Collagen of umbilical cord arteries and its alterations in EPH-gestosis.
We decided to investigate the EPH-gestosis--connected alterations in collagen of the umbilical cord arteries. The samples of arterial walls were submitted to histological and biochemical studies. It was found that umbilical cord arteries taken from newborns of mothers with EPH-gestosis contain more than twice the amount of collagen in comparison to corresponding arteries of newborns from normal pregnancies. An increase of collagen content in these vessels in accompanied by a slight decrease of its solubility. Types I, III, IV, V and VI collagens were found both in normal umbilical cord arteries and in those of newborns delivered by mothers with EPH-gestosis but their proportional relationships were different. EPH-gestosis is accompanied by an increase of a proportional amount of type III-collagen and a decrease of type I collagen in umbilical cord arteries. It seems that these changes in the umbilical cord arteries may be responsible for the decrease of blood flow in fetus of woman with EPH-gestosis.
Bańkowski
E
E
Department of Biochemistry, Institute of Obstetrics and Gynecology, Academy of Medicine, Białystok, Poland.
Romanowicz
L
L
Jaworski
S
S
D003094:Collagen / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012995:Solubility; D014469:Umbilical Arteries / Q000378:metabolism* / Q000473:pathology
D003094:Collagen