[Paracetamol and other antipyretic analgesics: optimal doses in pediatrics].
Acetaminophen is a safe antipyretic therapy prescribed in children. The dosage usually applied in France ranges from 20 to 30 mg/kg/d, which is low and probably with little efficiency in many cases. From the data of the literature the optimal dosage seems to be 65 mg/kg/d using a 25 mg/kg loading dose, followed by a 12.5 mg/kg every 6 hours maintenance dose. The analgesic effect of a 15 mg/kg oral dose has been also demonstrated. Aspirin is equally effective, especially for rheumatic disorders, but its use is limited by adverse reactions. The other nonsteroidal anti-inflammatory drugs have a limited interest.
Stamm
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Service de réanimation pédiatrique, hôpital Edouard-Herriot, Lyon, France.
D000082:Acetaminophen / Q000008:administration & dosage* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005334:Fever / Q000188:drug therapy; D006801:Humans; D010146:Pain / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen
Paracétamol et autres antalgiques antipyrétiques: doses optimales en pédiatrie.