Protein folding dynamics: the diffusion-collision model and experimental data.
The diffusion-collision model of protein folding is assessed. A description is given of the qualitative aspects and quantitative results of the diffusion-collision model and their relation to available experimental data. We consider alternative mechanisms for folding and point out their relationship to the diffusion-collision model. We show that the diffusion-collision model is supported by a growing body of experimental and theoretical evidence, and we outline future directions for developing the model and its applications.
Karplus
M
M
Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.
Weaver
D L
DL
D004058:Diffusion; D007700:Kinetics; D008433:Mathematics; D008956:Models, Chemical; D017510:Protein Folding; D017433:Protein Structure, Secondary; D013816:Thermodynamics