title: Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK).
abstract: The introduction of screening for hepatitis C virus (HCV) by the National Blood Transfusion Service identified donors who had acquired HCV infection. We undertook a case-control study amongst blood donors in the Trent Region to determine risks for HCV infection. A total of 74 blood donors confirmed positive for hepatitis C infection and 150 age, sex and donor venue matched controls were included in the study. Fifty-three percent of hepatitis C infected blood donors reported previous use of injected drugs compared to no controls; relative risk (RR) not estimatable (lower limit 95% CI = 20). Other risk factors were a history of: receipt of a blood transfusion or blood products RR = 3.6 (95% CI 1.5-8.3), having been a 'health care worker' RR = 2.8 (95% CI 1.1-7.6), tattooing RR = 3.3 (95% CI 1.2-8.7), and an association with having been born abroad RR = 3.2 (95% CI 1.1-9.5). No risk was shown for a history of multiple sexual partners, ear piercing or acupuncture. Injecting drug use explains more than 50% of hepatitis C infections in blood donors, a group who are less likely to have injected drugs than the general population.
authors.affiliation: Department of Public Health Medicine, University Hospital, University of Nottingham.
authors.forename: K R
authors.initials: KR
authors.lastname: Neal
authors.forename: D A
authors.initials: DA
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Killey
authors.forename: V
authors.initials: V
authors.lastname: James
mesh_terms: D000328:Adult; D001782:Blood Donors; D016022:Case-Control Studies; D005260:Female; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D008297:Male; D012307:Risk Factors; D012747:Sexual Partners; D015819:Substance Abuse, Intravenous / Q000150:complications*; D065227:Transfusion Reaction; D014195:Travel; D006113:United Kingdom / Q000453:epidemiology