[The effects of the estradiol control delivery patch in the treatment of 176 cases of ovarian failure].
The effects of the estradiol control delivery patch made in China on the main manifestation in the 176 cases of ovarian failure patient were evaluated with the improvement of their symptoms, the changes of serum levels of LH, FSH, E2, the vaginal exfoliated cytologic maturation index (MI) and the histological alteration of endometrium. The results indicated that the six main symptoms including hectic fever, sweating, vaginal dry and hard-going, dizziness, emotioned lability and insomnia were improved significantly and progressively with prolongation of the treatment. The effective rates were 97.9%, 97.5%, 93.7%, 77.0%, 76.2%, 75.0% respectively form hectic fever to insomnia. The inhibitory effects on serum LH, FSH levels occurred on the 10th day of the treatment. The MI increased within whole course and the serum estradiol level elevated slightly and stably. There were no significant endometrial proliferation caused by the patch.
Shi
Y F
YF
Obstetric and Gynecologic Hospital, Zhejiang Medical University, Hangzhou.
Zhou
F Z
FZ
Lu
S M
SM
D000328:Adult; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy*; D014626:Vaginal Smears
D003692:Delayed-Action Preparations; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone