[Localization and role of cholecystokinin and its receptors in the functional organization of the basal ganglia].
In human, cholecystokinin-immunoreactive nerve fibres are abundantly distributed in the ventral striatum and in other regions of the basal ganglia interconnected with the limbic system. This suggests that this neuropeptide is involved in the initiation of movements following emotional stimuli. The demonstration of an extended cholecystokinin expression in cortico-, thalamo-, and nigrostriatal pathways using in situ hybridization indicates that this neuromodulator may have some important functions either in motor, cognitive or limbic systems. In addition, disruption of the nigrostriatal dopaminergic pathway induces the expression of cholecystokinin in the striatal neurons. This new example of functional plasticity suggests that dopamine exerts a negative tonus on cholecystokinin expression. Finally, cholecystokinin expression is increased in meso-limbic and nigrostriatal dopaminergic neurons of schizophrenic patients.
Schiffmann
S
S
D001479:Basal Ganglia / Q000737:chemistry*; D002766:Cholecystokinin / Q000235:genetics / Q000302:isolation & purification*; D004298:Dopamine / Q000494:pharmacology; D006801:Humans; D017403:In Situ Hybridization; D009434:Neural Pathways / Q000737:chemistry; D012333:RNA, Messenger / Q000302:isolation & purification; D011949:Receptors, Cholecystokinin / Q000302:isolation & purification; D012559:Schizophrenia / Q000378:metabolism
D012333:RNA, Messenger; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D004298:Dopamine
Localisation et rôles de la cholécystokinine et de ses récepteurs dans l'organisation fonctionnelle des ganglions de la base.