Successful treatment of sinusitis caused by Cunninghamella bertholletiae.
Seventeen cases of infections due to Cunninghamella species have been reported worldwide in humans, and there have been only three survivors. We report a case of paranasal sinusitis due to Cunninghamella bertholletiae in an elderly patient who had diabetes mellitus and myelodysplasia. After receiving 7 weeks of therapy with deoxycholate amphotericin B (44 mg/kg or a total of 3 g) and rifampin, the patient was cured and did not have to undergo radical surgery.
Ng
T T
TT
Department of Microbiology, Hope Hospital, Manchester, United Kingdom.
Campbell
C K
CK
Rothera
M
M
Houghton
J B
JB
Hughes
D
D
Denning
D W
DW
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004359:Drug Therapy, Combination; D015521:Ethmoid Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D009090:Mucorales / Q000302:isolation & purification; D009091:Mucormycosis / Q000150:complications / Q000188:drug therapy*; D009190:Myelodysplastic Syndromes / Q000150:complications; D010256:Paranasal Sinuses / Q000382:microbiology; D012293:Rifampin / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D000666:Amphotericin B; D012293:Rifampin