title: [Preclinical studies for development of anti-cancer drugs: current and historical status and problems].
abstract: In this review, we present the current and historical status of preclinical studies for development of new anti-cancer drugs. In our company, especially focusing on the stage of drug screening, pharmacology, toxicology and pharmacokinetic studies. We have discovered numerous new compounds with anti-cancer potential mainly with microbial origins, from which some drugs have been developed to clinical trials. We hope that clinical trials of drugs with a new mode of action will be designed and conducted with a more rational basis, and followed by analysis of the pharmacokinetics and pharmacodynamics so as to predict the toxicity and efficacy of the drugs in humans.
authors.affiliation: Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
authors.forename: M
authors.initials: M
authors.lastname: Okabe
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Hirata
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: J
authors.initials: J
authors.lastname: Ikegami
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Komuro
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D004285:Dogs; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats
chemical_list: D000970:Antineoplastic Agents