[Involvement of free radicals in lead poisoning].
The following proves that free radicals are involved in lead poisoning: An enolamine form of 5-aminolevulinic acid (ALA), a haem precursor which accumulates in the body of lead poisoned patients undergoes fast autooxidation with concomitant generation of reactive oxygen species. The transmembrane potential and calcium ions fluxes of isolated rat mitochondria are strongly affected by ALA. This toxic effect is inhibited by antioxidant enzymes. Induction of antioxidant enzymes' activity was observed in lead-exposed workers.
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Katedry i Zakładu Chemii i Analizy Leków Akademii Medycznej, Katowicach.
D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007855:Lead Poisoning / Q000503:physiopathology*; D009784:Occupational Diseases / Q000503:physiopathology; D051381:Rats
D005609:Free Radicals
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