[A prospective histologic and immunohistochemical study of the liver in blood donors who are asymptomatic chronic carriers of HBs antigens. Apropos of 34 cases].
The authors report a prospective study of 34 chronic HBs Ag carriers detected among a cohort of 9029 blood donors. Liver biopsy performed in all cases revealed a normal liver in 5 cases (14.7%), non-specific lesions in the form of fatty infiltration or mild portal inflammation in 3 cases (8.8%), chronic persistent hepatitis (CPH) in 21 cases (61.7%) (mild in 19 and moderate in 2) and chronic active hepatitis (CAH) in 5 cases (14.6%) (mild in 1 and moderate in 4). Liver function tests were abnormal in 28.8% of patients with CPH and 20% of those with CAH. Histologic activity index was calculated and was more than 6 in 40% of CAH and 6 or less in CPH and non-specific lesions. Immunohistochemical study revealed cytoplasmic labelling for HBs Ag in 82.4 per cent of cases and nuclear labelling for HBc Ag in 11.4% of cases with a heterogeneous and non-regular pattern affecting all or part of the cytoplasm, single or clusters of hepatocytes or even sheets of hepatocytes.
Service d'Anatomie et de Cytologie pathologique, Hôpital militaire de Tunis, Montfleury, Tunisie.
A
A
Ben Rejeb
F
F
Khediri
N
N
Ebdelli
R
R
Bouali
F
F
Ben Ahmed
D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D001782:Blood Donors; D002353:Carrier State; D015331:Cohort Studies; D003593:Cytoplasm / Q000276:immunology; D005234:Fatty Liver / Q000276:immunology / Q000473:pathology; D006505:Hepatitis / Q000276:immunology / Q000473:pathology; D006509:Hepatitis B / Q000276:immunology* / Q000473:pathology*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000097:blood; D006521:Hepatitis, Chronic / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000201:enzymology / Q000276:immunology* / Q000473:pathology*; D008297:Male; D011446:Prospective Studies
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Etude histologique et immuno-histochimique prospective du foie chez des donneurs de sang porteurs chroniques asymptomatiques de l'antigène HBs. A propos de 34 cas.