title: Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma.
abstract: Chromosome studies in a 7-week-old female infant with an intraabdominal malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +der(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appears to be a nonrandom primary cytogenetic abnormality in the congenital or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.
authors.affiliation: Division of Human Genetics, College of Medicine, University of California, Irvine.
authors.forename: R
authors.initials: R
authors.lastname: Bernstein
authors.forename: P M
authors.initials: PM
authors.lastname: Zeltzer
authors.forename: F
authors.initials: F
authors.lastname: Lin
authors.forename: P M
authors.initials: PM
authors.lastname: Carpenter
mesh_terms: D002880:Chromosomes, Human, Pair 11; D005260:Female; D005354:Fibrosarcoma / Q000151:congenital / Q000235:genetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007621:Karyotyping; D012983:Soft Tissue Neoplasms / Q000151:congenital / Q000235:genetics*; D014314:Trisomy