Tourette's syndrome associated with restless legs syndrome and akathisia in a family.
A family with coincidence of a restless leg syndrome (RLS) in the mother and a Gilles de la Tourette syndrome (GTS) in the son who also shows increased vulnerability to neuroleptic induced akathisia (NIA) is presented. Since these diseases show parallels from a genetic, pathogenetic and clinical point of view, the familiar coincidence is discussed under these aspects with respect to suggested disturbances of the dopamine and the opiate systems in RLS, GTS, and NIA.
Department of Psychiatry, Klinikum Innenstadt, University of Munich, Germany.
N
N
Müller
U
U
Voderholzer
G
G
Kurtz
A
A
Straube
D000293:Adolescent; D000328:Adult; D017109:Akathisia, Drug-Induced / Q000235:genetics*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008429:Maternal Welfare; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000235:genetics*; D012890:Sleep; D005879:Tourette Syndrome / Q000188:drug therapy / Q000235:genetics*
D014150:Antipsychotic Agents; D004298:Dopamine