title: [Value of treatment of low-grade glioma still controversial].
abstract: There is debate in the literature on the treatment of low-grade glioma, especially regarding the role of radiotherapy. Several retrospective analyses have demonstrated longer survival and delayed tumour recurrence in patients treated with radiotherapy. However, radiotherapy may bring about adverse events, especially in long-term survivors. In four patients, a women of 54 and three men of 51, 31 and 16 years old, a low-grade glioma was diagnosed. In three, expectative therapy, combined with antiepileptic drugs, or with radiotherapy and partial tumour resection (n = 1) led to a period of many years without symptoms. In the fourth, total tumour resection followed by radiotherapy did not prevent recurrence of the tumour and death of the patient.
authors.affiliation: Academisch Ziekenhuis, vakgroep Neurologie, Maastricht.
authors.forename: A
authors.initials: A
authors.lastname: Twijnstra
authors.forename: M J
authors.initials: MJ
authors.lastname: Taphoorn
authors.forename: J
authors.initials: J
authors.lastname: Troost
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001254:Astrocytoma / Q000175:diagnosis / Q000628:therapy*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
chemical_list: D000927:Anticonvulsants
vernacular_title: Nut van behandeling van laaggradig glioom nog omstreden.