Interference with the function of leukocyte adhesion molecules by monoclonal antibodies: a new approach to burn injury.
Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascular blood flow in burn wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocytes in the pathophysiologic response to burn injury.
Mileski
W J
WJ
Department of Surgery, Southwestern Medical Center, University of Texas, Dallas.
Rothlien
R
R
Lipsky
P
P
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001794:Blood Pressure; D002056:Burns / Q000276:immunology* / Q000503:physiopathology; D002302:Cardiac Output; D004195:Disease Models, Animal; D005260:Female; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D007957:Leukocyte Adherence Inhibition Test; D008297:Male; D008833:Microcirculation; D011817:Rabbits; D012039:Regional Blood Flow; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1