N-nitroso compounds, nitrite and pH in human fasting gastric juice.
Total N-nitroso compounds, ethyl acetate-extractable N-nitroso compounds and nitrite were measured in 146 samples of fasting gastric juice to investigate their relationship with pH. A positive correlation was found between pH and extractable N-nitroso compounds (r = 0.206, P < 0.02), whereas total N-nitroso compounds were pH-independent. It was inferred that pre-cancerous conditions associated with high gastric pH may be produced by an increase in the extractable N-nitroso compounds, which constitute only a small fraction of the total gastric N-nitroso compounds.
Hôpital Cochin, Paris, France.
B D
BD
Vu
J L
JL
Paul
M
M
Gaudric
J
J
Guerre
J
J
Yonger
O G
OG
Ekindjian
D000328:Adult; D005215:Fasting; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009573:Nitrites / Q000032:analysis*; D009603:Nitroso Compounds / Q000032:analysis*
D009573:Nitrites; D009603:Nitroso Compounds