Synthesis of 1-methyl-2,3-dimethyl-N(isopropyl)carbamates-4,5-dihydro-7-R'- 8-R-1H-benzo[g]indoles and evaluation of in vitro anticancer activity.
The synthesis of 7-mono or 7,8-disubstituted 4,5-dihydro-1-methyl-1H- benzo[g]indoles bearing a methyl-N-isopropylcarbamate group in position 2 or 2,3 of the pyrrole ring is described, in order to evaluate in vitro, anticancer activity. The preliminary results of this screening at the NCI of Bethesda showed a certain cellular subpanel selectivity between 10(-5) and 10(-4) molar concentrations.
Pinna
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Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.
Pirisi
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Paglietti
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles