[Indosol--a nonsteroidal anti-inflammatory drug with therapeutic efficacy].
For the topical employing of nonsteroidal antiinflammatory drugs, some technological problems are to be solved. These were accomplished by the authors by preparing Indosol [indomethacin-TRIS (tromethamine) salt]. pH and osmotic pressure of Indosol eye-drops are similar to that of the tear fluid. The Indosol eye-drops have a great therapeutic efficacy. Indosol eye-drops do not alter tear film break up time (BUT) and do not inhibit reepithelization of the cornea. Indosol eye-drops proved to be useful in the treatment of the anterior segment and the uvea. The most important use is the pre- and post-treatment in intraocular surgery. Indosol eye-drops contribute to the safety of lens-extraction and lens implantation. The great bioavailability was also shown by the high indomethacin level of the aqueous humor after instillation Indosol eye-drops. It does not cause any deleterious side-effects even in long term treatments.
Kahánné
L I
LI
SOTE II. sz. Szemklinika, Budapest.
Bögi
J
J
Farkas
A
A
Tüdös
F H
FH
Imre
G
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001682:Biological Availability; D003315:Cornea / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007910:Lenses, Intraocular; D009883:Ophthalmic Solutions; D013666:Tears; D014602:Uvea
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D007213:Indomethacin
Az Indosol--nagy terápiás hatású nemszteroid gyulladásgátló--ismertetése.