Hypocrellin, from Hypocrella bambuase, is phototoxic to human immunodeficiency virus.
Hypocrellin, a photodynamic perylene quinonoid isolated from the Chinese medicinal fungus Hypocrella bambuase, was evaluated for antiviral activity against the human immunodeficiency virus (HIV-1). Hypocrellin was phototoxic to HIV-1, almost as good as the structurally similar plant pigment hypericin, and like hypericin its activity required visible light. In contrast peroxyhypocrellin had little or no effect on the virus.
Department of Pathology, University of British Columbia, Vancouver, Canada.
J B
JB
Hudson
J
J
Zhou
J
J
Chen
L
L
Harris
L
L
Yip
G H
GH
Towers
D016475:3T3 Cells; D000818:Animals; D000873:Anthracenes; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects* / Q000528:radiation effects; D003624:Darkness; D015497:HIV-1 / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D006999:Hypocreales / Q000737:chemistry; D008027:Light; D051379:Mice; D010569:Perylene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D019800:Phenol; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology
D000873:Anthracenes; D000998:Antiviral Agents; D011809:Quinones; D011838:Radiation-Sensitizing Agents; D019800:Phenol; D010569:Perylene; C004965:hypericin; C090289:peroxyhypocrellin; C048388:hypocrellin A