Electrospray mass spectrometry study of metal ions in matrilysin. Evidence that two zincs and two calciums are required for inhibitor binding.
Yuan
Z
Z
Syntex Research, Canada, Mississauga, Ontario.
Feng
R
R
Castelhano
A
A
Billedeau
R
R
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000032:analysis* / Q000378:metabolism; D007700:Kinetics; D008322:Mammals; D013058:Mass Spectrometry / Q000379:methods; D020783:Matrix Metalloproteinase 7; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D008970:Molecular Weight; D015032:Zinc / Q000032:analysis* / Q000378:metabolism
D008666:Metalloendopeptidases; D020783:Matrix Metalloproteinase 7; D015032:Zinc; D002118:Calcium