title: Effects of acute caffeine withdrawal on habituated male runners.
abstract: This study investigated the effects of caffeine withdrawal on six trained caffeine-habituated male runners: age 29.8 +/- 5.8 (SD) yr, height 180.4 +/- 5.4 cm, weight 77.3 +/- 6.7 kg, maximal O2 uptake 63.0 +/- 5.4 ml.kg-1.min-1, and daily caffeine intake 674 +/- 128 mg. The subjects received a loading dose (5 mg/kg body wt) of caffeine 48 h before each testing session. They were then given (using a repeated-measures double-blind design) additional doses of caffeine (5 mg/kg body wt) or a placebo 36, 24, 12, and 2 h before testing. They ran at a velocity corresponding to their lactate threshold for 60 min in a caffeine withdrawal or caffeinated condition. Caffeine withdrawal resulted in no significant differences in absolute O2 uptake, O2 uptake relative to maximal O2 uptake, respiratory exchange ratios, or free fatty acid concentrations. Glycerol concentrations were significantly attenuated in the withdrawal condition. No significant differences were revealed in calculated substrate utilization. It was concluded that caffeine withdrawal significantly affects lipolysis but not substrate utilization during prolonged running.
authors.affiliation: Department of Human Services, Curry School of Education, University of Virginia, Charlottesville 22903.
authors.forename: R K
authors.initials: RK
authors.lastname: Hetzler
authors.forename: N
authors.initials: N
authors.lastname: Warhaftig-Glynn
authors.forename: D L
authors.initials: DL
authors.lastname: Thompson
authors.forename: E
authors.initials: E
authors.lastname: Dowling
authors.forename: A
authors.initials: A
authors.lastname: Weltman
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000187:drug effects / Q000502:physiology; D002110:Caffeine / Q000009:adverse effects*; D050260:Carbohydrate Metabolism; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005223:Fats / Q000378:metabolism; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology; D012420:Running; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects / Q000502:physiology
chemical_list: D005223:Fats; D007773:Lactates; D019344:Lactic Acid; D002110:Caffeine; D005990:Glycerol