Catalase, superoxide dismutase and glutathione peroxidase activity in neutrophils of sham-operated and olfactory-bulbectomised rats following chronic treatment with desipramine and lithium chloride.
In the olfactory-bulbectomised rat model of depression, neutrophil phagocytosis was significantly decreased and phagocytosis started later in comparison to sham-operated animals. Both desipramine and lithium chloride treatment significantly reversed the depressed neutrophil phagocytosis and shortened the time to commencement of phagocytosis in drug-treated bulbectomised rats. The catalase and glutathione peroxidase (GSH-PX) activities in bulbectomised rats were decreased, while superoxide dismutase (SOD) was significantly increased. Chronic desipramine and lithium chloride treatment slightly improved catalase activity in the bulbectomised rats. Desipramine significantly reversed the reduction in activity of GSH-PX, but failed to reverse the increased activity of SOD. In contrast, lithium chloride significantly reversed SOD activity to normal values, without affecting GSH-PX activity in the bulbectomised rats.
Department of Pharmacology, University College, Galway, Ireland.
C
C
Song
A A
AA
Killeen
B E
BE
Leonard
D000818:Animals; D003866:Depressive Disorder / Q000503:physiopathology; D003891:Desipramine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000097:blood*; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D009830:Olfactory Bulb / Q000187:drug effects / Q000503:physiopathology* / Q000601:surgery; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood*
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D018021:Lithium Chloride; D003891:Desipramine