[Pharmacokinetics of harringtonine liposomes in rabbits].
After i.v. free harringtonine (FH) and harringtonine liposomes (HL) with high and low encapsulation percentage (En%) to rabbits, their blood concentrations were determined by reverse-phase HPLC. The blood concentration-time curves were shown to fit a two-compartments open model. FH: T1/2 alpha = 1.32 +/- 0.24, T1/2 beta = 32 +/- 6 min; Low En % HL: T1/2 alpha = 4.12 +/- 0.25, T1/2 beta = 106 +/- 5 min; High En % HL: T1/2 alpha = 9.4 +/- 1.2, T1/2 beta = 209 +/- 5 min.
Wu
H L
HL
Nanjing Institute of Materia Medica, China.
Weng
G Y
GY
Wu
Z H
ZH
Lu
Y C
YC
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004337:Drug Carriers; D005260:Female; D006248:Harringtonines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008081:Liposomes; D008297:Male; D011817:Rabbits
D004337:Drug Carriers; D006248:Harringtonines; D008081:Liposomes