Reciprocal translocation t(12;13)(p13;q14) in acute nonlymphoblastic leukemia: report and cytogenetic analysis of two cases.
Two cases of acute nonlymphoblastic leukemia with a reciprocal translocation t(12;13)(p13;q14) are described. Both patients were male adults with a diagnosis of M0 FAB type. Beside standard cytogenetic analysis, we applied fluorescence in situ hybridization (FISH) in order to investigate the position of the RB gene with respect to the breakpoint at 13q14. Our results showed that the RB gene was proximal to the breakpoint, but, apparently, not split in either case.
Clinica Pediatrica, Università di Milano, Italy.
S
S
Tosi
S
S
Stilgenbauer
G
G
Giudici
S
S
Capalbo
G
G
Specchia
V
V
Liso
S
S
Castagna
E
E
Lanzi
P
P
Lichter
A
A
Biondi
D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic