Parkinson's disease: a chronic, low-grade antioxidant deficiency?
The cause of Parkinson's disease (PD) is aggressively being pursued. Several hypotheses have been advanced, yet none of these completely explains the large body of evidence research has already uncovered. A new hypothesis, that PD is caused by a chronic antioxidant deficiency state, is outlined in this article. Oxidative stress, mitochondrial abnormalities, epidemiology, genetics, toxins, history of PD and diet are discussed.
Burkhardt
C R
CR
Department of Neurology, University of Colorado School of Medicine, Denver.
Weber
H K
HK
D000975:Antioxidants / Q000378:metabolism*; D004032:Diet; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism
D000975:Antioxidants