[Factor VIII/Ag (von Willebrand) and protein C. Erythrocyte deformability and aggregability. The risk parameters of retinal vein occlusion].
In 32 patients with retinal vein occlusion we measured coagulative and hematic parameters. The coagulative factors were in the normal range, save C-Protein, that was decreased and the Von Willebrand Factor that appeared increased in a significant way. These changes do not affect the coagulation state, but, in a local vascular district, they can interfere with mechanisms of thromboresistance, over all in the retinal district owing to its peculiar structure and its flow of terminal kind. The hemorheologic alterations consist in a decrease in the erythrocyte deformability and in an increase in the plasma-erythrocyte and plasma viscosities, measured both with a rotational method and with a filtering one. We have not found any correlation between coagulative factors and hemorheologic parameters, nevertheless these last ones determine a lowering down of the local flow, that with the morphological changes in the vascular system, give rise to conditions for an occlusion event.
IRCCS Policlinico San Matteo di Pavia, Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.
A
A
Cortinovis
A
A
Crippa
M
M
Crippa
D000368:Aged; D000369:Aged, 80 and over; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis*; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D014841:von Willebrand Factor / Q000032:analysis*
D011486:Protein C; D014841:von Willebrand Factor
Fattore VIII/Ag (von Willebrand) e proteina C. Deformabilità e aggregabilità eritrocitaria. Parametri di rischio di occlusione venosa retinica.