title: Use of budesonide Turbuhaler in young children suspected of asthma.
abstract: The question addressed in this study was the ability of young children to use a dry-powder inhaler, Turbuhaler. One hundred and sixty five children suspected of asthma, equally distributed in one year age-groups from 6 months to 8 yrs, inhaled from a Pulmicort Turbuhaler, 200 micrograms budesonide-dose-1, through a filter. The amount of drug trapped by the filter was used as a measure of drug released to the patient. None of the children had prior experience in the use of a Turbuhaler, but they were instructed carefully, together with their parents, in the clinic. The median dose released revealed an age-dependent increase, with a considerable scatter. Accordingly, the dose delivered could not be predicted in these young children. The limitation to effective use in young children appeared to be lack of sufficient co-operation, rather than physical limitations, as even some very young children appeared to obtain a sufficient activation of the device. It is likely that repeated training at home may improve these findings. In conclusion, our results indicate that dry-powder inhalers are not reliable in all circumstances for treatment of young children, and that careful and repeated tuition is required if such devices are to be used.
authors.affiliation: Dept of Paediatrics, State University Hospital, Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Bisgaard
authors.forename: S
authors.initials: S
authors.lastname: Pedersen
authors.forename: K
authors.initials: K
authors.lastname: Nikander
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009330:Nebulizers and Vaporizers; D011208:Powders; D011282:Pregnenediones / Q000008:administration & dosage*
chemical_list: D001993:Bronchodilator Agents; D011208:Powders; D011282:Pregnenediones; D019819:Budesonide