Influence of 0-(beta-hydroxyethyl)-rutin on the oedema-inhibiting effect of indomethacin.
An experimental investigation was made of the influence of 0-(beta-hydroxyethyl)-rutin (HR) on the effect of indomethacin (1, 2 or 4 mg/kg i.p.) in inhibiting rat paw oedema. HR was given once daily during a 6-day pretreatment, with the final dose 90 minutes before the inflammatory reaction was induced. In the group of HR-pretreated rats which also received indomethacin in a dose of 2 or 4 mg/kg, the extent of the carrageenin-oedema was diminished significantly in comparison to that in experimental animals treated merely with indomethacin.
Institute of Pharmacodynamics, Albert Szent-Györgyi University Medical School, Hungary.
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Blazsó
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Gábor
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D002351:Carrageenan; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use*; D007249:Inflammation; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000925:Anticoagulants; D006896:Hydroxyethylrutoside; C005865:troxerutin; D002351:Carrageenan; D007213:Indomethacin