Circadian rhythms, jet lag, and chronobiotics: an overview.
This overview considers the origins of jet lag in terms of altered circadian rhythmicity. The properties required of a chronobiotic--an agent to cause phase adjustment of the body clock--are discussed, and an account is given of the major candidates at the present time: light, melatonin, activity, and benzodiazepines. It is concluded that current knowledge indicates that a combination of factors is likely to be most effective.
School of Pharmacy and Pharmacology, University of Bath, England.
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P
Redfern
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D
Minors
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J
Waterhouse
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D001683:Biological Clocks; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008027:Light; D008550:Melatonin / Q000494:pharmacology; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000502:physiology; D014195:Travel
D001569:Benzodiazepines; D008550:Melatonin