Pharmacology of alpha-glucosidase inhibition.
The development of alpha-amylase and brush-border alpha-glucosidase inhibitors is reviewed. The mode of action as well as pharmacological and pharmacodynamic properties of selected inhibitors with special regard to the most thoroughly investigated alpha-glucosidase inhibitor acarbose are discussed. Inhibition of intestinal alpha-glucosidases delays the digestion of starch and sucrose, flattens the postprandial blood glucose excursions, and thus mimics the effects of dieting on hyperglycaemia, hyperinsulinaemia and hypertriglyceridaemia. Therefore, the mechanism of alpha-glucosidase inhibition represents the pharmacological optimization of the dietary principle of delayed carbohydrate absorption. In pre-clinical studies using diabetic animals the oral administration of acarbose improved the metabolic state and reduced the blood glucose area under the curve. As a consequence, the process of non-enzymatic glycation of proteins was retarded as indicated by reduced glycated haemoglobin, glomerular basement membranes or advanced glycation end-products (AGEs) in collagen. These improved biochemical parameters correlated with beneficial effects against the development of diabetic nephropathy and neuropathy. Thus, the treatment of diabetic animals with acarbose does not only improve the metabolic state but has also the potential to delay, or possibly prevent, the development of diabetic complications.
Bischoff
H
H
Institute for Cardiovascular and Arteriosclerosis Research, Wuppertal, Germany.
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D020909:Acarbose; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002240:Carbohydrate Sequence; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000517:prevention & control; D003929:Diabetic Neuropathies / Q000517:prevention & control; D004040:Dietary Carbohydrates; D004063:Digestion; D005944:Glucosamine / Q000031:analogs & derivatives / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008969:Molecular Sequence Data; D014312:Trisaccharides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D017127:Glycation End Products, Advanced; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007328:Insulin; D014312:Trisaccharides; D017485:1-Deoxynojirimycin; D005944:Glucosamine; C045622:emiglitate; D020909:Acarbose