[Adrenal cortex suppression attributed to the use of budesonide].
The Netherlands Centre for Monitoring of Adverse Reactions to Drugs received two reports of adrenal suppression, attributed to inhaled budesonide. In the first patient, a 7-year-old girl, there were growth retardation, centripetal weight gain and a Cushingoid moonface with unmeasurable serum levels of cortisol after long-term treatment with 600, and later 1000 micrograms daily. In the second patient, an 8-year-old boy, there was malaise with onset a few months after start of treatment with 400 micrograms budesonide daily. There was a lowered serum level of cortisol which returned to normal after discontinuation of budesonide. Although inhaled corticosteroids cause systemic adverse effects less frequently than orally administered corticosteroids, such effects may occur occasionally.
van Heest
J A
JA
Erasmus Universiteit, Huisartsinstituut, Rotterdam.
Bokma
J A
JA
van Oudheusden
L J
LJ
Stricker
B H
BH
D000287:Administration, Topical; D000302:Adrenal Cortex / Q000187:drug effects; D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000336:Aerosols; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000009:adverse effects*; D019819:Budesonide; D002648:Child; D003480:Cushing Syndrome / Q000139:chemically induced; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008297:Male; D011282:Pregnenediones / Q000009:adverse effects* / Q000627:therapeutic use
D000336:Aerosols; D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D011282:Pregnenediones; D019819:Budesonide
Bijnierschorsremming toegeschreven aan het gebruik van budesonide.