title: Peroxisome proliferation of hepatocytes in rats by a microbial degradation product of cholic acid, 4-(decahydro-6-methyl-3-oxocyclopenta(f)quinoline-7-yl)valeric acid.
abstract: Three-week oral administration of 4-(decahydro-6-methyl-3-oxo-cyclopenta(f)quinoline-7-yl)valeric acid (32-1328) in the diet supplemented at concentrations of 0.1% or 0.3% was associated with hepatomegaly and hypotriglyceridemia in male F344 rats. Electron microscopic examination of the liver revealed a remarkable increase of peroxisomes in hepatocytes both in number and size. Biochemically, there were increased activities of peroxisomal marker enzymes including the heat-labile enoyl-CoA hydratase and catalase while the mitochondrial enoyl-CoA hydratase activity was unchanged after feeding of 32-1328. These findings indicate that 32-1328 can exert peroxisome-proliferating activity to rat liver in a manner similar to typical peroxisome proliferators such as clofibrate or di(2-ethylhexyl)phthalate.
authors.affiliation: Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Toyoda
authors.forename: T
authors.initials: T
authors.lastname: Imazawa
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Okamiya
authors.forename: Y
authors.initials: Y
authors.lastname: Kurokawa
authors.forename: J
authors.initials: J
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Mogami-Nishimaki
authors.forename: S
authors.initials: S
authors.lastname: Hayakawa
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D008830:Microbodies / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D014631:Valerates / Q000494:pharmacology*
chemical_list: D011804:Quinolines; D014631:Valerates; C083646:4-(decahydromethyl-3-oxo-1H-cyclopentaquinolinyl)valeric acid