On the role of ADP to increase the inhibitory effect of cyclosporin on mitochondrial membrane permeability transition.
This work reports an investigation which demonstrate that the addition of ADP is necessary to attain the protective effect of cyclosporin on the carboxyatractyloside-induced mitochondrial Ca2+ release. Evidence are presented which indicate that the effect of ADP is exerted by increasing the inhibitory action of cyclosporin on the enzyme cyclophilin.
Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F., México.
C
C
Zazueta
H
H
Reyes-Vivas
N
N
Corona
C
C
Bravo
E
E
Chávez
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000591:Amino Acid Isomerases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology*; D004357:Drug Synergism; D004706:Endodeoxyribonucleases; D007425:Intracellular Membranes / Q000187:drug effects*; D008928:Mitochondria / Q000187:drug effects*; D019696:Peptidylprolyl Isomerase; D010539:Permeability / Q000187:drug effects; D051381:Rats
D002352:Carrier Proteins; D000244:Adenosine Diphosphate; D016572:Cyclosporine; D004706:Endodeoxyribonucleases; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase; D002118:Calcium