Experimental study on the hyperplasia of juxtaglomerular cells under low-dose, long-term administration of calcium chelating agents. Similar to the morphological manifestation of Bartter's syndrome.
Bartter's syndrome is a genetic disorder which has very rarely been clinically encountered. However, it is of specific interest with respect to the hormonal layer of the kidney, including renin, angiotensin and aldosterone as well as biological alteration of the various electrolytes. The fundamental morphological manifestation of this disorder is known to be hyperplasia of juxtaglomerular cells, although, until now, no experimental studies on this condition have been reported. Demonstrated in this initial study is the remarkable hyperplasia of the juxtaglomerular cells in all terminal portions of the afferent glomerular arterioles situated near the hilum of the glomerular tuft, using a low-dose, long-term administration of calcium chelating agents. This hyperplasia reported in this paper may lead to a new procedure in the analysis of this syndrome.
Yamaguchi
H
H
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Kaku
H
H
Onodera
T A
TA
Kurokawa
R
R
Morisada
M
M
D000818:Animals; D001477:Bartter Syndrome / Q000139:chemically induced / Q000473:pathology*; D002614:Chelating Agents / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007606:Juxtaglomerular Apparatus / Q000187:drug effects* / Q000473:pathology*; D008297:Male
D002614:Chelating Agents