Amphetamine-like effect of l-deprenyl (selegiline) in drug discrimination studies.
l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine-like effects and their slow onset, it may not be surprising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse.
Yasar
S
S
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Medical School, Baltimore.
Bergman
J
J
D000661:Amphetamine / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D051381:Rats; D012453:Saimiri; D012642:Selegiline / Q000494:pharmacology*
D000662:Amphetamines; D012642:Selegiline; D000661:Amphetamine; D003913:Dextroamphetamine