title: Treatment of polyhydramnios with indomethacin.
abstract: Polyhydramnios detected in a pregnancy should always be investigated thoroughly. We believe chromosomal abnormalities should be excluded, but that determination need not delay therapy. Indomethacin has been shown to reduce amniotic fluid volume in certain cases, but a strict monitoring schedule should be followed whenever it is administered. At our institution, we are investigating the effect on the fetus of newer, more selective prostaglandin synthetase inhibitors that should have beneficial effects similar to indomethacin, but be devoid of its unwanted side effects.
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston Texas.
authors.forename: W B
authors.initials: WB
authors.lastname: Kramer
authors.forename: I B
authors.initials: IB
authors.lastname: Van den Veyver
authors.forename: B
authors.initials: B
authors.lastname: Kirshon
mesh_terms: D000653:Amniotic Fluid / Q000187:drug effects; D000075202:Contraindications; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D005260:Female; D005323:Fetal Monitoring; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006831:Polyhydramnios / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy
chemical_list: D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin