[Evaluation of a new commercial kit for emergency determination of serum myoglobin].
The usefulness of a nephelometric-based serum myoglobin assay kit in the early diagnosis of acute myocardial infarction was assessed in 92 consecutive patients admitted within 24 hours of the onset of spontaneous chest pain lasting > or = 20 minutes. The discharge diagnosis was acute myocardial infarction in 37 patients (40.2%), myocardial infarction lasting > or = 6 hours in 10, and no myocardial infarction in 45 (48.9%). The characteristic curve showed that the best differential diagnostic value was a serum myoglobin > or = 130 micrograms/l (sensitivity, 75.6%; specificity, 91.7%; positive-predictive value, 88%; negative-predictive value, 82%). The initial diagnosis was doubtful in 33 patients (36%) because of an inconclusive electrocardiogram. A serum myoglobin value of > or = 130 micrograms/l would have identified 9 of the 13 patients with acute myocardial infarction and all of the 20 patients without myocardial infarction, giving an accuracy of 84.8%. These results suggest that this new rapid, quantitative serum myoglobin assay would be useful in the evaluation of suspected myocardial infarction, especially in patients with an inconclusive electrocardiogram.
Georges
J L
JL
Clinique cardiologique pour adultes, hôpital Necker-Enfants malades, Paris, France.
Chopin
N
N
Sainte Marie
I
I
Tsocanakis
O
O
Le Feuvre
C
C
Vacheron
A
A
Bailly
M
M
D000368:Aged; D004630:Emergencies; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007120:Immunochemistry / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D009211:Myoglobin / Q000097:blood*; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D012372:ROC Curve
D009211:Myoglobin
Evaluation d'une nouvelle trousse commerciale pour le dosage en urgence de la myoglobine sérique.