trans-epoxysuccinyl-L-leucylamido (4-guanidino)-butane (E-64) inhibits trypsin-catalysed hydrolysis possibly by binding in the S1-subsite.
Department of Biochemistry, Queen Mary & Westfield College, University of London, U.K.
S K
SK
Sreedharan
H N
HN
Shah
K
K
Brocklehurst
D000818:Animals; D001665:Binding Sites; D002384:Catalysis; D002417:Cattle; D006868:Hydrolysis; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D014361:Trypsin Inhibitors; D014357:Trypsin; D007930:Leucine; C024974:E 64