[Type and frequency of severe infectious complications in the treatment of acute leukemia. Prospectively acquired findings in a consecutive patient cohort].
139 patients with newly diagnosed acute leukemia were admitted to our institution from 1984 to 1990. More than 70% developed severe infections during cytotoxic chemotherapy. Septicemia accounted for 40.1%. The two most frequent organisms isolated from the blood were Staphylococcus epidermidis and E. coli. A prominent finding were the soft tissue infections (23.4%). They often occurred in the anorectal area and at the exit of an intravenous catheter. Pneumonia (17.8%) was of fungal origin in 22.9%. 66% of the infections occurred when the neutrophils were below 100/microliters.
Departement für Innere Medizin, Universitätsspital Zürich.
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B
Jud
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J
Gmür
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F
Follath
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy*; D015995:Prevalence; D011446:Prospective Studies; D018805:Sepsis / Q000453:epidemiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology; D013212:Staphylococcus epidermidis
Art und Häufigkeit schwerer Infektkomplikationen bei der Behandlung akuter Leukämien. Prospektiv erhobene Befunde eines konsekutiven Patientenkollektivs.