Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis).
Chromosome investigation in six localized forms of tenosynovial giant cell tumors, also known as modular tenosynovitis, revealed an identical translocation between chromosomes 1 and 2, t(1;2)(p11;q35-36) in three tumors, a variant translocation t(1;5)(p11;q22) in a fourth case, and a t(2;16)(q33;q24) in a fifth case. One case showed a normal karyotype. Although morphologically rather uniform, these benign tumors appear to be cytogenetically heterogeneous, but the chromosome changes seem to cluster in 2 regions, 1p11 and 16q24.
Center for Human Genetics, University of Leuven, Belgium.
P
P
Dal Cin
R
R
Sciot
I
I
Samson
L
L
De Smet
I
I
De Wever
B
B
Van Damme
H
H
Van den Berghe
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005870:Giant Cell Tumors / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane; D014178:Translocation, Genetic / Q000235:genetics*