A therapeutic effect of ulinastatin on endotoxin-induced shock in dogs--comparison with methylprednisolone.
The therapeutic effect of ulinastatin (25,000 U/kg, i.v.) on endotoxin-induced shock was compared with that of methylprednisolone (30 mg/kg, i.v.) in 17 anesthetized dogs. Both of these drugs had almost the same tendency to improve the hemodynamics, arachidonate cascade metabolites and pulmonary surface activity. There was little difference between the effectiveness of ulinastatin and that of methylprednisolone. It was newly confirmed that the release of 6-keto-PGF1 alpha, thromboxane B2 and leukotriene B4, arachidonate cascade metabolites and chemical mediators associated with endotoxin-induced shock, were significantly (p < 0.01 and p < 0.05) decreased by ulinastatin in the same way as methylprednisolone. These results suggest that ulinastatin is as useful as methylprednisolone for the treatment of endotoxin-induced shock.
Okano
S
S
Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Tagawa
M
M
Urakawa
N
N
Ogawa
R
R
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D004285:Dogs; D006023:Glycoproteins / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D007975:Leukotriene B4 / Q000097:blood; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008775:Methylprednisolone / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy* / Q000503:physiopathology; D013929:Thromboxane B2 / Q000097:blood; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; D007975:Leukotriene B4; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C028665:urinastatin; D008775:Methylprednisolone