[The optimization of Capoten treatment by taking into account its chronosensitivity in hypertension patients].
The trial was made of Capoten used according to the conventional scheme (14 patients) against the drug regimen chronosensitivity-adjusted (15 patients). All the patients had essential hypertension stage II. When used at the hours of the greatest sensitivity, Capoten proved more effective this permitting lower single, daily and course doses administration, hypotensive effect occurred in shorter period of time. The effect was produced via a marked fall in peripheral vascular resistance.
Zaslavskaia
R M
RM
Akhmetov
K Zh
KZh
Hulberg
F
F
Teiblum
M M
MM
D000328:Adult; D000368:Aged; D002216:Captopril / Q000008:administration & dosage* / Q000494:pharmacology; D002909:Chronobiology Phenomena / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002216:Captopril
Optimizatsiia lecheniia kapotenom s uchetom khronochuvstvitel'nosti k nemu bol'nykh gipertonicheskoĭ bolezn'iu.