title: Progressive osseous heteroplasia: a case report.
abstract: We report the case of a young female who, from infancy, suffered extensive, progressive, heterotopic ossification of her left lower limb. Heterotopic ossification, which was largely but not exclusively intramembranous in type, was most marked in subcutaneous fat but was also noted in muscle and deep connective tissue. The spectrum of changes noted suggests that this congenital disorder of soft tissues is similar to that recently described as progressive osseous heteroplasia.
authors.affiliation: Department of Pathology, Nuffield Orthopaedic Centre, Oxford, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
authors.forename: M K
authors.initials: MK
authors.lastname: Benson
authors.forename: B P
authors.initials: BP
authors.lastname: Brenton
authors.forename: R
authors.initials: R
authors.lastname: Smith
mesh_terms: D000005:Abdomen / Q000473:pathology; D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D000671:Amputation, Surgical; D001846:Bone Development / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D003238:Connective Tissue / Q000473:pathology*; D005260:Female; D006615:Hip / Q000473:pathology; D006801:Humans; D007866:Leg / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D018482:Muscle, Skeletal / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000151:congenital / Q000473:pathology* / Q000601:surgery; D010146:Pain; D011859:Radiography; D013848:Thigh / Q000473:pathology