Malignancies in patients with cirrhosis: CT sensitivity and specificity in 200 consecutive transplant patients.
OBJECTIVE
To determine the sensitivity and specificity of computed tomography (CT) as a screening tool in patients with cirrhosis.


METHODS
CT examinations were performed before liver transplantation in 200 consecutive patients with cirrhosis. Scans were prospectively reviewed and compared with pathologic findings in the fresh serially sectioned whole livers.


RESULTS
Pathologic evaluation revealed hepatocellular carcinoma in 35 patients and cholangiocarcinoma in five. Malignancy was clinically suspected in 18 patients prior to imaging. CT depicted tumor in 25 patients; tumor was identified only at pathologic study in 14 patients. Sensitivity of unenhanced and enhanced CT in detection of malignancy was 63% and 68%, respectively, and specificity was 63% and 81%, respectively. Cysts and hemangiomas were found in only 10 and five patients, respectively.


CONCLUSIONS
CT is insensitive for detection of neoplasms in the cirrhotic liver. Unsuspected malignant neoplasms are encountered more frequently than cysts or hemangiomas. Sensitivity of unenhanced CT for tumor detection is similar to that of enhanced CT; unenhanced CT, however, is less specific for malignancy.
Department of Radiology, University of Pittsburgh Medical Center, PA 15213-2582.
W J
WJ
Miller
R L
RL
Baron
G D
GD
Dodd
M P
MP
Federle
D001650:Bile Duct Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D018281:Cholangiocarcinoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed