[Hyperparathyroidism due to parathyroid carcinoma located in the mediastinum].
Parathyroid gland carcinoma is a rare cause of primary hyperparathyroidism. The authors discuss the case of a 56-year-old man who presented with hypercalcemia and multiple bone lesions suggestive of tumor metastases. Laboratory and radiological investigations revealed primary hyperparathyroidism in a patient with evidence of osteitis fibrosa cystica, sustained by carcinoma of a mediastinal parathyroid gland. Early titration of parathyroid hormone (PTH) levels in all patients with hypercalcemia of unclear cause is important for early diagnosis of cases that are tumor-sustained and prevention of the most severe complications. The role of immunostaining with anti-PTH antibodies in demonstrating parathyroid gland tissue in ectopic and/or non-functioning primary tumors, as well as metastases, is also discussed.
Boddi
W
W
U.O. Medicina III, Policlinico di Careggi, Firenze.
Nozzoli
C
C
Francois
C
C
Amorosi
A
A
Grifoni
S
S
Morettini
A
A
Olivotto
J
J
Berni
G
G
D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000209:etiology; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000209:etiology*; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000175:diagnosis / Q000209:etiology; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis
Iperparatiroidismo da carcinoma delle paratiroidi a sede mediastinica.