Influence of protein calorie malnutrition and fasting on the activities of delta-aminolevulinic acid dehydratase and porphobilinogen deaminase in rats.
Rats were fed a restricted standard diet (6-8 g daily) for 4 weeks. The erythrocyte activity of delta-aminolevulinic acid dehydratase showed a very expressed decrease (7.9 times) and its hepatic activity diminished more than twice. Porphobilinogen deaminase activity was reduced by 40% and 17% respectively. After a 3-day total food deprivation delta-aminolevulinic acid dehydratase activity remained unchanged in red blood cells, but an increase by 52% was found in the liver. The erythrocyte activity of porphobilinogen deaminase was reduced by 42% and its hepatic activity--by 16%.
Adjarov
D G
DG
Centre of Hygiene, Ecology and Nutrition, Sofia, Bulgaria.
Naydenova
E N
EN
Kerimova
M A
MA
Pentieva
K D
KD
Ivanova
L B
LB
Ivanova
A V
AV
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology; D005215:Fasting / Q000378:metabolism*; D005260:Female; D011163:Hydroxymethylbilane Synthase / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D000623:Porphobilinogen Synthase / Q000097:blood / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
D011163:Hydroxymethylbilane Synthase; D000623:Porphobilinogen Synthase