Effect of des-tyrosine-gamma-endorphin on neocortical spike-and-wave spindling in DBA/2J mice.
The effect of a beta-endorphin cleavage product devoid of opioid effects, des-tyrosine-gamma-endorphin (DT gamma E) on the neocortical spike-and-wave spindling episodes in the electrocorticogram (ECoG) of DBA/2J mice was studied. DT gamma E (0.01-1.0 mg/kg, i.p.) dose dependently reduced the spike-and-wave bursts duration. However, the low dose did not induce consistent modifications of the spike-and-wave bursts number while the dose of 0.1 and 1.0 mg/kg induced a progressive diminution. Furthermore, at all doses DT gamma E did not induce any alterations of the spike-and-wave bursts amplitude, frequency, and desynchronized activity when compared to the pre-drug period. These results indicate that this beta-endorphin fragment may affect brain excitability.
Capasso
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School of Pharmacy, University of Salerno, Italy.
Sorrentino
L
L
Di Giannuario
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A
Pieretti
S
S
Loizzo
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A
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004723:Endorphins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010446:Peptide Fragments / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D000928:Antidepressive Agents; D004723:Endorphins; D010446:Peptide Fragments; C018903:gamma-endorphin, des-Tyr(1)-