[Progress in knowledge about fibrinolysis regulation].
Plasminogen activator inhibitor-1 (PAI-1) plays particularly important role in regulation of homeostasis of fibrinolytic system. It neutralizes active molecules of tissue-type and urokinase-type plasminogen activators. PAI-1 is synthesized mainly in endothelial cells but it is present also in other cells. It was found in vitro that elevated expression of PAI-1 gene and increase in PAI-1 concentration released from endothelium is caused by many different biologically active substances. Among them there are thrombin, lipopolysaccharides, cell growth factors, cytokines and also glucocorticoids and phorbol esters. In this work mechanisms of regulation of PAI-1 synthesis and role of this protein in homeostasis of fibrinolytic system are described.
Cierniewski
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CS
Zakładu Biofizyki Akademii Medycznej, Lodzi.
D000818:Animals; D018076:DNA, Complementary / Q000032:analysis; D005342:Fibrinolysis / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*
D018076:DNA, Complementary; D017395:Plasminogen Activator Inhibitor 1
Postepy wiedzy o regulacji fibrynolizy.