Identification, characterization, and physical mapping of 14 polymorphic simple sequence repeat markers on human chromosome 21.
Fourteen new dinucleotide repeat polymorphisms specific for human chromosome 21 have been identified, mapped, and characterized. The average heterozygosity of all markers was 0.66. The average PIC value was 0.61. The markers were mapped by STS content mapping of YACs previously assigned to chromosome 21. The correlation of polymorphic genetic markers with substantially complete physical maps should facilitate the identification of loci of interest on chromosome 21.
Human Genome Center, Lawrence Berkeley Laboratory, Berkeley, California 94720.
S R
SR
Lowry
K
K
Wilson
R
R
Blazej
J
J
Chiu
J
J
Rine
E A
EA
Ostrander
D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002891:Chromosomes, Human, Pair 21; D017931:DNA Primers; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid
D017931:DNA Primers; D005819:Genetic Markers