title: The effect of MK-801 and imipramine on beta-adrenergic and 5-HT2 receptors in the chronic mild stress model of depression in rats.
abstract: Chronic exposure (8 weeks) to sequential application of mild stressors caused the increase in the density (Bmax) of beta-adrenergic and 5-HT2 receptors in the rat cerebral cortex. MK-801 given chronically (5 weeks) decreased beta-adrenergic receptors density in both control and stressed rats, whereas it decreased the density of 5-HT2 receptors in control rats only. On the other hand, imipramine administered for 5 weeks reduced the number of beta-adrenergic and 5-HT2 receptors in both control and stressed rats.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors.forename: V
authors.initials: V
authors.lastname: Klimek
authors.forename: M
authors.initials: M
authors.lastname: Papp
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000627:therapeutic use*; D007099:Imipramine / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D013315:Stress, Psychological / Q000188:drug therapy*
chemical_list: D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin; D004082:Dihydroalprenolol; D016291:Dizocilpine Maleate; D007650:Ketanserin; D007099:Imipramine