title: [Survival and recurrence of endometrial adenocarcinoma].
abstract: 444 endometrial carcinomas were retrospectively reviewed. Disease-free survival (DFS) was 83.6% at five years and 80.5% at ten years. 349 T1 cancers were treated by TAH-BSO and post-operative irradiation; 22.6% of them were over-staged. DFS ranged from 100% to 91% in 270 low-risk T1 patients, dropping to 84% in intermediate risk patients and to 44% in high-risk patients. DFS was 93% and 66% in the patients overstaged as pT2 and pT3, respectively; it was 82% for ovarian spread and 45% for pelvic peritoneum/parametrium invasion. T2-T3 patients were treated with preoperative irradiation and bilateral hysterectomy. DFS was 90.5% vs. 72.2% and 2/2 vs. 3/7 when the lesion was understaged. The results of irradiation were similar to literature data, but 53% of patients (all in poor general conditions and/or very old) died from associated diseases. Relapses were observed in 13.6% of cases (62/444 patients); 29 (6%) were local recurrences and 33 (7.6%) were distant metastases, which correlated well with recurrences and 33 (7.6%) were distant metastases, which correlated well with risk factors. Severe complication (G3) were observed in 6.3% of cases.
authors.affiliation: Fondazione Pinna Pintor, Torino.
authors.forename: G
authors.initials: G
authors.lastname: Sinistrero
authors.forename: P
authors.initials: P
authors.lastname: Sismondi
authors.forename: P
authors.initials: P
authors.lastname: Zola
authors.forename: S
authors.initials: S
authors.lastname: Gribaudo
authors.forename: S
authors.initials: S
authors.lastname: Danese
authors.forename: M G
authors.initials: MG
authors.lastname: Bellora
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate
vernacular_title: Sopravvivenza e recidive dell'adenocarcinoma dell'endometrio.