Effects of fatty acids on proliferation and activation of human synovial compartment lymphocytes.
The object of this study was to determine the effects of eicosanoid precursor fatty acids on activation and proliferation of T lymphocytes from synovial fluid and synovial tissue of rheumatoid arthritis patients. Proliferation was determined by direct cell counts; phenotypic characterization of surfaces molecules was by cytofluorometric analysis. Dihomogammalinolenic acid, arachidonic acid, and eicosapentaenoic acid suppressed proliferation of interleukin-2-dependent lymphocytes by as much as 80%; cell viability was not altered by fatty acids. Administration of particular fatty acids may prove to be a useful therapeutic intervention in rheumatoid arthritis patients because of their ability to suppress activation and proliferation of synovial compartment T lymphocytes.
Department of Medicine, University of Pennsylvania, Wistar Institute of Anatomy & Biology, Philadelphia.
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DM
DeMarco
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D
Santoli
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Zurier
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004537:Eicosanoic Acids / Q000494:pharmacology*; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D013582:Synovial Fluid / Q000166:cytology*; D013583:Synovial Membrane / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000473:pathology
D004537:Eicosanoic Acids; D007376:Interleukin-2