Thyrotropin-releasing hormone (TRH) inhibits vasopressin release from hypothalamo-neurohypophysial system of rats drinking hypertonic saline.
Rats drinking ad libitum tap water or hypertonic (i.e. 2%) sodium chloride solution were given intracerebroventricularly (i.c.v.) for three days, thyrotropin-releasing hormone (TRH) in a daily dose of 200 ng dissolved in 10 microliters of 0.9% sodium chloride. Treatment with TRH resulted in significantly increased hypothalamic vasopressin content in both euhydrated (i.e. given tap water ad libitum) and salt-loaded rats. In rats given hypertonic saline, neurohypophysial vasopressin content increased. Plasma vasopressin concentration was distinctly diminished under TRH treatment, the respective difference being significant, however, barely in salt-loaded rats. The present data suggest that TRH may be involved in some regulatory processes related to vasopressin biosynthesis and release from the rat hypothalamo-neurohypophysial system.
Ciosek
J
J
Department of Pathophysiology, University School of Medicine, Lodz, Poland.
Stempniak
B
B
Orlowska-Majdak
M
M
D000284:Administration, Oral; D000818:Animals; D004326:Drinking; D007030:Hypothalamo-Hypophyseal System / Q000737:chemistry / Q000378:metabolism*; D007031:Hypothalamus / Q000737:chemistry; D007276:Injections, Intraventricular; D008297:Male; D010902:Pituitary Gland / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D014667:Vasopressins / Q000032:analysis / Q000097:blood / Q000378:metabolism*
D012462:Saline Solution, Hypertonic; D014667:Vasopressins; D013973:Thyrotropin-Releasing Hormone