[Effect of plasmapheresis and immunocorrective therapy on the status of the T-cell component of immunity in patients with autoimmune thyroiditis].
T-cellular immunity was studied in 104 patients with autoimmune thyroiditis to assess the function of the thyroid and treatment method. A reliable reduction of the activity of T-lymphocyte receptor system, lymphopoiesis activation, and their relationship with the thyroid status were revealed. Plasmapheresis as monotherapy was used in 22 patients. It brought about a short-term positive effect, this necessitating search for other methods of immuno-rehabilitation. In 82 patients it was supplemented with immunocorrective therapy (thymalin) and in 49 with hypothyrosis with substitution therapy (L-thyroxine, thyroidin). Combined therapy helped attain a stable clinical and immunological effect. Subpopulation composition of T-lymphocytes recovered, their functional activity normalized (follow-up period 1 year).
Kalinin
A P
AP
Rafibekov
D S
DS
Potemkina
E E
EE
Shabadin
V N
VN
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D013601:T-Lymphocytes / Q000276:immunology*; D013951:Thymus Hormones / Q000627:therapeutic use*; D013963:Thyroid Hormones / Q000627:therapeutic use; D013967:Thyroiditis, Autoimmune / Q000276:immunology / Q000628:therapy*; D013974:Thyroxine / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D006728:Hormones; D013951:Thymus Hormones; D013963:Thyroid Hormones; C032805:thymalin; C004227:thyroidin; D013974:Thyroxine
Vliianie plazmafereza i immunokorrigiruiushcheĭ terapii na sostoianie T-kletochnogo zvena immuniteta u bol'nykh autoimmunnym tireoditom.