[A case of complete response of breast cancer with pulmonary metastases to combination therapy of 5'-DFUR and MPA].
This paper presents a case with lung metastases from breast cancer. Complete response was obtained by combined chemoendocrine therapy with 5'-DFUR and MPA. The patient was a 62-year-old female. She underwent a standard radical mastectomy in April, 1988. The primary legion was ER (-) and PgR (-). Postoperative treatments using CMF and CAF were eventually discontinued owing to profound damage to the bone marrow. An adjuvant chemotherapy with UFT has been employed since. Two years and 7 months later, hemosputum and coughing appeared, and metastases to the lung were revealed. Combined chemoendocrine therapy with 5'-DFUR and MPA was undertaken. A significant decrease in tumor size was observed 3 months after the chemoendocrine therapy was begun, and complete response was obtained at the 8th month. The state has been maintained for one year and 9 months. The use of combined chemoendocrine therapy with 5'-DFUR and MPA in patients for whom intensive chemotherapy is not possible due to damage to bone marrow function is considered effective for its antitumor effects or maintaining patients' quality of life.
Dept. of Surgery, Iida Municipal Hospital.
O
O
Senga
M
M
Miyakawa
H
H
Hikita
N
N
Horigome
S
S
Kouzu
K
K
Kuwae
T
T
Hanaoka
K
K
Yoshida
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004359:Drug Therapy, Combination; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D015409:Mastectomy, Radical; D008525:Medroxyprogesterone / Q000008:administration & dosage*; D008875:Middle Aged; D012074:Remission Induction
D005467:Floxuridine; D008525:Medroxyprogesterone; C025034:doxifluridine