Detection of multiple thromboembolism in congenital antithrombin III deficiency with indium-111-platelet scintigraphy.
Congenital deficiency of antithrombin III (AT III), a physiological inhibitor of blood coagulation, may lead to increased thromboembolism. Here, we report a case of multiple thromboembolism associated with congenital AT III deficiency. The diagnosis of systemic thromboembolism was made by 111In-labeled platelet scintigraphy (In-scan) which allowed for the daily assessment of thromboemboli size. Thromboemboli were found not only in sites predicted clinically, but also in unexpected sites. In these patients, thus, a careful whole-body examination is necessary for full detection of thromboemboli. In-scan may be a useful technique for such screening.
First Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
K
K
Kawasugi
K
K
Gohchi
Y
Y
Kuniyasu
J
J
Matsuda
T
T
Kinoshita
D000293:Adolescent; D020152:Antithrombin III Deficiency; D001792:Blood Platelets; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000209:etiology; D011859:Radiography; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013924:Thrombophlebitis / Q000000981:diagnostic imaging* / Q000209:etiology
D007205:Indium Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin