Brain atriopeptin mediates AV3V depressor response.
In urethane-anesthetized rats, sodium L-glutamate (Glu) microinjection into the anteroventral third ventricle region (AV3V) induced a depressor response, but the heart rate remained unchanged, whereas Glu injection into its surrounding areas or normal saline injection into the AV3V had no effect on the arterial pressure and heart rate. Bilateral preinjection of procaine or atriopeptin III antiserum into the nucleus paraventricularis (NPV) and methyl atropine (IV) markedly attenuated the AV3V depressor response, but the hypotensive response was not significantly affected by phentolamine or propranolol (IV), indicating that atriopeptin in the NPV mediates the AV3V depressor response, and excitation of the cardiac vagus is also involved in this response.
Ku
Y H
YH
Department of Physiology, Beijing Medical University, China.
Zhang
T
T
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000276:immunology / Q000378:metabolism*; D001286:Atropine Derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000187:drug effects*; D004347:Drug Interactions; D007022:Hypotension / Q000139:chemically induced; D007031:Hypothalamus; D007276:Injections, Intraventricular; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects*; D010446:Peptide Fragments; D010646:Phentolamine / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology*
D001286:Atropine Derivatives; D010446:Peptide Fragments; C062525:atrial natriuretic factor prohormone (103-126); D011343:Procaine; C006649:methylatropine; D009320:Atrial Natriuretic Factor; D011433:Propranolol; D012970:Sodium Glutamate; D010646:Phentolamine