Interstitial nephritis associated with 5-aminosalicylic acid.
A patient with severe Crohn's disease was treated with 5-aminosalicylic acid (5-ASA). Following initiation of treatment, serum creatinine increased slowly from 105 to 530 mumol/l (creatinine clearance 16 ml/min). The diagnosis of an interstitial nephritis was made based on normal urinary findings and the renal biopsy histology of interstitial mononuclear infiltrates and normal glomeruli, 5-ASA was discontinued and serum creatinine decreased to 245 mumol/l (creatinine clearance 40 ml/min) during the following 3 months. Partial reversibility of renal failure following discontinuation of 5-ASA and the absence of other drugs possibly causing interstitial nephritis suggest a causal relationship between 5-ASA and interstitial nephritis.
Witte
T
T
Division of Nephrology, Medical School Hannover, Germany.
Olbricht
C J
CJ
Koch
K M
KM
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D003424:Crohn Disease / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008297:Male; D019804:Mesalamine; D009395:Nephritis, Interstitial / Q000097:blood / Q000139:chemically induced*
D000636:Aminosalicylic Acids; D019804:Mesalamine; D003404:Creatinine