title: New material for low-cost intraocular lenses.
abstract: A UV-hardening lacquer material based on polyurethane, used in Philips compact disc lens systems, was tested as suitable material for low-cost intraocular lenses (IOLs). A slightly changed composition (code number I-0.5A) came out as the best and was subsequently tested, with reference to poly(methyl methacrylate) (PMMA), as a 'lobster-claw' lens in Hollander rabbit eyes for a period of 24 wk. No carcinogenic effects were found, while only minor vascularization of the cornea at the incision area occurred. The in vitro biocompatibility tests of the material were positive. Scanning electron microscopy images of the IOLs at 2, 6, 12 and 24 wk postoperative showed portions of an acellular membrane, multinuclear giant cells which hyalinize and stay as pigmented plaques, microphages and fibroblasts with fibrillar strands, long pseudopodia, and broad microplicea. The chosen UV lacquer showed a foreign body reaction and properties comparable with PMMA, and is suitable for manufacturing low-cost IOLs.
authors.affiliation: Laboratory of Histology and Cell Biology, University of Groningen, The Netherlands.
authors.forename: W L
authors.initials: WL
authors.lastname: Jongebloed
authors.forename: G
authors.initials: G
authors.lastname: van der Veen
authors.forename: D
authors.initials: D
authors.lastname: Kalicharan
authors.forename: M V
authors.initials: MV
authors.lastname: van Andel
authors.forename: G
authors.initials: G
authors.lastname: Bartman
authors.forename: J G
authors.initials: JG
authors.lastname: Worst
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D005129:Eye Foreign Bodies / Q000473:pathology; D007910:Lenses, Intraocular; D008422:Materials Testing; D008768:Methylmethacrylates / Q000009:adverse effects; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D008768:Methylmethacrylates; D011140:Polyurethanes