[Effect of acetylsalvianolic acid A on platelet function].
Acetylsalvianolic acid A (ASAA) is an semisynthetic analogue of salvianolic acid A, isolated from Danshen (Salvia miltiorrhiza Bunge). In in vitro experiments, ASAA showed marked inhibitory effect on rat and rabbit platelet aggregation induced by ADP, collagen, arachidonic acid (AA) and thrombin. In ex vivo experiments with ADP, collagen, and AA as inducers, ASAA was also shown to inhibit platelet aggregation remarkably. The effect lasted more than two hours. In addition, ASAA was found to have suppressive effect on collagen induced platelet 5-HT release while inhibiting aggregation. The above results seemed to suggest that ASAA may be a widely effective inhibitor of platelet function.
Yu
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WG
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Xu
L N
LN
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002109:Caffeic Acids / Q000494:pharmacology*; D007773:Lactates / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000097:blood
D002109:Caffeic Acids; D007773:Lactates; D010975:Platelet Aggregation Inhibitors; C090844:acetylsalvianolic acid A; D012701:Serotonin