[Effects of nifedipine on hepatic hyaluronic acid, hydroxyproline and glucosaminidase contents in rats with liver fibrosis].
In early stage treatment groups, Nifedipine (Nif) could significantly reduce hepatic hyaluronic acid (HA) and hydroxyproline (Hyp) contents in rats in which liver fibrosis had been induced by CCl4 treatment. N-acetyl-beta-glucosaminidase (beta-NAG) activity showed a similar change in the high dosage group. In late stage treatment groups, HA was reduced markedly, and decreased beta-NAG levels were noted in the high dosage group. These effects on HA, Hyp and beta-NAG were dependent on Nif dosage. The results suggest that Nif could inhibit the development of liver fibrosis in rats, and may even reverse it.
Che
J
J
Xin Hua Hospital, Shanghai Second Medical University.
Lu
H
H
Li
D
D
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D004305:Dose-Response Relationship, Drug; D006909:Hydroxyproline / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000118:Acetylglucosaminidase; D009543:Nifedipine; D006909:Hydroxyproline