Chronic hypoxia affects peripheral and central vasoactive intestinal peptide-like immunoreactivity in the rat.
The influence of long-term hypoxia on vasoactive intestinal peptide-like immunoreactivity (VIP-LI) in discrete brain areas and peripheral structures was assessed by RIA. Rats were exposed to normobaric hypoxia (10% O2-90% N2) for 14 days. VIP-LI was significantly increased in carotid bodies of hypoxic animals (204% vs. normoxic animals). On the other hand, VIP-LI was decreased in the anterior pituitary (-68%), suprachiasmatic nuclei (-29%) and periventricular nuclei (-26%). No significant variation in VIP-LI was observed in other peripheral structures and discrete brain area studied. These results suggest that long-term hypoxia induces alterations in VIP systems implicated in chemoreception, biological rhythms and neuroendocrine functions.
Département de Médecine Expérimentale, INSERM U 52, CNRS URA 1195, Université Claude Bernard, Lyon, France.
L
L
Poncet
L
L
Denoroy
Y
Y
Dalmaz
J M
JM
Péquignot
M
M
Jouvet
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002344:Carotid Body / Q000378:metabolism*; D002908:Chronic Disease; D005724:Ganglia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014660:Vasoactive Intestinal Peptide / Q000032:analysis / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide