title: Hemolytic anemia with positive direct antiglobulin test secondary to spontaneous cytomegalovirus infection in healthy adults.
abstract: Hemolytic anemia with positive direct antiglobulin test in association with spontaneous cytomegalovirus (CMV) infection is a very rare event in healthy adults. We report here 2 patients who have recently suffered from this complication and review similar cases previously reported in the literature. Because CMV serology is not routinely obtained as a part of hemolysis work-up, the true incidence of this complication may be underestimated. We believe that CMV infection should be considered in the differential diagnosis of hemolytic anemia in adults.
authors.affiliation: Yale University School of Medicine, Yale Cancer Center, New Haven, Conn. 06520-8032.
authors.forename: E
authors.initials: E
authors.lastname: Salloum
authors.forename: W B
authors.initials: WB
authors.lastname: Lundberg
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis*; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D003176:Complement C3 / Q000032:analysis*; D003298:Coombs Test; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D000888:Antibodies, Anti-Idiotypic; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M