Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo.
An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation in the hippocampus of rats. Intraperitoneal injections of the drug markedly increased the degree and duration of long-term potentiation; similar results were obtained with an analogue of 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine that was also found to improve retention of memory in a radial maze task and in an odor-matching problem. These results define tools for enhancing long-term potentiation in vivo and confirm an important prediction from the hypothesis that long-term potentiation is a substrate of memory.
New York University, Center for Neural Science, NY 10003.
U
U
Stäubli
Y
Y
Perez
F B
FB
Xu
G
G
Rogers
M
M
Ingvar
S
S
Stone-Elander
G
G
Lynch
D000818:Animals; D001812:Blood-Brain Barrier; D004149:Dioxoles / Q000493:pharmacokinetics / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists; D005971:Glutamates / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects*; D010880:Piperidines / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D004149:Dioxoles; D018690:Excitatory Amino Acid Agonists; D005971:Glutamates; D010880:Piperidines; C085415:1-(1,3-benzodioxol-5-ylcarbonyl)piperidine