Presence of a mitochondrial DNA deletion in fetal and adult bovine cardiac tissue.
A deletion of about 5.3 kilobases has been detected in the mitochondrial DNA of bovine cardiac tissue. This deletion appears to be somatic in origin given its sporadic presence in the various heart compartments examined. Cardiac tissue derived from developmental stages including fetal, early and older adult animals harbored this mutation with increased levels (100-1000 fold) found in older adults. The deleted region of the mitochondrial genome maps to relatively the same area (deleting ATPase6, COXIII, ND2, ND4 and a portion of ND5) as the common 5 kb deletion reported in humans, but its presence in fetal tissue, as well as its decreased age dependence distinguish it relative to the reported human deletion.
Marin-Garcia
J
J
Molecular Cardiology Institute, Highland Park, NJ 08904.
Ananthakrishnan
R
R
Goldenthal
M J
MJ
D000375:Aging; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002874:Chromosome Mapping; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D005314:Embryonic and Fetal Development; D005318:Fetal Heart / Q000737:chemistry*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008969:Molecular Sequence Data; D009206:Myocardium / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D017384:Sequence Deletion / Q000502:physiology*
D004272:DNA, Mitochondrial