[A case report of rectal cancer with lymph node metastasis effectively treated by neoadjuvant chemotherapy of 5-FU oral and low-dose CDDP transarterial administration].
A 52-year-old man was diagnosed as having rectal cancer. Miles' operation with regional lymph node dissection was performed in April 1989. CT scanning and MRI examination performed in May 1992 showed local recurrence in a lymph node of the pelvic cavity (282). We implanted a catheter in the left internal iliac artery and connected it to an implanted injection port through a subcutaneous tunnel. 5-FU was administered orally at 300 mg daily. CDDP was injected through an injection port at a dose of 20 mg/body/day twelve times and 10 mg/body/day six times. CT scanning showed a change in the size of the tumor, with a reduction rate of 75%. Thereafter, we performed a radical operation in September 1992. The histopathological effect was Grade 2.
Dept. of Surgery, Otaru Ekisaikai Hospital.
T
T
Takamuro
K
K
Sasaki
Y
Y
Konishi
Y
Y
Takada
K
K
Hirata
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D002945:Cisplatin; D005472:Fluorouracil