CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders.
To assess the diagnostic value of measuring CA-125 levels in peritoneal fluid from women with nonmalignant gynecologic disorders, we determined CA-125 levels in peritoneal fluid and in serum collected simultaneously from 46 women undergoing gynecologic surgery. Patients with benign ovarian disease, non-ovarian gynecologic pathology and severe endometriosis had, on average, higher CA-125 levels in peritoneal fluid than did patients with a normal pelvis and those with mild endometriosis. There was no obvious correlation between peritoneal fluid and serum levels of CA-125. Our data show that (1) measurement of serum CA-125 levels is not useful for distinguishing between different benign gynecologic disorders, and (2) levels of CA-125 in peritoneal fluid in benign gynecologic disorders are comparable to the reported lower range of levels observed in women with intraperitoneal malignancies.
Ismail
M A
MA
Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637.
Rotmensch
J
J
Mercer
L J
LJ
Block
B S
BS
Salti
G I
GI
Holt
J A
JA
D000359:Aftercare; D001202:Ascitic Fluid / Q000737:chemistry*; D018394:CA-125 Antigen / Q000032:analysis*; D015986:Confounding Factors, Epidemiologic; D003937:Diagnosis, Differential; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D012680:Sensitivity and Specificity
D018394:CA-125 Antigen