Relation between exposure to fluoride and bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms.
BACKGROUND
The relation between plasma fluoride levels and bronchial responsiveness was investigated in a longitudinal study in aluminium potroom workers who reported work-related asthmatic symptoms.


METHODS
From a cross-sectional respiratory survey, 26 men who reported work-related asthmatic symptoms on a validated questionnaire were selected for repeated measurements of bronchial responsiveness to methacholine. Regular analyses of plasma fluoride levels were performed. Exposure to fluoride and total particulates was assessed from routine surveillance of the workplace. Bronchial responsiveness was expressed as the dose-response slope of the line through the origin and last data point.


RESULTS
A positive association was found between bronchial responsiveness and plasma fluoride levels, such that an increase in the plasma fluoride level of 10 ng/ml was associated with an increase in the dose-response slope by a factor of 1.11 (95% confidence interval 1.05 to 1.17). Plasma fluoride levels were associated with the total atmospheric fluoride concentration in mg/m3 (beta = 28.1), but not with total particulates in the environment.


CONCLUSIONS
Bronchial responsiveness in aluminium potroom workers reporting work-related asthmatic symptoms appears to be related to plasma levels of fluoride. The underlying mechanism is, however, unknown.
Hydro Aluminium, Health Department, Ardal Aluminium Plant, Norway.
V
V
Søyseth
J
J
Kongerud
J
J
Ekstrand
J
J
Boe
D000328:Adult; D000535:Aluminum / Q000009:adverse effects*; D001249:Asthma / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D005459:Fluorides / Q000097:blood*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology
D000535:Aluminum; D005459:Fluorides