Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis.
High-strength pancreatic enzymes have recently been implicated as a cause of colonic strictures in children with cystic fibrosis (CF). We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.
McHugh
K
K
Department of Radiology, John Radcliffe Hospital, Headington, Oxford, UK.
Thomson
A
A
Tam
P
P
D002675:Child, Preschool; D003106:Colon / Q000000981:diagnostic imaging / Q000473:pathology*; D003108:Colonic Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003550:Cystic Fibrosis / Q000188:drug therapy*; D005355:Fibrosis; D005500:Follow-Up Studies; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D010194:Pancreatin / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography
D010194:Pancreatin