[Pancreatic endocrine F-cell tumor].
Two cases of pancreatic F-cell malignant tumors, producing only pancreatic polypeptide (PP) with clinical, biochemical and immunohistochemical features are described. No PP-associated endocrine symptoms were present. In both tumors, definitive diagnosis was immunohistochemical, and surgical treatment was carried out. Clinical evolution in the two patients was different: one of them died within the postoperative period with upper gastrointestinal bleeding by multiple duodenal ulcers, whereas the other--with lymph node metastasis at intraoperative diagnosis--is alive six years after treatment. F-cell tumors can be classified among the group of silent endocrine tumors of the pancreas. The reason for their discrepancy in the clinical behavior is unknown.
Fuertes Guiró
F
F
Universidad de Milán, Italia.
Mortara
G
G
Schiaffino
E
E
d'Urbano
C
C
D000368:Aged; D018273:Carcinoma, Islet Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010191:Pancreatic Polypeptide / Q000378:metabolism; D013156:Splenectomy
D010191:Pancreatic Polypeptide
Tumor pancreático endocrino de células F.