Could the defect in type II diabetes mellitus be the absence of a postprandial alkalosis?
Perhaps the liver following a meal has a significant change in pH. Insulin binding and several enzymes important in the postprandial state for processing lipids, proteins and carbohydrates all appear to have alkaline optimal pH levels. Diabetes mellitus type II could be due to the liver failing to obtain the optimum pH for insulin binding.
Endocrinology Dept, Brooke Army Medical Center, San Antonio, Texas 78234.
K
K
Carlin
S
S
Carlin
D000471:Alkalosis / Q000378:metabolism; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D004435:Eating / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological
D007328:Insulin