Increased cAMP levels in human hair follicles due to local treatment with trichoriboside.
Local therapy with trichoriboside and trichosaccharide, which have been found to be beneficial for scalp hair maintenance in adult males affected by androgenic alopecia, was found to increase cAMP levels in human scalp hair follicles. The increase was significant in men affected by androgenic alopecia, whereas it was not significant in unaffected control men. Trichoriboside showed a greater activity than trichosaccharide, and such activity was accompanied by a significant concomitant reduction of ATP in the hair.
Gazzani
G
G
Crinos s.p.a., Villa Guardia, Como, Italy.
Roncoroni
S
S
Corsi
M
M
Falchi
M
M
Ferrero
M E
ME
D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000287:Administration, Topical; D000328:Adult; D000505:Alopecia / Q000188:drug therapy; D000242:Cyclic AMP / Q000032:analysis* / Q000378:metabolism; D006197:Hair / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011089:Polydeoxyribonucleotides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D011089:Polydeoxyribonucleotides; D011134:Polysaccharides; C090245:trichoriboside; C090244:trichosaccharide; D000255:Adenosine Triphosphate; D000242:Cyclic AMP