Two cases of proton MR spectroscopy of the brain after irradiation.
Proton magnetic resonance spectroscopy (1H-MRS) is thought to be more sensitive to radiation damage of the brain than magnetic resonance imaging (MRI). We presented performed 1H-MRS using the stimulated echo acquisition method (STEAM) for non-tumor sites in 2 patients who received radiation therapy for their brain tumors. In the first case up to 45 days after radiation, we could observe a normal spectra presented three major peaks of N-acetyl aspartate (NAA), creatine and phosphocreatine (Cr), and choline (Cho). In the second case who had radiation necrosis 1 year after radiation, the spectra showed a decrease in the all peaks beneath the noise level.
Nakakoshi
T
T
Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan.
Matsuzawa
H
H
Houkin
K
K
Miyasaka
K
K
Arimoto
T
T
D000368:Aged; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000532:radiotherapy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged