A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease.
We report a case of neural cell adhesion molecule (NCAM)-positive peripheral T-cell lymphoma (PTCL), pleomorphic, medium and large cell type according to the updated Kiel classification, which was associated with human T-cell lymphotrophic virus type 1 (HTLV-1). The patient showed an unusual involvement of the gastrointestinal tract forming a bulky mass during the course of his disease, and a relatively indolent clinical course for 53 months until death. Phenotypic analysis showed CD2+, CD3-, CD4+, CD5+, CD7+, CD8-, CD16-, CD56+, and CD57- phenotype. Human T-cell lymphotrophic virus type 1 antibody was detected by the enzyme-linked immunosorbent assay. The proviral integration of HTLV-1 and the monoclonal rearrangements of T-cell receptor beta and gamma genes also were confirmed in DNA extract from fresh material. This fact calls attention to NCAM as one of the potential factors playing a role in the localization and behavior of lymphomas even within the category of PTCL associated with HTLV-1, ie, adult T-cell leukemia/lymphoma (ATLL).
Hayashi
K
K
Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya, Japan.
Nakamura
S
S
Koshikawa
T
T
Kitoh
K
K
Koike
K
K
Komatsu
H
H
Kuroda
M
M
Kasahara
M
M
Ueda
R
R
Suchi
T
T
D000954:Antigens, Surface / Q000032:analysis*; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis*; D005770:Gastrointestinal Neoplasms / Q000150:complications*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology*; D039841:Leukocyte L1 Antigen Complex; D016411:Lymphoma, T-Cell, Peripheral; D008297:Male; D008875:Middle Aged
D000954:Antigens, Surface; D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex