Combined systemic beta-interferon and thymostimulin administration for metastatic brain tumors. A brief report.
Interferon-beta (IFN-B) plus thymostimulin (Th) were administered for eight weeks, intravenously and by intramuscular route to eight patients with metastatic brain tumors. No patient had a complete response. One had a stable disease and seven a progressive disease during that time. The mechanisms of the action of IFN-B and Th, and the possible therapeutic value are discussed.
Department of Neurosurgery, Faculty of Medicine, University of Messina, Italy.
F M
FM
Salpietro
S
S
Cipri
C
C
Alafaci
M
M
Tripodi
A
A
Alonci
G
G
Buda
F
F
Tomasello
D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D016899:Interferon-beta / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000503:physiopathology; D009460:Neurologic Examination; D013949:Thymus Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D013949:Thymus Extracts; C031407:thymostimulin; D016899:Interferon-beta