Variations in strength of the porcine aorta as a function of location.
Dissecting aneurysms split the wall of the aorta and other large arteries to create a false lumen in parallel with the true lumen. Experiments were designed to determine the pressure required to tear the media and the work required per unit area to propagate the dissection once it started. India ink was injected into the media of 17 opened porcine aortas through a needle inserted parallel to the lumen of opened aortas placed in a saline bath. The ink was infused at 0.9 ml/min with a constant infusion pump as the pressure was monitored with a pressure transducer. The size of the bleb formed by the ink in the media was recorded with a video camera mounted perpendicular to the lumenal surface. All data were recorded on a computer. The pressure-volume curve was used to obtain the distensibility of the media (the upslope), the peak pressure, the tearing pressure, and the work of dissection (the area under the P-V curve once tearing occurred). The projected area of the bleb was calculated from the video images, and the work/area was calculated. The peak pressures were always extremely high, and ranged from 634 +/- 204 (SD) mmHg for the lower abdominal aorta to 816 +/- 145 mmHg for the lower thoracic aorta. The work/area ranged from 1.88 +/- 0.89 mJ/cm2 for the upper abdominal aorta to 11.34 +/- 4.05 mJ/cm2 for the lower abdominal aorta. An ANOVA showed that the lower abdominal aorta tore at lower pressures initially, but required much more energy to propagate the dissection. We believe that this is because of structural differences in the elastin pattern in the abdominal aorta.
Roach
M R
MR
Department of Medical Biophysics, University of Western Ontario, London, Canada.
Song
S H
SH
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000737:chemistry / Q000502:physiology*; D001012:Aorta, Abdominal / Q000033:anatomy & histology / Q000502:physiology; D001013:Aorta, Thoracic / Q000033:anatomy & histology / Q000502:physiology; D004549:Elastin / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011312:Pressure; D013552:Swine; D013718:Tensile Strength
D004549:Elastin