A comparison of the effects of buprenorphine, carprofen and flunixin following laparotomy in rats.
Rats underwent a midline laparotomy and received buprenorphine, buprenorphine together with carprofen, flunixin or carprofen alone while a control group received saline. Food and water intakes and body weight were reduced following surgery in the saline control group. The degree of depression of these variables was significantly reduced by the administration of either buprenorphine or carprofen. In all groups of rats locomotor activity was depressed following surgery. Analgesic administration had little influence on these changes in activity, although administration of two doses of buprenorphine (0.05 mg/kg, 9 h interval) reduced the degree of depression in comparison to the saline control group. If the depression in food and water consumption is related to the presence of post-operative pain, then these findings suggest that analgesics should be administered to rats following surgical procedures.
Comparative Biology Center, Medical School, Newcastle upon Tyne, UK.
J H
JH
Liles
P A
PA
Flecknell
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001835:Body Weight; D002047:Buprenorphine / Q000494:pharmacology*; D002227:Carbazoles / Q000494:pharmacology*; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects; D004359:Drug Therapy, Combination; D004435:Eating / Q000187:drug effects; D007813:Laparotomy; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C014557:flunixin; D002047:Buprenorphine; C007005:carprofen; D003002:Clonixin