[The Longmire gastrectomy in the animal model: postoperative changes in fat resorption and the hormones cholecystokinin and secretin].
In this animal study we investigated the absorption of free fatty acids and triglycerides after gastrectomy. The levels of the hormones cholecystokinin and secretin were measured in response to a controlled enteral fat load (Lipofundin 20% MCT emulsion). We studied fat absorption in three groups of animals: the gastrectomy group in which lipid emulsion was administered in the duodenum, and two groups of controls that received the same infusion in the duodenum or stomach, respectively. Infusing the fat load directly into the duodenum, rather than the stomach, resulted in delayed absorption of fatty acids. In the gastrectomized animals there was, in addition, increased absorption of triglycerides. Medium- and long-chain fatty acids were found to be an adequate stimulus for secretion of the gastrointestinal hormones cholecystokinin (CCK) and secretin. In the gastrectomized group, higher baseline levels of both CCK and secretin were observed. CCK showed no response to the lipid stimulus, whereas a secretin response was observed over and above the raised baseline level. The gastrectomized animals showed a markedly restricted growth rate, as measured by body weight; however, they continued to gain weight in a linear fashion up to the end of the study period. No alterations in morphology of CCK-secreting cells were found.
Klein
P
P
Chirurgische Universitätsklinik, Universität Erlangen-Nürnberg.
Reingruber
B
B
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002766:Cholecystokinin / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005743:Gastrectomy / Q000379:methods*; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011178:Postgastrectomy Syndromes / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012633:Secretin / Q000378:metabolism*; D013012:Sorbitol / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D004041:Dietary Fats; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides; C008288:Lipofundin; D012633:Secretin; D013012:Sorbitol; D002766:Cholecystokinin
Die Gastrektomie nach Longmire im Tiermodell: Postoperative Veränderungen bei der Fettresorption sowie der Hormone Cholezystokinin und Sekretin.