Changes in the liver, kidney and heart fatty acid composition following administration of ibuprofen to mice.
Crl:NMRI-BR male mice received 0.6 mg/day of ibuprofen (animal model for human dose 1200 mg/day) in the diet for a period of 6 weeks. This treatment resulted in increased body mass, liver mass, and total lipid content in the liver tissue. Changes in the fatty acid composition in the individual lipid classes were most important in kidney tissue; levels of polyunsaturated fatty acids were increased in phospholipids and decreased in neutral lipids. These changes were compensated for by opposite changes in the levels of saturated and monoenoic acids. Similar changes were also observed in liver and heart lipids. An increased level of an unusual component was observed in heart tissue, which was identified as isopropyl myristate by GC-MS and verified by comparing the mass spectra and retention times with those of synthetic standards.
Tvrzická
E
E
1st Faculty of Medicine, 4th Department of Medicine, Charles University, Prague, Czech Republic.
Cvrcková
E
E
Máca
B
B
Jirásková
M
M
D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006321:Heart / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology*; D007202:Indicators and Reagents; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
D005227:Fatty Acids; D007202:Indicators and Reagents; D014280:Triglycerides; D007052:Ibuprofen