A versatile approach to the synthesis of combretastatins.
A new and versatile synthesis of combretastatins has been developed. Starting from commercially available materials, 2-phenyl-2-benzyl-1,3-dithianes were easily prepared and used as intermediates in the synthesis of several families of combretastatins. This approach facilitates the preparation of representative intermediates in a few steps, with or without an oxygenated function in the ethylenic residue. Many different analogues suitable for pharmacological evaluation can also be obtained from some of these intermediates.
Medarde
M
M
Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Salamanca, Spain.
Peláez-Lamamié de Clairac
R
R
López
J L
JL
San Feliciano
A
A
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D001632:Bibenzyls / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes
D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin