The effect of EGb 761 on retinal lipid peroxidation and glutathione peroxidase level in experimental lens induced uveitis.
An acute lens-induced necrotizing intraocular inflammation was produced in pigmented guinea pigs. Treatment of these animals by 100 mg/kg/day EGb 761 a free oxygen radical scavenger for 10 days, reduced retinal lipid peroxidation (p > 0.05) and increased the retinal glutathione peroxidase level (p > 0.05). Although not significantly, these findings suggest that EGb 761 could be combined with other antiinflammatory drugs and may be beneficial in the treatment of uveitis.
Bilgihan
A
A
Department of Biochemistry, Gazi University, Medical Faculty, Ankara, Turkey.
Aricioğlu
A
A
Bilgihan
K
K
Onol
M
M
Hasanreisoğlu
B
B
Türközkan
N
N
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D020441:Ginkgo biloba; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006168:Guinea Pigs; D007908:Lens, Crystalline; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D014605:Uveitis / Q000188:drug therapy / Q000378:metabolism*; D000096983:Ginkgo Extract
D005979:Glutathione Peroxidase; D008315:Malondialdehyde; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract