Cetaben is an exceptional type of peroxisome proliferator.
1. Cetaben in contrast to fibrates affect differently peroxisomal constituents. 2. Changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of equal doses (200 mg/kg/day) of cetaben and clofibric acid to male Wistar rats. 3. Clofibric acid treatment increased markedly the activities of FAD-glycerol-3-P dehydrogenase, beta-hydroxyacyl-CoA dehydrogenase, cytochrome-c oxidase, malic enzyme, NAD-glycerol-3-P dehydrogenase, ethoxycoumarin deethylase, p-nitroanisole demethylase and amounts of cytochrome P-450 and b5. 4. However no analogical changes were observed after cetaben treatment in the livers of experimental animals. 5. Both drugs increased the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. 6. Cetaben contrary to clofibric acid does not increase solubilization of peroxisomal enzymes. 7. Enhanced acetylcarnitine transferase and alanine-glyoxylate aminotransferase-1 activities were distributed in mitochondria as well as in peroxisomes after clofibric acid treatment, however, only peroxisomes were enriched after cetaben administration. 8. The results obtained suggest that cetaben represents an exceptional type of peroxisome proliferator, specifically affecting peroxisomes, without having a negative influence on the processes of peroxisome biogenesis.
Chandoga
J
J
Research Institute for Human Bioclimatology, Bratislava, Slovakia.
Hampl
L
L
Turecký
L
L
Rojeková
I
I
Uhliková
E
E
Hocman
G
G
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D002995:Clofibric Acid / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D008297:Male; D008830:Microbodies / Q000187:drug effects* / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D000637:Transaminases; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; D002995:Clofibric Acid; C018246:cetaben; D002332:Carnitine O-Acetyltransferase; D000637:Transaminases; D000410:Alanine Transaminase; C019635:Alanine-glyoxylate transaminase; D010129:4-Aminobenzoic Acid