[The use of clindamycin in the prevention and treatment of infectious complications in the cancer clinic].
Clindamycin used alone or in combination with other antimicrobial drugs such as aminoglycosides, dioxidin and fluoroquinolones in the prophylaxis and treatment of infectious complications in oncological patients was shown to be highly efficient. When clindamycin was used prophylactically in combination with netilmicin, the postoperative infectious complications developed in 3 out of 27 patients with tumors of the head and neck, in 1 out of 24 patients with tumors of the rectum and colon and in 3 out of 16 patients with tumors of the female genitalia. The clinical effect was observed in 36 (87.8 per cent) out of 41 patients with postoperative wound infections and in 38 (82.5 per cent) out of 40 patients with pneumonia. Therefore, the use of clindamycin alone or in combination with other antimicrobial drugs is essential in the treatment of infectious complications in oncological patients.
Dmitrieva
N V
NV
D000293:Adolescent; D000328:Adult; D000368:Aged; D002981:Clindamycin / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D009428:Netilmicin / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D012074:Remission Induction; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*
D002981:Clindamycin; D009428:Netilmicin
Primenenie klindamitsina pri profilaktike i lechenii infektsionnykh oslozhneniĭ v onkologicheskoĭ klinike.