title: Use of membranes containing 20% chlorhexidine and 40% doxycycline for treatment of chronic periodontal pockets.
abstract: A study was carried out to compare the effects of subgingival applications of resorbable hydroxypropylmethylcellulose (HPMC) membranes containing 20% chlorhexidine (CHx) and 40% doxycycline (DOXY) placed subgingivally in periodontal pockets greater than 5 mm in depth. Each of 11 patients had at least four pockets. HPMC strips containing CHx and DOXY were inserted into each pocket twice a week for 6 w. One pocket was kept as a control and the other received subgingival scaling and root planing at 0, 1, 3 and 6 w. The microbial flora of 44 pockets from the 11 patients was examined using dark-field microscopy at the baseline and at 1, 3, 6 and 10 w. Clinical parameters including probing depth, crevicular fluid flow, bleeding on probing and gingival shrinkage were also recorded. The CHx and DOXY-administered or root-planed pockets showed marked reduction of both pocket depth and the number of motile organisms. Less bleeding was also observed in CHx and DOXY-inserted pockets.
authors.affiliation: Department of Periodontology, Gazi University School of Dentistry, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Ozcan
authors.forename: I L
authors.initials: IL
authors.lastname: Taner
authors.forename: T
authors.initials: T
authors.lastname: Doğanay
authors.forename: M
authors.initials: M
authors.lastname: Iscanoğlu
authors.forename: B
authors.initials: B
authors.lastname: Taplamacioğlu
authors.forename: S E
authors.initials: SE
authors.lastname: Gültekin
authors.forename: K
authors.initials: K
authors.lastname: Baloş
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001673:Biodegradation, Environmental; D002710:Chlorhexidine / Q000008:administration & dosage*; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D065347:Hypromellose Derivatives; D008297:Male; D008567:Membranes, Artificial; D008747:Methylcellulose / Q000031:analogs & derivatives; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D004318:Doxycycline; D002710:Chlorhexidine