[Clinicopathological examination of the relation between Clara cells and smoking].
The relations between the number and cell area of Clara cells and smoking were examined in the lung tissue of 71 subjects by immunohistochemistry, using an anti-protein 1 antibody, which is a marker of Clara cells. The smokers showed significantly lower numbers of Clara cells than the non-smokers (p < 0.05). Although the mean non-smoking time in the ex-smokers was as long as 9 years, the ex-smokers showed a somewhat lower number of Clara cells than the non-smokers. The cell area of Clara cells was the same for smokers and non-smokers. We found that smoking reduces the number of Clara cells.
Department of Surgery Saiseikai Central Hospital, Tokyo, Japan.
H
H
Nomori
R
R
Kobayashi
R
R
Iga
G
G
Fuyuno
S
S
Morinaga
C
C
Torikata
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D005260:Female; D006801:Humans; D008168:Lung / Q000166:cytology*; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects*