title: [Sex and age-dependent gaps in tetanus immunization].
abstract: To test tetanus immunity, tetanus antitoxin titres were measured in the serum of 692 subjects (354 males, 338 females), aged one day (newborns) to 92 years (mean age 29 years). Those aged 18 to 65 years were first-time blood donors, the remainder were healthy newborns, while the children and those over 65 years were patients without immune-compromising disease. An inadequate protection (titre < 0.1 IU/ml) was found in 107 (15.5%), of whom 75 (70%) were females. Women aged 20 years and above also had significantly lower average antitoxin titres than men (1.7 vs. 3.5 IU/ml); P < 0.0001). The inadequate immunization protection of many young women is reflected in the lack of protective antibodies in 10 of the 49 examined newborns. In addition, 18% of children aged between 1 and 15 years had inadequate immunity against tetanus. In the whole group the titre level decreased with age, while the proportion of unprotected persons increased. Apart from the obvious age and sex dependency of the demonstrated inadequacy of immunological protection against tetanus, attention should also be paid to the lack of protective antibodies in newborns and the marked gaps of immunity among children.
authors.affiliation: Institut für Immunologie und Transfusionsmedizin, Medizinischen Universität Lübeck.
authors.forename: M
authors.initials: M
authors.lastname: Klouche
authors.forename: S
authors.initials: S
authors.lastname: Görg
authors.forename: D
authors.initials: D
authors.lastname: Wilhelm
authors.forename: H
authors.initials: H
authors.lastname: Kirchner
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013742:Tetanus / Q000276:immunology; D013743:Tetanus Antitoxin / Q000302:isolation & purification*
chemical_list: D013743:Tetanus Antitoxin
vernacular_title: Geschlechts- und altersabhängige Lücken im Tetanusimmunschutz.