Novel bioactive diterpenoids from Aframomum aulacocarpos.
Three new labdane diterpenes, 12 alpha,17-epoxy-3 beta-hydroxy-8(9),13- labdadien-16,15-olide (aulacocarpinolide) [1], methyl 8 beta,17:14 zeta,15-diepoxy-3 beta-hydroxy- 12E-labden-16-oate (aulacocarpin A) [2], and methyl 8 beta,17:14 zeta,15-diepoxy-3 beta,6 beta- dihydroxy-12E-labden-16-oate (aulacocarpin B) [3] have been isolated from the Cameroonian spice, Aframomum aulacocarpos, and their structures elucidated using spectroscopic techniques. The known bioactive diterpene dialdehyde, 8 beta,17-epoxy-12E-labdene-15,16-dial (aframodial) [4] was also isolated. Compounds 1-3 showed weak antimicrobial and cytotoxic activities.
Department of Organic Chemistry, University of Yaoundé, Cameroon.
J F
JF
Ayafor
M H
MH
Tchuendem
B
B
Nyasse
F
F
Tillequin
H
H
Anke
D000349:Africa; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D010944:Plants / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D004224:Diterpenes