[Amplification of C-erB2 gene in ovarian cancer].
In the present report, amplification of C-erbB2 proto-oncogene in ovarian cancer was studied with Southern Blot technique. There were 14 cases to occur amplification of C-erbB2 oncogene in 50 cases with ovarian cancer. Among 14 ovarian cancer cases with amplification of C-erbB2, 2 of 20 cases were detected in stage I and II respectively, while 12 of 30 cases were from stage III/IV (P < 0.05). These results showed that amplification of C-erbB2 proto-oncogene is associated with advanced ovarian cancer. Therefore, it is suggested that C-erbB2 gene amplification may deserve further evaluation as a prognostic marker in ovarian cancer.
Zhang
G L
GL
Cancer Hospital, Shanghai Medical University.
Zu
K L
KL
Yu
S Y
SY
D014408:Biomarkers, Tumor / Q000235:genetics*; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D018734:Genes, erbB-2; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D000090063:Proto-Oncogene Mas; D018719:Erb-b2 Receptor Tyrosine Kinases; C000715470:MAS1 protein, human