[Results of monotherapy in mild and drug-resistant forms of epilepsy].
Monotherapy with one drug chosen out of basic anti-epileptic agents was carried out in 312 patients, including 2/3 of cases resistant to the drugs. Group A consisted of 110 patients treated with a single drug since the onset of the disease whereas group B consisted of 202 patients in whom polytherapy was reduced to monotherapy. The best results were achieved in patients of group A with short and medium duration of the disease. The results noted in patients of group B were worse and independent of the duration of epilepsy. The most favourable effects were noted in children with mild epilepsy and generalized epilepsy of unknown post-traumatic etiology. The results of monotherapy in focal seizures and epilepsy with organic lesions were markedly worse. The most effective drugs in this population were: barbiturates, valproic acid derivatives, and carbamazepine. The authors stress that all forms of epilepsy, especially newly diagnosed and previously untreated cases, should be treated with single agent.
Bacia
T
T
Pracowni Elektroencefalografii i Neurofizjologii Klinicznej Kliniki Neurochirurgii AM, Warszawie.
Bendarzewska-Nawrocka
B
B
Urbaniak
J W
JW
D000293:Adolescent; D000328:Adult; D000368:Aged; D001463:Barbiturates / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use
D001463:Barbiturates; D002220:Carbamazepine; D014635:Valproic Acid
Wyniki monoterapii w łagodnych i lekoopornych formach padaczek.