title: ["Neuroadaptation" in long-term cannabis abuse. A clinical and electroencephalographic case study].
abstract: This report is about electroencephalographic changes in a twenty-eight year old patient with longterm heavy cannabis use. He was admitted to our hospital after he had developed a depressive-apathetic syndrome. Two days after the last cannabis-intake, the patient had recovered from initial psychopathology and his EEG was completely inconspicuous at this day. Some days later however the patient's behavior became increasingly impulsive and unstable, while his EEG showed a marked disturbed regulation of vigilance. In the following weeks his impulsiveness became less and his EEG returned to normal. We suggest that these alterations may reflect a discontinuation of the initial neuroadaption of the central nervous system to the drug.
authors.affiliation: Psychiatrische Klinik und Poliklinik, Freien Universität Berlin.
authors.forename: G
authors.initials: G
authors.lastname: Winterer
authors.forename: L G
authors.initials: LG
authors.lastname: Schmidt
authors.forename: K
authors.initials: K
authors.lastname: Frick
authors.forename: G
authors.initials: G
authors.lastname: Ulrich
mesh_terms: D000328:Adult; D000513:Alpha Rhythm; D002186:Cannabinoids / Q000009:adverse effects; D003866:Depressive Disorder / Q000139:chemically induced / Q000503:physiopathology / Q000534:rehabilitation; D004361:Drug Tolerance; D004569:Electroencephalography / Q000187:drug effects*; D005500:Follow-Up Studies; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000503:physiopathology* / Q000534:rehabilitation; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000534:rehabilitation
chemical_list: D002186:Cannabinoids
vernacular_title: "Neuroadaptation" bei langjährigem Cannabiskonsum. Eine klinische und elektroenzephalographische Fallbeobachtung.