Inhibition of myeloperoxidase release from rat polymorphonuclear leukocytes by a series of azachalcone derivatives.
A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.
Edwards
M L
ML
Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
Stemerick
D M
DM
Sabol
J S
JS
Diekema
K A
KA
Dinerstein
R J
RJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D002351:Carrageenan; D016257:Fura-2; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D015759:Ionomycin / Q000494:pharmacology; D008297:Male; D008345:Manganese / Q000378:metabolism; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D009195:Peroxidase / Q000096:biosynthesis / Q000378:metabolism*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011725:Pyridines; C090932:1-phenyl-3-(4-pyridinyl)-2-propen-1-one; D008345:Manganese; D015759:Ionomycin; D009240:N-Formylmethionine Leucyl-Phenylalanine; D002351:Carrageenan; D009195:Peroxidase; D002118:Calcium; D016257:Fura-2