Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.
Previously, we showed that the M1 gene (encoding a viral core protein, mu 2, whose function is unknown) was associated with the efficiently myocarditic phenotype of a reovirus variant, 8B. Here, we have extended our genetic analysis of 8B and conducted genetic analyses of two other reovirus strains (T1L [serotype 1 strain Lang] and Abney). Our results demonstrate that multiple viral core proteins are determinants of reovirus-induced myocarditis. In contrast to our previous association of mu 2 with induction of myocarditis, this provides strong evidence that a core function achieved through the interaction of multiple core proteins is responsible for induction of the disease.
Department of Microbiology, Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
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Sherry
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Blum
D000818:Animals; D000831:Animals, Newborn; D005814:Genes, Viral; D014644:Genetic Variation; D016679:Genome, Viral; D051379:Mice; D008815:Mice, Inbred Strains; D009205:Myocarditis / Q000821:virology*; D010641:Phenotype; D012087:Reoviridae / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D014758:Viral Core Proteins / Q000235:genetics*
D014758:Viral Core Proteins