title: Cororubicin, a new anthracycline antibiotic generating active oxygen in tumor cells.
abstract: In the course of our screening for antitumor antibiotics which show biological activities by generating active oxygen in tumor cells. Micromonospora sp. JY16 was found to produce a new anthracycline antibiotic designated cororubicin. The structure of cororubicin was elucidated as shown in Fig. 5 on the basis of NMR spectral analysis. Cororubicin generated superoxide radicals in tumor cells and showed cytotoxicity, which was reduced by addition of an antioxidative agent, dithiothreitol (DTT).
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishigami
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D005609:Free Radicals; D006801:Humans; D007624:KB Cells / Q000378:metabolism; D008847:Micromonospora / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D005609:Free Radicals; D013481:Superoxides; C091117:cororubicin; D004229:Dithiothreitol