Retinal toxicity of high dose intravitreal ganciclovir.
BACKGROUND
Intravitreal administration of ganciclovir has been used to treat cytomegalovirus (CMV) retinitis in patients with acquired immune deficiency syndrome (AIDS) who are unable to tolerate systemic antiviral therapy. Although retinal toxicity from intravitreal ganciclovir has been observed in animal experiments, to our knowledge, retinal toxicity from intravitreal ganciclovir has not been reported in humans.


METHODS
A case of inadvertent intravitreous injection of a high dose of ganciclovir (40 mg/0.1 ml) for CMV retinitis in a patient with AIDS is presented.


RESULTS
Despite immediate intervention with vitreous surgery, permanent retinal damage and visual loss developed. Clinical observations and photographic documentation are provided.


CONCLUSIONS
Retinal toxicity can occur from a high-dose intravitreal ganciclovir injection. This toxicity may result from the high alkaline nature of this preparation, from osmotic damage, or from a direct effect of the concentrated ganciclovir.
Saran
B R
BR
Retina Service, Scheie Eye Institute, Philadelphia, Pennsylvania 19104.
Maguire
A M
AM
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D001766:Blindness / Q000139:chemically induced; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy; D005654:Fundus Oculi; D015774:Ganciclovir / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008508:Medication Errors; D012160:Retina / Q000187:drug effects*; D012164:Retinal Diseases / Q000139:chemically induced*; D014792:Visual Acuity; D014822:Vitreous Body
D015774:Ganciclovir