title: [Congenital deficiency of protein C with late clinical manifestation].
abstract: The congenital deficit of protein C has a great diversity of clinical manifestations regarding age. In this paper, we describe the case of a man whose initial symptomatology appeared at the age of 68. Protein C is a vitamin-K dependent plasmatic glycoprotein which has anticoagulant activity through the inactivation of factors Va and VIIIa. The hereditary deficit of protein C is usually presented in a dominant autosomic mode with partial penetration and its prevalence is estimated in each of 200-300 healthy blood donors.
authors.affiliation: Centro de Salud Virgen de Belén, Pilas.
authors.forename: M
authors.initials: M
authors.lastname: Ortega Calvo
authors.forename: J L
authors.initials: JL
authors.lastname: Méndez Mora
authors.forename: V
authors.initials: V
authors.lastname: Macías Pérez
authors.forename: F
authors.initials: F
authors.lastname: Mellado Fuentes
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000175:diagnosis*; D020151:Protein C Deficiency; D013997:Time Factors
vernacular_title: Déficit congénito de proteína C con expresión clínica tardía.