[Role of lipid peroxidation, prostanoids and cyclic nucleotides in the individual resistance of animals to exogenous catecholamines].
The role of the lipid peroxidation, power of the antioxidants, peculiarities of synthesis of some prostanoids and cyclic nucleotides in determination of the rabbit individual sensitivity to exogenous catecholamines was studied. Some peculiarities of the initial state of homeostasis both of the survived and lost rabbits are demonstrated. It is determined that the low stability to izadrine's administration of the lost rabbits may be associated with the higher basal activity of the lipid peroxidation and the smaller antioxidative power. The peculiarities of the arachidonic acid's metabolism, which are associated with this, modulate the activity of the cyclic nucleotide enzymes. The latter may mobilize the cAMP-dependent mechanisms of the intracellular hormone signal transduction.
Zynkovych
Y Y
YY
Iakubenko
E D
ED
Ziablitsev
S V
SV
Khrypachenko
Y A
YA
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001481:Basal Metabolism; D002395:Catecholamines / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D009712:Nucleotides, Cyclic / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology*; D011817:Rabbits
D000975:Antioxidants; D002395:Catecholamines; D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D007545:Isoproterenol
Rol' perekysnoho okyslenyia lypydov, prostanoydov i tsiklycheskykh nukleotydov v yndyvydual'noĭ ustoĭchyvosty zhyvotnykh k ékzohennym katekholamynam.