[The new anti-alcohol preparation medikhronal: changes in the level of ethanol, acetaldehyde and monoamines during the treatment of alcoholism patients].
Treating patients with stage-II alcoholism with medichronal and unithiol sharply decreases blood levels of alcohol and acetaldehyde. Medichronal restores the decreased level of norepinephrine excretion in 25% of patients and the increased level of epinephrine in 43%. The high baseline concentration of serotonin dropped in 41%, however, its level remained higher than in the controls. There was a negative correlation between the changes of ethanol concentrations and the excretion of norepinephrine. There was a direct dependence between the changes in the norepinephrine/epinephrine ratio and the serotonin concentration.
Bozhko
G Kh
GKh
Voloshin
P V
PV
Boĭko
T P
TP
Kostiukovskaia
L S
LS
Kholodnyĭ
Iu G
IuG
Markozova
L M
LM
Bolotova
Z N
ZN
D000079:Acetaldehyde / Q000097:blood*; D000328:Adult; D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D015306:Biogenic Monoamines / Q000378:metabolism*; D004338:Drug Combinations; D004341:Drug Evaluation; D000431:Ethanol / Q000097:blood*; D005561:Formates / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D005998:Glycine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013997:Time Factors
D000427:Alcohol Deterrents; D015306:Biogenic Monoamines; D004338:Drug Combinations; D005561:Formates; C088648:medikhronal; D000431:Ethanol; D000079:Acetaldehyde; D005947:Glucose; D005998:Glycine
Novyĭ antialkogol'nyĭ preparat medikhronal: izmenenie soderzhaniia étanola, atsetal'degida i monoaminov pri lechenii bol'nykh alkogolizmom.