A gene for distal arthrogryposis type I maps to the pericentromeric region of chromosome 9.
Club foot is one of the most common human congenital malformations. Distal arthrogryposis type I (DA-1) is a frequent cause of dominantly inherited club foot. Performing a genomewide search using short tandem repeat (STR) polymorphisms, we have mapped a DA-1 gene to the pericentromeric region of chromosome 9 in a large kindred. Linkage analysis has generated a positive lod score of 5.90 at theta = 0, with the marker GS-4. Multiple recombinants bracketing the region have been identified. Analysis of an additional family demonstrated no linkage to the same locus, indicating likely locus heterogeneity. Of the autosomal congenital contracture disorders causing positional foot deformities, this is the first to be mapped.
Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84132-1001.
M
M
Bamshad
W S
WS
Watkins
R K
RK
Zenger
J F
JF
Bohnsack
J C
JC
Carey
B
B
Otterud
P A
PA
Krakowiak
M
M
Robertson
L B
LB
Jorde
D001176:Arthrogryposis / Q000145:classification / Q000235:genetics*; D002503:Centromere / Q000235:genetics*; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003025:Clubfoot / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D005819:Genetic Markers