title: Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment.
abstract: The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago.
authors.forename: R P
authors.initials: RP
authors.lastname: Sharma
authors.forename: G
authors.initials: G
authors.lastname: Bissette
authors.forename: P
authors.initials: P
authors.lastname: Janicak
authors.forename: J M
authors.initials: JM
authors.lastname: Davis
authors.forename: C B
authors.initials: CB
authors.lastname: Nemeroff
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D012016:Reference Values; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013004:Somatostatin / Q000134:cerebrospinal fluid*
chemical_list: D014150:Antipsychotic Agents; D013004:Somatostatin