Growth factors and ocular wound healing.
Protein growth factors regulate many of the processes in vitro that are essential for the process of normal ocular wound healing, including migration, mitosis and differentiation of cells. This has led to the hypothesis that peptide growth factors play key roles in regulating normal ocular wound healing in vivo. A corollary to this concept is that insufficient action of growth factors causes impaired healing, and prolonged action of growth factors produces excessive scarring. If both of these concepts are correct, then the addition of exogenous protein growth factors should enhance healing of chronic ocular wounds and reducing prolonged actions of growth factors should limit excessive scarring. Although much remains to be understood about the role of growth factors in ocular development and wound healing, results of a substantial number of laboratory and clinical experiments indicate that these hypotheses are generally correct. This article reviews the results of pre-clinical experiments and clinical trials investigating the roles of protein growth factors in ocular development and wound healing.
Department of Obstetrics/Gynaecology, University of Florida, Gainesville 32610-0294.
G
G
Schultz
P T
PT
Khaw
K
K
Oxford
S
S
MaCauley
G
G
Van Setten
N
N
Chegini
D000818:Animals; D065306:Corneal Injuries; D004728:Endothelium, Corneal / Q000293:injuries; D004815:Epidermal Growth Factor / Q000502:physiology / Q000627:therapeutic use; D005131:Eye Injuries / Q000628:therapy; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D051379:Mice; D011817:Rabbits; D016211:Transforming Growth Factor alpha / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D006133:Growth Substances; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor