Molecular chaperones in cellular protein folding.
The discovery of 'molecular chaperones' has dramatically changed our concept of cellular protein folding. Rather than folding spontaneously, most newly synthesized polypeptide chains seem to acquire their native conformation in a reaction mediated by these versatile helper proteins. Understanding the structure and function of molecular chaperones is likely to yield useful applications for medicine and biotechnology in the future.
Martin
J
J
Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Hartl
F U
FU
D001419:Bacteria / Q000378:metabolism; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D017510:Protein Folding
D018832:Molecular Chaperones