title: [Changes in the composition and properties of the joint contents in hemophilic arthropathies during local invasive therapy].
abstract: An immunological study has been made in 47 hemophiliacs with arthropathies receiving local invasive therapy. Joint contents were examined in 20 patients with acute hemarthrosis, 10 patients with exudative synovitis and 11 ones with proliferative synovitis. Under the protection of cryoprecipitate (5 U/kg) all the patients underwent joint puncture with removal of the contents, lavage of the synovial cavity and intraarticular injection of 50 mg of hydrocortisone. Arthropathy activity proved most active in patients with proliferative synovitis. Introduction of local invasive therapy early in hemarthrosis course arrests immune inflammation. Delayed punctures are less effective. Local immunological responses, as shown by repeated punctures, noticeably reduced, at puncture 3-4 the contents were small, immune complexes and immunoglobulins decreased significantly.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Barkagan
authors.forename: A V
authors.initials: AV
authors.lastname: Chantsev
authors.forename: V V
authors.initials: VV
authors.lastname: Usynin
authors.forename: L A
authors.initials: LA
authors.lastname: Liashenko
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006395:Hemarthrosis / Q000209:etiology / Q000276:immunology* / Q000628:therapy*; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology / Q000628:therapy; D002836:Hemophilia B / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007270:Injections, Intra-Articular; D011677:Punctures; D012008:Recurrence; D013396:Suction; D013582:Synovial Fluid / Q000166:cytology* / Q000276:immunology; D007507:Therapeutic Irrigation; D014783:Viscosity
chemical_list: D006854:Hydrocortisone
vernacular_title: Izmenenie sostava i svoĭstv sustavnogo soderzhimogo pri gemofilicheskikh atropatiiakh v protsesse lokal'noĭ invazivnoĭ terapii.