title: Captopril and its probable contaminants: NMR and MS features of analytical value.
abstract: The 400 MHz 1H NMR spectrum of captopril in a variety of solvents is analysed and compared with those of epicaptopril and its disulphide analogue. A method for detecting isomeric and oxidative impurities by examination of a 1H NMR spectrum of captopril in DMSO-d6 is proposed. 13C NMR and MS data enable differentiation of captopril from its disulphide analogue but not from its diastereoisomer epicaptopril.
authors.affiliation: School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
authors.forename: A F
authors.initials: AF
authors.lastname: Casy
authors.forename: G H
authors.initials: GH
authors.lastname: Dewar
mesh_terms: D002216:Captopril / Q000032:analysis*; D004220:Disulfides / Q000032:analysis; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013237:Stereoisomerism
chemical_list: D004220:Disulfides; D002216:Captopril