Effect of Astragalus membranaceus on electrophysiological activities of acute experimental Coxsackie B-3 viral myocarditis in mice.
A murine model for observing the effect of Astragalus membranaceus (AM) on electrophysiological action of the right ventricular myocardium was developed in 4-week-old male BALB/c mice infected with coxsackie B-3 virus (CB3V). The conventional microelectrode technique and a real-time data processor system were used. The survival rate in AM-treated mice was much higher and the percentage of abnormal action potential was much lower than those in infected control mice (P < 0.05, P < 0.01, respectively). Some abnormal electrophysiological parameters, such as APA, OS and Vmax, in infected myocardium were found to be improved by AM treatment. The results suggest that AM may be valuable in the prevention and treatment of acute viral myocarditis involving coxsackie B viruses.
Affiliated Hospital of Zhenjiang Medical College.
T
T
Rui
Y
Y
Yang
T
T
Zhou
J
J
Zhang
X
X
Yang
H
H
Chen
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D027885:Astragalus propinquus; D016009:Chi-Square Distribution; D003384:Coxsackievirus Infections / Q000188:drug therapy / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004594:Electrophysiology; D029822:Enterovirus B, Human; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000188:drug therapy / Q000503:physiopathology*; D011897:Random Allocation
D004365:Drugs, Chinese Herbal