Relationship between in vitro metabolism of pyrrolizidine alkaloids and extrahepatic toxicity in vivo.
Huxtable
R J
RJ
Department of Pharmacology, College of Medicine, University of Arizona, Tucson 85724.
Wild
S L
SL
D000818:Animals; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D010947:Plants, Toxic / Q000737:chemistry; D011763:Pyrrolizidine Alkaloids / Q000378:metabolism* / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011763:Pyrrolizidine Alkaloids; D010634:Phenobarbital