Protective effect of KW-3635, a specific thromboxane A2-receptor antagonist, on experimental glomerulonephritis in mice.
We studied the effect of KW-3635, a selective thromboxane A2 (TXA2)-receptor antagonist, on experimental glomerulonephritis. The glomerulonephritis was induced in mice by the administration of rabbit anti-mouse glomerular basement membrane (GBM) antibody. It was characterized as proteinuria, changes of serum biochemical parameters and glomerular histopathological abnormalities. The administration of KW-3635 (30 mg/kg/day, p.o.) significantly ameliorated the proteinuria, elevation of serum urea nitrogen and the thickening of GBM. These data suggest that TXA2 may play an important pathogenic role in the development and progression of glomerulonephritis.
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
M
M
Kawakage
K
K
Sato
A
A
Karasawa
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000633:toxicity; D001485:Basement Membrane / Q000276:immunology; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001584:Benzoxepins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D011507:Proteinuria / Q000188:drug therapy*; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D000911:Antibodies, Monoclonal; D001562:Benzimidazoles; D001584:Benzoxepins; D013928:Thromboxane A2; C065729:KW 3635