Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis.
A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) ointment cured all Leishmania major lesions on Balb/C mice following topical application for 10 d. Some relapses were observed 10 weeks after treatment. AS alone in WSP ointment was also highly effective. The ointment containing urea was non-irritant to mice, whereas ointments containing quaternary ammonium compounds were irritant. The 15% AS/10% urea/WSP ointment was not effective in the treatment of L. mexicana or L. panamensis lesions on Balb/C mice, no cure being observed.
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
R A
RA
Neal
A G
AG
Murphy
P
P
Olliaro
S L
SL
Croft
D000818:Animals; D005260:Female; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009824:Ointments; D010303:Paromomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation
D009824:Ointments; D010303:Paromomycin