Interleukin-6 as a marker of hepatic metabolism following hepatectomy.
This study evaluated the clinical significance of interleukin-6 levels after hepatectomy. Thirty-one patients who underwent hepatectomies were examined. Perioperative data involving serum laboratory tests, serum concentrations of interleukin-6, and liver energy status as indicated by arterial ketone body ratio (AKBR) were analyzed. In each patient, the maximum concentration of interleukin-6 in the postoperative course (IL-6-M) was observed by the 2nd postoperative day. IL-6-M correlated significantly with the maximum concentration of total bilirubin and with the postoperative decrease in AKBR. IL-6-M also correlated with the duration of surgery and blood loss, but no relationship with aminotransferase was found. We conclude that after hepatectomy IL-6-M may be a marker for the metabolic status of the liver as well as operative stress, and is useful because it can be evaluated in the early postoperative period.
Maruyama
H
H
Department of Surgery II, Nagoya University School of Medicine, Tsuruma, Japan.
Harada
A
A
Kurokawa
T
T
Nonami
T
T
Nakao
A
A
Takagi
H
H
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006498:Hepatectomy; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013997:Time Factors
D015415:Biomarkers; D015850:Interleukin-6; D007657:Ketone Bodies; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin