Plasmic levels of trace elements and immune functions in the healthy elderly.
Healthy elderly persons were selected according to an admission protocol which included clinical, hematological and biochemical parameters. Plasmic levels of zinc in these subjects were in the normal range, while plasmic copper was higher than that of young controls. The number of circulating lymphocytes and CD3+ cells was decreased; however, the absolute number of CD4+, CD8b, CD8d, CD20+ and CD57+ cells did not differ from that of controls. A decreased lymphocyte response to PHA in serum-free medium cultures was also observed in the healthy elderly persons.
Department of Experimental Pathology, University of Bologna, Italy.
F
F
Licastro
M C
MC
Morini
M
M
Chiricolo
R
R
Conte
D
D
Belletti
R
R
Mancini
E
E
Beltrandi
M
M
Casadei-Maldini
E
E
Carpenè
D000375:Aging / Q000097:blood* / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis; D003300:Copper / Q000097:blood*; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology*; D010641:Phenotype; D015032:Zinc / Q000097:blood*
D015703:Antigens, CD; D003300:Copper; D015032:Zinc