Lack of pharmacokinetic interaction between vinpocetine and oxazepam.
The influence of multiple doses of vinpocetine (10 mg three times daily) on the steady state plasma concentrations of oxazepam (10 mg three times daily) was studied in 16 healthy subjects. The mean (+/- s.d.) AUC (ng ml-1h-1) of oxazepam over 24 h during combined treatment was 4716 +/- 2296 and for oxazepam treatment alone it was 4737 +/- 2448 (95% confidence intervals for ratio of means = 95.4-103.7%). The degree of plasma protein binding of oxazepam was 98.11 +/- 0.32% and was not affected by vinpocetine. Independent of vinpocentine treatment a significant diurnal change in the plasma binding of oxazepam was observed; the free drug fraction was 20% higher during the night than during the day. Cmax and AUC values based on total oxazepam in plasma were 10% lower during the night. The results indicate a lack of influence of vinpocetine on oxazepam kinetics. Diurnal changes in the plasma binding of oxazepam probably have no clinical consequences.
Storm
G
G
Pharma Bio-Research International B.V., Zuidlaren, The Netherlands.
Oosterhuis
B
B
Sollie
F A
FA
Visscher
H W
HW
Sommer
W
W
Beitinger
H
H
Jonkman
J H
JH
D000328:Adult; D000704:Analysis of Variance; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D016001:Confidence Intervals; D018592:Cross-Over Studies; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010076:Oxazepam / Q000097:blood / Q000493:pharmacokinetics*; D011485:Protein Binding; D016037:Single-Blind Method; D013056:Spectrophotometry, Ultraviolet; D014665:Vasodilator Agents / Q000493:pharmacokinetics*; D014748:Vinca Alkaloids / Q000097:blood / Q000493:pharmacokinetics*
D001798:Blood Proteins; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D010076:Oxazepam