[Inhibitory effect on anti-lipid IV antiserum binding activity of various synthetic oligosaccharides].
The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Me beta 1-4Fuc of lipid IV, inhibited but precursors (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
N
N
Hada
M
M
Sugita
T
T
Takeda
T
T
Maki
Y
Y
Ogihara
D020384:Acidic Glycosphingolipids; D003864:Depression, Chemical; D006028:Glycosphingolipids / Q000276:immunology*; D007106:Immune Sera / Q000378:metabolism*; D008968:Molecular Conformation; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D020384:Acidic Glycosphingolipids; D006028:Glycosphingolipids; D007106:Immune Sera; C037242:Lipid IV; D009844:Oligosaccharides