Mucosal allergy in the absence of systemic allergy in nasal polyposis and rhinitis: a meta-analysis.
To better determine the role of allergy in rhinitis and nasal polyposis, we assessed the prevalence of nasal mucosal allergy in the absence of systemic allergy. After a thorough literature search we compiled and analyzed data from nine studies (287 patients) that tested for specific immunoglobulin E both intranasally and systemically. When meta-analysis was applied to the different populations, 19% of those who demonstrated specific immunoglobulin E manifested nasal mucosal allergy but no systemic allergy. We suggest that there is an important segment of rhinitis and nasal polyp patients who have nasal mucosal allergy.
Section of Otolaryngology, University of Chicago Hospitals, Illinois.
J S
JS
Shatkin
K G
KG
Delsupehe
R A
RA
Thisted
J P
JP
Corey
D006801:Humans; D006967:Hypersensitivity; D007073:Immunoglobulin E / Q000032:analysis*; D009297:Nasal Mucosa / Q000276:immunology*; D009298:Nasal Polyps / Q000276:immunology*; D011852:Radioallergosorbent Test; D012220:Rhinitis / Q000276:immunology*
D007073:Immunoglobulin E