Changes in the concentrations of tau and other structural proteins in the brains of aged mice.
To test whether aging is associated with alterations in the balance of cytoskeletal constituents, the relative concentrations of tau isoforms and seven other structural proteins were compared in the brains of 3-25-month-old mice. A tau species of approx. 63 kDa was substantially increased in the older animals while the levels of ankyrin, talin, spectrin, and actin were differentially decreased. The decrement in ankyrin was evident at earlier ages than that for spectrin. These results suggest that the make-up of the neuronal cytoskeleton changes with age.
Center for the Neurobiology of Learning and Memory/Bonney Center, University of California, Irvine 92717-3800.
B A
BA
Bahr
N
N
Lam
G
G
Lynch
D000199:Actins / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D017487:Ankyrins / Q000378:metabolism; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D013049:Spectrin / Q000378:metabolism; D016608:Talin / Q000378:metabolism; D013687:Telencephalon / Q000254:growth & development / Q000378:metabolism*; D016875:tau Proteins / Q000378:metabolism*
D000199:Actins; D017487:Ankyrins; D003598:Cytoskeletal Proteins; D016608:Talin; D016875:tau Proteins; D013049:Spectrin