[The effect of long-term cyclosporin and prednisone therapy on insulin secretory reserve].
Insulin secretory reserve assessed by the method of glucose potentiation of arginine induced insulin secretion is decreased in non-diabetic transplant recipients using triple immunosuppressive therapy with prednisone, cyclosporine, and azathioprine. To determine whether this defect is due to the combined therapy or to a single agent, we examined the acute insulin response (AIR) to arginine at 5 levels of glucose (basal and 4 levels achieved by continuous glucose infusions) in 7 normoglycemic arthritis patients (AP) using long term prednisone (10.3 +/- 37 mg for 83 +/- 37 months), and 4 normoglycemic psoriasis patients (PP) using long term cyclosporine (350 +/- 61 mg for 25 +/- 4 months) and compared them with matched healthy controls (CON). Long-term cyclosporine (ANOVA p = 0.016 compared to control subjects) but not prednisone treatment decreased insulin secretory reserve. We conclude that cyclosporine might have an adverse effect on beta-cell function and contribute to posttransplant diabetes.
Department of Medicine, University of Minnesota, Minneapolis.
A U
AU
Teuscher
E R
ER
Seaquist
M R
MR
Pittelkow
R P
RP
Robertson
D000328:Adult; D000704:Analysis of Variance; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D016572:Cyclosporine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D016572:Cyclosporine; D001120:Arginine; D011241:Prednisone
Einfluss von Cyclosporin- und Prednisondauertherapie auf die Insulinsekretionsreserve.