Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity.
Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p < 0.01 vs C), they were much higher in patients with AIS (p < 0.001 vs CSA). PC anticoagulant activity was similar in patients and controls. At variance, PS anticoagulant activity was lower in patients with AIS than in those with CSA and controls (p < 0.05), reflecting differences in total PS and C4B-binding protein (C4B-BP) antigen possibly resulting from involvement in the mechanisms of inflammation, complement activation and acute-phase response. The ratios of anticoagulant PS and PC to procoagulant vitamin K-dependent factors IX and II were reduced in AIS patients (0.05 > p > 0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p < 0.05). These results indicate that in patients with acute ischemic cardiac syndromes the markedly increased in vivo thrombin generation is associated with an unbalance between coagulant and anticoagulant vitamin K-dependent factors.
Coagulation Service, I.R.C.C.S. H S. Raffaele, Milano, Italy.
A
A
D'Angelo
S
S
Gerosa
S V
SV
D'Angelo
A
A
Mailhac
A
A
Colombo
A
A
Agazzi
G
G
Mazzola
S
S
Chierchia
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D002908:Chronic Disease; D003167:Complement Activation / Q000502:physiology; D015935:Complement C4b / Q000378:metabolism; D003169:Complement Inactivator Proteins; D005260:Female; D006023:Glycoproteins; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011486:Protein C / Q000378:metabolism*; D017293:Protein S / Q000378:metabolism*; D011951:Receptors, Complement / Q000378:metabolism; D013577:Syndrome; D013917:Thrombin / Q000378:metabolism*
D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D011951:Receptors, Complement; C046193:antithrombin III-protease complex; D015935:Complement C4b; D000990:Antithrombin III; D010447:Peptide Hydrolases; D013917:Thrombin