Biological activity of amoebicin m4-A from Bacillus licheniformis M-4.
Amoebicin m4-A from Bacillus licheniformis M-4 exerts a bactericidal and bacteriolytic action on Bacillus megaterium GR10. Protein, DNA, and RNA synthesis are inhibited, and the membrane electrical potential of this bacterium is depleted by amoebicin. Synthesis of DNA and RNA by Naegleria fowleri HB-1 is also inhibited. Liposomes constructed from L-alpha-phosphatidylcholine become permeable to ions, low-molecular-weight solutes, and high-molecular-weight polymers after treatment with amoebicin.
Lebbadi
M
M
Department of Microbiology, Faculty of Sciences, University of Granada, Spain.
Gálvez
A
A
Valdivia
E
E
Martínez-Bueno
M
M
Maqueda
M
M
D000563:Amebicides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism*; D001410:Bacillus megaterium / Q000187:drug effects*; D008081:Liposomes / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D016848:Naegleria fowleri / Q000187:drug effects*; D010455:Peptides
D000563:Amebicides; D000900:Anti-Bacterial Agents; D008081:Liposomes; D010455:Peptides