Consecutive glioblastoma and B cell non-Hodgkin's lymphoma in a young child with von Recklinghausen's Neurofibromatosis.
A young child with neurofibromatosis type 1 (NF1) is reported who developed two primary malignancies: a glioblastoma, followed 6 months later by an abdominal B cell non-Hodgkin's lymphoma. The child is now 4.5 years off treatment and disease free, but has developed progressive and severe psychomotor retardation as sequelae. The NF1 gene is known to act as a tumor suppressor gene. The possible mechanisms leading to the occurrence of a second primary tumor in this child are discussed.
Department of Paediatrics, University of Leuven, Belgium.
A
A
Uyttebroeck
E
E
Legius
P
P
Brock
W
W
Van de Cassey
P
P
Casaer
M
M
Casteels-Van Daele
D000008:Abdominal Neoplasms / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000150:complications*; D009456:Neurofibromatosis 1 / Q000150:complications*