Investigation of synergism with combinations of dibromopropamidine isethionate or propamidine isethionate and polymyxin B.
Combinations of polymyxin B and dibromopropamidine isethionate exhibited synergistic inhibitory and bactericidal activity against Pseudomonas aeruginosa, Enterobacter cloacae, Proteus mirabilis, Escherichia coli and Staphylococcus aureus. Similar results were obtained with polymyxin B plus propamidine combinations except that propamidine was not as active as dibromopropamidine and the combination of polymyxin B plus propamidine against S. aureus only had additive activity. The antibacterial agents were tested in solutions and in a cream formulation. The findings indicate a potential for the use of selected combinations of these antibacterial agents in the treatment of wound and superficial eye infections.
Richards
M R
MR
School of Pharmacy, Robert Gordon University, Aberdeen, UK.
Xing
D K
DK
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D001550:Benzamidines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004058:Diffusion; D004357:Drug Synergism; D016972:Enterobacter cloacae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D015817:Eye Infections / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D001550:Benzamidines; C053597:dibrompropamidine; C046651:propamidine isethionate; D011112:Polymyxin B