Stability of ciprofloxacin in 5% dextrose and normal saline injections.
The stability of ciprofloxacin in 5% dextrose and normal saline i.v. admixtures have been determined using a stability-indicating high performance liquid chromatographic assay method reported in the literature. The solutions were stored in plastic bags, a procedure being used in hospitals for in or out-patient therapy. The solutions were stable for at least 3 months when stored at room or refrigerator temperatures. They remained clear throughout the study and their pH values did not change. The expiry date recommended by the manufacturer appears to be very conservative from a chemical viewpoint.
Mathew
M
M
Department of Pharmaceutics, University of Houston, TX 77030.
Das Gupta
V
V
Zerai
T
T
D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000737:chemistry / Q000378:metabolism*; D004355:Drug Stability; D004356:Drug Storage; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D012015:Reference Standards; D012462:Saline Solution, Hypertonic / Q000737:chemistry / Q000378:metabolism; D013696:Temperature
D012462:Saline Solution, Hypertonic; D002939:Ciprofloxacin; D005947:Glucose