title: Effects of ritanserin, a novel serotonin-S2 receptor antagonist, on the secretion of pituitary hormones in normal humans.
abstract: The availability of a new potent and selective serotonin-S2 antagonist, ritanserin (RIT), encouraged us to further investigate the effect of serotonin on the basal secretion of anterior pituitary hormones in normal humans. Administered in a single 30-mg dose to group 1 consisting of 10 normal women, RIT failed to affect the baseline LH, FSH, GH or TSH levels. In group 2 consisting of 20 normal subjects (ten males and ten females), the same dose of RIT decreased in parallel both ACTH and cortisol levels but only at 180 min. Group 3 consisting of 8 normal men was studied on three separate occasions seven days apart: each subject received graded doses of 10 mg, 20 mg and 30 mg RIT. The mean baseline PRL concentration at 180 min as well as the net integrated area under the hormone curve (nAUC) decreased only after the highest dose, while the baseline cortisol concentrations at 180 min as well as the corresponding nAUC values displayed a clear dose-dependent response. The findings indicated the serotonin-S2 receptors to be only partially involved in the basal secretion of ACTH in normal humans.
authors.affiliation: Department of Internal Medicine, Zagreb University School of Medicine, Zagreb Clinical Center, Croatia.
authors.forename: D
authors.initials: D
authors.lastname: Tepavcević
authors.forename: Z
authors.initials: Z
authors.lastname: Giljević
authors.forename: M
authors.initials: M
authors.lastname: Korsić
authors.forename: S
authors.initials: S
authors.lastname: Halimi
authors.forename: E
authors.initials: E
authors.lastname: Suchanek
authors.forename: T
authors.initials: T
authors.lastname: Jelić
authors.forename: I
authors.initials: I
authors.lastname: Aganović
authors.forename: B
authors.initials: B
authors.lastname: Kozić
authors.forename: V
authors.initials: V
authors.lastname: Plavsić
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism; D016713:Ritanserin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism
chemical_list: D012702:Serotonin Antagonists; D016713:Ritanserin; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone