[The role of pentoxifylline in acute lung injury complicated by pancreatitis].
Caerulein-induced acute pancreatitis in rats commonly complicated ARDS-like acute lung injury. Acute pancreatitis induced by caerulein in the circulating neutrophil-depleted rat by hydroxyrea or with the administration of SOD, CAT or Pentoxifylline, the wet lung weight, lung capillary endothelial permeability decrease significantly compared to the caerulein group (P < 0.05). There are no lung morphologic evidences of neutrophil sequestration, interstial edema, intralveolar hemorrhage that seen in caerulein infusion animals. But it has no effect against the development of acute pancreatitis. It suggested that neutrophil and neutrophil-derived oxygen radical are the important mediators of acute lung injury complicated by pancreatitis.
Peng
X X
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Department of Pulmonary Medicine, Rui Jin Hospital, Shanghai Second Medical University.
Deng
W W
WW
Huang
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SG
D000818:Animals; D002199:Capillary Permeability; D002108:Ceruletide; D005609:Free Radicals; D008297:Male; D009504:Neutrophils; D010195:Pancreatitis / Q000139:chemically induced / Q000150:complications*; D010431:Pentoxifylline / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy*
D005609:Free Radicals; D002108:Ceruletide; D010431:Pentoxifylline