title: Salivary and serum immunoglobulins in recipients of transplanted allogeneic and autologous bone marrow.
abstract: Significantly decreased levels of all classes Ig were found in saliva and serum of 85 patients before and up to 5 years after bone marrow transplantation (BMT). Salivary levels of IgG were increased before BMT in patients that died shortly after transplantation (p = 0.04). Significantly higher secretory IgA (sIgA) levels in saliva were noted in patients with malignant disorders than in those with non-malignant diseases, both before (p = 0.007) and after BMT (p = 0.011). Recipients of autologous marrow had higher levels of salivary sIgA before BMT than recipients of allogeneic bone marrow (p = 0.020). With increased BM cell dose at transplantation, lower levels of salivary IgG and albumin were found. Patients with cytomegalovirus infections after transplantation showed increased salivary IgG levels (p = 0.029). Individuals with chronic GVHD had less salivary IgM one year after BMT (median value 3.2 mg/l, p = 0.04) than those without chronic GVHD (median value 42.6 mg/l). All Ig classes in serum were decreased directly after BMT and later normalized. Salivary levels of all Ig classes except IgD fluctuated post-BMT.
authors.affiliation: Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Norhagen
authors.forename: P E
authors.initials: PE
authors.lastname: Engström
authors.forename: B
authors.initials: B
authors.lastname: Björkstrand
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
authors.forename: C I
authors.initials: CI
authors.lastname: Smith
authors.forename: O
authors.initials: O
authors.lastname: Ringdén
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000276:immunology*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D007071:Immunoglobulin A, Secretory; D007136:Immunoglobulins