Cellular immune responses in rhesus macaques infected rectally with low dose simian immunodeficiency virus.
Monkeys infected rectally with low dose simian immunodeficiency virus (SIV) were resistant to high dose challenge with SIV. Peripheral blood mononuclear cells (PBMC) from two of four challenged monkeys were unable to support SIV replication in vitro unless cultures were depleted of CD8+ lymphocytes. Monkeys that had survived high dose rectal infection with SIV also suppressed virus replication in cultured PBMC. PBMC from uninfected monkeys supported virus replication in both unfractionated and CD8-depleted cultures. Virus-suppressive activity of PBMC may be an important correlate of protective immunity in AIDS.
Dept. of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53707.
M S
MS
Salvato
P
P
Emau
M
M
Malkovsky
K T
KT
Schultz
E
E
Johnson
C D
CD
Pauza
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008253:Macaca mulatta; D012007:Rectum; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D014779:Virus Replication