Ciprofloxacin resistant Serratia marcescens endocarditis as a complication of non-Hodgkin's lymphoma.
We report a case of endocarditis caused by a ciprofloxacin-resistant strain of Serratia marcescens in a 50-year-old female neutropenic patient with non-Hodgkin's lymphoma which occurred while receiving ciprofloxacin prophylaxis. She made poor progress on first line therapy with azlocillin and gentamicin by bolus injection t.d.s. The infection was finally eliminated by a regimen of continuous infusion of azlocillin and once daily gentamicin.
Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on-Trym, Bristol, U.K.
R J
RJ
Körner
A
A
Nicol
D S
DS
Reeves
A P
AP
MacGowan
J
J
Hows
D001390:Azlocillin / Q000008:administration & dosage / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004697:Endocarditis, Bacterial / Q000209:etiology*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008875:Middle Aged; D016868:Serratia Infections / Q000209:etiology*; D012706:Serratia marcescens / Q000187:drug effects*
D005839:Gentamicins; D002939:Ciprofloxacin; D001390:Azlocillin