[Autologous bone marrow transplantation in the treatment of children with neuroblastoma; 30 patients in 10 years].
OBJECTIVE
To evaluate the role of high dose chemotherapy and autologous bone marrow transplantation (ABMT) in children with metastasized neuroblastoma (stage IV) in partial or complete remission.


METHODS
Retrospective analysis.


METHODS
The former Emma Child Hospital and the Academic Medical Center, Amsterdam.


METHODS
In the period January 1980 to May 1991, ABMT was used in 30 children (mean age 3 years) with a neuroblastoma stage IV treated with chemotherapy. Occurrence of fever, infections, haemorrhagic diathesis, mucositis, ileus and the duration of hospital stay were measured as indications of illness. The mean weight loss and the duration of aplasia were also measured.


RESULTS
Eight of 30 patients stayed alive until June 1993. Three patients died within 1 month after start of treatment. The median survival of the other 19 patients was 15 months. The mean weight loss was 7.6% and the period of aplasia had a mean duration of 18-20 days. Two-year disease free survival was 26.6% with a median follow-up of 118.5 months (29-150).
Emma Kinderziekenhuis/het Kinder-AMC, afd. Kinderoncologie, Amsterdam.
J
J
de Kraker
F
F
Boon
E F
EF
van Leeuwen
P A
PA
Voûte
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001835:Body Weight; D016026:Bone Marrow Transplantation / Q000379:methods*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000401:mortality / Q000628:therapy*; D010198:Pancytopenia / Q000175:diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents
Autologe beenmergtransplantatie bij de behandeling van kinderen met neuroblastoom; 30 patiënten in 10 jaar.