title: Chondrosarcoma of bone: oncologic and functional results.
abstract: A retrospective review of 27 patients (21 males and 6 females) with chondrosarcoma of bone was performed to evaluate the oncologic and functional results. The average age of the patients was 48 years (range: 17-76). The tumor sites were pelvis in 10 cases, distal femur in 2, proximal tibia in 3, rib in 2, and other in 10. One patient with Ollier's disease had chondrosarcoma at two different sites simultaneously. Surgical stages were I A in 8 cases, I B in 8, II A in 1, and II B in 10. Two patients had no surgical treatment. Amputation was performed in 5 cases and en bloc resection in 20. An uncontaminated radical or wide surgical margin was achieved in 13 of 25 cases. Additional surgery was performed in seven cases; for deep infection in one case and for local recurrence or metastasis in six. Local recurrence developed in seven patients (26%). At follow-up, four patients had died of disease (15%), one patient had died of another cause, and two patients were alive with disease (7%). No evidence of disease was found in 20 patients (74%). The oncologic results of limb salvage and amputation in chondrosarcoma of the limbs were good, although there was one failure of limb salvage, caused by infection. Due to surgical inaccessibility, results of the management of chondrosarcoma of the pelvis were poor. The average functional evaluation of 16 patients (average follow-up: 104 months) was 75% (range: 30-100). The Musculoskeletal Tumor Society ratings were excellent in four cases, good in seven, fair in four, and poor in one.
authors.affiliation: Department of Orthopaedics, University Hospital, Nijmegen, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: van Loon
authors.forename: R P
authors.initials: RP
authors.lastname: Veth
authors.forename: M
authors.initials: M
authors.lastname: Pruszczynski
authors.forename: T
authors.initials: T
authors.lastname: Wobbes
authors.forename: J A
authors.initials: JA
authors.lastname: Lemmens
authors.forename: J
authors.initials: J
authors.lastname: van Horn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000175:diagnosis / Q000601:surgery*; D002813:Chondrosarcoma / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome