Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.
Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA 02115.
V A
VA
Boussiotis
D L
DL
Barber
T
T
Nakarai
G J
GJ
Freeman
J G
JG
Gribben
G M
GM
Bernstein
A D
AD
D'Andrea
J
J
Ritz
L M
LM
Nadler
D002460:Cell Line; D017635:Clonal Anergy / Q000276:immunology*; D002999:Clone Cells; D015809:HLA-DR7 Antigen / Q000276:immunology; D006801:Humans; D007378:Interleukins / Q000276:immunology; D053616:Janus Kinase 3; D008213:Lymphocyte Activation; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D015809:HLA-DR7 Antigen; D007378:Interleukins; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D011505:Protein-Tyrosine Kinases; C507933:JAK3 protein, human; D053616:Janus Kinase 3