Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31.
The heterodimer alpha v beta 6 acts as a fibronectin receptor for human carcinoma cells. We report here the regional localization of the beta 6 gene to 2q24-q31 by fluorescence in situ hybridization coupled with GTG-banding. This gene is located close to the region to which genes coding for the alpha subunits of the integrins VLA-4 and vitronectin receptor (ITGA4 and ITGAV, respectively) have been previously mapped (2q31-q32). These data suggest a proximal position of the integrin beta 6 locus (ITGB6) on this integrin gene cluster. Furthermore, double-labeling in situ hybridization experiments performed with alpha 4 and alpha v probes indicated a telomeric position of ITGAV with respect to ITGA4.
Departamento de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
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E
Fernández-Ruiz
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F
Sánchez-Madrid
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003094:Collagen / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D039641:Integrin beta Chains; D016023:Integrins / Q000235:genetics*; D008938:Mitosis; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D017469:Receptors, Fibronectin / Q000235:genetics
D005819:Genetic Markers; D039641:Integrin beta Chains; D016023:Integrins; D017469:Receptors, Fibronectin; C072170:integrin beta6; D003094:Collagen