title: [Does intake of antihypertensive agents and sedatives explain the increasing incidence of colonic neoplasms?].
abstract: Not much attention has been given to drug use and risk of colorectal cancer. We investigated the issue in an 18-year prospective cohort study of 5249 Copenhagen males aged 40-59 years. Potential confounders included were tobacco smoking, alcohol consumption, coffee drinking, physical activity, and social class. Colon cancer was diagnosed in 51 men, rectal cancer in 42 (all adenocarcinomas). Estimated from a Cox proportional hazards regression equation, use of antihypertensive medicine was highly significantly associated with risk of colon cancer, relative risk (95% confidence limits) was 3.5 (1.6-7.5), p = 0.001. Frequent use of minor tranquillizers or sleeping pills was also associated with a highly significantly increased risk of colon cancer, relative risk was 3.2 (1.6-6.6), p = 0.002. By contrast, there was no such association with rectum cancer. We suggest that use of antihypertensive medicine and use of minor tranquillizers or sleeping pills may be strong risk factors for colon cancer, and that their use may contribute substantially to explaining the increased incidence of colon cancer since 1945.
authors.affiliation: Rigshospitalet, København.
authors.forename: P
authors.initials: P
authors.lastname: Suadicani
authors.forename: H O
authors.initials: HO
authors.lastname: Hein
authors.forename: F
authors.initials: F
authors.lastname: Gyntelberg
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000453:epidemiology; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D006993:Hypnotics and Sedatives
vernacular_title: Forklarer indtagelse af antihypertensiva og sedativa den øgede incidens af coloncancer?