Effects of beta-blocking agents on the release of various enzymes in muscular tissues.
We examined the kinetics study of serum enzyme after the administration of beta-blocking agents or alpha-stimulator in the experimental rats. Following the administration of beta-blocking agents, propranolol and pindolol, the serum levels of adenylate kinase, aldolase, lactate dehydrogenase and aspartate aminotransferase as well as that of creatine kinase increased in rats. The same was observed following the administration of noradrenaline (an alpha-stimulator). Isoenzyme pattern indicated that most of these enzymes were considered to be released from muscular tissues. There were also changes in serum calcium, inorganic phosphorus and magnesium, concurrently with the release of the enzymes into the serum.
Itoh
H
H
Department of Clinical Chemistry, Kitasato University School of Hygienic Sciences, Kanagawa, Japan.
Jingu
Y
Y
Numakami
K
K
Saruta
T
T
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood*; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344
D000319:Adrenergic beta-Antagonists; D004573:Electrolytes; D004798:Enzymes; D011433:Propranolol; D010869:Pindolol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase