Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal.
The effect of a mixture of valepotriates on the elevated plus-maze performance of diazepam withdrawn rats was evaluated. The rats were chronically (28 days) treated with diazepam (doses increased up to 5.0 mg/kg) and then treated with control solution for 3 days to induce a withdrawal syndrome. Chronically vehicle-treated rats were used as control. The abstinent animals treated with vehicle showed a significant decrease in the percentage of time spent in the open arms when compared with the control animals. Diazepam and valerian 12.0 mg/kg reversed this anxiogenic effect. Valerian 6.0 mg/kg did not show any difference in relation to the others group.
Andreatini
R
R
Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo, Brazil.
Leite
J R
JR
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D039823:Iridoids; D008297:Male; D010805:Physical Conditioning, Animal; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000517:prevention & control; D014632:Valerian
D039823:Iridoids; D010936:Plant Extracts; D011619:Psychotropic Drugs; D011714:Pyrans; C024750:didrovaltrate; C030127:valtrate; D003975:Diazepam; C090810:acevaltrate