The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5.
The gene for human excitatory amino acid transporter (EAAT1) was localized to the distal region of human chromosome 5p13 by in situ hybridization of metaphase chromosome spreads. Interspecific back-cross analysis identified the mouse Eaat1 locus in a region of 5p13 homology on mouse chromosome 15. Markers that are linked with EAAT1 on both human and mouse chromosomes include the receptors for leukemia inhibitory factor, interleukin-7, and prolactin. The Eaat1 locus appears not to be linked to the epilepsy mutant stg locus, which is also on chromosome 15. The EAAT1 locus is located in a region of 5p deletions that have been associated with mental retardation and microcephaly.
Kirschner
M A
MA
Vollum Institute for Advanced Biomedical Research, Portland, Oregon.
Arriza
J L
JL
Copeland
N G
NG
Gilbert
D J
DJ
Jenkins
N A
NA
Magenis
E
E
Amara
S G
SG
D026905:Amino Acid Transport Systems; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D003433:Crosses, Genetic; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D017403:In Situ Hybridization; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008831:Microcephaly / Q000235:genetics; D008969:Molecular Sequence Data; D009115:Muridae; D013045:Species Specificity
D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D018846:Excitatory Amino Acids; D005819:Genetic Markers