Seven-year follow-up of patients with duodenal ulcer disease.
BACKGROUND
The activity of duodenal ulcer disease varies not only between patients but also from time to time within patients, and earlier studies have concluded that the disease 'burns out' in many cases. It was the aim of this study to examine duodenal ulcer disease activity over a long period, to determine whether the degree of activity is stable within the individual patient.


METHODS
A cohort of 145 patients with a first-time duodenal ulcer diagnosed in our department between 1980 and 1985 were followed up for 7 years. The patients' self-reported use of acid-inhibitory drugs was taken as a measure of disease activity.


RESULTS
Twenty-eight per cent of the patients had no or minimal ulcer symptoms during the 7 years after healing of the index ulcer, whereas 13% had maximal activity with frequent or continuous use of acid-inhibitory drugs every year or ulcer surgery. A total of 11 patients were operated on because of severe ulcer symptoms or complications to the ulcer disease. The disease activity during the first 2 years after diagnosis did not change much during the following 5 years in most of the patients.


CONCLUSIONS
The course of duodenal ulcer disease during the first 2 years after diagnosis was a predictor of the long-term prognosis with a predictive value of approximately 70%, which may be considered satisfactory for decision-making in some clinical situations.
Dept. of Gastroenterology, Glostrup University Hospital, Denmark.
L
L
Kayser
B
B
Møller
K
K
Harting
S J
SJ
Rune
D004381:Duodenal Ulcer / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery; D005500:Follow-Up Studies; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors
D006635:Histamine H2 Antagonists; D009853:Omeprazole