[The liver-protective properties of the pediatric drug form of propolis in animals of different age groups].
The pharmacological activity of a pediatric formulation of the phenolic hydrophobic drug propolis was studied in the experiments on albino rats of various age with toxic liver damages of various duration and in acute hepatic ischemia. In all models of hepatic abnormalities, the drug was found to show antioxidative properties which were moderate (30-60%). In addition, there were improvements in hepatic secretion of bile, cholic acids, and cholesterol. On the other hand, the membrane-stabilizing effect of the drug was exerted in not all the tested models of hepatic damage.
Drogovoz
S M
SM
Tikhonov
A I
AI
Slyshkov
V V
VV
Sal'nikova
S I
SI
D000208:Acute Disease; D000375:Aging / Q000187:drug effects*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007511:Ischemia / Q000188:drug therapy; D008099:Liver / Q000098:blood supply / Q000187:drug effects*; D011429:Propolis / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D011429:Propolis
Izuchenie gepatozashchitnykh svoĭstv detskoĭ lekarstvennoĭ formy propolisa u zhivotnykh raznykh vozrastnykh grupp.