The in vivo gracilis muscle model of skeletal muscle ischemia.
The bilateral canine gracilis muscle has been studied as a model of acute skeletal muscle ischemia. Early investigations demonstrated that preparation of the model did not alter the energy profile of the muscle. Changes in energy metabolism during ischemia and after reperfusion have been extensively investigated using this model. Further investigations are reviewed that have explored the mechanisms of injury during reperfusion, including oxygen free radical production, calcium influx, neutrophil infiltration, and complement activation. These experiments have furthered our understanding of the pathophysiologic changes that occur in skeletal muscle after ischemia and laid the groundwork for future experiments to reduce reperfusion injury and salvage ischemic skeletal muscle.
Lindsay
T F
TF
Toronto General Hospital, University of Toronto, Ontario, Canada.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D009132:Muscles / Q000378:metabolism / Q000503:physiopathology*; D015427:Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology*; D013696:Temperature; D013997:Time Factors
D000227:Adenine Nucleotides