[Assessment of genotoxic activity of azo dye thiadiazole derivatives with the help of a structural chromosome aberration test].
The genotoxic activity of 2-methyl aminothiadiazole and azo dyes series of azo thiadiazole-1,3,4 was assessed using chromosome aberration in vivo and in vitro. The test in vivo was performed on mice bone marrow cells and in vitro on human blood lymphocytes. Derivatives of 2-naphthol, p-chlorophenol, pyro-catechin, resorcin and gamma resorcin acid were tested. The study did not reveal any toxic effect of azo dies in doses used in the test. Their use in the synthesis of more complex substances can be recommended.
Kalski
A
A
Zakładu Ochrony Radiologicznej i Toksykologii, Wojskowej Akademii Medycznej, Lodzi.
Strózyński
H
H
Smok
W
W
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests
D001391:Azo Compounds
Ocena właściwości genotoksycznych barwników azowych pochodnych tiadiazolu za pomoca testu aberracji chromosomowych strukturalnych.