Circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil and doxorubicin: experimental study.
OBJECTIVE
To evaluate circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil with an anticancer drug.


METHODS
The viscosities and stability were evaluated in arterial flow of iodized oil and the emulsions. Doppler ultrasound was used to quantify the embolic effect in the arteries of rabbits. The behavior of doxorubicin and iodized oil in the rat cremaster muscle was studied with videomicroscopy.


RESULTS
The emulsions did not break up after injection, and the size of discontinuous-phase droplets did not change. The embolic effect did not correlate with viscosity. The thinnest water-in-oil emulsion had the lowest embolic effect and induced homogeneous distribution of iodized oil droplets in the arterial tree.


CONCLUSIONS
Changes in the formulation of emulsions obtained with the same proportions of drug and iodized oil change the distribution of iodized oil in the arterial tree, the location at which the drug is released, and the embolic effect.
de Baere
T
T
Department of Interventional Radiology, Institut Gustave Roussy, Villejuif, France.
Dufaux
J
J
Roche
A
A
Counnord
J L
JL
Berthault
M F
MF
Denys
A
A
Pappas
P
P
D000009:Abdominal Muscles / Q000098:blood supply; D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000187:drug effects; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004655:Emulsions; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008833:Microcirculation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D014783:Viscosity / Q000187:drug effects
D004655:Emulsions; D007459:Iodized Oil; D004317:Doxorubicin