Application of new coatings for vascular grafts based on polyacrylic systems with antiaggregating activity.
A study has been made of the behaviour of knitted and woven Dacron mesh used in the preparation of vascular grafts when coated with either a layer of poly(2-hydroxyethyl methacrylate) or co-polymers of 2-hydroxyethyl methacrylate with 5, 10 or 20 wt% of an acrylic derivative of salicylic acid, 2-methacryloyloxybenzoic acid. In vitro studies were carried out to quantify the loss of polymer under flow conditions, and ex vivo studies were done in dogs to quantify the deposition of 111In-oxine-labelled platelets. The treated materials showed a lesser deposition of platelet thrombi when compared with the control group.
San Román
J
J
Instituto de Ciencia y Tecnología de Polímeros, CSIC, Madrid, Spain.
Escudero
M C
MC
Gallardo
A
A
Santa Cruz
R
R
Jorge
E
E
de Haro
J
J
Alvarez
L
L
Millán
I
I
Buján
J
J
Bellón
J M
JM
D000818:Animals; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000187:drug effects; D001807:Blood Vessel Prosthesis; D002448:Cell Adhesion / Q000187:drug effects; D004285:Dogs; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011093:Polyethylene Terephthalates; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology
D001672:Biocompatible Materials; D008689:Methacrylates; D010975:Platelet Aggregation Inhibitors; D011093:Polyethylene Terephthalates; D011102:Polyhydroxyethyl Methacrylate; C005044:hydroxyethyl methacrylate