title: Renal microangiopathy in the primary antiphospholipid syndrome: a case report with literature review.
abstract: We report the case of a 52-year-old male patient with recurrent thrombosis from 'primary antiphospholipid syndrome' who developed renal microangiopathy. Despite anticoagulant therapy with coumadin, serum creatinine progressively increased from 398 to 592 mumol/l and platelets decreased to 43,000. The patient responded to high-dose methylprednisolone and aspirin and the renal function improved. A review of the literature disclosed 4 other cases of association between primary antiphospholipid syndrome and renal microangiopathy. The clinical characteristics of these cases are discussed.
authors.affiliation: Department of Medicine, Vancouver General Hospital, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Domrongkitchaiporn
authors.forename: E C
authors.initials: EC
authors.lastname: Cameron
authors.forename: N
authors.initials: N
authors.lastname: Jetha
authors.forename: B O
authors.initials: BO
authors.lastname: Kassen
authors.forename: R A
authors.initials: RA
authors.lastname: Sutton
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D012077:Renal Artery; D013927:Thrombosis / Q000209:etiology*