[Effect of alpha-tocopherol and ubiquinone on mitochondrial RNA polymerase activity. The role of tocopherol-binding proteins].
It has been shown that alpha-tocopherol within the complex with tocopherol-binding proteins, in contrast with free tocopherol, decreases the RNA-polymerase activity in isolated rat liver mitochondria. Both free and complexed to proteins alpha-tocopherol increases the RNA-polymerase activity in isolated nuclei. The effect of alpha-tocopherol is conditioned mostly by the nature of the tocopherol-binding proteins. It has been established that ubiquinone complexed to tocopherol-binding proteins from mitochondria can also change the level of RNA synthesis. The effect of alpha-tocopherol and ubiquinone are not additive.
Petrova
G V
GV
Kapralov
A A
AA
Izhokina
I A
IA
Donchenko
G V
GV
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D051381:Rats; D014451:Ubiquinone / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D002352:Carrier Proteins; C017763:alpha-tocopherol transfer protein; D014451:Ubiquinone; D014810:Vitamin E; D012321:DNA-Directed RNA Polymerases
Vliianie alpha-tokoferola i ubikhinona na RNK-polimeraznuiu aktivnost' mitokhondriĭ. Rol' tokoferolsviazyvaiushchikh belkov.