title: Interleukin-10 and pentoxifylline inhibit C-reactive protein-induced tissue factor gene expression in peripheral human blood monocytes.
abstract: Fibrin deposition is an integral feature of the inflammatory response. In response to C-reactive protein (CRP), an acute-phase reactant, blood monocytes synthesize and express tissue factor (TF), the main initiator of blood coagulation. We report the inhibitory effect of interleukin 10 (IL-10) and that of pentoxifylline, a methyl xanthine derivative, on monocyte expression of TF activity, TF protein and TF mRNA in response to CRP. These agents may be of use in diseases where a TF-induced prothrombotic state is detrimental.
authors.affiliation: INSERM U294, CHU Xavier Bichat, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Ramani
authors.forename: F
authors.initials: F
authors.lastname: Khechai
authors.forename: V
authors.initials: V
authors.lastname: Ollivier
authors.forename: C
authors.initials: C
authors.lastname: Ternisien
authors.forename: F
authors.initials: F
authors.lastname: Bridey
authors.forename: J
authors.initials: J
authors.lastname: Hakim
authors.forename: D
authors.initials: D
authors.lastname: de Prost
mesh_terms: D002097:C-Reactive Protein / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D010431:Pentoxifylline / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D013925:Thromboplastin / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D016753:Interleukin-10; D002097:C-Reactive Protein; D013925:Thromboplastin; D010431:Pentoxifylline