title: Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice.
abstract: s.c. and abdominal tumors from interspecific hybrid, transgenic mice containing the SV40 early region linked to a renin enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions involved in tumorigenesis. A very high frequency of loss of heterozygosity/partial loss of heterozygosity or allelic imbalance involving the distal regions of chromosome 8 was observed in the s.c. tumors (76%) with frequent amplification (3-6 times) of the corresponding proximal regions including Junb, suggesting that chromosome 8 breakage and amplification promotes tumorigenesis in these mice.
authors.affiliation: Roswell Park Cancer Institute, Department of Molecular and Cellular Biology, Buffalo, New York 14263.
authors.forename: W A
authors.initials: WA
authors.lastname: Held
authors.forename: J G
authors.initials: JG
authors.lastname: O'Brien
authors.forename: K
authors.initials: K
authors.lastname: Kerns
authors.forename: J F
authors.initials: JF
authors.lastname: Gallagher
authors.forename: C D
authors.initials: CD
authors.lastname: Sigmund
authors.forename: K W
authors.initials: KW
authors.lastname: Gross
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D002872:Chromosome Deletion; D005260:Female; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000235:genetics*
chemical_list: D000952:Antigens, Polyomavirus Transforming; D012083:Renin