A versatile approach to the synthesis of combretastatins.
A new and versatile synthesis of combretastatins has been developed. Starting from commercially available materials, 2-phenyl-2-benzyl-1,3-dithianes were easily prepared and used as intermediates in the synthesis of several families of combretastatins. This approach facilitates the preparation of representative intermediates in a few steps, with or without an oxygenated function in the ethylenic residue. Many different analogues suitable for pharmacological evaluation can also be obtained from some of these intermediates.
Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Salamanca, Spain.
M
M
Medarde
R
R
Peláez-Lamamié de Clairac
J L
JL
López
A
A
San Feliciano
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D001632:Bibenzyls / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes
D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin