The effect of prostaglandins E2 and F2a on brain and tracheal ciliary activity.
Prostaglandins E2 and F2a have a mild stimulatory effect (+11% to 18% from baseline) on the in vitro ciliary beat frequency in tracheal rings, which contain mucus-producing cells, and in brain slices, which are devoid of mucus. Results are compared with previous studies and the merits of the used experimental models are discussed.
Roth
Y
Y
Department of Otorhinolaryngology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Kronenberg
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D006224:Cricetinae; D015237:Dinoprost / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009079:Mucociliary Clearance / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D015237:Dinoprost; D015232:Dinoprostone