Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium.
Alternariol and alternariol methyl ether were tested in the Ames Salmonella typhimurium assay, and both were shown, with and without metabolic activation, to be nonmutagenic to strains TA98 and TA100. The finding of other investigators that alternariol methyl ether is weakly mutagenic to TA98 without metabolic activation could have resulted from the presence of a small amount of one of the highly mutagenic altertoxins in the alternariol methyl ether originally tested.
Davis
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Division of Molecular Biological Research and Evaluation, U.S. Food and Drug Administration, Washington, D.C. 20204.
Stack
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D000818:Animals; D001711:Biotransformation; D066298:In Vitro Techniques; D007783:Lactones / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens / Q000493:pharmacokinetics / Q000494:pharmacology*; D009183:Mycotoxins / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D007783:Lactones; D009153:Mutagens; D009183:Mycotoxins; C005197:alternariol; C018206:alternariol monomethyl ether