Radiation induced sarcomas following treatment for breast cancer: presentation of a series of 14 cases treated with an aggressive surgical approach.
According to the criteria established by Cahan et al., we report 14 radiation induced sarcomas occurring in the treated volume after radiation therapy for adenocarcinoma of the breast. All these sarcomas were treated by wide surgical resection. In spite of a macroscopic free margin, only patients who underwent major amputation could hope to be cured. All the centrally located sarcomas recurred.
Bobin
J Y
JY
Department of Surgical Oncology, Centre Léon Bérard, Lyon, France.
Rivoire
M
M
Delay
E
E
el Arini
A
A
Mignotte
H
H
Wagner
P
P
Zlatoff
P
P
D000230:Adenocarcinoma / Q000532:radiotherapy*; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D018567:Breast Neoplasms, Male / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012509:Sarcoma / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome