title: Inhibition of myeloperoxidase release from rat polymorphonuclear leukocytes by a series of azachalcone derivatives.
abstract: A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.
authors.affiliation: Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
authors.forename: M L
authors.initials: ML
authors.lastname: Edwards
authors.forename: D M
authors.initials: DM
authors.lastname: Stemerick
authors.forename: J S
authors.initials: JS
authors.lastname: Sabol
authors.forename: K A
authors.initials: KA
authors.lastname: Diekema
authors.forename: R J
authors.initials: RJ
authors.lastname: Dinerstein
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D002351:Carrageenan; D016257:Fura-2; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D015759:Ionomycin / Q000494:pharmacology; D008297:Male; D008345:Manganese / Q000378:metabolism; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D009195:Peroxidase / Q000096:biosynthesis / Q000378:metabolism*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011725:Pyridines; C090932:1-phenyl-3-(4-pyridinyl)-2-propen-1-one; D008345:Manganese; D015759:Ionomycin; D009240:N-Formylmethionine Leucyl-Phenylalanine; D002351:Carrageenan; D009195:Peroxidase; D002118:Calcium; D016257:Fura-2