title: Concentrations of serum amyloid-A (SAA) and haptoglobin (HP) as parameters of inflammatory diseases in cattle.
abstract: The concentrations of the acute-phase proteins, serum amyloid-A (SAA) and haptoglobin (Hp), were determined in the plasma of healthy cows (n = 25) and cows with spontaneous acute (n = 6), subacute (n = 37), or chronic (n = 7) inflammatory diseases. The plasma concentration of SAA alone, Hp alone, and the Hp/SAA ratio, differed significantly (p < 0.001) between healthy animals and animals with inflammatory diseases. Plasma Hp concentrations in the group of cows with acute inflammatory diseases were significantly (p < 0.01) different from those in the group with chronic inflammatory diseases. Moreover, the Hp/SAA ratio in chronic inflammatory diseases was significantly different from this ratio in acute (p < 0.01) and subacute (p < 0.05) inflammatory diseases. It is therefore concluded that the plasma concentrations of SAA and Hp and the Hp/SAA ratio are useful parameters to distinguish healthy animals from animals with inflammation and can be helpful in distinguishing between acute and chronic of inflammatory diseases.
authors.affiliation: University of Utrecht, Faculty of Veterinary Medicine, Department of Veterinary Pathology, The Netherlands.
authors.forename: S P
authors.initials: SP
authors.lastname: Alsemgeest
authors.forename: H C
authors.initials: HC
authors.lastname: Kalsbeek
authors.forename: T
authors.initials: T
authors.lastname: Wensing
authors.forename: J P
authors.initials: JP
authors.lastname: Koeman
authors.forename: A M
authors.initials: AM
authors.lastname: van Ederen
authors.forename: E
authors.initials: E
authors.lastname: Gruys
mesh_terms: D000208:Acute Disease; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006242:Haptoglobins / Q000032:analysis*; D007249:Inflammation / Q000097:blood / Q000662:veterinary*; D000685:Serum Amyloid A Protein / Q000032:analysis*
chemical_list: D006242:Haptoglobins; D000685:Serum Amyloid A Protein