title: [Early or late orchidopexy? An evaluation of germ cell proliferation by PCNA immune expression].
abstract: A immunocytochemical study for detection of proliferating cell nuclear antigen (PCNA) in order to quantify the number of PCNA-positive spermatogonia, and cytophotometric determination of spermatogonial DNA were performed in cryptorchid and control testes. The number of PCNA-positive spermatogonia, and the average DNA content of spermatogonia in the cryptorchid testes were altered from first years of age. These precocious spermatogonial alterations suggest that the early surgical testicular descent doesn't prevent lesions of germ cells.
authors.affiliation: Departamento de Cirugía Pediátrica, Hospital Infantil La Paz, Madrid.
authors.forename: A
authors.initials: A
authors.lastname: Queizán
authors.forename: M C
authors.initials: MC
authors.lastname: Carrero
authors.forename: M M
authors.initials: MM
authors.lastname: Perdiguero
authors.forename: L
authors.initials: L
authors.lastname: Santamaría
authors.forename: S
authors.initials: S
authors.lastname: Candelas
authors.forename: M
authors.initials: M
authors.lastname: Nistral
authors.forename: J
authors.initials: J
authors.lastname: Codesal
mesh_terms: D000375:Aging / Q000276:immunology*; D001706:Biopsy; D002455:Cell Division / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000276:immunology / Q000473:pathology / Q000601:surgery; D004247:DNA / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D013093:Spermatogonia / Q000166:cytology / Q000276:immunology*; D013737:Testis / Q000276:immunology* / Q000473:pathology / Q000601:surgery*
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D004247:DNA
vernacular_title: Orquidopexia precoz o tardía? Valoración de la proliferación de las células germinales mediante inmunoexpresión de PCNA.