The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.
The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.
Cardiovascular Research Institute, University of California at San Francisco (UCSF) 94143-0130.
S
S
Werner
H
H
Smola
X
X
Liao
M T
MT
Longaker
T
T
Krieg
P H
PH
Hofschneider
L T
LT
Williams
D000375:Aging; D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D004817:Epidermis / Q000473:pathology; D004847:Epithelial Cells; D051526:Fibroblast Growth Factor 10; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000502:physiology*; D006197:Hair / Q000166:cytology / Q000254:growth & development; D015603:Keratinocytes / Q000166:cytology* / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D012867:Skin / Q000166:cytology*; D014945:Wound Healing / Q000502:physiology*
C496454:Fgf7 protein, mouse; D051526:Fibroblast Growth Factor 10; D006133:Growth Substances; D017468:Receptors, Fibroblast Growth Factor; D017978:Receptors, Growth Factor; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D051497:Receptor, Fibroblast Growth Factor, Type 2; C065104:keratinocyte growth factor receptor