Experimental transmission of hantavirus infection in laboratory rats.
This study found a competent transmission of hantavirus between cagemates using congenitally T cell-deficient Rowett nude rats (rnu/rnu). Intraperitoneally infected immunologically normal rats (rnu/+) did not transmit the hantavirus to their normal cagemates (rnu/+) but did to Rowett nude rats (rnu/rnu). Thus, nude rats were shown to be highly susceptible to the hantavirus infection. Also, infected nude rats (rnu/rnu) discharged the infectious viruses, to cause a prevalence of infection among normal cagemates (rnu/+). The infection system demonstrated here using Rowett rats (rnu/rnu) may provide a useful model to study the mechanism of the hantavirus infection.
Dohmae
K
K
Research Institute for Microbial Diseases, Osaka University, Japan.
Okabe
M
M
Nishimune
Y
Y
D000818:Animals; D000830:Animals, Laboratory; D000914:Antibodies, Viral / Q000097:blood; D018562:Disease Transmission, Infectious; D005260:Female; D005838:Genotype; D006476:Orthohantavirus / Q000254:growth & development / Q000276:immunology; D018778:Hantavirus Infections / Q000276:immunology / Q000635:transmission* / Q000662:veterinary / Q000821:virology; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011923:Rats, Nude / Q000821:virology*; D012376:Rodent Diseases / Q000276:immunology / Q000635:transmission* / Q000821:virology; D017201:Virus Shedding
D000914:Antibodies, Viral