A nine-year chronic toxicity study of cadmium in monkeys. II. Effects of dietary cadmium on circulatory function, plasma cholesterol and triglyceride.
The effects of long-term (9 y) po administration of daily low doses of cadmium on blood pressure, heart rate, electrocardiogram and plasma cholesterol and triglyceride concentrations were examined in rhesus monkeys. Thirty-five male rhesus monkeys were divided into 5 groups and fed pelleted food containing cadmium chloride at dosages of 0, 3, 10, 30 or 100 micrograms cadmium/g food (= ppm). The 100 ppm group had increased blood pressure during the initial 1 1/2 y. Thereafter, the expected increase in blood pressure that occurred due to aging in the control and 3 ppm groups was not evident in the 100 ppm group. No changes attributable to cadmium were detected in pulse rates or in electrocardiograms. Plasma cholesterol in the 2 highest dosage groups and triglyceride in the 100 ppm group were slightly lower than in controls after 2 1/2 y. Long-term exposure to cadmium contributed to the development of elevated blood pressure during the first and second years and then inhibited the hypertension expected due to aging.
Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
F
F
Akahori
T
T
Masaoka
S
S
Arai
K
K
Nomiyama
H
H
Nomiyama
K
K
Kobayashi
Y
Y
Nomura
T
T
Suzuki
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002104:Cadmium / Q000633:toxicity*; D002784:Cholesterol / Q000097:blood*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D008253:Macaca mulatta; D008297:Male; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D002104:Cadmium; D002784:Cholesterol