[Studies on the antitumor effect of Clerodendrum bungei Steud or C. foetidum Bge].
Clerodendrum B(I) at dosage of 100g/kg ip or sc for 7 days was shown to have antitumor effect on hepatic carcinoma and sarcoma 180 in mice. In the mean time, 100g/kg sc of (I) interrupted 3H-TdR incorporation into DNA of sarcoma 180 cells in mice, 100, 10g/kg sc of (I) could suppress the phagocytic activity of the peritoneal macrophage against the CRBC (chicken red blood cells) in mice, 100g/kg sc of (I) also made the production of serum hemolysin less than one half of that of the control in mice immunized with SRBC. Clerodendrum C at 100g/kg could inhibit the growth of hepatic carcinoma in mice.
Shi
X F
XF
Sichuan Institute of Chinese Materia Medica, Chongqing.
Du
D J
DJ
Xie
D C
DC
Ran
C Q
CQ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010587:Phagocytosis / Q000187:drug effects; D012510:Sarcoma 180 / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal