title: Porphyrin studies in TCDD-exposed workers.
abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to inhibit uroporphyrinogen decarboxylase activity resulting in chronic hepatic porphyria. From a cross-sectional study of 170 workers in chemical industry 68 showed elevated coproporphyrin levels, interpreted as secondary coproporphyrinuria. Three persons suffered from chronic hepatic porphyria in subclinical stages. None of the workers showed an overt porphyria cutanea tarda. A low-grade zinc protoporphyrinemia was observed in three persons. Forty-three of the 170 workers were evaluable for investigating the effect of TCDD on porphyrin levels. No significant correlation was found between TCDD concentration in adipose tissue and the level of uroporphyrin and coproporphyrin. The influence of a chloracne history is described.
authors.affiliation: Institut für Arbeits- und Sozialmedizin, Universität Mainz, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Konietzko
authors.forename: G
authors.initials: G
authors.lastname: Reill-Konietzko
authors.forename: A
authors.initials: A
authors.lastname: Muttray
authors.forename: H J
authors.initials: HJ
authors.lastname: Zimmermann-Hölz
authors.forename: M
authors.initials: M
authors.lastname: Doss
authors.forename: H
authors.initials: H
authors.lastname: Beck
authors.forename: L
authors.initials: L
authors.lastname: Edler
authors.forename: A
authors.initials: A
authors.lastname: Kopp-Schneider
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D002617:Chemical Industry; D005148:Facial Dermatoses / Q000453:epidemiology; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000453:epidemiology; D016273:Occupational Exposure; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis / Q000494:pharmacology*; D017094:Porphyrias, Hepatic / Q000453:epidemiology; D011166:Porphyrins / Q000378:metabolism*; D011524:Protoporphyrins / Q000097:blood
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D011166:Porphyrins; D011524:Protoporphyrins