A fulminant case of neuroleptic malignant syndrome.
We report a fulminant case of Neuroleptic Malignant Syndrome in a 31-year-old male schizophrenic on haloperidol, thioridazine, benzhexol and flurazepam who presented with rigidity, fever, stupor and autonomic instability. He succumbed rapidly over 6 days to rhabdomyolysis, acute renal failure, status epilepticus and disseminated intravascular coagulopathy despite treatment with dantrolene and bromocriptine at the outset.
Teo
S K
SK
Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore.
Lam
K N
KN
Chew
W L
WL
D000328:Adult; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000150:complications / Q000175:diagnosis*; D009460:Neurologic Examination / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy*; D013881:Thioridazine / Q000008:administration & dosage / Q000009:adverse effects*
D006220:Haloperidol; D013881:Thioridazine