Determination of papaverine and cocaine by use of a precipitation system coupled on-line to an atomic absorption spectrometer.
A continuous-precipitation flame-atomization atomic absorption spectrometric method for the determination of papaverine and cocaine hydrochlorides is proposed. The method is based on the precipitation of reineckates by injection of Reinecke's salt into a carrier containing the alkaloids and their subsequent retention on a stainless steel filter. In this way, papaverine and cocaine hydrochlorides can be determine over the ranges 5-85 and 50-850 micrograms ml-1 with a relative standard deviation of 1.3 and 3.2%, respectively, and a sampling frequency of 150 h-1. The proposed method is more sensitive and selective for papaverine than it is for cocaine and can be applied to the determination of papaverine HCl in pharmaceutical preparations.
Eisman
M
M
Department of Analytical Chemistry, Faculty of Sciences, University of Córdoba, Spain.
Gallego
M
M
Varcárcel
M
M
D011232:Chemical Precipitation; D003042:Cocaine / Q000032:analysis* / Q000737:chemistry; D008962:Models, Theoretical; D010208:Papaverine / Q000032:analysis* / Q000737:chemistry; D013054:Spectrophotometry, Atomic / Q000379:methods
D010208:Papaverine; D003042:Cocaine