[Transcription of HSP 70 gene induced by pressure overload in left ventricule of rats].
The changes of heat shock protein 70 (HSP70) messenger RNA was examined in rats after abdominal aortic partial ligation. Four hours after ligation, the systemic arterial pressure was increased and thereafter maintained at a high level. The ratio of left ventricule weight to body weight began to increase at the third day and increased by 59%, comparing with that of the sham-operated rats at 4 w. Accumulation of HSP 70 mRNA was observed at 4 h and maintained at high level at 1 d, 2 d, 1 w and then gradually disappeared there after. The above experimental results suggest that transcription of HSP 70 gene was induced at an early stage of cardiac hypertrophy caused by pressure overload.
Huang
S N
SN
Cardiovascular Basic Research Institute, Beijing Medical University.
Yang
H
H
Zhang
C H
CH
Wen
J K
JK
Tang
C S
CS
Tang
J
J
Zhou
A R
AR
D000818:Animals; D015870:Gene Expression; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000235:genetics*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic
D018840:HSP70 Heat-Shock Proteins; D012333:RNA, Messenger