[Ticlopidine and aspirin in the treatment of unstable angina: comparative evaluation of their effect of anti-aggregation and platelet membranes].
The study was undertaken to examine changes in ADP-induced aggregation of platelets, blood-circulating platelet aggregates, platelet phospholipids and cholesterol in patients with unstable angina depending on the therapy with disaggregatory agents. The patients from Group 1 (n = 23) received ticlopidine, 500 mg/day, in addition to antianginal therapy and heparin; those from Group 2 (n = 21) had aspirin, 320 mg/day, those from Group 3 (n = 36) took no disaggregahts. Ticlopidine was found to produce more marked effects on ADT-induced plasma platelet aggregation, in vivo reversible platelet aggregation, and reduced platelet levels of free cholesterol, as compared to aspirin.
Shalaev
S V
SV
Mezhetskaia
I A
IA
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010980:Platelet Membrane Glycoproteins / Q000187:drug effects; D012189:Retrospective Studies; D013988:Ticlopidine / Q000494:pharmacology / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D010743:Phospholipids; D010980:Platelet Membrane Glycoproteins; D006493:Heparin; D002784:Cholesterol; D013988:Ticlopidine; D001241:Aspirin
Tiklopidin i aspirin pri nestabilńoĭ stenokardii: sravnenie dezagregiruiushchikh svoĭstv i vozdeĭstviia na membrany trombotsitov.