[Decomposition of chloramphenicol in eyedrops--irritation in the eyes].
Chloramphenicol single dose eyedrops 0.5% (Nycomed Pharma) have been found to be very sensitive to exposure to light. We could detect approximately 15% decomposition after six hours of exposure to diffuse daylight. One of the decomposition products is the extremely irritant dichloroacetic acid. This may explain why some patients complain of a burning sensation in the eyes. In one of the samples of light yellow eyedrop received together with the complaints our analysis revealed 17% of the end-cleavage product p-nitrobenzaldehyde. The Norwegian Medicines Control Authority will suggest to the producers of these preparations that they market the product in special light-proof containers.
Winsnes
R
R
Statens legemiddelkontroll, Oslo.
Borka
L
L
Lønmo
A
A
D002701:Chloramphenicol / Q000009:adverse effects* / Q000737:chemistry / Q000528:radiation effects; D004355:Drug Stability; D005126:Eye Burns / Q000139:chemically induced*; D006801:Humans; D008027:Light / Q000009:adverse effects; D009883:Ophthalmic Solutions / Q000009:adverse effects* / Q000737:chemistry / Q000528:radiation effects
D009883:Ophthalmic Solutions; D002701:Chloramphenicol
Spaltning av kloramfenikol i øyedråper--svie i øynene.