Genetic markers in hypercholesterolemic and normocholesterolemic Czech children.
The genetic background of polygenic hypercholesterolemia was studied in hypercholesterolemic children consuming a diet identical to control individuals with low cholesterol concentrations. Significantly higher frequencies of "disadvantage" alleles, usually combined with a higher LDL cholesterol, were found in hypercholesterolemic individuals when polymorphisms in apolipoprotein E, apolipoprotein B--XbaI and LDL receptor--PvuII were studied.
Poledne
R
R
Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Prague, Czech Republic.
Hubácek
J
J
Písa
Z
Z
Pistulková
H
H
Valenta
Z
Z
D001055:Apolipoproteins B / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D002648:Child; D002874:Chromosome Mapping; D003604:Czechoslovakia; D005819:Genetic Markers; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000235:genetics; D012016:Reference Values
D001055:Apolipoproteins B; D001057:Apolipoproteins E; D005819:Genetic Markers; D011973:Receptors, LDL