The interaction of ANF and C-terminal fragment ANF (24-28)OH with agonist and antagonist of the beta-adrenergic receptor in the cardiovascular system in rats.
1. The interaction of ANF and ANF(24-28)OH with the agonist, Isoprenaline (ISO), and the antagonist, Propranolol (PRO), of beta-adrenergic receptor in the cardiovascular system in rat was investigated. 2. The studies showed that ANF and C-terminal fragment of ANF, ANF(24-28)OH, interfered with beta-adrenergic receptor. 3. This does not exclude the action of this pentapeptide on the other receptors.
Department of Pharmacology, Medical Academy, Bialystok, Poland.
B
B
Mikoluc
R J
RJ
Wisniewska
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor; D011433:Propranolol; D007545:Isoproterenol