Influence of ethanol on gastric absorption and metabolism of albendazole and mebendazole.
The effect of ethanol administration on gastric absorption in rats of two benzimidazole derivatives has been studied. The ethanol administration was carried out as both acute (5%, 10% and 15% w/v of ethanol in the perfusion solution), and chronic (15, 30 and 120 days) forms. Two benzimidazole derivatives were used: albendazole (ABZ) and mebendazole (MBZ). The administration of ethanol did not affect the kinetic mechanism of the absorption process (simple diffusion) but the absorption rate decreased in all treatments except in 5% acute ethanol, presumably due to the improved solubility of the drugs. Plasma, bile and liver levels after gastric perfusion suggest a possible interference of ethanol metabolism with drug hepatic metabolism.
Justel
A
A
Department of Physiology, Pharmacology and Toxicology, University of Leon, Spain.
Alvarez
A I
AI
Alonso
M L
ML
del Estal
J L
JL
Villaverde
C
C
Barrio
J P
JP
Prieto
J G
JG
D015766:Albendazole / Q000493:pharmacokinetics*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008463:Mebendazole / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
D000431:Ethanol; D008463:Mebendazole; D015766:Albendazole