title: Increased level of serum HLA class I antigens in HIV infection. Correlation with disease progression.
abstract: Analysis of (sHLA-I) antigens in a large number of HIV-positive subjects found a significant increase of their level, but did not detect any change in their molecular profile. Monitoring at yearly intervals for four years of the sHLA-I antigen level in 14 HIV-positive subjects with a normal sHLA-I antigen level at study entry showed a significant correlation between progressive increase of sHLA-I antigen level and disease progression. Furthermore, a Kaplan-Meier plot of the frequency of development of AIDS in 34 patients whose cases were followed for 7 years showed that sHLA-I antigen level is a strong predictor of progression to AIDS. Its predictive value is comparable to that of serum beta 2-mu level, greater than that of serum neopterin, and lower than that of CD4+ T-cell percentage. The predictive value of sHLA-I antigen level in combination with serum beta 2-mu level, neopterin level, or CD4+ T-cell percentage is greater than that of each individual variable. These results suggest that measurement of the sHLA-I antigen level may provide useful prognostic information in HIV-positive subjects.
authors.affiliation: Department of Internal Medicine, Medical School, University of Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Puppo
authors.forename: S
authors.initials: S
authors.lastname: Brenci
authors.forename: L
authors.initials: L
authors.lastname: Lanza
authors.forename: O
authors.initials: O
authors.lastname: Bosco
authors.forename: M A
authors.initials: MA
authors.lastname: Imro
authors.forename: M
authors.initials: M
authors.lastname: Scudeletti
authors.forename: F
authors.initials: F
authors.lastname: Indiveri
authors.forename: S
authors.initials: S
authors.lastname: Ferrone
mesh_terms: D018791:CD4 Lymphocyte Count; D002478:Cells, Cultured; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood*; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans; D015151:Immunoblotting; D011233:Precipitin Tests
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I