Effects of ulinastatin on polymorphonuclear leukocyte elastase and interleukin 6 levels after hepatectomy.
Eight patients undergoing hepatectomy received 15 x 10(4) U of ulinastatin during and after surgery and then twice daily for 4 days, and 11 hepatectomized patients served as untreated controls. Between-group differences in age, duration of surgery, volume of blood loss and transfusion, weight of resected liver, and results of preoperative liver function tests were not significant. On postoperative day 1, mean (+/- SD) polymorphonuclear leukocyte elastase levels were significantly lower in the treated patients than in the controls (310 +/- 69 micrograms/L vs 519 +/- 382 micrograms/L; P < 0.05); interleukin 6 levels also tended to be lower in the treated patients than in controls (42.4 +/- 34.0 pg/mL vs 63.3 +/- 43.1 pg/mL). The results indicate that ulinastatin has beneficial effects on host defenses after surgery.
Hamazaki
K
K
First Department of Surgery, Okayama University Medical School, Japan.
Matsubara
N
N
Yunoki
Y
Y
Mori
M
M
Mimura
H
H
Orita
K
K
D000410:Alanine Transaminase / Q000097:blood; D006023:Glycoproteins / Q000276:immunology / Q000627:therapeutic use*; D006498:Hepatectomy; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D019272:Leukocyte Elastase / Q000097:blood*; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000097:blood*; D011184:Postoperative Period; D014361:Trypsin Inhibitors / Q000276:immunology / Q000627:therapeutic use*
D006023:Glycoproteins; D015850:Interleukin-6; D014361:Trypsin Inhibitors; D000410:Alanine Transaminase; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; C028665:urinastatin