title: Hypercalcaemia in B cell chronic lymphocytic leukaemia.
abstract: Hypercalcaemia is common in some lymphoproliferative disorders such as myeloma or T-cell leukaemia-lymphoma, but is rarely described in B cell chronic lymphocytic leukaemia (BCLL). We report the case of a patient with BCLL, hypercalcaemia and osteolytic bone lesions. Parathyroid hormone-related protein (PTHrP) mRNA was identified by Northern blot analysis of liver, spleen and lymph node tumour samples. Serum levels of tumour necrosis factor alpha (TNF alpha) were increased.
authors.affiliation: Department of Internal Medicine, Haematology and Pathology, Jean Verdier Hospital, Bondy, France.
authors.forename: O
authors.initials: O
authors.lastname: Fain
authors.forename: A
authors.initials: A
authors.lastname: el M'Selmi
authors.forename: C
authors.initials: C
authors.lastname: Dosquet
authors.forename: D
authors.initials: D
authors.lastname: Meseure
authors.forename: F
authors.initials: F
authors.lastname: Lejeune
authors.forename: J M
authors.initials: JM
authors.lastname: Garel
authors.forename: M
authors.initials: M
authors.lastname: Thomas
mesh_terms: D015152:Blotting, Northern; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D014409:Tumor Necrosis Factor-alpha