Localization of experimental brain tumors in MRI by gadolinium porphyrin.
The contrast between edema and F98 glioma in rat brain was distinctly enhanced in T2-weighted MRI (TE 130 ms, TR 3 s) by intraperitoneal injection of the synthetic gadolinium-porphyrin complex, GdTPPS. The T1 relaxation time of the gliomas was selectively shortened by about 50% from 1339 +/- 109 ms to 628 +/- 106 ms, and the T2 relaxation time was shortened by about 35% from 86 +/- 6 ms to 57 +/- 5 ms. The relaxation times of normal tissues under investigation (cortex, corpus callosum, temporal muscle, ventricles) were unaltered. Therefore, GdTPPS-application causes F98 gliomas to appear hyperintense in T1-weighted MRI and hypointense in T2-weighted MRI.
Department of Experimental Neurology, May-Planck-Institute for Neurological Research, Cologne, Federal Republic of Germany.
K
K
Bockhorst
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T
Els
K
K
Kohno
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M
Hoehn-Berlage
D000818:Animals; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D002460:Cell Line; D003287:Contrast Media; D005682:Gadolinium; D005910:Glioma / Q000473:pathology*; D007274:Injections, Intraperitoneal; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009368:Neoplasm Transplantation; D011166:Porphyrins; D051381:Rats
D003287:Contrast Media; D011166:Porphyrins; C016136:tetraphenylporphine sulfonate; D005682:Gadolinium