title: Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism.
abstract: To assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked the LPS-induced depression of social investigation but had no effect on LPS-induced increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes in dehydrogenase activity of peritoneal macrophages.
authors.affiliation: INRA-INSERM U394, Bordeaux, France.
authors.forename: R M
authors.initials: RM
authors.lastname: Bluthé
authors.forename: V
authors.initials: V
authors.lastname: Walter
authors.forename: P
authors.initials: P
authors.lastname: Parnet
authors.forename: S
authors.initials: S
authors.lastname: Layé
authors.forename: J
authors.initials: J
authors.lastname: Lestage
authors.forename: D
authors.initials: D
authors.lastname: Verrier
authors.forename: S
authors.initials: S
authors.lastname: Poole
authors.forename: B E
authors.initials: BE
authors.lastname: Stenning
authors.forename: K W
authors.initials: KW
authors.lastname: Kelley
authors.forename: R
authors.initials: R
authors.lastname: Dantzer
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000097:blood; D008070:Lipopolysaccharides / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012803:Sick Role; D014628:Vagotomy
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides