title: Effect of space flight on the development of endocrine functions in rats.
abstract: The effects of the exposure to space flights on plasma hormone levels were studied in adult male rats, in pregnant females and in their progeny. An increase of plasma corticosterone (CS) and insulin (I) levels was found in male rats after space flights for a period of 7, 15, 18 and 20 days. Plasma levels of growth hormone (GH) were decreased and those of epinephrine (E) and norepinephrine (NE) were elevated in rats exposed to longer space flights (18 or 20 days). In pregnant female rats no significant changes of plasma concentrations of CS, GH, I, E and NE were noted after short term space flight (5 days). However, the plasma prolactin levels were elevated. In young animals exposed to space flight during fetal development no changes of plasma I and prolactin levels were noted during the period of postnatal growth. However, the plasma CS levels were elevated in these rats and no gradual increase of CS plasma concentration was observed during the postnatal period. The plasma GH levels were reduced in rats exposed to space flight and the levels of catecholamines in plasma and in adrenal glands were elevated in 30 and 100 day old rats exposed to microgravity during the fetal development. These results demonstrated: 1. that exposure of rats to space flight is followed by changes in I and CS plasma levels, but the sympathetic-adrenomedullary system is only slightly activated by longer space flights; 2. that a short term space flight is only a mild stressor for pregnant rats and slightly affects the activity of adrenocortical and sympathetic-adrenomedullary systems during the development of their offsprings.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.
authors.forename: L
authors.initials: L
authors.lastname: Macho
authors.forename: D
authors.initials: D
authors.lastname: Jezová
authors.forename: J
authors.initials: J
authors.lastname: Jurcovicová
authors.forename: R
authors.initials: R
authors.lastname: Kvetnanský
authors.forename: M
authors.initials: M
authors.lastname: Vigas
authors.forename: L B
authors.initials: LB
authors.lastname: Serová
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D005314:Embryonic and Fetal Development / Q000502:physiology; D004702:Endocrine Glands / Q000254:growth & development / Q000502:physiology*; D004837:Epinephrine / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013026:Space Flight; D014893:Weightlessness
chemical_list: D011388:Prolactin; D013006:Growth Hormone; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine