title: Expoxidation of styrene and substituted styrenes by whole cells of Mycobacterium sp. M156.
abstract: Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. alpha-Methylstyrene was also epoxidised at a lower rate, while trans-beta-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.
authors.affiliation: ZENECA Bio Products, Billingham, Cleveland, U.K.
authors.forename: S R
authors.initials: SR
authors.lastname: Rigby
authors.forename: C S
authors.initials: CS
authors.lastname: Matthews
authors.forename: D J
authors.initials: DJ
authors.lastname: Leak
mesh_terms: D001711:Biotransformation; D002849:Chromatography, Gas; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D007700:Kinetics; D009161:Mycobacterium / Q000378:metabolism*; D009904:Optical Rotation; D013237:Stereoisomerism; D020058:Styrene; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D004852:Epoxy Compounds; D013343:Styrenes; D020058:Styrene; C013690:styrene oxide