Effect of age and disease on two drug binding proteins: albumin and alpha-1- acid glycoprotein.
The influence of age and disease on serum albumin and alpha-1-acid glycoprotein was studied in 126 subjects (69 M, 57 F) presenting with tuberculosis and after recovery. Albumin concentration fell with age in both disease and healthy states, and alpha-1-acid glycoprotein concentration rose with age in the healthy state. Age-related differences were less marked in the disease state. During recovery from illness, serum albumin concentration rose and alpha-1-acid glycoprotein concentration fell. The mean concentration difference in the latter was lower in the older age groups. The clinical consequences of changes in binding protein concentrations as a result of ageing and disease need to be studied further for individual drugs.
Woo
J
J
Department of Medicine, Faculty of Medicine, Chinese University of Hong Kong.
Chan
H S
HS
Or
K H
KH
Arumanayagam
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D014376:Tuberculosis / Q000097:blood* / Q000188:drug therapy
D009961:Orosomucoid; D012709:Serum Albumin