title: Growth temperature reversibly modulates the virulence of Legionella pneumophila.
abstract: In chemostat culture, the virulence of two strains of Legionella pneumophila was shown to be significantly (P < 0.05) reduced when the culture temperature was lowered from 37 to 24 degrees C. This modulation was reversed by returning the temperature to 37 degrees C, which resulted in a statistically significant (P < 0.05) increase in virulence.
authors.affiliation: Division of Pathology, Public Health Laboratory Service Centre for Applied Microbiology & Research, Porton Down, Salisbury, Wiltshire, United Kingdom.
authors.forename: W S
authors.initials: WS
authors.lastname: Mauchline
authors.forename: B W
authors.initials: BW
authors.lastname: James
authors.forename: R B
authors.initials: RB
authors.lastname: Fitzgeorge
authors.forename: P J
authors.initials: PJ
authors.lastname: Dennis
authors.forename: C W
authors.initials: CW
authors.lastname: Keevil
mesh_terms: D000818:Animals; D002455:Cell Division; D006168:Guinea Pigs; D006358:Hot Temperature; D016952:Legionella pneumophila / Q000254:growth & development / Q000472:pathogenicity*; D007928:Lethal Dose 50; D014774:Virulence