Nuclear transcription factors: potential targets for new modes of intervention in skin disease.
Many drugs already in use for the treatment of skin disease, including steroids, retinoids, vitamin D derivatives and cyclosporin (CyA), exert effects on gene transcription. In this review we briefly outline how these drugs work, before proceeding to a consideration of how new drugs acting on the transcription process might be used to influence skin disease.
McKay
I A
IA
Department of Experimental Dermatology, London Hospital Medical College, U.K.
Winyard
P
P
Leigh
I M
IM
Bustin
S A
SA
D015195:Drug Design; D005544:Forecasting; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy* / Q000235:genetics; D014157:Transcription Factors / Q000187:drug effects*; D014158:Transcription, Genetic / Q000187:drug effects*
D014157:Transcription Factors