Expanding horizons for receptors coupled to G proteins: diversity and disease.
The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand detection. These and other developments promise continued excitement in this field.
Cardiovascular Research Institute, University of California, San Francisco 94143-0524.
S R
SR
Coughlin
D017398:Alternative Splicing; D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008961:Models, Structural; D009154:Mutation; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins