title: Small-amplitude pressure oscillations do not modify respiratory mechanics in rabbits.
abstract: Changes in respiratory mechanics have occasionally been observed during high-frequency ventilation. In this study we investigated whether small pressure oscillations such as those used for respiratory impedance measurements modified total respiratory resistance (Rrs) and total respiratory elastance (Ers). The latter were measured in six paralyzed artificially ventilated rabbits with and without superimposed pressure oscillations at the airway opening. Rrs and Ers were obtained by least square fitting of low-pass filtered tracheal pressure and flow to the usual first-order model. Pressure oscillations of 2-4 hPa peak-to-peak at 10, 20, and 30 Hz applied for periods of 10 min had virtually no effect on Ers (changes ranging from -2.5 to 2.6%) and Rrs (0-8.2%). Analysis of variance did not show a significant difference on the pooled data. Pressure oscillations were also applied every other minute after a histamine aerosol. Ers and Rrs were similarly unchanged. We conclude that the small pressure oscillations used in respiratory impedance measurements do not modify lung mechanical properties and lung response to bronchomotor agents.
authors.affiliation: Unité 14 de Physiopathologie Respiratoire, Institut Natinal de la Santé et de la Recherche Médicale, Vandoeuvre-les-Nancy, France.
authors.forename: R
authors.initials: R
authors.lastname: Peslin
authors.forename: C
authors.initials: C
authors.lastname: Saunier
authors.forename: C
authors.initials: C
authors.lastname: Gallina
authors.forename: C
authors.initials: C
authors.lastname: Duvivier
mesh_terms: D000399:Air Pressure; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D006632:Histamine / Q000494:pharmacology; D008170:Lung Compliance / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D011817:Rabbits; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*
chemical_list: D006632:Histamine