title: Tocolysis for recurrent preterm labor using a continuous subcutaneous infusion pump.
abstract: This study attempted to determine the best method of treatment for patients with recurrent preterm labor: administration of terbutaline via an automated, programmable, subcutaneous infusion pump or oral terbutaline. In this retrospective, controlled study, 32 patients diagnosed with recurrent preterm labor, as determined by persistent uterine contractions with cervical change, were treated with a programmable infusion pump adjusted to control uterine contraction frequency to < or = 4 contractions per hour. Patients in this group were matched for age, race, parity, gestational age and cervical dilation at diagnosis of recurrent preterm labor in subjects taking oral terbutaline. The patients receiving oral terbutaline were given an average of 6.5 mg every four to six hours to maintain uterine quiescence, while those in the pump group were given basal rates of terbutaline and in addition received four to six boluses per day (< 3 mg/d total dose) to achieve this outcome. Patients using the pump were more likely to reach term and less likely to fail tocolytic therapy than were those taking oral terbutaline. The terbutaline pump appeared to be more successful in prolonging pregnancies to term after the diagnosis of recurrent preterm labor than did oral terbutaline.
authors.affiliation: Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
authors.forename: J R
authors.initials: JR
authors.lastname: Allbert
authors.forename: C
authors.initials: C
authors.lastname: Johnson
authors.forename: W E
authors.initials: WE
authors.lastname: Roberts
authors.forename: R W
authors.initials: RW
authors.lastname: Martin
authors.forename: K S
authors.initials: KS
authors.lastname: Gookin
authors.forename: J C
authors.initials: JC
authors.lastname: Morrison
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004360:Drug Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D005260:Female; D018718:Home Infusion Therapy / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007260:Infusion Pumps; D007263:Infusions, Parenteral; D016555:Matched-Pair Analysis; D007752:Obstetric Labor, Premature / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012008:Recurrence; D012189:Retrospective Studies; D013726:Terbutaline / Q000627:therapeutic use*; D015145:Tocolysis / Q000295:instrumentation* / Q000379:methods
chemical_list: D013726:Terbutaline