[Experimental study on huogu granule in treating aseptic necrosis of femur head].
The pharmacological activities and acute toxicological activities of Huogu Granule (HGG) on the basis of clinical treatment of aseptic necrosis of head of femur were studied. It was observed that medium and high dose of HGG could reduce the inflammatory reaction, inhibit the enhancement of the capillary permeability and decrease the frequency of body twisting obviously in mice. All of these were significantly better than that of normal saline control group (P < 0.05, P < 0.01). It showed that HGG had a noticeable anti-inflammatory and analgesic effect. Also HGG was found to improve the absorption of serum Ca, P and the development of femoral growth in chicken embryo. LD50 could not be determined in acute toxicity test, although the dose of 50g/kg.24hr was about 166.7 times of the dosage used for human adult clinically. It demonstrated that the acute toxicity of HGG is negligible.
Li
Y X
YX
203 Hospital of PLA, Heilongjiang.
Xiao
S C
SC
Li
T F
TF
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002642:Chick Embryo; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D005271:Femur Head Necrosis / Q000188:drug therapy*; D051379:Mice
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal