Potential-dependent Ca2+ currents in isolated heart cells of hibernators.
Using the perforated patch-clamp technique, it has been shown that the potential-dependent Ca2+ current in cardiac myocytes of hibernators is not completely inhibited during hibernation. The residual Ca2+ current is classed as L-type Ca2+ current which is regulated by agonists and antagonists of Ca2+ channels. The effect of nifedipine, D600, isoproterenol and forskolin has been examined. It was found that isoproterenol affects the affinity of Ca2+ channels for the D600 blocker.
Laboratory of Functional Biochemistry, Russian Academy of Sciences, Pushchino, Moscow Region.
A E
AE
Alekseev
A F
AF
Korystova
D A
DA
Mavlyutova
Y M
YM
Kokoz
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects; D002478:Cells, Cultured; D005576:Colforsin / Q000494:pharmacology; D004553:Electric Conductivity; D004594:Electrophysiology; D005711:Gallopamil / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006605:Hibernation / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D008564:Membrane Potentials; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D009543:Nifedipine / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D012589:Sciuridae
D015220:Calcium Channels; D005576:Colforsin; D005711:Gallopamil; D009543:Nifedipine; D007545:Isoproterenol; D002118:Calcium