title: Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men.
abstract: Caffeine is known to raise blood pressure (BP). We examined a single oral dose of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee) on BP in 18 hypertensive (HTN) and 12 age-matched, normotensive (NT) men for 3 h. Systolic BPs were significantly higher after caffeine for both groups (P < .001) for the entire 3 h. The HTN group showed persistent elevation in diastolic BP for 3 h, whereas the increment of diastolic BP became smaller in the NT group 90 min after caffeine ingestion. Our results suggest that caffeine consumption may affect both diagnosis and treatment of hypertension and abstinence from caffeine may be beneficial, especially for hypertensive individuals.
authors.affiliation: Department of Medicine, State University of New York.
authors.forename: B H
authors.initials: BH
authors.lastname: Sung
authors.forename: T L
authors.initials: TL
authors.lastname: Whitsett
authors.forename: W R
authors.initials: WR
authors.lastname: Lovallo
authors.forename: M
authors.initials: M
authors.lastname: al'Absi
authors.forename: G A
authors.initials: GA
authors.lastname: Pincomb
authors.forename: M F
authors.initials: MF
authors.lastname: Wilson
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D002110:Caffeine