Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fibre intake and low urine volume to be added to the list.
Risk factors for low urinary citrate excretion were assessed in 34 consecutive male recurrent idiopathic calcium stone formers (RCSF) who collected two 24-h urines while on free-choice diet. Overt hypocitraturia (hypo-cit) was defined as UCit x V < 1.70 mmol/day, and 'low' citraturia (low-cit) as UCit x V between 1.70 and 2.11 mmol/day. Twenty-three RCSF had normocitraturia (normo-cit), six low-cit and five hypo-cit. UCit x V positively correlated with urine volume (VOLUME, r = 0.44, P = 0.009), vegetable fibre intake (fibers, r = 0.46, P = 0.009) and GI-alkali absorption (alkali, r = 0.47, P = 0.006), and volume, fibres and alkali tended to be lower among RCSF with low-/hypo-cit. A 3-day NH4Cl loading test (0.95 mEq/kg BW daily in 3 doses) was performed in RCSF as well as in 14 age-matched healthy male controls (C). On a plot of urine pH versus serum bicarbonate, 10 of 11 RCSF with low-/hypo-cit, but only six of 23 with normo-cit (P = 0.0004) fell off the normal range, indicating incomplete RTA. Two or more risk factors simultaneously occurred in only four of 23 RCSF with normo-cit, but in eight of 11 with low-/hypo-cit (P = 0.002). In conclusion, incomplete RTA is the most prevalent risk factor for low-/hypo-cit in RCSF, and decreases in vegetable fibres and urine volume emerge as two new risk factors for low urinary CIT.
Policlinic of Medicine, University Hospital, Berne, Switzerland.
B
B
Hess
R
R
Michel
R
R
Takkinen
D
D
Ackermann
P
P
Jaeger
D000141:Acidosis, Renal Tubular / Q000150:complications; D000328:Adult; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D002951:Citrates / Q000652:urine*; D019343:Citric Acid; D004043:Dietary Fiber / Q000032:analysis; D006801:Humans; D007669:Kidney Calculi / Q000209:etiology* / Q000378:metabolism / Q000652:urine; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014556:Urine
D002951:Citrates; D004043:Dietary Fiber; D019343:Citric Acid; D002118:Calcium