The biology and behaviour of intracerebral adrenal transplants in animals and man.
The catecholamine containing chromaffin cells of the adrenal medulla have recently been employed as intracerebral grafts in man and animals with lesions of the nigrostriatal dopaminergic system. This review outlines the basic biology of the chromaffin cell with reference to its efficacy as a source of dopamine in the grafted state. This is followed by an evaluation of the use of these grafts in experimentally lesioned animals and in patients with Parkinson's disease.
MRC Cambridge Brain Repair Centre, University of Cambridge, U.K.
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R
Barker
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S
Dunnett
D000313:Adrenal Medulla / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation; D000818:Animals; D001921:Brain / Q000502:physiology*; D002838:Chromaffin System / Q000166:cytology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D010300:Parkinson Disease / Q000601:surgery
D004298:Dopamine