title: Differential effects of lesions of the dorsomedial and dorsolateral caudate-putamen on reaction time performance in rats.
abstract: In order to investigate the role of the dorsomedial and dorsolateral caudate-putamen (CPu) in movement initiation of rats, we examined the effects of quinolinic acid lesions (30 nmol in 1 microliter) in these striatal subregions in a simple reaction time task. Results show that lesions of the dorsomedial, but not of the dorsolateral CPu increased reaction times. These findings provide further evidence for a functional heterogenity of the CPu and demonstrate an involvement of the dorsomedial CPu in processes related to rapid initiation of responses.
authors.affiliation: University of Tübingen, Department of Neuropharmacology, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hauber
authors.forename: W J
authors.initials: WJ
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D011699:Putamen / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology*