title: Interpleural analgesia for postoperative pain relief in renal surgery patients.
abstract: The feasibility of interpleural analgesia for postoperative pain relief after renal surgery using anterior intercostal incision was studied in 16 adult patients. 20 ml bupivacaine plain 5 mg/ml in ten patients, and the same dose of bupivacaine with epinephrine 5 micrograms/ml in six patients, was injected through epidural catheter into the pleural space of the operated side, maximally three times per 24 hours. As additional pain medication, oxycodone i.m. was given if needed. In ten control patients, oxycodone was the only pain medication. Postoperative pain relief in patients who received interpleural bupivacaine plain was excellent in four, moderate in four and poor in two cases. For supplemental pain relief the patients were given 2.1 +/- 1.1 (SEM) injections of oxycodone during the three days. Control patients received, respectively. 11.6 +/- 0.7 injections of oxycodone, and they considered the pain relief excellent in six and moderate in four cases. Median duration of interpleural analgesia was in bupivacaine plain cases 6 h (range 2-14 h) and in bupivacaine with epinephrine 7 h (range 4-15 h). The mean peak serum concentration of bupivacaine plain was 1868 +/- 168 ng/ml, and that of bupivacaine with epinephrine 1312 +/- 273 ng/ml. No complications were seen. The results suggest that interpleural analgesia obtained by 20 ml bupivacaine 5 mg/ml three times a day gives most patients good pain relief.
authors.affiliation: Department of Anaesthesiology, Tampere University Hospital, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Kaukinen
authors.forename: L
authors.initials: L
authors.lastname: Kaukinen
authors.forename: J
authors.initials: J
authors.lastname: Kataja
authors.forename: S
authors.initials: S
authors.lastname: Kärkkäinen
authors.forename: A
authors.initials: A
authors.lastname: Heikkinen
mesh_terms: D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007669:Kidney Calculi / Q000601:surgery*; D052177:Kidney Diseases, Cystic / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010098:Oxycodone / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010994:Pleura / Q000187:drug effects*
chemical_list: D010098:Oxycodone; D002045:Bupivacaine