[Two cases of asymptomatic primary biliary cirrhosis (PBC) accompanied with CREST syndrome].
Two cases of asymptomatic primary biliary cirrhosis (PBC) combining CREST syndrome. We have had encountered two primary biliary cirrhosis (PBC) patients overlapped with CREST syndrome. Case 1 was a 51-year-old female, who was suffering from Raynaud's phenomenon, esophageal dysmotility and sclerodactyly. Case 2 was a 67-year-old female, who was suffering from Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia. They were free from itching and icterus. The histology of their biopsied liver specimen should stage I-II of Scheuer's classification. Their immunological findings showed anti-centromere antibody, (ACA) at a high titer (1 : 1280 dilution) and anti-mitochondrial antibody (AMA) at a low titer (1 : 40 dilution) positive in both. HLA DR types included DR2 and DRW8 in case 1, and did DR1 and DRW6 in case 2. Both patients are having good prognosis.
Takeda
I
I
Department of Internal Medicine, Ohota Nishinouchi Hospital, Fukushima.
Igarashi
S
S
Oyanagi
H
H
Irisawa
A
A
Mukai
S
S
Shoji
I
I
Sakuma
H
H
Satho
H
H
Sekine
K
K
Kuroda
M
M
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D017675:CREST Syndrome / Q000150:complications*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008875:Middle Aged
D001323:Autoantibodies