title: Modafinil binds to the dopamine uptake carrier site with low affinity.
authors.affiliation: Stanford Sleep Disorders Center, Palo Alto, California.
authors.forename: E
authors.initials: E
authors.lastname: Mignot
authors.forename: S
authors.initials: S
authors.lastname: Nishino
authors.forename: C
authors.initials: C
authors.lastname: Guilleminault
authors.forename: W C
authors.initials: WC
authors.lastname: Dement
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001559:Benzhydryl Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D001667:Binding, Competitive / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000493:pharmacokinetics / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology; D050483:Dopamine Plasma Membrane Transport Proteins; D006168:Guinea Pigs; D006801:Humans; D008565:Membrane Proteins / Q000187:drug effects* / Q000502:physiology; D000077408:Modafinil; D009290:Narcolepsy / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000187:drug effects* / Q000502:physiology; D016548:Prosencephalon / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D050483:Dopamine Plasma Membrane Transport Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011954:Receptors, Dopamine; D000077408:Modafinil