Hypersegmentation of neutrophils in the cerebrospinal fluid: report of a case with hematologic correlation and review of the literature.
Hypersegmented neutrophils can occasionally be seen in the cerebrospinal fluid (CSF) of patients with acute pyogenic meningitis, and rarely as an artifact of cytocentrifugation. We report a case of florid neutrophil hypersegmentation in cytocentrifuged CSF specimens from a patient presenting with anemia and mental status changes. Megaloblastic anemia was excluded by a thorough hematologic evaluation, and the patient was later found to have an epidural abscess. The striking hypersegmentation is attributed to the combined effects of meningeal infection and cytocentrifugation, and a review of the available limited literature on cytomorphologic alterations in CSF cells, specifically neutrophils, is presented.
Department of Pathology, University of North Carolina, Chapel Hill 27599-7525.
R D
RD
Lodge-Rigal
D B
DB
Novotny
D002467:Cell Nucleus / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000166:cytology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology* / Q000648:ultrastructure