[The dependence of the nitrosation activity of the gastric juice in humans on their age and the type of pathological status of the gastric mucosa].
The study involved two groups of patients aged 6-14 and 40-60 years, and identification of different conditions of gastric mucosa. The study has established a correlation between the nitrosation activity and acidity of gastric juice and the pathological condition of the gastric mucosa. Enhanced nitrosation activity was observed in samples with a pH under 4.0. That activity was at its lowest in cases of normal gastric mucosa, and at its peak--in high-acidity superficial and erosive gastritis. In cases of superficial gastritis with similar levels of acidity, the nitrosation activity of gastric juice for different amines in children was 2-4 times that in adults. The difference in nitrosation levels for different amines tended to diminish with the decrease in the basicity of the amine in question. A linear correlation was observed between the free-radical activity of gastric juice samples and nitrosation activity (correlation coefficient, k = 0.72).
V B
VB
Ermilov
V A
VA
Aleksandrova
L N
LN
Baranova
T N
TN
Ponomareva
A V
AV
Baranovskiĭ
O O
OO
Mos'pan
V G
VG
Chernomordikov
A Ia
AIa
Likhachev
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism*; D002648:Child; D004123:Dimethylamines / Q000493:pharmacokinetics; D005609:Free Radicals; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D015538:Nitrosation; D012977:Sodium Nitrite / Q000493:pharmacokinetics; D013272:Stomach Diseases / Q000378:metabolism*
D004123:Dimethylamines; D005609:Free Radicals; C034516:dimethylamine; D012977:Sodium Nitrite
Zavisimost' nitroziruiushcheĭ aktivnosti zheludochnogo soka liudeĭ ot vozrasta i tipa patologicheskogo sostoianiia slizistoĭ obolochki zheludka.