In vitro toxicity of trichothecenes on human haematopoietic progenitors.
The culture of human haematopoietic progenitors, Colony-Forming-Unit Granulocyte and Macrophage (CFU-GM), has been performed in the presence of four trichothecenes, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), and deoxynivalenol (DON). Our results showed that trichothecenes were cytotoxic for human haematopoietic progenitors. This work and the analysis of results described in the literature allowed us to propose that the haematologic lesions observed during human intoxication could be due to a destruction of haematopoietic progenitors such as granulocytic and macrophage colony-forming cells.
Laboratoire de Microbiologie et Biochimie, Ecole Supérieure de Microbiologie et Sécurite Alimentaire, Isamor, Technopole Brest-Iroise, Plouzane, France.
D
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Parent-Massin
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Fuselier
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Thouvenot
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D013605:T-2 Toxin / Q000031:analogs & derivatives / Q000494:pharmacology; D014255:Trichothecenes / Q000494:pharmacology* / Q000633:toxicity
D014255:Trichothecenes; D013605:T-2 Toxin; C007262:deoxynivalenol; C012351:HT-2 toxin; C001809:diacetoxyscirpenol