Memory systems in normal and pathological aging.
Normal memory depends on a number of interdependent systems whose specialized contributions are dissociable at both cognitive and neurobiological levels of analysis. Guided by this multiple systems view of memory, this review provides a selective survey of recent studies on cognitive and neurobiological aging. Taken together, the results suggest that memory decline in human aging partly reflects a compromise of executive memory processes supported by frontal lobe regions of the brain, combined with a deterioration of explicit memory capacities supported by the hippocampal system. Defining how deficits in multiple memory systems interact to account for cognitive aging remains a significant challenge.
Rapp
P R
PR
State University of New York at Stony Brook.
Heindel
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WC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D005625:Frontal Lobe / Q000503:physiopathology; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D009483:Neuropsychological Tests; D012016:Reference Values