Activity of certain fractions of Tribulus terrestris fruits against experimentally induced urolithiasis in rats.
An ethanolic extract of the fruits of T. terrestris showed significant dose dependent protection against uroliths induced by glass bead implantation in albino rats. On subsequent fractionation of the ethanol extract, maximum activity was localised in the 10% aqueous methanol fraction. It provided significant protection against deposition of calculogenic material around the glass bead. It also protected leucocytosis and elevation in serum urea levels. Further, fractionation lead to decreased activity. This could be either due to loss of active compounds during fractionation, or the antiurolithiatic activity of T. terrestris being a combined effect of several constituents present in the methanolic fraction.
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
R
R
Anand
G K
GK
Patnaik
D K
DK
Kulshreshtha
B N
BN
Dhawan
D000818:Animals; D005591:Chemical Fractionation; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014545:Urinary Calculi / Q000188:drug therapy* / Q000209:etiology
D010936:Plant Extracts