Neonatal depression after a protamine sulfate injection. A case report.
The intravenous administration of protamine sulfate in adults has been associated with acute hypotension, bradycardia and anaphylactoid reactions. However, no reports of its use in pregnancy have been available before. We describe a case of severe neonatal depression following maternal protamine sulfate injection immediately prior to delivery.
Wittmaack
F M
FM
Department of Obstetrics and Gynecology, University of Wisconsin, Madison.
Greer
F R
FR
FitzSimmons
J
J
D000293:Adolescent; D016887:Cardiopulmonary Resuscitation; D005260:Female; D005268:Femoral Vein; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D009270:Naloxone / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011479:Protamines / Q000009:adverse effects*; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000628:therapy; D013927:Thrombosis / Q000188:drug therapy*
D011479:Protamines; D009270:Naloxone