Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma.
Chromosome studies in a 7-week-old female infant with an intraabdominal malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +der(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appears to be a nonrandom primary cytogenetic abnormality in the congenital or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.
Bernstein
R
R
Division of Human Genetics, College of Medicine, University of California, Irvine.
Zeltzer
P M
PM
Lin
F
F
Carpenter
P M
PM
D002880:Chromosomes, Human, Pair 11; D005260:Female; D005354:Fibrosarcoma / Q000151:congenital / Q000235:genetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007621:Karyotyping; D012983:Soft Tissue Neoplasms / Q000151:congenital / Q000235:genetics*; D014314:Trisomy