Acetic acid intoxication by rectal administration.
The enhanced toxicity of acid instilled directly into the rectum, without benefit of dilution and neutralization in the upper intestine, is evident in a case of acetic acid intoxication by accidental rectal administration of 50 mL of 9% acetic acid to a 5-year-old boy. The complications included necrosis of the colon, acute renal failure, acute liver dysfunction, disseminated intravascular coagulopathy (DIC) and sepsis.
Kawamata
M
M
Department of Anesthesiology, Sapporo Medical University, School of Medicine, Japan.
Fujita
S
S
Mayumi
T
T
Sumita
S
S
Omote
K
K
Namiki
A
A
D000085:Acetates / Q000008:administration & dosage / Q000506:poisoning*; D019342:Acetic Acid; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology; D000285:Administration, Rectal; D056486:Chemical and Drug Induced Liver Injury; D002675:Child, Preschool; D003106:Colon / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000503:physiopathology; D004733:Enema / Q000009:adverse effects*; D017583:Hemodiafiltration; D006801:Humans; D008297:Male; D008508:Medication Errors; D009336:Necrosis; D012769:Shock / Q000139:chemically induced
D000085:Acetates; D019342:Acetic Acid