Dysregulation of airway cytokine expression in chronic obstructive pulmonary disease and asthma.
Cigarette smoking is the major factor responsible for chronic obstructive pulmonary disease (COPD). COPD occurs in a minority of smokers, but the host factors that modify risk of disease have not been clearly elucidated. There is significant clinical and histopathologic overlap between COPD and asthma, including the accumulation and activation of airway inflammatory cells. These two disorders are compared and contrasted. Abnormal airway inflammatory cytokine expression in these disorders is discussed.
Hasday
J D
JD
Department of Medicine, University of Maryland School of Medicine, Baltimore.
McCrea
K A
KA
Meltzer
S S
SS
Bleeker
E R
ER
D001249:Asthma / Q000209:etiology / Q000503:physiopathology*; D001980:Bronchi / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016207:Cytokines / Q000032:analysis / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000209:etiology / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology
D016207:Cytokines