Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta).
The macaque infectious dose (MID) of a single-cell clone of simian immunodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one macaques were inoculated with 10-fold dilutions of the virus stock (three or four animals per dose). The virologic and clinical status of these animals was monitored for 26 weeks. The 25% MID (MID25) occurred at a 10(5)-fold dilution of the viral stock.
Benveniste
R E
RE
Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21702-1201.
Roodman
S T
ST
Hill
R W
RW
Knott
W B
WB
Ribas
J L
JL
Lewis
M G
MG
Eddy
G A
GA
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D017931:DNA Primers; D015151:Immunoblotting; D008253:Macaca mulatta / Q000821:virology*; D008254:Macaca nemestrina; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology; D015302:Simian Immunodeficiency Virus / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*
D000914:Antibodies, Viral; D017931:DNA Primers