title: Functional evaluation of normal and ischemic kidney by means of gadolinium-DOTA enhanced TurboFLASH MR imaging: a preliminary comparison with 99Tc-MAG3 dynamic scintigraphy.
abstract: The functional value of TurboFLASH MR imaging in the assessment of dynamic contrast enhancement and renal perfusion anomalies was evaluated in seven patients, who also underwent renal scintigraphy in baseline conditions. The basal renograms obtained from MAG-3 scintigraphy (mercapto acetyl triglycine, MAG3-S) and from Gd-DOTA-enhanced turboFLASH MRI were compared. After hydration, the protocol used consisted in breath-hold coronal turboFLASH acquisitions after IV bolus of Gd-DOTA (4 s every 20 s during 10 min) for MRI, and IV bolus of 370 MBq of 99mTc-MAG3 followed by 60 frames of 1 s and then 120 frames of 10 s for MAG3-S. Relative renal functions were computed for both methods by calculation of the integral of the uptake phase between the first and the second minute. Renograms exhibited 10 normal and 4 ischemic kidneys. There was a close correlation between the contrast enhancement of MRI and isotopic uptake in normal and ischemic kidneys. Global renograms of MRI correlated with MAG3-S (r = .82, p < .001) with similar curve shape and time to peak. Relative renal function of the right and left kidney were closely correlated in all patients (r = .98, p < .001), although there was a tendency for MR to overestimate MAG3-S evaluation in kidneys with severe basal dysfunction. Enhanced turboFLASH provides noninvasive assessment of renal perfusion in patients with renovascular disease. Accurate renograms are obtained with dynamic-enhanced MRI, but the relative renal function seems to be overestimated in low values of ischemic kidneys, and needs further comparative evaluation.
authors.affiliation: Department of Radiology, Hôpital Bichat, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Laissy
authors.forename: M
authors.initials: M
authors.lastname: Faraggi
authors.forename: R
authors.initials: R
authors.lastname: Lebtahi
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: G
authors.initials: G
authors.lastname: Brillet
authors.forename: J P
authors.initials: JP
authors.lastname: Méry
authors.forename: Y
authors.initials: Y
authors.lastname: Menu
authors.forename: D
authors.initials: D
authors.lastname: Le Guludec
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D006571:Heterocyclic Compounds; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D011446:Prospective Studies; D011866:Radioisotope Renography; D017263:Technetium Tc 99m Mertiatide
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D017263:Technetium Tc 99m Mertiatide; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate