title: Cluster of multiresistant Escherichia coli O78:H10 in Greater Copenhagen.
abstract: A multiresistant, lactose-negative Escherichia coli O78:H10 was isolated from 19 patients in Greater Copenhagen over a period of 8 months. At least 14 cases were community-acquired. 18 isolates originated from urine cultures and 1 from a faecal sample. 13 patients were predisposed to urinary tract infection (UTI) and 11 patients showed clinical signs of UTI. This is the first report of E. coli O78:H10 causing human disease. The cluster was probably food-borne, but the source was not identified. This cluster of identical disease associated E. coli was only uncovered because of its multiresistance and lactose-negative phenotype.
authors.affiliation: International Escherichia and Klebsiella Centre (WHO), Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Olesen
authors.forename: H J
authors.initials: HJ
authors.lastname: Kolmos
authors.forename: F
authors.initials: F
authors.lastname: Orskov
authors.forename: I
authors.initials: I
authors.lastname: Orskov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D017714:Community-Acquired Infections; D003718:Denmark / Q000453:epidemiology; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000145:classification* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012703:Serotyping; D014552:Urinary Tract Infections / Q000382:microbiology