[Intraarterial chemotherapy for metastatic renal cell carcinomas: combination with MDR-overcoming agents].
We analyzed the sensitizing activity of five agents, which have been assumed to be MDR-overcoming drugs, in two human renal cell carcinoma cell lines expressing the MDR1 gene at high levels. In addition, we studied the sensitizing activity of cepharanthin, an MDR-overcoming agents, to vinblastine, adriamycin, epirubicin, cisplatin, mitomycin C and etoposide. Based on the results, we treated 6 patients with metastatic renal cell carcinomas (4: bones, 2: contralateral kidneys) by intraarterial injection of vinblastine and adriamycin (or epirubicin) in combination with cepharanthin. Two of the 4 bone metastasis cases responded markedly to the treatment. Renal tubular impairment was observed in one patient who was treated for the contralateral kidney metastasis.
Kakehi
Y
Y
Department of Urology, Kyoto University Faculty of Medicine.
Yoshida
O
O
Segawa
T
T
Kanematsu
A
A
Hiura
M
M
Shichiri
Y
Y
Arai
Y
Y
D000470:Alkaloids / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary*; D004317:Doxorubicin / Q000008:administration & dosage; D018432:Drug Resistance, Multiple / Q000235:genetics*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D014747:Vinblastine / Q000008:administration & dosage; D052117:Benzodioxoles
D000470:Alkaloids; D044182:Benzylisoquinolines; D004317:Doxorubicin; D014747:Vinblastine; C006947:cepharanthine; D052117:Benzodioxoles