The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761.
Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5 mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide.
Marcocci
L
L
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Maguire
J J
JJ
Droy-Lefaix
M T
MT
Packer
L
L
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D002417:Cattle; D016166:Free Radical Scavengers; D020441:Ginkgo biloba; D005949:Glucose Oxidase / Q000378:metabolism*; D007700:Kinetics; D009569:Nitric Oxide / Q000737:chemistry; D009573:Nitrites / Q000032:analysis; D009599:Nitroprusside / Q000737:chemistry*; D010108:Oxyhemoglobins / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D000096983:Ginkgo Extract
D002374:Catalase; D016166:Free Radical Scavengers; D005949:Glucose Oxidase; D009569:Nitric Oxide; D009573:Nitrites; D009599:Nitroprusside; D010108:Oxyhemoglobins; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract