Small cell carcinoma of the uterine cervix with neurosecretory granules associated with pregnancy. A case report.
An extremely rare case is reported of small cell carcinoma of the cervix with a fulminating course complicating pregnancy. The primary lesion was first noted in the 27-year old patient at 36 weeks of gestation. Cesarean section followed by radical hysterectomy with bilateral pelvic lymph node dissection was performed. Brain and breast metastases occurred two months after primary surgery, while adjuvant radiotherapy to the pelvis was ongoing. The patient died suddenly of massive tumor emboli in the brain. The microscopic and ultrastructural findings, immunohistochemical studies and flow cytometric analysis are presented.
Chang
D H
DH
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.
Hsueh
S
S
Soong
Y K
YK
D000328:Adult; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000628:therapy; D002585:Cesarean Section; D003594:Cytoplasmic Granules / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy