Invasive group A streptococcus carriage in a child care centre after a fatal case.
After a fatal case of invasive group A streptococcal disease, serotype T-1, in a child care centre, group A streptococcal T-1 prevalence was measured and risk factors for carriage were determined. A total of 87% (224/258) had throat culture tests. Group A streptococcus was isolated from 57 (25%), and of the 50 isolates serotyped, 38 (76%) were T-1. Group A streptococcal T-1 prevalence was 18% (38/217) and six of nine rooms had children with group A streptococcal T-1 isolates. The risk of group A streptococcal T-1 carriage was increased for children who shared the index case's room (odds ratio (OR) = 2.7; 95% confidence interval (CI) = 0.8 to 9.4) and for each additional hour per week in child care (OR = 1.03; 95% CI = 1.001 to 1.061); and decreased in children taking antibiotics in the preceding four weeks (OR = 0.2; 95% CI = 0.1 to 0.9). Carriage of the invasive group A streptococcal strain could not be determined by identified risk factors alone.
Engelgau
M M
MM
Epidemic Intelligence Service, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia.
Woernle
C H
CH
Schwartz
B
B
Vance
N J
NJ
Horan
J M
JM
D000328:Adult; D000407:Alabama / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002353:Carrier State / Q000453:epidemiology*; D002656:Child Day Care Centers; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010614:Pharynx / Q000382:microbiology*; D015995:Prevalence; D012307:Risk Factors; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D013297:Streptococcus pyogenes / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents