Age-related changes in transcriptional and posttranscriptional regulation of the dopaminergic system.
Loss of striatal dopamine receptors is a major cause of decreased motor control and a robust biomarker of aging. Mechanisms of receptor loss include both neuronal death and decreased expression of receptor genes at the transcriptional and translational levels.
Roth
G S
GS
Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
Joseph
J A
JA
D000375:Aging / Q000502:physiology*; D000818:Animals; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000502:physiology*
D012333:RNA, Messenger; D011954:Receptors, Dopamine