Pilomatrix carcinoma. A case report with immunohistochemical findings, flow cytometric comparison with benign pilomatrixoma and review of the literature.
We report a case of pilomatrix carcinoma in a 42 year old woman. The patient presented a rapidly growing 4-cm subcutaneous mass in the right preauricular area. She was free of recurrence 24 months after surgery. Immunoreactivity was studied for cytokeratins, epithelial membrane antigen, S-100 protein, blood group antigens, Leu-M1, beta-2-microglobulin, vimentin, neuron-specific-enolase and cellular binding for peanut agglutinin. Squamous cells were reactive for cytokeratin AE1/3, epithelial membrane antigen, blood group antigens B and H, and peanut agglutinin. Basaloid cells were focally reactive for cytokeratin AE1/3 and epithelial membrane antigen. Flow cytometry revealed a euploid DNA content and a high proliferative rate of the pilomatrix carcinoma and in benign pilomatrixoma studied for comparison. The pathological diagnosis must be based on histomorphological criteria.
Panico
L
L
Institute of Pathology, University of Naples, Italy.
Manivel
J C
JC
Pettinato
G
G
De Rosa
N
N
Ruggiero
A
A
De Rosa
G
G
D000328:Adult; D005260:Female; D005434:Flow Cytometry; D006201:Hair Diseases / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D018296:Pilomatrixoma / Q000473:pathology*; D016196:S Phase; D012878:Skin Neoplasms / Q000473:pathology*