Angiogenesis: a new diagnostic aspect of obstetric and gynecologic echography.
An ultrasounds triplex system (pulsed Doppler, Color mode, B mode) has been employed to study ovarian and uterine circulatory changes in fertile, infertile and postmenopausal patients. PI and mean percentage variation of PI mean values have been used. No difference has been detected in uterine haemodynamics between fertile women and those infertile patients getting pregnant by IVF-ET procedure. Patients who did not obtain the pregnancy showed different uterine and endometrial Color Doppler patterns. Furthermore, a typical endometrial blood flow has been detected both in fertile patients and infertile patients who get pregnant. Color Doppler seems to be an useful tool in the monitoring of fibroids blood supply and the uterine blood supply, especially for the clinical monitoring of GnRH analogues therapies. The technique has been also employed for the study of ectopic pregnancy. The evaluation of both uterine and throphoblast haemodynamics has resulted in a good indicator of the pregnancy progression. Concerning the ovarian pathology the color Doppler evaluation has been useful to differentiate ovarian malignant cysts from inflammatory or disfunctional masses. Nevertheless, the most interesting results have been obtained from the study of endometrial and ovarian tumors. Indeed, in the most cases, a mass supply blood flow has been detected, although in some cases no angiogenetic color flow has been found. No difference has been found in uterine artery velocimetry between malign or benign pathologies. Furthermore, histological data supporting our findings are presented.
Locci
M
M
Laboratory of Fetal-Maternal Ultrasonography, University of Naples, II Medical School, Italy.
Nazzaro
G
G
De Placido
G
G
Nazzaro
A
A
Di Renzo
G C
GC
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006439:Hemodynamics; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000503:physiopathology; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000503:physiopathology; D008875:Middle Aged; D010053:Ovary / Q000098:blood supply*; D017698:Postmenopause; D011247:Pregnancy; D011271:Pregnancy, Ectopic; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000000981:diagnostic imaging / Q000503:physiopathology; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology; D014599:Uterus / Q000098:blood supply*