Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.
Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.
Takahashi
C
C
Osaka University of Pharmaceutical Sciences, Japan.
Numata
A
A
Matsumura
E
E
Minoura
K
K
Eto
H
H
Shingu
T
T
Ito
T
T
Hasegawa
T
T
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D010879:Piperazines; C091120:leptosin I