Expression and gene sequence of outer surface protein C of Borrelia burgdorferi reisolated from chronically infected mice.
OspC from Borrelia burgdorferi reisolated from mice persistently infected with cloned spirochetes was examined. In all cases, the sequence of the ospC gene was identical to that of the original inoculant. We conclude that variation of ospC is not necessary for evasion of the host immune system.
Stevenson
B
B
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520.
Bockenstedt
L K
LK
Barthold
S W
SW
D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis / Q000235:genetics*; D001483:Base Sequence; D015748:Borrelia burgdorferi Group / Q000235:genetics* / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D001425:Bacterial Outer Membrane Proteins