Immunotherapeutic modification by an ayurvedic formulation Septilin.
Effect of Septilin, an ayurvedic formulation proven to be effective in the therapy of chronic infections, was investigated on the phagocytic system and humoral response in rats and mice. Septilin exhibited significant protection in E. coli-induced abdominal sepsis in normal mice and in Staphylococcus aureus-induced sepsis in neutropenic mice. It significantly reduced the viable E. coli cells when incubated with neutrophils in rats. Septilin stimulated the phagocytic function of the reticuloendothelial system in mice. In normal rats, Septilin enhanced anti-SRBC hemagglutination antibody titre by 5.7-fold and showed significant protection in cyclophosphamide-induced humoral suppression.
Rao
C S
CS
R & D Centre, Himalaya Drug Co, Makali, Bangalore, India.
Raju
C
C
Gopumadhavan
S
S
Chauhan
B L
BL
Kulkarni
R D
RD
Mitra
S K
SK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D007167:Immunotherapy / Q000379:methods*; D008515:Medicine, Ayurvedic; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; C047352:septilin