title: Effect of crude extract of roots of Bredemeyera floribunda Willd. I. Effect on arterial blood pressure and renal excretion in the rat.
abstract: The infusion of the dried roots of Bredemeyera floribunda Willd. is used in Brazilian popular medicine as a potent diuretic, especially in the treatment of hypertension and nephrolithiasis (renal calculi). Intravenous administration of crude root-extract (20-80 mg/kg) to anesthetized rats induces clear dose-dependent and reversible hypotensive responses. At higher doses the extract leads to bradycardia and death. In doses that do not alter the arterial blood pressure, the extract elicited immediate and dose-dependent reversible increase of water, sodium, and potassium renal excretion. The results, apart from indicating that the renal effect of the extract is not due to its systemic hypotensive action, support the folk therapeutic use of the infusion of the root-extract as a diuretic.
authors.affiliation: Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.
authors.forename: L H
authors.initials: LH
authors.lastname: Bevevino
authors.forename: F S
authors.initials: FS
authors.lastname: Vieira
authors.forename: A C
authors.initials: AC
authors.lastname: Cassola
authors.forename: S M
authors.initials: SM
authors.lastname: Sanioto
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001938:Brazil; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine
chemical_list: D010936:Plant Extracts; D012964:Sodium; D011188:Potassium