Prenatally diagnosed non-immune hydrops caused by congenital transient leukaemia.
Congenital transient leukaemia (CTL) is a haematological disorder characterized by proliferation of myeloblasts within the bone marrow and peripheral blood of affected newborns. Infants with Down syndrome are most frequently affected and although the disorder can result in fetal death due to hydrops, it typically resolves spontaneously after birth. We present a case of prenatally diagnosed fetal hydrops accompanied by splenomegaly and an enlarged, echogenic liver in a fetus identified with CTL after birth.
Donnenfeld
A E
AE
Department of Obstetrics and Gynecology, Pennsylvania Hospital. Philadelphia 19107.
Scott
S C
SC
Henselder-Kimmel
M
M
Dampier
C D
CD
D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging; D006400:Hematocrit; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging* / Q000209:etiology*; D007231:Infant, Newborn; D007938:Leukemia / Q000150:complications / Q000151:congenital* / Q000473:pathology; D007958:Leukocyte Count; D008099:Liver / Q000000981:diagnostic imaging / Q000196:embryology; D011247:Pregnancy; D013154:Spleen / Q000000981:diagnostic imaging / Q000196:embryology; D013163:Splenomegaly; D016216:Ultrasonography, Prenatal