[Inhibition of mexiletine on sodium current in dorsal root ganglion neurons of rats].
Using whole-cell configuration of patch clamp technique we found that mexiletine (Mex) reversibly inhibited the sodium current in a voltage- and use-dependent manner in cultured dorsal root ganglion (DRG) neurons. The threshold concentration of Mex was 5 mumol.L-1. The inhibitory action heightened with increasing concentrations of Mex. Complete inhibition was achieved at 150 mumol.L-1 and the 50% inhibition concentration was 31 mumol.L-1. It is suggested that the inhibition of Mex on sodium current in neurons may be one of the mechanisms of its anti-ischemic and anti-anoxic effects on the neuron.
Zhang
X F
XF
Beijing Neurosurgical Institute, China.
Wang
T Y
TY
Zhang
L
L
D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D005727:Ganglia, Spinal / Q000187:drug effects*; D008297:Male; D008801:Mexiletine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects*
D015222:Sodium Channels; D008801:Mexiletine