[Free radical scavenging and antifatigue activities of Saussurea involucrata polysaccharides].
The polysaccharides of Saussurea involucrata Kar et Kir was first isolated and identified by us. The polysaccharides scavenged superoxide anions by nitroblue tetraazolium colorimetric method with a median scavenging concentration of 22 micrograms.ml-1 and 95% confidence limit was 19.9-24.1 micrograms.ml-1. The polysaccharides inhibited the formation of thiobarbituric acid reaction substance in mouse liver homogenate and its IC50 was 2.3 mg/g fresh liver and 95% confidence limit was 2.05-2.55 mg/g fresh liver. By ip 25 mg.kg-1.d-1 x d in mice, the polysaccharides decreased oxygen consumption by 34.4% and ip same dosage x 6 d, the polysaccharide prolonged swimming time by 1.69-fold.
Zheng
R L
RL
Department of Biology, Lanzhou University, China.
Liu
G S
GS
Xing
G X
GX
Jia
Z J
ZJ
Du
M
M
Tan
L Q
LQ
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D005221:Fatigue / Q000517:prevention & control; D016166:Free Radical Scavengers; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D011134:Polysaccharides; D008315:Malondialdehyde