Vascularization of human endometrium. Uterine blood flow in healthy condition and in primary dysmenorrhoea.
The anatomy of the human uterine vascular tree changes repeatedly with the variations in hormonal state during each menstrual cycle, with progressive differentiation of arterioles up to the premenstrual state. Hormonal factors also influence the innervation of uterine arteries, both cholinergic, adrenergic and peptidergic, and regulate the spontaneous contractile activity of the smooth muscle of vessel walls as well as the motor responses of these tissues to different vasoactive substances. The smaller branches of uterine arteries, i.e., the resistance arteries appear to be of particular importance in the regulation of uterine blood flow, since they are most densely innervated. Furthermore, the most effective uterine vasoconstrictors in vitro, vasopressin, endothelin, oxytocin and noradrenaline have a more pronounced effect on these vessels than on the main branches of the uterine artery. Vascular compression may also result from changes in the myometrial activity. A hormonal disturbance may cause dysfunctional bleeding by changing vessel growth as well as the uterine smooth muscle activity of both vessels and myometrium. An example of the latter phenomenon is primary dysmenorrhoea, women with this condition having an increased secretion of vasopressin. By an action on type V1 vasopressin receptors of the uterus, this peptide causes myometrial hyperactivity and vasoconstriction, with resultant uterine ischemia and pain. Further support for a pathophysiological role of vasopressin and also of oxytocin in dysmenorrhoea is the therapeutic effect of a competitive type V1 vasopressin and oxytocin receptor antagonist in the condition.
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
M
M
Akerlund
D001158:Arteries / Q000294:innervation; D004412:Dysmenorrhea / Q000503:physiopathology*; D004717:Endometrium / Q000098:blood supply*; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D011374:Progesterone / Q000502:physiology; D014599:Uterus / Q000098:blood supply*; D014666:Vasomotor System / Q000187:drug effects
D004967:Estrogens; D011374:Progesterone