Myopathy with ragged red fibres following renal transplantation: possible role of cyclosporin-induced hypomagnesaemia.
A 65-year-old man developed a painless proximal myopathy 7 years after commencing cyclosporin therapy following a successful cadaveric renal transplant. Muscle histology showed ragged red fibres and biochemical studies suggested mitochondrial dysfunction. The possible pathogenesis of this mitochondrial myopathy, particularly its relationship to cyclosporin-induced hypomagnesaemia, is discussed.
Larner
A J
AJ
Midland Centre for Neurosurgery and Neurology, Warley, West Midlands, UK.
Sturman
S G
SG
Hawkins
J B
JB
Anderson
M
M
D000368:Aged; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D008275:Magnesium Deficiency / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008931:Mitochondria, Muscle / Q000502:physiology / Q000648:ultrastructure; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000209:etiology / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology*
D016572:Cyclosporine