title: [Silicosis and primary Gougerot-Sjögren syndrome].
abstract: We report three cases of primary Sjögren's syndrome in silicotic coal miners. All patients fulfilled the diagnostic criteria for Sjögren's syndrome recently established by the European Community study group. One patient had cryoglobulinemia and polynevritis. Another had Raynaud's phenomenon, arthralgia, purpura and polynevritis. Capillary microscopy was normal in all the three patients. Antinuclear antibodies were detected only in one patient, who had also anti-SSa and anti-SSb antibodies. The prevalence of systemic sclerosis, rheumatoid arthritis and probably systemic lupus erythematosus is significantly higher after longstanding occupational exposure to silica. On the contrary, any case of Sjögren's syndrome was till now described in the course of pulmonary silicosis. The physiopathological mechanisms of these associations are misunderstood.
authors.affiliation: Service de médecine interne, hôpital Claude-Huriez, CHRU, Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Puisieux
authors.forename: E
authors.initials: E
authors.lastname: Hachulla
authors.forename: M
authors.initials: M
authors.lastname: Brouillard
authors.forename: P Y
authors.initials: PY
authors.lastname: Hatron
authors.forename: B
authors.initials: B
authors.lastname: Devulder
mesh_terms: D000368:Aged; D000874:Anthracosilicosis / Q000150:complications* / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000503:physiopathology
vernacular_title: Silicose et syndrome de Gougerot-Sjögren primitif.