title: Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.
abstract: The structures of the M110 and M21 regulatory subunits of protein phosphatase-1M, the major enzyme which dephosphorylates myosin in smooth muscle, have been deduced from cloned cDNAs. The N-terminus of the M110 subunit from rat aorta contains seven ankyrin repeats, while the C-terminus of the M21 subunit from chicken gizzard contains a leucine zipper motif. The M110 subunit is expressed in two different forms which differ in their C-terminal sequences. One of these is highly homologous to the whole of the M21 subunit.
authors.affiliation: Department of Biochemistry, University of Dundee, Scotland, UK.
authors.forename: Y H
authors.initials: YH
authors.lastname: Chen
authors.forename: M X
authors.initials: MX
authors.lastname: Chen
authors.forename: D R
authors.initials: DR
authors.lastname: Alessi
authors.forename: D G
authors.initials: DG
authors.lastname: Campbell
authors.forename: C
authors.initials: C
authors.lastname: Shanahan
authors.forename: P
authors.initials: P
authors.lastname: Cohen
authors.forename: P T
authors.initials: PT
authors.lastname: Cohen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta; D002645:Chickens; D003001:Cloning, Molecular; D018076:DNA, Complementary; D005895:Gizzard, Avian; D016350:Leucine Zippers / Q000235:genetics; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000201:enzymology*; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D051381:Rats; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D010749:Phosphoprotein Phosphatases