Anencephaly with spinal dysraphism, cleft lip and palate and limb reduction defects.
We report three unrelated fetuses presenting with anencephaly, spinal dysraphism, cleft lip and palate and limb reduction defects. Review of the literature suggests that this association may be more commonly found than previously recognized and may indicate severe disturbance in early embryogenesis.
Medeira
A
A
Regional Genetics Service, St Mary's Hospital, Manchester, UK.
Dennis
N
N
Donnai
D
D
D000028:Abortion, Induced; D000757:Anencephaly / Q000150:complications / Q000196:embryology* / Q000473:pathology; D002971:Cleft Lip / Q000150:complications / Q000196:embryology* / Q000473:pathology; D002972:Cleft Palate / Q000150:complications / Q000196:embryology* / Q000473:pathology; D005260:Female; D005333:Fetus; D005532:Foot Deformities, Congenital / Q000150:complications / Q000196:embryology* / Q000473:pathology; D006228:Hand Deformities, Congenital / Q000150:complications / Q000196:embryology* / Q000473:pathology; D006801:Humans; D008297:Male; D011247:Pregnancy; D016135:Spinal Dysraphism / Q000150:complications / Q000196:embryology* / Q000473:pathology