Effectiveness of high-dose intravenous gamma globulin therapy in acquired von Willebrand's disease.
An 82-year-old patient with acquired von Willebrand's disease in association with a non-Hodgkin's lymphoma and a benign IgG-lambda monoclonal paraproteinemia is described with severe recurring nasopharyngeal bleedings, who responded poorly to desmopressin (DDAVP) and factor VIII/von Willebrand factor concentrates but was successfully treated with high-dose e intravenous gamma-globulin therapy.
Department of Haematology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
P J
PJ
van Genderen
J J
JJ
Michiels
J J
JJ
Bakker
M B
MB
van 't Veer
D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy*; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D007146:Immunoglobulin lambda-Chains; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D016393:Lymphoma, B-Cell / Q000150:complications; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications; D014842:von Willebrand Diseases / Q000209:etiology / Q000628:therapy*; D014841:von Willebrand Factor / Q000276:immunology
D001323:Autoantibodies; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D016756:Immunoglobulins, Intravenous; D014841:von Willebrand Factor; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin