The expression of phospholipase A2 and lipocortins (annexins) I, II and V in human fetal membranes and placenta in association with labour.
We have studied the expression of the cellular, type two phospholipase A2 and lipocortins (annexins) I, II and V in human amnion, chorion-decidua and placenta using northern analysis. We found no difference in the expression of phospholipase A2 or lipocortin V in tissues obtained before or after labour. Lipocortin I expression was found to decrease in amnion and placenta but increase in chorion decidua with the onset of labour, while expression of lipocortin II increased only in amnion. These results support the hypothesis that the increased phospholipase A2 activity in the fetal membranes and placenta which is associated with labour is not due to increased phospholipase A2 gene expression, but that post translational control of phospholipase A2 activity may be mediated through changes in lipocortin I expression.
Bennett
P
P
Action Research Laboratory for the Molecular Biology of Fetal Development, Royal Post Graduate Medical School, London, England.
Slater
D
D
Berger
L
L
Moor
G
G
D017305:Annexin A1 / Q000096:biosynthesis / Q000235:genetics; D017306:Annexin A2 / Q000096:biosynthesis / Q000235:genetics; D017304:Annexin A5 / Q000096:biosynthesis / Q000235:genetics; D017302:Annexins / Q000096:biosynthesis* / Q000235:genetics; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000502:physiology*; D010741:Phospholipases A / Q000096:biosynthesis* / Q000235:genetics; D054467:Phospholipases A2; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis
D017305:Annexin A1; D017306:Annexin A2; D017304:Annexin A5; D017302:Annexins; D012333:RNA, Messenger; D010741:Phospholipases A; D054467:Phospholipases A2