title: Evaluation of competing tests for the diagnosis of pulmonary embolism and deep vein thrombosis, Part I.
abstract: Tests for pulmonary embolism (PE) and its most frequent source, deep vein thrombosis (DVT), include angiography, ventilation-perfusion nuclear medicine scans, venous sonography with Doppler, and contrast and radionuclide leg venography. Although selective angiography is the definitive procedure for the diagnosis of PE, the associated risk of death, although small, as well as the morbidity associated with injection of contrast agents, are high enough that alternative, less accurate, but safer diagnostic procedures are performed in an attempt to avoid the higher-risk procedure. Effective cost (EC) of each test represents the dollars spent per unit of diagnostic information and is defined as the ratio of the expected direct cost (EDC) of the test to its diagnostic performance (DU). EDC includes the base cost or charge of the test and the estimated cost of the morbidity and mortality that can be incurred in performing the test, while DU is determined from the test sensitivity and specificity. With the lowest EC as the selection criterion for the best test and representative costs, sensitivity, specificity, and morbidity and mortality rates, five different tests for PE or DVT were compared. Doppler sonography yielded the most diagnostic information per dollar spent, as its EC was the lowest, primarily because its base cost was low compared to that of the other tests. Radionuclide leg venography had the second lowest EC. Selection among the remaining three tests depended on the prevalence of PE and morbidity and mortality costs.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Radiology, New York Hospital-Cornell University Medical College, New York 10021.
authors.forename: C I
authors.initials: CI
authors.lastname: Henschke
authors.forename: D F
authors.initials: DF
authors.lastname: Yankelevitz
authors.forename: I
authors.initials: I
authors.lastname: Mateescu
authors.forename: J P
authors.initials: JP
authors.lastname: Whalen
mesh_terms: D000792:Angiography; D003362:Cost-Benefit Analysis; D005069:Evaluation Studies as Topic; D006801:Humans; D010690:Phlebography; D011336:Probability; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography