Borna disease in naturally infected cattle.
Based on the immunohistochemical demonstration of viral antigen and on the histological brain lesions, Borna disease was diagnosed in a cow and a bull which had suffered from a severe, subacute progressive disorder of the central nervous system. Virus-specific antigen was characteristically localized in neurons, predominantly in the perikaryon and dendrites. In a serum sample available from one of the animals a Borna disease virus antibody titre of 1 in 80 was demonstrated. This is the first report of the natural disease in cattle.
Institut fuer Veterinaerpathologie, Universitaet Zurich, Switzerland.
P
P
Caplazi
A
A
Waldvogel
L
L
Stitz
U
U
Braun
F
F
Ehrensperger
D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001890:Borna Disease / Q000175:diagnosis*; D001891:Borna disease virus / Q000276:immunology; D001921:Brain / Q000473:pathology / Q000821:virology; D001927:Brain Diseases / Q000175:diagnosis / Q000662:veterinary* / Q000821:virology; D002417:Cattle; D005260:Female; D007124:Immunoenzyme Techniques / Q000662:veterinary; D008297:Male
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral