Nuclear deoxyribonucleic acid content in inverted papilloma of the urothelium.
We analyzed formalin-fixed and paraffin-embedded materials from urothelial inverted papillomas using flow-cytometric DNA analysis to investigate the intrinsic nature in terms of the malignant potentials. DNA indices of the inverted papillomas ranged between 1.00 and 1.26 with a mean value of 1.12. The percentage of S phase of a tumor DNA histogram showed greater values in every case compared with a normal DNA histogram. This tumor form could be thus regarded as a diploid neoplastic disease with a relatively higher proliferative activity, although 1 case showed an aneuploid pattern (DNA index = 1.26), in which bladder carcinoma developed subsequently.
Kunimi
K
K
Department of Urology, School of Medicine, Kanazawa University, Japan.
Uchibayashi
T
T
Hasegawa
T
T
Lee
S W
SW
Ohkawa
M
M
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002467:Cell Nucleus / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D018308:Papilloma, Inverted / Q000235:genetics*; D012189:Retrospective Studies; D016196:S Phase; D014516:Ureteral Neoplasms / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm