Cardiovascular effect of a naphthylmethyl substituted tetrahydroisoquinoline, YS 49, in rat and rabbit.
A novel tetrahydroisoquinoline, 1-alpha-naphthylmethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline (YS 49) 1) increased heart rate and force in isolated rat atria; 2) relaxed PE- and KCl-contracted rat aorta, and 3) decreased blood pressure and increased heart rate in anesthetized rabbit. These effects were blocked by propranolol, a nonselective beta-antagonist, but not by phentolamine, an alpha-blocker, and/or depletion of catecholamine by reserpine. These results suggest that the mechanism of action of YS 49 is due, at least in part, to beta-adrenergic receptor stimulation.
Department of Pharmacology, College of Medicine, Gyeongsang National University, Chinju, Korea.
Y S
YS
Lee
C H
CH
Kim
H S
HS
Yun-Choi
K C
KC
Chang
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D044005:Tetrahydroisoquinolines
D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C090309:YS 49; D010656:Phenylephrine; D011189:Potassium Chloride; D012110:Reserpine; D011433:Propranolol; D010646:Phentolamine