title: Assessment of lectin binding for prognosis in endometrial carcinoma.
abstract: The binding of Ulex europeus agglutinin-I (UEA-I) and Peanut agglutinin (PNA) was studied in 56 endometrial carcinomas. The positive rates of UEA-I and PNA were 66%. Following neuraminidase treatment, the PNA positive rate increased from 66% to 98% and most tumors stained abundantly. UEA-I staining was unaffected. Using a combined grading system based on architectural and nuclear abnormalities, the PNA positive rates of grade 1, grade 2 and grade 3 tumors were 78%, 70% and 36%, respectively. There was no correlation between UEA-I binding and the grading systems. UEA-I binding correlated significantly with the presence of myometrial invasion and vessel permeation. Metastatic endometrial carcinomas showed a high affinity of tumor cells for UEA-I. Tissues that stained with UEA-I were those from patients with the worst prognosis. PNA and UEA-I reactivities relate to the biologic activity of endometrial carcinomas. UEA-I can serve as a prognostic marker for patients with endometrial carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Sega Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ookuma
authors.forename: T
authors.initials: T
authors.lastname: Hachisuga
authors.forename: T
authors.initials: T
authors.lastname: Iwasaka
authors.forename: H
authors.initials: H
authors.lastname: Sugimori
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000401:mortality; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000378:metabolism*; D009367:Neoplasm Staging; D019887:Peanut Agglutinin; D037121:Plant Lectins; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D037102:Lectins; D019887:Peanut Agglutinin; D037121:Plant Lectins; C036850:Ulex europaeus lectins