title: Estimation of cardiac index by means of the arterial and the mixed venous oxygen content and pulmonary oxygen uptake determination in the early post-operative period following surgery of congenital heart disease.
abstract: OBJECTIVE
  To assess the reliability of estimation of cardiac index based on the mixed venous oxygen saturation and methods of improving the estimation of cardiac index.
  
  
  METHODS
  PICU in an university hospital.
  
  
  METHODS
  In the post-operative period following complete repair of congenital heart disease we carried out 55 measurements of blood gases in 25 infants and children (mean age 16.1 months, mean body surface 0.43 m2) from a systemic artery (arterial) and the pulmonary artery (mixed venous). We also determined the pulmonary oxygen uptake and calculated the cardiac index (CI) using Fick's principle. In the analysis we compared the CI with the mixed venous oxygen saturation (SvO2) and with the quotient of the arterial oxygen content (CaO2) and the oxygen extraction (Ca-vDO2). This quotient is equal to arterial oxygen delivery (DO2) divided by the oxygen consumption (VO2).
  
  
  RESULTS
  Pearson's correlation coefficient was 0.77 when SvO2 was compared to CI in a linear regression model. Assuming an inverse relationship between SvO2 and CI the correlation was much better (r = 0.90). However, the best estimation of CI provides the quotient CaO2/Ca-vDO2 (r = 0.93).
  
  
  CONCLUSIONS
  CaO2/Ca-vDO2 correlates much better with CI than the SvO2, therefore CI could be better estimated based on CaO2/Ca-vDO2. Furthermore CaO2/Ca-vDO2 provides good information about the oxygen supply situation of the body.
authors.affiliation: University Children Hospital Erlangen, Department of Cardiology, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Buheitel
authors.forename: J
authors.initials: J
authors.lastname: Scharf
authors.forename: M
authors.initials: M
authors.lastname: Hofbeck
authors.forename: H
authors.initials: H
authors.lastname: Singer
mesh_terms: D001158:Arteries; D001784:Blood Gas Analysis; D002302:Cardiac Output; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D008168:Lung / Q000378:metabolism; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D010101:Oxygen Consumption; D011184:Postoperative Period; D015203:Reproducibility of Results; D014680:Veins
chemical_list: D010100:Oxygen