Treatment of stiff-man syndrome with intravenous immune globulin.
OBJECTIVE
To evaluate the efficacy of intravenous immune globulin (IVIG) in the treatment of stiff-man syndrome (SMS).


METHODS
An open, unblinded study of 3 patients with active disease and/or disease refractory to treatment with diazepam and/or corticosteroids.


RESULTS
All 3 bedridden patients improved substantially shortly after infusion with IVIG and regained function.


CONCLUSIONS
IVIG may be useful for the treatment of SMS.
Karlson
E W
EW
Brigham and Women's Hospital, Boston, Massachusetts.
Sudarsky
L
L
Ruderman
E
E
Pierson
S
S
Scott
M
M
Helfgott
S M
SM
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008875:Middle Aged; D016750:Stiff-Person Syndrome / Q000150:complications / Q000628:therapy*
D016756:Immunoglobulins, Intravenous