title: Immunosurveillance of transfusion dependent thalassaemia and hepatitis B vaccination.
abstract: The study evaluates the probable alteration of the immune system in multitransfused thalassaemics and the modification of their immune response following administration of hepatitis B virus (HBV) vaccine. B-thalassaemics (n = 50) and EB-thalassaemics (n = 30) who received multiple blood transfusion for the chronic anaemic status had significant iron overload. They had high prevalence for hepatitis B carrier state and almost all were exposed to hepatitis B virus during the course of transfusion as shown by the positivity of hepatitis B virus markers. Thalassaemics in presence of iron overload have altered immune status in terms of depressed T-lymphocytes and raised immunoglobulins G and M. However, they showed 100 per cent seroconversion with production of antibody to hepatitis B surface antigen following Hepatitis B vaccination.
authors.affiliation: Society for Research, Haematology and Blood Transfusion, Calcutta.
authors.forename: M
authors.initials: M
authors.lastname: Mazumder
authors.forename: B
authors.initials: B
authors.lastname: Sengupta
authors.forename: M
authors.initials: M
authors.lastname: De
authors.forename: P
authors.initials: P
authors.lastname: Lahiri
authors.forename: D K
authors.initials: DK
authors.lastname: Bhattacharya
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D001803:Blood Transfusion; D002353:Carrier State / Q000276:immunology; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood; D006512:Hepatitis B Core Antigens / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D015166:Monitoring, Immunologic; D013601:T-Lymphocytes / Q000276:immunology; D017086:beta-Thalassemia / Q000276:immunology* / Q000628:therapy
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines