title: [In vivo study of the antilipoperoxidant effect of 3',5,7-trihydroxy-4'-methoxy flavone 7 rutinoside].
abstract: In 3-month-old Wistar rats carrageenan and CCl4 injected intraperitoneally induce an acute phase reaction which is characterized by a marked increase in alpha 1, alpha 2, beta serum globulins. This reaction corresponds to a large increase in these globulins in the first case and a smaller one in the second. A lipoperoxidant effect is demonstrated by the serum lipoprotein mobility as the lipoperoxidation index (in MDA units) or the decrease in serum vitamin A and E concentrations. This effect is also greater in the first case than in the second one. In the same way the lipoperoxidant effect is shown in liver microsomes but with a lower amplitude in the first case than in the second one. The treatment of rats by intraperitoneal injection of diosmine (150 mg/kg per week) during the 8 weeks which precede the injection of carrageenan or CCl4 results in: i) a marked decrease in the acute-phase reaction and a lower one in the lipoperoxidant effect, in serum; ii) a decrease in the CCl4 induced lipoperoxidant effect in liver microsomes. It may be concluded that diosmine, not injected at the same time as carrageenan or CCl4, but during the previous 8 weeks is sufficiently well distributed in the whole body to produce a marked inhibition of the acute phase reaction and a perceptible effect on lipoperoxidation. It may be considered an effective complement to the natural antioxidant defences of the organism (vitamins A and E).
authors.affiliation: Laboratoire de biochimie médicale A, université de Bordeaux II, France.
authors.forename: M
authors.initials: M
authors.lastname: Freneix-Clerc
authors.forename: M F
authors.initials: MF
authors.lastname: Dumon
authors.forename: M A
authors.initials: MA
authors.lastname: Carbonneau
authors.forename: M J
authors.initials: MJ
authors.lastname: Thomas
authors.forename: E
authors.initials: E
authors.lastname: Peuchant
authors.forename: L
authors.initials: L
authors.lastname: Dubourg
authors.forename: A M
authors.initials: AM
authors.lastname: Melin
authors.forename: A
authors.initials: A
authors.lastname: Perromat
authors.forename: M
authors.initials: M
authors.lastname: Clerc
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000139:chemically induced; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D004145:Diosmin / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008054:Lipid Peroxides; D004145:Diosmin; D002351:Carrageenan; D002251:Carbon Tetrachloride
vernacular_title: Etude in vivo de l'effet antilipoperoxydant du 7 rutinoside de la 3',5,7-trihydroxy-4'-méthoxy flavone.