title: [The optimization of Capoten treatment by taking into account its chronosensitivity in hypertension patients].
abstract: The trial was made of Capoten used according to the conventional scheme (14 patients) against the drug regimen chronosensitivity-adjusted (15 patients). All the patients had essential hypertension stage II. When used at the hours of the greatest sensitivity, Capoten proved more effective this permitting lower single, daily and course doses administration, hypotensive effect occurred in shorter period of time. The effect was produced via a marked fall in peripheral vascular resistance.
authors.forename: R M
authors.initials: RM
authors.lastname: Zaslavskaia
authors.forename: K Zh
authors.initials: KZh
authors.lastname: Akhmetov
authors.forename: F
authors.initials: F
authors.lastname: Hulberg
authors.forename: M M
authors.initials: MM
authors.lastname: Teiblum
mesh_terms: D000328:Adult; D000368:Aged; D002216:Captopril / Q000008:administration & dosage* / Q000494:pharmacology; D002909:Chronobiology Phenomena / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002216:Captopril
vernacular_title: Optimizatsiia lecheniia kapotenom s uchetom khronochuvstvitel'nosti k nemu bol'nykh gipertonicheskoĭ bolezn'iu.