title: Myopathy with ragged red fibres following renal transplantation: possible role of cyclosporin-induced hypomagnesaemia.
abstract: A 65-year-old man developed a painless proximal myopathy 7 years after commencing cyclosporin therapy following a successful cadaveric renal transplant. Muscle histology showed ragged red fibres and biochemical studies suggested mitochondrial dysfunction. The possible pathogenesis of this mitochondrial myopathy, particularly its relationship to cyclosporin-induced hypomagnesaemia, is discussed.
authors.affiliation: Midland Centre for Neurosurgery and Neurology, Warley, West Midlands, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Larner
authors.forename: S G
authors.initials: SG
authors.lastname: Sturman
authors.forename: J B
authors.initials: JB
authors.lastname: Hawkins
authors.forename: M
authors.initials: M
authors.lastname: Anderson
mesh_terms: D000368:Aged; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D008275:Magnesium Deficiency / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008931:Mitochondria, Muscle / Q000502:physiology / Q000648:ultrastructure; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000209:etiology / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology*
chemical_list: D016572:Cyclosporine