[Analysis of the mutagenic and teratogenic effect of griseofulvin in the mutagen-sensitive Drosophila melanogaster line mus(2)201G1].
The mutagenic effect of griseofulvin was demonstrated in a wing somatic mosaicism test (SMART) in different Drosophila lines. The mutagenic effect of this agent is accompanied by a pronounced toxic effect on Drosophila larvae and by a teratogenic effect, which is manifested in the reduction of ommatidia, phenocopying the mutation ey (eyeless-4:2.0). A relationship was shown between the level of the phenocopies and the dose of griseofulvin (GF), the genotypes of the treated larvae, the interval and duration of GF exposure, and also sexual differences. The lowest level of phenocopies is recorded for the line developed on the basis of the mutagen-sensitive mutation mus(2)201G1, which blocks excision repair.
Isaenko
O A
OA
Romashkina
T B
TB
Shvartsman
P Ia
PIa
Shelomova
L F
LF
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005838:Genotype; D006118:Griseofulvin / Q000633:toxicity*; D008297:Male; D009030:Mosaicism; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D013723:Teratogens / Q000633:toxicity*
D009153:Mutagens; D013723:Teratogens; D006118:Griseofulvin
Analiz mutagennogo i teratogennogo éffekta grizeoful'vina u mutagenchuvstvitel'noĭ linii mus(2)201G1 Drosophila melanogaster.