Procollagenase is reduced to inactive fragments upon activation in the presence of doxycycline.
Smith
G N
GN
Arthritis Center, Indiana University School of Medicine, Indianapolis 46202.
Brandt
K D
KD
Hasty
K A
KA
D017364:Collagenases / Q000737:chemistry / Q000378:metabolism*; D004318:Doxycycline / Q000494:pharmacology*; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D020784:Matrix Metalloproteinase 8; D009504:Neutrophils / Q000201:enzymology; D010446:Peptide Fragments / Q000302:isolation & purification / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism*
D004792:Enzyme Precursors; D010446:Peptide Fragments; D011994:Recombinant Proteins; D014357:Trypsin; D017364:Collagenases; C022440:procollagenase; D020784:Matrix Metalloproteinase 8; D004318:Doxycycline