Evaluation of deprenyl for cocaine-like discriminative stimulus effects in rats.
The antiparkinsonian agent l-deprenyl is metabolized to l-methamphetamine and l-amphetamine and, at higher doses, can facilitate the release and inhibit the reuptake of dopamine. Since l-deprenyl can affect dopamine release and reuptake it was important to evaluate it for cocaine-like discriminative stimulus effects. Male Fisher rats were trained to discriminate cocaine (10 mg/kg, i.p.) from saline in a two-lever, operant-conditioning procedure using schedules of food-delivery or stimulus-shock termination. l-Deprenyl (17 mg/kg, i.p.) produced full generalization to cocaine under the food-delivery schedule but this or higher doses produced only partial generalization to cocaine under the stimulus-shock termination schedule. d-Deprenyl produced full generalization to cocaine under both schedules at i.p. doses of 5.6 to 10 mg/kg. These cocaine-like discriminative stimulus effects occur only at doses that are well above the clinically relevant dose range for l-deprenyl.
Yasar
S
S
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Medical School, Baltimore, MD.
Schindler
C W
CW
Thorndike
E B
EB
Goldberg
S R
SR
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004193:Discrimination Learning; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D005502:Food; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012642:Selegiline / Q000494:pharmacology*; D013237:Stereoisomerism
D012642:Selegiline; D003042:Cocaine