title: Modulation of active avoidance behavior of rats by ICV administration of CGRP antiserum.
abstract: The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum dilution of 1:5 was effective. The present findings suggest that the endogenous CGRP of the brain may be a physiological modulator in extinction processes of active avoidance behavior.
authors.affiliation: Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Kovcs
authors.forename: G
authors.initials: G
authors.lastname: Telegdy
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology* / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology*; D007106:Immune Sera; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007106:Immune Sera; D015740:Calcitonin Gene-Related Peptide