In vivo stimulation of insulin release by succinic acid methyl esters.
Both the monomethyl and dimethyl esters of succinic acid, administered intravenously to fasted and anesthetized rats, caused a rapid increase in plasma insulin. A positive insulin secretory response to succinic acid monomethyl ester was also observed after intraperitoneal injection to fed and conscious rats. On a molar basis, stimulation of the insulin release, evoked by succinic acid esters, represented about twice that caused by D-glucose. It is speculated that succinic acid esters may be efficient insulin secretagogues even in those models of noninsulin-dependent diabetes characterized by a site-specific defect in the transport of D-glucose or in the early steps of its catabolism in the pancreatic B-cell.
Vicent
D
D
Fundacion Jimenez Diaz, Centro Asociado al Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
Villanueva-Penacarrillo
M L
ML
Malaisse-Lagae
F
F
Leclercq-Meyer
V
V
Valverde
I
I
Malaisse
W J
WJ
D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013386:Succinates / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D013386:Succinates; C056451:dimethyl succinate; D005947:Glucose; C041105:monomethyl succinate