Effects of sedatives and their solvents on the neutrophil granulocyte function.
We have examined the effects of commercially available preparations and drug-free solvents of Midazolam (Dormicum) and Propofol (Disoprivan) by N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced polymorphonuclear cell (PMN) chemiluminescence system. In the case of propofol and drug-free solvent, PMN chemiluminescence was suppressed. With Midazolam, only the active drug depressed PMN chemiluminescence.
Department of Anesthesiology, Tongji Hospital, Tongji Medical University, Wuhan.
Y K
YK
Tian
M
M
Weiss
M
M
Schneider
D006801:Humans; D008163:Luminescent Measurements; D008874:Midazolam / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010587:Phagocytosis; D015742:Propofol / Q000494:pharmacology*; D016897:Respiratory Burst; D012997:Solvents; D013481:Superoxides
D012997:Solvents; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008874:Midazolam; D015742:Propofol