title: Effects of RTC-silicone maxillofacial prosthetic elastomers on cell cultures.
abstract: The use of a wide variety of materials in the construction of maxillofacial prostheses makes biocompatibility testing a necessity. However, the dental literature contains few reports of biocompatibility testing of maxillofacial prosthetic materials. The cytotoxic profiles of five room-temperature cross-linking (RTC)-silicone elastomers were investigated by means of two in vitro cell culture techniques. Mouse fibroblast cells (L929) were used, and the results indicated that RTC-silicone elastomers adversely affected cells in culture and that storage of samples for 1 week in saline solution did not alter this effect. Clinical follow-up of patients wearing prostheses made of these silicone materials is warranted to evaluate host reactions in long-term contact with human mucous membrane and skin tissue.
authors.affiliation: Department of Prosthodontics, School of Dentistry, University of Athens, Greece.
authors.forename: G L
authors.initials: GL
authors.lastname: Polyzois
authors.forename: A
authors.initials: A
authors.lastname: Hensten-Pettersen
authors.forename: A
authors.initials: A
authors.lastname: Kullman
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D008422:Materials Testing; D008447:Maxillofacial Prosthesis; D051379:Mice; D012826:Silicone Elastomers / Q000633:toxicity*
chemical_list: D001672:Biocompatible Materials; D012826:Silicone Elastomers