Urinary excretion level of hydroxylysylpyridinoline as an index of bone resorption.
Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. Urinary HP excretion levels of females were higher than those of age-adjusted males. On the other hand, the urinary excretion levels of HP in osteoporotic patients were significantly higher than those of age and sex-adjusted controls. It is suggested that the determination of urinary HP excretion levels is useful in the clinical evaluation of metabolic bone diseases, especially osteoporosis.
Tokyo College of Pharmacy, Japan.
K
K
Yoshihara
S
S
Nemoto
M
M
Nagata
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000652:urine; D000596:Amino Acids / Q000652:urine*; D001862:Bone Resorption / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D003094:Collagen / Q000378:metabolism / Q000652:urine; D003432:Cross-Linking Reagents; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000378:metabolism / Q000652:urine*; D012015:Reference Standards; D012737:Sex Factors
D000596:Amino Acids; D003432:Cross-Linking Reagents; C015484:pyridinoline; D003094:Collagen