Insulin resistance in a patient with diabetes mellitus associated with Turner's syndrome.
We evaluated insulin resistance and assessed the effect of gliclazide on insulin resistance in a patient with diabetes mellitus associated with Turner's syndrome. Insulin-induced glucose metabolism markedly decreased compared with 12 healthy subjects. The insulin dose-response curve of this patient shifted to the right and down, and recovered somewhat after the administration of gliclazide. This patient had exhibited marked insulin resistance, which seemed to be caused by a defect at the receptor and/or post-receptor levels. Gliclazide reduced her insulin resistance, which suggests that this agent is suitable for treating the insulin resistance in diabetic patients with Turner's syndrome.
Kumon
Y
Y
Second Department of Internal Medicine, Kochi Medical School.
Hisatake
K
K
Suehiro
T
T
Sumiyoshi
R
R
Hashimoto
K
K
D000328:Adult; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D005260:Female; D005907:Gliclazide / Q000627:therapeutic use*; D015309:Glucose Clamp Technique; D018149:Glucose Intolerance / Q000150:complications / Q000175:diagnosis; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D013453:Sulfonylurea Compounds / Q000627:therapeutic use; D014424:Turner Syndrome / Q000150:complications*
D013453:Sulfonylurea Compounds; D005907:Gliclazide