Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA.
A cross-sectional study was conducted among prostitutes in Nairobi, Kenya, to determine the prevalence and correlates of cervical human immunodeficiency virus (HIV) DNA. Ninety-two HIV-seropositive prostitutes were evaluated during 137 clinic visits. Cervical HIV DNA was detected by polymerase chain reaction assay in 36 (39%) women at initial visits and in 40 (44%) women at any visit. There was a significant correlation between cervical HIV and microscopic evidence of cervical inflammation (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.1-24.6). Using multivariate analysis to adjust for possible confounding, the adjusted OR for the association between cervical inflammation and cervical HIV DNA was 8.7 (95% CI, 2.0-37.2). Conditions associated with cervical inflammation are associated with the detection of HIV proviral DNA. Whether such conditions lead to increased infectivity remains to be proven.
Kreiss
J
J
Department of Epidemiology, University of Washington, Seattle.
Willerford
D M
DM
Hensel
M
M
Emonyi
W
W
Plummer
F
F
Ndinya-Achola
J
J
Roberts
P L
PL
Hoskyn
J
J
Hillier
S
S
Kiviat
N
N
D000328:Adult; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006678:HIV / Q000302:isolation & purification* / Q000502:physiology; D006679:HIV Seropositivity / Q000821:virology*; D006801:Humans; D007630:Kenya; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000302:isolation & purification; D011477:Sex Work; D012725:Sexual Behavior; D002575:Uterine Cervicitis / Q000821:virology*; D017201:Virus Shedding
D004279:DNA, Viral