Experience with pulse-spray technique in peripheral thrombolysis.
Pulse-spray thrombolysis (PST) is a new technique of accelerated peripheral arterial thrombolysis. This technique has been evaluated on 24 patients with limb ischaemia. Severe acute limb-threatening ischaemia with sensory and motor deficit was present in 11/24 (45.8%) patients. The median dose of recombinant tissue plasminogen activator (rt-PA) used was 18 mg (10-35 mg) injected in a concentration of 0.33 mg/ml and bolus size of 0.2 ml. The median length of occlusions treated was 23 cm (range 4-55 cm). Complete initial lysis was achieved in 23/24 (95.8%) and limb salvage at 30 days was achieved in 18/24 (75%) of the cases. The overall 30-days mortality was 4/24 (16.6%) and 2/4 (50%) in those who required surgical intervention. The median duration of thrombolytic treatment was 137.5 minutes (range 35-1125 minutes) which is an 11-fold and significant reduction (p < 0.001, Mann-Whitney) in lysis time compared with the results of conventional low dose infusion of rt-PA at a rate of 0.5 mg/h in 120 consecutive patients in our unit. PST rapidly restores vascular patency and may become the treatment of choice for acute limb ischaemia including those at immediate risk of irreversible ischaemic injury which would not be considered suitable for conventional thrombolysis.
Yusuf
S W
SW
Department of Vascular Surgery, University Hospital Nottingham, U.K.
Whitaker
S C
SC
Gregson
R H
RH
Wenham
P W
PW
Hopkinson
B R
BR
Makin
G S
GS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D015901:Angiography, Digital Subtraction; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage; D014654:Vascular Patency
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator