title: Domestic cases of hemorrhagic fever with renal syndrome in the United States.
abstract: Although serologic studies have identified hantaviral infection in the United States, acute disease has not been recognized. This study describes 3 cases of domestically acquired hemorrhagic fever with renal syndrome (HFRS) in the United States. Infection was due to a local strain of Seoul virus (Baltimore rat virus). A review of the clinical features indicated a mild illness characterized by nausea, vomiting, renal and liver failure similar to HFRS described elsewhere for rat-borne viruses. Follow-up of 2 patients identified persistent hypertension and renal disease providing further evidence of an association between past hantaviral infection and hypertensive renal disease.
authors.affiliation: Department of Immunology and Infectious Diseases, Johns Hopkins School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
authors.forename: G E
authors.initials: GE
authors.lastname: Glass
authors.forename: A J
authors.initials: AJ
authors.lastname: Watson
authors.forename: J W
authors.initials: JW
authors.lastname: LeDuc
authors.forename: J E
authors.initials: JE
authors.lastname: Childs
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D018063:Hantaan virus / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000821:virology; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014481:United States / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral