Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism.
To assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked the LPS-induced depression of social investigation but had no effect on LPS-induced increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes in dehydrogenase activity of peritoneal macrophages.
Bluthé
R M
RM
INRA-INSERM U394, Bordeaux, France.
Walter
V
V
Parnet
P
P
Layé
S
S
Lestage
J
J
Verrier
D
D
Poole
S
S
Stenning
B E
BE
Kelley
K W
KW
Dantzer
R
R
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000097:blood; D008070:Lipopolysaccharides / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012803:Sick Role; D014628:Vagotomy
D007375:Interleukin-1; D008070:Lipopolysaccharides