Electroencephalographic response prediction of antipsychotic drug treatment in acutely ill patients and of long-term prophylactic treatment with lithium salts.
The use of the EEG as a pharmacotherapeutic response predictor is still hampered by the largely unsolved problem of extracting the relevant information from the recording in a theory-guided manner and by the likewise largely underestimated fact of pathobiological heterogeneity in diagnostically homogenous groups of patients. Instead of the usual group-statistical designs that rely solely on homogenous psychopathology, we advocate a strategy of single case studies, performed as comprehensive as possible and giving special attention to the baseline condition. It is only a certain number of such single case studies that afford an empirical data base for meaningfully applicating statistical procedures.
Ulrich
G
G
Department of Psychiatry, Free University of Berlin, Germany.
D000208:Acute Disease; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000517:prevention & control / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D011379:Prognosis
D014150:Antipsychotic Agents; D008094:Lithium