The abundance of mRNA for dopamine D2 receptor isoforms in brain tissue from controls and schizophrenics.
The possibility that schizophrenia is associated with a differential expression, in the brain, of the short and long isoforms of the dopamine D2 receptor has been investigated by assessing the abundance of mRNA for each of the isoforms. Using a quantitative RNA-PCR technique, increased mRNA for both isoforms of the D2 receptor were observed in some brain regions, with no differential distribution between the isoforms in the schizophrenics compared to controls.
Roberts
D A
DA
Division of Neuroscience, University of Manchester, UK.
Balderson
D
D
Pickering-Brown
S M
SM
Deakin
J F
JF
Owen
F
F
D001483:Base Sequence; D001923:Brain Chemistry / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000378:metabolism*
D012333:RNA, Messenger; D017448:Receptors, Dopamine D2