HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus.
Antibodies to the ribosomal P protein are specific for SLE but their prevalence varies in different ethnic groups. In a group of Chinese SLE patients from Malaysia who have a high prevalence of this antibody, we have found an increased frequency of an uncharacterized HLA-DRB gene allele, DR16X, in patients who are positive for anti-P antibodies compared to antibody negative patients (31.3% vs 3.2%, P < 0.01, Pcorr not significant, relative risk = 13.6). DR16X has only been found in south east Asian populations and may be a genetic factor which influences the high prevalence of anti-P antibodies in Chinese.
Teh
L S
LS
Rheumatology Research Centre, University Hospital of Wales, Heath Park, Cardiff.
Doherty
D G
DG
Williams
B D
BD
D000483:Alleles; D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D044466:Asian People / Q000235:genetics; D002681:China / Q000208:ethnology; D003181:Complement C4 / Q000235:genetics; D015935:Complement C4b; D004797:Enzyme-Linked Immunosorbent Assay; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D008296:Malaysia / Q000453:epidemiology; D010446:Peptide Fragments; D015995:Prevalence; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000276:immunology*
D000906:Antibodies; D003181:Complement C4; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; C064601:L12E protein, Trypanosoma cruzi; D010446:Peptide Fragments; D015800:Protozoan Proteins; D012269:Ribosomal Proteins; C033860:complement C4c; D015935:Complement C4b