Food deprivation does not influence body or selection temperature in rats receiving intraventricular bombesin.
Bombesin (BBS), a tetradecapeptide, has been found to have potent hypothermic effects when centrally administered. This study was designed to investigate the relationship between food-deprivation and BBS-induced hypothermia in a temperature selection paradigm. Food-deprived and satiated male Sprague-Dawley rats were given intracerebroventricular (ICV) injections of several doses of BBS and control vehicle. Selection temperature data and changes in core body temperature were measured. BBS produced a significant hypothermia and decrease in selection temperatures in all doses but one. No significant differences in body temperature or selection temperatures were found between food-deprived and satiated animals. The results are consistent with the hypothesis that BBS acts centrally to decrease body temperature set point.
Department of Psychology, Colorado State University, Fort Collins 80523.
B S
BS
Stump
A J
AJ
Bane
D D
DD
Avery
D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology*; D001833:Body Temperature Regulation / Q000187:drug effects; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004777:Environment; D005508:Food Deprivation / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D001839:Bombesin