The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice.
Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-delta 8-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive (+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.
Collins
D R
DR
Department of Biomedical Sciences, Marischal College, University of Aberdeen, UK.
Pertwee
R G
RG
Davies
S N
SN
D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D013759:Dronabinol / Q000031:analogs & derivatives / Q000494:pharmacology; D004558:Electric Stimulation; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D009412:Nerve Fibers / Q000187:drug effects; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D013569:Synapses / Q000502:physiology
D002186:Cannabinoids; D016194:Receptors, N-Methyl-D-Aspartate; D013759:Dronabinol; C062018:HU 211