[Acute hepatopathy compatible with Reye's syndrome in 3 children treated by chemotherapy].
BACKGROUND
Chemotherapy for malignant diseases sometimes leads to hepatic toxicity. Reye's syndrome has not been described in such a situation.


METHODS
Three children, 4, 5 and 6 years-old, were treated for lymphoma or acute lymphoblastic leukemia. They were given polychemotherapy including drugs that were not potentially hepatotoxic. During remission, they suddenly developed manifestations such as neurologic disturbances, hepatomegaly, increased activity of liver enzymes, and microvesicular steatosis. These disturbances were consistent with the diagnostic criteria for Reye's syndrome recommended by the Centers for Disease Control. Factors such as viral infection, salicylate administration, primary metabolic disorder were not present. One child died and the other two recovered completely.


CONCLUSIONS
Patients given chemotherapy, even though the relationship between them remains to be determined, may develop manifestations compatible with a diagnosis of Reye's syndrome.
Rubie
H
H
Unité d'hémato-oncologie pédiatrique, CHU Purpan, Toulouse, France.
Guillot
S
S
Netter
J C
JC
Le Tallec
C
C
Voigt
J J
JJ
Claeyssens
S
S
Olives
J P
JP
Regnier
C
C
Robert
A
A
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012202:Reye Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D012878:Skin Neoplasms / Q000188:drug therapy
Hépatopathie aiguë compatible avec un syndrome de Reye chez trois enfants traités par chimiothérapie.