LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents.
Two adolescents with a long history of abuse of lysergic acid diethylamide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syndrome. The similarity in neuroreceptor physiology for both LSD and serotonin suggests that the LSD flashback syndrome may be induced by these drugs in patients with a history of LSD abuse.
Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109.
H
H
Markel
A
A
Lee
R D
RD
Holmes
E F
EF
Domino
D015057:1-Naphthylamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000293:Adolescent; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008238:Lysergic Acid Diethylamide; D008297:Male; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence; D020280:Sertraline; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000209:etiology*; D013577:Syndrome
D000928:Antidepressive Agents; D017374:Paroxetine; D008238:Lysergic Acid Diethylamide; D015057:1-Naphthylamine; D020280:Sertraline