Monitoring living tissues by electrical impedance spectroscopy.
Solving the experimental difficulties associated with measurement of the electrical impedance of living tissues gives access to valuable tissue compartment parameters which are sensed within seconds using minimally invasive, simple metallic electrodes. Extracellular conductivity and cell membrane capacitance can be followed over time under conditions of metabolic toxicity, perfusion loss and thermal stress in liver, brain cortex, and muscle, respectively. Application of this technique in burns therapy allows an accurate estimation of the severity of thermal injury to skeletal muscle, supporting predictions on tissue survival.
Department of Occupational Health, Faculty of Medicine, McGill University, Royal Victoria Hospital, Montreal, Québec, Canada.
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Héroux
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Bourdages
D000818:Animals; D001929:Brain Edema / Q000503:physiopathology; D002056:Burns / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D017097:Electric Impedance; D004594:Electrophysiology; D005110:Extracellular Space / Q000502:physiology*; D007649:Ketamine / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008954:Models, Biological; D008991:Monitoring, Physiologic / Q000379:methods; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010424:Pentobarbital / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D014991:Xylazine / Q000633:toxicity
D014991:Xylazine; D007649:Ketamine; D010424:Pentobarbital