title: Cytokines stimulate lipid membrane peroxidation of human sperm.
abstract: Reactive oxygen species production has been demonstrated to impair sperm function. We have noted the potential for the cytokines IL-1 alpha, IL-1 beta, and TNF alpha to stimulate reactive oxygen species production by fertile donor sperm at levels that are consistent with the levels of IL-1 occurring in human seminal plasma. Reactive oxygen species-related sperm membrane peroxidation may be one mechanism by which cytokines can exert a detrimental effect on male fertility. This study suggests a new mechanism by which cell-mediated immunological male infertility may occur.
authors.affiliation: Department of Surgery, University of Connecticut Health Center, Farmington 06030-3955.
authors.forename: J P
authors.initials: JP
authors.lastname: Buch
authors.forename: T F
authors.initials: TF
authors.lastname: Kolon
authors.forename: N
authors.initials: N
authors.lastname: Maulik
authors.forename: D L
authors.initials: DL
authors.lastname: Kreutzer
authors.forename: D K
authors.initials: DK
authors.lastname: Das
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D016207:Cytokines / Q000494:pharmacology*; D006801:Humans; D007378:Interleukins / Q000494:pharmacology; D050356:Lipid Metabolism; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010545:Peroxides / Q000378:metabolism*; D013094:Spermatozoa / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D016207:Cytokines; D007378:Interleukins; D010545:Peroxides; D014409:Tumor Necrosis Factor-alpha; D009240:N-Formylmethionine Leucyl-Phenylalanine; D013755:Tetradecanoylphorbol Acetate