Acute myeloblastic leukemia with a pericentric inversion of chromosome 6 in a child with Down syndrome.
Cytogenetic analysis of bone marrow cells demonstrated a pericentric inversion of chromosome 6 when acute myeloblastic leukemia (AML) was diagnosed in a 15-month-old child with Down syndrome. The abnormal clone with inv(6)(p24q16) was associated with FAB-M1 AML and disappeared when a complete remission was achieved. This is a unique cytogenetic abnormality for FAB-M1 AML in a child with Down syndrome and, to our knowledge, is only the second case of a pericentric inversion of chromosome 6 reported in AML.
Shekhter-Levin
S
S
Department of Human Genetics, University of Pittsburgh, Children's Hospital of Pittsburgh, Pennsylvania.
Mirro
J
J
Penchansky
L
L
Sherer
M E
ME
Wald
N
N
Gollin
S M
SM
D007446:Chromosome Inversion; D002896:Chromosomes, Human, Pair 6; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008297:Male