title: Efficient phosphate binding using a combination of gluconolactate and carbonate calcium salts.
abstract: Although renal-failure-related hyperphosphataemia can be corrected by various phosphate binders, there remains a need for safer and more efficient formulations to precipitate phosphate. This work describes both a theoretical approach and a phosphate precipitation test in order to design efficient binding calcium salts formulations. The results show that the combination of a soluble calcium salt (the gluconolactate) and a proton-consuming calcium salt (the carbonate) can precipitate phosphate effectively. Furthermore, the theoretical computations correlate well with the ability of the salt to bind phosphate in vitro.
authors.affiliation: Pharmacie Centrale des Hôpitaux de Paris, France.
authors.forename: J Y
authors.initials: JY
authors.lastname: Legendre
authors.forename: S
authors.initials: S
authors.lastname: Cote
authors.forename: D
authors.initials: D
authors.lastname: Pradeau
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: C
authors.initials: C
authors.lastname: Vitzling
authors.forename: D
authors.initials: D
authors.lastname: Lavene
authors.forename: A
authors.initials: A
authors.lastname: Tarral
mesh_terms: D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D002119:Calcium Carbonate / Q000378:metabolism*; D002125:Calcium Gluconate / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D010710:Phosphates / Q000378:metabolism*; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications / Q000378:metabolism; D013054:Spectrophotometry, Atomic
chemical_list: D000085:Acetates; D010710:Phosphates; D002119:Calcium Carbonate; D019342:Acetic Acid; D002125:Calcium Gluconate