title: Tricyclic heteroaromatic systems. 2-Phenyl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-one: a novel benzodiazepine receptor ligand.
abstract: The synthesis, unambiguous proof of structure and benzodiazepine receptor affinity and efficacy of 2-phenyl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-one 1 are reported. The in vitro biological data indicate that 1 may be the lead compound of a new class of benzodiazepine antagonist-inverse agonist ligands.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Catarzi
authors.forename: L
authors.initials: L
authors.lastname: Cecchi
authors.forename: V
authors.initials: V
authors.lastname: Colotta
authors.lastname: Filacchioni
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: L
authors.initials: L
authors.lastname: Giusti
authors.forename: A
authors.initials: A
authors.lastname: Lucacchini
authors.forename: G
authors.initials: G
authors.lastname: Valle
mesh_terms: D000818:Animals; D048588:Benzoxazines; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002417:Cattle; D018360:Crystallography, X-Ray; D005445:Flunitrazepam / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D048588:Benzoxazines; D008024:Ligands; D010078:Oxazines; D011963:Receptors, GABA-A; D014230:Triazoles; C087745:2-phenyl-1,2,4-triazolo(1,5-c)(1,3)benzoxazin-5-one; D005445:Flunitrazepam