title: Effect of metallothionein I on mitochondrial oxygen consumption.
abstract: The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied. Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT. The MT effect was concentration dependent. No evidence was found for the provision by MT of an alternate pathway to oxygen.
authors.affiliation: University of Maryland School of Medicine, Department of Surgery, Baltimore.
authors.forename: C O
authors.initials: CO
authors.lastname: Simpkins
authors.forename: H L
authors.initials: HL
authors.lastname: Zhao
authors.forename: C A
authors.initials: CA
authors.lastname: Torrence
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004579:Electron Transport / Q000187:drug effects; D008297:Male; D008668:Metallothionein / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D017967:Zinc Compounds / Q000494:pharmacology
chemical_list: D002712:Chlorides; D013386:Succinates; D017967:Zinc Compounds; D002104:Cadmium; D000244:Adenosine Diphosphate; C016837:zinc chloride; D008668:Metallothionein; D019802:Succinic Acid; D019256:Cadmium Chloride