Effects of lithium on bone resorption in cultured foetal rat long-bones.
Increased serum calcium has been observed in manic depressive patients treated with lithium (Li), and one of the mechanisms increasing serum calcium could be a sensitizing effect of Li on bone resorption. In a previous study, however, Li has been found slightly to inhibit PTH-stimulated resorption in cultured foetal rat long-bones. In this work, we extended the study of the effects of Li on bone resorption in culture when resorption of foetal rat long-bones was stimulated by factors other than PTH. Li 3 mM had no effect on basal resorption, a slight and inconsistent inhibitory effect on PTH stimulated bone resorption, a moderate and inconstant inhibitory effect on prostaglandin E2 (PGE2) stimulated resorption, and did not significantly affect the enhancement of resorption by interleukin 1 (IL1). The more constant effect of Li was a nearly complete inhibition of the resorption response to 1,25-dihydroxycholecalciferol (1,25(OH)2D3). This study confirms that Li has no stimulatory effect on bone resorption by itself, nor a sensitizing action on the stimulation of resorption by several activators. Conversely, Li has a striking inhibitory effect on bone resorption stimulated by 1,25(OH)2D3.
Pepersack
T
T
Department of Internal Medicine, Université Libre de Bruxelles, Belgium.
Corvilain
J
J
Bergmann
P
P
D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology*; D002117:Calcitriol / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005333:Fetus; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D007700:Kinetics; D018021:Lithium Chloride / Q000494:pharmacology*; D009924:Organ Culture Techniques; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D019379:Teriparatide; D013997:Time Factors
D007375:Interleukin-1; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011994:Recombinant Proteins; D019379:Teriparatide; D000242:Cyclic AMP; D002117:Calcitriol; D018021:Lithium Chloride; D015232:Dinoprostone