Loss of the putative tumor suppressor-gene locus 1p36 as investigated by a PCR-assay and N-myc amplification in 48 neuroblastomas: results of the German Neuroblastoma Study Group.
48 primary neuroblastomas have been examined for an amplified N-myc and loss of the putative tumor suppressor-gene locus 1p36 by loss of heterozygosity studies (LOH 1p36). In 25% of these tumors N-myc amplification and/or a LOH 1p36 was detected, and these patients had a bad prognostic clinical outcome. 75% of the tumors neither had an amplified N-myc nor a LOH 1p36, and these patients had a much better prognosis. Thus, tumor genetic changes can subdivide two types of neuroblastoma with profound different clinical behavior. Detection of these genetic changes at diagnosis could help in front-line risk adapted therapy stratifications in neuroblastoma.
Christiansen
H
H
Universitäts-Kinderklinik, Giessen.
Delattre
O
O
Fuchs
S
S
Theobald
M
M
Christiansen
N M
NM
Berthold
F
F
Lampert
F
F
D001483:Base Sequence; D015139:Blotting, Southern; D002878:Chromosomes, Human, Pair 1; D017931:DNA Primers; D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics*; D005858:Germany; D006579:Heterozygote; D006801:Humans; D018598:Minisatellite Repeats; D008969:Molecular Sequence Data; D009447:Neuroblastoma / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods*
D017931:DNA Primers; D004273:DNA, Neoplasm