The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family.
We have found that SV40 infection of CV1 cells induces the synthesis of a 72 kDa protein that upon molecular cloning was shown to be the product of the hsc70 gene. The above gene product was found to be mainly virus inducible, in contrast to the hsp70 gene product which was mainly heat inducible. The two genes were found to be cell cycle regulated in a distinctively different manner.
Sainis
I
I
Laboratory of General Biology, Medical School, University of Ioannina, Greece.
Angelidis
C
C
Pagoulatos
G
G
Lazaridis
I
I
D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D002453:Cell Cycle / Q000502:physiology; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D000882:Haplorhini; D006358:Hot Temperature; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D012333:RNA, Messenger / Q000032:analysis; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013539:Simian virus 40 / Q000254:growth & development
D002352:Carrier Proteins; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C494371:HSPA8 protein, human; D012333:RNA, Messenger