title: Bone marrow transplantation in patients with acute leukemia.
abstract: At least three factors may be responsible for leukemic relapse in patients receiving ABMT: (a) minimal residual disease; (b) leukemic cells reinfused with the graft; and (c) the lack of a graft-versus leukemia effect. Techniques for pharmacological marrow decontamination, clinical result obtained with ABMT and the efficacy of ABMT with mafosfamide purged marrow in patients with acute myelogenous leukemia are reviewed.
authors.affiliation: Department of Hematology, University of Parma.
authors.forename: C
authors.initials: C
authors.lastname: Caramatti
authors.forename: L
authors.initials: L
authors.lastname: Mangoni
authors.forename: C
authors.initials: C
authors.lastname: Carlo-Stella
authors.forename: V
authors.initials: V
authors.lastname: Rizzoli
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects; D016026:Bone Marrow Transplantation / Q000379:methods; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D012008:Recurrence; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; C048341:mafosfamide; D003520:Cyclophosphamide