Synthesis and anticonvulsant activity of new 4- thiazolidone and 4-thiazoline derivatives.
A number of 2-(2-furoylhydrazono)-3-substituted 4-thiazolidone and 2-(2-furoylhydrazono)-3,4-disubstituted 4-thiazoline derivatives were synthesized and evaluated for anticonvulsant activity. Most of the tested compounds showed significant activity against MES induced seizures.
Ergenç
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Capan
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G
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D004597:Electroshock; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D013844:Thiazoles