Cell reproduction: induction of M-phase events by cyclin-dependent cdc2 kinase.
Although a major concern in the development of multicellular organisms is cell differentiation, the construction of a multicellular system essentially depends on cell multiplication, which consists of genomic duplication and segregation. Recent progress has revealed that cyclin-dependent kinases (CDKs) are key components of a cell cycle engine that governs cell proliferation. This article focuses on how CDKs induce M-phase events characterized by nuclear membrane breakdown, chromosome condensation and mitotic spindle formation to assure genomic segregation.
Kishimoto
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Laboratory of Cell and Developmental Biology, Faculty of Biosciences, Tokyo Institute of Technology, Yokohama, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D002875:Chromosomes / Q000378:metabolism; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D005260:Female; D006657:Histones / Q000235:genetics / Q000378:metabolism; D016200:Maturation-Promoting Factor / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008969:Molecular Sequence Data; D013379:Substrate Specificity
D016213:Cyclins; D006657:Histones; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor