The power-consumption-controlled extruder: a tool for pellet production.
Based on the assumption that there is a link between power consumption of an extruder and pellet properties, a control circuit for power consumption was developed. Powder and granulation liquid are fed separately into a twin-screw extruder. The power consumption is controlled by varying the pump rate at a given powder-feed rate; consequently each level of power consumption results in a specific water content of the extrudate for a particular formulation. The shape of pellets depends almost entirely on the level of power consumption irrespective of formulation. The size of dry pellets is additionally affected by a shrinking factor which depends on the water content. The power-consumption-controlled extruder is an appropriate tool for the production of pellets. The system is able to adapt the water content for a formulation automatically.
Kleinebudde
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Department of Pharmaceutics and Biopharmaceutics, Christian-Albrechts-University, Kiel, Germany.
Sølvberg
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AJ
Lindner
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D002482:Cellulose / Q000737:chemistry*; D004304:Dosage Forms / Q000592:standards*; D004343:Drug Implants / Q000737:chemistry / Q000592:standards*; D007785:Lactose / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011108:Polymers; D015203:Reproducibility of Results
D004304:Dosage Forms; D004343:Drug Implants; D011108:Polymers; D002482:Cellulose; D007785:Lactose