123I-IBZM SPECT: reconstruction methodology and results in parkinsonism and dystonia.
In 58 patients with Parkinsonism or dystonia striatal dopamine D2 receptors were investigated using 123I-iodobenzamide (123I-IBZM) single-photon emission computed tomography (SPECT). The influence of SPECT reconstruction methodology on semiquantification and the clinical value of 123I-IBZM SPECT were evaluated. Delineation of the striatal uptake and striatum/frontal cortex (ST/FC) ratios were improved by the use of compensation procedures for scatter and attenuation as well as the choice of an adequate filter. Satisfactory results were achieved using a Metz prefilter with a comparatively high order number (i.e. high cut-off and low suppression of higher frequencies via roll-off). Regarding clinical diagnoses it was not possible to differentiate between advanced idiopathic Parkinson's disease (IP) and Parkinsonism of other aetiology (OP) on the basis of 123I-IBZM SPECT. But patients with IP and favourable response to L-Dopa showed significantly higher ST/FC ratios than those with fluctuating response. In patients with dystonia ST/FC ratios were significantly higher compared to patients with IP or OP.
Berding
G
G
Abteilung für Nuklearmedizin und spezielle Biophysik, Medizinische Hochschule Hannover, FRG.
Gratz
K F
KF
Kolbe
H
H
Meyer
G J
GJ
Dengler
R
R
Knoop
B O
BO
Hundeshagen
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001549:Benzamides / Q000378:metabolism / Q000627:therapeutic use*; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D018492:Dopamine Antagonists; D004421:Dystonia / Q000000981:diagnostic imaging* / Q000378:metabolism; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D011759:Pyrrolidines / Q000378:metabolism / Q000627:therapeutic use*; D017448:Receptors, Dopamine D2 / Q000032:analysis / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D001549:Benzamides; D018492:Dopamine Antagonists; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide