title: Partial hypopituitarism following total body irradiation in adult patients with haematological malignancy.
abstract: We present the endocrine parameters of two adult patients with partial hypopituitarism documented at 6 and 8 months after chemotherapy, single fraction total body irradiation (10.5 Gy) and autologous bone marrow transplantation. The hormone profiles demonstrate severe somatotroph insufficiency and impaired adrenocorticotroph secretory capacity, despite sparing of the gonadotroph compartment. We recommend stimulatory testing of hypothalamic-pituitary function from 3 months post-transplant, as basal hormonal concentrations may be equivocal, and supplementation may significantly improve quality of life.
authors.affiliation: Department of Haematology, University College Hospital, London, UK.
authors.forename: W
authors.initials: W
authors.lastname: Mills
authors.forename: R
authors.initials: R
authors.lastname: Chatterjee
authors.forename: H H
authors.initials: HH
authors.lastname: McGarrigle
authors.forename: D C
authors.initials: DC
authors.lastname: Linch
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D003366:Cosyntropin / Q000627:therapeutic use; D006728:Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007018:Hypopituitarism / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000628:therapy*; D011863:Radioimmunoassay; D014182:Transplantation, Autologous; D014916:Whole-Body Irradiation / Q000009:adverse effects*
chemical_list: D006728:Hormones; D003366:Cosyntropin; C006418:adrenocorticotropin zinc; D006854:Hydrocortisone