[Development of analytical methods for the determination of Indosol and eyedrops].
Indosol is the water soluble Trometamol salt of Indomethacin. It shows promise in the combating of inflammations e.g. in ocular surgery. This paper reports on the results obtained using analytical methods of the Hungarian Pharmacopeia and the development of new analytical methods for Indosol. Solvent residues in Indosol were determined gas chromatographically after extraction with carbon tetrachloride, and an HPLC method was developed for the determination of Indosol as a pure substance or in eye-drops, using a Hypersil-ODS column and methanol-water-acetonitrile-acetic acid (55:35:10:5).
Vajda
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M
MTA Központi Kémiai Kutató Intézete, Budapest.
Horváthné Otta
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K
Forgácsné Tóth
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E
D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006814:Hungary; D007213:Indomethacin / Q000032:analysis*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D010602:Pharmacopoeias as Topic; D012997:Solvents
D009883:Ophthalmic Solutions; D012997:Solvents; D007213:Indomethacin
Az indosol hatóanyag és szemcsepp analitikai módszereinek kifejlesztése.