[Nuclear magnetic resonance tomography findings in obsessive-compulsive disorder].
Eighteen patients with a DSM-III-R diagnosis of obsessive-compulsive disorder (OCD) were imaged by MR and compared to a control group of 18 patients with clinically diagnosed unspecific headaches. Weighted spin-echo sequences were carried out with a 1.5T unit in both axial and coronal planes T1 (TR 700/TE 15 ms) and T2 (TR 2500/TE 15.70). The ferritin distributions in the basal ganglia and in the midbrain were evaluated; in addition, the width of the pars compacta in the midbrain on the basis of the criteria of Braffmann et al. 1988, the widths of the inner subarachnoid spaces on the basis of the ventricular index quotient VIQ (TerBrugge, 1986), and the widths of the outer subarachnoid spaces were conducted. The latter was undertaken by three independent investigators whose results were in agreement with one another. In 12 of the OCD patients (n = 18) there was a total of 25 pathological MRI findings; in the control group there were 6 pathological MRI findings in only 6 of the patients (n = 18). In conclusion pathological changes were found at different locations, but a connection between a specific neuroanatomic system and obsessive-compulsive disorder could not be demonstrated.
Zitterl
W
W
Universitätsklinik für Psychiatrie, Universität Wien.
Wimberger
D
D
Demal
U
U
Hofer
E
E
Lenz
G
G
D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D002552:Cerebral Ventricles / Q000473:pathology; D005260:Female; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D013346:Subarachnoid Space / Q000473:pathology
D005293:Ferritins
Kernspintomographische Befunde bei der Zwangserkrankung.