[The action of quaternary ammonium derivatives on respiration and nitrate reduction in Pseudomonas aeruginosa].
It was revealed that the same dosages of quaternary ammonium derivatives, such as decamethoxin and cetyltrimethylammonium bromide, inhibited the respiratory chains and caused destruction of Pseudomonas aeruginosa under aerobic conditions more effectively than under anaerobic ones when anions of nitric acid were the terminal acceptors of electrons. It was also registered that Pseudomonas were able to dissimilatory nitrate reduction in the media under the polysaccharide layer that was produced by these bacteria: this fact possibly proves the possibility of survival of denitrifying bacteria in solutions with high concentrations of quaternary ammonium salts. The data obtained permit supposing that inhibitors of respiratory chains and oxidizers may be used as potentiators of the antimicrobial action of quaternary ammonium derivatives.
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Bievskiĭ
D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology; D003650:Decamethonium Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D009566:Nitrates / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D002593:Cetrimonium Compounds; D003650:Decamethonium Compounds; D009566:Nitrates; D000644:Quaternary Ammonium Compounds; C000858:decamethoxine; D010100:Oxygen; D000077286:Cetrimonium
Deĭstvie proizvodnykh chetvertichnogo ammoniia na dykhanie i nitratreduktsiiu Pseudomonas aeruginosa.