Fluoxetine and the serotonin syndrome.
A 48-year-old man presented to the emergency department with confusion, agitation, diaphoresis, and muscle rigidity after beginning treatment with fluoxetine, a serotonin reuptake inhibitor. He had discontinued treatment with tranylcypromine, a monoamine oxidase inhibitor, 2 weeks earlier. The constellation of findings was diagnostic of the serotonin syndrome.
Ruiz
F
F
Division of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia.
D017109:Akathisia, Drug-Induced / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D003221:Confusion / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D004359:Drug Therapy, Combination; D004635:Emergency Medicine; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013546:Sweating / Q000187:drug effects*; D013577:Syndrome; D014191:Tranylcypromine / Q000009:adverse effects*
D005473:Fluoxetine; D014191:Tranylcypromine