title: Neuropsychological impairment in children with sickle cell anemia and cerebrovascular accidents.
abstract: Neuropsychological functioning of children with sickle cell anemia (HbSS) who have experienced a single stroke has not been extensively investigated. In this study, the neuropsychological functioning of 10 children with HbSS who were receiving transfusion therapy following stroke with no identifiable recurrence was examined. The patients were subgrouped into children with only left hemisphere stroke (LCI), N = 4, and those with only right hemisphere stroke (RCI), N = 6. Results indicated that these youngsters experienced significant impairments of cognitive functioning following stroke. It was found that the LCI and RCI children tended to perform more like adult stroke patients than what has been typically reported in children with infantile hemiplegia. These findings support the need for periodic neuropsychological evaluation following stroke in order to identify patterns of higher cortical dysfunction and assist in the development of appropriate rehabilitation and special education programs. Further, pediatricians, child neurologists, and psychologists who care for these children must act as strong advocates on their behalf in order to ensure that they receive appropriate rehabilitation and the special education services necessary for maximal recovery and future educational success.
authors.affiliation: Department of Neurology, Medical College of Georgia, Augusta.
authors.forename: M J
authors.initials: MJ
authors.lastname: Cohen
authors.forename: W B
authors.initials: WB
authors.lastname: Branch
authors.forename: V C
authors.initials: VC
authors.lastname: McKie
authors.forename: R J
authors.initials: RJ
authors.lastname: Adams
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D000755:Anemia, Sickle Cell / Q000150:complications*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000145:classification / Q000150:complications*; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D014888:Wechsler Scales