Effect of sodium chloride supplementation on urinary endothelin-1 excretion in premature infants.
We investigated the role of endothelin-1 in the renal adaptation to alterations in sodium balance in premature infants. The postnatal course of urinary endothelin-1 excretion, an estimate of renal endothelin-1 production, was compared in premature infants receiving low or high sodium intake. Sodium supplementation was given in a dose of 3 to 5 mmol/kg per day and 1.5 to 2.5 mmol/kg per day at the postnatal ages of 8 to 21 and 22 to 35 days, respectively. Sodium balance and urinary endothelin-1 excretion were determined weekly up to the fifth week of life. Urinary endothelin-1 concentration (expressed in picomoles per liter) and urinary endothelin-1 excretion (expressed either in terms of picomoles per square meter per day or picomoles per millimole creatinine) were significantly lower in infants receiving a high sodium intake compared with those receiving low sodium intake (p < 0.001) in weeks 2 through 5. We conclude that in sodium-depleted premature infants with high urinary sodium excretion, an angiotensin II-mediated increase in renal endothelin-1 production occurs, which acts in concert with angiotensin II to restore sodium balance.
County Children's Hospital, Pécs, Hungary.
W
W
Rascher
G
G
Gyódi
S
S
Worgall
E
E
Sulyok
D016232:Endothelins / Q000097:blood / Q000187:drug effects / Q000652:urine*; D005527:Food, Fortified; D006801:Humans; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology* / Q000652:urine; D008297:Male; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D016232:Endothelins; D017673:Sodium Chloride, Dietary