[Pharmacokinetics of matrine in healthy volunteers].
A sensitive high performance liquid chromatographic analytical method was established for determining the concentration of matrine in human serum. The recovery of matrine was 99.1-102.2%. The RSD (%) in within-day and between-days were no more than 6%. The calibration curve was linear in the range from 1.25 micrograms.ml-1 to 40.0 micrograms.ml-1 with r = 0.9997. The serum drug concentration-time curve after iv infusion with a dose of 6 mg.kg-1 in 100 ml glucose solution for 8 healthy volunteers was fitted to a 2-compartment open model. The excretion of unchanged drug in urine was 52.75% of the dose in 32 h and the ClR was 143.79 ml.min-1.
Department of Pharmaceutics, Renji Hospital, Shanghai Second Medical University.
P Q
PQ
Wang
G H
GH
Lu
X B
XB
Zhou
J F
JF
Shen
S X
SX
Chen
S W
SW
Mei
M F
MF
Chen
D000328:Adult; D000470:Alkaloids / Q000493:pharmacokinetics*; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D011807:Quinolizines; D000093842:Matrines
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D011807:Quinolizines; D000093842:Matrines