Reversible functional asplenia. Autoimmune hemolytic anemia with thrombocytopenia in chronic lymphocytic leukemia.
An enlarged spleen failed to accumulate Tc-99m-labeled phytate, but it showed normal perfusion and uptake of labeled and heat-denatured red blood cells. A blood cell count demonstrated moderately low hemoglobin and hematocrit levels and a markedly low platelet count, and results of direct Coombs' and antiplatelet-antibody (IgG) tests were positive. Steroid therapy resulted in normal splenic function. This case demonstrates reversible functional asplenia caused by reticuloendothelial dysfunction secondary to pure splenic chronic lymphocytic leukemia.
Department of Nuclear Medicine, Gunma University, School of Medicine, Japan.
T
T
Hirano
K
K
Tomiyoshi
H
H
Take
N
N
Watanabe
N
N
Oriuchi
T
T
Inoue
M
M
Naruse
K
K
Endo
D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000209:etiology*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D017254:Leukemic Infiltration / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011239:Prednisolone / Q000627:therapeutic use; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013154:Spleen / Q000000981:diagnostic imaging* / Q000473:pathology; D013163:Splenomegaly / Q000000981:diagnostic imaging* / Q000209:etiology; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology*
D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid; D011239:Prednisolone; D013670:Sodium Pertechnetate Tc 99m