[A double-blind study of neostigmine versus placebo in paralytic ileus as a result of surgical interventions].
A fully randomized double-blind study, stratified according to diagnosis, was carried out in order to assess the effect of endonasal neostigmine in the treatment of post-laparotic paralytic ileus. A total of 40 patients (16 M, 24 F), aged between 22 and 76 years old, were admitted to the study; of these 20 were cholecystectomized and 20 had undergone emergency surgery. According to a special randomization list, 10 patients from each pathological group were treated with 6% neostigmine en (1 puff = 5.4 mg) and the other ten were treated with placebo. Both treatments were administered at a dose of 2 puffs, one per nostril, at the end of surgery and then repeated every 4 hours up to a maximum of 6 puffs/day. Treatment was continued for 4 days or until canalization of feces and gas was achieved. The mean daily dose of endonasal neostigmine found to be efficacious was 4 puffs/day, equivalent to 24.7 mg in cholecystectomized patients and 23.5 mg in patients undergoing emergency surgery. In over-all terms the canalization of gas and feces was observed in 74% of patients treated with neostigmine and in 45% of those receiving placebo and the difference was statistically significant.
Istituto di Chirurgia d'Urgenza, Ospedale Molinette, Torino.
E
E
Orlando
F
F
Finelli
M
M
Colla
E
E
Giotto
P
P
Terragni
G
G
Olivero
D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002763:Cholecystectomy; D004311:Double-Blind Method; D004630:Emergencies; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000209:etiology; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000008:administration & dosage*; D010919:Placebos; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology
D010919:Placebos; D009388:Neostigmine
Studio in doppia cecità tra neostigmina en versus placebo nell'ileo paralitico conseguente ad interventi chirurgici.