Direct correlation between the titer of infectious bursal disease virus VP2-specific antibody and protection.
The titer of antibody specific to infectious bursal disease virus (IBDV) was measured by a new method and correlated with protection. Challenge was carried out in chickens with various antibody titers, which were measured using a latex agglutination-inhibition (LI) test, a rapid and easy technique for measuring IBDV VP2-specific antibody. When actively immunized chickens had LI titers of 1:2 or more, almost all were protected from subsequent challenge with highly virulent IBDV. In contrast, even when chickens passively immunized with maternally derived antibody had LI titers of 1:4, half were susceptible to the same challenge.
Nakamura
T
T
Nippon Institute for Biological Science, Tokyo, Japan.
Otaki
Y
Y
Lin
Z
Z
Nunoya
T
T
Hoshi
S
S
Kato
A
A
D000372:Agglutination Tests; D000375:Aging / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D018175:Birnaviridae Infections / Q000276:immunology; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology* / Q000382:microbiology; D005260:Female; D005347:Fibroblasts; D007114:Immunization; D007243:Infectious bursal disease virus / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D015678:Viral Structural Proteins / Q000276:immunology*
D000914:Antibodies, Viral; C082513:VP2 protein, infectious bursal disease virus; D015678:Viral Structural Proteins