A reduction in serum glucocorticoids provokes experimental allergic encephalomyelitis: implications for treatment of inflammatory brain disease.
Glucocorticoid (GCC) therapy usually inhibits inflammatory diseases, but certain regimens can trigger relapses. Clinical use of steroids is not uniform and in some instances may be dangerous. In the present study, GCCs modified the course of experimental allergic encephalomyelitis (EAE) in Lewis rats, a model of inflammatory CNS disease. Continuous treatment with dexamethasone (DEX) completely blocked EAE. RU 486, a GCC antagonist, counteracted the effects of endogenous GCCs and worsened EAE. Sudden withdrawal of DEX also caused severe clinical and histologic exacerbations at a time when paired saline-treated animals had completely recovered. In rats that had complete clinical recovery from EAE, and would not have relapsed without this acute steroid deficit, a short pulse of DEX was followed by severe exacerbations. In contrast, a slow steroid taper prevented exacerbations. Abrupt discontinuation of GCCs provokes inflammatory brain disease.
Reder
A T
AT
Department of Neurology, University of Chicago, IL 60637.
Thapar
M
M
Jensen
M A
MA
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005938:Glucocorticoids / Q000097:blood*; D015735:Mifepristone / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000098:blood supply / Q000187:drug effects / Q000473:pathology*; D013997:Time Factors
D005938:Glucocorticoids; D015735:Mifepristone; D003907:Dexamethasone