Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations.
Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days. A statistically significant decrease in mortality rate (P < 0.04) was observed in comparison to a retrospectively analysed group of 13 septic infants, who were treated in a comparative way but without the use of a pentoxifylline infusion. The suggestion that pentoxifylline may be an effective drug in the treatment of Gram-negative sepsis in premature infants should be tested in a double-blind, randomized study.
Neonatal Department, Jagiellonian University Medical College, Cracow, Poland.
R
R
Lauterbach
D
D
Pawlik
B
B
Tomaszczyk
B
B
Cholewa
D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D010431:Pentoxifylline / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy*; D015996:Survival Rate
D010431:Pentoxifylline