[Effects of nifedipine on hepatic hyaluronic acid, hydroxyproline and glucosaminidase contents in rats with liver fibrosis].
In early stage treatment groups, Nifedipine (Nif) could significantly reduce hepatic hyaluronic acid (HA) and hydroxyproline (Hyp) contents in rats in which liver fibrosis had been induced by CCl4 treatment. N-acetyl-beta-glucosaminidase (beta-NAG) activity showed a similar change in the high dosage group. In late stage treatment groups, HA was reduced markedly, and decreased beta-NAG levels were noted in the high dosage group. These effects on HA, Hyp and beta-NAG were dependent on Nif dosage. The results suggest that Nif could inhibit the development of liver fibrosis in rats, and may even reverse it.
Xin Hua Hospital, Shanghai Second Medical University.
J
J
Che
H
H
Lu
D
D
Li
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D004305:Dose-Response Relationship, Drug; D006909:Hydroxyproline / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000118:Acetylglucosaminidase; D009543:Nifedipine; D006909:Hydroxyproline