Premarin-induced ischemic colitis.
There are numerous literature reports of oral contraceptive-induced (estrogen and progesterone) ischemic bowel disease. However, Premarin-induced (equine conjugated estrogen) intestinal ischemia has rarely been reported. We describe three cases of Premarin-induced ischemic colitis. In contrast to oral contraceptive-induced ischemic colitis, Premarin-induced ischemia is restricted to the colon, has not required surgical therapy, can have a chronic or chronic intermittent course, may be reversible despite continued usage of Premarin, and may present with nonspecific abdominal and colonic symptoms.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
A K
AK
Gurbuz
B
B
Gurbuz
L
L
Salas
N B
NB
Rosenshein
M
M
Donowitz
F M
FM
Giardiello
D000328:Adult; D017091:Colitis, Ischemic / Q000139:chemically induced*; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D004966:Estrogens, Conjugated (USP)