Synthesis and hypotensive activity of some heterocyclic analogues of GYKI-12 743.
[1,4]Benzodioxanylmethyl-, [1,4]benzodioxanylmethylaminopropyl- and phenoxyethylaminoethyl-substituted lactams were synthesised and their hypotensive activity was investigated. Some of these compounds show moderate to high hypotensive effect, but they had more toxic and/or side effects than GYKI-12 743.
Institute for Drug Research, Budapest, Hungary.
P
P
Mátyus
E
E
Kasztreiner
E
E
Diesler
A
A
Behr
I
I
Varga
J
J
Kosáry
G
G
Rabloczky
L
L
Jaszlits
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000959:Antihypertensive Agents; D004146:Dioxanes; D011724:Pyridazines; C064892:GYKI 12743