title: Diaspirin crosslinked hemoglobin (DCLHb) polymerization.
abstract: By employing proprietary polymerization agents possessing specific binding groups and by completing diaspirin crosslinked hemoglobin (DCLHb) polymerization under specific conditions, we have selectively achieved the following objectives: (1) the P50 was adjusted to the physiologic range or left- or right-shifted; (2) the surface of DCLHb was modified ("decorated"); (3) DCLHb was polymerized but not decorated; (4) DCLHb was polymerized and decorated; or (5) DCLHb was site-specifically modified and polymerized.
authors.affiliation: Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, IL 60073.
authors.forename: T T
authors.initials: TT
authors.lastname: Hai
authors.forename: D
authors.initials: D
authors.lastname: Nelson
authors.forename: D
authors.initials: D
authors.lastname: Pereira
authors.forename: A
authors.initials: A
authors.lastname: Srnak
mesh_terms: D000599:Amino Acids, Diamino; D001241:Aspirin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D001665:Binding Sites; D001802:Blood Substitutes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D000087522:Cyanobacteria Toxins; D006454:Hemoglobins / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D010100:Oxygen / Q000378:metabolism; D011092:Polyethylene Glycols; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000599:Amino Acids, Diamino; D001802:Blood Substitutes; D000087522:Cyanobacteria Toxins; D006454:Hemoglobins; D007202:Indicators and Reagents; D011108:Polymers; C001824:beta-N-methylamino-L-alanine; D011092:Polyethylene Glycols; C083478:diaspirin-cross-linked hemoglobin; D001241:Aspirin; D010100:Oxygen