title: Anaesthesia for electroconvulsive therapy: use of propofol revisited.
abstract: In three clinically depressed patients undergoing repeated electroconvulsive therapy (ECT) with either propofol or methohexitone, dose-dependent decreases in the duration of motor and EEG seizure activity were noted. Use of a 'minimally' hypnotic dose of propofol (0.75-1.0 mg kg-1) was associated with a seizure duration which was comparable to standard hypnotic doses of methohexitone. We conclude that doses of propofol < 1.5 mg kg-1 are associated with a clinically acceptable duration of EEG seizure activity (> 30 s) during ECT.
authors.affiliation: Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Centre, Dallas 75235-9068.
authors.forename: B
authors.initials: B
authors.lastname: Fredman
authors.forename: M M
authors.initials: MM
authors.lastname: Husain
authors.forename: P F
authors.initials: PF
authors.lastname: White
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001714:Bipolar Disorder / Q000628:therapy; D003866:Depressive Disorder / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004565:Electroconvulsive Therapy; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008723:Methohexital / Q000008:administration & dosage / Q000494:pharmacology; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology; D011618:Psychotic Disorders / Q000628:therapy; D012640:Seizures / Q000503:physiopathology; D013997:Time Factors
chemical_list: D008723:Methohexital; D015742:Propofol