[Tissue concentration of tegafur suppository in patients with head and neck cancer--concentration of 5-FU in cancer tissue].
Fifty patients with head and neck cancer were treated with tegafur suppository for 7 days preoperatively. The tissues were obtained during surgical operation and the concentrations of 5-FU in cancer tissue, normal tissue and blood were measured. It was revealed that a high concentration of 5-FU was seen in cancer tissue and then metastatic lymph nodes. The 5-FU concentration in cancer tissue was parallel with T stage of the patients. Subsites which showed a high concentration of 5-FU were nasal-paranasal cavity, tongue and mesopharynx. The tegafur suppository was useful because of the high concentration in cancer tissue and metastatic lymph nodes without any obvious side effects in the head and neck region.
Koja
S
S
Dept. of Otorhinolaryngology, University of the Ryukyus Faculty of Medicine.
Itokazu
T
T
Kamiya
S
S
Maeshiro
N
N
Yamauchi
M
M
Esu
H
H
Simoji
Y
Y
Kanazawa
T
T
Noda
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000032:analysis*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D010256:Paranasal Sinuses / Q000378:metabolism; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013488:Suppositories; D005641:Tegafur; D005472:Fluorouracil