[Intensity of lipid peroxidation in the small intestinal wall in peritonitis and its correction].
Experiments were conducted on albino rats to study lipid peroxidation (LPO) in muscle homogenates of the small intestine in peritonitis of various duration. LPO increased most significantly in 24-hour peritonitis. There was no statistically significant difference between the LPO values two days later and those of 24-hour peritonitis. With the use of the antioxidant alpha-tocopherol with essential 12 hours after the development of peritonitis no significant changes occurred in the LPO values. In 24-hour peritonitis LPO was initiated but it was less pronounced. alpha-Tocopherol acetate and essential were included in the complex of therapeutic measures in 20 patients. They were administered before and 3-4 days after the operation. As a result the motor-evacuation function of the gastrointestinal tract was restored in a shorter time. The postoperative period took a favorable course, and the duration of in-hospital treatment reduced by 2-3 days on the average.
Diachuk
I A
IA
Benedikt
V V
VV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010538:Peritonitis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010713:Phosphatidylcholines / Q000494:pharmacology / Q000627:therapeutic use*; D011182:Postoperative Care; D011300:Preoperative Care; D051381:Rats; D016896:Treatment Outcome; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D010713:Phosphatidylcholines; C011246:essential 303 forte; D014810:Vitamin E
Intensivnost perekisnogo okisleniia lipidov v stenke tonkoĭ kishki pri peritonite i eë korrektsiia.