Elevation of serum group II phospholipase A2 levels in patients with advanced cancer.
To investigate the role of group II phospholipase A2 (M-PLA2) in cancer, we examined M-PLA2 serum levels in 170 pre-operative patients with various cancers and found elevated levels in 49% of them. M-PLA2 serum levels were significantly higher in patients with tumor stages T2-4, N1, M1 and stages II to IV than in T1, N0, M0 and stage I tumors, respectively. In all nine post-operative patients tested, M-PLA2 decreased 14 days after tumor resection and reduced to normal levels in 4 patients. Six of 16 carcinoma cell lines (37.5%) spontaneously secreted M-PLA2 into the culture supernatant despite the absence of IL-6 and IL-1 in 5 of the 6 lines. These results demonstrate that M-PLA2 produced by cancer cells may contribute, at least in part, to the elevation of serum M-PLA2 levels observed in cancer patients.
Yamashita
S
S
Department of Surgery II, Kumamoto University Medical School, Japan.
Ogawa
M
M
Sakamoto
K
K
Abe
T
T
Arakawa
H
H
Yamashita
J
J
D001650:Bile Duct Neoplasms / Q000201:enzymology / Q000601:surgery; D001943:Breast Neoplasms / Q000201:enzymology / Q000601:surgery; D003110:Colonic Neoplasms / Q000201:enzymology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000601:surgery; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008113:Liver Neoplasms / Q000201:enzymology / Q000601:surgery; D008175:Lung Neoplasms / Q000201:enzymology / Q000601:surgery; D009367:Neoplasm Staging; D009369:Neoplasms / Q000201:enzymology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000601:surgery; D010741:Phospholipases A / Q000097:blood* / Q000378:metabolism; D054467:Phospholipases A2; D013274:Stomach Neoplasms / Q000201:enzymology / Q000601:surgery; D014407:Tumor Cells, Cultured
D015850:Interleukin-6; D010741:Phospholipases A; D054467:Phospholipases A2