Undifferentiated tumors: an immunohistochemical analysis on biopsies.
Immunohistochemical staining was performed on 145 biopsies with a diagnosis of undifferentiated or poorly differentiated tumor in order to classify them into lymphoid, epithelial, or mesenchymal in origin. It was possible to arrive at a histogenetic diagnosis on immunostaining in 85.5% of cases. Immunostaining confirmed the diagnosis in 32.4% and contributed to diagnosis in 53.1%. Malignant lymphoma was the most common diagnosis (35.9%), followed by carcinoma (23.4%). A panel of antibodies consisting of anti-common leucocyte antigen (LCA), anti-epithelial membrane antigen (EMA), anti-cytokeratin (CK), anti-low to intermediate molecular weight cytokeratin (CAM 5.2), anti-S-100 protein (S-100), and anti-vimentin (VM) may resolve, to a large extent, some of the common diagnostic problems.
Vege
D S
DS
Department of Pathology, Tata Memorial Hospital, Parel, Bombay.
Soman
C S
CS
Joshi
U A
UA
Ganesh
B
B
Yadav
J N
JN
D000912:Antibodies, Neoplasm / Q000032:analysis; D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis* / Q000276:immunology
D000912:Antibodies, Neoplasm