P300 from an auditory oddball task: inter-laboratory consistency.
Event-related potentials (ERPs) were recorded from normal subjects for the purpose of evaluating measurement consistency among six laboratories located in different cities within the United States. At each laboratory location 15 male subjects were tested using a simple auditory stimulus discrimination task and identical electrophysiological equipment and recording methods. Assessment of the N1, P2, N2, and P3(00) potentials from both the target and standard stimuli resulted in no reliable differences among laboratories for component amplitudes, latencies, and scalp distributions. Quantitative evaluation of overall waveform and specific component morphology yielded good to excellent agreement across laboratories. The findings suggest that large-scale inter-laboratory human electrophysiological studies are feasible and may prove of value when using ERPs to evaluate cognitive function in humans.
Alexander
J E
JE
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Polich
J
J
Bloom
F E
FE
Bauer
L O
LO
Kuperman
S
S
Rohrbaugh
J
J
Morzorati
S
S
O'Connor
S J
SJ
Porjesz
B
B
Begleiter
H
H
D000328:Adult; D000704:Analysis of Variance; D004192:Discrimination, Psychological / Q000502:physiology; D004566:Electrodes; D004569:Electroencephalography; D004585:Electrooculography; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D008297:Male; D015588:Observer Variation; D012016:Reference Values; D014481:United States; D014796:Visual Perception / Q000502:physiology