In vivo differentiation of edematous changes after stroke in spontaneously hypertensive rats using diffusion weighted MRI.
Apparent diffusion coefficients (ADCs) of tissue water were determined in chronic brain lesions of a rat stroke model, the stroke-prone spontaneously hypertensive rat, and compared with histology. ADCs increased in the order normal < edema < gliosis < cyst. The differences between individual groups were statistically significant. The increase in ADC is thought to mainly reflect a relative increase in the extracellular space in brain tissue. ADC may be a new parameter for tissue characterization.
Research Department, Nihon Schering, Japan.
M
M
Takahashi
B
B
Fritz-Zieroth
T
T
Chikugo
H
H
Ogawa
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001929:Brain Edema / Q000473:pathology / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology*; D003560:Cysts / Q000473:pathology / Q000503:physiopathology; D004058:Diffusion; D005110:Extracellular Space / Q000502:physiology; D005911:Gliosis / Q000473:pathology / Q000503:physiopathology; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D014882:Water-Electrolyte Balance / Q000502:physiology*