Rheological behaviour of saturated polyglycolysed glycerides.
Seven saturated polyglycolysed glycerides (Gelucires) of melting points varying from 42 to 53 degrees C and hydrophilic-lipophilic balance values from 2 to 14 were selected. Their rheological behaviour was determined by adjustment of the flow curves to the Ostwald power-law and by statistical assessment of the flow index. The flow of Gelucires was slightly shear thickening. This shear thickening rose when the temperature and the lipophilic specificity of the Gelucire increased. This behaviour accounted for a reorganization of the particles under the shear which became easier when the temperature increased and when the degree of condensation of the polyethylene glycol chains decreased with lipophilicity of the Gelucires.
Bourret
E
E
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Limoges, France.
Ratsimbazafy
V
V
Maury
L
L
Brossard
C
C
D003692:Delayed-Action Preparations / Q000592:standards; D004304:Dosage Forms; D005989:Glycerides / Q000737:chemistry*; D006031:Glycosylation; D011092:Polyethylene Glycols / Q000737:chemistry; D012044:Regression Analysis; D012212:Rheology; D013696:Temperature; D014783:Viscosity
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D005989:Glycerides; D011092:Polyethylene Glycols