Gemfibrozil induced myositis: a case report with light microscopic and ultrastructural study.
A 49-year-old woman with chronic renal failure was given gemfibrozil for hyperlipidemia. She developed gemfibrozil-induced myositis which precipitated an acute compartment syndrome, necessitating emergency fasciotomy. The muscle biopsy showed prominent degeneration of the skeletal muscle fibers, associated with moderate chronic inflammatory infiltration. Electron microscopy revealed myofibrillary fragmentation and mitochondrial disorganization. The clinicopathologic features of gemfibrozil-induced myositis appear to be distinct from those of clofibrate-induced muscular syndrome. Extreme caution should be exercised in the use of gemfibrozil in patients with impaired renal function.
Chow
L T
LT
Institute of Pathology, Queen Elizabeth Hospital, Hong Kong.
Chow
W H
WH
D001706:Biopsy; D005260:Female; D015248:Gemfibrozil / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D009132:Muscles / Q000473:pathology; D009220:Myositis / Q000139:chemically induced / Q000473:pathology*
D015248:Gemfibrozil