Utility of an excluded and everted segment of small intestine placed under the skin of the abdominal wall as an adrenal transplant site in rats.
The feasibility of excluded and everted small intestine segments as reservoirs for adrenal tissue transplantation was compared between biadrenalectomized adult rats with isogenic transplants of adrenal quarters or allogenic transplants of neonatal adrenal glands. Small clusters of adrenocortical cells, located between the adipocytes and the mesenteric vessels of the segments' lumen, were observed following isogenic transplantation. Several large regenerated adrenocortical nodules, surrounded by a connective capsule, were present in each of the rats transplanted with neonatal adrenal glands. Medullary tissue did not regenerate. It was concluded that the excluded and everted segments of small intestine were optimal sites for adrenal tissue transplantation and that the regeneration process of the adrenocortical tissue takes place more quickly after the transplantation of neonatal adrenal glands than after the transplantation of adrenal quarters.
Losada
J
J
Department of Surgery, School of Medicine and Dentistry, University of the Basque Country, Spain.
Sarria
R
R
Doñate-Oliver
F
F
D000009:Abdominal Muscles; D000311:Adrenal Glands / Q000033:anatomy & histology / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D005240:Feasibility Studies; D005260:Female; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology