[Evaluation of Abbott CD 3500 in severe leukopenia].
Leucopenia patient follow-up remains, in terms of laboratory turnaround, a heavy workload due to the leucoconcentrations necessary for evaluating leucocytic formulas. We tested the CD 3500 with the objective of defining its' analytical performances and routine practice. 101 leucopenia samples (< 2.10(9)/l) procured from the onco-hematology department (adults and children) were studied during a 1 month period. The leucocytic formula obtained after leuconcentrations was our reference. The alarm sensitivity, as a whole, was of 97% for a 15.5% specificity. The correlation coefficients (Cell-Dyn/microscope) for polynuclears, lymphocytes and monocytes were respectively 0.889, 0.925 and 0.926. The correlation coefficients observed in both following subgroups: < or = 0.5.10(9)/l and > 0.5.10(9)/l were superposable. In 95% of the cases, the numeric value difference between the two methods attained a maximum of 21% for all neutrophils and lymphocytes and 13% for the monocytes. There was an excellent concordance between both methods for eosinophilia and basophils with confidence intervals of +/-8.8% and +/-2.2%. In practice, we feel that the use of a CD 3500 in post chemotherapy leucopenia, is perfectly adaptable and appreciated for leucocytic formulas, as well as a good exit for aplasia.
Hôpital Claude Huriez, Laboratoire d'Hématologie, CHRU, Lille, France.
M
M
Fournier
A
A
Gireau
B
B
Boniface
C
C
Ghevaert
P
P
Lepelley
M
M
Zandecki
J
J
Goudemand
A
A
Cosson
D001322:Autoanalysis / Q000295:instrumentation*; D005069:Evaluation Studies as Topic; D006405:Hematology / Q000295:instrumentation*; D006801:Humans; D007970:Leukopenia / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
Evaluation du CD 3500 Abbott dans les leucopénies profondes.