title: The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells.
abstract: An enteropathogenic Escherichia coli mutant carrying an internal deletion in the eaeB gene (UMD864) was unable to activate epithelial cell signals, including tyrosine phosphorylation, cytoskeletal rearrangements, and the release of inositol phosphates, indicating that the eaeB locus encodes a product that is involved in stimulating signals in epithelial cells.
authors.affiliation: Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Foubister
authors.forename: I
authors.initials: I
authors.lastname: Rosenshine
authors.forename: M S
authors.initials: MS
authors.lastname: Donnenberg
authors.forename: B B
authors.initials: BB
authors.lastname: Finlay
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D004848:Epithelium / Q000382:microbiology / Q000648:ultrastructure; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity* / Q000648:ultrastructure; D029968:Escherichia coli Proteins; D017353:Gene Deletion; D005798:Genes, Bacterial / Q000235:genetics*; D006367:HeLa Cells / Q000382:microbiology / Q000648:ultrastructure; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D015398:Signal Transduction; D014774:Virulence / Q000235:genetics
chemical_list: D001425:Bacterial Outer Membrane Proteins; C087863:EaeB protein, E coli; D029968:Escherichia coli Proteins; D007295:Inositol Phosphates