[Current scopes on tissue factor: its physiological function and relationship with coagulation diseases].
Monocytes/macrophages and endothelial cells express tissue factor (TF), an initiator for blood clotting pathway, following their activation accompanied by immune response and/or inflammation. This TF expression results in thrombin generation and fibrin formation around these cells and possibly participates in host-defense mechanism. TF expression by these cells is also a risk-factor to vascular diseases including arteriosclerosis and thrombosis. In cancer and leukemia patients elevation of their plasma TF level associated with DIC and related coagulation disorders.
Department of Cellular and Molecular Biology, Kyoto University.
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Nakamura
D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology*; D006801:Humans; D007111:Immunity, Cellular; D013917:Thrombin / Q000378:metabolism; D013925:Thromboplastin / Q000235:genetics / Q000502:physiology*; D014652:Vascular Diseases / Q000209:etiology
D013925:Thromboplastin; D013917:Thrombin