Effects of ilexonin A on cAMP metabolism in platelets.
Ilexonin A (Ile A) is an effective compound isolated from Ilex pubescens Hook et Arn which has been found to inhibit platelet aggregation and Ca2+ influx in platelets. The present experiments were designed to observe the effects of Ile A on platelet metabolism. Verapamil (Ver) was used as control. The results indicated that thrombin significantly reduced the level of platelet cAMP, while Ile A and Ver obviously antagonized this effect. The inhibition of the activity of platelet phosphodiesterase by Ile A was much stronger than that by Ver. The results suggest that Ile A may be beneficial in the treatment of cardiovascular disease.
Institute of Basic Medical Sciences, CAMS, Beijing.
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D000262:Adenylyl Cyclases / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000097:blood*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006801:Humans; D009930:Organic Chemicals; D010727:Phosphoric Diester Hydrolases / Q000097:blood; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors; D014700:Verapamil / Q000494:pharmacology
D005343:Fibrinolytic Agents; D009930:Organic Chemicals; D010975:Platelet Aggregation Inhibitors; C043587:ilexonin A; D014700:Verapamil; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D013917:Thrombin; D000262:Adenylyl Cyclases