title: Effect of insulin and isoproterenol on lipid metabolism in porcine adipose tissue from different depots.
abstract: Significant differences were found in the rates of lipogenesis, glucose oxidation and lipolysis in porcine adipose tissue from four depots; outer subcutaneous (OSC), middle subcutaneous (MSC), perirenal (PR) and omental (OM). Lipogenesis was stimulated by insulin in all depots in the order PR > OM > MSC > OSC. Lipolysis was stimulated by isoproterenol in all depots in the order PR > OM > MSC > OSC. Differences in lipid metabolism by the different depots may have an important impact on lipid accretion in vivo.
authors.affiliation: Department of Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agricultural and Food Sciences, Loughborough, U.K.
authors.forename: T J
authors.initials: TJ
authors.lastname: Budd
authors.forename: J L
authors.initials: JL
authors.lastname: Atkinson
authors.forename: P J
authors.initials: PJ
authors.lastname: Buttery
authors.forename: A M
authors.initials: AM
authors.lastname: Salter
authors.forename: J
authors.initials: J
authors.lastname: Wiseman
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D048429:Cell Size; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D007668:Kidney; D050356:Lipid Metabolism; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009852:Omentum; D010084:Oxidation-Reduction; D012867:Skin; D013552:Swine; D014018:Tissue Distribution
chemical_list: D007328:Insulin; D005947:Glucose; D007545:Isoproterenol