The human growth-arrest-specific gene GAS1 maps outside the candidate region of the gene for nevoid basal cell carcinoma syndrome.
The human growth-arrest specific gene GAS1 maps to chromosome bands 9q21.3-->q22, the region known to contain the tumour suppressor gene responsible for nevoid basal cell carcinoma syndrome (NBCCS). Because of its putative action as a tumour suppressor gene, the GAS1 gene was analysed as a candidate for the NBCCS gene. Using two-colour fluorescence in situ hybridization, the GAS1 gene maps outside the interval which, by genetic analysis, has been shown to contain the NBCCS gene.
Wicking
C
C
Centre for Molecular Biology and Biotechnology, University of Queensland, Australia.
Breen
M
M
Negus
K
K
Berkman
J
J
Evdokiou
A
A
Cowled
P
P
Chenevix-Trench
G
G
Wainwright
B
B
D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics*; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D003360:Cosmids; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000166:cytology; D005810:Multigene Family; D012097:Repressor Proteins / Q000235:genetics*
D012097:Repressor Proteins