[Potentiation of digoxin by itraconazole].
The case is reported of a 71-year-old woman with clinical signs of digoxin intoxication, presumably developing as a result of the simultaneous use of digoxin for cardiac abnormalities and itraconazole for infection with Candida albicans. Five similar experiences have previously been reported in the literature. Itraconazole may induce a decreased elimination of digoxin, but the mechanism of interaction is still unknown. Comedication and renal function may perhaps contribute to the degree of interaction. When itraconazole is needed in a patient also using digoxin the blood level of the latter drug should be monitored; the daily dose of digoxin may have to be decreased to only one-quarter of the original. Nausea and anorexia may be mistaken for side effects of itraconazole and be overlooked as early signs of digoxin intoxication.
Meyboom
R H
RH
Stichting Landelijke Registratie Evaluatie Bijwerkingen LAREB, Tilburg.
de Jonge
K
K
Veentjer
H
H
Dekens-Konter
J A
JA
de Koning
G H
GH
D000368:Aged; D002179:Candidiasis, Cutaneous / Q000188:drug therapy*; D004077:Digoxin / Q000506:poisoning* / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology* / Q000627:therapeutic use
D017964:Itraconazole; D004077:Digoxin
Potentiëring van digoxine door itraconazol.