The gene for the amyloid precursor-like protein APLP2 is assigned to human chromosome 11q23-q25.
The human amyloid precursor-like protein APLP2 is a highly conserved homologue of a sequence-specific DNA-binding mouse protein with a predicted function in the cell cycle. Somatic cell hybrids segregating human chromosomes were used to assign the APLP2 gene to chromosome 11. Fluorescence in situ hybridization confirmed this assignment and further localized the gene to q23-q25.
Max-Planck-Institut für Biophysikalische Chemie, Abt. Molekulare Biologie, Göttingen, Germany.
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von der Kammer
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Löffler
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Hanes
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Klaudiny
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Scheit
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Hansmann
D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D017124:Conserved Sequence; D004247:DNA; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*
C489697:APLP1 protein, human; C084104:APLP2 protein, human; D016564:Amyloid beta-Protein Precursor; C492952:Aplp2 protein, mouse; D009419:Nerve Tissue Proteins; D004247:DNA