Endothelin-C-terminal hexapeptide increases grooming in mice.
Grooming behavior has been considered a response to stress, and a number of stress-related peptides have been demonstrated to modulate grooming behavior. In the experiments reported here, endothelin-C-terminal hexapeptide containing amino acid residues 16-21, ET[16-21], increased grooming with a maximum effect at 0.75 microgram. ET[16-21] did not significantly alter eating or locomotor behavior. Both alpha-helical CRF (10 micrograms) and neuropeptide Y (1 microgram) inhibited the grooming produced by ET[16-21].
Geriatric Research, Education and Clinical Center, St. Louis VA Medical Center, MO 63106.
J
J
Scherrer
J E
JE
Morley
J F
JF
Flood
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D006120:Grooming / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009478:Neuropeptide Y / Q000494:pharmacology; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013268:Stimulation, Chemical
D016232:Endothelins; D009478:Neuropeptide Y; D010446:Peptide Fragments; C061533:endothelin (16-21); D003346:Corticotropin-Releasing Hormone