C3 nephritic factor and SLE: report of four cases and review of the literature.
We present four patients with C3 nephritic factor associated with partial lipodystrophy and/or mesangiocapillary glomerulonephritis type II. Each of these patients subsequently developed features of SLE, with an onset between 2 and 24 years after the development of the lipodystrophy or glomerulonephritis. All four patients had antinuclear antibodies and three of the four had anti-Ro antibodies. These patients bring to six the number of reported cases of this association. Possible explanations for the link between these two conditions are discussed.
Walport
M J
MJ
Department of Medicine, RPMS, Hammersmith Hospital, London, UK.
Davies
K A
KA
Botto
M
M
Naughton
M A
MA
Isenberg
D A
DA
Biasi
D
D
Powell
R J
RJ
Cheung
N T
NT
Struthers
G R
GR
D000328:Adult; D003178:Complement C3 Nephritic Factor / Q000378:metabolism*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications*; D006801:Humans; D008060:Lipodystrophy / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008297:Male
D003178:Complement C3 Nephritic Factor