title: Effect of interaural time differences on middle-latency and late auditory evoked magnetic fields.
abstract: To determine if interaural time differences (ITDs) in binaural stimuli affect the middle-latency auditory evoked fields (AEFs) in the same manner as they affect the N100m deflection, neuromagnetic responses were recorded over the whole head using a 122-channel SQUID magnetometer. Binaural stimuli were lateralized to three positions, left, midline, and right, on the basis of ITDs. The N100m was significantly larger to stimuli with contralaterally-leading ITDs than to stimuli with no, or with ipsilaterally-leading ITDs. Neither the P30m nor the P50m deflections of the middle-latency response were significantly affected by ITD, although the P30m showed a tendency, similar to but smaller than that of N100m, to be larger to stimuli with contralaterally-leading ITDs. In some subjects, the source location of the P50m was anterior and inferior to the sources of the P30m and N100m, which are generated in the superior surface of the temporal lobe. Sound-related muscular artifacts were seen in the posterior recording channels of one subject, and the contribution of this activity to the signals over the temporal area was determined.
authors.affiliation: Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland.
authors.forename: L
authors.initials: L
authors.lastname: McEvoy
authors.forename: J P
authors.initials: JP
authors.lastname: Mäkelä
authors.forename: M
authors.initials: M
authors.lastname: Hämäläinen
authors.forename: R
authors.initials: R
authors.lastname: Hari
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D013017:Sound Localization; D013702:Temporal Lobe / Q000502:physiology / Q000648:ultrastructure