title: Identification and partial characterization of the c-jun oncogene in Xenopus laevis.
abstract: Sequencing analysis of a 275-nt cDNA fragment encoding the DNA-binding region at the carboxyl terminal of the Xenopus c-jun protein product shows that this region exhibits 77-79% nucleotide homology and 93% amino acid homology with the DNA-binding region of mouse and human c-jun, and contains an intact leucine zipper motif and a basic DNA-binding region. Xenopus c-jun mRNA is induced in quiescent Xenopus A6 kidney cells by 12-O-tetradecanoylphorbol-13-acetate, PDGF and cycloheximide. This 'immediate early' response suggests that Xenopus c-jun may be similar in both structure and function to that observed for its mammalian counterpart.
authors.affiliation: Division of Pathology and Toxicology, American Health Foundation, Valhalla, NY 10595.
authors.forename: P
authors.initials: P
authors.lastname: Lazarus
authors.forename: A
authors.initials: A
authors.lastname: Calcagnotto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002460:Cell Line; D016758:Genes, jun; D007668:Kidney; D016350:Leucine Zippers; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D014982:Xenopus laevis / Q000235:genetics*