Myasthenia gravis: pathogenesis and treatment.
Much is known about the pathogenesis of MG. This information has provided a rational basis for treatment of the disease, which is very effective. On the other hand, present treatments are limited by significant adverse effects. Our knowledge of pathogenesis also provides clues for the development of new, effective, but less toxic treatments. In addition, knowledge of the autoimmune mechanisms in MG may be useful in devising better treatments for the many human autoimmune diseases that are less well understood.
Richman
D P
DP
Department of Neurology, University of California, Davis 95616.
Agius
M A
MA
D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D006801:Humans; D007114:Immunization / Q000009:adverse effects; D009157:Myasthenia Gravis / Q000276:immunology* / Q000628:therapy; D009469:Neuromuscular Junction / Q000276:immunology*; D011978:Receptors, Nicotinic / Q000276:immunology*; D009435:Synaptic Transmission / Q000276:immunology
D011978:Receptors, Nicotinic