Pitfalls in aminoacid and organic acid analysis: 3-hydroxypropionic aciduria.
Pitfalls in organic acid analysis can originate from inadequate methodology, analytical interferences, in vivo interactions and from pre-analytical conditions which often are unknown to the specialized analytical laboratory. Among the latter, ingested food and additives, metabolites of food processing or medications have to be considered. Bacterial metabolites from the gastrointestinal or urogenital system or formed after sample collection can lead to pitfalls as well. An example of such a patient whose urinary metabolites mimic at first glance inherited propionic aciduria is described.
Bachmann
C
C
Laboratoire Central de Chimie Clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Boulat
O
O
Meyrat
B J
BJ
Colombo
J P
JP
Pilloud
P
P
D000592:Amino Acid Metabolism, Inborn Errors / Q000175:diagnosis* / Q000652:urine; D003937:Diagnosis, Differential; D006801:Humans; D007231:Infant, Newborn; D007773:Lactates / Q000652:urine*; D019344:Lactic Acid / Q000031:analogs & derivatives*; D008297:Male; D013048:Specimen Handling
D007773:Lactates; D019344:Lactic Acid; C031601:hydracrylic acid