Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.
Previously, we showed that the M1 gene (encoding a viral core protein, mu 2, whose function is unknown) was associated with the efficiently myocarditic phenotype of a reovirus variant, 8B. Here, we have extended our genetic analysis of 8B and conducted genetic analyses of two other reovirus strains (T1L [serotype 1 strain Lang] and Abney). Our results demonstrate that multiple viral core proteins are determinants of reovirus-induced myocarditis. In contrast to our previous association of mu 2 with induction of myocarditis, this provides strong evidence that a core function achieved through the interaction of multiple core proteins is responsible for induction of the disease.
Sherry
B
B
Department of Microbiology, Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Blum
M A
MA
D000818:Animals; D000831:Animals, Newborn; D005814:Genes, Viral; D014644:Genetic Variation; D016679:Genome, Viral; D051379:Mice; D008815:Mice, Inbred Strains; D009205:Myocarditis / Q000821:virology*; D010641:Phenotype; D012087:Reoviridae / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D014758:Viral Core Proteins / Q000235:genetics*
D014758:Viral Core Proteins