[The polymorphism of the tandem repeats in the dystrophin gene in the Ukrainian population].
The genetic heterogeneity of populations of different regions of Ukraine was studied using four polymorphic LNA sequences (GTAA-tandem repeats from the 3'-untranslated region of the dystrophin gene, the polymorphic systems pERT87-15--BamHI, pERT8718--TaqI, and pERT87-15--XmnI of the pERT locus of human chromosome X). We analyzed 500 DNA samples of healthy donors from the Kiev, Lvov, Poltava, and Lugansk regions. The above-mentioned polymorphic DNA sequences were used as markers to determine genetic distances between the regional populations of Ukraine. The data obtained indicate the existence of significant genetic differences among the regional populations of Ukraine. DNA polymorphism in the pERT87-8--TaqI system contributes the most significantly to these differences.
Livshits
L A
LA
Grishko
V I
VI
Maliarchuk
S G
SG
Kravchenko
S A
SA
D000483:Alleles; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D016189:Dystrophin / Q000235:genetics*; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012016:Reference Values; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014455:Ukraine; D014960:X Chromosome / Q000235:genetics
D016189:Dystrophin; D004247:DNA
Polimorfizm tandemnykh povtorov gena distrofina v populiatsii naseleniia Ukrainy.