Ketorolac induced acute renal failure following a single dose.
Acute and chronic impairment of renal function have been reported as complications of therapy with nonsteroidal anti-inflammatory agents. Renal prostaglandins play an increasingly important role in maintaining renal function when there is decreased renal blood perfusion. We describe a case of rapidly appearing acute renal failure following a single intramuscular dose of ketorolac.
Quan
D J
DJ
Division of Clinical Pharmacy, University of California, San Francisco 94143-0622.
Kayser
S R
SR
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D017147:Defibrillators, Implantable; D004298:Dopamine / Q000627:therapeutic use; D004338:Drug Combinations; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D020911:Ketorolac Tromethamine; D008297:Male; D008788:Metolazone / Q000627:therapeutic use; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006435:Renal Dialysis; D014046:Tolmetin / Q000009:adverse effects / Q000031:analogs & derivatives*; D014325:Tromethamine / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D005665:Furosemide; D003404:Creatinine; D014046:Tolmetin; D008788:Metolazone; D004298:Dopamine