title: HM17, a new polyene antifungal antibiotic produced by a new strain of Spirillospora.
abstract: An antifungal antibiotic (HM17) was obtained from a new isolate classified to the genus Spirillospora on the basis of its chemical and morphological properties. On solid media this antibiotic strongly inhibited the growth of strains of Fusarium oxysporum formae speciales albedinis, Botrytis cinerea, Gaeumaniomyces graminis and several other fungi known to be plant and human pathogens. Antifungal activity in culture collection strains of Spirillospora has not so far been reported. The u.v. absorption spectrum and physico-chemical characteristics place HM17 in the methylpentaene sub-group of polyene macrolides. HM17 is different from other known methylpentaenes. This is the first report of polyene production by a Spirillospora.
authors.affiliation: Unité de Recherche sur les Zones Arides, Université des Sciences et de la Technologie Houari-Boumediène, Alger-Gare, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Hacène
authors.forename: K
authors.initials: K
authors.lastname: Kebir
authors.forename: D S
authors.initials: DS
authors.lastname: Othmane
authors.forename: G
authors.initials: G
authors.lastname: Lefebvre
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification / Q000648:ultrastructure; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002473:Cell Wall / Q000737:chemistry; D005285:Fermentation; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C091185:HM 17; D018942:Macrolides