[The C heterochromatin of chromosomes 1, 9, 16 and Y in patients with Noonan's syndrome].
A significant reduction in the total amount of C heterochromatin of chromosomes 1, 9, 16, and Y was detected in six patients with Noonan's syndrome. The results obtained do not contradict the results of our previous investigations of the correlation between a small amount of C heterochromatin and growth retardation. The clinical resemblance of Noonan's and Turner's syndromes with respect to the functional role of facultative and constitutive heterochromatin in early embryogenesis is discussed.
Podugol'nikova
O A
OA
Solonichenko
V G
VG
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D005260:Female; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D007223:Infant; D008297:Male; D008677:Metaphase; D009634:Noonan Syndrome / Q000473:pathology*; D014998:Y Chromosome / Q000648:ultrastructure*
D006570:Heterochromatin
Issledovanie C-geterokhromatina khromosom 1, 9, 16 i Y u patsientov s sindromom Nunen.