New neplanocin analogues. IV. 2-Fluoroneplanocin A: an adenosine deaminase-resistant equivalent of neplanocin A.
2-Fluoro- and 2-chloroneplanocin A's (2 and 3) were synthesized as an adenosine deaminase resistant-equivalent of neplanocin A, and evaluated for their antitumor and antiviral activities. Of these, 2 was completely resistant to adenosine deaminase and showed more significant antitumor and antiviral activities than neplanocin A.
Shuto
S
S
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Obara
T
T
Itoh
H
H
Kosugi
Y
Y
Saito
Y
Y
Toriya
M
M
Yaginuma
S
S
Shigeta
S
S
Matsuda
A
A
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004351:Drug Resistance; D005354:Fibrosarcoma / Q000188:drug therapy*; D051379:Mice; D012328:RNA Viruses / Q000187:drug effects*; D012254:Ribavirin / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D012254:Ribavirin; C031096:neplanocin A; D000243:Adenosine Deaminase; D000241:Adenosine