Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers.
We studied the pharmacokinetics of the enantiomers of mefloquine in whole blood in healthy Thai volunteers after administration of a single oral dose of 750 mg of the racemic mixture. Mefloquine pharmacokinetics were stereoselective. The peak concentrations and areas under the curve of the (-) enantiomer were significantly higher than those of its antipode (0.79 versus 0.46 microgram.ml-1 and 402 versus 94 micrograms.h.ml-1). The half-lives of (-)MQ were significantly longer than those of (+)MQ (531 versus 206 h). No stereoselectivity was observed for tmax values.
Martin
C
C
Hôpital Pitié Salpêtrière, Service Pharmacie-Pharmacocinétique, Paris, France.
Gimenez
F
F
Bangchang
K N
KN
Karbwang
J
J
Wainer
I W
IW
Farinotti
R
R
D000328:Adult; D044466:Asian People; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015767:Mefloquine / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D013237:Stereoisomerism
D015767:Mefloquine