title: Differential effects of prostanoid synthesis inhibitors on cicletanine-induced relaxation of isolated human epigastric arteries.
abstract: We have examined the influence of prostanoid synthesis inhibitors on the relaxation responses induced by cicletanine in ring preparations of isolated human epigastric arteries following precontraction induced by 10(-7) M noradrenaline. Cicletanine caused concentration-dependent relaxations, uninfluenced by the cyclooxygenase inhibitors, meclofenamate (1, 10 microM) and indomethacin (1, 10 microM) but significantly (p < 0.05) attenuated by the specific prostacyclin synthesis inhibitor, tranylcypromine (0.1-10 microM) (n > 6 in each). In contrast, cromakalim-induced relaxations were significantly attenuated by indomethacin, meclofenamate and tranylcypromine. The tranylcypromine-sensitive cicletanine-induced relaxation suggests, at least in part, the involvement of prostacyclin in the vasodilator action of cicletanine.
authors.affiliation: Department of Physiology, College of Health Sciences, University of Benin, Nigeria.
authors.forename: A B
authors.initials: AB
authors.lastname: Ebeigbe
authors.forename: A
authors.initials: A
authors.lastname: Oguogho
authors.forename: A D
authors.initials: AD
authors.lastname: Ighoroje
authors.forename: C P
authors.initials: CP
authors.lastname: Aloamaka
mesh_terms: D000009:Abdominal Muscles / Q000098:blood supply*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D001578:Benzopyrans / Q000494:pharmacology; D019806:Cromakalim; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008469:Meclofenamic Acid / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology; D014191:Tranylcypromine / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D001578:Benzopyrans; D016861:Cyclooxygenase Inhibitors; D011725:Pyridines; D011758:Pyrroles; D019806:Cromakalim; D014191:Tranylcypromine; D008469:Meclofenamic Acid; C038068:cicletanine; D009638:Norepinephrine; D007213:Indomethacin