Deprenyl enhances neurite outgrowth in cultured rat spinal ventral horn neurons.
Deprenyl, a selective monoamine oxidase B inhibitor, is effective in Parkinson's disease, and can slow the cognitive deterioration in Alzheimer's disease. However, it is not known whether this agent has a trophic effect on spinal motor neurons. We have studied neurotrophic effects of deprenyl on spinal motor neurons, using explanted ventral spinal cord culture from 13-day-old rat embryos. Deprenyl-treated cultures significantly enhanced neurite outgrowth with cultures of ventral spinal cord. Our data suggest that deprenyl is one of the candidate for neurotrophic factors on spinal motor neurons in vitro. A possible role for deprenyl in amyotrophic lateral sclerosis remains to be defined.
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
Y
Y
Iwasaki
K
K
Ikeda
T
T
Shiojima
T
T
Kobayashi
N
N
Tagaya
M
M
Kinoshita
D000818:Animals; D000870:Anterior Horn Cells / Q000166:cytology / Q000187:drug effects*; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D009994:Osmolar Concentration; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D051381:Rats; D012642:Selegiline / Q000494:pharmacology*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
D012642:Selegiline; D010751:Phosphopyruvate Hydratase