[Secondary structure of the M2 protein of influenza type A virus and its role in forming resistance to rimantadine and deitiforin].
Studies of the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow a purposeful design of new compounds with a broad spectrum of antiviral activity and evoking no resistance. In this work the nucleotide sequence of rimantadine- and deytiforine-resistant influenza A strain Leningrad/156/83 (H3N2) was compared with that of A/Victoria/35/72. The influence of aminoacid substitutions in the M2 protein on its secondary structure in the membrane and its role in resistance development was shown.
Kiselev
O I
OI
Mishin
V P
VP
Eroshkin
V I
VI
Kozeletskaia
K N
KN
Usova
E V
EV
Rudenko
V I
VI
Chupakhin
O N
ON
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000494:pharmacology*; D001483:Base Sequence; D017931:DNA Primers; D004351:Drug Resistance; D009980:Influenza A virus / Q000737:chemistry*; D008969:Molecular Sequence Data; D009930:Organic Chemicals; D017433:Protein Structure, Secondary; D012299:Rimantadine / Q000494:pharmacology*; D014763:Viral Matrix Proteins / Q000737:chemistry* / Q000502:physiology; D000086082:Viroporin Proteins
D000998:Antiviral Agents; D017931:DNA Primers; D009930:Organic Chemicals; D012299:Rimantadine; D014763:Viral Matrix Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C060204:deitiforin
Vtorichnaia struktura belka M2 virusa grippa tipa A i ego rol' v formirovanii rezistentnosti k remantadinu i deitiforinu.