[Free radicals of oxygen and superoxide dismutase. Biological and medical aspects].
Oxygen free radicals (OFR) are very reactive and unstable metabolites capable of altering important biomolecules including proteins, lipids and nucleic acids. OFR are regulated by enzymes such as superoxide dismutases (SOD), catalase, glutation peroxidase and by molecules such as vitamins E, A, C, and K, selenio, cystein and other compounds. Increased OFR levels due to an overproduction of these metabolites or to a failure in the control system, induce cellular and tissue injuries that could lead to diseases such as atherosclerosis, arthritis, fibrosis, lung and heart injuries, neurological disorders and cancer. In this article we consider the use of SOD as therapeutic agents both in human and experimental models. We also refer to the administration of SOD as a protective factor against secondary injuries during radiotherapy and to the determination of SOD as a tumor marker.
Monte
M
M
Instituto de Oncología Angel H. Roffo, Universidad de Buenos Aires, Argentina.
Sacerdote de Lustig
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E
D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D005609:Free Radicals; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase
Radicales libres de oxígeno y superóxido dismutasas. Aspectos biológicos y médicos.