Angiotensin-converting enzyme inhibitor-induced pemphigus: three case reports and literature review.
OBJECTIVE
To identify patients examined in the Mayo Clinic Department of Dermatology whose pemphigus was attributable to an angiotensin-converting enzyme inhibitor and to compare these cases with previously reported cases of drug-induced pemphigus.


RESULTS
A retrospective review of medical records revealed two cases of captopril-induced pemphigus and one of enalapril-induced pemphigus. Our patients had substantially increased circulating IgG autoantibodies to intercellular substance, as detected on monkey esophagus substrate.


CONCLUSIONS
Our findings contrast those of other reports of drug-induced pemphigus in which circulating autoantibodies are implied to be low or absent.
Kuechle
M K
MK
Department of Dermatology, Mayo Clinic Rochester, MN 55905.
Hutton
K P
KP
Muller
S A
SA
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D002216:Captopril / Q000009:adverse effects*; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology
D001323:Autoantibodies; D004656:Enalapril; D002216:Captopril