Relationships between serum lipids, serotonin, platelet aggregation and some fibrinolytic parameters in humans.
We have studied relationships between serum lipids, plasma serotonin (5-hydroxytryptamine, 5-HT), platelet aggregation in the platelet-rich plasma (PRP), and some fibrinolytic parameters in healthy volunteers. LDL was positively related to 5-HT-induced platelet aggregation. Higher serum HDL levels were related to higher fibrinolytic activity expressed by shorter euglobulin clot lysis time (ECLT). No correlation existed between serum lipids and plasma 5-HT. Plasma 5-HT was found to be related to tissue plasminogen activator (t-PA), suggesting some link between plasma serotonin and the release of t-PA from endothelial cells. There were mutual relations among fibrinolytic parameters such as tissue plasminogen activator (t-PA) antigens, total plasminogen activator inhibitor-1 (PAI-1), t-PA-PAI-1 complex, free PAI-1, and ECLT. In conclusion higher LDL may be more thrombogenic due to enhanced 5-HT induced platelet aggregation whereas high HDL may be more protective against thrombosis due to enhancement of fibrinolysis.
Department of Physiology, Hamamatsu University School of Medicine, Japan.
J
J
Malyszko
T
T
Urano
R
R
Knofler
H
H
Ihara
Y
Y
Takada
A
A
Takada
D000328:Adult; D002784:Cholesterol / Q000097:blood; D005342:Fibrinolysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010974:Platelet Aggregation; D012701:Serotonin / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood
D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D017395:Plasminogen Activator Inhibitor 1; D012701:Serotonin; D002784:Cholesterol; D010959:Tissue Plasminogen Activator