Production of PEG-modified bovine hemoglobin: economics and feasibility.
Bovine hemoglobin has many advantages as a blood substitute: a) it's ready availability; b) it's low cost; c) it's oxygen carrying capacity; and d) the ease with which it can be modified with polyethylene glycol (PEG) to improve its pharmacokinetic profile. This study investigates the potential of PEG-modified bovine hemoglobin as a cost-effective blood substitute.
Bradley
R
R
Enzon, Inc., Piscataway, NJ 08854.
Sloshberg
S
S
Nho
K
K
Czuba
B
B
Szesko
D
D
Shorr
R
R
D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000191:economics* / Q000302:isolation & purification*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D003362:Cost-Benefit Analysis; D004340:Drug Contamination; D004355:Drug Stability; D004731:Endotoxins / Q000032:analysis; D005078:Exchange Transfusion, Whole Blood; D006454:Hemoglobins / Q000302:isolation & purification* / Q000378:metabolism; D006456:Hemoglobinuria / Q000209:etiology; D006801:Humans; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000032:analysis; D010100:Oxygen / Q000378:metabolism; D011092:Polyethylene Glycols; D051381:Rats; D012769:Shock / Q000378:metabolism / Q000628:therapy
D001802:Blood Substitutes; D004731:Endotoxins; D006454:Hemoglobins; D011092:Polyethylene Glycols; D008706:Methemoglobin; D010100:Oxygen