title: Interleukin-1 beta plasma secretion during diurnal spontaneous and induced sleeping in healthy volunteers.
abstract: We previously reported nocturnal plasma IL-1 beta (beta) increases during sleep in absence of stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis. In this paper we evaluate the presence of plasma IL-1 beta secretion in nine healthy volunteers (mean age 31.2 +/- 4.2) during post-prandial naps, after the administration of zolpidem, a benzodiazepine receptorial agonist. Although a significant increase in IL-1 beta plasma levels during spontaneous sleep was present in only four subjects when compared to those obtained during wake and induced-sleep, spontaneous sleep IL-1 beta mean plasma levels appeared slightly higher than both wake and induced-sleep values. Moreover, a negative correlation was present between IL-1 beta and cortisol (F) values obtained during the early afternoon (r = 7; p < 0.05). Our findings are consistent with a possible association of IL-1 beta secretion to physiologic sleep also during daytime spontaneous naps, with the presence of F influence on this phenomenon, and with the lack of IL-1 beta association to daytime naps after sleep-inducer pharmacological agents.
authors.affiliation: Chair of Neurology I, Medical School University Federico II, Naples, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Covelli
authors.forename: L
authors.initials: L
authors.lastname: D'Andrea
authors.forename: S
authors.initials: S
authors.lastname: Savastano
authors.forename: R
authors.initials: R
authors.lastname: Valentino
authors.forename: A P
authors.initials: AP
authors.lastname: Tommaselli
authors.forename: A
authors.initials: A
authors.lastname: Selleri
authors.forename: F
authors.initials: F
authors.lastname: Massari
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D011725:Pyridines / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology*; D000077334:Zolpidem
chemical_list: D006993:Hypnotics and Sedatives; D007375:Interleukin-1; D011725:Pyridines; D000077334:Zolpidem