[Alcohol intake, Lewis phenotypes and risk of ischemic heart disease. The Copenhagen Male Study].
In the Copenhagen Male Study we found an increased risk of ischaemic heart disease (IHD) in men with the Lewis phenotype Le(a-b-). This study investigated whether, within the group of Le(a-b-) men, any conventional risk factors modified their increased risk. Three thousand, three hundred and eighty-three men aged 53 to 75 years were examined in 1985/86 and their morbidity and mortality over the next four years recorded. Three hundred and forty-three men with cardiovascular diseases were excluded at baseline. Potential risk factors examined were: alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body mass index, blood pressure, hypertension, non-insulin dependent diabetes mellitus and social class. In eligible men with Le(a-b-), N = 280 (9.6%), alcohol was the only risk factor associated with risk of IHD. There was a significant inverse dose-effect relationship between alcohol consumption and risk. The age-adjusted p-values of trend tests were for risk of non-fatal + fatal IHD: p = 0.03; for risk of fatal IHD: p = 0.02. In eligible men with other phenotypes, N = 2,649 (90.4%) only a limited and non-significant negative association with alcohol. In Le(a-b-) men, a group genetically at increased risk of IHD, the risk was strongly and significantly negatively correlated with alcohol consumption.
Hein
H O
HO
Rigshospitalet, København.
Sørensen
H
H
Suadicani
P
P
Gyntelberg
F
F
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications*; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D006801:Humans; D007983:Lewis Blood Group Antigens; D008019:Life Style; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology* / Q000235:genetics / Q000401:mortality; D010641:Phenotype; D011446:Prospective Studies; D012307:Risk Factors
D007983:Lewis Blood Group Antigens
Alkoholindtagelse, Lewis-faenotyper og risiko for iskaemisk hjertesygdom. The Copenhagen Male Study.