[Treatment in the event of antibiotic prophylaxis failure in gynecologic surgery. A retrospective study of 20 cases].
A retrospective study was performed of the type of treatment used in 20 patients undergoing gynecological surgery in whom antibiotic prophylaxis with Mezlocillin (2 g i.v.) had failed. Patients were subdivided into three groups: A) Initial therapy with Mezlocillin (8 patients, 2 g/die i.m.) or Cefotetan (2 patients, 2 g/die i.m.) and subsequent addition of Gentamicin (8 patients, 240 mg/die i.m.) or Tobramycin (2 patients, 200 mg/die i.m.) and subsequently Metronidazole (7 patients, 1.5 g/die per os). B) Therapy with Imipenem/Cilastatin (6 patients, 1.5 g/die i.m.). C) Therapy with Imipenem/Cilastatin (4 patients, 1.5 g/die i.m.) after a variety of antibiotics: Cotrimoxazole (Trimethoprim 160 mg/die and sulphamethoxazole 800 mg/die per os), Pefloxacin (800 mg/die per os), Cefotetan (2 g/die i.m.) and Mezlocillin (2 g/die i.m.). Time taken to lower temperature was shorter in Group B (3.5 days) compared to Group A (6.8 days) and Group C (10 days). Postoperative hospital stay was also shorter in Group B (9 days) compared to Group C (16.5 days) and Group A (11.1 days). The immediate administration of an antibiotic active against Gram+ and Gram- germs, aerobes and anaerobes is therefore useful in the event of failure of antibiotic prophylaxis, rather than the use in succession of associations of antibiotics with a limited spectrum.
Paparella
P
P
Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Roma.
Zullo
M A
MA
Astorri
A L
AL
Bondì
M
M
Maglione
A
A
Oliva
C
C
Mancuso Bondì
S
S
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015377:Cilastatin / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage; D007239:Infections / Q000188:drug therapy*; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D011292:Premedication; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D015377:Cilastatin; D015378:Imipenem
Sul trattamento in caso di fallimento dell'antibiotico-profilassi in chirurgia ginecologica. Esame retrospettivo di 20 casi.