Antibody response to adenovirus E1b-derived synthetic peptides and serum levels of p53 in patients with gastrointestinal and other malignant lymphomas.
Serum levels of p53 and antipeptide antibody levels to adenovirus type 12 (Ad12) E1b protein were measured in a case-control study of 62 newly diagnosed patients with malignant lymphoma. While patients with gastrointestinal lymphoma did not differ from their matched controls, p53 positive lymphoma patients had significantly (P < 0.04) increased antipeptide IgG antibody levels to the Ad12 E1b. Concomitant detection of serum p53 and antipeptide antibodies to Ad12 E1b was associated with an increased risk (OR = 17.0, 95% confidence limits 1.5, 58.5) of malignant lymphoma suggesting synergism between expression of Ad12 E1b and accumulation of p53 in patients with malignant lymphoma.
Lähdeaho
M L
ML
Department of Biomedical Sciences, University of Tampere, Finland.
Lehtinen
T
T
Aine
R
R
Hakala
T
T
Lehtinen
M
M
D017501:Adenovirus E1B Proteins / Q000737:chemistry / Q000276:immunology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood*; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
D017501:Adenovirus E1B Proteins; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D010455:Peptides; D016159:Tumor Suppressor Protein p53