Discordant uptake of Tc-99m DTPA-galactosyl human serum albumin and Tc-99m Sn colloid in a patient with severe acute hepatitis.
A patient with recently diagnosed severe acute hepatitis underwent serial liver scintigraphy with Tc-99m Sn colloid and Tc-99m DTPA-galactosyl human serum albumin. In initial studies, radionuclide distribution on Tc-99m DTPA-galactosyl human serum albumin scintigraphy was completely discrepant to that on Tc-99m Sn colloid scintigraphy. In a follow-up study 1 month later, the distribution of both radionuclides in the liver appeared relatively homogeneous. The uptake of Tc-99m DTPA-galactosyl human serum albumin and Tc-99m Sn colloid reflects the function of hepatocytes and Kupffer cells, respectively. Both kinds of scintigraphic study may be helpful to assess histopathologic change of different hepatic tissue architectures.
Miyazaki
C
C
Department of Diagnostic Radiology, Sapporo City General Hospital, Hokkaido, Japan.
Matsunaga
T
T
Kubo
K
K
D000208:Acute Disease; D000328:Adult; D003102:Colloids; D005260:Female; D005500:Follow-Up Studies; D006505:Hepatitis / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors; D017971:Tin Compounds; D015899:Tomography, Emission-Computed, Single-Photon
D003102:Colloids; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D017971:Tin Compounds; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; C033493:technetium Tc 99m tin colloid; D016284:Technetium Tc 99m Pentetate