[Cardiac arrhythmia with oral oxamniquine use in the schistosomiasis mansoni treatment].
The authors report a case of a patient with schistosomiasis (S. mansoni) treated with one single dose (15 mg/kg/BWT) of oral oxamniquine who presented Mobitz type I second-degree AV block and sinus arrest with ventricular escape as a side-effect. They conclude that in spite of the safety and good activity of oxamniquine it may be a determinant of cardiotoxicity.
Guitti
J C
JC
Departamento Materno-Infantil e Saúde-Comunitária, Universidade Estadual de Londrina, Paraná, Brasil.
Gordan
L N
LN
Baldy
J L
JL
D000284:Administration, Oral; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002648:Child; D004562:Electrocardiography; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D008297:Male; D010073:Oxamniquine / Q000008:administration & dosage / Q000009:adverse effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
D010073:Oxamniquine
Arritmia cardíaca com uso de oxamniquine oral no tratamento de esquistossomose mansônica.