[Effects of 6,7-dimethoxycoumarin on experimental arrhythmia].
By using the arrhythmic animal models, the effect of 6,7-dimethoxycoumarin (DMOC) on arrhythmia was investigated. The arrhythmia in anaesthetized rat were induced by iv aconitine 20 micrograms.kg-1 or CaCl2 5 mg.kg-1. The arrhythmia in anesthetized guinea pigs was induced by iv ouabain 3.6 micrograms.kg-1.min-1. Procainamide (PA) was used as a positive control. DMOC (33-500 mg.kg-1, ig) and PA (100-800 mg.kg-1, ig) in anaesthetized rats could delay the time of onset of arrhythmia induced by aconitine. The ED50 of DMOC and PA for postponing the occurrence of ventricular extrasystole (VE) were 88 mg.kg-1 (95% confidence interval was 43-165 mg.kg-1) and 183 mg.kg-1 (95% confidence interval was 109-304 mg.kg-1), respectively. The results suggested that the anti-arrhythmia potency of DMOC was higher than that of PA (P < 0.01).
Du
G Y
GY
Department of Pharmacology, Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Ye
W H
WH
Lü
F
F
Jing
H D
HD
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D003374:Coumarins / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D010042:Ouabain; D011342:Procainamide / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000889:Anti-Arrhythmia Agents; D003374:Coumarins; D010042:Ouabain; C018145:scoparone; D011342:Procainamide; D000157:Aconitine