title: Cyclosporine pharmacokinetics in nephrotic and kidney-transplanted children.
abstract: The pharmacokinetic parameters of cyclosporine (CsA) were determined in 23 kidney transplant recipients and 19 children with nephrotic syndrome, after intravenous and oral administration. The mean bioavailability was 39%, blood clearance was 0.55 l.h-1.kg-1 and volume of distribution at steady-state was 2.77 l.kg-1. The absorption profile was monophasic (67%), biphasic (29%) or poor (4%). The maximum blood concentration of CsA was significantly higher in children with a monophasic profile than in children with a biphasic profile (550 vs 380 ng.ml-1). Blood clearance was significantly higher in the transplant recipients than in the patients with nephrotic syndrome (0.65 vs 0.43 l.h-1.kg-1. Although age, haematocrit, creatinine clearance, serum albumin and cholesterol differed between the two groups, only haematocrit and creatinine clearance were significantly (negatively) correlated with CsA clearance.
authors.affiliation: Department of Clinical Pharmacology, Hôpital Robert Debrè, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Jacqz-Aigrain
authors.forename: C
authors.initials: C
authors.lastname: Montes
authors.forename: P
authors.initials: P
authors.lastname: Brun
authors.forename: C
authors.initials: C
authors.lastname: Loirat
mesh_terms: D000042:Absorption; D000293:Adolescent; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D009404:Nephrotic Syndrome / Q000378:metabolism*
chemical_list: D016572:Cyclosporine