[Effects of dimercaptosuccinic acid per os on copper excretion in rat].
After dimercaptosuccinic acid (DMSA) was given intragastrically by gavage (ig) 0, 250, or 500 mg.kg-1 following in CuSO4 30 mg.kg-1 daily x 3 d in rats, the Cu contents of serum increased markedly within 1-12 h. When ig DMSA daily x 3 d, the excretion of Cu in urine per 24 h in the treated group was greatly promoted vs the control (P < 0.01), that in the 250 or 500 mg.kg-1 group were enhanced 2.4-3.8 and 5.8-7.8 times, respectively. That the excretion of Cu was increased in bile but not in feces suggested the plausible existence an enterohepatic circulation.
Yan
X M
XM
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Li
L
L
Liang
Y Y
YY
Tao
Z Q
ZQ
Xu
X H
XH
Chen
Z J
ZJ
Zhang
J S
JS
D000818:Animals; D001646:Bile / Q000378:metabolism; D003300:Copper / Q000378:metabolism / Q000652:urine*; D005243:Feces / Q000737:chemistry; D008297:Male; D051381:Rats; D004113:Succimer / Q000494:pharmacology*
D003300:Copper; D004113:Succimer