Retardation of cell aging by lipid peroxidation. II.
Fe2+/vitamin C system was used to stimulate lipid peroxidation in human diploid fibroblasts derived from embryonic lung tissue to study the relationship between lipid peroxidation and cell senescence. The results showed that certain low levels of lipid peroxidation could evidently improve cellular morphology and prolong 2-8 days of cell survival time. All cellular SOD activities of control and treatment groups decreased with cell subculture. However, SOD activities of treatment groups were not higher than that of the control, which indicated that under certain circumstances SOD would not play an important role in retardation of cell aging.
Department of Biology, Lanzhou University, China.
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Zheng
D002460:Cell Line; D016922:Cellular Senescence; D005333:Fetus; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D015227:Lipid Peroxidation; D008168:Lung / Q000166:cytology; D013482:Superoxide Dismutase / Q000378:metabolism
D013482:Superoxide Dismutase