title: Safety of the attenuated anticoccidial vaccine 'Paracox' in broiler chickens isolated from extraneous coccidial infection.
abstract: A trial was carried out in 1-day-old broiler chicks raised for 54 days in floorpens under simulated commercial conditions, but isolated from all extraneous virulent coccidial infections, to demonstrate the safety of 'Paracox' attenuated vaccine administered at the recommended dose when chicks were 7 days old. The vaccine did not adversely affect the water consumption, faecal moisture or litter condition of the broilers. Recycling of the attenuated coccidia occurred in vaccinated birds, oocysts being present in the litter between 5 and 33 days after vaccination; a single peak of oocysts was detectable 5 or 12 days after vaccination. Unvaccinated medicated control birds did not produce oocysts, indicating freedom from both between-pen contamination by the vaccine and invasion of the chicken-house by extraneous coccidial infection. A small proportion (4%) of vaccinated birds had mild coccidial lesions when sampled at 26, 33 or 40 days after vaccination. Despite this, the vaccinated birds performed better than control (unvaccinated, nicarbazin-treated) birds and there was no post-vaccinal check in their weight gain. Their mean finishing weight was 10.4% greater, their food conversion ratio 7.2% lower and their mortality 44.4% lower than the unvaccinated control birds, reflecting the safety of 'Paracox' vaccine.
authors.affiliation: Coccidiosis Section, Pitman-Moore Europe, Harefield, Uxbridge, UK.
authors.forename: R B
authors.initials: RB
authors.lastname: Williams
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D002645:Chickens / Q000502:physiology; D003044:Coccidia / Q000276:immunology* / Q000302:isolation & purification; D003048:Coccidiosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000469:parasitology / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated