Epstein-Barr virus-associated primary malignant lymphomas of the pleural cavity occurring in longstanding pleural chronic inflammation.
Primary pleural non-Hodgkin's lymphomas (NHLs) have been described mostly in Japan and occasionally in western countries. We report three cases occurring in nonimmunocompromised patients demonstrating close similarities to the Japanese cases. These lymphomas occurred more than 20 years after thoracoplasty for the treatment of pleural or pulmonary tuberculosis. They were all high grade lymphomas of B phenotype (two immunoblastic with plasmocytoid differentiation and one immunoblastic with anaplastic large cells). In situ hybridization (ISH) detected small nuclear RNAs encoded by Epstein-Barr virus (EBERs) in most lymphomatous cells in all cases. This suggests a link between primary pleural lymphoma and the longstanding chronic inflammation, which could favor a clonal evolution of Epstein-Barr virus (EBV)-infected B cells through the production of growth factors or immunosuppressive cytokines produced by inflammatory cells.
Martin
A
A
Service Central d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris.
Capron
F
F
Liguory-Brunaud
M D
MD
De Frejacques
C
C
Pluot
M
M
Diebold
J
J
D000368:Aged; D002908:Chronic Disease; D015870:Gene Expression; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D016393:Lymphoma, B-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008297:Male; D010997:Pleural Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D010998:Pleurisy / Q000150:complications* / Q000209:etiology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2; D016601:RNA-Binding Proteins / Q000235:genetics; D012269:Ribosomal Proteins
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human