Factor VIII in blood plasma of haemophilic sheep: analysis of clotting time-plasma dilution curves.
The sheep haemophilia A, recently described in a flock of White Alpine sheep, is probably caused by the production of a less potent mutant of factor VIII (F-VIII). Other potential mechanisms, such as drastic reduction (or lack) of F-VIII production, or occurrence of an F-VIII inhibitor, are less likely. This conclusion was based on the analysis of plasma dilution-clotting effect relationships in normal female (anestrous, non-pregnant) sheep, female carriers of haemophilia A, and afflicted male sheep. A response model underlying the analysis was suggested, its validity tested, and a mathematical analysis suitable for routine evaluation procedure recommended.
Neuenschwander
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S
Department of Animal Science, ETH-Swiss Federal Institute of Technology, Zürich.
Pliska
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V
D000818:Animals; D001780:Blood Coagulation Tests / Q000379:methods; D005169:Factor VIII / Q000032:analysis* / Q000235:genetics; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000662:veterinary*; D008297:Male; D008954:Models, Biological; D017711:Nonlinear Dynamics; D012756:Sheep / Q000097:blood* / Q000235:genetics; D012757:Sheep Diseases / Q000097:blood*
D005169:Factor VIII