title: Heparin-surface-modified intraocular lens implantation in eyes with pseudoexfoliation syndrome.
abstract: Eyes with pseudoexfoliation syndrome have a greater risk of intraoperative and postoperative complications. Clinical and histopathological studies indicate that heparin-surface-modified intraocular lenses (HSM IOLs) can reduce postoperative anterior segment inflammation. Our study evaluated the blood-aqueous barrier permeability in eyes with pseudoexfoliation syndrome and implanted with an HSM IOL. We examined two groups of 20 patients, one comprising patients with pseudoexfoliation syndrome and one a sex- and age-matched control group with senile cataracts. Each group was divided into two subgroups of ten patients each. In one subgroup, an HSM IOL was implanted; in the other, a conventional poly(methyl methacrylate) IOL. We performed a complete ophthalmologic examination and iris angiography preoperatively and at 30, 90, and 180 days after surgery. Fluorophotometry was performed at the 90-day and 180-day postoperative examinations. The patients with pseudoexfoliation syndrome had a higher blood-aqueous barrier permeability than did the control group. Permeability decreased significantly three and six months after surgery, especially in the HSM IOL group.
authors.affiliation: Eye Clinic, University of Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ravalico
authors.forename: D
authors.initials: D
authors.lastname: Tognetto
authors.forename: F
authors.initials: F
authors.lastname: Baccara
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism; D001693:Biological Transport, Active; D001769:Blood / Q000378:metabolism; D002387:Cataract Extraction; D002463:Cell Membrane Permeability / Q000502:physiology; D017889:Exfoliation Syndrome / Q000150:complications* / Q000503:physiopathology; D005260:Female; D015590:Fluorophotometry; D006493:Heparin; D006801:Humans; D007498:Iris / Q000098:blood supply; D007910:Lenses, Intraocular; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D014792:Visual Acuity
chemical_list: D008768:Methylmethacrylates; D020366:Methylmethacrylate; D006493:Heparin