Effect of 4 kHz tone exposure on the guinea pig inner ear: relation in the change of cochlear microphonics, action potential, electrochemical potential and K+ ion concentration induced by noise exposure.
Using 110 male albino guinea pigs, and applying electrophysiological methods, we investigated the effects of 4 kHz tone at moderate sound pressure level on the inner ear at different exposure times (6, 12, 24 and 48 h). Longer than 12 h exposure to 4 kHz tone had a considerable effect on the hearing, inducing a decrease in the maximum output voltage of cochlear microphonics and an increase in the K+ concentration in the endolymph.
Department of Hygiene, Asahikawa Medical College, Hokkaido, Japan.
T
T
Sugisawa
R
R
Nemoto
N
N
Inada
K
K
Yamamura
A
A
Ishida
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D007758:Ear, Inner / Q000502:physiology*; D004563:Electrochemistry; D004710:Endolymph / Q000378:metabolism; D006168:Guinea Pigs; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D009622:Noise; D011188:Potassium / Q000378:metabolism*; D011930:Reaction Time / Q000502:physiology; D013016:Sound; D013997:Time Factors; D014725:Vestibular Nerve / Q000502:physiology
D011188:Potassium