Apoptosis in normal tissues induced by 5-fluorouracil: comparison between bolus injection and prolonged infusion.
The induction of apoptosis in normal tissues was histopathologically examined in rats treated with 5-fluorouracil (5-FU). 5-FU was administered by either bolus intravenous injection or 72-hr prolonged intravenous infusion (PIF). Bolus injection and PIF of 5-FU induced different kinetic profiles of apoptosis in the thymus, spleen and ileum. The bolus injections of 5-FU induced a greater extent of apoptosis in these tissues, compared to PIF 5-FU. These data indicate that the kinetics and extent of apoptosis induced by 5-FU depends on the schedule of the 5-FU administration, and that 5-FU-induced toxicity may be related to 5-FU-induced apoptosis in normal tissues.
Sakaguchi
Y
Y
Department of Internal Medicine, University of Texas Medical School, Houston 77225.
Stephens
L C
LC
Makino
M
M
Kaneko
T
T
Strebel
F R
FR
Danhauser
L L
LL
Jenkins
G N
GN
Bull
J M
JM
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology*; D007082:Ileum / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D005472:Fluorouracil