Plexiform fibrohistiocytic tumour with novel phenotypic features.
Plexiform fibrohistiocytic tumour is a recently described type of fibrohistiocytic tumour, the differentiation pattern of which is poorly understood. A case representing the predominantly fibrohistiocytic type of the tumour is reported. Immunohistochemical analysis supports the histiocytic origin of this entity. The expression of EBM/11 and tissue transglutaminase both in fibroblast-like and histiocyte-like cells indicate that a single cell line produces the dual morphological features. It is proposed that a non-phagocytic epithelioid pattern of histiocytic differentiation characterizes this tumour.
Thomázy
V
V
Department of Pathology, University Medical School of Debrecen, Hungary.
Nagy
A
A
Gál
I
I
Nemes
Z
Z
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D011503:Transglutaminases; D000514:alpha 1-Antichymotrypsin; C067980:CD68 antigen, human; D000097382:CD68 Molecule