[The depressor effect of intracerebroventricular injection of BQ123 and endothelin (ET)--antiserum on hypertensive rats produced by aorta stenosis and hypersaline uptake].
An experimental model of hypertensive rat was made by abdominal aorta stenosis and hypersaline uptake. The blood pressure was significantly decreased by intracerebroventricular injection (i.c.v.) of BQ123 a potent antagonist of ET-1 receptor, in a dose-dependent manner. Negative chronotropic effect on the heart was produced by high dose of BQ123, while the depressor effect was produced by i.c.v. ET-antiserum. These results indicate that endothelin in CNS may play an important role in the pathological physiology of hypertension.
Ma
X F
XF
Department of Physiology, Beijing Medical University.
Qiu
X C
XC
Tang
C S
CS
D000818:Animals; D001012:Aorta, Abdominal; D001794:Blood Pressure / Q000187:drug effects*; D003250:Constriction; D016232:Endothelins / Q000276:immunology / Q000494:pharmacology*; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007106:Immune Sera / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride
D016232:Endothelins; D007106:Immune Sera; D010456:Peptides, Cyclic; D012965:Sodium Chloride; C072247:cyclo(Trp-Asp-Pro-Val-Leu)