Technetium-99m labelling of bis-oxime ligands.
The synthesis and labelling of a new bis-amide-oxime ligand E,E-2,9-bis(hydroxyimino)-4,7-diaza 5,6-dioxodecane (AdO) with 99mTc has been achieved. Protein binding, partition coefficient and tissue distribution of this complex and two related bis-amine-oxime ligands is reported. The biodistribution of the complexes are disappointing with only limited brain and myocardial uptake. Structures for the complex are postulated.
Jackson
G E
GE
Department of Chemistry, University of Cape Town, South Africa.
Byrne
M J
MJ
Fakier
H
H
Hunter
R
R
Woudenberg
M
M
D000818:Animals; D004590:Electrophoresis, Paper; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010091:Oximes / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013667:Technetium / Q000737:chemistry*; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D010091:Oximes; D012710:Serum Albumin, Bovine; D013667:Technetium