Synthesis and cytotoxic activity of new isothiazolo[5,4-d]pyrimidine derivatives.
The synthesis of new 5-amino-3-methylisothiazolo[5,4-d]pyrimidines series is reported. The cytotoxic activity of these compounds has been determined on the two tumor cell lines (P-388 and KB). Two representative compounds 7 and 8 displayed a significant cytotoxic action. The results point a possible involvement of structural features in the inhibition effect against tumors.
Organic Chemistry Department, Faculty of Pharmacy, Medical Academy, Wroclaw, Poland.
U
U
Lipnicka
A
A
Regiec
Z
Z
Machon
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011743:Pyrimidines