Nucleolar accumulation of Semliki Forest virus nucleocapsid C protein: influence of metabolic status, cytoskeleton and receptors.
The nucleolar accumulation of Semliki Forest Virus (SFV) C protein was examined as a function of intact microtubules, intact microfilaments and accessible intermediate filaments. The cytoskeletal components do not seem to play a role in directing C protein to the nucleolus but nucleolar accumulation is energy-dependent and saturable. This suggests the involvement of some receptor- (or chaperon-) interaction.
Jakob
R
R
Institute for Applied Cell Culture, Munich, Germany.
D000818:Animals; D015153:Blotting, Western; D002213:Capsid / Q000378:metabolism*; D002466:Cell Nucleolus / Q000378:metabolism* / Q000382:microbiology; D003599:Cytoskeleton / Q000378:metabolism* / Q000382:microbiology; D011991:Receptors, Virus / Q000378:metabolism*; D012672:Semliki forest virus / Q000378:metabolism* / Q000648:ultrastructure; D014709:Vero Cells; D014758:Viral Core Proteins / Q000378:metabolism*
D011991:Receptors, Virus; D014758:Viral Core Proteins