Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma.
A 66-year-old woman presented clinical findings of Eaton-Lambert (myasthenic) syndrome (ELS). Fifteen months later, large-cell pulmonary carcinoma was detected. After systemic chemotherapy and radiotherapy, the tumor regressed and neurologic function improved. Although ELS is usually associated with pulmonary small-cell carcinoma, a minority of tumors are of squamous or glandular differentiation. We believe this is the first case report of ELS associated with large-cell neuroendocrine carcinoma in the English language literature, and it illustrates the importance of an aggressive approach to diagnosis and treatment.
Division of Oncology (Fred Hutchinson Cancer Research Center), University of Washington, Seattle, WA.
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T
Demirer
J
J
Ravits
D
D
Aboulafia
D000368:Aged; D018287:Carcinoma, Large Cell / Q000150:complications* / Q000188:drug therapy; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000175:diagnosis; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy