Immunocytochemical mapping of a novel dopamine-releasing protein in the rat brain.
This report partially describes, for the first time, the immunocytochemical distribution of a novel dopamine-releasing protein (DARP) in the male rat brain. This glycoprotein detected specifically with a monoclonal antibody against DARP follows a close distribution to that of catecholamines (CA) in areas in the CNS rich in either CA fibers or CA neuron cell groups as previously reported by others using a tyrosine hydroxylase (TH) marker. The striking similarities in the topographic arrangement of the DARP-positive reaction product and the TH-positive reaction product is another argument favoring the view that DARP is involved in the regulation of catecholamine neurons.
Department of Anatomy, Gyeongsang National University, Chinju, Korea.
W S
WS
Choi
B H
BH
Lee
V D
VD
Ramirez
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002395:Catecholamines; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C058043:dopamine-releasing factor, rat; D014446:Tyrosine 3-Monooxygenase