Chronic social stress conditions differentially modify vulnerability to amphetamine self-administration.
Using social instability and cohabitation with females as chronic stress, we observed that neuroendocrine systems were differentially activated according to the experimental design. We show here that amphetamine self-administration, a paradigm to study the reinforcing effects of psychostimulants, is also differentially affected by these conditions. Coexistence with females increases amphetamine self-administration and this effect is reduced when social instability is superimposed. On the other hand, locomotor response to amphetamine is not modified by either social factor, suggesting a specific involvement of a subset of dopaminergic neurons.
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259-INRA, Université de Bordeaux II, France.
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D000661:Amphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004777:Environment; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012646:Self Administration; D012919:Social Behavior; D013315:Stress, Psychological / Q000523:psychology*
D000661:Amphetamine