Early- and late-onset pelvic inflammatory disease among women with cervical Chlamydia trachomatis infection at the time of induced abortion--a follow-up study.
After termination of a double-blind, randomized study on erythromycin in the prevention of post-abortion infection, 34 women (14 treated with erythromycin, 20 not treated with erythromycin) harbouring Chlamydia trachomatis were followed up within 6 weeks and again 2 to 24 months after the abortion in order to detect an early- and late-onset pelvic inflammatory disease (PID). For statistical analysis survival analysis by Kaplan-Meir estimates and Mantel-Cox test were carried out. Untreated women with C. trachomatis infection at the time of abortion had a cumulative risk of 72% of developing early and/or late PID, if observed for 24 months. This cumulative risk was significantly reduced to 8% if the C. trachomatis infection was treated at the time of the abortion. Screening for and treatment of C. trachomatis is warranted, especially in women < or = 25 years old, to avoid early and late-onset PID after induced first trimester abortion.
Sørensen
J L
JL
Dept. of Gynecology and Obstetrics, Rigshospitalet, Copenhagen O.
Thranov
I
I
Hoff
G
G
Dirach
J
J
D000028:Abortion, Induced / Q000009:adverse effects*; D002690:Chlamydia Infections / Q000150:complications / Q000517:prevention & control*; D002692:Chlamydia trachomatis; D004311:Double-Blind Method; D004917:Erythromycin / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*; D011261:Pregnancy Trimester, First; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D002577:Uterine Cervical Diseases / Q000150:complications / Q000517:prevention & control*
D004917:Erythromycin