A multiple decision procedure in clinical trials.
In some multiple treatment arm clinical trials there is an order of preference for the treatments based on secondary considerations like toxicity or cost. In this paper, we consider the case where two or more treatments could have equal prior preference. This formulation includes the problem of comparing several equally preferred experimental treatments to one control, or the comparison of a combination with its components. Our decision procedures will guarantee a high selection probability for the correct treatment(s) when that selection is appropriate. We establish sample size requirements for our decision procedures which can be applied to clinical trials with normal, binomial, or right censored exponential endpoints.
Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892.
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D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data*; D003661:Decision Support Techniques; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy; D006801:Humans; D015233:Models, Statistical; D011336:Probability; D011882:Radiotherapy, High-Energy / Q000706:statistics & numerical data; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000706:statistics & numerical data*; D015996:Survival Rate