Signal transduction. Switching off MAP kinases.
Protein phosphatases have recently been identified that inactivate MAP kinases and turn off intracellular signalling pathways. Their regulation may determine the response of cells to stimuli that signal via MAP kinases.
Clarke
P R
PR
European Molecular Biology Laboratory, Heidelberg, Germany.
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D016384:Consensus Sequence; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases; D008954:Models, Biological; D008969:Molecular Sequence Data; D016716:PC12 Cells; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*; D013379:Substrate Specificity
D005656:Fungal Proteins; D017978:Receptors, Growth Factor; D011494:Protein Kinases; D020794:Receptor Protein-Tyrosine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; D010749:Phosphoprotein Phosphatases