The role of histamine in brain oedema formation.
The effects of histamine on the cerebral endothelial cells were studied. To determine if the extent of brain oedema formation could be reduced with histamine receptor antagonists, mepyramine (H1-receptor blocker), metiamide, cimetidine and ranitidine (H2-receptor antagonists) were administered at a dose of 5 mg/kg body weight 4, 2 and 0 h before the onset of experimental pneumothorax induced in newborn piglets. Mepyramine and ranitidine given 2 h before the induction of EBP prevented the accumulation of water, sodium and albumin in samples taken from the parietal cortex. In other experiments, carried out on Sprague-Dawley rats of CFY strain after permanent bilateral common carotid ligation (BCCL), the accumulation of water and sodium in the ischemic brain tissue could also be prevented in a dose dependent manner by intraperitoneal injections of ranitidine given 30 min before the surgery. Taken together, these results provide pharmacological evidence for the involvement of histamine receptors in the pathogenesis of brain oedema. Consequently, the use of histamine receptor blockers both in the prevention and in the treatment of brain oedema can be recommended.
Laboratory of Molecular Neurobiology, Biological Research Center, Szeged, Hungary.
F
F
Joó
J
J
Kovács
P
P
Szerdahelyi
P
P
Temesvári
A
A
Tósaki
D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D001929:Brain Edema / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology*; D008297:Male; D010296:Parietal Lobe / Q000187:drug effects / Q000503:physiopathology; D011292:Premedication; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology; D013552:Swine; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D006633:Histamine Antagonists; D011968:Receptors, Histamine; D006632:Histamine; D011899:Ranitidine