title: 15-Deoxyspergualin controls cyclosporin- and steroid-resistant intestinal acute graft-versus-host disease after allogeneic bone marrow transplantation.
abstract: We report a case of cyclosporin- and methylprednisolone-resistant intestinal acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation which responded to a new immunosuppressant, 15-deoxyspergualin (DSG). Endoscopy showed lymphoid hyperplasia with CD3+, CD4+, CD8- lymphocyte infiltration into the submucosa of the jejunum and colon. DSG effectively suppressed this intestinal acute GVHD.
authors.affiliation: Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Higa
authors.forename: T
authors.initials: T
authors.lastname: Naohara
authors.forename: N
authors.initials: N
authors.lastname: Masauzi
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Matsuura
authors.forename: H
authors.initials: H
authors.lastname: Ohizumi
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Morii
authors.forename: Y
authors.initials: Y
authors.lastname: Kiyama
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016572:Cyclosporine / Q000627:therapeutic use; D004351:Drug Resistance; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007410:Intestinal Diseases / Q000188:drug therapy*; D008297:Male; D014184:Transplantation, Homologous
chemical_list: D000305:Adrenal Cortex Hormones; D006146:Guanidines; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C037258:gusperimus