[Cephradine delivery into the eye with domestic collagen shield].
The author reports that enhancement by the native made collagen-shield on the permeation of cephradine into the eye is 1.5 times and 1.3 times versus controls when the corneal epithelium is intact or defect, and is 10 times versus frequent eyedrops instillation. On the other hand, the enhancement of the collagen-shield is about the same as that of the soft contact lens impregnated with cephradine solution, but the drug concentration in aqueous humor is increased by collagen-shield 1-2 times than that by the wet soft contact lens. These results indicate that the collagen-shield can effectively increase the drug concentration in aqueous humor.
Wang
J M
JM
Eye Research Institute, Shanghai Medical University.
Chu
R Y
RY
Li
Y T
YT
D000818:Animals; D001082:Aqueous Humor; D002515:Cephradine / Q000008:administration & dosage* / Q000627:therapeutic use; D003094:Collagen; D003261:Contact Lenses; D004337:Drug Carriers; D016503:Drug Delivery Systems; D009883:Ophthalmic Solutions; D011817:Rabbits
D004337:Drug Carriers; D009883:Ophthalmic Solutions; D003094:Collagen; D002515:Cephradine