Calcitonin-secreting ovarian strumal carcinoid.
A 3-mm strumal carcinoid was found incidentally in a mature ovarian cystic teratoma of a 38-year-old woman followed up for more than 9 years. Although the thyroid component disclosed a typical normal light microscopic appearance, no thyroglobulin and thyroxine were detected immunohistochemically. Immunoreactive calcitonin was demonstrated within the tumour cells. The close relationship between functionally imperfect thyroid tissue and a neuroendocrine marker-secreting tumour seems to be concordant with the theory of the existence of a pluripotential stem cell capable of differentiating multidirectionally.
Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary.
O
O
Esik
G
G
Németh
K
K
Szepesházi
D000328:Adult; D002116:Calcitonin / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D013330:Struma Ovarii / Q000378:metabolism* / Q000473:pathology; D013724:Teratoma / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology
D002116:Calcitonin