A new complex polymorphic repeat close to the HLA-A and HLA-E loci.
We describe a complex polymorphic repeat discovered analyzing YAC 225B1, which spans the region between the HLA-A and HLA-E loci. The repeat consists of a variable number of the nucleotide A followed by a variable number of the trinucleotide AAG [(A)n(AAG)n]. Three different alleles were detected with an observed heterozygosity of 0.30.
Totaro
A
A
Servizio di Genetica Medica, IRCCS-Ospedale CSS, San Giovanni Rotondo (FG), Italy.
Grifa
A
A
Roetto
A
A
Zelante
L
L
Camaschella
C
C
Gasparini
P
P
D000483:Alleles; D001483:Base Sequence; D005805:Genes, MHC Class I / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D000097625:HLA-E Antigens
D006680:HLA Antigens; D015234:HLA-A Antigens; D015395:Histocompatibility Antigens Class I; D009838:Oligodeoxyribonucleotides; D000097625:HLA-E Antigens