[Radioprotective effects of basic copper carboxylate complexes].
The radioprotective activity of eight selected copper (II) carboxylates--Cu (RCOO)2.nL (R = alkyl, aryl, 2-furyl and 2-thienyl; L usually represents water)--was assayed in a model of lethally gamma-irradiated (9 Gy, 0.97 Gy/min) mice. The compounds tested were applied (as solutions in saline) s.c. in three single doses of 20 mumol/kg 48.24 and 6 h before irradiation. The highest radioprotective effects were measured by survival of mice achieved after premedication of animals with copper (II) 2-thenoate monohydrate (77%), copper (II) acetylsalicylate (64%), copper (II) 2-methoxybenzoate monohydrate (62%) and copper (II) acetate monohydrate (54%). On the other hand, survival of vehicle-pretreated mice was only 10%. The observed biological properties of complexes are discussed in relation to their structures.
Gombosová
I
I
Katedra farmakológie a toxikológie a katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Valentová
J
J
Sokolík
J
J
Zemlicka
M
M
Svec
P
P
Laginová
V
V
D000818:Animals; D003300:Copper / Q000008:administration & dosage; D005720:Gamma Rays; D006168:Guinea Pigs; D051379:Mice; D008813:Mice, Inbred ICR; D009942:Organometallic Compounds / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage
D009942:Organometallic Compounds; D011837:Radiation-Protective Agents; D003300:Copper
Radioprotektivní úcinek nĕkterých základních karboxylatomĕdnatých komplexů.