title: Isolation, characterization and protection studies in mice of a streptomycin-dependent mutant of Streptococcus suis type 1/2.
abstract: An avirulent, streptomycin-dependent (Str-D) mutant of Streptococcus suis type 1/2 was produced and characterized by its antimicrobial susceptibility, growth kinetics, biochemical reactions and reversion rate. Homologous and heterologous vaccine trials in mice resulted in complete protection against challenge with S. suis types 1 and 1/2 and partial protection against challenge with S. suis type 2.
authors.affiliation: Department of Pathology and Microbiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
authors.forename: N
authors.initials: N
authors.lastname: Foster
authors.forename: J J
authors.initials: JJ
authors.lastname: Staats
authors.forename: M M
authors.initials: MM
authors.lastname: Chengappa
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D009154:Mutation; D010641:Phenotype; D013290:Streptococcal Infections / Q000517:prevention & control*; D017011:Streptococcus suis / Q000187:drug effects / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D013307:Streptomycin / Q000494:pharmacology*; D014611:Vaccination
chemical_list: D001428:Bacterial Vaccines; D013307:Streptomycin