(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.
Loss of heterozygosity in human chromosome 7q was studied to determine the location of a putative tumor suppressor gene. Twenty-six of 31 cases studied presented loss of heterozygosity at one or more loci on chromosome 7q. Eighty-three percent loss of heterozygosity (in 11 informative cases) was detected by using the (C-A)n microsatellite repeat marker D7S522 at 7q31.1-7q31.2. These results suggest that a tumor suppressor gene relevant to the development of breast cancer is present in the 7q31.1-7q31.2 region, confirming our previous evidence for a tumor suppressor gene in this chromosome and frequent deletions of the long arm in human primary breast cancers.
Zenklusen
J C
JC
University of Texas M. D. Anderson Cancer Center Science Park-Research Division, Smithville 78957.
Bièche
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I
Lidereau
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Conti
C J
CJ
D000483:Alleles; D001943:Breast Neoplasms / Q000097:blood / Q000235:genetics*; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D004247:DNA / Q000097:blood / Q000302:isolation & purification; D004273:DNA, Neoplasm / Q000302:isolation & purification; D004276:DNA, Satellite / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping; D017384:Sequence Deletion
D004273:DNA, Neoplasm; D004276:DNA, Satellite; D004247:DNA