[The participation of intracellular regulatory systems in the reactions of the cat cerebral cortical neurons to fosfakol].
The effects of paraoxon (1.5-4.5 LD50) on the levels of intracellular regulatory components, such as membrane-bound calcium (Ca(b)) and polyphosphoinositides (PPI) were studied along with microcirculation and neuronal bioelectric activity control in the feline cerebral cortex. There was a relation between these parameters, which supports the important role of Ca(b) and PPI in the mechanism of paraoxon's neurotoxic action. Taking into account the findings, it is advisable to use a complex of drugs in organophosphate intoxication, which will correct the mechanisms of intracellular signal transduction.
Samoĭlov
M O
MO
Sofronov
G A
GA
Kamenev
A L
AL
Semenov
D G
DG
Tiul'kova
E I
EI
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002415:Cats; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010261:Paraoxon / Q000494:pharmacology; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism
D018129:Phosphatidylinositol Phosphates; D010261:Paraoxon; D002118:Calcium
Uchastie vnutrikletochnykh reguliatornykh sistem v reaktsiiakh neĭronov kory golovnogo mozga koshki na fosfakol.