title: Deliberate bee sting challenge of patients receiving maintenance venom immunotherapy at 3-month intervals.
abstract: BACKGROUND
  A large part of the cost and inconvenience associated with venom immunotherapy (VIT) is related to the need for monthly treatments. Since VIT is advocated for at least 3 to 5 years, and occasionally longer, reducing the number of venom injections may cut down significantly on both cost and inconvenience.
  
  
  OBJECTIVE
  We evaluated whether maintenance VIT given every 3 months is both safe and effective regarding reactions to treatment injections or field re-stings and lack of systemic reaction (SR) to deliberate challenge sting.
  
  
  METHODS
  The standard 1-month interval was gradually extended to 3 months in 28 patients (mean age 26 years, range 7 to 76) allergic to bee venom (BV), yellow jacket venom, or both venoms. Nineteen patients allergic to BV were deliberately challenged by a live bee sting. In 15 patients the original SR in the field was moderate; in one patient it was mild; and in three patients it was severe.
  
  
  RESULTS
  Mean duration receiving standard maintenance VIT before extending the 1-month interval was 17 months. No patient had an SR while receiving the 3-month VIT therapy. Two patients experienced four field re-stings while receiving the 3-month therapy with no reaction. After the live challenge, there was mild urticaria in a single patient; no SR developed in the rest of the patients.
  
  
  CONCLUSIONS
  For young patients allergic to BV whose initial SR is mild to moderate and who have already received 1-month VIT for longer than 17 months, the maintenance interval may safely be extended to 3 months while preserving its protective activity against re-stings.
authors.affiliation: Allergy and Clinical Immunology Unit, Meir General Hospital, Kfar Saba, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Goldberg
authors.forename: R
authors.initials: R
authors.lastname: Confino-Cohen
authors.forename: Y A
authors.initials: YA
authors.lastname: Mekori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001514:Bee Venoms / Q000008:administration & dosage* / Q000276:immunology*; D002648:Child; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001514:Bee Venoms