title: Primary head and neck cancer. Histopathologic predictors of recurrence after neck dissection in patients with lymph node involvement.
abstract: OBJECTIVE
  Retrospectively analyze several histopathologic variables that may predict neck recurrence after neck dissection.
  
  
  METHODS
  From 1970 through 1980, 284 patients with pathologically confirmed metastatic squamous cell carcinoma underwent neck dissection and received no adjuvant therapy. Kaplan-Meier evaluation estimated a 74% 2-year neck recurrence-free rate. After adjusting for the standard covariates of age, gender, neck stage, and tumor grade, we also controlled for the time-dependent covariates of primary recurrence, occurrence in the side of the neck not operated on, or development of new head and neck primary disease.
  
  
  METHODS
  A large referral-based practice.
  
  
  RESULTS
  The number of lymph nodes involved, invasion of vascular/lymphatic space, invasion of soft tissue, and desmoplastic lymph node pattern adversely affect neck recurrence. A desmoplastic stromal pattern was associated with almost a sevenfold increased risk of neck recurrence. To our knowledge, this finding has not been reported previously.
  
  
  CONCLUSIONS
  Histopathologic evaluation of metastatically involved cervical nodes can identify patients with head and neck cancer who are at high risk for recurrence.
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minn.
authors.forename: K D
authors.initials: KD
authors.lastname: Olsen
authors.forename: M
authors.initials: M
authors.lastname: Caruso
authors.forename: R L
authors.initials: RL
authors.lastname: Foote
authors.forename: R J
authors.initials: RJ
authors.lastname: Stanley
authors.forename: J E
authors.initials: JE
authors.lastname: Lewis
authors.forename: S J
authors.initials: SJ
authors.lastname: Buskirk
authors.forename: D A
authors.initials: DA
authors.lastname: Frassica
authors.forename: L W
authors.initials: LW
authors.lastname: DeSanto
authors.forename: W M
authors.initials: WM
authors.lastname: O'Fallon
authors.forename: V R
authors.initials: VR
authors.lastname: Hoverman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis