Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases.
Panaxynol is a polyacetylene compound isolated from commonly used oriental medicines, and its effects on various cyclooxygenases and lipoxygenases were investigated. The compound had only a marginal effect on cyclooxygenase activities (IC50 values >> 100 microM), but inhibited lipoxygenases; 5-lipoxygenase (IC50, 2 microM), two isoforms of 12-lipoxygenase (leukocyte-type, 1 microM; platelet-type, 67 microM) and 15-lipoxygenase (4 microM). Thus, panaxynol inhibited leukocyte-type 12-lipoxygenase much more effectively than platelet-type 12-lipoxygenase. Falcarindiol, an analogue of panaxynol, inhibited these lipoxygenases with higher IC50 values than panaxynol. These compounds could provide a clue to develop a selective inhibitor of one isoform of 12-lipoxygenase.
Alanko
J
J
Department of Biochemistry, Tokushima University, School of Medicine, Japan.
Kurahashi
Y
Y
Yoshimoto
T
T
Yamamoto
S
S
Baba
K
K
D000480:Alkynes; D000818:Animals; D053280:Diynes; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D012756:Sheep
D000480:Alkynes; D053280:Diynes; D004365:Drugs, Chinese Herbal; D005233:Fatty Alcohols; D016859:Lipoxygenase Inhibitors; C018541:falcarinol