The gene for the familial form of incontinentia pigmenti (IP2) maps to the distal part of Xq28.
Linkage data for familial incontinentia pigmenti (IP2) and 17 X chromosomal markers are reported. The linkage previously found between IP2 and the F8C locus is confirmed (Z max = 11.85 at theta = 0.028). Linkage is established with distal markers DXS1108 (Z max = 10.06 at theta = 0.00) and DXYS154 (Z = 9.07 at theta = 0.019). Multipoint analysis supports the distal localization of the IP2 gene with respect to the F8C locus.
Smahi
A
A
Unité de Recherches sur les Handicaps Génétiquesde l'Enfant, INSERM U. 12, Hôpital Necker-Enfants Malades, Paris, France.
Hyden-Granskog
C
C
Peterlin
B
B
Vabres
P
P
Heuertz
S
S
Fulchignoni-Lataud
M C
MC
Dahl
N
N
Labrune
P
P
Le Marec
B
B
Piussan
C
C
D000818:Animals; D002874:Chromosome Mapping; D005124:Eye Abnormalities / Q000235:genetics; D005260:Female; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D007184:Incontinentia Pigmenti / Q000235:genetics*; D008126:Lod Score; D008297:Male; D051379:Mice; D010375:Pedigree; D013045:Species Specificity; D014960:X Chromosome
D005819:Genetic Markers