Emergence of symptoms of Tourette's syndrome during fluvoxamine treatment of obsessive-compulsive disorder.
A 14-year-old boy with obsessive-compulsive disorder (OCD) developed, under fluvoxamine treatment, acute symptoms of Tourette's syndrome (TS) with aggravation of the OCD. The TS symptoms did not respond to dopamine blockers and disappeared only after withdrawal of fluvoxamine. Readministration of fluvoxamine caused a re-emergence of the same symptoms.
Department of Psychiatry, State University of New York at Stony Brook.
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Weitzman
D000293:Adolescent; D001143:Arousal / Q000187:drug effects; D004359:Drug Therapy, Combination; D016666:Fluvoxamine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008152:Loxapine / Q000627:therapeutic use; D008297:Male; D009460:Neurologic Examination; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced / Q000188:drug therapy*; D012008:Recurrence; D013469:Sulpiride / Q000627:therapeutic use; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000523:psychology
D013469:Sulpiride; D008152:Loxapine; D016666:Fluvoxamine