Effect of estrogenization in the first day of life on the reproductive system in male rats.
The aim of the present report was to investigate dynamics of morphological and functional changes in the reproductive system of male rats between 20th and 84th day of life, injected neonatally with a single dose of stilbestrol. Marked reduction in relative weights of testes and accessory sexual glands was demonstrated in various periods of life. This was associated with inhibition of spermatogenesis at the stage of primary spermatocytes and with morphological as well as functional alterations in epididymis, seminal vesicles and ventral prostate. In the serum, high levels of LH and lowered testosterone levels were demonstrated.
Limanowski
A
A
Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Miśkowiak
B
B
Otulakowski
B
B
D000818:Animals; D000831:Animals, Newborn; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D013739:Testosterone; D004054:Diethylstilbestrol; D007986:Luteinizing Hormone