Different lipid contents between aldosterone-producing and nonhyperfunctioning adrenocortical adenomas: in vivo measurement using chemical-shift magnetic resonance imaging.
Lipid contents in the 11 aldosterone-producing and 24 nonhyperfunctioning adrenocortical adenomas and 8 pheochromocytomas were assessed in vivo by using chemical-shift fast low-angle shot magnetic resonance imaging. T2 relaxation times were measured by using a spin echo sequence. The relative lipid contents of pheochromocytomas were significantly less than adrenocortical adenomas. The relative lipid contents of aldosterone-producing adenomas were significantly less than nonhyperfunctioning adenomas. The longer T2 relaxation times of aldosterone-producing adenomas may also represent less lipid contents compared with nonhyperfunctioning adenomas. These results strongly support the suggestion that there is a very close relationship between accumulated lipid droplets and functional aspects in the adrenocortical cells. Chemical-shift magnetic resonance imaging may be a useful method for the indirect analysis of the function of adrenocortical adenomas in vivo.
Tsushima
Y
Y
Department of Diagnostic Radiology, Gunma University Hospital, Japan.
D000236:Adenoma / Q000378:metabolism*; D000306:Adrenal Cortex Neoplasms / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism
D000450:Aldosterone