Pulsatile versus continuous oxytocin infusion for the oxytocin challenge test.
In a prospective study, 140 patients had an oxytocin challenge test with either a continuous or a pulsed infusion (one minute of infusion in every five minutes). Both infusion regimens had similar success rates in terms of uterine contractions (97.1 vs 98.6%). The potency ratio (pulsed versus continuous infusion) was significant at 2.7 (1.27 to 5.2), which means that more uterine activity was induced with each mU of oxytocin with pulsatile than with continuous administration. The total amount of oxytocin required to obtain three good contractions in 10 minutes was about 40% less with pulsed administration than with continuous infusion, but the test took 40 minutes longer with the pulsed than with the continuous infusion (P < 0.01).
Servicio de Obstetricia, Hospital Maternal La Fe, Universitat de Valencia, Spain.
A J
AJ
Perales
V J
VJ
Diago
J
J
Monleón-Sancho
R
R
Grifol
R
R
Dominguez
J A
JA
Minguez
J
J
Monleón
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D010121:Oxytocin / Q000008:administration & dosage; D011247:Pregnancy; D011673:Pulsatile Flow; D014590:Uterine Contraction / Q000187:drug effects*
D010121:Oxytocin