Studies of axonal regeneration in C57BL/6J and A/J mice.
The genetic and biological nature of a deficiency in axonal regeneration in C57BL/6J mice was investigated. From analysis of recombinant inbred strains, the genetic basis for the deficient regeneration behaviours of C57BL/6J and A/J mice is deduced to involve multiple loci. The defect in axonal regeneration in C57BL/6J mice appears to be a delay rather than permanent impairment and appears to involve sensory more than motor axons.
Division of Neurosurgery, McGill University, Montreal, Que., Canada.
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D000818:Animals; D001369:Axons / Q000502:physiology*; D007002:Hypoglossal Nerve / Q000502:physiology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009046:Motor Neurons / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D010543:Peroneal Nerve / Q000166:cytology / Q000502:physiology; D011995:Recombination, Genetic; D013045:Species Specificity