title: Dramatic improvement of severe dilated cardiomyopathy in an acromegalic patient after treatment with octreotide and trans-sphenoidal surgery.
abstract: Severe congestive heart failure developed in an acromegalic patient, and was successfully treated with octreotide followed by trans-sphenoidal surgery. Clinical, hormonal echocardiographic and haemodynamic findings as well as histological heart examination before and after treatment revealed that over-production of growth hormone may induce the myocardial cell degeneration responsible for mechanical heart dysfunction. In addition, this unique example demonstrates the reversibility of myocardial damage following octreotide and trans-sphenoidal surgery, leading to significant improvement in cardiac function with minimal diastolic dysfunction and moderate interstitial fibrosis.
authors.affiliation: Department of Endocrinology, Centre Hospitalier, Universitaire de Liège, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Legrand
authors.forename: A
authors.initials: A
authors.lastname: Beckers
authors.forename: V T
authors.initials: VT
authors.lastname: Pham
authors.forename: J C
authors.initials: JC
authors.lastname: Demoulin
authors.forename: A
authors.initials: A
authors.lastname: Stevenaert
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000236:Adenoma / Q000601:surgery*; D002311:Cardiomyopathy, Dilated / Q000628:therapy*; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000601:surgery*
chemical_list: D015282:Octreotide