title: Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster.
abstract: The association between quantitative genetic variation in bristle number and molecular variation at a candidate neurogenic locus, scabrous, was examined in Drosophila melanogaster. Approximately 32 percent of the genetic variation in abdominal bristle number (21 percent for sternopleural bristle number) among 47 second chromosomes from a natural population was correlated with DNA sequence polymorphisms at this locus. Several polymorphic sites associated with large phenotypic effects occurred at intermediate frequency. Quantitative genetic variation in natural populations caused by alleles that have large effects at a few loci and that segregate at intermediate frequencies conflicts with the classical infinitesimal model of the genetic basis of quantitative variation.
authors.affiliation: Center for Population Biology, University of California at Davis 95616.
authors.forename: C
authors.initials: C
authors.lastname: Lai
authors.forename: R F
authors.initials: RF
authors.lastname: Lyman
authors.forename: A D
authors.initials: AD
authors.lastname: Long
authors.forename: C H
authors.initials: CH
authors.lastname: Langley
authors.forename: T F
authors.initials: TF
authors.lastname: Mackay
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000235:genetics*; D005260:Female; D017344:Genes, Insect; D014644:Genetic Variation; D006023:Glycoproteins; D006239:Haplotypes; D015810:Linkage Disequilibrium; D008297:Male; D008969:Molecular Sequence Data; D010641:Phenotype; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping; D012679:Sense Organs / Q000033:anatomy & histology
chemical_list: D029721:Drosophila Proteins; D006023:Glycoproteins; D011506:Proteins; C066579:sca protein, Drosophila; D004247:DNA