title: Effectiveness of various medications on postoperative pain following root canal obturation.
abstract: This prospective study compared the effectiveness of nine medications and a placebo in controlling pain following obturation. A total of 588 patients who required root canal obturation were included. After obturation of root canals, each patient took one of the medications, salicylic acid (2 x 250 mg), acetaminophen (2 x 250 mg), ibuprofen (2 x 250 mg), ketoprofen (2 x 250 mg), acetaminophen (2 x 250 mg) plus codeine (2 x 250 mg), penicillin (2 x 250 mg), erythromycin base (2 x 250 mg), penicillin plus ibuprofen (2 x 250 mg), methylprednisolone (2 x 250 mg) plus penicillin (2 x 250 mg), or a placebo, every 6 h for 72 h. All medications were encapsulated in identical capsules. The patients registered their degree of discomfort on a visual analogue scale of 0 to 9. Statistical analysis of the data showed that the incidence of postoperative pain after obturation is lower than that following complete cleaning and shaping (5.83% versus 21.76%). In addition, there was no significant difference between the effectiveness of the various medications and placebo tablets in controlling postoperative pain following obturation.
authors.affiliation: Department of Endodontics, School of Dentistry, Loma Linda University, California.
authors.forename: M
authors.initials: M
authors.lastname: Torabinejad
authors.forename: S O
authors.initials: SO
authors.lastname: Dorn
authors.forename: P D
authors.initials: PD
authors.lastname: Eleazer
authors.forename: M
authors.initials: M
authors.lastname: Frankson
authors.forename: B
authors.initials: B
authors.lastname: Jouhari
authors.forename: R K
authors.initials: RK
authors.lastname: Mullin
authors.forename: A
authors.initials: A
authors.lastname: Soluti
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003061:Codeine / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007660:Ketoprofen / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D010406:Penicillins / Q000627:therapeutic use; D011446:Prospective Studies; D012044:Regression Analysis; D012389:Root Canal Obturation / Q000009:adverse effects*; D012459:Salicylates / Q000627:therapeutic use; D020156:Salicylic Acid
chemical_list: D010406:Penicillins; D012459:Salicylates; D000082:Acetaminophen; D004917:Erythromycin; D007660:Ketoprofen; D020156:Salicylic Acid; D003061:Codeine; D007052:Ibuprofen; D008775:Methylprednisolone