The effects of thyroid hormones on the heart following global ischemia. A clinical and experimental study.
Cardiopulmonary bypass is associated with a reduction in plasma thyroid hormone concentrations in patients undergoing cardiac surgery. However, studies of the effects of cardiopulmonary bypass on thyroid function are limited and many studies report conflicting data concerning only the period of cardiopulmonary bypass. In this study, we tried to clinically determine the effects of cardiopulmonary bypass on concentrations of thyroid hormones by comprehensive thyroid function tests in 10 patients before and after surgery, and observed the benefits of triiodothyronine supplementation after global ischemia on myocardial function experimentally in guinea pigs. In patients undergoing surgery, concentrations of total triiodothyronine and free triiodothyronine decreased progressively on the institution of cardiopulmonary bypass and remained below normal levels until 24 hours postoperatively. In the guinea pig hearts studied in a Langendorf perfusion apparatus, T3 supplementation enhanced percentage recovery of ventricular contractile force, heart work and heart rate with respect to other groups receiving no T3 supplementation or T3 supplementation without any ischemic interval.
Sinci
V
V
Department of Cardiovascular Surgery, Gazi University, School of Medicine, Ankara, Turkey.
Soncul
H
H
Gunaydin
S
S
Halit
V
V
Gokgoz
L
L
Tatlican
O
O
Yener
A
A
Bilgehan
A
A
Ersoz
A
A
D000368:Aged; D000818:Animals; D002303:Cardiac Output, Low / Q000517:prevention & control; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005947:Glucose; D006168:Guinea Pigs; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood*; D014284:Triiodothyronine / Q000494:pharmacology*; D014325:Tromethamine; D016276:Ventricular Function
C074097:Krebs-Henseleit solution; D013963:Thyroid Hormones; D014325:Tromethamine; D014284:Triiodothyronine; D005947:Glucose