[Cytogenetic analyses on giant cell tumor of bone].
Over a 3 year period, 19 surgically resected giant cell tumors of bone and cell lines from 4 cases were analysed cytogenetically. The results indicate that most of the tumor cells are heteroploid, the chromosome model number is predominantly hypodiploid. Karyotypic analysis demonstrated that the loss of chromosome #17, #18 appears more frequently (with a loss rate of 60% and 45% respectively), terminal deletion and telomeric fusion were the most common cytogenetic aberrations. We compared highly nonrandom tumor cell chromosome breakpoints and the same patient's somatic cell chromosome fragile sites with published oncogenes and found that 7q32, 13q13, 22q12 were coincident with MET, FLT, YES2/PDGFB (sis) respectively. Whether these loci abnormalities correlate with tumorgenesis needs further investigation.
Department of Pathology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Q S
QS
Zhu
J S
JS
Qiu
D000782:Aneuploidy; D001859:Bone Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002886:Chromosomes, Human, Pair 17; D002887:Chromosomes, Human, Pair 18; D018212:Giant Cell Tumor of Bone / Q000235:genetics*; D006801:Humans; D009857:Oncogenes; D014407:Tumor Cells, Cultured