title: Bone marrow transplantation in Gaucher's disease: effect of mixed chimeric state.
abstract: The effective dose and schedule of enzyme replacement therapy for Gaucher's disease have not been definitely established. We report a case of mixed chimeric state in an allogeneic BMT patient and followed her clinical and laboratory progress. The result shows that a low but sustained glucocerebrosidase level may provide symptomatic relief for this lysosomal disorder.
authors.affiliation: Department of Paediatrics, B.C.'s Children's Hospital, Vancouver, Canada.
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: L T
authors.initials: LT
authors.lastname: Wong
authors.forename: D
authors.initials: D
authors.lastname: Applegarth
authors.forename: A G
authors.initials: AG
authors.lastname: Davidson
mesh_terms: D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002678:Chimera; D005260:Female; D005776:Gaucher Disease / Q000201:enzymology / Q000628:therapy*; D005962:Glucosylceramidase / Q000378:metabolism*; D006801:Humans; D014184:Transplantation, Homologous; D001617:beta-Glucosidase / Q000097:blood
chemical_list: D001617:beta-Glucosidase; D005962:Glucosylceramidase