Necrosis in a meningioma following systemic chemotherapy. Case report.
Radiological and clinical evidence of acute necrosis in a meningioma following one cycle of chemotherapy with 5-fluorouracil, folinic acid, and levamisole was observed in a patient being treated for invasive rectal carcinoma. The possible mechanisms and implications of this occurrence are discussed.
Division of Neurosurgery, Toronto Hospital, Ontario, Canada.
M
M
Bernstein
A
A
Villamil
G
G
Davidson
C
C
Erlichman
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D007978:Levamisole / Q000008:administration & dosage; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D008579:Meningioma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D008875:Middle Aged; D009336:Necrosis; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy
D007978:Levamisole; D002955:Leucovorin; D005472:Fluorouracil