Lymphotactin: a cytokine that represents a new class of chemokine.
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.
Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304.
G S
GS
Kelner
J
J
Kennedy
K B
KB
Bacon
S
S
Kleyensteuber
D A
DA
Largaespada
N A
NA
Jenkins
N G
NG
Copeland
J F
JF
Bazan
K W
KW
Moore
T J
TJ
Schall
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D054407:Chemokine CCL4; D019744:Chemokines, C; D002634:Chemotaxis, Leukocyte; D016207:Cytokines / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008222:Lymphokines / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D019402:Macrophage Inflammatory Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D015846:Monokines / Q000494:pharmacology; D011994:Recombinant Proteins; D016415:Sequence Alignment; D012795:Sialoglycoproteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D054407:Chemokine CCL4; D019744:Chemokines, C; D016207:Cytokines; D008222:Lymphokines; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; C092390:XCL1 protein, human; C486249:Xcl1 protein, mouse; C018997:lymphotactin; D002118:Calcium