Primary anetoderma: phagocytosis of elastic fibres by macrophages.
We report a 22-year-old female with a 2-year history of increasingly numerous well-circumscribed, asymptomatic skin lesions. The clinical and histological features were consistent with anetoderma and investigations failed to reveal any associated underlying disorders. Electron microscopy of abnormal skin showed phagocytosis of elastic fibres by macrophages. Although the aetiology of primary anetoderma remains unknown, this finding suggests that phagocytic destruction of elastic fibres plays a major role in its pathogenesis.
Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, UK.
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I
Zaki
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Scerri
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Nelson
D000328:Adult; D003240:Connective Tissue Diseases / Q000209:etiology / Q000473:pathology; D004547:Elastic Tissue / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000502:physiology* / Q000648:ultrastructure; D010587:Phagocytosis / Q000502:physiology*; D012867:Skin / Q000648:ultrastructure