Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.
Deletions and other genome rearrangements can be caused by radiation and are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (p(un)) mutation in the mouse is caused by a gene duplication and reverts to wild type by deletion of one copy. Reversion events in the mouse embryo were detected as black spots on the fur of the animals or microscopically as partially black hair in a background of colorless hair. The frequency of partially black hair was increased by x-rays at very low doses. A linear dose-response relation was found between 1 and 100 centigray.
Schiestl
R H
RH
Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115.
Khogali
F
F
Carls
N
N
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian / Q000528:radiation effects; D005260:Female; D017353:Gene Deletion; D006200:Hair Color / Q000235:genetics / Q000528:radiation effects; D008297:Male; D018811:Maternal Exposure; D008544:Melanocytes / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D005810:Multigene Family; D009152:Mutagenicity Tests; D009154:Mutation / Q000528:radiation effects*