title: Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.
abstract: We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess. Two courses of tinidazole (the second in combination with percutaneous aspiration of the abscess) were required to achieve cure.
authors.affiliation: Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, New South Wales, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Lawford
authors.forename: T C
authors.initials: TC
authors.lastname: Sorrell
mesh_terms: D000328:Adult; D000562:Amebiasis / Q000188:drug therapy / Q000209:etiology*; D001259:Ataxia; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D006801:Humans; D008101:Liver Abscess, Amebic / Q000150:complications / Q000188:drug therapy; D008297:Male; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D013158:Splenic Diseases / Q000188:drug therapy / Q000469:parasitology*; D014011:Tinidazole / Q000627:therapeutic use
chemical_list: D014011:Tinidazole; D008795:Metronidazole