title: Primary extramedullary plasmacytoma in the middle ear: differential diagnosis and management.
abstract: Primary extramedullary plasmacytoma (PEP) is an uncommon neoplasm of plasma cell origin which afflicts the head and neck mainly. In this study we report a rare case of a 34-year-old man who presented with left ear tinnitus, hearing loss, blocked feeling and headache. Exploratory tympanotomy revealed a mass extending into the attic and the mastoid antrum. Following canal wall-up mastoidectomy, the tumour was carefully removed. Histological examination (including immunoperoxidase staining) and thorough clinical, laboratory and radiological evaluation revealed an exclusively cytoplasmic monoclonal IgG immunoglobulin PEP. The combination of surgery (including a second-look procedure) and radiotherapy used in this case may be an over-treatment. However, the patient is still disease-free seven years after his first admission to hospital.
authors.affiliation: Department of Otolaryngology, Athens University School of Medicine, Greece.
authors.forename: D C
authors.initials: DC
authors.lastname: Kandiloros
authors.forename: T P
authors.initials: TP
authors.lastname: Nikolopoulos
authors.forename: E A
authors.initials: EA
authors.lastname: Ferekidis
authors.forename: A N
authors.initials: AN
authors.lastname: Kaloterakis
authors.forename: C P
authors.initials: CP
authors.lastname: Papadimitriou
authors.forename: G K
authors.initials: GK
authors.lastname: Adamopoulos
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004428:Ear Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D004432:Ear, Middle / Q000473:pathology*; D006801:Humans; D008297:Male; D010954:Plasmacytoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery