Prenatal ultrasonographic diagnosis of fetal cerebral ventriculitis associated with asymptomatic maternal cytomegalovirus infection.
Cytomegalovirus is the most common cause of congenital viral infection. In utero infection is usually suspected in patients with growth-retarded fetuses or when maternal illness precipitates serological investigations. A case is presented where routine ultrasound examination at 30 weeks' gestation in an asymptomatic patient demonstrated mild fetal ventriculomegaly. Transvaginal ultrasound enabled the visualization of intraventricular adhesions and small periventricular cysts. The suspected diagnosis of in utero cytomegalovirus infection was confirmed by the presence of IgM antibodies in fetal blood and subsequently by isolation of the virus from the infant's urine. The presence of mild fetal ventriculomegaly should prompt transvaginal brain imaging.
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
R
R
Achiron
O
O
Pinhas-Hamiel
S
S
Lipitz
Z
Z
Heiman
B
B
Reichman
S
S
Mashiach
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000821:virology; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000821:virology; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D016216:Ultrasonography, Prenatal; D014556:Urine / Q000382:microbiology
D000914:Antibodies, Viral; D007075:Immunoglobulin M