[18FDG-PET in intracranial meningiomas versus grading, proliferation index, cellular density and cytogenetic analysis].
62 intracranial meningiomas in 60 patients were studied with 18FDG-PET prior to neurosurgery in order to evaluate the relationship between 18FDG uptake and biological aggressiveness of the tumors. Histopathological grading, cellular density, Ki-67 proliferation index and evidence of chromosomal aberrations were used to assess tumor aggressiveness. Significantly elevated 18FDG uptake was found in grade 2- and 3- compared to grade 1-meningiomas, in tumors of high cellularity compared with those of low cellularity, and in meningiomas with an elevated Ki-67 proliferation index (above 2%). The two meningiomas with the most pronounced chromosomal aberrations revealed the highest 18FDG uptake of all cytogenetically studied meningiomas. We conclude that 18FDG-PET is useful for estimating the biological aggressiveness of intracranial meningiomas.
Kliniken für Nuklearmedizin, RWTH Aachen, FRG.
U
U
Cremerius
E
E
Striepecke
W
W
Henn
J
J
Weis
M
M
Mull
B
B
Lippitz
J
J
Gilsbach
J M
JM
Schröder
K D
KD
Zang
A
A
Böcking
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D002455:Cell Division; D003582:Cytogenetics; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology*; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose
18FDG-PET bei intrakraniellen Meningeomen versus Grading, Proliferationsindex, Zelldichte und zytogenetische Analyse.