Genomic imprinting. Imprinting with and without methylation.
Methyltransferase-deficient mice reveal that DNA methylation is required for the somatic-cell maintenance of parental imprinting, which alters the expression of a gene according to the parent from which it was inherited.
Laboratory of Developmental Genetics and Imprinting, AFRC Babraham Institute, Cambridge, U.K.
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Reik
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Allen
D000818:Animals; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D018392:Genomic Imprinting; D008297:Male; D008745:Methylation; D008780:Methyltransferases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D017527:Receptor, IGF Type 2 / Q000235:genetics
D017527:Receptor, IGF Type 2; D004247:DNA; D008780:Methyltransferases