Increased 11-dehydrothromboxane B2 in migraine: platelet hyperfunction in patients with migraine during headache-free period.
Several disturbances in platelet function have been reported in migraine and tension-type headache (TH). The plasma 11-dehydrothromboxane B2 (11-dTXB2) is free from artifactual increase during blood sampling, and it can be a reliable indicator of thromboxane A2 (TXA2) production in vivo. TXA2 is a very potent proaggregatory and vasoconstrictory metabolite formed in the platelets. We investigated plasma 11-dTXB2 and 5-hydroxytryptamine (5-HT) levels in patients with migraine during headache-free periods and in patients with chronic TH. The mean value of plasma 11-dTXB2 levels in migrainous patients was significantly higher than those in TH patients and healthy controls. The mean value of plasma 5-HT levels in TH patients was significantly lower than those in migrainous patients and healthy controls. There was no correlation between plasma 11-dTXB2 levels and plasma 5-HT levels in any group. The results suggest the existence of continuous platelet activation in migrainous patients.
Kitano
A
A
Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
Shimomura
T
T
Takeshima
T
T
Takahashi
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000503:physiopathology; D015539:Platelet Activation; D012701:Serotonin / Q000097:blood; D018781:Tension-Type Headache / Q000097:blood / Q000503:physiopathology; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000097:blood
D012701:Serotonin; D013929:Thromboxane B2; C049235:11-dehydro-thromboxane B2