A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.
Chakravarty
P K
PK
Merck Research Laboratories, Rahway, New Jersey 07065.
Naylor
E M
EM
Chen
A
A
Chang
R S
RS
Chen
T B
TB
Faust
K A
KA
Lotti
V J
VJ
Kivlighn
S D
SD
Gable
R A
RA
Zingaro
G J
GJ
D000284:Administration, Oral; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004285:Dogs; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008253:Macaca mulatta; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D007093:Imidazoles; D011725:Pyridines; D000804:Angiotensin II; C090789:MK 996