Coatomer-rich endoplasmic reticulum.
We identify in normal cells the existence of two distinct sites of the transitional endoplasmic reticulum (ER), one housing the Sec23p protein complex (the classical transitional element), the other the coatomer protein complex (the coatomer-rich ER). Experimental conditions that reduce transport from the ER to the Golgi complex lead to the overexpression of this newly defined coatomer-rich ER.
Orci
L
L
Department of Morphology, University of Geneva Medical School, Switzerland.
Perrelet
A
A
Ravazzola
M
M
Amherdt
M
M
Rothman
J E
JE
Schekman
R
R
D000818:Animals; D000968:Antimycin A / Q000031:analogs & derivatives / Q000494:pharmacology; D002966:Clathrin / Q000032:analysis / Q000378:metabolism; D004140:Dinitrophenols / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D006056:Golgi Apparatus / Q000378:metabolism / Q000648:ultrastructure; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000378:metabolism / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000032:analysis* / Q000378:metabolism; D008961:Models, Structural; D011506:Proteins / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D033921:Vesicular Transport Proteins
D002966:Clathrin; D004140:Dinitrophenols; D008565:Membrane Proteins; D011506:Proteins; C512740:Sec23a protein, rat; D033921:Vesicular Transport Proteins; C032456:antimycin; D000968:Antimycin A