Genetic reassortment of influenza C viruses in man.
We reported previously that the antigenicity of the haemagglutinin-esterase (HE) glycoprotein of the human influenza C virus strain C/Nara/1/85 was indistinguishable from that of strain C/Nara/82. However, the ribonuclease T1-oligonucleotide map of total virion RNA of C/Nara/1/85 differed remarkably from the map of C/Nara/82, resembling instead the map of C/Nara/2/85, which has an HE antigenicity dissimilar to C/Nara/82 and C/Nara/1/85. This observation raised the possibility that C/Nara/1/85 might have arisen by reassortment from two viruses closely related to C/Nara/82 and C/Nara/2/85, respectively. Here, we compared the total nucleotide sequence of the HE gene and partial sequences of the other genes of C/Nara/1/85 with those of C/Nara/82 and C/Nara/2/85. The results suggest that C/Nara/1/85 has inherited HE and NP genes from a C/Nara/82-related virus and the PB2, PB1, PA, M and NS genes from a C/Nara/2/85-related virus.
Peng
G
G
Department of Bacteriology, Yamagata University School of Medicine, Japan.
Hongo
S
S
Muraki
Y
Y
Sugawara
K
K
Nishimura
H
H
Kitame
F
F
Nakamura
K
K
D001483:Base Sequence; D003001:Cloning, Molecular; D005814:Genes, Viral / Q000235:genetics; D006389:Hemagglutinins, Viral / Q000235:genetics*; D006801:Humans; D009982:Gammainfluenzavirus / Q000235:genetics*; D007564:Japan; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014760:Viral Fusion Proteins; D014764:Viral Proteins / Q000235:genetics*
D006389:Hemagglutinins, Viral; D012367:RNA, Viral; D014760:Viral Fusion Proteins; D014764:Viral Proteins; C060814:hemagglutinin esterase