Presynaptic inhibition by neuropeptide Y of slow inhibitory synaptic transmission in submucous neurones of guinea-pig caecum.
The occurrence and disposition of immunoreactivity for neuropeptide Y (NPY) was investigated in the submucosa of guinea-pig caecum. There were few NPY-immunoreactive neurones but intraganglionic varicose fibres were so numerous and strongly immunoreactive that some somata may have been obscured. In each neurone tested, exogenous application of NPY (1-100 nM) depressed the duration and amplitude of the slow inhibitory postsynaptic potential. In contrast, NPY (1-300 nM) had no effects on the resting membrane potential, input resistance and fast and slow excitatory synaptic transmission.
Cunningham
S M
SM
Department of Biomedical Sciences, University of Aberdeen, Marischal College.
Mihara
S
S
Lees
G M
GM
D000818:Animals; D002432:Cecum / Q000294:innervation*; D004594:Electrophysiology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009478:Neuropeptide Y / Q000494:pharmacology*; D017729:Presynaptic Terminals / Q000187:drug effects*; D013368:Submucous Plexus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D009478:Neuropeptide Y