Reactivity to novelty during youth as a predictive factor of cognitive impairment in the elderly: a longitudinal study in rats.
A life-span study of certain behavioral traits was conducted in rats. Animals were repeatedly tested in a circular corridor for reactivity to novelty and in a recognition memory task for cognitive abilities. These measures revealed important inter-individual differences in young as well as in old subjects. Some of these differences appear with aging (memory deficits) and others disappear (high reactivity to novelty). Moreover, a relationship between high reactivity to novelty in youth and deficits in memory recognition in elderly was found. Rats that are high-responders to novelty had age-related memory impairments whereas the low-responder rats did not. While the biological mechanism linking these two behavioral traits remains to be demonstrated, this study shows that age-related impairments can be predicted by factors detectable early in life.
Dellu
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Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U.259, Université de Bordeaux II, France.
Mayo
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Vallée
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Le Moal
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Simon
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D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D003072:Cognition Disorders / Q000209:etiology*; D005106:Exploratory Behavior; D005544:Forecasting; D007206:Individuality; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors