Orthovanadate inhibits interleukin-1 and phorbol ester induced collagenase production by chondrocytes.
Conquer
J A
JA
Samuel Lunenfield Research Institute, Mount Sinai Hospital, Toronto, Canada.
Grima
D T
DT
Cruz
T F
TF
D000818:Animals; D002356:Cartilage / Q000187:drug effects / Q000201:enzymology*; D002417:Cattle; D002478:Cells, Cultured; D017364:Collagenases / Q000096:biosynthesis*; D004790:Enzyme Induction; D015870:Gene Expression / Q000187:drug effects*; D016762:Genes, fos / Q000187:drug effects; D016758:Genes, jun / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014638:Vanadates / Q000494:pharmacology*
D007375:Interleukin-1; D014638:Vanadates; D017364:Collagenases; D013755:Tetradecanoylphorbol Acetate