title: Appreciation of the significance of cytogenetic and FISH analysis of bone marrow in clinical oncology.
abstract: Due to some empiric reasons, bone marrow (BM) has never been emphasized and appreciated as a valuable alternative source for metaphases of tumor nature. In the present study, we report the cytogenetic and fluorescence in situ hybridization (FISH) studies of BM in 172 patients with various tumors. Our results indicate that cytogenetic and FISH analyses of BM provide a valuable biologic approach concerning the diagnosis of tumors, evaluation of metastasis, and assessment of secondary hematologic malignancies. Thus, we suggest strongly that these studies become a standard part of clinical pathologic investigations in dealing with clinical oncology.
authors.affiliation: Genetrix, Inc., Scottsdale, Arizona.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Morgan
authors.forename: J F
authors.initials: JF
authors.lastname: Stone
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations; D005260:Female; D006402:Hematologic Diseases / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology