title: Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
authors.affiliation: Department of Neurosurgery, Childrens Hospital Los Angeles.
authors.forename: C
authors.initials: C
authors.lastname: Raffel
authors.forename: K
authors.initials: K
authors.lastname: Culver
authors.forename: D
authors.initials: D
authors.lastname: Kohn
authors.forename: M
authors.initials: M
authors.lastname: Nelson
authors.forename: S
authors.initials: S
authors.lastname: Siegel
authors.forename: F
authors.initials: F
authors.lastname: Gillis
authors.forename: C J
authors.initials: CJ
authors.lastname: Link
authors.forename: J G
authors.initials: JG
authors.lastname: Villablanca
authors.forename: W F
authors.initials: WF
authors.lastname: Anderson
mesh_terms: D000293:Adolescent; D000818:Animals; D001254:Astrocytoma / Q000188:drug therapy*; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D004351:Drug Resistance; D005240:Feasibility Studies; D005260:Female; D015774:Ganciclovir / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007258:Informed Consent; D007278:Injections, Spinal; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D012190:Retroviridae; D012306:Risk; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics*; D015173:Supratentorial Neoplasms / Q000188:drug therapy*; D013937:Thymidine Kinase / Q000235:genetics*; D014161:Transduction, Genetic
chemical_list: D013937:Thymidine Kinase; D015774:Ganciclovir