Statistical significance of amino acid sequence similarity in type II DNA methyltransferases.
The statistical significance of amino acid sequence similarities previously observed in type II DNA methyltransferases has been investigated. It is shown: (1) that the intramolecular similarities observed among various type II Mtases are not statistically significant and thus can not be used to support a gene duplication model; (2) that the intermolecular similarities observed in a peptide in various type II adenine methylases are statistically confirmed; (3) that the similarities observed between MutH and these proteins for this peptide are not statistically significant and therefore cannot be used to propose a functional role in DNA recognition for this peptide.
Guyot
J B
JB
Département de Biologie Cellulaire et Moléculaire, Centre d'Etudes de Saclay, Gif-sur-Yvette, France.
Caudron
B
B
D000595:Amino Acid Sequence; D003627:Data Interpretation, Statistical; D008969:Molecular Sequence Data; D005810:Multigene Family; D011497:Protein O-Methyltransferase / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D011497:Protein O-Methyltransferase