[Immunologic aspects of disorders of neuromuscular transmission. 2. Experimental autoimmune myasthenia gravis and the Lambert-Eaton myasthenic syndrome].
This paper describes two condition caused by disfunction of neuromuscular transport: experimental autoimmune myasthenia gravis (EAMG) and Lambert-Eaton myasthenic syndrome (LEMS). EAMG can be caused by immunization with acetylcholine receptors (AChR). As in myasthenia gravis, anti-AChR antibodies reduce the number of these receptors, which impedes normal neuromuscular transmission. LEMS patients have normal AChR function: however there is a disfunction of acetylcholine release from the presynaptic terminals. This is due to the formation of antibodies against the voltage gated calcium channels on the presynaptic nerve terminals.
Andreis
I
I
Zavod za fiziologiju Medicinskog fakulteta Sveucilista u Zagrebu.
Lovnićki
T J
TJ
Beara
N
N
Taradi
M
M
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000276:immunology* / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000276:immunology* / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000276:immunology; D009435:Synaptic Transmission
D011950:Receptors, Cholinergic
Imunoloski aspekti poremećaja neuromuskularnog prijenosa. 2. Eksperimentalna autoimuna miastenja gravis i Lambert-Eatonov miastenicni sindrom.