The distribution of fasting plasma lipid concentrations in the offspring of men with premature coronary heart disease in Europe. The EARS Study.
Fasting plasma total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and total triglyceride was measured in 682 university students with a positive paternal history of coronary heart disease before the age of 55 years and 1312 age- and sex-matched controls recruited from 14 European centres. In male subjects, significant regional differences were observed for triglyceride (P < 0.005) and HDL-cholesterol (P < 0.05) but not for total or LDL-cholesterol. In female subjects, significant regional differences were observed for triglyceride (P < 0.05) and cholesterol (P < 0.05) but not for HDL- or LDL-cholesterol. Significant differences were observed between male cases and controls for cholesterol (P < 0.005) LDL-cholesterol (P < 0.005) and triglycerides (P < 0.005) but not for HDL-cholesterol. In females a significant difference was observed between cases and controls for LDL-cholesterol (P < 0.05) but not for total cholesterol, HDL-cholesterol or triglyceride.
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D003710:Demography; D005060:Europe / Q000453:epidemiology; D005215:Fasting; D005220:Fathers; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides