Alterations in plasma total and high density lipoprotein cholesterol levels in hyperlipidemic rats fed diets with varied content of selenium and vitamin E.
The effect of dietary selenium and vitamin E on plasma total (TC) and high density lipoprotein cholesterol (HDLC) was evaluated in 54 Sprague Dawley rats fed cholesterol/cholic acid enriched diets. Diets 1, 2, and 3 had no added selenium (low Se) and 0 (low), 60 (adequate), and 600 (high) mg/kg dL alpha tocopheryl acetate added respectively. Sodium selenite at 0.2 mg/kg (adequate Se) was added to diets 4, 5, and 6 and at 4.0 mg/kg (toxic Se) to diet 7, 8, and 9 with the same pattern of vitamin E added to the diet as described above. TC and HDLC were measured using the Kodak Ectachem system. Rats in the low and adequate Se groups fed high vitamin E had lower TC values than rats fed lower vitamin E levels but differences were not significant. In the toxic Se groups, rats fed high vitamin E had significantly (p < 0.05) higher plasma TC values than did lower Vitamin E groups. Rats on the high vitamin E diets with low or adequate Se had significantly (p < 0.05) higher mean plasma HDLC values when compared to rats fed low or adequate vitamin E diets. HDLC values for animals on Se toxic diets were significantly (p < 0.05) lower in rats fed a low vitamin E diet. In rats fed Se deficient and adequate diets, a high vitamin E intake resulted in a decrease in TC and an increase in HDLC.(ABSTRACT TRUNCATED AT 250 WORDS)
Liu
W
W
Department of Education, Nutrition, Restaurant/Hotel Management, Texas Tech University, Lubbock 79409.
Boylan
L M
LM
D000704:Analysis of Variance; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL / Q000097:blood*; D019826:Cholic Acid; D002793:Cholic Acids / Q000008:administration & dosage; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000378:metabolism; D006949:Hyperlipidemias / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood* / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D002793:Cholic Acids; D008075:Lipoproteins, HDL; D014810:Vitamin E; D002784:Cholesterol; D005979:Glutathione Peroxidase; D019826:Cholic Acid; D012643:Selenium