Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment.
The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.
Sharma
R P
RP
Department of Psychiatry, University of Illinois at Chicago.
Bissette
G
G
Janicak
P
P
Davis
J M
JM
Nemeroff
C B
CB
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D012016:Reference Values; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013004:Somatostatin / Q000134:cerebrospinal fluid*
D014150:Antipsychotic Agents; D013004:Somatostatin