[Cytogenetic studies on a human cecum adenocarcinoma cell line (HCe-8693)].
Human undifferentiated cecum adenocarcinoma cell line (HCe-8693) was established by Zhejiang Cancer Hospital in 1986. This paper reports the results of cytogenetic studies on the 23rd (early) and 125th (late) passages of this cell line. The numerical distribution range of chromosomes was rather narrow, showing a near diploid karyotype, and no significant difference was observed between early and late passages. The modal number of chromosomes was 49. G-banding karyotypic analysis revealed that the karyotype of this cell line was close to that of normal diploid cells, with few, easily identified abnormal chromosomes. The most significant changes were a distal deletion of the short arm of chromosome No. 1 and a trisomy of chromosome No. 13. The morphological characteristics and possible correlation with pathogenesis of colorectal cancer were briefly discussed.
Cancer Institute, CAMS and PUMC, Beijing.
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Li
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Qian
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Huang
D000230:Adenocarcinoma / Q000235:genetics*; D002430:Cecal Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D007621:Karyotyping; D014314:Trisomy; D014407:Tumor Cells, Cultured