PEG-hemoglobin: an efficient oxygen-delivery system in the rat exchange transfusion and hypovolemic shock models.
Polyethylene glycol-hemoglobin (PEG-Hb is a purified bovine hemoglobin molecule modified by polyethylene glycol. Oxygen delivery to the tissue, in rat exchange transfusion and hypovolemic shock models, was studied to determine whether the oxygen-carrying capacity of PEG-Hb is as efficient as red blood cells.
Nho
K
K
Enzon, Inc., Piscataway, NJ 08854.
Linberg
R
R
Johnson
M
M
Gilbert
C
C
Shorr
R
R
D000009:Abdominal Muscles / Q000378:metabolism; D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D004195:Disease Models, Animal; D005078:Exchange Transfusion, Whole Blood; D006454:Hemoglobins / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D007262:Infusions, Intravenous; D010100:Oxygen / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012769:Shock / Q000378:metabolism / Q000628:therapy*
D001802:Blood Substitutes; D006454:Hemoglobins; D011092:Polyethylene Glycols; D010100:Oxygen