Reassessment of an apparent t(12;17)(p11;p11) as an unbalanced t(17;21)(p11;q11) in a case of B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization.
We report a published case of chronic lymphocytic leukemia (CLL) in which conventional cytogenetic analysis supported the presence of an unbalanced t(12;17)(p11;p11). However, fluorescence in situ hybridization (FISH) analysis, with specific DNA libraries from chromosomes 17 and 21 (chromosome painting), demonstrated that the translocation was actually an unbalanced t(17;21)(p11;q11).
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Laboratoire de Génétique Humaine, Faculté de Médicine, C.H.R.U., Lille, France.
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Fenaux
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D000368:Aged; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D014178:Translocation, Genetic