H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response.
Microbial elicitors or attempted infection with an avirulent pathogen strain causes the rapid production of reactive oxygen intermediates. We report here that H2O2 from this oxidative burst not only drives the cross-linking of cell wall structural proteins, but also functions as a local trigger of programmed death in challenged cells and as a diffusible signal for the induction in adjacent cells of genes encoding cellular protectants such as glutathione S-transferase and glutathione peroxidase. Thus, H2O2 from the oxidative burst plays a key role in the orchestration of a localized hypersensitive response during the expression of plant disease resistance.
Plant Biology Laboratory, Salk Institute, La Jolla, California 92037.
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A
Levine
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R
Tenhaken
R
R
Dixon
C
C
Lamb
D015152:Blotting, Northern; D016923:Cell Death; D002478:Cells, Cultured; D015870:Gene Expression; D017343:Genes, Plant; D005979:Glutathione Peroxidase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007113:Immunity, Innate / Q000502:physiology; D010935:Plant Diseases; D010957:Plasmids; D018749:RNA, Plant / Q000032:analysis / Q000378:metabolism; D016897:Respiratory Burst; D015398:Signal Transduction; D013025:Glycine max / Q000166:cytology / Q000502:physiology*; D014158:Transcription, Genetic
D018749:RNA, Plant; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase