Antiviral activity of new triterpenic derivatives.
Twenty-seven triterpenic derivatives of glycyrrhetinic, oleanolic, ursolic and maslinic acid were tested for antiviral and cytotoxic properties. Twelve of them showed apparent antiviral activity against at least one of the tested viruses. The most active compounds were PAS-T45 and 48 which exerted a protection index of 4 on vaccinia virus.
Serra
C
C
Sezione di Microbiologia Medica, Istituto di Medicina Interna, Facolità di Medicina e Chirurgia, Cagliari, Italy.
Lampis
G
G
Pompei
R
R
Pinza
M
M
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000494:pharmacology*
D000998:Antiviral Agents; D014315:Triterpenes