How much does the kidney participate in the origin of primary hypertension?
The existence of a relationship between the kidney and arterial hypertension has long been known. Renal participation in the development of arterial hypertension has been clearly shown in different animal models that mimic human essential hypertension. Different theories have tried to explain the mechanism(s) underlying the renal participation in human hypertension. According to the data contained in the literature renal vasoconstriction is present in the kidney since the very early stages of the hypertensive disease and could constitute the mechanism facilitating the development of arterial hypertension.
Ruilope
L M
LM
Unidad de Hipertensión, Hospital 12 de Octubre, Madrid, Spain.
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007668:Kidney / Q000502:physiology*