Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloading.
Using antiorthostatic suspension, we characterized hematopoietic changes that may be responsible for the detrimental effect of skeletal unloading on macrophage development. Skeletally unloaded mice had suppressed macrophage development in unloaded and loaded bones, which indicated a systemic effect. Bone marrow cells from unloaded mice secreted less macrophage colony-stimulating factor and interleukin-6 than control mice. Additionally, T-lymphocyte proliferation was reduced after skeletal unloading. We show that polyethylene glycol-interleukin-2 therapy reversed the effects of skeletal unloading on macrophage development and cell proliferation.
Armstrong
J W
JW
Division of Biology, Kansas State University, Manhattan 66506.
Balch
S
S
Chapes
S K
SK
D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D001854:Bone Marrow Cells; D002452:Cell Count; D016207:Cytokines / Q000378:metabolism; D007103:Immobilization; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D011994:Recombinant Proteins / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology
D016207:Cytokines; D007376:Interleukin-2; D011994:Recombinant Proteins