[The efficacy of the mebendazole treatment of patients with hydatid disease].
Chemotherapy was administered to 53 patients with hydatid disease; to 27 of them it was administered to prevent recurrences. Mebendazole was prescribed by courses lasting for 14 to 30 days with intervals between the courses of 1 to 3 months, in a daily dose of 50 mg/kg to be taken 4 times. The treatment efficacy was assessed in accordance with the criteria suggested by the WHO experts. On the whole our results did not evidence any essential differences in mebendazole therapy efficacy in our patients and in those represented in a WHO report. No recurrences occurred over the period of observation, that lasted for 6 months to 6 years, in the 27 patients who were administered the drug to prevent the disease recurrences. The treatment was fairly effective in 27% of the patients, good effect was attained in 42%, no desirable results were attained in 19%, and lethal outcomes were recorded in 12% of patients.
A M
AM
Shcherbakov
E Ia
EIa
Panteleeva
R A
RA
Firsova
D004341:Drug Evaluation; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D004445:Echinococcosis, Pulmonary / Q000188:drug therapy*; D006801:Humans; D008463:Mebendazole / Q000008:administration & dosage* / Q000009:adverse effects; D012008:Recurrence; D012074:Remission Induction; D013997:Time Factors; D014944:World Health Organization
D008463:Mebendazole
Effektivnost' lecheniia bol'nykh gidatidoznym ékhinokokkozom mebendazolom.