title: Biocompatible polyurethane-based hydrogel.
abstract: A polyurethane polymer developed at W. R. Grace has been evaluated for a variety of biomedical applications. The primary property of the polymer exploited for these applications is its ability to prevent protein adsorption when coated on a surface. The prepolymer consists of a trifunctional poly(ethyleneoxide-propylene oxide) triol end capped with isophorone diisocyanate. The prepolymer is reactive with water and can be converted to a hydrogel, a thin coating, or a soluble conjugate with another compound. Each category lends itself to separate biomedical applications which are described in detail. The non-toxic nature of the polymer was demonstrated in a number of systems and suggests its utility in biomedical applications.
authors.affiliation: W. R. Grace & Co.-Conn., Department of Mammalian Cell Research, Columbia, MD 21044.
authors.forename: J A
authors.initials: JA
authors.lastname: Braatz
mesh_terms: D000327:Adsorption; D000818:Animals; D000941:Antigens; D001672:Biocompatible Materials / Q000737:chemistry*; D003261:Contact Lenses; D005782:Gels; D006133:Growth Substances; D006207:Half-Life; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D017953:Isocyanates / Q000737:chemistry; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011095:Polyethylenes / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D014051:Toluene 2,4-Diisocyanate / Q000737:chemistry
chemical_list: D000941:Antigens; D001672:Biocompatible Materials; D005782:Gels; D006133:Growth Substances; D017953:Isocyanates; D011095:Polyethylenes; D011126:Polypropylenes; D011140:Polyurethanes; D011506:Proteins; D013501:Surface-Active Agents; C090708:HYPOL XP 5; D014051:Toluene 2,4-Diisocyanate; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C015301:isophorone diisocyanate; D012822:Silicon Dioxide; C078661:UCON 50-HB-5100