title: Relationship between epidermal growth factor receptor and other prognostic factors in gynecological cancers.
abstract: In 62 cases of gynecological malignancies, 16 of the ovarian, 31 of the endometrium and 15 of the cervix, the EGF-R status was evaluated in order to establish its prognostic value and its correlation with other classical prognostic factors. We have failed to demonstrate any correlation between EGF-R status and stage, grade and hormonal receptors, ER/PgR, in ovarian and cervical cancer. In contrast, in endometrial cancer, we observed significantly lower levels of EGF-R in poorly differentiated tumors. Moreover, a weak negative relationship between EGF-R and PgR status was found. Regarding survival, we noticed a better prognosis in patients with ovarian cancer EGF-R positive, but without statistical significance.
authors.affiliation: Department of Obstetrics and Gynecology, University of Parma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Melpignano
authors.forename: E
authors.initials: E
authors.lastname: Vadora
authors.forename: D
authors.initials: D
authors.lastname: Debiasi
authors.forename: C
authors.initials: C
authors.lastname: Merisio
authors.forename: S
authors.initials: S
authors.lastname: Piombo
authors.forename: M
authors.initials: M
authors.lastname: Brusati
authors.forename: L
authors.initials: L
authors.lastname: Catozzi
authors.forename: G
authors.initials: G
authors.lastname: Giovannini
authors.forename: A
authors.initials: A
authors.lastname: Piffanelli
authors.forename: A
authors.initials: A
authors.lastname: Merialdi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology
chemical_list: D066246:ErbB Receptors