Genetic control of the human V beta 13.2 T cell repertoire: importance of allelic variation outside the coding regions of the TCRBV13S2 gene.
In humans, the T cell repertoire is influenced by HLA, T cell receptor null alleles and antigen. Here, we describe a novel mechanism, independent of superantigen or T cell receptor structure which influences the T cell repertoire in a V beta-dependent manner. We have identified a biallelic locus, the TCRBV13S2 T cell receptor gene, where allelic differences predominate in the non-coding regions including transitions, transversions and frameshift deletions. The expressed protein is non-polymorphic at this locus. The TCRBV13S2 genotype profoundly influences the circulating levels of V beta 13.2 CD4 T cells but does not affect T cell receptor expression or function.
Department of Biological Sciences, University of Manchester.
R A
RA
Kay
N
N
Snowden
A H
AH
Hajeer
A W
AW
Boylston
W E
WE
Ollier
D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis / Q000235:genetics* / Q000502:physiology
D016693:Receptors, Antigen, T-Cell, alpha-beta