Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.
We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not "in line" in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.
Aiba
A
A
Howard Hughes Medical Institute, Center for Learning and Memory, Cambridge, Massachusetts.
Chen
C
C
Herrup
K
K
Rosenmund
C
C
Stevens
C F
CF
Tonegawa
S
S
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000737:chemistry; D004558:Electric Stimulation; D005260:Female; D005796:Genes; D006624:Hippocampus / Q000473:pathology / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009473:Neuronal Plasticity; D017470:Receptors, Glutamate / Q000502:physiology*; D015183:Restriction Mapping; D009435:Synaptic Transmission
D017931:DNA Primers; D017470:Receptors, Glutamate