Axis determination. Proteolytic generation of a morphogen.
Ventral activation of a transmembrane receptor, Toll, is a crucial step in dorsoventral axis establishment in Drosophila embryos. The ventral ligand for Toll seems to be a proteolytic fragment of the Spätzle protein.
Roth
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Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544.
D000818:Animals; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D047108:Embryonic Development; D005775:Gastrula / Q000502:physiology; D005786:Gene Expression Regulation; D007301:Insect Hormones / Q000502:physiology*; D019476:Insect Proteins; D008562:Membrane Glycoproteins / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis; D011956:Receptors, Cell Surface / Q000502:physiology; D012697:Serine Endopeptidases / Q000502:physiology*; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D007301:Insect Hormones; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C086179:spz protein, Drosophila; D012697:Serine Endopeptidases; C078099:ea protein, Drosophila; C081508:snk protein, Drosophila