The value of ploidy in the prognosis of the colorectal cancer.
Between the prognostic indices in the colorectal cancer the ploidy has determined a great interest. To study the value of ploidy in the prognosis of the colorectal cancer, as a sign of the aggressiveness of the tumor for a therapeutic help, we have examined, in a retrospective study, 150 patients who had a colorectal cancer resected from 1980 to 1986. We have compared ploidy of specimens of paraffin-embedded tumors and Dukes' stage, Grading, the over-all, distal and local recurrence and the survival at 5 years. The statistics were performed by the chi-square test, the Fisher exact-test and the Wilcoxon test. The aneuploids are 126 (84%) and the diploids 24 (16%). The correlations of ploidy and the Duke's stages, the Grading, and the over-all and local recurrence are not statistical significant. The distal recurrence of the aneuploids and the better survival of the diploids are significant. In conclusion the ploidy is only a generic indicator of the aggressiveness of the tumor, not useful for a more complete therapeutic choice.
Foggi
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Istituto Policattedra di Clinica Chirurgica Generale, Toracica e Vascolare, Università degli Studi di Parma.
Carbognani
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D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D004171:Diploidy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors