A glucan having reticuloendothelial system-potentiating and anti-complementary activities from the tuber of Pinellia ternata.
A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata BREIT. It was homogenous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 10(4). It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of alpha-1,4-linked D-glucopyranose residues with partially alpha-1,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.
Kyoritsu College of Pharmacy, Tokyo, Japan.
M
M
Tomoda
R
R
Gonda
N
N
Ohara
N
N
Shimizu
C
C
Shishido
Y
Y
Fujiki
D000107:Acetylation; D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D015941:Complement Hemolytic Activity Assay; D003165:Complement System Proteins / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D005936:Glucans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008745:Methylation; D051379:Mice; D008970:Molecular Weight; D012157:Mononuclear Phagocyte System / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D000516:alpha-Amylases / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005936:Glucans; D003165:Complement System Proteins; D000516:alpha-Amylases; D005947:Glucose