[Potentiation of digoxin by itraconazole].
The case is reported of a 71-year-old woman with clinical signs of digoxin intoxication, presumably developing as a result of the simultaneous use of digoxin for cardiac abnormalities and itraconazole for infection with Candida albicans. Five similar experiences have previously been reported in the literature. Itraconazole may induce a decreased elimination of digoxin, but the mechanism of interaction is still unknown. Comedication and renal function may perhaps contribute to the degree of interaction. When itraconazole is needed in a patient also using digoxin the blood level of the latter drug should be monitored; the daily dose of digoxin may have to be decreased to only one-quarter of the original. Nausea and anorexia may be mistaken for side effects of itraconazole and be overlooked as early signs of digoxin intoxication.
Stichting Landelijke Registratie Evaluatie Bijwerkingen LAREB, Tilburg.
R H
RH
Meyboom
K
K
de Jonge
H
H
Veentjer
J A
JA
Dekens-Konter
G H
GH
de Koning
D000368:Aged; D002179:Candidiasis, Cutaneous / Q000188:drug therapy*; D004077:Digoxin / Q000506:poisoning* / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology* / Q000627:therapeutic use
D017964:Itraconazole; D004077:Digoxin
Potentiëring van digoxine door itraconazol.