Isolation and characterization of new 18-membered macrolides FD-891 and FD-892.
New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture Japan. They induce morphological changes of HL-60 cells at low concentration below IC50s and have cytocidal activity against in vitro tumor cell lines. FD-891 showed 2 approximately 7 times stronger activity than doxorubicin whereas FD-892 was 20 approximately 100 fold weaker than FD-891 and doxorubicin.
Seki-Asano
M
M
Dept. of Applied Biology, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Okazaki
T
T
Yamagishi
M
M
Sakai
N
N
Hanada
K
K
Mizoue
K
K
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D018942:Macrolides; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides; C091118:FD 891; C091119:FD 892; D000251:Adenosine Triphosphatases