Disposition of magnolol after intravenous bolus and infusion in rabbits.
A simple and sensitive high-performance liquid chromatographic method was developed for the determination and identification of magnolol to study its pharmacokinetics in rabbits after a 5 mg/kg i.v. bolus and 76 micrograms/kg/min i.v. infusion. Plasma concentration time profiles were suited to a two-compartment open model. The elimination half-lives of magnolol were 14.56 and 15.71 min, and the total body clearances were 75.86 and 72.72 ml/min/kg for i.v. bolus and i.v. infusion, respectively. There were no significant differences in elimination half-life and total body clearance between i.v. bolus and i.v. infusion, which suggests that magnolol pharmacokinetics are linear.
National Research Institute of Chinese Medicine, Taipei, Taiwan.
T H
TH
Tsai
C J
CJ
Chou
C F
CF
Chen
D000818:Animals; D001713:Biphenyl Compounds / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D017705:Lignans; D008297:Male; D011817:Rabbits; D012015:Reference Standards; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D000498:Allyl Compounds; D010636:Phenols
D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols