title: Cognitive brain function in non-demented patients with low-grade and high-grade carotid artery stenosis.
abstract: Atherosclerotic stenosis of the carotid arteries decreases cerebral flow volume and perfusion, and may result in brain dysfunction. We studied the relationship between the degree of carotid artery stenosis and cognitive brain function in non-demented patients. Cognitive brain function was assessed in 76 patients with carotid artery stenosis (38 patients with low-grade stenosis of 50% or less, and 38 patients with high-grade stenosis of 75% or more) by recording of cognitive P300 auditory evoked potentials and trailmaking test. Results were compared to 70 age-matched healthy subjects. The P300 peak latency was prolonged in patients with high-grade carotid artery stenosis as compared to patients with low-grade stenosis (403 vs. 371 ms, P < 0.01, vertex; 400 vs. 370 ms, P < 0.01, frontal; means). Analysis of variance revealed that the degree of carotid artery stenosis is an independent predictor of prolonged P300 peak latency (P = 0.0001). P300 amplitude (12 vs. 15 microV, vertex; 13 vs. 15 microV, frontal, NS) and trailmaking test (60 vs. 54 s; NS) tended to be worse in the high-grade stenosis group. There was no difference in cognitive brain function between patients with low-grade stenosis and age-matched healthy subjects. Confirmed on sensitive cognitive P300 measurements, we conclude that (a) cognitive brain function is impaired in non-demented patients with high-grade carotid artery stenosis but unaffected in low-grade stenosis; and (b) cognitive brain dysfunction is directly related to the degree of carotid artery stenosis.
authors.affiliation: Department of Medicine IV, University of Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Madl
authors.forename: G
authors.initials: G
authors.lastname: Grimm
authors.forename: L
authors.initials: L
authors.lastname: Kramer
authors.forename: R
authors.initials: R
authors.lastname: Koppensteiner
authors.forename: M
authors.initials: M
authors.lastname: Hirschl
authors.forename: W
authors.initials: W
authors.lastname: Yeganehfar
authors.forename: M M
authors.initials: MM
authors.lastname: Hirschl
authors.forename: A
authors.initials: A
authors.lastname: Ugurluoglu
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Ehringer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001774:Blood Chemical Analysis; D016893:Carotid Stenosis / Q000150:complications*; D003072:Cognition Disorders / Q000209:etiology*; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014145:Trail Making Test; D018615:Ultrasonography, Doppler, Color