Cooccurrence of collagenous colitis with seronegative spondyloarthropathy: report of a case and literature review.
Collagenous colitis is an uncommon cause of chronic watery diarrhea, characterized by colonic deposition of collagen. Nonerosive, oligoarticular, peripheral arthritis has previously been noted in about 7% of patients with collagenous colitis. We describe a patient with collagenous colitis who concurrently developed erosive, seronegative spondyloarthropathy affecting peripheral and axial joints. Synovial histology was characterized by a conspicuous inflammatory infiltrate comprised of histiocytes, lymphocytes and plasma cells. Collagenous colitis is suggested to be a systemic autoimmune disorder, with extraintestinal features such as thyroiditis and arthritis.
Kingsmore
S F
SF
Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC 27710.
Kingsmore
D B
DB
Hall
B D
BD
Wilson
J A
JA
Gottfried
M R
MR
Allen
N B
NB
D003092:Colitis / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000097:blood* / Q000150:complications* / Q000276:immunology
D003094:Collagen