Adaptation of HIV-1 to pigtailed macaques.
In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV-1. T lymphocytes from pigtailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV-1 isolates were unable to productively infect pigtailed macaque cells. Inoculation of autologous, HIV-1 expressing cells led to establishment of persistent infection in pigtailed macaques as evidenced by recovery of infectious virus and development of virus-specific antibody responses.
Henry M. Jackson Foundation Research Laboratory, Rockville, MD 20850.
S
S
Gartner
Y
Y
Liu
V
V
Polonis
M G
MG
Lewis
W R
WR
Elkins
E A
EA
Hunter
J
J
Miao
K J
KJ
Corts
G A
GA
Eddy
D000064:Acclimatization; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D017931:DNA Primers; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis; D015750:Genes, gag; D015483:HIV Antibodies / Q000032:analysis / Q000096:biosynthesis; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008254:Macaca nemestrina; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*; D014764:Viral Proteins / Q000032:analysis / Q000096:biosynthesis
D017931:DNA Primers; D004279:DNA, Viral; D015483:HIV Antibodies; D014764:Viral Proteins