Ultrastructural alterations of Golgi apparatus in the nerve cells of cerebral cortex in human hydrocephalus. A qualitative study using cortical biopsies.
Cortical biopsies of 17 patients with clinical diagnosis of hydrocephalus and associated pathology were examined in the transmission electron microscope. Moderately and severely edematous neurons showed relevant structural changes of the Golgi apparatus consisting of either discrete or marked dilation, fragmentation, and partial disappearance of Golgi stacked cisternae. In Arnold-Chiari malformation small Golgi complexes of vesicular type and atrophic changes were observed in severely edematous neurons. The microtubules appeared intact, suggesting differential response between Golgi complex and microtubules. Atrophic changes of the Golgi complex coexisted with degenerated presynaptic endings.
Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
O J
OJ
Castejon
M
M
Diaz
C
C
Valero
D000328:Adult; D001706:Biopsy; D002540:Cerebral Cortex / Q000648:ultrastructure*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure*; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009474:Neurons / Q000648:ultrastructure*