Autonomic disturbance in severe tetanus: failure of parenteral clonidine to control blood pressure.
In this paper we describe a typical case of tetanus and report our observations with the centrally acting alpha 2-adrenoreceptor agonist clonidine. Previous work with this agent has suggested that it may be of value in tetanus.
Unit of Infectious Diseases and Tropical Medicine, St Mary's Hospital Medical School, Northwick Park Hospital, Middlesex, U.K.
J L
JL
Brown
H
H
Sinding
C J
CJ
Mathias
D000368:Aged; D000369:Aged, 80 and over; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007275:Injections, Intravenous; D008297:Male; D010243:Paralysis / Q000209:etiology; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D013742:Tetanus / Q000150:complications* / Q000188:drug therapy
D003000:Clonidine; D010400:Penicillin G