[Changes in the hepatocytes of adult male rats subjected to the action of 3,4-benzopyrene at different periods of ontogeny].
The effects of benzpyrene (BP) were studied in 32 male Wistar rats. Treatment of intact mature animals with benzpyrene causes transformations of hepatocytes. Antenatal treatment with BP initiates a complex of compensatory-adaptational reactions in the liver of progeny and the effect retains at the postnatal period. The combined ante- and postnatal administration of the toxic drug makes the liver prepared to liquidate the effect of the pathogenic action with the help of a complex of compensatory mechanisms with qualitative changes in cell metabolism.
Borodin
Iu I
IuI
Michurina
S V
SV
Vakulin
G M
GM
Kolesnikov
S I
SI
Semeniuk
A V
AV
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001564:Benzo(a)pyrene
Izmeneniia gepatotsitov u vzroslykh krys-samtsov, podvergnutykh deĭstviiu 3,4-benzpirena v razlichnye periody ontogeneza.