Neonatal thrombocytopenia in HLA-DR, -DQ, -DP-typed mother due to rare anti-HPA-1b (PLA2) (Zwb) fetomaternal immunization.
A new case of rare neonatal alloimmune thrombocytopenia, due to an IgG anti-HPA-1b in a mother HPA-1 (a+, b-), was diagnosed using monoclonal antibody-specific immobilization of platelet antigens. Clinically, it was similar to the 2 previously reported observations and confirmed that, in this particular case of anti-HPA-1b, the treatment with random platelet pools may be as effective as selected single-donor platelet units when maternal platelets are unusable. The HLA-DR, -DQ, -DP genotypes of the family were obtained by PCR-SSO. The mother's typing, compared to the HLA-DR of the 6 similar cases reported in Europe, suggests that a combined effect of two rare HLA haplotypes might enhance this immunization.
Mercier
P
P
Centre Régional de Transfusion Sanguine de Marseille, France.
Chicheportiche
C
C
Reviron
D
D
Dabanian
C
C
Bourgue
F
F
Chiaroni
J
J
Diallo
M
M
Delord
Y
Y
D000328:Adult; D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology*; D001803:Blood Transfusion; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange; D010976:Platelet Count; D017713:Platelet Transfusion; D011247:Pregnancy; D011693:Purpura / Q000151:congenital / Q000209:etiology; D013921:Thrombocytopenia / Q000151:congenital* / Q000175:diagnosis / Q000209:etiology
D016824:Antigens, Human Platelet; D006681:HLA-D Antigens; D007074:Immunoglobulin G; D007518:Isoantibodies; C083451:human platelet antigen 1b