Knemometry.
Knemometry provides a powerful tool for observation of short-term growth patterns. Failure of response to growth-promoting therapies in the short term predicts a poor statural response, but the relationship of the lower leg growth suppression seen with oral and inhaled corticosteroids, and the clinical implications in the longer term, remain unclear. The accumulating evidence suggests that there are measurable biochemical and clinical effects with some inhaled corticosteroids (e.g. beclomethasone dipropionate and budesonide), when given at the upper end of the recommended conventional dose range (18) and for long-term prophylaxis, and certainly at the higher starting doses. It is imperative, therefore, that all children receiving inhaled corticosteroids should have their growth monitored carefully and that the lowest effective dose of corticosteroid should be used.
Sheffield Children's Hospital, U.K.
C
C
MacKenzie
D000280:Administration, Inhalation; D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000886:Anthropometry / Q000295:instrumentation* / Q000379:methods; D002675:Child, Preschool; D006801:Humans; D007866:Leg / Q000033:anatomy & histology / Q000254:growth & development* / Q000473:pathology
D000305:Adrenal Cortex Hormones