[Local blood circulation, uptake of 45Ca, 85Sr and 3H-proline and mineral levels in the tibia of female rats: comparison and changes after administration of estradiol].
After six weeks' administration of estradiol benzoate (Agofollin Depot, 1 mg s.c. once a week) we determined in the first part of 70 days old female rats the uptake of 85Sr-microspheres and local blood flow in the tibia, in the second part 24 hours' incorporation of 45Ca and 3H-proline and in the third part 2 hours' uptake of 85Sr, bone density and ash weight related to 1 ml of bone volume. We observed the following statistically significant changes: decrease in the uptake of 85Sr-microspheres and local blood flow, decrease in the incorporation of 45Ca, 3H-proline and 85Sr, increase in the density and ash weight of the tibia. The rise of bone mineral content simultaneously with reduced indicators of bone formation and particularly of the mineralization seems to be in the connection with the suppression of bone resorption under the influence of estrogen. Qualitatively identical reactions of circulatory and metabolic indicators to the administration of estradiol may be a reflection of mutual physiological interconnections.
Laborator pro Endokrinologii a Metabolismus, 1. Lékarské Fakulty Univerzity Karlovy, Praha, Czech Republic.
J
J
Kapitola
J
J
Andrle
J
J
Kubícková
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002132:Calcium Radioisotopes / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D011392:Proline / Q000378:metabolism*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013326:Strontium Radioisotopes / Q000378:metabolism*; D013977:Tibia / Q000098:blood supply* / Q000737:chemistry / Q000378:metabolism*
D002132:Calcium Radioisotopes; D013326:Strontium Radioisotopes; D004958:Estradiol; D011392:Proline
Místní krevní obĕh, inkorporace 45Ca, 85Sr a 3H-prolinu a obsah minerálu v kosti holenni potkaních samic: srovnání zmĕn po podávání estradiolu.