A multi-center analysis of the use of enalapril and lisinopril in elderly hypertensive patients.
OBJECTIVE
To evaluate the clinical use and adverse effects of enalapril and lisinopril in elderly hypertensive subjects.


METHODS
A multi-center, retrospective, drug use evaluation survey.


METHODS
Ambulatory care clinics at 14 VA and 14 academic medical centers.


METHODS
422 elderly (> 60 years of age) patients with hypertension and no clinical evidence of congestive heart failure.


METHODS
At least 3 consecutive months of anti-hypertensive therapy with either enalapril or lisinopril.


METHODS
Blood pressure, serum creatinine, serum potassium, concomitant disease states, concurrent medications, and documentation of any adverse event that might be related to ACE inhibitor therapy.


RESULTS
There were no significant differences in systolic and diastolic blood pressures, serum creatinine, or serum potassium between enalapril- and lisinopril-treated patients at baseline and after 3 months of therapy. Both treatments resulted in a significant reduction in diastolic blood pressure. There was no significant difference in the incidence of adverse effects between the two treatments. Significantly more patients were dosed on a twice daily regimen of enalapril than lisinopril.


CONCLUSIONS
The data from this retrospective study confirm the safe and effective use of enalapril and lisinopril, two long-acting ACE inhibitors, in elderly hypertensive patients.
Hawkins
D W
DW
University of Georgia, Augusta.
Hall
W D
WD
Douglas
M B
MB
Cotsonis
G
G
D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004656:Enalapril / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D012189:Retrospective Studies
D004656:Enalapril; D017706:Lisinopril