Attainment of normal height in severe juvenile hypothyroidism.
Prolonged juvenile hypothyroidism results in a permanent loss in height that is related to the duration of thyroxine deficiency before adequate thyroxine replacement treatment. A 13 year old girl with severe juvenile hypothyroidism was studied prospectively. She had an undetectable serum thyroxine concentration, a height SD score of -6.6 SD, and a bone age of 5.8 years. The enlarged pituitary gland involuted with thyroxine treatment to produce an empty sella. In addition to thyroxine the girl was treated with a gonadotrophin releasing hormone agonist to avoid the progression of puberty for 18 months and with growth hormone to achieve normal adult height.
Minamitani
K
K
Department of Paediatrics, Chiba University School of Medicine, Japan.
Murata
A
A
Ohnishi
H
H
Wataki
K
K
Yasuda
T
T
Niimi
H
H
D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006130:Growth Disorders / Q000517:prevention & control*; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D011446:Prospective Studies; D013974:Thyroxine / Q000627:therapeutic use
D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone; D013974:Thyroxine