Biomaterials for blood-contacting applications.
Consideration of biomaterials for blood-contacting applications should take into account blood-biomaterial interactions, factors influencing the blood response and evaluation procedures. Examination of blood-biomaterial interactions indicates that relevant features are protein adsorption, platelet reactions, intrinsic coagulation, fibrinolytic activity, erythrocytes, leucocytes and complement activation. Factors influencing the blood response to a biomaterial in clinical application are the biomaterial structure, the presence of an antithrombotic agent, the patient status as determined by the disease and drug therapy, and the nature of the application. Evaluation options for biomaterials are clinical, in vivo, ex vivo and in vitro, with ex vivo and in vitro procedures relevant for biomaterial development.
Courtney
J M
JM
Bioengineering Unit, University of Strathclyde, Glasgow, UK.
Lamba
N M
NM
Sundaram
S
S
Forbes
C D
CD
D001672:Biocompatible Materials / Q000378:metabolism* / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects* / Q000378:metabolism*; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D003167:Complement Activation / Q000187:drug effects; D006801:Humans
D001672:Biocompatible Materials; D001798:Blood Proteins