[Changes in the fatty acid composition of the phospholipids in the internal organs of rats during the modelling of aconitine arrhythmia].
The changes of phospholipid fatty acid composition of the viscera were investigated in a model of aconitinic arrhythmia in rats by the GC method. Aconitinic arrhythmia leads to a reduction in a proportion of polyenic fatty acids (arachidonic, docosahexaenoic) and to an increase in that of saturated acids (palmitic and stearic acids) in visceral phospholipids as a result of developed respiratory and circulatory hypoxia and to activation of lipid peroxidation. The most hypoxia-sensitive are phospholipids of the heart and brain, the least are renal phospholipids. The ratio of saturated to polyunsaturated fatty acids is the most informative value of lipid peroxidation in aconitinic arrhythmia.
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Skrupskiĭ
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Plaksin
D000157:Aconitine; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000378:metabolism*; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005227:Fatty Acids; D010743:Phospholipids; D000157:Aconitine
Izmenenie zhirnokislotnogo sostava fosfolipidov vnutrennikh organov krys pri modelirovanii akonitinovoĭ aritmii.