The ontogeny of tolerance to the 5-HT1A agonist 8-OH-DPAT: a study in the rat.
The 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) induces hypothermia and a flat body posture in rats. Tolerance to 8-OH-DPAT develops in adult rats with regard to these responses. The ontogeny of the ability to induce tolerance to the hypothermia and the flat body posture elicited by 8-OH-DPAT was studied. Rat pups of both sexes were given 8-OH-DPAT, 100 micrograms/kg (0.352 mumol/kg) or saline for 1, 4 or 12 days between 22 and 34 days of age. At 26 days of age no attenuation was induced by treatment during the previous 4 days. In contrast, at 34 days of age there was a clear attenuation of both responses induced by 8-OH-DPAT after an analogous 4 day treatment. The data indicate that the ability to induce tolerance to 8-OH-DPAT is not developed before 26 days of age in the rat.
Johansson-Wallsten
C E
CE
Department of Medical Pharmacology, Uppsala University, Sweden.
Meyerson
B J
BJ
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000493:pharmacokinetics / Q000494:pharmacology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D004361:Drug Tolerance; D005260:Female; D008297:Male; D011187:Posture / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000493:pharmacokinetics / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin