[Candida infection in surgery].
Candida sepsis in surgical patients is rare, but accounting for a high lethality. The diagnosis of a candidemia is based by most authors upon two positive blood cultures in 24 h or on proof of fungi in an organ parenchyma or a normally sterile body cavity. The risk factors for the development of a candida sepsis are administration of broad spectrum antibiotics, invasive monitoring, underlying diseases affecting the immune response and surgery itself. We have checked the charts of 22,740 patients of our clinic from 1987-1992. We found 11 patients (6 male, 5 female) with a mean age of 53.2 (34-76) years with a candida sepsis. The known risk factors for the development of a candida sepsis could be confirmed: broad spectrum antibiotics 100%, invasive monitoring 100%, condition after operation 64%, nasogastric tube 54%, condition after endoscopy 45%, steroid medication 36%. Lethality was 27% (3/11); two out of three patients with a multiple organ system failure died. Recently, it has been shown that mortality was associated with older age and concomitant multiple organ system failure. The treatment of choice for fungal sepsis is intravenous amphotericin B. Finally therapeutic guidelines, the indication for a selective bowel decontamination and the question of prophylaxis with antifungal agents in all postoperative patients are discussed.
Naef
M
M
Universitätsklinik für Viszerale und Transplantationschirurgie, Inselspital, Bern.
von Overbeck
J
J
Seiler
C
C
Baer
H U
HU
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D002177:Candidiasis / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D003428:Cross Infection / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D005260:Female; D016469:Fungemia / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D011292:Premedication; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D015996:Survival Rate
D000900:Anti-Bacterial Agents
Candida-Sepsis in der Chirurgie.