title: Pulmonary oedema and hypotension induced by hydrochlorothiazide.
abstract: We present the case of a patient with acute onset of dyspnoea after a long-distance flight. Pulmonary embolism was suspected, but could be excluded by perfusion scintigraphy. The electrocardiogram and chest X-ray were compatible with acute myocardial infarction and pulmonary oedema, but the slightness of the elevation of pulmonary capillary wedge pressure allowed cardiogenic pulmonary oedema to be excluded. The clinical picture was then interpreted as pneumonia with sepsis and hypotension. The rapid and full clinical recovery within 48 h, together with the close temporal relationship of ingestion of hydrochlorothiazide and the onset of symptoms, allowed the diagnosis of drug-induced pulmonary oedema and anaphylactoid hypotension.
authors.affiliation: Division of Pneumology, University Hospital of Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Leser
authors.forename: C T
authors.initials: CT
authors.lastname: Bolliger
authors.forename: J
authors.initials: J
authors.lastname: Winnewisser
authors.forename: F
authors.initials: F
authors.lastname: Burkart
authors.forename: A P
authors.initials: AP
authors.lastname: Perruchoud
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D007022:Hypotension / Q000139:chemically induced*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D011014:Pneumonia / Q000175:diagnosis; D011654:Pulmonary Edema / Q000139:chemically induced*
chemical_list: D006852:Hydrochlorothiazide