title: The effect of additive hyaluronic acid on animal joints with experimentally reduced lubricating ability.
abstract: A series of in vitro experiments demonstrated a clear effect of additive hyaluronic acid (HA) on animal joints with experimentally reduced lubricating ability. Eleven canine hip joints were utilized and the experimental conditions tested were: i) intact joints, ii) after washing the joint surfaces, and iii) after adding 1% HA to them. The frictional coefficient of every joint increased after washing and subsequently decreased after adding HA. The mean values were 0.007 (SD 0.004) on the intact joints, 0.020 (SD 0.009) after washing, and 0.013 (SD 0.005) after the addition of HA. The differences between the three values of frictional coefficients were shown to be statistically significant (p < 0.01).
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mabuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Obara
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D004285:Dogs; D017276:Friction; D006621:Hip Joint / Q000187:drug effects / Q000502:physiology; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007596:Joints / Q000187:drug effects*; D008153:Lubrication
chemical_list: D006820:Hyaluronic Acid