Phosphoinositide metabolism in airway smooth muscle.
Agonist-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate, which generates inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol, is thought to be one of the major mechanisms underlying pharmacomechanical coupling in airway smooth muscle. This article is a review of the currently available information on phosphoinositide and inositol 1,4,5-trisphosphate metabolism in this tissue and includes data on inositol 1,4,5-trisphosphate-induced Ca2+ release and the receptor mediating this effect. The final section outlines the potential mechanisms underlying physiological regulation of phosphoinositide metabolism by other second-messenger pathways operative in this tissue.
Chilvers
E R
ER
Department of Medicine (RIE), Rayne Laboratory, University of Edinburgh, Medical School, U.K.
Lynch
B J
BJ
Challiss
R A
RA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000819:agonists / Q000378:metabolism*; D011493:Protein Kinase C / Q000494:pharmacology; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism*; D015290:Second Messenger Systems
D010716:Phosphatidylinositols; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D017869:Cyclic GMP-Dependent Protein Kinases; D011493:Protein Kinase C; D006152:Cyclic GMP; D002118:Calcium