title: Spontaneous in vitro anti-human immunodeficiency virus type 1 antibody secretion by peripheral blood mononuclear cells is related to disease progression in zidovudine-treated adults.
abstract: As part of a continuous search for surrogate markers of therapeutic efficacy in AIDS, spontaneous in vitro production by peripheral blood mononuclear cells of antibody to human immunodeficiency virus type 1 (HIV-1) was investigated in 50 HIV-1-infected adults. It was independent of CD4+ cell counts, p24 antigenemia, serum beta 2-microglobulin concentration, and clinical status of the patients. The effect of zidovudine on this antibody secretion and the appearance of signs or symptoms of HIV-1 disease progression were evaluated in 20 patients over 24 weeks. Anti-HIV-1 antibody secretion decreased significantly (P = .002) as of the first month of zidovudine treatment only in the 13 HIV-1-infected patients without disease progression. This is earlier than the occurrence of variations in CD4+ cell count and serum beta 2-microglobulin concentration. These results suggest that in vitro antibody production could be a surrogate marker for evaluation of the in vivo antiretroviral efficacy of zidovudine, even in p24 antigen-negative patients.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 249, Institut de Biologie, Montpellier, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Conge
authors.forename: J
authors.initials: J
authors.lastname: Reynes
authors.forename: N
authors.initials: N
authors.lastname: Atoui
authors.forename: M F
authors.initials: MF
authors.lastname: Huguet
authors.forename: J
authors.initials: J
authors.lastname: Ducos
authors.forename: A
authors.initials: A
authors.lastname: Bonardet
authors.forename: A
authors.initials: A
authors.lastname: Serre
authors.forename: J P
authors.initials: JP
authors.lastname: Vendrell
mesh_terms: D000328:Adult; D015415:Biomarkers; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D015483:HIV Antibodies / Q000096:biosynthesis* / Q000097:blood; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015215:Zidovudine / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D015415:Biomarkers; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D007074:Immunoglobulin G; D001613:beta 2-Microglobulin; D015215:Zidovudine