title: Structure-activity relationships for relaxation of smooth muscle by VIP.
abstract: Utilizing VIP and five VIP analogues, concentration-response curves for relaxation of rat mesenteric artery and rat gastric longitudinal muscle were determined for comparison with our previously published radioligand binding data on rat smooth muscle and other tissues. The biological potency of the VIP analogues in the present study compared more closely with their potency for VIP receptor binding in smooth muscle tissue (arteries) vs. other tissues (pituitary, brain, liver).
authors.affiliation: Department of Medicine, University of Calgary, Calgary General Hospital, Alberta, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Shirahase
authors.forename: D H
authors.initials: DH
authors.lastname: Coy
authors.forename: O P
authors.initials: OP
authors.lastname: Rorstad
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005748:Gastric Fundus / Q000166:cytology; D008297:Male; D017538:Mesenteric Artery, Superior / Q000166:cytology; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D018005:Receptors, Vasoactive Intestinal Peptide / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014660:Vasoactive Intestinal Peptide / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide