2-Diphenylmethylsilylethyl (DPSE): a versatile protecting group for oligodeoxyribonucleotide synthesis.
2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for the internucleotidic bonds in the solid-support and solution-phase synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable under acidic conditions and can be removed by a beta-fragmentation mechanism under mild conditions using aqueous NH4OH. Alternatively, this group can also be removed using tetrafluorosilane in acetonitrile.
Ravikumar
V T
VT
Isis Pharmaceuticals, Carlsbad, CA 92008.
Cole
D L
DL
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis; D017646:Organosilicon Compounds / Q000737:chemistry*; D012996:Solutions
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009943:Organophosphorus Compounds; D017646:Organosilicon Compounds; D012996:Solutions