Predictive value of neonatal electroencephalograms before and during extracorporeal membrane oxygenation.
We studied the prognostic significance of electroencephalograms recorded serially at 2- to 4-day intervals during the acute neonatal course of 119 near-term infants with severe respiratory failure treated by venoarterial extracorporeal membrane oxygenation (ECMO). A poor prognosis was defined as early death (n = 27), an abnormally low developmental assessment score (n = 14), or cerebral palsy (n = 14) at 12 to 45 months of age. The only electroencephalographic abnormalities that were significantly related to a poor prognosis were burst suppression (B-S) and electrographic seizure (ES). The 30 infants with two or more recordings of B-S or ES, when compared with the 58 neonates without such electroencephalographic abnormalities, had an odds ratio for a poor prognosis of 6.6 (95% confidence limits, 2.2 to 20.2). The 31 infants with a single ES or B-S recording did not have a significantly increased risk for a poor prognosis. Cardiopulmonary resuscitation immediately before ECMO (n = 8) and the lowest systolic blood pressure before or during ECMO were significantly related to the occurrence of ES or B-S recordings. There was no significant predilection of ES for either cerebral hemisphere. We conclude that in near-term neonates with respiratory failure, serial electroencephalographic recordings are of predictive value, and may facilitate clinical care including the decision to initiate or to continue ECMO.
Graziani
L J
LJ
Department of Pediatrics, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania.
Streletz
L J
LJ
Baumgart
S
S
Cullen
J
J
McKee
L M
LM
D000208:Acute Disease; D016887:Cardiopulmonary Resuscitation; D016001:Confidence Intervals; D004569:Electroencephalography; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007231:Infant, Newborn; D009017:Morbidity; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012044:Regression Analysis; D016897:Respiratory Burst / Q000502:physiology; D012131:Respiratory Insufficiency / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D012307:Risk Factors; D013036:Spasms, Infantile / Q000209:etiology / Q000503:physiopathology; D015996:Survival Rate; D013997:Time Factors