Pro- and anti-inflammatory cytokines: interactions with vascular endothelium.
Cytokines elicit the expression of distinct sets of functions in endothelium. IL-1 activates endothelium in a prothrombotic-proinflammatory sense. The characteristics and significance of IL-1 inducible genes cloned from endothelial cells is discussed.
Istituto di Richerche Farmacologiche Mario Negri, Milano, Italy.
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M
Introna
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F
Colotta
S
S
Sozzani
E
E
Dejana
A
A
Mantovani
D016207:Cytokines / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D014657:Vasculitis / Q000209:etiology*
D016207:Cytokines; D007375:Interleukin-1; D017472:Receptors, Interleukin-1