[Anionic site changes on glomerular basement membrane (GBM) in proteinuria rats].
The change of anionic sites on GMB was studied in both adriamycin induced nephrosis and nephrotoxic serum nephritis in rats by means of calculating the PEI stained particles under electron microscope. The results showed that the number of anionic sites within lamina rara externa of GMB was reduced significantly in both kinds of proteinuria rats and the size of anionic sites was also changed, especially in the segments of GBM with fused foot processes. The results demonstrate that the loss of anionic sites on GBM and the functional damage to the charge selective barrier of glomeruli may play an important role in proteinuria of these animal models.
Department of Pediatrics, Second Affiliated Hospital, Hubei Medical University, Wuhan.
Z Y
ZY
Chen
L P
LP
Li
D000818:Animals; D000838:Anions; D001485:Basement Membrane / Q000648:ultrastructure; D004317:Doxorubicin; D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure*; D007106:Immune Sera; D009393:Nephritis / Q000473:pathology; D009401:Nephrosis / Q000139:chemically induced / Q000473:pathology*; D011507:Proteinuria / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000838:Anions; D007106:Immune Sera; D004317:Doxorubicin