Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad-spectrum antithrombotic agent.
Eldred
C D
CD
Department of Medicinal Chemistry, Glaxo Research and Development Ltd., Ware, England.
Evans
B
B
Hindley
S
S
Judkins
B D
BD
Kelly
H A
HA
Kitchin
J
J
Lumley
P
P
Porter
B
B
Ross
B C
BC
Smith
K J
KJ
D000284:Administration, Oral; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002144:Callithrix; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D005343:Fibrinolytic Agents; C090662:GR 144053; D010879:Piperazines; D010880:Piperidines; D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins