Regulation of maternal insulin-like growth factor I by placental growth hormone in pregnancy. Possible action of maternal IGF-I on fetal growth.
In normal and in pathological human pregnancies, a specific placental growth hormone variant, rather than placental lactogen, substitutes for the suppressed pituitary GH to stimulate the maternal insulin-like growth factor I (IGF-I). In pathological pregnancies with disorders of the feto-placental unit, low levels of placental GH hormone result in relatively low levels of maternal IGF-I. In normal pregnancies, the baby birth weight is positively correlated with maternal IGF-I values.
Caufriez
A
A
Department of Obstetrics and Gynaecology, Université Libre de Bruxelles, Belgium.
Frankenne
F
F
Hennen
G
G
Copinschi
G
G
D001724:Birth Weight; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism* / Q000502:physiology; D010926:Placental Hormones / Q000502:physiology*; D011247:Pregnancy / Q000378:metabolism*
D010926:Placental Hormones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone