title: Enucleation combined with hepatic vascular exclusion is a safe and effective alternative to hepatic resection for liver cell adenoma.
abstract: Liver cell adenomas are benign, rare tumors that occur primarily in women with a history of oral contraceptive use. Surgical treatment is recommended to reduce the risk of sudden, unpredictable hemorrhage or malignant transformation, but mortality rates of 5 to 8 per cent are reported for major hepatic resections. This report summarizes an experience of eight patients with liver cell adenoma treated by enucleation or resection, alone or combined with hepatic vascular exclusion (HVE). The latter technique, originally described in the mid-1960s, markedly reduces operative blood loss associated with hepatic resection. All eight patients were women of child-bearing age, and seven reported previous oral contraceptive use. The majority of patients were asymptomatic at the time of presentation. Six patients (75%) had a single adenoma and the remaining two had multiple lesions. HVE was used successfully in four patients with no perioperative mortality and reduced by nearly 50 per cent the intraoperative blood loss compared to conventional hepatic resection (1635 mL versus 3875 mL, respectively). Six evaluable patients were followed for an average of 65 months, with no evidence of liver dysfunction or adenoma recurrence. Enucleation of liver cell adenoma appears to be a safe alternative to formal hepatic resection and provides excellent long-term results. HVE markedly reduces operative blood loss, has no adverse effect on metabolic function, decreases the potential health risk associated with transfusion, and should be used whenever possible.
authors.affiliation: Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0331.
authors.forename: F E
authors.initials: FE
authors.lastname: Eckhauser
authors.forename: J A
authors.initials: JA
authors.lastname: Knol
authors.forename: S E
authors.initials: SE
authors.lastname: Raper
authors.forename: N W
authors.initials: NW
authors.lastname: Thompson
mesh_terms: D018248:Adenoma, Liver Cell / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D016063:Blood Loss, Surgical; D003276:Contraceptives, Oral / Q000009:adverse effects; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000098:blood supply; D008113:Liver Neoplasms / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003276:Contraceptives, Oral