[Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro].
The effect of mangiferin, a tetrahydroxy pyrrolidone saponin extracted from the leaves of mango (Mangifera indica), against herpes simplex virus type 2 (HSV-2) in vitro was studied. The 50% effective concentration (EC50) of it against HSV-2 plaque formation in HeLa cells was 111.7 micrograms.ml-1, and the concentrations of 33 and 80 micrograms.ml-1 reduced the virus replicative yields by 90% (EC90) and 99% (EC99), respectively. The therapeutic index (IC50/EC50) was 8.1. Mangiferin did not directly inactivate HSV-2. The results of the drug addition and removal tests suggest that mangiferin inhibits the late event in HSV-2 replication.
Zhu
X M
XM
Department of Microbiology, Hengyang Medical College, China.
Song
J X
JX
Huang
Z Z
ZZ
Wu
Y M
YM
Yu
M J
MJ
D000998:Antiviral Agents / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D014779:Virus Replication / Q000187:drug effects*; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D000998:Antiviral Agents; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin