Synthesis of imidazo[2,1-b]thiazoles and thiazolines as potential antiulcer agents.
The replacement of the imidazole ring of cimetidine with a bicyclic system (imidazo[1,2-a]pyridine), reported in the literature, produced compounds endowed with potent antiulcer activity. In this paper we describe the synthesis of imidazo [2,1-b]thiazoles and thiazolines bearing the side chain of metiamide, cimetidine and ranitidine: the compounds obtained, tested on gastric lesions induced in rats by ethanol and by stress, were devoid of antiulcer activity.
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
A
A
Andreani
M
M
Rambaldi
A
A
Leoni
A
A
Locatelli
G
G
Pifferi
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000517:prevention & control; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D007093:Imidazoles; D013844:Thiazoles