Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D.
The structure of a unique polythiazole-containing cyclic peptide antibiotic, amythiamicin D, was elucidated by chemical degradations and NMR spectral analyses. Acid hydrolysis of amythiamicin D gave one mole of glycine and three new amino acids. Structures of N-acetyl-O-methyl derivatives of these new amino acids were determined by NMR and UV spectral analyses. Connectivities of these amino acids were determined by HMBC experiments.
Shimanaka
K
K
Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan.
Takahashi
Y
Y
Iinuma
H
H
Naganawa
H
H
Takeuchi
T
T
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006851:Hydrochloric Acid; D006868:Hydrolysis; D047028:Macrocyclic Compounds; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013844:Thiazoles
D000900:Anti-Bacterial Agents; D047028:Macrocyclic Compounds; D013844:Thiazoles; C088501:amythiamicin D; D006851:Hydrochloric Acid