[Progressive supranuclear paralysis. Quantification of dopamine D2 receptors using radionuclide tomography].
Progressive supranuclear palsy (PSP) may sometimes be misdiagnosed as Parkinson's disease in its early stages, hence an early positive diagnosis of PSP based on dopamine D2 receptor density could be extremely valuable. In the present case report, the absence of dopamine D2 receptors was clearly demonstrated in the striatum using 123I-iodobenzamide (IBZM) tomoscintigraphy. This illustrates the potential use of IBZM tomoscintigraphy to identify Parkinson-like's disease presenting with decreased dopamine D2 receptor density; and hence to predict L-Dopa effectiveness. Further studies are needed to evaluate the vaue of IBZM tomoscintigraphy in the different Parkinson's like diseases.
Tranquart
F
F
INSERM U 316, CHU Bretonneau, Tours.
Le Bras
F H
FH
de Toffol
B
B
Autret
A
A
Guilloteau
D
D
Baulieu
J L
JL
D000368:Aged; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D017448:Receptors, Dopamine D2 / Q000032:analysis*; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D017448:Receptors, Dopamine D2
Paralysies supra-nucléaires progressives. Quantification des récepteurs dopaminergiques D2 par tomoscintigraphie.