[The effect of Lomir (isradipine) on the tolerance for physical loading and on the gas exchange indices of patients with primary pulmonary hypertension].
Spirometry and bicycle ergometry were performed before and 3 weeks, 6 months after lomir treatment (mean dose 10.62 +/- 2.59 mg/day) of 8 patients with primary pulmonary hypertension. It was found that 3 weeks of the treatment produced a significant increase in the maximum power working capacity and performance, in 6 months of the treatment there were positive trends in gas exchange: anaerobic threshold became higher and maximum oxygen consumption rose. Thus, lomir is recommended for management of primary pulmonary hypertension as it improves exercise tolerance and gas exchange measured by means of spirometry and bicycle ergometry useful both for evaluating functional condition of the patients and the disease advance as well as its response to the therapy conducted.
Chazova
I E
IE
Belenkov
Iu N
IuN
Mareev
V Iu
VIu
Floria
V G
VG
Sinitsyn
V E
VE
Nakonechnikov
S N
SN
D000328:Adult; D002908:Chronic Disease; D004341:Drug Evaluation; D005080:Exercise Test / Q000295:instrumentation / Q000379:methods; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D017275:Isradipine / Q000627:therapeutic use*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D013997:Time Factors
D017275:Isradipine
Vliianie lomira (isradipina) na tolerantnost' k fizicheskoĭ nagruzke i pokazateli gazoobmena u bol'nykh pervichnoĭ legochnoĭ gipertenzieĭ.