Delayed damage of striatal interneurons after cerebral ischemia in the gerbil.
Immunohistochemical changes of striatal interneurons in the gerbil were investigated 1 h-7 days after 10 min cerebral ischemia. Marked reduction of parvalbumin-immunoreactive interneurons was seen in the striatum from 24 h after ischemia. MAP2 (microtubule-associated protein 2) immunoreactivity markedly decreased in striatal neurons 5 h after ischemia but was unaffected in interneurons. Thereafter, a severe loss of MAP2 immunoreactivity in the interneurons was found 48 h and 7 days after ischemia. The results demonstrate that transient cerebral ischemia can cause a loss of parvalbumin and MAP2 immunoreactivity in interneurons in the dorsolateral striatum in a delayed fashion as compared with a rapid loss of striatal neurons.
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
T
T
Araki
H
H
Kato
X H
XH
Liu
Y
Y
Itoyama
K
K
Kogure
K
K
Kato
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology*; D005849:Gerbillinae; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010320:Parvalbumins / Q000032:analysis / Q000378:metabolism; D013997:Time Factors
D008869:Microtubule-Associated Proteins; D010320:Parvalbumins