DNA damages processed by base excision repair: biological consequences.
Base damages, sugar damages, and single-strand breaks produced by free radicals are the preponderant lesions produced in DNA by ionizing radiation. These lesions have been individually introduced into substrate, template, and biologically active DNA molecules and enzymatic processing and biological consequences determined. Free radical-induced DNA lesions are processed by base excision repair and many are potentially lethal in simple viral systems. Furthermore, a number of free radical modifications of purine and pyrimidine bases are premutagenic lesions. The results of the enzymatic and biological processing of a number of the more well-studied and stable lesions are summarized.
Wallace
S S
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University of Vermont, Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, Burlington 05405.
D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair; D005609:Free Radicals; D006801:Humans; D016296:Mutagenesis
D005609:Free Radicals; D004247:DNA