Anxiolytic effect of neuropeptide FMRFamide in rats.
Central administration of FMRFamide in rats dose dependently increased the duration of time spent in the open arm of an elevated plus maze and enhanced the number of drink contacts in the thirsty rat conflict test. Similarly in the social interaction test, animals pretreated with FMRFamide spent sufficient time in active social interaction as compared to controls. Neuropeptide FMRFamide antagonized the anxiogenic effect of yohimbine and enhanced the antianxiety effect of diazepam in rats. The results indicate anxiolytic action of FMRFamide and the mechanism of such an action may involve serotonergic transmission.
Muthal
A V
AV
Department of Pharmaceutical Sciences, Nagpur University Campus, India.
Chopde
C T
CT
D000595:Amino Acid Sequence; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003220:Conflict, Psychological; D004195:Disease Models, Animal; D004326:Drinking / Q000187:drug effects; D019835:FMRFamide; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D012919:Social Behavior
D014151:Anti-Anxiety Agents; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D019835:FMRFamide