[Mechanism and prevention of hemolysis in jaundiced infants in phototherapy].
It has been reported that the prolonged phototherapy results in decreased glutathione reductase (GR) activity in red blood cells. We found short-term phototherapy had the same side-effect. Besides it aggravates hemolysis of newborns during the therapy. This side-effect can be prevented by oral administration of Vit B2. Eighteen jaundiced infants who were given Vit B2 5mg three times a day during the phototherapy, and the control group of 16 patients were not given Vit B2. The results showed that the decrease of hemoglobin and the time of jaundice disappearance during the phototherapy were more favourable in the oral Vit B2 group than those of the control. These results indicated that the short-term phototherapy not only results in decreased GR activity in red blood cell, but also results in hemolysis of the newborn. This side-effect can be prevented by oral administration of Vit B2.
Wu
Z L
ZL
Department of Pediatrics, First Affiliated Hospital, Guangzhou Medical College.
Chen
F X
FX
Lai
Y H
YH
D000743:Anemia, Hemolytic / Q000209:etiology / Q000517:prevention & control*; D004912:Erythrocytes / Q000201:enzymology; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy*; D010789:Phototherapy / Q000009:adverse effects*; D012256:Riboflavin / Q000627:therapeutic use*
D005980:Glutathione Reductase; D012256:Riboflavin