In vivo distribution of ferric-ATP complex.
At physiological pH, ferric-ATP complex presents ionic characteristics unlike those of ferric lactate. Its rapid diffusion into the tissues, and its reactivity which is not impaired by polymerization seem responsible for its toxicity. In comparison with ferric lactate, after parenteral administration there is a much higher spleen, lung, kidney and bone accumulation. After oral administration, on the other hand, the values are lower. ATP hydrolysis by the stomach's pH, and the subsequent iron insolubilization as phosphate could be the reason for this behaviour.
Anghileri
L J
LJ
Biophysics Laboratory, Medicine Faculty, University of Nancy, France.
Robert
J
J
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000818:Animals; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007504:Iron Radioisotopes; D051379:Mice; D014018:Tissue Distribution
D005290:Ferric Compounds; D007504:Iron Radioisotopes; D000255:Adenosine Triphosphate; C045858:ferric-adenosine triphosphate complex