Subcutaneous noradrenaline concentration increase in normal subjects during cold exposure evaluated by microdialysis.
Changes in local noradrenaline level in subcutaneous tissue were measured in four healthy males (23-33 years) during cold stimulation using a microdialysis technique. The subcutaneous dialysate noradrenaline concentration increased during cold exposure by a factor of 3.5 (P < 0.003). A correction factor due to plasma overflow of noradrenaline to subcutaneous tissue was calculated from noradrenaline infusion studies. This correction had a minimal effect on the observed increase in dialysate noradrenaline concentration and the level of significance was only slightly altered after correction for plasma overflow. The microdialysis technique in combination with a sensitive radioenzymatic noradrenaline assay may be useful to assess changes in local subcutaneous noradrenaline level in man during physiological stimulation.
Grønlund
B
B
Department of Internal Medicine and Endocrinology, Herlev Hospital, University of Copenhagen, Denmark.
Grønlund
L
L
Christensen
N J
NJ
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D003080:Cold Temperature; D006801:Humans; D008297:Male; D017551:Microdialysis; D009638:Norepinephrine / Q000097:blood* / Q000493:pharmacokinetics; D012881:Skin Temperature / Q000502:physiology
D009638:Norepinephrine