[Serum levels of thymus hormones and autoantibodies to the thymus epithelium in inhabitants of regions contaminated with radionuclides].
Increased level of serum thymic activity and normal serum concentration of alpha-1-thymosin were revealed in inhabitants of region polluted by radionuclides after Chernobyl accident (settlement Vyshkov, Bryansk region). In the same population the serum level of autoantibodies, reacting with thymic epithelial cell line was elevated. Similar but less prominent alterations were found in population of radiologically pure region (settlement Potchep). Revealed autoantibodies had mainly IgM isotype. The negative correlation exists between levels of autoantibodies and serum thymic activity. Sera of persons from the control group and one half of Vyshkov inhabitants reacted with thymic epithelial cells of both human and mouse origin; in other half of Vyshkov inhabitants species-specific autoantibodies were revealed. We propose that correlated increase of antithymic autoantibody level and decrease of serum thymic activity are the consequence and indicators of unfavorable ecological conditions; however the contribution of radiation factor to their induction can not be estimated on the basis of presented data.
Iarilin
A A
AA
Sharova
N I
NI
Kuz'menok
O I
OI
Titova
L D
LD
Kotina
N I
NI
Oradovskaia
I V
IV
D001323:Autoantibodies / Q000097:blood*; D004848:Epithelium / Q000276:immunology; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate; D006801:Humans; D011210:Power Plants; D011834:Radiation Monitoring; D018788:Radioactive Hazard Release; D011848:Radioactive Pollutants / Q000633:toxicity*; D013950:Thymus Gland / Q000276:immunology*; D013951:Thymus Hormones / Q000097:blood*; D014455:Ukraine
D001323:Autoantibodies; D011848:Radioactive Pollutants; D013951:Thymus Hormones; D016650:Fluorescein-5-isothiocyanate
Soderzhanie gormonov timusa i autoantitel k épiteliiu timusa v syvorotke krovi zhiteleĭ raĭonov, zagriaznennykh radionuklidami.