Clear cell ("sugar") tumor of the lung is a lesion strictly related to angiomyolipoma--the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC).
We report a comparative study of 3 clear cell tumors of the lung (CCTL) and 3 angiomyolipomas (AML) of the kidney. Morphological analysis shows that the cells of CCTL are identical to the perivascular epithelioid component of AML. Phenotypically they both consistently expressed melanoma-associated antigens recognized by Moabs HMB45 and HMSA-1, while they were negative for HMSA-5. A minority of cells also expressed S-100 protein, vimentin and actin. In addition, one case of CCTL showed mature adipose tissue entrapped in the proliferation, thus suggesting an intermediate form between CCTL and AML. Based on morphological and phenotypical similarities, it is suggested that CCTL and AML belong to the same family of lesions, characterized by the presence of a peculiar muscle cell, expressing different melanoma-associated antigens.
Bonetti
F
F
Istituto di Anatomia Patologica, Università di Verona, Italy.
Pea
M
M
Martignoni
G
G
Doglioni
C
C
Zamboni
G
G
Capelli
P
P
Rimondi
P
P
Andrion
A
A
D000328:Adult; D018207:Angiomyolipoma / Q000737:chemistry / Q000473:pathology*; D001808:Blood Vessels / Q000166:cytology; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006003:Glycogen / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology*; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D006003:Glycogen