Suppression of HIV replication by CD8+ cell clones derived from HIV-infected and uninfected individuals.
CD8+ cell clones have been derived from peripheral blood mononuclear cells of human immunodeficiency virus (HIV)-infected and uninfected individuals. Several of these cloned cells have the ability to suppress HIV replication when cocultured with CD4+ cells acutely infected in the laboratory with HIV or with infected CD4+ cells from infected subjects. Suppression of virus production occurs without killing the target cells. With the CD8+ cell clones studied, this antiviral response correlated with production of a filterable factor that has antiviral activity. These cell clones offer the opportunity for identification of the factor mediating suppression of HIV replication. Moreover, adoptive transfer of cell clones might provide a valuable therapeutic approach for HIV-infected individuals.
Hsueh
F W
FW
Department of Medicine, University of California, School of Medicine, San Francisco 94143.
Walker
C M
CM
Blackbourn
D J
DJ
Levy
J A
JA
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D006801:Humans; D014779:Virus Replication / Q000276:immunology*