1,4,5-trialkyl imidazole system anti-inflammatory properties of new substituted derivatives.
In an investigation of the anti-inflammatory properties of five-membered ring nitrogen-containing heterocyclic compounds, two series of derivatives of imidazole were prepared by altering the sites of substitution and by joining aliphatic chains to the nitrogen atom in the 1 position of the imidazole ring. Some of them were more potent inhibitors of carrageenan-induced edema than indomethacin. An electron spin resonance study indicated that these compounds possess anti-radical activity.
Fatimi
J
J
Départment of Organic and Therapeutic Chemistry, Faculty of Pharmacy, Université de Limoges, France.
Lagorce
J F
JF
Duroux
J L
JL
Chabernaud
M L
ML
Buxeraud
J
J
Raby
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D002417:Cattle; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D016166:Free Radical Scavengers; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D007093:Imidazoles; D002351:Carrageenan