title: Salivary PAF in acute myocardial infarction and angina: changes during hospital treatment and relationship to cardiac enzymes.
abstract: Salivary levels of platelet activating factor (PAF) were measured together with serum CPK and interleukin 2 receptor in 30 patients admitted to the coronary care unit, 9 patients with pulmonary tuberculosis, 10 with acute severe asthma and 8 normal controls. 16 of the 30 C.C.U. patients had sustained a acute myocardial infarction (M.I.) 5 had acute angina and the remaining 9 had non cardiac chest pain. Salivary PAF on admission was significantly higher in the M.I. Patients than in the normal subjects, asthmatics, tuberculosis patients and those with non cardiac chest pain (p < 0.001 in all cases) but not those with angina. After 48 hours PAF levels fell in the subjects with M.I. (p < 0.01) and no significant difference was seen between any group. PAF levels did not show any relationship with CPK levels or site of infarct in the M.I. patients. Interleukin 2 receptor was not significantly raised in the M.I. group as a whole but some individual patients showed markedly increased serum levels, but these levels did not correlate with either salivary PAF or serum CPK.
authors.affiliation: Asthma and Allergy Unit, Sully Hospital, Penarth, S. Glamorgan.
authors.forename: K P
authors.initials: KP
authors.lastname: Jones
authors.forename: S P
authors.initials: SP
authors.lastname: Reynolds
authors.forename: M
authors.initials: M
authors.lastname: Gray
authors.forename: K T
authors.initials: KT
authors.lastname: Hughes
authors.forename: S
authors.initials: S
authors.lastname: Rolf
authors.forename: B H
authors.initials: BH
authors.lastname: Davies
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D001249:Asthma / Q000097:blood / Q000201:enzymology / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000032:analysis* / Q000378:metabolism; D011863:Radioimmunoassay; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000201:enzymology / Q000378:metabolism
chemical_list: D005343:Fibrinolytic Agents; D010972:Platelet Activating Factor; D015375:Receptors, Interleukin-2; D003402:Creatine Kinase