[Antineutrophil cytoplasmic antibodies as marker and follow-up parameter of vasculitis and glomerulonephritis].
Antineutrophil cytoplasmatic antibodies (ANCA) represent a heterogeneous group of autoantibodies targeting cytoplasmatic proteins in neutrophils and monocytes. They can be subdivided into c-ANCA which react with proteinase 3 (PR3) and p-ANCA which recognize myeloperoxidase (MPO). PR3 and MPO are found in the azurophilic granules of neutrophils. Activated neutrophils express these proteins on the cell surface; therefore, they can interact with ANCA. This interaction induces neutrophil degranulation with release of lytic enzymes and free oxygen-radicals. The vasculitic process is thus initiated. The c-ANCA can be detected mainly in Wegener's granulomatosis, and the titers can be used to monitor disease activity. The p-ANCA are mainly found in pauci-immune, rapidly progressive glomerulonephritides (RPGN). Recently, a host of additional inflammatory diseases have been associated with ANCA, for example ulcerative colitis and Crohn's disease. The pathogenic role of ANCA in these inflammatory bowel diseases is largely unknown.
Klinik B für Innere Medizin, Kantonsspital St. Gallen.
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Wüthrich
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000302:isolation & purification*; D015415:Biomarkers; D003093:Colitis, Ulcerative / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification*; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G
Antineutrophile zytoplasmatische Antikörper als Marker und Verlaufsparameter von Vaskulitiden und Glomerulonephritiden.