Interleukin-10 and pentoxifylline inhibit C-reactive protein-induced tissue factor gene expression in peripheral human blood monocytes.
Fibrin deposition is an integral feature of the inflammatory response. In response to C-reactive protein (CRP), an acute-phase reactant, blood monocytes synthesize and express tissue factor (TF), the main initiator of blood coagulation. We report the inhibitory effect of interleukin 10 (IL-10) and that of pentoxifylline, a methyl xanthine derivative, on monocyte expression of TF activity, TF protein and TF mRNA in response to CRP. These agents may be of use in diseases where a TF-induced prothrombotic state is detrimental.
Ramani
M
M
INSERM U294, CHU Xavier Bichat, Paris, France.
Khechai
F
F
Ollivier
V
V
Ternisien
C
C
Bridey
F
F
Hakim
J
J
de Prost
D
D
D002097:C-Reactive Protein / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D010431:Pentoxifylline / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D013925:Thromboplastin / Q000096:biosynthesis / Q000235:genetics*
D012333:RNA, Messenger; D016753:Interleukin-10; D002097:C-Reactive Protein; D013925:Thromboplastin; D010431:Pentoxifylline