title: Aminoethylcysteine ketimine decarboxylated dimer protects submitochondrial particles from lipid peroxidation at a concentration not inhibitory of electron transport.
abstract: In contrast with other inhibitors of the NADH dehydrogenase of the respiratory chain, the decarboxylated dimer of aminoethylcysteine ketimine protects bovine heart submitochondrial particles (SMP) from the NADH-Fe(+3)-ADP-induced lipid peroxidation. This effect, measured as inhibition of malondialdehyde formation, is concentration-dependent in the range 0.02-0.2 mM. This range of concentration is not inhibitory on NADH-oxidase activity of SMP. Furthermore the dimer is able to counteract the malondialdehyde formation stimulated by the Complex I inhibitors rotenone and N-methyl-4-phenylpyridinium (MPP+).
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pecci
authors.forename: M
authors.initials: M
authors.lastname: Fontana
authors.forename: G
authors.initials: G
authors.lastname: Montefoschi
authors.forename: D
authors.initials: D
authors.lastname: Cavallini
mesh_terms: D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002417:Cattle; D004579:Electron Transport / Q000187:drug effects; D016166:Free Radical Scavengers; D005609:Free Radicals; D015227:Lipid Peroxidation; D008929:Mitochondria, Heart / Q000648:ultrastructure; D013367:Submitochondrial Particles / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000603:Amino Acids, Sulfur; D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D013481:Superoxides; C035497:thialysine ketimine