Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus.
The neuroprotective action of brain-derived neurotrophic factor (BDNF) was evaluated in a rat model of transient forebrain ischemia. A continuous intraventricular infusion of BDNF for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable CA1 sector of the hippocampus. In situ hybridization experiments suggest the neuroprotection to be mediated via trkB-receptors in the hippocampus. The data indicate a therapeutic potential for the treatment of cerebral ischemia.
Beck
T
T
Anatomisches Institut, Universität Rostock, Germany.
Lindholm
D
D
Castrén
E
E
Wree
A
A
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009474:Neurons / Q000473:pathology; D017966:Pyramidal Cells / Q000473:pathology; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D020813:Receptor, trkB; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020813:Receptor, trkB