Viral hepatitis and hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is one of the more common internal malignancies worldwide and is responsible for over 1 million deaths annually. The causative relationship between chronic hepatitis B and HCC is now beyond doubt, and it is likely that the attributable risk of HCC due to hepatitis C virus (HCV) infection is similar to or greater than that for hepatitis B in some countries. The prospects for preventing HCC with the use of a vaccine against HBV appear excellent. Until a vaccine against HCV becomes available, prevention of HCV-related HCC is predominantly dependent on a reduction in transfusion-associated disease.
Sallie
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Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Di Bisceglie
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AM
D000465:Algorithms; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy; D003131:Combined Modality Therapy; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology; D003699:Hepatitis D / Q000150:complications / Q000453:epidemiology; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy; D008403:Mass Screening; D015995:Prevalence; D012307:Risk Factors