Localization of the human gene for Src-related protein tyrosine kinase LYN to chromosome 8q11-12: a lymphoid signaling cluster?
A member of the Src family of protein tyrosine kinases, Lyn is involved in the signaling pathways for cytokine or immunoglobulin-stimulated blood cells. Lyn is especially prominent in B-cell function. We have fine mapped LYN to chromosome 8q11-12 by fluorescence in situ hybridization. Of note, the gene for the pre-B cell growth factor, interleukin 7 (IL-7), has been mapped to 8q12-13. We show that IL-7 increases the protein tyrosine kinase activity of Lyn in the Daudi B-cell line. A third gene, HYRC, whose product may be involved in immunoglobulin rearrangement, has recently been localized to 8q11. We postulate that a lymphoid signaling region exists at 8q11-13.
Department of Pediatrics, University of Pittsburgh School of Medicine, PA.
S J
SJ
Corey
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DN
Shapiro
D001483:Base Sequence; D002898:Chromosomes, Human, Pair 8; D017931:DNA Primers / Q000737:chemistry; D005796:Genes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015851:Interleukin-7 / Q000494:pharmacology; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D019061:src-Family Kinases
D017931:DNA Primers; D015851:Interleukin-7; D011505:Protein-Tyrosine Kinases; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases