WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties.
WF11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899A showed good solubility in water. These three antibiotics possess potent in vitro antifungal activities against Candida spp.
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
T
T
Iwamoto
A
A
Fujie
K
K
Sakamoto
Y
Y
Tsurumi
N
N
Shigematsu
M
M
Yamashita
S
S
Hashimoto
M
M
Okuhara
M
M
Kohsaka
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D005285:Fermentation; D055666:Lipopeptides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism / Q000648:ultrastructure; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D012995:Solubility
D000935:Antifungal Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; C090474:WF 11899A; C090476:WF 11899C