Cardiac amyloidoma with IgM-kappa gammopathy.
A 73-year-old man presented with dyspnea and atrial flutter associated with an amyloid tumor in the heart. IgM-kappa gammopathy, hypercalcemia, and extensive cardiac and mediastinal invasion suggested a malignant lymphoid or plasma cell process. Although amyloidoma is generally considered to be a benign tumor, the aggressive features of this case mandated chemotherapy because the critical location rendered the tumor inoperable. This case provides noteworthy evidence in support of a possible pathogenic relationship between amyloidoma and plasmacytoma by virtue of dual representative features: localized amyloid infiltrated with plasma cells and the associated gammopathy. Local and systemic malignant features lend additional support to this hypothesis.
Department of Pathology, University of Alabama at Birmingham 35294-3300.
K J
KJ
Warner
G G
GG
Blackwell
G A
GA
Herrera
C
C
Listinsky
W L
WL
Holman
P K
PK
Rustagi
D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D006338:Heart Neoplasms / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D008297:Male; D009206:Myocardium / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D010954:Plasmacytoma / Q000175:diagnosis / Q000473:pathology
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains