title: Clinical observation of neonatal gastrointestinal perforation.
abstract: BACKGROUND
  Gastrointestinal perforation is an infrequent occurrence in neonates. Experience in its management is presented, while also attempting to analyze the factors affecting outcome.
  
  
  METHODS
  From 1983 to 1992, 31 neonates with gastrointestinal perforation were treated at Taichung Veterans General Hospital. The medical records of these patients were reviewed thoroughly. In the meantime, Mann-Whitney U and Yates' correction chi square tests were used to analyze the factors predicting the outcomes.
  
  
  RESULTS
  There were 21 males and 10 females, among whom 16 were premature births. The median age at diagnosis was 5 day; half (16/31) had occurred during the first 5 days of life. Abdominal distension was the most common manifestation (87%). Hemograms at admission showed leukopenia in 32% (10/31) and thrombocytopenia in 40% (8/20) of the patients. Metabolic acidosis was present in 46% (13/28) of the patients. Peritoneal fluid and preoperative blood cultures were positive in 71% (17/24) and 50% (13/26) of the patients, and both of them had Gram-negative enterobacteriacea as the most common pathogen. The overall mortality rate was 58%. The highest mortality rate was associated with gastric perforation (100%), followed by small bowel (50%) and colon (50%) perforations. The predominant cause of perforation was necrotizing enterocolitis (14/31), with the most common site the terminal ileum (16/29). Four patients with necrotizing enterocolitis had multiple perforations. Others who underwent surgery showed single perforation. The major cause of death in those patients who received operation was sepsis (8/13). An initial arterial pH value higher than 7.25, and surgical procedure performed within two days after disease onset may predict a favorable outcome (p < 0.01).
  
  
  CONCLUSIONS
  Gastrointestinal perforation is a life-threatening complication in neonates. A better survival rate can be obtained by cooperation among neonatologists, pediatric surgeons and the nursing staff taking care of these high risk babies.
authors.affiliation: Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, R.O.C.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
authors.forename: W J
authors.initials: WJ
authors.lastname: Shian
authors.forename: W T
authors.initials: WT
authors.lastname: Chang
authors.forename: H C
authors.initials: HC
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Chi
mesh_terms: D016009:Chi-Square Distribution; D004761:Enterocolitis, Pseudomembranous / Q000150:complications; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007416:Intestinal Perforation / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D011379:Prognosis; D013272:Stomach Diseases / Q000175:diagnosis* / Q000209:etiology