Gastric emptying of liquid meals measured noninvasively in humans with [13C]acetate breath test.
The aim of the present study was to develop a breath test to measure liquid gastric emptying rates that would be without radiation exposure and applicable to field testing. Four different test meals were investigated: a glucose meal, an amino acid meal, a fat meal, and a mixed meal (Ensure). The test meals were labeled with two markers, [13C]acetate and PEG-4000 (polyethylene glycol 4000). Gastric emptying rates were measured simultaneously by both breath test and the double-indicator technique in eight healthy male subjects. The appearance of 13CO2 in the breath closely reflected gastric emptying of the four test meals as measured by the double-indicator technique. It is concluded that the [13C]acetate breath test is a reliable, noninvasive test to measure gastric emptying rates of liquid test meals.
Mossi
S
S
Division of Gastroenterology, University Hospital, Basel, Switzerland.
Meyer-Wyss
B
B
Beglinger
C
C
Schwizer
W
W
Fried
M
M
Ajami
A
A
Brignoli
R
R
D000085:Acetates; D000328:Adult; D001944:Breath Tests; D002247:Carbon Isotopes; D005217:Fat Emulsions, Intravenous; D005526:Food, Formulated; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D011092:Polyethylene Glycols; D015203:Reproducibility of Results
D000085:Acetates; D002247:Carbon Isotopes; D005217:Fat Emulsions, Intravenous; D011092:Polyethylene Glycols