[Favorable response to vinblastine in an idiopathic case of Evans Syndrome].
Evan's Syndrome (ES) may develop in isolation or associated to other autoimmune diseases, solid tumors and lymphoproliferative syndromes. This type of processes can be refractory to the usual medication, that is, to corticoids and splenectomy. High doses of Immunoglobulins (polyvalent IgG) and immunosuppressive drugs are therapeutical alternatives that have been used with different results. We present a case of idiopathic ES refractory to high doses of corticoids and IgG, showing complete remission after the administration of two infusions of vinblastin. We believe that vinblastin is a very useful therapeutical alternative in the cases of ES refractory to the usual treatment.
Guerrero Becerra
M P
MP
Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid.
Kessler Saiz
P
P
Ortiz Conde
M C
MC
Fernández Miranda
C
C
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D012074:Remission Induction; D013577:Syndrome; D014747:Vinblastine / Q000627:therapeutic use*
D014747:Vinblastine
Respuesta favorable a vinblastina en un caso idiopático de Síndrome de Evans.