title: Isolation and characterization of new 18-membered macrolides FD-891 and FD-892.
abstract: New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture Japan. They induce morphological changes of HL-60 cells at low concentration below IC50s and have cytocidal activity against in vitro tumor cell lines. FD-891 showed 2 approximately 7 times stronger activity than doxorubicin whereas FD-892 was 20 approximately 100 fold weaker than FD-891 and doxorubicin.
authors.affiliation: Dept. of Applied Biology, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Seki-Asano
authors.forename: T
authors.initials: T
authors.lastname: Okazaki
authors.forename: M
authors.initials: M
authors.lastname: Yamagishi
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Hanada
authors.forename: K
authors.initials: K
authors.lastname: Mizoue
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D018942:Macrolides; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C091118:FD 891; C091119:FD 892; D000251:Adenosine Triphosphatases