[Biological tests in sarcoidosis: contribution to diagnosis and surveillance].
No single laboratory examination is diagnostic. On the other hand, such examinations support the diagnosis and aid in management of treated patients. In the serum, there is lymphopenia with a lowered CD4/CD8 ratio. An increase in beta 2-microglobulin and in the soluble IL-2 receptor reflect T lymphocyte activation. A classic observation is hypercalcaemia with hypercalciuria. The increase in angiotensin I converting enzyme reflects the body granulomatous mass. The results of bronchoalveolar lavage show the characteristics of the alveolitis associated with granulomatosis, accumulation of CD4+ T lymphocytes and activated alveolar macrophages. In practice, biochemical anomalies are of interest in the follow-up of treated patients.
Padovani
M
M
Service de pneumologie et immuno-allergologie, hôpital Calmette, CHRU, Lille.
Tillie-Leblond
I
I
Wallaert
B
B
D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D019411:Clinical Laboratory Techniques; D012507:Sarcoidosis / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D013997:Time Factors
Examens biologiques dans la sarcoïdose: apport au diagnostic et à la surveillance.