[Andrologic variables for in vitro fertilization].
The purpose of the study was to identify semen parameters relevant for in vitro fertilization (IVF). A total of 151 ejaculates from 130 patients were analyzed. There was a significant association between successful IVF, high sperm concentration and good sperm motility. Progressive sperm motility correlated best with successful fertilization of oocytes (r = +0.427) and was the only parameter significantly linked to pregnancy. Very low values were sufficient for fertilization in vitro: a sperm concentration of 4.5 x 10(6)/ml and a progressive sperm motility of 20%. The results of analysis of fructose, citrate and neutral alpha-glucosidase as markers of seminal vesicle, prostate and epididymal functions were not different in fertilizing and non-fertilizing semen samples. Moderate increases in granulocyte elastase levels, between 250 and 1000 ng/ml, did not influence IVF. However, two patients with genital tract inflammation (PMN-elastase > 1000 ng/ml) did not fertilize despite excellent semen parameters. These results stress the importance of andrological factors for in vitro fertilization outcome.
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
H
H
Wolff
T
T
Mögele
G
G
Bezold
W
W
Bollmann
T
T
Brückner
U
U
Noss
M
M
Meurer
D000328:Adult; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D005260:Female; D005307:Fertilization in Vitro; D005632:Fructose / Q000378:metabolism; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000378:metabolism; D011247:Pregnancy; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*; D013084:Sperm-Ovum Interactions / Q000502:physiology*; D014019:Tissue Donors; D016896:Treatment Outcome; D000520:alpha-Glucosidases / Q000378:metabolism
D002951:Citrates; D019343:Citric Acid; D005632:Fructose; D000520:alpha-Glucosidases; D010196:Pancreatic Elastase
Andrologische Einflussfaktoren der In-vitro-Fertilisation.