[The appearance of antinucleosome antibodies precedes that of anti-double-stranded DNA and anti-histones in murine lupus].
Collected samples serum of 30 MRL lpr/lpr and 15 MRL MP +/+ were tested by ELISA on purified mononucleosomes and its individual components, dsDNA and histones. Anti-mononucleosome antibodies can be detected as early as 10 and 23 week of age for MRL lpr/lpr and MP +/+, respectively, and arose before anti-dsDNA and anti-histone antibodies.
Amoura
Z
Z
Inserm U25, hôpital Necker, Paris.
Chabre
H
H
Bach
J F
JF
Jacob
L
L
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D004247:DNA / Q000276:immunology; D006657:Histones / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D009707:Nucleosomes / Q000276:immunology*
D000974:Antibodies, Antinuclear; D006657:Histones; D009707:Nucleosomes; D004247:DNA
L'apparition des anticorps anti-nucléosome précède celle des anti-DNA double brin et des anti-histones au cours du lupus murin.