Interactions between DNA replication-related proteins and phospholipid vesicles in vitro.
DNA and phospholipids share a common motif recognizable by proteins. It has been my hypothesis that there are DNA binding proteins which interact with phospholipid membranes and that their activities in DNA replication, transcription, and recombination, are likely to be regulated by phospholipids. I describe here examples of replication-related proteins, the activities of which are modified by acidic phospholipids in vitro.
Sekimizu
K
K
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
D000952:Antigens, Polyomavirus Transforming / Q000737:chemistry* / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D002308:Cardiolipins / Q000737:chemistry*; D002746:Chlorpromazine / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D004261:DNA Replication; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D006367:HeLa Cells; D006657:Histones / Q000378:metabolism; D006801:Humans; D008081:Liposomes; D010741:Phospholipases A / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013539:Simian virus 40 / Q000378:metabolism
D000952:Antigens, Polyomavirus Transforming; D001426:Bacterial Proteins; D002308:Cardiolipins; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria; D006657:Histones; D008081:Liposomes; D010743:Phospholipids; D004247:DNA; D010741:Phospholipases A; D004264:DNA Topoisomerases, Type I; D002746:Chlorpromazine