[Left ventricular involvement in mucoviscidosis after 2 years of age].
BACKGROUND
The cardiac involvement in cystic fibrosis includes the rare cardiomyopathy seen in infants and changes in left ventricular performance in older children.


METHODS
67 patients, 6 to 34 months-old (mean: 16.7), 37 male and 30 female, with cystic fibrosis, were studied. Their Shwachman score was < 70. None showed any clinical manifestations of left ventricular insufficiency, but 6 patients had right ventricular insufficiency. Echocardiography was performed on 58 patients; it showed dilation of the right ventricle in 32 of them. Left ventricular perfusion was studied with thallium 201 tomoscintigraphy and left ventricular ejection fraction with 99mTc ventriculography.


RESULTS
The left ventricular ejection fraction was < 45% in 17 patients and scintigraphy showed hypofixation in 6 of them. In contrast, only 4 of the 50 patients with left ventricular ejection fraction > 45% had thallium hypofixation.


CONCLUSIONS
Resting perfusion abnormalities are more frequent in patients with a low left ventricular ejection fraction. These perfusion abnormalities suggest that myocardial fibrosis complicates the advanced stages of cystic fibrosis.
Ambrosi
P
P
Service de Cardiologie Isotopique, Hôpital de la Timone, Marseille.
Chazalettes
J P
JP
Viard
L
L
Raynaud
M
M
Faugere
G
G
Noirclerc
M
M
Bernard
P J
PJ
D000328:Adult; D000367:Age Factors; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D008297:Male; D015635:Radionuclide Ventriculography; D013318:Stroke Volume; D013667:Technetium; D013794:Thallium Radioisotopes; D016277:Ventricular Function, Left
D013794:Thallium Radioisotopes; D013667:Technetium
L'atteinte ventriculaire gauche des mucoviscidoses après l'âge de 2 ans.