[Comparison of the effect of selected anticholinergic agents on cholinergic and noncholinergic effects of GV substances during acute poisoning in rats].
In experiments on male rats, the effect of selected cholinolytic agents (atropine, benactyzine, G 3063) in combination with the reactivator of cholinesterases HI-6 on the cholinergic and non-cholinergic effects of GV substance in the course of acute sublethal intoxication was compared. The cholinergic affects of GV substance were examined by means of the changes in the activity of cholinesterases in whole blood, the CNS, diaphragm and liver, the noncholinergic stressogenic effects by means of the changes in the level of corticosterone in plasma and the activity of tyrosine amino transferase in the liver. It follows from the changes in the activity of cholinesterases that the cholinergic effects of GV substance are least influenced by atropine, whereas benactyzine and G 3063 exert an approximately similar effect. The difference in the effect is evident especially in the 24th hour of intoxication. Similarly stressogenic effects of GV substance are least influenced by an antidotal combination of atropine and HI-6. It means that the centrally acting cholinolytic agents benactyzine and G 3063 are more advantageous for the therapy of GV substance poisonings than the peripherally acting atropine.
Kassa
J
J
Vojenská lékarská akademie JEP, Hradec Králové.
Bajgar
J
J
D000208:Acute Disease; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001535:Benactyzine / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism*; D008297:Male; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010091:Oximes; D010880:Piperidines / Q000494:pharmacology; D011041:Poisoning / Q000378:metabolism; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014444:Tyrosine Transaminase / Q000378:metabolism
D018680:Cholinergic Antagonists; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D010880:Piperidines; D011726:Pyridinium Compounds; C086875:2-dimethylaminoethyl-(dimethylamido)fluorophosphate; C090726:G 3063; D001535:Benactyzine; D001285:Atropine; D014444:Tyrosine Transaminase; D002802:Cholinesterases; C022870:asoxime chloride
Srovnání efektu vybraných anticholinergik na cholinergní a necholinergní úcinky GV látky bĕhem akutní intoxikace potkana.