[CD classification of lymphocytes and the function: significance of flow cytometric analysis in immunoneurological disorders].
We reviewed flow cytometric studies of lymphocyte subsets by using monoclonal antibodies in various immunoneurological disorders. In multiple sclerosis, most studies indicated decreases of suppressor T cells and suppressor-inducer T cells in both peripheral blood and cerebrospinal fluid (CSF). In HTLV-I-associated myelopathy, our studies showed an increase of CD28-negative cytotoxic T cells in the CSF, indicating the involvement of dysfunctioned cytotoxic T cells in the spinal cord lesion formation. In myasthenia gravis, the disease-specific finding is the appearance of CD4+ CD8+ (double positive) T cells in the peripheral blood, which may be associated with thymic abnormalities. These flow cytometric studies in immunoneurological disorders thus provide an insight in the pathogenesis of immunoneurological disorders.
Kuroda
Y
Y
Department of Internal Medicine, Saga Medical School.
Matsui
M
M
D015703:Antigens, CD / Q000145:classification* / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology*
D015703:Antigens, CD