title: [Drug administration via the endobronchial route. Possibilities of drug administration in emergency medicine].
abstract: For cardiopulmonary resuscitation, the endobronchial route represents a good means of administering drugs with a systemic effect, such as adrenaline and atropine, even without a venous line. Via this route, however, higher doses are needed (2.5 times as much as those normally given intravenously). In order to produce a larger surface area within the bronchio-alveolar space and thus speed up absorption, the drugs are diluted in 5-10 ml solvent (isotonic saline solution or distilled water). For endobronchial administration of a drug, various techniques are employed, for example, simply injecting it into the upper end of the (endotracheal) tube, puncture of the tube the use of an application probe introduced into the endobronchial tube, aspiration or venacaval catheter, or the EDGAR tube with an injection needle incorporated within the tube wall. After injection, the diluted medication is distributed into the tiny branches of the bronchial tree by repeated hyperventilation. Despite the need for an adequate alternative to the venous route in the field of cardiopulmonary resuscitation, we still have very few reliable facts about the endobronchial application technique.
authors.forename: L
authors.initials: L
authors.lastname: Mielke
authors.forename: E
authors.initials: E
authors.lastname: Entholzner
authors.forename: S
authors.initials: S
authors.lastname: Hargasser
authors.forename: R
authors.initials: R
authors.lastname: Hipp
mesh_terms: D000280:Administration, Inhalation; D001285:Atropine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016887:Cardiopulmonary Resuscitation; D003975:Diazepam / Q000008:administration & dosage / Q000493:pharmacokinetics; D004630:Emergencies; D004837:Epinephrine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics; D009270:Naloxone / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D009270:Naloxone; D001285:Atropine; D008012:Lidocaine; D003975:Diazepam; D004837:Epinephrine
vernacular_title: Medikamentengabe über den endobronchialen Zugang. Möglichkeiten der Applikation in der Notfallmedizin.