Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.
The cell surface receptor for ecotropic host-range murine leukemia viruses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter system y+, which was previously characterized by transport assays. Mutational analysis indicates that transporter activity is not necessary for viral reception. Infection of cells with ecotropic retroviruses causes only a partial down-modulation of receptor expression on cell surfaces.
Department of Biochemistry, Oregon Health Sciences, University Portland.
M P
MP
Kavanaugh
H
H
Wang
C A
CA
Boyd
R A
RA
North
D
D
Kabat
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D004553:Electric Conductivity; D009052:Leukemia Virus, Murine / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009865:Oocytes; D011991:Receptors, Virus; D017386:Sequence Homology, Amino Acid; D012964:Sodium / Q000494:pharmacology; D014982:Xenopus laevis
D000596:Amino Acids; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011991:Receptors, Virus; C070506:ecotropic murine leukemia virus receptor; D012964:Sodium