title: Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA.
abstract: A cross-sectional study was conducted among prostitutes in Nairobi, Kenya, to determine the prevalence and correlates of cervical human immunodeficiency virus (HIV) DNA. Ninety-two HIV-seropositive prostitutes were evaluated during 137 clinic visits. Cervical HIV DNA was detected by polymerase chain reaction assay in 36 (39%) women at initial visits and in 40 (44%) women at any visit. There was a significant correlation between cervical HIV and microscopic evidence of cervical inflammation (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.1-24.6). Using multivariate analysis to adjust for possible confounding, the adjusted OR for the association between cervical inflammation and cervical HIV DNA was 8.7 (95% CI, 2.0-37.2). Conditions associated with cervical inflammation are associated with the detection of HIV proviral DNA. Whether such conditions lead to increased infectivity remains to be proven.
authors.affiliation: Department of Epidemiology, University of Washington, Seattle.
authors.forename: J
authors.initials: J
authors.lastname: Kreiss
authors.forename: D M
authors.initials: DM
authors.lastname: Willerford
authors.forename: M
authors.initials: M
authors.lastname: Hensel
authors.forename: W
authors.initials: W
authors.lastname: Emonyi
authors.forename: F
authors.initials: F
authors.lastname: Plummer
authors.forename: J
authors.initials: J
authors.lastname: Ndinya-Achola
authors.forename: P L
authors.initials: PL
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Hoskyn
authors.forename: S
authors.initials: S
authors.lastname: Hillier
authors.forename: N
authors.initials: N
authors.lastname: Kiviat
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006678:HIV / Q000302:isolation & purification* / Q000502:physiology; D006679:HIV Seropositivity / Q000821:virology*; D006801:Humans; D007630:Kenya; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000302:isolation & purification; D011477:Sex Work; D012725:Sexual Behavior; D002575:Uterine Cervicitis / Q000821:virology*; D017201:Virus Shedding
chemical_list: D004279:DNA, Viral