Experimental idiopathic dilated cardiomyopathy under low-calcium condition.
Administration of long-term, low-dose Na2EDTA leads to moderate or severe thinning of the right ventricular wall with or without rupture. These morphological manifestations are known to be site-dependent on the constriction of pulmonary arteries (Yamaguchi et al. 1993a). They sometimes ensue from aneurysmal dilatation and/or plexiform-like-lesion in a pulmonary artery (Yamaguchi et al. 1993b). The present contribution reports that experimental animals who survived for a longer period, maximum for 6 months, showed dilatation of the left ventricle with a mode-rately thin ventricular wall as well as right ventricular changes, which are similar to the morphological manifestations in idiopathic dilated cardiomyopathy.
Yamaguchi
H
H
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Kaku
H
H
Onodera
T
T
Kurokawa
R
R
Morisada
M
M
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced / Q000473:pathology*; D004492:Edetic Acid; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology*; D008297:Male; D009206:Myocardium / Q000473:pathology*
D004492:Edetic Acid