[A retrospective study on the importance of preoperative control in the prognosis of spinocellular carcinoma of the oral cavity].
Surgical treatment of advanced forms of spinocellular carcinoma of the oral cavity (stages 3-4) has been integrated for a number of years with cycles of chemo- and/or radiotherapy both before and after surgery. This chemo-radio-surgical therapeutic protocol consists of four distinct stages, separated by precise treatment-free intervals, which enable the best efficacy to be achieved through synergy. A total of 60 patients were treated by our Ward using this protocol during the period March 1988-June 1992. At the time of surgery a complete negative outcome in the histological picture (pTO) was observed in 40% of cases; lesions had not regressed on only 16% of patients. A retrospective type study has been carried out using Kaplan-Meier's statistical analysis to evaluate the prognostic factors in this population: a significant correlation was found between disease-free time and survival, calculated at 40 months from the completion of the protocol, and histopathological TNM. Non correlation was found with clinical TNM: therefore, rather than the extent of the lesion at the time of diagnosis, its control during preoperative stages appears to be the major prognostic factor.
Pomatto
E
E
Istituto Policattedra di Clinica Odontostomatologica, Università degli Studi di Torino.
Berutto
M
M
Falco
V
V
Bocca
M
M
Vercellino
V
V
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D002945:Cisplatin / Q000627:therapeutic use; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D011300:Preoperative Care; D011379:Prognosis; D011867:Radioisotope Teletherapy; D012189:Retrospective Studies; D013997:Time Factors
D003037:Cobalt Radioisotopes; D002945:Cisplatin; D005472:Fluorouracil
Studio retrospettivo sull'importanza del controllo prechirurgico nella prognosi del carcinoma spinocellulare del cavo orale.