title: Genetics of osteoporosis.
abstract: Identification of the major contribution of genetic factors in determination of peak bone mass at skeletal maturity and possibly on subsequent age-related bone loss has led to efforts to identify possible mechanisms. Recent evidence suggests one mechanism relates to genetic effects on bone turnover mediated via the vitamin D system. This field of research has potential for reducing osteoporotic fracture risk by allowing interventions at different stages in life to reduce this increasing problem of ageing societies.
authors.affiliation: Garvan Institute of Medical Research, Department of Endocrinology, St Vincent's Hospital, Sydney, Australia.
authors.forename: P N
authors.initials: PN
authors.lastname: Sambrook
authors.forename: P J
authors.initials: PJ
authors.lastname: Kelly
authors.forename: N A
authors.initials: NA
authors.lastname: Morrison
authors.forename: J A
authors.initials: JA
authors.lastname: Eisman
mesh_terms: D000375:Aging / Q000502:physiology; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D010024:Osteoporosis / Q000150:complications / Q000235:genetics*; D018433:Twin Studies as Topic