title: Bactericidal activities of DU-6859a and clinafloxacin (CI-960) against staphylococci.
abstract: Time killing curves were calculated at concentrations of 2 and 8 times the MICs of DU-6859a and clinafloxacin against six isolates of Staphylococcus aureus. Both quinolones produced a decrease in the log10 CFU per milliliter of > or = 3 within 3 h at 2 and 8 times the MIC for the ciprofloxacin-susceptible isolates and at 8 times the MIC for the ciprofloxacin-resistant isolates; however, only 8 times the MIC of DU-6859a consistently prevented regrowth of all isolates after 24 h of incubation.
authors.affiliation: Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195-5140.
authors.forename: G J
authors.initials: GJ
authors.lastname: Forstall
authors.forename: C C
authors.initials: CC
authors.lastname: Knapp
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D013141:Spiro Compounds / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D013141:Spiro Compounds; C057477:clinafloxacin; C076246:sitafloxacin