Bioavailability of hydrocortisone acetate from ophthalmic ointments.
The biopharmaceutical studies of 1% hydrocortisone acetate ophthalmic ointments were carried out with isolated pig's eyes and demonstrated that the drug concentration in intraocular fluids depended on: a) ointment base used - the best bioavailability was obtained using white petrolatum with addition of 10% anhydrous lanolin, b) eye fluid examined - concentration of hydrocortisone acetate in aqueous humor was several times higher than in vitreous humor, c) presence of corneal epithelium - in all studied cases abrasion of corneal epithelium was accompanied by well-marked increase of drug concentration in intraocular fluids.
Department of Applied Pharmacy, School of Medicine, Lublin, Poland.
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D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism*; D001682:Biological Availability; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D007809:Lanolin; D009824:Ointments; D009885:Ophthalmology; D010577:Petrolatum; D013552:Swine; D014822:Vitreous Body / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D009824:Ointments; C021650:hydrocortisone acetate; D007809:Lanolin; D010577:Petrolatum; D006854:Hydrocortisone