[A study of intra-arterial infusion with carboplatin (CBDCA) for 2 patients with maxillary gingival cancer].
In 2 cases of squamous cell carcinoma of maxillary gingiva, carboplatin (CBDCA) was administered by continuous infusion for 5 days, and the clinical outcome and platinum concentrations in the peripheral blood, urine and tissue were investigated. Clinical effects were PR in one of the 2 cases and CR in the other. Platinum concentrations were as high as 3.17 and 13.90 micrograms/g in the tissue, but low in peripheral blood, not exceeding 0.61 and 0.62 micrograms/ml, respectively. These findings suggested that the present method secures the transport of the agent to a local site, with possible reduction of side effects.
Susami
E
E
Dept. of Dentistry and Oral Surgery, School of Medicine, Keio University.
Uchiyama
K
K
Asanami
S
S
D000368:Aged; D016190:Carboplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005887:Gingival Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008437:Maxilla; D010984:Platinum / Q000032:analysis
D010984:Platinum; D016190:Carboplatin