Effect of morphine and naloxone on LH response and sexual behavior of rams (Ovis aries).
Effects of the opiate agonist, morphine, and antagonist, naloxone, on LH release, courtship behavior and ejaculation frequency of mature, sexually active or sexually inactive rams were investigated. Plasma LH concentrations were monitored from blood samples collected every 15 min for 10 hr (0800 to 1800 hr) from eight rams that were isolated from or in contact with estrous females. Plasma LH concentration was higher (P < .05) in sexually active rams exposed to receptive females compared with hormone concentration of rams isolated from ewes. Intravenous infusion of morphine sulphate (1 mg/kg) into rams 4 and 6 hr after exposure to ewes reduced (P < .05) plasma LH concentration as compared to rams given saline. Morphine did not affect (P > .05) courtship behavior (investigatory sniff, mount attempt, foreleg kick, flehmen, vocalization) but diminished (P < .05) number of ejaculations. In another trial, LH concentrations were higher (P < .05) in seven sexually active rams given naloxone iv or when given to three rams through an intracerebroventricular cannula (icv) as compared to LH response of sexually inactive rams. LH did not differ (P > .05) in seven sexually inactive rams before or after administration of naloxone. Investigatory sniffs by sexually active rams were increased (P < .03) after treatment with the opiate antagonist. Four of the seven sexually active rams had more ejaculations after naloxone compared with the pretreatment period, but mean ejaculation frequency after treatment did not differ (P = .31). Naloxone did not stimulate courtship behavior of sexually inactive males.(ABSTRACT TRUNCATED AT 250 WORDS)
USDA-ARS, Dubois, Idaho 83423.
J A
JA
Fitzgerald
A
A
Perkins
D000818:Animals; D004542:Ejaculation / Q000187:drug effects; D007262:Infusions, Intravenous; D007276:Injections, Intraventricular; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D012725:Sexual Behavior / Q000187:drug effects*; D012756:Sheep / Q000502:physiology*
D009270:Naloxone; D009020:Morphine; D007986:Luteinizing Hormone