Modelling the impact of mass vaccination against hepatitis B. I. Model formulation and parameter estimation.
A new model of the transmission dynamics of hepatitis B virus in countries with high transmission rates is presented. The model is age and sex stratified, and includes details of host demography. Details of hepatitis B natural history, such as the existence of infectious and non-infectious carriers, are included. The biological assumptions of the model are discussed in full and related to the model's equations. Hepatitis B epidemiological data is reviewed with special emphasis on the estimation of model parameter values from field data. A full set of model parameter values are derived. Possible uses of the model in the assessment of strategies of mass vaccination are discussed.
McLean
A R
AR
Zoology Department, Oxford University, U.K.
Blumberg
B S
BS
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015981:Epidemiologic Factors; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D017325:Hepatitis B Vaccines / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012737:Sex Factors; D014611:Vaccination
D017325:Hepatitis B Vaccines