Autosomal recessive congenital intrauterine infection-like syndrome of microcephaly, intracranial calcification, and CNS disease.
We present data on 10 patients from 5 families with a condition of microcephaly, intracranial calcification, and a clinical course resembling congenital TORCH infection. Repeatedly, negative TORCH investigations are a prerequisite for the identification of this disorder and the value of disturbed liver function and thrombocytopenia as aids to diagnosis is emphasised. Several similar families with recurrence of the disease in sibships are identified in the literature and the genetic implications of our observations are considered.
Reardon
W
W
Department of Pediatric Genetics, Hospital for Sick Children, London Hospital.
Hockey
A
A
Silberstein
P
P
Kendall
B
B
Farag
T I
TI
Swash
M
M
Stevenson
R
R
Baraitser
M
M
D001921:Brain / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000235:genetics*; D002114:Calcinosis / Q000235:genetics*; D002493:Central Nervous System Diseases / Q000235:genetics*; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000151:congenital; D005260:Female; D005808:Genes, Recessive; D006566:Herpesviridae Infections / Q000151:congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000235:genetics*; D010375:Pedigree; D014057:Tomography, X-Ray Computed; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis