[The preventive properties and therapeutic efficacy of an antitetanus immunoglobulin for experimental intravenous administration].
The new preparation of antitetanus immunoglobulin for intravenous injection has been developed at the Kirov Research Institute of Hematology and Blood Transfusion. The technology for obtaining this preparation is based on the method of acidic fermentative hydrolysis. The preparation has high specific potency: one dose contains at least 1,500 I.U. of tetanus antitoxin. As demonstrated in the experimental study of the preparation on mice, its intravenous injection 0.5 hours after challenge completely neutralizes the action of tetanus toxin, its use 24 hours after challenge protects all animals from death, while eliminating the clinical signs of the disease in 50% of them. The intramuscular injection of the preparation has proved to be considerably less effective.
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D000704:Analysis of Variance; D000818:Animals; D003017:Clostridium tetani / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000276:immunology*; D007273:Injections, Intramuscular; D051379:Mice; D011897:Random Allocation; D013742:Tetanus / Q000517:prevention & control*; D013997:Time Factors
D016756:Immunoglobulins, Intravenous
Preventivnye svoĭstva i lechebnaia éffektivnost' protikvostolbniachnogo immunoglobulina dlia vnutrivennogo vvedeniia v éksperimente.