Specificity in splicing.
Considerable information about the process of pre-mRNA splicing has accumulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression, including alternative splicing, could be controlled by the transcription of specific splicer RNA genes. We re-assess our model here, in the light of subsequent developments.
Holliday
R
R
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, North Ryde, NSW, Australia.
Murray
V
V
D017398:Alternative Splicing; D000818:Animals; D005091:Exons; D005796:Genes; D006801:Humans; D007438:Introns; D008957:Models, Genetic; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing
D012322:RNA Precursors