title: 1,4,5-trialkyl imidazole system anti-inflammatory properties of new substituted derivatives.
abstract: In an investigation of the anti-inflammatory properties of five-membered ring nitrogen-containing heterocyclic compounds, two series of derivatives of imidazole were prepared by altering the sites of substitution and by joining aliphatic chains to the nitrogen atom in the 1 position of the imidazole ring. Some of them were more potent inhibitors of carrageenan-induced edema than indomethacin. An electron spin resonance study indicated that these compounds possess anti-radical activity.
authors.affiliation: Départment of Organic and Therapeutic Chemistry, Faculty of Pharmacy, Université de Limoges, France.
authors.forename: J
authors.initials: J
authors.lastname: Fatimi
authors.forename: J F
authors.initials: JF
authors.lastname: Lagorce
authors.forename: J L
authors.initials: JL
authors.lastname: Duroux
authors.forename: M L
authors.initials: ML
authors.lastname: Chabernaud
authors.forename: J
authors.initials: J
authors.lastname: Buxeraud
authors.forename: C
authors.initials: C
authors.lastname: Raby
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D002417:Cattle; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D016166:Free Radical Scavengers; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D007093:Imidazoles; D002351:Carrageenan