Association of autosomal loci with the grooming activity in mice observed in open-field.
We studied the reactions of mice when placed in an open-field environment and counted the grooming score in response to novelty. We used animals from Mendelian F2s and backcrosses, obtained from the parental strains ABP/Le and C57BL/6By, to test the hypothesis that the differences in this behavior were due to genetic variation at loci associated with visible recessive markers. Furthermore, the analysis of the segregating populations by means of non parametric Collins' method was used to test the one segregating unit hypothesis. We provide evidence for genes involved in the variation of grooming activity and situated close to the locus se on chromosome 9. Although the one-locus hypothesis was ruled out in the general analysis, a possible major gene effect in some crosses suggests a maternal environment effect.
URA CNRS 1294 - UFR Biomédicale des Saints-Pères, Université Paris V, France.
Y
Y
Clément
C
C
Adelbrecht
B
B
Martin
G
G
Chapouthier
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D014644:Genetic Variation; D006120:Grooming; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL