Reversed-phase solvent-gradient HPLC retention indexes of drugs.
A high-performance liquid chromatographic (HPLC) system has been developed in which ionized basic drugs and nonionized drugs elute in efficient and reproducible bands. The effects of different HPLC systems and solvent-gradient rates on the reproducibility of retention times and normalized retention data were investigated. The retention indexes of 469 drugs were determined on this system and compared with the retention indexes of drugs in common from a previously reported retention index database.
Hill
D W
DW
Microchemistry Laboratory, University of Connecticut, Storrs 06269.
Kind
A J
AJ
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D012997:Solvents
D004364:Pharmaceutical Preparations; D012997:Solvents