Design of potential angiogenin inhibitors.
A model of angiogenin has been prepared by homology modelling, based upon the structure of ribonuclease A. This model has been used to postulate an inhibitor based upon the angiostatic agent TAN1120. The complex of ribonuclease A with a dinucleotide has been modelled and used as a guide to the binding orientation of daunomycin--the closest TAN1120 analogue for which the crystal structure and stereochemistry are available.
Department of Chemistry, University of Surrey, Guildford, U.K.
B J
BJ
Howlin
N P
NP
Tomkinson
J
J
Chen
G A
GA
Webb
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D001665:Binding Sites; D002417:Cattle; D003198:Computer Simulation; D003630:Daunorubicin / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012259:Ribonuclease, Pancreatic / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D011506:Proteins; C081412:TAN 1120; C046366:angiogenin; D012259:Ribonuclease, Pancreatic; D003630:Daunorubicin