title: TaqI dimorphic site in a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12.
abstract: We report the identification of a TaqI dimorphic site in the first intron of a human phospholipase A2 gene that has been localized on chromosome 12. This single two-allele polymorphism was detected by DNA blot hybridization using a full-length, 584 bp human phospholipase A2 cDNA isolated from a human lung lambda gt10 cDNA library. Fragment lengths were detected at either 1.3 kb or 2.2 kb. The PIC value of this dimorphism was 0.369 in a random population of 353 Caucasians.
authors.affiliation: Department of Pathology, Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates.
authors.forename: P M
authors.initials: PM
authors.lastname: Frossard
authors.forename: P E
authors.initials: PE
authors.lastname: Newman
authors.forename: G G
authors.initials: GG
authors.lastname: Lestringant
mesh_terms: D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D015252:Deoxyribonucleases, Type II Site-Specific; D005787:Gene Frequency; D006801:Humans; D010179:Pancreas / Q000201:enzymology*; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D011110:Polymorphism, Genetic
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases