Successful bone marrow transplant for Fanconi anaemia in transformation.
We present a patient who was diagnosed as suffering from Fanconi anaemia at the age of 36 years. At the time of diagnosis his bone marrow showed features of pre-leukaemic transformation. He received an allogeneic bone marrow transplant (BMT) from his HLA-identical sibling. The post-transplant course was unremarkable with evidence of trilineage engraftment at day +32 and no acute or chronic GVHD. He is well with sustained engraftment and no haematological evidence of Fanconi anaemia 18 months post-transplant.
Philpott
N J
NJ
Department of Haematology, St. George's Hospital Medical School, London.
Marsh
J C
JC
Kumaran
T O
TO
Yardumian
A
A
Lawler
M
M
McCann
S R
SR
Gordon-Smith
E C
EC
D000328:Adult; D016026:Bone Marrow Transplantation; D002678:Chimera / Q000235:genetics; D004276:DNA, Satellite / Q000235:genetics; D005199:Fanconi Anemia / Q000235:genetics / Q000628:therapy*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011289:Preleukemia / Q000235:genetics / Q000628:therapy*; D014184:Transplantation, Homologous
D004276:DNA, Satellite