Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon.
An abundant matrix protein was purified under native conditions from adult bovine tendon and identified as cartilage oligomeric matrix protein (COMP) by immunochemical crossreaction, amino acid sequence identity of tryptic peptides derived from both N- and C-terminal regions, and structure revealed by electron microscopy. Immunohistochemistry showed age-dependent differences in distribution of COMP in tendon.
Cartilage and Bone Research Center, Hosptial for Joint Diseases Orthopaedic Institute, New York, NY 10003.
P
P
DiCesare
N
N
Hauser
D
D
Lehman
S
S
Pasumarti
M
M
Paulsson
D000375:Aging; D000595:Amino Acid Sequence; D000818:Animals; D002358:Cartilage, Articular / Q000737:chemistry; D002417:Cattle; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D007124:Immunoenzyme Techniques; D064235:Matrilin Proteins; D008565:Membrane Proteins / Q000032:analysis* / Q000737:chemistry / Q000648:ultrastructure; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry; D017385:Sequence Homology; D013710:Tendons / Q000737:chemistry*; D014357:Trypsin
D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D008565:Membrane Proteins; D010446:Peptide Fragments; D014357:Trypsin