[A trial of using Cefobid (cefoperazone) in treating infections of the skin and soft tissues].
A clinical laboratory investigation of cefoperazon in the treatment of 27 patients with burn traumata and purulent necrotic wounds of the soft tissues of various genesis and localization was carried out. The clinical efficacy of the treatment was 75-86.6 per cent. 4 patients with extended purulent wounds of the soft tissues and bone affections were treated with cefoperazon and local application of gentacicol (a dosage form of gentamicin based on collagen with prolonged action) which provided the clinical effect in all the cases. 226 isolates from the wounds, urine, blood, sputum, pleural fluid and other substrates were tested and a rather high activity of cefoperazon against many strains of gram-positive and gram-negative organisms including Staphylococcus spp., Pseudomonas aeruginosa, Escherichia coli, Providencia sp. and Proteus spp. was revealed. The tolerance of the drug in all the cases was good.
Iakovlev
V P
VP
Blatun
L A
LA
Krutikov
M G
MG
Puchkova
L S
LS
Elagina
L V
LV
Izotova
G N
GN
D000293:Adolescent; D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D002056:Burns / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D002438:Cefoperazone / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D018461:Soft Tissue Infections / Q000188:drug therapy* / Q000382:microbiology; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
D002438:Cefoperazone
Opyt primeneniia tsefobida (tsefoperazona) pri lechenii infektsiĭ kozhi i miagkikh tkaneĭ.