Deficit of [3H]L-689,560 binding to the glycine site of the glutamate/NMDA receptor in the brain in Huntington's disease.
Binding of [3H]L-689,560 to the glycine site of the glutamate/NMDA receptor was carried out using post-mortem brain tissue from patients with Huntington's disease (HD) and from matched controls. Decreased binding site density (by 62% in the caudate nucleus, 20% in the frontal cortex) was identified in HD. The deficit found in the caudate nucleus in HD correlated with deficits of GABA and glutamate concentrations and thus may reflect the ongoing disease process.
Reynolds
G P
GP
Department of Biomedical Science, University of Sheffield, UK.
Pearson
S J
SJ
Hutson
P H
PH
D000328:Adult; D000368:Aged; D000634:Aminoquinolines / Q000378:metabolism*; D001665:Binding Sites; D002102:Cadaver; D002421:Caudate Nucleus / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017470:Receptors, Glutamate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014316:Tritium
D000634:Aminoquinolines; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D014316:Tritium; C074617:4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline; D005998:Glycine