Azelastine inhibits acute allergic dyspnea in a conscious guinea pig asthma model.
A simple, noninvasive, bias-flow ventilated wholebody plethysmographic technique and noninvasive pulmonary analyzer (Buxco dyspnea monitor) were used to quantitate allergic dyspnea in chronically sensitized freely moving guinea pigs. In this study, the effect of azelastine on aeroallergen-induced dyspnea in allergic guinea pigs was investigated. Aeroallergen challenge produced severe dyspnea which was characterized by a 390% increase in the amplitude of pseudo flow signal, a 93% increase in box pressure (delta P) and a 68% decline in relaxation time; these changes signify a tremendous increase in the effort of breathing. The oral administration of azelastine (1 mg/kg) two hours before aeroallergen provocation significantly inhibited allergic dyspnea in this acute allergic asthma model. This technique permits quantitative measurement of the severity of the airway allergic responses in freely moving guinea pigs.
Chand
N
N
Wallace Laboratories, Division of Carter-Wallace, Inc., New Jersey 08512.
Diamantis
W
W
Nolan
K
K
Pillar
J
J
Sofia
R D
RD
D000336:Aerosols; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000517:prevention & control*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004417:Dyspnea / Q000276:immunology / Q000517:prevention & control*; D006168:Guinea Pigs; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010793:Phthalazines / Q000008:administration & dosage / Q000627:therapeutic use*; D010991:Plethysmography
D000336:Aerosols; D000485:Allergens; D001993:Bronchodilator Agents; D010793:Phthalazines; D010047:Ovalbumin; C020976:azelastine