[Influence of atrial fibrillation in the natural history of hypertrophic cardiomyopathy].
OBJECTIVE
To evaluate the influence of atrial fibrillation in the natural history of hypertrophic cardiomyopathy.


METHODS
Eighty-eight patients under ambulatory treatment were studied. Most of them presented the asymmetric type of hypertrophic cardiomyopathy (87.5%). Group I (77 cases) was formed by patients who had never had atrial fibrillation and group II (11 cases) by those who had this arrhythmia paroxysmal or established.


RESULTS
In group I, with ages 48.02 +/- 14.82 years, left atrial dimensions 4.21 +/- 0.66 cm, there was one sudden death; 69 were treated by clinical means and 7 by surgery; no patient developed thromboembolism neither cardiac failure. In group II, with ages 58.02 +/- 11.04 years and left atrial dimension 5.32 +/- 0.45 cm, there were 4 deaths, 4 thromboembolisms and 3 with cardiac failure; all received only clinical treatment, having improved in clinical status in 71.42% after amiodarone therapy.


CONCLUSIONS
Atrial fibrillation was present in 12.5%, mostly in the asymmetric type, and in patients after 5th decade, all of them with enlarged left atrium (> 4.7 cm), with highest morbidity (thromboembolism and cardiac failure) and mortality. Among the survivors, amiodarone therapy improved functional class in 71.42%.
Albanesi Filho
F M
FM
Hospital Universitário Pedro Ernesto-UERJ, Rio de Janeiro.
Girardi
J M
JM
Castier
M B
MB
Ginefra
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000638:Amiodarone / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000638:Amiodarone
Influência da fibrilação atrial na história natural da cardiomiopatia hipertrófica.