Effect of desalivation on water and sodium chloride intake in rats.
Desalivate rats consumed significantly less water than sham-operated rats in response to acute challenges with a variety of dipsogens, including polyethylene glycol (PEG), isoproterenol, serotonin, and an angiotensin I converting enzyme inhibitor (CEI). Nonsignificant reductions were recorded after treatments with either angiotensin II or hypertonic NaCl. Meal-related hyperdipsia, and resultant possible hyperhydration, of desalivate rats does not account fully for these reductions in experimental thirsts. The mean 24-h intake of three concentrations of NaCl, in choice with water, showed no difference in the preferences for NaCl of desalivate and sham-operated animals. During chronic administration of CEIs, both desalivate and sham-operated rats showed comparable induction of NaCl appetite.
Department of Psychology, University of Florida, Gainesville 32611.
T M
TM
Nicholson
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Rowland
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004656:Enalapril / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012084:Renin-Angiotensin System / Q000187:drug effects; D012472:Salivation / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D012965:Sodium Chloride / Q000008:administration & dosage*; D013894:Thirst / Q000187:drug effects*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000804:Angiotensin II; D012701:Serotonin; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D004656:Enalapril; D007545:Isoproterenol