title: Statistical significance of amino acid sequence similarity in type II DNA methyltransferases.
abstract: The statistical significance of amino acid sequence similarities previously observed in type II DNA methyltransferases has been investigated. It is shown: (1) that the intramolecular similarities observed among various type II Mtases are not statistically significant and thus can not be used to support a gene duplication model; (2) that the intermolecular similarities observed in a peptide in various type II adenine methylases are statistically confirmed; (3) that the similarities observed between MutH and these proteins for this peptide are not statistically significant and therefore cannot be used to propose a functional role in DNA recognition for this peptide.
authors.affiliation: Département de Biologie Cellulaire et Moléculaire, Centre d'Etudes de Saclay, Gif-sur-Yvette, France.
authors.forename: J B
authors.initials: JB
authors.lastname: Guyot
authors.forename: B
authors.initials: B
authors.lastname: Caudron
mesh_terms: D000595:Amino Acid Sequence; D003627:Data Interpretation, Statistical; D008969:Molecular Sequence Data; D005810:Multigene Family; D011497:Protein O-Methyltransferase / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D011497:Protein O-Methyltransferase