Similar ectopic expression of ICAM-1 and HLA class II molecules in hypertrophic scars following thermal injury.
In previous studies we have shown that HLA Class II antigens are expressed by keratinocytes and fibroblasts in hypertrophic scars. Because of the potential role of immunological events in the pathogenesis of hypertrophic scars, in the present study we have tested hypertrophic scars for the expression of intercellular adhesion molecule-1 (ICAM-1), a molecule which plays an important role in immunological phenomena. Immunoperoxidase staining with anti-ICAM-1 MoAb of 10 hypertrophic scar samples detected this molecule on epidermal keratinocytes and on about 30 per cent of fibroblasts at the site of lymphoid infiltration. The expression of ICAM-1 in hypertrophic scars was similar to that of HLA Class II antigens. Since the concomitant expression of ICAM-1 and HLA Class II by keratinocytes is known to enhance their antigen-presenting properties, the present results support the possibility that immunological events play a role in the disruption of the normal processes of wound healing and tissue remodelling which result in hypertrophic scars.
Castagnoli
C
C
Department of Genetics, Biology and Medical Chemistry, Turin University, Italy.
Stella
M
M
Magliacani
G
G
Ferrone
S
S
Richiardi
P M
PM
D000328:Adult; D002056:Burns / Q000150:complications / Q000276:immunology* / Q000473:pathology; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D015603:Keratinocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D018799:Intercellular Adhesion Molecule-1