[Antiatherogenic action of heparin].
Heparin is a highly sulfated glycosaminoglycan with many functions such as antilipemic and antithrombotic. In spite of these activities heparin is able to inhibit vascular smooth muscle cells proliferation and migration what seems to be very important event in the pathogenesis of atherosclerosis. The molecular mechanism of the action of heparin on smooth muscle cells has not been completely understood. Heparin inhibits growth factors binding to their receptors, oncogenes expression and has influence on the extracellular matrix protein deposition in the artery wall.
Katedra i Zakład Biochemii i Chemii Slaskiej Akademii Medycznej, Katowicach.
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M
Stajszczyk
J
J
Gmiński
D000818:Animals; D001158:Arteries / Q000187:drug effects; D001161:Arteriosclerosis / Q000517:prevention & control*; D005109:Extracellular Matrix / Q000187:drug effects; D006133:Growth Substances / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects
D006133:Growth Substances; D006493:Heparin
Przeciwmiazdzycowe działanie heparyny.