[Occupational risk factors for pharyngeal cancer. Results of the Heidelberg Pharyngeal Cancer Study].
We carried out a case-control study on the role of occupational factors on the risk of pharyngeal cancer. The study was performed at the Department of Otorhinolaryngology/Head and Neck Surgery of the University of Heidelberg and comprised 105 male patients with squamous cell carcinoma of the oropharynx and/or hypopharynx and 420 randomly selected control subjects who were matched for age, sex and residential area (1:4 matching design). The study showed that 34.3% of the cancer patients and 10.1% of the control subjects worked in the construction industry. As construction workers were 26.7% of the cancer patients and 7.1% of the control subjects employed, the relative risk of pharyngeal cancer in construction workers was estimated to be 2.5 (C.I. 1.1-5.5, adjusted for alcohol and tobacco consumption). After further adjustment for alcohol and tobacco consumption, an increased risk of pharyngeal cancer was found for workers exposed to cutting oils (RR = 3.7; C.I. 1.2-11.8), iron dust (RR = 2.7; C.I. 1.0-7.0) asbestos cement (RR = 2.5; C.I. 1.0-6.1), cement (RR = 2.2; C.I. 0.9-5.2) and coal/tar products (RR = 3.6; C.I. 0.8-17.3).
Maier
H
H
Universitäts-HNO-Klinik Heidelberg.
Fischer
G
G
Sennewald
E
E
Heller
W D
WD
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004391:Dust / Q000009:adverse effects; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations / Q000706:statistics & numerical data; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology
D004391:Dust
Berufliche Risikofaktoren für Rachenkrebs. Ergebnisse der Heidelberger Rachenkrebsstudie.