title: Lanthanide ions for the first non-enzymatic formation of adenosine 3',5'-cyclic monophosphate from adenosine triphosphate under physiological conditions.
abstract: Adenosine 3',5'-cyclic monophosphate (cAMP) is formed from adenosine triphosphate at pH 8 and 50 degrees C by use of lanthanide ions. Pr3+ and La3+ are the most active. The cAMP formation is more efficient at higher pH, where the mixture is made homogeneous by the addition of beta-cyclodextrin. The potential functioning of lanthanide ions as the catalytic center of an artificial adenylate cyclase is indicated.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Yajima
authors.forename: J
authors.initials: J
authors.lastname: Sumaoka
authors.forename: S
authors.initials: S
authors.lastname: Miyama
authors.forename: M
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D000242:Cyclic AMP / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D008674:Metals, Rare Earth / Q000737:chemistry*
chemical_list: D008674:Metals, Rare Earth; D000255:Adenosine Triphosphate; D000242:Cyclic AMP