Prevalences of thalassemia/hemoglobinopathies and G-6-PD deficiency in malaria patients.
It seems that thalassemia and/or hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency (G-6-PD) have some protective effects against malaria infection. To verify this, hemoglobin typing and methehoglobin reduction test were performed on 115 malaria patients and compared with controls. It was found that the number of thalassemia/hemoglobinopathies in the malaria group and in the control group were not significantly different and also occurrence of G-6-PD deficiency in the malaria group was not different from that of the controls. Clinical manifestations of malaria in any group are quite similar. It is concluded that there is no protective effect against malaria in thalassemia/hemoglobinopathies or G-6-PD deficiency.
Department of Internal Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.
S
S
Insiripong
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P
Tulayalak
C
C
Amatachaya
D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003906:Developing Countries; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000201:enzymology / Q000453:epidemiology*; D006453:Hemoglobinopathies / Q000201:enzymology / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008288:Malaria / Q000201:enzymology / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D013789:Thalassemia / Q000201:enzymology / Q000453:epidemiology*
D005954:Glucosephosphate Dehydrogenase