Immunodeficiency viruses. Not enough sans Nef.
The nef genes of HIV and SIV are dispensable in vitro, but are essential for viral spread and disease progression in vivo. Nef-induced down-regulation of CD4, the viral receptor, may be the key to this requirement.
Littman
D R
DR
Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143-0414.
D000818:Animals; D015704:CD4 Antigens / Q000096:biosynthesis* / Q000235:genetics; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000382:microbiology; D002478:Cells, Cultured; D015536:Down-Regulation; D015693:Gene Products, nef / Q000235:genetics / Q000502:physiology*; D015754:Genes, nef; D006678:HIV / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D000882:Haplorhini; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D014779:Virus Replication / Q000235:genetics; D054311:nef Gene Products, Human Immunodeficiency Virus
D015704:CD4 Antigens; D015693:Gene Products, nef; D011518:Proto-Oncogene Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)