[A cytomorphological basis for the correction of radiation-induced immunodeficiencies and hematopoietic depression using thymus and bone marrow peptides].
The correction of radiation-induced immunodeficiency and hematopoiesis depression in clinical setting (100 patients) and in experiments (160 animals) by peptide preparations of the thymus and bone marrow (thymalin, hemalin, thymogemine and synthetic thymalin analog thymogen) has been studied. Administration of the bone marrow and thymus recovery of damage to the thymus, bone marrow, spleen and lymph nodes, improved the function of circulating neutrophilic granulocytes. Thymalin was able to compensate for immune disturbances and reduce manifestations of asthenia.
Khmel'nitskiĭ
O K
OK
Grintsevich
I I
II
Kotov
V A
VA
Seryĭ
S V
SV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000818:Animals; D004338:Drug Combinations; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D011210:Power Plants; D011832:Radiation Injuries / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D018788:Radioactive Hazard Release; D013951:Thymus Hormones / Q000627:therapeutic use*; D014455:Ukraine
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D013951:Thymus Hormones; C070018:thymohemin; C032805:thymalin; C046163:hemalin
Tsitomorfologicheskoe obosnovanie korrektsii radiatsionnykh immunodefitsitov i depressii krovetvoreniia peptidami timusa i kostnogo mozga.