Relation of components of insulin resistance syndrome to coronary disease risk.
Insulin resistance, which is a prevalent condition, has been associated with a cluster of metabolic disturbances that increase the risk of non-insulin-dependent diabetes mellitus and cardiovascular diseases. In this review article, the complexity of the etiology of insulin resistance is emphasized as it results from the interaction of genetic and environmental factors. Potential cellular defects underlying insulin resistance are discussed as well as the relation of impaired insulin action to dyslipidaemia and coronary heart disease.
Després
J P
JP
Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Quebec, Canada.
Marette
A
A
D000273:Adipose Tissue; D003327:Coronary Disease / Q000150:complications* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004032:Diet; D015444:Exercise; D020022:Genetic Predisposition to Disease; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics; D012307:Risk Factors
D007328:Insulin