title: Dissociation and complexation of fluoroquinolone analogues.
abstract: The dissociation and the complexation behaviours of four fluoroquinolone antibiotics have been studied. The acid dissociation constants of ciprofloxacin, enoxacin, norfloxacin and ofloxacin were determined by conventional potentiometric and conductometric techniques. Increasing the Hammett substituent constant, the pKa values were decreased. The absorption of fluoroquinolones in the intestinal tract are probably transported by pH-dependent mechanisms. Formation constants of the iron(III) complexes (1:1) of the fluoroquinolone analogues were determined by spectrophotometry. The optimum pH for complexation was 3.80.
authors.affiliation: Department of Chemistry, Seoul Woman's University, Korea.
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Han
authors.forename: K
authors.initials: K
authors.lastname: Kim
authors.forename: W B
authors.initials: WB
authors.lastname: Park
authors.forename: J K
authors.initials: JK
authors.lastname: Cho
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D002939:Ciprofloxacin / Q000737:chemistry; D015365:Enoxacin / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D008962:Models, Theoretical; D009643:Norfloxacin / Q000737:chemistry; D015242:Ofloxacin / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D000890:Anti-Infective Agents; D005290:Ferric Compounds; D015365:Enoxacin; D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin