New nematicidal and antimicrobial compounds from the basidiomycete Cheimonophyllum candidissimum (Berk & Curt.) sing. I. Producing organism, fermentation, isolation, and biological activities.
Six new bisabolane type sesquiterpenoids, cheimonophyllons A (1), B (2), C (3), D (4), E (5), and cheimonophyllal (6) were isolated from the culture fluid of the basidiomycete, Cheimonophyllum candidissimum. The compounds exhibited nematicidal, weak antifungal and antibacterial as well as cytotoxic activities. The main product, cheimonophyllon A (1) (C15H22O4), was also active in the Ames mutagenicity test.
Stadler
M
M
Lehrbereich Biotechnologie, University of Kaiserslautern, Federal Republic of Germany.
Anke
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D002417:Cattle; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005285:Fermentation; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D012717:Sesquiterpenes