title: Intra-uterine insemination, cervical pregnancy and successful treatment with methotrexate.
abstract: Cervical pregnancy is rare but one of the most dangerous of all pregnancy complications. The aetiology of cervical implantation is unclear and because of the fear of profuse haemorrhage abdominal hysterectomy has been historically considered the standard therapy. We report here an unusual case of an infertile woman with cervical ectopic pregnancy after ovulation induction with gonadotrophins and intrauterine insemination. The patient was successfully treated with parenteral methotrexate without significant morbidity. It is concluded that chemotherapy should be initially considered in most cervical pregnancies either as the sole form of treatment or to improve the chances of success in alternative conservative measures.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Barcelona, Hospital Clínic i Provincial, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Balasch
authors.forename: J
authors.initials: J
authors.lastname: Peñarrubia
authors.forename: J L
authors.initials: JL
authors.lastname: Ballescá
authors.forename: M
authors.initials: M
authors.lastname: Creus
authors.forename: R
authors.initials: R
authors.lastname: Casamitjana
authors.forename: J A
authors.initials: JA
authors.lastname: Vanrell
mesh_terms: D000328:Adult; D002584:Cervix Uteri; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D007315:Insemination, Artificial; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D010062:Ovulation Induction; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*; D014592:Uterine Hemorrhage
chemical_list: D005640:Follicle Stimulating Hormone; D016729:Leuprolide; D008727:Methotrexate