Potentiation by capsaicin of lidocaine's tonic impulse block in isolated rat sciatic nerve.
Compound action potentials (CAPs) of A- and C-fibers were recorded from isolated sciatic nerves of the rat to determine whether tonic block of impulse conduction induced by lidocaine was affected by low doses of capsaicin. Capsaicin alone (50 microM) did not change the CAPs of either A- or C-fibers. Although the lower concentrations of capsaicin (5-30 microM) caused no change of the tonic blocking action of lidocaine, 30 min of 50 microM capsaicin administration did induce a significant potentiation of tonic block. Capsaicin's potentiating effects were partially reversed after 30 min of wash. These results suggest that capsaicin may be a useful agent for the potentiation of impulse blockade by lidocaine.
Shin
H C
HC
Department of Physiology, College of Medicine, Hallym University, Chunchon, South Korea.
Park
H J
HJ
Raymond
S A
SA
Strichartz
G R
GR
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004357:Drug Synergism; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects; D009413:Nerve Fibers, Myelinated / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects*
D008012:Lidocaine; D002211:Capsaicin