title: Explicit memory, procedural learning and lexical priming in Alzheimer's disease.
abstract: Different aspects of memory functions were studied in two groups of patients with Alzheimer's disease (AD) and in normal elderly controls. The tests included: explicit memory tests with free and cued recall, and recognition measures; learning of a motor skill; learning of a perceptual skill with verbal material; a priming task with the word stem completion paradigm. The data confirmed that, besides severe impairment for all measures of explicit memory, AD patients were able to learn and retain normally a motor skill in the rotor pursuit task, even across a long retention interval. Moreover, sparing of procedural learning was not restricted to motor tasks, since patients learned normally a mirror-reading task, demonstrating (a) rapid acquisition of the procedure, and (b) acquisition of item-specific information for repeated words. This last effect is accounted for in terms of repetition priming effects rather than of explicit memory strategies, since patients had also normal repetition effect in the word stem completion paradigm.
authors.affiliation: INSERM U 289, Hôpital de la Salpêtrière, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Deweer
authors.forename: A M
authors.initials: AM
authors.lastname: Ergis
authors.forename: P
authors.initials: P
authors.lastname: Fossati
authors.forename: B
authors.initials: B
authors.lastname: Pillon
authors.forename: F
authors.initials: F
authors.lastname: Boller
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: B
authors.initials: B
authors.lastname: Dubois
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D000849:Anomia / Q000175:diagnosis / Q000523:psychology; D001288:Attention; D006801:Humans; D011939:Mental Recall; D008875:Middle Aged; D009949:Orientation; D010153:Paired-Associate Learning; D011597:Psychomotor Performance; D011930:Reaction Time; D012153:Retention, Psychology; D014706:Verbal Learning; D014888:Wechsler Scales