title: New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occurring in north west Bangladesh.
abstract: Neurolathyrism is a form of spastic paraparesis caused by the neuroexcitatory amino acid 3-N-oxalyl-L-2,3-diaminopropanoic acid (beta-ODAP) present in the seeds and foliage of Lathyrus sativus. The disease is irreversible and usually nonprogressive. Tolperisone HCl, a centrally acting muscle relaxant, has been shown to reduce significantly the spasticity in neurolathyrism patients. Sporadic occurrence of HTLV-1 infection (0.9%) and of osteolathyrism was found among the neurolathyrism patients. Osteolathyrism is linked to the consumption of the green shoots of Lathyrus sativus.
authors.affiliation: Department of Neurology, Institute of Postgraduate Medicine and Research, Dhaka, Bangladesh.
authors.forename: A
authors.initials: A
authors.lastname: Haque
authors.forename: M
authors.initials: M
authors.lastname: Hossain
authors.forename: J K
authors.initials: JK
authors.lastname: Khan
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: F
authors.initials: F
authors.lastname: Lambein
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
mesh_terms: D001459:Bangladesh; D001847:Bone Diseases / Q000150:complications; D015481:HTLV-I Antibodies / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007842:Lathyrism / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D016472:Motor Neuron Disease / Q000188:drug therapy* / Q000503:physiopathology; D015493:Paraparesis, Tropical Spastic / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D014049:Tolperisone / Q000627:therapeutic use*
chemical_list: D015481:HTLV-I Antibodies; D014049:Tolperisone