title: Oncogene amplification per se: an independent prognostic factor in human breast cancer.
abstract: As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2/FGF3, and c-erbB-2/neu) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the prognostic significance of oncogene amplification per se by multivariate analysis in a group of 112 primary human breast cancer cases. Amplification of at least one gene (c-myc, int-2/FGF3, or c-erbB-2/neu), progesterone receptor status, and pathological tumor size were the only independent variables predictive of metastasis-free survival. Moreover, we constructed prognostic profiles by computing risks associated with the three parameters predictive of poor survival and discriminated high-, moderate-, and low-risk categories.
authors.affiliation: Laboratoire d'Oncogénétique, Centre René Huguenin, Saint-Cloud, France.
authors.forename: M H
authors.initials: MH
authors.lastname: Champème
authors.forename: I
authors.initials: I
authors.lastname: Bièche
authors.forename: K
authors.initials: K
authors.lastname: Hacène
authors.forename: R
authors.initials: R
authors.lastname: Lidereau
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D018734:Genes, erbB-2; D016259:Genes, myc; D006801:Humans; D015999:Multivariate Analysis; D009857:Oncogenes; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: C496444:FGF3 protein, human; D051518:Fibroblast Growth Factor 3; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors