Efficient phosphate binding using a combination of gluconolactate and carbonate calcium salts.
Although renal-failure-related hyperphosphataemia can be corrected by various phosphate binders, there remains a need for safer and more efficient formulations to precipitate phosphate. This work describes both a theoretical approach and a phosphate precipitation test in order to design efficient binding calcium salts formulations. The results show that the combination of a soluble calcium salt (the gluconolactate) and a proton-consuming calcium salt (the carbonate) can precipitate phosphate effectively. Furthermore, the theoretical computations correlate well with the ability of the salt to bind phosphate in vitro.
Legendre
J Y
JY
Pharmacie Centrale des Hôpitaux de Paris, France.
Cote
S
S
Pradeau
D
D
Hamon
M
M
Vitzling
C
C
Lavene
D
D
Tarral
A
A
D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D002119:Calcium Carbonate / Q000378:metabolism*; D002125:Calcium Gluconate / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D010710:Phosphates / Q000378:metabolism*; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications / Q000378:metabolism; D013054:Spectrophotometry, Atomic
D000085:Acetates; D010710:Phosphates; D002119:Calcium Carbonate; D019342:Acetic Acid; D002125:Calcium Gluconate