[The relationship of the theophylline concentration in the saliva and the blood serum in patients with a broncho-obstructive syndrome].
Theophylline salivary and serum concentrations (Tser and Tsal) were quantified after a single dose administration of theophylline drugs: euphylline (2.4% solution, 10 ml i.v. jet and 0.15 orally), theo-dur, retaphil, theopek, theobilong (0.3 g orally). The drugs were given to patients with broncho-obstructive syndrome. The samples were obtained within 6 and 24 hours upon administration for euphylline and other drugs, respectively. Tser and Tsal were determined at high-performance liquid chromatography. The authors revealed a linear relationship between Tser and Tsal in different time intervals. The percentage factors and formulas of Tser calculation by its Tsal values have been estimated.
Tsoĭ
A N
AN
Gavrilenko
L N
LN
Kushkenbaeva
B E
BE
Kukes
V G
VG
D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D001982:Bronchial Diseases / Q000188:drug therapy / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000378:metabolism; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D013577:Syndrome; D013806:Theophylline / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D013997:Time Factors
D003692:Delayed-Action Preparations; D000628:Aminophylline; D013806:Theophylline
Izuchnie sviazi kontsentratsii teofillina v sliune i v syvorotke krovi u bol'nykh s bronkhoobstruktivnym sindromom.