Efficacy of inactivated whole HIV-2 vaccines with various adjuvants in cynomolgus monkeys.
Twenty-one cynomolgus monkeys were immunized with whole inactivated HIV-2 preparations administered with various adjuvants (incomplete Freund's adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 100 MID50 of a homologous monkey-cell grown, cell-free HIV-2. Seven animals were completely protected against infection, three showed reduced virus replication. The vaccines elicited neutralizing and ADCC antibodies; the titers did not correlate with protection. Immunization with a whole inactivated vaccine can protect primates from intravenous challenge with a monkey-cell grown cell-free human immunodeficiency virus type 2.
Department of Immunology, Swedish Institute for Infectious Disease Control, Karolinska Institute, Stockholm.
P
P
Putkonen
C
C
Nilsson
L
L
Walther
L
L
Ghavamzadeh
K
K
Hild
K
K
Broliden
G
G
Biberfeld
R
R
Thorstensson
D016915:AIDS Vaccines / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control; D000276:Adjuvants, Immunologic; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002460:Cell Line; D005260:Female; D015752:Genes, env; D015750:Genes, gag; D015751:Genes, pol; D015483:HIV Antibodies / Q000097:blood*; D016325:HIV Long Terminal Repeat; D015498:HIV-2 / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D008198:Lymph Nodes / Q000821:virology; D008214:Lymphocytes / Q000821:virology; D008252:Macaca fascicularis; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D015164:Vaccines, Inactivated / Q000276:immunology*; D014779:Virus Replication
D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D015483:HIV Antibodies; D015164:Vaccines, Inactivated