Successful treatment of extensive posttraumatic soft-tissue and renal infections due to Apophysomyces elegans.
We describe the clinical course and successful treatment of a previously healthy man who, after experiencing trauma, presented with severe cutaneous mucormycosis due to Apophysomyces elegans and subsequently developed secondary renal infection. A multidisciplinary approach employing aggressive surgical debridement and therapy with hyperbaric oxygen, liposomal amphotericin B, and interferon-gamma was successful in controlling his infection, obviating the need for nephrectomy.
Okhuysen
P C
PC
Center for Infectious Diseases, University of Texas Health Science Center at Houston 77030.
Rex
J H
JH
Kapusta
M
M
Fife
C
C
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D006801:Humans; D006931:Hyperbaric Oxygenation; D007371:Interferon-gamma / Q000627:therapeutic use; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000382:microbiology / Q000628:therapy*; D008081:Liposomes; D008297:Male; D009090:Mucorales / Q000254:growth & development / Q000302:isolation & purification; D009091:Mucormycosis / Q000628:therapy*; D018461:Soft Tissue Infections / Q000382:microbiology / Q000628:therapy*; D017695:Soft Tissue Injuries / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
D008081:Liposomes; D000666:Amphotericin B; D007371:Interferon-gamma