title: Neonatal meningitis due to non-encapsulated Haemophilus influenzae in a set of twins--a case report.
abstract: A set of twins born to a 24-year-old primigravida had evidence of sepsis 24 to 60 hours after birth and were treated empirically with penicillin and gentamicin. A non-encapsulated H. influenzae biotype IV strain was isolated from the blood cultures of both and from the CSF of twin II. The isolates were beta-lactamase positive and hence showed resistance to ampicillin and therapy was changed to chloramphenicol only. Twin II recovered but Twin I developed a brain abscess in the left occipital region which resolved with extended antibiotic treatment. Although ampicillin-resistant H. influenzae have been reported in Malaysia, invasive disease by such strains are rare.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur.
authors.forename: C T
authors.initials: CT
authors.lastname: Lim
authors.forename: N
authors.initials: N
authors.lastname: Parasakthi
authors.forename: S D
authors.initials: SD
authors.lastname: Puthucheary
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy; D004200:Diseases in Twins; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006193:Haemophilus influenzae / Q000145:classification* / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008583:Meningitis, Haemophilus / Q000175:diagnosis* / Q000188:drug therapy; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents