Possible involvement of the EP2 receptor subtype in PGE2-induced enhancement of the heat response of nociceptors.
Prostaglandin E2 augments bradykinin- and heat-induced discharges of polymodal receptors as studied in vitro preparations. Our previous study revealed the involvement of the EP3 receptor subtype in the PGE2 induced enhancement of the BK response [Brain Res. 632 (1993) 321-324]. The agonist for EP2 (butaprost; 10(-8) M) significantly augmented heat responses, but did not augment the BK responses at concentrations from 10(-8) to 10(-5) M; however, the agonist for EP3 (M&B28767) or EP1 (17-phenyl-trinor-PGE2) at 10(-7) M did not affect the heat responses. These findings indicate the involvement of the EP2 receptor subtype in the augmenting effect of PGE2 on heat responses.
Kumazawa
T
T
Department of Neural Regulation, Nagoya University, Japan.
Mizumura
K
K
Koda
H
H
D000527:Alprostadil / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004285:Dogs; D006358:Hot Temperature; D066298:In Vitro Techniques; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D018078:Receptors, Prostaglandin E / Q000819:agonists / Q000502:physiology*; D013737:Testis / Q000294:innervation*; D013997:Time Factors
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D018078:Receptors, Prostaglandin E; D000527:Alprostadil; C048491:butaprost; D001920:Bradykinin