A tremor syndrome with a central axonopathy in Scottish terriers.
A central axonopathy in 2 male and 1 female Scottish Terrier puppies from 3 different but related litters is reported. Clinical signs consisting of severe whole-body tremors and ataxia were first detected at the age of 10 to 12 weeks. They worsened with activity and excitement and diminished during rest or sleep. Two dogs also had paraparesis. In 1 dog the neurological deficits progressed over several months. Neuropathological examination revealed widespread axonal changes, vacuolation, and gliosis in the white matter of the central nervous system.
Van Ham
L
L
Department of Small Animal Medicine, Ghent University, Belgium.
Vandevelde
M
M
Desmidt
M
M
Tshamala
M
M
De Schaepdrijver
L
L
Mattheeuws
D
D
D000818:Animals; D001259:Ataxia / Q000473:pathology / Q000662:veterinary; D001369:Axons / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D009457:Neuroglia / Q000473:pathology; D013577:Syndrome; D014202:Tremor / Q000473:pathology / Q000662:veterinary*; D014617:Vacuoles / Q000473:pathology