Biosynthetic capacities of actinomycetes. 2. Juglomycin Z, a new naphthoquinone antibiotic from Streptomyces tendae.
A new juglomycin-type antibiotic was identified by a HPLC-diode array screening technique in the culture filtrate of Streptomyces tendae Tü 901/8c. Juglomycin Z (1) differs from all other known juglomycin compounds by an additional methyl group in position 3 of the naphthoquinone ring system. Juglomycin Z is antibiotically active against Gram-positive and Gram-negative bacteria and against yeasts.
Biologisches Institut, LB Mikrobiologie/Antibiotika, Universität Tübingen, Germany.
H P
HP
Fiedler
A
A
Kulik
T C
TC
Schüz
C
C
Volkmann
A
A
Zeeck
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C090478:juglomycin Z