Reversible functional asplenia. Autoimmune hemolytic anemia with thrombocytopenia in chronic lymphocytic leukemia.
An enlarged spleen failed to accumulate Tc-99m-labeled phytate, but it showed normal perfusion and uptake of labeled and heat-denatured red blood cells. A blood cell count demonstrated moderately low hemoglobin and hematocrit levels and a markedly low platelet count, and results of direct Coombs' and antiplatelet-antibody (IgG) tests were positive. Steroid therapy resulted in normal splenic function. This case demonstrates reversible functional asplenia caused by reticuloendothelial dysfunction secondary to pure splenic chronic lymphocytic leukemia.
Hirano
T
T
Department of Nuclear Medicine, Gunma University, School of Medicine, Japan.
Tomiyoshi
K
K
Take
H
H
Watanabe
N
N
Oriuchi
N
N
Inoue
T
T
Naruse
M
M
Endo
K
K
D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000209:etiology*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D017254:Leukemic Infiltration / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011239:Prednisolone / Q000627:therapeutic use; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013154:Spleen / Q000000981:diagnostic imaging* / Q000473:pathology; D013163:Splenomegaly / Q000000981:diagnostic imaging* / Q000209:etiology; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology*
D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid; D011239:Prednisolone; D013670:Sodium Pertechnetate Tc 99m