Decreased cyclosporin A absorption after treatment with GoLytely lavage solution in rats.
Recently we observed a case in which the cyclosporin A absorption decreased after treatment with GoLytely lavage solution in a kidney transplant patient. In this study, we confirmed the decrease of the blood concentration of cyclosporin A after oral administration by GoLytely (Macrogol 3350) based on experiments with rats. The peak blood cyclosporin A concentration, and the area under the blood drug concentration-time curve from 0 to 24 h in the GoLytely-administered group were significantly lower than the control group. In the case of gastrointestinal dysfunction such as diarrhoea, or in treatment with laxatives such as GoLytely lavage solution, whole blood cyclosporin levels must be carefully monitored, and intravenous cyclosporin A may be more suitable for providing adequate immunosuppression.
Santa
T
T
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Japan.
Nishihara
K
K
Horie
S
S
Kotaki
H
H
Sawada
Y
Y
Kawabe
K
K
Iga
T
T
D000704:Analysis of Variance; D000818:Animals; D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004573:Electrolytes / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007165:Immunosuppression Therapy; D007408:Intestinal Absorption / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D008954:Models, Biological; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions
D004573:Electrolytes; C033608:Golytely; D012996:Solutions; D011092:Polyethylene Glycols; D016572:Cyclosporine