[Therapeutic efficacy of lanoconazole ointment in guinea pig model of tinea pedis, in comparison with that of cream preparations].
The therapeutic efficacy of ointment and cream preparations of lanoconazole in a guinea pig model of tinea pedis was compared. When infected animals were treated once daily with 0.25% and 0.5% lanoconazole ointments, 7 of 10 and 8 of 10 infected feet became culture-negative, respectively. In animals treated with 1% lanoconazole ointment, fungus was not recovered from any infected foot. Comparing these results with those of culture study in animals which were treated with comparable concentrations of lanoconazole cream, no significant differences were found. These studies, therefore, suggested that ointment and cream preparations of lanoconazole on topical application in the tinea pedis model would show basically equivalent therapeutic efficacy.
Niwano
Y
Y
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd.
Tabuchi
T
T
Kanai
K
K
Hamaguchi
H
H
Uchida
K
K
Yamaguchi
H
H
D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D009824:Ointments; D014008:Tinea Pedis / Q000188:drug therapy*
D006571:Heterocyclic Compounds; D007093:Imidazoles; D009824:Ointments; C072774:latoconazole