Effect of sodium deoxycholate on the dissolution and absorption of copper-indomethacin and zinc-indomethacin.
The effects of sodium deoxycholate on the dissolution of indomethacin metal complexes were investigated. At pH 7.2, the dissolution of copper-indomethacin was very slow, while the dissolution of zinc-indomethacin was higher but less than that of indomethacin. In the presence of 5 mg of sodium deoxycholate, the dissolution of copper-indomethacin and zinc-indomethacin was significantly enhanced. The absorption of zinc-indomethacin in the rat jejunum was low, but that of copper-indomethacin was high, as compared to indomethacin. The addition of 0.2% sodium deoxycholate significantly enhanced the jejunal absorption of zinc-indomethacin in the rat, but did not increase the absorption of copper-indomethacin. Results indicated that the in vivo absorption behavior of zinc-indomethacin was predictable by in vitro dissolution, but such correlation was not applicable to copper-indomethacin. The absorption of copper-indomethacin was similar to that of indomethacin, in spite of its poor dissolution.
Lee
S Y
SY
Department of Pharmacy and Administrative Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY 11439.
Belmonte
A A
AA
D000818:Animals; D003300:Copper / Q000737:chemistry* / Q000493:pharmacokinetics*; D003840:Deoxycholic Acid / Q000737:chemistry* / Q000494:pharmacology*; D007213:Indomethacin / Q000737:chemistry* / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D015032:Zinc / Q000737:chemistry* / Q000493:pharmacokinetics*
D003840:Deoxycholic Acid; D003300:Copper; D015032:Zinc; D007213:Indomethacin