Fluoride, remineralization and root caries.
This paper reviews the probable mechanism of dental caries and the role of fluoride in the inhibition or reversal of that process. The initial stages of root caries are comparable to enamel caries, being the acid dissolution of mineral resulting from acids generated by bacterial metabolism. The fermentation of carbohydrates by oral bacteria including mutans streptococci and lactobacilli initiate the root caries process, removing mineral from among the organic matrix which is primarily composed of collagen. Subsequent to this demineralization, the organic material can be further broken down by bacterial enzymes. Fluoride inhibits mineral loss during the acid dissolution process and enhances remineralization in a similar manner to that which occurs in dental enamel.
Featherstone
J D
JD
Department of Oral Sciences, Eastman Dental Center, Rochester, New York.
D001419:Bacteria / Q000187:drug effects; D003804:Dentin / Q000737:chemistry; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017213:Root Caries / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*
D005460:Fluorides, Topical