Developmental changes of pyroglutamate-peptidase I activity in several regions of the female and the male rat brain.
In this work, we have described decreases of pGlu-peptidase I activity, detected using pGlu-beta-naphtylamide as substrate, from 9 to the 20 days after birth in five brain areas. In addition, we have found sexual differences in the enzyme activity in the hypothalamic-pituitary axis in all ages investigated. pGlu-peptidase cleaves the pGlu-aminoacid bond of several neuropeptides such as thyroliberin, luliberin and neurotensin. The decrease in the activity of pGlu-peptidase coincidents with the increases observed in brain thyroliberin concentration and the decreases in His-Pro diketopiperazine. It is suggested that this enzyme could play a part in the normal development of the rat brain.
De Gandarias
J M
JM
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Irazusta
J
J
Fernandez
D
D
Varona
A
A
Casis
L
L
D000367:Age Factors; D000818:Animals; D005260:Female; D005625:Frontal Lobe / Q000201:enzymology / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000201:enzymology* / Q000502:physiology*; D008297:Male; D009496:Neurotensin / Q000378:metabolism; D009778:Occipital Lobe / Q000201:enzymology / Q000502:physiology; D010296:Parietal Lobe / Q000201:enzymology / Q000502:physiology; D010902:Pituitary Gland / Q000201:enzymology / Q000502:physiology; D011751:Pyroglutamyl-Peptidase I / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000502:physiology*; D012737:Sex Factors; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism
D007987:Gonadotropin-Releasing Hormone; D009496:Neurotensin; D013973:Thyrotropin-Releasing Hormone; D011751:Pyroglutamyl-Peptidase I