[Experimental pharmacokinetic studies of carboplatin intraperitoneal chemotherapy].
High performance liquid chromatography was used to study the performances of carboplatin by intraperitoneal (ip) administration in six dogs. 30 mg/kg carboplatin in 500ml 0.9% sodium chloride was injected ip quickly. Drug levels in the peritoneal fluid and blood of the portal vein and femoral vein were measured at different time intervals. The results showed a high drug concentration in the peritoneal fluid within 240 minutes after large dose and volume of carboplatin administered ip. The peak and mean concentrations of carboplatin in the peritoneal fluid were 139 and 64 times that of blood in the femoral vein, respectively. The peak and mean concentrations of the drug in the portal vein were 13.3 and 6.8 times those in the femoral vein. Intraperitoneal chemotherapy of carboplatin can maintain a stable and persistent high drug level in the peritoneal cavity, portal vein as well as liver. Systemic toxic effects were decreased due to low level of drug in the systemic circulation. These pharmacokinetic properties of carboplatin are of advantage in preventing and treating tumor recurrence in the peritoneal cavity and hepatic metastases.
Cancer Institute, China Medical University, Shenyang.
J
J
Wang
J Q
JQ
Chen
D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D016190:Carboplatin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D005260:Female; D005268:Femoral Vein / Q000378:metabolism; D007263:Infusions, Parenteral; D008297:Male; D011169:Portal Vein / Q000378:metabolism
D016190:Carboplatin