title: [Studies on some derivatives of crotepoxide--an antitumor constituent of Piper futokadzura].
abstract: Through reactions of deacetylation and partial deacetylation with selected opening of epoxide ring, seven derivatives of crotepoxide (futoxide), a known antitumor constituent from Piper futokudzura, were prepared. Preliminary pharmacological tests showed that individual derivative possess significant inhibitory activity at 2 x 10(-4) mol/L to the PAF-induced platelet aggregation, while crotepoxide has no effect even at fivefold of this concentration.
authors.affiliation: Department of Chemistry, Shanghai Second Medical University.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Chen
authors.forename: P J
authors.initials: PJ
authors.lastname: Xu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D004852:Epoxy Compounds; D010975:Platelet Aggregation Inhibitors; C011828:futoxide