Efficacy of cefazolin in promoting ovine tracheal epithelial repair.
Inhalation of toxic materials has been shown injurious to the upper airways. Because secondary infection can slow the repair process, we undertook this study to determine the efficacy of antibiotic therapy in promoting the healing process of acute tracheal wounds. In 18 anesthetized sheep, a portion of the cervical trachea was exposed to smoke from smoldering cotton cooled to 38 degrees C. Nine received the broad-spectrum antibiotic, cefazolin, while none received saline placebo. At 13 days after injury, nonciliated and ciliated cell counts were 75% and 33% respectively of noninjured trachea receiving placebo, while in those receiving cefazolin, nonciliated and ciliated cell counts increased to 93% and 114% of paired noninjured trachea, respectively. We suggest that cefazolin therapy allows cell proliferation and differentiation to proceed more rapidly than observed with placebo therapy and thus may be a helpful augmentor to the healing of an acute airway injury.
Barrow
R E
RE
Department of Surgery, Shriners Burns Institute, Galveston, TX 77550.
Wang
C Z
CZ
Yang
S F
SF
Zhu
Q
Q
Cox
R A
RA
D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D002437:Cefazolin / Q000627:therapeutic use*; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002923:Cilia / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D037102:Lectins; D008938:Mitosis / Q000187:drug effects; D010919:Placebos; D012756:Sheep; D015208:Smoke Inhalation Injury / Q000628:therapy*; D013997:Time Factors; D014132:Trachea / Q000187:drug effects* / Q000473:pathology
D037102:Lectins; D010919:Placebos; D002437:Cefazolin