title: Rearranged p53 gene with loss of normal allele in a low-grade nonrecurrent glioma.
abstract: We are studying the p53 gene profile in primary glial tumors by seeking alterations in the hybridization pattern of the tumor DNA probed with a p53 gene probe. This report documents a rearranged p53 gene with loss of the normal allele in a low-grade mixed glioma which has not recurred during 4-year follow-up. The tumor had a low 5-bromodeoxyuridine (BrdU)-labeling index and low AgNOR count. The p53 protein was not detected on immunochemical staining. To our knowledge, this is the first report of an altered p53 gene in a low-grade nonrecurrent glial tumor and highlights the presence of further checks and balances on the control of cell proliferation and other malignancy-associated phenotypes, even in an already-established tumor.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi.
authors.forename: M
authors.initials: M
authors.lastname: Ghosh
authors.forename: A
authors.initials: A
authors.lastname: Dinda
authors.forename: P
authors.initials: P
authors.lastname: Chattopadhyay
authors.forename: C
authors.initials: C
authors.lastname: Sarkar
authors.forename: S
authors.initials: S
authors.lastname: Bhatia
authors.forename: S
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000483:Alleles; D001932:Brain Neoplasms / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged