title: The effect of food on the interaction of ofloxacin with sucralfate in healthy volunteers.
abstract: We have studied the effect of food on the interaction of ofloxacin with sucralfate. Six healthy men took a single oral dose of ofloxacin (200 mg) on 4 occasions: alone after overnight fasting or after breakfast (non-fasting), and with sucralfate fasting or non-fasting. There were no significant differences in the plasma concentration-time profiles of ofloxacin after ofloxacin alone between fasting and non-fasting conditions. On the other hand, the peak plasma concentration and AUC of ofloxacin after co-administration with sucralfate while fasting fell by 70 and 61% compared with ofloxacin alone; the changes non-fasting were 39 and 31% respectively. The interaction of ofloxacin with sucralfate was markedly reduced by food, but still could not be disregarded.
authors.affiliation: Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Matsuse
authors.forename: H
authors.initials: H
authors.lastname: Kotaki
authors.forename: T
authors.initials: T
authors.lastname: Seino
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: H
authors.initials: H
authors.lastname: Orimo
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Iga
mesh_terms: D000328:Adult; D004347:Drug Interactions; D005215:Fasting / Q000378:metabolism; D018565:Food-Drug Interactions; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics*; D013392:Sucralfate / Q000494:pharmacology*
chemical_list: D013392:Sucralfate; D015242:Ofloxacin