Electrophysiological effects of cholecystokinin on neurons in rat substantia nigra pars reticulata.
The electrophysiological effects of carboxyterminal fragments of cholecystokinin (CCK) on neurons in the dorsal substantia nigra pars reticulata (SNr) were evaluated in anesthetized rats. Microiontophoretic administration of sulfated CCK octapeptide (CCK-8S, agonist for CCK-A and CCK-B receptors) and the selective CCK-B receptor agonists, CCK-4 and unsulfated CCK-8, inhibited the firing rates of a subpopulation of SNr neurons. This effect appears to be mediated by CCK-B receptors.
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48202.
J
J
Zhang
A S
AS
Freeman
D000818:Animals; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004594:Electrophysiology; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000819:agonists / Q000037:antagonists & inhibitors; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D010446:Peptide Fragments; D011949:Receptors, Cholecystokinin; D005680:gamma-Aminobutyric Acid; D002766:Cholecystokinin