Synthesis and anticandidal activities of optimized analogs of antibiotic Sch 37137.
Peptide analogues of Sch 37137 the antifungal antibiotic have been synthesized and evaluated in vitro against Candida sp. Di- and tripeptides containing methionine, leucine, norvaline, lysine, glutamic acid and N3-(trans-epoxysuccinamoyl)-L-2,3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (D)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in general higher anticandidal activity than a mixture of diastereomers of Sch 37137.
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
R
R
Andruszkiewicz
T
T
Zieniawa
H
H
Chmara
L
L
Kasprzak
E
E
Borowski
D000599:Amino Acids, Diamino / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D000599:Amino Acids, Diamino; D000935:Antifungal Agents; C055110:N-L-alanyl-3-(((3-(aminocarbonyl)oxiranyl)carbonyl)amino)-L-alanine