title: Human papillomavirus type 16 associated with multifocal transitional cell carcinomas of the bladder in two transplanted patients.
abstract: This report describes two cases of rapidly progressive, multifocal transitional cell carcinomas of the bladder that developed in two patients after renal and cardiac transplantation, respectively. In both cases human papillomavirus (HPV) type 16 DNA was detected using the polymerase chain reaction DNA amplification method. To our knowledge, this HPV type has not been previously described in multifocal bladder transitional cell carcinoma in transplanted patients. Our findings suggest that HPV may play a major role in the development of rapidly progressive, multifocal transitional cell carcinoma in immunosuppressed patients.
authors.affiliation: Department of Pathology, Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: Noel
authors.forename: M O
authors.initials: MO
authors.lastname: Peny
authors.forename: O
authors.initials: O
authors.lastname: Mat
authors.forename: M
authors.initials: M
authors.lastname: Antoine
authors.forename: C
authors.initials: C
authors.lastname: Firket
authors.forename: O
authors.initials: O
authors.lastname: Detremmerie
authors.forename: L
authors.initials: L
authors.lastname: Thiry
authors.forename: A
authors.initials: A
authors.lastname: Verhest
authors.forename: P
authors.initials: P
authors.lastname: Vereerstraeten
mesh_terms: D001483:Base Sequence; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000821:virology*; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000821:virology*
chemical_list: D015342:DNA Probes; D004279:DNA, Viral