title: Racial differences in the age-related increase in left ventricular mass in youths.
abstract: We determined the factors related to left ventricular mass adjusted for body size in 60 black (mean age, 13 +/- 2 years) and 40 white (mean age, 14 +/- 2 years) normotensive youths. The factors examined included age, sex, systolic blood pressure, diastolic blood pressure, plasma renin activity, plasma aldosterone concentration, and sodium and potassium intake as determined by 24-hour excretion. Sex (beta = 13.3, P < .003), age (beta = 2.88, P < .001), and systolic blood pressure (beta = 0.41, P < .02) were independent predictors in the sample as a whole, accounting for 37% of the variance of left ventricular mass adjusted for height. Separate analyses were performed for black and white subjects. In the black subjects, age (beta = 4.4, P < .004) followed by sex (beta = 11.85, P < .02) were independent factors, accounting for 43% of the variance of left ventricular mass adjusted for height. In contrast, in white subjects systolic blood pressure (beta = 0.4, P < .003) followed by sodium excretion (beta = 0.13, P < .05) were independent factors, with gender (beta = 8.89, P < .07) tending to account for 36% of the variance. Similar results were observed for left ventricular mass adjusted for body surface area. In conclusion, the age-related increase in adjusted left ventricular mass in black but not white youths may in part account for the early development of cardiovascular disease among the black population.
authors.affiliation: Department of Pediatrics, University of Tennessee, Memphis 38163.
authors.forename: G A
authors.initials: GA
authors.lastname: Harshfield
authors.forename: D W
authors.initials: DW
authors.lastname: Koelsch
authors.forename: D A
authors.initials: DA
authors.lastname: Pulliam
authors.forename: B S
authors.initials: BS
authors.lastname: Alpert
authors.forename: P A
authors.initials: PA
authors.lastname: Richey
authors.forename: J A
authors.initials: JA
authors.lastname: Becker
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology*; D000450:Aldosterone / Q000097:blood; D044383:Black People; D001794:Blood Pressure; D002648:Child; D005260:Female; D006321:Heart / Q000033:anatomy & histology*; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D009318:Natriuresis; D011188:Potassium / Q000652:urine; D012016:Reference Values; D012083:Renin / Q000097:blood; D044465:White People
chemical_list: D000450:Aldosterone; D012083:Renin; D011188:Potassium