Acute myeloid leukemia subtypes and response to treatment among ethnic minorities in a large US urban hospital.
From January 1, 1987, to August 30, 1991, 86 consecutive new cases of AML diagnosed at the LAC-USC Medical Center were analyzed. A significant difference in the FAB subtypes of AML was observed among different racial groups, with AML-M3 more common in Latinos (40%) and AML-M2 in Orientals (52%). Sixty-seven patients received induction chemotherapy with TAD (thioguanine-cytosine arabinoside-daunorubicin) or like regimens. Median follow-up time of all patients was 16 months. Forty-three patients (64%) achieved complete remission. The median overall survival of those who received induction was 10.5 months. The complete remission rates and overall survival were similar among patients of different ethnic backgrounds.
Keung
Y K
YK
Division of Hematology, University of Southern California, Los Angeles.
Chen
S C
SC
Groshen
S
S
Douer
D
D
Levine
A M
AM
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006786:Hospitals, Urban / Q000706:statistics & numerical data; D006801:Humans; D007951:Leukemia, Myeloid / Q000145:classification / Q000208:ethnology* / Q000401:mortality / Q000628:therapy*; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis