Induction of Fos protein in the piriform cortex after brain injury in pentobarbital-anaesthetized rats: lack of effect of lactation.
The ability of lactation and progesterone administration to inhibit the induction of Fos protein in the piriform cortex after brain injury in pentobarbital-anaesthetized rats was assessed in three studies. Consistent with previous reports we found that brain injury-induced Fos expression in the piriform cortex could be eliminated by the administration of the non-competitive NMDA receptor antagonist MK 801 (4 mg/kg i.p.). Fos induction was not reduced, however, in lactating dams (days 7-9) post-partum or in progesterone-treated males. These results are not consistent with the hypothesis that suckling stimulation and progesterone have a direct effect at the NMDA receptor complex.
Department of Psychology, Concordia University, Montreal, Que., Canada.
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Amir
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Robinson
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Woodside
D000758:Anesthesia; D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005260:Female; D007774:Lactation / Q000502:physiology*; D008297:Male; D010424:Pentobarbital; D011374:Progesterone / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D016760:Proto-Oncogene Proteins c-fos; D016194:Receptors, N-Methyl-D-Aspartate; D011374:Progesterone; D016291:Dizocilpine Maleate; D010424:Pentobarbital