Residual sedating effects of ethanol.
To test for dose and duration effects of residual sedation, ethanol (0.0, 0.5, and 0.9 g/kg) was administered (at 0830, 1030, and 0730 hr, respectively) to 10 healthy, normal-sleeping men, aged 21-35 years. The Multiple Sleep Latency Test was conducted at 0930, 1130, 1330, 1530, 1730, 1930, and 2130 hr, and a divided attention performance assessment was done at 1400, 1600, 1800, and 2000 hr. Breath ethanol concentration for both doses was 0.04% at 1130 hr, 0.01% at 1330 hr, and 0 at 1530 hr. A significant reduction in sleep latency was observed from 0930 to 1530 hr, but not thereafter. Divided attention performance overall was significantly impaired on the 1400-hr test only. These data again showed residual sedation and suggest residual sedation is time limited and not affected in duration or intensity by dose.
Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202.
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Roehrs
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Claiborue
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Knox
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Roth
D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects*; D001944:Breath Tests; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D009949:Orientation / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*
D000431:Ethanol