Oral minocycline improved keratosis follicularis squamosa (Dohi) and related disorder: bacterial factors are possibly involved in abberant keratinization.
Three cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50-100 mg/day). The clinical effect first appeared at 2 weeks after the initiation of therapy and no recurrence was observed for more than 3 months without minocycline. Gram positive cocci were demonstrated inside the hair follicle and horny layers in all 4 case. Minocycline might modulate abberant keratinization through its bactericidal effects in these keratinizing disorders.
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
I
I
Katayama
H
H
Yokozeki
K
K
Nishioka
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000302:isolation & purification*; D002648:Child; D007644:Darier Disease / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage* / Q000627:therapeutic use; D012867:Skin / Q000382:microbiology / Q000473:pathology
D008911:Minocycline