Use of a new sonically cleavable and acido-labile handle for solid-phase peptide amide synthesis.
A new handle usable for solid-phase peptide amide synthesis was designed. New releasing conditions of the peptide using sonication allowed much shorter reaction times at lower TFA concentrations.
Aminoacids and Peptides Laboratory (CNRS), Montpellier University II, France.
M
M
Calmes
J
J
Daunis
D
D
David
R
R
Jacquier
D000577:Amides / Q000138:chemical synthesis*; D000595:Amino Acid Sequence; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis*; D013010:Sonication
D000577:Amides; D010455:Peptides