[Mechanisms of increasing the proliferation of hematopoietic cells. Growth factors and inhibitors. Historical perspectives].
The healing of a wound or blood cell regeneration following a hemorrhage illustrates the existence of strong homeostatic mechanisms. The numbers of cells are maintained constant through a powerful control system of cell proliferation in the skin and bone marrow. For example, the control mechanisms were not understood at the beginning of the century and the first evidence of a humoral factor was reported in 1905 by P. Carnot and Deflandre. They found that after bleeding a rabbit, there was in its serum 24 hours later some factor which stimulated red cell production in normal rabbits. They called it hemopoietin, but it was later called erythropoietin. During the past decades, abscopal effects strongly supported the role of humoral factors. Further progress has been made. The first was the description of the growth factor cell receptor system by S. Cohen and R. Levy-Montalcini. This system which was initially described for skin is also valid for hemopoiesis and lymphopoiesis. Another major progress was the concept of hemopoietic stem cells. The first control mechanisms which regulate proliferation and differentiation in hematopoietic tissue were elucidated less than 25 years ago. Enormous progress has since been made to enable the purification and identification of several growth and inhibitory factors which already have their place in daily clinical practice. Their clinical role will continue to grow and a better understanding of these mechanisms will make a fundamental contribution to cellular biology.
Institut Gustave Roussy.
M
M
Tubiana
D000818:Animals; D002455:Cell Division / Q000502:physiology; D006131:Growth Inhibitors / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans
D006131:Growth Inhibitors; D006133:Growth Substances
Les mécanismes de croissance de la prolifération des cellules hématopoïétiques. Facteurs de croissance et inhibiteurs. Perspectives historiques.