Effects of feeding on the small intestinal mucosa of beagle pups during the first 5 d of life.
To further define the effects of feeding on small intestinal ontogeny, naturally suckled and formula-fed beagle pups were studied over the first 120 h of life. In suckled animals, proximal jejunal and midintestinal mucosal weight and protein and DNA contents increased > 75% by 24 h (P < 0.005), with no further increases at 120 h. In formula-fed pups, no mucosal mass changes were found between 0 and 72 h of life. At 120 h, proximal jejunal mucosal weight and protein and DNA contents were significantly greater than in newborns (P < 0.005) and were similar to values for suckled animals at the same time. No significant mid-intestinal or terminal ileal growth was noted in formula-fed pups at any time. Specific and total activities of proximal jejunal brush border lactase, sucrase, and alkaline phosphatase were significantly greater in suckled vs formula-fed animals at 120 h. In a parallel study to assess postnatal effects of mature milk vs colostrum, significant mucosal growth at 24 h of life was demonstrated in pups suckled by surrogate dams who had whelped 21 d previously. These data indicate that both natural suckling (colostrum or milk) and formula feeding support enteric mucosal growth in newborn dogs; however, the two feeding regimens are characterized by unique ontogenic patterns of intestinal mucosal growth and function.
Schwarz
S M
SM
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, NY.
Heird
W C
WC
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight; D004247:DNA / Q000378:metabolism; D004285:Dogs; D005502:Food; D007413:Intestinal Mucosa / Q000254:growth & development* / Q000502:physiology; D043322:Lactase; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008892:Milk; D009929:Organ Size; D011506:Proteins / Q000378:metabolism; D013393:Sucrase / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
D011506:Proteins; D004247:DNA; D000469:Alkaline Phosphatase; D043322:Lactase; D001616:beta-Galactosidase; D013393:Sucrase; D007931:Leucyl Aminopeptidase