Megaesophagus and hereditary nervous system degeneration.
A patient with a progressive, inherited disease of the CNS developed remarkable esophageal dilatation without the lower esophageal sphincter dysfunction characteristic of achalasia. Postmortem examination included neuropathologic study of the CNS and evaluation of esophageal myenteric plexus histology, but the pathogenesis of the megaesophagus remains unknown.
Department of Medicine, Southern California Permanente Medical Group, San Diego.
G F
GF
Longstreth
F D
FD
Walker
D000368:Aged; D004108:Dilatation, Pathologic; D004931:Esophageal Achalasia / Q000150:complications* / Q000473:pathology; D004947:Esophagus / Q000294:innervation / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D017827:Machado-Joseph Disease / Q000150:complications* / Q000473:pathology; D008297:Male