Effects of the H2-antagonists famotidine and nizatidine and the cytoprotectant misoprostol on human colonic and rat peritoneal mast cells.
The H2-antagonists famotidine and nizatidine produced a dose-dependent inhibition of histamine release from human colonic mucosal and muscle mast cells stimulated with anti-IgE. The IC30 values were in the range 0.5-10 microM and the maximum inhibition approached 50%. The compounds showed similar efficacy against rat peritoneal mast cells but were more potent. The cytoprotectant misoprostol had a striking effect on the human colonic mast cells, producing more than 50% inhibition at concentrations of 0.1-1 nM, but was much less active against the rat cells.
Department of Chemistry, University College London, UK.
P M
PM
Shah
P B
PB
Boulos
R
R
Springall
R
R
Vashisht
F L
FL
Pearce
D000818:Animals; D003106:Colon / Q000166:cytology; D015738:Famotidine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects*; D016595:Misoprostol / Q000494:pharmacology*; D016567:Nizatidine / Q000494:pharmacology*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats
D006635:Histamine H2 Antagonists; D016595:Misoprostol; D015738:Famotidine; D016567:Nizatidine