CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders.
To assess the diagnostic value of measuring CA-125 levels in peritoneal fluid from women with nonmalignant gynecologic disorders, we determined CA-125 levels in peritoneal fluid and in serum collected simultaneously from 46 women undergoing gynecologic surgery. Patients with benign ovarian disease, non-ovarian gynecologic pathology and severe endometriosis had, on average, higher CA-125 levels in peritoneal fluid than did patients with a normal pelvis and those with mild endometriosis. There was no obvious correlation between peritoneal fluid and serum levels of CA-125. Our data show that (1) measurement of serum CA-125 levels is not useful for distinguishing between different benign gynecologic disorders, and (2) levels of CA-125 in peritoneal fluid in benign gynecologic disorders are comparable to the reported lower range of levels observed in women with intraperitoneal malignancies.
Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637.
M A
MA
Ismail
J
J
Rotmensch
L J
LJ
Mercer
B S
BS
Block
G I
GI
Salti
J A
JA
Holt
D000359:Aftercare; D001202:Ascitic Fluid / Q000737:chemistry*; D018394:CA-125 Antigen / Q000032:analysis*; D015986:Confounding Factors, Epidemiologic; D003937:Diagnosis, Differential; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D012680:Sensitivity and Specificity
D018394:CA-125 Antigen