[Pedigrees of 110 patients with Graves' disease and the determinations of antithyroid antibodies in their first-degree relatives].
We studied 810 pedigree members of 110 patients with Graves' disease. In 700 first-degree relatives, inquiry of medical history, physical examination (eyes, thyroid, heart rate, etc), thyroid function tests (serum T3, T4 and TSH), determinations of thyroglobulin antibodies (TgAb) and thyroid microsomal antibodies (TmAb) were carried out. For male (female) probands, the incidence of Graves' disease in first-degree relatives was investigated and their serum TgAb and TmAb were analyzed. In addition, we also analyzed the positive rates of these two kinds of autoantibodies of male (female) first-degree relatives of familial and nonfamilial Graves' disease. Eighteen persons with positive TgAb and TmAb from 5 pedigrees were followed up, one year after initial determinations. The morbidity of male (female) patients of male (female) probands of Graves' disease, the results of the determinations of TgAb and TmAb of male (female) first-degree relatives, the changes of TgAb and TmAb of the male (female) first-degree relatives of familial and nonfamilial Graves' disease are discussed.
Department of Endocrinology, Affiliated Hospital, Shandong Medical University, Jinan.
D Q
DQ
Wang
J H
JH
Wang
J M
JM
Ren
D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D012737:Sex Factors; D013954:Thyroglobulin / Q000276:immunology*
D001323:Autoantibodies; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin