title: Cerebellar atrophy related to chronic exposure to toluene. Case report.
abstract: A 31-year-old woman presented slowly progressing ataxia and neurasthenic symptoms after 14-year occupational exposure to low concentration toluene vapour. Examination disclosed only cerebellar signs. Cognitive functions were normal except moderate visuo-spatial and constructive deficit. CT imaging showed severe pancerebellar atrophy without pathological signs in other brain structures. Two years after she was removed from workplace, CT imaging and ataxia showed no worsening, while visuo-constructive function improved. The authors warn against possible neurotoxic risk associated with this kind of exposure.
authors.affiliation: Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (UNICAMP), SP, Brasil.
authors.forename: B P
authors.initials: BP
authors.lastname: Damasceno
authors.forename: E M
authors.initials: EM
authors.lastname: de Capitani
mesh_terms: D000328:Adult; D001284:Atrophy / Q000134:cerebrospinal fluid / Q000139:chemically induced / Q000000981:diagnostic imaging; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D016273:Occupational Exposure / Q000009:adverse effects*; D014050:Toluene / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D014050:Toluene