Interleukin-2 stimulates the secretion of arginine vasopressin but not corticotropin-releasing hormone from rat hypothalamic cells in vitro.
Cytokines are involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, thus providing a means of communication between the immune and neuroendocrine systems. In this study IL-2 caused a dose-dependent stimulation of AVP secretion from both the intact rat hypothalamus in vitro and hypothalamic cell cultures. IL-2 did not increase the secretion of CRH in either preparation, nor did it prime the cells to respond to a subsequent dose of IL-2. Both preparations, however, were able to respond to known CRH secretagogues such as 5-HT and 56 mM K+. This may provide yet another line of communication between the immune and neuroendocrine systems.
Department of Medicine, Bristol Royal Infirmary, UK.
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Hillhouse
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D002478:Cells, Cultured; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007376:Interleukin-2 / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013268:Stimulation, Chemical
D007376:Interleukin-2; D001127:Arginine Vasopressin; D012701:Serotonin; D003346:Corticotropin-Releasing Hormone; D011188:Potassium