[Study on mitoxantrone polycyanoacrylate nanospheres].
The mitoxantrone polybutylcyanoacrylate nanosparticles (DHAQ-PBCA-NP) were prepared by emulsion polymerization method. The surface charge, drug loading, morphology, size and size distribution, release characteristics in vitro, stability and distribution in animals of DHAQ-PBCA-NP were studied. The results showed that the mean size was d(av) = 55.23 nm, drug loading was 46.77%, embedding ratio was 84.89%. The surface carried negative charge and the release characteristics in vitro was in accord with two phases kinetics law. The colloidal solution of DHAQ-PBCA-NP can undergo boiling for 30 min sterilization. The radioactivity concentrated mainly in liver after iv 3H-DHAQ-PBCA-NP. The radioactivity in liver tumor was higher than that in the liver tissue. DHAQ-PBCA-NP was observed in parenchymal cell 15 min after iv DHAQ-PBCA-NS. This preparation seems to have important value for increasing the anti-liver tumor effect and decreasing the toxicity of DHAQ.
Zhang
Z R
ZR
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Liao
G T
GT
Hou
S X
SX
D000818:Animals; D003487:Cyanoacrylates; D004337:Drug Carriers; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008863:Microspheres; D008942:Mitoxantrone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009368:Neoplasm Transplantation
D003487:Cyanoacrylates; D004337:Drug Carriers; D008942:Mitoxantrone