Narrow-bore liquid chromatographic assay for oxcarbazepine and its major metabolite in rat brain, liver and blood microdialysates.
An isocratic narrow-bore high-performance liquid chromatographic assay with UV detection is described for the detection of oxcarbazepine and its major metabolite, 10,11-dihydro-10-hydroxycarbamazepine, using carbamazepine as the internal standard. This method is sufficiently sensitive to allow quantification of oxcarbazepine and its metabolite in rat brain, liver and blood microdialysates.
Van Belle
K
K
Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussels, Belgium.
De koster
V
V
Sarre
S
S
Ebinger
G
G
Michotte
Y
Y
D000818:Animals; D000927:Anticonvulsants / Q000032:analysis* / Q000097:blood; D001923:Brain Chemistry; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D002853:Chromatography, Liquid / Q000379:methods* / Q000706:statistics & numerical data; D003956:Dialysis; D008099:Liver / Q000737:chemistry*; D008297:Male; D000078330:Oxcarbazepine; D011786:Quality Control; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity
C039775:10,11-dihydro-10-hydroxycarbamazepine; D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine