Solid state investigation of mefloquine hydrochloride.
Mefloquine hydrochloride was crystallized under different conditions and the products were studied by thermal analysis, IR spectroscopy and X-ray diffraction. It was demonstrated that different conditions of crystallization resulted in different crystal structures. The alpha- and delta-modifications were hydrates, the beta- and gamma-forms were polymorphs, the epsilon-form was an acetone solvate and theta-mefloquine was tetrahydrofuran solvate. During long storage at room temperature, the alpha-, delta- and theta-forms of mefloquine hydrochloride were transformed. By heat treatment of the delta-, epsilon and theta-modifications, a new crystal structure was obtained.
Kiss
A
A
Alkaloida Chemical Company Ltd, Tiszavasvári, Hungary.
Répási
J
J
Salamon
Z
Z
Novák
C
C
Pokol
G
G
Tomor
K
K
D002152:Calorimetry, Differential Scanning; D002849:Chromatography, Gas; D018360:Crystallography, X-Ray; D004055:Differential Thermal Analysis; D015767:Mefloquine / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry
D015767:Mefloquine