title: Modulation defect of sodium pump evidenced in diabetic patients by a microcalorimetric study.
abstract: Sodium pump activity of intact erythrocytes in their own plasma was measured by microcalorimetry in 41 healthy subjects and 35 insulin-dependent diabetic patients. Results show that modulation of the sodium pump is altered in diabetic patients. Addition of insulin increases functioning of the Na(+)-K+ pump in controls but has no effect in diabetic patients. These subjects show a slower response of the Na(+)-K+ pump to the inhibitory effect of ouabain. Cross-incubation experiments suggest that these findings may be explained by the existence of a plasmatic factor that impairs the modulation of the sodium pump in diabetic patients.
authors.affiliation: Laboratoire de Biophysique, Faculté de Pharmacie, Université d'Aix-Marseille II, France.
authors.forename: T
authors.initials: T
authors.lastname: Issautier
authors.forename: H
authors.initials: H
authors.lastname: Kovacic
authors.forename: P
authors.initials: P
authors.lastname: Gallice
authors.forename: D
authors.initials: D
authors.lastname: Raccah
authors.forename: P
authors.initials: P
authors.lastname: Vague
authors.forename: A
authors.initials: A
authors.lastname: Crevat
mesh_terms: D000328:Adult; D002151:Calorimetry; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008875:Middle Aged; D010042:Ouabain / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
chemical_list: D007328:Insulin; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase