Origins of hepatomegaly produced by dexamethasone (DEX), pregnenolone 16 alpha-carbonitrile (PCN) and phenobarbitone (PB) in female Sprague-Dawley rats.
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, U.K.
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NJ
Thatcher
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Caldwell
D000818:Animals; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003907:Dexamethasone / Q000633:toxicity*; D004790:Enzyme Induction; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D010634:Phenobarbital / Q000633:toxicity*; D011285:Pregnenolone Carbonitrile / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011285:Pregnenolone Carbonitrile; D003907:Dexamethasone; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019392:Cytochrome P-450 CYP2E1; D010634:Phenobarbital