Application of hydroxyapatite-sol as drug carrier.
The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 x 15 x 10 mm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.
Kano
S
S
Materials Engineering Department, Mechanical Engineering Laboratory, Ibaraki, Japan.
Yamazaki
A
A
Otsuka
R
R
Ohgaki
M
M
Akao
M
M
Aoki
H
H
D000327:Adsorption; D002126:Calcium Hydroxide / Q000737:chemistry; D003102:Colloids / Q000138:chemical synthesis / Q000737:chemistry*; D003461:Crystallography; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009062:Mouth Neoplasms / Q000188:drug therapy; D010316:Particle Size; D010756:Phosphoric Acids / Q000737:chemistry; D014407:Tumor Cells, Cultured; D014465:Ultrasonics; D014961:X-Ray Diffraction
D003102:Colloids; D004337:Drug Carriers; D008768:Methylmethacrylates; D010756:Phosphoric Acids; D020366:Methylmethacrylate; D004317:Doxorubicin; D017886:Durapatite; D002126:Calcium Hydroxide