title: C3 nephritic factor and SLE: report of four cases and review of the literature.
abstract: We present four patients with C3 nephritic factor associated with partial lipodystrophy and/or mesangiocapillary glomerulonephritis type II. Each of these patients subsequently developed features of SLE, with an onset between 2 and 24 years after the development of the lipodystrophy or glomerulonephritis. All four patients had antinuclear antibodies and three of the four had anti-Ro antibodies. These patients bring to six the number of reported cases of this association. Possible explanations for the link between these two conditions are discussed.
authors.affiliation: Department of Medicine, RPMS, Hammersmith Hospital, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Walport
authors.forename: K A
authors.initials: KA
authors.lastname: Davies
authors.forename: M
authors.initials: M
authors.lastname: Botto
authors.forename: M A
authors.initials: MA
authors.lastname: Naughton
authors.forename: D A
authors.initials: DA
authors.lastname: Isenberg
authors.forename: D
authors.initials: D
authors.lastname: Biasi
authors.forename: R J
authors.initials: RJ
authors.lastname: Powell
authors.forename: N T
authors.initials: NT
authors.lastname: Cheung
authors.forename: G R
authors.initials: GR
authors.lastname: Struthers
mesh_terms: D000328:Adult; D003178:Complement C3 Nephritic Factor / Q000378:metabolism*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications*; D006801:Humans; D008060:Lipodystrophy / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008297:Male
chemical_list: D003178:Complement C3 Nephritic Factor