Plasma and cerebrospinal fluid interleukin-1 beta and interleukin-6 in hospitalized schizophrenic patients.
Interleukin (IL)-1 beta and IL-6 levels in plasma and cerebrospinal fluid (CSF) of 14 medicated schizophrenic patients and 9 controls were measured by enzyme-linked immunosorbent assay. Almost no detectable levels of IL-6 in plasma or CSF from patients or controls were found. With regard to mean plasma or CSF levels of IL-1 beta there were no statistically significant differences between the two groups investigated. The dose of neuroleptic medication the patients used did not correlate with the IL-1 beta plasma levels. For the whole series of subjects (n = 23) or for the schizophrenic patients (n = 14) no correlation between the plasma and CSF levels of IL-1 beta was found.
Department of Psychiatry, Helsinki, University Central Hospital, Finland.
H
H
Katila
M
M
Hurme
K
K
Wahlbeck
B
B
Appelberg
R
R
Rimón
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000502:physiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007375:Interleukin-1 / Q000134:cerebrospinal fluid*; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000188:drug therapy / Q000276:immunology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D007375:Interleukin-1; D015850:Interleukin-6