Antigenicity and immunogenicity of experimental equine influenza ISCOM vaccines.
A comparison of the antigenicity and immunogenicity of ISCOM vaccines prepared from equine influenza viruses H3N8 and H7N7 was made with inactivated whole-virus vaccines containing equivalent amounts of virus haemagglutinin. ISCOMs stimulated superior antibody responses in terms of both amount and duration. As with conventional whole-virus vaccines, the levels of antibody to virus haemagglutinin induced by ISCOMs correlated with protection.
Animal Health Trust, Lanwades Park, Kennett, Suffolk, UK.
J A
JA
Mumford
D
D
Jessett
U
U
Dunleavy
J
J
Wood
D
D
Hannant
B
B
Sundquist
R F
RF
Cook
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000918:Antibody Specificity; D001831:Body Temperature; D004306:Dose-Response Relationship, Immunologic; D004591:Electrophoresis, Polyacrylamide Gel; D013007:Growth Hormone-Releasing Hormone / Q000276:immunology / Q000378:metabolism; D006385:Hemagglutination Inhibition Tests; D006389:Hemagglutinins, Viral / Q000276:immunology / Q000378:metabolism; D006462:Hemolytic Plaque Technique; D006734:Horse Diseases / Q000517:prevention & control; D006736:Horses; D016882:ISCOMs / Q000235:genetics / Q000276:immunology* / Q000648:ultrastructure; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D008854:Microscopy, Electron; D009976:Orthomyxoviridae Infections / Q000517:prevention & control / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000276:immunology; D017201:Virus Shedding
D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D016882:ISCOMs; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D013007:Growth Hormone-Releasing Hormone