Chronic effects of ethanol on central adenosine function of mice.
Chronic ingestion of 5% ethanol had no significant effect on open field locomotor of NIH Swiss strain male mice, nor were the depressant effects of a non-selective adenosine receptor agonist, NECA, or the stimulant effects of a non-selective antagonist, caffeine significantly altered. The density of cerebral cortical A1-adenosine receptors and of nitrendipine binding sites on calcium channels were significantly increased after chronic ethanol, while the density of striatal A2a-adenosine receptors were unchanged. The locomotor stimulant effects of ethanol (2.5 g/kg) were slightly decreased after chronic ethanol, but were markedly reduced in mice after chronic caffeine ingestion. The results suggest some involvement of adenosine systems in the effects of ethanol.
Daly
J W
JW
Laboratory of Bioorganic Chemistry, National Institutes of Health, Bethesda, MD 20892.
Shi
D
D
Wong
V
V
Nikodijevic
O
O
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D001921:Brain / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D058915:Purinergic P1 Receptor Antagonists; D011869:Radioligand Assay; D018047:Receptors, Purinergic P1 / Q000187:drug effects*; D013997:Time Factors
D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D019830:Adenosine-5'-(N-ethylcarboxamide); D002110:Caffeine; D000431:Ethanol; D000241:Adenosine