title: [Radioprotective effects of basic copper carboxylate complexes].
abstract: The radioprotective activity of eight selected copper (II) carboxylates--Cu (RCOO)2.nL (R = alkyl, aryl, 2-furyl and 2-thienyl; L usually represents water)--was assayed in a model of lethally gamma-irradiated (9 Gy, 0.97 Gy/min) mice. The compounds tested were applied (as solutions in saline) s.c. in three single doses of 20 mumol/kg 48.24 and 6 h before irradiation. The highest radioprotective effects were measured by survival of mice achieved after premedication of animals with copper (II) 2-thenoate monohydrate (77%), copper (II) acetylsalicylate (64%), copper (II) 2-methoxybenzoate monohydrate (62%) and copper (II) acetate monohydrate (54%). On the other hand, survival of vehicle-pretreated mice was only 10%. The observed biological properties of complexes are discussed in relation to their structures.
authors.affiliation: Katedra farmakológie a toxikológie a katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava.
authors.forename: I
authors.initials: I
authors.lastname: Gombosová
authors.forename: J
authors.initials: J
authors.lastname: Valentová
authors.forename: J
authors.initials: J
authors.lastname: Sokolík
authors.forename: M
authors.initials: M
authors.lastname: Zemlicka
authors.forename: P
authors.initials: P
authors.lastname: Svec
authors.forename: V
authors.initials: V
authors.lastname: Laginová
mesh_terms: D000818:Animals; D003300:Copper / Q000008:administration & dosage; D005720:Gamma Rays; D006168:Guinea Pigs; D051379:Mice; D008813:Mice, Inbred ICR; D009942:Organometallic Compounds / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage
chemical_list: D009942:Organometallic Compounds; D011837:Radiation-Protective Agents; D003300:Copper
vernacular_title: Radioprotektivní úcinek nĕkterých základních karboxylatomĕdnatých komplexů.