Cardiac electric activity of 1-(2-[(6-methoxyl)-naphthylmethyl])-1-methyl-N-piperidinylacethyl-6,7- dimethoxyl-1,2,3,4-tetrahydroisoquinoline in SHR and WKY rats.
1-(2-[(6-Methoxyl)-naphthylmethyl)])-1-methyl-N-piperidinylacethyl -6,7- dimethoxyl-1,2,3,4-tetrahydroisoquinoline (CPU-23), a substituted tetrahydroisoquinoline, reduced the voltages of P wave and J point, prolonged PR interval, and slowed sinus rhythm of ECG in spontaneously hypertensive rats (SHR) and age-matched normotensive WKY rats. The effects of CPU-23 on cardiac electric activity were stronger in SHR than in WKY rats (P < 0.05 or P < 0.01). The results suggest that CPU-23 have a calcium antagonistic activity on rat hearts and that calcium antagonists may exert a stronger inhibition of the cardiac electric activity in hypertensive rats than in normotensive rats.
Dong
H
H
Department of Biophysics, School of Basic Medical Sciences, Shanghai Medical University, China.
Liang
Z J
ZJ
Yang
Z C
ZC
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007546:Isoquinolines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D044005:Tetrahydroisoquinolines
D002121:Calcium Channel Blockers; D007546:Isoquinolines; D010880:Piperidines; D044005:Tetrahydroisoquinolines; C077683:CPU 23