title: Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice.
abstract: OBJECTIVE
  To investigate the effects of drugs known to elevate adenosine 3':5'-cyclic monophosphate (cAMP) on experimental amyloidosis.
  
  
  METHODS
  A beta 2-agonist, terbutaline, and a phosphodiesterase inhibitor, aminophylline, were administered in combination in a mouse model of amyloidosis induced by inflammatory stimulation with silver nitrate. Amyloidosis was quantitated by radioimmunoassay for splenic amyloid A (AA) protein.
  
  
  RESULTS
  At the doses selected, aminophylline/terbutaline inhibited splenic amyloid deposition more potently than did colchicine, a known inhibitor of amyloidosis.
  
  
  CONCLUSIONS
  Drugs known to elevate cAMP inhibit experimental mouse AA amyloidosis.
authors.affiliation: Rush Medical College, Chicago, Illinois.
authors.forename: S R
authors.initials: SR
authors.lastname: Brandwein
authors.forename: J D
authors.initials: JD
authors.lastname: Sipe
authors.forename: A S
authors.initials: AS
authors.lastname: Cohen
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000628:Aminophylline / Q000627:therapeutic use*; D000686:Amyloidosis / Q000517:prevention & control*; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010865:Pilot Projects; D000685:Serum Amyloid A Protein / Q000032:analysis; D013154:Spleen / Q000737:chemistry; D013726:Terbutaline / Q000627:therapeutic use*
chemical_list: D000318:Adrenergic beta-Agonists; D010726:Phosphodiesterase Inhibitors; D000685:Serum Amyloid A Protein; D000628:Aminophylline; D000242:Cyclic AMP; D013726:Terbutaline