Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine.
We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.
Suzuki
Y
Y
Pain Research Laboratory, Tsumura & Co., Ibaraki, Japan.
Oyama
T
T
Ishige
A
A
Isono
T
T
Asami
A
A
Ikeda
Y
Y
Noguchi
M
M
Omiya
Y
Y
D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008845:Microinjections; D008959:Models, Neurological; D009928:Organ Specificity; D010146:Pain / Q000503:physiopathology*; D010487:Periaqueductal Gray / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012154:Reticular Formation / Q000502:physiology
D000700:Analgesics; C019470:mesaconitine; C085283:benzoylmesaconine; D000157:Aconitine