Remission of proteinuria following correction of hyperlipidemia in NIDDM patients with nondiabetic glomerulopathy.
OBJECTIVE
Animal studies suggest that hyperlipidemia may play a direct role in glomerular damage. In patients with non-insulin-dependent diabetes mellitus (NIDDM), dyslipidemia occurs early in the course of nephropathy and may be involved in the progression of renal disease.


METHODS
We report on two young NIDDM patients with marked hyperlipidemia and proteinuria, in whom renal biopsy demonstrated nondiabetic glomerulopathy. In both cases, the decrease in blood lipid levels was associated with a major decrease in proteinuria. Episodes of hyperlipidemia were associated with a resumption of heavy proteinuria in one patient with serum triglyceride levels and proteinuria being closely correlated.


CONCLUSIONS
These two cases suggest that hyperlipidemia has an important role in the pathogenesis of glomerular disease.
Dubois
D
D
Service de Médecine Interne, Hôpital Lariboisière, Paris, France.
Chanson
P
P
Timsit
J
J
Chauveau
D
D
Nochy
D
D
Guillausseau
P J
PJ
Lubetzki
J
J
D000328:Adult; D000818:Animals; D001706:Biopsy; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000473:pathology; D018753:Diet, Protein-Restricted; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000473:pathology*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000378:metabolism; D007668:Kidney / Q000473:pathology; D008297:Male; D011507:Proteinuria; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol