title: The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells.
abstract: Recent molecular characterization of new G protein-coupled receptors (GPCR) draw attention to alternative splicing as a source of structural diversity. After a brief overview of characterized GPCR splice variants, we will describe in more detail the functional properties of the PACAP type I receptor splice variants. Some of these variants are positively coupled to both adenylate cyclase (AC) and phospholipase C (PLC) whereas others do not elicit any stimulation of the PLC or display a qualitatively intermediate phenotype. The PACAP type I receptor is therefore one of the few examples in which alternative splicing is clearly linked to functional diversity.
authors.affiliation: CNRS-UPR 9023, CCIPE, Montpellier, France.
authors.forename: L
authors.initials: L
authors.lastname: Journot
authors.forename: D
authors.initials: D
authors.lastname: Spengler
authors.forename: C
authors.initials: C
authors.lastname: Pantaloni
authors.forename: A
authors.initials: A
authors.lastname: Dumuis
authors.forename: M
authors.initials: M
authors.lastname: Sebben
authors.forename: J
authors.initials: J
authors.lastname: Bockaert
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone / Q000737:chemistry / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone; D019204:GTP-Binding Proteins