[Relationship between irradiation and appearance of brain tumors in rats].
Sprague-Dawley rats were exposed to Co 60 irradiation (3 Gy) at different ages. Rats were distributed among sham-control (618 males and 120 females) and exposed groups: foetus (66 males and 65 females), 3 month-old (304 males), and 9 month-old (120 males and 60 females). The incidence of brain tumours was 5.3% in male control rats and nil in female control rats. Brain tumour incidence decreased in 9 month-old rats (3.3%), and increased from 6.6% in 3 month-old rats to 15.2% in male foetuses and 12.3% in female foetuses. Age at incidence of brain tumours decreased in irradiatiated animals. Astrocytomas were the more susceptible type of brain tumours to radiocarcinogenesis.
Morin
M
M
CEA, CENFAR/DSV/DPTE, Fontenay-aux-Roses, France.
Allin
F
F
Altmeyer
S
S
Masse
R
R
D000367:Age Factors; D000818:Animals; D001254:Astrocytoma / Q000453:epidemiology* / Q000209:etiology*; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D008297:Male; D008577:Meningeal Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D008579:Meningioma / Q000453:epidemiology* / Q000209:etiology*; D009374:Neoplasms, Experimental; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
Relations entre l'irradiation et l'apparition des tumeurs cérbrales chez le rat.