[The effect of x-ray contrast agents on the rheological properties of the blood].
The effects of X-ray contrast agents on human blood rheology were investigated. The main cause of rheological effects of X-ray contrast media is their action on the structure and function of erythrocytes. There was a relationship between the physicochemical properties and the mechanism of action. The major active factor is the high osmolality of X-ray contrast media solutions. Lipid solubility, specific features of molecular structures and the composition of a dosage form played a definite role.
Usenko
A N
AN
Shimanovskiĭ
N L
NL
Firsov
N N
NN
Smirnova
O Iu
OIu
D000293:Adolescent; D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D003287:Contrast Media
Vliianie rentgenokontrastnykh sredstv na reologicheskie svoĭstva krovi.