[The efficacy of an antiviral factor obtained from infected chick embryo fibroblasts in an experimental herpetic infection].
Treatment of mice with an antiviral factor obtained from the culture medium of infected chick embryo fibroblasts protected them against lethal meningoencephalitis caused by herpes simplex virus. The degree of protection varied from 50 to 75% depending on the virus dose, the route of infection, and the mode of the antiviral factor application.
Gribkova
N V
NV
Andreeva
O T
OT
Votiakov
V I
VI
Khmara
M E
ME
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D002642:Chick Embryo; D016207:Cytokines / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000821:virology; D006561:Herpes Simplex / Q000628:therapy*; D007928:Lethal Dose 50; D008590:Meningoencephalitis / Q000628:therapy*; D051379:Mice; D008970:Molecular Weight; D013997:Time Factors
D000998:Antiviral Agents; D016207:Cytokines
Effektivnost' antivirusnogo faktora, poluchaemogo iz infitsirovannykh fibroblastov kurinogo émbriona, pri éksperimental'noĭ gerpeticheskoĭ infektsii.