title: Effects of low phosphate intake on bone and mineral metabolism and microbial protein synthesis in lambs.
abstract: Growing lambs were fed diets either low or adequate in phosphorus and their effects on Ca and P retention, bone formation and resorption and on ruminal microbial protein synthesis were measured. Plasma osteocalcin was used as an indicator of bone formation rate. Levels in plasma were lower in lambs fed the low P diet and were associated with a fall in plasma P concentration and reduced Ca and P retention. Low P intake had no effect on microbial protein synthesis or on bone resorption determined using urinary pyridinoline and deoxypyridinoline as markers. These results suggest that lack of mineral, rather than reduced ruminal microbial protein synthesis, is the main factor contributing to the reduction in bone formation rate seen in lambs fed low P diets.
authors.affiliation: Rowett Research Institute, Bucksburn, Aberdeen.
authors.forename: D
authors.initials: D
authors.lastname: Scott
authors.forename: S P
authors.initials: SP
authors.lastname: Robins
authors.forename: P
authors.initials: P
authors.lastname: Nicol
authors.forename: X B
authors.initials: XB
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Buchan
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D004032:Diet; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010710:Phosphates / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D010758:Phosphorus / Q000097:blood / Q000378:metabolism*; D014176:Protein Biosynthesis; D012417:Rumen / Q000378:metabolism* / Q000382:microbiology
chemical_list: D010710:Phosphates; D015675:Osteocalcin; D010758:Phosphorus; D002118:Calcium