Possible transmission of sarcoidosis via allogeneic bone marrow transplantation.
Allogeneic bone marrow transplantation (BMT) was performed in a 34-year-old man for non-Hodgkin's lymphoma. Two years before bone marrow harvest, pulmonary sarcoidosis was diagnosed in the donor. After steroid therapy, disease of the donor was in clinical remission with only minor radiological signs at the time of BMT. On day 90 after BMT, active sarcoidosis was diagnosed in the recipient. Besides radiologic signs and increased angiotensin converting enzyme levels, diagnosis was proved by characteristic histologic changes in lung and liver biopsies. Immunosuppressive therapy was changed from high dose cyclosporine to high dose methylprednisolone and symptoms promptly resolved within 10 weeks. This case indicates the possibility of transmission of sarcoidosis by marrow transplantation.
Heyll
A
A
Department of Internal Medicine, University of Düsseldorf, Germany.
Meckenstock
G
G
Aul
C
C
Söhngen
D
D
Borchard
F
F
Hadding
U
U
Mödder
U
U
Leschke
M
M
Schneider
W
W
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014184:Transplantation, Homologous
D016572:Cyclosporine; D008775:Methylprednisolone