Enzymic and permeability activity of Pseudomonas aeruginosa after treatment with sub-MICs of organic ammonium salts.
The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of 12 organic ammonium salts of A (hard-alkyltrimethylammonium bromides) and B (soft--2-(dodecanoylamino)ethylalkyldimethylammonium bromides) homologous series on phospholipase C, proteinase, elastase and permeability activity were studied. The substances with longer substituents were more effective in reducing phospholipase C activity (hard and soft series) as well as proteinase (hard series). Phospholipase C was the most frequently and the most markedly inhibited enzyme. The organic ammonium salts were less effective in inhibiting elastase and permeability activity. Only one of the substances under study reduced all the tested activities.
Hostacká
A
A
Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
Majtán
V
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002199:Capillary Permeability; D008826:Microbial Sensitivity Tests; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000472:pathogenicity; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors; D014774:Virulence
D000900:Anti-Bacterial Agents; D011480:Protease Inhibitors; D000644:Quaternary Ammonium Compounds; D010738:Type C Phospholipases; D010196:Pancreatic Elastase