Spasticity: a review.
This symposium is concerned with the treatment of spasticity and, in particular, with results from studies of tizanidine as a treatment for patients with MS and spinal cord injury. In this article, the definitions and pathophysiologies of spasticity are reviewed, and the issue of when and if to treat spasticity is evaluated. The merits of newer pharmacologic and invasive therapies are discussed relative to reduction of patient discomfort and the possibility of restored function.
Department of Neurology, University of California, Irvine 92717-4275.
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D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology; D012026:Reflex, Stretch / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology
D009125:Muscle Relaxants, Central; D018377:Neurotransmitter Agents; C023754:tizanidine; D003000:Clonidine