Assessment of cerebral autoregulation with ultrasound and laser Doppler wave forms--an experimental study in anesthetized rabbits.
The aim of the study was to correlate changes in transcranial Doppler blood flow velocity wave form in the basilar artery with cortical red blood cell flux measured with a laser Doppler flowmeter during hemorrhage-induced hypotension in anesthetized and ventilated New Zealand rabbits. Although systolic flow velocity and flux exhibited an autoregulatory threshold at 45 mm Hg, diastolic flow velocity started to fall when mean arterial blood pressure fell below 65 mm Hg. The difference between the mean arterial blood pressure at which diastolic blood flow velocity decreases and the pressure at which mean flux decreases is the difference between systolic and diastolic blood pressure. The increasing divergence between systolic and diastolic flow velocities was reflected in an increase in the amplitude of blood flow velocity pulsations and pulsatility indices. An increase in flux pulsatile wave form was noted as cerebral resistive vessels dilated with hypotension.
Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom.
M
M
Czosnyka
H
H
Richards
P
P
Kirkpatrick
J
J
Pickard
D000818:Animals; D001488:Basilar Artery / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002540:Cerebral Cortex / Q000098:blood supply; D003971:Diastole / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D017078:Laser-Doppler Flowmetry; D011673:Pulsatile Flow / Q000502:physiology; D011817:Rabbits; D012039:Regional Blood Flow / Q000502:physiology; D013599:Systole / Q000502:physiology; D017585:Ultrasonography, Doppler, Transcranial