Piperonyl butoxide induces hepatocellular carcinoma in male CD-1 mice.
Male CD-1 mice in groups of 52, 53 or 100 were administered piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltol uene) in the diet at levels of 0 (control), 0.6 and 1.2% for 12 months. Hepatocellular carcinoma was induced in treated groups in a dose-dependent manner but not in the control group. The incidences of hepatocellular carcinoma were 11.3 and 52.0% in mice given 0.6 and 1.2% piperonyl butoxide, indicating that piperonyl butoxide can cause hepatocellular carcinoma in mice as it is known to do in rats.
Takahashi
O
O
Oishi
S
S
Fujitani
T
T
Tanaka
T
T
Yoneyama
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010882:Piperonyl Butoxide / Q000633:toxicity*; D013045:Species Specificity
D010882:Piperonyl Butoxide