Penicillamine-induced elastosis perforans serpiginosa treated successfully with isotretinoin.
Elastosis perforans serpiginosa (EPS) and the elastotic changes of pseudoxanthoma elasticum (PXE) are rare but well-recognized side-effects of long-term penicillamine therapy. A 42-year old female patient who developed both of these cutaneous side-effects following treatment with high-dose penicillamine for Wilson's disease is described; near-complete resolution of the EPS, but not the PXE was achieved by treatment with isotretinoin (0.5 mg/kg/day) for 6 weeks, despite continuation of the penicillamine.
Ratnavel
R C
RC
Department of Dermatology, Cambridge University Teaching Hospitals, UK.
Norris
P G
PG
D000328:Adult; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D010396:Penicillamine / Q000009:adverse effects*; D011561:Pseudoxanthoma Elasticum / Q000139:chemically induced / Q000188:drug therapy; D012871:Skin Diseases / Q000139:chemically induced* / Q000188:drug therapy*
D015474:Isotretinoin; D010396:Penicillamine