[A beta-casein gene fragment is located in region 1p3 of human chromosome 1].
Analysis of the nucleotide sequence of a cloned fragment of the human beta-casein gene was performed. A conserved DNA locus, present with a varying degree of degeneracy in introns of [beta]-casein genes of several species and in the intron of an oncogene of the sarc family, was revealed. It was located in region 1p31-32 by means of in situ hybridization. A clearly visible additional hybridization site was observed in region 1p36. The data obtained are discussed in the light of available information on several oncogenes that are located in region 1p3. A relation was found between this region and the occurrence of some cancers, including breast cancer.
Kost
M V
MV
Baev
A A
AA
Alimov
A A
AA
Fedorova
L I
LI
Zelenin
A V
AV
D001483:Base Sequence; D002364:Caseins / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D005091:Exons; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009857:Oncogenes
D002364:Caseins
Fragment beta-kazeinovogo gena lokalizovan v oblasti 1p3 pervoĭ khromosomy cheloveka.