Pulsatile LH-RH administration induces puberty in hypogonadotropic GH-deficient patients.
Three growth hormone (GH) deficient males with hypogonadotropic hypogonadism were treated with pulsatile luteinizing hormone-releasing hormone (LH-RH) administration. In two of them, the GH deficiency was idiopathic, but in the other it was secondary, caused by suprasellar germinoma. In response to LH-RH therapy, the serum testosterone (T), testicular volume, and body height increased in all three patients, and normal serum T levels and spermatogenesis were achieved in two patients. Gonadotropin responses to an LH-RH test preceding therapy did not seem to be an accurate predictor of the success of LH-RH therapy. We conclude that GH-deficient patients with hypogonadotropic hypogonadism can be expected to achieve normal pubertal development and spermatogenesis with pulsatile LH-RH administration.
Department of Child Development, Kumamoto University School of Medicine, Japan.
N
N
Iwatani
M
M
Kodama
T
T
Miike
D000293:Adolescent; D000328:Adult; D002648:Child; D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006062:Gonadotropins / Q000172:deficiency*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000150:complications* / Q000188:drug therapy; D008297:Male; D011628:Puberty, Delayed / Q000188:drug therapy* / Q000209:etiology; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D013006:Growth Hormone