title: [Which analgesic dosage of paracetamol?].
abstract: The purpose of this study was to evaluate the dose-response of paracetamol and to assess its plasma concentration-effect relationship. According to a randomized, double-blind, and placebo controlled design healthy volunteers (n = 11) received 0.5, 1 and 2 g paracetamol (as propacetamol) intravenously (15 min). The extent of analgesic effect was measured over 8 hours by objective pain threshold (R-III) monitoring after selective transcutaneous electrical stimulation of the ipsilateral sural nerve. Maximal R-III threshold increase is at 2 hours after 0.5 g and 2.5 hours after 1 g and 2 g. The delayed peak effects, when compared to peak plasma concentrations, draw counter clockwise hysteresis. Duration of paracetamol antinociceptive effect increased concomitantly to dosage increment. Intravenous paracetamol exerts a dose-dependent central analgesia.
authors.affiliation: Division de pharmacologie clinique, Hôpital cantonal universitaire de Genève.
authors.forename: V
authors.initials: V
authors.lastname: Piguet
authors.forename: J A
authors.initials: JA
authors.lastname: Desmeules
authors.forename: L
authors.initials: L
authors.lastname: Collart
authors.forename: P
authors.initials: P
authors.lastname: Dayer
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000097:blood; D000328:Adult; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D013497:Sural Nerve / Q000187:drug effects; D004561:Transcutaneous Electric Nerve Stimulation
chemical_list: D000082:Acetaminophen
vernacular_title: Quelle posologie antalgique du paracétamol?