title: A single clonal abnormality of chromosome 1 found in an adenocarcinoma of the uterus.
abstract: Adenocarcinomas usually have a complex genome comprised of multiple chromosomal alterations. These neoplasms rarely express a single genomic change. We report the first case of an endometrial adenocarcinoma demonstrating a single genomic variation in chromosome 1 associated with a 2 1/2-year survival. The finding of this anomaly may be important in determining the etiology and clinical behavior of uterine malignancies.
authors.affiliation: Crozer-Chester Medical Center, Ambulatory Care Pavilion, Upland, PA 19013.
authors.forename: R B
authors.initials: RB
authors.lastname: Deger
authors.forename: J S
authors.initials: JS
authors.lastname: Noumoff
authors.forename: S A
authors.initials: SA
authors.lastname: Faruqi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002999:Clone Cells; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D014314:Trisomy