The assessment of the HO. scavenging action of therapeutic agents.
A new method is reported for the assessment of the HO. scavenging action of therapeutic agents. It is based on the photolysis of zinc oxide and has a detection limit of 3.3%. The scavenging order of the compounds tested was penicillamine > rentiapril > ascorbic acid > cysteine > glutathione > thiomalic acid > N-acetylcysteine > myocrysin > methionine. None were as effective as DMSO. It is argued that these compounds can have an in vivo protective effect where HO. is produced from oxidant producing cells, thus limiting radical induced damage.
Russell
J
J
Department of Pure and Applied Chemistry, Strathclyde University, Glasgow.
Ness
J
J
Chopra
M
M
McMurray
J
J
Smith
W E
WE
D001391:Azo Compounds; D002374:Catalase / Q000378:metabolism; D004121:Dimethyl Sulfoxide; D016166:Free Radical Scavengers; D006863:Hydrogen-Ion Concentration; D017665:Hydroxyl Radical / Q000737:chemistry*; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry
D001391:Azo Compounds; D016166:Free Radical Scavengers; D013438:Sulfhydryl Compounds; D017665:Hydroxyl Radical; C100258:methyl orange; D002374:Catalase; D015034:Zinc Oxide; D004121:Dimethyl Sulfoxide