Localization and morphology of antigen-presenting cells in the adenoid of children with otitis media with effusion.
This study describes the localization of antigen-presenting cells (APC) in the different compartments in adenoids of children with otitis media with effusion (OME) and "healthy" children and adults. It is shown that the adenoid of children with OME contains a relatively high number of OKT6 and RFD1 positive cells. Moreover, accumulations of these cells are present in the extrafollicular areas of these adenoids. Very occasionally dendritic cells in the epithelial microenvironment contain Birbeck granules, indicating characteristic Langerhans cells. These OKT6 positive cells are not seen in the adenoids of the control group. Our results clearly show a relation between the presence of dendritic cells and the occurrence of OME. No differences are seen in localization and morphology of the APC in the studied adenoids.
van Nieuwkerk
E B
EB
Department of Otorhinolaryngology, Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
van der Baan
S
S
Hoefsmit
E C
EC
Kamperdijk
E W
EW
D000135:Acid Phosphatase / Q000032:analysis; D000234:Adenoids / Q000276:immunology / Q000473:pathology*; D000911:Antibodies, Monoclonal; D000938:Antigen-Presenting Cells / Q000166:cytology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D010034:Otitis Media with Effusion / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000135:Acid Phosphatase