A possible neural mechanism underlying consciousness based on the pattern processing capabilities of pyramidal neurons in the cerebral cortex.
This paper examines a possible neural mechanism underlying the phenomenon of consciousness by exploring the ability of cortical pyramidal cells to process patterns of information. A numerical model of a section of a neuron is described that enables the transient membrane potential distribution to be predicted following inputs to the cell. The neuron model incorporates learning by modelling the ability of dendritic spine receptors to undergo changes in their sensitivity if they receive inputs when their local membrane is depolarized. Simulations show the cell to be capable of recognizing patterns amongst its inputs, and to be able to extend its repertoire of learnt patterns by associating one pattern of inputs with another. These pattern processing capabilities can take place within the apical dendritic tree, whilst the soma sees a much attenuated and slower response that reflects the general level of pattern recognition taking place in the dendrites. It is argued here that the distribution of patterns stored in the apical dendrites of all the pyramidal cells represents the cortical knowledge base. Incoming patterns of information are compared with those stored in the cortical knowledge base to pick out components that have been experienced before. The resulting distribution of soma responses represents the way the incoming patterns of information are perceived. Most of the patterns learnt arise from other pyramidals and represent information about cortical behaviour itself. The distribution of soma responses therefore represents a perception of the self as well as a perception of the environment. It is argued here that this intimate perception of the self could underlie the phenomenon of consciousness.
Bath Institute of Medical Engineering, Wolfson Centre, Royal United Hospital, Bath, U.K.
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Orpwood
D002540:Cerebral Cortex / Q000166:cytology; D003198:Computer Simulation; D003243:Consciousness / Q000502:physiology*; D003712:Dendrites / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D008960:Models, Psychological; D011603:Psychophysiology; D017966:Pyramidal Cells / Q000502:physiology*