Biological half-life of aerosolized 99mTc-diethylenetriaminepentaacetate in various lung regions of clinically normal beagles.
The biological half-life (TB) of aerosolized 99mTc-diethylenetriaminepentaacetate was determined in 14 lung regions of 18 clinically normal Beagles. Three groups of lung regions or volumes were identified on the basis of significantly (P < 0.05) different TB. Group A (mean +/- SD TB, 82 +/- 21 minutes) included the transversely oriented cranial and caudal nonperihilar regions. Group B (mean +/- SD, 61 +/- 15 minutes) represented all sagittally oriented lung regions and the entire lung field. Group C (mean +/- SD, 49 +/- 11 minutes) included the transversely oriented cranial and caudal perihilar regions. Clearance of 99mTc-diethylenetriaminepentaacetate is considered a function of transepithelial transport into the blood, as well as bronchial transport via the mucociliary transport mechanism.
Steyn
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PF
Department of Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Gillette
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Gillette
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D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D004285:Dogs / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*
D016284:Technetium Tc 99m Pentetate