title: Degradation of polyetherurethane by subcutaneous implantation into rats. I. Molecular weight change and surface morphology.
abstract: Two kinds of polyetherurethane (PEU), U-3 and U-8, were coated in thin layers on an ethylene-vinylalcohol copolymer (EVAL) film 0.1 mm thick. U-3 is a nonsegmented PEU prepared from 4,4'-diisocyanatodiphenylmethane (MDI) and poly(tetramethylene oxide) of Mn = 1,000 (PTMO 1000), and U-8 is a segmented PEU prepared from MDI, PTMO 1000, and 1,4-butanediol. The coating thicknesses were 0.0068 and 0.022 mm for U-3 and U-8, respectively. These coated films were implanted subcutaneously into rats and retrieved after various weeks. The coatings on the retrieved samples were dissolved in tetrahydrofuran (THF), and the average molecular weight (MW) was determined by injecting the THF solution into a gel permeation chromatograph. In the case of U-3, MW increased after 2 weeks, then decreased over the implantation period. After 10 weeks, U-3 almost disappeared from the base film. In the case of U-8, MW reached the maximum at 4 weeks postimplantation then decreased gradually over the implantation period. The rate and degree of MW change were greater in U-3 than in U-8. Here, we argue that, in the early stage, low molecular weight PTMO/MDI oligomers leached out from the PEUs to the inflammatory exudate to increase MW, and in the later stage macrophage attachment/activation had a role in the degradation of PEUs. The surface morphologic changes observed by scanning electron microscopy are also discussed.
authors.affiliation: National Institute for Control of Pharmaceutical and Biological Products, Beijing, China.
authors.forename: T
authors.initials: T
authors.lastname: Xi
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Umemura
authors.forename: M
authors.initials: M
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kurokawa
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D002850:Chromatography, Gel; D005122:Exudates and Transudates / Q000378:metabolism; D008297:Male; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011140:Polyurethanes / Q000737:chemistry / Q000378:metabolism*; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; C115016:polyetherurethane