Immunology and disease control: a systems approach.
The application of system theory (or more precisely, differential equations) to immunology and disease, in general, is presented here. Particular results from U.S.-Russian research collaboration depict the potential role of such systematic analysis for more effective health care and disease control. In particular, some emphasis is given to control of influenza. After a brief systematic overview of immunology, a simple infectious disease model is developed to explain four basic forms of disease: subclinical, acute, lethal and chronic. Then, disease treatment is studied.
Asachenkov
A L
AL
International Institute for Applied Systems Analysis, Department of Systems and Decision Sciences, Laxenburg, Austria.
Marchuk
G I
GI
Mohler
R R
RR
Zuev
S M
SM
D000208:Acute Disease; D002908:Chronic Disease; D003141:Communicable Diseases / Q000276:immunology* / Q000628:therapy; D003198:Computer Simulation; D006801:Humans; D007251:Influenza, Human / Q000276:immunology* / Q000628:therapy; D008954:Models, Biological; D013598:Systems Theory