Effect of metallothionein I on mitochondrial oxygen consumption.
The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied. Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT. The MT effect was concentration dependent. No evidence was found for the provision by MT of an alternate pathway to oxygen.
Simpkins
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University of Maryland School of Medicine, Department of Surgery, Baltimore.
Zhao
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Torrence
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D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004579:Electron Transport / Q000187:drug effects; D008297:Male; D008668:Metallothionein / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D017967:Zinc Compounds / Q000494:pharmacology
D002712:Chlorides; D013386:Succinates; D017967:Zinc Compounds; D002104:Cadmium; D000244:Adenosine Diphosphate; C016837:zinc chloride; D008668:Metallothionein; D019802:Succinic Acid; D019256:Cadmium Chloride