title: Elevation of serum group II phospholipase A2 levels in patients with advanced cancer.
abstract: To investigate the role of group II phospholipase A2 (M-PLA2) in cancer, we examined M-PLA2 serum levels in 170 pre-operative patients with various cancers and found elevated levels in 49% of them. M-PLA2 serum levels were significantly higher in patients with tumor stages T2-4, N1, M1 and stages II to IV than in T1, N0, M0 and stage I tumors, respectively. In all nine post-operative patients tested, M-PLA2 decreased 14 days after tumor resection and reduced to normal levels in 4 patients. Six of 16 carcinoma cell lines (37.5%) spontaneously secreted M-PLA2 into the culture supernatant despite the absence of IL-6 and IL-1 in 5 of the 6 lines. These results demonstrate that M-PLA2 produced by cancer cells may contribute, at least in part, to the elevation of serum M-PLA2 levels observed in cancer patients.
authors.affiliation: Department of Surgery II, Kumamoto University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Arakawa
authors.forename: J
authors.initials: J
authors.lastname: Yamashita
mesh_terms: D001650:Bile Duct Neoplasms / Q000201:enzymology / Q000601:surgery; D001943:Breast Neoplasms / Q000201:enzymology / Q000601:surgery; D003110:Colonic Neoplasms / Q000201:enzymology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000601:surgery; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008113:Liver Neoplasms / Q000201:enzymology / Q000601:surgery; D008175:Lung Neoplasms / Q000201:enzymology / Q000601:surgery; D009367:Neoplasm Staging; D009369:Neoplasms / Q000201:enzymology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000601:surgery; D010741:Phospholipases A / Q000097:blood* / Q000378:metabolism; D054467:Phospholipases A2; D013274:Stomach Neoplasms / Q000201:enzymology / Q000601:surgery; D014407:Tumor Cells, Cultured
chemical_list: D015850:Interleukin-6; D010741:Phospholipases A; D054467:Phospholipases A2