title: Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.
abstract: Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Numata
authors.forename: E
authors.initials: E
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Minoura
authors.forename: H
authors.initials: H
authors.lastname: Eto
authors.forename: T
authors.initials: T
authors.lastname: Shingu
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D010879:Piperazines; C091120:leptosin I