(S)-UH301, a silent 5-HT1A receptor antagonist, enhances plasma corticosterone levels in the rat.
The putative silent 5-HT1A receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT1A receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT1A-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.
Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands.
L
L
Groenink
J
J
van der Gugten
J
J
Mos
R A
RA
Maes
B
B
Olivier
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists
D001786:Blood Glucose; D012702:Serotonin Antagonists; C064282:UH 301; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003345:Corticosterone