[Comparison of 3 long ovarian stimulation protocols for in vitro fertilization using a delayed acting GnRH analogue].
Three long protocols of ovarian stimulation for IVF using long acting GnRH agonist and hMG were compared. 3 molecules were used: Triptoreline (Décapeptyl* 3.75 mg), gosereline (Zoladex*) and leuproreline (Enantone* 3.75 mg). Assigning of these 3 protocols were randomised. 63, 68 and 67 cycles of stimulation were studied. Results in term of pregnancy are the same in the 3 groups. Only a tendency of lower frequency of ovarian hyperstimulation in Décapeptyl 3.75 mg group is found, associated with less embryo and less cycles with cryopreservation of supernumeraries embryos (p = 0.1).
Service de gynécologie-obstétrique, CHU Pitié-Salpêtrière, Paris.
D
D
Vauthier-Brouzes
G
G
Lefebvre
D000328:Adult; D002985:Clinical Protocols; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D005260:Female; D005307:Fertilization in Vitro; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008596:Menotropins / Q000627:therapeutic use; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000453:epidemiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D017329:Triptorelin Pamoate; D017273:Goserelin; D008596:Menotropins; D016729:Leuprolide
Comparaison de 3 protocoles longs de stimulation ovarienne pour FIV utilisant un analogue retard du GnRH.