Deletion (5q) in a desmoid tumor of a patient with Gardner's syndrome.
Desmoid tumors are associated with as many as 20% of cases of familial adenomatous polyposis (FAP) and Gardner's syndrome. In the present study, four specimens from different regions of a massive intraabdominal desmoid tumor from a 23-year-old white male with Gardner's syndrome were analyzed cytogenetically. Two different clonal abnormalities were observed. Two of the four specimens analyzed showed a del(5)(q14q31), which involves the region q21-->22 where the familial adenomatous polyposis gene is localized. In the two other specimens, a balanced translocation involving chromosomes 3 and 4 and an inv(4) was detected. Our findings confirm previous reports about the importance of chromosome defects on 5q in development of desmoid tumors, particularly in patients with Gardner's syndrome.
Dangel
A
A
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona.
Meloni
A M
AM
Lynch
H T
HT
Sandberg
A A
AA
D000328:Adult; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D002895:Chromosomes, Human, Pair 5; D018221:Fibromatosis, Abdominal / Q000235:genetics*; D005736:Gardner Syndrome / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male