[The distribution of antibodies to the herpes simplex virus in different types of raw material used for producing immunoglobulin preparations].
The distribution of antibodies to herpes simplex virus (HSV) in different kinds of biological raw materials has been studied with the use of the enzyme-linked immunosorbent assay. The study has revealed that the content of herpes-specific antibodies in pooled placental and donor blood sera and in the preparations of commercial normal immunoglobulins is sufficiently uniform, and 7-10% of these sera and preparations have elevated titers of antibodies to HSV. Blood sera of individual donors are characterized by greater differences in the content of herpes-specific antibodies. About 10% of such sera have significantly greater titers of antibodies to HSV. From selected blood sera of individual donors with initially high titers of antibodies to HSV the preparation of antiherpes immunoglobulin has been obtained; the specific activity of this preparation is 4- to 6-fold higher than that of preparations of commercial normal immunoglobulins.
Kostrova
O M
OM
Ponomareva
A M
AM
Filippova
L M
LM
Aleshkin
V A
VA
D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D001782:Blood Donors; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000302:isolation & purification*; D018139:Simplexvirus / Q000276:immunology*
D000914:Antibodies, Viral; D007136:Immunoglobulins
Izuchenie raspredeleniia antitel k virus prostogo gerpesa v razlichnykh vidakh syr'ia, ispol'zuemogo dlia polucheniia preparatov immunoglobulinov.