title: Synthesis and antimicrobial activity of new 3,5-diaminoisothiazole derivatives.
abstract: The 3,5-diaminoisothiazole derivatives 23-42 were synthesized in excellent yields by oxidative cyclization of 3-amino-3-(dialkylamino)propenethioamide derivatives. These intermediates and the isothiazole derivatives were tested in vitro for their antimicrobial activity.
authors.forename: M T
authors.initials: MT
authors.lastname: Cocco
authors.forename: C
authors.initials: C
authors.lastname: Congiu
authors.forename: A
authors.initials: A
authors.lastname: Maccioni
authors.forename: V
authors.initials: V
authors.lastname: Onnis
authors.forename: M L
authors.initials: ML
authors.lastname: Schivo
authors.forename: A
authors.initials: A
authors.lastname: De Logu
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013844:Thiazoles