Dapsone attenuates kainic acid-induced seizures in rats.
We tested the ability of dapsone (4,4'-diamino-diphenyl sulfone) to attenuate kainic acid-induced seizures. We observed that 9.375 and 12.5 mg/kg doses of dapsone administered 30 min before a single kainic acid (10 mg/kg) i.p. injection were able to decrease the time of electroencephalographic seizures by 52% and 82%, respectively, as compared with rats administered with 10 mg/kg kainic acid only. The 12.5 mg/kg dose of dapsone was also able to diminish both kainic acid-evoked body and head shakes (58%) and kainic acid-induced mortality (75%). These results suggest that dapsone could be used in clinical trials as anticonvulsant.
Altagracia
M
M
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Mexico DF, Mexico.
Monroy-Noyola
A
A
Osorio-Rico
L
L
Kravzov
J
J
Alvarado-Calvillo
R
R
Manjarrez-Marmolejo
J
J
Ríos
C
C
D000818:Animals; D003622:Dapsone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D013239:Stereotyped Behavior / Q000187:drug effects
D003622:Dapsone; D007608:Kainic Acid