Modulatory influence of oral contraceptives on mammary growth pattern of normal and ovariectomised mice.
The present study reports the modulatory influence of oral contraceptive formulations, Ovral (0.05 mg ethinylestradiol plus 0.5 mg norgestrel per pill), Noracycline (0.05 mg ethinylestradiol plus 0.1 mg lynestrenol per pill), Pearl (0.03 mg ethinylestradiol plus 0.30 mg norgestrel) and Centchroman (30 mg), on the growth and developmental pattern of murine mammary epithelium in normal as well as ovariectomised mice. Oral treatments of ovariectomised mice for 15 days with doses D1 (1/5th of a pill) and D2 (1/10th of a pill) of Ovral, Noracycline and Pearl enhanced the diameter of the terminal end buds (TEBS) and lateral buds (LBS) significantly. The increase in the diameters of TEBS and LBS on treatment with similar doses of Centchroman were not much significant. Hence, it may be concluded from the present study that the growth and development pattern of mammary epithelium can be modulated by treatment with oral contraceptives Oral, Noracycline, Pearl and Centchroman which is indicated by the increase in the diameters of TEBS and LBS.
Cancer Biology Laboratory, School of Life Sciences, Jawahar Lal Nehru University, New Delhi, India.
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D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D002486:Centchroman / Q000494:pharmacology; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004338:Drug Combinations; D004848:Epithelium / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000494:pharmacology; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D008234:Lynestrenol / Q000494:pharmacology; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000254:growth & development; D008656:Mestranol / Q000494:pharmacology; D051379:Mice; D009644:Norgestrel / Q000494:pharmacology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology
D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D002486:Centchroman; D009644:Norgestrel; D004997:Ethinyl Estradiol; C002746:Noracycline; D019304:Ethinyl Estradiol-Norgestrel Combination; D008656:Mestranol; D008234:Lynestrenol