title: Responses of inferior colliculus neurons in C57BL/6J mice with and without sensorineural hearing loss: effects of changing the azimuthal location of a continuous noise masker on responses to contralateral tones.
abstract: Extracellular recordings were obtained from inferior colliculus neurons of young adult (2-month-old) C57 mice with normal hearing and middle-aged (6-month-old) C57 mice with sensorineural hearing loss as they responded to best frequency (BF) tones (signal) in the presence of a continuous background noise (masker). Rate/level functions were obtained for the signal alone, noise bursts alone, and the signal in continuous noise as a function of masker location. For both groups of mice, thresholds for BF tones were significantly elevated in the presence of noise at all three noise locations. Separating the signal and masker sources significantly improved masked tone thresholds of 2-month-old mice but not hearing-impaired mice. The decreased ability of middle-aged mice to benefit from separation of the signal and masker sources may reflect alterations in binaural processing as a result of sensorineural hearing loss.
authors.affiliation: Department of Psychology, Northern Illinois University, DeKalb 60115.
authors.forename: S L
authors.initials: SL
authors.lastname: McFadden
authors.forename: J F
authors.initials: JF
authors.lastname: Willott
mesh_terms: D000161:Acoustic Stimulation; D000375:Aging / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D001299:Audiometry; D001309:Auditory Threshold / Q000502:physiology; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006319:Hearing Loss, Sensorineural / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D007245:Inferior Colliculi / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D011304:Presbycusis / Q000503:physiopathology; D013017:Sound Localization