Chronic allograft rejection: an update.
The aetiology of chronic rejection is most likely multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalised arteriosclerosis affecting all first and second order intramural arteries. A hypothesis is presented that low-grade damage to the endothelium induces the secretion of growth factors which, in turn, are responsible for smooth muscle cell replication and their influx into intima.
Häyry
P
P
Transplantation Laboratory, Helsinki University, Finland.
Yilmaz
S
S
D000818:Animals; D002908:Chronic Disease; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D011920:Rats, Inbred WF; D014184:Transplantation, Homologous / Q000276:immunology* / Q000473:pathology