Low plasma 19-hydroxyandrostenedione levels in patients with aldosterone-producing adenoma.
The present study was performed to clarify changes in plasma levels of 19-hydroxyandrostenedione (19-OH-AD), an amplifier of aldosterone and a possible hypertensinogenic steroid, during several tests for the renin-angiotensin system in 20 patients with aldosterone-producing adenoma (APA) and to determine whether 19-OH-AD participates in the etiology of the hypertension in this disorder. Basal plasma 19-OH-AD levels in patients with APA were significantly lower than those in 50 normal subjects, and correlated positively with basal plasma cortisol levels (r = 0.45, P < 0.05). Plasma 19-OH-AD levels were not changed significantly by 2-h standing during which plasma renin activity (PRA) remained suppressed. With 40 mg iv furosemide plus 2-h standing during which PRA remained suppressed, plasma 19-OH-AD levels increased significantly with a concomitant significant increase in plasma cortisol. With dexamethasone pretreatment, however, such positive responses of plasma 19-OH-AD and cortisol disappeared. After the removal of the APA with the adjacent adrenal tissue, PRA and plasma aldosterone concentrations became normal or low-normal, but plasma 19-OH-AD and cortisol did not change as compared with the preoperative levels. There were no significant correlations between basal plasma 19-OH-AD levels and mean blood pressure either before or after the adrenal operation.(ABSTRACT TRUNCATED AT 250 WORDS)
Morita
H
H
Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
Mune
T
T
Yasuda
K
K
Yamakita
N
N
Miyazaki
S
S
Miura
K
K
D000236:Adenoma / Q000097:blood* / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000150:complications; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D000735:Androstenedione / Q000031:analogs & derivatives* / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000735:Androstenedione; D000450:Aldosterone; D005665:Furosemide; D003907:Dexamethasone; C011482:19-hydroxy-4-androstene-3,17-dione