title: Fetal hypothyroidism as a complication of amiodarone treatment for persistent fetal supraventricular tachycardia.
abstract: We present a case of persistent fetal supraventricular tachycardia where transplacental and direct fetal treatment with amiodarone caused an iatrogenic hypothyroidism. This condition was successfully managed with the intra-amniotic instillation of 250 micrograms of L-thyroxine weekly, for 3 weeks. A male infant was delivered at 32 weeks by Caesarean section. The neonatal electrocardiogram showed Wolf-Parkinson-White (WPW) syndrome, which was controlled by digoxin alone. Thyroid function normalized quickly and the baby is developing normally.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit Brussel, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: De Catte
authors.forename: D
authors.initials: D
authors.lastname: De Wolf
authors.forename: J
authors.initials: J
authors.lastname: Smitz
authors.forename: A
authors.initials: A
authors.lastname: Bougatef
authors.forename: J
authors.initials: J
authors.lastname: De Schepper
authors.forename: W
authors.initials: W
authors.lastname: Foulon
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D004077:Digoxin / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000209:etiology*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy
chemical_list: D004077:Digoxin; D000638:Amiodarone; D013974:Thyroxine