The mouse as a model for human cardiovascular disease and hyperlipidemia.
The mouse has been used as an experimental model for atherosclerosis research for only a short time; however, the sophisticated genetics of this species has resulted in a number of innovative approaches that are  not possible with other models. The availability of inbred, congenic, recombinant inbred, and mutant strains has resulted in the discovery of a number of genes affecting atherosclerosis susceptibility. More importantly, the newer genetic technologies such as quantitative trait-loci mapping, transgenic mice, and gene-targeted mice are producing important insights into atherosclerosis. This review, focusing on murine models of cardiovascular disease and hyperlipidemia, will be divided into two parts: naturally occurring models and genetically engineered models.
Paigen
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B
Jackson Laboratory, Bar Harbor, Maine.
Plump
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AS
Rubin
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EM
D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics; D051379:Mice