title: Acute immune thrombocytopenic purpura: a comparative study of very high oral doses of methylprednisolone and intravenously administered immune globulin.
abstract: We compared very high doses of methylprednisolone with intravenously administered immune globulin for treatment of acute idiopathic thrombocytopenic purpura. Fifty-seven children were randomly assigned to receive the immune globulin preparation, 0.5 gm/kg per day for 5 consecutive days (n = 19), orally administered methylprednisolone, 30 mg/kg per day for 7 days (n = 19), or orally administered methylprednisolone, 50 mg/kg per day for 7 days (n = 19). There were no differences in the response of the platelet counts among the groups. We conclude that these two therapies were equally effective; choice between them may be made according to cost and therapy-related risks.
authors.affiliation: Department of Pediatric Hematology, Medical Faculty of Ondokuzmayis University, Samsun, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Albayrak
authors.forename: I
authors.initials: I
authors.lastname: Işlek
authors.forename: A G
authors.initials: AG
authors.lastname: Kalaycí
authors.forename: N
authors.initials: N
authors.lastname: Gürses
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D010976:Platelet Count / Q000187:drug effects; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone