title: Basal and ACTH-stimulated plasma aldosterone concentrations are normal or increased in dogs with trichuriasis-associated pseudohypoadrenocorticism.
abstract: We measured plasma concentrations of cortisol and aldosterone before and after administration of adrenocorticotropin (ACTH) in dogs with trichuriasis. These dogs had physical examination, historical, and serum electrolyte findings suggestive of hypoadrenocorticism; trichuriasis-associated pseudohypoadrenocorticism has been reported previously. We found normal basal and ACTH-stimulated plasma cortisol concentrations. Basal and ACTH-stimulated plasma aldosterone concentrations were normal in 2 dogs and increased in 3 dogs, suggesting that the electrolyte abnormalities seen in this clinical syndrome are not due to aldosterone deficiency.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, East Lansing, MI 48824.
authors.forename: T K
authors.initials: TK
authors.lastname: Graves
authors.forename: W D
authors.initials: WD
authors.lastname: Schall
authors.forename: K
authors.initials: K
authors.lastname: Refsal
authors.forename: R F
authors.initials: RF
authors.lastname: Nachreiner
mesh_terms: D000309:Adrenal Insufficiency / Q000097:blood / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000450:Aldosterone / Q000097:blood*; D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005243:Feces / Q000469:parasitology; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D010270:Parasite Egg Count / Q000662:veterinary; D011863:Radioimmunoassay / Q000662:veterinary; D014257:Trichuriasis / Q000097:blood / Q000662:veterinary*; D014882:Water-Electrolyte Balance
chemical_list: D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone