title: Combined valve and coronary artery bypass surgery: early and late results.
abstract: Determinants of early, late and event-free survival of combined valve and coronary artery bypass graft (CABG) surgery were studied in 420 patients using multivariate analysis. It was found that the risk of hospital death increases 5 times when the preoperative NYHA class was > or = IV, 3 times when left ventricular (LV) function is significantly impaired and is double when mitral regurgitation is present. The survival probability of hospital survivors was 91% (87.3-94.5%) at 5 years. Late mortality was determined by advanced preoperative NYHA class ( > or = IV) and the presence of mitral regurgitation. The event-free survival probability of hospital survivors, i.e. total events including death, valve-related complications, ischemic complications and recurrent NYHA class > or = IV, was 73.0% (66.7-79.5%) at 5 years. Postoperative events were determined by the presence of preoperative NYHA class > or = IV, impaired ventricular function, mitral regurgitation and non-sinus rhythm. It is concluded that these parameters can be considered as the most important predictors of clinical outcome after combined valve and CABG surgery.
authors.affiliation: Department of Cardiac Surgery, Katholieke Universiteit Leuven, Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Flameng
authors.forename: J
authors.initials: J
authors.lastname: Szécsi
authors.forename: P
authors.initials: P
authors.lastname: Sergeant
authors.forename: W
authors.initials: W
authors.lastname: Daenen
authors.forename: P
authors.initials: P
authors.lastname: Herijgers
authors.forename: I
authors.initials: I
authors.lastname: Scheys
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000401:mortality; D012086:Reoperation; D016019:Survival Analysis; D015996:Survival Rate; D016277:Ventricular Function, Left / Q000502:physiology