Molecular characterization of the Nur77 orphan steroid receptor in apoptosis.
One of the in vitro model of programmed cell death is T cell receptor (TCR)-mediated apoptosis of immature T cells and T cell hybridomas. This form of apoptosis requires newly gene synthesis and may relate to negative selection during T cell development. Recently, an orphan steroid receptor Nur77 was found to be induced during TCR-mediated apoptosis. When introduced into T cells, a dominant negative or antisense Nur77 construct can block the apoptosis process. Various inhibitors of TCR-mediated apoptosis, including cyclosporin A down-regulate the Nur77 DNA binding activity. Thus, the Nur77 protein family may play a crucial role during T cell apoptosis.
Winoto
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Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200.
D000818:Animals; D017209:Apoptosis; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011948:Receptors, Antigen, T-Cell; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors