The role of antigen in maintaining T cell memory.
Evidence is summarized supporting the view that persisting antigen is key to the maintenance of immunological memory by helper and cytotoxic T cells against viruses. If these findings are generalised, they are obviously relevant to vaccine strategies.
Institute of Experimental Immunology, University Hospital, Zürich, Switzerland.
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Zinkernagel
D000818:Animals; D000941:Antigens / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014611:Vaccination; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
D000941:Antigens; D000956:Antigens, Viral