title: Adult T-cell leukaemia with various abnormalities in endocrine and metabolic systems.
abstract: Adult T-cell leukaemia (ATL) is a unique type of T-cell malignancy closely associated with human T-cell leukaemia virus-1 (HTLV-1). Despite frequent descriptions of hypercalcaemia, cases accompanied by diabetes insipidus or syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) in ATL patients have rarely been reported. We present an unusual case of ATL with various abnormalities in his endocrine and metabolic systems involving anterior pituitary function, thyroid function, lipid metabolism and Ca metabolism. Some of these abnormalities were considered to arise from infiltration or leukaemic cells into systemic organs after elimination of the above symptoms. Clinical and haematological data showing improvement following chemotherapy are also presented.
authors.affiliation: Division of Haematology and Immunology, Shizuoka General Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Shiomura
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: N
authors.initials: N
authors.lastname: Kishimoto
authors.forename: K
authors.initials: K
authors.lastname: Iida
authors.forename: H
authors.initials: H
authors.lastname: Ikeno
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Sako
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002118:Calcium / Q000097:blood*; D006801:Humans; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000503:physiopathology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D013961:Thyroid Gland / Q000503:physiopathology*
chemical_list: D008055:Lipids; D002118:Calcium