title: Twelve-year follow-up study of hepatitis B immunization of Senegalese infants.
abstract: Numerous studies have documented the efficacy and safety of plasma-derived and recombinant hepatitis B vaccines. However, little is known about the long-term protection of hepatitis B vaccine, when anti-HBs declines to low or undetectable levels. This study reports results from a 9-12-year period follow up of infants immunized against hepatitis B in Senegal. At the end of the follow-up period anti-HBs were detected in 81% of children who received a booster dose at school age and in 68% of those who did not. HBsAg was detected in 19% of infants from the control group compared to only 2% of immunized infants, corresponding to a protective efficacy of 88%. The results show that long-term protection against HBsAg carriage of hepatitis B vaccination is very high and that a booster dose at school age does not significantly increase this protection.
authors.affiliation: Institut de Virologie de Tours, Faculté de Pharmacie, Tours France.
authors.forename: P
authors.initials: P
authors.lastname: Coursaget
authors.forename: D
authors.initials: D
authors.lastname: Leboulleux
authors.forename: M
authors.initials: M
authors.lastname: Soumare
authors.forename: P
authors.initials: P
authors.lastname: le Cann
authors.forename: B
authors.initials: B
authors.lastname: Yvonnet
authors.forename: J P
authors.initials: JP
authors.lastname: Chiron
authors.forename: A M
authors.initials: AM
authors.lastname: Coll-Seck
authors.forename: I
authors.initials: I
authors.lastname: Diop-Mar
mesh_terms: D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000453:epidemiology* / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000097:blood; D017325:Hepatitis B Vaccines / Q000009:adverse effects / Q000592:standards*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012675:Senegal / Q000453:epidemiology
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines