title: [Hemodynamic and metabolic effects of noradrenaline infusion in a case of hyperdynamic septic shock].
abstract: OBJECTIVE
  To evaluate the effect of noradrenaline infusion in a case of hyperdynamic septic shock refractory to volume loading, dopamine and dobutamine, on hemodynamic parameters, oxygen transport, lactate and pyruvate levels.
  
  
  METHODS
  Description of a clinical case.
  
  
  METHODS
  Postsurgical Intensive Care Unit in a University Hospital.
  
  
  METHODS
  A 48-year-old woman with symptoms of peritonitis due to Enterobacter Agglomerans and refractory hyperdynamic septic shock.
  
  
  METHODS
  Administration of noradrenaline in doses ranging from 0.03 to 0.14 micrograms/kg/min.
  
  
  RESULTS
  Before and after noradrenaline infusion the following were evaluated: hemodynamic (parameters) and oxygen transport acid-base status, arterial blood levels of lactate and pyruvate, and lactate/pyruvate ratio. During the administration of noradrenaline an increase was observed over time in oxygen consumption (from 110 +/- 16 to 164 +/- 19 mL/min/m2; p < 0.01), peripheral vascular resistance (from 509 +/- 95 to 1172 +/- 384 dynes.sec.cm-5, p < 0.01) and the oxygen extraction index (from 12.9 +/- 2.1 to 21.2 +/- 2.9%, p < 0.01), together with reduced lactate (from 24.4 +/- 1.5 to 4.9 +/- 5.1 mmol/L) and pyruvate levels (from 945 +/- 62 to 357 +/- 174 mumol/L; p < 0.01) and a reduced lactate/pyruvate ratio (from 26.2 +/- 1.2 to 11.8 +/- 5.9, p < 0.01). No significant increases were found in cardiac output and oxygen delivery.
  
  
  CONCLUSIONS
  In the case observed here the infusion of noradrenaline induced an increase in oxygen consumption and the oxygen extraction index associated with a reduction in the lactate/pyruvate ratio and the normalisation of the acid-base status. These changes were not associated with an increase in oxygen which remained delivery > or = 600 mL/min/m2.
authors.affiliation: Istituto di Clinica Chirurgica, Scuola di Specializzazione, in Anestesia e Rianimazione, Università degli Studi di Pisa.
authors.forename: L S
authors.initials: LS
authors.lastname: Brandi
authors.forename: A M
authors.initials: AM
authors.lastname: Sironi
authors.forename: R
authors.initials: R
authors.lastname: Baldassari
authors.forename: F
authors.initials: F
authors.lastname: Benanti
authors.forename: F
authors.initials: F
authors.lastname: Giunta
mesh_terms: D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D012772:Shock, Septic / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D009638:Norepinephrine
vernacular_title: Effetti emodinamici e metabolici della infusione di noradrenalina in un caso di shock settico iperdinamico.