[Evaluation of the chronic antihypertensive effect of nitrendipine using ambulatory monitoring].
Twenty patients (12 males, 8 females, mean age 51 +/- 10 years) with mild to moderate arterial hypertension were treated with nitrendipine (mean daily dose 17 mg) during a 6 month period. Patients were evaluated with blood measurement and with 24-hour ambulatory blood pressure monitoring. In 16 patients who completed the study, systolic and diastolic blood pressure decreased of 13-15% and 18-20% respectively after at least 1 month of therapy. Mean 24-hour blood pressure was reduced of 9.7% (p < 0.01) at the end of the third month and of 13.9% (p < 0.01) at the end of the sixth month. Both systolic and diastolic 24-hour blood pressure were significantly reduced. Nitrendipine was active on day time and night time pressure. Only 1 patient had edema of the legs. Heart rate was not increased by the drug. Total cholesterol and LDL cholesterol were reduced.
Cattedra e Divisione Clinicizzata di Cardiologia, Università degli Studi, Verona.
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L
Rossi
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Tomei
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E
Carbonieri
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L
Franceschini
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P
Zardini
D000328:Adult; D015924:Blood Pressure Monitors; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000008:administration & dosage / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol; D009568:Nitrendipine
Valutazione seriata con monitoraggio ambulatoriale dell'effetto antipertensivo cronico della nitrendipina.