Feto-maternal alloimmune thrombocytopenia associated with anti-HPA-5a--the first Australian case.
Maternal alloantibodies to platelet specific antigens are a rare but important cause of severe thrombocytopenia in the fetus and neonate. Feto-Maternal Alloimmune Thrombocytopenia (FMAT) is most often due to anti-HPA-1a (PLA-1) or anti-HPA-5b (Bra). Anti-HPA-5a (Brb) however is extremely uncommon, with only 4 cases previously described. We report the first Australian case of feto-maternal alloimmune thrombocytopenia due to anti-HPA-5a.
Roper
T S
TS
Department of Pathology, King Edward Memorial Hospital for Women.
Lown
J A
JA
Barr
A L
AL
D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D001315:Australia; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology*; D011247:Pregnancy; D013921:Thrombocytopenia / Q000276:immunology*
C071092:5a alloantigen, human; D016824:Antigens, Human Platelet