title: Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat.
abstract: We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a small dose of dizocilpine (0.15 mg kg-1) induced inspiratory pauses and respiratory arrest in the inspiratory phase (apneusis). Similarly, larger doses of either NBQX or dizocilpine did not induce apneusis but the addition of a small dose of the other compound provoked an apneusis. Thus, a blockade of either non-NMDA or NMDA receptors is well tolerated, but the combined blockade of both receptor types severely disrupts the respiratory function in the cat.
authors.affiliation: Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, C.N.R.S., Gif-sur-Yvette, France.
authors.forename: A S
authors.initials: AS
authors.lastname: Foutz
authors.forename: O
authors.initials: O
authors.lastname: Pierrefiche
authors.forename: M
authors.initials: M
authors.lastname: Denavit-Saubié
mesh_terms: D000818:Animals; D002415:Cats; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D011810:Quinoxalines / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012120:Respiration Disorders / Q000139:chemically induced*
chemical_list: D011810:Quinoxalines; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; D016291:Dizocilpine Maleate