Diuretic and vasodilating actions of torasemide.
The pharmacological profile of torasemide was examined in experimental animals. In normotensive Wistar rats, torasemide produced less kaliuresis at doses that were equipotent with furosemide in terms of natriuresis. Torasemide but not furosemide exerted a significant diuretic action in rats treated with deoxycorticosterone acetate. Both torasemide and furosemide increased plasma renin activity and aldosterone concentration, but only torasemide significantly inhibited aldosterone-receptor binding in rat kidney. Torasemide also inhibited vasoconstriction induced by thromboxane A2 in isolated canine coronary artery.
Uchida
T
T
Green Cross Corporation, Central Research Laboratories, Pharmacology, Osaka, Japan.
Yamanaga
K
K
Kido
H
H
Ohtaki
Y
Y
Watanabe
M
M
D000450:Aldosterone / Q000097:blood / Q000378:metabolism; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide; D014665:Vasodilator Agents / Q000494:pharmacology*
D004232:Diuretics; D013449:Sulfonamides; D014665:Vasodilator Agents; D003900:Desoxycorticosterone; D000450:Aldosterone; D005665:Furosemide; D012083:Renin; D011188:Potassium; D000077786:Torsemide