PS-990, a novel neuritogenic compound from Acremonium sp.
A novel compound, PS-990, which induces differentiation of neuroblastoma cells, was isolated from the culture broth of a fungus, Acremonium sp. KY12702. PS-990 inhibited brain calcium calmodulin-dependent cyclic nucleotide phosphodiesterase with an IC50 value of 3 micrograms/ml, and markedly induced neurite extension of mouse neuroblastoma, Neuro2A, at concentrations ranging from 10 to 30 micrograms ml.
Toki
S
S
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., Japan.
Ando
K
K
Yoshida
M
M
Matsuda
Y
Y
D000164:Acremonium / Q000145:classification / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D005285:Fermentation; D062385:Hydroxybenzoates / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D016501:Neurites / Q000187:drug effects*; D009447:Neuroblastoma / Q000473:pathology; D010726:Phosphodiesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D062385:Hydroxybenzoates; D010726:Phosphodiesterase Inhibitors; C091109:PS 990