HIV-2 EHO isolate has a divergent envelope gene and induces single cell killing by apoptosis.
The human immunodeficiency virus type 2 (HIV-2)-related isolate, referred to as HIV-2 EHO, has been isolated from an Ivory Coast patient with acquired immunodeficiency syndrome (AIDS). Infection of CD4 expressing cells with this highly infectious virus mediates a cytopathic effect characterized by single-cell killing as a consequence of apoptosis. Nucleotide sequence analysis of the HIV-2 EHO genome revealed a significant degree of divergence of its envelope gene from that of other known HIV-2 strains. This divergence for the deduced amino acid sequence corresponding to the extracellular envelope glycoprotein was 26 to 30%. These unique genetic and biological properties suggest that the HIV-2 EHO isolate is a distinct prototype in the HIV-2 family.
Rey-Cuille
M A
MA
Department of AIDS and Retroviruses, UA CNRS 1157, Institut Pasteur, Paris, France.
Galabru
J
J
Laurent-Crawford
A
A
Krust
B
B
Montagnier
L
L
Hovanessian
A G
AG
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000595:Amino Acid Sequence; D017209:Apoptosis; D002478:Cells, Cultured; D015752:Genes, env; D014644:Genetic Variation; D015726:Giant Cells / Q000382:microbiology; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015498:HIV-2 / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D015699:HIV Envelope Protein gp120