Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task.
We investigated the effects of nefiracetam (DM-9384), a pyrrolidone derivative, on chlordiazepoxide-, apomorphine-, and methamphetamine-induced impairment of latent learning in a water finding test in mice. Pretreatment with nefiracetam reversed the inhibitory effects of chlordiazepoxide and apomorphine, but not those of methamphetamine, on latent learning. The ameliorative effects of nefiracetam on apomorphine-induced, but not chlordiazepoxide-induced impairment of latent learning were antagonized by scopolamine. These results provide further evidence that nefiracetam has anti-amnesic effects. Further, it is suggested that the cholinergic neuronal system may be involved in the ameliorative effects exerted by nefiracetam on apomorphine-induced impairment of latent learning.
Nabeshima
T
T
Department of Neuropsychopharmacology, Nagoya University School of Medicine, Japan.
Nakayama
S
S
Ichihara
K
K
Yamada
K
K
Shiotani
T
T
Hasegawa
T
T
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D002707:Chlordiazepoxide / Q000037:antagonists & inhibitors; D007859:Learning Disabilities / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors; D051379:Mice; D008815:Mice, Inbred Strains; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects*
D011619:Psychotropic Drugs; D011760:Pyrrolidinones; C058876:nefiracetam; D008694:Methamphetamine; D002707:Chlordiazepoxide; D001058:Apomorphine