[The interferon reaction of the leukocytes and the natural killer activity in patients with acute viral hepatitis B undergoing interferon treatment].
The interferon response of leukocytes (IRL) alpha and gamma as well as the functional activity of natural killers (NK) were studied in patients with the verified diagnosis of acute viral hepatitis B (AVH-B) treated with leukinferon (a preparation of natural interferon-alpha and cytokines) and reaferon (recombinant alpha 2 interferon). The effect of therapy with LF and RF in patients with AVH-B manifested by an increase in the functional activity of NK up to complete normalization after termination of the course of therapy. In the group of patients treated with LF as a result of therapy IRL-alpha increased by the end of the treatment and in the convalescence period. The observed activation of NK and the IF-alpha system under the effect of IF preparations in patients with AVH-B correlated with enhanced elimination of HBsAg.
Golban
T D
TD
Cheshik
S G
SG
Kuznetsov
V P
VP
Beliaev
D L
DL
Grishchenko
S V
SV
Morgunov
K M
KM
Babaiants
A A
AA
Polikushina
O E
OE
Antonenko
S M
SM
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D003289:Convalescence; D016207:Cytokines / Q000008:administration & dosage*; D004338:Drug Combinations; D006509:Hepatitis B / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000097:blood* / Q000187:drug effects; D007371:Interferon-gamma / Q000097:blood* / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D011994:Recombinant Proteins; D013997:Time Factors
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; C062252:leukinferon; D007371:Interferon-gamma
Interferonovaia reaktsiia leĭkotsitov i aktivnost' estestvennykh killerov u bol'nykh ostrym virusnym gepatitom B pri lechenii interferonom.