[Evaluation of the influence of extrapancreatic factors (undernutrition, cirrhosis) on utilization of amino acids by the pancreas after its stimulation with secretin and cerulein].
We studied the utilization of amino acids by the pancreas after its hormonal stimulation in diseases in which disturbances occur of amino acid and protein metabolism. After 45 minutes of intravenous infusion of secretin (1 CU/kg) and cerulein (75 ng/kg) we found a significantly lower (p 0.05) decrease of amino acid concentration than in healthy individuals, both in chronic pancreatitis and in undernutrition and post-inflammatory cirrhosis with decompensation of liver function. Greatest disturbances in amino acid utilization by the pancreas were found in the case of valine, leucine and isoleucine. The results of studies show certain limitations in the use of this method for the assessment of the exocrine function of the pancreas.
Kliniki Chorób Metaboliczych i Gastroenterologii Instytutu Zywności i Zywienia w Warszawie.
M
M
Jarosz
J
J
Dzieniszewski
W
W
Kłys
H
H
Kunachowicz
D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D002108:Ceruletide / Q000494:pharmacology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010195:Pancreatitis / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology*
D000596:Amino Acids; D012633:Secretin; D002108:Ceruletide
Ocena wpływu pozatrzustkowych czynników (niedozywienie, marskość watroby) na zuzytkowanie aminokwasów przez trzustke po jej stymulacji sekretyna i ceruleina.