title: Therapeutic advances in immunosuppression.
abstract: Immunosuppressive therapy is appropriate for the prevention or reversal of allograft rejection, and for the treatment of autoimmune disorders and allergic disease. Recent advances in our understanding of the cellular and molecular mechanisms that regulate immune responses have paralleled elucidation of the modes of action of a variety of therapeutic immunosuppressive agents, both 'old' and new. These developments have identified potential targets for more refined and specific intervention strategies that are now being tested in the clinic.
authors.affiliation: Department of Surgery, University of Pittsburgh Medical Centre, PA 15213-2582.
authors.forename: A W
authors.initials: AW
authors.lastname: Thomson
authors.forename: J V
authors.initials: JV
authors.lastname: Forrester
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents