Nitric oxide controls feeding behavior in the chicken.
To investigate the effect of nitric oxide (NO) on food intake in the chicken, L-NG-nitro-arginine methyl ester HCl (L-NNA), an inhibitor of NO synthase, was applied. When i.p. administered, L-NNA significantly inhibited the food intake of broiler chickens in a dose response manner. Food ingestion was also depressed by the i.c.v. injection of L-NNA in a dose response fashion. The effect of L-NNA was attenuated by i.c.v. administration of L-arginine. These results suggest that central NO may control feeding behavior in the chicken.
Choi
Y H
YH
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
Furuse
M
M
Okumura
J
J
Denbow
D M
DM
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D002645:Chickens; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005260:Female; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D019335:Nitroarginine
D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine