Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their beta-lactamases. Canadian Haemophilus Study Group.
Susceptibility testing of 1,688 Haemophilus influenzae isolates found 484 ampicillin-resistant strains; 474 strains (28.4%) were beta-lactamase positive, and 5 strains (0.4%) were non-beta-lactamase producers. Restriction enzyme digestion of the beta-lactamase amplicon determined that, of 157 strains, 11 (7.0%) contained ROB-1 beta-lactamase and 146 (93.0%) contained a TEM-type beta-lactamase.
Scriver
S R
SR
Department of Microbiology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
Walmsley
S L
SL
Kau
C L
CL
Hoban
D J
DJ
Brunton
J
J
McGeer
A
A
Moore
T C
TC
Witwicki
E
E
D000668:Ampicillin Resistance / Q000235:genetics; D001483:Base Sequence; D002170:Canada; D004269:DNA, Bacterial; D006192:Haemophilus Infections / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012093:Replicon / Q000187:drug effects; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D004269:DNA, Bacterial; D065093:beta-Lactamase Inhibitors; C071165:beta-lactamse ROB-1; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1