Effects of benzamide derivatives on dopamine release from striatal slices of rats.
The effects of the benzamide derivatives, (-)-sulpiride, sultopride and nemonapride, on spontaneous and electrically evoked dopamine (DA) release from striatal slices of rats were investigated. Nemonapride at concentrations of 100 nM or higher caused a dose-dependent increase in spontaneous DA release from the slices. (-)-Sulpiride and sultopride had little effect on spontaneous DA release. The electrically evoked DA release was enhanced by (-)-sulpiride at concentrations of 100 nM or higher in the superfusate and reduced by nemonapride at 100 nM or higher. Sultopride caused a small increase in the evoked release of DA. The different activities of these drugs on DA release may account for the different clinical results they produce.
Yamada
S
S
Department of Pharmacology, Kurume University School of Medicine, Japan.
Yokoo
H
H
Nishi
S
S
D000077582:Amisulpride; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000494:pharmacology*
D001549:Benzamides; D011759:Pyrrolidines; D013469:Sulpiride; D000077582:Amisulpride; C030265:nemonapride; D004298:Dopamine