[Argyrophilic proteins in the nucleolar organizer in the differential diagnosis of cervical dysplasias and cancer].
Prospects of using the nucleolar organizer region (NOR) identification by silver nitrate for the diagnosis of dysplasias and cervical cancer were studied. Four groups of patients (22 cases) have been examined: group 1 (7 cases)--unchanged endocervical epithelium, group 2 (6 cases)--dysplasia of cervical epithelium of degree II-III, group 3 (3 cases)--carcinoma in situ, group 4 (6 cases)--invasive squamous cell nonkeratinizing carcinoma. The investigation showed that there are reliable differences in the quantity of silver granules per nucleus and also of NOR index between normal ectocervical epithelium and dysplasia, normal ectocervical epithelium and cancer, dysplasia and cervical cancer. The data obtained suggest that NOR argyrophilia may be a diagnostic marker of the tumor malignancy degree.
Diadyk
E A
EA
Vasilenko
I V
IV
Smirnova
E A
EA
Raĭkhlin
N T
NT
D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism; D002584:Cervix Uteri / Q000378:metabolism / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D009697:Nucleolus Organizer Region / Q000378:metabolism*; D016622:Silver Staining; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D009687:Nuclear Proteins
Izuchenie argirofil'nykh belkov iadryshkovogo organizatora pri differentsial'noĭ diagnostike displaziĭ i raka sheĭki matki.