Potential carcinogenicity assessment of alpha-aescin and phenbendasol.
Potential carcinogenic activity of alpha-aescin and phenbendasole made by "Polfa" (Poland) as well as phenbendasole produced by "Hoechst" (Germany) was studied using Salmonella/microsome test, DNA repair test and micronucleus assay. None of tested preparations were mutagenic or genotoxic what suggest that none of them possess potential carcinogenic activity. Besides, it was established that alpha-aescin exhibits strong and phenbendasol weak acute systemic toxicity for mice. Alpha-aescin and phenbendasole produced in Poland have been found to be toxic for bone marrow cells of mice but only when administered at a high dose of 80% LD50.
Department of Occupational Carcinogenesis, Institute of Occupational Medicine, Lódź, Poland.
B
B
Przybojewska
B
B
Barański
E
E
Spiechowicz
E
E
Dziubałtowska
W
W
Szymczak
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002273:Carcinogens / Q000633:toxicity*; D004260:DNA Repair; D004912:Erythrocytes / Q000187:drug effects; D004928:Escin / Q000633:toxicity*; D005260:Female; D005273:Fenbendazole / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D002273:Carcinogens; D005273:Fenbendazole; D004928:Escin