[Relation of DNA content to biological characteristics and prognosis in advanced gastric carcinoma].
Cellular DNA ploidy and S-phase fraction from 57 advanced gastric carcinomas were measured by flow cytometry. The relation of DNA ploidy and S-phase fraction to pathological factors and prognosis were also analyzed. The results showed that the incidence of lymph node metastasis in nondiploid carcinoma was substantially higher than that in diploid carcinoma (P < 0.05). Most of the gastric carcinomas with low S-phase fraction were stage II tumors, had no lymph node metastasis, presented expanding growth and had not invaded the serosa (P < 0.05 respectively). The patients with low S-phase fraction carcinoma had remarkably better survival than those with high S-phase fraction (P < 0.01). Multivariate analysis of Cox model demonstrated that S-phase fraction was the best prognostic factor.
Li
J Y
JY
Department of General Surgery, 304 Hospital of PLA, Beijing.
Lu
L R
LR
Zhang
S X
SX
D000230:Adenocarcinoma / Q000235:genetics; D002288:Adenocarcinoma, Mucinous / Q000235:genetics; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016196:S Phase; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm