Nervous tissue as an immune compartment: the dialect of the immune response in the CNS.
Here, Zsuzsa Fabry and colleagues address the question of whether the unique cellular environment of the central nervous system (CNS) contributes to the observed differences in immunological functions between the CNS and other organs. In particular, they discuss the significance within the CNS of the blood-brain barrier, the nonconstitutive expression of major histocompatibility complex (MHC) molecules, the unusual set of potential antigen-presenting and effector cells, and the production of immune or neuromediators from various cellular sources.
University of Iowa College of Medicine, Dept of Pathology, Iowa City 52242.
Z
Z
Fabry
C S
CS
Raine
M N
MN
Hart
D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology; D002490:Central Nervous System / Q000166:cytology / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology
D015815:Cell Adhesion Molecules; D016207:Cytokines