title: [A clinical study of sixteen polycythemia vera cases--acute myeloblastic leukemia in patients with polycythemia vera].
abstract: The clinical course of 16 patients with polycythemia vera (PV), treated in the period 1982 to 1993, was shown. Splenomegaly occurred in three fourths of these patients (75%), and hypertension was a major symptom. Thrombosis such as myocardial infarction and cerebral infarction was noted. Eight patients was treated with myelosuppressive agents and the 8 other patients were treated with phlebotomy. A 70-year-old male who was treated with mitobronitol (DBM) developed acute myeloblastic leukemia (AML) 11 years later. He was treated with multi-combination chemotherapy (BHAC-DMP), and entered complete remission, followed by early relapse. He became refractory to chemotherapy and died of acute pneumonia 6 months later. Median survival of 16 cases of PV was more than 10 years, and long-term treatment and care are necessary.
authors.affiliation: Dept. of Internal Medicine, Nagoya Ekisaikai Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Takeyama
authors.forename: T
authors.initials: T
authors.lastname: Shimokawa
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: E
authors.initials: E
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008927:Mitobronitol / Q000008:administration & dosage; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D011087:Polycythemia Vera / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis
chemical_list: D009607:Nitrosourea Compounds; D008927:Mitobronitol; C020766:ranimustine