Nadolol for lithium tremor in the presence of liver damage.
Lithium-induced tremor classically responds to treatment with propranolol. Since it is metabolized in the liver, propranolol may not be the drug of choice in those patients who have compromised liver function or who are recovering from prior liver diseases. Another nonselective beta-adrenergic blocker, nadolol, has no hepatic biotransformation. We present here the first case report of successful treatment of lithium-induced tremor with nadolol, which was selected because the patient had compromised liver function. The patient's liver function tests remained stable with the therapy.
Unit Medical Director, Georgia Mental Health Institute, Atlanta 30306.
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Langbart
D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D009248:Nadolol / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019965:Neurocognitive Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D014202:Tremor / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy
D009248:Nadolol; D008094:Lithium