title: P-cadherin expression in human endometrium and endometriosis.
abstract: The objective of the present study was to detect the expression of P-cadherin in human endometrium and endometriosis and to compare this expression to that of E-cadherin. To this end immunohistochemistry with monoclonal antibodies specific for P-cadherin and E-cadherin was applied to endometrium and endometriotic lesions obtained in the early follicular phase of the menstrual cycle from 10 patients. P-cadherin was detected in epithelial cells in all ten endometrial samples and in all glandular structures of endometriotic lesions. The staining characteristics for P-cadherin and E-cadherin were similar. P-cadherin may play a role in the maintenance of the proliferative compartment of endometrium and could have a comparable function in endometriotic lesions.
authors.affiliation: Department of Obstetrics and Gynecology, Academisch Ziekenhuis Maastricht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Linden
authors.forename: A F
authors.initials: AF
authors.lastname: de Goeij
authors.forename: G A
authors.initials: GA
authors.lastname: Dunselman
authors.forename: J W
authors.initials: JW
authors.lastname: Arends
authors.forename: J L
authors.initials: JL
authors.lastname: Evers
mesh_terms: D015820:Cadherins / Q000032:analysis*; D004715:Endometriosis; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006801:Humans
chemical_list: D015820:Cadherins