A NlaIII polymorphism within the human factor VII gene.
The polymorphism is located within exon 5 of the human coagulation factor VII gene and is silent at the amino acid level. The distribution pattern is similar in Caucasians and African Americans. This polymorphism may be useful for restriction fragment length polymorphism (RFLP) diagnosis of factor X deficiency as well as factor VII deficiency, since the factor X gene is closely linked to the factor VII locus.
Chaing
S H
SH
Department of Hospital Laboratories, University of North Carolina Hospitals, Chapel Hill 27514.
Wallmark
A
A
Berntorp
E
E
High
K A
KA
D001483:Base Sequence; D017931:DNA Primers; D015252:Deoxyribonucleases, Type II Site-Specific; D005167:Factor VII / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D017931:DNA Primers; D005167:Factor VII; C048422:endodeoxyribonuclease NlaIII; D015252:Deoxyribonucleases, Type II Site-Specific