[Leukocyte expression of the LFA-1 adhesion molecule in spondylarthropathies].
The expression of adhesion molecule Leukocyte Function Antigen-1 (LFA-1) on peripheral blood leukocytes was evaluated (using a monoclonal antibody anti CD11a/LFA-1) in 52 spondylarthropathies (SA) (35 HLA B27 positive), 12 healthy patients, 24 active rheumatoid arthritis (RA) and 12 systemic lupus (SLE) patients. LFA-1 expression on lymphocytes was similar in the different groups of patients, but LFA-1 expression on granulocytes was higher in SA than in controls (p < 0.05) or in RA or SLE. Fluorescence intensity of anti LFA-1 staining on SA granulocytes correlated with serum IgA levels. There was no difference between HLA B27 positive/negative, biologically inflammatory (CRP > 21 mg/l)/non inflammatory SA patients. This study seems to confirm the granulocyte and IgA involvement in immunopathogenesis of spondylarthropathies.
Wendling
D
D
Service de Rhumatologie, Hôpital J. Minjoz, Paris.
Racadot
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E
Viel
J F
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation; D001168:Arthritis / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007962:Leukocytes / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013166:Spondylitis / Q000097:blood* / Q000276:immunology / Q000503:physiopathology
D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D016169:Lymphocyte Function-Associated Antigen-1
Expression leucocytaire de la molécule d'adhésion LFA-1 au cours des spondylarthropathies.