Blood-damaged tissue interaction in experimental brain ischemia.
This paper is a review and synthesis of work done in our laboratory by many investigators over roughly 18 years dealing with the microcirculation in a zone of acute ischemic injury. The work has been guided by a hypothesis that blood flowing through the microcirculation of an acute injury zone is capable of undergoing a multifactorial interaction at the blood-endothelial interface that can progressively impair microvascular perfusion and contribute locally to the evolution of cellular damage and death. Our work has implicated Factor VIII/von Willebrand factor, prostanoids, leukocytes, platelets, platelet-activating factor, leukotrienes, adhesion receptors, monocytes/macrophages, and cytokines in this interaction.
Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
J M
JM
Hallenbeck
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000503:physiopathology*; D002470:Cell Survival / Q000502:physiology; D004285:Dogs; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005169:Factor VIII / Q000502:physiology; D007511:Ischemia / Q000503:physiopathology; D015289:Leukotrienes / Q000502:physiology; D008833:Microcirculation / Q000503:physiopathology; D009410:Nerve Degeneration / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D011817:Rabbits; D013116:Spinal Cord / Q000098:blood supply; D014841:von Willebrand Factor / Q000502:physiology
D015289:Leukotrienes; D010972:Platelet Activating Factor; D011453:Prostaglandins; D014841:von Willebrand Factor; D005169:Factor VIII