title: Characterizing organic mood syndrome, manic type.
abstract: The purpose of this study is to provide the first empirically based description of the clinical features of organic mood syndrome, manic type (OMS-M). During a recent 5-year period, 14,889 new patients presented for initial evaluation and care at our institute. Of these patients, a total of 12 cases of OMS-M were diagnosed. Evaluations were conducted using the Initial Evaluation Form, which was developed to be compatible with the DSM-III. The symptom profile of OMS-M was compared with that of "functional" manics (bipolar disorder, manic type [BD-M]). A variety of associated clinical factors were also assessed. The OMS-M patient demonstrated somewhat less severe acute symptomatology but more longstanding functional impairment than in BD-M. OMS-M patients also displayed a lower age at onset of illness and a higher level of perinatal problems and developmental delays compared with BD-M patients. The OMS-M group displayed a low family burden of mania. The most striking distinguishing feature of OMS-M was the prevalence of neurological disorders, with a surprisingly high prevalence of seizure disorders. Seizure disorders were more prevalent in OMS-M than in other organic brain syndromes (OBS).
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213.
authors.forename: J R
authors.initials: JR
authors.lastname: Cornelius
authors.forename: H
authors.initials: H
authors.lastname: Fabrega
authors.forename: J
authors.initials: J
authors.lastname: Mezzich
authors.forename: R F
authors.initials: RF
authors.lastname: Ulrich
authors.forename: M E
authors.initials: ME
authors.lastname: Thase
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D001925:Brain Damage, Chronic / Q000150:complications / Q000209:etiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D012307:Risk Factors