Influence of gadolinium chelates on phosphorus-31 magnetic resonance spectroscopy of the liver.
OBJECTIVE
The potential of gadolinium compounds (Gd-ethoxybenzyl-DTPA [Gd-EOB-DTPA], gadopentetate dimeglumine [Gd-DTPA], and Gd-chloride [GdCl3]) to enhance the signals from intracellular phosphorus-31 nuclei in the liver was investigated.


METHODS
After intravenous administration of Gd-EOB-DTPA, Gd-DTPA, and GdCl3 to rats, liver phosphorus metabolites (inorganic phosphate [Pi], phosphomonoester [PME], and adenosine triphosphate [ATP]) were measured by phosphorus-31 magnetic resonance spectroscopy (MRS). The dose of each compound was 0.2 mmol Gd/kg. Saline was used as a control.


RESULTS
The intensities of the phosphorus metabolite signals in the liver showed only minor changes after administration of Gd-DTPA and GdCl3, but increased after Gd-EOB-DTPA. The signals of Pi and PME were enhanced more than those of ATP. The alpha peak of ATP increased by 21.7%, Pi by 61.2%, and PME by 49.2%.


CONCLUSIONS
The signal intensities of the phosphorus metabolites in the liver were not influenced by GdCl3. Using Gd-DTPA, only a slight enhancement could be detected. The greatest enhancement was observed with Gd-EOB-DTPA, which has access to the phosphorus metabolites within the hepatocytes. The injection of Gd-EOB-DTPA results in better detectability of the Pi signal.
Research Laboratories, Schering AG Berlin, Germany.
H
H
Bauer
C
C
Negishi
H J
HJ
Weinmann
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D003287:Contrast Media; D009942:Organometallic Compounds; D010710:Phosphates; C073590:gadolinium ethoxybenzyl DTPA; D010725:Phosphocreatine; D004369:Pentetic Acid; D000255:Adenosine Triphosphate; D005682:Gadolinium; D019786:Gadolinium DTPA; C038958:gadolinium chloride