[T-lymphocyte subpopulations in tuberculosis in middle aged and aged patients].
The role of T-lymphocyte subpopulations in regulation of immunity was studied using monoclonal antibodies OKT-4 and OKT-8 in tuberculous patients and healthy subjects of different age. Basing on the examination of 174 patients, it was established that in older subjects pulmonary tuberculosis runs in the presence of aged-related changes in the immune system: an increase in the number of T-suppressors, a reduction in that of T-helpers, secondary immunodeficiency dependent on the process severity and forms. These shifts are suggested to be responsible for the inadequate immune response to M. tuberculosis in the elderly.
Adambekov
D A
DA
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
Subpopuliatsiia T-limfotsitov pri tuberkuleze u lits pozhilogo i starcheskogo vozrasta.