[Gene expression and function of progesterone receptor isoforms].
Progesterone receptor is unique in terms of the existence of two isoforms of A and B. The isoforms are expressed by two distinct promoters in the peripheral as well as the brain. The 5'-untranslated region and the coding region around ATG 1 of rat progesterone receptor form B as well as the ligand binding domain are cloned. The function of the forms A and B is still unclear. However, it has been reported that the form A is a hormone-dependent transdominant repressor of the B function under certain circumstance of the cell. This model is very interesting to elucidate the molecular mechanism of progesterone action.
Department of Obstetrics & Gynecology, Yamanashi Medical University.
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Kato
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D015870:Gene Expression; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011980:Receptors, Progesterone / Q000235:genetics* / Q000502:physiology
D012333:RNA, Messenger; D011980:Receptors, Progesterone