title: [Systemic manifestations of rheumatoid arthritis: prognostic value of the HLA DRB1 0405 allele].
abstract: The aim of the present study was to determine HLA DRB1* genotype by PCR-RFLP analysis in patients with rheumatoid arthritis (N = 122) associated with extra-articular manifestations (N = 24). A significant increased of DRB1* 0405 was found in RA patients with extra-cellular involvement (odd-ratio = 8.33, confidence interval = 1.44 - 56.7). In patients with RA, HLA DRB1*0405 allele might constitute a susceptibility marker of extra-articular involvement such as vasulitis or cardio-pulmonary manifestations.
authors.affiliation: Service de rhumatologie, hôpital B, CHRU de Lille.
authors.forename: R M
authors.initials: RM
authors.lastname: Flipo
authors.forename: P M
authors.initials: PM
authors.lastname: Danze
authors.forename: V
authors.initials: V
authors.lastname: Castelain
authors.forename: P
authors.initials: P
authors.lastname: Coquerel
authors.forename: B
authors.initials: B
authors.lastname: Duquesnoy
authors.forename: J
authors.initials: J
authors.lastname: Rousseaux
authors.forename: B
authors.initials: B
authors.lastname: Delcambre
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000503:physiopathology; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D011379:Prognosis
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II
vernacular_title: Manifestations systémiques de la polyarthrite rhumatoïde: valeur pronostique de l'allèle HLA DRB1*0405.