Marine alkaloids, 15. Two alkaloids, flustramine E and debromoflustramine B, from the marine bryozoan Flustra foliacea.
A new alkaloid, flustramine E [1], with inhibitory activity towards Rhizotonia solani and Botrytis cinerea was isolated by gas-phase extraction from the marine bryozoan Flustra foliacea. The structure was determined as 3a,8a-cis-1-methyl-3a-(3-methyl-2- butenyl)-6-bromo-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole, based on spectroscopic investigations. Another alkaloid, debromoflustramine B [2a], was detected in trace amounts and identified by comparison of the mass spectrum with that of a synthetic sample. The extract also contained the previously reported alkaloids flustramine A and B in the ratio 1:7.
Holst
P B
PB
Marine Chemistry Section, H.C. Orsted Institute, University of Copenhagen, Denmark.
Anthoni
U
U
Christophersen
C
C
Nielsen
P H
PH
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002013:Bryozoa / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D026121:Indole Alkaloids; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D026121:Indole Alkaloids; C090331:debromoflustramine B; C090330:flustramine E