Genetics of osteoporosis.
Identification of the major contribution of genetic factors in determination of peak bone mass at skeletal maturity and possibly on subsequent age-related bone loss has led to efforts to identify possible mechanisms. Recent evidence suggests one mechanism relates to genetic effects on bone turnover mediated via the vitamin D system. This field of research has potential for reducing osteoporotic fracture risk by allowing interventions at different stages in life to reduce this increasing problem of ageing societies.
Sambrook
P N
PN
Garvan Institute of Medical Research, Department of Endocrinology, St Vincent's Hospital, Sydney, Australia.
Kelly
P J
PJ
Morrison
N A
NA
Eisman
J A
JA
D000375:Aging / Q000502:physiology; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D010024:Osteoporosis / Q000150:complications / Q000235:genetics*; D018433:Twin Studies as Topic