Histone-encoding genes from Pyrococcus: evidence for members of the HMf family of archaeal histones in a non-methanogenic Archaeon.
Two genes, designated hpyA1 and hpyA2, have been cloned and sequenced from Pyrococcus strain GB-3a. They are predicted to encode proteins (HPyA1 and HPyA2, respectively) that are approx. 60% identical to the histones HMf and HMt, characterized from methanogenic Archaea. These archaeal histones also contain the amino-acid sequences, conserved in eukaryotic H4 histones, that are thought to interact directly with DNA.
Sandman
K
K
Department of Microbiology, Ohio State University, Columbus 43210.
Perler
F B
FB
Reeve
J N
JN
D000595:Amino Acid Sequence; D001105:Archaea / Q000235:genetics*; D019843:Archaeal Proteins; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins / Q000235:genetics; D006657:Histones / Q000235:genetics*; D008969:Molecular Sequence Data
D019843:Archaeal Proteins; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; C065108:HMf protein, Archaeal; C090526:HPyA1 protein, Pyrococcus; C090527:HPyA2 protein, Pyrococcus; D006657:Histones