[The chronobiological aspects of drug resistance to antianginal therapy].
Two groups of ischemic heart disease patients with different responses to antianginal therapy (propranolol, nifedipine) were studied. Mathematical analysis of heart rate variabilities showed that tolerant patients had a low index of centralization, lack of its circadian rhythm and a low correlation between several cardiointervalographic parameters. Bearing in mind these shifts makes it possible to predict the therapeutical efficiency of the antianginal drugs.
Arushanian
E B
EB
Shamliian
T A
TA
D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002909:Chronobiology Phenomena / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects; D003692:Delayed-Action Preparations; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology; D009566:Nitrates / Q000627:therapeutic use; D018709:Statistics, Nonparametric
D003692:Delayed-Action Preparations; D009566:Nitrates
Khronobiologicheskie aspekty farmakorezistentnosti k antianginal'noĭ terapii.