Mitomycin C as adjunctive therapy with glaucoma implant surgery.
Twenty-one eyes of 21 patients with refractory glaucoma underwent glaucoma surgery involving placement of a modified Molteno implant and intraoperative application of mitomycin C. Sixteen eyes (76.2%) had an intraocular pressure (IOP) of 21 mm Hg or less after a mean follow up of 9.4 +/- 6.4 months; additional medication was needed in six eyes. Major complications included early flat anterior chamber (42.9%), implant plate erosion (9.5%), tube erosion (4.8%), late hypotony (4.8%), tube-corneal touch (4.8%), and phthisis bulbi after choroidal hemorrhage (4.8%). Only one patient had a high IOP due to decreased filtration through the implant. These results suggest that glaucoma implant surgery with the adjunctive use of mitomycin C may be useful in eyes with refractory glaucoma.
Department of Ophthalmology, Albert Einstein Israelite Hospital, São Paulo, Brazil.
R
R
Susanna
M T
MT
Nicolela
W Y
WY
Takahashi
D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D017024:Chemotherapy, Adjuvant; D005260:Female; D005355:Fibrosis / Q000188:drug therapy; D005500:Follow-Up Studies; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D018465:Molteno Implants; D011183:Postoperative Complications / Q000188:drug therapy; D011379:Prognosis; D012826:Silicone Elastomers
D001672:Biocompatible Materials; D012826:Silicone Elastomers; D016685:Mitomycin