title: Assessing the relationship between environmental lead concentrations and adult blood lead levels.
abstract: This paper presents a model for predicting blood lead levels in adults who are exposed to elevated environmental levels of lead. The model assumes a baseline blood lead level based on average blood lead levels for adults described in two recent U.S. studies. The baseline blood level in adults arises primarily from exposure to lead in diet. Media-specific ingestion and absorption parameters are assessed for the adult population, and a biokinetic slope factor that relates uptake of lead into the body to blood lead levels is estimated. These parameters are applied to predict blood lead levels for adults exposed to a hypothetical site with elevated lead levels in soil, dust and air. Blood lead levels ranging from approximately 3-57 micrograms/dl are predicted, depending on the exposure scenarios and assumptions.
authors.affiliation: Gradient Corporation, Cambridge, Massachusetts 02138.
authors.forename: T S
authors.initials: TS
authors.lastname: Bowers
authors.forename: B D
authors.initials: BD
authors.lastname: Beck
authors.forename: H S
authors.initials: HS
authors.lastname: Karam
mesh_terms: D000042:Absorption; D000328:Adult; D000393:Air Pollutants / Q000032:analysis; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007700:Kinetics; D007854:Lead / Q000032:analysis* / Q000493:pharmacokinetics*; D008297:Male; D008954:Models, Biological; D012989:Soil Pollutants / Q000032:analysis; D014876:Water Pollution / Q000032:analysis
chemical_list: D000393:Air Pollutants; D004391:Dust; D012989:Soil Pollutants; D007854:Lead