[Cardiac complications of halofantrine: continuous electrocardiographic study (holter) in 20 patients].
Three cases of long QT-interval due to halofantrine were documented in 1992 in France. Two of them had a congenital long QT-interval (Romano-Ward syndrome). We performed a prospective study of cardiac monitoring in 20 patients taking halofantrine. Minimal ECG changes were noted with lengthening of the QT-interval. Systematic ECG is necessary before giving halofantrine.
Monlun
E
E
Clinique médicale propédeutique, médecine interne et maladies tropicales, hôpital Saint André, CHU Bordeaux, France.
Le Metayer
P
P
Receveur
M C
MC
Bouabdallah
K
K
Neau
D
D
Longy-Boursier
M
M
Le Bras
M
M
D000962:Antimalarials / Q000009:adverse effects*; D015716:Electrocardiography, Ambulatory; D006331:Heart Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D010616:Phenanthrenes / Q000009:adverse effects*; D011446:Prospective Studies
D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine
Complications cardiaques de l'halofantrine: etude électrocardiographique continue (holter) chez 20 patients.