[Prognostic factors in the course of kidney transplantation].
The success rate of kidney transplants is influenced by many factors. Analysis of the largest available collection of transplant data shows a statistical influence of HLA compatibility, immunosuppression with cyclosporin, donor age, preservation solution with preservation times longer than 24 h, and prophylactic treatment with anti-CMV immunoglobulin in transplants from CMV-positive donors to CMV-negative recipients. Type and duration of pretransplant dialysis and recipient age were not shown to have a significant influence. These results demonstrate that the analysis of retrospective data allows a quantitative estimation of the influence of risk factors. This knowledge can be utilized prospectively to improve the transplant success rate.
Abteilung Transplantations-Immunologie, Universität Heidelberg.
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Opelz
D000293:Adolescent; D000328:Adult; D000368:Aged; D002102:Cadaver; D002423:Cause of Death; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology / Q000401:mortality*; D006085:Graft Survival / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000276:immunology / Q000401:mortality; D009926:Organ Preservation; D006435:Renal Dialysis; D012307:Risk Factors; D015996:Survival Rate
D016572:Cyclosporine
Prognostische Faktoren für den Verlauf nach Nierentransplantation.