Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D.
The structure of a unique polythiazole-containing cyclic peptide antibiotic, amythiamicin D, was elucidated by chemical degradations and NMR spectral analyses. Acid hydrolysis of amythiamicin D gave one mole of glycine and three new amino acids. Structures of N-acetyl-O-methyl derivatives of these new amino acids were determined by NMR and UV spectral analyses. Connectivities of these amino acids were determined by HMBC experiments.
Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan.
K
K
Shimanaka
Y
Y
Takahashi
H
H
Iinuma
H
H
Naganawa
T
T
Takeuchi
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006851:Hydrochloric Acid; D006868:Hydrolysis; D047028:Macrocyclic Compounds; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013844:Thiazoles
D000900:Anti-Bacterial Agents; D047028:Macrocyclic Compounds; D013844:Thiazoles; C088501:amythiamicin D; D006851:Hydrochloric Acid