The effect of amino acids and amino acid derivatives on cell proliferation.
The effect of certain amino acids and amino acid derivatives on cell proliferation have been studied in the author's Institute for more than 25 years. The optically active forms of arginine, lysine, aspartic acid and glutamic acid influence the growth of transplantable rat tumors. L-arginine, D-lysine, L-aspartic acid and D-glutamic acid promoted; D-aspartic acid, L-glutamic acid, D-arginine and L-lysine inhibited tumour growth. E-amino trimethyl-lysine (TML) stimulated cell proliferation in various cell systems (bone marrow, small intestine, cultured lymphocytes). When administered simultaneously with high doses of Cyclophosphamide, Vincristin or Doxorubicin to tumour-bearing mice, TML decreased the toxicity of the antitumour drugs, resulting in a higher rate of survivors. L-leucine methyl ester caused cell death of mouse peritoneal macrophages by inducing disruption of macrophages.
Szende
B
B
1st Institute of Pathology and Experimental Cancer Research, Semmelweis University Medical School, Budapest, Hungary.
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D016923:Cell Death; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology; D012517:Sarcoma, Yoshida / Q000188:drug therapy / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects
D000596:Amino Acids; D000970:Antineoplastic Agents; C030365:leucine methyl ester; C003712:trimethyllysine; D004317:Doxorubicin; D007930:Leucine; D008239:Lysine