[A case of paraneoplastic limbic encephalitis in autoptic occult primary malignancy].
We report a case of limbic encephalitis in a 71-year-old male who presented with amnesia, confusion and disorientation. The patient's history of long standing alcoholism suggested the diagnosis of Korsakow syndrome. Autopsy, however, revealed a regional lymph-node metastasis of a small-cell bronchial carcinoma. No primary malignoma could be detected. These findings indicate that in cases of limbic encephalitis without detectable primary malignoma a paraneoplastic syndrome cannot be excluded. This has to be taken into consideration when discussing the etiology of limbic encephalitis (paraneoplastic versus virus-induced).
Pathologisches Institut, Universität Freiburg.
A
A
Pagenstecher
M
M
Franz
B
B
Volk
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D001921:Brain / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000473:pathology*; D006801:Humans; D008032:Limbic System / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*
Ein Fall von paraneoplastischer limbischer Enzephalitis bei autoptisch nicht nachweisbarem Primärmalignom.