Growth characteristics of early passage cell lines compared with established TCC bladder lines.
The growth patterns of established cell lines from bladder transitional cell carcinoma (TCC) were compared with early passage cell lines. The growth of established cell line 5637 was uninhibited in both serum free (basal) and serum containing media. The early passage line (DR) grew only in serum containing medium. This confirms the unreliability of results from biological studies on established (continuous) cell lines.
Nargund
V H
VH
Cancer Medicine Research Unit, University of Bradford, West Yorkshire, UK.
Barker
I K
IK
Coombs
L
L
Flannigan
G M
GM
Stewart
P A
PA
Crawford
S M
SM
D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D002455:Cell Division; D003584:Cytological Techniques; D006801:Humans; D013997:Time Factors; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms / Q000473:pathology*