title: Parkinson's disease: a chronic, low-grade antioxidant deficiency?
abstract: The cause of Parkinson's disease (PD) is aggressively being pursued. Several hypotheses have been advanced, yet none of these completely explains the large body of evidence research has already uncovered. A new hypothesis, that PD is caused by a chronic antioxidant deficiency state, is outlined in this article. Oxidative stress, mitochondrial abnormalities, epidemiology, genetics, toxins, history of PD and diet are discussed.
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Denver.
authors.forename: C R
authors.initials: CR
authors.lastname: Burkhardt
authors.forename: H K
authors.initials: HK
authors.lastname: Weber
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D004032:Diet; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism
chemical_list: D000975:Antioxidants