[Sodium ferulate alleviated paracetamol-induced liver toxicity in mice].
Sodium ferulate (SF) is one of the effective components of Angelica sinensis Diels. Pretreatment with SF (100 mg.kg-1 ig, qd x 10 d) inhibited the activity of serum alanine aminotransferase, prevented the depletion of liver glycogen and glutathione, increased the liver homogenate and microsomal glutathione S-transferase activities, and reduced the malondialdehyde content, the membrane fluidity of liver microsome and the mitochondria in paracetamol (130 mg.kg-1, ip)-induced liver toxicity in mice. These results demonstrated the hepato-protective action of SF in mice.
Wang
H
H
Department of Pharmacology, Hubei Medical University, Wuhan, China.
Peng
R X
RX
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000378:metabolism*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D003373:Coumaric Acids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism
D003373:Coumaric Acids; D008112:Liver Glycogen; D000082:Acetaminophen; D008315:Malondialdehyde; C004999:ferulic acid; D005982:Glutathione Transferase; D000410:Alanine Transaminase; D005978:Glutathione