Randomized clinical trial comparing astigmatism and visual rehabilitation after penetrating keratoplasty with and without intraoperative suture adjustment.
OBJECTIVE
The authors performed a prospective, randomized clinical trial to compare postoperative astigmatism and visual rehabilitation after penetrating keratoplasty with and without intraoperative suture adjustment.


METHODS
Twenty-five patients undergoing penetrating keratoplasty for avascular corneal pathology randomly were assigned to two groups. All surgery was performed by one surgeon (ONS) using the same technique (except for intraoperative suture adjustment) with Hanna trephination (8 mm) and a running 10-0 nylon suture. Postoperative suture adjustment was done during the first postoperative month in all patients who had more than 3.5 diopters of astigmatism. Refraction and computerized topographic analysis were performed at 1 and 6 months postoperatively.


RESULTS
Intraoperative suture adjustment significantly decreased postkeratoplasty topographic (P = 0.0001) and refractive (P = 0.0001) astigmatism and improved best spectacle-corrected visual acuity (P = 0.0019) during the first postoperative month. Seventy-seven percent of control patients (mean topographic astigmatism, 4.89 +/- 1.99 D at 1 month), but no patients who underwent intraoperative suture adjustment (mean topographic astigmatism, 1.50 +/- 0.74 D at 1 month), required at least one postoperative suture adjustment that delayed optical stability and increased postoperative complications. At 6 months postoperatively, mean topographic (P = 0.06) and refractive (P = 0.0001) astigmatism were smaller in the intraoperatively adjusted group than in the control group with postoperative suture adjustments. After intraoperative adjustment, best spectacle-corrected visual acuity was better (P = 0.0168, P = 0.0434) and corneal topography was more regular (P = 0.02, P = 0.07, NS) at 1 and 6 months, respectively, than after postoperative adjustment.


CONCLUSIONS
Visual rehabilitation with decreased postkeratoplasty astigmatism and more regular corneal topography was attained more rapidly and safely with intraoperative suture adjustment.
Serdarevic
O N
ON
Department of Ophthalmology, Cornell University Medical College, New York.
Renard
G J
GJ
Pouliquen
Y
Y
D000328:Adult; D001251:Astigmatism / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D003315:Cornea / Q000502:physiology; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011446:Prospective Studies; D012046:Rehabilitation; D013536:Suture Techniques; D014785:Vision, Ocular / Q000502:physiology*; D014792:Visual Acuity