[Effect of glutamate and combined with inosine monophosphate on gastric secretion].
Experiments on dogs with Pavlov pouch and gastric fistula demonstrate that monosodium glutamate (MSG) enriched with inosine monophosphate (IMP) potentiate pentagastrin-induced gastric secretion. The preparation (Chi-Mi) was introduced directly into the intestine through a fistula. When given alone in an equal quantity MSG produced the same effect. In per os administration Chi-Mi was more effective, probably due to a different response of the gustatory receptors to MSG and Chi-Mi. When the latter two were added to meat used as a food stimulus, Chi-Mi brought about more intensive gastric secretion in all its phases. In sham feeding Chi-Mi also intensified the secretion augmenting the reflex phase of gastric secretion when added to food substances. The findings may appear helpful in further search for medical application of glutamate and allied substances.
L S
LS
Vasilevskaia
M V
MV
Rymshina
G K
GK
Shlygin
D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005527:Food, Fortified; D005747:Gastric Fistula / Q000188:drug therapy / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007291:Inosine Monophosphate / Q000494:pharmacology* / Q000627:therapeutic use; D008954:Models, Biological; D010418:Pentagastrin / Q000494:pharmacology* / Q000627:therapeutic use; D012970:Sodium Glutamate / Q000494:pharmacology* / Q000627:therapeutic use
D007291:Inosine Monophosphate; D010418:Pentagastrin; D012970:Sodium Glutamate
Deĭstvie glutamata i ego sochetaniia s inozinmonofosfatom na zheludochnuiu sekretsiiu.