Nebulized furosemide in infants with bronchopulmonary dysplasia.
The effects of 0.1 mg, 0.25 mg, 0.50 mg, and 1.0 mg of nebulized furosemide per kilogram of body weight on pulmonary functions were studied in eight preterm infants with bronchopulmonary dysplasia who were supported by mechanical ventilation. Doses of 1 mg/kg significantly improved lung compliance (51% at 2 hours after nebulization), pulmonary resistance (28% at 1 hour), and tidal volume (43% at 1 hour), starting as early as 30 minutes after the dose; the effect lasted for at least 4 hours in many of the infants and was not associated with diuresis or renal side effects.
Rastogi
A
A
Department of Pediatrics, Cook County Children's Hospital, Chicago, Illinois 60612.
Luayon
M
M
Ajayi
O A
OA
Pildes
R S
RS
D000403:Airway Resistance / Q000187:drug effects; D001835:Body Weight; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D009330:Nebulizers and Vaporizers; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D013990:Tidal Volume / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
D005665:Furosemide