title: Cervical carcinoma: determination of recurrent tumor extent versus radiation changes with MR imaging.
abstract: OBJECTIVE
  To evaluate the effectiveness of magnetic resonance (MR) imaging for assessment of the present and extent of tumor recurrence as determined with pathologic and surgical findings.
  
  
  METHODS
  MR findings were retrospectively examined in 37 patients with a history of cervical carcinoma. Inter- and intraobserver variability was analyzed. Surgical or pathologic results were acquired in 34 of these patients; the remaining three patients were clinically followed up for at least 4 years.
  
  
  RESULTS
  MR imaging allowed correct detection of recurrent tumor in 18 of 21 patients who had histologically documented recurrence. It helped correctly exclude recurrent disease in 15 of 16 patients. Sensitivity and specificity for detection of recurrence was 86% and 94%, respectively. Good intra- and interobserver agreement was demonstrated.
  
  
  CONCLUSIONS
  MR imaging is a useful modality for differentiation of recurrent cervical carcinoma from radiation changes. Determination of the extent of recurrence with MR imaging may offer clinical assistance in the selection of optimal therapy.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC.
authors.forename: T M
authors.initials: TM
authors.lastname: Weber
authors.forename: H D
authors.initials: HD
authors.lastname: Sostman
authors.forename: C E
authors.initials: CE
authors.lastname: Spritzer
authors.forename: R L
authors.initials: RL
authors.lastname: Ballard
authors.forename: G A
authors.initials: GA
authors.lastname: Meyer
authors.forename: D L
authors.initials: DL
authors.lastname: Clark-Pearson
authors.forename: J T
authors.initials: JT
authors.lastname: Soper
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D015588:Observer Variation; D011832:Radiation Injuries / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy*