title: [Effects of general anesthesia on the regulation of hydrogen peroxide metabolism in erythrocytes].
abstract: Changes in superoxide dismutase (SOD), catalase (C), and peroxidase (P) blood activity, as well as the activity of glucose-6-phosphate dehydrogenase (G-6-PDH), isocitrate dehydrogenase (ICDH), malate dehydrogenase (MDH), and peroxide resistance of erythrocytes (PRE) have been studied in 45 gastroenterologic patients under different types of general anesthesia. A significant increase in G-6-PDH, SOD, K, P activity and an increase in ICDH and MDH activity, as well as a drop in PRE which tends to return to baseline postoperatively have been established during general anesthesia. SOD expressed the greatest intergroup differences. A fragment of mechanism of energy transfer in the erythrocyte aimed at hemoglobin oxygenation and tissue hypoxia compensation has been suggested.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Malyshev
authors.forename: V A
authors.initials: VA
authors.lastname: Skliar
authors.forename: E F
authors.initials: EF
authors.lastname: Kochergin
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D002374:Catalase / Q000097:blood; D013505:Digestive System Surgical Procedures; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood* / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008291:Malate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000097:blood; D011184:Postoperative Period; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
chemical_list: D006861:Hydrogen Peroxide; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010544:Peroxidases; D002374:Catalase; D013482:Superoxide Dismutase
vernacular_title: Vliianie obshcheĭ anestezii na reguliatsiiu metabolizma perekisi vodoroda v éritrotsite.