Chitosan as a novel nasal delivery system for peptide drugs.
A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obtained for concentrations higher than 0.2% and 0.5% in rats and sheep, respectively. The absorption promoting effect was reversible with time in a "pulse-chase" study. Histological examination of the nasal mucosa of rats exposed to a chitosan solution for 60 minutes showed little change.
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DanBioSyst UK Ltd, Albert Einstein Centre, Nottingham, UK.
Farraj
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Davis
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D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008566:Membranes / Q000378:metabolism; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010539:Permeability / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep
D002614:Chelating Agents; D007328:Insulin; D010455:Peptides; D002686:Chitin; D048271:Chitosan