Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats.
Septal lesions disrupt septohippocampal neurotransmission and impair spatial memory. (-)-Nicotine reduces the memory deficits but has substantial side effect liabilities. Previous studies have demonstrated that ABT-418 is a novel, selective ligand for neuronal nicotinic acetylcholine receptors. In the current study, ABT-418 (0.19 and 1.9 mumol/kg, i.p.) administered before training significantly attenuated lesion-induced deficits in a spatial discrimination version of the Morris water maze. As lesion-induced learning deficits might parallel the cognitive deficits characteristic of Alzheimer's disease, these results suggest that ABT-418 may be useful in the treatment of this condition.
Decker
M W
MW
Dept. 47W, Pharmaceutical Products Division, Abbott Laboratories, IL 60064.
Curzon
P
P
Brioni
J D
JD
Arnerić
S P
SP
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D012688:Septum Pellucidum / Q000187:drug effects* / Q000502:physiology; D013028:Space Perception / Q000187:drug effects
D014151:Anti-Anxiety Agents; D007555:Isoxazoles; D011759:Pyrrolidines; D011978:Receptors, Nicotinic; C088383:3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole