Determination of IL6, IL1, and IL4 in the plasma of patients with multiple myeloma.
Interleukin 6 (IL6) plasma levels were measured in 63 patients with multiple myeloma and 8 individuals with benign monoclonal gammopathy. 15 of these 71 samples showed by an enzyme linked immunosorbent assay (ELISA) detectable levels that ranged from 5 to 107 pg of IL6/ml. The IL6 levels of patients with multiple myeloma did not differ significantly from those of normal individuals (N = 25, range 5-27 pg IL6/ml) (Student's t-test, p = 0.295). The samples were negative for IL4; 3 were found positive for IL1 beta. A correlation between IL6, IL4 and IL1 beta levels and disease status was not observed for this group of patients.
Ontario Cancer Institute, Institute of Medical Science, University of Toronto, Canada.
T L
TL
Kiss
J H
JH
Lipton
D E
DE
Bergsagel
J M
JM
Meharchand
N
N
Jamal
M D
MD
Minden
H A
HA
Messner
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000097:blood / Q000473:pathology; D009101:Multiple Myeloma / Q000097:blood* / Q000473:pathology; D010954:Plasmacytoma / Q000097:blood
D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D015847:Interleukin-4