Protective effect of cisapride against indomethacin-induced obstruction of the gastric mucosal hemodynamics in rats.
We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin using an organ reflectance spectrophotometry system in rats. Indomethacin (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and the gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its therapeutic efficacy.
Yokoyama
T
T
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Kitazawa
T
T
Ishii
A
A
Ogihara
T
T
Sato
N
N
Karasawa
A
A
D000818:Animals; D020117:Cisapride; D004195:Disease Models, Animal; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D007213:Indomethacin / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D010100:Oxygen / Q000097:blood; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D013053:Spectrophotometry
D006454:Hemoglobins; D010880:Piperidines; D012702:Serotonin Antagonists; D010100:Oxygen; D020117:Cisapride; D007213:Indomethacin