Palatability of a meal influences release of beta-endorphin, and of potential regulators of food intake in healthy human subjects.
The effect of the palatability of a meal was tested on the post-prandial release of several gut hormones or neuropeptides which are known to have an effect on intake and satiety. Hormonal response was determined in plasma during the 3 h after a highly palatable and energy-rich meal or after the same meal served cold in a poorly acceptable form, as well as while fasting. The early post-prandial pancreatic polypeptide and neurotensin response was significantly higher after the highly palatable meal than after the cold one. Later responses differed only for pancreatic polypeptide. No difference was observed in cholecystokinin and neuropeptide Y levels. Post-prandial levels of beta-endorphin were elevated only after the cold meal and were associated with an elevated response of ACTH. We suggest that beta-endorphin might be secreted in response to an aversion towards the non-palatable cold meal. This could, subsequently, inhibit the cephalic phase of pancreatic polypeptide response and the early post-prandial response of neurotensin by a central anticholinergic effect. This study evidences an effect of palatability on the modulation of the digestive hormonal response after a meal.
Melchior
J C
JC
Laboratoire de Nutrition Humaine, Unité INSERM 286, CHU Bichat, Paris, France.
Rigaud
D
D
Chayvialle
J A
JA
Colas-Linhart
N
N
Laforest
M D
MD
Petiet
A
A
Comoy
E
E
Apfelbaum
M
M
D000328:Adult; D001066:Appetite; D004435:Eating / Q000523:psychology*; D005215:Fasting; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000097:blood / Q000378:metabolism; D011863:Radioimmunoassay; D013649:Taste; D001615:beta-Endorphin / Q000097:blood / Q000378:metabolism*
D009479:Neuropeptides; D001615:beta-Endorphin