[The antithrombogenic properties of the vascular wall and platelet aggregation in patients with atherosclerosis of the arteries of the lower extremities following a course of treatment with UV-irradiated autologous blood transfusion].
Sixteen patients with lower limb atherosclerosis (LLAS) stage II-III received autotransfusions of blood irradiated by ultraviolet light. Vascular wall antithrombogenic properties assessed before the treatment in the patients and controls were found deteriorated in LLAS subjects. The cuff test did not affect the antithrombogenic characteristics. The course of autotransfusions produced a clinical improvement and strengthening of the antithrombogenic properties. The cuff test demonstrated a significant decline in platelet aggregation in response to ADP, thrombin, collagen, ristomycin, arachidonic acid; of platelet factor 4, thromboxane B2, beta-thromboglobulin. Concentrations of antithrombin III, plasminogen, prostacyclin rose. The autotransfusions were made on "Izolda" device MD-73 (1 ml of blood per 1 kg b. mass). Irradiation dose 750 J/m2, wave length 254 nm. Platelet aggregation was studied according to Born technique in O'Brien modification. Thromboxane B2, 6-keto-PGF1 alpha, beta-thromboglobulin and TF 4 were measured by radioimmunoassay, antithrombin III and plasminogen by chromogenic substrates.
A S
AS
Adamchik
G N
GN
Sushkevich
A A
AA
Kubatiev
Iu V
IuV
Belov
D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000097:blood* / Q000628:therapy*; D001804:Blood Transfusion, Autologous / Q000295:instrumentation / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D012074:Remission Induction; D013927:Thrombosis / Q000517:prevention & control*; D014467:Ultraviolet Therapy / Q000295:instrumentation / Q000379:methods*
Antitrombogennye svoĭstva sosudistoĭ stenki i agregatsiia trombotsitov u bol'nykh aterosklerozom arteriĭ nizhnikh konechnosteĭ posle kursa lecheniia autotransfuzieĭ UF-obluchennoĭ krovi.