[Effect of mannitol on human retinal blood flow].
The effect of hyperosmotic agents (20% mannitol) on the retinal circulation was evaluated in 14 eyes of 7 normal subjects. Laser speckle retinal blood flow velocimetry with simultaneous real-time measurement of retinal vessel diameter was used. Experiments were performed in a double-masked crossover design and each subject was given either 20% mannitol or physiological saline solution by intravenous drip. The retinal blood flow rate was measured just before the administration of the agents and after the intravenous drips. After the 20% mannitol administration, intraocular pressure was reduced and ocular perfusion pressure, retinal blood flow velocity, and retinal blood flow rate increased significantly (paired t-test, p < 0.01). There was not statistically significant difference between the retinal blood flow rate before and after the administration of physiological saline solution (p > 0.05), but the retinal blood flow velocity increased significantly (p < 0.05). The ratio between the retinal blood flow rate before and after the administration of 20% mannitol was statistically larger than that of physiological saline solution (p < 0.05).
Suzuki
Y
Y
Department of Ophthalmology, Aoyama Hospital, Japan.
Yoshisuji
M
M
D001783:Blood Flow Velocity / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012171:Retinal Vessels / Q000187:drug effects* / Q000502:physiology
D008353:Mannitol