Cell cycle control and cancer.
Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.
Hartwell
L H
LH
Department of Genetics, University of Washington, Seattle 98195.
Kastan
M B
MB
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016922:Cellular Senescence; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology
D016213:Cyclins; D016159:Tumor Suppressor Protein p53