[The forms of variability in a cell population as well as in an organism population. The biology of the development of the cardiac myocytes].
Variability of cells is analyzed using data obtained in studies on polyploidy in the heart muscle and on ontogenetic changes in the number of myocytes. In normal myocardium, variation in the number and ploidy of muscle cells is observed. The types of genomic variation are similar to those found in populations of organisms, i. e., to hereditary and modifying variation. In studies on modifications of the myocyte genome, heart growth reserves were revealed, which manifest themselves in pathological states associated with myocardial hypertrophy. These reserves depend on the level of myocardial polyploidy that is determined during early postnatal development.
Brodskiĭ
V Ia
VIa
D000818:Animals; D006332:Cardiomegaly / Q000235:genetics / Q000473:pathology; D003582:Cytogenetics; D014644:Genetic Variation; D016678:Genome; D006321:Heart / Q000254:growth & development*; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D011003:Ploidies
Formy izmenchivosti v kletochnoĭ populiatsii takie zhe, kak v populiatsii organizmov. Biologiia razvitiia serdechnykh miotsitov.