Investigation of the anti-inflammatory effects of Paederia foetida.
A detailed investigation on the anti-inflammatory activity of the butanol fraction of a methanol extract (BMEL) of the defatted leaves of Paederia foetida was undertaken to find the pharmacological basis for the ethnomedical use of the plant. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. It decreased liver aspartate transaminase activity without affecting serum aspartate transaminase activity. It did not, however, affect adrenal weight and ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. BMEL antagonised hyposaline-induced haemolysis of human red blood cells and an elevation of rat serum acid phosphatase activity, indicating the presence of a membrane stabilising activity. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. The results indicate that there is some rationale behind the ethnomedical use of the plant for treating inflammatory disorders.
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Institute of Post Graduate Teaching and Research, Gujarat Ayurved University, India.
Ravishankar
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Bhavsar
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GC
D020001:1-Butanol; D000135:Acid Phosphatase / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D000440:Butanols / Q000737:chemistry; D005591:Chemical Fractionation; D004195:Disease Models, Animal; D004910:Erythrocyte Membrane / Q000187:drug effects; D005260:Female; D006099:Granuloma / Q000517:prevention & control*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008519:Medicine, Traditional; D000432:Methanol / Q000737:chemistry; D009929:Organ Size / Q000187:drug effects; D009961:Orosomucoid / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013154:Spleen / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001798:Blood Proteins; D000440:Butanols; D009961:Orosomucoid; D010936:Plant Extracts; D020001:1-Butanol; D001219:Aspartate Aminotransferases; D000135:Acid Phosphatase; D001205:Ascorbic Acid; D000432:Methanol