Aspirin toxicity in chicks given diets deficient in linoleic acid.
The toxicity of dietary aspirin on growth rate and lipid metabolism was investigated under linoleic acid (LA; 18: 2n-6) deficient conditions. One-week-old chicks were given diets containing 0 or 2% LA with or without 0.4% aspirin, until 4 weeks of age. Growth was severely depressed by dietary aspirin when chicks were given the LA-free diet. The liver was enlarged by both the aspirin and LA deficiency. The aspirin treatment induced a significant increase of 18:0 and arachidonic acid (20: 4n-6) and a decrease of 18: 1n-9 in the liver. In chicks fed LA-free diets, the ratio of 20:3n-9/20: 4n-6, which was used as an indicator of LA deficiency, was suppressed by aspirin treatment. In conclusion, the present results suggest that aspirin toxicity is altered by dietary LA concentrations.
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
A
A
Murai
M
M
Furuse
J
J
Okumura
D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D002645:Chickens; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004435:Eating / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D008041:Linoleic Acids / Q000172:deficiency*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects
D005227:Fatty Acids; D008041:Linoleic Acids; D002784:Cholesterol; D001241:Aspirin