Estrogen and progesterone receptor expression of decidual endometrium in a postmenopausal woman treated with tamoxifen and megestrol acetate.
To the best of our knowledge, this is the first report of in vivo endometrial estrogen and progesterone receptor induction as a result of tamoxifen exposure in a postmenopausal breast cancer patient. The following observations, that the postmenopausal endometrium is sensitive to tamoxifen, that this agent can act as an estrogen-like substance, and that it may cause proliferation of the endometrium in the absence of progestin, may explain the endometrial decidual changes described herein as a protective mechanism against possible neoplastic endometrial changes.
Cohen
I
I
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, Israel.
Shulman
A
A
Altaras
M
M
Tepper
R
R
Cordoba
M
M
Beyth
Y
Y
D001943:Breast Neoplasms / Q000188:drug therapy; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D004717:Endometrium / Q000187:drug effects*; D004967:Estrogens / Q000819:agonists; D005260:Female; D006801:Humans; D008535:Megestrol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D019290:Megestrol Acetate; D008875:Middle Aged; D017698:Postmenopause; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*; D013629:Tamoxifen / Q000494:pharmacology* / Q000627:therapeutic use
D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen; D008535:Megestrol; D019290:Megestrol Acetate