Radiation therapy of localized prostate cancer.
External beam radiation therapy is an effective, well tolerated treatment modality for localized prostate cancer with a low rate of severe morbidity. In this retrospective analysis experience with 431 patients who have been treated with definitive radiation therapy with aim at cure is presented. Median follow-up time was 4 years (range 1-17 years). Treatment was administered with 45 mega Volt photons in all cases. Does between 60-70 Gray to the prostate and 45-50 Gray to the pelvic lymph nodes have been applied. Disease-free survival rates approaching 80% in 5 years and 53% in 10 years have been achieved for disease confined to the prostate as compared to 50% at 5 years and 27% at 10 years for extracapsular disease. The prognostic significance of various factors such as stage, grade, lymph node status, method of diagnosis, and pretreatment prostate-specific antigen value has been documented and analysed. Comparison of results with those of radical prostatectomy is discussed.
Landmann
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Department of Radiation-Oncology, University Hospital Petersgraben, Basel, Suisse.
D000206:Actuarial Analysis; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009919:Orchiectomy; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome