[Eosinophil, beneficial or harmful: a cell entirely part of immune response].
The demonstration that human eosinophils could express various membrane receptors (for IgG, IgE, IgA; for complement; for cytokines; for chemotactic factors), for adhesion molecules (VLA4, LFAI, OKM1), as well as CD4 and class II MHC, has allowed to reconsider the role of eosinophils in immune response. Indeed, eosinophils can function as antigen presenting cells and can be infected by HIV. Studies on eosinophil mediators have revealed that eosinophils are not only the source of cytotoxic and proinflammatory mediators but can also release various cytokines and growth factors, including their own factors of differentiation (IL-3, GM-CSF and IL-5). The recent observation that eosinophils expressed IgE binding molecules belonging to different gene superfamilies (CD23, Mac2/epsilon BP and FceRI), as well as two different IgA receptors (Fc alpha R, and secretory component binding site), participating both in antiparasite immune defence and in inflammatory processes, reinforces the concept of the functional duality of eosinophils, specially in tissues.
Capron
M
M
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
Desreumaux
P
P
Gouni
A S
AS
Lamkhioued
B
B
Capron
A
A
D000917:Antibody Formation; D003602:Cytotoxicity, Immunologic; D004804:Eosinophils / Q000276:immunology*; D066298:In Vitro Techniques; D007249:Inflammation / Q000276:immunology; D007378:Interleukins / Q000276:immunology; D016028:Receptors, Leukocyte-Adhesion / Q000276:immunology
D007378:Interleukins; D016028:Receptors, Leukocyte-Adhesion
L'éosinophile, bénéfique ou néfaste: une cellule à part entière dans la réponse immunitaire.