title: Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism.
abstract: BACKGROUND
  Neck reexploration for primary hyperparathyroidism has a lower success rate and greater morbidity than initial exploration because of scarring and distortion of tissue planes and the possibility of a parathyroid neoplasm located in an ectopic or unusual position. Although the use of standard noninvasive imaging studies for reoperative parathyroid surgical procedure is well accepted, the use of invasive studies to localize parathyroid neoplasms, particularly percutaneous aspiration of potential lesions, is controversial. In this report we analyze the results and morbidity in patients undergoing fine-needle aspiration before neck reexploration.
  
  
  METHODS
  From 1982 to 1993, 255 patients underwent reexploration for persistent or recurrent hyperparathyroidism at the National Institutes of Health. Of these 255 patients 42 underwent 44 preoperative fine-needle aspirations by ultrasonography or computed tomography guidance in an attempt to localize a parathyroid neoplasm. The aspirated contents were then analyzed for parathyroid hormone content.
  
  
  RESULTS
  Of the 44 aspirations 26 (59%) were true positives with no false positives. Of 18 negative fine-needle aspirations, 11 (25%) were false negatives, and seven (16%) were true negatives. The specificity and sensitivity of percutaneous fine-needle aspiration were 100% and 70%, respectively.
  
  
  CONCLUSIONS
  Percutaneous fine-needle aspiration for parathyroid hormone is a safe, well-tolerated technique that is highly specific and allows a directed surgical resection avoiding further invasive workup when the aspirate is positive.
authors.affiliation: Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892.
authors.forename: M P
authors.initials: MP
authors.lastname: MacFarlane
authors.forename: D L
authors.initials: DL
authors.lastname: Fraker
authors.forename: T H
authors.initials: TH
authors.lastname: Shawker
authors.forename: J A
authors.initials: JA
authors.lastname: Norton
authors.forename: J L
authors.initials: JL
authors.lastname: Doppman
authors.forename: R A
authors.initials: RA
authors.lastname: Chang
authors.forename: M C
authors.initials: MC
authors.lastname: Skarulis
authors.forename: S J
authors.initials: SJ
authors.lastname: Marx
authors.forename: A M
authors.initials: AM
authors.lastname: Spiegel
authors.forename: H R
authors.initials: HR
authors.lastname: Alexander
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000032:analysis*; D012086:Reoperation
chemical_list: D010281:Parathyroid Hormone