Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx.
Tumor-associated tissue eosinophilia (TATE) has been previously reported to be associated with a favorable prognosis for a variety of carcinomas, including head and neck cancer. We have examined this relationship in a series of 104 patients with laryngeal cancer who were observed for 5 years or more. Patients were followed up for a minimum of 5 years or until death. The original laryngeal biopsy histologic slides were examined and graded for TATE. Tumor-associated tissue eosinophilia was absent in 73 of the 104 biopsy specimens, and 25 of these 73 patients died directly of laryngeal carcinoma within 5 years. In all, 31 patients had TATE and only 3 subsequently died of laryngeal carcinoma within 5 years (P = 0.009, chi-square test). It appears, therefore, that TATE is associated with a good long-term prognosis for laryngeal carcinoma.
Thompson
A C
AC
Department of Otolaryngology/Head and Neck Oncology, University Hospital, Nottingham, United Kingdom.
Bradley
P J
PJ
Griffin
N R
NR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000401:mortality* / Q000473:pathology; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate