Comparison of serum osteocalcin with total and bone specific alkaline phosphatase and urinary hydroxyproline:creatinine ratio in patients with Paget's disease of bone.
Osteocalcin or bone Gla protein (BGP) is secreted by osteoblasts, and its serum concentration is elevated in a number of conditions with high bone turnover. A comparison of serum osteocalcin with total (TALP) and bone specific alkaline phosphatase (BALP) and urinary hydroxyproline/creatinine (OHP/Cr ratio) was performed in 13 patients with active Paget's disease of bone. BGP did not correlate significantly with either BALP or TALP, but did show a significant correlation with OHP/Cr ratio (r = 0.76; P < 0.01). BGP does not appear to be as sensitive a marker as BALP or TALP in Paget's disease.
Department of Chemical Pathology, Leicestershire District Pathology Service, Leicester Royal Infirmary, UK.
I M
IM
Kaddam
S J
SJ
Iqbal
S
S
Holland
M
M
Wong
D
D
Manning
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D001846:Bone Development / Q000502:physiology; D001862:Bone Resorption / Q000097:blood; D001842:Bone and Bones / Q000201:enzymology; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood / Q000175:diagnosis / Q000652:urine*; D015675:Osteocalcin / Q000097:blood*; D012044:Regression Analysis
D015675:Osteocalcin; D003404:Creatinine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline