title: Active microglia, sick astroglia and Alzheimer type dementias.
abstract: We propose that Alzheimer's disease is initiated by failure of axonal transport. After the neurodegeneration cascade is initiated, microglial and astroglial cells have major roles in directly and indirectly promoting self-sustaining neurodegeneration cycles. This hypothesis makes testable predictions and suggests logical therapies.
authors.affiliation: Department of Neural Plasticity, Instituto Cajal, C.S.I.C., Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Nieto-Sampedro
authors.forename: F
authors.initials: F
authors.lastname: Mora
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001253:Astrocytes / Q000473:pathology*; D001369:Axons / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D006801:Humans; D017628:Microglia / Q000473:pathology*; D009410:Nerve Degeneration / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides