[Acute ischemia of an arm as an unusual manifestation of ergotism].
A 27-year-old woman developed acute pain, pallor and feeling of cold in her left arm. She had been a smoker of 15-20 cigarettes daily since the age of 15 years, but had not previously had any serious illness. In addition to contraceptives she had had been taking one to several suppositories containing caffeine and ergotamine tartrate (2 mg) daily against migraine. Angiological examination 5 days after onset of symptoms discovered a weak brachial pulse low in the left upper arm, while ulnar and radial pulses were absent. All other pulses were normally palpable. Colour duplex sonography demonstrated occlusion of the brachial artery which angiographically was due to a 5 cm severe narrowing without thrombus, blood flowing distally via collaterals. No improvement was achieved by local injection of 100,000 IU urokinase, 0.5 mg nitroglycerin, 20 mg tolazoline and a 3-hour infusion of alprostadil. On infusion of 560 ml hydroxyethylstarch over 8 hours, 400 mg naftidrofuryl, therapeutic doses of heparin and abstinence from ergotamine (since admission) the vessel diameter increased by 50% within 23 hours and after a further 24 hours to almost 100% of the comparable arterial segment of the right arm while merely on heparin infusion.
Heinz
M
M
I. Medizinische Klinik, Technische Universität München.
Theiss
W
W
Golder
W
W
Schömig
A
A
D000208:Acute Disease; D000328:Adult; D001132:Arm / Q000098:blood supply*; D001916:Brachial Artery / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004878:Ergotamine / Q000008:administration & dosage / Q000009:adverse effects; D004881:Ergotism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008881:Migraine Disorders / Q000517:prevention & control; D013488:Suppositories
D004338:Drug Combinations; D013488:Suppositories; D002110:Caffeine; D004878:Ergotamine
Akute Ischämie eines Armes als ungewöhnlicher Ausdruck eines Ergotismus.