[Effect of isoptin on toxic and cardiotonic effect of strophanthin K].
Two models of heart failure were used in rat experiments to study the effect of isoptin on tolerance to the toxic effect of k-strophanthin. Calcium antagonist-induced changes in the cardiotonic and chronotropic effects of the cardiac glycoside and myocardial oxygen consumption were examined in isolated frog atria with a movable-electrode electron tube and polarography. Isoptin was shown to substantially enhance tolerance to the toxic effect of k-strophanthin and slightly decrease positive inotropic effects of the cardiotonic, by slowing down its development rate. The agent potentiated the negative chronotropic action and lowered myocardial oxygen consumption.
S M
SM
Lemkina
D000818:Animals; D002303:Cardiac Output, Low / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D004347:Drug Interactions; D004567:Electrodes, Implanted; D006325:Heart Atria / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D011898:Ranidae; D051381:Rats; D017208:Rats, Wistar; D013328:Strophanthins / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D014700:Verapamil / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use
D013328:Strophanthins; D014700:Verapamil; C029082:strophanthin K
Vliianie izoptina na toksicheskiĭ i kardiotonicheskiĭ éffekty strofantina K.