Effects of cysteamine, a somatostatin depleter, on the renin-angiotensin-aldosterone axis and glomerulosa cell growth in rats.
Cysteamine, a specific somatostatin depleter, was given to male rats to clarify its role in relation to the renin-angiotensin-aldosterone (RAA) axis and glomerulosa cell growth. Rats received seven daily sc injections of cysteamine at doses of 50 or 150 mg/kg body weight (BW). Their adrenal weights and whole cortical thickness increased, but zona glomerulosa thickness decreased dose-responsively. Plasma renin activity (PRA) and aldosterone concentration (PAC) decreased. Similar results were observed in rats on a low or high salt diet and receiving daily doses of 150 mg/kg BW of cysteamine. In hypophysectomized rats, however, cysteamine given for seven days at daily doses of 100 mg/kg BW did not change either PRA or PAC. Adrenal weight did not change either too. Our results indicate that cysteamine suppresses the RAA axis and glomerulosa cell growth, probably through pituitary factors.
Department of Medicine, Tokyo Women's Medical College, Japan.
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Kikuchi
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Nomura
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Toraya
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Demura
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Aiba
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003543:Cysteamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007016:Hypophysectomy; D008297:Male; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage; D013004:Somatostatin / Q000378:metabolism*; D015384:Zona Glomerulosa / Q000166:cytology / Q000187:drug effects*
D017673:Sodium Chloride, Dietary; D013004:Somatostatin; D003543:Cysteamine