title: A patient with multiple myeloma and respiratory insufficiency due to accumulation of paraprotein in the alveolar space.
abstract: We describe a patient with multiple myeloma and respiratory insufficiency. Autopsy revealed accumulation of IgG-kappa paraprotein in the alveolar space. The clinical and pathological presentation are typical for secondary pulmonary alveolar proteinosis. Attention is focussed on the possibility of secondary pulmonary alveolar proteinosis as a cause for dyspnoea in patients with haematological malignancies.
authors.affiliation: Department of Internal Medicine, Sophia Hospital, Zwolle, The Netherlands.
authors.forename: W G
authors.initials: WG
authors.lastname: Meijer
authors.forename: M
authors.initials: M
authors.lastname: Van Marwijk Kooy
authors.forename: B E
authors.initials: BE
authors.lastname: Laddé
mesh_terms: D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010266:Paraproteins / Q000276:immunology / Q000378:metabolism*; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D012131:Respiratory Insufficiency / Q000209:etiology / Q000378:metabolism / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G; D010266:Paraproteins