Lack of a pharmacokinetic interaction between ciprofloxacin and fenbufen.
The possible effects of a three day pretreatment with fenbufen on the pharmacokinetics of a single oral (500 mg) dose of ciprofloxacin were evaluated in a randomized crossover study in a group of eight healthy male volunteers. Fenbufen pretreatment was shown to have no significant effect on ciprofloxacin pharmacokinetics.
Kamali
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Wolfson Unit of Clinical Pharmacology, University of Newcastle, U.K.
D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D010654:Phenylbutyrates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010654:Phenylbutyrates; D002939:Ciprofloxacin; C010725:fenbufen