Increased level of serum HLA class I antigens in HIV infection. Correlation with disease progression.
Analysis of (sHLA-I) antigens in a large number of HIV-positive subjects found a significant increase of their level, but did not detect any change in their molecular profile. Monitoring at yearly intervals for four years of the sHLA-I antigen level in 14 HIV-positive subjects with a normal sHLA-I antigen level at study entry showed a significant correlation between progressive increase of sHLA-I antigen level and disease progression. Furthermore, a Kaplan-Meier plot of the frequency of development of AIDS in 34 patients whose cases were followed for 7 years showed that sHLA-I antigen level is a strong predictor of progression to AIDS. Its predictive value is comparable to that of serum beta 2-mu level, greater than that of serum neopterin, and lower than that of CD4+ T-cell percentage. The predictive value of sHLA-I antigen level in combination with serum beta 2-mu level, neopterin level, or CD4+ T-cell percentage is greater than that of each individual variable. These results suggest that measurement of the sHLA-I antigen level may provide useful prognostic information in HIV-positive subjects.
Puppo
F
F
Department of Internal Medicine, Medical School, University of Genoa, Italy.
Brenci
S
S
Lanza
L
L
Bosco
O
O
Imro
M A
MA
Scudeletti
M
M
Indiveri
F
F
Ferrone
S
S
D018791:CD4 Lymphocyte Count; D002478:Cells, Cultured; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood*; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans; D015151:Immunoblotting; D011233:Precipitin Tests
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I