Anaemia, blood transfusion practices, HIV and mortality among women of reproductive age in western Kenya.
Severe anaemia among women in sub-Saharan Africa is frequently treated with blood transfusions. The risk of transmission of human immunodeficiency virus (HIV) through blood products has led to a re-evaluation of the indications for transfusions. Prospective surveillance of women admitted to a district hospital in western Kenya was conducted from 1 December 1990 to 31 July 1991, for haemoglobin (Hb) transfusion status, and outcome. Of the 2986 enrolled women (mean Hb 10.4 g/dL, SD +/- 2.6, median age 24.4 years), 6% were severely anaemic (Hb < 6.0 g/dL). Severe anaemia was associated with a higher mortality rate (10.7% vs. 1.4%, odds ratio (OR) = 8.2, 95% confidence interval (CI) 2.6, 34.2) compared with women with Hb > or = 6.0 g/dL. Decreased mortality rates in hospital were observed with increasing Hb values (OR = 0.43, 95% CI 0.19, 0.98), but blood transfusions did not improve survival in hospital (OR = 1.56, 95% CI 0.22, 11.03). The attributable mortality due to HIV infection and severe anaemia was 75% and 31%, respectively. Maternal/child health care services must include prevention strategies for HIV transmission and the prevention, recognition, and treatment of severe anaemia.
Zucker
J R
JR
Malaria Branch, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333.
Lackritz
E M
EM
Ruebush
T K
TK
Hightower
A W
AW
Adungosi
J E
JE
Were
J B
JB
Campbell
C C
CC
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000401:mortality* / Q000628:therapy; D001803:Blood Transfusion / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000401:mortality* / Q000635:transmission; D006454:Hemoglobins / Q000032:analysis; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D016015:Logistic Models; D015999:Multivariate Analysis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000401:mortality; D011446:Prospective Studies
D006454:Hemoglobins