Patterns of practice analysis for acute myocardial infarction.
OBJECTIVE
To assess the level of use of acetylsalicylic acid (ASA), beta-blockers and thrombolytic therapy--proven efficacious therapies in the management of acute myocardial infarction (AMI)--in contemporary patients admitted with AMI, and to assess the role of contraindications and other patient-specific factors in the use or nonuse of these treatments.


METHODS
The demographics and treatment course of patients admitted with a diagnosis of AMI were reviewed. Specifically targeted therapies were ASA, beta-blockers and thrombolytic therapy. Rates of use were calculated as 'gross utilization' (overall use) and 'adjusted utilization' (accounting for late presentation to hospital, initially equivocal diagnosis or contraindications).


METHODS
Tertiary care hospital in suburban Vancouver, British Columbia.


METHODS
A total of 372 consecutive patients admitted to Royal Columbian Hospital between September 1, 1990 and September 1, 1991.


METHODS
None.


RESULTS
Gross utilization of ASA, beta-blockers and thrombolytic therapy was 71, 31 and 21%, respectively. The adjusted utilization rates for early (6 h or less) treatment with ASA was 66%; with early beta-blockers, it was 18% and was 100% for thrombolytic therapy. Adjusted late (more than 6 h, to hospital discharge) use of ASA and beta-blockers was 84 and 57%, respectively.


CONCLUSIONS
With the exception of thrombolytic therapy, proven efficacious medical therapies for AMI appear underused at the study hospital. Ongoing educational efforts and continuing patterns of practice analyses are needed.
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver.
R T
RT
Tsuyuki
S
S
Gill
J D
JD
Hilton
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D000075202:Contraindications; D004363:Drug Utilization; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D018579:Patient Selection; D010818:Practice Patterns, Physicians'; D012189:Retrospective Studies; D015912:Thrombolytic Therapy
D000319:Adrenergic beta-Antagonists; D001241:Aspirin