[The correction of disorders of the internal body environment in animals and man by the addition of succinic acid to food].
Succinic acid is involved in correction of energy metabolism as a powerful source of protons and ATP and as an antioxidant. Some food products contain succinic acid, specifically those, whose preparation involves anaerobic processes, and some berries. However many everyday food products are devoid of succinic acid. The lack of succinic acid in food can be compensated by its use as a food additive. It has been shown that consumption of succinic acid by rats results in a decreased weight increment of adult animals kept on abundant sugar diet. Both therapeutical (higher) and nutritive (lower) doses of succinic acid decrease metabolic acidosis and restore the transaminase activity in patients. The both metabolic parameters indicate correction of energy metabolism.
Saakian
M R
MR
Kondrashova
M N
MN
Vysochina
I V
IV
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002951:Citrates / Q000627:therapeutic use; D019343:Citric Acid; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D051381:Rats; D013386:Succinates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019802:Succinic Acid; D013997:Time Factors
D002951:Citrates; D004040:Dietary Carbohydrates; D005503:Food Additives; D013386:Succinates; D019343:Citric Acid; D019802:Succinic Acid
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