Simplified prothrombin time standardization.
An analysis of prothrombin time (PT) standardization methods is presented. The present recommended ratio method demonstrated complex calibration and wide therapeutic ranges. Standardization by coagulation activities resulted in different therapeutic ranges due to the different sensitivity of assays for the protein induced by vitamin K absence (Pivka) inhibitor. A new method--the modified coagulation activity method--applied a reference assay against which any PT assay can be calibrated by clotting times, and the results were expressed in coagulation activities by the reference assay. This method was preferable due to simple calibration, narrow therapeutic ranges and identical results by any PT assay.
Division of Hematology, Haukeland University Hospital, Bergen, Norway.
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Talstad
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Korsbrekke
D001777:Blood Coagulation / Q000187:drug effects; D002138:Calibration; D006801:Humans; D011517:Prothrombin Time; D011933:Reagent Kits, Diagnostic; D012015:Reference Standards; D012680:Sensitivity and Specificity; D014859:Warfarin / Q000008:administration & dosage / Q000494:pharmacology
D011933:Reagent Kits, Diagnostic; D014859:Warfarin