[Possible markers of the progression and ulcerogenesis of stomach cancer].
The stomachs from 40 patients operated on for gastric cancer and chronic ulcer were studied immunohistochemically using antibodies to CEA, galactosyl transferase, pepsinogens A and C, gastrin, alpha 1-antitrypsin. CEA and galactosyl transferase of the cancer parenchyma are shown to mark tumor progression. The ratio of alpha 1-antitrypsin to pepsinogens in gastric epithelium and cancer cells probably plays a role in ulcerogenesis of normal mucosa and tumor tissue. Gastrin in carcinoma tissue is both an ulcerogenesis factor and a marker of tumor progression, an unfavourable prognosis of gastric cancer.
Serov
V V
VV
Iushkov
P V
PV
Ivanov
P K
PK
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism*; D002293:Adenocarcinoma, Scirrhous / Q000150:complications / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D018276:Carcinoma, Medullary / Q000150:complications / Q000378:metabolism*; D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000378:metabolism*; D002908:Chronic Disease; D018450:Disease Progression; D005700:Galactosyltransferases / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D010435:Pepsinogens / Q000378:metabolism; D013274:Stomach Neoplasms / Q000150:complications / Q000378:metabolism*; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005755:Gastrins; D010435:Pepsinogens; D000515:alpha 1-Antitrypsin; D005700:Galactosyltransferases
Vozmozhnye markery progressii i ul'tserogeneza raka zheludka.