Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Raffel
C
C
Department of Neurosurgery, Childrens Hospital Los Angeles.
Culver
K
K
Kohn
D
D
Nelson
M
M
Siegel
S
S
Gillis
F
F
Link
C J
CJ
Villablanca
J G
JG
Anderson
W F
WF
D000293:Adolescent; D000818:Animals; D001254:Astrocytoma / Q000188:drug therapy*; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D004351:Drug Resistance; D005240:Feasibility Studies; D005260:Female; D015774:Ganciclovir / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007258:Informed Consent; D007278:Injections, Spinal; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D012190:Retroviridae; D012306:Risk; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics*; D015173:Supratentorial Neoplasms / Q000188:drug therapy*; D013937:Thymidine Kinase / Q000235:genetics*; D014161:Transduction, Genetic
D013937:Thymidine Kinase; D015774:Ganciclovir