Paramyxovirus-like inclusions in an intradermal nevus from a healthy woman.
A healthy 52-year-old woman had an intradermal nevus removed from the right preauricular region. Histopathologic examination disclosed intranuclear and intracytoplasmic inclusions in many of the nevus cells. A basal-cell carcinoma, an additional intradermal nevus, and a fibrous papule of the nose were also excised, however, none of these lesions showed histologically similar inclusions within the lesions. Electron microscopic studies showed inclusions that were similar to those observed in cases of subacute sclerosing panencephalitis. Immunoperoxidase and polymerase chain reaction studies for the measles virus were performed, with negative results. The patient remains in good health 2 years after excision of the skin lesions.
Tschen
J A
JA
St. Joseph Hospital, Department of Pathology, Houston, TX 77022.
Tyring
S K
SK
Font
R L
RL
D002280:Basal Cell Carcinoma / Q000473:pathology; D002467:Cell Nucleus / Q000821:virology; D003593:Cytoplasm / Q000821:virology; D004428:Ear Neoplasms / Q000648:ultrastructure / Q000821:virology*; D005260:Female; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000821:virology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D018330:Nevus, Intradermal / Q000648:ultrastructure / Q000821:virology*; D009668:Nose Diseases / Q000473:pathology; D018108:Respirovirus / Q000302:isolation & purification*; D012878:Skin Neoplasms / Q000648:ultrastructure / Q000821:virology*; D013344:Subacute Sclerosing Panencephalitis / Q000821:virology