Oogram studies in mice infected with Schistosoma mansoni and treated with dexamethasone.
Mice infected with about 90 cercariae of Schistosoma mansoni (LE strain) were treated during five consecutive days with dexamethasone (50 mg/Kg, subcutaneously), starting on the 42nd day of infection. Groups of five mice were then daily sacrificed from the first day after onset of treatment until the first day after. The perfusion of the portal system was performed and a piece of the intestine was processed for qualitative and quantitative oograms. This treatment carries to larger numbers of eggs in the tissues of treated mice, when compared with untreated groups. No changes were observed in the kinetics of oviposition, as all stages of viable eggs were observed in the tissues of treated and control mice. These data reinforce the hypothesis of a partial blockade of the egg excretion in immunosuppressed mice.
Hermeto
M V
MV
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Bicalho
R S
RS
da Silva
R E
RE
de Melo
A L
AL
Pereira
L H
LH
D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D016867:Immunocompromised Host; D008297:Male; D051379:Mice; D010063:Ovum / Q000502:physiology; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
D003907:Dexamethasone