title: Hypothermic circulatory arrest and other methods of cerebral protection during operations on the thoracic aorta.
abstract: Current surgical techniques in operations on the thoracic aorta frequently require exclusion of the cerebral circulation for varying periods. During these periods, hypothermic circulatory arrest (HCA), selective cerebral perfusion (SCP), and retrograde cerebral perfusion (RCP) can be used for cerebral protection. Hypothermia is the principle component of these methods of protection. The main protective effect of hypothermia is based on reduction of cerebral energy expenditures and largely depends on adequate suppression of cerebral function. It is most effective at deep hypothermic levels (13 degrees C to 15 degrees C). Measures that preserve autoregulation of cerebral blood flow help increase the margin of safety with all methods of protection. There is solid experimental and clinical data indicating the safe limits and outcome following HCA. Current applications of SCP and RCP are fairly recent developments and do not have comparable supporting data. SCP can be used without deep hypothermia and allows prolonged periods of cerebral protection, but is complex in application. RCP is simpler, but always requires deep hypothermia. Present clinical data do not allow separation of its protective effect from that of HCA alone. Recent modifications in the application of HCA include monitoring of cerebral O2 extraction, and selective use of supplemental SCP to limit arrest times to less than 50 minutes, or RCP to prevent embolic strokes, as indicated. These changes appear to have reduced the overall mortality, the severity of embolic strokes, and stroke-related mortality.
authors.affiliation: Department of Cardiothoracic Surgery, Mount Sinai Medical Center, New York, New York 10029.
authors.forename: M A
authors.initials: MA
authors.lastname: Ergin
authors.forename: E B
authors.initials: EB
authors.lastname: Griepp
authors.forename: S L
authors.initials: SL
authors.lastname: Lansman
authors.forename: J D
authors.initials: JD
authors.lastname: Galla
authors.forename: M
authors.initials: M
authors.lastname: Levy
authors.forename: R B
authors.initials: RB
authors.lastname: Griepp
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery*; D001921:Brain / Q000098:blood supply; D001927:Brain Diseases / Q000209:etiology / Q000517:prevention & control*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods; D004285:Dogs; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D008875:Middle Aged; D010477:Perfusion / Q000295:instrumentation / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*