title: Scanning electron microscopic evaluation of age-related changes in the rat vestibular epithelium.
abstract: An ultrastructural study was performed to assess age-related changes in the vestibular end organs of Fischer 344 rats. The surfaces of the maculae and cristae from 3-, 12-, and 24-month-old Fischer 344 rats were observed by use of scanning electron microscopy. Age-related changes in the morphology of the vestibular neuroepithelium included a substantial loss of hair cells, as well as a reduction in the number of kinocilia and stereocilia on those that remained. These changes were greatest in the central upper regions of the three ampullae. In aged animals a greater area of the neuroepithelial surface was covered with microvilli, and in some instances, giant cilia were found among the microvillous surfaces. In contrast, there were few differences among the three age groups in the number and condition of hair cells in the saccules and utricles. The changes observed in the cristae may contribute to the age-associated impairment of vestibular function. If similar changes occur in human beings, these could in part account for the presbycusis observed in the elderly.
authors.affiliation: Department of Surgery, Southern Illinois University School of Medicine, Springfield 62794-9230.
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: R H
authors.initials: RH
authors.lastname: Helfert
authors.forename: H R
authors.initials: HR
authors.lastname: Konrad
authors.forename: D M
authors.initials: DM
authors.lastname: Caspary
mesh_terms: D008267:Acoustic Maculae / Q000648:ultrastructure; D000375:Aging / Q000473:pathology*; D000818:Animals; D002923:Cilia / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D018069:Hair Cells, Vestibular / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000648:ultrastructure; D009411:Nerve Endings / Q000648:ultrastructure; D051381:Rats; D011916:Rats, Inbred F344; D012444:Saccule and Utricle / Q000648:ultrastructure; D012665:Semicircular Canals / Q000648:ultrastructure; D014725:Vestibular Nerve / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000648:ultrastructure*