Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations.
The effects of garlic (Allium sativum L., Liliaceae) dialysate were studied on arrhythmias induced in anaesthetized dogs and on isolated left rat atria. Garlic dialysate suppressed premature ventricular contractions (PVC) and ventricular tachycardia (VT) in ouabain-intoxicated dogs as well as the ectopic rhythms induced by isoprenaline (10(-6) M) and aconitine (10(-8) M) on electrically driven left rat atria. The effective refractory period (ERP) and the sinus node recovery time (SNRT) of isolated rat atria were prolonged in a dose-dependent manner by the administration of this extract. Garlic dialysate decreased the positive inotropic and chronotropic effects of isoprenaline in a concentration-dependent manner. These last effects were increased by propranolol. The results suggest that garlic dialysate has a significant antiarrhythmic effect in both ventricular and supraventricular arrhythmias.
Martín
N
N
Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Bardisa
L
L
Pantoja
C
C
Vargas
M
M
Quezada
P
P
Valenzuela
J
J
D000157:Aconitine / Q000633:toxicity; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D003956:Dialysis; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D005737:Garlic; D006325:Heart Atria / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010042:Ouabain / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology
D010936:Plant Extracts; D010042:Ouabain; D011433:Propranolol; D007545:Isoproterenol; D000157:Aconitine