Chromosome abnormalities in breast fibroadenomas.
Cytogenetic analysis of 25 breast fibroadenomas (FA) showed clonal chromosome alterations in three cases. Insertion (12;?) (q15;?) and deletion (2) (q14q31 or q32) were detected as a sole change in cases 1 and 3, respectively. Case 2 displayed the karyotype 45,XX,t(1;8;16)(q25;q23;q22-23), add (7)(p14), rea(15), -17. The present findings are discussed together with the reports on FA in the literature.
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Y Y
YY
Ozisik
A M
AM
Meloni
C F
CF
Stephenson
A
A
Peier
G E
GE
Moore
A A
AA
Sandberg
D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D018226:Fibroadenoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D000091402:Prohibitins