Domestic cases of hemorrhagic fever with renal syndrome in the United States.
Although serologic studies have identified hantaviral infection in the United States, acute disease has not been recognized. This study describes 3 cases of domestically acquired hemorrhagic fever with renal syndrome (HFRS) in the United States. Infection was due to a local strain of Seoul virus (Baltimore rat virus). A review of the clinical features indicated a mild illness characterized by nausea, vomiting, renal and liver failure similar to HFRS described elsewhere for rat-borne viruses. Follow-up of 2 patients identified persistent hypertension and renal disease providing further evidence of an association between past hantaviral infection and hypertensive renal disease.
Glass
G E
GE
Department of Immunology and Infectious Diseases, Johns Hopkins School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
Watson
A J
AJ
LeDuc
J W
JW
Childs
J E
JE
D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D018063:Hantaan virus / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000821:virology; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014481:United States / Q000453:epidemiology
D000914:Antibodies, Viral