Drug transfer across the placenta. Considerations in treatment and research.
Using the pregnant woman as a means to medicate her fetus represents a new and exciting therapeutic approach in clinical pharmacology. In years to come, we will see an increase in the use of the currently accepted fetal therapies and an increase in the number of therapies available to the caregiver or clinician aimed at assisting the unborn child. The pharmacologist, through in vitro research that aids our understanding of the role of the placenta in fetal drug therapy, can contribute to the growth of this new field within the realm of obstetric medicine.
Simone
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C
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Ontario, Canada.
Derewlany
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LO
Koren
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D000818:Animals; D001711:Biotransformation; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010599:Pharmacokinetics; D010920:Placenta / Q000033:anatomy & histology / Q000378:metabolism*; D011247:Pregnancy; D012106:Research