title: Treatment of interstitial pregnancy with methotrexate: report of an unsuccessful case.
abstract: Until now, the traditional management of interstitial pregnancy has been surgical. Lately, we have advocated conservative treatment with methotrexate as an option for infertility patients. This is the first publication of a rupture with abundant intra-abdominal bleeding during systemic treatment with methotrexate of a patient with an interstitial pregnancy. Signs of therapy failure are discussed.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: R R
authors.initials: RR
authors.lastname: Voigt
authors.forename: F
authors.initials: F
authors.lastname: van der Veen
authors.forename: V H
authors.initials: VH
authors.lastname: Karsdorp
authors.forename: H V
authors.initials: HV
authors.lastname: Hogerzeil
authors.forename: B W
authors.initials: BW
authors.lastname: Ketting
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006470:Hemorrhage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D012422:Rupture, Spontaneous; D014463:Ultrasonography
chemical_list: D006063:Chorionic Gonadotropin; D008727:Methotrexate