Interleukin-1 beta plasma secretion during diurnal spontaneous and induced sleeping in healthy volunteers.
We previously reported nocturnal plasma IL-1 beta (beta) increases during sleep in absence of stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis. In this paper we evaluate the presence of plasma IL-1 beta secretion in nine healthy volunteers (mean age 31.2 +/- 4.2) during post-prandial naps, after the administration of zolpidem, a benzodiazepine receptorial agonist. Although a significant increase in IL-1 beta plasma levels during spontaneous sleep was present in only four subjects when compared to those obtained during wake and induced-sleep, spontaneous sleep IL-1 beta mean plasma levels appeared slightly higher than both wake and induced-sleep values. Moreover, a negative correlation was present between IL-1 beta and cortisol (F) values obtained during the early afternoon (r = 7; p < 0.05). Our findings are consistent with a possible association of IL-1 beta secretion to physiologic sleep also during daytime spontaneous naps, with the presence of F influence on this phenomenon, and with the lack of IL-1 beta association to daytime naps after sleep-inducer pharmacological agents.
Covelli
V
V
Chair of Neurology I, Medical School University Federico II, Naples, Italy.
D'Andrea
L
L
Savastano
S
S
Valentino
R
R
Tommaselli
A P
AP
Selleri
A
A
Massari
F
F
Lombardi
G
G
D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D011725:Pyridines / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology*; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D007375:Interleukin-1; D011725:Pyridines; D000077334:Zolpidem