Penetrance and expressivity of the chromosome 9p melanoma susceptibility locus (MLM).
A susceptibility locus for familial melanoma has been localized to the short arm of chromosome 9. Penetrance of melanoma was estimated by calculating the Kaplan-Meier function and fitting a log normal hazard function in 124 gene carriers in three 9p-linked kindreds. The penetrance of the gene for melanoma was estimated to be 53% by age 80. Additionally, nevus counts, skin type, and sun exposure histories were gathered for 119 individuals in two kindreds. Gene carriers were found to have higher nevus counts and nevus densities than non-gene carriers. Among gene carriers, individuals with melanoma were found to have more sun exposure within each skin type than gene carriers without melanoma. These analyses suggest that the 9p melanoma susceptibility is related to total number of nevi and that it interacts with other genetic and environmental factors to produce melanoma.
Cannon-Albright
L A
LA
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
Meyer
L J
LJ
Goldgar
D E
DE
Lewis
C M
CM
McWhorter
W P
WP
Jost
M
M
Harrison
D
D
Anderson
D E
DE
Zone
J J
JJ
Skolnick
M H
MH
D000328:Adult; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D005260:Female; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000235:genetics