title: Sex hormone levels in postmenopausal women with advanced metastatic breast cancer treated with CGS 169 49A.
abstract: 30 postmenopausal patients with metastatic breast cancer were treated with three different doses of fadrozole hydrochloride (CGS 169 49A), a non-steroidal competitive aromatase inhibitor. The effect of 0.5, 1 and 2 mg given twice daily upon the levels of oestrogens, their androgen precursors and upon the concentration of sex hormone binding globulin (SHBG) was investigated after 1 and 3 months and then every 3 months until progression of disease. A significant reduction in the serum concentration of oestrone (P < 0.0001) was obtained at all doses. Also, the serum concentration of oestrone sulphate was significantly reduced (P < 0.0001). However, after 1 month, the concentration was significantly different from pretreatment levels (P < 0.01) only at the 4 mg daily dose. A decline was also observed in the concentration of SHBG (P < 0.05), with a concomitant elevation of the percentage non-SHBG-bound oestradiol. The androgens, testosterone and dehydroepiandrosterone sulphate, were unaltered during treatment, while androstendione was significantly elevated at the 2 mg daily dose (P < 0.001).
authors.affiliation: Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Svenstrup
authors.forename: J
authors.initials: J
authors.lastname: Herrstedt
authors.forename: N
authors.initials: N
authors.lastname: Brünner
authors.forename: P
authors.initials: P
authors.lastname: Bennett
authors.forename: H
authors.initials: H
authors.lastname: Wachmann
authors.forename: P
authors.initials: P
authors.lastname: Dombernowsky
mesh_terms: D000368:Aged; D000728:Androgens / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000097:blood*; D017316:Fadrozole / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D017698:Postmenopause / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000728:Androgens; D004967:Estrogens; D012738:Sex Hormone-Binding Globulin; D017316:Fadrozole