[The antitumor action of double-stranded interferon inducers (larifan, ridostin) and reaferon in an experiment].
Interferon inducers larifan and rhidostin, and reaferon were shown to exert an inhibiting antitumor effect manifested in the prolongation of the incubation period, decrease of the size of tumors, and longer survival of the animals. The maximal anti-tumor and immunomodulating effect was obtained by combined use of preimmunization with tumor cells and simultaneous administration of reaferon or interferon inducers, larifan and rhidostin. Larifan was also shown to have a greater antitumor activity than rhidostin. Larifan, however, was maximally active only in combination combination with vaccination using syngeneic cells of the virus-induced tumor. In this case levels of alpha and gamma interferons were 2-4 times higher than normally.
Barinskiĭ
I F
IF
Posevaia
T A
TA
Lavrukhina
L A
LA
Kosiakova
N P
NP
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001435:Bacteriophages / Q000235:genetics; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D007114:Immunization / Q000379:methods; D007369:Interferon Inducers / Q000008:administration & dosage*; D007370:Interferon Type I / Q000008:administration & dosage*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology / Q000628:therapy; D009930:Organic Chemicals; D012330:RNA, Double-Stranded / Q000008:administration & dosage*; D012331:RNA, Fungal / Q000008:administration & dosage*; D012367:RNA, Viral / Q000008:administration & dosage*; D011994:Recombinant Proteins; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013997:Time Factors
D000970:Antineoplastic Agents; D007369:Interferon Inducers; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009930:Organic Chemicals; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D012367:RNA, Viral; D011994:Recombinant Proteins; C076741:ridostin; C066530:larifan
Protivoopukholevoe deĭstvie dvuspiral'nykh induktorov interferona (larifana, ridostina) i reaferona v éksperimente.