Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation.
We examined the therapeutic value of an interleukin-1 inhibitor on brain edema formation using a transient focal ischemia model in rats. Rats were given an interleukin-1 blocker, or interleukin-1 release inhibitor immediately after reperfusion. In rats treated with interleukin-1 inhibitor, ischemic brain edema 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. The simultaneous application of an IL-1 release inhibitor and a lipoxygenase inhibitor showed an additive beneficial effect on brain edema formation. These findings suggest that blocking IL-1 activity ameliorates brain edema and attenuates the neuronal damage induced by focal transient ischemia in rats.
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Y
Y
Yamasaki
H
H
Shozuhara
H
H
Onodera
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K
Kogure
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology*; D001929:Brain Edema / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology*; D002421:Caudate Nucleus / Q000187:drug effects / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology*; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000502:physiology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008297:Male; D011524:Protoporphyrins / Q000494:pharmacology*; D011699:Putamen / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012795:Sialoglycoproteins / Q000494:pharmacology*
D016227:Benzoquinones; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D016859:Lipoxygenase Inhibitors; D011524:Protoporphyrins; D012795:Sialoglycoproteins; C017803:zinc protoporphyrin; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone