[The effect of 764-3 on platelet aggregation and the activity of enzymes in arachidonic acid metabolism].
764-3 is a purified compound extracted from Chinese herb Salvia miltiorrhizae. It was found to inhibit human and rabbit platelet aggregation induced by AA or ADP. Using AA as the substrate and pig lung microsome to provide enzymes, low doses of 764-3 (5-100 micrograms/ml) promoted the generation of 6-keto-PGF1 alpha in a dose-dependent manner. At a dose of 500 micrograms/ml, both TXB2 and 6-keto-PGF1 alpha production were inhibited. The results suggest that low dose of 764-3 may be able to bring a balance between TXB2 and 6-keto-PGF1 alpha.
Wang
Z
Z
Institute of Basic Medical Sciences, CAMS and PUMC, Beijing.
Zhang
H
H
You
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H
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013552:Swine; D013929:Thromboxane B2 / Q000096:biosynthesis
D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha