[The evaluation of the efficacy of efferent therapy in patients with acute and chronic kidney failure by the spectrum of blood middle-molecule fractions].
Blood serum endotoxins were studied in patients with acute and chronic renal failure in order to correlate this spectrum with the treatment efficacy. Gel [correction of Liquid] chromatography tests of the serum samples were made in 106 patients on hemodialysis, hemodiafiltration and hemosorption. Hemodialysis was found to significantly reduce concentration of middle-mass molecular fraction (C, D, F with molecular mass from 300 to 2000 D). Hemodiafiltration produced the same effect, but more rapidly. A single procedure of hemosorption was able to improve the patients condition in the course of 2 postprocedure weeks. The authors attribute this effect to removal of the molecular fraction A which is highly toxic.
Kon'kova
T A
TA
Chudnovskaia
M V
MV
Golovanov
S A
SA
D058186:Acute Kidney Injury / Q000097:blood* / Q000628:therapy; D002850:Chromatography, Gel / Q000295:instrumentation / Q000379:methods; D017583:Hemodiafiltration; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008970:Molecular Weight; D010455:Peptides / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors; D014118:Toxins, Biological / Q000097:blood*
D010455:Peptides; D014118:Toxins, Biological; C026865:uremia middle molecule toxins
Otsenka éffektivnosti éfferentnoĭ terapii bol'nykh s ostroĭ i khronicheskoĭ pochechnoĭ nedostatochnost'iu po spektru srednemolekuliarnykh fraktsiĭ krovi.