Tumor development and apoptosis.
Apoptosis or other types of active cell death may play a major role at various stages of carcinogenesis. Active cell death can be induced, by internal and exogenous signals, in preneoplastic, neoplastic and even malignant cells. It may reverse the effects of initiation and promotion and may lead to tumor regression. Conversely tumor promoters may inhibit active cell death in preneoplastic cells and thereby accelerate cancer development.
Schulte-Hermann
R
R
Institut für Tumorbiologie-Krebsforschung, Vienna, Austria.
Grasl-Kraupp
B
B
Bursch
W
W
D000818:Animals; D017209:Apoptosis; D002999:Clone Cells; D006801:Humans; D008099:Liver / Q000166:cytology; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D009374:Neoplasms, Experimental / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology