Cervical cytomegalovirus infection in prostitutes and in women attending a sexually transmitted disease clinic.
This study aimed to determine the frequency of, and to define factors associated with, cervical shedding of cytomegalovirus (CMV) in highly sexually active women (licensed prostitutes) and in women attending a sexually transmitted disease (STD) clinic. Cervical specimens obtained from 195 licensed prostitutes and 187 STD patients aged 17-50 years were compared for the presence of cervical CMV with specimens from 70 women of the same ages attending a gynecologic clinic. Cervical CMV was identified by the presence of a CMV-specific immediate-early gene sequence amplified by the polymerase chain reaction. Cervical CMV prevalences of 38.9% and 34.8% were found for licensed prostitutes and STD patients, respectively. These rates were significantly higher than the 24.3% cervical CMV prevalence for women attending the gynecologic clinic. The data suggest that frequent sexual contact with many sexual partners is responsible for the high frequency of cervical CMV observed in licensed prostitutes. The interaction between CMV and urogenital bacterial infections is a plausible explanation for the high cervical CMV prevalence in STD patients.
Shen
C Y
CY
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
Chang
S F
SF
Lin
H J
HJ
Ho
H N
HN
Yeh
T S
TS
Yang
S L
SL
Huang
E S
ES
Wu
C W
CW
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002584:Cervix Uteri / Q000821:virology*; D003075:Coitus; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D008562:Membrane Glycoproteins; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D011477:Sex Work; D012749:Sexually Transmitted Diseases / Q000821:virology; D013624:Taiwan / Q000453:epidemiology; D015534:Trans-Activators; D002577:Uterine Cervical Diseases / Q000453:epidemiology / Q000821:virology*; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D017201:Virus Shedding
D004279:DNA, Viral; C069186:IE2 protein, Cytomegalovirus; D017874:Immediate-Early Proteins; D008562:Membrane Glycoproteins; D015534:Trans-Activators; C077406:UL115 protein, Human herpesvirus 5; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C071440:glycoprotein H, Cytomegalovirus; C499358:glycoprotein H, Human cytomegalovirus; C439068:glycoprotein O, cytomegalovirus