title: Differential susceptibilities of enterococcal species to elfamycin antibiotics.
abstract: The elfamycins are a class of naturally occurring antibiotics not currently used in the therapy of human disease. Enterococcus faecium and closely related species (Enterococcus durans and Enterococcus hirae) are susceptible to these antibiotics, while isolates of Enterococcus faecalis and other enterococcal species are highly resistant. Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. Elfamycin susceptibility may be a useful adjunct for rapidly distinguishing E. faecalis and E. faecium in the clinical microbiology laboratory and/or as a supplementary test for use in determining the species of enterococci.
authors.affiliation: Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano, Varese, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Miele
authors.forename: B P
authors.initials: BP
authors.lastname: Goldstein
authors.forename: M
authors.initials: M
authors.lastname: Bandera
authors.forename: C
authors.initials: C
authors.lastname: Jarvis
authors.forename: A
authors.initials: A
authors.lastname: Resconi
authors.forename: R J
authors.initials: RJ
authors.lastname: Williams
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000899:Aurodox / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000145:classification / Q000187:drug effects*; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects; D011728:Pyridones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011728:Pyridones; D000899:Aurodox; C012954:efrotomycin; C008536:mocimycin