Deficiency of both protein C and protein S in a family with ischemic strokes in young adults.
Protein C and protein S deficiencies increase the risk of venous thrombosis and pulmonary embolism, but their role in arterial thrombosis or embolism is controversial. We describe cerebral ischemia in two young women in a family with inherited deficiencies of both proteins C and S and provide evidence that a combined deficiency of proteins C and S may be a high risk factor for ischemic stroke in young adults.
Köller
H
H
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
Stoll
G
G
Sitzer
M
M
Burk
M
M
Schöttler
B
B
Freund
H J
HJ
D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000150:complications* / Q000235:genetics*; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020151:Protein C Deficiency; D018455:Protein S Deficiency