Alterations of metal content in the kidneys of puromycin aminonucleoside-administered rats.
To explore the mechanism responsible for puromycin aminonucleoside induced-nephrotoxicity, metal content was preliminarily investigated in the kidneys of rats that had received a single subcutaneous injection of the agent (80 mg/kg body weight). In the group that received this agent, the renal content of Fe rose on days 5, 10, and 15; that of Cu fell on days 10 and 15; that of Zn rose on day 5; that of Se fell on day 10; there were no changes in Mn throughout the experimental period. Providing that these findings directly involved the renal activities of superoxide dismutases and glutathione peroxidase, the renal reduction of Cu and Se gave proof counter to previous findings of an enzymatic protective system against possible attacks by the oxygen radicals.
Department of Clinical Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
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M
Fukata
T
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Hayashi
J
J
Terui
J
J
Sudo
D000704:Analysis of Variance; D000818:Animals; D003300:Copper / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007279:Injections, Subcutaneous; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D011692:Puromycin Aminonucleoside / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D012643:Selenium / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D008670:Metals; D017382:Reactive Oxygen Species; D008345:Manganese; D011692:Puromycin Aminonucleoside; D003300:Copper; D007501:Iron; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D015032:Zinc