[Detection and localization of parathyroid adenomas and hyperplasias in patients with hyperparathyroidism using thallium-201/technetium-99m parathyroid subtraction scintigraphy].
201Tl/99mTc subtraction scintigraphy (TTS) has been recognized as a useful procedure in the preoperative localization of hyperfunctioning parathyroid glands. Ninety-one patients suspected of hyperparathyroidism (HPT) were studied with TTS for the localization of lesions and 59 patients out of those had a neck exploration and parathyroidectomy which allowed for clinical correlation of pathologic findings with the imaging results. The weight of 30 glands of adenoma ranged 0.100 to 11.700 g (1.840 +/- 0.446 g (mean +/- SE)). The weight of 88 glands of hyperplasia ranged 0.025 to 7.000 g (0.623 +/- 0.100 g). Overall sensitivity and specificity were 47% and 54%, respectively. The sensitivity for the adenoma and the hyperplasia was 87% and 33%, respectively. The specificity for them was 57% and 52%. There was significant difference for the detection between adenomas and hyperplasias. TTS is more useful for the localizing diagnosis of parathyroid adenomas than parathyroid hyperplasia in a patient with hyperfunctioning parathyroid state.
Kanegae
K
K
Department of Nuclear Medicine, Hokkaido University, School of Medicine.
Itoh
K
K
Kato
C
C
Nagao
K
K
Nakada
K
K
Fujimori
K
K
Furudate
M
M
D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging; D006962:Hyperparathyroidism, Secondary / Q000000981:diagnostic imaging*; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000000981:diagnostic imaging* / Q000473:pathology*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D013667:Technetium; D013794:Thallium Radioisotopes
D013794:Thallium Radioisotopes; D013667:Technetium