title: Noninvasive measurement of forearm blood flow and oxygen consumption by near-infrared spectroscopy.
abstract: We applied near-infrared spectroscopy (NIRS) for the simultaneous measurement of forearm blood flow (FBF) and oxygen consumption (VO2) in the human by inducing a 50-mmHg venous occlusion. Eleven healthy subjects were studied both at rest and after hand exercise during vascular occlusion. FBF was also measured by strain-gauge plethysmography. FBF measured by NIRS was 1.9 +/- 0.8 ml.100 ml-1.min-1 at rest and 8.2 +/- 2.9 ml.100 ml-1.min-1 after hand exercise. These values showed a correlation (r = 0.94) with those obtained by the plethysmography. VO2 values were 4.6 +/- 1.3 microM O2 x 100 ml-1.min-1 at rest and 24.9 +/- 11.2 microM O2 x 100 ml-1.min-1 after hand exercise. The scatter of the FBF and VO2 values showed a good correlation between the two variables (r = 0.93). The results demonstrate that NIRS provides the particular advantage of obtaining the contemporary evaluation of blood flow and VO2, allowing correlation of these two variables by a single maneuver without discomfort for the subject.
authors.affiliation: Istituto di Anestesiologia e Rianimazione, I Università di Roma, Italy.
authors.forename: R A
authors.initials: RA
authors.lastname: De Blasi
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Natali
authors.forename: G
authors.initials: G
authors.lastname: Conti
authors.forename: A
authors.initials: A
authors.lastname: Mega
authors.forename: A
authors.initials: A
authors.lastname: Gasparetto
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006225:Hand / Q000502:physiology; D006452:Hemoglobinometry; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D010108:Oxyhemoglobins / Q000032:analysis; D010992:Plethysmography, Impedance; D012039:Regional Blood Flow / Q000502:physiology; D012146:Rest / Q000502:physiology; D013055:Spectrophotometry, Infrared
chemical_list: D010108:Oxyhemoglobins