Modulation of glutathione depletion and lipid peroxidation by WR-77913 an 2-mercaptopropionylglycine in cyclophosphamide chemotherapy.
Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MPG or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
Department of Radiobiology, Kasturba Medical College, Manipal, India.
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Bhanumathi
P U
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Devi
D004999:Amifostine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008625:Tiopronin / Q000494:pharmacology*
C035284:WR 77913; D003520:Cyclophosphamide; D008625:Tiopronin; D005978:Glutathione; D004999:Amifostine