Study of the effect of a Chinese medical preparation, hokoei-to, on the rat ovary.
Female rats were given Hokoei-to orally to investigate its effects on hormones. Progesterone and estradiol levels fell markedly in ovariectomized young rats. Administration of Hokoei-to for 25 d produced increased levels of hormones in these rats. A similar effect was found in parous rats, demonstrating replacement of the lost female hormones after Hokoei-to administration.
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
T
T
Yokozawa
A
A
Tsuji
H
H
Maeda
M
M
Hattori
D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; C090387:Hokoei-to; D011374:Progesterone; D004958:Estradiol