title: A method to improve interrater reliability of visual inspection of brain MRI scans in dementia.
abstract: MR scanning is used in the clinical evaluation of patients with dementia but lacks a reliable method of visual inspection. Two neurologists conducted multiple pilot trials of alternate methods for visual inspection of MRIs, including methods that produced at least 75% interrater agreement in repeat trials, and selected a final method for rating ventricular:brain ratio (VBR), cortical atrophy, and white matter changes. Two other neurologists, new to the method, tested interrater reliability for each component of the method after a brief training session. The correlation of VBR measurement was 0.884 (p = 0.0001). The weighted kappa scores were 0.68 for overall frontal lobe atrophy, 0.38 for right temporal lobe atrophy, 0.20 for left temporal lobe atrophy, and 0.54 for parietal lobe atrophy. The weighted kappa scores were 0.77 for overall periventricular white matter hyperintensities and 0.72 for centrum semiovale hyperintensities. The proposed method may provide a rapid and reliable way to assess VBR, frontal lobe atrophy, parietal lobe atrophy, and white matter changes on brain MRIs in the evaluation of dementia, but it was less reliable for the assessment of temporal lobe atrophy.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Downey 90242.
authors.forename: J
authors.initials: J
authors.lastname: Victoroff
authors.forename: W J
authors.initials: WJ
authors.lastname: Mack
authors.forename: S T
authors.initials: ST
authors.lastname: Grafton
authors.forename: S S
authors.initials: SS
authors.lastname: Schreiber
authors.forename: H C
authors.initials: HC
authors.lastname: Chui
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D010296:Parietal Lobe / Q000473:pathology; D010865:Pilot Projects; D015203:Reproducibility of Results; D013702:Temporal Lobe / Q000473:pathology