[Anti-inflammatory effects of pilose antler peptide].
Pilose antler peptide (PAP:MW:7200; amino acid residue:68) isolated from the antlers of Cervus nippon temminck 10 and 20 mg.kg-1 i.p. produced inhibitions towards acute and chronic inflammations in a dose-dependent manner. PAP reduced ascorbic acid and cholesterol contents in adrenal glands and decreased the serum hydrocortisone level of rats. The reduction of ascorbic acid and cholesterol contents were unaffected by the pretreatment of dexamethasone. PAP also showed an anti-inflammatory action on the swelling of carrageenan-induced hind paw in adrenalectomized rats. The results suggest that the anti-inflammatory effects of PAP do not depend absolutely on pituitary-adrenal system.
Zhang
Z Q
ZQ
Academy of Traditional Medicine and Materia Medica of Jilin Province, Changchun, China.
Wang
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Zhang
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Zhang
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Zhang
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Wang
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D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000999:Antlers / Q000737:chemistry; D001205:Ascorbic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003670:Deer; D004487:Edema / Q000188:drug therapy; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008419:Materia Medica / Q000737:chemistry; D051379:Mice; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008419:Materia Medica; D010455:Peptides; D002784:Cholesterol; D001205:Ascorbic Acid; D006854:Hydrocortisone