[A case of minocycline-induced pneumonitis with bronchial asthma].
We report a case of minocycline-induced pneumonitis. A 30-year-old woman was treated with minocycline for mycoplasma pneumonia of the right upper lobe. About 15 days after starting treatment, she developed a productive cough, stridor, and dyspnea. The chest X-ray film showed pulmonary infiltration in the left middle lung field. Based on the clinical history and the detection of eosinophilia in the bronchoalveolar fluid, drug-induced pneumonitis was suspected. Treatment with minocycline was discontinued and prednisolone (20 mg/day) was started, after which her symptoms subsided and there was marked regression of the pulmonary infiltrates on chest X-ray films. The lymphocyte stimulation test for minocycline was negative, but the diagnosis was confirmed by a positive oral provocation test.
Department of Internal Medicine, Himeji National Hospital, Hyogo, Japan.
T
T
Haruna
Y
Y
Mochizuki
Y
Y
Nakahara
R
R
Kawanami
T
T
Kawamura
H
H
Hashimoto
K
K
Tsuyuguchi
Y
Y
Matsushita
D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008911:Minocycline / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced*
D008911:Minocycline