Hemiballism-hemichorea and non-ketotic hyperglycaemia.
Three patients with hemiballism-hemichorea caused by non-ketotic hyperglycaemia are presented, two of whom had hyperosmolar non-ketotic hyperglycaemic syndrome. In two of the three patients, the hyperkinesia was the initial presenting symptom of their diabetes mellitus. The hypersensitivity of the postmenopausal dopamine receptor, decreased gamma-aminobutyric acid in the brain in non-ketotic hyperglycaemia, coexisting lacunar infarct in the basal ganglion, and pre-existing metabolic dysfunction in the basal ganglion may all have played a part in the pathogenesis of this movement disorder.
Lin
J J
JJ
Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China.
Chang
M K
MK
D000368:Aged; D001480:Basal Ganglia Diseases / Q000150:complications; D002819:Chorea / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D015161:Dementia, Multi-Infarct / Q000150:complications; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000097:blood / Q000150:complications*; D008297:Male; D008659:Metabolic Diseases / Q000150:complications; D017698:Postmenopause; D011595:Psychomotor Agitation / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000502:physiology; D013577:Syndrome; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D011954:Receptors, Dopamine; D005680:gamma-Aminobutyric Acid