Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant.
A causal relationship between sex steroids and meningioma proliferation has long been suspected. We report a case of the clinical progression of a sphenoid wing meningioma after the placement of Norplant, a subcutaneous contraceptive implant containing levonorgestrel, a progesterone agonist. Although not proof of causation, this observation lends further credence to the importance of progesterone receptors in the growth and possible treatment of meningiomas.
Piper
J G
JG
Division of Neurosurgery, University of Iowa Hospitals & Clinics, Iowa City.
Follett
K A
KA
Fantin
A
A
D000328:Adult; D004343:Drug Implants; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D008578:Meninges / Q000473:pathology; D008579:Meningioma / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D009376:Neoplasms, Hormone-Dependent / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D009460:Neurologic Examination; D011980:Receptors, Progesterone / Q000032:analysis / Q000187:drug effects
D004343:Drug Implants; D011980:Receptors, Progesterone; D016912:Levonorgestrel