Another procedure for the preliminary ordering of loci based on two point lod scores.
Because of the difficulty of performing full likelihood analysis over multiple loci and the large numbers of possible orders, a number of methods have been proposed for quickly evaluating orders and, to a lesser extent, for generating good orders. A new method is proposed which uses a function which is moderately laborious to compute, the sum of lod scores between all pairs of loci. This function can be smoothly minimized by initially allowing the loci to be placed anywhere in space, and only subsequently constraining them to lie along a one-dimensional map. Application of this approach to sample data suggests that it has promise and might usefully be combined with other methods when loci need to be ordered.
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Academic Department of Psychiatry, St Mary's Hospital Medical School, London.
D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score