title: META. 1. A program for the evaluation of metabolic transformation of chemicals.
abstract: A new metabolism program, META, is introduced. In this paper, the basic principles on which the program operates are described. META is an expert system, capable of predicting the sites of potential enzymatic attack and the nature of the chemicals formed by such metabolic transformations. It operates from dictionaries of transformation operators, created by experts to represent known metabolic paths.
authors.affiliation: Chemistry Department, Case Western Reserve University, Cleveland, Ohio 44106-7078.
authors.forename: G
authors.initials: G
authors.lastname: Klopman
authors.forename: M
authors.initials: M
authors.lastname: Dimayuga
authors.forename: J
authors.initials: J
authors.lastname: Talafous
mesh_terms: D003198:Computer Simulation; D005103:Expert Systems; D008954:Models, Biological; D008956:Models, Chemical; D015394:Molecular Structure; D012984:Software; D015262:Xenobiotics / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015262:Xenobiotics