title: Pathogenesis of idiopathic scoliosis: SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis.
abstract: We studied somatosensory evoked potentials (SEPs) in 20 chickens with experimentally induced scoliosis after pinealectomy and in 100 patients with idiopathic scoliosis. We also studied 20 chickens without scoliosis and 20 healthy youngsters. In the chickens, SEPs after leg stimulation was significantly delayed in the scoliosis group compared to the controls. In patients, the latency of cortical potential (N37) after stimulation of tibial nerve was longer in the scoliosis group than in the controls. Our findings in both experimental and clinical studies strongly support the hypothesis that idiopathic scoliosis results from dysfunction in the central nervous system. The type of SEPs abnormalities described in idiopathic scoliosis suggest a pathology from the midbrain to the cortex.
authors.affiliation: Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Machida
authors.forename: J
authors.initials: J
authors.lastname: Dubousset
authors.forename: Y
authors.initials: Y
authors.lastname: Imamura
authors.forename: T
authors.initials: T
authors.lastname: Iwaya
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: J
authors.initials: J
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Toriyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D002645:Chickens; D002648:Child; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000503:physiopathology; D010870:Pineal Gland / Q000601:surgery; D011859:Radiography; D011930:Reaction Time; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013979:Tibial Nerve / Q000503:physiopathology