[Tegalid distribution in the body of rats].
Pharmacokinetic studies of a new anthelminthic tegalid, made in this country, were carried out. The drug concentrations in biologic material were measured by high-pressure liquid chromatography. The drug was found to circulate for a rather long time in the blood, virtually not accumulating in any of the examined organs, except the liver. Tegalid pharmacokinetics can be fairly well approximated by a unicompartmental model with due consideration for its absorption.
Lopatina
N B
NB
Rodionov
A P
AP
Lebedeva
M N
MN
Mikhaĭlitsyn
F S
FS
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D001549:Benzamides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D008297:Male; D051381:Rats; D012044:Regression Analysis; D013997:Time Factors; D014018:Tissue Distribution
D000871:Anthelmintics; D001549:Benzamides; C048082:tegalide
Issledovanie raspredeleniia tegalida v organizme krys.