Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide.
The effects of long-term treatment of C57BL/6J (ob/ob) mice with a synthetic carboxylterminal sequence of human growth hormone, hGH 177-191, were investigated. Results indicate that the hGH 177-191 reduced the cumulative body weight gain, and decreased the adipose tissue mass. The lipogenesis in adipose tissues was significantly inhibited by the treatment with hGH 177-191. These findings support the suggestion that hGH 177-191 is the functional domain of hGH for the antilipogenic actions of the intact hormone both in vivo and in vitro. The hGH 177-191 peptide has the potential to be an effective compound for the treatment of human obesity and for the improvement of meat qualities in farm animals.
Natera
S H
SH
Department of Biochemistry, Monash University, Clayton, Victoria, Australia.
Jiang
W J
WJ
Ng
F M
FM
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002784:Cholesterol / Q000097:blood; D004435:Eating; D005260:Female; D013006:Growth Hormone / Q000138:chemical synthesis / Q000494:pharmacology*; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008969:Molecular Sequence Data; D009765:Obesity / Q000473:pathology / Q000503:physiopathology*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects*
D008055:Lipids; D010446:Peptide Fragments; D014280:Triglycerides; C035327:somatotropin (177-191); D013006:Growth Hormone; D002784:Cholesterol