The effect of oestradiol-17 beta on connective tissue protein in rat prostate.
The concentrations of collagen, non-collagenous protein and elastin in ventral and dorsolateral prostates in oestradiol-17 beta-treated rats were higher than in vehicle-treated rats. The in vivo incorporation rates of 3H-proline into these connective tissue proteins in ventral and dorsolateral prostates were reduced following oestradiol-17 beta-treatment. The degradation rate of 3H-proline incorporated into each connective tissue protein was lowest in oestradiol-17 beta-treated animals. These findings indicate that the accumulation of collagen, non-collagenous protein and elastin in prostates of oestradiol-17 beta-treated rats can be largely accounted for by the suppressed degradation of biosynthesis of these connective tissue proteins.
Department of Urology, Yamagata University School of Medicine, Japan.
T
T
Nakada
Y
Y
Kubota
I
I
Sasagawa
H
H
Suzuki
M
M
Watanabe
Y
Y
Suzuki
D000818:Animals; D002369:Castration; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects*; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D004549:Elastin / Q000096:biosynthesis / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D011392:Proline; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000494:pharmacology; D013936:Thymidine
D011506:Proteins; D013739:Testosterone; D004958:Estradiol; D003094:Collagen; D004549:Elastin; D011392:Proline; D013936:Thymidine