Elimination of antipyrine and its metabolites in interferon treated hepatitis C.
1. To study the effect of interferon on hepatic drug metabolism in chronic hepatitis C, we examined nine patients before and at the end of 6 months of interferon treatment. 2. Routine liver function was determined together with the salivary clearance of antipyrine and the 48 h urinary excretion of the main metabolites of antipyrine: 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine before and after 6 months of interferon treatment. 3. Liver pathology, routine liver function, and antipyrine metabolism remained unchanged after patients were treated for 6 months with interferon for a histologically advanced but clinically compensated chronic hepatitis C.
Sieck
J O
JO
Department of Medicine, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
el-Yazigi
A
A
Ali
H
H
Døssing
M
M
Saour
J
J
Raines
D A
DA
Ernst
P
P
D000284:Administration, Oral; D000328:Adult; D000983:Antipyrine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012529:Saudi Arabia
D016898:Interferon-alpha; D000983:Antipyrine