[Effect of cyclosporin A on the course of the muscular phase of trichinellosis in mice].
The authors tried to determine the role of TH lymphocytes in the course of muscular trichinellosis in mice. The investigations were carried out on the CFW mice infected with 200 Trichinella spiralis larvae and treated with Cyclosporine A to suppress TH1 lymphocytes. In animals treated with the drug more numerous cells inside the larval capsules and more numerous granulomas compared to control were seen. At the same time the mean number of larvae was lower (69.2%) than in control. The results show that TH1 lymphocytes do not play the significant role in the destruction of muscular larvae. This is the first conclusion and requires of course further investigations.
Instytut Parazytologii im. Witolda Stefańskiego PAN, Wrocław.
K
K
Karmańska
M
M
Houszka
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D007814:Larva; D051379:Mice; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology*; D017160:Trichinella spiralis / Q000276:immunology; D014235:Trichinellosis / Q000276:immunology*
D016572:Cyclosporine
Wpływ cyklosporyny A na przebieg mieśniowej fazy włośnicy u myszy.