Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.
Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of nitrogen- and oxygen-derived oxidants. The results support the hypothesis that the phenoloxidase enzyme system contributes to virulence by protecting C. neoformans against nitrogen- and oxygen-derived oxidative antimicrobial molecules produced by immune effector cells.
Wang
Y
Y
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Casadevall
A
A
D000935:Antifungal Agents / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity; D005609:Free Radicals; D008543:Melanins; D009569:Nitric Oxide / Q000494:pharmacology*; D010084:Oxidation-Reduction
D000935:Antifungal Agents; D005609:Free Radicals; D008543:Melanins; D009569:Nitric Oxide