Guillain-Barré syndrome after bone marrow transplantation.
A patient with chronic myeloid leukemia developed Guillain-Barré syndrome 4 months after allogeneic bone marrow transplantation. Clinical improvement occurred after a series of plasma exchanges. A relapse of the Guillain-Barré syndrome was also successfully treated with plasma exchange, with an eventual near-complete recovery. Reactivation of cytomegalovirus infection as manifested by antigenemia 2 months prior to the weakness was probably the precipitating event in this patient. We advocate early treatment of post-transplant Guillain-Barré syndrome with plasma exchange.
Leukemia Unit, Royal Marsden Hospital, Sutton, UK.
A
A
Perry
J
J
Mehta
T
T
Iveson
J
J
Treleaven
R
R
Powles
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000209:etiology; D006801:Humans; D015465:Leukemia, Myeloid, Accelerated Phase / Q000628:therapy; D008297:Male; D010951:Plasma Exchange; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000628:therapy; D012008:Recurrence; D014184:Transplantation, Homologous