Localization of the Tp53 gene on Syrian hamster chromosome 9 by fluorescence in situ hybridization.
Mutations of the Tp53 tumor suppressor gene have been detected in 50% of all human cancers. The normal Tp53 gene product acts as a negative regulator of cell division or is associated with abnormal growth in certain differentiated cell types. The Tp53 gene was mapped by FISH to Syrian hamster chromosome 9 bands qb2.2-->2.3 using a genomic DNA probe with a high degree of sequence identity to the human Tp53 gene.
Popescu
N C
NC
Laboratory of Biology, National Cancer Institute, Bethesda, MD.
Zimonjic
D B
DB
Albor
A
A
Notario
V
V
D000818:Animals; D002874:Chromosome Mapping; D003360:Cosmids; D006224:Cricetinae; D015342:DNA Probes; D015723:Gene Library; D016158:Genes, p53; D017404:In Situ Hybridization, Fluorescence; D008647:Mesocricetus / Q000235:genetics*
D015342:DNA Probes