Doxorubicin and DNA minor groove-binding oligopeptide conjugates as anticancer agents.
Doxorubicin (Dor) and DNA minor groove-binding oligopeptide conjugates have been synthesized and their antitumor activities tested in vitro against KB cells. These new Dor analogues are less toxic to KB cells than the parent Dor.
Palo Alto Institute of Molecular Medicine, Mountain View, CA 94043.
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Y
Wang
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L
Huang
S C
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Wright
J W
JW
Larrick
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009842:Oligopeptides; D004317:Doxorubicin; D004247:DNA