title: Serum hyaluronic acid for the assessment of graft viability in porcine liver transplantation.
abstract: For the assessment of graft viability, serum hyaluronic acid (HA) levels during porcine orthotopic liver transplantation were measured in two groups: group 1 (viable: n = 5) in which allografts were transplanted following a minimal cold (4 degrees C) preservation, and group 2 (nonviable: n = 4) in which allografts were transplanted after cold static storage (4 degrees C) for 24 h in University of Wisconsin solution. The changes in the HA levels reached a significant difference between the two groups at 30 min after reperfusion (P < 0.02). In group 1, all animals survived for over 4 days, while all animals in group 2 died within 24 h. The serum HA also demonstrated a significant correlation with prothrombin time, beta-glucuronidase, and aspartate aminotransferase at 120 min after reperfusion. These results suggest that the measurement of serum HA is a potentially effective index for evaluating hepatic allograft viability.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Itasaka
authors.forename: K
authors.initials: K
authors.lastname: Kishikawa
authors.forename: T
authors.initials: T
authors.lastname: Suehiro
authors.forename: K
authors.initials: K
authors.lastname: Yanaga
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: H
authors.initials: H
authors.lastname: Higashi
authors.forename: S
authors.initials: S
authors.lastname: Kakizoe
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Wakiyama
authors.forename: K
authors.initials: K
authors.lastname: Sugimachi
mesh_terms: D000818:Animals; D001706:Biopsy; D003080:Cold Temperature; D005260:Female; D006085:Graft Survival; D006820:Hyaluronic Acid / Q000097:blood*; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D016031:Liver Transplantation; D009926:Organ Preservation; D013552:Swine; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D006820:Hyaluronic Acid