[The antibacterial effects of homologous interferons in an experimental staphylococcal infection].
Homologous interferons (IF) of the 1st and 2nd types are studied for their effect on the course of experimental staphylococcal infection. A model of intracutaneous infection of animals is used. Survival of mice, dynamics of the agent elimination from the organism, functional activity of phagocytes in dynamics of the infectious process during IF administration are studied. Only preparations of natural IF are found to possess a protective effect. The recombinant gamma-IF does not prevents from the mouse death and exerts no effect on the dynamics of elimination of agents from the organism.
Fil'chakov
I V
IV
Fil'chakov
F V
FV
Ivanenko
V K
VK
Blagodatnyĭ
V N
VN
Blizniuk
I A
IA
D000818:Animals; D004353:Drug Evaluation, Preclinical; D016898:Interferon-alpha / Q000008:administration & dosage*; D007371:Interferon-gamma / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D011994:Recombinant Proteins; D013203:Staphylococcal Infections / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D013997:Time Factors
D016898:Interferon-alpha; D011994:Recombinant Proteins; D007371:Interferon-gamma
Antibakterial'nye éffekty gomologichnykh interferonov pri éksperimental'noĭ stafilokokkovoĭ infektsii.