Efficacy of a standard human anthrax vaccine against Bacillus anthracis spore challenge in guinea-pigs.
The efficacy of an anthrax vaccine licensed for human use, MDPH-PA, was tested in guinea-pigs intramuscularly challenged with 10, 100 or 1000 LD50 of spores from two virulent strains of Bacillus anthracis, Vollum 1B and Ames. As demonstrated in other investigations, immunization with MDPH-PA provided better protection against challenge with the Vollum 1B strain than with the Ames strain, although vaccine efficacy against the Ames strain was better than previously reported. Enzyme-linked immunosorbent assay of serum antibody titres to B. anthracis protective antigen showed that there was no significant correlation between survival and antibody titres.
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011.
B E
BE
Ivins
P F
PF
Fellows
G O
GO
Nelson
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001408:Bacillus anthracis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D013171:Spores, Bacterial
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines