Hemorrhagic gastroesophageal ulceration by pulmonary infection in extrahepatic cholestatic pigs.
We developed a biliary and pulmonary microbiologic study in 22 Large-White pigs that underwent bile-duct ligation in order to demonstrate that sepsis has a biliary and pulmonary origin which may be involved in the gatroesophageal pathology. All the pigs died at 18.2 +/- 8.9 days of the post-operative period. The cause of death was hemorrhagic ulceration of the gastroesophageal region in 36.3% (n = 8) of the animals that also presented multiple bilateral miliary lung abscesses. High infestation rates with intestinal germs were found in the bile and lung. In conclusion, the experimental model of extrahepatic cholestasis in the Large-White pig could be useful for the study of etiopathogenic mechanisms by which the pulmonary infection produces a hemorrhagic gastroesophageal ulceration considered as stress ulcer.
Trobo
J I
JI
Experimental Medicine and Surgery Unit, Hospital Universitario San Carlos, Complutense University of Madrid, Spain.
Lorente
L
L
Aller
M A
MA
Durán
M C
MC
Betriu
C
C
Arias
J
J
D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000150:complications*; D004195:Disease Models, Animal; D004935:Esophageal Diseases / Q000209:etiology; D005260:Female; D008168:Lung / Q000382:microbiology; D008169:Lung Abscess / Q000150:complications* / Q000382:microbiology; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology*; D013276:Stomach Ulcer / Q000150:complications; D013312:Stress, Physiological / Q000209:etiology; D013552:Swine; D014456:Ulcer / Q000209:etiology