[Acute leukemia: autologous transplantation of bone marrow cells grown in long-term culture containing low molecular weight natural tumour suppressor].
Fourteen patients with acute myelogenous leukemia and 3 patients with acute lymphoblastic leukemia in complete remission underwent autologous transplantation of their bone marrow cells in long-term culture containing low molecular weight-natural tumour suppressor. Their mean age was 27 years (9-35). Preparative regimen included cyclophosphamide and total body irradiation. All patients received no chemotherapy after transplantation. Follow-up for to 45 months showed that 11 patients remained disease-free survival (DFS) at 15 months, 8 at 24 months, 5 at 30 months, and 1 at 43 months. 5 patients relapsed between 6 and 22 months. One case died from sudden death at 6 months. 3.5-year DFS was 62.7 +/- 15.0%.
Department of Hematology, Beijing Army General Hospital of PLA.
K
K
Yang
A P
AP
Teng
Z T
ZT
Pei
D000293:Adolescent; D000328:Adult; D016465:Bone Marrow Purging / Q000379:methods; D016026:Bone Marrow Transplantation; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014182:Transplantation, Autologous