Bactericidal activities of DU-6859a and clinafloxacin (CI-960) against staphylococci.
Time killing curves were calculated at concentrations of 2 and 8 times the MICs of DU-6859a and clinafloxacin against six isolates of Staphylococcus aureus. Both quinolones produced a decrease in the log10 CFU per milliliter of > or = 3 within 3 h at 2 and 8 times the MIC for the ciprofloxacin-susceptible isolates and at 8 times the MIC for the ciprofloxacin-resistant isolates; however, only 8 times the MIC of DU-6859a consistently prevented regrowth of all isolates after 24 h of incubation.
Forstall
G J
GJ
Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195-5140.
Knapp
C C
CC
Washington
J A
JA
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D013141:Spiro Compounds / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D013141:Spiro Compounds; C057477:clinafloxacin; C076246:sitafloxacin