The effect of transurethral light on the canine prostate after sensitization with the photosensitizer tin (II) etiopurpurin dichloride: a pilot study.
A pilot study was undertaken to determine the effect of transurethral light on photosensitized periurethral prostatic tissue in the dog. Initial studies demonstrated that a sufficient level of the photosensitizer tin (II) etiopurpurin dichloride, SnET2, was present in the canine prostate 24 hours after intravenous administration to create a photodynamic effect. Gross and histologic examination of SnET2 photosensitized prostates treated transurethrally with 285 joules per cm. of red light (660 nm.) showed hemorrhagic necrosis as much as 1 cm. from the urethral wall. Three weeks after treatment, circumferential glandular atrophy was evident within the treatment area. The urethral mucosa, which was histologically absent at the 48-hour interval, regenerated by 3 weeks. Transurethral photodynamic treatment of the prostate is feasible, and its use for the treatment of benign prostatic hyperplasia warrants further investigation.
Department of Urology, Medical College of Ohio, Toledo 43699-0008.
S H
SH
Selman
R W
RW
Keck
D000818:Animals; D004285:Dogs; D005240:Feasibility Studies; D008027:Light; D008297:Male; D010865:Pilot Projects; D011166:Porphyrins / Q000032:analysis / Q000494:pharmacology; D011467:Prostate / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D011838:Radiation-Sensitizing Agents / Q000032:analysis / Q000494:pharmacology*; D014521:Urethra
D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C063166:tin etiopurpurin