Effect of allylestrenol exposure during pregnancy on the activity of microsomal enzyme system (PSMO) of rat in the F1 and F2 generations.
Treatment of pregnant rats with allyestrenol on the 15th and 19th days of pregnancy induced the activity of enzyme system of adult offspring in females while it did not influence it in males. The steroid anticoncipient treatment of adults decreased the activity of some enzymes of the PSMO. The adulthood anticoncipient steroid treatment of rats which encountered allylestrenol in their fetal age compared to the only anticoncipient steroid treated group produces an increased activity of the majority of the tested parameters both in females and males. The effect of the adulthood alcohol treatment was not influenced by the embryonic treatment with allylestrenol. Differences in the second generation are non-significant.
Department of Biology, Semmelweis University Medical School, Budapest, Hungary.
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Karabélyos
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Szeberényi
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Csaba
D000500:Allylestrenol / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000201:enzymology; D007273:Injections, Intramuscular; D008297:Male; D008431:Maternal-Fetal Exchange; D008862:Microsomes, Liver / Q000201:enzymology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D003577:Cytochrome P-450 Enzyme System; D000500:Allylestrenol