Pharmacokinetics and pharmacodynamics of tizanidine.
The relationship among tizanidine dose, plasma concentration, and antispastic action is linear in nature. Response to a given dose of this agent varies among patients, and determining the appropriate clinical dose requires individual titration.
Department of Medicine, Dundee University, Scotland, United Kingdom.
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Roberts
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Pokorny
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Muir
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D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009125:Muscle Relaxants, Central / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D009128:Muscle Spasticity / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine