[Effect of a leukotriene antagonist, ONO-1078, on electric stimulation of vagus (ESV)-induced bronchoconstriction and microvascular leakage in guinea pigs].
In atropine-pretreated guinea pigs, electric stimulation of vagus (ESV, 10 Hz, 5 ms, 2 V or 10 V, for 90 s) increased intrapulmonary pressure (IPP), and Evans blue extravasation in trachea, main bronchi, peripheral and distal intrapulmonary airways in a voltage-dependent manner. ONO-1078, a noval leukotriene antagonist, (0.03 and 0.1 mg.kg-1, iv) showed no remarkable inhibiting effect on ESV-induced increase of IPP. However, the agent significantly inhibited ESV-induced increase of Evans blue extravasation in the airways, especially in lower potency of stimulation (2 V). The results suggest that leukotrienes may be involved in airway microvascular leakage in response to neurogenic inflammation.
Wei
E Q
EQ
Department of Pharmacology, Zhejiang Medical University, Hangzhou.
Wang
Y C
YC
Chen
L P
LP
Tang
F D
FD
Bian
R L
RL
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D002867:Chromones / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D017997:Leukotriene C4 / Q000037:antagonists & inhibitors*; D008297:Male; D014630:Vagus Nerve
D002867:Chromones; D017997:Leukotriene C4; C047681:pranlukast