Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice.
s.c. and abdominal tumors from interspecific hybrid, transgenic mice containing the SV40 early region linked to a renin enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions involved in tumorigenesis. A very high frequency of loss of heterozygosity/partial loss of heterozygosity or allelic imbalance involving the distal regions of chromosome 8 was observed in the s.c. tumors (76%) with frequent amplification (3-6 times) of the corresponding proximal regions including Junb, suggesting that chromosome 8 breakage and amplification promotes tumorigenesis in these mice.
Held
W A
WA
Roswell Park Cancer Institute, Department of Molecular and Cellular Biology, Buffalo, New York 14263.
O'Brien
J G
JG
Kerns
K
K
Gallagher
J F
JF
Sigmund
C D
CD
Gross
K W
KW
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D002872:Chromosome Deletion; D005260:Female; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000235:genetics*
D000952:Antigens, Polyomavirus Transforming; D012083:Renin