Effect of retinoic acid on contraction of collagen gel induced by fibroblasts.
Retinoic acid inhibited the contraction of collagen gel containing fibroblasts. Moreover, in its presence fibroblasts extensions were shorter, fewer collagen fibers were recognized, cell adhesiveness was inhibited concentration-dependently, and microfilaments appeared to be disrupted, resulting in morphological changes including loss of multipolar cell processes due to changes in cytoskeletal linkages.
Lew
H S
HS
Department of Orthodontics, Postgraduate School of Dentistry, University of Tokushima, Japan.
Tsuchihashi
M
M
Tenshin
S
S
Kawata
T
T
D002448:Cell Adhesion; D002478:Cells, Cultured; D002648:Child; D003094:Collagen; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005881:Gingiva / Q000166:cytology; D006801:Humans; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin; D003094:Collagen