Skin signs of systemic disease. When the problem is more than skin-deep.
The cutaneous manifestations of systemic diseases are diverse. In some cases, they are the first signs of an underlying disorder, such as Cowden's disease, dermatomyositis, and Lyme disease. Sister Mary Joseph's nodule (metastatic involvement of the umbilicus) is an ominous sign of internal malignant disease. Drug-induced skin necrosis may result from therapy with coumarin (Coumadin, Panwarfin, Sofarin) or heparin.
Holmes
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Loyola University, Chicago Stritch School of Medicine, Maywood, Illinois.
Massa
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D000008:Abdominal Neoplasms / Q000473:pathology / Q000556:secondary; D000925:Anticoagulants / Q000009:adverse effects; D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008193:Lyme Disease / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis* / Q000209:etiology*; D014472:Umbilicus
D000925:Anticoagulants