title: The effect of mouse mammary tumor virus receptor activation on mammary epithelial cell sensitivity toward prolactin.
abstract: Mammary epithelial cells infected with the mouse mammary tumor virus (MMTV) require less than one-half the concentration of prolactin to elicit alpha-lactalbumin production than uninfected tissue (EC50 = 89 +/- 10 ng/ml vs. 206 ng/ml, respectively). Furthermore, stimulating antibodies to the cellular receptor for MMTV halved the prolactin requirement of MMTV-tissue, while MMTV antibodies that sequestered secreted MMTV increased the prolactin requirement in MMTV+ tissue. These data suggest that the effect of MMTV on mammary epithelial sensitivity toward prolactin is being mediated by its interaction with a cell surface receptor.
authors.affiliation: Department of Biological Sciences, University of South Carolina, Columbia 29208.
authors.forename: F F
authors.initials: FF
authors.lastname: Bolander
mesh_terms: D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000821:virology; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology / Q000821:virology*; D008324:Mammary Tumor Virus, Mouse / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D011388:Prolactin / Q000502:physiology*; D011991:Receptors, Virus / Q000502:physiology*; D012756:Sheep; D013552:Swine
chemical_list: D011991:Receptors, Virus; D011388:Prolactin