title: Testicular seminoma presenting with features of androgen excess.
abstract: A 32-year-old white man presented with worsening acne and noticeable increase in muscle bulk. On examination, a firmer area with a granular consistency was noted in the right testis. A right radical orchiectomy was performed and the histologic findings were those of a typical seminoma associated with marked Leydig cell hyperplasia. A solitary right iliac lymph node metastasis, but not the primary seminoma, contained human chorionic gonadotrophin- (HCG) producing syncytiotrophoblast, which was regarded as the hormonal stimulus for Leydig cell hyperplasia and elevated serum testosterone. This seems to be the first report of testicular seminoma presenting with symptoms of androgen excess.
authors.affiliation: Department of Urology, St. Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: L C
authors.initials: LC
authors.lastname: Fung
authors.forename: R J
authors.initials: RJ
authors.lastname: Honey
authors.forename: G W
authors.initials: GW
authors.lastname: Gardiner
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000096:biosynthesis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018239:Seminoma / Q000175:diagnosis / Q000378:metabolism*; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D006063:Chorionic Gonadotropin; D013739:Testosterone