The association of ageing with calcium active hormone status in men.
We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p < 0.01) together with a parallel increase in urinary (r = 0.46, p < 0.05) and nephrogenic cAMP (r = 0.63, p < 0.01), while BMD decreases with age (r = -0.52, p < 0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.
Ravaglia
G
G
Cattedra di Medicina Interna II, Università di Bologna, Italy.
Forti
P
P
Pratelli
L
L
Maioli
F
F
Scali
C R
CR
Bonini
A M
AM
Tedioli
S
S
Marasti
N
N
Pizzoferrato
A
A
Gasbarrini
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000097:blood*; D000242:Cyclic AMP / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012016:Reference Values; D013963:Thyroid Hormones / Q000097:blood
D010281:Parathyroid Hormone; D013963:Thyroid Hormones; D000242:Cyclic AMP; D002117:Calcitriol; D002118:Calcium; D006854:Hydrocortisone