Sex difference in the feeding responses of non-deprived rats to the 5-HT1A agonists 8-OH-DPAT and gepirone.
The aim of this study was to determine whether there was any difference in the feeding responses of male and female rats to the 5-HT1A agonists 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) and gepirone. 8-OH-DPAT (62.5 and 500 mcg/kg, s.c.) and gepirone (1, 2 and 4 mg/kg, s.c.) significantly increased the amount of food consumed by non-deprived male rats (p < 0.01 in each case) over a 2 h period. Similar doses of 8-OH-DPAT and gepirone had no effects on food intake in non-deprived female rats. However, a higher dose of gepirone (i.e., 8 mg/kg, s.c.) significantly increased feeding (p < 0.01) in non-deprived female rats. These results thus show a clear-cut sex difference in the sensitivity of non-deprived rats to the hyperphagic effects of 5-HT1A agonists.
Ebenezer
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School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.
Tite
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005260:Female; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D012727:Sex Characteristics; D013268:Stimulation, Chemical
D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C039979:gepirone