title: Treatment of orbital capillary haemangioma with interferon.
abstract: BACKGROUND
  Capillary haemangiomas are vascular tumours of childhood characterised by proliferative and involutional phases and affecting 1% to 2% of newborns. Recently, recombinant interferons have been used in the treatment of life and sight threatening complications of these tumours.
  
  
  METHODS
  The history, results of examination, investigations, management and outcome of two patients with sight-threatening orbital capillary haemangiomas treated with recombinant interferon alpha-2a and 2b respectively were reviewed.
  
  
  RESULTS
  Orbital and systemic lesions displayed good response to interferons. Side effects noted were transient pyrexia and elevated serum aminotransferase levels. Disturbed liver function test results occurred in one case and normalised with temporary cessation of therapy.
  
  
  CONCLUSIONS
  The interferons are a useful alternative treatment of orbital capillary haemangioma in selected cases.
authors.affiliation: Department of Ophthalmology, Royal Childrens Hospital, Brisbane, Queensland.
authors.forename: S
authors.initials: S
authors.lastname: Teske
authors.forename: S J
authors.initials: SJ
authors.lastname: Ohlrich
authors.forename: G
authors.initials: G
authors.lastname: Gole
authors.forename: P
authors.initials: P
authors.lastname: Spiro
authors.forename: M
authors.initials: M
authors.lastname: Miller
authors.forename: T J
authors.initials: TJ
authors.lastname: Sullivan
mesh_terms: D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy; D018324:Hemangioma, Capillary / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D011994:Recombinant Proteins; D013274:Stomach Neoplasms / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins