Neural transplantation, trophic factors and Parkinson's disease.
Part 1 of this update on new restorative therapeutic strategies against Parkinsons's disease focuses on transplantation of dopamine-secreting tissue. Special emphasis is put on clinical trials with fetal mesencephalic cells. Problems and potential alternative approaches are discussed. Part 2 emphasizes progress in the related field of neurotrophic factors for dopaminergic midbrain neurons.
Kupsch
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A
Klinikum Grosshadern, Neurological Unit, Ludwig-Maximilians-University, München, FRG.
Oertel
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WH
D000313:Adrenal Medulla / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D016380:Brain Tissue Transplantation; D004298:Dopamine / Q000378:metabolism; D016332:Fetal Tissue Transplantation; D006801:Humans; D008636:Mesencephalon / Q000378:metabolism / Q000637:transplantation*; D009414:Nerve Growth Factors / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery*
D009414:Nerve Growth Factors; D004298:Dopamine