Embolization of experimentally created aneurysms with intravascular stent devices.
OBJECTIVE
To assess the effectiveness of self-expanding, cobalt-alloy stents in the treatment of aneurysms in a canine model and to observe the pattern of blood flow and formation of fibrotic scar tissue.


METHODS
Porous metallic stents were endovascularly placed across the necks of experimentally created side aneurysms in the carotid arteries of three dogs; aneurysms were also created in the opposite carotid arteries in these animals to serve as controls.


RESULTS
Before stent placement, angiography of the carotid arteries demonstrated whirl-like, vortex flow of blood within the lumens of the aneurysms. Inflow was seen along the distal aneurysm wall; outflow was demonstrated along the proximal wall; slower vortex flow was present in the central lumen. Immediately after stent placement there was disruption of the usual vortex flow with stasis of contrast media and blood within the lumen. Inflow and outflow patterns were no longer seen. Complete ablation of these aneurysms was evident at follow-up angiographic studies--1 week, 1 month, and 2 months after stent placement. The stented carotid arteries remained widely patent; control aneurysms and carotid arteries were patent and unchanged. Histopathologic analysis revealed fibrotic reactive scar tissue completely filling the stented aneurysm pouches.


CONCLUSIONS
Treatment of selected intracranial aneurysms via an endovascular approach has merit and could supplant more invasive, risky, and costly surgical procedures in some cases.
Department of Diagnostic Radiology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill 60612.
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Geremia
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Haklin
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Brennecke
D000818:Animals; D001921:Brain / Q000098:blood supply; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D002533:Cerebral Angiography; D003035:Cobalt; D004195:Disease Models, Animal; D004285:Dogs; D004547:Elastic Tissue / Q000473:pathology; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D015607:Stents
D003035:Cobalt