Efficacy and tolerance of low-dose loop diuretics in hypertension.
Prospective studies have emphasized the key role for diuretics in the treatment of high blood pressure. Short-acting loop diuretics have not achieved the same acceptance as the thiazides in treatment of hypertension. Newer long-acting compounds, however, such as torasemide, have now been found to be as efficacious as the thiazides, particularly as they can be given once daily and have a low side-effect profile. Adverse laboratory side-effects are rare in hypertensive patients treated with torasemide; carbohydrate intolerance, dyslipidaemia, or hypokalaemia have seldom been observed during its long-term administration. For these reasons, torasemide is therapeutically attractive due to its antihypertensive efficacy with once-daily administration, low incidence of adverse side-effects, and sustained improvement of the cardiovascular risk profile.
Schmieder
R E
RE
4 Medizinische Klinik/Nephrologie, Universität Erlangen-Nürnberg, Germany.
Rockstroh
J K
JK
D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004361:Drug Tolerance; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008138:Loop of Henle / Q000187:drug effects; D013449:Sulfonamides / Q000627:therapeutic use; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D000077786:Torsemide