Sequence of the cDNA encoding murine CRK4 protein kinase.
A cDNA clone encoding murine CRK4 protein kinase [Ershler et al., Gene 124 (1993) 305-306] has been isolated and sequenced. The deduced amino acid (aa) sequence shows 85% overall identity with the Xenopus laevis MO15 PK (the catalytic subunit of CAK). The central parts of the CRK4 and MO15 proteins are characterized by an unusually high (97.5%) degree of aa sequence conservation.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow.
Stepanova LYu
M A
MA
Ershler
A V
AV
Belyavsky
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001853:Bone Marrow / Q000201:enzymology*; D003001:Cloning, Molecular; D003062:Codon; D017124:Conserved Sequence; D018844:Cyclin-Dependent Kinases; D018076:DNA, Complementary / Q000096:biosynthesis / Q000737:chemistry; D015723:Gene Library; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014982:Xenopus laevis; D000095043:Cyclin-Dependent Kinase-Activating Kinase
D003062:Codon; D018844:Cyclin-Dependent Kinases; D018076:DNA, Complementary; D017346:Protein Serine-Threonine Kinases; D000095043:Cyclin-Dependent Kinase-Activating Kinase; C090586:Cdk7 protein, mouse