Mammalian exchangers and co-transporters.
In the past year, novel mammalian exchanger and co-transporter isoforms have been characterized. Specialized subdomains within these oligomeric transporters have been shown to be involved in biosynthesis, targeting, transport and regulation. Progress on the structural front has been limited due to the lack of high-resolution structures, but transport mutants responsible for disease states continue to be identified.
Reithmeier
R A
RA
Department of Medicine, University of Toronto, Canada.
D000818:Animals; D017920:Antiporters / Q000235:genetics / Q000502:physiology*; D001639:Bicarbonates / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology; D027963:Chloride-Bicarbonate Antiporters; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D012964:Sodium / Q000378:metabolism; D019831:Sodium-Calcium Exchanger; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology
D017920:Antiporters; D001639:Bicarbonates; D002352:Carrier Proteins; D027963:Chloride-Bicarbonate Antiporters; D002712:Chlorides; D019831:Sodium-Calcium Exchanger; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium; D002118:Calcium