Major histocompatibility (B) complex control of the formation of v-src-induced metastases.
Previous observations have shown that the major histocompatibility (B) complex is a determinant of the growth of v-src-induced primary tumors. In the present study, we have observed with two chicken lines congenic for B complex alleles that the control of v-src-mediated oncogenesis by the B complex extends to metastasis formation. In addition, our results show that the differences in metastasis frequencies between these two lines are correlated with the relative strengths of their respective tumor immune responses.
Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824.
R L
RL
Taylor
J M
JM
England
G C
GC
Kopen
A A
AA
Christou
M S
MS
Halpern
D000818:Animals; D017849:Animals, Inbred Strains / Q000235:genetics / Q000276:immunology; D001358:Avian Sarcoma Viruses / Q000235:genetics* / Q000276:immunology; D002645:Chickens / Q000235:genetics / Q000276:immunology*; D016391:Genes, src; D008285:Major Histocompatibility Complex / Q000502:physiology*; D001357:Sarcoma, Avian / Q000235:genetics / Q000276:immunology* / Q000556:secondary*