[Characteristics of CDDP-PLA microspheres in vitro and in vivo].
Studies on the drug release in vitro and hepatic arterial chemoembolization in vivo were carried out with the newly developed CDDP-PLA microspheres. The mechanism of the in vitro release was shown to conform to Higuchi equation. After chemoembolization the CDDP-PLA microspheres showed remarkably lower CDDP concentrations in the general circulation and much higher concentrations in the hepatic tissue e. g. up to 21.55 +/- 12.18 micrograms/g at 8 h, which is much higher than that (3.16 +/- 0.09 micrograms/g) of the CDDP in hepatic arterial infusions. Thus, the CDDP-PLA microspheres may improve the curative effects and lower the side effects, especially the kidney toxicity, of the anticancer drug cisplatin.
Liu
Z K
ZK
514 Hospital, Beijing.
Wei
S L
SL
Lan
C Q
CQ
Su
D Y
DY
D000818:Animals; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004285:Dogs; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D008863:Microspheres; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D002945:Cisplatin