title: Amplification of a c-yes-1-related oncogene in canine lymphoid leukemia.
abstract: Genomic DNAs from 4 canine spontaneous lymphoid neoplasms were examined by Southern blot hybridization using 7 kinds of oncogene probes. Analysis using a human c-yes-1 cDNA probe revealed amplification of the proto-oncogene in a DNA sample from a dog with lymphoid leukemia. Its degree was about 4- to 8-fold in comparison with a control DNA sample from a healthy dog. The genomic abnormality of canine c-yes-1-related oncogene may have a role in the tumorigenesis of this neoplasm, although the significance of the structural change in this oncogene remains unclear.
authors.affiliation: Department of Veterinary Surgery, Faculty of Agriculture, Miyazaki University, Japan.
authors.forename: R B
authors.initials: RB
authors.lastname: Mina
authors.forename: S
authors.initials: S
authors.lastname: Tateyama
authors.forename: N
authors.initials: N
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: R
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Ohtsuka
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D018076:DNA, Complementary; D004273:DNA, Neoplasm / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000662:veterinary*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051575:Proto-Oncogene Proteins c-yes; D011519:Proto-Oncogenes; D019061:src-Family Kinases
chemical_list: D018076:DNA, Complementary; D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051575:Proto-Oncogene Proteins c-yes; D019061:src-Family Kinases