title: Multicenter trial of Towne strain attenuated virus vaccine in seronegative renal transplant recipients.
abstract: The Towne strain of attenuated CMV vaccine was compared with placebo in seronegative renal transplants who later received kidneys from seropositive donors. This was a double-blind, randomized, placebo-controlled trial conducted at 3 different institutions. The results were consistent with 2 prior studies, in that whereas mild CMV disease was only slightly and insignificantly reduced in vaccine recipients, severe disease was markedly reduced. In the current study, all 4 severe cases of CMV disease occurred in placebo recipients, for an incidence of 17%, versus 0% in vaccine recipients (P < 0.03). Thus, prior immunization rendered seronegative patients more resistant to the effects of CMV infection.
authors.affiliation: Pasteur-Mérieux Connaught, Marnes-La-Coquette, France.
authors.forename: S A
authors.initials: SA
authors.lastname: Plotkin
authors.forename: R
authors.initials: R
authors.lastname: Higgins
authors.forename: J B
authors.initials: JB
authors.lastname: Kurtz
authors.forename: P J
authors.initials: PJ
authors.lastname: Morris
authors.forename: D A
authors.initials: DA
authors.lastname: Campbell
authors.forename: T C
authors.initials: TC
authors.lastname: Shope
authors.forename: S A
authors.initials: SA
authors.lastname: Spector
authors.forename: W M
authors.initials: WM
authors.lastname: Dankner
mesh_terms: D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000517:prevention & control*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000627:therapeutic use; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines