title: The influence of maternal separation on humoral and cellular immunity in farmed deer.
abstract: The effect of maternal separation on in vivo and in vitro immune parameters was studied in young hybrid deer. Groups of fawns separated from their mothers either 2 days prior to or 7 days post immunization with keyhole limpet hemocyanin were compared with a control group of immunized, unseparated fawns. Animals separated prior to antigenic challenge had significantly higher concentrations of antigen-specific IgG in their serum than control animals. There was no influence on the humoral immune response in animals separated following immunization. In contrast, Con A transformations were transiently depressed in separated animals compared to the control group. The time separation was imposed relative to challenge and therefore influenced the subsequent immune response.
authors.affiliation: Department of Pathology, Cambridge University, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Hibma
authors.forename: J F
authors.initials: JF
authors.lastname: Griffin
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000276:immunology / Q000523:psychology*; D000833:Animals, Suckling / Q000276:immunology / Q000523:psychology; D000917:Antibody Formation; D003208:Concanavalin A / Q000494:pharmacology; D003670:Deer / Q000276:immunology / Q000523:psychology*; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008426:Maternal Deprivation
chemical_list: D007074:Immunoglobulin G; D003208:Concanavalin A