Muscarinic involvement in vascular and adrenal medullary responses to splanchnic nerve stimulation in conscious calves.
Stimulation of the peripheral end of the right splanchnic nerve (4 Hz for 10 min) in the presence of hexamethonium caused a small but significant rise in mean aortic blood pressure which was subsequently abolished by atropine. There were also small but significant increases in the outputs of catecholamines, [Met5]-enkephalins and corticotrophin releasing factor (CRF) from the right adrenal gland. The catecholamine response was roughly halved after atropine while the outputs of enkephalins and CRF were unaffected. It is concluded that splanchnic sympathetic postganglionic neurones supplying the vasculature are completely blocked by cholinergic blockade whereas adrenal medullary responses persist in an attenuated form.
Laboratory of Cellular and Developmental Physiology, University of Oxford, England, UK.
C T
CT
Jones
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AV
Edwards
D000313:Adrenal Medulla / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D000818:Animals; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D002417:Cattle; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004558:Electric Stimulation; D004744:Enkephalin, Methionine / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D013153:Splanchnic Nerves / Q000187:drug effects / Q000502:physiology*
D002395:Catecholamines; D011976:Receptors, Muscarinic; D009270:Naloxone; D018738:Hexamethonium; D004744:Enkephalin, Methionine; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine; D004837:Epinephrine