[Acetylation of histones in vitro causes chromatin decompactization].
It has been discovered that chemical acetylation of chromatin in vitro by acetyladenylate leads to decrease in the mobility of nucleosomal fiber fragments in agarose gel. Acetylation of HI-depleted chromatin does not produce this effect. Based on these results together with other available data, it is possible to conclude that acetylation causes decompactization of the chromatin fiber. A possible molecular mechanism of in vivo fiber decondensation and interaction of different chromatin compactization levels is discussed.
Kraevskiĭ
V A
VA
Panin
V M
VM
Razin
S V
SV
D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000737:chemistry*; D006657:Histones / Q000737:chemistry*; D008099:Liver / Q000737:chemistry; D051381:Rats
D002843:Chromatin; D006657:Histones
Atsetilirovanie gistonov in vitro vyzyvaet dekompaktizatsiiu khromatina.