[The physiological function of plasma apoA-I--the anti-viral effects of apoA-I and its fragments].
Apolipoprotein A-I (apoA-I), the major protein of plasma high density lipoproteins, was found to inhibit herpes simplex virus type I (HSV-I) induced cell fusion at physiological concentrations (mumol/L). Plasma apoA-I from three different species was used to study the anti-viral effects by microneutralization test. Marked inhibition of virus-induced cell fusion was observed when the virus or the cells were pretreated with apoA-I, suggesting that apoA-I may have a direct effect on the virus and the cells. This function may be related to the structure of apoA-I.
Hu
G
G
Institute of Basic Medical Sciences, CAMS and PUMC, Beijing.
Chen
B
B
Yan
X
X
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D016632:Apolipoprotein A-I / Q000502:physiology*; D002459:Cell Fusion / Q000187:drug effects; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000254:growth & development; D010446:Peptide Fragments / Q000502:physiology; D014709:Vero Cells
D000998:Antiviral Agents; D016632:Apolipoprotein A-I; D010446:Peptide Fragments