Successful treatment of recurrent thrombotic thrombocytopenic purpura with plasmapheresis and vincristine.
An adolescent girl with severe thrombotic thrombocytopenic purpura (TTP) remained in a critical condition after 3 weeks of combined treatment with antiplatelet drugs, plasma infusions and plasma exchange. The introduction of vincristine resulted in gradual improvement and eventual complete remission which lasted for 2 years. When she relapsed, immediate improvement was observed with the combined treatment of plasmapheresis and vincristine. She has now been in complete remission again for 10 months. It is suggested that plasmapheresis plus vincristine should be used as the initial treatment for children with TTP.
Department of Paediatrics, University Hospital, Gasthuisberg, Leuven, Belgium.
S
S
Van Gool
P
P
Brock
P
P
Van Laer
R
R
Van Damme-Lombaerts
W
W
Proesmans
M
M
Casteels-Van Daele
D000293:Adolescent; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D010956:Plasmapheresis; D010976:Platelet Count; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D012008:Recurrence; D014750:Vincristine / Q000627:therapeutic use*
D014750:Vincristine