[The effect of gutimine and amtizol on the K, Na-pump activity of the nerve cell].
The antihypoxants gutimine and amtisole, its cyclic derivative of 3.5-diamino-1,thia-2,4-diazole were tested for their effects on the activity of one of the most power-consuming functions of a nerve cell--on the activity of the K, Na-pump during normoxia. Gutimine was found to decrease K, Na-pump activity in the Retzius neurone by an average of 70% presumably due to its inhibitory effects of leakage currents. The experiments suggest that the preventive protective effect of gutimine is displayed at the membranous level. Amtisole was found to unchange the functional activity of the K, Na-pump in the Retzius neurone.
Sergeeva
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D000818:Animals; D003864:Depression, Chemical; D004734:Energy Metabolism / Q000187:drug effects; D006164:Guanylthiourea / Q000494:pharmacology*; D066298:In Vitro Techniques; D007865:Leeches; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D011048:Polarography; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D013830:Thiadiazoles / Q000494:pharmacology*
D013830:Thiadiazoles; C044365:amtizol; D000254:Sodium-Potassium-Exchanging ATPase; D006164:Guanylthiourea
Vliianie gutimina i amtizola na aktivnost' K, Na-nasosa nervnoĭ kletki.