title: Functional magnetic resonance imaging in partial epilepsy.
abstract: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: G L
authors.initials: GL
authors.lastname: Morris
authors.forename: W M
authors.initials: WM
authors.lastname: Mueller
authors.forename: F Z
authors.initials: FZ
authors.lastname: Yetkin
authors.forename: V M
authors.initials: VM
authors.lastname: Haughton
authors.forename: T A
authors.initials: TA
authors.lastname: Hammeke
authors.forename: S
authors.initials: S
authors.lastname: Swanson
authors.forename: S M
authors.initials: SM
authors.lastname: Rao
authors.forename: A
authors.initials: A
authors.lastname: Jesmanowicz
authors.forename: L D
authors.initials: LD
authors.lastname: Estkowski
authors.forename: P A
authors.initials: PA
authors.lastname: Bandettini
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005385:Fingers / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008046:Lip / Q000502:physiology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods; D009048:Motor Skills / Q000502:physiology; D009068:Movement / Q000502:physiology; D010865:Pilot Projects; D014059:Tongue / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin