Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft.
A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.
Lane
K L
KL
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Brown
P
P
Howell
D N
DN
Crain
B J
BJ
Hulette
C M
CM
Burger
P C
PC
DeArmond
S J
SJ
D000328:Adult; D001139:Arnold-Chiari Malformation / Q000473:pathology / Q000601:surgery*; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003094:Collagen / Q000009:adverse effects*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000473:pathology / Q000635:transmission*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000473:pathology
C032281:Lyodura; D003094:Collagen