title: Effects of sevoflurane on central nervous system electrical activity in cats.
abstract: We analyzed the effect of a new volatile anesthetic, sevoflurane (2%-5% in oxygen) on the electroencephalogram (EEG) of the neocortex, amygdala, and hippocampus, cortical somatosensory evoked potential (SEP), and brainstem reticular multiunit activity (R-MUA) in cats. Sevoflurane suppressed the background activity of the neocortex more than the amygdala and hippocampus. With increasing concentration of sevoflurane, the cortical EEG progressed from high-amplitude slow waves to a suppression-burst pattern, which was followed by an isoelectric pattern and then spikes with isoelectricity. The amplitude of the SEP was augmented and the R-MUA was suppressed by sevoflurane in a dose-related manner. Repetitive peripheral electrical stimulation induced generalized seizures at 5% sevoflurane in 2 of 13 cats. These results suggest that sevoflurane suppresses the background central nervous system electrical activities in a dose-related manner, leaving the reactive capabilities facilitated at deep anesthesia.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Osawa
authors.forename: K
authors.initials: K
authors.lastname: Shingu
authors.forename: M
authors.initials: M
authors.lastname: Murakawa
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: J
authors.initials: J
authors.lastname: Kurata
authors.forename: N
authors.initials: N
authors.lastname: Seo
authors.forename: T
authors.initials: T
authors.lastname: Murayama
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D004569:Electroencephalography / Q000187:drug effects; D004594:Electrophysiology; D004987:Ethers / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005260:Female; D008297:Male; D008738:Methyl Ethers; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane