New approaches to amphibian limb regeneration.
Limb regeneration in urodele amphibians proceeds by the formation of a blastema, a growth zone of mesenchymal progenitor cells. Here, I review the origin of the blastema and its positional identity. The ability to culture and reimplant newt blastemal cells, and to transfect them in culture and in situ using a particle delivery system, has yielded new information about the action of retinoic acid on the blastema and the reversal of muscle differentiation during limb regeneration.
Ludwig Institute for Cancer Research, University College London, UK.
J P
JP
Brockes
D000818:Animals; D006614:Hindlimb / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000502:physiology; D012038:Regeneration; D014562:Caudata / Q000235:genetics / Q000502:physiology*
D018168:Receptors, Retinoic Acid