Response to suxamethonium during propofol-fentanyl-N2O/O2 anaesthesia in a patient with active myasthenia gravis receiving long-term anticholinesterase therapy.
We describe the effect of repeated suxamethonium doses during propofol-fentanyl-N2O/O2 anaesthesia in a 29-year-old woman with active myasthenia gravis receiving chronic pyridostigmine therapy. Despite adequate pre-operative pseudocholinesterase activity, suxamethonium resistance occurred. Neither bradycardia nor residual neuromuscular block were seen after repeated doses of suxamethonium.
Vanlinthout
L E
LE
Institute for Anaesthesiology, University Hospital of Nijmegen, The Netherlands.
Robertson
E N
EN
Booij
L H
LH
D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009157:Myasthenia Gravis / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology / Q000601:surgery; D009609:Nitrous Oxide; D010100:Oxygen; D015742:Propofol; D011729:Pyridostigmine Bromide / Q000627:therapeutic use*; D013390:Succinylcholine / Q000494:pharmacology*
D013390:Succinylcholine; D009609:Nitrous Oxide; D011729:Pyridostigmine Bromide; D010100:Oxygen; D015742:Propofol