HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families.
The role of HLA class II alleles in genetic predisposition to insulin dependent diabetes mellitus (IDDM) was examined by PCR/oligonucleotide probe typing of 42 Mexican-American IDDM families derived from Hispanic Caucasians and Native Americans. All high risk haplotypes (HLA-DR3 and DR4) were of European origin while the most strongly protective haplotype (DRB1*1402) was Native American. Of the 16 DR-DQ DR4 haplotypes identified, only those bearing DQB1*0302 conferred risk; the DRB1 allele, however, also markedly influenced IDDM risk. The general pattern of neutral and protective haplotypes indicates that the presence of Asp-57 in the HLA-DQ beta chain does not confer IDDM protection per se and indicates that both DRB1 and DQB1 influence IDDM susceptibility as well as protection.
Erlich
H A
HA
Department of Human Genetics, Roche Molecular Systems, Inc., Alameda, California 94501.
Zeidler
A
A
Chang
J
J
Shaw
S
S
Raffel
L J
LJ
Klitz
W
W
Beshkov
Y
Y
Costin
G
G
Pressman
S
S
Bugawan
T
T
D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D017058:Mexican Americans / Q000235:genetics*; D008800:Mexico / Q000208:ethnology; D010375:Pedigree; D016133:Polymerase Chain Reaction; D012016:Reference Values; D012307:Risk Factors; D014481:United States; D044465:White People / Q000235:genetics
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II