The neurotropic activity of a structural analog of ACTH(5-7).
The tripeptide glutamyl-arginyl-proline (ERP) mimicking some structural features of the N-terminal fragment of adrenocorticotropic hormone, ACTH(5-7), has been synthesized. In contrast with ACTH fragments, ERP (0.015-0.15 mg/kg; intraperitoneal injection) hindered the formation of food-reinforced task in adult albino male rats. Besides, ERP caused a rapid inhibition of the previously formed conditioned task. Similar doses of ERP changed orientative-trying reaction and emotional behavior in rats in the 'open field' test. ERP at a dose of 0.15 mg/kg administered prior to the injection of 0.5 mg/kg ACTH(1-39) prevented increases in locomotor activity normally induced by this hormone. Thus, ERP disrupts learning, impairs performance of acquired task and blocks behavioral effects of ACTH and its fragments.
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow.
I P
IP
Ashmarin
N G
NG
Levitskaya
L V
LV
Antonova
V N
VN
Nezavibatko
Alfeeva LYu
V A
VA
Dubinin
V P
VP
Golubovich
M A
MA
Ponomareva-Stepnaya
A A
AA
Kamensky
D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D008969:Molecular Sequence Data; D009043:Motor Activity / Q000187:drug effects; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D009842:Oligopeptides; C088345:glutamyl-arginyl-proline; D000324:Adrenocorticotropic Hormone