Rewarding properties of non-competitive and competitive NMDA antagonists as measured by place preference conditioning in rats.
The conditioned place preference paradigm was used to evaluate rewarding properties of non-competitive (MK-801) and competitive (CGP 37849) antagonists of NMDA receptors. Both MK-801 (0.3 mg/kg ip) and CGP 37849 (5, 10, 20 mg/kg ip), administered in association with the initially non-preferred (white) side of the two-arms chamber, caused a significant increase in the time spent on that side in a post-conditioning test. These results show that both non-competitive and competitive antagonists of NMDA receptors are rewarding in animals and may therefore have an abuse potential in humans.
Papp
M
M
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Moryl
E
E
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012201:Reward
D016194:Receptors, N-Methyl-D-Aspartate; C064539:2-amino-4-methyl-5-phosphono-3-pentenoic acid; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate