Replicating and host-restricted non-replicating vaccinia virus vectors for vaccine development.
Vaccinia virus, effectively used for immunization against smallpox, now serves as a recombinant vector for the development of vaccines against other infectious agents and cancer. Recent advances have led to increased gene expression, enhanced immunogenicity, and greater safety. Both replicating and host-restricted non-replicating vectors are available.
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
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Moss
D003673:Defective Viruses / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D005822:Genetic Vectors; D016679:Genome, Viral; D011401:Promoter Regions, Genetic; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014616:Vaccinia virus / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D014779:Virus Replication
D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic