Can superantigens trigger sudden infant death?
A majority of sudden infant death syndrome (SIDS) victims have respiratory or gastrointestinal infections prior to death. This has led to an investigation of the role of pathogenic bacteria and the potentially lethal toxins they produce as triggers for sudden infant death. A small group of bacteria have been consistently identified in SIDS victims as compared to controls, and remarkably, three of these produce superantigenic toxins. Superantigens exert a powerful effect on the immune system, stimulating T-cells, which subsequently induces the formation of large amounts of cytokines. Generation of an overwhelming inflammatory response may lead to death by shock, or other, as yet unrecognized effects of the toxin on the respiratory or cardiac systems. A SIDS/superantigen model is proposed which may explain many of the pathological characteristics of SIDS and establish quantifiable markers for SIDS.
Lindsay
J A
JA
Department of Food Science and Human Nutrition, University of Florida, Gainesville 32611.
Johnson
H M
HM
Wallace
F M
FM
Soos
J M
JM
D001424:Bacterial Infections / Q000150:complications; D001427:Bacterial Toxins / Q000009:adverse effects; D005767:Gastrointestinal Diseases / Q000150:complications; D006801:Humans; D007223:Infant; D008954:Models, Biological; D012141:Respiratory Tract Infections / Q000150:complications; D013398:Sudden Infant Death / Q000209:etiology*; D018089:Superantigens / Q000009:adverse effects*
D001427:Bacterial Toxins; D018089:Superantigens