Negative bone scintigraphy with diffuse osteoblastic breast carcinoma metastases.
A patient with diffuse osteoblastic metastases from invasive lobular carcinoma of the breast is presented in whom radionuclide bone scan was negative for skeletal lesions. Skeletal metastases were documented by plain radiography, CT, MRI, and bone marrow biopsy. This case report points to the value of plain-film, CT, and MRI findings in situations of high clinical suspicion of metastatic disease despite a normal scintigraphy.
Department of Radiology, University of California Davis School of Medicine, Sacramento.
B
B
Brown
A
A
Laorr
A
A
Greenspan
R
R
Stadalnik
D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000556:secondary*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed
D013669:Technetium Tc 99m Medronate