Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
Central histaminergic modulation of H1 rather than H2-receptors has been shown to modify epileptic activity. Compounds acting on the HIC- and H3-receptors were tested against chemically-induced seizures in mice. Compounds antagonising the microsomal and nuclear intracellular receptors (HIC) only modified seizures at doses where toxicity was observed. Antagonists of the histamine H3-receptor (thioperamide and burimamide) only potentiated the severity of clonic convulsions induced by picrotoxin, while impromidine (i.c.v.), an antagonist with H2-agonist activity, inhibited leptazol-induced seizures. The H3-agonist, (R)alpha-methylhistamine, potentiated chemically-induced seizures, but at lower doses there was slight inhibition.
Department of Life Sciences, University of East London, UK.
G
G
Sturman
P
P
Freeman
H M
HM
Meade
N A
NA
Seeley
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003292:Convulsants / Q000494:pharmacology; D017442:Histamine Agonists; D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D010433:Pentylenetetrazole; D010852:Picrotoxin; D018100:Receptors, Histamine H3 / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced*
D000927:Anticonvulsants; D003292:Convulsants; D017442:Histamine Agonists; D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D010433:Pentylenetetrazole; D010852:Picrotoxin; D018100:Receptors, Histamine H3