Effects of a long-term transfusion regimen on sickle cell-related illnesses.
The efficacy of a long-term transfusion regimen in preventing sickle cell disease complications is unknown. We examined 17 patients before, during, and after transfusion for cerebral vascular accident and vaso-occlusive crisis. Total hospitalization rate, as well as admissions for vaso-occlusive crisis, cases of acute chest syndrome, and bacterial infections decreased while patients were on a transfusion regimen.
Styles
L A
LA
Department of Hematology/Oncology, Children's Hospital Oakland, California 94609.
Vichinsky
E
E
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D001803:Blood Transfusion; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002637:Chest Pain / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome; D014777:Virus Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*