Modeling the impact and cost-effectiveness of HIV prevention efforts.
OBJECTIVE
This study explores how mathematical models can be used to examine the relationship between the effectiveness and costs of different prevention strategies. The analysis, based on a model designed to simulate the spread of HIV in sub-Saharan Africa, illustrates how the impact and relative cost-effectiveness of a prevention programme are sensitive to a number of factors including the rate of spread of HIV prior to the introduction of the programme, the measure used to evaluate the impact of the programme, and the point when the programme is introduced in the epidemic.


RESULTS
Assessing the impact and cost-effectiveness of different HIV prevention strategies is problematic. Not only are there difficulties in collecting the relevant data, but the impact of a prevention programme may be highly non-linear in character because of the many factors that determine the net rate of viral transmission. The long incubation period of HIV further complicates the analysis as the benefits from preventing a case of infection extend over a number of years.


CONCLUSIONS
The results highlight the need to collect more data on the impact and costs of prevention programmes if we are to ensure that the available resources for HIV prevention are to be used both efficiently and equitably.
Biology Department, Imperial College of Science, Technology and Medicine, London, UK.
J T
JT
Rowley
R M
RM
Anderson
D017954:Africa South of the Sahara; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D005260:Female; D015658:HIV Infections / Q000191:economics* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008962:Models, Theoretical