title: Automated interpretation of planar thallium-201-dipyridamole stress-redistribution scintigrams using artificial neural networks.
abstract: To develop an automated image interpretation system of planar cardiac 201Tl dipyridamole stress/redistribution scintigrams, the authors used artificial neural networks that associate patterns of segmental myocardial thallium uptake with a diagnostic assessment about the presence, severity and localization of significant coronary artery disease.
  
  
  METHODS
  Artificial neural networks were trained and evaluated using the results from segmental thallium analysis and either expert readings in 159 cases or coronary angiography in a subgroup of 81 patients.
  
  
  RESULTS
  Based on receiver operating characteristics analysis, the sensitivity for the detection of significant coronary artery disease at a specificity of 90% was 51% compared with angiography and 72% compared with the human expert. For severity and localization of disease, two vascular territories assigned to the vascular bed of the left anterior descending (LAD) artery and to the territory subtended by the left circumflex artery and the right coronary artery together (CX/RCA) were included in the analysis.
  
  
  CONCLUSIONS
  Artificial neural networks may be useful to develop automated computer-based image interpretation systems of 201Tl perfusion scintigrams. However, utilization of large training datasets appears to be a prerequisite to achieve adequate diagnostic performance.
authors.affiliation: Department of Cardiology, University of Vienna Medical School, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Porenta
authors.forename: G
authors.initials: G
authors.lastname: Dorffner
authors.forename: S
authors.initials: S
authors.lastname: Kundrat
authors.forename: P
authors.initials: P
authors.lastname: Petta
authors.forename: J
authors.initials: J
authors.lastname: Duit-Schedlmayer
authors.forename: H
authors.initials: H
authors.lastname: Sochor
mesh_terms: D000328:Adult; D000368:Aged; D001331:Automation; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004176:Dipyridamole / Q000493:pharmacokinetics; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D012189:Retrospective Studies; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed
chemical_list: D013794:Thallium Radioisotopes; D004176:Dipyridamole