title: Genetic markers in hypercholesterolemic and normocholesterolemic Czech children.
abstract: The genetic background of polygenic hypercholesterolemia was studied in hypercholesterolemic children consuming a diet identical to control individuals with low cholesterol concentrations. Significantly higher frequencies of "disadvantage" alleles, usually combined with a higher LDL cholesterol, were found in hypercholesterolemic individuals when polymorphisms in apolipoprotein E, apolipoprotein B--XbaI and LDL receptor--PvuII were studied.
authors.affiliation: Institute for Clinical and Experimental Medicine, Laboratory for Atherosclerosis Research, Prague, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Poledne
authors.forename: J
authors.initials: J
authors.lastname: Hubácek
authors.forename: Z
authors.initials: Z
authors.lastname: Písa
authors.forename: H
authors.initials: H
authors.lastname: Pistulková
authors.forename: Z
authors.initials: Z
authors.lastname: Valenta
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D002648:Child; D002874:Chromosome Mapping; D003604:Czechoslovakia; D005819:Genetic Markers; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000235:genetics; D012016:Reference Values
chemical_list: D001055:Apolipoproteins B; D001057:Apolipoproteins E; D005819:Genetic Markers; D011973:Receptors, LDL