title: Circadian profiles of blood pressure and heart rate of apparently healthy metropolitan Japanese.
abstract: The circadian waveform in blood pressure (BP) and heart rate (HR) was explored in metropolitan Japanese. Clinically healthy subjects (50 women and 50 men, aged 40-59 years) were selected for the study of computing a peer-group reference standard. Hypertensive subjects diagnosed by conventional criteria (systolic(S)BP/diastolic(D)BP > or = 160/90 mmHg) also volunteered for this study. Each was to provide measurements of SBP, DBP, and HR at 15 min intervals over 48 h by using an ambulatory monitor ABPM-630 (Colin Medical, Komaki, Japan). Reference limits were computed as 90% prediction limits specified by the circadian stage. Data in intervals of 30 min, displaced by 15 min, were used for the computation of these limits. Those time-qualified reference limits were reconstructed as 'three-component chronodesms' with the two harmonics (12 h and 8 h) in conjunction with the fundamental period (24 h). The coefficient of harmonics needed was determined by discrete Fourier transform (DFT). A diagnosis based on office BP readings was confirmed chronobiologically. As a result, the circadian BP profiles did not exceed the upper limit in 27/107 hypertensives for SBP and in 30/107 hypertensives for DBP. In conclusion, chronobiologic approaches improve the sensitivity and the reliability of diagnosis.
authors.affiliation: Department of Medicine I, Tokyo Women's Medical College, Daini Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm / Q000502:physiology*; D015716:Electrocardiography, Ambulatory; D005260:Female; D005583:Fourier Analysis; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity