[Morphogenesis of experimental neuroleukemia].
22 mice with L-1210 leukemia treated with quinoline dibromide were studied histologically. Two ways of the development of leptomeningeal infiltrates in the brain are established. The first is due to the growth of uninhibited by treatment bone-marrow leukemic infiltrates (LI) of the skull, while the second-when the above infiltrates are suppressed-due to the proliferation of leukemic cells penetrating from the dura mater to the leptomeninges protected by the hematoencephalic barrier from the effect of anticancer drugs. when the recurrence of leukemia occurs the growth of bone-marrow LI continues resulting in the additional migration of leukemic cells to the leptomeninges. These ways of the leptomeninx LI formation should be taken into consideration in the leukemia treatment.
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Petrov
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001099:Arachnoid / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004388:Dura Mater / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D009024:Morphogenesis; D010841:Pia Mater / Q000187:drug effects; D011804:Quinolines / Q000627:therapeutic use*; D012008:Recurrence
D000970:Antineoplastic Agents; D011804:Quinolines; D008727:Methotrexate
Morfogenez éksperimental'nogo neĭroleĭkoza.