Transcription by RNA polymerase II: a process linked to DNA repair.
The proteins that are implicated in the basal transcription of protein coding genes have now been identified. Although little is known about their function, recent data demonstrate the ability of these proteins, previously called class II transcription factors, to participate in other reactions: TBP, the TATA-box binding factor, is involved in class I and III transcription, while TFIIH has been shown to possess components that are involved in the DNA repair mechanism. The involvement of some if not all of the TFIIH subunits in transcription and repair may explain the heterogeneity of the various and sometimes completely unrelated symptoms observed in xeroderma pigmentosum, Cockayne Syndrome and trichothiodystrophy disorders.
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U184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Moncollin
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Egly
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D000818:Animals; D003057:Cockayne Syndrome / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D012319:RNA Polymerase II / Q000235:genetics*; D016385:TATA Box / Q000235:genetics; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000235:genetics; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000235:genetics
D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D012319:RNA Polymerase II