Vascular impedance analysis in dog lung with detailed morphometric and elasticity data.
On the basis of experimentally measured morphometric and elasticity data and model-derived mean pressure-flow conditions, we attempt a theoretical modeling of pulsatile flow in the whole lung. In the model we use the "elastic tube" for arteries and veins, and the vascular impedance in arteries and veins follows Womersley's theory and electric analogue. We employ the "sheet-flow" theory to describe the flow in the capillaries and to obtain the microvascular impedance matrix. The characteristic impedance of each order along the vascular tree, the input impedance at the capillary entrance and exit, and the pulmonary arterial input impedance at the main pulmonary artery are computed under certain physiological conditions. Using the pulsatile flow model, we investigate the effects of arterial vascular obstruction on pulmonary vascular impedance. The model-derived data are compared with the available experimental results in the literature.
Gan
R Z
RZ
Department of Biomedical Engineering, Memphis State University, Tennessee 38152.
Yen
R T
RT
D000818:Animals; D002196:Capillaries / Q000502:physiology; D004285:Dogs; D004548:Elasticity; D006400:Hematocrit; D008168:Lung / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D008170:Lung Compliance / Q000502:physiology; D008954:Models, Biological; D011651:Pulmonary Artery / Q000033:anatomy & histology / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology*; D011667:Pulmonary Veins / Q000033:anatomy & histology / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology*