Epigenetic nature of radiation carcinogenesis at low doses.
The present paradigm of radiation-induced carcinogenesis has been based on somatic mutation theory initiating a mutation in somatic cells derived from DNA damage by ionizing radiation. A non-threshold linear model has been assumed from high doses to low doses. As an alternative to this, we are proposing a new model that epigenetic changes induced by low dose irradiation may be a first step of carcinogenesis. Our preliminary data suggesting the epigenetic nature and reports on various stress response to ionizing radiation are presented.
Health Research Foundation, Kyoto, Japan.
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Sugahara
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Watanabe
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D006224:Cricetinae; D016207:Cytokines / Q000528:radiation effects; D004249:DNA Damage / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian / Q000166:cytology / Q000528:radiation effects; D008647:Mesocricetus; D009154:Mutation / Q000528:radiation effects; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000473:pathology*; D011829:Radiation Dosage
D016207:Cytokines