[Milrinone decreases the positive inotropic response of heart muscle to izadrin].
The interaction of the cAMP-phosphodiesterase inhibitor milrinone and the beta-adrenoceptor agonist isoproterenol was studied on guinea-pig isolated hearts. Milrinone, (10 microns) caused a positive inotropic response which differed from that of isoproterenol (7 nM) and decreased cardiac inotropic responses to the subsequent administration of isadrin despite a significant great rise in cAMP. The interaction of the drugs is assumed to be associated with the milrinone-induced increase in cGMP which is able to restrict myocardial cAMP-activated processes.
Bardamova
I B
IB
Afanas'ev
S A
SA
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D020105:Milrinone; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D011728:Pyridones / Q000494:pharmacology*
D002316:Cardiotonic Agents; D011728:Pyridones; D000242:Cyclic AMP; D020105:Milrinone; D007545:Isoproterenol
Milrinon snizhaet polozhitel'nyĭ inotropnyĭ otvet serdechnoĭ myshtsy na izadrin.