[Multiple melanoma in xeroderma pigmentosum].
Xeroderma pigmentosum comprises a heterogeneous group of autosomal recessive hereditary diseases, which are characterized by a number of clinical characteristics and an abnormal DNA repair mechanism. Patients affected show a high frequency of mucocutaneous malignant tumors, especially squamous cell carcinomas and basal cell carcinomas. We report on a 65-year-old patient who successively developed a total of 15 malignant melanomas, 1 squamous cell carcinoma and 1 lymph node metastasis of a malignant melanoma. The clinical diagnosis of xeroderma pigmentosum was confirmed by the complementation analysis, which defined our patient as xeroderma pigmentosum of the complementation group D.
Hautklinik, Christian-Albrechts-Universität, Kiel.
R
R
Fölster-Holst
C
C
Schubert
E
E
Christophers
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D003241:Consanguinity; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008854:Microscopy, Electron; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014983:Xeroderma Pigmentosum / Q000235:genetics* / Q000473:pathology / Q000601:surgery
Multiple Melanome bei Xeroderma pigmentosum.