[Hypothermic effects on uveal blood flow and postoperative inflammation in vitrectomy].
Hypothermic effects on uveal blood flow and postoperative inflammation were evaluated in experimental vitrectomy on albino rabbits. Solutions used for intraocular perfusion were maintained at 9 degrees C and 22 degrees C. Following the vitrectomy, the rabbits' intraocular spaces were irrigated for 60 minutes. The temperature at various sites and the uveal blood flow were measured before and during the procedure. Aqueous protein concentrations were checked on postoperative days 1, 7, and 14. Another solution maintained at 37 degrees C was used as a control. There was a larger decrease in temperature at the retina than there was at the choroid and the ciliary body. Blood flow at the ciliary body decreased to 76.0% and 77.0% at the choroid after 60 minutes of irrigation at 9 degrees C. The decrease at 22 degrees C were 91.0% and 88.3%, respectively. Aqueous protein concentrations at both 9 degrees C and 22 degrees C were significantly lower than at 37 degrees C on the first postoperative day in the eyes irrigated for 60 minutes. In the eyes irrigated for 30 minutes, however, no significant differences were seen. Hypothermia during a prolonged vitrectomy operation seems to decrease inflammation in early postoperative stages.
Department of Ophthalmology, Nagoya City University Medical School, Japan.
K
K
Tamai
A
A
Majima
C
C
Yan
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism; D007036:Hypothermia, Induced; D011817:Rabbits; D012039:Regional Blood Flow; D014602:Uvea / Q000098:blood supply*; D014605:Uveitis / Q000209:etiology / Q000517:prevention & control*; D014821:Vitrectomy / Q000009:adverse effects*
D005136:Eye Proteins