Erythrocyte cation transport systems in insulin-dependent diabetics: correlation with prorenin and albuminuria.
The relationship between erythrocyte cation transport systems, plasma prorenin and albuminuria was examined in patients with insulin-dependent diabetes mellitus (IDDM). Different measurements of erythrocyte transport systems were obtained in patients with IDDM: Na+/Li+ countertransport; Na+/K+ cotransport and Na+/K+ ATPase pump activity. In single regression analysis the erythrocyte Na+/Li+ countertransport was positively related to the plasma prorenin level. In multiple regression analysis the erythrocyte Na+/Li+ countertransport activity was independently related to plasma prorenin, albuminuria and age. Our data in patients with IDDM show that an elevated erythrocyte Na+/Li+ countertransport is accompanied by a higher plasma prorenin level and albuminuria.
Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Belgium.
P
P
Lijnen
A
A
Fenyvesi
M
M
Bex
R
R
Bouillon
A
A
Amery
D000328:Adult; D000419:Albuminuria / Q000097:blood* / Q000378:metabolism* / Q000503:physiopathology; D017920:Antiporters / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism* / Q000503:physiopathology; D004792:Enzyme Precursors / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008094:Lithium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism*; D028021:Sodium-Potassium-Chloride Symporters; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
D017920:Antiporters; D002352:Carrier Proteins; D004792:Enzyme Precursors; D028021:Sodium-Potassium-Chloride Symporters; C045885:sodium-lithium countertransporter; D008094:Lithium; D012964:Sodium; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium