string of pearls encodes Drosophila ribosomal protein S2, has Minute-like characteristics, and is required during oogenesis.
The first allele of string of pearls (sop) was isolated as a recessive female sterile mutant in a P element enhancer trap screen. Oogenesis in homozygous sop females arrests at approximately stage 5. In addition, homozygous flies of both sexes have Minute-like characteristics that include reduced bristles, delayed development and larval lethality. sop maps to 30D/E on chromosome 2L and encodes the Drosophila homolog of eukaryotic ribosomal protein S2. The gene is present in a single copy in the Drosophila genome and the level of mRNA present in mutant animals is reduced. The identification of a mutant allele that blocks development at a mid-stage of oogenesis may indicate that sop has a specific developmental role during oogenesis in addition to its general role in protein synthesis as a component of the small ribosomal subunit.
Cramton
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Department of Biology, University of California, Los Angeles 90024.
Laski
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D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D017344:Genes, Insect; D005808:Genes, Recessive; D007247:Infertility, Female / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009866:Oogenesis / Q000235:genetics*; D010641:Phenotype; D012269:Ribosomal Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D012269:Ribosomal Proteins; C030004:ribosomal protein S2