Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV-induced disease in rhesus macaques.
We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen-stimulated PBMC, while in phase 3, virus was recovered from mitogen-stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy.
Laboratory of Viral Pathogenesis, Marion Merrell Dow Foundation, Kansas University Medical Center, Kansas City 66160-7424.
S V
SV
Joag
R J
RJ
Adams
L
L
Foresman
D
D
Galbreath
M C
MC
Zink
D M
DM
Pinson
H
H
McClure
O
O
Narayan
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002478:Cells, Cultured; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008212:Lymphocyte Depletion; D008253:Macaca mulatta; D011237:Predictive Value of Tests; D011379:Prognosis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*; D013997:Time Factors; D014779:Virus Replication