Uptake and clearance of diazinon in different tissues of the European eel (Anguilla anguilla L.).
Acute toxicity effects of diazinon on European eel (Anguilla anguilla) was examined using short-term exposures in static conditions. The LC50 values were 0.16, 0.11, 0.09 and 0.08 mg/l at 24, 48, 72 and 96 h exposure, respectively. In addition, the eels were exposed to 0.042 mg/l of diazinon and bioaccumulation and clearance processes of this insecticide in liver, muscle and gill tissues were studied. Bioconcentration factor (BCF) of diazinon over 96 h exposure period was 1850 in liver, 875 in gill and 775 in muscle tissue. Diazinon elimination from the selected tissues was rapid. The excretion rate constants of this insecticide were 0.108 h-1 for liver, 0.055 h-1 for gill and 0.016 h-1 for muscle. Diazinon half-lives were calculated as 16.6, 33.2 and 27 h for liver, muscle and gill, respectively. Diazinon showed relatively short half-lives in eel tissues.
Department of Animal Physiology, Faculty of Biological Sciences, University of Valencia, Spain.
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Sancho
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Ferrando
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Gamón
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Andreu-Moliner
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003976:Diazinon / Q000493:pharmacokinetics* / Q000633:toxicity; D004524:Eels / Q000378:metabolism*; D004781:Environmental Exposure; D006207:Half-Life; D007928:Lethal Dose 50; D013997:Time Factors; D014018:Tissue Distribution
D003976:Diazinon