[Determination of pseudoephedrine in human plasma by gas chromatography with a mass selective detector (GC-MSD)].
A specific and sensitive method has been established for the analysis of pseudoephedrine (PE) in human plasma by gas chromatography with a mass selective detector (GC-MSD). PE and ephedrine (E, internal standard) reacted with trifluoroacetic anhydride (TFAA) and the derivatives were separated by a HP-5 capillary column. PE-TFA and E-TFA were quantitatively measured by selected ion monitoring (m/z = 154). The detection limits for E and PE were 1 ng/ml plasma. The recoveries were about 99%.
Yang
L L
LL
Nanjing General Hospital of PLA.
Tu
X D
XD
D003692:Delayed-Action Preparations; D004809:Ephedrine / Q000008:administration & dosage / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans
D003692:Delayed-Action Preparations; D004809:Ephedrine