Toxocara seroprevalence in 5-year-old elementary schoolchildren: relation with allergic asthma.
Toxocara seroprevalence and the relation between Toxocara seroprevalence and allergic asthma were investigated in Dutch schoolchildren aged 4-6 years. Data on Toxocara antibodies, allergen-specific immunoglobulin E, allergic manifestations, and risk factors (pets and playgrounds) were obtained from 235 children from The Hague and 477 from Rotterdam, the Netherlands. The surveys were carried out from September 1987 to January 1988 in The Hague and in March and April 1989 in Rotterdam. Logistic regression was used to evaluate putative relations. Toxocara seroprevalence was higher in The Hague (11%) than in Rotterdam (6%), but this difference was not quite significant. Seroprevalences varied widely among schools. No differences between socioeconomic categories or between the sexes were found. Occurrences of asthma/recurrent bronchitis and hospitalization due to asthma/recurrent bronchitis were significantly associated with seroprevalence. Furthermore, a marginally significant relation with eczema was found. Immunoglobulin E specific for inhaled allergens occurred significantly more often in the Toxocara-seropositive group. The risk factors investigated were not related to seroprevalence. It is suggested that Toxocara, among other environmental factors, may stimulate polyclonally immunoglobulin E production, including allergen-specific immunoglobulin E, and thus may contribute to the manifestation of allergic asthma and possibly of eczema in children predisposed to allergy.
National Institute of Public Health and Environmental Protection, Laboratory for Parasitology and Mycology, Bilthoven, The Netherlands.
J
J
Buijs
G
G
Borsboom
J J
JJ
van Gemund
A
A
Hazebroek
P A
PA
van Dongen
F
F
van Knapen
H J
HJ
Neijens
D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D001249:Asthma / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D014119:Toxocara / Q000276:immunology; D014120:Toxocariasis / Q000453:epidemiology*
D000909:Antibodies, Helminth; D007073:Immunoglobulin E