Clinical response of abnormal endometrial growth to hormonal treatment.
The diverse types of abnormal endometrial tissue growth have received different forms of treatment, with a particular emphasis on the use of hormonal agents. Hyperplastic endometria have benefited from progesterone or progestin therapies, with good results. Endometrial cancer is a disease with a major indication for surgical treatment. However, advanced clinical stages have been shown to improve as a result of different medical treatments. This presentation reviews the literature on this subject, includes some considerations on the role of some antiestrogens as endometrial tumor promoters in certain patients undergoing adjuvant therapy, and discusses the possibilities of Gn-RH analogs, one of the recent proposals in the treatment of adenocarcinomas and endometrial hyperplasia, including morphological observations of an investigation currently in progress in our department.
Department of Obstetrics and Gynecology, Universidad Complutense, Hospital Universitario San Carlos, Madrid, Spain.
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López de la Osa González
D000230:Adenocarcinoma / Q000188:drug therapy*; D004714:Endometrial Hyperplasia / Q000188:drug therapy*; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D011372:Progestins / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use
D006728:Hormones; D011372:Progestins; D013629:Tamoxifen; D007987:Gonadotropin-Releasing Hormone