[Combined detoxification and immunocorrective therapy in patients with peritonitis].
The authors examined 48 patients with peritonitis (20 with the generalized and 28 with the localized form). The content of T-lymphocytes, theophylline-resistant and theophylline-sensitive T-lymphocytes, leukocyte chemotaxic activity, and the lymphocyte ATP content were studied. It was found that the state of the immune system in the early postoperative period allows the severity of the disease and its outcome to be prognosticated. A sharp decrease in the T-lymphocyte content and decrease of the amount of ATP in the lymphocytes in stable reduction of chemotaxic activity is an unfavorable prognostic sign. Introduction of indirect electrochemical oxidation with a sodium hypochlorite solution into the complex of intensive therapy produces, in addition to a marked detoxification effect, a stabilizing effect on metabolic processes in the lymphocytes and activates the cellular link of immunity. Combined immunocorrection with the agents tactivin and leukinferon possesses a high potential of an immunobiological effect and can be recommended for correction of severe secondary immunodeficiency in patients with generalized peritonitis.
Shkrob
L O
LO
Fedotov
P A
PA
Ermakova
N G
NG
D000255:Adenosine Triphosphate / Q000032:analysis; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D003131:Combined Modality Therapy; D016207:Cytokines / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D010455:Peptides / Q000627:therapeutic use*; D010538:Peritonitis / Q000276:immunology / Q000628:therapy*; D011182:Postoperative Care; D011379:Prognosis; D012720:Severity of Illness Index; D012973:Sodium Hypochlorite / Q000627:therapeutic use*; D016060:Sorption Detoxification; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D010455:Peptides; D013949:Thymus Extracts; C062252:leukinferon; C036191:T-activin; D000255:Adenosine Triphosphate; D012973:Sodium Hypochlorite
Kompleksnaia detoksikatsionnaia i immunokorrigiruiushchaia terapiia u bolńykh s peritonitom.