Synthesis and antimicrobial activity of dihydrofurobenzoxazolin-2(3H)-ones and their derivatives.
A series of dihydrofurobenzoxazolin-2(3H)-ones and their derivatives were synthesized. The structures of the compounds have been elucidated by IR, mass, 1H-NMR spectra and elementary analysis. The in vitro activity of these compounds was investigated against Gram-positive and Gram-negative bacteria and also against Candida albicans. 7,7-Dimethyl-7,8-dihydro-furo[2,3-g]benzoxazolin-2(3H)-one (compound 2) proved to be more potent than compound 1. Compound 3 also showed significant activity against all the microbes tested. Compounds 4 and 5 were more effective against Gram-positive bacteria than Gram-negative bacteria but inactive against C. albicans.
Bhalerao
U T
UT
Organic Division II, Indian Institute of Chemical Technology, Hyderabad.
Gawali
B B
BB
Annapurna
J
J
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001583:Benzoxazoles; D005663:Furans