Effects of kappa-selenocarrageenan on membrane fluidity and ghost reseal ability of rat erythrocyte.
Effects of kappa-selenocarrageenan (kappa-SeC) on membrane fluidity and ghost reseal ability of rat erythrocyte were studied by measuring the fluorescence polarization and the NADH-cytochrome C oxido-reductase, respectively. After rats were given ig kappa-SeC 140 mg.kg-1.d-1 x 30 d, the fluorescence polarization was decreased in comparison with saline control group (P < 0.05). It suggested that kappa-SeC increased the membrane fluidity. The reseal ability of erythrocyte membrane (ghost) was also elevated after ig kappa-SeC 140 and 70 mg.kg-1.d-1 x 30 d (P < 0.05).
Li
D
D
Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China.
Han
Q
Q
Yang
X Y
XY
Rong
D M
DM
Lin
Z J
ZJ
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects; D002351:Carrageenan / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D005454:Fluorescence Polarization; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D009245:NADH Dehydrogenase / Q000378:metabolism; D016566:Organoselenium Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000889:Anti-Arrhythmia Agents; D016566:Organoselenium Compounds; C079969:kappa-selenocarrageenan; D002351:Carrageenan; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV