Hemolysis and autoantibodies to triosephosphate isomerase in a patient with acute hepatitis A virus infection.
Having returned from a holiday in Southeast Europe, a 30-year-old German woman developed acute hepatitis. Hepatitis A virus (HAV) infection was diagnosed serologically. During the course of the infection, hemolysis was found. IgM antibodies against triosephosphate isomerase (IgM anti-TPI) were detected in the patient's serum from the acute phase of the HAV infection. Affinity purified IgM anti-TPI from the serum reduced the enzyme activity in vitro and caused an increased 51Cr release from erythrocytes. IgM anti-TPI is assumed to be one of the causative agents of hemolysis in HAV infection.
Ritter
K
K
Department of Medical Microbiology, Georg-August-University of Göttingen, Germany.
Uy
A
A
Ritter
S
S
Thomssen
R
R
D000208:Acute Disease; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006461:Hemolysis / Q000276:immunology*; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000032:analysis; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D014305:Triose-Phosphate Isomerase / Q000276:immunology*
D001323:Autoantibodies; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies; D007075:Immunoglobulin M; D014305:Triose-Phosphate Isomerase