Development of the spinal nerves in the mouse with special reference to innervation of the axial musculature.
Development of the mouse spinal nerves was studied. On E11 (11th day of gestation), the primitive spinal nerve fascicle extended ventrally in the anterior half of the sclerotome. Spinal nerves in the forelimb region united with each other to form the primitive brachial plexus. Their terminal segment was covered by a peculiar cell mass. On E12, five primary branches developed along the primitive spinal nerve trunk. The ramus dorsalis was originally a cutaneous nerve, supplying two series of branches to the skin of the back. The medial series was derived from the dorsal ramus of C2-C8, and the lateral series from C8 and the more caudal dorsal rami. Nerves of the former series took the presegmental course through the intermyotomic space, while those of the latter the postsegmental course. The ramus cutaneous lateralis was a nerve that took the presegmental course to become cutaneous. The ramus intercostalis externus was a muscle branch whose distribution was restricted within the segment. The ramus anterior was a muscle branch from the end of the primitive spinal nerve trunk. The ramus visceralis connected a thoracic nerve with the para-aortic sympathetic cell cord. On E13-16 the ramus anterior secondarily gave off a cutaneous branch (ramus cutaneous anterior). The ramus intercostalis externus extended ventrally deep to the intercostalis externus muscle, crossing just caudal to the ramus cutaneous lateralis that secondarily gave off branches to the obliquus externus abdominis muscle.
Nakao
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Department of Anatomy, Akita University School of Medicine, Japan.
Ishizawa
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D000005:Abdomen; D000818:Animals; D001415:Back; D004622:Embryo, Mammalian / Q000294:innervation; D005260:Female; D051379:Mice; D008817:Mice, Mutant Strains / Q000196:embryology*; D008854:Microscopy, Electron; D009132:Muscles / Q000294:innervation*; D011247:Pregnancy; D013127:Spinal Nerves / Q000033:anatomy & histology / Q000196:embryology*; D013900:Thoracic Nerves / Q000033:anatomy & histology / Q000196:embryology