The current epidemiology of hepatitis A infection in South Africa: implications for vaccination.
Testing stored sera from various categories of individuals has shown that among the Black population hepatitis A virus (HAV) infection is universal and most adult Black subjects are immune. Infection probably occurs early in life, consistent with the epidemiological pattern seen in the developing world. By contrast, seroprevalence of HAV infection in adult White subjects increases with age, reflecting an epidemiological pattern seen in the developed world. White subjects working in a virological laboratory and White medical students had comparatively low seroprevalences of HAV infection and could therefore represent groups at risk. Hepatitis A vaccine is likely to be available in South Africa in the near future and could be offered to these groups. Pre-vaccination immunity screening would be a cost-effective strategy.
National Institute for Virology, University of the Witwatersrand, Johannesburg, South Africa.
D J
DJ
Martin
N K
NK
Blackburn
S
S
Johnson
J M
JM
McAnerney
D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011897:Random Allocation; D012423:Rural Health; D013019:South Africa / Q000453:epidemiology; D014504:Urban Health
D006508:Hepatitis Antibodies; D007074:Immunoglobulin G