Cutaneous involvement in chronic myelomonocytic leukemia.
BACKGROUND
Chronic myelomonocytic leukemia has been associated with various nonspecific cutaneous manifestations. Rarely has the leukemia been reported to directly affect the skin.


METHODS
This case documents the progression of a patient who ultimately developed chronic myelomonocytic leukemia, by clinical examination, hematologic parameters, dermatopathology, and bone marrow pathology.


RESULTS
The skin showed nonspecific cutaneous involvement, progressing to specific leukemic lesions parallel with increasing systemic and hematologic involvement.


CONCLUSIONS
Chronic myelomonocytic leukemia can manifest with lesions of leukemia cutis. The possibility of nonspecific cutaneous involvement in the preleukemic phase exists.
O'Connell
D M
DM
Department of Dermatology, University of Texas Health Science Center, San Antonio 78284-7876.
Fagan
W A
WA
Skinner
S M
SM
Pulitzer
D R
DR
Devillez
R L
RL
D001706:Biopsy; D001772:Blood Cell Count; D017809:Fatal Outcome; D006403:Hematologic Tests; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy