[Immunogenetics of systemic lupus: adequacy between HLA molecules class II and the germinal genes of antigen receptor of T-lymphocytes favours the production of various antibodies].
The study of 30 patients with systemic lupus and of 153 relatives failed to show any differences in HLA and TCR beta haplotype frequencies between patients and relatives. A significant interaction between TCR V beta and HLA-DR/DQ genes in the response to the peptide U1-RNP A 35-58 was demonstrated.
Youinou
P
P
Laboratoire d'immunologie, CHU Morvan, Brest.
Guillevin
L
L
Semana
G
G
Jouquan
J
J
Muller
S
S
Piette
J C
JC
D000917:Antibody Formation; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology
D006681:HLA-D Antigens; D011948:Receptors, Antigen, T-Cell
Immunogénétique du lupus systémique: l'adéquation entre molécules HLA de classe II et gènes germinaux du récepteur d'antigènes des lymphocytes T favorise la production de certains anticorps.