201Tl myocardial perfusion SPET: adenosine alone or combined with dynamic exercise.
201Tl myocardial perfusion single photon emission tomography (SPET) with pharmacological coronary vasodilatation using adenosine is now often used in the investigation of a patient with ischaemic heart disease (IHD). In this study, we present data from two groups of patients. Group A (n = 40) experienced 201Tl SPET with adenosine only as the pharmacological stress test, using an infusion rate of 140 micrograms kg-1 min-1. Group B patients (n = 50) had the same test combined with low-level dynamic exercise. The side effects were noted for both groups and 201Tl SPET studies were acquired for stress and redistribution images. There was a lesser degree of non-cardiac side effects in patients of group B. There was a significant difference in the haemodynamic parameters between the two groups. There was no significant difference in overall sensitivity (87% versus 90%) and specificity (84% versus 88%) in the detection of IHD between the two groups. In conclusion, addition of low-level dynamic exercise with adenosine is to be preferred to adenosine infusion alone, as this protocol is better tolerated and may enhance the detection of right coronary artery disease (sensitivity = 82% versus 90%, n.s.).
Institute of Nuclear Medicine, University College London Medical School, UK.
S
S
Mahmood
N K
NK
Gupta
M
M
Gunning
J B
JB
Bomanji
P H
PH
Jarritt
P J
PJ
Ell
D000241:Adenosine / Q000009:adverse effects; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D017023:Coronary Angiography; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon
D011868:Radioisotopes; D000241:Adenosine; D013691:Tellurium