[Evaluation of parasternal (Ps) and supraclavicular (Sc) node dissection combined with targeting chemotherapy (activated carbon particle adsorbing aclarubicin) in breast cancer with Ps node involvement--usefulness of extended surgery for improvement of prognosis].
We treated breast cancer patients with Ps node involvement using an extended surgery (Ps+Sc, n = 17, group A) combined with targeting chemotherapy and compared the survival rate by this method with that by the dissection of the Ps node alone (n = 23, group B) to assess the prognosis of advanced breast cancer by extended surgery. 1) Overall patients: The disease-free survival rate was significantly higher in group A, while the overall survival rate was not significant. 2) Survival rate in relation to the number of metastatic Ps nodes or axillary (Ax) nodes: In patients with Ps = 1 or Ax < or = 3, the difference in the overall and disease-free rates were not significant. In patients with Ps > or = 2 or Ax > or = 4, both overall and disease-free rates were significantly higher in group A. It was therefore suggested that extended surgery should be performed if metastasis is found in 2 or more Ps nodes in the frozen section intraoperatively. The result of this study, although it is not a randomized trial, suggested a possibility that extended surgery may improve the prognosis of advanced breast cancer.
Department of Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan.
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T
Asaga
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Masuzuma
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A
Yoshida
D015250:Aclarubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D002244:Carbon; D002968:Clavicle; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D015410:Mastectomy, Extended Radical; D008875:Middle Aged; D011379:Prognosis; D013249:Sternum
D002244:Carbon; D015250:Aclarubicin