A study of the use of clonidine and naltrexone in the treatment of opioid addiction in the former USSR.
Sixty-eight opioid addicts in Moscow voluntarily entered a two phase study that employed the medications clonidine and naltrexone to withdraw addicts from narcotics and naltrexone for maintenance therapy. Of the 44 subjects entering the withdrawal phase, only 3 completed the procedure and entered naltrexone maintenance. All 27 subjects entering naltrexone maintenance left within 50 days against medical advice. Follow-up on about 75% of the subjects in both phases of the study showed they relapsed to opioid use after leaving treatment.
Department of Polysubstance Abuse, 17th Narcological Hospital, Moscow, USSR.
A
A
Azatian
A
A
Papiasvilli
H
H
Joseph
D000328:Adult; D003000:Clonidine / Q000627:therapeutic use*; D003431:Cross-Cultural Comparison; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006556:Heroin Dependence / Q000523:psychology / Q000534:rehabilitation; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use*; D009460:Neurologic Examination / Q000187:drug effects; D009293:Opioid-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D010352:Patient Dropouts / Q000523:psychology; D012008:Recurrence; D016896:Treatment Outcome; D014586:USSR
D009271:Naltrexone; D003000:Clonidine