Phosphatidylserine suppresses myelin-induced experimental allergic neuritis (EAN) in Lewis rats.
Phosphatidylserine administered as an aqueous dispersion to myelin-induced experimental allergic neuritis rats had a significant effect on disease course. Intraperitoneal injections of 30 mg/kg were given daily beginning at the onset of disease and continued for 14 days. Clinical severity and mortality were markedly reduced by this treatment as compared to saline controls. Improved clinical outcome was associated with a reduction in peripheral nerve pathology. A possible mechanism involving tumor necrosis factor is discussed.
Department of Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103.
Y
Y
Maeda
R
R
Maeda
J W
JW
Prineas
R W
RW
Ledeen
D000818:Animals; D008297:Male; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D010718:Phosphatidylserines / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew
D010718:Phosphatidylserines