[Severe hyponatremia, possibly due to inappropriate antidiuretic hormone secretion, during use of the antidepressant fluoxetine].
In a 78-year-old female with hyponatraemia, the syndrome of inappropriate ADH secretion as a side effect of fluoxetine, a relatively new antidepressive drug, was tentatively diagnosed. In the literature 14 cases of this adverse reaction have been described. One should be careful when prescribing fluoxetine to elderly persons, notably when a diuretic is prescribed as well.
ten Holt
W L
WL
Rode Kruis Ziekenhuis, afd. Interne Geneeskunde, Beverwijk.
Klaassen
C H
CH
Schrijver
G
G
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000150:complications*; D008297:Male; D008875:Middle Aged
D005473:Fluoxetine
Ernstige hyponatriëmie, mogelijk door inadequate antidiuretisch-hormoonsecretie, bij gebruik van het antidepressivum fluoxetine.