Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors.
We aimed to determine whether levels of plasma fatty acids are correlated with other potential risk factors for cardiovascular disease, using a sample of patients from a cross-sectional survey of the general population, in the City of Edinburgh. 306 men and women aged 55-74 years of whom half had clinical evidence of arterial disease were tested. The main outcome measures were plasma fatty acids and potential risk factors for cardiovascular disease (age, sex, smoking, blood pressure, serum cholesterol, HDL cholesterol (HDL-C), triglycerides (TGs), lipid peroxides (LPx), plasma fibrinogen, von-Willebrand factor (vWf), beta-thromboglobulin (beta TG), cross-linked fibrin degradation products (FIBDP) and plasminogen activator inhibitor PAI). High levels of several known risk factors for cardiovascular diseases were associated with low levels of certain essential fatty acids. Eicosapentaenoic (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) were negatively associated with smoking and TG levels. High levels of certain haemostatic factors, including plasma fibrinogen, blood viscosity and LPx were also associated with low levels of EPA, DHA, AA and HDL-C. In conclusion, plasma fatty acids show strong correlations with many potential risk factors for cardiovascular disease, emphasising their possible importance in pathogenesis.
Leng
G C
GC
Wolfson Unit for Prevention for Peripheral Vascular Diseases, Department of Public Health Sciences, University of Edinburgh, UK.
Smith
F B
FB
Fowkes
F G
FG
Horrobin
D F
DF
Ells
K
K
Morse-Fisher
N
N
Lowe
G D
GD
D000368:Aged; D016718:Arachidonic Acid / Q000097:blood; D001794:Blood Pressure; D001809:Blood Viscosity; D002318:Cardiovascular Diseases; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D005228:Fatty Acids, Essential / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D012212:Rheology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014280:Triglycerides / Q000097:blood
D005228:Fatty Acids, Essential; D008054:Lipid Peroxides; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D005340:Fibrinogen; D015118:Eicosapentaenoic Acid