MR gradient echo imaging of intravascular blood oxygenation: T2* determination in the presence of flow.
The T2* relaxation time of blood varies with its oxygen saturation. To evaluate the feasibility of imaging intravascular blood oxygenation in humans using a conventional 1.5T MR system, we have implemented a method to measure T2* of blood despite the presence of pulsatile flow. The method was tested in a) stationary and flow phantoms, b) blood samples at different levels of oxygen saturation, and c) a human hypoxia model. Our results demonstrate the ability of cardiac-triggered, flow compensated gradient echo imaging to obtain reproducible T2* measurements of flowing blood in vivo.
Chien
D
D
Department of Radiology, University of California-San Francisco.
Levin
D L
DL
Anderson
C M
CM
D016477:Artifacts; D001783:Blood Flow Velocity; D005240:Feasibility Studies; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008955:Models, Cardiovascular; D008961:Models, Structural; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D011150:Popliteal Artery / Q000033:anatomy & histology*; D011152:Popliteal Vein / Q000033:anatomy & histology*; D011673:Pulsatile Flow
D010100:Oxygen