[A comparative analysis of the effect of alpha 2-interferon (reaferon) therapy on the morphofunctional state of the bone marrow in patients with chronic myeloleukemia].
Marrow trepan biopsy was performed in 11 patients upon diagnosis of chronic myeloid leukemia and in clinicohematological remission of the disease. The patients were treated with alpha 2-interferon (reaferon) versus conventional myelosan (6 and 5 patients, respectively). The biopsies were studied histomorphometrically. In reaferon group the number of megakaryocytes and endosteal stromal cells diminished. This may be due to an indirect action of reaferon on hemopoietic tissue via endosteal cells of the marrow stroma. Reaferon is recommended for myeloid leukemia chronic with a granulocytic-megakaryocytic histological variant of the disease.
Abdulkadyrov
K M
KM
Rukavitsyn
O A
OA
Moiseev
S I
SI
Rugal'
V I
VI
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000187:drug effects* / Q000503:physiopathology; D001856:Bone Marrow Examination; D002066:Busulfan / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D002066:Busulfan
Sravnitel'yĭ analiz vliianiia terapii al'fa 2-interferonom (reaferonom) na morfofunktsional'noe sostoianie kostnogo mozga u bol'nykh khroniceskim mieloleĭkozom.