Detection of GM-CSF in the sera of children with Langerhans' cell histiocytosis.
GM-CSF induces proliferation and activation of Langerhans' cells in vitro. The density of Langerhans' cells in human tumours is correlated to the in situ density of GM-CSF, and intradermal injection of GM-CSF induces local accumulation of Langerhans' cells. Therefore, we investigated the presence of GM-CSF in the sera of children with Langerhans' cell histiocytosis (LCH). We detected GM-CSF in the sera of all children with disseminated and active LCH, but not in the sera of patients with localized (i.e. bone) LCH. These results suggest that GM-CSF level is related to extent and the activity of LCH.
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Necker-Enfants Malades, Villejuif, France.
J F
JF
Emile
E
E
Tartour
L
L
Brugières
J
J
Donadieu
F
F
Le Deist
I
I
Charnoz
A
A
Fischer
W H
WH
Fridman
N
N
Brousse
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology*; D006801:Humans; D007223:Infant
D016178:Granulocyte-Macrophage Colony-Stimulating Factor