title: Serum CA 125 concentrations in patients with benign ovarian tumours.
abstract: Serum CA 125 concentrations have been measured in 115 patients with histologically confirmed nonmalignant pelvic disease, that is, serous cystadenoma (n = 56), mucinous cystadenoma (n = 14), fibroma (n = 33), thecoma (n = 8), and Brenner tumour (n = 4). Increased CA 125 concentrations (> 35 KU/L) were found in 14 patients, with a range of 46-891 KU/L, a mean of 205 KU/L, and a median of 97 KU/L. The highest values were found in patients with ascites. Serial measurements in one patient showed a fall in the 2 days immediately after surgery, over the next 3 days showing a two- to three-fold increase, followed by a slow return to normal over the next 7 weeks. Elevated CA 125 levels may not indicate ovarian malignancy and do not differentiate between benign and malignant pelvic masses.
authors.affiliation: Department of Clinical Biochemistry, Thanet General Hospital, Margate, UK.
authors.forename: P K
authors.initials: PK
authors.lastname: Buamah
authors.forename: A W
authors.initials: AW
authors.lastname: Skillen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D001948:Brenner Tumor / Q000276:immunology; D003537:Cystadenoma / Q000276:immunology; D005260:Female; D005350:Fibroma / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000276:immunology*; D011863:Radioimmunoassay; D013798:Thecoma / Q000276:immunology
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate