title: Caloporoside, a new inhibitor of phospholipases C from Caloporus dichrous (Fr.) Ryv.
abstract: A new salicylic acid derivative, caloporoside, was isolated from fermentations of Caloporus dichrous. Its structure was elucidated by a combination of chemical and spectroscopic methods. Caloporoside exhibits weak antibacterial and antifungal activities and is a quite selective inhibitor of phospholipase C isolated from pig brain (Ki 12, 3 microM).
authors.affiliation: Department of Biotechnology, University of Kaiserslautern, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: P
authors.initials: P
authors.lastname: Schu
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: R
authors.initials: R
authors.lastname: Velten
authors.forename: W
authors.initials: W
authors.lastname: Steglich
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008358:Mannose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013552:Swine; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D012459:Salicylates; C091111:caloporoside; D010738:Type C Phospholipases; D008358:Mannose