Protective immunity against multiple challenges of Brugia pahangi in Mongolian gerbils induced by drug-abbreviated infection.
Protective immunity against multiple challenge infections was examined in Mongolian gerbils after a drug-abbreviated infection with Brugia pahangi. The gerbils treated with mebendazole (MBZ) during the late prepatent period (7-9 weeks of postinfection) were challenged with 5 inoculations of 50 infective larvae of B. pahangi at 4-week intervals. The worm burden was significantly reduced 68.6% (19.0 in average number) to that of controls (60.6) and was accompanied with enhanced eosinophil responses 1 week after each challenge. MBZ-treated gerbils suppressed microfilaremia almost completely after the challenge infections.
Horii
Y
Y
Department of Veterinary Internal Medicine, Faculty of Agriculture, Miyazaki University, Japan.
Makimura
S
S
D000818:Animals; D017179:Brugia pahangi / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D005368:Filariasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D005849:Gerbillinae / Q000276:immunology*; D007114:Immunization / Q000379:methods / Q000662:veterinary; D007814:Larva / Q000472:pathogenicity; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D012376:Rodent Diseases / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control
D008463:Mebendazole