title: The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5.
abstract: The gene for human excitatory amino acid transporter (EAAT1) was localized to the distal region of human chromosome 5p13 by in situ hybridization of metaphase chromosome spreads. Interspecific back-cross analysis identified the mouse Eaat1 locus in a region of 5p13 homology on mouse chromosome 15. Markers that are linked with EAAT1 on both human and mouse chromosomes include the receptors for leukemia inhibitory factor, interleukin-7, and prolactin. The Eaat1 locus appears not to be linked to the epilepsy mutant stg locus, which is also on chromosome 15. The EAAT1 locus is located in a region of 5p deletions that have been associated with mental retardation and microcephaly.
authors.affiliation: Vollum Institute for Advanced Biomedical Research, Portland, Oregon.
authors.forename: M A
authors.initials: MA
authors.lastname: Kirschner
authors.forename: J L
authors.initials: JL
authors.lastname: Arriza
authors.forename: N G
authors.initials: NG
authors.lastname: Copeland
authors.forename: D J
authors.initials: DJ
authors.lastname: Gilbert
authors.forename: N A
authors.initials: NA
authors.lastname: Jenkins
authors.forename: E
authors.initials: E
authors.lastname: Magenis
authors.forename: S G
authors.initials: SG
authors.lastname: Amara
mesh_terms: D026905:Amino Acid Transport Systems; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D003433:Crosses, Genetic; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D017403:In Situ Hybridization; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008831:Microcephaly / Q000235:genetics; D008969:Molecular Sequence Data; D009115:Muridae; D013045:Species Specificity
chemical_list: D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D018846:Excitatory Amino Acids; D005819:Genetic Markers