Peripheral iron metabolism in patients with Parkinson's disease.
To elucidate the possible role of peripheral metabolism of iron in the risk for developing Parkinson's disease (PD), we compared serum levels of iron, transferrin and ferritin, and 24-h iron excretion in urine after a single intramuscular dose of 1 mg/kg desferrioxamine, in 68 PD patients and their spouses as the control group. All these values did not differ significantly between the groups, they were not influenced by antiparkinsonian therapy, and they did not correlate with age, age at onset and duration of the disease, scores of the Unified PD Rating Scale or the Hoehn and Yahr staging in the PD group, with the exception of the 24-h urinary iron excretion with the duration of the disease (r = 0.32, p < 0.05). These results suggest that peripheral metabolism of iron is apparently unrelated to the risk of developing PD.
Cabrera-Valdivia
F
F
Department of Neurology, Hospital Universitario Príncipe de Asturias Alcalá de Henares, Madrid, Spain.
Jiménez-Jiménez
F J
FJ
Molina
J A
JA
Férnandez-Calle
P
P
Vázquez
A
A
Cañizares-Liébana
F
F
Larumbe-Lobalde
S
S
Ayuso-Peralta
L
L
Rabasa
M
M
Codoceo
R
R
D000368:Aged; D002940:Circadian Rhythm; D003676:Deferoxamine / Q000494:pharmacology; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007273:Injections, Intramuscular; D007501:Iron / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D014168:Transferrin / Q000378:metabolism
D014168:Transferrin; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine