title: HLA non-identical T-cell-depleted bone marrow transplantation for primary immunodeficiency diseases.
abstract: BACKGROUND
  Bone marrow transplantation (BMT) is usually the only procedure offering cure for children with life-threatening immune deficiency disorders, but compatible sibling donors are frequently unavailable.
  
  
  OBJECTIVE
  To examine the outcome of HLA non-identical T-cell-depleted BMT carried out between April 1985 and May 1992 in 11 patients with primary immunodeficiency diseases and to seek prognostic factors.
  
  
  RESULTS
  Eight patients achieved sustained engraftment, one after a second BMT. One further patient engrafted transiently, but rejected the graft five months later. Acute graft-versus-host disease (GVHD) grade II was seen in one and chronic GVHD was seen in three children. Seven patients survived beyond six months, six with donor T cell and five with donor B cell engraftment. At present, five patients (46%) are alive with immune reconstitution at a median follow-up of 14 months (range 6 to 78 months). The major factor associated with outcome was the presence of any infection within one week of BMT (p = 0.01). The presence of lung infection also tended to be a poor prognostic factor (p = 0.06) but did not reach significance, presumably because of the small sample size. HLA non-identical (parental) T-cell depleted BMT plays an important role in the cure of children with immunodeficiencies who do not have an identical sibling donor. Survival can be further improved if the diagnosis of immunodeficiency disease is made early and BMT undertaken before significant infections occur.
  
  
  CONCLUSIONS
  The availability of T-cell depleted haploidentical parental bone marrow transplant can be anticipated to improve outcome significantly for children with severe immunodeficiency, especially when diagnosed early.
authors.affiliation: Paediatric Haematology/Oncology Prince of Wales Children's Hospital, Sydney, NSW.
authors.forename: N
authors.initials: N
authors.lastname: Giri
authors.forename: M
authors.initials: M
authors.lastname: Vowels
authors.forename: J B
authors.initials: JB
authors.lastname: Ziegler
authors.forename: D
authors.initials: D
authors.lastname: Ford
authors.forename: R
authors.initials: R
authors.lastname: Lam-Po-Tang
mesh_terms: D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000453:epidemiology; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007223:Infant; D008212:Lymphocyte Depletion; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016511:Severe Combined Immunodeficiency / Q000401:mortality / Q000628:therapy*; D013601:T-Lymphocytes; D013997:Time Factors; D018183:Transplantation Chimera
chemical_list: D006680:HLA Antigens