title: Relationship between in vitro metabolism of pyrrolizidine alkaloids and extrahepatic toxicity in vivo.
authors.affiliation: Department of Pharmacology, College of Medicine, University of Arizona, Tucson 85724.
authors.forename: R J
authors.initials: RJ
authors.lastname: Huxtable
authors.forename: S L
authors.initials: SL
authors.lastname: Wild
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D010947:Plants, Toxic / Q000737:chemistry; D011763:Pyrrolizidine Alkaloids / Q000378:metabolism* / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011763:Pyrrolizidine Alkaloids; D010634:Phenobarbital