Single beat evaluation of circumferential aortic elastin elastic modulus in conscious dogs. Potential application in non-invasive measurements.
A description of the arterial wall elastic properties comprehends both collagen and elastin, clearly shown in a biphasic stress-strain relationship. From chronically instrumented conscious dogs, aortic pressure-diameter curves can be obtained in a single beat, which is impossible to perform in human beings. In control conditions, the collagen fibers are almost not distended and the resistance to stretch is mainly supported by the elastin fibers. Therefore, the mechanical properties of the aorta are almost purely elastic in the basal beat to beat conditions. In this study we propose and test five indexes, which include as variables: systolic, diastolic and mean arterial pressure and diameter; besides, arterial compliance and pressure-strain elastic modulus as suggested to evaluate the elastic behaviour of the elastic fibers. This data can be easily obtained by non-invasive methods, such as Doppler-ultrasound techniques and auscultative esphygmomanometrical measurements, while the indexes evaluated can be retrieved from a single beat evaluation. Of three measurements performed in chronically instrumented conscious dogs on different days, one of these indexes, the ME5 = [formula: see text] x Rdias proved to be an accurate and reliable parameter to evaluate the mechanical behaviour of arteries. This kind of parameter may be useful for research and evaluation of several diseases that markedly alter the arterial wall compliance.
Basic Sciences Research Center, University Institute of Biomedical Sciences, Favaloro Foundation, Buenos Aires, Argentina.
R L
RL
Armentano
E I
EI
Cabrera Fischer
J G
JG
Barra
J A
JA
Levenson
A C
AC
Simon
R H
RH
Pichel
D000465:Algorithms; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure; D003094:Collagen / Q000502:physiology; D003971:Diastole / Q000502:physiology; D004285:Dogs; D004548:Elasticity; D004549:Elastin / Q000502:physiology; D008297:Male; D008955:Models, Cardiovascular; D012044:Regression Analysis; D012815:Signal Processing, Computer-Assisted; D013314:Stress, Mechanical; D013599:Systole / Q000502:physiology
D003094:Collagen; D004549:Elastin