Retinal and choroidal vessel closure using phthalocyanine photodynamic therapy.
Chloro-aluminum sulfonated phthalocyanine (CASPc) is a photoactive dye capable of generating photochemical reactions when excited with 675 nm light. We used CASPc to produce photochemical closure of retinal medullary ray vessels and choroidal vessels in normal rabbits. Irradiation prior to CASPc injection produced no photographic, angiographic, or histologic lesions in any eyes. Identical irradiation of medullary ray and choroidal vessels after CASPc injection produced complete vessel closure in all eyes. Histopathologic examination showed marked thrombosis of medullary ray and choroidal vessels, with minimal damage to contiguous tissues including the neurosensory retina. We conclude that CASPc can produce profound closure of normal retinal and choroidal vessels with minimal deleterious effect on surrounding tissues.
Kliman
G H
GH
Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Puliafito
C A
CA
Grossman
G A
GA
Gregory
W A
WA
D000535:Aluminum; D000818:Animals; D002829:Choroid / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D007211:Indoles / Q000494:pharmacology* / Q000528:radiation effects; D007834:Lasers; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000528:radiation effects; D010778:Photochemotherapy; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology* / Q000528:radiation effects; D015356:Retinal Artery Occlusion / Q000139:chemically induced* / Q000473:pathology; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000473:pathology; D012171:Retinal Vessels / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D013927:Thrombosis / Q000139:chemically induced / Q000473:pathology
D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C052736:chloroaluminum tetrasulfophthalocyanine; D000535:Aluminum