[Guillain-Barré syndrome].
Sera from patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni infection have autoantibody to GM1 ganglioside in the acute phase of the illness. There is a strong association between GBS and Penner's serotype 19 (PEN 19) of C. jejuni. The terminal structure of the bacterial lipopolysaccharide is identical to the terminal tetrasaccharide of GM1 ganglioside. Anti-GM1 antibody inhibits motoneuron excitability. Molecular mimicry between infectious agents and nerve tissue components may function in the development of GBS.
Yuki
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Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University.
D002169:Campylobacter Infections / Q000150:complications*; D016123:Campylobacter jejuni / Q000276:immunology*; D002240:Carbohydrate Sequence; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D011129:Polyradiculoneuropathy / Q000276:immunology*
D005732:Gangliosides