title: Unbiased estimates of the number of nucleotide substitutions when substitution rate varies among different sites.
abstract: When the number of nucleotides examined is relatively small, the estimators of nucleotide substitutions between DNA sequences often introduce systematic error even if the data used fit the mathematical model underlying the estimation formula. The systematic error of this kind is especially large for models that allow variation in substitution rate among different sites. In the present paper we present a number of formulas that produce virtually bias-free estimates of evolutionary distances for these models.
authors.affiliation: Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802.
authors.forename: A
authors.initials: A
authors.lastname: Rzhetsky
authors.forename: M
authors.initials: M
authors.lastname: Nei
mesh_terms: D000595:Amino Acid Sequence; D015982:Bias; D005075:Biological Evolution; D001699:Biometry; D004247:DNA / Q000235:genetics*; D008957:Models, Genetic
chemical_list: D004247:DNA