Cryptococcus neoformans infection can elicit protective antibodies in mice.
An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.
Mukherjee
J
J
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Scharff
M D
MD
Casadevall
A
A
D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D002460:Cell Line; D003453:Cryptococcosis / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D003455:Cryptococcus neoformans / Q000276:immunology*; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D009895:Opsonin Proteins; D009929:Organ Size; D011134:Polysaccharides / Q000097:blood / Q000276:immunology; D016019:Survival Analysis
D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D011134:Polysaccharides; C014426:cryptococcal polysaccharide