4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere: synthesis and biological evaluation.
4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.
Datta
A
A
Department of Medicinal Chemistry, University of Kansas, Lawrence 66045.
Jayasinghe
L R
LR
Georg
G I
GI
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D000077143:Docetaxel; D008870:Microtubules / Q000187:drug effects; D008968:Molecular Conformation; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D043823:Taxoids
C090791:10-acetyl-4-deacetyltaxotere; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; C090790:4-deacetyltaxol; D017239:Paclitaxel