[The effect of calcium antagonists and beta-adrenoblockaders on disordered stomach functions in patients with duodenal peptic ulcer].
The effect of a single dose of nifedipine or propranolol hydrochloride on gastric acid production and motility has been assessed in 90 duodenal ulcer (DU) patients having the relapse. Intragastric pH-metry showed that the drugs in a dose 20 mg significantly inhibit basal acid production. As indicated by electrogastromyography, nifedipine effect on gastric motility depends on its baseline level. The drug displays a moderate normalizing action (modulating effect) on the dominating frequency, amplitude of motor oscillations and overall capacity of gastric biopotentials. Propranolol hydrochloride noticeably lowered initially high frequency of gastric contractions. Due to nifedipine gastric evacuation inhibits and makes more regular. The authors recommend introduction of nifedipine and propranolol hydrochloride in correction of gastric dysfunction in DU patients.
Tsimmerman
Ia S
IaS
Budnik
Iu B
IuB
Syman
L N
LN
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005745:Gastric Acidity Determination; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D012008:Recurrence; D013270:Stomach / Q000187:drug effects* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D011433:Propranolol; D009543:Nifedipine
Vliianie antagonistov kal'tsiia i beta-adrenoblokatorov na narushennye funktsii zheludka u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.