Metabolic changes following cortical contusion: relationships to edema and morphological changes.
Rats with contusion injury to the right cortex exhibited significant formation of edema 6 and 24 hours after injury which resolved by 8 days and was replaced by cavitation necrosis. The contusions produced hyperglycolysis and ischemia in the impacted cortical tissue and underlying hippocampus immediately through 30 minutes post-injury. Glucose utilization was depressed throughout the contused cortex and in ipsilateral subcortical regions, as was blood flow, at chronic (1 and 10 days) periods after injury.
Sutton
R L
RL
Division of Neurosurgery, University of New Mexico, Albuquerque.
Hovda
D A
DA
Adelson
P D
PD
Benzel
E C
EC
Becker
D P
DP
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001924:Brain Concussion / Q000473:pathology / Q000503:physiopathology*; D001929:Brain Edema / Q000473:pathology / Q000503:physiopathology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000502:physiology
D001786:Blood Glucose