Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system.
An attempt was made to isolate the active component of Eriobotrya japonica, which inhibits aflatoxin B1-induced mutagenicity in the Salmonella assay system. The number of revertants per plate was significantly decreased when a MeOH extract of Eriobotrya japonica was added to the assay system using Salmonella typhimurium TA100 or TA98. Furthermore, we examined the effect of each fraction purified from the MeOH extract, and an EtOAc fraction was found to be the most effective. Ursolic acid isolated from the EtOAc fraction markedly and significantly decreased the numbers of Salmonella typhimurium TA100 revertants per plate, thus showing antimutagenic activity.
Young
H S
HS
Department of Pharmacy, Pusan National University, Korea.
Chung
H Y
HY
Lee
C K
CK
Park
K Y
KY
Yokozawa
T
T
Oura
H
H
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects; D014315:Triterpenes / Q000494:pharmacology*; D000097245:Ursolic Acid
D016604:Aflatoxin B1; D016587:Antimutagenic Agents; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid