Preoptic and subthalamic connections with the caudal brainstem are important for copulation in the male rat.
Bilateral lesions of either the medial preoptic area/anterior hypothalamus (MPAH) or a subthalamic region that includes the caudal zona incerta eliminate copulation in male rats. Pathways connecting the MPAH and subthalamus with the caudal brainstem may help regulate sexual behavior. Experiment 1 showed that bilateral coronal transections of the pontine tegmentum reduce mating and that the combination of a unilateral tegmental cut with a contralateral excitotoxin lesion of either the MPAH (Experiment 2) or subthalamus (Experiment 3) virtually eliminates copulation. Asymmetric bilateral damage appears to eliminate mating through a bilateral effect common to the transection and the lesion--the destruction of connections linking the MPAH and subthalamus with the caudal brainstem. These results indicate that preoptic and subthalamic connections with the caudal brainstem are important for copulation in the male rat.
Maillard-Gutekunst
C A
CA
Department of Psychology, Emory University, Atlanta, Georgia 30322.
Edwards
D A
DA
D000818:Animals; D001931:Brain Mapping; D001933:Brain Stem / Q000502:physiology*; D003307:Copulation / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D007032:Hypothalamus, Anterior / Q000502:physiology; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011149:Pons / Q000502:physiology; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D013787:Thalamic Nuclei / Q000502:physiology*