The effect of various contrast media on the activation of plasminogen by streptokinase or recombinant tissue plasminogen activator in vitro.
OBJECTIVE
Radiologic contrast media (CM) may influence processes of coagulation and fibrinolysis. In the current study, the effects of various CM on the formation of plasmin were examined in an in vitro buffer system.


METHODS
The effects of three clinically relevant concentrations of seven different iodine-containing CM and gadolinium-DTPA on streptokinase (SK) or recombinant tissue plasminogen activator (rt-PA)-induced plasmin formation was monitored using a plasmin-sensitive chromogenic substrate.


RESULTS
Contrast media generally had an inhibitory effect at the plasminogen activation step; this effect was particularly noticeable with the ionic CM.


CONCLUSIONS
Contrast media influence plasminogen activation by SK and rt-PA in vitro. Ionic CM have a more pronounced inhibitory effect than the nonionic media. The ionic Gd-DTPA shows a less inhibitory effect than the ionic iodine-containing CM. However, they must be regarded separately because of the different chemical composition of the magnetic resonance imaging and x-ray CM.
Schilvold
A
A
Department of Radiology, Rikshospitalet, Oslo, Norway.
Bjørnsen
S
S
Ing
C
C
Brosstad
F
F
D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005340:Fibrinogen / Q000494:pharmacology; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000187:drug effects; D005682:Gadolinium / Q000008:administration & dosage / Q000494:pharmacology; D019786:Gadolinium DTPA; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D007485:Ioxaglic Acid / Q000008:administration & dosage / Q000494:pharmacology; D008794:Metrizoic Acid / Q000008:administration & dosage / Q000494:pharmacology; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D010958:Plasminogen / Q000187:drug effects*; D013300:Streptokinase / Q000494:pharmacology*; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000494:pharmacology
D003287:Contrast Media; D009942:Organometallic Compounds; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007472:Iohexol; C038192:iopromide; D004369:Pentetic Acid; C053571:iopentol; D005340:Fibrinogen; D010958:Plasminogen; D005682:Gadolinium; D008794:Metrizoic Acid; D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; C044834:iodixanol; D019786:Gadolinium DTPA; D007485:Ioxaglic Acid