Patch-clamp analysis of hypoglycemia-induced inhibition of synaptic transmission in the rat dorsolateral septal nucleus.
The role of glucose in neuronal transmission was examined in the rat dorsolateral septal nucleus (DLSN) by using 'slice-patch' techniques. Removal of glucose from the oxygenated Krebs solution produced an outward current associated with an increased K+ conductance. The glucose-depletion depressed the excitatory postsynaptic current (EPSC), the inhibitory postsynaptic current (IPSC) and the late hyperpolarizing current (LHC) produced by stimulation of the fimbria/fornix pathway. It is hypothesized that glucose regulates neurotransmission in the rat DLSN by modulating the release of transmitters from presynaptic nerve terminals.
Tsurusaki
M
M
Department of Physiology, Kurume University School of Medicine, Japan.
Akasu
T
T
Shoji
S
S
D000818:Animals; D007003:Hypoglycemia / Q000503:physiopathology*; D008297:Male; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D012686:Septal Nuclei / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology*