Platinum and palladium complexes containing ethylenediamine derivatives as carrier ligands and their antitumor activity.
We prepared new antitumor active platinum complexes containing N,N'-bis(2-chloroethyl)ethylenediamine (ClEn) as an alkylating carrier ligand in order to obtain increased antitumor effects. Some of the platinum complexes synthesized showed enhanced antitumor activity. However, palladium(II) complexes containing ClEn were inactive against L1210 and P388.
Lee
K
K
Department of Pharmacy, Graduate School, Sookmyung Women's University Seoul, Korea.
Tashiro
T
T
Noji
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004337:Drug Carriers; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008024:Ligands; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010165:Palladium; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004337:Drug Carriers; D005029:Ethylenediamines; D008024:Ligands; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D010165:Palladium