Circadian cancer pharmacodynamics.
After a large recognition of experiments and concepts developed in the centuries on the pharmacological treatment of human diseases, the article concisely provides the state of the art on chronotherapy of cancer. The techniques and results are illustrated. The perspectives of optimizing cancer therapy via optimal circadian schemes of pharmacological agents are clearly suggested.
Hrushesky
W J
WJ
Department of Veterans Affairs, Medical Center, Albany, New York.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D002455:Cell Division; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology; D051381:Rats
D000970:Antineoplastic Agents