Platelet function in acute leukemias.
Bleeding time, clot retraction, platelet factor 3 availability and platelet aggregation in response to ADP, epinephrine, collagen and ristocetin were studied in 13 cases of acute leukemia which included 5 cases of acute myeloid leukemia, 2 of chronic myeloid leukemia in blast crisis and 6 of acute lymphoblastic leukemia. More than one abnormality was seen in all the patients. Defects in bleeding time, clot retraction and platelet factor 3 availability were encountered in 43% of cases. Platelet aggregation responses to all the reagents were significantly impaired. There was, however, no consistency in the pattern of the defects.
Naresh
K N
KN
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
Sivasankaran
P
P
Veliath
A J
AJ
D001752:Blast Crisis / Q000097:blood; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D010974:Platelet Aggregation / Q000502:physiology; D010979:Platelet Function Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*