Chronic sensorimotor polyneuropathy associated with cerebello-extrapyramidal manifestations in a patient with tomaculous neuropathy.
Clinical, electrophysiological and morphological (sural nerve and gastrocnemius muscle biopsies) data of a 57-year-old man with a chronic sensorimotor polyneuropathy of Charcot-Marie-Tooth type associated with a progressive cerebello-extrapyramidal syndrome are reported. Patient's family data were negative. Nerve structural and ultrastructural examinations revealed the morphological picture of a tomaculous neuropathy. The association of different clinical syndromes and the specificity of the tomaculous neuropathy are discussed.
Macovei
M
M
Institute of Neurology and Psychiatry, Bucharest, Romania.
Alexianu
M
M
Vasilescu
C
C
Alexianu
M E
ME
Dan
A
A
Burghelea
B
B
D001480:Basal Ganglia Diseases / Q000175:diagnosis*; D001706:Biopsy; D002526:Cerebellar Diseases / Q000175:diagnosis*; D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis*; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000648:ultrastructure; D010243:Paralysis / Q000175:diagnosis*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis*; D012008:Recurrence; D013497:Sural Nerve / Q000648:ultrastructure