[Methodologic approaches to evaluation of interaction of anti-anginal agents in their combined use in patients with exercise-induced angina].
The paper shows methodological approaches to assessing the interaction (antagonism and synergism) of antianginal agents in their combination used in 15 patients with stable angina. Each patient underwent paired bicycle ergometry with placebo, isosorbide dinitrate, 10 mg (ID), nifedipine, 20 mg (N), propranolol, 40 mg (P), and a combination of the drugs: ID, 10 mg, +P, 40 mg; N, 20 mg, +P, 40 mg; ID, 10 mg+N, 20 mg. The results were processed by two-dimensional dispersion analysis. Based on the findings, it was concluded that the interaction of drugs in all combinations was statistically insignificant in patients. At the same time the developed individual criteria for assessing the interaction allowed patients both with synergic and antagonistic interaction of antianginal drugs to be revealed.
Kukushkin
S K
SK
Vygodin
V A
VA
Kokurina
E V
EV
Metelitsa
V I
VI
Bochkareva
E V
EV
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D015444:Exercise; D006801:Humans; D007548:Isosorbide Dinitrate / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D016896:Treatment Outcome
D011433:Propranolol; D009543:Nifedipine; D007548:Isosorbide Dinitrate
Metodicheskie podkhody k otsenke vzaimodeĭstviia antianginalńykh preparatov pri ikh kombinirovannom primenenii u bolńykh so stenokardieĭ napriazheniia.