[Adjusted survival of the graft in renal transplantation. Multivariate analysis of prognostic factors].
Three hundred and seven first corpse transplantations performed in the Clínica Universitaria of Navarra since 1976 are analyzed. The cases are divided in two series, Current and Historic, depending on whether the immunosuppressive protocol included cyclosporin A. First, actual survival curves from both series were compared, obtaining a significantly improved survival in the cyclosporin A series (p). Then, the most influential prognostic features in each series are analyzed for the various post-transplantation periods. With regard to adjusted graft survival in the Historic Series, both initial function and the number of rejections have influence during the first post-transplantation year. HLA A + B identities and the donor's age influence during the immediate one-to-three months period. In the Current Series, time of cold ischaemia and number of rejections act during the earliest (first month) and the latest (between one to three years) periods. The donor's cause of death and the recipient's age influence during the first month of evolution. The initial function and the presence of surgical complications influence between the first month and the first year.
Departamento de Urología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
L
L
Aguera
J E
JE
Robles
D
D
Rosell
F I
FI
Rodríguez Rubio
J I
JI
Abad
J J
JJ
Zudaire
P
P
Errasti
J M
JM
Berian
D000206:Actuarial Analysis; D016572:Cyclosporine / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D015996:Survival Rate
D016572:Cyclosporine
Supervivencia ajustada del injerto en el trasplante renal. Analisis multivariado de los factores pronóstico.