Normal CAG repeat length in the Huntington's disease gene in senile chorea.
There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths were normal. These findings support senile chorea as being a distinct clinical entity that is nosologically separate from late-onset HD.
Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.
H
H
Shinotoh
D B
DB
Calne
B
B
Snow
M
M
Hayward
B
B
Kremer
J
J
Theilmann
M R
MR
Hayden
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D005260:Female; D005796:Genes; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid
D004247:DNA