title: [Peridural morphine administration in restless legs status].
abstract: The restless-legs syndrome is known to occur in a familial form. The paraesthesias, which are hard to define, are sometimes compared to a painful sensation that can be alleviated only by movement. The pathomechanism of the syndrome and its aetiology are still unknown. A 67-year old patient was admitted as an emergency with most severe pain in her legs. In her family the syndrome occurred in an autosomal dominant form. A long-standing history of abuse of various analgesics was known. Initially the symptoms could not be influenced by any of the various drugs given; even epidural bupivacaine showed no effect. Dramatic relief, however, was obtained by epidural morphine. The maintenance therapy with oral morphine sulfate provided equally good results.
authors.affiliation: Institut für Anästhesiologie und operative Intensivmedizin, Zentralklinikum, Augsburg.
authors.forename: H
authors.initials: H
authors.lastname: Vahedi
authors.forename: M
authors.initials: M
authors.lastname: Küchle
authors.forename: C
authors.initials: C
authors.lastname: Trenkwalder
authors.forename: C J
authors.initials: CJ
authors.lastname: Krenz
mesh_terms: D000284:Administration, Oral; D000368:Aged; D015360:Analgesia, Epidural; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004305:Dose-Response Relationship, Drug; D004630:Emergencies; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006801:Humans; D009020:Morphine / Q000008:administration & dosage*; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000235:genetics
chemical_list: D009020:Morphine
vernacular_title: Peridurale Morphiumanwendung bei Restless-Legs-Status.