title: [Pancreatic endocrine F-cell tumor].
abstract: Two cases of pancreatic F-cell malignant tumors, producing only pancreatic polypeptide (PP) with clinical, biochemical and immunohistochemical features are described. No PP-associated endocrine symptoms were present. In both tumors, definitive diagnosis was immunohistochemical, and surgical treatment was carried out. Clinical evolution in the two patients was different: one of them died within the postoperative period with upper gastrointestinal bleeding by multiple duodenal ulcers, whereas the other--with lymph node metastasis at intraoperative diagnosis--is alive six years after treatment. F-cell tumors can be classified among the group of silent endocrine tumors of the pancreas. The reason for their discrepancy in the clinical behavior is unknown.
authors.affiliation: Universidad de Milán, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Fuertes Guiró
authors.forename: G
authors.initials: G
authors.lastname: Mortara
authors.forename: E
authors.initials: E
authors.lastname: Schiaffino
authors.forename: C
authors.initials: C
authors.lastname: d'Urbano
mesh_terms: D000368:Aged; D018273:Carcinoma, Islet Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010191:Pancreatic Polypeptide / Q000378:metabolism; D013156:Splenectomy
chemical_list: D010191:Pancreatic Polypeptide
vernacular_title: Tumor pancreático endocrino de células F.