title: Technetium-99m hexamethylpropyleneamineoxime labelled leucocyte scanning in the initial diagnosis of Crohn's disease.
abstract: The technetium hexamethylpropyleneamineoxime labelled white cell scan (WCS) is not widely used as a screening test for Crohn's disease primarily because, though sensitive, it is perceived as being insufficiently specific. A series of 42 patients screened for Crohn's disease by this method was analysed retrospectively. The sensitivity was 100% and specificity 91%. This performance was maintained in a subgroup of these patients with very low prevalence of disease. If appropriate criteria for interpretation are used the WCS is a specific as well as a sensitive screening test for Crohn's disease.
authors.affiliation: Department of Nuclear Medicine, Royal London Hospital, UK.
authors.forename: P N
authors.initials: PN
authors.lastname: Malcolm
authors.forename: C P
authors.initials: CP
authors.lastname: Bearcroft
authors.forename: P G
authors.initials: PG
authors.lastname: Pratt
authors.forename: D S
authors.initials: DS
authors.lastname: Rampton
authors.forename: N W
authors.initials: NW
authors.lastname: Garvie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime