[Influence of 11 ginsenoside monomers on action potentials of myocardiocytes].
Eleven ginsenoside monomers were added to cultured myocardiocytes of neonatal Wistar rats in a concentration of 20 micrograms.ml-1. And the action potentials (AP) were led with microelectrodes. Rb1, Rb2, Rb3, Rc, Rg1, Rg2, Re, and Rh1 inhibited AP, decreasing APA by 20%, 13%, 5%, 18%, 30%, 37%, 28%, and 23%, respectively. The potency of the most effective monomer Rg2 20 micrograms.ml-1 was similar to that of the calcium channel blocker nimodipine 1.25 micrograms.ml-1. Rd, Rf, and Ro had no significant influence on AP. The average potency of the panaxatriol saponin (PTS) monomers were greater than that of the panaxadiol saponin (PDS) monomers. The above demonstrate the reason why the calcium channel blockade action of PTS is stronger than that of PDS results from the summation of monomer drug effects.
Jiang
Y
Y
Department of Physiology, Norman Bethune University of Medical Sciences, Changchun, China.
Chen
L
L
Sun
C W
CW
Zhong
G G
GG
Qi
H
H
Ma
X Y
XY
Xu
J D
JD
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D036145:Ginsenosides; D009206:Myocardium / Q000166:cytology*; D009553:Nimodipine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*
D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; C004564:panaxadiol; D009553:Nimodipine; C004563:panaxatriol