title: [Influence of pancreatic insulin reserve on the metabolic control of type I and II diabetes mellitus].
abstract: We have studied 22 diabetic patients, 14 type I and 8 type II, in order to determine if there is a correlation between metabolic control and pancreatic reserve of insulin. All the patients were treated with optimum doses of bolus/basal insulin. They underwent a peptide C test (at baseline and after 3 stimulus with glucagon) and every month, during 3 months, HbA1c and fructosamine were measured, with monthly self control of glycemia. Both HbA1c and fructosamine showed a statistically significant improvement during the study. In all the cases, there was a negative correlation between metabolic control and pancreatic reserve, with statistical significance for type I, especially regarding the response of peptide C to the administration of glucagon. We conclude that the preservation of a good endogenous secretion of insulin benefits the metabolic control of diabetes.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Universitario de San Carlos, Madrid.
authors.forename: J R
authors.initials: JR
authors.lastname: Calle Fernández
authors.forename: M A
authors.initials: MA
authors.lastname: Rubio Herrera
authors.forename: A L
authors.initials: AL
authors.lastname: Calle Pascual
authors.forename: E
authors.initials: E
authors.lastname: Bordíu Obanza
authors.forename: J P
authors.initials: JP
authors.lastname: Marañes Pallardo
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*
chemical_list: D007328:Insulin
vernacular_title: Influencia de la reserva pancreática de insulina sobre el control metabólico de las diabetes tipos I y II.