Myoglobinuric acute renal failure in a cardiac transplant patient taking lovastatin and cyclosporine.
Acute renal failure can occur in cardiac transplant patients for a variety of reasons. A case of a patient who developed acute renal failure secondarily to drug-induced rhabdomyolysis is reported. The literature regarding acute renal failure and lovastatin and other 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors is reviewed. The potential mechanisms of myoglobinuria and nephrotoxicity and the therapeutic implications are discussed.
Alejandro
D S
DS
Division of Nephrology, Stanford University School of Medicine, CA 94305-5114.
Petersen
J
J
D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects*; D016027:Heart Transplantation; D006801:Humans; D015994:Incidence; D008148:Lovastatin / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009212:Myoglobinuria / Q000209:etiology* / Q000628:therapy; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000453:epidemiology / Q000628:therapy
D016572:Cyclosporine; D008148:Lovastatin