Nutrient-specific effects of modified sham feeding on pancreatic polypeptide release.
OBJECTIVE
To study the effect of meal composition on pancreatic polypeptide release during modified sham feeding.


METHODS
In random order and on separate occasions, isocaloric, isothermic, isoosmotic, homogenized meals (1050 kJ; 250 kcal) either rich in fat (walnuts; 64 g fat, 7 g protein, 15 g starch per 100 g), protein (codfish, 1 g fat, 23 g protein per 100 g) or carbohydrates (bananas; 22 g starch, 1 g protein per 100 g) were sham-fed for 30 min by tasting and spitting out the meal. The plasma pancreatic polypeptide response was monitored by radioimmunoassay at 10 min intervals from 20 min before to 120 min after modified sham feeding.


METHODS
Department of Gastroenterology and Hepatology of a University Hospital.


METHODS
Seven healthy volunteers: 3 male, 4 female; age 45 (range 30-77) years.


RESULTS
Integrated plasma pancreatic polypeptide responses to modified sham feeding of codfish (1088 +/- 395 pM*120 min; P < 0.05) and walnuts (1200 +/- 542 pM*120 min) were distinctly higher (P < 0.05) than to modified sham feeding of bananas (-390 +/- 291 pM*120 min).


CONCLUSIONS
These results demonstrate that the pancreatic polypeptide response to modified sham feeding is dependent on the composition of the meal.
Witteman
B J
BJ
Department of Gastroenterology, University Hospital of Nigmegen, The Netherlands.
Edwards-Teunissen
K
K
Hopman
W P
WP
Jebbink
M C
MC
Masclee
A A
AA
Lamers
C B
CB
Jansen
J B
JB
D000328:Adult; D000368:Aged; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000097:blood / Q000187:drug effects* / Q000378:metabolism*; D011863:Radioimmunoassay; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D010191:Pancreatic Polypeptide