Effect of antacids in didanosine tablet on bioavailability of isoniazid.
The antacids in two didanosine placebo tablets had no significant effect on the plasma pharmacokinetics of a single oral dose of 300 mg of isoniazid administered to 12 healthy volunteers. These results suggest that isoniazid bioavailability will be unaffected by the antacids in didanosine tablets when the two medications are administered simultaneously to human immunodeficiency virus-seropositive patients.
Bureau of Drug Research, Sir Frederick Banting Research Centre, Ottawa, Ontario, Canada.
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Gallicano
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Sahai
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Zaror-Behrens
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Pakuts
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D016049:Didanosine / Q000008:administration & dosage*; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000493:pharmacokinetics*; D008297:Male; D012044:Regression Analysis
D000863:Antacids; D004338:Drug Combinations; D016049:Didanosine; D007538:Isoniazid