Evolving concepts in molecular pathology.
During the last decade, an understanding of the causes of many human diseases has progressed rapidly, in large measure because of the development of technologies that allow us to identify the genes that are involved. Identification of a gene that is suspected to play an important role in a particular disease opens up a whole new dimension of research to understand the molecular events that underlie the cause of that disorder. A crucial step in this process is often the development of an animal model of the disease. Again, the last decade has seen rapid advances in our ability to create such models, particularly in mice. Technologies that allow for the addition, alteration, or elimination of individual genes from the genome to create a transgenic mouse are now routine. The advantages of having a transgenic mouse model of a human disease are many. These animals often provide the first unequivocal proof that a particular gene is responsible for causing the pathological changes that occur with disease. They also can provide a system to carefully dissect the successive events that lead to the disease state, and can provide a custom-designed whole animal system to test potential therapies to treat and eventually cure the disease. Most important, new concepts relating to gene expression and gene function in disease often emerge from such transgenic studies. This review will illustrate several examples in which transgenic animals have contributed significantly to the evolution of concepts of the underlying mechanisms of human disease.
Kappel
C A
CA
Department of Virology, Jerome H. Holland Laboratory, Rockville, Maryland 20855.
Bieberich
C J
CJ
Jay
G
G
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000473:pathology; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics / Q000473:pathology; D016923:Cell Death; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000473:pathology; D016110:Epidermolysis Bullosa Simplex / Q000235:genetics / Q000473:pathology; D005823:Genetics; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D010336:Pathology