[Effects of sennosides on cellular electric activities in smooth muscle cells of guinea pig taenia coli].
The effects of sennosides (Sen, an extract of Chinese rhubarb) on cellular spontaneous electric activities of guinea pig taenia coli were studied by intracellular microelectrode technique. Sen 0.1-20 mmol.L-1 improved the depolarization of cell membrane, quickened the burst of slow wave potential, and increased notably the frequency of spike potentials. Sen (20 mmol.L-1) induced spontaneous spike potentials. These results provide direct evidence for the enhancing effect of Sen on intestinal peristalsis at cellular level.
Yang
W X
WX
Department of Physics, Nankai University, Tianjin, China.
Jin
Z G
ZG
Xu
W S
WS
Tian
Z S
ZS
Guo
S D
SD
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D003106:Colon / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology*; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D000081226:Sennosides; D012676:Senna Extract