title: Effect of retinoic acid on contraction of collagen gel induced by fibroblasts.
abstract: Retinoic acid inhibited the contraction of collagen gel containing fibroblasts. Moreover, in its presence fibroblasts extensions were shorter, fewer collagen fibers were recognized, cell adhesiveness was inhibited concentration-dependently, and microfilaments appeared to be disrupted, resulting in morphological changes including loss of multipolar cell processes due to changes in cytoskeletal linkages.
authors.affiliation: Department of Orthodontics, Postgraduate School of Dentistry, University of Tokushima, Japan.
authors.forename: H S
authors.initials: HS
authors.lastname: Lew
authors.forename: M
authors.initials: M
authors.lastname: Tsuchihashi
authors.forename: S
authors.initials: S
authors.lastname: Tenshin
authors.forename: T
authors.initials: T
authors.lastname: Kawata
mesh_terms: D002448:Cell Adhesion; D002478:Cells, Cultured; D002648:Child; D003094:Collagen; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005881:Gingiva / Q000166:cytology; D006801:Humans; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D014212:Tretinoin; D003094:Collagen