Heat shock-induced reactivation of herpes simplex virus type 1 in latently infected mouse trigeminal ganglion cells in dissociated culture.
An in vitro herpes simplex virus type 1 (HSV-1) latency model was established, using trigeminal ganglia from latently infected mice. When heat-treated at 43 degrees C for 3 h, reactivation followed in 76.6% of the cultures, while reactivation was not observed in non-heat-treated controls.
Moriya
A
A
Department of Microbiology, Kyoto Prefectural University of Medicine, Japan.
Yoshiki
A
A
Kita
M
M
Fushiki
S
S
Imanishi
J
J
D000818:Animals; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000254:growth & development*; D006358:Hot Temperature; D007700:Kinetics; D051379:Mice; D009474:Neurons / Q000821:virology*; D013997:Time Factors; D012668:Trigeminal Ganglion / Q000821:virology*; D014709:Vero Cells; D014775:Virus Activation