Hemoglobinuria in rats: a sensitive test of renal filtering and absorption of PEG-hemoglobin, a red blood cell substitute.
Hemoglobinuria, defined as hemoglobin or hemoglobin subunits in the urine, is an easily monitored, sensitive indicator of renal handling of hemoglobin-based blood substitutes. Hemoglobin tetramer dissociation increases filtration by the kidneys. When the rate of filtration exceeds reabsorption, hemoglobinuria occurs. This study investigates the renal filtration and absorption of polyethylene glycol-modified bovine hemoglobin by monitoring for hemoglobinuria in several model systems.
Gilbert
C
C
Enzon, Inc., Piscataway, NJ 08854.
Nho
K
K
Johnson
M
M
Linberg
R
R
Shorr
R
R
D000042:Absorption; D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D001810:Blood Volume; D002417:Cattle; D004195:Disease Models, Animal; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005919:Glomerular Filtration Rate; D006207:Half-Life; D006454:Hemoglobins / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006456:Hemoglobinuria / Q000209:etiology*; D008297:Male; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001802:Blood Substitutes; D006454:Hemoglobins; D011092:Polyethylene Glycols