The effect of EGb 761 on retinal lipid peroxidation and glutathione peroxidase level in experimental lens induced uveitis.
An acute lens-induced necrotizing intraocular inflammation was produced in pigmented guinea pigs. Treatment of these animals by 100 mg/kg/day EGb 761 a free oxygen radical scavenger for 10 days, reduced retinal lipid peroxidation (p > 0.05) and increased the retinal glutathione peroxidase level (p > 0.05). Although not significantly, these findings suggest that EGb 761 could be combined with other antiinflammatory drugs and may be beneficial in the treatment of uveitis.
Department of Biochemistry, Gazi University, Medical Faculty, Ankara, Turkey.
A
A
Bilgihan
A
A
Aricioğlu
K
K
Bilgihan
M
M
Onol
B
B
Hasanreisoğlu
N
N
Türközkan
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D020441:Ginkgo biloba; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006168:Guinea Pigs; D007908:Lens, Crystalline; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D014605:Uveitis / Q000188:drug therapy / Q000378:metabolism*; D000096983:Ginkgo Extract
D005979:Glutathione Peroxidase; D008315:Malondialdehyde; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract