[Treatment of prostatic carcinoma with UFT and leucovorin--basic study using SRCA].
Combination effect of UFT and leucovorin against the rat prostatic carcinoma (R-3327) was evaluated by the subrenal capsular assay (SRCA) using nude mice. Anticancer effect of UFT was augmented by co-administration of both low and high dose leucovorin. These results suggest a clinical usefulness of UFT administration with leucovorin for the patients with hormonally refractory advanced prostatic carcinoma.
Dept. of Urology, University of Tsukuba.
K
K
Uchida
T
T
Hayashi
T
T
Shiga
K
K
Hattori
Y
Y
Nishijima
S
S
Kasaya
T
T
Shimazui
H
H
Akaza
K
K
Koiso
R
R
Nemoto
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000473:pathology*; D013370:Subrenal Capsule Assay; D005641:Tegafur / Q000008:administration & dosage / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014498:Uracil / Q000008:administration & dosage / Q000494:pharmacology
D005641:Tegafur; D014498:Uracil; D002955:Leucovorin