Peripherally administered IL-1 alpha interferes with scopolamine-induced amnesia in mice.
We studied the effects of human recombinant interleukin-1 alpha on scopolamine-induced amnesia for a passive avoidance response in the mouse. Post-training intraperitoneal administration of the cytokine (0.25 or 0.50 microgram/mouse) significantly reduced the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results indicate that peripheral interleukin-1 alpha can influence behavior and suggest the involvement of the cholinergic system in the neuromodulatory actions of this cytokine.
Bianchi
M
M
Department of Pharmacology, University of Milan, Italy.
Panerai
A E
AE
D000647:Amnesia / Q000139:chemically induced* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D006801:Humans; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D007375:Interleukin-1; D011994:Recombinant Proteins; D012601:Scopolamine