Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The 1H and 13C NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).
Sawa
R
R
Institute of Microbial Chemistry, Tokyo, Japan.
Takahashi
Y
Y
Itoh
S
S
Shimanaka
K
K
Kinoshita
N
N
Homma
Y
Y
Hamada
M
M
Sawa
T
T
Naganawa
H
H
Takeuchi
T
T
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D005285:Fermentation; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011714:Pyrans; C073564:aldecalmycin