title: Idiopathic verapamil-responsive left ventricular tachycardia: clinical characteristics and long-term follow-up of 33 patients.
abstract: Long-term prognosis, pharmacological prophylaxis and transcatheter ablation in a large group of patients with idiopathic verapamil-responsive left ventricular tachycardia (IVRLVT) are reported in this study. Thirty-three patients with a mean age of 27 +/- 16 years at their first IVRLVT episode, were studied retrospectively. Ventricular tachycardia was of the right bundle branch block morphology in all cases, with left axis deviation in 29 and right axis deviation in five (one patient had the two morphologies). Mitral valve prolapse was present in four patients; no heart disease was found in the remaining 29. Ventricular tachycardia could be electrophysiologically induced in 90% of the patients; Holter monitoring showed only sporadic ventricular extrasystoles in 76%; late potentials were found in 33% of the cases. At the end of a follow-up of 5.7 +/- 4.7 years, no patient had died. Thirty-one patients (94%) received a mean of 2.5 +/- 1.2 drugs; beta-blockers were effective in 71% of the cases, verapamil in 25%, class 1 drugs in 22%, class 3 drugs in 18%. Two patients who never received prophylaxis and four in whom it was stopped, were controlled with verapamil in case of recurrence. Six patients underwent catheter ablation; two with DC shock in whom it was successful in one, and four with radiofrequency energy, with a total success rate. The good prognosis of IVRLVT has been confirmed in a long-term follow-up; a new finding is the high efficacy of beta-blockers for prophylaxis. Radiofrequency transcatheter ablation is an effective and safe therapy for patients with symptoms not controlled by drug treatment.
authors.affiliation: Cardiology Department of Ospedale Civile di Asti, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Gaita
authors.forename: C
authors.initials: C
authors.lastname: Giustetto
authors.forename: J F
authors.initials: JF
authors.lastname: Leclercq
authors.forename: M
authors.initials: M
authors.lastname: Haissaguerre
authors.forename: R
authors.initials: R
authors.lastname: Riccardi
authors.forename: L
authors.initials: L
authors.lastname: Libero
authors.forename: G
authors.initials: G
authors.lastname: Baralis
authors.forename: A
authors.initials: A
authors.lastname: Brusca
authors.forename: P
authors.initials: P
authors.lastname: Coumel
authors.forename: J F
authors.initials: JF
authors.lastname: Warin
mesh_terms: D000293:Adolescent; D000328:Adult; D017115:Catheter Ablation; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000150:complications; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular / Q000503:physiopathology* / Q000628:therapy; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D014700:Verapamil