[Recent proposals for early stage clinical trials of cancer].
Statistical designs for early stage cancer clinical trials, which include continual reassessment method for phase I and I-II studies, early stopping of phase II studies, randomized phase II and multi-stage phase II studies, are shortly reviewed. These recent proposals should be examined further as regards to their statistical characteristics as well as their ethical implication.
Ohashi
Y
Y
Dept. of Biostatistics and Epidemiology, School of Health Sciences and Nursing, University of Tokyo.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents