Exposure of intestinal segments to hemiacidrin: analysis of metabolic and histological effects using a rat model.
Using a previously reported rat model, we examined the effects of intestinal perfusion with hemiacidrin on calcium and magnesium homeostasis, and inspected the intestinal segments for histological alterations following exposure to the solution. Intestinal irrigation with hemiacidrin resulted in a significant increase in serum magnesium. Urinary excretion rates of calcium increased 8-fold and magnesium excretion rates increased 5-fold over control values. Hemiacidrin appeared to have detrimental effects on the integrity of the intestinal mucosa, and irrigation should be done with caution in patients whose urinary tract has been reconstructed with intestinal segments.
Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2765.
R A
RA
Brandell
M C
MC
Hall
M O
MO
Koch
H V
HV
Braren
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D007507:Therapeutic Irrigation; D014547:Urinary Diversion
D002951:Citrates; C026485:hemiacidrin; D008274:Magnesium; D002118:Calcium