[Radiobiological aspects of increased radioresistance of murine epithelial stem cells from patches of Peyer].
The fraction of the survived intestinal crypts associated with patches of Peyer is higher to those non-patch-associated crypts of mice for three inbred strains. The difference in the survival between associated and non-patch-associated crypts increases with dose of gamma-irradiation. This difference for old mice is less than for young mice. Pre-irradiation (5 Gy) of mice one week before the conditioned gamma-irradiation cannot modify the difference in the survival between associated and non-patch-associated crypts. Radioprotection of mice by hypoxic gas mixture (10% O2) cannot modify this difference. Pre-treatment of mice by dextran-sulfate alone or in combination with hypoxic gas mixture decreased the survival of intestinal crypts associated with patches of Peyer to the level of non-path-associated crypts. The difference in the survival between two subpopulation of intestinal stem cells is less after neutron irradiation than after gamma-irradiation.
Konopliannikova
O A
OA
Konopliannikov
A G
AG
Vacek
A
A
D000375:Aging / Q000473:pathology; D000818:Animals; D016264:Dextran Sulfate / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D000860:Hypoxia / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010581:Peyer's Patches / Q000473:pathology / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011836:Radiation Tolerance; D013234:Stem Cells / Q000473:pathology / Q000528:radiation effects
D016264:Dextran Sulfate
Radiobiologicheskie aspekty povyshennoĭ radiorezistentnosti stvolovykh kletok épiteliia nonkogo kishechnika mysheĭ v zone Peĕrovykh bliashek.