Regression of cardiac hypertrophy and myosin isoenzyme patterns by losartan and captopril in renovascular hypertensive rats.
To test the effect of losartan and captopril on cardiac hypertrophy and myosin isoenzyme, two-kidney, one-clip (2K 1C) renovascular hypertensive rats (RHR) were used. Eight weeks after the onset of hypertension, losartan 5 mg.kg-1.d-1 and captopril 50 mg.kg-1.d-1 were administered p.o. to 2 groups of RHR, respectively for 8 wk. The results showed that captopril significantly decreased the cardiac mass (607 +/- 169 mg vs 1029 +/- 132 mg) and total protein content (120 +/- 38 mg vs 198 +/- 31 mg), concomitant with significant decrease of arterial blood pressure (BP) (15.4 +/- 5.2 kPa vs 28.5 +/- 4.9 kPa). Losartan also induced a significant decrease in cardiac mass (671 +/- 116 mg vs 1029 +/- 132 mg) and protein content (142 +/- 29 mg vs 198 +/- 31 mg), as well as significantly lowered the BP (15.2 +/- 2.1 kPa vs 28.5 +/- 4.9 kPa). It is important to be note that both drugs normalized the shift of myosin isoenzyme in RHR. These results indicated that both drugs, having potent antihypertensive effects, can effectively reverse the cardiac hypertrophy and abnormal distribution of myosin isoenzyme patterns.
Research Section of Pharmacology, Hu'nan Medical University, Changsha, China.
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D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy*; D007093:Imidazoles / Q000494:pharmacology*; D019808:Losartan; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology*
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D007093:Imidazoles; D013777:Tetrazoles; D002216:Captopril; D009218:Myosins; D019808:Losartan