Profound shock resulting from a large dose of dipyridamole.
Acute ingestion of more than 200 mg dipyridamole may result in minor symptoms. The reported highest dosage of acute ingestion was 1250 mg. Most experiences of acute ingestion come from dipyridamole thallium image, oral application of 300-400 mg or intravenous 0.56 mg/kg. The systemic or cardiovascular complication could be rapidly reversed by intravenous use of aminophylline, 50-240 mg. We report an experience in dealing with the highest ever dose, 1750 mg, of dipyridamole overdose by usual dose of aminophylline.
Chen
Z C
ZC
Department of Internal Medicine, National Cheng-Kung University Medical College and Hospital, Tainan, Taiwan.
Kwan
C M
CM
Chen
J H
JH
D000328:Adult; D000628:Aminophylline / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced; D004176:Dipyridamole / Q000008:administration & dosage / Q000506:poisoning*; D004298:Dopamine / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D006801:Humans; D011041:Poisoning / Q000188:drug therapy; D012769:Shock / Q000139:chemically induced*
D000628:Aminophylline; D004176:Dipyridamole; D004298:Dopamine