Premarin-induced ischemic colitis.
There are numerous literature reports of oral contraceptive-induced (estrogen and progesterone) ischemic bowel disease. However, Premarin-induced (equine conjugated estrogen) intestinal ischemia has rarely been reported. We describe three cases of Premarin-induced ischemic colitis. In contrast to oral contraceptive-induced ischemic colitis, Premarin-induced ischemia is restricted to the colon, has not required surgical therapy, can have a chronic or chronic intermittent course, may be reversible despite continued usage of Premarin, and may present with nonspecific abdominal and colonic symptoms.
Gurbuz
A K
AK
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Gurbuz
B
B
Salas
L
L
Rosenshein
N B
NB
Donowitz
M
M
Giardiello
F M
FM
D000328:Adult; D017091:Colitis, Ischemic / Q000139:chemically induced*; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D004966:Estrogens, Conjugated (USP)