Lack of effect of H2-receptor antagonists on the pharmacokinetics of alcohol consumed after food at lunchtime.
The possibility of a pharmacokinetic interaction between H2-receptor antagonists and alcohol consumed at lunchtime, was investigated in 24 healthy non-alcoholic male subjects, each receiving ranitidine 150 mg four times daily, cimetidine 400 mg four times daily, famotidine 20 mg four times daily and placebo in an open, four-way cross-over study. The subjects consumed 50 g alcohol after a standard lunch on the eighth day of dosing with study medication. Blood samples taken during the 6 h after alcohol consumption were analysed for alcohol concentrations by gas liquid chromatography using head space analysis. None of the H2-receptor antagonists had any statistically significant effects on any of the pharmacokinetic parameters for alcohol. Mean Cmax (95% CI) results for ranitidine were 547 (516, 580), cimetidine 531 (501, 563), famotidine 563 (530, 598) and placebo 529 (499, 561) mg l-1.
Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham.
M J
MJ
Kendall
F
F
Spannuth
R P
RP
Walt
G J
GJ
Gibson
K A
KA
Hale
R
R
Braithwaite
M J
MJ
Langman
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D015738:Famotidine / Q000494:pharmacology*; D005502:Food; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine