[Congenital factor V deficiency and intraventricular hemorrhage of prenatal origin].
The Authors describe a case of congenital coagulation factor V deficiency with severe prenatal intraventricular hemorrhage. Factor V is an essential enzyme catalysing the process of thrombin generation. Low levels of enzyme were also found in both parents, who demonstrate subclinic alterations of coagulation parameters. The severe deficiency of factor V in the newborn (8%) caused frequent and severe intracranial and gastric hemorrhages that brought newborn to death in few weeks.
Divisione di Pediatria, Ospedale Città di Sesto S. Giovanni (MI), Italia.
G
G
Bonvini
A
A
Cotta-Ramusino
G
G
Ricciardi
D001780:Blood Coagulation Tests; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005166:Factor V Deficiency / Q000150:complications / Q000175:diagnosis; D005315:Fetal Diseases; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006408:Hematoma, Subdural / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male
Deficit congenito di fattore V ed emorragia intraventricolare di origine prenatale.