title: [CD classification of lymphocytes and the function: significance of flow cytometric analysis in immunoneurological disorders].
abstract: We reviewed flow cytometric studies of lymphocyte subsets by using monoclonal antibodies in various immunoneurological disorders. In multiple sclerosis, most studies indicated decreases of suppressor T cells and suppressor-inducer T cells in both peripheral blood and cerebrospinal fluid (CSF). In HTLV-I-associated myelopathy, our studies showed an increase of CD28-negative cytotoxic T cells in the CSF, indicating the involvement of dysfunctioned cytotoxic T cells in the spinal cord lesion formation. In myasthenia gravis, the disease-specific finding is the appearance of CD4+ CD8+ (double positive) T cells in the peripheral blood, which may be associated with thymic abnormalities. These flow cytometric studies in immunoneurological disorders thus provide an insight in the pathogenesis of immunoneurological disorders.
authors.affiliation: Department of Internal Medicine, Saga Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
authors.forename: M
authors.initials: M
authors.lastname: Matsui
mesh_terms: D015703:Antigens, CD / Q000145:classification* / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology*
chemical_list: D015703:Antigens, CD