The effect of ciclotropium on human heart rate.
Ciclotropium is a recently developed parasympathicolytic agent. Plasma concentration and heart rate increase (the most prominent anticholinergic effects) were measured in 12 healthy subjects before, during and after a 15-min intravenous infusion of 10 mg ciclotropium. The effect was described by using either a linear or a nonlinear (Emax) effect model linked to a linear three-compartment kinetic model via an effect compartment. Maximum heart rate increase was 33 (10) beats.min-1, and half-value duration of effect was 41 (9) min. Total plasma clearance was 0.51 (0.13) l.min-1, and mean terminal elimination half-life was 12(4) h, whereas the equilibration half-lives of drug removal from the effect compartment ranged from 2 to 14 min.
Department of Clinical Pharmacology, University Medical Centre, Heidelberg, Germany.
R W
RW
Ding
R E
RE
Port
K
K
Ortmann
B
B
Liebmann
H
H
Spahn-Langguth
E
E
Mutschler
E
E
Weber
D000328:Adult; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018592:Cross-Over Studies; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D010276:Parasympatholytics / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D014326:Tropanes
D019086:Bridged Bicyclo Compounds, Heterocyclic; D010276:Parasympatholytics; D014326:Tropanes; C040095:cyclotropium