Bladder outlet obstruction after multiple periurethral polytetrafluoroethylene injections.
Periurethral polytetrafluoroethylene (Teflon) injections have been reported to be successful for the treatment of urinary incontinence after transurethral resection or radical prostatectomy. However, the use of polytetrafluoroethylene is controversial due to reports of distant migration and granulomatous reaction after periurethral injection. We report on a patient with a history of periurethral polytetrafluoroethylene injection for postoperative stress incontinence in whom bladder outlet obstruction developed and who underwent repeat transurethral resection 9 years later. Pathological examination revealed that the material responsible for the obstruction was almost totally composed of a foreign body giant cell response to the polytetrafluoroethylene implant ("teflonoma").
Department of Anatomic Pathology, University of Virginia Health Sciences Center, Charlottesville.
C D
CD
McKinney
M J
MJ
Gaffey
J Y
JY
Gillenwater
D000368:Aged; D000369:Aged, 80 and over; D005549:Foreign-Body Reaction / Q000209:etiology; D006801:Humans; D007267:Injections; D008297:Male; D011138:Polytetrafluoroethylene / Q000008:administration & dosage / Q000009:adverse effects*; D014521:Urethra; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology*; D014550:Urinary Incontinence, Stress / Q000628:therapy
D011138:Polytetrafluoroethylene