Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma.
A 66-year-old woman presented clinical findings of Eaton-Lambert (myasthenic) syndrome (ELS). Fifteen months later, large-cell pulmonary carcinoma was detected. After systemic chemotherapy and radiotherapy, the tumor regressed and neurologic function improved. Although ELS is usually associated with pulmonary small-cell carcinoma, a minority of tumors are of squamous or glandular differentiation. We believe this is the first case report of ELS associated with large-cell neuroendocrine carcinoma in the English language literature, and it illustrates the importance of an aggressive approach to diagnosis and treatment.
Demirer
T
T
Division of Oncology (Fred Hutchinson Cancer Research Center), University of Washington, Seattle, WA.
Ravits
J
J
Aboulafia
D
D
D000368:Aged; D018287:Carcinoma, Large Cell / Q000150:complications* / Q000188:drug therapy; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000175:diagnosis; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy