Serum fatty acid profiles in cystic fibrosis patients and their parents.
Fatty acid compositions of the major serum lipid classes from 43 cystic fibrosis (CF) homozygotes (CF patients), 36 obligate heterozygotes (parents of CF patients) and 34 controls were determined by capillary gas chromatography. Fatty acid compositions of the homozygote CF patients were skewed in the direction of relative essential fatty acid deficiency in comparison with the controls. Less pronounced, but similar deviations from normal, were observed in the heterozygotes. Homozygotes with normal fatty acid compositions and heterozygotes with considerably disturbed fatty acid profiles were found.
Christophe
A B
AB
Department of Endocrinology and Metabolic Diseases, University of Ghent, Belgium.
Warwick
W J
WJ
Holman
R T
RT
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000235:genetics; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000097:blood*; D008297:Male; D010290:Parents; D010743:Phospholipids / Q000097:blood / Q000737:chemistry
D005227:Fatty Acids; D008041:Linoleic Acids; D010743:Phospholipids; D019787:Linoleic Acid