8-Amino-2'-deoxyadenosine: 2'-deoxythymidine base pairing: identification of novel reverse Hoogsteen mode in solution.
A novel reversed Hoogsteen mode is observed for the base-pairing of 8-amino-2'-deoxyadenosine with 2'-deoxythymidine in low dielectric solvent. The results may have important significance for designing novel DNA duplexes and triplexes incorporating 8-amino-dA.
Kumar
R K
RK
Organic Chemistry Division, National Chemical Laboratory, Pune, India.
Gunjal
A D
AD
Ganesh
K N
KN
D001482:Base Composition; D003839:Deoxyadenosines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012996:Solutions; D013936:Thymidine / Q000737:chemistry*
D003839:Deoxyadenosines; D012996:Solutions; C090166:8-amino-2'-deoxyadenosine; D013936:Thymidine