[Effects of stimulation of ventromedian area of nucleus hypoglossus on respiratory rhythm in rabbits].
The effects of electrical and chemical stimulation of ventromedian area of nucleus hypoglossus (VMNH) on the electrical activities of diaphragm and genioglossus were studied in 25 urethane-anesthetized, vagotomized rabbits. The experimental results were as follows: (1) A 6 s train of electrical stimulation caused a complete cessation of diaphragmatic activities and an excitation of genioglossal activities. (2) A 0.1 s train of stimulation of the nucleus during the middle or late inspiratory phase could elicit an inspiratory off-switch effect. (3) Microinjection of L-glutamate into VMNH also produced an inhibition of diaphragmatic activities. The above observations suggest that VMNH activity exerts a regulatory effect on respiratory rhythm, and this effect may be involved in the central mechanism of swallowing reflex.
Department of Physiology, Shandong Medical University, Jinan.
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D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D003964:Diaphragm / Q000502:physiology*; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D007002:Hypoglossal Nerve / Q000502:physiology*; D008297:Male; D011817:Rabbits; D012119:Respiration / Q000502:physiology*; D014628:Vagotomy