title: [A beta-casein gene fragment is located in region 1p3 of human chromosome 1].
abstract: Analysis of the nucleotide sequence of a cloned fragment of the human beta-casein gene was performed. A conserved DNA locus, present with a varying degree of degeneracy in introns of [beta]-casein genes of several species and in the intron of an oncogene of the sarc family, was revealed. It was located in region 1p31-32 by means of in situ hybridization. A clearly visible additional hybridization site was observed in region 1p36. The data obtained are discussed in the light of available information on several oncogenes that are located in region 1p3. A relation was found between this region and the occurrence of some cancers, including breast cancer.
authors.forename: M V
authors.initials: MV
authors.lastname: Kost
authors.forename: A A
authors.initials: AA
authors.lastname: Baev
authors.forename: A A
authors.initials: AA
authors.lastname: Alimov
authors.forename: L I
authors.initials: LI
authors.lastname: Fedorova
authors.forename: A V
authors.initials: AV
authors.lastname: Zelenin
mesh_terms: D001483:Base Sequence; D002364:Caseins / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D005091:Exons; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009857:Oncogenes
chemical_list: D002364:Caseins
vernacular_title: Fragment beta-kazeinovogo gena lokalizovan v oblasti 1p3 pervoĭ khromosomy cheloveka.