Histamine is a powerful stimulator of cyclic AMP formation in chick pineal gland.
Histamine (HA) potently stimulated both basal and forskolin-activated cAMP formation in chick pineal gland. The action of HA was mimicked by 4-methyl-HA, and to some extent by 2-methyl-HA and 2-thiazolylethylamine (2TEA), but not by dimaprit, (R)-alpha-methyl-HA tele-methyl-HA, and several other imidazole-derivatives. The stimulatory actions of all the compounds were antagonized by ranitidine and tiotidine (HA H2-receptor antagonists), and were not affected by mepyramine and thioperamide (HA H1- and H3-receptor blockers, respectively). These data indicate that the chick pineal probably contains H2-like HA receptors, whose stimulation leads to increases in cAMP production.
Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
J Z
JZ
Nowak
B
B
Sek
D000818:Animals; D002645:Chickens; D000242:Cyclic AMP / Q000096:biosynthesis*; D006632:Histamine / Q000494:pharmacology*; D017442:Histamine Agonists / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D013268:Stimulation, Chemical
D017442:Histamine Agonists; D006633:Histamine Antagonists; D006632:Histamine; D000242:Cyclic AMP