title: Ethnic differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers.
abstract: The differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers were studied in a randomized crossover design. The half-life of antipyrine was found to be 18.8 +/- 4.89 h in 16 Han and 15.0 +/- 3.02 h in 17 Tibetan (P < 0.05) and the clearance was 1.35 +/- 0.37 L.h-1 in Han and 1.71 +/- 0.44 L.h-1 in Tibetan (P < 0.05). The half-life of acetaminophen was 3.1 +/- 0.86 h in Han and 3.2 +/- 1.12 h in Tibetan (P > 0.05). The experimental results indicate that the disposition of antipyrine between Tibetan and Han healthy volunteers significantly differed, the clearance of antipyrine in Tibetan increased by 20%, but the disposition of acetaminophen between the two ethnic groups showed no difference.
authors.affiliation: Tangdu Hospital, 4th Military Medical University, Xi' an.
authors.forename: P
authors.initials: P
authors.lastname: He
authors.forename: G X
authors.initials: GX
authors.lastname: Liu
authors.forename: Z H
authors.initials: ZH
authors.lastname: Liu
authors.forename: F Y
authors.initials: FY
authors.lastname: Sun
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics*; D000293:Adolescent; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics*; D044466:Asian People; D018592:Cross-Over Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D013045:Species Specificity
chemical_list: D000082:Acetaminophen; D000983:Antipyrine