title: Dermatophilosis in sheep: first report in Italy, experimental reproduction and evaluation of immune response.
abstract: A severe exudative-crustous and proliferous dermatitis in a 2 year old sheep caused by Dermatophilus congolensis (observed for the first time in Italy), is reported. The disease was reproduced experimentally in sheep, goats, rabbits and guinea pigs, whose skin was treated in different ways before infection. E.L.I.S.A. and Immunoblotting tests carried out in experimentally infected sheep, showed the antigenic complexity of the pathogen and the existence of cross-immunity to the protein components. Intradermoreaction tests were carried out in all animals. The development of a positive reaction only in rabbits and guinea pigs, confirmed that these animals have a cellular immunity against Dermatophilus congolensis.
authors.affiliation: Istituto di Patologia Generale e Anatomia Patologica Veterinaria, Università degli Studi di Sassari.
authors.forename: A
authors.initials: A
authors.lastname: Leoni
authors.forename: M
authors.initials: M
authors.lastname: Fadda
authors.forename: A M
authors.initials: AM
authors.lastname: Nieddu
authors.forename: M
authors.initials: M
authors.lastname: Pittau
authors.forename: E
authors.initials: E
authors.lastname: Sanna
authors.forename: S
authors.initials: S
authors.lastname: Pirino
authors.forename: A
authors.initials: A
authors.lastname: Contini
mesh_terms: D000192:Actinomycetales / Q000276:immunology; D000193:Actinomycetales Infections / Q000276:immunology* / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood; D003872:Dermatitis / Q000276:immunology* / Q000473:pathology / Q000662:veterinary*; D006041:Goats; D006168:Guinea Pigs; D051379:Mice; D011817:Rabbits; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: D000908:Antibodies, Fungal