Ferritin stimulation of a monokine inhibitor of lipopolysaccharide-augmented myelopoiesis is ferroxidase dependent.
Ferritin inhibition of myelopoiesis has been associated with intrinsic ferroxidase activity of heavy-chain ferritin and with production of a monokine inhibitor of lipopolysaccharide (LPS)-augmented monocytopoiesis. We report here that intrinsic ferroxidase activity of heavy-chain ferritin is required for stimulated production of the monokine inhibitor of LPS-augmented monocytopoiesis.
Kreisberg
R
R
Department of Microbiology, University of Tennessee, Knoxville 37996-0845.
Broxmeyer
H E
HE
Moore
R N
RN
D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D002570:Ceruloplasmin / Q000378:metabolism*; D005293:Ferritins / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D009000:Monocytes / Q000502:physiology; D015846:Monokines / Q000037:antagonists & inhibitors; D009842:Oligopeptides / Q000494:pharmacology
D008070:Lipopolysaccharides; D015846:Monokines; D009842:Oligopeptides; D005293:Ferritins; D002570:Ceruloplasmin