The effect of C-terminal fragment of ANF-ANF(24-28)OH on the cardiovascular system in rat.
1. The effect of C-terminal fragment of ANF-ANF(24-28)OH on the cardiovascular system was investigated in rats. 2. In vivo this pentapeptide caused the fall of systolic and diastolic blood pressure. 3. ANF(24-28)OH increased cardiac contraction amplitude and changed coronary outflow in vitro. 4. These experiments showed that the shorter fragment of ANF containing five amino acids: Asn24-Ser25-Phe26-Arg27-Tyr28-COOH is a bioactive substance.
Department of Pharmacology, Medical Academy, Bialystok, Poland.
B
B
Mikoluc
R J
RJ
Wisniewska
D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008969:Molecular Sequence Data; D009200:Myocardial Contraction / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor