[Trichomonacidal activity of newly synthesized derivatives of benzoizothiazolinon (BIT) in vitro].
Trichomonacidal activity in vitro of 2 newly synthesized derivatives of benzoizothiazolinon (BIT) in comparison with metronidazole was determined by calculating lethal concentration for 50% trichomonal population (C50). Experiments were carried out on 2 strains of T. vaginalis and 2 strains of T. anseris. Both preparations showed considerably higher trichomonacidal activity than metronidazole. Mean values of trichomonacidal activity of N-morpholinomethyl-1,2-benzoizothiazolinon-3 for T. vaginalis and T. anseris amounted to 885 and 1997 respectively, and were 6 and 8 times higher than those of hydrochloride of N-piperydynomethyloamide of (5-chloro-1,2-benzoizothiazolinon-3ylo-2)-acetic acid. The lowest trichomonacidal activity of hydrochloride of N-piperydynomethylamide of (5-chloro-1,2-benzoizotiazolinon-3ylo-2)-acetic acid was 10-fold higher than that of N-morpholinomethyl-1,2-benzoizothiazolinon-3 and several hundred times lower than metronidazole concentration.
Ziomko
I
I
Zakład Parazytologii i Chorób Inwazyjnych Instytutu Weterynarii, Puławy.
Kuczyńska
E
E
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000994:Antitrichomonal Agents / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008795:Metronidazole / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D013045:Species Specificity; D013844:Thiazoles / Q000494:pharmacology*; D014244:Trichomonas / Q000187:drug effects*; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000081:Acetamides; D000994:Antitrichomonal Agents; C088040:N-morpholinomethyl-1,2-benzoisothiazolin-3-one; C088041:N-piperidinylmethyl-5-chloro-1,2-benzisothiazolin-3-one-2-acetamide; D010880:Piperidines; D013844:Thiazoles; D008795:Metronidazole
Aktywność rzesistkobójcza nowo zsyntetyzowanych pochodnych benzoizotiazolinonu (BIT) in vitro.