Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.
Reitz
D B
DB
Searle Research & Development, Chesterfield, Missouri 63198.
Li
J J
JJ
Norton
M B
MB
Reinhard
E J
EJ
Collins
J T
JT
Anderson
G D
GD
Gregory
S A
SA
Koboldt
C M
CM
Perkins
W E
WE
Seibert
K
K
D000284:Administration, Oral; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D003517:Cyclopentanes / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D051381:Rats
D016861:Cyclooxygenase Inhibitors; D003517:Cyclopentanes