title: Risk cross sections and their application to risk estimation in the galactic cosmic-ray environment.
abstract: Radiation risk cross sections (i.e. risks per particle fluence) are discussed in the context of estimating the risk of radiation-induced cancer on long-term space flights from the galactic cosmic radiation outside the confines of the earth's magnetic field. Such quantities are useful for handling effects not seen after low-LET radiation. Since appropriate cross-section functions for cancer induction for each particle species are not yet available, the conventional quality factor is used as an approximation to obtain numerical results for risks of excess cancer mortality. Risks are obtained for seven of the most radiosensitive organs as determined by the ICRP [stomach, colon, lung, bone marrow (BFO), bladder, esophagus and breast], beneath 10 g/cm2 aluminum shielding at solar minimum. Spectra are obtained for excess relative risk for each cancer per LET interval by calculating the average fluence-LET spectrum for the organ and converting to risk by multiplying by a factor proportional to R gamma L Q(L) before integrating over L, the unrestricted LET. Here R gamma is the risk coefficient for low-LET radiation (excess relative mortality per Sv) for the particular organ in question. The total risks of excess cancer mortality obtained are 1.3 and 1.1% to female and male crew, respectively, for a 1-year exposure at solar minimum. Uncertainties in these values are estimated to range between factors of 4 and 15 and are dominated by the biological uncertainties in the risk coefficients for low-LET radiation and in the LET (or energy) dependence of the risk cross sections (as approximated by the quality factor). The direct substitution of appropriate risk cross sections will eventually circumvent entirely the need to calculate, measure or use absorbed dose, equivalent dose and quality factor for such a high-energy charged-particle environment.
authors.affiliation: Department of Cell and Molecular Biology, Lawrence Berkeley Laboratory, Berkeley, California 94720.
authors.forename: S B
authors.initials: SB
authors.lastname: Curtis
authors.forename: J E
authors.initials: JE
authors.lastname: Nealy
authors.forename: J W
authors.initials: JW
authors.lastname: Wilson
mesh_terms: D018480:Astronauts; D003359:Cosmic Radiation; D005260:Female; D006801:Humans; D018499:Linear Energy Transfer; D008297:Male; D015233:Models, Statistical; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000401:mortality; D009928:Organ Specificity; D011336:Probability; D012307:Risk Factors; D012737:Sex Factors; D013026:Space Flight