Cerebral proton magnetic resonance spectroscopic imaging in a neonate with tuberous sclerosis.
On the basis of detection of cardiac tumours and an intracerebral subependymal mass, the diagnosis of tuberous sclerosis was made in a fullterm neonate. To evaluate cerebral metabolism cerebral mass proton magnetic resonance spectroscopic imaging (1H-MRSI) was performed. A local decrease in N-acetyl-aspartate (NAA), and an increase in choline signals were found. Lactate could neither be demonstrated in the subependynal nodule, nor in the surrounding tissue, thereby rendering the possibility of a high-grade malignant tumour less likely. No major changes were found at 3 and 6 months of age. The present study demonstrates, that 1H-MRSI may be helpful in metabolic evaluation of cerebral masses in patients with tuberous sclerosis.
Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
F
F
Groenendaal
L C
LC
Meiners
R
R
Gooskens
L S
LS
de Vries
D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology; D006222:Hamartoma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D014402:Tuberous Sclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology