Detection of hydroxyl free radicals in the reperfused primate heart.
Early reperfusion of an ischemic region can result in significant salvage of the area at risk. We show the presence of hydroxyl free radicals at the time of post ischemia reperfusion using electron paramagnetic resonance (EPR) spectroscopy in a macaque model. These free radicals may be formed as a result of reperfusion or may be an un-involved bystander. It is possible that they may be involved in reperfusion injury.
Premaratne
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Department of Surgery, John A. Burns School of Medicine, University of Hawaii at Manoa, Queen's Medical Center, Honolulu 96813.
Suehiro
A
A
Suehiro
G T
GT
Arakaki
H Y
HY
McNamara
J J
JJ
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D004562:Electrocardiography; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D017665:Hydroxyl Radical / Q000032:analysis*; D008253:Macaca mulatta; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D018754:Ventricular Dysfunction / Q000209:etiology
D017665:Hydroxyl Radical