Serum transferrin receptor and erythropoiesis in children with newly diagnosed acute lymphoblastic leukemia.
Thirty-five children with acute lymphoblastic leukemia were monitored weekly during the first 12 weeks of chemotherapy. The transferrin receptor (TfR) concentration was 2.8 +/- 0.2 mg/l (mean +/- S.E.M.) at diagnosis, decreased up to 3 weeks, and then increased reaching a maximal level at 8 weeks. The mean values for reticulocyte counts followed a similar pattern. In contrast, serum erythropoietin and ferritin levels were generally high. Those patients whose erythropoiesis was more accelerated had higher serum TfR concentrations. We conclude that among these patients the TfR level reflected the rate of erythropoiesis and was independent of the level of erythropoietin.
Children's Hospital, Research Laboratory, Children's Hospital, University of Helsinki, Finland.
S M
SM
Kivivuori
L
L
Viinikka
A M
AM
Teppo
M A
MA
Siimes
D002648:Child; D017707:Erythrocyte Transfusion; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000628:therapy; D011990:Receptors, Transferrin / Q000378:metabolism*; D017701:Reticulocyte Count; D012709:Serum Albumin / Q000378:metabolism
D011990:Receptors, Transferrin; D012709:Serum Albumin; D004921:Erythropoietin; D005293:Ferritins