title: Thermoregulatory and anesthetic-induced alterations in the differences among femoral, radial, and oscillometric blood pressures.
abstract: BACKGROUND
  A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribute to decreased hand vascular resistance, thermoregulatory vascular responses to core hyperthermia also may be important.
  
  
  METHODS
  Seven healthy volunteers were studied. Volunteers first were cooled until thermoregulatory vasoconstriction was evident. Next, each was warmed until intense sweating developed. After a cool-down period, general anesthesia was induced with propofol and N2O. Femoral artery pressure (a surrogate for central arterial pressure) and radial artery and oscillometric (brachial artery) pressures were compared during each of six defined thermoregulatory and anesthetic study conditions. To determine the effect of hand vascular resistance on blood pressure differences, measurements were compared before and after occlusion of hand blood flow. Upper-extremity blood flow was evaluated by forearm and fingertip plethysmography and laser Doppler flowmetry.
  
  
  RESULTS
  Forearm, fingertip, and cutaneous blood flow increased significantly during warming and were maximal during intense sweating. During thermoregulatory vasoconstriction, femoral, radial, and oscillometric mean blood pressures were similar. In contrast, radial artery mean pressure was 5 +/- 1 mmHg less than femoral artery mean pressure and 12 +/- 8 mmHg less than oscillometric mean pressure during intense sweating. Hand compression reduced these differences. The contour of the radial artery pressure waveform was dramatically altered by thermoregulatory and anesthetic conditions. Radial artery systolic pressure exceeded both femoral artery and oscillometric systolic pressures during vasoconstriction but was less than these during intense sweating. Hand compression reestablished the exaggerated radial artery systolic pressure during all study conditions.
  
  
  CONCLUSIONS
  Thermoregulatory and anesthetic-induced alterations in upper-extremity blood flow substantially influence the relations among femoral artery, radial artery, and oscillometric blood pressure measurements.
authors.affiliation: Department of Anesthesia, University of California, San Francisco.
authors.forename: J M
authors.initials: JM
authors.lastname: Hynson
authors.forename: D I
authors.initials: DI
authors.lastname: Sessler
authors.forename: A
authors.initials: A
authors.lastname: Moayeri
authors.forename: J A
authors.initials: JA
authors.lastname: Katz
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D001833:Body Temperature Regulation; D005263:Femoral Artery / Q000502:physiology; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D009609:Nitrous Oxide; D009991:Oscillometry; D015742:Propofol; D017534:Radial Artery / Q000502:physiology; D014661:Vasoconstriction; D014664:Vasodilation
chemical_list: D009609:Nitrous Oxide; D015742:Propofol