Do specific pockets of HLA-C molecules predispose Jewish patients to psoriasis vulgaris?
BACKGROUND
Psoriasis vulgaris was reported to be associated with a specific alanine residue at position 73 of HLA-C alleles in Japanese patients.


OBJECTIVE
Our purpose was to determine the role of HLA genes in susceptibility to psoriasis vulgaris in the Israeli Jewish population.


METHODS
Twenty-eight Israeli patients were analyzed for their HLA class I and II specificities by means of serologic and molecular methods.


RESULTS
All patients possessed in their HLA-C antigens an alanine residue at position 73 (p < 0.002). A significantly increased frequency of HLA-Cw6 and of Cw7 was also observed among the patients (p < 0.02).


CONCLUSIONS
Our study clearly shows that alanine in position 73 is significantly associated with psoriasis vulgaris in Jewish patients. Cw6 and Cw7 have a unique antigen-binding pocket containing both alanine at position 73 and a negatively charged aspartic acid at position 9. These residues are most probably important in determining the conformation of the C pocket and in turn the nature of the peptide bound to it. We suggest that this combination confers the highest risk of the development of psoriasis vulgaris.
Lautenberg Center for General and Tumor Immunology, Hadassah University Hospital, Jerusalem, Israel.
A
A
Roitberg-Tambur
A
A
Friedmann
E E
EE
Tzfoni
S
S
Battat
R
R
Ben Hammo
C
C
Safirman
K
K
Tokunaga
A
A
Asahina
C
C
Brautbar
D000409:Alanine / Q000235:genetics; D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007557:Israel; D007585:Jews / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*
D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; C040178:HLA-C*70 antigen; D001224:Aspartic Acid; D004247:DNA; D000409:Alanine