[Inhibitory effects of esculentoside A on mouse macrophages and antibody production].
Esculentoside A (EsA) is a kind of saponin isolated from Phytolacca esculenta Van Houtte. It was shown to significantly inhibit phagocytic activity, intracellular and extracellular production of interleukin-1 by thioglycollate primed murine peritoneal macrophages in vitro at the concentration 0.01-1.0 mumol.L-1. In vivo experiments showed that EsA 2.5-5 mg.kg-1 markedly decreased serum hemolysin concentration in sensitized mice challenged with sheep red blood cells. Inhibition of antibody production by B lymphocytes, phagocytosis and the production of inflammatory mediators by macrophages may partially explain the wide and strong anti-inflammatory effect of EsA.
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai.
D W
DW
Ju
Q Y
QY
Zheng
H B
HB
Wang
X J
XJ
Guan
J
J
Fang
Y H
YH
Yi
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000917:Antibody Formation; D006460:Hemolysin Proteins / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010587:Phagocytosis / Q000187:drug effects*; D012503:Saponins / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006460:Hemolysin Proteins; D007375:Interleukin-1; D012503:Saponins; C076297:esculentoside A; D009828:Oleanolic Acid