[Anatomopathologic changes in the testis following prolonged treatment with LHRH agonists. Experimental study in rats].
Presentation of a study conducted on 20 male Wistar rats treated for 3 months with Leuprolide (LHRH agonist). Analysis of pathophysiological testicular changes resulting from the treatment and extent of recovery at 3 months of therapy discontinuation, relating those changes to testosterone plasma levels in peripheral blood. Serum testosterone fell to 1.17 +/- 0.30 ng/ml in the treated group, shifting to figures overlapping with normal values within 3 months of discontinuing treatment. Such decreased testosterone levels translate into significant testicular histological damage. Three months after interruption of treatment there is nearly complete recovery of such damage, with just around 10% tubules without spermatozoa, with unchanged germinal line. We conclude that the marked suppression in testosterone levels caused by LHRH agonists translates into a significant degeneration of the seminiferous tubule, which appears to be reversible 3 months after treatment discontinuation.
Servicio de Investigaciones Biotecnológicas, Hospital General Universitario de Valencia.
V
V
Gonzalvo
M A
MA
Calvo
P
P
Navalón
D
D
Cejalvo
F J
FJ
Ramada
V
V
Sabater
J E
JE
Blasco
C
C
Donderis
J M
JM
Lloris
D000818:Animals; D016729:Leuprolide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects* / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D013739:Testosterone; D016729:Leuprolide
Cambios anatomopatológicos en el testículo tras un tratamiento prolongado con agonistas LHRH. Estudio experimental en ratas.