N-glucuronidation reactions. III. Regioselectivity of N-glucuronidation of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole using human and rat recombinant UDP-glucuronosyltransferases stably expressed in V79 cells.
Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ 07065.
S E
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Huskey
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Magdalou
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Ouzzine
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Siest
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Chiu
D000818:Animals; D001713:Biphenyl Compounds / Q000378:metabolism*; D002460:Cell Line; D004795:Enzyme Stability; D005347:Fibroblasts / Q000201:enzymology; D005965:Glucuronates / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D007536:Isomerism; D008168:Lung / Q000166:cytology / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity; D013777:Tetrazoles / Q000378:metabolism*; D014230:Triazoles / Q000378:metabolism*
D001713:Biphenyl Compounds; D005965:Glucuronates; D007093:Imidazoles; D007527:Isoenzymes; D011994:Recombinant Proteins; D013777:Tetrazoles; D014230:Triazoles; D014453:Glucuronosyltransferase