Hypercalcaemia in B cell chronic lymphocytic leukaemia.
Hypercalcaemia is common in some lymphoproliferative disorders such as myeloma or T-cell leukaemia-lymphoma, but is rarely described in B cell chronic lymphocytic leukaemia (BCLL). We report the case of a patient with BCLL, hypercalcaemia and osteolytic bone lesions. Parathyroid hormone-related protein (PTHrP) mRNA was identified by Northern blot analysis of liver, spleen and lymph node tumour samples. Serum levels of tumour necrosis factor alpha (TNF alpha) were increased.
Fain
O
O
Department of Internal Medicine, Haematology and Pathology, Jean Verdier Hospital, Bondy, France.
el M'Selmi
A
A
Dosquet
C
C
Meseure
D
D
Lejeune
F
F
Garel
J M
JM
Thomas
M
M
D015152:Blotting, Northern; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D014409:Tumor Necrosis Factor-alpha