Human monoclonal antibodies: recent achievements.
The latest developments include an anti-HIV antibody that has 1,000 times the affinity of natural antibody and that neutralizes primary clinical isolates, and an anti-RSV antibody that reduces viral titers in mice by 12,000-fold within 24 hours.
Burton
D R
DR
Department of Immunology, Scripps Research Institute, La Jolla, Calif.
Barbas
C F
CF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000915:Antibody Affinity; D005821:Genetic Techniques; D006678:HIV / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D006801:Humans; D051379:Mice; D012136:Respiratory Syncytial Viruses / Q000276:immunology
D000911:Antibodies, Monoclonal; D015699:HIV Envelope Protein gp120