[Pharmacokinetics and plasma protein binding of sulfamethoxypyridazine in camels (Camelus dromedarius)].
The pharmacokinetics of sulfamethoxypyridazine (SMPD) were investigated in the camel after intravenous and oral administration. After intravenous injection, the plasma concentration of the drug followed the kinetics of a two-compartment model. The steady-state volume of distribution (Vss) of 0.47 l/kg suggested that sulfamethoxypyridazine was mostly distributed within the vascular compartment and the strongly vascularized tissues. The elimination from the body was rather slow, with a biological half-life [t1/2(beta)] and a total plasma clearance of about 9.5 h and 0.037 l/kg.h, respectively. Oral treatment showed that the maximum plasma concentration was reached 17 hours post drug administration and that the bioavailability ranged around 57%. Study of the plasma protein binding showed that the percentage of SMPD binding to plasma proteins varied from 47 to 72% and seemed to be concentration-dependent. The total binding capacity and the dissociation constant at equilibrium were 196 micrograms/ml and 335 micrograms/ml, respectively.
Abdennebi
E H
EH
Département de Pharmacologie, Toxicologie et Biochimie, Institut Agronomique et Vétérinaire Hassan II, Rabat, Maroc.
Bousfiha
A
A
Ben Goumi
M
M
Oukessou
M
M
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002162:Camelus / Q000378:metabolism*; D009018:Morocco; D011485:Protein Binding; D013421:Sulfamethoxypyridazine / Q000378:metabolism / Q000493:pharmacokinetics*
D001798:Blood Proteins; D013421:Sulfamethoxypyridazine
Etude de la pharmacocinétique et de la liaison aux protéines plasmatiques de la sulfaméthoxypyridazine chez le dromadaire (Camelus dromedarius).