[An animal model for testing hypoglycemic and hypolipidemic drugs].
A new animal model of hyperglycemia and hyperlipidemia was established by treating normal Kunming mice with alloxan (iv). After different time intervals, the levels of blood glucose (BG) and serum triglyceride (TG) were determined. Forty-eight h after alloxan administration, the BG increased significantly, and the level of serum triglyceride reached maximum. The levels of blood glucose, serum triglyceride, cholesterol (CHOL) and free fatty acid (FFA) for vehicle treated mice were about 3.1, 4.0, 1.1, and 1.7 times those of normal Kunming mice, respectively. To evaluate the new animal model, four drugs were used. Two of them were antihyperglycemic drugs, metformin and a Recipe of Chinese Herbs (RCH). The other two were antihyperlipidemic agents, clofibrate and fenofibrate. All drugs showed positive effects on this kind of alloxan-diabetic Kunming mice. It can be concluded that this kind of alloxan-treated Kunming mice is useful for testing hypoglycemic and hypolipidemic drugs.
Liu
J
J
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Shen
Z F
ZF
Liu
H F
HF
Ye
F
F
Xie
M Z
MZ
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000188:drug therapy; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D051379:Mice
D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D008687:Metformin