Dysfunction of the medullary cardiovascular center may cause acute spinal cord swelling.
Acute brain swelling is well known to be acute vasodilatation of cerebral vessels and sometimes results from brain injury. One of the causes of acute brain swelling may be disturbance of central control mechanisms of cerebral vessels. However, the presence of acute spinal cord swelling is little noticed. We present here a possibility that acute spinal cord swelling may be occur following the dysfunction of the cardiovascular center of the medulla. In urethane-anesthetized, paralyzed and artificially ventilated rats, the neurons in the rostral ventrolateral pressor area (VLPA), origin of the sympathetic nerve activities in the brain stem, were chemically stimulated by microinjection of L-glutamate and the spinal cord blood flow (SCBF) was determined using labeled microspheres. The SCBFs of cervical, thoracic, and lumbar cord decreased significantly from 27 +/- 3 (mean +/- S.E.M.) to 20 +/- 2 (p < 0.01), from 22 +/- 1 to 17 +/- 2 (p < 0.05), and from 41 +/- 5 to 26 +/- 3 (p < 0.05) ml.min-1.(100 g)-1, respectively (n = 12). The spinal cord vascular resistances (SCVRs) of cervical, thoracic, and lumbar cord increased significantly from 3.7 +/- 0.4 to 5.0 +/- 0.6 (p < 0.05), from 4.2 +/- 0.2 to 5.9 +/- 0.7 (p < 0.05), and from 2.5 +/- 0.2 to 3.8 +/- 0.4 (p < 0.05) mmHg per [ml.min-1.(100 g)-1], respectively (n = 12). These results suggest that the neurons within the VLPA may play a role in the control of spinal cord circulation. There is a possibility that the dysfunction of the VLPA may cause acute spinal cord swelling.
Maeda
M
M
Department of Systems Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nakai
M
M
Krieger
A J
AJ
Sapru
H N
HN
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001931:Brain Mapping; D002199:Capillary Permeability / Q000502:physiology*; D002319:Cardiovascular System / Q000294:innervation*; D004487:Edema / Q000503:physiopathology*; D018698:Glutamic Acid / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D013116:Spinal Cord / Q000098:blood supply*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D018698:Glutamic Acid