title: The nucleotide sequence of TTP1, a gene encoding a predicted type II membrane protein.
abstract: The DNA sequence of a 2967 bp fragment located near the centromere of chromosome II, between the CEN2 and FUR4 genes, was determined. The segment contains a new open reading frame of 1794 bp. The product encoded by the gene, designated TTP1, is a predicted type II membrane protein of 597 amino acid residues with a short cytoplasmic NH2-terminus, a membrane-spanning region and a large COOH-terminal region containing three potential N-glycosylation sites. Gene disruption indicated that TTP1 is not essential for cell growth.
authors.affiliation: McGill Cancer Centre, McGill University, Montréal, Québec, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Romero
authors.forename: A
authors.initials: A
authors.lastname: Athanassiadis
authors.forename: M
authors.initials: M
authors.lastname: Lussier
authors.forename: A
authors.initials: A
authors.lastname: Herscovics
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics*; D015698:Genomic Library; D008364:Mannosyltransferases; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D016296:Mutagenesis; D011487:Protein Conformation; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D017422:Sequence Analysis, DNA
chemical_list: D005656:Fungal Proteins; D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins; C090871:MNN2 protein, S cerevisiae; D008364:Mannosyltransferases