Metabolic changes following cortical contusion: relationships to edema and morphological changes.
Rats with contusion injury to the right cortex exhibited significant formation of edema 6 and 24 hours after injury which resolved by 8 days and was replaced by cavitation necrosis. The contusions produced hyperglycolysis and ischemia in the impacted cortical tissue and underlying hippocampus immediately through 30 minutes post-injury. Glucose utilization was depressed throughout the contused cortex and in ipsilateral subcortical regions, as was blood flow, at chronic (1 and 10 days) periods after injury.
Division of Neurosurgery, University of New Mexico, Albuquerque.
R L
RL
Sutton
D A
DA
Hovda
P D
PD
Adelson
E C
EC
Benzel
D P
DP
Becker
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001924:Brain Concussion / Q000473:pathology / Q000503:physiopathology*; D001929:Brain Edema / Q000473:pathology / Q000503:physiopathology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000502:physiology
D001786:Blood Glucose