Reduction by Hoe 140, the B2 kinin receptor antagonist, of antigen-induced nasal blockage.
In subjects with allergic rhinitis to house-dust mite (HDM), antigen challenge produced a significant increase in nasal blockage but had no effect on nasal vascular permeability. The B2 kinin receptor antagonist, [D-Arg0,Hyp3,Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140), 200 micrograms administered by intranasal aerosol 2 min prior to challenge with HDM, 500 u significantly reduced nasal blockage induced by the antigen challenge. The data are compatible with a role for B2 kinin receptors in the nasal response to challenge with antigen which is responsible for nasal blockage.
Department of Pharmacology, University College London.
C E
CE
Austin
J C
JC
Foreman
G K
GK
Scadding
D000328:Adult; D000368:Aged; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000941:Antigens / Q000276:immunology*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D065168:Bradykinin Receptor Antagonists; D002199:Capillary Permeability; D004391:Dust; D006801:Humans; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D009666:Nose / Q000503:physiopathology*; D018002:Receptors, Bradykinin / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000941:Antigens; D065168:Bradykinin Receptor Antagonists; D004391:Dust; D018002:Receptors, Bradykinin; C065679:icatibant; D001920:Bradykinin