Importance of the coronary collateral circulation for the distribution of anterograde and retrograde delivered cardioplegic solution in aortocoronary bypass surgery: a haemodynamic study.
The importance of coronary collateral circulation for homogeneous distribution of anterograde and retrograde delivery of cardioplegia was evaluated in 36 patients undergoing myocardial revascularization. All patients had three-vessel coronary artery disease, with a stenosis of the right coronary artery of at least 80%. The patients were randomized into two groups: group A (n = 19) received anterograde delivered cardioplegic solution and group B (n = 17) received retrograde. Both groups were further subdivided depending on the pathology of the right coronary artery, as evaluated on preoperative coronary angiography. In group A1 (n = 8) and group B1 (n = 7) there was no visualization of collateral circulation from the left to the right coronary artery system, whereas in group A2 (n = 11) and group B2 (n = 10) there was retrograde filling of the right coronary artery by collateral circulation. Right atrial pressure increased significantly (P < 0.05) in group A1 and was elevated in group A2, but not significantly (P = 0.07). By contrast, right arterial pressure decreased in groups B1 and B2. Analysis of the individual differences in the right atrial filling pressure showed a statistical significance between the two subgroups (group B1-1.0(0.5) versus group B2-1.8(1.1), P < 0.05), although the individual decrease of the right ventricular stroke work index was not significant. It is concluded that collateral circulation is important for an adequate distribution of anterogradely delivered cardioplegia and is also beneficial in cases of retrograde delivery.
Department of Thoracic and Cardiac Surgery, University Hospital Nijmegen St Radboud, The Netherlands.
L
L
Noyez
J A
JA
van Son
T
T
van der Werf
J T
JT
Knape
J
J
Gimbrère
W N
WN
van Asten
L K
LK
Lacquet
W
W
Flameng
D000328:Adult; D000368:Aged; D002314:Cardioplegic Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003097:Collateral Circulation / Q000502:physiology; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged
D002314:Cardioplegic Solutions