title: MR imaging field strength: prospective evaluation of the diagnostic accuracy of MR for diagnosis of multiple sclerosis at 0.5 and 1.5 T.
abstract: OBJECTIVE
  To compare the diagnostic efficacy of middle-field-strength and high-field-strength magnetic resonance (MR) imaging in diagnosis of multiple sclerosis.
  
  
  METHODS
  One hundred thirty-two patients with suspected multiple sclerosis underwent MR imaging at 0.5 and 1.5 T. Imaging parameters were identical except for band width optimization at middle field strength. Images were interpreted by radiologists expert in MR imaging who were blinded to diagnosis and field strength. The diagnosis of multiple sclerosis was made by experienced neurologists, and indeterminate cases and patients without clinical evidence of multiple sclerosis were followed up for 6 months to 1 year.
  
  
  RESULTS
  There was no difference in accuracy, sensitivity, or specificity between scanners in the diagnosis of multiple sclerosis or white matter disease. Equal numbers of lesions were detected at both field strengths in all parts of the brain. Image quality was always good or adequate at middle field strength.
  
  
  CONCLUSIONS
  Higher field strength does not confer higher accuracy in the diagnosis of multiple sclerosis with current-generation MR imagers.
authors.affiliation: Department of Radiology, University Hospital, London, Ont, Canada.
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: A D
authors.initials: AD
authors.lastname: Vellet
authors.forename: M
authors.initials: M
authors.lastname: Eliasziw
authors.forename: L
authors.initials: L
authors.lastname: Vidito
authors.forename: G C
authors.initials: GC
authors.lastname: Ebers
authors.forename: G P
authors.initials: GP
authors.lastname: Rice
authors.forename: L
authors.initials: L
authors.lastname: Hewett
authors.forename: S
authors.initials: S
authors.lastname: Dunlavy
mesh_terms: D004311:Double-Blind Method; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity