title: [Diagnosis of human papillomavirus infections in cervical cytology in the absence of classical signs].
abstract: "Nonclassic" cytologic signs (NCS) of infection by human papillomavirus (HPV) were analyzed in two groups of patients: A: (condylomata) 81 women with both condylomata confirmed by biopsy and a cervical smear not showing the "classic" signs of HPV infection, and B: (controls) 50 cervical smears diagnosed as negative. In group A, 96% showed nuclear hyperchromatism, 78% showed perinuclear halos, 77% showed clear cytoplasm, and 74% showed mild koilocytosis. In 89% of the condylomata cases at least four NCS were found. In the control group only three cases showed nuclear hyperchromatism; the most frequent NCS in this group was perinuclear halo (50%). The frequency in which NCS of condylomata are found in smears without the classic signs is high. Nevertheless, 11% of these showed less than four NCS; in all of them, nuclear hyperchromatism was prominent. This is the most useful NCS in the diagnosis of HPV infection.
authors.affiliation: Departamento de Anatomía Patológica, Pontificia Universidad Católica de Chile.
authors.forename: R
authors.initials: R
authors.lastname: Chuaqui
authors.forename: J
authors.initials: J
authors.lastname: Verni
mesh_terms: D000328:Adult; D003218:Condylomata Acuminata / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*; D002577:Uterine Cervical Diseases / Q000473:pathology
vernacular_title: Diagnóstico de infección por virus papiloma humano en citología cervical con ausencia de signos clásicos.