Interleukin-6 as a marker of hepatic metabolism following hepatectomy.
This study evaluated the clinical significance of interleukin-6 levels after hepatectomy. Thirty-one patients who underwent hepatectomies were examined. Perioperative data involving serum laboratory tests, serum concentrations of interleukin-6, and liver energy status as indicated by arterial ketone body ratio (AKBR) were analyzed. In each patient, the maximum concentration of interleukin-6 in the postoperative course (IL-6-M) was observed by the 2nd postoperative day. IL-6-M correlated significantly with the maximum concentration of total bilirubin and with the postoperative decrease in AKBR. IL-6-M also correlated with the duration of surgery and blood loss, but no relationship with aminotransferase was found. We conclude that after hepatectomy IL-6-M may be a marker for the metabolic status of the liver as well as operative stress, and is useful because it can be evaluated in the early postoperative period.
Department of Surgery II, Nagoya University School of Medicine, Tsuruma, Japan.
H
H
Maruyama
A
A
Harada
T
T
Kurokawa
T
T
Nonami
A
A
Nakao
H
H
Takagi
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006498:Hepatectomy; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013997:Time Factors
D015415:Biomarkers; D015850:Interleukin-6; D007657:Ketone Bodies; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin