Use of Monte Carlo simulation for human exposure assessment at a superfund site.
This work presents a comparison of probabilistic and deterministic health risk estimates based on data from an industrial site in the northeastern United States. The risk assessment considered exposures to volatile solvents by drinking water ingestion and showering. Probability densities used as inputs included concentrations, contact rates, and exposure frequencies; dose-response inputs were single values. Deterministic risk estimates were calculated by "reasonable maximum exposure" (RME) approach recommended by the EPA Superfund program. The RME noncarcinogenic risk fell between the 90th and the 95th percentile of the probability density; the RME cancer risk fell between the 95th percentile and the maximum. These results suggest that in this case (1) EPA's deterministic RME risk was reasonably protective, (2) results of probabilistic and deterministic calculations were consistent, and (3) commercially available software Monte Carlo software effectively provided multiple risk estimates recommended by recent EPA guidance.
United States Environmental Protection Agency, Philadelphia, Pennsylvania 19107.
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D000328:Adult; D002273:Carcinogens / Q000032:analysis; D002648:Child; D003198:Computer Simulation; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D009010:Monte Carlo Method; D009511:New England; D018570:Risk Assessment; D012997:Solvents / Q000009:adverse effects* / Q000032:analysis; D013997:Time Factors; D014481:United States; D014484:United States Environmental Protection Agency; D014876:Water Pollution / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply / Q000032:analysis
D002273:Carcinogens; D012997:Solvents