[Activity of sodium-potassium adenosinetriphosphatase and cotransport of sodium, potassium and chloride ions in patients with bronchial asthma and chronic obstructive pulmonary diseases].
Diminished activities of Na/K/ATPase and Na/K/2Cl-cotransport in arterial smooth muscles lead to vasoconstriction. We found it interesting to check if a decrease in activities of those ion transports are present in other diseases with smooth muscles hyperreactivity; bronchial asthma and COPD. The study was performed on lymphocytes collected from 57 patients with atopic asthma, nonatopic asthma and COPD; the groups consisted of 18, 28 and 11 patients respectively. Control group was composed of 15 healthy subjects. There were no significant differences in Na/K/-ATPase and Na/K/2Cl-cotransport activities either in the exacerbation compared to the remission in the examined group, or in patients versus controls. Na/K-ATPase activity was strongly dependent on pO2.
Katedry i Kliniki Chorób Wewnetrznych i Alergologii, Akademii Medycznej, Wrocławiu.
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W
Barg
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Małolepszy
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000378:metabolism*; D001693:Biological Transport, Active; D002712:Chlorides / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D002712:Chlorides; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D010100:Oxygen
Aktywność adenozynotrójfosfatazy sodowo-potasowej i współtransportu jonów sodu, potasu i chloru u chorych na astme oskrzelowa i przewlekła obturacyjna chorobe płuc.