[Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage].
The efficiency of interferon inductor, kagocel, in hemopoiesis and immunity disturbances caused by sublethal doses of ionizing radiation was investigated. The experiments showed that irradiation of mice with a dose of 0.9 Gy causes short-term drop of a number of cells in the bone marrow and lymphoid organs, reducing of CFUs and CFU-GM levels, decrease in a number of antibody-formation cells in spleen and falling of reaction of blast-transformation of lymphocytes. The injection of kagocel 1 and 5 days after irradiation enhanced post-irradiation recovery of bone marrow hematopoiesis, stimulated compensatory potential of hematopoietic system and increase in antiviral resistance of irradiated animals.
Lebedev
V G
VG
Tazulakhova
E B
EB
Moroz
B B
BB
Deshevoĭ
Iu B
IuB
Parshina
O V
OV
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006072:Gossypol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D007107:Immune System / Q000187:drug effects* / Q000528:radiation effects; D009980:Influenza A virus / Q000276:immunology; D007369:Interferon Inducers / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000276:immunology; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000150:complications / Q000276:immunology / Q000628:therapy*
D007369:Interferon Inducers; C056991:cagocel-1; D006072:Gossypol
Vliianie kagotsela na postradiatsionnoe vosstanovlenie krovetvoreniia i immunnogo statusa u mysheĭ pri deĭstvii ioniziruiushcheĭ radiatsii v subletal'noĭ doze.