[Systemic manifestations of rheumatoid arthritis: prognostic value of the HLA DRB1 0405 allele].
The aim of the present study was to determine HLA DRB1* genotype by PCR-RFLP analysis in patients with rheumatoid arthritis (N = 122) associated with extra-articular manifestations (N = 24). A significant increased of DRB1* 0405 was found in RA patients with extra-cellular involvement (odd-ratio = 8.33, confidence interval = 1.44 - 56.7). In patients with RA, HLA DRB1*0405 allele might constitute a susceptibility marker of extra-articular involvement such as vasulitis or cardio-pulmonary manifestations.
Flipo
R M
RM
Service de rhumatologie, hôpital B, CHRU de Lille.
Danze
P M
PM
Castelain
V
V
Coquerel
P
P
Duquesnoy
B
B
Rousseaux
J
J
Delcambre
B
B
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000503:physiopathology; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D011379:Prognosis
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II
Manifestations systémiques de la polyarthrite rhumatoïde: valeur pronostique de l'allèle HLA DRB1*0405.