A qualitative process theory based model of the HIV-1 virus-cell interaction.
We present a qualitative model of the interaction between the HIV-1 virus and the human cell, based on qualitative process theory. This model takes into account a previous qualitative model of the cell growth. The model presented here can be regarded as a first step for setting up a comprehensive model of the HIV-1 virus-cell interaction in which the possible points where a drug can attack the virus are evident. The first simulation trials indicate that the presented model reproduces (even though in a simplified way) the features of the real behaviour that have been considered in the modelling phase. Although our simulation is limited in the knowledge it expresses, it still gives a stimulating opportunity for the evaluation of the criteria chosen as discriminant in the interaction between virus and cell.
Department of Communications, Computer and System Sciences, University of Genova, Italy.
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C
Ruggiero
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Giacomini
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OE
Varnier
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S
Gaglio
D000998:Antiviral Agents / Q000627:therapeutic use; D001185:Artificial Intelligence; D002477:Cells / Q000187:drug effects / Q000821:virology*; D003198:Computer Simulation; D015967:Gene Expression Regulation, Viral; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015728:Receptors, HIV / Q000502:physiology; D016662:Virus Integration / Q000502:physiology; D017735:Virus Latency / Q000502:physiology; D014779:Virus Replication
D000998:Antiviral Agents; D015728:Receptors, HIV