Pharmacokinetics and tissue distribution of iomeprol in animals.
The pharmacokinetics of iomeprol, a new triiodinated nonionic radiographic contrast agent, has been studied in rats, rabbits and dogs. Following intravenous administration, iomeprol did not bind measurably to plasma proteins and was rapidly excreted in unchanged form, mostly through the kidneys. The compound was rapidly distributed to the plasma and thence to the extracellular spaces. Iomeprol did not accumulate in specific organs or tissues except for those involved in its elimination, i.e. the kidneys and the liver. However, 24 h after administration, less than 1% of the injected dose remained in the tissues. The overall profile was very similar to the published profiles of other radiographic contrast agents used in uroangiography.
Research and Development Division, Bracco SpA, Milan, Italy.
V
V
Lorusso
F
F
Luzzani
F
F
Bertani
P
P
Tirone
C
C
de Haën
D000818:Animals; D001646:Bile / Q000378:metabolism; D001769:Blood; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003287:Contrast Media / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D004285:Dogs; D005243:Feces / Q000737:chemistry; D005260:Female; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics; D008297:Male; D008892:Milk / Q000737:chemistry / Q000378:metabolism; D011247:Pregnancy; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000378:metabolism; D014018:Tissue Distribution; D014556:Urine
D003287:Contrast Media; D007457:Iodine Radioisotopes; D012709:Serum Albumin; C057937:iomeprol; D007479:Iopamidol