Severe hyperphosphatemia following acute tumor lysis syndrome.
We report on a 14-year-old boy with acute lymphoblastic leukemia (lymphoma-leukemia) who had two episodes of acute tumor lysis syndrome during induction of remission with oral prednisolone alone and oral prednisolone, intravenous vincristine, and doxorubicin, respectively. Subsequently he had severe hyperphosphatemia (29.3 and 14.1 mg/dl; 9.46 and 4.55 mmol/L), hypocalcemia, hyperuricemia, hyperkalemia, and azotemia. Multiple stones and tumor cells infiltration were demonstrated in both kidney. He responded favorably to hemodialysis.
Vachvanichsanong
P
P
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand.
Maipang
M
M
Dissaneewate
P
P
Wongchanchailert
M
M
Laosombat
V
V
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002675:Child, Preschool; D006801:Humans; D007669:Kidney Calculi / Q000209:etiology / Q000628:therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D010758:Phosphorus / Q000097:blood*; D006435:Renal Dialysis; D015275:Tumor Lysis Syndrome / Q000150:complications* / Q000209:etiology
D010758:Phosphorus