[Two cases of asymptomatic primary biliary cirrhosis (PBC) accompanied with CREST syndrome].
Two cases of asymptomatic primary biliary cirrhosis (PBC) combining CREST syndrome. We have had encountered two primary biliary cirrhosis (PBC) patients overlapped with CREST syndrome. Case 1 was a 51-year-old female, who was suffering from Raynaud's phenomenon, esophageal dysmotility and sclerodactyly. Case 2 was a 67-year-old female, who was suffering from Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia. They were free from itching and icterus. The histology of their biopsied liver specimen should stage I-II of Scheuer's classification. Their immunological findings showed anti-centromere antibody, (ACA) at a high titer (1 : 1280 dilution) and anti-mitochondrial antibody (AMA) at a low titer (1 : 40 dilution) positive in both. HLA DR types included DR2 and DRW8 in case 1, and did DR1 and DRW6 in case 2. Both patients are having good prognosis.
Department of Internal Medicine, Ohota Nishinouchi Hospital, Fukushima.
I
I
Takeda
S
S
Igarashi
H
H
Oyanagi
A
A
Irisawa
S
S
Mukai
I
I
Shoji
H
H
Sakuma
H
H
Satho
K
K
Sekine
M
M
Kuroda
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D017675:CREST Syndrome / Q000150:complications*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008875:Middle Aged
D001323:Autoantibodies