Frequency, pathogenicity and microbiologic outcome of non-Candida albicans candiduria.
A retrospective review of urine cultures obtained from patients at the University of Illinois Hospital revealed that the frequency of isolation of non-albicans Candida species increased significantly from 1990 to 1991 (p = 0.0003), while the frequency of isolation of Candida albicans species decreased significantly (p = 0.0006). Patients with urine cultures positive for non-albicans Candida species of Torulopsis glabrata during 1991 were identified for review. Sixty-seven patients were eligible for evaluation. Non-albicans candiduria developed in an average of 12 days. Identical fungal species were isolated from the blood following a positive urine culture in only two patients. Twenty patients were treated; candiduria persisted in 9 (45%), while resolution occurred in 11 (55%). The remaining 47 patients were not treated. Non-albicans candiduria persisted in 30 (64%) of these patients and resolved in 15 (32%); in the remaining two patients (4%) the microbiologic outcome was undetermined. The difference in microbiologic outcomes between treated and untreated patients was not significant using the Chi-square test (p = 0.170). Non-albicans candiduria developed rapidly, frequently persisted whether treated or untreated, and rarely progressed to candidemia.
Occhipinti
D J
DJ
Department of Medicine, College of Pharmacy, University of Illinois at Chicago 60612.
Gubbins
P O
PO
Schreckenberger
P
P
Danziger
L H
LH
D000283:Administration, Intravesical; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002175:Candida / Q000302:isolation & purification* / Q000472:pathogenicity; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy / Q000652:urine; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014556:Urine / Q000382:microbiology*
D000900:Anti-Bacterial Agents