[Preoperative evaluation of drug resistant focal epilepsies with 123I-iomazenil SPECT. Comparison with vidio/EEG monitoring and postoperative results].
SPECT with the benzodiazepine receptor antagonist 123I-Iomazenil was performed in 33 patients with intractable partial seizures for pre-operative evaluation. The results combined with MRI and 99mTc-HMPAO-SPECT findings were compared with the video-assisted EEG monitoring ("gold standard") which localised the focus in 25 patients. 11 patients underwent surgical resection of the epileptogenic area and became seizure-free for a period up to 13 months. The Iomazenil SPECT had a significantly higher sensitivity compared to 99mTc-HMPAO in the visualization of an epileptogenic area and should be regularly used in the diagnostic of medically intractable partial seizures.
Venz
S
S
Strahlenklinik und Poliklinik, des Universitätsklinikums Rudolf, Virchow/W, FU Berlin, FRG.
Cordes
M
M
Straub
H B
HB
Hierholzer
J
J
Schröder
R
R
Richter
W
W
Schmitz
B
B
Meencke
H
H
Felix
R
R
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D015609:Organotechnetium Compounds; D010091:Oximes; D011184:Postoperative Period; D011237:Predictive Value of Tests; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D014741:Video Recording
D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D005442:Flumazenil; C063038:iomazenil
Präoperative Bewertung pharmakoresistenter fokaler Epilepsien mit der 123J-Iomazenil-SPECT. Vergleich mit dem Video/EEG-Monitoring und postoperativen Ergebnissen.