Fatty acids, hyperinsulinemia, and insulin resistance: which comes first?
The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue is halted in prevalent conditions with systemic insulin resistance. The nature and cause of this perturbation are unknown, but steroid hormones may be involved. The consequence is the creation or amplification of insulin resistance in muscle and liver.
Björntorp
P
P
Department of Heart and Lung Diseases, University of Göteborg, Sweden.
D000273:Adipose Tissue / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010084:Oxidation-Reduction
D005230:Fatty Acids, Nonesterified