Macrolide antibiotics protect against endotoxin-induced vascular leakage and neutrophil accumulation in rat trachea.
We studied the effects of macrolides on lipopolysaccharide (LPS)-induced airway inflammation in the rat tracheal mucosa. Erythromycin and roxithromycin dose dependently inhibited microvascular leakage and neutrophil recruitment induced by LPS. This inhibitory action on vascular permeability was abolished by neutrophil depletion.
First Department of Medicine, Tokyo Women's Medical College, Japan.
J
J
Tamaoki
N
N
Sakai
E
E
Tagaya
K
K
Konno
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D004917:Erythromycin / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism*; D008070:Lipopolysaccharides; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D015575:Roxithromycin / Q000494:pharmacology; D014132:Trachea / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology
D000900:Anti-Bacterial Agents; D004731:Endotoxins; D008070:Lipopolysaccharides; D015575:Roxithromycin; D004917:Erythromycin; C044101:endotoxin, Escherichia coli