A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.
Golub
L M
LM
Department of Oral Biology & Pathology, School of Dental Medicine, State University of New York at Stony Brook 11794-8702.
Evans
R T
RT
McNamara
T F
TF
Lee
H M
HM
Ramamurthy
N S
NS
D000818:Animals; D016866:Bacteroidaceae Infections / Q000188:drug therapy / Q000503:physiopathology*; D001862:Bone Resorption / Q000517:prevention & control*; D017364:Collagenases / Q000378:metabolism; D004318:Doxycycline / Q000627:therapeutic use*; D004789:Enzyme Activation; D018093:Gelatinases / Q000378:metabolism; D005881:Gingiva / Q000201:enzymology*; D008297:Male; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000378:metabolism; D010518:Periodontitis / Q000188:drug therapy / Q000503:physiopathology*; D016966:Porphyromonas gingivalis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013752:Tetracycline / Q000627:therapeutic use*
D061965:Matrix Metalloproteinase Inhibitors; C053450:4-des-dimethylaminotetracycline; D010196:Pancreatic Elastase; D017364:Collagenases; D018093:Gelatinases; D008666:Metalloendopeptidases; D013752:Tetracycline; D004318:Doxycycline