Constructing a physical map around a constitutional t(1;13)(q22;q12) breakpoint in a patient with a ganglioneuroblastoma.
We have constructed a detailed physical map around the 13q12 region containing the constitutional chromosome translocation breakpoint from a patient with ganglioneuroblastoma. Further analysis will allow us to determine whether a gene vital for the development of sympathetic neural tissue has been disrupted by this genetic change.
Department of Haematology & Oncology, Institute of Child Health, London.
A J
AJ
Michalski
J K
JK
Cowell
D001483:Base Sequence; D002675:Child, Preschool; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D016172:DNA Fingerprinting; D017931:DNA Primers / Q000737:chemistry; D018305:Ganglioneuroblastoma / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic
D017931:DNA Primers