Oncogene amplifications in early-stage human prostate carcinomas.
Oncogene amplifications are frequently found in solid tumours and are often associated with more aggressively growing forms of human cancer. The proto-oncogenes c-myc, c-erbB2/neu and the 11q13 band are the most frequently amplified regions in adenocarcinomas of various origins. The present study was undertaken to define whether c-myc, int2/FGF3 (11q13 region) and c-erbB2/neu genes are involved in prostate tumorigenesis. Tumours and peripheral lymphocyte DNA from 21 localized early-stage prostatic carcinomas were analysed by Southern-blot electrophoresis for amplification of the c-myc and c-erbB2/neu genes and the 11q13 region (int2/FGF3). We detected no amplification of these 3 oncogenes in our panel.
Laboratoire d'Oncogénétique, Centre René Huguenin, St-Cloud, France.
A
A
Latil
J C
JC
Baron
O
O
Cussenot
G
G
Fournier
L
L
Boccon-Gibod
A
A
Le Duc
R
R
Lidereau
D014408:Biomarkers, Tumor / Q000235:genetics; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000032:analysis; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D018734:Genes, erbB-2 / Q000235:genetics; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D009857:Oncogenes / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C496444:FGF3 protein, human; D051518:Fibroblast Growth Factor 3; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors