The development of a valveless cardiac assist device attached to the ventricular apex.
Konstantinov et al, in October, 1991, published a novel way to bridge a patient for heart transplantation. They proposed to cut off both ventricles high under the atrioventricular groove, leaving the atria, aorta, and pulmonary artery and their valves intact and to attach pneumatically driven, valveless pulsating pouches to assist the heart until a donor could be found. The removal of the ventricles just below the atrioventricular groove is called the "high cut"; it, however, destroys the chordae tendineae rendering the mitral and tricuspid valves insufficient. These have to be replaced by tissue inflow valves. We chose to cut off the ventricles at a lower level (the "low cut") to leave the papillary muscles on both sides intact, thereby saving the integrity of the mitral and tricuspid valves. Pulsating pouches were made to fit the heart at this lower level. They can be easily connected to the remaining heart after a specially disigned cuff has been sutured over the ventricular stumps. The pouches were pumped during the systole of the natural heart, but the myocardium may have to be electrically stimulated during systole to prevent undue distension. If the turgor is too weak to prevent distension, a sleeve over the ventricles is provided. To find the best location for these pouches, human cadaver implantations were done and the pre peritoneal cavity was found to be the most suitable. In vitro testing to determine how much flow could be pumped was done by attaching the pouches to fresh pig hearts and connecting them to a double sided mock circulation.(ABSTRACT TRUNCATED AT 250 WORDS)
van Loon
J
J
University of Utah, Salt Lake City 84112.
Wilde
J C
JC
Topaz
S R
SR
Bishop
N D
ND
Shelton
A
A
Marten
C
C
Pantalos
G
G
Kolff
W J
WJ
Thomas
G
G
Nakajima
H
H
D002302:Cardiac Output; D004867:Equipment Design; D006339:Heart Rate / Q000502:physiology; D016027:Heart Transplantation; D006351:Heart Valves; D006352:Heart Ventricles / Q000503:physiopathology / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D011300:Preoperative Care; D013318:Stroke Volume / Q000502:physiology; D016276:Ventricular Function / Q000502:physiology