[State of shock during acute meprobamate poisoning. 6 cases].
The prognosis of acute meprobamate poisoning is related to shock whose haemodynamic mechanism remains obscure. We report the results of a retrospective study of six patients with meprobamate poisoning associated with shock and explored by a right heart catheterization. The age of the patients, five women and one man, ranged from 36 to 57 years. Five patients had also ingested other psychotropic drugs. A haemodynamic investigation was performed at admission to the ICU and three hours later, under treatment. Vasoplegia was the predominant feature. A myocardial dysfunction was sometimes associated, which can be explained by a moderate hypothermia. According to these results, we suggest that prior to right heart catheterization, the treatment should include inotropic and alphamimetic agents and that vascular filling should be cautious.
Landier
C
C
Service de Réanimation Médicale, CHU Bretonneau, Tours.
Lanotte
R
R
Legras
A
A
Dequin
P F
PF
Perrotin
D
D
D000328:Adult; D005260:Female; D015600:Glasgow Coma Scale; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008620:Meprobamate / Q000506:poisoning*; D008875:Middle Aged; D012189:Retrospective Studies; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000503:physiopathology; D013406:Suicide, Attempted
D008620:Meprobamate
Etat de choc lors de l'intoxication aiguë par le méprobamate. Six observations.