Sequential change of brain edema by semiquantitative measurement on MRI in patients with hypertensive intracerebral hemorrhage.
The progression of brain edema in seven patients with hypertensive intracerebral hemorrhage (ICH) was evaluated. Five were of putaminal and two were of thalamic hemorrhage. The hematoma volume in the patients was 4 approximately 40 ml (18.9 +/- 8.0 ml). Sequential MRI (SE: 2000/40) was performed at one, two and four weeks after onset. The edema volume (EV) was calculated as 1/2.(long diameter).(short diameter).(thickness) of the high intensity area (HIA) on MRI. In comparison with the EV at one week after onset, the EV at two weeks was increased and the EV at four weeks returned to the same level of that at one week (132.3 +/- 26.1%, 100 +/- 10.6%, respectively). In contrast, the consciousness level and motor weakness of the patients had already improved at two weeks after onset. Our results demonstrate that progression of brain edema after small or medium size ICH may not bring about a deterioration of the clinical course. Moreover, progression of brain edema to the cerebral cortex and ventricle as indicated by MRI suggested an absorption pathway for the edema fluid, and implying that brain edema following ICH could play a part in the healing process after ICH.
Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Gunma, Japan.
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S
Suga
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S
Sato
K
K
Yunoki
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B
Mihara
D000368:Aged; D001925:Brain Damage, Chronic / Q000473:pathology; D001929:Brain Edema / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011699:Putamen / Q000473:pathology; D013788:Thalamus / Q000473:pathology; D014057:Tomography, X-Ray Computed