Increased risk of facial scars in children taking nonsteroidal antiinflammatory drugs.
Children with rheumatic disease (N = 250) were examined for shallow facial scars similar to those described in drug-induced pseudoporphyria. Users of a nonsteroidal antiinflammatory drug were 2.4 times as likely as nonusers to have four or more facial scars; this relative risk was increased to 6.0 in users of naproxen.
Department of Pediatrics, University of Washington, Seattle.
C A
CA
Wallace
D
D
Farrow
D D
DD
Sherry
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000139:chemically induced* / Q000453:epidemiology; D003875:Drug Eruptions / Q000453:epidemiology / Q000209:etiology*; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009288:Naproxen / Q000009:adverse effects / Q000627:therapeutic use; D011164:Porphyrias / Q000139:chemically induced* / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D009288:Naproxen