title: Effects of a modified CMF treatment (cyclophosphamide, methotrexate and 5-fluorouracil) on hematopoietic tissues and Yoshida sarcoma in rats.
abstract: Effects of a modified CMF treatment on hematopoietic tissue and an implanted tumor were studied in rats. The modification of the treatment refers to the application of cyclophosphamide 24 h after methotrexate and 5-fluorouracil. The study was done on Wistar rats bearing Yoshida sarcoma in the ascites form. The controls were a) untreated animals bearing the tumor or b) treated conventionally with the 3 cytostatics and c) tumor-free animals under either conventional treatment or d) modified treatment. We examined survival, the appearance of metastases, and the regeneration of hematopoietic tissues. Improved survival, the absence of metastases, and improved regeneration of hematopoietic tissues was observed when modified CMF treatment was applied. These results support the importance of sequencing cytostatic protocols for basic hematological determinants and anti-tumor activity.
authors.affiliation: Institute for Nuclear Sciences, Vinca Laboratory for Radiology and Molecular Genetics, Belgrade, Yugoslavia.
authors.forename: K
authors.initials: K
authors.lastname: Savovski
authors.forename: N
authors.initials: N
authors.lastname: Pujić
authors.forename: V
authors.initials: V
authors.lastname: Vranić
authors.forename: B
authors.initials: B
authors.lastname: Dimitrijević
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008727:Methotrexate / Q000008:administration & dosage; D009368:Neoplasm Transplantation; D051381:Rats; D017208:Rats, Wistar; D012517:Sarcoma, Yoshida / Q000188:drug therapy*; D013154:Spleen / Q000187:drug effects / Q000473:pathology
chemical_list: D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate