title: Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers.
abstract: We studied the pharmacokinetics of the enantiomers of mefloquine in whole blood in healthy Thai volunteers after administration of a single oral dose of 750 mg of the racemic mixture. Mefloquine pharmacokinetics were stereoselective. The peak concentrations and areas under the curve of the (-) enantiomer were significantly higher than those of its antipode (0.79 versus 0.46 microgram.ml-1 and 402 versus 94 micrograms.h.ml-1). The half-lives of (-)MQ were significantly longer than those of (+)MQ (531 versus 206 h). No stereoselectivity was observed for tmax values.
authors.affiliation: Hôpital Pitié Salpêtrière, Service Pharmacie-Pharmacocinétique, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: F
authors.initials: F
authors.lastname: Gimenez
authors.forename: K N
authors.initials: KN
authors.lastname: Bangchang
authors.forename: J
authors.initials: J
authors.lastname: Karbwang
authors.forename: I W
authors.initials: IW
authors.lastname: Wainer
authors.forename: R
authors.initials: R
authors.lastname: Farinotti
mesh_terms: D000328:Adult; D044466:Asian People; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015767:Mefloquine / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D013237:Stereoisomerism
chemical_list: D015767:Mefloquine