[A position effect variegation model of chromatin compaction].
A position effect variegation (PEV) model of chromatin compaction is proposed, based on the concept of a statistical distribution of compaction protein (CP) molecules around compaction initiation centers (CICs). The principles of the model are as follows: (1) CICs are present in both hetero- and euchromatin, and (2) different CP molecules interact not only with DNA but also with one another, forming a multimeric complex. When a certain level of DNA-protein binding is exceeded, heterochromatic domains are formed. The model suggests that continuous and discontinuous chromatin compaction resulting from PEV is due to an irregular CIC distribution along the chromosome.
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ML
Balasov
I V
IV
Makunin
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D008957:Models, Genetic; D009030:Mosaicism
D002843:Chromatin; D004268:DNA-Binding Proteins
Model' kompaktizatsii khromatina pri mozaichnom éffekte polozheniia gena.