title: Lack of age-related differences in temporal lobe volume of very healthy adults.
abstract: OBJECTIVE
  To evaluate age-related differences in temporal and supratemporal brain regions in carefully selected, very healthy men 19 to 92 years of age.
  
  
  METHODS
  MR quantification of brain regions used image segmentation into cerebrospinal fluid and brain matter based on nonlinear modeling of pixel intensity distributions.
  
  
  RESULTS
  There was a significant age-related decrease (approximately 1% per decade) of posterior frontal lobe volume, but not of temporal lobe volume. The mean volume of the right temporal lobe was significantly greater than the left, and this relation did not change with age.
  
  
  CONCLUSIONS
  In very healthy aging, the volume of the temporal lobes remains constant over the age range of human life.
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Md. 20892.
authors.forename: C
authors.initials: C
authors.lastname: DeCarli
authors.forename: D G
authors.initials: DG
authors.lastname: Murphy
authors.forename: J A
authors.initials: JA
authors.lastname: Gillette
authors.forename: J V
authors.initials: JV
authors.lastname: Haxby
authors.forename: D
authors.initials: D
authors.lastname: Teichberg
authors.forename: M B
authors.initials: MB
authors.lastname: Schapiro
authors.forename: B
authors.initials: B
authors.lastname: Horwitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology; D002535:Cerebral Aqueduct / Q000033:anatomy & histology; D002552:Cerebral Ventricles / Q000033:anatomy & histology; D002555:Cerebrospinal Fluid; D003071:Cognition / Q000502:physiology; D005625:Frontal Lobe / Q000033:anatomy & histology; D006801:Humans; D007360:Intelligence / Q000502:physiology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D012044:Regression Analysis; D013702:Temporal Lobe / Q000033:anatomy & histology*