Discordant uptake of Tc-99m DTPA-galactosyl human serum albumin and Tc-99m Sn colloid in a patient with severe acute hepatitis.
A patient with recently diagnosed severe acute hepatitis underwent serial liver scintigraphy with Tc-99m Sn colloid and Tc-99m DTPA-galactosyl human serum albumin. In initial studies, radionuclide distribution on Tc-99m DTPA-galactosyl human serum albumin scintigraphy was completely discrepant to that on Tc-99m Sn colloid scintigraphy. In a follow-up study 1 month later, the distribution of both radionuclides in the liver appeared relatively homogeneous. The uptake of Tc-99m DTPA-galactosyl human serum albumin and Tc-99m Sn colloid reflects the function of hepatocytes and Kupffer cells, respectively. Both kinds of scintigraphic study may be helpful to assess histopathologic change of different hepatic tissue architectures.
Department of Diagnostic Radiology, Sapporo City General Hospital, Hokkaido, Japan.
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C
Miyazaki
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Matsunaga
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K
Kubo
D000208:Acute Disease; D000328:Adult; D003102:Colloids; D005260:Female; D005500:Follow-Up Studies; D006505:Hepatitis / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors; D017971:Tin Compounds; D015899:Tomography, Emission-Computed, Single-Photon
D003102:Colloids; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D017971:Tin Compounds; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; C033493:technetium Tc 99m tin colloid; D016284:Technetium Tc 99m Pentetate