title: Astrocytes as rapid sensors of peripheral axotomy in the facial nucleus of rats.
abstract: Facial nerve transection leads to functional and structural reactions in lesioned motor neurones and surrounding glial cells. Data from this study provide evidence that the most rapid reaction described so far consists of an increase in immunoreactivity of connexin-43 (cx-43), the predominant gap junction protein in astrocytes. The ipsilateral facial nucleus is selectively marked as early as 0.75 to 1.5 hours after axotomy, while the unlesioned side as well as the unoperated controls remain faintly stained. Thus, enhanced coupling capacity of astrocytes by gap junctions appears to be a sensitive indicator of modified neuronal-glial interaction in the CNS.
authors.affiliation: Department of Anatomy, University of Göttingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Rohlmann
authors.forename: R
authors.initials: R
authors.lastname: Laskawi
authors.forename: A
authors.initials: A
authors.lastname: Hofer
authors.forename: R
authors.initials: R
authors.lastname: Dermietzel
authors.forename: J R
authors.initials: JR
authors.lastname: Wolff
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology*; D001369:Axons / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D018031:Connexin 43 / Q000032:analysis*; D005154:Facial Nerve / Q000737:chemistry / Q000502:physiology*; D009046:Motor Neurons / Q000166:cytology; D009457:Neuroglia / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D018031:Connexin 43