Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine.
Systemic administration of lysine to mice injected with indium-111-labelled Fab fragment of a monoclonal antibody has been shown to reduce renal uptake/retention of the radiometal. This treatment should be applicable to clinical immunoscintigraphy and radioimmunotherapy with radiometal-labelled antibody fragments.
Cancer Research Laboratories, University of Nottingham, UK.
M V
MV
Pimm
S J
SJ
Gribben
D000818:Animals; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D007684:Kidney Tubules / Q000000981:diagnostic imaging*; D008239:Lysine / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D016719:Radioimmunodetection; D016499:Radioimmunotherapy; D014018:Tissue Distribution
D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D008239:Lysine