Rearranged p53 gene with loss of normal allele in a low-grade nonrecurrent glioma.
We are studying the p53 gene profile in primary glial tumors by seeking alterations in the hybridization pattern of the tumor DNA probed with a p53 gene probe. This report documents a rearranged p53 gene with loss of the normal allele in a low-grade mixed glioma which has not recurred during 4-year follow-up. The tumor had a low 5-bromodeoxyuridine (BrdU)-labeling index and low AgNOR count. The p53 protein was not detected on immunochemical staining. To our knowledge, this is the first report of an altered p53 gene in a low-grade nonrecurrent glial tumor and highlights the presence of further checks and balances on the control of cell proliferation and other malignancy-associated phenotypes, even in an already-established tumor.
Ghosh
M
M
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi.
Dinda
A
A
Chattopadhyay
P
P
Sarkar
C
C
Bhatia
S
S
Sinha
S
S
D000483:Alleles; D001932:Brain Neoplasms / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged