Evaluation of Salmonella porins as a broad spectrum vaccine candidate.
Porins were prepared from smooth strain of Salmonella typhi 0-901 and chemotype of rough mutant of S. typhimurium Ra-30. Mice were immunized with both the porin preparations in different groups and challenged with S. typhimurium LT2-71 and S. enteritidis SH-1269. Porin immunized mice showed significant protection (P < 0.01) against challenge with homologous as well as heterologous strains. Hence, the use of porins may be attempted in future to protect against salmonellosis.
Tabaraie
B
B
Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Sharma
B K
BK
Sharma
P R
PR
Sehgal
R
R
Ganguly
N K
NK
D000818:Animals; D001428:Bacterial Vaccines; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D051379:Mice; D018272:Porins / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D014611:Vaccination
D001428:Bacterial Vaccines; D007106:Immune Sera; D018272:Porins