[The enzymatic activity of the neurosecretory nuclei of the anterior hypothalamus in exposure of the body to organophosphorus compounds].
Under study were activities of glycolysis enzymes: LDH, Krebs' cycle--SDH, those of electron transport system--NAD and NADP-diaphorase, and of the hydrolytic enzymes, acid and alkaline phosphatases in the hypothalamus, as were morphofunctional shifts in these enzymes' activities in poisoning with organophosphorus compounds. The experiments were carried out in 72 white male outbred rats weighing 180-200 g, that were administered PHOS antio (an organo-phosphorus compound) in a daily dose of 0.1 LD50 for 30 days. Early dates of poisoning were associated with an essential rise of the redox enzymes and a lowering of the hydrolytic enzymes levels, this being paralleled by morphologic signs of activation of the neurosecretory cells. Later high levels of neurosecretory material in the neurosecretory nuclei and reduced counts of neurosecretory cells were coupled with almost all the enzymes' activities lowering. This permits a conclusion that changed activities of the enzymic systems may be one of the pathogenetic mechanisms and possible causes of neurosecretory cell dysfunction in pesticide poisonings.
N K
NK
Shamsieva
A A
AA
Khusinov
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000187:drug effects* / Q000201:enzymology* / Q000473:pathology; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000201:enzymology* / Q000473:pathology; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011041:Poisoning / Q000201:enzymology / Q000473:pathology; D051381:Rats; D013997:Time Factors
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C067599:formothion
Aktivnost' fermentov neĭrosekretornykh iader perednego gipotalamusa pri vozdeĭstvii na organizm fosfororganicheskikh soedineniĭ.