Production of cladospirone bisepoxide, a new fungal metabolite.
Cladospirone bisepoxide (1), a novel metabolite, was isolated from cultures of a fungus which was characterized as a coelomycete by the formation of pycnidia. By optimization of media and fermentation conditions, a titer of up to 1.5 g/liter on shake level and 1.16 g/liter on bioreactor scale could be achieved. The isolation of the compound was performed by solvent extraction of the culture broth and subsequent crystallization. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations.
Biotechnology Research Laboratories, CIBA-GEIGY Limited, Basel, Switzerland.
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Petersen
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Moerker
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Vanzanella
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Peter
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001419:Bacteria / Q000187:drug effects; D002963:Cladosporium; D003470:Culture Media; D004147:Dioxins / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D018525:Germination / Q000187:drug effects; D003904:Mitosporic Fungi / Q000378:metabolism*; D013141:Spiro Compounds / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D004147:Dioxins; D013141:Spiro Compounds; C090477:cladospirone bisepoxide