Biological activity of some coumarins from Sri Lankan Rutaceae.
Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay employing DNA repair-deficient and repair-proficient yeasts. Of these, seselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.
Gunatilaka
A A
AA
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Kingston
D G
DG
Wijeratne
E M
EM
Bandara
B M
BM
Hofmann
G A
GA
Johnson
R K
RK
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D000882:Haplorhini; D010946:Plants, Medicinal / Q000737:chemistry*; D013188:Sri Lanka; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins