[The use of prednisolone for the attenuation of the nephrotoxic effect of cisplatin].
Rats experiments have indicated that prednisolone significantly decreases the nephrotoxic effect of the antitumor drug cisplatin. A single injection of the agent in a dose of 5 mg/kg body weight was followed by acute renal failure, which led to an increase in serum levels of creatinine and urea, to a rise in kidney weight, changes in renal water and ion content. The injection of prednisolone (5 mg/kg body weight) 3 hours prior to cisplatin administration resulted in a two-fold decrease in the concentration of nitrogen metabolic end products, without any effects on renal tissue. The protective effect of the hormone is not related to the decrease in renal cisplatin accumulation.
V T
VT
Bakhteeva
L A
LA
Karpenko
D000818:Animals; D001769:Blood / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D004347:Drug Interactions; D005260:Female; D007668:Kidney / Q000737:chemistry / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D011239:Prednisolone; D002945:Cisplatin
Ispol'zovanie prednizolona dlia oslableniia nefrotoksicheskogo éffekta tsisplatina.