title: HIV-2 EHO isolate has a divergent envelope gene and induces single cell killing by apoptosis.
abstract: The human immunodeficiency virus type 2 (HIV-2)-related isolate, referred to as HIV-2 EHO, has been isolated from an Ivory Coast patient with acquired immunodeficiency syndrome (AIDS). Infection of CD4 expressing cells with this highly infectious virus mediates a cytopathic effect characterized by single-cell killing as a consequence of apoptosis. Nucleotide sequence analysis of the HIV-2 EHO genome revealed a significant degree of divergence of its envelope gene from that of other known HIV-2 strains. This divergence for the deduced amino acid sequence corresponding to the extracellular envelope glycoprotein was 26 to 30%. These unique genetic and biological properties suggest that the HIV-2 EHO isolate is a distinct prototype in the HIV-2 family.
authors.affiliation: Department of AIDS and Retroviruses, UA CNRS 1157, Institut Pasteur, Paris, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Rey-Cuille
authors.forename: J
authors.initials: J
authors.lastname: Galabru
authors.forename: A
authors.initials: A
authors.lastname: Laurent-Crawford
authors.forename: B
authors.initials: B
authors.lastname: Krust
authors.forename: L
authors.initials: L
authors.lastname: Montagnier
authors.forename: A G
authors.initials: AG
authors.lastname: Hovanessian
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000595:Amino Acid Sequence; D017209:Apoptosis; D002478:Cells, Cultured; D015752:Genes, env; D014644:Genetic Variation; D015726:Giant Cells / Q000382:microbiology; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015498:HIV-2 / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D015699:HIV Envelope Protein gp120