Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma.
The potential role of angiotensin-II in mediating catecholamine and neuropeptide-Y release in a human pheochromocytoma has been investigated. Angiotensin-II type I receptors are transcribed and translated into functional proteins in a surgically removed pheochromocytoma. Primary cell culture of the tumor has been studied in a perfused system. Angiotensin-II increased the release of norepinephrine and neuropeptide-Y by the pheochromocytes. Activation of the angiotensin-II type I receptors by angiotensin-II was associated with a rise in cytosolic free calcium. The renin-angiotensin system may, therefore, contribute to the secretion of catecholamines and NPY occurring in patients with pheochromocytoma and when stimulated trigger hypertensive crisis.
Grouzmann
E
E
Division d'Hypertension, CHUV, Lausanne, Switzerland.
Werffeli-George
P
P
Fathi
M
M
Burnier
M
M
Waeber
B
B
Waeber
G
G
D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010477:Perfusion; D010673:Pheochromocytoma / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D014407:Tumor Cells, Cultured
D009478:Neuropeptide Y; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D002118:Calcium; D009638:Norepinephrine