title: [Evaluation of exocrine pancreatic insufficiency in cirrhotic patients,using the fecal chymotrypsin test].
abstract: In spite of having been the object of a number of studies, the association of morphologic and functional alterations of the pancreas with liver cirrhosis is as yet controversial. Therefore, the authors have studied exocrine pancreatic function in 40 patients: 8 with alcoholic cirrhosis, 18 with non-alcoholic cirrhosis, and 14 without evidence of hepatobiliary and pancreatic pathology. Pancreatic function was studied by the fecal chymotrypsin test which is sufficiently sensitive and specific and has been preferred in view of its practicability and non-invasiveness. Analysis of the results showed pathologic values to be significantly more frequent in subjects with alcoholic cirrhosis (50%, p < 0.05) compared to non-alcoholic cirrhotics (11.11%) and to controls (7.2%). These findings go to show that pancreatic exocrine deficit is frequently associated with alcoholic cirrhosis, thus confirming what has already been known about the pathogenetic role of alcohol which is apt to provoke both hepatic and pancreatic damage. Finally, it should be pointed out that pancreatic exocrine deficit is a purely functional alteration without clinical manifestations.
authors.affiliation: Istituto di Idrologia Medica, Università degli Studi di Roma La Sapienza.
authors.forename: M
authors.initials: M
authors.lastname: Grassi
authors.forename: S
authors.initials: S
authors.lastname: Lazzari
authors.forename: P
authors.initials: P
authors.lastname: Palmisano
authors.forename: S
authors.initials: S
authors.lastname: Nocchi
authors.forename: M
authors.initials: M
authors.lastname: Fontana
authors.forename: S
authors.initials: S
authors.lastname: Raffa
authors.forename: M
authors.initials: M
authors.lastname: Antonelli
mesh_terms: D000368:Aged; D002918:Chymotrypsin / Q000032:analysis*; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis / Q000209:etiology; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000378:metabolism; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000209:etiology*; D010186:Pancreatic Function Tests
chemical_list: D002918:Chymotrypsin
vernacular_title: Valutazione dell'insufficienza pancreatica esocrina nei cirrotici con il test della chimotripsina fecale.