Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets.
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. Replication of virus in the lower respiratory tract was also reduced > 100-fold, but three doses were required to prevent replication in the lungs. In ferrets infected with influenza B virus, single-dose treatment (40 mg/kg given intraperitoneally) produced a similar but reduced response in comparison with that in ferrets infected with influenza A virus, indicating that dosing was not optimal for this virus.
Jakeman
K J
KJ
School of Biological Sciences, Microbial Molecular Genetics and Cell Biology Research Group, University of Birmingham, United Kingdom.
Tisdale
M
M
Russell
S
S
Leone
A
A
Sweet
C
C
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005289:Ferrets; D009980:Influenza A virus / Q000187:drug effects*; D009981:Influenza B virus / Q000187:drug effects*; D011355:Prodrugs / Q000494:pharmacology*; D013997:Time Factors
C090721:2,6-diaminopurine-2'-fluororiboside; D000998:Antiviral Agents; D011355:Prodrugs; C083670:2'-deoxy-2'-fluoroguanosine; D003849:Deoxyguanosine; D000241:Adenosine