Long-term preservation and induction of drug metabolizing enzymes in co-cultured rat hepatocytes.
Akrawi
M
M
Department of Biochemistry and Molecular Biology, University College London, U.K.
Rogiers
V
V
Vercruysse
A
A
Phillips
I R
IR
Shephard
E A
EA
D000818:Animals; D002478:Cells, Cultured; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D004790:Enzyme Induction; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014635:Valproic Acid / Q000494:pharmacology
D004364:Pharmaceutical Preparations; D012333:RNA, Messenger; D014635:Valproic Acid; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital