title: Langerhans cell histiocytosis of bone: MR imaging.
abstract: Magnetic resonance (MR) images of 12 pathologically proven lesions of Langerhans cell histiocytosis (LCH) of bone were reviewed retrospectively. MR identified all lesions, three of which were not identified on plain radiographs. In all cases, MR showed greater abnormality than did plain radiographs. With one exception, all lesions were hypointense on T1-weighted images and hyperintense on T2-weighted images. The lesions and associated soft tissue abnormalities were very conspicuous on short TI inversion sequences and T1-weighted post-contrast images. Follow-up MR studies in two patients after chemotherapy showed decreased size and enhancement of lesions compared with baseline studies.
authors.affiliation: Department of Radiology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46262.
authors.forename: J C
authors.initials: JC
authors.lastname: George
authors.forename: K A
authors.initials: KA
authors.lastname: Buckwalter
authors.forename: M D
authors.initials: MD
authors.lastname: Cohen
authors.forename: M K
authors.initials: MK
authors.lastname: Edwards
authors.forename: R R
authors.initials: RR
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D001847:Bone Diseases / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA