title: Acute urticaria and hepatitis complicating high-dose methotrexate therapy.
abstract: We report an unusual case of anaphylaxis and hepatitic dysfunction in a child with the administration of the twenty-third course of high-dose methotrexate. The latter had been used as an adjuvant to prevent pulmonary metastases and the prior 22 courses had been well tolerated. An attempt to reinstate methotrexate after the twenty-third course was again followed by a similar reaction.
authors.affiliation: Department of Child Health, College of Medicine, Sultan Qaboos University Hospital, Sultanate of Oman.
authors.forename: Z
authors.initials: Z
authors.lastname: al-Lamki
authors.forename: E
authors.initials: E
authors.lastname: Thomas
authors.forename: N
authors.initials: N
authors.lastname: el-Banna
authors.forename: N
authors.initials: N
authors.lastname: Jaffe
mesh_terms: D000208:Acute Disease; D001859:Bone Neoplasms / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D012516:Osteosarcoma / Q000188:drug therapy; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D008727:Methotrexate