Immune status and booster effects of low doses of tetanus toxoid in Swedish medical personnel.
Of 102 medical staff at a Swedish hospital, 81% had tetanus antitoxin titres > or = 0.01 IU/ml in 1984-85. The unprotected individuals (antitoxin titre < 0.01 IU/ml) were all > 30 years of age. Of this group, one-third lacked a protective antibody level against tetanus toxin. Low booster doses of tetanus toxoid (0.75 or 1.9 Lf) were given to 66 vaccinees with a history of previous basic vaccination and no history of booster vaccination within the previous 5 years. The median titre increased from 0.26 IU/ml before to 3.3 IU/ml after vaccination. Low doses of tetanus toxoid may thus still provide an adequate immune response when given as a booster vaccination to individuals with a reliable history of basic immunization.
Björkholm
B
B
Department of Infectious Diseases, Göteborg University, Ostra Hospital, Sweden.
Wahl
M
M
Granström
M
M
Hagberg
L
L
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000009:adverse effects; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007109:Immunity; D007117:Immunization, Secondary; D008297:Male; D008505:Medical Staff, Hospital; D008875:Middle Aged; D013548:Sweden; D013742:Tetanus / Q000276:immunology / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D013745:Tetanus Toxoid