title: Clinical features and diagnostic criteria of depression in Down's syndrome.
abstract: BACKGROUND
  Depression occurs commonly in people with Down's syndrome, although there is little published about this association. This study explores the limitations of Diagnostic Criteria for Research, based on ICD-10 (DCR) and DSM-III-R depressive criteria.
  
  
  METHODS
  Case not examination identified 42 adults with Down's syndrome who have sustained 56 depressive episodes. The clinical features are reported.
  
  
  RESULTS
  All episodes were diagnosed as depression. DSM-III-R criteria for major depressive episode were met by 50% of the episodes. DCR for depressive episode of at least mild severity were fulfilled by 68%.
  
  
  CONCLUSIONS
  These criteria were unduly restrictive for this group. Commonly occurring symptoms are not included in the criteria, while certain criteria items never occurred. Criteria should be modified to facilitate future research.
authors.affiliation: Frith Hospital, University of Leicester.
authors.forename: S A
authors.initials: SA
authors.lastname: Cooper
authors.forename: R A
authors.initials: RA
authors.lastname: Collacott
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D004314:Down Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D004739:England; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology; D011569:Psychiatric Status Rating Scales