title: Acute myeloblastic leukemia with a pericentric inversion of chromosome 6 in a child with Down syndrome.
abstract: Cytogenetic analysis of bone marrow cells demonstrated a pericentric inversion of chromosome 6 when acute myeloblastic leukemia (AML) was diagnosed in a 15-month-old child with Down syndrome. The abnormal clone with inv(6)(p24q16) was associated with FAB-M1 AML and disappeared when a complete remission was achieved. This is a unique cytogenetic abnormality for FAB-M1 AML in a child with Down syndrome and, to our knowledge, is only the second case of a pericentric inversion of chromosome 6 reported in AML.
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Children's Hospital of Pittsburgh, Pennsylvania.
authors.forename: S
authors.initials: S
authors.lastname: Shekhter-Levin
authors.forename: J
authors.initials: J
authors.lastname: Mirro
authors.forename: L
authors.initials: L
authors.lastname: Penchansky
authors.forename: M E
authors.initials: ME
authors.lastname: Sherer
authors.forename: N
authors.initials: N
authors.lastname: Wald
authors.forename: S M
authors.initials: SM
authors.lastname: Gollin
mesh_terms: D007446:Chromosome Inversion; D002896:Chromosomes, Human, Pair 6; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008297:Male