Hypocrellin, from Hypocrella bambuase, is phototoxic to human immunodeficiency virus.
Hypocrellin, a photodynamic perylene quinonoid isolated from the Chinese medicinal fungus Hypocrella bambuase, was evaluated for antiviral activity against the human immunodeficiency virus (HIV-1). Hypocrellin was phototoxic to HIV-1, almost as good as the structurally similar plant pigment hypericin, and like hypericin its activity required visible light. In contrast peroxyhypocrellin had little or no effect on the virus.
Hudson
J B
JB
Department of Pathology, University of British Columbia, Vancouver, Canada.
Zhou
J
J
Chen
J
J
Harris
L
L
Yip
L
L
Towers
G H
GH
D016475:3T3 Cells; D000818:Animals; D000873:Anthracenes; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects* / Q000528:radiation effects; D003624:Darkness; D015497:HIV-1 / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D006999:Hypocreales / Q000737:chemistry; D008027:Light; D051379:Mice; D010569:Perylene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D019800:Phenol; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology
D000873:Anthracenes; D000998:Antiviral Agents; D011809:Quinones; D011838:Radiation-Sensitizing Agents; D019800:Phenol; D010569:Perylene; C004965:hypericin; C090289:peroxyhypocrellin; C048388:hypocrellin A