[Correlation between crystalline structure and biological properties of sodium cefazolin].
Antimicrobial activity and toxicity of four polymorphic forms of sodium cefazolin were studied in comparison to those of the initial cefazolin. The observed changes reflecting a broader antimicrobial spectrum and low toxicity of one of the forms as compared with those of the initial cefazolin could serve as a prerequisite to successful screening of more active crystalline forms of the antibiotic aimed at designing the drug with better therapeutic properties.
Op'lchenova
G G
GG
Ovcharova
G D
GD
D000818:Animals; D002437:Cefazolin / Q000737:chemistry* / Q000494:pharmacology*; D003461:Crystallography; D004353:Drug Evaluation, Preclinical; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D002437:Cefazolin
Zavisimost' mezhdu kristallicheskoĭ strukturoĭ i biologicheskimi svoĭstvami tsefazolina natriia.