Effect of phenacetin pretreatment on renal pelvic carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice of both sexes.
Influences of phenacetin (PH) pretreatment on renal pelvic carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were examined in NON/Shi mice of both sexes. Histopathological examination revealed that PH pretreatment enhanced not only the induction of urinary tract carcinoma but also distant metastasis of renal pelvic carcinoma by BBN in male mice. The high incidence of urinary tract carcinoma by PH pretreatment might be due to hydronephrosis and epithelial proliferative lesions enhanced by PH, since a single treatment of PH induced hydronephrosis in all mice and simple hyperplasia in 70-80% of mice used.
Murai
T
T
First Department of Pathology, Osaka City University Medical School, Japan.
Mori
S
S
Hosono
M
M
Takeuchi
Y
Y
Oohara
T
T
Makino
S
S
Takeda
R
R
Fukushima
S
S
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D005260:Female; D006869:Hydronephrosis / Q000139:chemically induced; D006965:Hyperplasia; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007682:Kidney Pelvis / Q000473:pathology; D008297:Male; D051379:Mice; D010615:Phenacetin / Q000633:toxicity*; D012737:Sex Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002085:Butylhydroxybutylnitrosamine; D010615:Phenacetin