Regional brain catecholamines and metabolites following THC, PCP and MK-801.
1. THC, PCP, and MK-801 increased DOPAC in rat olfactory tubercle and prefrontal cortex without affecting DA levels, suggesting increased DA release. 2. Effects on NE and MHPG were not evident. 3. These two classes of drugs can effect dopaminergic systems independently of noradrenergic systems.
Yale University Department of Psychiatry, New Haven, CT.
M B
MB
Bowers
J B
JB
Morton
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D013759:Dronabinol / Q000494:pharmacology*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009830:Olfactory Bulb / Q000187:drug effects / Q000378:metabolism; D010622:Phencyclidine / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D016291:Dizocilpine Maleate; D013759:Dronabinol; D010622:Phencyclidine; D004298:Dopamine; D009638:Norepinephrine