title: [Subcutaneous phaeohyphomycose due to Exophiala jeanselmir. Report of 3 cases in patients with a kidney transplant].
abstract: We report three cases of subcutaneous phaeohyphomycosis due to Exophiala jeanselmei (Langeron) McGinnis et Padhye 1977, in kidney transplant patients. Exophiala jeanselmei is a dematious fungus having also ability to rarely procedure eumycetoma (black grains). According to KWON-CHUNG & BENNETT (1992) such fungus is antigenically very heterogeneous, since so far three serotypes have been identified; each serotype including subgroups. Subcutaneous phaeohyphomycosis is becoming more and more frequent in kidney transplant patients submitted to an immunosuppressive treatment. As Exophiala jeanselmei has already been isolated from the environment it becomes difficult to explain the pathogenicity of these cases by a reactivation of quiescent processes. The authors suggest an occasional fungistatic action of cyclosporine A upon Exophiala jeanselmei.
authors.affiliation: Unidade de Transplante Renal do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brasil.
authors.forename: E
authors.initials: E
authors.lastname: Sabbaga
authors.forename: L M
authors.initials: LM
authors.lastname: Tedesco-Marchesi
authors.forename: C da S
authors.initials: Cda S
authors.lastname: Lacaz
authors.forename: L C
authors.initials: LC
authors.lastname: Cucé
authors.forename: A
authors.initials: A
authors.lastname: Salebian
authors.forename: E M
authors.initials: EM
authors.lastname: Heins-Vaccari
authors.forename: M N
authors.initials: MN
authors.lastname: Sotto
authors.forename: N Y
authors.initials: NY
authors.lastname: Valente
authors.forename: E
authors.initials: E
authors.lastname: Porto
authors.forename: M
authors.initials: M
authors.lastname: Levy Neto
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D003881:Dermatomycoses / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D005093:Exophiala / Q000302:isolation & purification* / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000382:microbiology*
chemical_list: D016572:Cyclosporine
vernacular_title: Feo-hifomicose subcutânea por Exophiala jeanselmei. Registro de três casos em transplantados renais.