title: Determination of methaqualone and its metabolites in urine and blood by UV, GC/FID and GC/MS.
abstract: A systematic procedure for the determination of methaqualone and its metabolites in blood and urine by UV spectrophotometry, GC and GC/MS was developed. Urine and blood samples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase and liquid-liquid extractions were used in the extraction and clean-up of the samples. The total amount of methaqualone and its metabolites was measured by UV spectrophotometry. The amount of parent methaqualone was quantitated by GC/FID. Methaqualone and its 10 metabolites including two acetyl metabolites were found in urine and blood. This procedure is useful for monitoring drugs in emergency treatment.
authors.affiliation: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: Y T
authors.initials: YT
authors.lastname: Liu
authors.forename: C L
authors.initials: CL
authors.lastname: Feng
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
mesh_terms: D002849:Chromatography, Gas; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D008702:Methaqualone / Q000032:analysis* / Q000378:metabolism* / Q000506:poisoning; D008875:Middle Aged; D013056:Spectrophotometry, Ultraviolet; D013406:Suicide, Attempted
chemical_list: D008702:Methaqualone