title: [An experimental infection in lambs by the hepatitis E virus].
abstract: Lambs were experimentally infected with a pool of 10% hepatitis E (HE) patient fecal suspension containing HE virus (HEV) isolates Osh-225 and Osh-228 which caused an infection closely resembling experimental HE in primates. Clinical manifestations consisted of acute biochemical and histological hepatitis, virus shedding in feces, the presence of virus-like particles in the peripharyngeal lymph nodes and the contents of small intestine, of HEV RNA in the parenchymal organs of lambs. Susceptibility of lambs to HEV derived from the infected piglets and the possibility of passaging the piglets' HEV in lambs was demonstrated. This passaging led to shortening of the incubation period.
authors.forename: R K
authors.initials: RK
authors.lastname: Usmanov
authors.forename: M S
authors.initials: MS
authors.lastname: Balaian
authors.forename: O V
authors.initials: OV
authors.lastname: Dvoĭnikova
authors.forename: D B
authors.initials: DB
authors.lastname: Alymbaeva
authors.forename: N A
authors.initials: NA
authors.lastname: Zamiatina
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kazachkov
authors.forename: V I
authors.initials: VI
authors.lastname: Belov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005243:Feces / Q000737:chemistry / Q000821:virology; D016751:Hepatitis E / Q000201:enzymology / Q000382:microbiology* / Q000473:pathology; D016752:Hepatitis E virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D008099:Liver / Q000382:microbiology / Q000648:ultrastructure; D012367:RNA, Viral / Q000032:analysis; D012756:Sheep; D012757:Sheep Diseases / Q000201:enzymology / Q000382:microbiology* / Q000473:pathology; D013997:Time Factors; D000637:Transaminases / Q000097:blood
chemical_list: D012367:RNA, Viral; D000637:Transaminases
vernacular_title: Eksperimental'naia infektsiia iagniat virusom gepatita E.