title: Sleep and nocturnal mouthpiece IPPV efficiency in postpoliomyelitis ventilator users.
abstract: OBJECTIVE
  Intermittent positive pressure ventilation (IPPV) can be delivered via various oral, nasal, or oronasal interfaces as an alternative to tracheostomy for up to 24 h of ventilatory support. Nocturnal nasal IPPV is often associated with frequent transient but at times severe oxyhemoglobin desaturations (dSaO2s) and sleep fragmentation. The purpose of this study was to determine if nocturnal mouthpiece IPPV is also associated with dSaO2s and sleep disruption.
  
  
  METHODS
  Twenty-seven postpolio ventilator-assisted individuals (VAIs) using mouthpiece IPPV with little or no ventilator-free breathing time (VFBT) underwent nocturnal oxyhemoglobin saturation (SaO2) monitoring. In addition, 15 underwent nocturnal capnography and 13 underwent polysomnography.
  
  
  RESULTS
  Mean nocturnal SaO2 was normal in 22 of 27 and maximum end-tidal PCO2 was normal in 12 of 15 VAIs. Use of lipseal retention for nocturnal mouthpiece IPPV significantly improved blood gas values during sleep. The polysomnography results demonstrated relatively normal sleep efficiency.
  
  
  CONCLUSIONS
  Nocturnal mouthpiece IPPV is most effective with lipseal retention. It can provide normal alveolar ventilation and SaO2 during sleep for VAIs with little or no measurable vital capacity or VFBT. Because transient dSaO2s can be eliminated with lipseal retention, it may disrupt sleep less than nasal IPPV.
authors.affiliation: Department of Physical Medicine and Rehabilitation, UMD-New Jersey Medical School, Newark.
authors.forename: J R
authors.initials: JR
authors.lastname: Bach
authors.forename: A S
authors.initials: AS
authors.lastname: Alba
mesh_terms: D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation / Q000295:instrumentation*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis; D011051:Poliomyelitis / Q000150:complications*; D012131:Respiratory Insufficiency / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D012894:Sleep Stages
chemical_list: D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D010100:Oxygen