title: Acetazolamide challenge for three-dimensional time-of-flight MR angiography of the brain.
abstract: OBJECTIVE
  We compared three-dimensional time-of-flight MR angiograms obtained before and after acetazolamide administration to evaluate whether use of this drug could improve visualization of small peripheral intracranial arteries and atherosclerotic stenosis.
  
  
  METHODS
  For evaluation of small peripheral arteries, 10 patients with clinical diagnosis of ischemic cerebrovascular disease and 10 healthy volunteers were investigated, and for evaluation of stenosis, another 6 patients were investigated. Vascular images were obtained by three-dimensional time-of-flight MR angiography. After a baseline scan, 17 mg/kg acetazolamide was injected intravenously and the second scan was performed 20 minutes later.
  
  
  RESULTS
  Several small peripheral arteries that had not been seen on the baseline images were visible on the acetazolamide images without any augmentation of the background signals. Stenotic lesions in the main trunks of the major cerebral arteries were detected more clearly on acetazolamide images.
  
  
  CONCLUSIONS
  Acetazolamide improves visualization of small peripheral intracranial arteries and sensitivity in detecting atherosclerotic stenosis in the main trunk of major cerebral artery by three-dimensional time-of-flight MR angiography without changing MR apparatus and software.
authors.affiliation: Department of Internal Medicine, Osaka Rosai Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mandai
authors.forename: K
authors.initials: K
authors.lastname: Sueyoshi
authors.forename: R
authors.initials: R
authors.lastname: Fukunaga
authors.forename: M
authors.initials: M
authors.lastname: Nukada
authors.forename: F
authors.initials: F
authors.lastname: Ohtani
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
authors.forename: I
authors.initials: I
authors.lastname: Tsukaguchi
authors.forename: H
authors.initials: H
authors.lastname: Abe
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D001158:Arteries; D002545:Brain Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging; D002531:Cerebellum / Q000098:blood supply; D002533:Cerebral Angiography; D002539:Cerebral Arterial Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D002536:Cerebral Arteries / Q000473:pathology*; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007089:Image Enhancement; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D000086:Acetazolamide