Inhibition of interleukin-1-stimulated collagen degradation in cartilage explants.
Mitchell
P G
PG
Department of Immunology and Infectious Diseases, Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
Lopresti-Morrow
L
L
Yocum
S A
SA
Sweeney
F J
FJ
Reiter
L A
LA
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D003094:Collagen / Q000378:metabolism*; D017364:Collagenases / Q000378:metabolism*; D046508:Culture Techniques; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007700:Kinetics; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D009300:Nasal Septum / Q000187:drug effects / Q000201:enzymology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000577:Amides; D007375:Interleukin-1; D011994:Recombinant Proteins; C065557:N-(2-isobutyl-3-(N'-hydroxycarbonylamido)propanoyl)-O-methyltyrosinemethylamide; D014443:Tyrosine; D003094:Collagen; D017364:Collagenases; D008666:Metalloendopeptidases