Normal oxygen tension restored in the ischemic rat liver model by PEG-hemoglobin.
Cell damage initiated during ischemia, as a result of oxygen depletion, continues during reperfusion, and recovery is dependent on the length of the ischemic period. This study investigates the effect of polyethylene glycol-modified hemoglobin (PEG-Hb) on recovery of tissue oxygen tension after induced ischemia.
Linberg
R
R
Enzon, Inc., Piscataway, NJ 08854.
Johnson
M
M
Nho
K
K
Gilbert
C
C
Shorr
R
R
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001802:Blood Substitutes / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D006454:Hemoglobins / Q000378:metabolism / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism / Q000628:therapy*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D001802:Blood Substitutes; D006454:Hemoglobins; D011092:Polyethylene Glycols; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010100:Oxygen