Smoking and body weight influence the clearance of chlorpromazine.
The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements from 31 patients. A NONMEM analysis demonstrated that the clearance of CPZ depended on the patient's body weight. Cigarette smoking and cannabis smoking increased the clearance of CPZ. Chronic alcohol consumption and the concurrent use of anticholinergics did not appear to influence the clearance of CPZ significantly.
Chetty
M
M
Drug Studies Unit, University of Durban-Westville, South Africa.
Miller
R
R
Moodley
S V
SV
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D002746:Chlorpromazine / Q000493:pharmacokinetics*; D002908:Chronic Disease; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism; D012737:Sex Factors; D012907:Smoking / Q000378:metabolism*
D000431:Ethanol; D002746:Chlorpromazine