[Mechanisms of cardiac involvement in systemic scleroderma, apropos of 3 cases].
We studied myocardial manifestations of systemic sclerosis in three patients. Two patients were symptomatic. A transthoracic echocardiography, a coronary angiography, a cardiac catheterization, thallium scans with dipyridamol completed by thoracic cold exposure and endomyocardial biopsy with immunohistological study were performed. None of them have coronary stenosis. In the three cases abnormalities of myocardial perfusion were detected, two of them have fibrosis. The immunohistological study always showed an anusual expression of HLA DR on cardiac fibroblasts.
Milesi-Lecat
A M
AM
Service de médecine interne, CHRU Nord, Clermont-Ferrand.
Cauhape
P
P
Schmidt
J
J
Marcaggi
X
X
Peycelon
P
P
Kemeny
J L
JL
Lusson
J R
JR
Frances
C
C
Marcheix
J C
JC
Aumaitre
O
O
D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications*
Mécanismes de l'atteinte cardiaque dans la sclérodermie systémique (à propos de trois observations).