title: Establishment of creatinine clearance reference values for older women.
abstract: Age-adjusted reference ranges for creatinine clearance were determined in 279 women, ages 40-95 years, who were housed in a metabolic research unit and consumed a meat-free diet. Creatinine clearance, but not serum creatinine, declined with age by 0.63 mL/min per 1.73 m2 per year. Serum and urine creatinine concentrations, used to calculate clearances, were analyzed by a kinetic Jaffé procedure. In a subset of 100 subjects, fasting serum creatinine values averaged 8.3 +/- 5.2 (SD) mumol/L higher when measured by the kinetic Jaffé procedure than by an enzymatic method (creatinine PAP). The Cockcroft-Gault formula for estimating creatinine clearance from serum creatinine in women was validated, and the modification factor for the male equation was determined to be 0.84 (95% confidence interval 0.83-0.86) confirming the suggested 15% correction. A prediction formula derived from this population was similar in accuracy to the Cockcroft-Gault formula.
authors.affiliation: US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
authors.forename: L J
authors.initials: LJ
authors.lastname: Sokoll
authors.forename: R M
authors.initials: RM
authors.lastname: Russell
authors.forename: J A
authors.initials: JA
authors.lastname: Sadowski
authors.forename: F D
authors.initials: FD
authors.lastname: Morrow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D003404:Creatinine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012016:Reference Values
chemical_list: D003404:Creatinine