Assessment of factors II, VII, IX, X, and protein C in hepatosplenic schistosomiasis.
Forty-four patients with schistosomiasis mansoni were divided into two groups: a group of 31 patients with hepatosplenomegaly and a group of 13 patients with advanced hepatic fibrosis and ascites. Both groups were compared to a control group of 14 healthy subjects. Screening of the extrinsic and intrinsic coagulation pathways was performed by PT (%) and aPTT. Functional assays of vitamin-K-dependent coagulation proteins: factors II, VII, IX, X, and protein C were conducted by using standard methods. A progressive reduction in PT (%) and prolongation in aPTT were detected in the diseased groups. Furthermore, all studied coagulation proteins showed a progressive reduction in their activities, which became more pronounced in the group with advanced ascites. We conclude that the significant reduction in vitamin-K-dependent coagulation proteins might add to the coagulopathy and bleeding diathesis noted in patients infected with Schistosoma mansoni.
Department of Hematology, Theodor Bilharz Research Institute, Giza, Egypt.
H M
HM
Amin
S A
SA
Omran
N E
NE
el-Bassuoni
A H
AH
el-Kaliouby
S A
SA
el-Ashmawy
D000293:Adolescent; D000328:Adult; D001201:Ascites / Q000097:blood / Q000209:etiology; D001779:Blood Coagulation Factors / Q000032:analysis*; D002648:Child; D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D006474:Hemorrhagic Disorders / Q000209:etiology*; D006529:Hepatomegaly / Q000097:blood / Q000209:etiology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D011517:Prothrombin Time; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000150:complications; D013163:Splenomegaly / Q000097:blood / Q000209:etiology
D001779:Blood Coagulation Factors; D011486:Protein C; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X