[Effect of nicardipine cardioplegia on A-V conduction system in coronary bypass surgery].
The effect of diltiazem and nicardipine cardioplegia on A-V conduction system was analyzed in 75 patients undergoing coronary bypass operation. The dose of these drugs into the crystalloid cardioplegia was 10 micrograms/kg in nicardipine group (n = 29) and 100 micrograms/kg in diltiazem group (n = 46). Among these patients, there was no operative death and no patient required IABP after surgery and there was no difference on the post operative CK-MB level, on the cardiac index and on the pulmonary pressure between two groups. The number of patients who had complete A-V block after release of aortic cross clamping was significantly smaller in nicardipine group than in diltiazem group: 45.7% in diltiazem group vs. 6.9% in nicardipine group at 30 minutes and 21.7% vs. 6.9% at 60 minutes. We conclude that the suppressive effect on A-V conduction system was significantly lower in nicardipine cardioplegia than in diltiazem cardioplegia in the patients undergoing coronary bypass operation.
Nukariya
M
M
Department of Thoracic and Cardiovascular Surgery, Juntendo University, Tokyo, Japan.
Hosoda
Y
Y
Kudou
H
H
Minami
S
S
Takazawa
K
K
Gotou
M
M
Satoh
T
T
Kikuchi
N
N
Watanabe
M
M
Tahara
M
M
D000787:Angina Pectoris / Q000503:physiopathology / Q000601:surgery; D001026:Coronary Artery Bypass; D004110:Diltiazem / Q000494:pharmacology; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009529:Nicardipine / Q000494:pharmacology*; D017680:Potassium Compounds / Q000494:pharmacology*
D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D009529:Nicardipine; D004110:Diltiazem