[Diethyl benzylpiperazinomethyl and benzylpiperazinomethylbenzyl phosphonates as calcium inhibitors].
Two sets of phosphonic diethylester including a substituted benzylpiperazine moiety are synthesized. In spite of the spasmolytic or the calcium antagonistic potentialities of benzylpiperazine and phosphonic moieties, none of the six compounds, tested in vitro, exhibit any calcium antagonistic profile.
Faculté de Pharmacie, Toulouse.
S
S
Younes
G
G
Baziard-Mouysset
J L
JL
Stigliani
M
M
Payard
R
R
Bonnafous
J
J
Tisne-Versailles
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits
D002121:Calcium Channel Blockers; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C088413:diethyl benzylpiperazinomethylphosphonate; C088414:diethyl benzylpiperazinomethylbenzylphosphonate
Benzylpipérazinométhyl et benzylpipérazinométhylbenzyl phosphonates de diéthyle à visée inhibitrice calcique.