Report of a case of sympathetic ophthalmia with special regard to ultrastructural examination.
A case of sympathetic ophthalmia (SO) is reported. A long lasting stable result was obtained for this patient treated basically with traditional Chinese medicine. His exciting eye was investigated under light and transmission electron microscopes. Prominent granulomatous lesions in the choroid, Dalen-Fuchs nodules (DFNs) and disruption of outer and inner basement membrane of Bruch's membrane under DFNs are found, plasma cells are not few and melanocytes and retinal pigment epithelial cells are possibly the target cells. In various cells, nuclear bodies (NBs) are ubiquitous and sometimes multiple in an individual cell nucleus. Microtubule-like structures are present inside and outside the NBs and parallel lines composed of relatively uniform high electron dense granules as lattice-like structures can be seen. It was surmised that a virus induced autoimmune process might be involved in the pathogenesis of SO.
Bao
L L
LL
Ophthalmology Department, 1st Teaching Hospital, Shanxi Medical College, Taiyuan.
Yang
J S
JS
Xiao
J
J
Ma
X H
XH
D000328:Adult; D001327:Autoimmune Diseases; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009879:Ophthalmia, Sympathetic / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure*; D014602:Uvea / Q000648:ultrastructure*; D014777:Virus Diseases
D004365:Drugs, Chinese Herbal