title: [Mutagenic activity of copper phenoxyacetate complexes].
abstract: The mutagenic activity of phenoxyacetatocopper (II) complexes of the composition Cu(R-COO)2Ln-R = phenoxymethyl, L represents H2O (n = 3), phenazone (1), 4-nitropyridine N-oxide (1)--as well free phenoxyacetic acid and uncoordinated 4-nitropyridine N-oxide was tested against strains of Salmonella typhimurium (TA 100, TA 97 and TA 102) with or without metabolic activation. Using Ames methods in vitro, of the above-mentioned compounds only the 4-nitropyridine N-oxide complex in a concentration of 75 micrograms/dish, with 27.7% content of this neutral ligand) and this molecule ligand alone (in a concentration of 12.5 micrograms/dish) exhibited genotoxic effects. The relationship between the coordination-chemical properties and the biological effects of the compounds tested is discussed.
authors.affiliation: Katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava.
authors.forename: M
authors.initials: M
authors.lastname: Blahová
authors.forename: J
authors.initials: J
authors.lastname: Sokolík
authors.forename: N
authors.initials: N
authors.lastname: Lahitová
authors.forename: A
authors.initials: A
authors.lastname: Murín
mesh_terms: D003300:Copper / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens; D009942:Organometallic Compounds / Q000633:toxicity*; D010648:Phenylacetates / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D009153:Mutagens; D009942:Organometallic Compounds; D010648:Phenylacetates; D003300:Copper
vernacular_title: Mutagénna aktivita fenoxyacetátomednatých komplexov.