Refractory anemia with excess of blasts and isochromosome 12p in a patient with primary mediastinal germ-cell tumor.
Isochromosome(12p), a cytogenetic abnormality characteristic of germ-cell tumors, is exceedingly rare in hematologic disorders. The cytogenetic analysis of a patient diagnosed as refractory anemia with excess of blasts with an associated i(12p), who previously had a teratocarcinoma of the mediastinum, is presented. The cytogenetic analysis was performed at diagnosis of the hematologic malignancy, with all 30 metaphases in the bone marrow culture showing a 47,X, -Y, +8, +i(12)(p10) karyotype. The cytogenetic findings in this patient are compared with those published concerning the association of mediastinal germ-cell tumors and malignant hematologic disorders.
Laboratori de Citologia Hematològica, Hospital Central L'Aliança, Barcelona, Spain.
F
F
Solé
F
F
Bosch
S
S
Woessner
A
A
Pérez-Losada
F
F
Cervantes
E
E
Montserrat
L
L
Florensa
C
C
Rozman
D000293:Adolescent; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D018237:Germinoma / Q000235:genetics*; D006801:Humans; D018404:Isochromosomes / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D008479:Mediastinal Neoplasms / Q000235:genetics*