An association of polymyalgia rheumatica with myelodysplastic syndromes.
Myelodysplastic syndromes are a group of clonal hematopoietic stem cell disorders leading to peripheral cytopenias and a high probability of leukemic transformation. Immunological abnormalities, both humoral and cell mediated immunity, as well as vasculitis, a "lupus-like syndrome," neuropathy, and arthritis have been described in association with myelodysplastic syndromes. We describe 3 cases of polymyalgia rheumatica (PMR) developing within 4 months of detection of cytopenia. The possible association of myelodysplastic syndromes and PMR has not been previously recognized.
Division of Arthritis and Rheumatic Diseases, Oregon Health Sciences University, Portland.
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Kohli
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Bennett
D000368:Aged; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications* / Q000473:pathology; D011111:Polymyalgia Rheumatica / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
D011241:Prednisone; D008727:Methotrexate