title: Complete remission of metastasized adrenocortical carcinoma under o,p'-DDD.
abstract: The case of a 53 year old female patient with metastasized androgen producing adrenocortical carcinoma is presented. After initial adrenalectomy a local relapse had been treated by surgery and external irradiation. Solitary liver metastases had been resected repeatedly. Subsequently multiple liver metastases required systemic chemotherapy. Treatment with o,p'-DDD (initially 12 g/d, long term treatment 1.5-3 g/d) has resulted in a complete remission for nearly 4 years. Gastrointestinal side effects occurred initially but subsided with dose reduction of o,p'-DDD.
authors.affiliation: Abteilung für Endokrinologie und Rheumatologie, Heinrich Heine Universität, Düsseldorf, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Kornely
authors.forename: R
authors.initials: R
authors.lastname: Schlaghecke
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D000315:Adrenalectomy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D008939:Mitotane / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D008939:Mitotane