Urinary melatonin excretion throughout the ovarian cycle in menstrually related migraine.
Nocturnal urinary melatonin excretion was significantly decreased throughout an ovarian cycle in 12 migraine without aura patients compared to 8 healthy controls. Normal increases in urinary melatonin excretion during the luteal phase was less pronounced in the migraine patients. Melatonin excretion was further decreased during headache. The data indicate impaired pineal function in migraine.
Department of Endocrinological and Metabolic Sciences, University of Genoa, Italy.
G
G
Murialdo
S
S
Fonzi
P
P
Costelli
G P
GP
Solinas
C
C
Parodi
S
S
Marabini
M
M
Fanciullacci
A
A
Polleri
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000502:physiology; D008550:Melatonin / Q000652:urine*; D008597:Menstrual Cycle / Q000502:physiology*; D008599:Menstruation Disturbances / Q000175:diagnosis / Q000652:urine*; D008881:Migraine Disorders / Q000175:diagnosis / Q000652:urine*; D010870:Pineal Gland / Q000502:physiology
D008550:Melatonin