[Oncogenes and suppressor genes in the genesis and progression of solid tumors in children].
Molecular and genetic analyses of tumor cell show that cellular oncogenes and suppressor genes are involved in neoplastic transformation. In pediatric tumors oncogenes as N-myc play an important role in the tumor progression. In retinoblastoma, neuroblastoma, Wilms' tumor, and rhabdomyosarcoma loss of heterozygosity for specific chromosome loci has been suggested to be a critical step in cancer development. Oncogene abnormalities can also be useful as a molecular tumor factor to foresee the prognosis of the disease. The present article is a review on the role of the oncogenes and suppressor genes in pediatric solid tumors.
Laboratorio Scientifico di Oncologia, Istituto Scientifico G. Gaslini, Genova, Italia.
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Tonini
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Mazzocco
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Scaruffi
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D018450:Disease Progression; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*
Oncogeni e geni soppressori nella genesi e nella progressione dei tumori solidi del bambino.