[Effect of saccharol glycosides on energy metabolism in animals with abnormal carbohydrate tolerance].
A trial has been performed of a new sweetening agent saccharol, glycosides complex, on energy metabolism in rats with experimental alloxan diabetes. Elevated glucose level observed in rats with insulin insufficiency was associated with hexokinase activity inhibition and changes in the activity of the enzymes involved in glucose-6-phosphate transformation: enhanced activity of glucose-6-phosphatase and glucose-6-phosphate dehydrogenase against inhibition of phosphoglucomutase activity. Introduction of saccharose aggravated the above shifts in the rat liver, whereas saccharol possesses a protective action on hexokinase hepatic reaction and enzymes of glucose-6-phosphate conversion, reduced blood glucose. Positive changes induced by saccharol on energy metabolism in animals with insulin insufficiency can be attributed to the effect of saccharol glycosides.
V i
Vi
Smoliar
E V
EV
Tsapko
E D
ED
Karpilovskaia
M B
MB
Pliss
N S
NS
Saliĭ
S N
SN
Grigorenko
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy* / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D019298:Glucose-6-Phosphate; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D006027:Glycosides / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010733:Phosphoglucomutase / Q000378:metabolism; D051381:Rats; D012439:Saccharin / Q000494:pharmacology / Q000627:therapeutic use*; D013395:Sucrose / Q000378:metabolism
D001786:Blood Glucose; D005958:Glucosephosphates; D006027:Glycosides; D019298:Glucose-6-Phosphate; D013395:Sucrose; D000496:Alloxan; D005954:Glucosephosphate Dehydrogenase; D005952:Glucose-6-Phosphatase; D010733:Phosphoglucomutase; D012439:Saccharin
Vliianie glikozidov sakharola na énergeticheskiĭ obmen u zhivotnykh s narushennoĭ tolerantnostíu k uglevodam.