[Efficacy of intravenous propafenone in the management of arterial flutter and fibrillation of recent onset].
We assessed the safety and efficacy of intravenous propafenone in the treatment of atrial fibrillation and flutter of recent onset (1-10 days). The drug was administered, at a dosage of 2 mg/kg, to 46 consecutive patients (with age variable from 35 to 86 years), 36 with atrial fibrillation, 10 with atrial flutter. The efficacy of propafenone was influenced by the interval from the onset of the arrhythmia and the start of therapy. All patients underwent echocardiographic control: mean left atrial dimensions were non significantly different in responders and non responders. Serious hypotension developed in two patients, regressed with appropriate therapy. Non responders showed a significant reduction of ventricular rate. By synthesis, propafenone is a safe and effective drug for treatment of atrial fibrillation or flutter of recent onset, in refractory patients it allows however an adequate control of ventricular rate.
Servizio di Cardiologia, Regione Marche, Unità Sanitaria Locale n. 20, Presidio Ospedaliero di Camerino.
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001282:Atrial Flutter / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004452:Echocardiography; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D011405:Propafenone
Efficacia del propafenone e.v. nel trattamento del flutter e della fibrillazione atriale di recente insorgenza.