A rat model of phencyclidine psychosis.
Phencyclidine (PCP)-induced behavior in rats was investigated in water maze and diving behavior tasks. The swimming and diving latencies of PCP-treated groups placed in a water maze apparatus were gradually shortened, and prolonged, respectively, while rats in a control group performed well. In all rats, stereotyped behavior and hyperlocomotion were absent. We propose that this animal model induced by lower doses of PCP may be useful for further studies to research schizophrenia.
Ogawa
S
S
Research Center, Taisho Pharmaceutical Co., Ltd., Ohmiya, Saitama, Japan.
Okuyama
S
S
Araki
H
H
Nakazato
A
A
Otomo
S
S
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D010622:Phencyclidine / Q000494:pharmacology*; D011605:Psychoses, Substance-Induced; D051381:Rats; D017208:Rats, Wistar
D010622:Phencyclidine