Complex patterns of [125I]omega-conotoxin GVIA binding site expression during postnatal rat brain development.
In the mature CNS, N-type calcium channels regulate neurotransmitter release. The role of these channels in developing brain is less clear. Study of [125I]omega-conotoxin GVIA binding sites in developing rat brain using autoradiography reveals that putative N-type channels appear and disappear in complex temporal-spatial profiles including: (1) gradual increase to adult levels (cerebral cortex); (2) substructure differentiation (cerebellum); (3) transient expression (pons); and, (4) selective depletion (medulla). Transient expression of N-type calcium channels may influence specific neurodevelopmental processes.
Filloux
F
F
Department of Neurology, University of Utah, Salt Lake City 84132.
Schapper
A
A
Naisbitt
S R
SR
Olivera
B M
BM
McIntosh
J M
JM
D000375:Aging / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000378:metabolism*; D015220:Calcium Channels / Q000096:biosynthesis* / Q000187:drug effects; D005260:Female; D007457:Iodine Radioisotopes; D008297:Male; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D007457:Iodine Radioisotopes; D010455:Peptides; D020866:omega-Conotoxin GVIA