5'-flanking region surrounding a human cytosolic phospholipase A2 gene.
The 5'-flanking region and the first four exons of a gene encoding human cytosolic phospholipase A2 (cPLA2) were isolated from a human lambda EMBL3 genomic library and sequenced. The 5'-flanking region is characterized by CA repeats, one of microsatellites. The analysis of the 5'-flanking region with transcription factor database suggests the existence of the transcription factor binding sites such as NF-kappa B, NF-IL6, AP-1, AP-2, and PEA3. These factors are well known to be induced or activated by the reagents (tumor necrosis factor alpha, interleukin-1, epidermal growth factor, and phorbol myristate acetate) reported as the inducers of a cPLA2 gene.
Morri
H
H
PRESTO, Research Development Corporation of Japan (JRDC), Osaka.
Ozaki
M
M
Watanabe
Y
Y
D001483:Base Sequence; D003600:Cytosol / Q000201:enzymology; D018076:DNA, Complementary; D005091:Exons; D006801:Humans; D008969:Molecular Sequence Data; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D011401:Promoter Regions, Genetic; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D010741:Phospholipases A; D054467:Phospholipases A2