Antinuclear antibodies in patients with atopic dermatitis and severe facial lesions.
BACKGROUND
In adult patients with atopic dermatitis (AD), the presence of autoantibodies such as anti-IgE and antinuclear antibodies (ANA) has been demonstrated. The patients may have altered immune regulation.


OBJECTIVE
The purpose of this study is to examine the prevalence of ANA in AD patients with severe facial eruptions and to evaluate the differences between ANA-positive and ANA-negative AD patients.


METHODS
ANA, blood eosinophil count, total serum IgE levels, specific IgE antibody to Dermatophagoides pteronyssinus, disease duration, photosensitivity and association with respiratory allergic diseases were checked in 89 AD patients.


RESULTS
Twenty-three (25.8%) AD patients showed positive ANA at titers ranging from 1:40 to 1:640, and the incidence of positive ANA was 12.1% in controls. Twenty-five (71.4%) of 35 AD patients with positive ANA at titers ranging from 1:20 to 1:640 were females.


CONCLUSIONS
Adult AD patients with severe facial lesions should be examined for serum ANA. Particularly in female and photosensitive AD patients with severe facial lesions, serum autoantibodies have to be carefully investigated to differentiate from autoimmune diseases.
Tada
J
J
Department of Dermatology, Okayama University Medical School, Japan.
Toi
Y
Y
Yoshioka
T
T
Fujiwara
H
H
Arata
J
J
D000293:Adolescent; D000328:Adult; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D004804:Eosinophils; D005148:Facial Dermatoses / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D010787:Photosensitivity Disorders / Q000150:complications; D012130:Respiratory Hypersensitivity / Q000150:complications
D000974:Antibodies, Antinuclear; D007073:Immunoglobulin E