[The relation between the physicochemical structure and the anticoagulant effects of polysulfated chitosan derivatives].
Rabbit experiments have revealed that there is a relationship between the chemical structure and anticoagulative effects of polysulfated chitosan derivatives. Sixteen chitosan polymers with a polarization rate of 71 to 547 and substitution by sulfur from 0.62 to 1.86 which were intravenously injected showed heparin-like action. The anticoagulant activity of chitosan samples depended on the degrees of polymerization and sulfation. The most active (30-52 U/mg) and long-acting (250-350 min) products had a polymerization in the range 180-240 and sulfation no less than 1.5, the half-life being 37-50 min, and the elimination constant being 1.38.10(-2) to 1.88.10(-2)min-1.
Drozd
N N
NN
Sher
A I
AI
Makarov
V A
VA
Gal'braĭkh
L S
LS
Vikhoreva
G A
GA
Gorbacheva
I N
IN
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D048271:Chitosan; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D008297:Male; D008970:Molecular Weight; D010314:Partial Thromboplastin Time; D011817:Rabbits; D013329:Structure-Activity Relationship; D013997:Time Factors
D000925:Anticoagulants; D002686:Chitin; D048271:Chitosan
Sviaz' fiziko-khimicheskoĭ struktury i antikoaguliantnykh éffektov u proizvodnykh polisul'fatirovannogo khitozana.