title: Gestagens in peripheral, uterine, ovarian and fetal blood in cows near term.
abstract: The aim of this study was to determine if bovine placenta is capable of producing the gestagen metabolites in vivo. The concentrations of 5 beta-pregnane-3 alpha-20 alpha-diol, 17 alpha,20 alpha-dihydroxyprogesterone and progesterone were measured by HPLC-RIA in samples obtained after surgical preparation from peripheral, uterine, fetal and ovarian blood of seven cows near term. Measurement of arterio-venous differences in maternal uterine and umbilical circulation confirmed the placental origin of 5 beta-pregnance-3 alpha,20 alpha-diol and 17 alpha,20 alpha-dihydroxyprogesterone, but not progesterone itself. 5 beta-pregnane-3 alpha,20 alpha-diol was preferentially secreted into the fetal compartment. The present experiment, according to earlier in-vitro studies, confirms that the preterm bovine placenta is qualified for in-vivo utilization and secretion of gestagen metabolites.
authors.affiliation: Department of Obstetrics, Faculty of Veterinary Medicine, Academy of Agriculture and Technology, Olsztyn, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Janowski
mesh_terms: D000818:Animals; D002417:Cattle / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D010053:Ovary / Q000098:blood supply*; D011247:Pregnancy; D011372:Progestins / Q000097:blood*; D014599:Uterus / Q000098:blood supply*
chemical_list: D011372:Progestins