Activation and suppression of fibroblast function.
The fibroblast is the central player in the wound repair and scarring processes that occur in the anterior segment of the eye. Glaucoma filtration surgery is the ultimate example of the importance of the wound healing process, as this process is the major determinant of the success of this procedure. We highlight the role of the fibroblast, and discuss some of the growth factors stimulating fibroblast proliferation, migration and extracellular matrix production in the wound environment. We also review current methods of suppressing fibroblast proliferation, the new concepts that have arisen from laboratory studies, and future directions of investigation and treatment.
Khaw
P T
PT
Institute of Ophthalmology/Moorfields Eye Hospital, London, UK.
Occleston
N L
NL
Schultz
G
G
Grierson
I
I
Sherwood
M B
MB
Larkin
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D003864:Depression, Chemical; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D016212:Transforming Growth Factor beta / Q000494:pharmacology; D017211:Treatment Failure; D014945:Wound Healing / Q000502:physiology*
D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor