title: Contribution of scintigraphy to verify the reliability of different preparation processes for enteric coated capsules.
abstract: The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resistant in gastric fluids and soluble in intestinal zones. Results are well correlated with those previously obtained in vitro (disintegration, dissolution) and in vivo (profiles of plasmatic concentrations versus time).
authors.affiliation: Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Pharmacie, Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Catteau
authors.forename: C
authors.initials: C
authors.lastname: Barthélémy
authors.forename: M
authors.initials: M
authors.lastname: Deveaux
authors.forename: H
authors.initials: H
authors.lastname: Robert
authors.forename: F
authors.initials: F
authors.lastname: Trublin
authors.forename: X
authors.initials: X
authors.lastname: Marchandise
authors.forename: H
authors.initials: H
authors.lastname: Van Drunen
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000328:Adult; D001682:Biological Availability; D004339:Drug Compounding / Q000379:methods; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013667:Technetium
chemical_list: D007205:Indium Radioisotopes; D013608:Tablets, Enteric-Coated; D000082:Acetaminophen; D013667:Technetium; D004369:Pentetic Acid