[Recent progress in the study of the mechanism of resistance to DNA topoisomerase inhibitors].
Altered DNA topoisomerase I and II have been shown in many cell lines resistant to topoisomerase inhibitors, showing that topoisomerases are main molecular targets of these inhibitors. In this paper, recent studies on the mechanism of resistance to DNA topoisomerase I and II inhibitors are reviewed.
Ishida
R
R
Laboratory of Biochemistry, Aichi Cancer Center Research Institute.
Andoh
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D009374:Neoplasms, Experimental / Q000473:pathology; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D002166:Camptothecin