Biphasic time-course of serum concentrations of clomipramine and desmethylclomipramine after a near-fatal overdose.
A 27-y-old male was admitted deeply comatosed 5-6 h after taking approximately 15 g clomipramine. The prominent feature of the case was a biphasic course of clomipramine and desmethylclomipramine serum concentrations, possibly caused by delayed drug absorption. Clinically, 2 serious episodes requiring mechanical ventilation and aggressive pressor agent infusions occurred as the serum concentrations declined. However, the severe adult respiratory distress syndrome--related inflammatory process that required 4 w of intensive care may also be an explanation, although blood cultures were negative and neither liver nor renal functions were severely compromised.
Department of Pharmacology and Toxicology, University of Trondheim Medical Center-Regionsykehuset i Trondheim, Norway.
O
O
Dale
A
A
Hole
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood* / Q000506:poisoning*; D062787:Drug Overdose; D006207:Half-Life; D006801:Humans; D008297:Male
C012273:desmethylclomipramine; D002997:Clomipramine