title: Otitis media (silent): a potential cause of childhood meningitis.
abstract: Sixteen temporal bones from 8 infants with otitis media, who died of meningitis, and 6 controls from infants with only otitis media, were studied histologically. All bones contained middle ear effusion and residual mesenchyme, but, unlike the controls, the meningitic cases showed considerable histopathological tissue changes of chronic and acute otitis media and chronic inflammatory cells in the round window membrane and within the perilymph, the modiolus, and the cochlear aqueduct, suggesting the latter as likely portals from the inner ear to the meninges. Since all tympanic membranes were intact and 3 were histologically normal, this silent route of infection warrants medical vigilance.
authors.affiliation: Otopathology Laboratory, Otitis Media Research Center, University of Minnesota.
authors.forename: D R
authors.initials: DR
authors.lastname: Djerić
authors.forename: P A
authors.initials: PA
authors.lastname: Schachern
authors.forename: M M
authors.initials: MM
authors.lastname: Paparella
authors.forename: M
authors.initials: M
authors.lastname: Jaramillo
authors.forename: S
authors.initials: S
authors.lastname: Haruna
authors.forename: M
authors.initials: M
authors.lastname: Bassioni
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D002908:Chronic Disease; D003051:Cochlea / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000209:etiology* / Q000473:pathology*; D008583:Meningitis, Haemophilus / Q000209:etiology; D010033:Otitis Media / Q000150:complications* / Q000473:pathology*; D010034:Otitis Media with Effusion / Q000150:complications / Q000473:pathology; D011008:Pneumococcal Infections / Q000209:etiology; D012189:Retrospective Studies; D013701:Temporal Bone / Q000473:pathology*