[The development of a technology for lincomycin biosynthesis with batch-type feeding of the substrates during the process].
It was shown possible to improve the process of lincomycin production by using batch-type feeding of the carbohydrate substrates during the biosynthesis. The optimal composition of the fermentation medium with lower concentrations of the carbohydrates was developed and batch-type feeding of the substrates was applied. The conditions of the substrate feeding were developed under laboratory conditions. Solutions of glucose or sugar supplemented with potassium sulfate were used for the feeding. The antibiotic yield under the optimal conditions of the substrate feeding and the process control was higher than that under the conditions of the batch fermentation by 23-24 per cent.
L E
LE
Semenova
T S
TS
Sherstobitova
I B
IB
Gorokhova
D001431:Bacteriological Techniques; D003470:Culture Media; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D008034:Lincomycin / Q000096:biosynthesis*; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors
D003470:Culture Media; D008034:Lincomycin
Razrabotka tekhnologii biosinteza linkomitsina s drobnym dozirovaniem substratov po khodu protsessa.