title: Age-related changes in transcriptional and posttranscriptional regulation of the dopaminergic system.
abstract: Loss of striatal dopamine receptors is a major cause of decreased motor control and a robust biomarker of aging. Mechanisms of receptor loss include both neuronal death and decreased expression of receptor genes at the transcriptional and translational levels.
authors.affiliation: Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
authors.forename: G S
authors.initials: GS
authors.lastname: Roth
authors.forename: J A
authors.initials: JA
authors.lastname: Joseph
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; D011954:Receptors, Dopamine