The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate.
The effect of the thiazide diuretic, bemetizide, on the excretion of Na+, K+, Cl-, Ca2+, and Mg2+ in relation to the glomerular filtration rate (GFR) was studied in 17 subjects whose creatinine clearances ranged from 133 to 5 ml.min-1. After a 2-day fluid and salt balanced control period, 25 mg bemetizide given orally induced natriuresis and kaliuresis which lasted for 24 h and were proportional to the GFR of the patients. The ratio of bemetizide-induced K+/Na+ excretion was always 0.17 irrespective of individual GFR. In renal failure, bemetizide increased the fractional Na+ excretion from 3% to about 10%. Kaliuresis was associated with magnesiuria, whereas bemetizide-induced calciuresis was insignificant. The thiazide reversibly lowered GFR in all subjects.
Knauf
H
H
Medizinische Klinik I, St. Bernward-Krankenhaus, Hildesheim, Germany.
Cawello
W
W
Schmidt
G
G
Mutschler
E
E
D000328:Adult; D000368:Aged; D001581:Benzothiadiazines / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics; D004573:Electrolytes / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000652:urine; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*
D001581:Benzothiadiazines; D004232:Diuretics; D004573:Electrolytes; D049993:Sodium Chloride Symporter Inhibitors; C010100:dehydrosanol