Ovarian cyst formation in two pre-menopausal patients treated with tamoxifen for breast cancer.
Pre-menopausal tamoxifen treatment causes hyperoestrogen production and ovarian cyst formation. Two pre-menopausal breast cancer patients who were treated with tamoxifen developed both permanent supraphysiological oestrogen concentration and ovarian cysts. Serum oestrogen decreased to post-menopausal concentrations and ovarian cysts completely resolved during and following simultaneous treatment with tamoxifen and gonadotrophin-releasing hormone agonist (GnRHa). In pre-menopausal breast cancer patients, GnRHa may prevent possible side-effects of tamoxifen, such as ovarian cysts and supraphysiological oestrogen production.
Shulman
A
A
Department of Obstetrics and Gynaecology, Sapir Medical Centre, Kfar Saba, Israel.
Cohen
I
I
Altaras
M M
MM
Maymon
R
R
Ben-Nun
I
I
Tepper
R
R
Beyth
Y
Y
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D010048:Ovarian Cysts / Q000139:chemically induced* / Q000517:prevention & control; D017697:Premenopause; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use
D017329:Triptorelin Pamoate; D013629:Tamoxifen; D004958:Estradiol