Enhanced responses of rat dorsal horn neurons after UV irradiation of the hindpaw; roles of the NMDA receptor.
Recordings were made from nociceptive dorsal horn neurones in the anaesthetized rat 3 and 5 days after ultraviolet (UV) irradiation of the hindpaw. The electrically evoked A beta-fibre-evoked responses from the paw were enhanced and their thresholds were lowered. Spontaneous neuronal activity was increased but the C-fibre-evoked responses were unaltered. These enhanced responses, suggestive of allodynia, were reduced by N-methyl-D-aspartate receptor (NMDA) antagonism.
Chapman
V
V
Department of Pharmacology, University College London, UK.
Dickenson
A H
AH
D000200:Action Potentials / Q000528:radiation effects; D000704:Analysis of Variance; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000528:radiation effects*; D005260:Female; D006614:Hindlimb / Q000294:innervation*; D007278:Injections, Spinal; D007736:Kynurenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009474:Neurons / Q000502:physiology / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D012684:Sensory Thresholds; D013116:Spinal Cord / Q000502:physiology / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays
D016194:Receptors, N-Methyl-D-Aspartate; D007736:Kynurenic Acid; C057013:7-chlorokynurenic acid