title: [Evaluation of the participation of proinsulin in hyperinsulinism in patients with obesity and glucose intolerance].
abstract: The comparison of the results of two insulin assays, a RIA using a polyclonal antibody and a EMIA using two monoclonal antibodies in blood samples collected during an oral glucose load in normal, obese, glucose intolerant and type II diabetic patients indicated that hyperinsulinemia of obese and glucose intolerant patients is not associated to increased proinsulin/insulin ratio.
authors.affiliation: Service de médecine interne, Hôpitaux Universitaires, Strasbourg.
authors.forename: J F
authors.initials: JF
authors.lastname: Blicklé
authors.forename: R
authors.initials: R
authors.lastname: Sapin
authors.forename: F
authors.initials: F
authors.lastname: Caro-Sampara
authors.forename: F
authors.initials: F
authors.lastname: Grasser
authors.forename: J M
authors.initials: JM
authors.lastname: Brogard
mesh_terms: D000328:Adult; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications*; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D011384:Proinsulin / Q000097:blood*
chemical_list: D011384:Proinsulin
vernacular_title: Evaluation de la participation de la proinsuline dans l'hyperinsulinisme des obèses et intolérants au glucose.