Monitoring multi-armed trials.
We propose and discuss several methods of monitoring multi-armed trials comparing means or survival. These methods combine multiple comparison procedures such as Fisher's LSD, Newman-Keuls and Tukey's with monitoring boundaries such as those of O'Brien and Fleming and Lan and DeMets. Tables of boundaries are provided for the equal variance or equal censoring distribution case.
Proschan
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MA
National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.
Follmann
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DA
Geller
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NL
D015982:Bias; D003627:Data Interpretation, Statistical; D006801:Humans; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D016019:Survival Analysis; D016896:Treatment Outcome