[Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?].
TNF-alpha, ICAM1, VCAM1, ELAM, CD44 and DR expression were studied (indirect immunoperoxydase methods) on labial salivary gland sections in 5 patients with proven rheumatoid vasculitis (before and after treatment), 5 patients with RA and 5 normal controls. TNF-alpha and cell adhesion molecules were particularly expressed in vasculitic areas of patients with systemic vasculitis and only before the onset of the treatment.
Flipo
R M
RM
Service de rhumatologie, hôpital B, CHRU de Lille.
Cardon
T
T
Foulet
A
A
Hachulla
E
E
Duquesnoy
B
B
Delcambre
B
B
Janin
A
A
D015415:Biomarkers; D015815:Cell Adhesion Molecules / Q000032:analysis*; D006801:Humans; D011695:IgA Vasculitis / Q000473:pathology / Q000503:physiopathology*; D012470:Salivary Glands, Minor / Q000737:chemistry / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D014409:Tumor Necrosis Factor-alpha
L'expression du TNF alpha et des molécules d'adhésion constitue-t-elle un marqueur d'évolutivité de la vascularite rhumatoïde?