Mechanisms of intracellular protein transport.
Recent advances have uncovered the general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocytosis of hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats which then dissociate upon GTP hydrolysis. Both vesicles and their acceptor membranes carry targeting proteins which interact specifically to initiate docking. A general apparatus then assembles at the docking site and fuses the vesicle with its target.
Rothman
J E
JE
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D018699:Coated Vesicles / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism; D008561:Membrane Fusion / Q000502:physiology; D015388:Organelles / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D011506:Proteins