Effects of glucose-to-lipid ratio and type of lipid on substrate oxidation rate in patients.
This study is an investigation into the effects of different carbohydrate-to-lipid ratios on CO2 production in postoperative patients and the determination of the substrate oxidation rates induced by long-chain triglycerides (LCT) or a mixture of long- and medium-chain triglycerides (MCT/LCT) at various carbohydrate-to-lipid ratios. Two groups of eight patients randomly received either LCT or MCT/LCT emulsions. Total caloric intake was set at the measured energy expenditure provided at three different glucose-to-lipid ratios (70:30, 50:50, 30:70). We used long-term indirect calorimetry with a mass spectrometer system and measurement of natural enrichment in 13C of expired CO2 and plasma glucose. The carbon dioxide production and minute ventilation were not different among the different glucose-to-lipid ratios, whatever the type of lipid. Increasing the lipid supply up to 70% of nonprotein caloric intake led to an only minor increase in lipid oxidation rate and thus to a net fat deposit. We conclude that large amounts of lipid (LCT or MCT/LCT) were not of interest in such patients.
Intensive Care Unit, Hôpital Edouard Herriot, Lyon, France.
B
B
Delafosse
J P
JP
Viale
S
S
Tissot
S
S
Normand
C
C
Pachiaudi
J
J
Goudable
Y
Y
Bouffard
G
G
Annat
O
O
Bertrand
D000368:Aged; D001769:Blood / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005947:Glucose / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000008:administration & dosage* / Q000145:classification / Q000627:therapeutic use; D008875:Middle Aged; D018529:Nutritional Support; D010084:Oxidation-Reduction / Q000187:drug effects; D010361:Patients; D011182:Postoperative Care; D011659:Pulmonary Gas Exchange
D004655:Emulsions; D008055:Lipids; D005947:Glucose