Effect of 8-hydroxy-, 8-mercapto- and 5-chloro-7-iodo-8-hydroxy-quinoline on the uptake and distribution of nickel in mice.
Oral administration of Ni2+ together with 8-hydroxyquinoline (8-OH-quinoline), 8-mercaptoquinoline (8-SH-quinoline) or 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol) resulted in increased tissue levels of the metal in several tissues of mice in comparison with animals given the Ni2+ alone. Ni2+ forms lipophilic complexes with these compounds and it can be assumed that this will facilitate the uptake of the Ni2+ over the walls of the gastrointestinal tract. Our results showed that 8-SH-quinoline, in contrast to 8-OH-quinoline and and clioquinol, induces a markedly changed distribution pattern of the Ni2+ in the body, with uptake of the metal in tissues such as the central nervous system, pigmented tissues, the pancreatic islets and the thyroid. It is probable that the Ni(2+)-complex with 8-SH-quinoline is stable enough to persist for a time period in the tissues and that the obtained pattern partly reflects the distribution of the complexed metal. In contrast, following the absorption from the gastrointestinal tract there may be a dissociation of the complexes between Ni2+ and 8-OH-quinoline or clioquinol, resulting in increased metal levels in various tissues, but with similar distribution as when the Ni2+ is given alone.
Borg-Neczak
K
K
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala Biomedical Centre.
Tjälve
H
H
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D007464:Clioquinol / Q000494:pharmacology*; D005123:Eye / Q000378:metabolism; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009532:Nickel / Q000493:pharmacokinetics*; D015125:Oxyquinoline / Q000494:pharmacology*; D010179:Pancreas / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*; D011868:Radioisotopes; D013961:Thyroid Gland / Q000378:metabolism; D014018:Tissue Distribution
D011804:Quinolines; D011868:Radioisotopes; C087618:8-mercaptoquinoline; D015125:Oxyquinoline; C022838:nickel chloride; D007464:Clioquinol; D009532:Nickel