[Directions in the development of postsynaptic nondepolarizing muscle relaxants with rapidly developing action].
The experiments on unconscious cats have shown that the myoparalytic effect of postsynaptic non-depolarizing myorelaxants which have a trimethylammonium cationic group develops more rapidly than that of their triethylammonium analogues. The compound IEM-1213 is given as an example of a trimethylammonium derivative with the rigid structure of the molecule having an unusual rapidly developed effect.
A F
AF
Danilov
E P
EP
Zhabko
Iu D
IuD
Fedorov
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013997:Time Factors
D003473:Neuromuscular Nondepolarizing Agents
O napravleniiakh razrabotki postsinapticheskikh nedepoliarizuiushchikh myshechnykh relaksantov s bystro razvivaiushchimsia deĭstviem.