Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats.
1. Lipoperoxidation (LPx) and glutathione peroxidase (GPx) activity were measured in kidney, liver, heart, lung, brain and testis from control and puromycin aminonucleoside (PAN) injected rats on days 1-6, 8, 10, 16 and 22 after vehicle or PAN injection. 2. PAN-injected rats developed proteinuria on day 3. 3. In PAN-injected rats: (a) LPx increased in kidney, liver, lung, brain and testis before day 3 and in heart on day 3; (b) GPx activity increased in kidney, liver, heart, lung and testis and diminished in brain on day 3 or after.
Pedraza-Chaverri
J
J
Department of Nephrology and Mineral Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México D.F., Mexico.
Arévalo
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AE
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D007019:Hypoproteinemia / Q000139:chemically induced; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D011507:Proteinuria / Q000139:chemically induced; D011692:Puromycin Aminonucleoside / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects / Q000201:enzymology; D014018:Tissue Distribution / Q000187:drug effects
D011692:Puromycin Aminonucleoside; D005979:Glutathione Peroxidase