Modulation of active avoidance behavior of rats by ICV administration of CGRP antiserum.
The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum dilution of 1:5 was effective. The present findings suggest that the endogenous CGRP of the brain may be a physiological modulator in extinction processes of active avoidance behavior.
Kovcs
A
A
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Telegdy
G
G
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology* / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology*; D007106:Immune Sera; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007106:Immune Sera; D015740:Calcitonin Gene-Related Peptide