[Studies on magnetic responsiveness and renal embolization with magnetic microspheres in dogs].
The responsiveness and transcatheter embolization with magnetic gelatin microspheres (MG-ms) in dog kidney were reported. In experiments with magnet using a constant flow apparatus such as roller pump, the percent retention was determined by counting the carrier retained by the magnetic field and divided by the total starting counts. Factors influencing the percent retention of MG-ms include: velocity of medium flow, magnetic field intensity, alpha-Fe2O3 content in the MG-ms, viscosity of the medium and so on. Transcatheter embolization with MG-ms (10-30 microns) was performed under external magnet control in dog kidney. The result of angiogram and histological section showed that the MG-ms were in the arteries, arterioles, and glomerular capillaries with no adverse reactions. The embolized effect with magnet field was more prominent than the group without magnet field. These results show that the MG-ms is a promising embolic agent for treatment of renal cancer under external magnet control.
School of Pharmaceutical Sciences, Beijing Medical University.
C B
CB
Wu
S L
SL
Wei
W
W
Lu
Y L
YL
Zhao
W W
WW
Gao
D000818:Animals; D004285:Dogs; D004621:Embolization, Therapeutic; D005780:Gelatin; D008280:Magnetics; D008863:Microspheres; D012077:Renal Artery
D005780:Gelatin