Effects of novobiocin on the induction of gamma-glutamyltranspeptidase positive foci in the liver of rats treated with diethylnitrosamine.
Effects of novobiocin on the induction of gamma-glutamyltranspeptidase(GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, after diethylnitrosamine(DEN) initiation were investigated in Fischer 344 rats. Animals were given DEN at a dose of 20 mg/kg b. w. followed by novobiocin at doses of 50, 100 and 200 mg/kg b. w. The latter two doses, but not 50 mg/kg b. w., significantly inhibited the development of GGT-positive foci, providing evidence of the possible involvement of mono(ADP-ribosyl)ation in the initiation phase of hepatocarcinogenesis in rats.
Tsujiuchi
T
T
Department of Oncological Pathology, Cancer Center, Nara Medical College, Kashihara, Japan.
Tsutsumi
M
M
Honoki
K
K
Horiguchi
K
K
Kobayashi
E
E
Denda
A
A
Konishi
Y
Y
D036002:ADP Ribose Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D004052:Diethylnitrosamine; D004790:Enzyme Induction / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D009675:Novobiocin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D016588:Anticarcinogenic Agents; D009675:Novobiocin; D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase; D036002:ADP Ribose Transferases