Evaluation of curative anticryptosporidial activity of paromomycin in a dexamethasone-treated rat model.
A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of paromomycin per kg of body weight per day.
Institut National de la Santé et de la Recherche Médicale, Hôpital Bichat-Claude-Bernard, Paris, France.
R
R
Verdon
J
J
Polianski
C
C
Gaudebout
C
C
Marche
L
L
Garry
J J
JJ
Pocidalo
D000818:Animals; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D016785:Cryptosporidium parvum; D003907:Dexamethasone; D004195:Disease Models, Animal; D005260:Female; D010303:Paromomycin / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010303:Paromomycin; D003907:Dexamethasone