Effect of leucopelargonin derivative from Ficus bengalensis Linn. on diabetic dogs.
Dimethoxy ether of Leucopelargonidin-3-0-alpha-L rhamnoside isolated from the bark of the Indian Banyan tree Ficus bengalensis Linn. was tested for antidiabetic effect. At a medium effective dose (100 mg/kg) on oral administration, the compound showed significant hypoglycemic and serum insulin raising action in normal as also moderately diabetic dogs (induced by alloxan) during a period of two hours. The mechanism of action of the glycoside compound seems to be similar to that of drugs which stimulate insulin secretion. On acute and chronic administration in single doses of 0.2-1.8 g/kg to different groups of mice and daily administration of 100, 250 and 500 mg/kg to rats for a period of one month respectively did not show any toxic effect and the compound was not lethal even at the high dose of 1.8 g/kg in experimental animals.
Augusti
K T
KT
Department of Biochemistry, University of Kerala.
Daniel
R S
RS
Cherian
S
S
Sheela
C G
CG
Nair
C R
CR
D000496:Alloxan; D000818:Animals; D000872:Anthocyanins; D001786:Blood Glucose / Q000032:analysis; D002839:Chromans / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004285:Dogs; D007004:Hypoglycemic Agents / Q000627:therapeutic use* / Q000633:toxicity; D007328:Insulin / Q000097:blood; D008362:Mannosides / Q000627:therapeutic use*
D000872:Anthocyanins; D001786:Blood Glucose; D002839:Chromans; D007004:Hypoglycemic Agents; D007328:Insulin; D008362:Mannosides; C087775:leucopelargonin; D000496:Alloxan