Toxicologic evaluation of acute and subacute oral administration of Cucurbita maxima seed extracts to rats and swine.
The extract prepared from dried seeds of Cucurbita maxima was administered to rats and pigs. Following a single dose or 4 weeks of daily oral administration, the extract produced no changes in serum glucose, urea, creatinine, total protein, uric acid, GOT, GPT, LDH or blood counts. Urine analysis (urea, uric acid, creatinine, total protein, Na and K), as well as histopathological investigation, showed no abnormalities. These results taken as a whole indicate that the seeds of C. maxima as used in Brazilian folk medicine are not toxic for rats and swine.
de Queiroz-Neto
A
A
Departamento de Morfologia e Fisiologia Animal, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, São, Paulo, Brazil.
Mataqueiro
M I
MI
Santana
A E
AE
Alessi
A C
AC
D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis; D001938:Brazil; D003404:Creatinine / Q000097:blood / Q000652:urine; D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects; D013552:Swine; D014508:Urea / Q000097:blood / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000652:urine
D001786:Blood Glucose; D001798:Blood Proteins; D004573:Electrolytes; D010936:Plant Extracts; D014527:Uric Acid; D014508:Urea; D003404:Creatinine