[Rhinocerebral mucormycosis in type 2 diabetes mellitus. Description of a clinical case with favorable outcome].
The case is reported of a 70-year-old man with decompensated non-acidotic type-2 diabetes mellitus and with rhinocerebral mucormycosis, manifested by inflammatory infiltration of the left nasal, paranasal, maxillary, and orbital bone structures with left ophthalmoplegia. The patient was cured after amphotericin B treatment (total dose 2.7 g) and 30 sessions of hyperbaric oxygen (2.8 atmospheres). Cure was confirmed by follow-up over more than 2 years. It is concluded that rhinocerebral mucormycosis must be treated, in addition to control of predisposing factors, and especially by restoring endocrine-metabolic balance, by adequate surgical revision, with specific high-dose amphotericin B treatment and adjunctive hyperbaric oxygen. Further studies are desirable in order to define the advantages of these therapeutic measures.
Agostino
A
A
Divisione II Medicina Interna, USL RM/3, Ospedale S. Pertini di Roma.
Parenzi
A
A
D'Amore
F
F
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D009668:Nose Diseases / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000666:Amphotericin B
Mucormicosi rinocerebrale in corso di diabete mellito tipo 2. Descrizione di un caso clinico a decorso favorevole.