Aging and the brain.
This review considers some of the changes that occur during aging in the mammalian central nervous system. We focus particularly on neurotransmitter systems, calcium homeostasis, synaptic transmission, oxidative metabolism, amyloid deposition, and other neuropathological and anatomical features. Changes during aging in both humans and nonhuman mammals are discussed.
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
J E
JE
Goldman
N Y
NY
Calingasan
G E
GE
Gibson
D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002450:Cell Communication / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D018377:Neurotransmitter Agents