Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase.
A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.
Van Overbeke
A
A
Laboratory of Drug Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Belgium.
Baeyens
W
W
Van den Bossche
W
W
Dewaele
C
C
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification*; D001565:Benzoates; D002482:Cellulose / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D007202:Indicators and Reagents; D010666:Phenylpropionates; C090722:tris(4-methylbenzoate)cellulose; D002482:Cellulose