Incidence of gram-negative bacteraemia in sepsis syndrome. Implications for immunotherapy.
The incidence of Gram-negative bacteraemia in 100 patients with sepsis syndrome receiving antibiotics, and admitted to the Intensive Therapy Unit, was only 12%. If endotoxin antibody is only effective in bacteraemic patients and these results are confirmed, there would be little indication for its use in our Intensive Therapy Unit.
Willatts
S M
SM
Intensive Therapy Unit, Bristol Royal Infirmary.
Speller
D C
DC
Winter
R J
RJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood / Q000453:epidemiology* / Q000628:therapy; D003422:Critical Care; D004311:Double-Blind Method; D004731:Endotoxins / Q000097:blood; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000150:complications*; D013654:Taurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013829:Thiadiazines / Q000627:therapeutic use
D000890:Anti-Infective Agents; D004731:Endotoxins; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine