[Treatment of pulmonary vasculitis].
Pulmonary vasculitides require major therapeutic regimens which, though symptomatic, are often effective. Corticosteroids have greatly changed the prognosis of most of these vasculitides, particularly polyarteritis nodosa and the Churg and Strauss syndrome. Cyclophosphamide must be added for Wegener's granulomatosis although the route of administration is still under discussion. Plasma exchanges are rarely indicated. Other treatments for Wegener's granulomatosis including combined trimethoprim-sulfamethoxazole in limited forms and methotrexate in sub-acute systemic forms are currently under study. A better understanding of the underlying mechanisms, including the role of antineutrophil cytoplasmic antibodies, and especially the identification of the causative factors will lead to an aetiologic treatment still unknown today.
Piette
J C
JC
Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Du
L T
LT
Cacoub
P
P
Papo
T
T
Wechsler
B
B
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015267:Churg-Strauss Syndrome / Q000628:therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000628:therapy*; D010951:Plasma Exchange; D010488:Polyarteritis Nodosa / Q000628:therapy; D014657:Vasculitis / Q000628:therapy*
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide
Traitement des vascularites pulmonaires.