The molecular basis for dominant yellow agouti coat color mutations.
Agouti expression during the middle portion of the mouse hair growth cycle induces melanocytes to synthesize yellow instead of black pigment, generating black hairs with a yellow band. Dominant agouti alleles increase the amount of yellow pigment in the coat and are associated with pleiotropic effects including obesity, diabetes and increased tumor susceptibility. Four dominant agouti alleles (Aiapy, Aiy, and Avy) were recently shown to result from insertions that cause ubiquitous expression of chimeric transcripts encoding a wild-type agouti protein(1,2). Three insertions were identified as intracisternal A-particles, which helps explain the variable coat colors and parental imprinting effects associated with some dominant agouti alleles.
Perry
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WL
Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Maryland 21702.
Copeland
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NG
Jenkins
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NA
D054366:Agouti Signaling Protein; D000483:Alleles; D000818:Animals; D005799:Genes, Dominant; D007426:Genes, Intracisternal A-Particle; D006200:Hair Color / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D009154:Mutation; D011506:Proteins / Q000235:genetics
D054366:Agouti Signaling Protein; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C515183:a protein, mouse