Biphasic time-course of serum concentrations of clomipramine and desmethylclomipramine after a near-fatal overdose.
A 27-y-old male was admitted deeply comatosed 5-6 h after taking approximately 15 g clomipramine. The prominent feature of the case was a biphasic course of clomipramine and desmethylclomipramine serum concentrations, possibly caused by delayed drug absorption. Clinically, 2 serious episodes requiring mechanical ventilation and aggressive pressor agent infusions occurred as the serum concentrations declined. However, the severe adult respiratory distress syndrome--related inflammatory process that required 4 w of intensive care may also be an explanation, although blood cultures were negative and neither liver nor renal functions were severely compromised.
Dale
O
O
Department of Pharmacology and Toxicology, University of Trondheim Medical Center-Regionsykehuset i Trondheim, Norway.
Hole
A
A
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood* / Q000506:poisoning*; D062787:Drug Overdose; D006207:Half-Life; D006801:Humans; D008297:Male
C012273:desmethylclomipramine; D002997:Clomipramine