[Variation of plasma platelet activating factor during development and reversal of hypoxic pulmonary hypertension in conscious sheep].
A model of hypoxic pulmonary hypertension was made in conscious sheep, and plasma platelet activating factor (PAF) were measured by radioimmunoassay method during the beginning, progression and reversal of hypoxic pulmonary hypertension. The main results were as follows: (1) Under hypoxic condition for 4 days, the conscious sheep develops hypoxemia and marked hypoxic pulmonary vasoconstriction (HPV). These response were reversible. (2) At the beginning of hypoxia, plasma PAF increased, but did not continually increase with hypoxic prolongation and development of HPV. (3) Upon cessation of hypoxia with reversal of pulmonary hypertension, plasma PAF did not show any parallel decrease. These results indicate that plasma PAF is in no way involves in the development of HPV in conscious sheep.
Laboratory of Cardiovascular Physiology, Hunan Medical University, Changsha.
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D000818:Animals; D005260:Female; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology; D000860:Hypoxia / Q000150:complications*; D010972:Platelet Activating Factor / Q000378:metabolism*; D011863:Radioimmunoassay; D012756:Sheep; D014661:Vasoconstriction
D010972:Platelet Activating Factor