A single linkage group comprising 11 polymorphic DNA markers on rat chromosome 3.
Eleven polymorphic DNA markers were mapped to rat Chromosome (Chr) 3 by linkage analysis of F2 progeny of F344/N and LEW/N rat strains. The markers, including seven genes and four anonymous loci, formed a single linkage group covering approximately 112 cM with the following order: Ptgs1 (prostaglandin G/H synthase I)-D3Arb178-Scn2a (sodium channel, type II, alpha-polypeptide)-D3Arb1-Cat (catalase)-Bdnf (brain-derived neurotropic factor)-D3Arb219-D3Arb2-Sus2 (seminal vesicle secretion II protein)-Sdc4 (ryudocan/syndecan4)-Stn1 (statin-like protein). Eight of these markers were analyzed for polymorphisms in 14 additional inbred rat strains. Three to five alleles were detected for each marker, suggesting that they are highly polymorphic and useful for genetic mapping studies with inbred rat strains. Chromosomal syntenic conservation among rats, mice and humans is also discussed.
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Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Remmers
E F
EF
Du
Y
Y
Goldmuntz
E A
EA
Mathern
P
P
Zhang
H
H
Cash
J M
JM
Crofford
L J
LJ
Wilder
R L
RL
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics*; D017931:DNA Primers; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344 / Q000235:genetics*; D011917:Rats, Inbred Lew / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics
D017931:DNA Primers; D005819:Genetic Markers; D004247:DNA