The application of toxicokinetic data to dosage selection in toxicology studies.
Appropriate dosage selection is a key element in the design of toxicology studies and, hence, is the first step in the process of evaluating the safety of a new chemical or pharmaceutical agent. This demands careful consideration of exposure to the drug or chemical under investigation in relation to the pharmacological or toxicological effects it evokes in an experimental animal. Toxicokinetic data provide this perspective, but they should not be considered exclusively of other data which reflect the specific activity, potency, or metabolism of the drug or chemical in each individual test species. It is equally inappropriate to base dosage selection in toxicology studies exclusively on functional or morphological endpoints that cause effects outside the range which can be accommodated by homeostatic mechanisms and repair processes. Finally, extrapolation of toxicokinetic data across species lines can lead to serious miscalculations with respect to both dosage selection and the process of risk assessment. In each case, decisions should be based on the integration of toxicokinetic data with other measures and endpoints of biological and toxicological effect.
Morgan
D G
DG
Department of Toxicology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.
Kelvin
A S
AS
Kinter
L B
LB
Fish
C J
CJ
Kerns
W D
WD
Rhodes
G
G
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010599:Pharmacokinetics; D018570:Risk Assessment; D014116:Toxicology / Q000379:methods*