title: Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study.
abstract: Expansion of the fat stores has been proposed as a prerequisite for increasing fat oxidation in response to a high-fat diet in individuals with a predisposition to obesity. In a cross-sectional design we measured 24-h substrate oxidations on a standardized diet in 38 overweight or obese and 35 nonobese women. Fat oxidation (g/d) was mainly a function of total energy requirements (r = 0.71, P < 0.0001). To account for this we used for further analysis oxidative fat energy (%), a counterpart to dietary fat energy (%). After differences in fat energy of consumed food (%), age, and 24-h energy balance were adjusted for, obese women had higher oxidative fat energy than did nonobese women [40.2% (37.8-42.6) vs 36.0% (33.6-38.5), P < 0.02]. Adjusted oxidative fat energy (%) increased with increasing size of fat mass (r = 0.31, P < 0.01). This relation suggests that a 10-kg change in fat mass may be caused by a change in dietary fat energy of > or = 1.6% (0.4-2.7%). The study supports the concept that in susceptible individuals the expansion of fat stores is a prerequisite to increase the oxidative fat energy to an amount commensurate with a high percentage of dietary fat energy.
authors.affiliation: Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Astrup
authors.forename: B
authors.initials: B
authors.lastname: Buemann
authors.forename: P
authors.initials: P
authors.lastname: Western
authors.forename: S
authors.initials: S
authors.lastname: Toubro
authors.forename: A
authors.initials: A
authors.lastname: Raben
authors.forename: N J
authors.initials: NJ
authors.lastname: Christensen
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000704:Analysis of Variance; D001823:Body Composition; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D010084:Oxidation-Reduction; D017697:Premenopause; D012044:Regression Analysis
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats