15-Deoxyspergualin controls cyclosporin- and steroid-resistant intestinal acute graft-versus-host disease after allogeneic bone marrow transplantation.
We report a case of cyclosporin- and methylprednisolone-resistant intestinal acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation which responded to a new immunosuppressant, 15-deoxyspergualin (DSG). Endoscopy showed lymphoid hyperplasia with CD3+, CD4+, CD8- lymphocyte infiltration into the submucosa of the jejunum and colon. DSG effectively suppressed this intestinal acute GVHD.
Kasai
M
M
Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital, Japan.
Higa
T
T
Naohara
T
T
Masauzi
N
N
Watanabe
M
M
Matsuura
A
A
Ohizumi
H
H
Tanaka
J
J
Morii
K
K
Kiyama
Y
Y
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016572:Cyclosporine / Q000627:therapeutic use; D004351:Drug Resistance; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007410:Intestinal Diseases / Q000188:drug therapy*; D008297:Male; D014184:Transplantation, Homologous
D000305:Adrenal Cortex Hormones; D006146:Guanidines; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C037258:gusperimus