Dengue virus infects mouse cultured neurons but not astrocytes.
Cultures of mouse brain cells containing a high proportion either neurons or astrocytes were inoculated with various strains of dengue virus. At analysis by double immunofluorescence, all strains of dengue virus studied were tropic for neurons. In no case were the astrocytes infected. Only approximately 10% of all neurons were infected, suggesting that the virus may enter the cell through a membrane receptor present only in a subgroup of neurons.
Imbert
J L
JL
Neurovirology Laboratory, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico.
Guevara
P
P
Ramos-Castañeda
J
J
Ramos
C
C
Sotelo
J
J
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001253:Astrocytes / Q000382:microbiology*; D001921:Brain / Q000166:cytology; D002478:Cells, Cultured; D003593:Cytoplasm / Q000382:microbiology; D003716:Dengue Virus / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009474:Neurons / Q000382:microbiology*; D011991:Receptors, Virus; D014776:Virus Cultivation
D000956:Antigens, Viral; D011991:Receptors, Virus