Poland anomaly after in vitro fertilization.
OBJECTIVE
To describe an extremely rare anomaly in an infant born after IVF-ET, and to assess its possible relationship to the artificial reproductive technology.


METHODS
Case report.


METHODS
Infertility and IVF Unit, in a tertiary academic medical center.


METHODS
A 31-year-old healthy patient with a 9-year history of secondary, unexplained infertility.


METHODS
Standard IVF-ET treatment cycle, using GnRH-a (short protocol) and hMG for controlled ovarian hyperstimulation.


RESULTS
Poland anomaly (asymmetric thorax with absence of the right pectoralis major muscle, low set rudimentary right nipple, and very mild hypoplasia of the right upper limb) is described for the first time in an infant who is one of a trizygotic triplet after IVF treatment.


CONCLUSIONS
In view of the currently held hypothesis concerning the pathogenesis of Poland anomaly, the possibility of a teratogen or an event related to the reproductive procedure as the cause of this anomaly seems unlikely.
Beilinson Medical Center, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Israel.
O M
OM
Avrech
P
P
Merlob
A
A
Neri
B
B
Kaplan
J
J
Ovadia
B
B
Fisch
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007231:Infant, Newborn; D008596:Menotropins / Q000627:therapeutic use; D011045:Poland Syndrome / Q000175:diagnosis; D014310:Triplets
D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins