Functional role of type I and type II interferons in antiviral defense.
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Müller
U
U
Institute of Molecular Biology I, University of Zürich, Switzerland.
Steinhoff
U
U
Reis
L F
LF
Hemmi
S
S
Pavlovic
J
J
Zinkernagel
R M
RM
Aguet
M
M
D018354:Alphavirus Infections / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004198:Disease Susceptibility; D007113:Immunity, Innate; D007370:Interferon Type I / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology*; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D008565:Membrane Proteins; D051379:Mice; D009154:Mutation; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000502:physiology*; D018353:Rhabdoviridae Infections / Q000276:immunology; D012672:Semliki forest virus; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000276:immunology*; D000096743:Interferon gamma Receptor
D000914:Antibodies, Viral; D007370:Interferon Type I; D007371:Interferon-gamma; D008565:Membrane Proteins; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor