[Effects of paracetamol on glutathione S-transferase activity in mice].
Paracetamol (acetaminophen) 90-150 mg.kg-1 increased the activity of serum glutathione S-transferase (GST) and yet reduced the activities of liver microsomal and homogenate GST in mice. The GST activity was dose- and time-related to paracetamol. A negative correlation was found between serum GST and liver homogenate GST, as well as between serum GST and liver microsomal GST. A good positive correlation between serum GST and serum alanine aminotransferase (AAT) was also seen. In addition, butylated hydroxyanisole (BHA) and sodium ferulate (SF) remarkably reversed the changes of serum GST and serum AAT activities in paracetamol-treated mice. These results suggested that the conjugation level in liver was decreased in paracetamol-induced hepatotoxicity in mice.
Wang
H
H
Department of Pharmacology, Hubei Medical University, Wuhan, China.
Peng
R X
RX
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D003373:Coumaric Acids / Q000494:pharmacology; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology
D003373:Coumaric Acids; D002083:Butylated Hydroxyanisole; D000082:Acetaminophen; C004999:ferulic acid; D005982:Glutathione Transferase; D000410:Alanine Transaminase