Maternal glucose tolerance and obstetric complications in pregnancies in which the offspring developed type I diabetes.
OBJECTIVE
To identify possible in utero risk factors in children who develop type I diabetes and to determine the risk of development of type I diabetes in the children of women with gestational diabetes.


METHODS
All known children with type I diabetes born at the Mercy Hospital for Women whose mothers had glucose tolerance tests (GTTs) performed during pregnancy were identified. The results of the mothers' GTTs were compared with those of the hospital population, as were their obstetric complications.


RESULTS
We identified 38 children with type I diabetes born at this hospital whose mothers had GTTs performed during pregnancy. Only one of these mothers had gestational diabetes, compared with 5.6% in the overall hospital population (adjusted odds ratio 0.69, 95% confidence interval 0.12-3.84, P = 0.99). There were no differences in the blood glucose levels between the mothers of the children who developed diabetes and the general hospital population. The birth weights of the children destined to develop diabetes also showed no deviation from the expected distribution, and there were no outstanding features of the mothers' obstetric histories.


CONCLUSIONS
Maternal blood glucose level is not an important determinant of the child's risk of developing type I diabetes.
Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Australia.
N A
NA
Beischer
P
P
Wein
M T
MT
Sheedy
G A
GA
Werther
H
H
Gold
D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D016640:Diabetes, Gestational / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D015995:Prevalence; D012016:Reference Values; D012307:Risk Factors
D001786:Blood Glucose