Naked megakaryocyte nuclei in bone marrows of patients with acquired immunodeficiency syndrome: a somewhat specific finding.
Naked megakaryocyte nuclei (NMN) were studied retrospectively in 100 bone marrow biopsy sections and aspirates from patients with acquired immunodeficiency syndrome (AIDS) and 124 non-AIDS controls. An NMN score was developed to semiquantitate the NMN. The AIDS bone marrows had an incidence of 97% and a mean NMN score of 2.24 which was a higher incidence and score than the control groups and was statistically significant. The control groups consisted of 20 chronic myeloproliferative disorders (incidence of 70% and score of 1.4); 24 cases of acute myelogenous leukemia and myelodysplastic syndrome (incidence of 29.2% and 0.46 score); 22 cases of non-AIDS immune thrombocytopenic purpura (incidence of 50% and 0.82 score); 11 cases of acute lymphocytic leukemia (0% incidence); 21 cases of anemia (52.4% incidence and 0.7 score); and 26 cases of lymphoma staging (35% incidence and 0.35 score). It is concluded that NMN are a very frequent and, with a high score, a specific finding in AIDS bone marrow examinations.
Gordon
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S
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Lee
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S
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D006402:Hematologic Diseases / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D015995:Prevalence; D012189:Retrospective Studies; D012680:Sensitivity and Specificity