Low anti-streptokinase IgG concentrations following streptokinase-streptodornase treatment of leg ulcer patients.
We have evaluated whether neutralising anti-streptokinase IgG antibodies are produced following streptokinase-streptodornase therapy of leg ulcer patients. Serum anti-streptokinase IgG concentrations in 10 leg ulcer patients were determined before, and 1 week, 2 weeks, and 3 weeks following the treatment. We observed only a negligible increase in neutralizing anti-streptokinase IgG concentrations during the observation period, which was probably of no therapeutical significance.
Department of Dermatology, Bispebjerg University Hospital of Copenhagen, Denmark.
S
S
Munkvad
L
L
Breuning
J
J
Tvedskov
D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007871:Leg Ulcer / Q000188:drug therapy* / Q000276:immunology; D013299:Streptodornase and Streptokinase / Q000627:therapeutic use*; D013300:Streptokinase / Q000276:immunology*
D007074:Immunoglobulin G; D013299:Streptodornase and Streptokinase; D013300:Streptokinase