High-dose recombinant human erythropoietin and low-dose corticosteroids for treatment of anemia in paroxysmal nocturnal hemoglobinuria.
Three patients with paroxysmal nocturnal hemoglobinuria (PNH) and severe anemia were treated with high-dose recombinant human erythropoietin (rHEpo) and low-dose corticosteroids. During therapy their hemoglobin levels gradually improved and no blood transfusions were required. Neither rHEpo nor corticosteroids caused any side effects. This study shows that high rHEpo and low corticosteroid doses may improve the anemia of PNH patients.
Department of Internal Medicine, Medical School, University of Ioannina, Greece.
K
K
Bourantas
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage; D012074:Remission Induction
D011994:Recombinant Proteins; D004921:Erythropoietin; D011239:Prednisolone