Reproducibility of magnetic resonance spectroscopy in patients undergoing dialysis and evaluation of the therapeutic response of tumors.
OBJECTIVE
The reproducibility of repeated magnetic resonance (MR) spectroscopy was studied in patients undergoing dialysis and treatment of a variety of malignant tumors.


METHODS
Localized MR spectra were obtained using a 1.5-T system by image-selected in vivo spectroscopy. Total metabolite signal was integrated between phosphomonoester and beta-adenosine triphosphate resonance. We termed this measurement AREA.


RESULTS
Intrapatient variability was evaluated on repeated thigh muscle spectroscopy for 10 patients. Sequential spectra of 10 malignant tumors of the extremities were analyzed and compared with the histology of surgical specimens in seven patients. Intrapatient variability in AREA was calculated as 14.0%. The extent of necrosis and AREA ratio (definition: AREA post-therapy/AREA pretherapy) were as follows; 6.1% in > 90% necrosis, 43% in 50% to 90% necrosis, and 79% in < 50% necrosis.


CONCLUSIONS
Localized MR spectra are fairly reproducible and may relate to treatment efficacy.
Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Japan.
K
K
Imamura
H
H
Ashida
H
H
Nakajima
M
M
Takagi
K
K
Ohashi
M
M
Saeki
A
A
Fukui
M
M
Endo
T
T
Ishikawa
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D012516:Osteosarcoma / Q000378:metabolism* / Q000628:therapy; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000628:therapy; D013848:Thigh