Synthesis and cytotoxic activity against L1210 leukemia of new aminocyclopenta[c]thiophenones.
Synthesis of some new hydroxyaminocyclopenta[c]thiophenones was achieved via halogenation reaction, then formation and finally cleavage of an aziridino ring. The in vitro cytotoxic activity of these compounds was evaluated against L1210 leukemia. The importance of the ketohydroxyethylamino sequence for their activities is discussed.
Centre d'Etudes et de Recherche sur le Médicament de Normandie (Laboratoire de Chimie Thérapeutique) U.F.R. des Sciences Pharmaceutiques, Caen, France.
A
A
Alsaidi
S
S
al Shargapi
P
P
Dallemagne
F
F
Carreiras
P
P
Gauduchon
S
S
Rault
M
M
Robba
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013876:Thiophenes