[Determination of kidney function in patients with ovarian cancer treated with chemotherapy: calculation versus measurement of creatine clearance].
In patients with ovarian cancer receiving chemotherapy we compared the creatinine clearance measured in the usual way with the calculation of the creatinine clearance according to the formulas of Jelliffe and Cockroft. Regression analysis only showed a moderate correlation, whereas the analysis of the data by ROC curves allows the use of these formulas as screening tests with acceptable values of sensitivity and false-positive rate. Therefore, in the majority of these patients, collecting urine over 24 h before starting chemotherapy is no longer necessary.
Küng
F
F
Departement für Frauenheilkunde, Universitätsspital Zürich, Schweiz.
Köchli
O R
OR
Seifert
B
B
Haller
U
U
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003404:Creatinine / Q000097:blood*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007677:Kidney Function Tests / Q000706:statistics & numerical data; D008432:Mathematical Computing; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy*; D012372:ROC Curve
D003404:Creatinine; D016190:Carboplatin; D002945:Cisplatin
Nierenfunktionsbestimmungen bei Patientinnen mit Ovarialkarzinom unter Chemotherapie: Berechnung versus Messung der Kreatinin-Clearance.