Effect of corticosteroid treatment on salicylate ototoxicity.
Our previous studies showed that salicylate ototoxicity is associated with decreased levels of prostaglandins (PGs) and elevated levels of leukotrienes (LTs) in the perilymph. The purpose of this study was to determine whether or not pretreatment with corticosteroid, which suppresses both PGs and LTs in arachidonic acid metabolism, prevents salicylate ototoxicity. Salicylate ototoxicity was induced in chinchillas with or without treatment with dexamethasone. Hearing thresholds were measured by auditory brain stem response, and perilymph samples were assayed by high-performance liquid chromatography. Dexamethasone pretreatment, given by either systemic or local round window membrane application, partially prevented salicylate-induced hearing loss. Prevention of salicylate ototoxicity by dexamethasone seems to be correlated with increased PG levels and decreased LT levels in the perilymph. This is another piece of evidence that salicylate ototoxicity may be mediated by abnormal arachidonic acid metabolism in the inner ear.
Division of Otolaryngology-Head and Neck Surgery, Loma Linda University School of Medicine, California.
Y S
YS
Park
T T
TT
Jung
D J
DJ
Choi
C K
CK
Rhee
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002682:Chinchilla; D003907:Dexamethasone / Q000627:therapeutic use*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006311:Hearing Disorders / Q000139:chemically induced* / Q000188:drug therapy* / Q000517:prevention & control; D015289:Leukotrienes / Q000378:metabolism; D010498:Perilymph / Q000378:metabolism; D012684:Sensory Thresholds / Q000187:drug effects; D012980:Sodium Salicylate / Q000009:adverse effects*
D015289:Leukotrienes; D016718:Arachidonic Acid; D015121:6-Ketoprostaglandin F1 alpha; D003907:Dexamethasone; D012980:Sodium Salicylate