Mesalazine induced interstitial nephritis.
5-Aminosalicylic acid (5-ASA) has structural similarities to both phenacetin and aspirin, which are known to cause 'analgesic nephropathy'. Because of the increasing use of 5-ASA, this paper draws attention to two cases of severe interstitial nephritis resulting from 5-ASA and emphasises the importance of monitoring renal functions of patients with inflammatory bowel diseases who are receiving 5-ASA preparations.
Thuluvath
P J
PJ
West Middlesex University Hospital, Isleworth.
Ninkovic
M
M
Calam
J
J
Anderson
M
M
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D019804:Mesalamine; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
D000636:Aminosalicylic Acids; D019804:Mesalamine