Comparative evaluation of determination of beta-lactam intermediates.
The Schiff's base formation between 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-aminocephalosporanic acid and p-dimethylaminobenzaldehyde (PDAB) was investigated. The factors that affect the reaction such as concentration of PDAB, time and pH were studied and optimised for estimation of these intermediates.
Deshpande
B S
BS
Hindustan Antibiotics Limited, Pimpri, Pune.
Ambedkar
S S
SS
Shewale
J G
JG
D001547:Benzaldehydes / Q000737:chemistry*; D002138:Calibration; D002511:Cephalosporins / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000737:chemistry; D007700:Kinetics; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*
D001547:Benzaldehydes; D002511:Cephalosporins; D007202:Indicators and Reagents; D012545:Schiff Bases; D010397:Penicillanic Acid; C014320:7-aminodesacetoxycephalosporanic acid; C004408:aminopenicillanic acid; C510241:p-dimethylaminobenzaldehyde