Quantal properties of H-type glutamatergic synaptic input to the striatal medium spiny neurons.
The striatal medium spiny neuron receives two distinct glutamatergic synaptic inputs, S-type and H-type inputs, which have very different amplitudes. We report here that peak amplitudes of unitary H-type excitatory postsynaptic currents (EPSCs) could be reduced by decreasing external Ca2+, unlike S-type EPSCs. This suggests that H-type EPSCs are multiquantal, and supports the idea that the cellular origin of H-type EPSCs is distinct from that of the S-type EPSCs.
Mori
A
A
Department of Physiology, Faculty of Medicine, University of Tokyo, Japan.
Takahashi
T
T
Miyashita
Y
Y
Kasai
H
H
D000818:Animals; D002118:Calcium / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000502:physiology*; D066298:In Vitro Techniques; D017072:Neostriatum / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*
D005971:Glutamates; D002118:Calcium