title: 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an azetidine moiety.
abstract: A series of 7-(2,3-disubstituted-1-azetidinyl)-1,4-dihydro-6-fluoro-4- oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, was prepared to study the effects on potency and physicochemical properties of the substituent at position 2 of the azetidine moiety. The activity of the title compounds was determined in vitro against Gram-positive and Gram-negative bacteria, and the in vivo efficacy of selected derivatives was determined using a mouse infection model. The X-ray crystal structures of 6b, 6c, and 6d were found to be in reasonable agreement with the corresponding AM1 calculated geometries. Correlations between antibacterial potency of all the synthesized 7-azetidinylquinolones and naphthyridines and their calculated electronic properties and experimental capacity factors were established. Antibacterial efficacy and pharmacokinetic and physicochemical properties of selected derivatives were compared to the relevant 7-(3-amino-1-azetidinyl) and 7-(3-amino-3-methyl-1-azetidinyl) analogues (for Part 1, see: J. Med. Chem. 1993, 36, 801-810). A combination of a cyclopropyl or a substituted phenyl group at N-1 and a trans-3-amino-2-methyl-1-azetidinyl group at C-7 conferred the best overall antibacterial, pharmacokinetic, and physicochemical properties to the azetidinylquinolones studied.
authors.affiliation: Department of Medicinal Chemistry, Laboratorios Dr. Esteve, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Frigola
authors.forename: A
authors.initials: A
authors.lastname: Torrens
authors.forename: J A
authors.initials: JA
authors.lastname: Castrillo
authors.forename: J
authors.initials: J
authors.lastname: Mas
authors.forename: D
authors.initials: D
authors.lastname: Vañó
authors.forename: J M
authors.initials: JM
authors.lastname: Berrocal
authors.forename: C
authors.initials: C
authors.lastname: Calvet
authors.forename: L
authors.initials: L
authors.lastname: Salgado
authors.forename: J
authors.initials: J
authors.lastname: Redondo
authors.forename: S
authors.initials: S
authors.lastname: García-Granda
mesh_terms: D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001384:Azetidines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D018360:Crystallography, X-Ray; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D001384:Azetidines