title: Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase.
abstract: A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.
authors.affiliation: Laboratory of Drug Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Van Overbeke
authors.forename: W
authors.initials: W
authors.lastname: Baeyens
authors.forename: W
authors.initials: W
authors.lastname: Van den Bossche
authors.forename: C
authors.initials: C
authors.lastname: Dewaele
mesh_terms: D000577:Amides / Q000737:chemistry / Q000302:isolation & purification*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification*; D001565:Benzoates; D002482:Cellulose / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D007202:Indicators and Reagents; D010666:Phenylpropionates; C090722:tris(4-methylbenzoate)cellulose; D002482:Cellulose