Asbestos use and carcinogenicity in Germany and a comparison with animal studies.
The centralized structure of economic affairs in the former German Democratic Republic (East Germany) and the isolation from the free market led to the situation that imported asbestos was almost exclusively chrysotile. More than 90% came from the Kiembay mining area in the Ural Mountains, and about 7% was long-fibre chrysotile from Canada. Sturm and co-workers detected 1082 mesothelioma cases from 1960 to 1990 in the counties of Magdeburg and Halle. In 843 of these cases an exposure to asbestos was evident. Seventy-two cases were exposed to chrysotile only. Suspected exposure to amphiboles imported before World War II or to fibre contained in talc could not be substantiated. Up to now, there have been no analyses of lung fibre burdens from such cases. Reviewing the carcinogenicity studies in rats performed by inhalation or intra-cavitary injection of chrysotile, amosite and crocidolite fibres, the results give no clear indication of a lower carcinogenic potency per chrysotile fibre than per amphibole fibre if equal fibre numbers and fibre sizes are applied, although the chrysotile content of the lungs is relatively low. Also the mesothelioma rates after inhalation exposure to extremely high concentrations of the different asbestos fibre types are similar for chrysotile and the amphiboles and in the region of 5%. Compared with the asbestos-related cancer rates in chrysotile textile workers, rats have to be exposed to a more than 100-fold higher fibre concentration than humans to induce the same lung tumour incidence.
Pott
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D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D017636:Asbestos, Amphibole / Q000009:adverse effects; D017638:Asbestos, Crocidolite / Q000009:adverse effects; D017632:Asbestos, Serpentine / Q000009:adverse effects; D016022:Case-Control Studies; D005859:Germany, East; D005860:Germany, West; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008654:Mesothelioma / Q000209:etiology*; D015337:Multicenter Studies as Topic; D016273:Occupational Exposure; D010997:Pleural Neoplasms / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine; D017638:Asbestos, Crocidolite; D001194:Asbestos