title: Monospermic polyploidy and atypical embryo morphology.
abstract: Monospermic cleavage-arrested human embryos were analysed by fluorescence in-situ hybridization using specific DNA probes for chromosomes X, Y and 18 simultaneously. Two groups of monospermic polyploid embryos could be distinguished: (i) embryos (n = 13) with only one large cell surrounded by smaller blastomere-sized extracellular fragments. These embryos were polyploid and frequently polyploid mosaic. (ii) Embryos developing from larger than normal oocytes were triploid or triploid mosaics (n = 4). Atypical morphology was not seen in eight other polyploid monospermic embryos. The atypical morphologies described here are quite rare, but are genetically uniform. Polyspermic embryos are the only other known example of a dual genetic-morphological abnormality.
authors.affiliation: Department of Obstetrics and Gynecology, New York Hospital--Cornell University Medical Center, NY 10021.
authors.forename: S
authors.initials: S
authors.lastname: Munné
authors.forename: M
authors.initials: M
authors.lastname: Alikani
authors.forename: J
authors.initials: J
authors.lastname: Cohen
mesh_terms: D001757:Blastomeres / Q000648:ultrastructure*; D002887:Chromosomes, Human, Pair 18; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011123:Polyploidy; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D015342:DNA Probes; D004247:DNA