Investigation of the anti-inflammatory effects of Paederia foetida.
A detailed investigation on the anti-inflammatory activity of the butanol fraction of a methanol extract (BMEL) of the defatted leaves of Paederia foetida was undertaken to find the pharmacological basis for the ethnomedical use of the plant. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. It decreased liver aspartate transaminase activity without affecting serum aspartate transaminase activity. It did not, however, affect adrenal weight and ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. BMEL antagonised hyposaline-induced haemolysis of human red blood cells and an elevation of rat serum acid phosphatase activity, indicating the presence of a membrane stabilising activity. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. The results indicate that there is some rationale behind the ethnomedical use of the plant for treating inflammatory disorders.
Institute of Post Graduate Teaching and Research, Gujarat Ayurved University, India.
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Bhavsar
D020001:1-Butanol; D000135:Acid Phosphatase / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D000440:Butanols / Q000737:chemistry; D005591:Chemical Fractionation; D004195:Disease Models, Animal; D004910:Erythrocyte Membrane / Q000187:drug effects; D005260:Female; D006099:Granuloma / Q000517:prevention & control*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008519:Medicine, Traditional; D000432:Methanol / Q000737:chemistry; D009929:Organ Size / Q000187:drug effects; D009961:Orosomucoid / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013154:Spleen / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001798:Blood Proteins; D000440:Butanols; D009961:Orosomucoid; D010936:Plant Extracts; D020001:1-Butanol; D001219:Aspartate Aminotransferases; D000135:Acid Phosphatase; D001205:Ascorbic Acid; D000432:Methanol