Diagnostic and prognostic role of plasma and urinary sialic acid in human carcinoma of uterine cervix.
In different stages of carcinoma of uterine cervix, the plasma total sialic acid (TSA), lipid bound sialic acid (LSA) and urinary sialic acid levels were studied before and after radiation treatment. Glycocomponents of glycoproteins were found to be increased progressively as the disease advances. The increased levels of glycocomponents were found to be decreased to near normal levels after radiotherapy. This may be a better indicator of the disease in conjunction with the studies of cervical smear rather than the latter alone.
Balasubramaniyan
N
N
Department of Biochemistry, University of Madras, India.
Subramanian
S
S
Sekar
N
N
Bhuvarahamurthy
V
V
Govindasamy
S
S
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood / Q000652:urine; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006017:Glycolipids / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D012794:Sialic Acids / Q000032:analysis* / Q000097:blood / Q000652:urine; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy
D014408:Biomarkers, Tumor; D006017:Glycolipids; D006023:Glycoproteins; D009363:Neoplasm Proteins; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid