Short communication on erythrocyte membrane stabilization by decamethonium and succinylcholine.
The effects of decamethonium and succinylcholine on hypotonic haemolysis of erythrocytes were studied. These drugs at concentrations of 5 x 10(-8) M to 10(-4) M caused a dose dependent inhibition of haemolysis of erythrocytes in 0.45 pc NaCl but lysis occurred when the drug concentrations were increased to 10(-3) M. These results indicate that decamethonium and succinylcholine may have a membrane stabilization-lysis effect on erythrocytes.
Effraim
K D
KD
Department of Pharmacology, College of Medical Sciences, University of Maiduguri, Borno State, Nigeria.
Ahmad
K
K
D003650:Decamethonium Compounds / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005069:Evaluation Studies as Topic; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007038:Hypotonic Solutions; D013390:Succinylcholine / Q000494:pharmacology*
D003650:Decamethonium Compounds; D007038:Hypotonic Solutions; C033019:decamethonium; D013390:Succinylcholine