Effects of cyproheptadine on TXB2 and 6-keto-PGF1 alpha plasma levels in rabbits with hemorrhagic shock.
Profound hemorrhagic shock was produced in 26 rabbits by exsanguination via carotid artery until blood pressure (BP) = 5.3 kPa (40 mmHg) for a period of 90 min. Rabbits were equally divided into a cyproheptadine (Cyp) treated group and a control group. The blood samples before and 90 min after shock and 30 min after liquid and blood infusion and administering Cyp (10 mg.kg-1) were collected from the carotid artery. With radioimmunoassay, we measured the thromboxane B2(TXB2) and 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) contents in plasma. The results indicated that the TXB2 and 6-keto-PGF1 alpha levels during shock (1024 +/- 924, 30 +/- 32) and after liquid and blood infusion (990 +/- 943, 60 +/- 54) were higher than those (221 +/- 134, 6 +/- 4) in normal rabbits (P < 0.01, P < 0.05). Cyp reduced obviously the TXA2 plasma level in rabbit with shock (304 +/- 299 vs 990 +/- 943, P < 0.05). We conclude that the decrease of TXB2 content is one of the possible mechanisms of cyproheptadine anti-shock effect.
Department of Pharmacology, Ji-ning Medical College, China.
Q Z
QZ
Zhang
Q
Q
Wang
C F
CF
Zhang
X Z
XZ
Ling
W Y
WY
Liu
L Y
LY
Jin
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000188:drug therapy; D013929:Thromboxane B2 / Q000097:blood*
D003533:Cyproheptadine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha