title: [Gene therapy. Methods and applications].
abstract: Modern techniques in molecular biology and cell biology will probably make gene therapy, i.e. therapeutic transfer of genes to the patient's cells, available for treatment of many genetic diseases, cancer, cardiovascular diseases and infectious diseases. For genetic diseases the treatment will involve the transfer of a functional copy of the defect gene. The strategy for treatment of cancer may include the transfer of genes that induce the death of cancer cells via toxic molecules, and genes that enhance the immune response to tumour cells. After several years of preclinical studies, the National Institutes of Health in the USA has, up to February 1994, approved 56 protocols for clinical trials in human gene therapy. Most of the protocols include use of viruses to aid gene delivery. This paper briefly reviews the scientific basis for gene therapy, and discusses some clinical applications of somatic gene therapy in humans.
authors.affiliation: Avdeling for Virologi, Statens Institutt for Folkehelse, Oslo.
authors.forename: T O
authors.initials: TO
authors.lastname: Jonassen
authors.forename: B
authors.initials: B
authors.lastname: Grinde
authors.forename: I
authors.initials: I
authors.lastname: Orstavik
mesh_terms: D030342:Genetic Diseases, Inborn / Q000628:therapy; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy; D009369:Neoplasms / Q000628:therapy
vernacular_title: Genterapi. Metoder og anvendelser.