[A patient with Guillain-Barré syndrome in association with Campylobacter jejuni enteritis (PEN19:LIO7) in a patient with HLA-B52 antigen].
We report a 15-year-old boy with Guillain-Barré syndrome (GBS) in association with Campylobacter jejuni enteritis. A neurologic examination revealed distal-dominant weakness and areflexia. Compound muscle action potentials were markedly reduced in amplitude, but the decrease in motor conduction velocities was slight. C. jejuni was isolated from his stool culture and the serotype belonged to PEN19:LIO7. Thin-layer chromatography-immunostaining showed that his serum IgG reacted strongly with GM1 and weakly with GD1b. The patient had HLA-B52 antigen, whose epitope is very similar to that of B35 antigen.
Third Department of Internal Medicine, National Defence Medical College.
K
K
Kaida
N
N
Yuki
M
M
Takahashi
K
K
Kamakura
N
N
Nagata
D000293:Adolescent; D002169:Campylobacter Infections; D016123:Campylobacter jejuni / Q000145:classification / Q000302:isolation & purification*; D005677:G(M1) Ganglioside / Q000276:immunology; D015235:HLA-B Antigens / Q000032:analysis*; D059950:HLA-B52 Antigen; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D011129:Polyradiculoneuropathy / Q000276:immunology / Q000382:microbiology*; D012703:Serotyping
D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside