealed a heterozygous factor XII deficiency. The underlying mechanism of this acquired protein S deficiency is unclear but could be related to a direct effect of zoster virus.
Laboratoire Central d'Hématologie, CHU Robert-Debré, Reims, France.
P
P
Nguyên
J
J
Reynaud
P
P
Pouzol
M
M
Munzer
O
O
Richard
P
P
François
D002644:Chickenpox / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005175:Factor XII Deficiency / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D020151:Protein C Deficiency; D018455:Protein S Deficiency / Q000150:complications*; D011693:Purpura / Q000150:complications*; D013927:Thrombosis / Q000150:complications*; D013997:Time Factors; D014657:Vasculitis / Q000150:complications*