Recombinant Salmonella vectors in vaccine development.
A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.
Curtiss
R
R
Washington University, Department of Biology, St. Louis, MO.
Kelly
S M
SM
Tinge
S A
SA
Tacket
C O
CO
Levine
M M
MM
Srinivasan
J
J
Koopman
M
M
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D005798:Genes, Bacterial; D005818:Genetic Engineering; D005822:Genetic Vectors; D006801:Humans; D012475:Salmonella / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D012480:Salmonella Infections / Q000517:prevention & control*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D017384:Sequence Deletion; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000276:immunology; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology; D014774:Virulence
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic