title: Acute renal failure as the cause of death in chickens following intravenous inoculation with avian influenza virus A/chicken/Alabama/7395/75 (H4N8).
abstract: One-day-old and 5-week-old commercial leghorn, specific-pathogen-free leghorn, and broiler chickens were inoculated intravenously with either avian influenza virus isolate A/chicken/Alabama/7395/75 (H4N8) (Ck/AL) or sterile diluent. Ck/AL infection resulted in a 44% mortality rate, reduced weight gains, and necrosis of proximal renal tubules and/or tubulointerstitial nephritis. The renal tubule necrosis was more severe and widespread in chickens that died than in chickens that were euthanatized. Hyperuricemia, hypercalcemia, and hyperphosphatemia were present in 5-week-old chickens at day 5 postinfection. Influenza virus isolate Ck/AL was nephropathogenic, and death was associated with acute severe renal damage and failure. Some data suggested that the pathogenicity of Ck/AL may be more severe in leghorns than broilers.
authors.affiliation: Department of Veterinary Pathobiology, Ohio State University, Columbus 43210.
authors.forename: D E
authors.initials: DE
authors.lastname: Swayne
authors.forename: M J
authors.initials: MJ
authors.lastname: Radin
authors.forename: T M
authors.initials: TM
authors.lastname: Hoepf
authors.forename: R D
authors.initials: RD
authors.lastname: Slemons
mesh_terms: D000375:Aging; D000818:Animals; D002423:Cause of Death; D002645:Chickens; D007114:Immunization / Q000662:veterinary*; D009980:Influenza A virus / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000401:mortality / Q000662:veterinary*; D007687:Kidney Tubules, Proximal / Q000473:pathology; D009336:Necrosis; D011201:Poultry Diseases; D014765:Viral Vaccines / Q000009:adverse effects*
chemical_list: D014765:Viral Vaccines