Decreased density of endothelin binding sites in adrenal glands but not in aorta, of long term infarcted rats.
Endothelins (Et-s) are biologically active peptides which play a physiological and pathological role in the cardiovascular regulation. The aim of our study was to verify, in a model of experimental long term myocardial ischemia (15 weeks) in rats, whether there was a modification in the ET binding sites of aorta and adrenal glands. Additionally, Ang II binding sites in adrenal glands were studied. The principal finding of the present study was the down-regulation of ET binding sites in adrenal glands of chronic infarcted rats, whereas no modification of binding parameters for Et-1, in thoracic aorta, nor for Ang II, in adrenal glands, were found.
Dept. of Pharmacology, Sigma-Tau S.p.A., Pomezia-Roma, Italy.
L
L
Vesci
G G
GG
Mattera
M
M
Botarelli
P
P
Tobia
N
N
Corsico
E A
EA
Martelli
D000311:Adrenal Glands / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D001665:Binding Sites; D004195:Disease Models, Animal; D016232:Endothelins / Q000378:metabolism*; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D016232:Endothelins; D000804:Angiotensin II