The catecholamine sensitivity of adult rats is enhanced after prenatal hypoxia.
In this study, the effect of prenatal hypoxia on the catecholamine sensitivity of the offspring of pregnant rats was investigated. The offspring from hypoxic animals showed after treatment with isoproterenol in adult age a distinctly more pronounced decrease of protein content and enzyme activities in heart tissue as well as a significantly higher elevation of enzyme activities in blood plasma as compared with the offspring from normoxic rats. These results suggest a long-lasting enhancement of catecholamine sensitivity after prenatal oxygen deficiency.
Heydeck
D
D
Humboldt University Medical School (Charité), Department of Pathological and Clinical Biochemistry, Berlin, Germany.
Roigas
J
J
Roigas
C
C
Papies
B
B
Lun
A
A
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001724:Birth Weight; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D000860:Hypoxia; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D007527:Isoenzymes; D011506:Proteins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D007545:Isoproterenol