Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats.
We previously found that low-dose X-ray irradiation or radon (weak alpha-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbits. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the age rats to be closer to those in the youth. These findings suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity.
Yamaoka
K
K
Radiation Safety Group, Central Research Institute of Electric Power Industry, Tokyo.
Edamatsu
R
R
Itoh
T
T
Mori
A
A
D000375:Aging / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000528:radiation effects; D002540:Cerebral Cortex / Q000254:growth & development / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008054:Lipid Peroxides / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008560:Membrane Fluidity / Q000502:physiology / Q000528:radiation effects; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism* / Q000528:radiation effects; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014965:X-Rays
D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase