Action of nitrogenated and sulfonylated inositol derivatives upon the proliferation in vitro of normal mouse cells and tumor mouse cells.
Despite the major advances of cancer chemotherapy during the past 40 years, host toxicities and drug resistance justify the need to continue the search for new antineoplastic agents. In the present work, we have studied the effect of six synthetic drugs on the in vitro growth of two murine mammary adenocarcinomas (M3 and MM3), as well as on normal embryonic cells. AI, MIC and MPI are purines coupled to a sulfonylated inositol, while DIC and DEI have nitrogen mustard as substituent. Methylsulfonylmucoinositol was the common substituent. Our results indicated that only drugs substituted with nitrogen mustards had an antiproliferative effect. DEI was more effective on tumor cells than on normal cells.
Eiján
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AM
Instituto de Oncología Angel H. Roffo, Universidad de Buenos Aires, Argentina.
Puricelli
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L
Bal de Kier Joffé
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Elías
C
C
Leicach
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SR
Cadenas
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D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis; D011687:Purines / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
C118646:3'-(1-chloroethyl)-2,3-dihydro-1H-imidazo(2,1-i)purine-4-ium-7-yl-3'-deoxy-1',5',6'-tri-O-(methylsulfonyl)-muco-inositol chloride; D000970:Antineoplastic Agents; D011687:Purines; D007294:Inositol