New aporphine alkaloids from guatteria foliosa.
Four new alkaloids were obtained from Guatteria foliosa, namely, the noraporphines (-)-3-methoxyputerine [1] and (+)-norguattevaline [2], the more highly oxidized (+)-3-methoxyguattescidine [3], and the oxoaporphine 3-methoxyoxoputerine [4]. Among several other known alkaloids also found in this same plant, (-)-3-hydroxynornuciferine, (-)-isoguattouregidine, and argentinine exhibited significant activity against Trypanosoma cruzi.
Mahiou
V
V
Laboratoire de Pharmacognosie, URA 1843 CNRS (BIOCIS), Faculté de Pharmacie, Université de Paris XI, Châtenay-Malabry, France.
Roblot
F
F
Hocquemiller
R
R
Cavé
A
A
Rojas de Arias
A
A
Inchausti
A
A
Yaluff
G
G
Fournet
A
A
Angelo
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001060:Aporphines / Q000302:isolation & purification*; D001838:Bolivia; D007891:Leishmania / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D001060:Aporphines