Brain osmolyte content and blood-brain barrier water permeability surface area product in osmotic edema.
Brain edema was induced in adult rats by intraperitoneal injection of distilled water equivalent to 15% of the animal's body weight. Mean +/- SEM serum osmolality fell from 291 +/- 3 mOsm to 253 +/- 4 mOsm during the next hour while cerebral gray matter water content increased from 79.5 +/- 0.2% to 80.9 +/- 0.2%. Gray matter content of sodium, potassium, taurine, glycine, glutamine, and glutamate were unchanged. However, the blood-brain barrier permeability/surface area product for water decreased by 40%. This alteration in water permeability may represent a response to limit water influx during the first hour of hypoosmotic brain edema.
Olson
J E
JE
Department of Emergency Medicine, Wright State Unversity School of Medicine, Dayton, OH.
Evers
J A
JA
Banks
M
M
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001929:Brain Edema / Q000503:physiopathology*; D018846:Excitatory Amino Acids / Q000502:physiology; D010296:Parietal Lobe / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013046:Specific Gravity; D014882:Water-Electrolyte Balance / Q000502:physiology*
D018846:Excitatory Amino Acids