Frequency of renin gene restriction fragment length polymorphism in hypertensives with a genetic predisposition to hypertension.
The genetic basis of essential hypertension is still uncertain. Because renin is thought to be a candidate gene for essential hypertension, a prospective study was conducted to compare the frequency of renin gene HindIII restriction fragment length polymorphism (RFLP) in normotensive and hypertensive subjects without (HTG-) and with a genetic predisposition to essential hypertension (HTG+). The frequency of the 9.0-kb fragment was significantly (p < 0.05) higher in the HTG+ group than in the normotensive and HTG- groups. An association between renin RFLP and hypertension in man was shown for the first time. It is suggested that a gene for blood pressure regulation has been localized to a part of the genome close to, or identical to, the renin locus.
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
T
T
Morise
Y
Y
Takeuchi
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R
Takeda
D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011863:Radioimmunoassay; D012083:Renin / Q000235:genetics*
D012083:Renin