Nodular transformation of splenic red pulp due to carcinomatous infiltration. A diagnostic pitfall.
Autopsy of three women dying of disseminated carcinoma of stomach, colon, and breast, respectively, revealed a grossly unremarkable spleen. Microscopic examination demonstrated a nodular transformation of the red pulp, simulating a follicular lymphoma. Immunostaining revealed dissociated carcinomatous cells between the nodules, and this was thought to be the cause of the nodular transformation.
Fakan
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Sikl's Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic.
Michal
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D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000473:pathology / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000473:pathology; D013160:Splenic Neoplasms / Q000473:pathology / Q000556:secondary*; D013274:Stomach Neoplasms / Q000473:pathology