Hormone conference at Sahlgren's University Hospital: polycythemia and inappropriately high serum erythropoietin concentration in a 62-year-old man.
A 62-year-old man with a history of coronary insufficiency complained at his scheduled visit to the outpatient clinic of symptoms suggestive of gastritis. His blood hemoglobin concentration, however, was markedly increased. Results of a hematological work-up suggested an erythropoietin-producing tumor. Signs of increased intracranial pressure then led to the finding of a cerebellar tumor, which could explain his vertigo and abdominal symptoms. This cystic capillary hemangioblastoma probably was responsible for the erythropoietin production and also seemed to produce basic fibroblast growth factor. The clinical evaluation of polycythemia as well as erythropoietin biochemistry and clinical application are reviewed.
Department of Clinical Chemistry, Gothenburg University, Sahlgren's University Hospital, Sweden.
G
G
Lindstedt
P A
PA
Lundberg
A
A
Norrby
J
J
Kutti
O
O
Andersen
K E
KE
Jakobsson
C
C
Nordborg
B A
BA
Bengtsson
D002196:Capillaries / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000150:complications / Q000175:diagnosis*; D004921:Erythropoietin / Q000097:blood*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D018325:Hemangioblastoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011086:Polycythemia / Q000209:etiology*
D016222:Fibroblast Growth Factor 2; D004921:Erythropoietin