Release profiles of phenytoin from new oral dosage form for the elderly.
Utilization of the solid mass containing phenytoin, sodium caseinate and microcrystalline cellulose (MCC) as a new dosage form for the elderly was studied. The solid mass was prepared by treatment of the powder mixture with high pressure steam at 115 degrees C for 10 min. The stability of phenytoin in the solid mass was confirmed by infrared spectroscopy and high performance liquid chromatography. The extent of swelling of the solid mass containing phenytoin was investigated by water absorption test and gel strength test, and the swelling property was almost independent of the presence of phenytoin. The release profile of phenytoin from the solid mass was determined under various conditions, and was found to be influenced by the extent of swelling and the swollen state. It was observed that the protein adsorption to the phenytoin crystal surface and the addition of digestive enzyme also affected the release profile. In water, the solid mass prepared from a ground mixture of phenytoin and MCC showed remarkable improvement of release profile of phenytoin.
Pharmaceutical Department, Tokyo Women's Medical College, Japan.
A
A
Watanabe
T
T
Hanawa
M
M
Sugihara
K
K
Yamamoto
D000042:Absorption; D000284:Administration, Oral; D000368:Aged; D002364:Caseins / Q000737:chemistry / Q000378:metabolism; D004304:Dosage Forms; D016503:Drug Delivery Systems; D004355:Drug Stability; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage* / Q000737:chemistry
D002364:Caseins; D004304:Dosage Forms; D010672:Phenytoin