Nephrogenic diabetes insipidus secondary to lithium therapy in the postoperative patient: a case report.
Nephrogenic diabetes insipidus (NDI) presents a rarely encountered but challenging fluid management problem in the perioperative period. This case is that of a patient with a perforated duodenal ulcer and previously undiagnosed NDI who received standard preoperative and postoperative hydration with normal saline, causing hypernatremia and an inappropriate diuresis. The resulting hypernatremia and hyperosmolality required aggressive hypotonic fluid replacement to return to preoperative values. Though refractory to 1-desamino-8-D-argenine-vasopressin (dDAVP), thiazide diuretics and nonsteroidal anti-inflammatory agents have a role in managing selected patients. Early diagnosis with careful fluid and electrolyte management are critical in successful management of these patients in the perioperative period.
Department of General Surgery, Keesler Medical Center, Keesler Air Force Base, Mississippi.
M A
MA
Johnson
J
J
Ogorman
G H
GH
Golembiewski
M W
MW
Paluzzi
D000328:Adult; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000503:physiopathology*; D004231:Diuresis; D004381:Duodenal Ulcer / Q000601:surgery; D005440:Fluid Therapy / Q000009:adverse effects*; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009994:Osmolar Concentration; D010439:Peptic Ulcer Perforation / Q000601:surgery; D011183:Postoperative Complications; D012964:Sodium / Q000097:blood / Q000652:urine
D008094:Lithium; D012964:Sodium