[The level of spontaneous genomic mutations in the somatic cells of human embryos].
The study of the level of spontaneous genomic mutations in some human medical abortuses has demonstrated the intertissular variability in frequencies of polyploidies and endoreduplications in somatic cells of embryos. In fibroblasts they are encountered more frequently than in lymphoid cells. In the process of culturing in vitro the number of polypoidies and endoreduplications increases with passages. The frequency of polyploidies is significantly higher in human embryos than in pregnant women. There was no difference in the frequency of endoduplications between lymphocytes of pregnant women and embryos.
Lozyns'ka
M R
MR
Hnateĭko
O Z
OZ
Havryliuk
Iu I
IuI
D002478:Cells, Cultured; D004622:Embryo, Mammalian / Q000648:ultrastructure*; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D015894:Genome, Human; D005865:Gestational Age; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008677:Metaphase; D009154:Mutation / Q000235:genetics*; D011123:Polyploidy; D011247:Pregnancy; D011261:Pregnancy Trimester, First
Riven' spontannykh henomnykh mutatsiĭ v somatychnykh klitynakh embrioniv liudyny.