Equilibrium multigated blood pool ventriculography to evaluate the effects of high-dose gamma-globulin treatment for left ventricular functions in Kawasaki disease.
Twenty-one patients with acute state Kawasaki disease (15 boys, 6 girls; age range, 1-8 years) had equilibrium multigated blood pool ventriculography (EMBPV) before treatment. The symptoms and signs subsided after the administration of aspirin and the intravenous injection of high-dose (400 mg/kg per day x 5 days) gamma-globulin (IVGG) treatment. Then, a second EMBPV was arranged to evaluate the effects of the treatment on left ventricular functions. Left ventricular function was analyzed based on the following parameters: (systolic phase) ejection fraction, ejection time, peak ejection rate, first 1/3 ejection rate mean; and (diastolic phase) peak filling rate, fast filling fraction, time to peak filling rate, first 1/3 filling rate mean. The results showed that there were no significant differences in the parameters of left ventricular function before and after treatment (P > 0.05, paired Student's t-tests).
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
C H
CH
Kao
Y C
YC
Chen
K S
KS
Hsieh
S J
SJ
Wang
S H
SH
Yeh
D001241:Aspirin / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging* / Q000628:therapy*; D013670:Sodium Pertechnetate Tc 99m; D016277:Ventricular Function, Left / Q000502:physiology*
D016756:Immunoglobulins, Intravenous; D013670:Sodium Pertechnetate Tc 99m; D001241:Aspirin