Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.
In the present study, the electrophysiologic properties of ATP-sensitive potassium channels were evaluated in an intestinal, cholecystokinin-secreting cell line (STC-1). Channels were operative under basal conditions and, in cell-attached membrane patches, channel activity was decreased by glucose or disopyramide, agents which classically inhibit ATP-sensitive potassium channels. Channel activity was increased by the KATP channel opener, diazoxide. Intestinal ATP-sensitive potassium channels appear to behave in a similar manner to those found in cardiac and pancreatic beta cells.
Basavappa
S
S
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Liddle
R A
RA
Mangel
A W
AW
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D002478:Cells, Cultured; D002766:Cholecystokinin / Q000378:metabolism*; D004206:Disopyramide / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism*; D008564:Membrane Potentials; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology
D015221:Potassium Channels; D000255:Adenosine Triphosphate; D002766:Cholecystokinin; D004206:Disopyramide