title: Effect of ventilation on resuscitation in an animal model of cardiac arrest.
abstract: BACKGROUND
  The need for ventilation during the initial management of cardiac arrest is an important public health problem that is being debated. The present study was designed to determine whether ventilation affects return of spontaneous circulation from cardiac arrest in a swine model with an interval of untreated ventricular fibrillation of 6 minutes, as reported in witnessed out-of-hospital human cardiac arrest.
  
  
  RESULTS
  Twenty-four animals were randomly assigned to two groups: one that received ventilation during the first 10 minutes of chest compression and one that did not. Coronary perfusion pressure and minute ventilation were continuously recorded. Arterial and mixed venous blood gases were measured at intervals. Return of spontaneous circulation was defined prospectively as an aortic systolic blood pressure of > 80 mm Hg for > 5 minutes and was the primary outcome variable. All animals were anesthetized, paralyzed, and intubated. Ventricular fibrillation was induced and persisted for 6 minutes without chest compression, followed by mechanical chest compression for 10 minutes and then attempted defibrillation. Animals without return of spontaneous circulation were given epinephrine, ventilation, and chest compression for an additional 3 minutes. Defibrillation was again attempted, and animals were assessed for return of spontaneous circulation. There were no significant differences between the two groups in baseline prearrest mean cardiac index, coronary perfusion pressure, or arterial and mixed venous blood gases. However, after 9 minutes of chest compression, significant differences were noted between the ventilated and nonventilated groups. The nonventilated group had significantly (P < .05) lower mean arterial PO2 (38 +/- 17 mm Hg compared with 216 +/- 104 mm Hg) and higher PCO2 (62 +/- 16 mm Hg compared with 35 +/- 8 mm Hg), lower mixed venous PO2 (15 +/- 7 mm Hg compared with 60 +/- 7 mm Hg). Nine of 12 (75%) of the ventilated animals, and only 1 of 12 (8%) of the nonventilated animals had return of spontaneous circulation after cardiac arrest (P < .002).
  
  
  CONCLUSIONS
  In this animal model of cardiac arrest, ventilation was important for resuscitation. The importance of ventilation could be related to the prolonged duration of untreated ventricular fibrillation and the significantly greater hypoxia and hypercarbic acidosis found in the nonventilated animals.
authors.affiliation: Department of Surgery, (Division of Emergency Medicine), University of Florida College of Medicine, Gainesville 32610-0392.
authors.forename: A H
authors.initials: AH
authors.lastname: Idris
authors.forename: L B
authors.initials: LB
authors.lastname: Becker
authors.forename: R S
authors.initials: RS
authors.lastname: Fuerst
authors.forename: V
authors.initials: V
authors.lastname: Wenzel
authors.forename: W J
authors.initials: WJ
authors.lastname: Rush
authors.forename: R J
authors.initials: RJ
authors.lastname: Melker
authors.forename: D J
authors.initials: DJ
authors.lastname: Orban
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016887:Cardiopulmonary Resuscitation; D003326:Coronary Circulation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006323:Heart Arrest / Q000503:physiopathology*; D012121:Respiration, Artificial; D013552:Swine; D014693:Ventricular Fibrillation / Q000503:physiopathology
chemical_list: D004837:Epinephrine