A case of severe neonatal thrombocytopenia with schizencephaly associated with anti-HPA-1b and anti-HPA-2a.
We report a family with a neonate who was severely damaged by intracranial haemorrhages. These probably occurred before the 20th week of gestation. The neonate had a moderate thrombocytopenia. In the maternal serum anti-HPA-1b and anti-HPA-2a alloantibodies were detected. Third-generation assays were applied to identify the alloantibodies. No other cause for the bleeding was found. Probably the combination of anti-HPA-1b and anti-HPA-2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy.
Kuijpers
R W
RW
Department of Immunological Haematology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
van den Anker
J N
JN
Baerts
W
W
von dem Borne
A E
AE
D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology; D001921:Brain / Q000002:abnormalities*; D002543:Cerebral Hemorrhage / Q000151:congenital / Q000209:etiology* / Q000276:immunology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D005331:Fetomaternal Transfusion / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis*; D010980:Platelet Membrane Glycoproteins / Q000276:immunology; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000276:immunology; D013921:Thrombocytopenia / Q000151:congenital* / Q000276:immunology
D016824:Antigens, Human Platelet; D007518:Isoantibodies; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; C028254:von Willebrand factor receptor