title: Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9.
authors.affiliation: Department of Medicinal Chemistry, University of Washington, Seattle 98195.
authors.forename: A E
authors.initials: AE
authors.lastname: Rettie
authors.forename: L C
authors.initials: LC
authors.lastname: Wienkers
authors.forename: F J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: W F
authors.initials: WF
authors.lastname: Trager
authors.forename: K R
authors.initials: KR
authors.lastname: Korzekwa
mesh_terms: D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases; D065729:Cytochrome P-450 CYP2C9; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D011994:Recombinant Proteins / Q000378:metabolism; D013237:Stereoisomerism; D039181:Steroid 16-alpha-Hydroxylase; D014044:Tolbutamide / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014859:Warfarin / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D000096926:Benzenesulfonamides
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; D065729:Cytochrome P-450 CYP2C9; D003577:Cytochrome P-450 Enzyme System; D011994:Recombinant Proteins; D039181:Steroid 16-alpha-Hydroxylase; D014044:Tolbutamide; D014859:Warfarin; C031014:hydroxymethyltolbutamide; D000096926:Benzenesulfonamides; C087837:7-hydroxywarfarin; C450260:CYP2C9 protein, human; C008091:6-hydroxywarfarin