title: Effect of ventilation on first-pass pulmonary retention of alfentanil and sufentanil in patients undergoing coronary artery surgery.
abstract: We have studied, in 14 patients undergoing elective aorto-coronary bypass surgery, the effect of the type of ventilation on pulmonary retention of alfentanil and sufentanil using a double indicator technique. Patients were allocated to one of two groups to receive either bolus doses of sufentanil 33.2 micrograms (n = 6) or alfentanil 654 micrograms (n = 8), mixed with indocyanine green. In each patient, pulmonary first-pass retention was studied during apnoea (during the 1-min study period), normoventilation and positive end-expiratory pressure (10 mm Hg) ventilation, the order of which was randomized. After sufentanil, mean (95% confidence interval) first-pass pulmonary retention was 50.9 (41.7-60.1)% during apnoea, 50.8 (42.9-58.8)% during normoventilation and 54.4 (43.7-65.0)% during positive end-expiratory pressure ventilation. After alfentanil, first-pass pulmonary retention was 18.7 (5.4-32.0)% during apnoea, 19.9 (8.3-31.5)% during normoventilation and 16.6 (5.6-27.6)% during positive end-expiratory pressure ventilation. First-pass pulmonary retention of alfentanil and sufentanil was not significantly affected by the type of ventilation.
authors.affiliation: Department of Anaesthesiology, University Hospital Leiden, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Boer
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
authors.forename: A G
authors.initials: AG
authors.lastname: Burm
authors.forename: A
authors.initials: A
authors.lastname: Hak
mesh_terms: D015760:Alfentanil / Q000493:pharmacokinetics* / Q000494:pharmacology; D000768:Anesthesia, General; D001049:Apnea / Q000378:metabolism; D001026:Coronary Artery Bypass; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007208:Indocyanine Green; D007385:Intermittent Positive-Pressure Ventilation; D008168:Lung / Q000378:metabolism*; D011175:Positive-Pressure Respiration; D017409:Sufentanil / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D015760:Alfentanil; D017409:Sufentanil; D007208:Indocyanine Green