[Effect of histone on hematopoietic stem cells (CFU-S) in normal and irradiated organism].
Radiotherapeutic activity of histone fractions H1 and H2A/H2B were studied. It was demonstrated that both fractions are able to reduce the damaging effect of ionizing radiation on spleen colony forming unit (CFU-S) population. Histone preparations stimulated colony-forming activity of bone marrow cells exposed to dose of 0.5-3.0 Gy both in the case of incubation with preparations and intravenous or intraperitoneal administration into recipients of irradiated cells. The effect of histones and accessory thymocytes on CFU-S population is compared.
Semina
O V
OV
Semenets
T N
TN
Zeppezauer
M
M
Cebecauer
L
L
Poverennyĭ
A M
AM
D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000528:radiation effects*; D006657:Histones / Q000494:pharmacology*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011836:Radiation Tolerance; D013154:Spleen / Q000473:pathology / Q000528:radiation effects
D006657:Histones
Vozdeĭstvie gistona na krovetvornye kletki-predshestvenniki (KOEs) normal'nogo i obluchennogo organizma.