Radiation-induced osteosarcomas of the skull: report of two cases and review of the literature.
Osteosarcoma of the skull as a second neoplasm after radiation therapy is unusual. This neoplasm generally occurs after doses of over 10 Gy. CT, MRI and biopsy are the main diagnostic procedures for this lesion. We report two other cases of osteosarcomas of the skull and review the pertinent literature.
Salvati
M
M
Department of Neurological Sciences, Neurosurgery, La Sapienza University of Rome, Italy.
Cervoni
L
L
Ciappetta
P
P
Raco
A
A
D000236:Adenoma / Q000473:pathology / Q000532:radiotherapy*; D000328:Adult; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000209:etiology* / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects*; D012888:Skull Neoplasms / Q000209:etiology* / Q000601:surgery; D013100:Sphenoid Bone / Q000473:pathology / Q000528:radiation effects*