[Lipid peroxidation and calcium transport in rat liver microsomes after chlorofos poisoning and the effect of atropine and verapamil].
Structural and functional state of rat hepatocytes endoplasmic reticulum membranes intoxicated with chlorofos (0,0-dimethyl-(1-oxy-2,2,21-trichloroethylphosphonate) was studied. It was shown that in case of intoxication a breakage of the membrane Ca(2+)-transport function was accompanied by modification of the membrane phospholipid lipoperoxidation processes and by conformational change of proteins. It is established that prophylactic injection of m-cholinolytic atropine and Ca(2+)-channel antagonist verapamil lead to normalization of processes of ATP-dependent potassium ion transport and lipid peroxidation processes (LPO) in the liver microsomal membranes of intoxicated animals.
Gubskiĭ
Iu I
IuI
Litvinova
N V
NV
Primak
R G
RG
Kurskaia
N M
NM
D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects; D005260:Female; D017136:Ion Transport / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014236:Trichlorfon / Q000506:poisoning*; D014700:Verapamil / Q000494:pharmacology*
D000931:Antidotes; D008315:Malondialdehyde; D001285:Atropine; D014700:Verapamil; D014236:Trichlorfon; D002118:Calcium
Perekisnoe okislenie lipidov i transport Ca2+ v mikrosomakh pecheni krys pri intoksikatsii khlorofosom i deĭstvii atropina i verapamila.