[Bilateral carotid occlusion in the rat neonatally treated with capsaicin].
Bilateral carotid occlusion (BCO) was performed in pentobarbital anesthetized adult rats neonatally treated with capsaicin (50 mg/kg, sc, CNT rats). Pressor and ventilatory responses to BCO in CNT rats were compared with those of littermate controls injected with a same volume of solvent (olive oil, 0.1 ml). Capsaicin was used in order to produce partial degeneration of unmyelinated C fibres related to baroreflexes and peripheral chemoreflexes. In control rats, BCO provoked in less than 5 s, hyperventilation, hypocapnia and hyperoxia. Systemic arterial hypertension and tachycardia developed more slowly. They were maximum at 65 s. At this time, ventilation was returned to control values. Hyperventilation results from the stimulation of the carotid chemoreceptors by stagnant asphyxia generated by the blood flow stop. Hypertension and tachycardia are provoked by an increase in the orthosympathetic outflow when carotid baroreceptors are unloaded. In a first time, chemoreceptors stimulation tends to oppose to the increase of heart rate in normal rats. In a second one, development of hypertension is autolimited by the stimulation of the aortic baroreceptors particularly effective in rats. Simultaneously the hyperoxic inhibition from aortic chemoreceptors, the central hypocapnia and the reperfusion of the carotid bodies lead to the suppression of hyperventilation. As hyperventilation decreases when hypertension develops, even in rats with vago-sympathetic section at low cervical level, the part of aortic baroreceptors effects is probably reduced except for the fibres travelling through superior laryngeal nerves. Carotid bodies reperfusion seems to predominate. Before any manipulations, CNT rats had lower heart rate and systemic blood pressure than controls. During BCO, initial hyperventilation was moderately prolonged as hypertension slowly developed.(ABSTRACT TRUNCATED AT 250 WORDS)
Lagneaux
D
D
Institut Léon Fredericq, Physiologie, Université de Liège, Belgique.
Lecomte
J
J
D000818:Animals; D000831:Animals, Newborn; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000503:physiopathology*; D002211:Capsaicin / Q000494:pharmacology*; D002340:Carotid Artery Diseases / Q000150:complications / Q000503:physiopathology*; D002628:Chemoreceptor Cells / Q000502:physiology; D003714:Denervation; D018496:Hyperoxia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D006985:Hyperventilation / Q000209:etiology; D016857:Hypocapnia / Q000209:etiology; D007700:Kinetics; D051381:Rats; D017208:Rats, Wistar; D013610:Tachycardia / Q000209:etiology
D002211:Capsaicin
Occlusion bilatérale des carotides primitives chez le rat traité par capsicine à la naissance.