[Synthesis and antibacterial activities of 1-amino-6-fluoro-1,4-dihydro-4-oxo-7-(substituted) piperazinyl-3-quinolinecarboxylic acids and their derivatives].
The title compounds 6-24 were obtained by the reaction of 5 with corresponding benzaldehydes. 5 was prepared with ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylate by hydrolysis, amination and condensation with piperazine. Anti-bacterial activities of 5-24 were tested in vitro.
Xin
T
T
Shanghai Institute of Pharmaceutical Industry.
Ding
J
J
Zhang
X P
XP
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D012760:Shigella / Q000187:drug effects
D000634:Aminoquinolines; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010879:Piperazines; D015363:Quinolones