[The analgesia effect and plasma corticosterone reaction during stress in adult rats treated neonatally with monosodium glutamate].
In the present investigation, it was found that the number of beta-endorphin (beta-END)-immunoreactive neurons of hypothalamic arcuate nucleus (ARC) in MSG-treated rats decreased by 60.7%. No significant differences in the baseline pain threshold and the baseline corticosterone (CS) level were observed between the MSG-treated group and the control group. After electrical foot shock for 30 min, the analgesia effect was decreased significantly (P < 0.001) in MSG-treated rats, while the CS levels of both MSG-treated rats and control rats were increased remarked (P < 0.01). The results suggest that the beta-END neurons of ARC were involved in analgesia, but not in CS reaction during stress.
Chen
Q L
QL
Department of Physiology, Suzhou Medical College.
Li
J H
JH
Liu
H C
HC
Gu
F
F
Yin
Q Z
QZ
D000818:Animals; D000831:Animals, Newborn; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D003345:Corticosterone / Q000097:blood*; D008297:Male; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology*; D013312:Stress, Physiological / Q000503:physiopathology*
D012970:Sodium Glutamate; D003345:Corticosterone