title: Lower dose diuretic therapy in the treatment of patients with mild to moderate hypertension.
abstract: Indapamide (Lozol), an indoline antihypertensive drug with diuretic and vasodilating activities, was evaluated in 195 patients with mild to moderate essential hypertension (sitting DBP between 95 and 110 mmHg) in a multicentre, randomised, double-blind, parallel-group design trial. A four week single-blind placebo wash-out period was followed by an eight week double-blind period. Patients were randomised to indapamide 1.25 mg/day or to placebo. The primary efficacy endpoint was the mean change in sitting DBP from baseline to week 8. Ninety patients in the placebo group (93%) and 82 patients (84%) in the indapamide group completed the eight weeks of double-blind therapy. Indapamide produced a mean (SE) decrease in sitting DBP of 7.4 (0.63) mmHg (from 100.1 to 92.8 mmHg) compared with a decrease of 3.6 (0.75) mmHg (from 99.6 to 95.8 mmHg) produced by placebo (p < 0.0001). Indapamide and placebo also produced mean decreases in standing DBP of 6.8 (0.75) and 2.8 (0.77) mmHg, respectively (p = 0.0002), in sitting SBP of 11.1 (1.18) and 3.2 (1.35) mmHg, respectively (p = 0.0001) and in standing SBP of 11.4 (1.29) and 4.0 (1.43) mmHg, respectively (P = 0.0002). Reduction in BP of > or = 10 mmHg or to a DBP of < or = 90 mmHg was more frequent (P = 0.0005) among indapamide (46.6%) compared with placebo (23.7%) treated patients. During the eight week double-blind treatment period, incidence rates for all adverse experiences and for drug-related adverse experiences were similar between the two treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hypertension Research Centre, Emory University School of Medicine, Decatur, GA 30030.
authors.forename: W D
authors.initials: WD
authors.lastname: Hall
authors.forename: M A
authors.initials: MA
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Ferdinand
authors.forename: W
authors.initials: W
authors.lastname: Flamenbaum
authors.forename: T
authors.initials: T
authors.lastname: Marbury
authors.forename: A K
authors.initials: AK
authors.lastname: Jain
authors.forename: D
authors.initials: D
authors.lastname: Weidler
authors.forename: R
authors.initials: R
authors.lastname: Weiss
authors.forename: J
authors.initials: J
authors.lastname: Herron
authors.forename: J
authors.initials: J
authors.lastname: Codispoti
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007190:Indapamide / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D007190:Indapamide