Eosinophilic enterocolitis diagnosed by means of technetium-99m albumin scintigraphy and treated with budesonide (CIR).
A patient with a 15 year history of diarrhoea of unknown origin is described. Scintigraphy with technetium-99m labelled albumin suggested albumin loss at the terminal ileum and caecum; subsequent colonoscopic biopsies of these macroscopically normal looking areas showed abundant infiltration with eosinophils. A diagnosis of eosinophilic enterocolitis was made. Treatment with prednisolone had good results, but had to be stopped because of severe side effects. Oral cromoglycate and mesalazine were not effective. Budesonide (CIR), a new topically active corticosteroid with very little systemic effects, was at least as effective as prednisolone without producing side effects.
Russel
M G
MG
Department of Gastroenterology, University Hospital Maastricht, The Netherlands.
Zeijen
R N
RN
Brummer
R J
RJ
de Bruine
A P
AP
van Kroonenburgh
M J
MJ
Stockbrügger
R W
RW
D000328:Adult; D019819:Budesonide; D003967:Diarrhea / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004760:Enterocolitis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D004802:Eosinophilia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D011282:Pregnenediones / Q000627:therapeutic use; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
D011282:Pregnenediones; D013668:Technetium Tc 99m Aggregated Albumin; D019819:Budesonide