Expoxidation of styrene and substituted styrenes by whole cells of Mycobacterium sp. M156.
Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. alpha-Methylstyrene was also epoxidised at a lower rate, while trans-beta-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.
Rigby
S R
SR
ZENECA Bio Products, Billingham, Cleveland, U.K.
Matthews
C S
CS
Leak
D J
DJ
D001711:Biotransformation; D002849:Chromatography, Gas; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D007700:Kinetics; D009161:Mycobacterium / Q000378:metabolism*; D009904:Optical Rotation; D013237:Stereoisomerism; D020058:Styrene; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D004852:Epoxy Compounds; D013343:Styrenes; D020058:Styrene; C013690:styrene oxide