Modulation of epithelial cell growth by intraepithelial gamma delta T cells.
The role played in immune surveillance by gamma delta T cells residing in various epithelia has not been clear. It is shown here that activated gamma delta T cells obtained from skin and intestine express the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial alpha beta T cells, as well as all lymphoid alpha beta and gamma delta T cell populations tested, did not produce KGF or promote the growth of cultured epithelial cells. These results suggest that intraepithelial gamma delta T cells function in surveillance and in repair of damaged epithelial tissues.
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
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D000818:Animals; D001483:Base Sequence; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D003001:Cloning, Molecular; D003713:Dendritic Cells / Q000502:physiology*; D004847:Epithelial Cells; D051526:Fibroblast Growth Factor 10; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000096:biosynthesis* / Q000235:genetics; D015603:Keratinocytes / Q000166:cytology*; D008213:Lymphocyte Activation; D051379:Mice; D008969:Molecular Sequence Data; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
C496454:Fgf7 protein, mouse; D051526:Fibroblast Growth Factor 10; D006133:Growth Substances; D016692:Receptors, Antigen, T-Cell, gamma-delta; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors