[The comparative efficacy of emoxipine and sodium oxybutyrate in experimental myocardial ischemia].
The efficacy of emoxypine (2-ethyl-6-methyl-3-hydroxypyridine chlorohydrate) versus sodium hydroxybutyrate in total and local ischemia followed by reperfusion was studied in the experiments on rat isolated hearts. Emoxypine in a dose of 1 nM in total ischemia was shown to have a protective action, by decreasing reperfusion contracture. In local ischemia, emoxypine, unlike sodium hydroxybutyrate, did not favour greater restoration of the amplitude of isolated heart contractions, but restored coronary flow and stabilized contraction frequency better than did sodium hydroxybutyrate.
S A
SA
Afanas'ev
E D
ED
Alekseeva
I B
IB
Bardamova
S A
SA
Bogomaz
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*
D000975:Antioxidants; D010847:Picolines; D012978:Sodium Oxybate; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Sravnitel'naia éffektivnost' émoksipina i oksibutirata natriia pri eksperimental'noĭ ishemii miokarda.