Hypersensitivity to molybdenum as a possible trigger of ANA-negative systemic lupus erythematosus.
After implantation of two metal plates a 24 year old woman developed fever of unknown origin and successively more symptoms of an ANA-negative systemic lupus erythematosus (SLE). These symptoms resolved after removal of the plates and recurred during patch testing of the metal components, which showed a reaction to molybdenum. A lymphocyte transformation test indicated a delayed-type hypersensitivity to molybdenum. Subsequent progressive flare ups of SLE appeared without molybdenum reexposure. This is the first report suggesting the existence of a hypersensitivity to molybdenum, which may act as another environmental trigger for SLE.
Medizinische Abteilung, Spital Schweizerische Pflegerinnenschule, Zürich, Switzerland.
M
M
Federmann
B
B
Morell
G
G
Graetz
M
M
Wyss
P
P
Elsner
R
R
von Thiessen
B
B
Wüthrich
D
D
Grob
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D004342:Drug Hypersensitivity / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D008213:Lymphocyte Activation; D008982:Molybdenum / Q000009:adverse effects* / Q000276:immunology
D000974:Antibodies, Antinuclear; D008982:Molybdenum