Amplification of a c-yes-1-related oncogene in canine lymphoid leukemia.
Genomic DNAs from 4 canine spontaneous lymphoid neoplasms were examined by Southern blot hybridization using 7 kinds of oncogene probes. Analysis using a human c-yes-1 cDNA probe revealed amplification of the proto-oncogene in a DNA sample from a dog with lymphoid leukemia. Its degree was about 4- to 8-fold in comparison with a control DNA sample from a healthy dog. The genomic abnormality of canine c-yes-1-related oncogene may have a role in the tumorigenesis of this neoplasm, although the significance of the structural change in this oncogene remains unclear.
Mina
R B
RB
Department of Veterinary Surgery, Faculty of Agriculture, Miyazaki University, Japan.
Tateyama
S
S
Miyoshi
N
N
Uchida
K
K
Yamaguchi
R
R
Ohtsuka
H
H
D000818:Animals; D015139:Blotting, Southern; D018076:DNA, Complementary; D004273:DNA, Neoplasm / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000662:veterinary*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051575:Proto-Oncogene Proteins c-yes; D011519:Proto-Oncogenes; D019061:src-Family Kinases
D018076:DNA, Complementary; D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051575:Proto-Oncogene Proteins c-yes; D019061:src-Family Kinases