Sex hormones and lipoprotein metabolism.
Previous findings of increased production of large VLDL particles by estrogen have been confirmed in a trial using estrogen-dominant oral contraceptives. Estrogen has been found to have LDL subclass-specific effects and to shift the distribution of apolipoprotein (apo)E from HDL to VLDL. Several recent studies document decreases in lipoprotein (a) [Lp(a)] levels, but the metabolic mechanism is yet unknown. The effects of progestational agents on lipoprotein metabolism remain unclear in view of conflicting reports.
Sacks
F M
FM
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Walsh
B W
BW
D000728:Androgens / Q000494:pharmacology; D000818:Animals; D001055:Apolipoproteins B / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D051379:Mice; D011372:Progestins / Q000494:pharmacology
D000728:Androgens; D001055:Apolipoproteins B; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D008074:Lipoproteins; D011372:Progestins