A theoretical approach to chiral capillary electrophoresis with some practical implications.
A simple model has been proposed which explains enantiomeric resolution in capillary electrophoresis in terms of differential interactions with a chiral selector and differential migration of the two enantiomer-chiral selector complexes. The equations derived allow predictions to be made and there is good support for the model in literature data.
Wren
S A
SA
ZENECA Pharmaceuticals, Hurdsfield, Macclesfield, Cheshire.
Rowe
R C
RC
Payne
R S
RS
D003198:Computer Simulation; D004586:Electrophoresis / Q000379:methods*; D008956:Models, Chemical; D013237:Stereoisomerism