Dose-response and risk assessment considerations for receptor-mediated effects: case study with a TCDD hepatic tumor promotion model.
Sewall
C H
CH
Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Lucier
G W
GW
D000818:Animals; D019388:Cytochrome P-450 CYP1A2; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D014453:Glucuronosyltransferase / Q000096:biosynthesis / Q000235:genetics; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008954:Models, Biological; D010088:Oxidoreductases / Q000096:biosynthesis / Q000235:genetics; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon / Q000187:drug effects / Q000502:physiology*; D018570:Risk Assessment; D015398:Signal Transduction; D013972:Thyrotropin / Q000378:metabolism
D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D013972:Thyrotropin; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D019388:Cytochrome P-450 CYP1A2; D014453:Glucuronosyltransferase; D066246:ErbB Receptors