Clinical evaluation of Tc-99m cystine. A new renal radiopharmaceutical.
Tc-99m cystine has been proven to be a good renal agent in animals, but its clinical evaluation has not been reported. In this study, Tc-99m cystine was used for evaluation of renal function in normal subjects and patients with chronic renal failure as well as in renal transplant patients. The results are compared with similar studies that used Tc-99m DTPA and Tc-99m GHA. The clearance values also have been compared with I-131 OIH clearance. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.
Misra
M
M
Department of Nuclear Medicine, Indian Institute of Chemical Biology, Calutta.
Das
B K
BK
Gambhir
S
S
Mittal
B R
BR
Sewatkar
A B
AB
Ghosh
S
S
Banerjee
S N
SN
D003553:Cystine / Q000031:analogs & derivatives*; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography; D013400:Sugar Acids; D016284:Technetium Tc 99m Pentetate
D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D013400:Sugar Acids; C060718:technetium Tc 99m cystine; D007465:Iodohippuric Acid; D003553:Cystine; C100014:technetium Tc 99m gluceptate; D016284:Technetium Tc 99m Pentetate