[Structure of MHC molecules and binding peptides].
MHC class I associates with beta 2-microglobulin and one of a range of short peptides which bind to the groove formed by two alpha helix and beta sheet on the alpha 1 and alpha 2 domains of the class I molecules. The class I molecules present the peptides with allele-specific motif to T cells. Recent studies showed that melanoma specific CTL and minor histocompatibility specific CTL recognize peptides presented by the class I molecules. Further studies of peptides bound to the class I and class II molecules are expected to identify peptides which induce autoimmune disease.
Takiguchi
M
M
Department of Tumor Biology, University of Tokyo.
D000818:Animals; D008285:Major Histocompatibility Complex; D015394:Molecular Structure; D001613:beta 2-Microglobulin
D001613:beta 2-Microglobulin