[The intensification of the therapy of chronic myeloleukemia by taking into account the factors prognostic of the course of the disease].
A multifactorial computer analysis of current modalities in relevant treatment performed for 208 patients with chronic myeloid leukemia (CML) has revealed a close relationship between the set of unfavourable factors upon the diagnosis, choice of treatment and the patients' survival. For groups of patients with a standard CML risk it is preferable to use monotherapy. More intensive treatment (polychemotherapy) is indicated in the disease progression. The patients at moderate and high CML risk are recommended to be treated intensively (polychemotherapy, polychemotherapy+leukocytapheresis, splenectomy) from the start, that is upon CML diagnosis. The above approach promotes longer survival of CML patients.
Khoroshko
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D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003422:Critical Care / Q000706:statistics & numerical data; D018450:Disease Progression; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
Intensifikatsiia terapii khronicheskogo mieloleĭkoza s uchetom faktorov prognozirovaniia techeniia bolezni.