Tricuspid atresia and annular hypoplasia: report of a familial occurrence.
Occurrence of a similar cardiac malformation in multiple family members has been reported for many lesions. Neither tricuspid atresia nor tricuspid annular hypoplasia and tricuspid atresia has been described in multiple members of the same family. We report two cases of tricuspid atresia and one case of tricuspid annular hypoplasia with an atrial septal defect in siblings. The findings in this family suggest an autosomal recessive pattern of inheritance for abnormal tricuspid valve morphogenesis.
Kumar
A
A
Division of Pediatric Cardiology, University of Florida College of Medicine, Gainesville.
Victorica
B E
BE
Gessner
I H
IH
Alexander
J A
JA
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005260:Female; D005500:Follow-Up Studies; D005808:Genes, Recessive; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D018785:Tricuspid Atresia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014261:Tricuspid Valve / Q000002:abnormalities* / Q000473:pathology