Treatment of peritoneal carcinomatosis by intraperitoneal chemo-hyperthermia: reliable and unreliable concepts.
Intraoperative peritoneal chemo-hyperthermia (IPCH) is a promising treatment of peritoneal carcinomatosis arising from digestive tumors. After presenting the rationale for the use of IPCH, this review reports the results published to date by different groups. Unfortunately, data with respect to technical aspects, indications and results are unclear, inhomogeneous and questionable. The discussion presents reliable and unreliable points, mainly concerning the technical aspects of IPCH: what is the maximal desirable tumor thickness before initiating treatment? What is the ideal temperature? Is central hyperthermia beneficial? What is the ideal duration? What is the most effective antimitotic drug? A new classification of peritoneal seeding before cytoreductive surgery and before the initiation of IPCH, is proposed, and a suggestion concerning the reporting of drug concentrations made. Numerous prospective studies need to be conducted to test different technical modalities and to evaluate the results of IPCH.
Department of Oncologic Digestive Surgery, Institute Gustave Roussy, Cancer Center Hospital, Villejuif, France.
D
D
Elias
B
B
Detroz
B
B
Debaene
E
E
Damia
B
B
Leclercq
P
P
Rougier
P
P
Lasser
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D004357:Drug Synergism; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007430:Intraoperative Care; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D013696:Temperature; D016896:Treatment Outcome
D000970:Antineoplastic Agents