Platelet-activating factor (PAF) acetylhydrolase activity, type II phospholipase A2, and cytokine levels in patients with sepsis.
Platelet activating factor acetylhydrolase (PAF-AH) activity was measured in patients with sepsis, and its relationships with various cytokines and endotoxin were evaluated. PAF-AH activity was significantly higher (p = 0.0136) in 17 patients who died than 13 patients who survived. PAF-AH activity showed significant correlations with the plasma endotoxin, TNF-alpha, and IL-8 levels. These findings suggest that PAF-AH activity reflects the severity of the pathological condition.
Endo
S
S
Critical Care & Emergency Center, Iwate Medical University, Morioka, Japan.
Inada
K
K
Yamashita
H
H
Takakuwa
T
T
Nakae
H
H
Kasai
T
T
Kikuchi
M
M
Ogawa
M
M
Uchida
K
K
Yoshida
M
M
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D016470:Bacteremia / Q000097:blood* / Q000401:mortality; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011863:Radioimmunoassay
D016207:Cytokines; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase