title: [Acute myopathy related to the administration of glucocorticoids and neuromuscular blockers].
abstract: Two cases of acute myopathy following the administration of high doses of glucocorticoids in patients requiring mechanical ventilation and who were also administered neuromuscular blockers are presented. The patients were two women of 57 and 73 years of age. The doses of methylprednisolone administered were of 810 and 1,180 mg during the first 7 and 17 days, respectively. With regard to the total doses of neuromuscular blockers the first patient received 76 mg of pancuronium over 4 days while the second received 1,180 mg of atracurium over 17 days. This myopathy is characterized by a clinical and histological picture which differs from that associated to the chronic use of glucocorticoids being attributed to a toxic action of these drugs somewhat favored by immobilization due to the use of neuromuscular blockers. Given the lack of references in the literature on this entity in Spain a review was undertaken with the need for correct early diagnosis allowing differentiation from other causes of weakness such as ischemia of the cerebral trunk, polyradiculoneuritis and polyneuritis of critical patients being of note. Muscular biopsy is therefore very useful since very suggestive signs of this myopathy may be found. The disease is reversible with no effective treatment. An early rehabilitation program is the only method of shortening the convalescence period.
authors.affiliation: Servcios de Medicina Interna, General y Neumologia Hospital Clinic i Provincial, Barcelona.
authors.forename: O
authors.initials: O
authors.lastname: Miró
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
authors.forename: P
authors.initials: P
authors.lastname: Nadal
authors.forename: C
authors.initials: C
authors.lastname: Picado
authors.forename: V
authors.initials: V
authors.lastname: Plaza
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Márquez
mesh_terms: D000208:Acute Disease; D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced*; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*
chemical_list: D005938:Glucocorticoids; D009466:Neuromuscular Blocking Agents
vernacular_title: Miopatía aguda en relación con la administración de glucocorticoides y bloqueadores neuromusculares.