[Neuroendocrine carcinoma of the pancreas with the hyperinsulinism syndrome].
In a 26-year-old woman with symptoms of hyperinsulinism explorative laparotomy revealed a pancreatic tumour metastatizing into the liver. Intensive cytostatic therapy led to a temporary inhibition of hyperinsulinism, however, in the course of two years massive infiltration of the retroperitoneum, left adrenal, gastric wall, liver, mesentery and abdominal lymph nodes by a tumour occurred. On necroptic examination the tumour had characteristics of a neuroendocrine carcinoma with carcinoid features. Part of the tumour cells were argyrophil; reliable evidence of insulin production, which during the terminal stage of the disease played again a major part in the clinical picture, was made possible only by the use of a very sensitive Czech made antibody against C peptide.
Dusková
J
J
II. patologicko anatomický ústav, III. interní klinika 1. LF UK a VFN, Praha.
Skrha
J
J
Stolba
P
P
D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology*; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D013577:Syndrome
Neuroendokrinní karcinom pankreatu se syndromem hyperinzulinismu.