Induction of oxygen free radical generation in human monocytes by lipoprotein(a).
The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)] levels with atherosclerotic disease is unknown. In the present study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may provide a link between Lp(a) and generation of oxidized LDL, which can promote multiple atherogenic cellular responses.
Department of Medicine B, Rigshospitalet, University of Copenhagen, Denmark.
P
P
Riis Hansen
A
A
Kharazmi
M
M
Jauhiainen
C
C
Ehnholm
D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000494:pharmacology*; D008163:Luminescent Measurements; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016897:Respiratory Burst
D017270:Lipoprotein(a); D017382:Reactive Oxygen Species