[Mutagenic activity of copper phenoxyacetate complexes].
The mutagenic activity of phenoxyacetatocopper (II) complexes of the composition Cu(R-COO)2Ln-R = phenoxymethyl, L represents H2O (n = 3), phenazone (1), 4-nitropyridine N-oxide (1)--as well free phenoxyacetic acid and uncoordinated 4-nitropyridine N-oxide was tested against strains of Salmonella typhimurium (TA 100, TA 97 and TA 102) with or without metabolic activation. Using Ames methods in vitro, of the above-mentioned compounds only the 4-nitropyridine N-oxide complex in a concentration of 75 micrograms/dish, with 27.7% content of this neutral ligand) and this molecule ligand alone (in a concentration of 12.5 micrograms/dish) exhibited genotoxic effects. The relationship between the coordination-chemical properties and the biological effects of the compounds tested is discussed.
Blahová
M
M
Katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Sokolík
J
J
Lahitová
N
N
Murín
A
A
D003300:Copper / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens; D009942:Organometallic Compounds / Q000633:toxicity*; D010648:Phenylacetates / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D009153:Mutagens; D009942:Organometallic Compounds; D010648:Phenylacetates; D003300:Copper
Mutagénna aktivita fenoxyacetátomednatých komplexov.