[Combined strategy of cancerous cells: fat and protein metabolism. Conclusions (3rd of 3 parts)].
The metabolic and biochemical program of neoplastic cells regarding carbohydrate metabolism can be extend to the rest of the metabolism. This gives a rational idea of the global strategy and thermodynamic advantages of malignant cells and of tumors in general as related to the host. A comprehensive, metaenzymatic and transbiochemical approach allows to understand some of the reasons for the limitations found along the last decades by the different chemotherapeutic attempts directed against particular enzymes overexpressed in tumor cells. This indicates that a new vision of the whole problem is preceptive. The overwhelming effects of the hydrogen ion at multiple levels indicates that an initial approach based upon this unifying principle and universal regulatory parameter may provide the initial codes, hints and hunches, of a new synthetic and unitive biological, biomedical and biophysical scientific paradigm. Initially, it already offers the possibility of a new multidisciplinary approach to the prevention and treatment of tumors such as cervical intraepitelial neoplasia.
Harguindey
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Servicio de Oncología, Clínica La Esperanza, Vitoria.
D050260:Carbohydrate Metabolism; D005223:Fats / Q000378:metabolism*; D006801:Humans; D007659:Ketones / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D005223:Fats; D007659:Ketones; D011506:Proteins
Estrategia unitiva de las células cancerosas: metabolismo graso y proteínico. Conclusiones (tercera de tres partes).