Fenfluramine-induced modification of palatability: analysis by the taste reactivity test.
The ability of various doses (0, 1.25, 2.5, and 5.0 mg/kg) of fenfluramine to modify the palatability of sucrose and quinine solutions was assessed by means of the taste reactivity test. Although fenfluramine did not modify the positive hedonic ingestive reactions elicited by sucrose solution, it consistently enhanced the negatively hedonic aversive reactions elicited by unpalatable 0.05% quinine solution and moderately palatable 2% sucrose solution. The results suggest that fenfluramine enhances the aversive properties of tastants without suppressing the positive hedonic properties of tastants. The results support a two-dimensional model of palatability.
Barnfield
A
A
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Parker
L A
LA
Davies
A M
AM
Miles
C
C
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D005277:Fenfluramine; D013395:Sucrose; D011803:Quinine