Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects.
Ten male subjects were fed a diet rich in stearic acid while they were contained to a metabolic ward. There were three study periods: a 20-d baseline period followed by two 40-d intervention periods. The baseline diet contained 4.4% of energy from stearic acid; one intervention diet was high in stearic acid (7.3% of energy) and the other intervention diet was low in stearic acid (1.6% of energy). The energy contribution of protein, carbohydrate, and fat (16%, 54%, and 30%, respectively) was identical for the two diets. The fat content was distributed equally among saturated, monounsaturated, and polyunsaturated fatty acids. Urinary excretions of thromboxane B2, 2,3-dinor-thromboxane B2, 6-oxo-prostaglandin F1 alpha, and 2,3-dinor-6-oxo-prostaglandin F1 alpha were not significantly different during the two different intervention periods. This suggests that changes in dietary stearic acid do not affect in vivo thromboxane A2 or prostacyclin biosynthesis.
Blair
I A
IA
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602.
Dougherty
R M
RM
Iacono
J M
JM
D000328:Adult; D018592:Cross-Over Studies; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D015777:Eicosanoids / Q000652:urine; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013229:Stearic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000652:urine
D004041:Dietary Fats; D015777:Eicosanoids; D013229:Stearic Acids; C031183:stearic acid; D013929:Thromboxane B2; D013928:Thromboxane A2; D011464:Epoprostenol