Congo red prolongs the incubation period in scrapie-infected hamsters.
In scrapie-infected cells, Congo red inhibits both the replication of the infectious agent and accumulation of the protease-resistant form of PrP (PrP-res). In this report, we show that Congo red prolongs the incubation periods of hamsters experimentally infected with two different strains of scrapie.
Ingrosso
L
L
Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
Ladogana
A
A
Pocchiari
M
M
D000818:Animals; D003224:Congo Red / Q000494:pharmacology*; D006224:Cricetinae; D008647:Mesocricetus; D018620:PrPSc Proteins / Q000187:drug effects*; D012608:Scrapie / Q000821:virology*; D014779:Virus Replication / Q000187:drug effects*
D018620:PrPSc Proteins; D003224:Congo Red