Captopril and its probable contaminants: NMR and MS features of analytical value.
The 400 MHz 1H NMR spectrum of captopril in a variety of solvents is analysed and compared with those of epicaptopril and its disulphide analogue. A method for detecting isomeric and oxidative impurities by examination of a 1H NMR spectrum of captopril in DMSO-d6 is proposed. 13C NMR and MS data enable differentiation of captopril from its disulphide analogue but not from its diastereoisomer epicaptopril.
Casy
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AF
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
Dewar
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GH
D002216:Captopril / Q000032:analysis*; D004220:Disulfides / Q000032:analysis; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013237:Stereoisomerism
D004220:Disulfides; D002216:Captopril