title: The effect of testicular nongerm cell tumors on local spermatogenesis.
abstract: OBJECTIVE
  To assess ipsilateral spermatogenesis in men with malignant and benign nongerm cell tumors of the testis.
  
  
  METHODS
  Histologic review of radical orchiectomy specimens performed for 20 men with malignant nongerm cell tumors and 15 with benign testicular lesions, including five Leydig cell tumors with benign clinical features.
  
  
  METHODS
  Degree of spermatogenesis was determined on a 1 to 10 scale, with 10 representing mature sperm within a seminiferous tubule. For each patient "near" and "far" scores were determined by obtaining the mean score of 50 tubules adjacent (< 3 mm) to the tumor and 50 tubules distant (> 3 mm) from the tumor, respectively.
  
  
  RESULTS
  Total, near, and far scores were all lower for malignant tumors than for benign lesions. Scores for Leydig cell tumors were similar to benign lesions. Malignant tumors demonstrated a gradient effect, with greatest impairment of spermatogenesis occurring adjacent to tumor. In contrast, a distinction between near and far scores was not observed for benign lesions or Leydig cell tumors.
  
  
  CONCLUSIONS
  Malignant nongerm cell tumors of the testis were associated with significant impairment of ipsilateral spermatogenesis, particularly in areas adjacent to tumor. These findings are similar to those observed for testicular germ cell tumors, suggesting a generalized negative influence on ipsilateral spermatogenesis by malignant tumors.
authors.affiliation: Beth Israel Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: G T
authors.initials: GT
authors.lastname: Ho
authors.forename: H
authors.initials: H
authors.lastname: Gardner
authors.forename: K
authors.initials: K
authors.lastname: Mostofi
authors.forename: W C
authors.initials: WC
authors.lastname: DeWolf
authors.forename: K R
authors.initials: KR
authors.lastname: Loughlin
authors.forename: A
authors.initials: A
authors.lastname: Morgentaler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002051:Burkitt Lymphoma / Q000503:physiopathology; D006801:Humans; D007984:Leydig Cell Tumor / Q000503:physiopathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013091:Spermatogenesis; D013736:Testicular Neoplasms / Q000503:physiopathology*