Identification of the triggers of celiac sprue.
Three theoretically antigenic synthetic peptide subunits of alpha-gliadin were evaluated in vivo in four patients with celiac disease. A sequence of alpha-gliadin (amino acids 31-49) was toxic in all patients, suggesting that this sequence is one of the triggers of the immune system in celiac sprue.
Saltzman
J R
JR
Division of Digestive Diseases and Nutrition, University of Massachusetts Medical Center, Worcester 01655.
Clifford
B D
BD
D000595:Amino Acid Sequence; D000941:Antigens / Q000737:chemistry / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology*; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*
D000941:Antigens; D010446:Peptide Fragments; D005903:Gliadin