Aminooxyacetic acid-induced accumulation of GABA enhances clonidine hypotension.
The effect of 2-oxoglutarate aminotransferase inhibitor, aminooxyacetic acid (AOAA) on hypotension induced by clonidine in spontaneously hypertensive rats (SHR) was examined. AOAA given 15 min before clonidine significantly intensified clonidine--induced reduction of blood pressure. This effect reached its maximum within 120 min after AOAA administration, when AOAA itself had no influence on blood pressure. Our data suggest that the activation of functional state of GABAergic system by GABA accumulation potentiates clonidine hypotension.
Goźlińska
B
B
Department of Pharmacology, Drug Institute, Warszawa, Poland.
D000625:Aminooxyacetic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006973:Hypertension / Q000188:drug therapy*; D007022:Hypotension / Q000139:chemically induced*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D003000:Clonidine