title: Ultrastructure of spontaneous glomerular lesions in syrian hamsters of APA strain.
abstract: Electron microscopic observations were carried out on the spontaneous glomerular lesions in male APA hamsters from 3 to 12 months of age. Until 6 months of age, focal expansion of mesangial region due to an increase of matrix material and mesangial cells was characteristic, and segmental thickening of capillary basement membrane and partial effacement of foot processes of podocytes were also sometimes observed. At 12 months of age, although all of these changes became more severe, the most prominent alteration was found in podocytes, which showed various degenerative changes. No deposition of amyloid fibrils was detected in any portion of the glomerulus.
authors.affiliation: Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamanouchi
authors.forename: A
authors.initials: A
authors.lastname: Yasoshima
authors.forename: J S
authors.initials: JS
authors.lastname: Han
authors.forename: S
authors.initials: S
authors.lastname: Itagaki
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight; D006224:Cricetinae; D005920:Glomerular Mesangium / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008647:Mesocricetus; D009929:Organ Size