WR-1065 as a chemoprotector in Adriamycin chemotherapy.
The protective effect of WR-1065 against the side effects of Adriamycin was studied in tumor bearing mice. It has been noticed that WR-1065 pretreatment improved the Adriamycin toxicities such as increased enzyme levels, pathological lesions in lung, liver and heart and increased rate of lipid peroxidation, without reducing its anticancer property.
Bhanumathi
P
P
Government Medical College, Trichur, Kerela, India.
Saleesh
E D
ED
Vasudevan
D M
DM
D000818:Animals; D004249:DNA Damage; D004317:Doxorubicin / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008624:Mercaptoethylamines / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C
D008624:Mercaptoethylamines; C020174:N-(2-mercaptoethyl)-1,3-diaminopropane; D004317:Doxorubicin