[Treatment with GnRH analogs in polycystic ovarian disease. A collaborative multicenter study. The preliminary results].
The study evaluates the efficacy of tryptorelin treatment in cases of acne and hirsutism associated with polycystic ovarian (PCO) disease. This non-comparative open study in a sample population of 20 young patients who wished to have children demonstrates the reduction of the hirsutism and acne score after six months' treatment. Tryptorelin was even capable of normalizing the hematic hormonal levels examined and ovarian function following six months of treatment, as well as at an initial follow-up after three months. The authors state their intention of performing a larger trial in order to observe the real efficacy of tryptorelin in a study which includes a 12-month follow-up to assess the pregnancy rate.
Divisione di Ostetricia e Ginecologia, Ospedale L. Sacco, Milano.
L
L
Cipolla
R
R
Zagni
B
B
Ferrante
G
G
Giannetta
A
A
Soliani
D000152:Acne Vulgaris / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006628:Hirsutism / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000627:therapeutic use
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone
Il trattamento con analoghi del GnRH della malattia policistica dell'ovaio. Studio policentrico collaborativo. Risultati preliminari.