title: Lymphomatoid papulosis: a follow-up study of 41 patients.
abstract: Forty-one patients with lymphomatoid papulosis have been followed from 1 to 22 years (mean 11.4 years, median 10 years). Six patients developed malignant lymphoma, 3 cutaneous T-cell lymphoma, 2 Ki-1 large cell lymphoma, and 1 Hodgkin's disease. A clinical malignant presentation combined with the finding of aneuploidy in skin lesions seem to be indications of a malignant potential. Treatment with methotrexate in low dosage is an efficient treatment of lymphomatoid papulosis and probably diminishes the risk of malignancy.
authors.affiliation: Dermatological Department, Rigshospitalet, Copenhagen, Denmark.
authors.forename: H K
authors.initials: HK
authors.lastname: Christensen
authors.forename: K
authors.initials: K
authors.lastname: Thomsen
authors.forename: G L
authors.initials: GL
authors.lastname: Vejlsgaard
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000209:etiology; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000209:etiology; D016410:Lymphoma, T-Cell, Cutaneous / Q000209:etiology; D017731:Lymphomatoid Papulosis / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011701:PUVA Therapy
chemical_list: D008727:Methotrexate