title: Gastric emptying of liquid meals measured noninvasively in humans with [13C]acetate breath test.
abstract: The aim of the present study was to develop a breath test to measure liquid gastric emptying rates that would be without radiation exposure and applicable to field testing. Four different test meals were investigated: a glucose meal, an amino acid meal, a fat meal, and a mixed meal (Ensure). The test meals were labeled with two markers, [13C]acetate and PEG-4000 (polyethylene glycol 4000). Gastric emptying rates were measured simultaneously by both breath test and the double-indicator technique in eight healthy male subjects. The appearance of 13CO2 in the breath closely reflected gastric emptying of the four test meals as measured by the double-indicator technique. It is concluded that the [13C]acetate breath test is a reliable, noninvasive test to measure gastric emptying rates of liquid test meals.
authors.affiliation: Division of Gastroenterology, University Hospital, Basel, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Mossi
authors.forename: B
authors.initials: B
authors.lastname: Meyer-Wyss
authors.forename: C
authors.initials: C
authors.lastname: Beglinger
authors.forename: W
authors.initials: W
authors.lastname: Schwizer
authors.forename: M
authors.initials: M
authors.lastname: Fried
authors.forename: A
authors.initials: A
authors.lastname: Ajami
authors.forename: R
authors.initials: R
authors.lastname: Brignoli
mesh_terms: D000085:Acetates; D000328:Adult; D001944:Breath Tests; D002247:Carbon Isotopes; D005217:Fat Emulsions, Intravenous; D005526:Food, Formulated; D005746:Gastric Emptying; D006801:Humans; D008297:Male; D011092:Polyethylene Glycols; D015203:Reproducibility of Results
chemical_list: D000085:Acetates; D002247:Carbon Isotopes; D005217:Fat Emulsions, Intravenous; D011092:Polyethylene Glycols