The LIM domain: a new structural motif found in zinc-finger-like proteins.
An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
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Sánchez-García
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Rabbitts
D000595:Amino Acid Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D011506:Proteins