[The efficacy of antibacterial preparations against Pseudomonas mallei in in-vitro and in-vivo experiments].
In vitro antibacterial activity of 43 antibiotics and chemotherapeutics against P. mallei Ts-5 was studied. The causative agent of malleus was highly susceptible to sulfanilamides, fluoroquinolones, tetracyclines, aminoglycosides, ceftazidime and imipenem. 15 antibiotics and chemotherapeutics were tested for their therapeutic efficacy on golden hamsters with experimental malleus. Combinations with trimetoprim (sulfaton and biseptol), 3rd generation quinolones (ciprofloxacin, enoxacin and ofloxacin) as well as minocycline, novobiocin and oxolinic acid were shown to be therapeutically highly efficient.
I N
IN
Manzeniuk
V V
VV
Dorokhin
E A
EA
Svetoch
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005896:Glanders / Q000188:drug therapy* / Q000517:prevention & control; D008647:Mesocricetus; D008826:Microbial Sensitivity Tests / Q000379:methods; D011549:Pseudomonas / Q000187:drug effects*
D000900:Anti-Bacterial Agents
Effektivnost' antibakterial'nykh preparatov v otnoshenii Pseudomonas mallei v opytakh in vitro i in vivo.