CT and MRI of Gorham syndrome.
Gorham syndrome, also known as massive osteolysis or vanishing bone, is a rare disorder (135 cases reported) leading to extensive loss of bony matrix, replaced by proliferating thin-walled vascular channels. Three histologically proven cases of the disease are reported, including the clinical presentation and modern imaging features with CT (with 3D reconstruction) as well as T1- and T2-weighted MRI. Two cases in young women were located in the pelvis with extensive osteolysis reaching to the acetabulum. The third case in a 2-month-old boy is the youngest case ever reported and involved the humerus. The radiological appearance of the disease is discussed and the importance of the modern imaging methods debated.
Radiologische Universitätsklinik Freiburg, Abteilung Röntgendiagnostik, Germany.
P
P
Vinée
M O
MO
Tanyü
K H
KH
Hauenstein
G
G
Sigmund
B
B
Stöver
C P
CP
Adler
D000077:Acetabulum / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging* / Q000473:pathology*; D007223:Infant; D007512:Ischium / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010015:Osteolysis, Essential / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D010384:Pelvic Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D011630:Pubic Bone / Q000000981:diagnostic imaging / Q000473:pathology; D011856:Radiographic Image Enhancement; D012784:Shoulder Fractures / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods