title: [Structure-activity changes in human hemoglobin induced by UV-light and serotonin].
abstract: Basic indices of oxygen-binding properties of the human hemoglobin solutions modified by the UV-light (240-390 nm) in dose range 151-604 J/m2 together with serotonin (10(-5)-10(-3) mol/l) have been analysed by means of spectrophotometry registration of the oxyhemoglobin dissociation curves. In these conditions biogenic amine displays maximum photoprotective effect at the concentration 4 x 10(-4) mol/l. At the highest concentrations serotonin exert photosensibilitive that influences the course of the protein molecule disorganisation. It has been demonstrated that three-dimensional surfaces analysis can be used to forecast the influence of the serotonin photoprotection on the hemoglobin functional activity.
authors.forename: G A
authors.initials: GA
authors.lastname: Vashanov
authors.forename: V G
authors.initials: VG
authors.lastname: Artiukhov
mesh_terms: D006454:Hemoglobins / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
chemical_list: D006454:Hemoglobins; D012701:Serotonin; D010100:Oxygen
vernacular_title: Strukturno-funktsional'nye izmeneniia gemoglobina cheloveka, indutsirovannye UF-svetom i serotoninom.