[Clomiphene resistant PCO syndrome: IVF treatment as an alternative in failed gonadotropin treatment].
34 infertile patients with severe clomiphene-resistant polycystic ovary syndrome were treated with IVF/ET. Stimulation attempts with gonadotropins had resulted in multifollicular ovarian reactions, which did not allow standard ovulation induction using hCG due to the risk of multiple pregnancy. The resulting oocyte retrieval rates (87.4%/treatment cycle), embryo transfer rates (73.3%/oocyte retrieval) and pregnancy rates (24.2%/embryo transfer) approximately corresponded to the rates which are achieved in women with tubal failure using IVF/ET. Since strictly a maximum of 2 embryos was transferred, the occurrence of multiple pregnancies of higher degree could be avoided as opposed to standard gonadotropin therapy. The treatment so far only resulted in singleton pregnancies. The relatively high ovarian hyperstimulation rate (34.4%, primarily WHO stage I-II) could not be unequivocally lowered even by aspiration of all larger follicles.
Berg
F D
FD
I. Frauenklinik, Universität München.
Brucker
C
C
Stützle
R
R
Hinrichsen
M J
MJ
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004351:Drug Resistance; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000628:therapy*; D011247:Pregnancy; D016896:Treatment Outcome
D006062:Gonadotropins; D002996:Clomiphene
Clomiphen-resistentes PCO-Syndrom: Die IVF-Behandlung als Alternative bei Versagen der Gonadotropinbehandlung.