Body composition assessed by bioelectrical impedance analysis (BIA) and the correlation with plasma insulin-like growth factor I (IGF-I) in normal Japanese subjects and patients with acromegaly and GH deficiency.
Body composition was assessed by bioelectrical impedance analysis (BIA) in 100 Japanese normal adults, 9 patients with acromegaly and 11 patients with growth hormone (GH) deficiency. Body weight (BW) was greater in normal males than in normal females. Percent body fat (BF/BW) was greater in females than in males and was increased with age in both sexes. Percent total body water (TBW/BW) was less in females than in males. Although percent extracellular water (ECW/BW) was not different between both sexes, the ECW/TBW ratio was greater in females than in males. Percent body cell mass (BCM/BW) was lower in females than in males. The patients with acromegaly had a lower percent BF but a higher percent TBW, percent ECW and ECW/TBW ratio than normal subjects, while the patients with GH deficiency had a higher percent BF and ECW/TBW ratio, but lower percent TBW. Percent body cell mass (BCM/BW) was higher in acromegaly and lower in GH deficiency than in normals. There was a negative correlation (r = -0.62) between plasma IGF-I levels and percent BF, whereas a positive correlation (r = 0.51) was found between the plasma IGF-I level and percent BCM. It is suggested, therefore, that body composition is affected by sex and age in normals, and by GH secretion in patients with pituitary dysfunction. Plasma IGF-I levels may be one of the factors responsible for alterations in body composition.
Department of Medicine, Shimane Medical University, Izumo, Japan.
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Hu
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Yamamoto
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Sohmiya
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Abe
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Murakami
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Kato
D000172:Acromegaly / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001823:Body Composition / Q000502:physiology*; D017097:Electric Impedance; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007564:Japan; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D017678:Sex Distribution
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone