[Cytogenetic and medical genetic research on families with a high predisposition for the development of cancer of the gastrointestinal tract].
Three families suspected of predisposition to tumor development in the gastrointestinal tract have been followed in a medico- and cytogenetical study. According to genealogical analysis, cancer predisposition was confirmed in one family only. However, both specific and non-specific signs of genome instability and possible malignant transformation of cells were identified in members of the other two families.
A S
AS
Monakhov
A V
AV
Guliaev
D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D004198:Disease Susceptibility; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000209:etiology / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors
Tsitogeneticheskoe i mediko-geneticheskoe issledovanie v sem'iakh s vysokoĭ predraspolozhennost'iu k razvitiiu raka zheludochno-kishechnogo trakta.