title: Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes.
authors.affiliation: Wistar Institute, Philadelphia, PA.
authors.forename: G
authors.initials: G
authors.lastname: Trinchieri
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003001:Cloning, Molecular; D016207:Cytokines / Q000096:biosynthesis; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D015658:HIV Infections / Q000503:physiopathology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007239:Infections / Q000503:physiopathology / Q000628:therapy; D018664:Interleukin-12 / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D011487:Protein Conformation; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism; D053707:Receptors, Interleukin-12; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12; D018664:Interleukin-12