[Intracellular interactions in the hematopoietic system after massive radiation exposure].
The review article deals with acute radiation damage to the bone marrow spatial structure, disturbances of cell-cell interactions, and stromal cytokine(s) production, hence representing limiting factors for effective postradiation recovery of blood system. The evidence for radiation-induced stromal functional activation is discussed, along with opportunity of local growth factors deficiency, thus requiring a replacement therapy with exogenous cytokines.
Chukhlovin
A B
AB
Mikhaĭlova
N B
NB
Afanas'ev
B V
BV
D000818:Animals; D002450:Cell Communication / Q000528:radiation effects*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006413:Hematopoietic System / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology
Mezhkletochnye vzaimodeĭstviia v sisteme gemopoéza posle massivnogo radiatsionnogo vozdeĭstviia.