In vitro reversal of chloroquine resistance with chlorpheniramine against African isolates of Plasmodium falciparum.
The in vitro chloroquine potentiating action of racemic chlorpheniramine was assessed by a semi-microtest against chloroquine-resistant African isolates of Plasmodium falciparum. At the chlorpheniramine concentrations of 312 and 625 nM, chloroquine resistance was reversed in 4 and 11 of 14 isolates, respectively, with a diminution of their 50% inhibitory concentration (IC50) values for chloroquine to below 100 nM. No effect was observed against the chloroquine-susceptible clone. The results of the study suggest that chlorpheniramine may be a promising chloroquine resistance modulator.
Centre National de Référence de la Chimiosensibilité du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, Paris, France.
L K
LK
Basco
J
J
Le Bras
D000349:Africa; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D002744:Chlorpheniramine / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects*
D002744:Chlorpheniramine; D002738:Chloroquine