The effect of neonatal immunoregulatory cells and cyclosporine on the heart allograft survival in rats.
Lymphoid neonatal cells from syngeneic donors are able to modulate the reactivity of recipient rats to MHC-incompatible vascular cardiac grafts. The suppressor splenocytes, obtained from one-day-old rats, may enhance the immunosuppressive effect of chronically administered low doses of cyclosporine (CsA).
Skowron-Cendrzak
A
A
Department of Immunology, Polish Academy of Sciences, Krakow.
Garlicki
M
M
Kubera
M
M
D000818:Animals; D000831:Animals, Newborn; D016572:Cyclosporine / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000166:cytology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology
D016572:Cyclosporine