Effects of NC-1300-O-3 on gastric mucus secretion and prostaglandin release in rats.
We investigated the effect of NC-1300-O-3 on gastric mucus secretion and prostaglandin release into the gastric lumen in rats. NC-1300-O-3 following single or repeated administration for up to 4 weeks significantly increased the hexose content in the gastric lumen at 10 to 100 mg/kg, p.o. Omeprazole and cimetidine at doses that strongly inhibited gastric acid secretion had no effect on the hexose content following single or repeated administration for 8 days. When administered repeatedly for 8 days, NC-1300-O-3, omeprazole and cimetidine significantly decreased the hexosamine content in gastric surface mucosa, but significantly increased gastric mucus secretion was observed at the same time only with NC-1300-O-3, indicating that this agent has a profile of action on gastric mucus metabolism different from those of omeprazole and cimetidine. NC-1300-O-3 at 10 and 30 mg/kg, p.o. and omeprazole at 30 mg/kg, p.o. increased the release of prostaglandins into the gastric lumen, and this was markedly inhibited by pretreatment with indomethacin, suggesting that these agents may enhance prostaglandin biosynthesis in the gastric mucosa. From these results, it seems that the enhancement of NC-1300-O-3 on gastric mucus secretion and prostaglandin biosynthesis in the gastric mucosa contribute to the antiulcer effect of NC-1300-O-3.
Matsukura
H
H
Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama, Japan.
Masuda
M
M
Uchida
A
A
Kamishiro
T
T
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology; D015232:Dinoprostone / Q000096:biosynthesis; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009093:Mucus / Q000378:metabolism*; D009853:Omeprazole / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D006595:Hexosamines; D006601:Hexoses; D011453:Prostaglandins; C089751:leminoprazole; D002927:Cimetidine; D015232:Dinoprostone; D009853:Omeprazole; D007213:Indomethacin