A comparison of the endotoxin-retentive abilities of two '96-h' in-line intravenous filters.
The ability of two in-line intravenous filters, the Pall Intravenous Set Saver Filter ELD96 and the Codan I.V. S SET-P, to retain endotoxin released by Pseudomonas aeruginosa during filtration of amino-acid-based parenteral nutrition (PN) solutions was investigated. When challenged with 10(8) cells of P. aeruginosa during simulated clinical PN infusion, the Pall ELD96 was shown to be capable of providing an effluent free of detectable endotoxin (< 0.3125 EUE/ml). In contrast, the Codan I.V. S SET-P allowed significant amounts of endotoxin to pass through.
Sterile Product Unit, University Hospital of Wales, Cardiff, U.K.
C
C
Richards
P F
PF
Grassby
D002406:Catheterization, Peripheral / Q000379:methods*; D004340:Drug Contamination; D004731:Endotoxins / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D005374:Filtration / Q000379:methods*; D007262:Infusions, Intravenous; D008567:Membranes, Artificial; D011550:Pseudomonas aeruginosa
D004731:Endotoxins; D008567:Membranes, Artificial