Incidence of bacteremia associated with chorionic villus sampling.
OBJECTIVE
To assess the frequency of transient bacteremia among women undergoing transabdominal and transcervical chorionic villus sampling (CVS).


METHODS
One hundred fourteen women undergoing CVS consented to participate in a university review board-approved study protocol. Exclusion criteria included known cardiac valve anomaly or replacement (or other prosthetic) and antibiotic use within the preceding 21 days. Blood cultures (aerobic and anaerobic) were drawn by a single operator on all patients, before CVS and within 15 minutes after completing CVS. Either the catheter tip or needle tip aspirate from each procedure was also sent for culture.


RESULTS
Post-procedure bacteremia was detected in two (1.8%) of the patients undergoing CVS. These two patients both had their procedures performed transcervically, resulting in a 4.1% (two of 49) bacteremia rate after transcervical CVS, compared to none (zero of 65) in the transabdominal group (P = .36). The incidence of positive cultures from sampling instruments was also higher in the transcervical group (16.3 versus 0%; P = .003), but did not result in comparable rates of bacteremia among patients with positive instrument cultures.


CONCLUSIONS
In this study, CVS was associated with a low rate of bacteremia, regardless of the procedure route. Recommendations for antibiotic prophylaxis in women with abnormal cardiac valves should parallel those for spontaneous vaginal delivery and other comparable genitourinary procedures.
Division of Medical Genetics, Thomas Jefferson University, Philadelphia, Pennsylvania.
N S
NS
Silverman
M W
MW
Sullivan
D L
DL
Jungkind
V
V
Weinblatt
K
K
Beavis
R J
RJ
Wapner
D016470:Bacteremia / Q000209:etiology*; D015193:Chorionic Villi Sampling / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D011247:Pregnancy