title: Experimental idiopathic dilated cardiomyopathy under low-calcium condition.
abstract: Administration of long-term, low-dose Na2EDTA leads to moderate or severe thinning of the right ventricular wall with or without rupture. These morphological manifestations are known to be site-dependent on the constriction of pulmonary arteries (Yamaguchi et al. 1993a). They sometimes ensue from aneurysmal dilatation and/or plexiform-like-lesion in a pulmonary artery (Yamaguchi et al. 1993b). The present contribution reports that experimental animals who survived for a longer period, maximum for 6 months, showed dilatation of the left ventricle with a mode-rately thin ventricular wall as well as right ventricular changes, which are similar to the morphological manifestations in idiopathic dilated cardiomyopathy.
authors.affiliation: Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Kaku
authors.forename: T
authors.initials: T
authors.lastname: Onodera
authors.forename: R
authors.initials: R
authors.lastname: Kurokawa
authors.forename: M
authors.initials: M
authors.lastname: Morisada
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced / Q000473:pathology*; D004492:Edetic Acid; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology*; D008297:Male; D009206:Myocardium / Q000473:pathology*
chemical_list: D004492:Edetic Acid