Deficiency of acyl CoA cholesterol acyl transferase activity in suncus liver.
We reported previously that apolipoprotein B is not actively secreted from suncus liver. In the present study we have investigated the hepatic cholesterol metabolism, which plays a critical role in the secretion of apo B. We found that the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in suncus liver is high and that acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity is almost absent in contrast to rats. As a result, the hepatic content of cholesterol ester, upon which apoprotein B secretion partly depends, is very low in suncus. The deficiency of ACAT activity may cause the defect in active secretion of apoprotein B-containing lipoproteins in suncus.
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo.
A
A
Nagayoshi
N
N
Matsuki
H
H
Saito
K
K
Tsukamoto
M
M
Wakashima
M
M
Kinoshita
M
M
Yamanaka
T
T
Teramoto
D000818:Animals; D003411:Arvicolinae / Q000378:metabolism*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar / Q000378:metabolism*; D002785:Sterol O-Acyltransferase / Q000172:deficiency*
D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase