[HLA-DQ gene and susceptibility of insulin dependent diabetes mellitus in Chinese population].
Trans-racial analysis of disease association has improved mapping of MHC-linked susceptibility to insulin dependent diabetes mellitus (IDDM). In this study, the contribution of the HLA class II DQA1 and DQB1 genes was investigated. Nine DQA1 and 10 DQB1 sequence-specific oligonucleotide gene probing in 49 IDDM and 48 control subjects from Beijing showed that DQA1-A4 alleles was positively associated with the disease (RR = 11.7, Pc < 0.02) as was the Asp57 negative homozygotes of DQB1 gene (P < 0.01, RR = 5.3), and that Asp57 positive homozygote of DQB1 gene conferred protection against IDDM (P < 0.025, RR = 0.38). Compared with trans-racial study, the decrease of Asp57 negative homozygote frequence and increase of Asp57 positive homozygote frequence in Chinese population may contribute to the low incidence of IDDM.
Ji
L N
LN
Department of Endocrinology and Metabolism, People's Hospital, Second School of Clinical Medicine, Beijing Medical University.
Mao
T S
TS
Sun
J H
JH
D044466:Asian People; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004198:Disease Susceptibility; D005802:Genes, MHC Class II; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D004247:DNA