Nerve growth factor: pathophysiological and therapeutic implications.
Neurotrophic factors are target-derived proteins capable of affecting survival, target innervation, and/or function of neuronal cell populations. Nerve growth factor (NGF) is the best-studied member of the genetic family called neurotrophins. There is however little knowledge whether other neurotrophins play a pathophysiological role in diseases of the peripheral and central nervous system. An increasing number of animal studies suggest that NGF plays a role in (a) peripheral nerve regeneration, (b) diabetic neuropathy, and (c) age-related neurodegenerative processes within the brain.
Hellweg
R
R
Department of Psychiatry, Free University of Berlin, Germany.
Raivich
G
G
D000818:Animals; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009422:Nervous System Diseases / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
D009414:Nerve Growth Factors