B-cell acute lymphoblastic leukemia with L1 morphology and coexistence of t(1;19) and t(14;18) chromosome translocations.
We report a case of adult de novo acute lymphoblastic leukemia (ALL) with unique cytogenetic abnormalities and discrepant morphologic and immunologic features. Morphology was L1 by the French-American-British classification, but flow cytometry was consistent with a mature B-cell phenotype. Cytogenetic analysis showed numerous chromosome abnormalities nonspecific for lymphoid neoplasm except for t(1;19) and t(14;18). The former is characteristic of pre-B-ALL and the latter is characteristic of follicular lymphoma. This is the first report of these two translocations occurring concurrently in ALL.
Kouides
P A
PA
Strong Memorial Hospital, Rochester, New York.
Phatak
P D
PD
Wang
N
N
Bennett
J M
JM
D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D008875:Middle Aged; D014178:Translocation, Genetic