Effects of a diet restricted in saturated fatty acids and cholesterol on the composition of apolipoprotein A-I--containing lipoprotein particles in the fasting and fed states.
To test the hypothesis that diet may exert differential effects on apolipoprotein (apo) A-I--containing high-density-lipoprotein (HDL) particles with (w) and without (w/o) apo A-II [Lp(A-I w A-II) and Lp(A-I w/o A-II)], the effects of a diet low in saturated fatty acids and cholesterol [National Cholesterol Education Panel (NCEP) Step 2 diet] on these lipoproteins were determined in eight normolipidemic subjects, aged 53-74 y, in both the fasting and nonfasting states. Compared with a diet high in saturated fatty acid and cholesterol, consumption of an NCEP diet (6 mo) lowered fasting plasma, low-density-lipoprotein, and HDL cholesterol, and nonfasting plasma cholesterol, triglyceride, and HDL cholesterol (P < 0.05- < 0.005). Phospholipid in fasting and nonfasting Lp(A-I w A-II) and Lp(A-I w/o A-II) was lower during the NCEP diet (P < 0.05-0.001), but reductions in apo A-I or A-II were observed only in Lp(A-I w A-II). In contrast, differences in particle-size profiles were detected in Lp(A-I w/o A-II) but not in Lp(A-I w A-II). These observations provide further evidence that Lp(A-I w A-II) and Lp(A-I w/o A-II) are distinct metabolic entities.
Cheung
M C
MC
Northwest Lipid Research Laboratories, Department of Medicine, University of Washington, Seattle 98103.
Lichtenstein
A H
AH
Schaefer
E J
EJ
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000378:metabolism*; D016633:Apolipoprotein A-II / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D005215:Fasting; D005227:Fatty Acids / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005227:Fatty Acids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol