title: Magnetic resonance imaging of skeletal muscles in idiopathic inflammatory myopathies of adults.
abstract: The purpose of the study was to describe typical MRI findings in various types of idiopathic inflammatory myopathies in adulthood and to correlate the MRI with histopathological and electromyographic findings, and the serum creatine kinase (CK) activity. A third goal was to assess the diagnostic value of the use of gadolinium-DTPA (Gd-DTPA). Fifty-eight patients (35 women, 23 men), aged 21-83 years (median age 59 years), suffering from idiopathic myositides (13 with acute and 45 chronic diseases; 25 with polymyositis, 14 with dermatomyositis, 8 with granulomatous and 11 with inclusion body myositides) were examined with MRI. Seventeen of them received an intravenous infusion of Gd-DTPA. Histopathological and MRI findings of 21 muscles of 18 patients were compared. MRI of skeletal muscles showed abnormal signal intensities in 56 (96.6%) of the 58 patients. MRI abnormalities were found more often than elevated CK activity (P < 0.001). The hyperintensity of T2-weighted images was more conspicuous than on T1-weighted images in 26 (44.8%) patients, indicating oedema-like abnormalities. MRI of 50 (86.2%) patients showed fat replacement. In acute myositides, oedema-like abnormalities were more often visible and in muscle lipomatosis less often visible than in chronic diseases (P < 0.05 each). In dermatomyositis oedema-like abnormalities were more and lipomatosis less frequent than in the other types of myositis (P < 0.005) and correlated with the acuteness of the disease.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Friedrich-Baur-Institut bei der Medizinischen und Neurologischen Klinik, Ludwig-Maximilians-Universität, München, Deutschland.
authors.forename: C D
authors.initials: CD
authors.lastname: Reimers
authors.forename: H
authors.initials: H
authors.lastname: Schedel
authors.forename: J L
authors.initials: JL
authors.lastname: Fleckenstein
authors.forename: M
authors.initials: M
authors.lastname: Nägele
authors.forename: T N
authors.initials: TN
authors.lastname: Witt
authors.forename: D E
authors.initials: DE
authors.lastname: Pongratz
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000175:diagnosis; D004487:Edema / Q000473:pathology; D004576:Electromyography; D005260:Female; D019786:Gadolinium DTPA; D006099:Granuloma / Q000175:diagnosis; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008068:Lipomatosis / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009220:Myositis / Q000175:diagnosis*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D012680:Sensitivity and Specificity
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D003402:Creatine Kinase; D019786:Gadolinium DTPA