Pain during injection of propofol. The effect of prior administration of thiopentone.
A controlled, double-blind study was performed to compare the prior administration of intravenous saline 4 ml (n = 36), lignocaine 20 mg (n = 36) or thiopentone 100 mg (n = 43) on the pain produced by intravenous injection of propofol. One hundred and fifteen ASA 1 or 2 patients scheduled for minor surgery were studied using a randomised, double-blind design. Thiopentone was more effective than lignocaine in reducing the incidence of propofol injection pain (p < 0.03).
Department of Anaesthesia and Intensive Care, Townsville General Hospital, Queensland, Australia.
T W
TW
Lee
A E
AE
Loewenthal
J A
JA
Strachan
B D
BD
Todd
D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced* / Q000517:prevention & control; D011292:Premedication; D015742:Propofol / Q000009:adverse effects*; D013874:Thiopental / Q000627:therapeutic use*
D008012:Lidocaine; D013874:Thiopental; D015742:Propofol