title: Antioxidant and radical scavenging effects of aged garlic extract and its constituents.
abstract: The antioxidant properties of three garlic preparations and organosulfur compounds in garlic have been determined. Aged garlic extract inhibited the emission of low level chemiluminescence and the early formation of thiobarbituric acid-reactive substances (TBA-RS) in liver microsomal fraction initiated by t-butyl hydroperoxide. However, the water extracts of raw and heat-treated garlic enhanced the emission of low level chemiluminescence. Among the variety of organosulfur compounds, S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), the major organosulfur compounds found in aged garlic extract, showed radical scavenging activity in both chemiluminescence and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays, indicating that these compounds may play an important role in the antioxidative activity of aged garlic extract.
authors.affiliation: Institute for OTC Research, Wakunaga Pharmaceutical Co. Ltd., Hiroshima, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Imai
authors.forename: N
authors.initials: N
authors.lastname: Ide
authors.forename: S
authors.initials: S
authors.lastname: Nagae
authors.forename: T
authors.initials: T
authors.lastname: Moriguchi
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: Y
authors.initials: Y
authors.lastname: Itakura
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005737:Garlic; D008163:Luminescent Measurements; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010545:Peroxides / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D020122:tert-Butylhydroperoxide
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D010545:Peroxides; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D020122:tert-Butylhydroperoxide; D003545:Cysteine