title: Low-dose irradiation and indomethacin prevent heterotopic ossification after acetabular fracture surgery.
abstract: From 1987 to 1991, we treated 53 patients with 54 fractures of the acetabulum by reconstruction through a posterior or an extended iliofemoral surgical approach. For prophylaxis against heterotopic ossification we used perioperative irradiation and indomethacin. Indomethacin was given as daily doses of 25 mg started within 24 hours of operation and continued for four weeks. Irradiation was by either 1200 cGy in three daily doses or by a single 700 cGy dose on the first postoperative day. All patients were followed for at least one year postoperatively and the severity of heterotopic ossification was recorded using the Brooker classification and correlated with hip mobility. The combination therapy proved very effective; 44 fractures showed no heterotopic ossification and ten showed Brooker class I. The functional results were good and there were no complications of this therapy. Irradiation with 1200 cGy did not appear to offer any therapeutic advantage over the 700 cGy dose.
authors.affiliation: Department of Orthopaedic Surgery, Henry Ford Hospital, Detroit, Michigan 48202-2689.
authors.forename: B R
authors.initials: BR
authors.lastname: Moed
authors.forename: E
authors.initials: E
authors.lastname: Letournel
mesh_terms: D000077:Acetabulum / Q000293:injuries* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control* / Q000532:radiotherapy*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control* / Q000532:radiotherapy*; D011859:Radiography; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
chemical_list: D007213:Indomethacin