[Malignant atrophic papulosis].
A 53-year-old woman had noticed numerous papules on her trunk and proximal parts of the limbs. They had healed with a central scar surrounded by a reddish wall. Four months later she had to undergo laparotomy for ileus, resulting from a perforation in the region of the middle jejunum: it was excised and sutured over. At laparotomy white plaque-like lesions were noted on the serosa of both small and large intestine. Histological examination of the jejunal exudate and of a skin biopsy both demonstrated malignant atrophic papulosis (Köhlmeier-Dégos' disease). Treatment with ticlopidine, a platelet-aggregation inhibitor (250 mg twice daily), was initiated and she has now been free of extracutaneous symptoms for 6 years.
Abteilung Innere Medizin I, Marienkrankenhaus, Hamburg.
C
C
Voigt
J
J
Aumiller
W
W
Saeger
H
H
Kutzner
P C
PC
Ostendorf
D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D007416:Intestinal Perforation / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D007579:Jejunal Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D012074:Remission Induction; D012867:Skin / Q000473:pathology; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013577:Syndrome; D013988:Ticlopidine / Q000008:administration & dosage
D013988:Ticlopidine
Maligne atrophische Papulose.