[The state of classical and alternative complement activation pathways in persons who participated in the cleanup of the aftereffects of the accident at the Chernobyl Atomic Power Plant].
The levels of T-cell activation through classical and alternative pathways were studied in persons participated in cleaning-up operations at Chernobyl N. P. P. Proliferation response of T-cells on the action of monoclonal antibody anti-CD3 (classical activation) as well as response on phytohaemagglutinin was partially decreased just as response on autologic erythrocytes in combination with phorbol 12-myristate-13 acetate (CD2-dependent alternative activation) was completely suppressed in all affected persons. Addition of interleukin 2 did not restore T-cell responses on both anti-CD3 and alternative stimulation. The different degree of decrease of T-cell responses on anti-CD3 and CD2-dependent alternative stimulation is not a result of respective alterations of cell surface CD3 and CD2 expression.
Litvina
M M
MM
Nikonova
M F
MF
Iarilin
A A
AA
D002478:Cells, Cultured; D003170:Complement Pathway, Alternative / Q000528:radiation effects*; D003171:Complement Pathway, Classical / Q000528:radiation effects*; D006801:Humans; D008213:Lymphocyte Activation / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D011210:Power Plants; D011832:Radiation Injuries / Q000276:immunology*; D018788:Radioactive Hazard Release; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014455:Ukraine
Sostoianie klassicheskogo i al'ternativnogo puteĭ aktivatsii T-limfotsitov u likvidatorov posledstviĭ avarii na ChAES.