title: [State of shock during acute meprobamate poisoning. 6 cases].
abstract: The prognosis of acute meprobamate poisoning is related to shock whose haemodynamic mechanism remains obscure. We report the results of a retrospective study of six patients with meprobamate poisoning associated with shock and explored by a right heart catheterization. The age of the patients, five women and one man, ranged from 36 to 57 years. Five patients had also ingested other psychotropic drugs. A haemodynamic investigation was performed at admission to the ICU and three hours later, under treatment. Vasoplegia was the predominant feature. A myocardial dysfunction was sometimes associated, which can be explained by a moderate hypothermia. According to these results, we suggest that prior to right heart catheterization, the treatment should include inotropic and alphamimetic agents and that vascular filling should be cautious.
authors.affiliation: Service de Réanimation Médicale, CHU Bretonneau, Tours.
authors.forename: C
authors.initials: C
authors.lastname: Landier
authors.forename: R
authors.initials: R
authors.lastname: Lanotte
authors.forename: A
authors.initials: A
authors.lastname: Legras
authors.forename: P F
authors.initials: PF
authors.lastname: Dequin
authors.forename: D
authors.initials: D
authors.lastname: Perrotin
mesh_terms: D000328:Adult; D005260:Female; D015600:Glasgow Coma Scale; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008620:Meprobamate / Q000506:poisoning*; D008875:Middle Aged; D012189:Retrospective Studies; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000503:physiopathology; D013406:Suicide, Attempted
chemical_list: D008620:Meprobamate
vernacular_title: Etat de choc lors de l'intoxication aiguë par le méprobamate. Six observations.