title: Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats.
abstract: 1. Lipoperoxidation (LPx) and glutathione peroxidase (GPx) activity were measured in kidney, liver, heart, lung, brain and testis from control and puromycin aminonucleoside (PAN) injected rats on days 1-6, 8, 10, 16 and 22 after vehicle or PAN injection. 2. PAN-injected rats developed proteinuria on day 3. 3. In PAN-injected rats: (a) LPx increased in kidney, liver, lung, brain and testis before day 3 and in heart on day 3; (b) GPx activity increased in kidney, liver, heart, lung and testis and diminished in brain on day 3 or after.
authors.affiliation: Department of Nephrology and Mineral Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México D.F., Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Pedraza-Chaverri
authors.forename: A E
authors.initials: AE
authors.lastname: Arévalo
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D007019:Hypoproteinemia / Q000139:chemically induced; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D011507:Proteinuria / Q000139:chemically induced; D011692:Puromycin Aminonucleoside / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects / Q000201:enzymology; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D011692:Puromycin Aminonucleoside; D005979:Glutathione Peroxidase