An open study of procaine penicillin G, clavulanate-potentiated amoxycillin and probenecid in the treatment of acute gonorrhoea.
In an open study 55 patients presenting with acute gonorrhoea were given 4.8 mega units procaine penicillin G, intramuscularly, and oral probenecid (1 g) plus one 375-mg tablet clavulanate-potentiated amoxycillin orally. Before this treatment, 53 patients (96.4%) had presented with a purulent discharge, and dysuria was present in 47 patients (85.5%). The presence of Neisseria gonorrhoeae was confirmed by bacterial culture in 54 patients (98.2%). The majority of pathogens (92.5%) were penicillin resistant. On day 3 after treatment, dysuria was absent in 53 patients (96.4%) and there was no discharge in 40 cases (72.7%). N. gonorrhoeae was eradicated in 53 patients (96.4%). Two further patients were bacteriologically cured, but were suffering from post-gonococcal urethritis. The patients in whom discharge was still apparent were further assessed on day 7; discharge was resolved or resolving in all but one patient. There was one treatment failure. No adverse reactions were reported.
University Department of Surgery, College of Medical Sciences, University of Calabar, Nigeria.
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Ekwere
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000627:therapeutic use*; D011339:Probenecid / Q000008:administration & dosage / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D010402:Penicillin G Procaine; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D011339:Probenecid