Efficacy of placebo in the treatment of patients with amenorrhea.
Thirty-two amenorrheic patients were treated with a tablet oral placebo preparation for a period varying from 30 to 180 days. Another 24 amenorrheic patients were also treated with a placebo administered i.m. for a period varying from 30 to 120 days. As a consequence of the treatment, 27 patients (48%) had menstrual bleedings. The progestogen withdrawal test responsive patients were more responsive to placebo (73 vs. 14% in the progestogen withdrawal test nonresponsive, p < 0.001). The time lag between starting the medication and the first bleeding varied between 4 and 120 days with a mean value of 33.9 (SD 26.3). Oral placebo was more effective than the intramuscular form (56 vs. 38%, p < 0.05).
Crosignani
P G
PG
I Department of Obstetrics and Gynaecology, University of Milan, Italy.
Mattei
A M
AM
Maggioni
P
P
Testa
G
G
Negri
E
E
D000284:Administration, Oral; D000568:Amenorrhea / Q000628:therapy*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D015990:Placebo Effect; D010919:Placebos / Q000008:administration & dosage; D011372:Progestins / Q000008:administration & dosage
D010919:Placebos; D011372:Progestins