title: A miniaturized centrifugal pump for assist circulation.
abstract: The newly developed Nikkiso HMS-15 is a miniaturized centrifugal pump. It has an impeller diameter of only 50 mm and a priming volume of only 25 ml. A totally new approach was applied to develop this very small pump. The new pump showed comparable hemolysis with pumps twice as big (e.g., the most widely used cone-shaped centrifugal pump [index of hemolysis, 0.005]). This finding refutes the belief that the pump diameter must be sufficiently large in size. Clinical application for cardiac assist was performed for 48 h without any thrombus formation despite low heparin dosage. Also, the pump showed quite favorable blood trauma when applied as a pump for cardiopulmonary bypass during open heart surgery. The compactness, the high controllability, and the system versatility proved to be very effective for clinical application. This pump is considered very reliable for its highly optimized design.
authors.affiliation: Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: R
authors.initials: R
authors.lastname: Yozu
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: S
authors.initials: S
authors.lastname: Kawada
mesh_terms: D000368:Aged; D000818:Animals; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D002417:Cattle; D004867:Equipment Design; D005260:Female; D006353:Heart-Assist Devices / Q000009:adverse effects; D006461:Hemolysis; D006801:Humans; D008904:Miniaturization