Activity of anthraquinonic and naphthoquinonic compounds on oral bacteria.
The activity of anthraquinonic compounds and naphthoquinones was tested by micromethods against oral bacteria. The more significant results were obtained with naphthoquinones. Plumbagin, juglone and lawsone possess a wide spectrum of activity. The lowest MIC values were observed with plumbagin and the combination of juglone and lawsone results in a synergism against cariogenic bacteria. Among the eight anthraquinonic compounds investigated only rhein showed significant antimicrobial properties. Results obtained could suggest the use of rhein and plumbagin alone or juglone and lawsone combined for treatment of oral infectious diseases.
Laboratoire de Pharmacognosie, Faculté des Sciences pharmaceutiques et biologiques, Lille, France.
N
N
Didry
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L
Dubreuil
M
M
Pinkas
D000880:Anthraquinones / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D003470:Culture Media; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000187:drug effects / Q000382:microbiology*; D009285:Naphthoquinones / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects
D000880:Anthraquinones; D003470:Culture Media; D009285:Naphthoquinones