title: Inhibition of the growth of influenza viruses in vitro by 4-guanidino-2,4-dideoxy-N-acetylneuraminic acid.
abstract: The sialidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N- acetylneuraminic acid was tested for growth inhibitory effects against a panel of avian influenza A viruses encompassing all nine neuraminidase subtypes. Growth in tissue culture of viruses from each subtype was inhibited by this compound at concentrations within a range previously found effective against human N1 and N2 viruses. This compound may prove a selective agent for the treatment (and prevention) of influenza virus infections.
authors.affiliation: AFRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.
authors.forename: G P
authors.initials: GP
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Forsyth
authors.forename: C R
authors.initials: CR
authors.lastname: Penn
authors.forename: J W
authors.initials: JW
authors.lastname: McCauley
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D006146:Guanidines; D009980:Influenza A virus / Q000187:drug effects* / Q000254:growth & development*; D011714:Pyrans; D012794:Sialic Acids / Q000494:pharmacology*; D010948:Viral Plaque Assay; D053243:Zanamivir
chemical_list: D000998:Antiviral Agents; D006146:Guanidines; D011714:Pyrans; D012794:Sialic Acids; D053243:Zanamivir