Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5.
The genetic map location of the recently discovered imprinted gene U2afbpL has been verified and refined in several mouse crosses. RI strain analysis had previously shown that the gene is located on mouse chromosome 11. This assignment has been verified using interspecific backcrosses. Moreover, the location of the gene relative to a fixed order of markers in the proximal region of mouse chromosome 11 has been established. The location of the gene on mouse chromosome 11 corresponds to a homologous linkage group that is conserved on human chromosome 5q. The location of the human homologue has been determined using both somatic cell hybrid genetic analysis and fluorescence in situ hybridization. These analyses have mapped the human locus U2AFBPL to human chromosome 5q23-->q31.
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffallo, NY 14263.
I
I
Kalcheva
C
C
Plass
S
S
Sait
R
R
Eddy
T
T
Shows
D
D
Watkins-Chow
S
S
Camper
H
H
Shibata
T
T
Ueda
N
N
Takagi
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D017124:Conserved Sequence; D003433:Crosses, Genetic; D005819:Genetic Markers; D018392:Genomic Imprinting; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics; D009115:Muridae / Q000235:genetics*; D009687:Nuclear Proteins; D011995:Recombination, Genetic; D015183:Restriction Mapping; D012261:Ribonucleoproteins / Q000378:metabolism; D013045:Species Specificity; D000072668:Splicing Factor U2AF
D005819:Genetic Markers; D009687:Nuclear Proteins; D012261:Ribonucleoproteins; D000072668:Splicing Factor U2AF; C000607494:U2AF2 protein, human; C000607495:Zrsr1 protein, mouse