The clinical significance of insulin resistance in the treatment of hypertension.
A strong association between arterial hypertension and Type 2 diabetes mellitus has been known for more than 70 years. However, there are many unanswered questions with regard to the hypothesis of a causal relationship between insulin resistance/hyperinsulinaemia and arterial hypertension. At present, there is no hard evidence for a close (causal) linkage between insulin resistance (or hyperinculinaemia) and arterial hypertension. Currently available antihypertensive drugs in prudent and effective dosages do not result in a deterioration of insulin sensitivity, or in the development of insulin resistance, or an increased incidence of Type 2 diabetes mellitus.
Berger
M
M
Department of Metabolic Diseases and Nutrition, Heinrich-Heine-University Düsseldorf, Germany.
Sawicki
P T
PT
D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D007333:Insulin Resistance / Q000502:physiology*
D000959:Antihypertensive Agents