[The use of the autocoagulation test for the detection of coagulopathies in rheumatoid arthritis].
The parameters of plasma-platelet component of hemostasis were studied by autocoagulation test in 90 patients with rheumatoid arthritis of varying activity. To specify the role of blood platelets, their counts were estimated, as was their functional activity. Plasma coagulating activity was found elevated and anticoagulating activity reduced in disease of the first and second degrees of activity, particularly so in the second degree. In patients with the third activity degree these parameters are within the normal range. The platelets augment hypercoagulation signs and reduce plasma anticoagulation potential in disease of the third degree of activity most of all. This leads to augmentation of thrombophilia signs, thus creating favorable conditions for intravascular coagulation and formation of microthrombi, which may eventually result in aggravation of rheumatoid synovitis and development of visceritis.
Amosova
E N
EN
Poroshenko
M A
MA
Karpovich
L G
LG
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis*; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
Ispol'zovanie autokoaguliatsionnogo testa dlia vyiavleniia koagulopatiĭ pri revmatoidnom artrite.