Inhibition of the growth of influenza viruses in vitro by 4-guanidino-2,4-dideoxy-N-acetylneuraminic acid.
The sialidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N- acetylneuraminic acid was tested for growth inhibitory effects against a panel of avian influenza A viruses encompassing all nine neuraminidase subtypes. Growth in tissue culture of viruses from each subtype was inhibited by this compound at concentrations within a range previously found effective against human N1 and N2 viruses. This compound may prove a selective agent for the treatment (and prevention) of influenza virus infections.
Thomas
G P
GP
AFRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.
Forsyth
M
M
Penn
C R
CR
McCauley
J W
JW
D000998:Antiviral Agents / Q000494:pharmacology*; D006146:Guanidines; D009980:Influenza A virus / Q000187:drug effects* / Q000254:growth & development*; D011714:Pyrans; D012794:Sialic Acids / Q000494:pharmacology*; D010948:Viral Plaque Assay; D053243:Zanamivir
D000998:Antiviral Agents; D006146:Guanidines; D011714:Pyrans; D012794:Sialic Acids; D053243:Zanamivir