[Effect of nifedipine and verapamil on the interaction of arterial and venous systemic hemodynamics].
Electromagnetic flowmetry and analogue computers were used to evaluate changes in great venous and arterial blood flow and resistance alterations in the vessels after nifedipine and verapamil in experiments with 12 anesthesized cats. The agents were demonstrated to increase cardiac output due to lower afterload and venous return, to redistribute cardiac output towards greater brain blood supply. The latter was caused by a more marked decrease in vascular resistance in the brachiocephalic arterial tree than in the descending thoracic artery. Blood flow changes in the great arteries determined those in the vena cava superior and inferior.
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Kostko
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D016122:Brachiocephalic Trunk / Q000502:physiology*; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D055590:Electromagnetic Phenomena; D006439:Hemodynamics / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology*; D012212:Rheology; D013895:Thoracic Arteries / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects; D014682:Vena Cava, Inferior / Q000502:physiology*; D014683:Vena Cava, Superior / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D009543:Nifedipine
Vzaimodeĭstvie osnovnykh parametrov arterialńogo i venoznogo otdelov sistemnoĭ gemodinamiki pri primenenii nifedipina i verapamila.