Determinants of plasma vitamin E concentrations.
Vitamin E, a lipid soluble antioxidant, is transported in plasma lipoproteins. This review will summarize the mechanisms for the preferential incorporation of RRR-alpha-tocopherol into lipoproteins. Special attention is devoted to the hepatic tocopherol binding protein, and to patients who are vitamin E deficient because they apparently have a genetic defect in this protein. The regulation of plasma vitamin E by the tocopherol binding protein as a determinant of the biologic activity of various forms of vitamin E is also discussed.
Traber
M G
MG
Department of Medicine, New York University School of Medicine, NY 10016.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002914:Chylomicrons / Q000378:metabolism; D030342:Genetic Diseases, Inborn / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D014810:Vitamin E / Q000097:blood*
D002352:Carrier Proteins; D002914:Chylomicrons; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; C017763:alpha-tocopherol transfer protein; D014810:Vitamin E