title: [Blood gastrin changes in the late postoperative period after proximal gastric vagotomy].
abstract: Changes in serum gastrin levels in the late postoperative period have been studied in 24 patients with non-stenotic duodenal ulcer who underwent proximal gastric vagotomy. Twenty healthy volunteers were used as a control group. Serum gastrin levels were determined under basal conditions and after a high protein meal stimulation. Both measurements were done in the preoperative, early postoperative (12th day) and late postoperative periods (X = 5.5 yrs.). Regarding basal serum gastrin levels, the results show mean values of 46.2 pg/ml in the preoperative, 61.6 pg/ml in the early postoperative, 73.9 pg/ml in the late postoperative and 51 pg/ml in the control group. Early and late postoperative period values show statistical significant differences when compared with preoperative values (p < 0.05), but not with the control group ones. Stimulated gastrin levels show mean values of 75.7 pg/ml in the preoperative, 99.1 pg/ml in the early postoperative, 134.1 pg/ml in the late postoperative and 73.4 pg/ml in the control group. Late postoperative values show statistical significant differences when compared with preoperative and early postoperative values (p < 0.05), and also when compared with the control group (p < 0.05). Possible causes and the physiopathological effects of these variations are discussed.
authors.affiliation: Facultad de Medicina, III Cátedra de Cirugía, Hospital Universitario San Carlos, Universidad Complutense, Madrid.
authors.forename: J R
authors.initials: JR
authors.lastname: Núñez Peña
authors.forename: C
authors.initials: C
authors.lastname: Martínez Ramos
authors.forename: R
authors.initials: R
authors.lastname: Sanz López
authors.forename: M
authors.initials: M
authors.lastname: Ruiz de Gopequi
authors.forename: T W
authors.initials: TW
authors.lastname: Jorgensen
authors.forename: E S
authors.initials: ES
authors.lastname: Tamames
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004044:Dietary Proteins; D004381:Duodenal Ulcer / Q000097:blood / Q000601:surgery; D017558:Elective Surgical Procedures; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013997:Time Factors; D014629:Vagotomy, Proximal Gastric
chemical_list: D004044:Dietary Proteins; D005755:Gastrins
vernacular_title: Alteraciones de la gastrinemia en el postoperatorio tardío tras vagotomía gástrica proximal.