Comparative evaluation of determination of beta-lactam intermediates.
The Schiff's base formation between 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-aminocephalosporanic acid and p-dimethylaminobenzaldehyde (PDAB) was investigated. The factors that affect the reaction such as concentration of PDAB, time and pH were studied and optimised for estimation of these intermediates.
Hindustan Antibiotics Limited, Pimpri, Pune.
B S
BS
Deshpande
S S
SS
Ambedkar
J G
JG
Shewale
D001547:Benzaldehydes / Q000737:chemistry*; D002138:Calibration; D002511:Cephalosporins / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000737:chemistry; D007700:Kinetics; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*
D001547:Benzaldehydes; D002511:Cephalosporins; D007202:Indicators and Reagents; D012545:Schiff Bases; D010397:Penicillanic Acid; C014320:7-aminodesacetoxycephalosporanic acid; C004408:aminopenicillanic acid; C510241:p-dimethylaminobenzaldehyde