title: The relationship between cocaine-induced paranoia and compulsive foraging: a preliminary report.
abstract: Two prominent behavioral syndromes associated with chronic cocaine use that have been described in the literature are cocaine-induced paranoia (CIP) and cocaine-induced compulsive foraging (CICF) for cocaine. To help to clarify the relationship between the two cocaine-induced syndromes, the concordance and sequence of onset of the two cocaine-induced behaviors over the course of the patients' lifetime use of cocaine and during the course of a binge was examined in 62 crack cocaine-dependent men. Thirty-four (54.8%) reported experiencing both CIP and CICF. In 18 (29%) of the patients, only one of these cocaine-induced behavioral syndromes was reported. Ten (16.1%) of the subjects reported neither CIP nor CICF. Patterns of cocaine or other substance use and degrees of tolerance to cocaine were not significantly different between the groups endorsing different patterns of cocaine-induced behaviors. CIP typically preceded the onset of CICF both over the course of the patients' lifetime use of cocaine and over the course of a binge. The study results suggest varying thresholds for the expression of these behaviors in chronic cocaine-abusing individuals.
authors.affiliation: Department of Veterans Affairs Medical Center, Psychiatry Service, Washington, DC 20422.
authors.forename: R B
authors.initials: RB
authors.lastname: Rosse
authors.forename: M
authors.initials: M
authors.lastname: Fay-McCarthy
authors.forename: J P
authors.initials: JP
authors.lastname: Collins
authors.forename: T N
authors.initials: TN
authors.lastname: Alim
authors.forename: S I
authors.initials: SI
authors.lastname: Deutsch
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects; D003042:Cocaine / Q000009:adverse effects* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000209:etiology*; D010259:Paranoid Disorders / Q000209:etiology*; D012701:Serotonin / Q000378:metabolism; D019966:Substance-Related Disorders / Q000523:psychology*
chemical_list: D012701:Serotonin; D003042:Cocaine; D004298:Dopamine