The human growth-arrest-specific gene GAS1 maps outside the candidate region of the gene for nevoid basal cell carcinoma syndrome.
The human growth-arrest specific gene GAS1 maps to chromosome bands 9q21.3-->q22, the region known to contain the tumour suppressor gene responsible for nevoid basal cell carcinoma syndrome (NBCCS). Because of its putative action as a tumour suppressor gene, the GAS1 gene was analysed as a candidate for the NBCCS gene. Using two-colour fluorescence in situ hybridization, the GAS1 gene maps outside the interval which, by genetic analysis, has been shown to contain the NBCCS gene.
Centre for Molecular Biology and Biotechnology, University of Queensland, Australia.
C
C
Wicking
M
M
Breen
K
K
Negus
J
J
Berkman
A
A
Evdokiou
P
P
Cowled
G
G
Chenevix-Trench
B
B
Wainwright
D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics*; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D003360:Cosmids; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000166:cytology; D005810:Multigene Family; D012097:Repressor Proteins / Q000235:genetics*
D012097:Repressor Proteins