title: [Hyperparathyroidism due to parathyroid carcinoma located in the mediastinum].
abstract: Parathyroid gland carcinoma is a rare cause of primary hyperparathyroidism. The authors discuss the case of a 56-year-old man who presented with hypercalcemia and multiple bone lesions suggestive of tumor metastases. Laboratory and radiological investigations revealed primary hyperparathyroidism in a patient with evidence of osteitis fibrosa cystica, sustained by carcinoma of a mediastinal parathyroid gland. Early titration of parathyroid hormone (PTH) levels in all patients with hypercalcemia of unclear cause is important for early diagnosis of cases that are tumor-sustained and prevention of the most severe complications. The role of immunostaining with anti-PTH antibodies in demonstrating parathyroid gland tissue in ectopic and/or non-functioning primary tumors, as well as metastases, is also discussed.
authors.affiliation: U.O. Medicina III, Policlinico di Careggi, Firenze.
authors.forename: W
authors.initials: W
authors.lastname: Boddi
authors.forename: C
authors.initials: C
authors.lastname: Nozzoli
authors.forename: C
authors.initials: C
authors.lastname: Francois
authors.forename: A
authors.initials: A
authors.lastname: Amorosi
authors.forename: S
authors.initials: S
authors.lastname: Grifoni
authors.forename: A
authors.initials: A
authors.lastname: Morettini
authors.forename: J
authors.initials: J
authors.lastname: Olivotto
authors.forename: G
authors.initials: G
authors.lastname: Berni
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000209:etiology; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000209:etiology*; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000175:diagnosis / Q000209:etiology; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis
vernacular_title: Iperparatiroidismo da carcinoma delle paratiroidi a sede mediastinica.