Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23.
The autosomal recessive disorder ataxia-telangiectasia (A-T) is genetically heterogeneous, with four complementation groups. The genes for the two major groups (ATA and ATC) have been mapped to 11q22-q23. Genetic analysis of the disease has been conducted to date using biallelic polymorphisms. We have physically mapped to this region eight new microsatellite markers that were generated by three laboratories that construct whole-genome linkage maps. These markers should be valuable for refined localization and positional cloning of the A-T genes and for diagnostic purposes. The results demonstrate the value of integrating genetic and physical maps generated by different laboratories.
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
L
L
Vanagaite
K
K
Savitsky
G
G
Rotman
Y
Y
Ziv
S C
SC
Gerken
R
R
White
J
J
Weissenbach
G
G
Gillett
F J
FJ
Benham
C W
CW
Richard
M R
MR
James
F S
FS
Collins
Y
Y
Shiloh
D001260:Ataxia Telangiectasia / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D017931:DNA Primers / Q000235:genetics; D004276:DNA, Satellite / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data
D017931:DNA Primers; D004276:DNA, Satellite; D005819:Genetic Markers