Eosinophils and AIDS.
Since early descriptions of Acquired Immune Deficiency Syndrome (AIDS) in the 1980s most of our research effort has been focused on a singular population, the CD4 cell population. Numerous investigations have been done into why there is a gradual diminution in CD4 counts; therapeutic interventions have focused on raising abnormally low CD4 levels. I suggest that another cell line, the eosinophil cell line, may also be abnormal in AIDS and hypothesize that an increase in eosinophil cell count and activation of eosinophils may also be important to AIDS.
Harris
P J
PJ
AIDS Clinical Research Center of Washington, DC 20009.
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000209:etiology*; D004802:Eosinophilia / Q000209:etiology; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D007958:Leukocyte Count; D008954:Models, Biological