Effects of subinhibitory concentrations of seven macrolides and four fluoroquinolones on adhesion of Staphylococcus aureus to human mucosal cells.
Reaction of bacterial adhesins with complementary receptors on the surfaces of mucosal respiratory, gastrointestinal and genitourinary cells leads to bacterial adhesion to the human body. This is the first step in the sequence of events leading to infection. It has been observed that subinhibitory concentrations (sub-MICs) of some antibiotics are able to reduce bacterial adhesion. The pharmacokinetic curves of antibiotics show that these sub-MICs are present in tissues during a typical course of therapy. This study investigated the ability of sub-MICs of seven macrolides and four fluoroquinolones to reduce adhesiveness of Staphylococcus aureus to human buccal cells. The literature generally reports data for only one antibiotic at a time. To obtain an overall view of the findings of eleven antibiotics together, the data have been normalized according to the molecular weight of each antibiotic and the dose-effect curves determined.
Department of Pharmacology, School of Medicine, University of Milan, Italy.
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Braga
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D002610:Cheek; D004848:Epithelium / Q000382:microbiology; D024841:Fluoroquinolones; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009061:Mouth Mucosa / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000502:physiology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides