Nisamycin, a new manumycin group antibiotic from Streptomyces sp. K106. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
Nisamycin, a new manumycin group antibiotic, was isolated from the culture broth of Streptomyces sp. K106. This strain was designated to genus Streptomyces by the taxonomic features. Nisamycin was purified by ethyl acetate extraction, silica gel column chromatography, preparative silica gel TLC, and Sephadex LH-20 column chromatography as a pale yellow powder. Nisamycin is active against Gram-positive bacteria and fungi, and exhibits a cytotoxic activity.
Department of Agricultural Chemistry, Faculty of Agriculture, University of Osaka Prefecture, Japan.
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Hayashi
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Nakagawa
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Nakayama
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388 / Q000473:pathology; D008546:Melanoma, Experimental / Q000473:pathology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011090:Polyenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000166:cytology; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D011090:Polyenes; C085627:nisamycin