[A comparative study of the effect of allopurinol and caffeine on mitotic cycle recovery in cells after x-ray irradiation].
Alterations in the duration of mitotic cycle phases in X-irradiated HeLa cells after caffeine (CF) of allopurinol (AP) treatment are studied. Delays in S- and G2-phases, induced by 5 Gr of X-rays, are partially (1 mM) or completely (5 mM) decreased by both AP and CF. When the agent is removed from the medium, the delays are seen again. The data obtained enabled us to suggest a possible use of AP as a radiosensitizer in X-therapy of cancer transformations.
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D000493:Allopurinol / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D008938:Mitosis / Q000187:drug effects* / Q000528:radiation effects*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013997:Time Factors
D011838:Radiation-Sensitizing Agents; D002110:Caffeine; D000493:Allopurinol; D004247:DNA
Sravnitel'noe issledovanie vliianiia allopurinola i kofeina na vosstanovlenie mitoticheskogo tsikla v kletkakh posle rentgenovskogo oblucheniia.