Psychotropic drugs in pregnancy and lactation.
OBJECTIVE
This article reviews the literature on the use of psychotropic drugs in pregnancy and lactation.


METHODS
Medline search yielded more than five hundred titles. Articles were reviewed and ninety-one were selected for reference.


RESULTS
Fetal physiology and teratogenicity are discussed and the effects of specific drugs on the fetus and newborn are presented. When possible, recommendations for use or non-use are presented.


CONCLUSIONS
Though no controlled studies have ever been done in pregnant women to truly prove their safety, it appears that most, but not all, current psychotropic drugs appear fairly safe for use in pregnancy.
Kauai Community Mental Health Center, University of Hawaii.
H L
HL
Goldberg
D003024:Clozapine / Q000627:therapeutic use; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D007774:Lactation / Q000187:drug effects; D008094:Lithium / Q000627:therapeutic use; D001523:Mental Disorders / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D011644:Puerperal Disorders / Q000188:drug therapy*
D011619:Psychotropic Drugs; D005473:Fluoxetine; D008094:Lithium; D003024:Clozapine