Miconazole as inflammatory agent--I. Cellular and pathophysiological effects.
1. Subcutaneous injection of miconazole into the rat paw evoked an acute, circumscribed and long-lasting inflammation. 2. Miconazole edema presented two defined phases of rapid swelling. 3. Miconazole edema was antagonized by chlorpheniramine, dexamethasone and phenylbutazone. 4. This edema was 1.5-2 times more intense than edema due to econazole. 5. It is suggested that miconazole paw edema might be useful in the process of screening anti-inflammatory drugs.
Department of Pharmacology, Universidade de São Paulo, Brazil.
S
S
Hanada
J A
JA
Sertié
E
E
Waisbich
L S
LS
Sudo
D000818:Animals; D004487:Edema / Q000139:chemically induced; D007249:Inflammation / Q000139:chemically induced*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008825:Miconazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008825:Miconazole