Pathobiology of intimal hyperplasia.
In the current vascular interventional environment, high restenosis rates have increased awareness of the significance of intimal hyperplasia, a chronic structural lesion that develops after vessel wall injury, and which can lead to luminal stenosis and occlusion. Intimal hyperplasia may be defined as the abnormal migration and proliferation of vascular smooth muscle cells with associated deposition of extracellular connective tissue matrix. The pathology of intimal hyperplasia is reviewed with particular attention to its physiology, pharmacology, cell biology and molecular biology.
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
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Davies
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Hagen
D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D006965:Hyperplasia; D007962:Leukocytes / Q000502:physiology; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D015398:Signal Transduction; D016211:Transforming Growth Factor alpha / Q000502:physiology; D017539:Tunica Intima / Q000473:pathology*
D010982:Platelet-Derived Growth Factor; D016211:Transforming Growth Factor alpha