Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial.
In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.
Koman
L A
LA
Department of Orthopaedics, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1070.
Mooney
J F
JF
Smith
B P
BP
Goodman
A
A
Mulvaney
T
T
D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005531:Foot Deformities, Acquired / Q000188:drug therapy* / Q000209:etiology; D005684:Gait; D006801:Humans; D007273:Injections, Intramuscular; D009128:Muscle Spasticity / Q000188:drug therapy; D016059:Range of Motion, Articular
D001905:Botulinum Toxins