title: Treatment of stiff-man syndrome with intravenous immune globulin.
abstract: OBJECTIVE
  To evaluate the efficacy of intravenous immune globulin (IVIG) in the treatment of stiff-man syndrome (SMS).
  
  
  METHODS
  An open, unblinded study of 3 patients with active disease and/or disease refractory to treatment with diazepam and/or corticosteroids.
  
  
  RESULTS
  All 3 bedridden patients improved substantially shortly after infusion with IVIG and regained function.
  
  
  CONCLUSIONS
  IVIG may be useful for the treatment of SMS.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: E W
authors.initials: EW
authors.lastname: Karlson
authors.forename: L
authors.initials: L
authors.lastname: Sudarsky
authors.forename: E
authors.initials: E
authors.lastname: Ruderman
authors.forename: S
authors.initials: S
authors.lastname: Pierson
authors.forename: M
authors.initials: M
authors.lastname: Scott
authors.forename: S M
authors.initials: SM
authors.lastname: Helfgott
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008875:Middle Aged; D016750:Stiff-Person Syndrome / Q000150:complications / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous