Autoimmune disease. Gadding around the beta cell.
Recent studies shed new light on the process by which T-cell tolerance to pancreatic beta-cell antigens breaks down, leading to the autoimmune disease insulin-dependent diabetes mellitus.
Cooke
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Department of Pathology, Cambridge University, UK.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD; D008822:Mice, Transgenic; D008954:Models, Biological; D013601:T-Lymphocytes / Q000276:immunology*
D005968:Glutamate Decarboxylase