Complete remission of metastasized adrenocortical carcinoma under o,p'-DDD.
The case of a 53 year old female patient with metastasized androgen producing adrenocortical carcinoma is presented. After initial adrenalectomy a local relapse had been treated by surgery and external irradiation. Solitary liver metastases had been resected repeatedly. Subsequently multiple liver metastases required systemic chemotherapy. Treatment with o,p'-DDD (initially 12 g/d, long term treatment 1.5-3 g/d) has resulted in a complete remission for nearly 4 years. Gastrointestinal side effects occurred initially but subsided with dose reduction of o,p'-DDD.
Kornely
E
E
Abteilung für Endokrinologie und Rheumatologie, Heinrich Heine Universität, Düsseldorf, Germany.
Schlaghecke
R
R
D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D000315:Adrenalectomy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D008939:Mitotane / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction
D008939:Mitotane