title: Predictors of (non-) response in depressed outpatients treated with a three-phase sequential medication strategy.
abstract: The predictive value of eight domains or sets of variables including sociodemographic aspects, premorbid history, symptomatology, personality, social and diagnostic data are evaluated in depressed outpatients with a Hamilton Rating Scale for Depression (HRSD) score of at least 14. Patients were treated using a three-phase sequential treatment strategy. Of the 119 patients, 88 completed the trial. The HRSD-score at the end of phases I, II or III was used as an outcome measure. Patients with an initially high HRSD-score and an obsessive-compulsive personality had a greater chance of recovery, while patients with somatization and a passive-aggressive personality had less of a chance of recovery. Variables involving psychiatric history, premorbid history or symptomatology of the depression, were not significantly related to outcome. The endogenous/non-endogenous distinction was not a predictor of response.
authors.affiliation: Out-patient Department, Psychiatric Centre Bloemendaal, The Hague, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Hoencamp
authors.forename: P M
authors.initials: PM
authors.lastname: Haffmans
authors.forename: H
authors.initials: H
authors.lastname: Duivenvoorden
authors.forename: H
authors.initials: H
authors.lastname: Knegtering
authors.forename: W A
authors.initials: WA
authors.lastname: Dijken
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008376:Maprotiline / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D010552:Personality Assessment; D010555:Personality Inventory; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; D008376:Maprotiline; C038213:brofaromine; D008094:Lithium