[Cortisone-induced delusional depression in systemic lupus erythematosus].
A case of systemic lupus erythematodes (SLE) with development of a delusional depression is presented. Psychiatric symptoms in patients with SLE and in patients treated with glucocorticoids are discussed. The main psychiatric side effects of a therapy with steroids are a dose-dependent, reversible dementia like syndrome and a probably not dose-dependent provocation of psychosis. Furthermore the role of the dysregulation of the limbic-hypothalamic-pituitary-adrenocortical axis in major depression is stressed and consequences for psychopharmacological treatment are emphasized.
Psychiatrische Universitätsklinik Basel.
M
M
Hatzinger
E
E
Seifritz
U
U
Hemmeter
E
E
Holsboer-Trachsler
D000328:Adult; D003702:Delusions / Q000139:chemically induced* / Q000523:psychology; D003866:Depressive Disorder / Q000139:chemically induced* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000523:psychology; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000523:psychology
D005938:Glucocorticoids
Kortisoninduzierte wahnhafte Depression bei systemischem Lupus erythematodes.