Screening for non-polyenic antifungal antibiotics produced by rare Actinomycetales.
Strains of Actinomycetales (286 in toto) belonging to thirteen genera other than Streptomyces were isolated from different ecosystems in the Algerian Sahara. Among these strains, 32 showed antibiotic activity against at least one of the test organisms comprising four bacteria, two yeasts and several filamentous fungi, and twelve were antagonistic against both bacteria and fungi. The characteristic UV spectra of active extracts revealed that six strains produced non-polyenic antifungal substances and four synthetized polyenic substances. One strain of Spirillospora produced a pentaene antifungal substance. The only antibiotic so far known to be produced by this genus is spirillomycin.
Unité de Recherche sur les Zones Arides, Université des Sciences et de la Technologie, Algeria.
H
H
Hacène
N
N
Sabaou
N
N
Bounaga
G
G
Lefebvre
D000192:Actinomycetales / Q000302:isolation & purification / Q000378:metabolism*; D000352:Africa, Northern; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012988:Soil Microbiology; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D014871:Water Microbiology; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents