[Virus inactivated plasma].
Two different virus inactivated plasma preparations are available in Germany. Methylene blue ephotoxidized (MB) plasma is plasma from a single donation, which is photoxidized using 1 microM methylene blue and visible light (1 hour 60,000 Lux). Photochemical inactivation reduces HIV by at least 5 log10, but also fibrinogen is altered. To date, the clinical significance of this finding is still unclear, since prospective clinical studies are lacking. Solvent detergent (SD) plasma is manufactured from a pool of about 2000 plasma donations, and triton-X-100 and tri-n-butyl-phosphate (TNBP) are added for virus inactivation. HIV and hepatitis viruses are thus reduced by 5 to 6 log10. SD treatment reduces protein S and alpha-2-antiplasmin by about 40%. Clinical studies have already demonstrated, that SD plasma is comparable with untreated, native fresh frozen plasma in terms of efficacy.
Köhler
M
M
Abteilung Transfusionsmedizin, Klinik der Universität Göttingen.
Wieding
J U
JU
D001803:Blood Transfusion; D017848:Blood-Borne Pathogens; D003902:Detergents; D006678:HIV / Q000187:drug effects / Q000528:radiation effects; D006518:Hepatitis Viruses / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008027:Light; D008751:Methylene Blue; D010949:Plasma / Q000821:virology*; D012307:Risk Factors
D003902:Detergents; D008751:Methylene Blue
Virusinaktiviertes Plasma.