title: [Anaphylactic shock and low osmolarity contrast medium].
abstract: BACKGROUND
  Low osmolality contrast media are generally better tolerated than those with high osmolality. This report describes a case of severe collapse after injecting a low osmolality contrast medium.
  
  
  METHODS
  A 15 month-old girl with aortic arch abnormalities was admitted for investigation under general anesthesia. She had a history of allergy but had not previously been exposed to contrast medium. She was given ioxaglate (2 mg/kg) into an artery. The infusion immediately resulted in generalized erythema, tachycardia, hypotensive collapse and ECG abnormalities. The patient was immediately given adrenaline, vasopressive drugs, corticosteroids and plasma protein fraction, which led to a rapid recovery. The ductus arteriosus was ligated a few days later without complications despite the application of iodine to the skin and the use of anesthetic drugs.
  
  
  CONCLUSIONS
  An unpredictable adverse reaction to low osmolality contrast medium can occur. Risk factors must be identified and immediate arrangements made for resuscitation.
authors.affiliation: Service de pharmacologie clinique, hôpital Robert-Debré, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bennasr
authors.forename: S
authors.initials: S
authors.lastname: Magnier
authors.forename: M
authors.initials: M
authors.lastname: Hassan
authors.forename: E
authors.initials: E
authors.lastname: Jacqz-Aigrain
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D007485:Ioxaglic Acid / Q000009:adverse effects*; D009994:Osmolar Concentration; D012074:Remission Induction
chemical_list: D007485:Ioxaglic Acid
vernacular_title: Choc anaphylactique et produit de contraste de faible osmolarité.