title: Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.
abstract: The Long-Evans Cinnamon (LEC) rat is a mutant strain established from Long-Evans rats. LEC rats display hereditary hepatitis and spontaneous hepatocellular carcinoma (HCC). We first tried to examine effects of ethanol consumption on the development of HCC, and fed a Lieber's liquid diet containing 5% ethanol to LEC rats. However the rats died within 2 weeks because of acute alcohol intoxication. In LEC rats, the concentration of ethanol and acetaldehyde in blood was significantly higher, and liver alcohol dehydrogenase activity was slightly lower and acetaldehyde dehydrogenase activities were remarkably suppressed compared to those of Wistar rats. These results suggest that LEC rats have hereditary deficiencies of ethanol and acetaldehyde metabolizing enzymes.
authors.affiliation: Department of Internal Medicine (Section 1), Sapporo Medical University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Kohgo
authors.forename: S
authors.initials: S
authors.lastname: Katsuki
authors.forename: N
authors.initials: N
authors.lastname: Inui
authors.forename: M
authors.initials: M
authors.lastname: Ohya
authors.forename: N
authors.initials: N
authors.lastname: Takeichi
authors.forename: Y
authors.initials: Y
authors.lastname: Niitu
mesh_terms: D000079:Acetaldehyde / Q000097:blood; D000426:Alcohol Dehydrogenase / Q000235:genetics; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D000431:Ethanol / Q000493:pharmacokinetics*; D005838:Genotype; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde