[acute dystonias in combined abuse of cocaine and neuroleptics].
A 25-year-old mildly retarded black cocaine user was hospitalized 15 times in 10 years for recurrent maniform psychosis. During the last intake he developed severe dystonia following zuclopenthixol 50 mg and droperidol 10 mg i.m. In view of current knowledge regarding the pathophysiology of acute neuroleptic induced dystonias, this suggests that cocaine may be a risk factor for development of acute dystonia. However, only a few studies with small numbers of patients and/or poor design have been reported. Therefore the conclusion cannot be drawn that an anticholinergic should be added to neuroleptics in patients with cocaine abuse.
Horwitz
E H
EH
Psychiatrisch Ziekenhuis Dr. David Ricardo Capriles Kliniek, Curaçao, Nederlandse Antillen.
van Harten
P N
PN
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001712:Biperiden / Q000627:therapeutic use; D003006:Clopenthixol / Q000009:adverse effects; D003042:Cocaine / Q000009:adverse effects*; D004329:Droperidol / Q000009:adverse effects; D004421:Dystonia / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000150:complications*
D014150:Antipsychotic Agents; D001712:Biperiden; D003006:Clopenthixol; D003042:Cocaine; D004329:Droperidol
Acute dystonieën bij gecombineerd gebruik van cocaïne en neuroleptica.