Shigellosis in Calcutta during 1990-1992: antibiotic susceptibility pattern and clinical features.
Of 230 cases of bloody diarrhoea studied, 100 (43.5%) were positive for Shigellae by stool culture, of which Shigella dysenteriae type 1 was isolated from 56 cases, S. flexneri from 35, S. boydii from 5 and S. sonnei from 4. The major clinical manifestations of the patients infected with Shigella spp. were abdominal pain, anorexia, vomiting, tenesmus, and fever. Fever of above 100.5 degrees F and frequency of stool of more than 15 per day were noticed more among cases infected with S. dysenteriae type 1 and S. flexneri. Vomiting was more frequently observed in cases infected with S. sonnei or S. boydii (44.4%) as compared to those infected with S. dysenteriae type 1 (10.7%) and S. flexneri (8.6%). All Shigella isolates were uniformly susceptible to norfloxacin and ciprofloxacin but were resistant to streptomycin. S. dysenteriae type 1 isolates were susceptible to nalidixic acid (69.6%), ampicillin (5.4%), TMP-SMX (12.5%), furazolidone (98.2%) and gentamycin (80.4%), whereas all other Shigella isolates (S. flexneri, S. boydii, and S. sonnei) were uniformly susceptible to nalidixic acid, > 94% susceptible to furazolidone, and only moderately susceptible to ampicillin (28.6% to 55.5%) and TMP-SMX (22.2% to 48.6%).
Bhattacharya
M K
MK
National Institute of Cholera & Enteric Diseases (NICED), Beliaghata, Calcutta, India.
Bhattacharya
S K
SK
Paul
M
M
Dutta
D
D
Dutta
P
P
Kole
H
H
De
D
D
Ghosh
A R
AR
Das
P
P
Nair
G B
GB
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004405:Dysentery, Bacillary / Q000150:complications / Q000382:microbiology*; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D012760:Shigella / Q000187:drug effects / Q000302:isolation & purification*; D013045:Species Specificity
D000900:Anti-Bacterial Agents