Epstein-Barr virus: adaptation to a life within the immune system.
Epstein-Barr virus has developed multiple strategies to ensure its long-term persistence in the infected B cells of immunocompetent hosts. These include the establishment of cell-phenotype-specific programs of viral gene expression and the transduction of cellular genes that modulate immune responses. Cytotoxic T cells may specifically influence the evolution of this genetically stable virus.
Masucci
M G
MG
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
Ernberg
I
I
D000222:Adaptation, Physiological; D000818:Animals; D001402:B-Lymphocytes / Q000382:microbiology*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*