title: B-cell acute lymphoblastic leukemia with L1 morphology and coexistence of t(1;19) and t(14;18) chromosome translocations.
abstract: We report a case of adult de novo acute lymphoblastic leukemia (ALL) with unique cytogenetic abnormalities and discrepant morphologic and immunologic features. Morphology was L1 by the French-American-British classification, but flow cytometry was consistent with a mature B-cell phenotype. Cytogenetic analysis showed numerous chromosome abnormalities nonspecific for lymphoid neoplasm except for t(1;19) and t(14;18). The former is characteristic of pre-B-ALL and the latter is characteristic of follicular lymphoma. This is the first report of these two translocations occurring concurrently in ALL.
authors.affiliation: Strong Memorial Hospital, Rochester, New York.
authors.forename: P A
authors.initials: PA
authors.lastname: Kouides
authors.forename: P D
authors.initials: PD
authors.lastname: Phatak
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Bennett
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D008875:Middle Aged; D014178:Translocation, Genetic