Effect of vinconate on long-term potentiation in a mossy fiber-CA3 system of guinea pig hippocampal slices.
We investigated the effect of vinconate on the long-term potentiation of population spikes following the stimulation of mossy fibers in the CA3 pyramidal layer of hippocampal slices from guinea pig brain. Vinconate (10(-7) and 10(-6) M) dose-dependently augmented the long-term potentiation in the mossy fiber-CA3 system. This effect was reduced by treatment with scopolamine at a concentration of 10(-6) M, which showed no significant change in the long-term potentiation in a mossy fiber-CA3 system. These results suggest that vinconate may augment long-term potentiation in the mossy fiber-CA3 system partly via activation of the cholinergic system.
Arita
K
K
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Araki
T
T
Shuto
K
K
Satoh
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D012601:Scopolamine / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology*
D014748:Vinca Alkaloids; C038627:vinconate; D012601:Scopolamine