The genetics of familial breast cancer and their practical implications.
A small proportion of breast cancer (perhaps about 5%) and a higher proportion of early onset cases are due to the inheritance of mutations in dominant susceptibility genes which confer a high lifetime risk of the disease. This would equate to about 1250 cases per year in the U.K. and 9000 in the U.S.A. Even within these cases, there is genetic heterogeneity, i.e. there are several genes involved, each giving rise to different patterns of other cancers associated with the familial breast cancer. One such gene (p53) has been identified and a second (BRCA1) has been precisely mapped in the human genome, but further breast cancer predisposition genes remain to be identified. In addition, there are other genes which confer a lower risk of the disease, but may account for a larger proportion of cases, the most important example to date being ataxia telangiectasia. The identification of these genes will enable the entity of familial breast cancer to be more precisely defined and has implications for management of gene carriers with breast cancer and their relatives who are at risk. A major consideration in this new area of cancer genetics is that the identification of gene carriers may become possible on a large scale and this raises ethical and social issues.
Eeles
R A
RA
CRC Academic Unit of Radiotherapy and Oncology, Royal Marsden Hospital, Sutton, Surrey, U.K.
Stratton
M R
MR
Goldgar
D E
DE
Easton
D F
DF
D000328:Adult; D000368:Aged; D001260:Ataxia Telangiectasia / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control; D004992:Ethics, Medical; D005190:Family; D005260:Female; D005799:Genes, Dominant; D016158:Genes, p53; D008040:Genetic Linkage; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged