Structure and expression of a novel rat RegIII gene.
We have isolated a rat cDNA and a novel gene, Reg (regeneration-promoting gene). The cDNA encodes a 174-amino-acid (aa) RegIII protein with a 25-aa signal peptide. The RegIII gene spans 2.7 kb and consists of six exons and five introns. RegIII was expressed in regenerating pancreatic islets, but not in normal islets.
Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan.
Y
Y
Suzuki
H
H
Yonekura
T
T
Watanabe
M
M
Unno
S
S
Moriizumi
H
H
Miyashita
H
H
Okamoto
D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm; D001483:Base Sequence; D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D005091:Exons; D007438:Introns; D007515:Islets of Langerhans / Q000378:metabolism* / Q000502:physiology; D037181:Lectins, C-Type; D008969:Molecular Sequence Data; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins / Q000235:genetics*; D051381:Rats; D012038:Regeneration / Q000235:genetics*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D037181:Lectins, C-Type; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins; C490253:Reg3b protein, mouse; C088549:RegIII protein, mouse