[Constitutional translocation t(1;6) and Burkitt's lymphoma].
BACKGROUND
The relationship between constitutional chromosome aberrations and a predisposition to malignancy has already been established.


METHODS
A 4 year-old boy was admitted suffering from abdominal mass. Biopsies of the tumor and bone marrow showed a stage IV Burkitt's lymphoma. Karyotype showed a constitutional t(1;6)(p36;q22) in initial bone marrow samples and peripheral lymphocytes. No classic Burkitt's type translocation was demonstrated in the malignant bone marrow cells.


CONCLUSIONS
Our case is similar to four other reported cases. The break-points 1p36 and 6q22 seem to be involved in several malignant tumors, especially lymphomas.
Berger
C
C
Département de pédiatrie, centre Léon-Bérard, Lyon.
Frappaz
D
D
Bouffet
E
E
Sobol
H
H
Charra
C
C
Philip
T
T
Brunat-Mentigny
M
M
Bertheas
M F
MF
D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D014178:Translocation, Genetic
Translocation constitutionnelle t(1;6) et lymphome de Burkitt.