The effect of the humoral immune system-derived bursal anti-steroidogenic peptide (BASP) on corticosteroid biosynthesis in avian, porcine and canine adrenal cortical cells.
Utilizing avian, porcine and canine adrenocortical cells, we have examined the effect of bursal anti-steroidogenic peptide (BASP) on adrenocorticotropin (ACTH) and dibutyryl cyclic AMP (DB-cAMP)-stimulated corticosteroid and cAMP formation. BASP significantly (P < 0.05) suppressed corticosteroid production from adrenocortical cells derived from chickens, pigs and dogs. BASP significantly increased cAMP formation (up to 10-fold) in a dose-related manner. These findings suggest that BASP structure and activity may be conserved between chicken, porcine and canine species.
Byrd
J A
JA
Department of Poultry Science, Texas A & M University System, College Station 77843.
Dean
C E
CE
Hargis
B M
BM
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002060:Bursa of Fabricius / Q000378:metabolism*; D002645:Chickens / Q000502:physiology; D003345:Corticosterone / Q000096:biosynthesis*; D003470:Culture Media; D000242:Cyclic AMP / Q000096:biosynthesis*; D004285:Dogs / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D011863:Radioimmunoassay; D013329:Structure-Activity Relationship; D013552:Swine / Q000502:physiology
D003470:Culture Media; D010455:Peptides; D003994:Bucladesine; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D003345:Corticosterone