Blunted oral body temperature response to MK-212 in cocaine addicts.
Previous studies have suggested that chronic cocaine administration may affect serotonergic function and that serotonin (5-HT) may be of importance in cocaine craving. Ten male cocaine addicts and 28 male normal controls were challenged with MK-212 (6-chlor-2-[1-piperazinyl]-pyrazine) (20 mg), a direct acting 5-HT receptor agonist which has affinity for a variety of 5-HT receptor subtypes, and placebo, on separate days. The plasma cortisol and prolactin (PRL) concentrations and oral body temperature responses to MK-212 and placebo were compared between groups. The temperature response to MK-212 was significantly blunted in cocaine addicts compared to normal controls. However, the plasma cortisol and PRL responses to MK-212 did not differ between the two groups. These results suggest selective alteration of presynaptic 5-HT1A or postsynaptic 5-HT2A/2C function in cocaine addicts.
Lee
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MA
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Meltzer
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D000328:Adult; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D003042:Cocaine; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D011719:Pyrazines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000503:physiopathology*
D011719:Pyrazines; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; C014896:6-chloro-2-(1-piperazinyl)pyrazine; D011388:Prolactin; D003042:Cocaine; D006854:Hydrocortisone