Decreased T cell reactivity to trypsinized group A, type M22 streptococci in psoriasis.
The proliferative responses of peripheral blood mononuclear cells from patients with guttate and chronic plaque psoriasis to streptococcal M protein were investigated using whole and trypsinized group A M22-positive streptococci. Peripheral blood mononuclear cell responses to whole type M22 group A streptococci were significantly increased in guttate, but not chronic plaque, psoriasis patients compared to 17 non-psoriatic controls (p < 0.05; n = 17). A significant reduction of this response was observed in both guttate (p < 0.001; n = 17) and chronic plaque (p < 0.01; n = 27) psoriatic patients, but not in the control group, after repeated trypsinization to remove M protein from the streptococci. Furthermore, the difference between the peripheral blood mononuclear cell response to untrypsinized and trypsinized streptococci was significantly greater in the guttate patients than in the controls (p < 0.02). This preliminary study has shown an increased reactivity of T lymphocytes with specificity for trypsin-sensitive protein expressed by type M22 streptococci in the peripheral blood of patients with psoriasis.
Department of Dermatology, St Mary's Hospital, London, UK.
B S
BS
Baker
S
S
Bokth
J J
JJ
Garioch
A V
AV
Powles
H
H
Lewis
H
H
Valdimarsson
L
L
Fry
D000293:Adolescent; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000494:pharmacology*; D002352:Carrier Proteins; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013297:Streptococcus pyogenes / Q000502:physiology*; D014357:Trypsin
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein; D014357:Trypsin