Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding.
Dolle
R E
RE
Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
Singh
J
J
Rinker
J
J
Hoyer
D
D
Prasad
C V
CV
Graybill
T L
TL
Salvino
J M
JM
Helaszek
C T
CT
Miller
R E
RE
Ator
M A
MA
D000577:Amides / Q000737:chemistry*; D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D020170:Caspase 1; D003546:Cysteine Endopeptidases / Q000187:drug effects* / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D007659:Ketones / Q000378:metabolism / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009584:Nitrogen / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000577:Amides; D015853:Cysteine Proteinase Inhibitors; D007659:Ketones; D001224:Aspartic Acid; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D009584:Nitrogen