title: Demonstration of neurofibrillary tangles and neuropil thread-like structures in spinal cord white matter in parkinsonism-dementia complex on Guam and in Guamanian amyotrophic lateral sclerosis.
abstract: This report concerns the demonstration and distribution of neurofibrillary tangles (NFTs), immunoreactive neuropil thread-like structures and dots in the spinal cord gray and white matter of six patients with parkinsonism-dementia complex on Guam and five patients with Guamanian amyotrophic lateral sclerosis (ALS). A monoclonal antibody to Alzheimer NFTs was used. NFTs were found in the spinal cord gray matter and white matter and all patients had immunoreactive neuropil thread-like structures and dots in the gray matter as well as in the white matter. They were particularly numerous in the lateral funiculus of patients with Guamanian ALS.
authors.affiliation: Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
authors.forename: T
authors.initials: T
authors.lastname: Umahara
authors.forename: A
authors.initials: A
authors.lastname: Hirano
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Shibata
authors.forename: S H
authors.initials: SH
authors.lastname: Yen
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D000911:Antibodies, Monoclonal; D003704:Dementia / Q000473:pathology*; D006141:Guam; D006801:Humans; D007150:Immunohistochemistry; D016874:Neurofibrillary Tangles / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal