Autonomic disturbance in severe tetanus: failure of parenteral clonidine to control blood pressure.
In this paper we describe a typical case of tetanus and report our observations with the centrally acting alpha 2-adrenoreceptor agonist clonidine. Previous work with this agent has suggested that it may be of value in tetanus.
Brown
J L
JL
Unit of Infectious Diseases and Tropical Medicine, St Mary's Hospital Medical School, Northwick Park Hospital, Middlesex, U.K.
Sinding
H
H
Mathias
C J
CJ
D000368:Aged; D000369:Aged, 80 and over; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007275:Injections, Intravenous; D008297:Male; D010243:Paralysis / Q000209:etiology; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D013742:Tetanus / Q000150:complications* / Q000188:drug therapy
D003000:Clonidine; D010400:Penicillin G