A single clonal abnormality of chromosome 1 found in an adenocarcinoma of the uterus.
Adenocarcinomas usually have a complex genome comprised of multiple chromosomal alterations. These neoplasms rarely express a single genomic change. We report the first case of an endometrial adenocarcinoma demonstrating a single genomic variation in chromosome 1 associated with a 2 1/2-year survival. The finding of this anomaly may be important in determining the etiology and clinical behavior of uterine malignancies.
Deger
R B
RB
Crozer-Chester Medical Center, Ambulatory Care Pavilion, Upland, PA 19013.
Noumoff
J S
JS
Faruqi
S A
SA
D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002999:Clone Cells; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D014314:Trisomy