Laboratory evidence for the hormonal dependency of meningiomas.
Evidence for the hormonal dependency of meningiomas and of the value of various forms of endocrine therapy are described. Clinical features of the tumour are described. Laboratory evidence for the presence and activity of functional steroid receptors is described, and their characteristics are analysed. The effect of receptor antagonists on the growth of the tumour cells is indicated.
Olson
J J
JJ
Emory Clinic, Department of Neurosurgery, Atlanta, GA 30322.
D003131:Combined Modality Therapy; D005260:Female; D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000145:classification / Q000453:epidemiology / Q000628:therapy; D008579:Meningioma / Q000737:chemistry / Q000145:classification / Q000453:epidemiology / Q000628:therapy; D015735:Mifepristone / Q000627:therapeutic use; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local; D009376:Neoplasms, Hormone-Dependent / Q000737:chemistry / Q000145:classification / Q000453:epidemiology / Q000628:therapy; D011987:Receptors, Steroid / Q000032:analysis; D012737:Sex Factors; D013256:Steroids
D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D009363:Neoplasm Proteins; D011987:Receptors, Steroid; D013256:Steroids; D015735:Mifepristone