title: Meperidine neurotoxicity after organ transplantation.
abstract: Meperidine neurotoxicity, characterized by recurrent convulsions, myoclonus, and asterixis, was diagnosed in an organ transplant recipient. Aside from cyclosporine toxicity, the literature regarding neurologic complications of transplantation contains limited reference to the neurotoxicity of therapy. The case reported illustrates how pharmacokinetic factors might render transplant patients particularly vulnerable to the neurotoxic side effects of certain medications, such as meperidine.
authors.affiliation: Shands Hospital, University of Florida School of Medicine, Gainesville.
authors.forename: J C
authors.initials: JC
authors.lastname: Adair
authors.forename: R L
authors.initials: RL
authors.lastname: Gilmore
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008614:Meperidine / Q000009:adverse effects* / Q000097:blood; D016035:Pancreas Transplantation; D010195:Pancreatitis / Q000188:drug therapy; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D008614:Meperidine