[Studies on some derivatives of crotepoxide--an antitumor constituent of Piper futokadzura].
Through reactions of deacetylation and partial deacetylation with selected opening of epoxide ring, seven derivatives of crotepoxide (futoxide), a known antitumor constituent from Piper futokudzura, were prepared. Preliminary pharmacological tests showed that individual derivative possess significant inhibitory activity at 2 x 10(-4) mol/L to the PAF-induced platelet aggregation, while crotepoxide has no effect even at fivefold of this concentration.
Chen
Z N
ZN
Department of Chemistry, Shanghai Second Medical University.
Xu
P J
PJ
D004365:Drugs, Chinese Herbal / Q000737:chemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D004852:Epoxy Compounds; D010975:Platelet Aggregation Inhibitors; C011828:futoxide