title: [Benzimidazole derivatives with antihypertensive and platelet antiaggregant actions].
abstract: The changing of the chemical structure of 2-benzylbenzimidazole, the active substance of Dibazol (Tromesedan), generated five analogous structures. Two salts of the same active substance have been synthesized in view of improving some of the pharmacological and toxicological features. The results of the anti-AHT and platelet aggregation actions are also presented.
authors.affiliation: Disciplina Chimie farmaceutică, Universitatea de Medicină şi Farmacie Iaşi.
authors.forename: G
authors.initials: G
authors.lastname: Rusu
authors.forename: G
authors.initials: G
authors.lastname: Dănilă
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000633:toxicity; D001562:Benzimidazoles / Q000494:pharmacology* / Q000633:toxicity; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D010975:Platelet Aggregation Inhibitors
vernacular_title: Derivaţi ai benzimidazolului cu acţiune antihipertensivă şi antiagregant-plachetară.