title: Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites.
abstract: Differentiation of somites into sclerotome, dermatome, and myotome is controlled by a complex set of inductive interactions. The ability of axial midline tissues, the notochord and floor plate, to induce sclerotome has been well documented and has led to models in which ventral somite identity is specified by signals derived from the notochord and floor plate. Herein, we provide evidence that Sonic hedgehog, a vertebrate homolog of the Drosophila segment polarity gene hedgehog, is a signal produced by the notochord and floor plate that directs ventral somite differentiation. Sonic hedgehog is expressed in ventral midline tissues at critical times during somite specification and has the ability, when ectopically expressed, to enhance the formation of sclerotome and antagonize the development of dermatome.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: R L
authors.initials: RL
authors.lastname: Johnson
authors.forename: E
authors.initials: E
authors.lastname: Laufer
authors.forename: R D
authors.initials: RD
authors.lastname: Riddle
authors.forename: C
authors.initials: C
authors.lastname: Tabin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D004627:Embryonic Induction / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D053823:Hedgehog Proteins; D008648:Mesoderm / Q000502:physiology*; D008969:Molecular Sequence Data; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D014176:Protein Biosynthesis; D011506:Proteins / Q000502:physiology*; D011994:Recombinant Proteins / Q000096:biosynthesis; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators; D014157:Transcription Factors / Q000096:biosynthesis
chemical_list: D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins; D011994:Recombinant Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C068686:Pax3 protein, mouse; C070835:PAX1 transcription factor