title: Struvite diet in cats: effect of ammonium chloride and carbonates on acid base balance of cats.
abstract: Six healthy adult cats were fed a basal minced beef meat and rice diet (one meal per day) with varying amounts or combinations of acidifying and alkalizing additives (ammonium chloride, calcium and sodium carbonate). The base excess in the food (mmol/kg dry matter) was calculated (data on food compounds in g/kg dry matter) as follows: base excess = 49.9*Ca + 82.3*Mg + 43.5*Na + 25.6*K-64.6*P-13.4*met-16.6*cys-28.2*Cl. Base excess in the experimental diets amounted to between +305 and -1079 mmol/kg dry matter. After an adaptation period of 5 d, urine and blood pH as well as water and mineral balance were determined in the cats over a 10-15-d period. The daily mean urine pH ranged between 6.1 and 7.8. There was a highly significant correlation between the base excess in the food and the mean urine pH. The regression line was linear down to a base excess in the diet of approximately -400 to -500 mmol/kg dry matter and a pH in the urine of 6.2. The postprandial increase of urine pH was suppressed either by large amounts of ammonium chloride (> 780 mmol/kg dry matter) alone or in combination with calcium carbonate but not in combination with sodium carbonate. The relationship between the decrease of the blood pH and the amount of ammonium chloride added to the diet was more marked than the relationship between blood pH and base excess in the food.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Institute of Animal Nutrition, Tierärztliche Hochschule Hannover, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Kienzle
authors.forename: S
authors.initials: S
authors.lastname: Wilms-Eilers
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000643:Ammonium Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002254:Carbonates / Q000008:administration & dosage / Q000494:pharmacology*; D002371:Cat Diseases / Q000139:chemically induced / Q000178:diet therapy; D002415:Cats / Q000378:metabolism*; D004032:Diet; D004326:Drinking / Q000187:drug effects; D004435:Eating; D005243:Feces / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D010758:Phosphorus / Q000097:blood / Q000652:urine; D012044:Regression Analysis; D014545:Urinary Calculi / Q000178:diet therapy / Q000662:veterinary; D014556:Urine / Q000737:chemistry; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary
chemical_list: D002254:Carbonates; D000643:Ammonium Chloride; D010758:Phosphorus