The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells.
Recent molecular characterization of new G protein-coupled receptors (GPCR) draw attention to alternative splicing as a source of structural diversity. After a brief overview of characterized GPCR splice variants, we will describe in more detail the functional properties of the PACAP type I receptor splice variants. Some of these variants are positively coupled to both adenylate cyclase (AC) and phospholipase C (PLC) whereas others do not elicit any stimulation of the PLC or display a qualitatively intermediate phenotype. The PACAP type I receptor is therefore one of the few examples in which alternative splicing is clearly linked to functional diversity.
Journot
L
L
CNRS-UPR 9023, CCIPE, Montpellier, France.
Spengler
D
D
Pantaloni
C
C
Dumuis
A
A
Sebben
M
M
Bockaert
J
J
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone / Q000737:chemistry / Q000502:physiology*
D011956:Receptors, Cell Surface; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone; D019204:GTP-Binding Proteins