An unusual case of severe griseofulvin-alcohol interaction.
Drug-alcohol interactions in patients who present to emergency departments with a severe "disulfiram-like" illness (including vomiting, diarrhea, flushing, tachycardia, and hypotension) must be recognized and treated appropriately. We report a case of such an interaction caused by oral griseofulvin and alcohol. Emergency physicians should be aware of this potential interaction.
Fett
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DL
Division of Emergency Medical Services and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Vukov
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LF
D004357:Drug Synergism; D000431:Ethanol / Q000009:adverse effects*; D005483:Flushing / Q000139:chemically induced*; D006118:Griseofulvin / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy; D010292:Paresthesia / Q000139:chemically induced; D013610:Tachycardia / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced*
D006118:Griseofulvin; D000431:Ethanol