title: Acquired von Willebrand disease in twins with autoimmune hypothyroidism: response to desmopressin and L-thyroxine therapy.
abstract: Because of menorrhagia, a 13-year-old girl was found to have type I von Willebrand disease and then chronic autoimmune thyroiditis with hypothyroidism. All clinical and laboratory evidence of von Willebrand disease resolved transiently after infusion of desmopressin, and permanently with L-thyroxine therapy. We recommend investigation for hypothyroidism in patients with newly diagnosed acquired von Willebrand disease.
authors.affiliation: Department of Pediatrics, University of Utah Medical Center, Salt Lake City.
authors.forename: C S
authors.initials: CS
authors.lastname: Bruggers
authors.forename: K
authors.initials: K
authors.lastname: McElligott
authors.forename: M L
authors.initials: ML
authors.lastname: Rallison
mesh_terms: D000293:Adolescent; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D004200:Diseases in Twins; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007262:Infusions, Intravenous; D013967:Thyroiditis, Autoimmune / Q000150:complications*; D013974:Thyroxine / Q000627:therapeutic use*; D014842:von Willebrand Diseases / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D003894:Deamino Arginine Vasopressin; D013974:Thyroxine