Effects of some benzodiazepines on glycemia in albino rats.
The acute administration of some benzodiazepines in normoglycemic rats induced only minor changes of the blood glucose levels. In Triton WR-1339 administered rats, the benzodiazepines brought about minor modifications of this parameter. However, in diabetic rats (streptozotocin-induced diabetes), diazepam administered subacutely elicited very significant diminutions of glycemia. This was due, at least partly, to an increase of the glucose uptake by the skeletal muscle.
Cuparencu
B
B
Department of Pharmacology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Horák
J
J
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis*; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013311:Streptozocin / Q000097:blood
D001786:Blood Glucose; D001569:Benzodiazepines; D011092:Polyethylene Glycols; D013311:Streptozocin; D003975:Diazepam; C016811:tyloxapol