[The structural-functional properties of the erythrocyte membranes in patients with ischemic stroke and circulatory encephalopathy].
68 patients with cerebrovascular disorders (37 cases of ischemic stroke and 31 cases of dyscirculatory encephalopathy) were examined for microhemorheology (erythrocytic form and deformability); fractional composition of neutral lipids; blood phospholipids; those in red cells and their membrane environment (ME); erythrocytic sorption capacity in plasma and ME by fibrinogen. Neutral lipids were found to undergo metabolic disorders manifested as lowered amount of phospholipids, elevated levels of free fatty acids, triglycerides and cholesterol ethers. The fractional composition shifted to a growing toxic fraction of lysophosphatides and reducing fraction of phosphatydilcholine. The changes were of the same type in all the tested media and seemed interrelated. Along with alterations in the membrane lipid composition there appeared functional changes in erythrocytes: deformability decreased, echinocytes emerged, membrane sorption capacity enhanced, ME fibrinogen rose.
Ageeva
T S
TS
Zakharova
N B
NB
Rassomakhin
A A
AA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood / Q000503:physiopathology*; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000502:physiology / Q000648:ultrastructure*; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged
D008055:Lipids; D008563:Membrane Lipids; D005340:Fibrinogen
Strukturno-funktsional'nye svoĭstva éritrotsitarnykh membran u bol'nykh s ishemicheskim insul'tom i distsirkuliatornoĭ éntsefalopatieĭ.