Surface area to volume relationships of snakes support the use of allometric scaling for calculating dosages of pharmaceuticals.
Metabolic scaling is used to estimate pharmaceutical dosages for snakes because few pharmacokinetic studies have determined optimum dosages. The question arose as to the validity of the assumption of metabolic scale among snakes because they have such a cylindrical shape. The surface area to volume relationships of a group of animals is a major portion of the metabolic scaling exponent of 0.75. An assumption inherent in scaling pharmaceutical dosages for snakes is that there is not a shape change with a size change, or that scaling of the surface area to volume has an exponent of 0.66. One hundred forty snakes, 106 Colubridae and 34 Boiidae, were weighted, their volume was determined by water displacement, and the snakes were measured. Geometric formulas were used to calculate surface area and volume of each snake. Surface area to volume relationship was nearly isometric, with a scaling exponent of 0.64, supporting the use of metabolic scaling for estimating pharmaceutical doses.
Timm
K I
KI
College of Veterinary Medicine, Oregon State University, Corvallis 97331.
Picton
J S
JS
Tylman
B
B
D000818:Animals; D001699:Biometry; D001830:Body Surface Area / Q000662:veterinary*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D012044:Regression Analysis; D012911:Snakes / Q000378:metabolism*
D004364:Pharmaceutical Preparations