[In vitro study about the influence of recombinant interleukin-8 on human hematopoiesis].
The influence of the recombinant human Interleukin-8 (IL-8) on in vitro clonogenicity of human bone marrow progenitors from the different haemopoietic lineages has been evaluated. Two different forms of IL-8 were used in this study: the longer one of the endothelial and shorter one of the monocytic origin. The bone marrow cells before the plating were enriched in CD34+ cells. We did not confirm that endothelial derived IL-8 inhibits the CFU-GM, BFU-E and CFU-Meg colony formation. Similarly monocytic IL-8 did nor inhibit neither the CFU-GM not the BFU-E colony growth. Nevertheless, small inhibitory effect of monocytic derived IL-8 have been found on the CFU-Meg colony formation.
Ratajczak
J
J
Zakładu Immunologii CSK WAM.
Ratajczak
M Z
MZ
D002999:Clone Cells; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D016209:Interleukin-8 / Q000502:physiology*; D011994:Recombinant Proteins
D016209:Interleukin-8; D011994:Recombinant Proteins
Badania in vitro nad wpływem rekombinowanej interleukiny-8 na ludzka hemopoeze.