[Chronology of regression of hypertensive ventricular hypertrophy during antihypertensive therapy with beta blockers].
To define the time course of regression of left ventricular hypertrophy (LVH) during antihypertensive therapy with beta-blocking agents, 73 hypertensive patients were serially studied by echocardiography during 12-months therapy with beta-blockers. Blood pressure decreased significantly after 1 month and further on after 12 months (from 164 +/- 18/110 +/- 9 to 139 +/- 14/94 +/- 7 mmHg, p < 0.001). Left ventricular (LV) end-diastolic dimension increased significantly after 1 month (from 51.2 +/- 3.9 to 52.2 +/- 4.7 mm, p < 0.01) and decreased after 12 months (50.4 +/- 4.0 mm, p < 0.05). Septal and posterior wall thickness decreased progressively after 1 month and 3 months, respectively. LV mass index decreased significantly after 3 months, and further on after 12 months (from 164 +/- 42 to 145 +/- 33 g/m2, p < 0.001). LV fractional shortening did not significantly change throughout the study. Thus, a reduction of hypertensive LVH occurred after 3 months of therapy with beta-blocking agents and went on during the subsequent months without impairment of LV systolic function.
Sau
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Istituto di Cardiologia, Università degli Studi, Cagliari.
Seguro
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Pargentino
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D000070:Acebutolol / Q000008:administration & dosage; D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007192:Indenes / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010096:Oxprenolol / Q000008:administration & dosage; D010869:Pindolol / Q000008:administration & dosage; D011412:Propanolamines / Q000008:administration & dosage; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D007192:Indenes; D011412:Propanolamines; D010096:Oxprenolol; C002989:indenolol; D000070:Acebutolol; D010869:Pindolol
Cronologia della regressione dell'ipertrofia ventricolare ipertensiva durante terapia antipertensiva con betabloccanti.