Platelet paroxetine binding in depressed and nondepressed chronic pain patients.
Analysis of 3H-paroxetine binding was used to determine the number of serotonin transporters in platelet membranes of chronic pain patients and controls. The pain patients who also suffered from depression in addition to the pain had significantly more serotonin transporters than the controls.
Multidisciplinary Pain Center, Bispebjerg Hospital, Copenhagen, Denmark.
N H
NH
Jensen
L
L
Lauritzen
M
M
Lunde
J
J
Eriksen
P
P
Plenge
E T
ET
Mellerup
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003866:Depressive Disorder / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood* / Q000523:psychology; D010147:Pain Measurement; D017374:Paroxetine / Q000493:pharmacokinetics*; D011985:Receptors, Serotonin / Q000378:metabolism
D015415:Biomarkers; D011985:Receptors, Serotonin; D017374:Paroxetine