Renal microangiopathy in the primary antiphospholipid syndrome: a case report with literature review.
We report the case of a 52-year-old male patient with recurrent thrombosis from 'primary antiphospholipid syndrome' who developed renal microangiopathy. Despite anticoagulant therapy with coumadin, serum creatinine progressively increased from 398 to 592 mumol/l and platelets decreased to 43,000. The patient responded to high-dose methylprednisolone and aspirin and the renal function improved. A review of the literature disclosed 4 other cases of association between primary antiphospholipid syndrome and renal microangiopathy. The clinical characteristics of these cases are discussed.
Domrongkitchaiporn
S
S
Department of Medicine, Vancouver General Hospital, Canada.
Cameron
E C
EC
Jetha
N
N
Kassen
B O
BO
Sutton
R A
RA
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D012077:Renal Artery; D013927:Thrombosis / Q000209:etiology*