title: Review of investigative diagnostic techniques for cutaneous lymphoma.
abstract: This article reviews the contribution of modern investigative techniques to the diagnosis of cutaneous lymphoproliferative diseases. Special attention is given to the significance of immunoglobulin and T-cell receptor rearrangements; as detected by Southern blotting and/or the polymerase chain reaction. Additional topics discussed include immunohistochemistry, cytogenetics, onco- and tumour suppressor genes and in-situ hybridization. It is recommended that the results of these techniques are interpreted in the form of a multifaceted diagnostic profile.
authors.affiliation: Department of Histopathology, Rotherham Hospital NHS Trust, United Kingdom.
authors.forename: D N
authors.initials: DN
authors.lastname: Slater
mesh_terms: D015139:Blotting, Southern; D015321:Gene Rearrangement / Q000276:immunology; D005819:Genetic Markers; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D005819:Genetic Markers