Autosomal recessive polycystic kidney disease does not map to the second gene locus for autosomal dominant polycystic kidney disease on chromosome 4.
Linkage analysis in 19 families with autosomal recessive polycystic kidney disease (ARPKD) has shown that ARPKD is not linked to the recently assigned second gene locus for autosomal dominant polycystic kidney disease (ADPKD) on chromosome 4q (PKD2). Thus, there is strong evidence that ADPKD and ARPKD have different gene loci.
Zerres
K
K
Institut für Humangenetik, Universität Bonn, Germany.
Mücher
G
G
Rudnik-Schöneborn
S
S
D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D017044:Polycystic Kidney, Autosomal Recessive / Q000235:genetics*
D005819:Genetic Markers