title: Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.
abstract: Streptococcin A-M49 is produced by certain strains of M-type 49 group A streptococci. The structural gene for streptococcin A-M49 was cloned after hybridization with a probe containing the scnA lantibiotic structural gene. Sequence analysis revealed a duplication of the scnA gene; each gene (scnA' and scnA") encoded a 51-amino-acid prepeptide.
authors.affiliation: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
authors.forename: W L
authors.initials: WL
authors.lastname: Hynes
authors.forename: V L
authors.initials: VL
authors.lastname: Friend
authors.forename: J J
authors.initials: JJ
authors.lastname: Ferretti
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000378:metabolism; D001426:Bacterial Proteins; D001430:Bacteriocins; D001483:Base Sequence; D003001:Cloning, Molecular; D005798:Genes, Bacterial / Q000235:genetics*; D005822:Genetic Vectors; D008969:Molecular Sequence Data; D010455:Peptides; D013291:Streptococcus / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001430:Bacteriocins; D010455:Peptides; C090833:streptococcin A M49 protein, Streptococcus; C016887:A-FF22