title: [The stereoselectivity of chrono-pharmacokinetic parameters of hydratropic acid in rats].
abstract: The stereoselective chrono-pharmacokinetic parameters of hydratropic acid in rats were studied. The results showed that under standard light-dark cycle pharmacokinetic parameters of T1/2 alpha and CL are stereoselective and under reverse light-dark cycle, parameters T1/2 beta, AUC, CL, Vc and MRT were shown to be stereoselective. To compare the corresponding parameters of the two different light-dark cycles using t-test, no differences were found in most of them.
authors.affiliation: Institute of Medical and Pharmaceutical Science, Tianjin.
authors.forename: Y S
authors.initials: YS
authors.lastname: He
authors.forename: H L
authors.initials: HL
authors.lastname: Lu
authors.forename: D Y
authors.initials: DY
authors.lastname: Wang
authors.forename: S X
authors.initials: SX
authors.lastname: He
mesh_terms: D000204:Activity Cycles; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D008297:Male; D010666:Phenylpropionates / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
chemical_list: D010666:Phenylpropionates; C013025:hydratropic acid