[A position effect variegation model of chromatin compaction].
A position effect variegation (PEV) model of chromatin compaction is proposed, based on the concept of a statistical distribution of compaction protein (CP) molecules around compaction initiation centers (CICs). The principles of the model are as follows: (1) CICs are present in both hetero- and euchromatin, and (2) different CP molecules interact not only with DNA but also with one another, forming a multimeric complex. When a certain level of DNA-protein binding is exceeded, heterochromatic domains are formed. The model suggests that continuous and discontinuous chromatin compaction resulting from PEV is due to an irregular CIC distribution along the chromosome.
Balasov
M L
ML
Makunin
I V
IV
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D008957:Models, Genetic; D009030:Mosaicism
D002843:Chromatin; D004268:DNA-Binding Proteins
Model' kompaktizatsii khromatina pri mozaichnom éffekte polozheniia gena.