Intravascular papillary endothelial hyperplasia of the oral soft tissues: report of 18 cases and review of the literature.
OBJECTIVE
Intravascular papillary endothelial hyperplasia (IPEH) is a benign, nonneoplastic, vascular lesion, that is characterized histologically by papillary fronds lined by proliferating endothelium: it is thought to represent an unusual form of organizing thrombus. It may develop in a distended vessel or in association with other vascular lesions. The main significance of IPEH is its microscopic resemblance to angiosarcoma and possible misinterpretation as such.


METHODS
We report the clinicopathologic features of 18 examples of IPEH of the oral soft tissues and lips, and review such features of 55 previously reported oral cases.


RESULTS
The lips and tongue were most frequently involved and a female predilection was evident. Histologically, the pure form of IPEH was more commonly encountered.


CONCLUSIONS
The differential diagnosis and possible histogenesis of the lesion are discussed.
Department of Oral Pathology and Surgery, Faculty of Dentistry, University of Athens, Greece.
K
K
Tosios
I G
IG
Koutlas
S I
SI
Papanicolaou
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006390:Hemangioendothelioma / Q000175:diagnosis; D006391:Hemangioma / Q000175:diagnosis*; D006801:Humans; D006965:Hyperplasia; D008046:Lip / Q000098:blood supply; D008048:Lip Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012744:Sex Ratio; D014059:Tongue / Q000098:blood supply; D014062:Tongue Neoplasms / Q000175:diagnosis*