Early changes in cerebral sodium distribution following ischaemia monitored by 23Na magnetic resonance imaging.
23Na magnetic resonance imaging has been used in this preliminary study to investigate early changes in brain sodium signal intensity during and after cerebral ischaemia in a gerbil model. The total sodium signal in selected brain regions decreased between 15 and 30% within 4 min of the onset of ischaemia, and then remained constant throughout the ischaemic period. The same pattern was observed in the eyes. On reperfusion, there was no significant change in the sodium signal over the first 4 min, but by 8 min the signal intensity had returned to or passed through control levels in all regions measured, with the exception of the eyes. These observations are consistent with the loss and resynthesis of ATP as seen in this model, and may be reflecting the redistribution of tissue sodium resulting from energy failure and recovery.
Department of Neurochemistry, Institute of Neurology, London, UK.
K L
KL
Allen
A L
AL
Busza
S R
SR
Williams
S C
SC
Williams
D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000175:diagnosis / Q000378:metabolism*; D005849:Gerbillinae; D008279:Magnetic Resonance Imaging; D008297:Male; D012964:Sodium / Q000378:metabolism*
D000255:Adenosine Triphosphate; D012964:Sodium