Effects of endotoxin and cytokines on lipid metabolism.
Endotoxin, via cytokines, induces marked changes in lipid metabolism: serum VLDL increases, whereas the effect on LDL levels varies among species. The increase in VLDL is caused by stimulation of hepatic VLDL secretion or inhibition of clearance, or both. These alterations can be deleterious or beneficial effects.
Department of Medicine, University of California, San Francisco.
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Hardardóttir
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Grünfeld
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Feingold
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology*; D050356:Lipid Metabolism; D014280:Triglycerides / Q000378:metabolism
D016207:Cytokines; D004731:Endotoxins; D014280:Triglycerides; D002784:Cholesterol