The human RAD51/RecA homologue gene is not a candidate gene for Bloom's syndrome.
The human gene HSRAD51/RecA homologue has been investigated as a possible candidate gene involved in Bloom's syndrome. No mutations were found in the cDNA isolated from three different Bloom's syndrome cell lines, thus excluding the possibility that HSRAD51 is directly involved in the syndrome. Other possible candidates are discussed.
Hellgren
D
D
Unit for Environmental Medicine, Karolinska Institute, NOVUM, Huddinge, Sweden.
Sahlén
S
S
Ljungqvist
S
S
Kenne
K
K
D001483:Base Sequence; D001816:Bloom Syndrome / Q000235:genetics*; D002460:Cell Line; D018076:DNA, Complementary / Q000032:analysis; D004268:DNA-Binding Proteins / Q000235:genetics*; D005347:Fibroblasts / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D051135:Rad51 Recombinase
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase