Permeability of biological and synthetic molecules through dentine.
The diffusion through dentine by a number of biological and synthetic molecules, including resins and dyes, is reported. In vitro measurements were derived by experiments with a modified 'split-chamber device'. Diffusion was found to be indirectly proportional to dentine thickness for all molecules. Permeability of water-soluble molecules and ethanol-soluble molecules was proportional to the molecular weights, except for fluorescein, hydrogen peroxide (H2O2) and urethane dimethacrylate. The resin components tested are not soluble enough in an aqueous medium to diffuse through 0.5 mm dentine at sufficient concentrations to cause cytotoxicity to pulpal cells.
Hanks
C T
CT
University of Michigan School of Dentistry, Ann Arbor 48109-1078.
Wataha
J C
JC
Parsell
R R
RR
Strawn
S E
SE
Fat
J C
JC
D001798:Blood Proteins / Q000737:chemistry; D003806:Dentin Permeability; D004058:Diffusion; D015194:Diffusion Chambers, Culture; D000431:Ethanol; D005452:Fluoresceins / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D008970:Molecular Weight; D010636:Phenols / Q000737:chemistry; D012117:Resins, Synthetic / Q000737:chemistry; D012995:Solubility; D013053:Spectrophotometry; D014867:Water
D001798:Blood Proteins; D005452:Fluoresceins; D010636:Phenols; D012117:Resins, Synthetic; D014867:Water; D000431:Ethanol; D006861:Hydrogen Peroxide