title: [Infectious endocarditis and congenital heart defects in adults].
abstract: BACKGROUND
  Infective endocarditis still remains a cardiological menace. However, the type of predisposing diseases has changed: the incidence of rheumatic heart disease in advanced countries has declined, advances made in the surgical and medicamentous treatment of inborn heart disease are the reasons why we are encountering, with increasing frequency, infective endocarditis which develops on their background.
  
  
  RESULTS
  The objective of the investigation was to assess the frequency of infective endocarditis and predisposing diseases. During the time interval between 1987 and 1991 16 patients (50% younger than 50 years) were hospitalized with the diagnosis of infective endocarditis. Rheumatic valvular damage and inborn heart disease were the predisposing factor in 25%. All patients were younger than 30 years (mean 24, range 18-30), and half the patients suffered from defects of the ventricular septum. Other defects were tetralogy of Fallot and inborn aortic stenosis. In 10% of the patients infective endocarditis developed on the background of a mitral valve prolapse with regurgitation. Echocardiographic examination confirmed the diagnosis in almost 70% by revealing vegetation. Bacteriological examination revealed the agent in 60%, most frequently it was Streptococcus viridans. The mortality rate in the group was 13%.
  
  
  CONCLUSIONS
  The recorded incidence of infective endocarditis, 1.5 pro mille, is consistent with data in the literature. Corrected and not corrected heart disease plays an important role as predisposing disease. Despite the opportunity of intensive antibiotic treatment, the mortality remains high--13%.
authors.affiliation: I. interní klinika 2. LF UK, Praha-Motol.
authors.forename: J
authors.initials: J
authors.lastname: Charvát
authors.forename: K
authors.initials: K
authors.lastname: Hlavácek
authors.forename: F
authors.initials: F
authors.lastname: Kölbel
mesh_terms: D000293:Adolescent; D000328:Adult; D004697:Endocarditis, Bacterial / Q000150:complications*; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans
vernacular_title: Infekcní endokarditida a vrozené srdecní vady v dospĕlosti.