Conjugated dienes in selected organs of mice treated with doxorubicin and 4'-epi-doxorubicin. Part I.
The purpose of this study was to evaluate in vivo the influence of doxorubicin (DOX) and its less cardiotoxic analog 4'-epi-doxorubicin (EPI) on lipid peroxidation. The content of conjugated dienes (CD) in heart, liver and lungs of Balb/c mice was measured over a 24-h period at various time-points [1.5 and 24 h] after a single intravenous injection of either DOX or EPI. A statistically significant (p < 0.01) increase in CD levels was seen in mice heart extracts 24 h after treatment with DOX. No statistically significant increase in CD content was seen in any other group of animals treated with either DOX or EPI up to 24 h. The data presented in this paper indicate that DOX, but not EPI, induces lipid peroxidation in cardiac muscle.
Drzewoski
J
J
Department of Clinical Pharmacology, School of Pharmacology, Medical Academy, Lódź, Poland.
Pierściński
G
G
Nowak
D
D
D000818:Animals; D004317:Doxorubicin / Q000633:toxicity*; D015251:Epirubicin / Q000633:toxicity*; D005609:Free Radicals; D006321:Heart / Q000187:drug effects; D007275:Injections, Intravenous; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism
D005609:Free Radicals; D015251:Epirubicin; D004317:Doxorubicin