title: Carbogen breathing in patients with glioblastoma multiforme submitted to radiotherapy. Assessment of gas exchange parameters.
abstract: It has been reported that carbogen breathing yields a remarkable increase of radiosensitivity in murine tumour models. Hence, application of carbogen might be promising in radiotherapy of human tumours. We describe a method to increase arterial oxygenation and to ensure stability of O2 and CO2 during carbogen breathing in patients with malignant disease. We measured in 6 patients with histologically proven intracranial glioblastoma multiforme arterial blood gases, inspired and expired gas concentrations and vital signs either baseline and during carbogen breathing. The highest values of arterial oxygenation were achieved after 10 min of carbogen breathing and they remained stable up to 15 min. In none of our patients was N2 wash-out from the lungs completed in 15 min of carbogen breathing. In conclusion, carbogen breathing increased arterial oxygenation in patients with intracranial malignant diseases. The system used is reliable and of practical use. Monitoring of expired gas concentrations is highly recommended.
authors.affiliation: Department of Radiology, University of Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Fatigante
authors.forename: F
authors.initials: F
authors.lastname: Cartei
authors.forename: F
authors.initials: F
authors.lastname: Ducci
authors.forename: C
authors.initials: C
authors.lastname: Marini
authors.forename: R
authors.initials: R
authors.lastname: Prediletto
authors.forename: P
authors.initials: P
authors.lastname: Caciagli
authors.forename: M
authors.initials: M
authors.lastname: Laddaga
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D001932:Brain Neoplasms / Q000097:blood / Q000532:radiotherapy*; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D005909:Glioblastoma / Q000097:blood / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011659:Pulmonary Gas Exchange; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen