title: Successful treatment of sinusitis caused by Cunninghamella bertholletiae.
abstract: Seventeen cases of infections due to Cunninghamella species have been reported worldwide in humans, and there have been only three survivors. We report a case of paranasal sinusitis due to Cunninghamella bertholletiae in an elderly patient who had diabetes mellitus and myelodysplasia. After receiving 7 weeks of therapy with deoxycholate amphotericin B (44 mg/kg or a total of 3 g) and rifampin, the patient was cured and did not have to undergo radical surgery.
authors.affiliation: Department of Microbiology, Hope Hospital, Manchester, United Kingdom.
authors.forename: T T
authors.initials: TT
authors.lastname: Ng
authors.forename: C K
authors.initials: CK
authors.lastname: Campbell
authors.forename: M
authors.initials: M
authors.lastname: Rothera
authors.forename: J B
authors.initials: JB
authors.lastname: Houghton
authors.forename: D
authors.initials: D
authors.lastname: Hughes
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004359:Drug Therapy, Combination; D015521:Ethmoid Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D009090:Mucorales / Q000302:isolation & purification; D009091:Mucormycosis / Q000150:complications / Q000188:drug therapy*; D009190:Myelodysplastic Syndromes / Q000150:complications; D010256:Paranasal Sinuses / Q000382:microbiology; D012293:Rifampin / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D000666:Amphotericin B; D012293:Rifampin