[Acute hepatotoxicity with intermediate-dose methotrexate in children with leukemia and non-Hodgkin's lymphoma].
In the period of 1.1.1988 to 1.5.1992 49 children, 28 boys and 21 girls, were treated with 219 MTX infusions. The acute hepatotoxicity was investigated from day--1 to day 5 of treatment duration. 30 patients suffered of a ALL, 6 of a relapse of a ALL, 3 of a ANLL and 10 of a NHL. We studied the MTX dosage and the infusion time. At all patients the determination of the activity of the liver enzymes ASAT, ALAT and GGTP in the serum took place according to the treatment protocol. The increase of enzymes activity correlated with the intensity and kind of hepatocellular damage. Partly the extreme increase of lesion parameters is not the expression of an irreversible cytonecrosis. Beside the ALAT also the GGPT is a sensitive predictor of hepatocellular lesion. The high enzyme activity before the MTX application is a indicator of a preexistent cell damage of the liver. The hepatotoxicity measured in the serum was highly correlated with the AUC.
Abteilung Pädiatrische Hämatologie, Onkologie und Immunologie, Martin-Luther-Universität Halle-Wittenberg.
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P
Exadaktylos
T
T
Reiss
R
R
Schobess
M
M
Hommann
S
S
Höhne
A
A
Beck
D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy*; D008111:Liver Function Tests; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics
D008727:Methotrexate
Akute Hepatotoxizität bei mittelhochdosiertem Methotrexat bei Kindern mit Leukämien und Non-Hodgkin-Lymphomen.