The LIM domain: a new structural motif found in zinc-finger-like proteins.
An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.
Sánchez-García
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Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Rabbitts
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D000595:Amino Acid Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D011506:Proteins