Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice.
The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E2, prostaglandin F2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.
Williams
A E
AE
BBSRC and MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, UK.
van Dam
A M
AM
Man-A-Hing
W K
WK
Berkenbosch
F
F
Eikelenboom
P
P
Fraser
H
H
D000818:Animals; D017305:Annexin A1 / Q000032:analysis / Q000378:metabolism*; D000906:Antibodies; D000943:Antigens, Differentiation / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines / Q000032:analysis / Q000378:metabolism*; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology; D018620:PrPSc Proteins; D011453:Prostaglandins / Q000032:analysis / Q000378:metabolism*; D012016:Reference Values; D012608:Scrapie / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014617:Vacuoles / Q000473:pathology
D017305:Annexin A1; D000906:Antibodies; D000943:Antigens, Differentiation; D016207:Cytokines; D005904:Glial Fibrillary Acidic Protein; D007375:Interleukin-1; D018620:PrPSc Proteins; D011453:Prostaglandins; D014409:Tumor Necrosis Factor-alpha; C036763:monocyte-macrophage differentiation antigen; D015237:Dinoprost; D015232:Dinoprostone