title: Vascularity of meningiomas and neuromas: assessment with dynamic susceptibility-contrast MR imaging.
abstract: OBJECTIVE
  Dynamic susceptibility-contrast MR imaging provides hemodynamic information about normal and pathologic tissue of the brain. The purpose of this study was to determine the value of this technique in assessing the vascularity of meningiomas and neuromas.
  
  
  METHODS
  Sixteen patients with extraaxial brain tumors (eight meningiomas and eight neuromas) and seven subjects without evident brain lesions were studied with a conventional 1.5-T MR unit. Dynamic susceptibility-contrast MR imaging was done with a gradient-echo technique (33/23/10 degrees [TR/TE/flip angle]) during bolus IV injection of 0.15 mmol/kg gadopentetate dimeglumine. The integral of the rate of change in T2* (integral of delta R2*dt) was calculated and compared among the brain tumors and normal brain.
  
  
  RESULTS
  The mean integral of delta R2*dt value obtained was significantly higher in meningiomas than in neuromas (p < .001), which shows that meningiomas are generally more vascular than neuromas. We found no significant difference in the mean integral of delta R2*dt between neuromas and normal brain regions.
  
  
  CONCLUSIONS
  Dynamic susceptibility-contrast MR imaging provides information about the degree of the vascularity of meningiomas and neuromas that is not available with conventional MR imaging.
authors.affiliation: Department of Radiology, Fukui Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Kubota
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply; D003287:Contrast Media; D003937:Diagnosis, Differential; D004338:Drug Combinations; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008536:Meglumine; D008577:Meningeal Neoplasms / Q000098:blood supply* / Q000175:diagnosis; D008579:Meningioma / Q000098:blood supply* / Q000175:diagnosis; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000098:blood supply* / Q000175:diagnosis; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA