Pharmacokinetic interaction between praziquantel and albendazole in Sudanese men.
It has been suggested that praziquantel (40 mg/kg) and albendazole (400 mg) administered together may have a synergistic effect on intestinal parasites. In the present study, the pharmacokinetics of these agents, alone and in combination, were investigated in the presence and absence of food in two groups of Sudanese males. The results indicated that praziquantel pharmacokinetics were not effected by co-administration of albendazole although, in the presence of food, the area under the curve (AUC(0-infinity)) of praziquantel increased 2.6 fold. The AUC(0-infinity) of albendazole sulphoxide (the active metabolite of albendazole) increased 4.5-fold when administered with praziquantel, eight-fold when given with food and 12-fold when given with praziquantel and food. The balance between the therapeutic efficacy of this combination of drugs and its safety profile needs to be studied, especially with regard to albendazole.
Faculty of Medicine, University of Khartoum, Sudan.
M
M
Homeida
W
W
Leahy
S
S
Copeland
M M
MM
Ali
D W
DW
Harron
D000328:Adult; D015766:Albendazole / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004357:Drug Synergism; D005215:Fasting / Q000097:blood; D005502:Food; D006801:Humans; D008297:Male; D011223:Praziquantel / Q000097:blood / Q000493:pharmacokinetics*; D013397:Sudan; D013997:Time Factors
D011223:Praziquantel; D015766:Albendazole