[Modifying effect of incorporated 137Cs on the mechanism of adrenergic control of myocardial contraction].
Incorporated 137Cs (absorbed dose of 0.26 Gy) causes decrease of myocardial's contractile function and inotropic response to beta-adrenagonists effect, isoproterenol-stimulated adenylate cyclase activity and beta-adrenoreceptors affinity. Adrenergic effects, mediated by alpha-adrenergic structures on heart contractile function, on the contrary, become stronger, that is due to the increase of the receptors' density on sarcolemma surface.
Lobanok
L M
LM
Bulanova
K Ia
KIa
Gerasimovich
N V
NV
Sineleva
M V
MV
Miliutin
A A
AA
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002588:Cesium Radioisotopes; D004789:Enzyme Activation / Q000528:radiation effects; D009200:Myocardial Contraction / Q000502:physiology / Q000528:radiation effects*; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology / Q000528:radiation effects*; D011943:Receptors, Adrenergic, beta / Q000502:physiology / Q000528:radiation effects*; D013997:Time Factors
D002588:Cesium Radioisotopes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000262:Adenylyl Cyclases
Modifitsiruiushchee vliianie inkorporirovannogo 137Cs na mekhanizmy adrenergicheskogo kontrolia sokratitel'noĭ funktsii miokarda.