Effects of exercise training on alpha-adrenergic mediated pressor responses and baroreflex function in older subjects.
Endurance exercise training increases maximal O2 uptake (VO2max) in older subjects, and training also improves cardiac function in older men. Although the effects of training on beta-adrenergic responses have been investigated, little information is available regarding the effects of alpha-adrenergic responses and baroreflex function in older men and women. The purpose of the study was to determine whether endurance exercise training can affect alpha-adrenergic responses and baroreflex function in the elderly. We studied 13 men and women, 63 +/- 4 yrs old (mean +/- SE). VO2max was determined during treadmill exercise. Baroreflex function was determined from the change in heart rate (HR) relative to the change in systolic blood pressure (delta HR/delta SBP) during infusion of phenylephrine. VO2max was increased by 23% (1.9 +/- 0.16 vs 2.34 +/- 0.20 l/min; p < .01) in response to training. Maximal heart rate did not change, but HR during submaximal exercise at the same absolute exercise intensity was 17% lower after training. Resting heart rate was slower in the trained state. During alpha-adrenergic stimulation induced by graded doses of phenylephrine infusion, heart rate was lower after training because of training-induced bradycardia at rest. However, the elevation in systolic blood pressure (delta SBP) and mean blood pressure (delta MBP) from basal levels in response to a given dose of phenylephrine were significantly larger (delta SBP:18 +/- 3 vs 26 +/- 3 mmHg, p < .01; and delta MBP 10 +/- 2 vs 15 +/- 3 mmHg, p < .01) after than before training.(ABSTRACT TRUNCATED AT 250 WORDS)
Spina
R J
RJ
Section of Applied Physiology, Washington University School of Medicine, St. Louis.
Bourey
R E
RE
Ogawa
T
T
Ehsani
A A
AA
D000368:Aged; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D010807:Physical Endurance / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D012119:Respiration / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine