[Study on cutaneous physio-immuno-pathological status in tinea versicolor].
This study examined 20 cases of tinea versicolor to assess the dermato-physiological, immunological and pathological status of lesion sites as compared to 20 normal control subjects. Lesion sites showed a significant decrease in sebaceous gland secretions and water content and an increase in pH value compared to normal skin. There was no significant change in involucrin, filaggrin, or number of stratum corneum cell layers. However, lesions showed weak positive staining of IL-1 alpha. A possible mechanism for these changes is that profuse sweat gland secretions predispose to fungal growth and acid mantle destruction, with the pathogens consuming amino acids and sebum as nutrients. Slight increases in IL-1 alpha levels seen in infected areas could be due to a fungus-stimulated immune reaction in the stratum corneum.
Fang
K T
KT
Department of Dermatology, Min-Shen Municipal Hospital, Kaohsiung City, Taiwan, Republic of China.
D000328:Adult; D005260:Female; D000091344:Filaggrin Proteins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D012867:Skin / Q000473:pathology / Q000503:physiopathology*; D013545:Sweat Glands / Q000378:metabolism; D014010:Tinea Versicolor / Q000473:pathology / Q000503:physiopathology*
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007375:Interleukin-1