Prolonged penile erections induced by hydroxyzine: possible mechanism of action.
We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone metabolite, m-chlorophenylpiperazine. This suggests that a common pharmacological mechanism may underlie the ability of trazodone and hydroxyzine to induce erections.
Douglas Hospital Research Centre and Department of Chemistry, Verdun, Canada.
J X
JX
Thavundayil
R
R
Hambalek
N M
NM
Kin
B
B
Krishnan
S
S
Lal
D000328:Adult; D006801:Humans; D006919:Hydroxyzine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007299:Insect Bites and Stings / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008958:Models, Molecular; D008968:Molecular Conformation; D010879:Piperazines / Q000009:adverse effects / Q000493:pharmacokinetics; D011317:Priapism / Q000139:chemically induced*; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000493:pharmacokinetics; D013329:Structure-Activity Relationship; D014196:Trazodone / Q000009:adverse effects / Q000493:pharmacokinetics
D010879:Piperazines; D017366:Serotonin Receptor Agonists; D006919:Hydroxyzine; C015068:1-(3-chlorophenyl)piperazine; D014196:Trazodone