Scientific hypothesis: a new strategy for the design of anti-protozoal drugs--DNA polymerase as a drug target.
Chemotherapy against protozoan diseases has been practised since ancient times. Although still widely used, antiparasitic drugs are seldom completely effective. Complete elimination of an extensive protozoan infection usually requires a combination of drugs which target parasitic mechanisms very similar to the human host, as manifested by a multitude of side effects of varying severity. Furthermore, there is an escalating problem of widespread resistance to commonly used chemotherapeutic agents. Here we present an alternative strategy for the design of antiprotozoal agents using the principal enzyme involved in DNA replication as a possible drug target--DNA polymerase.
Biñas
M
M
Department of Microbiology, School of Biological and Biomedical Sciences, University of Technology, Sydney, Gore Hill, NSW, Australia.
Johnson
A M
AM
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004261:DNA Replication / Q000502:physiology; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics; D015195:Drug Design; D056890:Eukaryota / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D011528:Protozoan Infections / Q000188:drug therapy* / Q000517:prevention & control; D016052:Protozoan Vaccines
D000981:Antiprotozoal Agents; D016052:Protozoan Vaccines; D004259:DNA-Directed DNA Polymerase