Prostaglandin E1 as treatment for erectile failure in elderly men.
OBJECTIVE
To determine the efficacy of intracavernosal injection of prostaglandin E1 (alprostadil) in elderly men with erectile failure.


METHODS
Prospective study.


METHODS
Outpatients at a university-affiliated VA Medical Center.


METHODS
Ten subjects aged 65 years and older with duration of erectile failure of 6 months or longer.


METHODS
Subjects received intracavernosal injections of prostaglandin E1 in the office and self-administered intracavernosal prostaglandin E1 at home.


METHODS
Penile rigidity was measured by palpation and by the Rigiscan rigidity monitor.


RESULTS
Intracavernosal injection of prostaglandin E1 produced erections adequate for intercourse in 9 of the 10 subjects. Attempts at intercourse were rated satisfactory by two-thirds of the subjects and their spouses.


CONCLUSIONS
Intracavernosal injection of prostaglandin E1 is safe and effective for erectile failure in elderly men.
Godschalk
M F
MF
Division of Geriatrics, Medical College of Virginia, Richmond.
Chen
J
J
Katz
P G
PG
Mulligan
T
T
D000367:Age Factors; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007267:Injections; D008297:Male; D008991:Monitoring, Physiologic; D009819:Office Visits; D010173:Palpation; D017060:Patient Satisfaction; D010413:Penis; D011446:Prospective Studies; D012646:Self Administration
D000527:Alprostadil