Evaluation of Salmonella porins as a broad spectrum vaccine candidate.
Porins were prepared from smooth strain of Salmonella typhi 0-901 and chemotype of rough mutant of S. typhimurium Ra-30. Mice were immunized with both the porin preparations in different groups and challenged with S. typhimurium LT2-71 and S. enteritidis SH-1269. Porin immunized mice showed significant protection (P < 0.01) against challenge with homologous as well as heterologous strains. Hence, the use of porins may be attempted in future to protect against salmonellosis.
Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
B
B
Tabaraie
B K
BK
Sharma
P R
PR
Sharma
R
R
Sehgal
N K
NK
Ganguly
D000818:Animals; D001428:Bacterial Vaccines; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D051379:Mice; D018272:Porins / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D014611:Vaccination
D001428:Bacterial Vaccines; D007106:Immune Sera; D018272:Porins