Polarographic and absorptive stripping voltammetric determination of mitoxantrone, emodin and chrysarobin using mercury and glassy carbon electrodes.
Polarographic and voltammetric methods were used to study drugs of anthrone derivatives: mitoxandrone (antineoplastic), emodin (cathartic) and chrysarobin (antipsoriatic) on mercury and glassy carbon electrodes. The surface-active properties were exploited for developing a highly sensitive adsorptive stripping voltammetric method for determination of trace amounts of these compounds. Effective pre-concentration was obtained at glassy carbon electrode, with the surface species being measured via its reduction or oxidation, respectively. It was concluded that observed cathodic and anodic currents had the diffusive character. A simple, quick and accurate methods for the determination of all studied compounds in pure form and mitoxantrone in vials have been developed. The acetate buffer pH 4.6 containing 5 to 30% ethanol was used as a supporting electrolyte. The linear calibration range was 0.5 = 100 microg cm-3 on mercury and 25 - 250 ng cm-3 on glassy carbon electrode.
Drug Institute, School of Medicine, Warsaw, Poland.
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Fijałek
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D000873:Anthracenes / Q000032:analysis* / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D004563:Electrochemistry; D004566:Electrodes; D004642:Emodin / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008942:Mitoxantrone / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D011048:Polarography
D000873:Anthracenes; D000894:Anti-Inflammatory Agents, Non-Steroidal; C013883:chrysarobin; D008942:Mitoxantrone; D004642:Emodin