Inhibition of photohemolysis by copper(II) complexes with SOD-like activity.
Red blood cell lysis photosensitized by Ketoprofen, 2-(3-benzoxyphenyl)propionic acid (KPF), was investigated in the presence of some copper(II) complexes with linear and cyclic dipeptides as well as functionalized beta-cyclodextrins with SOD-like activity with the aim of ascertaining their protective activity towards the photoinduced cell damage. The comparison between the decrease of photolytic activity caused by these complexes and their superoxide dismutase activity showed an appreciable correlation. The correct determination of species existing in experimental conditions was obtained through a simulation approach based on the knowledge of the stability constants of the complexes.
Dipartimento di Scienze Chimiche, Università di Catania, Italy.
G
G
Condorelli
L L
LL
Costanzo
G
G
De Guidi
S
S
Giuffrida
E
E
Rizzarelli
G
G
Vecchio
D000595:Amino Acid Sequence; D003300:Copper / Q000494:pharmacology*; D006461:Hemolysis; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D017665:Hydroxyl Radical / Q000097:blood; D007660:Ketoprofen; D008027:Light; D008969:Molecular Sequence Data; D010782:Photolysis; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013481:Superoxides / Q000097:blood
D013481:Superoxides; D017665:Hydroxyl Radical; D003300:Copper; D007660:Ketoprofen; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase