Transplantation of cholinergic-rich spinal tissue from spontaneously aborted human fetuses into a rodent model of Alzheimer's disease.
The results from this study provided the first piece of evidence that intrahippocampal transplants of cholinergic-rich spinal grafts derived from a human fetus can ameliorate the performance of fornix lesioned rats in both spatial reference memory and spatial navigation tasks. Although many questions remain to be answered, these results point to the therapeutic potential of human fetus-derived cholinergic-rich grafts in treating spatial memory impairments.
Li
Y J
YJ
Department of Neurosurgery, University of Minnesota Medical School, Minneapolis.
Conrad
J A
JA
Low
W C
WC
D000022:Abortion, Spontaneous; D000109:Acetylcholine / Q000502:physiology; D000544:Alzheimer Disease / Q000628:therapy*; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D018782:Maze Learning; D009416:Nerve Regeneration; D011247:Pregnancy; D051381:Rats; D013116:Spinal Cord / Q000502:physiology / Q000637:transplantation*; D013997:Time Factors; D014183:Transplantation, Heterologous
D000109:Acetylcholine