Use of nasal cytology in the diagnosis of occult chronic sinusitis in asthmatic children.
BACKGROUND
Chronic sinusitis, in contrast to acute sinusitis, often presents with nonspecific symptoms that may be confused with other disease entities. Due to the cost of computerized tomography and the difficulty in interpreting sinus radiographs in certain children, a search for a simpler screening tool for chronic sinusitis in children was undertaken.


OBJECTIVE
This study was undertaken to provide a quantitative comparison between the methods of wax paper blow and Rhinoprobe scraping for nasal cytology in screening for chronic sinusitis while minimizing selection bias.


METHODS
Twenty serially selected patients (13 males and seven females) with a mean age of 11 years (range 6-16) were enrolled. Nasal cytology was obtained via two methods: scraping of the turbinate with a Rhinoprobe (Synbiotics Inc.,) and wax paper blow.


RESULTS
The results showed that > or = 5 neutrophils per high power field on Rhinoprobe cytology significantly correlated with radiographic sinusitis (P < .05 by Chi-square and P < .056 by Fisher's exact test). The sensitivity and specificity for > or = 5 neutrophils per high power field were 100% and 53%, respectively. Counts of other nasal cells, such as eosinophils, bacteria, and epithelial cells, did not yield significant correlations with radiographic sinusitis.


CONCLUSIONS
We feel that the Rhinoprobe, with criteria of > or = 5 neutrophils per high power field, may be useful as a screen for occult chronic sinusitis in childhood asthma. Confirmation of sinusitis via X-ray is still necessary if neutrophils are present on Rhinoprobe nasal cytology.
Jong
C N
CN
University of Kansas Medical Center, Department of Pediatric Allergy, Kansas City.
Olson
N Y
NY
Nadel
G L
GL
Phillips
P S
PS
Gill
F F
FF
Neiburger
J B
JB
D000293:Adolescent; D001249:Asthma / Q000150:complications / Q000175:diagnosis*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009297:Nasal Mucosa / Q000166:cytology*; D009504:Neutrophils / Q000166:cytology; D009666:Nose / Q000166:cytology; D012680:Sensitivity and Specificity; D012852:Sinusitis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed