Pulmonary vascular resistance distribution and recruitment of microvascular surface area.
To test the hypothesis that the distribution of hemodynamic resistance is involved in the control of pulmonary capillary surface area, we measured permeability-surface area product (PS) and longitudinal resistance distribution (LRD) as functions of perfusion rate in isolated rabbit lungs under zone II conditions (n = 10) and through the zone II-III transition (n = 4). PS, considered to be indicative of functioning capillary surface area, was measured with the aid of the diffusion-limited tracer [14C]propanediol, whereas LRD was determined using a viscous bolus technique. LRD was seen to change character with increasing flow and increasing PS/surface area, becoming bimodal with low central resistance as full capillary recruitment was approached in zone III. Effects of hypoxic ventilation were studied in zone II in five lungs; it was found that hypoxia altered the LRD and eradicated the normoxic dependence of PS/surface area on perfusion rate. It was concluded that LRD is involved in the determination of functioning capillary surface area.
Overholser
K A
KA
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235.
Lomangino
N A
NA
Parker
R E
RE
Pou
N A
NA
Harris
T R
TR
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D015633:Extravascular Lung Water / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply*; D011409:Propylene Glycols; D011817:Rabbits; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology; D014783:Viscosity
D011409:Propylene Glycols