[Effect of anti-aging drug on the activity of DNA methylase in rat liver].
An obvious anti-aging effect was found by Bushen Shengxue drug to treat Wistar rats. Using a method about incorporation of 3H-labeled methyl group of S-adenosyl-methionine (SAM) into DNA bases, the DNA methylase activity was assayed. The specific activity of DNA methylase was increased by treatment of this drug. The chromatographic behaviour of DNA methylase from rat liver was also changed. These results showed that the mechanism of anti-aging effect of this drug is probably related to DNA methylation.
He
Z X
ZX
Dept. of Biology, Beijing Normal University.
Wei
W
W
Wu
Z K
ZK
D000375:Aging / Q000187:drug effects*; D000818:Animals; D015254:DNA Modification Methylases / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D015254:DNA Modification Methylases