Vitamin K status and parenteral nutrition; the effect of Intralipid on plasma vitamin K1 levels.
Parenteral nutrition may affect the patient's vitamin K status. This imposes a risk when using drugs that interfere with the vitamin K-dependent clotting factor synthesis, such as N-methyl-thiotetrazole-containing cephalosporins. Intravenous lipid emulsions based on plant oils may contain phylloquinone (vitamin K1). We estimated the vitamin K1 content of the intravenous lipid emulsion product Intralipid (20%), an emulsion based on soybean oil, and estimated the vitamin K1 status of recipient patients. The emulsion was found to contain 0.6-0.7 micrograms/ml of the vitamin. Patients supplied with the product per continuous intravenous infusion, showed a steady increase of their plasma vitamin K1 levels, 3-30-fold over 4 days of infusion. In conclusion, the study shows that fat emulsions prepared from plant oils may contain vitamin K1 in sufficient amounts to meet the daily requirement.
Department of Pharmacology, University Hospital, University of Limburg, Medical Faculty, Maastricht, The Netherlands.
M J
MJ
Drittij-Reijnders
J P
JP
Sels
M
M
Rouflart
H H
HH
Thijssen
D002985:Clinical Protocols; D004347:Drug Interactions; D016903:Drug Monitoring; D005217:Fat Emulsions, Intravenous / Q000032:analysis / Q000494:pharmacology* / Q000600:supply & distribution; D006801:Humans; D009751:Nutritional Requirements; D010288:Parenteral Nutrition; D010938:Plant Oils; D014812:Vitamin K / Q000032:analysis* / Q000493:pharmacokinetics
D005217:Fat Emulsions, Intravenous; D010938:Plant Oils; D014812:Vitamin K