Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.
Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.
Ding
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Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.
Williams
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DR
Northcote
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P
Siegel
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MM
Tsao
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R
Ashcroft
J
J
Morton
G O
GO
Alluri
M
M
Abbanat
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D
Maiese
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WM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides; C091121:pyrroindomycin A; C091122:pyrroindomycin B