title: Asymmetrical changes in the choline acetyltransferase activity in the preoptic-anterior hypothalamic area during the oestrous cycle of the rat.
abstract: There is evidence that the cholinergic system modulates, in a circadian and asymmetric way, the neural activity involved in the regulation of ovulation. In the present study we measured choline acetyltransferase (ChAT) activity during the oestrous cycle in both sides of the preoptic-anterior hypothalamic area (POA-AHA) of the rat. The right side of POA-AHA showed significant changes in ChAT activity during the oestrous cycle. The activity of the enzyme was higher in the right side on the day of oestrous (47.3 +/- 3.2 nmol mg-1 protein 1 h-1 vs 25.8 +/- 2.4, p < 0.05), whilst on the second day of dioestrous the activity was higher in the left one (30.6 +/- 3.4 vs 20.0 +/- 1.5). The differences in the activity of ChAT observed support the idea of the existence of asymmetry in the POA-AHA cholinergic system which varies during the oestrous cycle.
authors.affiliation: Laboratorio de Neuroendocrinología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, México D.F.
authors.forename: M A
authors.initials: MA
authors.lastname: Sánchez
authors.forename: J C
authors.initials: JC
authors.lastname: López-García
authors.forename: M E
authors.initials: ME
authors.lastname: Cruz
authors.forename: R
authors.initials: R
authors.lastname: Tapi
authors.forename: R
authors.initials: R
authors.lastname: Domínguez
mesh_terms: D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004971:Estrus / Q000502:physiology*; D005260:Female; D011301:Preoptic Area / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002795:Choline O-Acetyltransferase