title: Elimination of antipyrine and its metabolites in interferon treated hepatitis C.
abstract: 1. To study the effect of interferon on hepatic drug metabolism in chronic hepatitis C, we examined nine patients before and at the end of 6 months of interferon treatment. 2. Routine liver function was determined together with the salivary clearance of antipyrine and the 48 h urinary excretion of the main metabolites of antipyrine: 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine before and after 6 months of interferon treatment. 3. Liver pathology, routine liver function, and antipyrine metabolism remained unchanged after patients were treated for 6 months with interferon for a histologically advanced but clinically compensated chronic hepatitis C.
authors.affiliation: Department of Medicine, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: J O
authors.initials: JO
authors.lastname: Sieck
authors.forename: A
authors.initials: A
authors.lastname: el-Yazigi
authors.forename: H
authors.initials: H
authors.lastname: Ali
authors.forename: M
authors.initials: M
authors.lastname: Døssing
authors.forename: J
authors.initials: J
authors.lastname: Saour
authors.forename: D A
authors.initials: DA
authors.lastname: Raines
authors.forename: P
authors.initials: P
authors.lastname: Ernst
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000983:Antipyrine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012529:Saudi Arabia
chemical_list: D016898:Interferon-alpha; D000983:Antipyrine