title: Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.
abstract: Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.
authors.affiliation: Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.
authors.forename: W
authors.initials: W
authors.lastname: Ding
authors.forename: D R
authors.initials: DR
authors.lastname: Williams
authors.forename: P
authors.initials: P
authors.lastname: Northcote
authors.forename: M M
authors.initials: MM
authors.lastname: Siegel
authors.forename: R
authors.initials: R
authors.lastname: Tsao
authors.forename: J
authors.initials: J
authors.lastname: Ashcroft
authors.forename: G O
authors.initials: GO
authors.lastname: Morton
authors.forename: M
authors.initials: M
authors.lastname: Alluri
authors.forename: D
authors.initials: D
authors.lastname: Abbanat
authors.forename: W M
authors.initials: WM
authors.lastname: Maiese
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C091121:pyrroindomycin A; C091122:pyrroindomycin B