Evidence for a second site of absorption of veralipride in the human small intestine. Use of a new drug delivery telemetric shuttle.
A new telemetric shuttle was used to coadminister veralipride (CAS 66644-81-3) and veralipride-D3 in order to test the assumption that veralipride is absorbed at two sites of the small intestine. Two different pharmacokinetic approaches were used to interpret the obtained data. According to the results, the second site of absorption of veralipride is located at a distance corresponding to 2/3 of the total length of the small intestine.
Staveris
S
S
Unité de Pharmacocinétique Clinique, Centre Hospitalier de Recherches de Purpan, France.
Houin
G
G
Dufour
A
A
Plusquellec
Y
Y
Grenier
J F
JF
Jung
L
L
Koffel
J C
JC
Saivin
S
S
D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D005772:Gastrointestinal Transit; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D051379:Mice; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D013686:Telemetry
D013469:Sulpiride; C027429:veralipride