YAC vectors. Humanizing the mouse genome.
The ability to replace mouse genes with their human equivalents using "yeast artificial chromosome" technology provides a powerful new technique for studying the regulation and function of human genes.
Jakobovits
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Department of Molecular Immunology, Cell Genesys Inc., Foster City, California 94404.
D000818:Animals; D002459:Cell Fusion; D018244:Chromosomes, Artificial, Yeast; D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000235:genetics*; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D051379:Mice / Q000196:embryology; D008822:Mice, Transgenic / Q000235:genetics*; D011995:Recombination, Genetic; D013234:Stem Cells / Q000166:cytology; D014162:Transfection
D004274:DNA, Recombinant