Review of investigative diagnostic techniques for cutaneous lymphoma.
This article reviews the contribution of modern investigative techniques to the diagnosis of cutaneous lymphoproliferative diseases. Special attention is given to the significance of immunoglobulin and T-cell receptor rearrangements; as detected by Southern blotting and/or the polymerase chain reaction. Additional topics discussed include immunohistochemistry, cytogenetics, onco- and tumour suppressor genes and in-situ hybridization. It is recommended that the results of these techniques are interpreted in the form of a multifaceted diagnostic profile.
Slater
D N
DN
Department of Histopathology, Rotherham Hospital NHS Trust, United Kingdom.
D015139:Blotting, Southern; D015321:Gene Rearrangement / Q000276:immunology; D005819:Genetic Markers; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D005819:Genetic Markers