Determination of methaqualone and its metabolites in urine and blood by UV, GC/FID and GC/MS.
A systematic procedure for the determination of methaqualone and its metabolites in blood and urine by UV spectrophotometry, GC and GC/MS was developed. Urine and blood samples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase and liquid-liquid extractions were used in the extraction and clean-up of the samples. The total amount of methaqualone and its metabolites was measured by UV spectrophotometry. The amount of parent methaqualone was quantitated by GC/FID. Methaqualone and its 10 metabolites including two acetyl metabolites were found in urine and blood. This procedure is useful for monitoring drugs in emergency treatment.
Liu
F
F
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
Liu
Y T
YT
Feng
C L
CL
Luo
Y
Y
D002849:Chromatography, Gas; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D008702:Methaqualone / Q000032:analysis* / Q000378:metabolism* / Q000506:poisoning; D008875:Middle Aged; D013056:Spectrophotometry, Ultraviolet; D013406:Suicide, Attempted
D008702:Methaqualone