Synthesis and characterization of some novel substituted benzenesulphonamides of potential hypoglycemic activity.
Two series of substituted benzenesulphonamides (Va-e and VIa-e) have been synthesized from 4-methoxycarbonyl-1-[p-(acetylamino)benzenesulphonylimino]pyridini um ylide (II) with a view to investigate their pharmacological activity. The structure of the synthesized products was inferred from elemental and spectral data. The hypoglycemic effect, antimicrobial activity and toxicity of the possible chemotherapeutic agents were evaluated. Six of these products were effective, when administered at an oral dose of 100 mg/kg b. wt., inducing marked reduction in blood glucose level.
Hanna
M A
MA
Chemistry Department, Damiatta Faculty of Science Mansoura University, Egypt.
Said
S B
SB
Waly
M A
MA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000900:Anti-Bacterial Agents; D007004:Hypoglycemic Agents; D013449:Sulfonamides