Pulmonary hair embolism in monkeys.
Among 184 rhesus and cynomolgus monkeys treated daily for 28 consecutive days by injection into cephalic or saphenous veins, 14 animals (7.6%) had pulmonary emboli with fragments of skin or hair in arterial thrombi or in giant cell granulomas. 167 monkeys (91%) showed lesions at the site of injection, predominantly bleeding and chronic periphlebitis, whereas particles of skin or hair were rare around the veins (2.2%). 2 or 8 weeks after cessation of treatment no pulmonary lesions were observed and healing at the sites of injection was nearly completed in 11 of 12 monkeys allowed to recover.
Kast
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Boehringer Ingelheim GmbH, Germany.
D000818:Animals; D005260:Female; D005548:Foreign-Body Migration / Q000473:pathology / Q000662:veterinary*; D006197:Hair; D007275:Injections, Intravenous / Q000009:adverse effects / Q000662:veterinary; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008992:Monkey Diseases / Q000473:pathology*; D011655:Pulmonary Embolism / Q000473:pathology / Q000662:veterinary*