Osteomesopyknosis: report of a new case with bone histology.
A new case of osteomesopyknosis, a rare autosomal dominant axial osteosclerosis is reported, with 4 affected members of the same family. Biochemical investigations, bone mineral content (BMC) measurement, 99mTc HMDP bone scan and microscopy of iliac crest bone and femoral head have been performed on 1 subject. A marked increase of BMC was found, without abnormality of biochemical data. Microscopy of bone showed an increase of trabecular thickness, and a low rate of bone turnover. No abnormality of mineralization was found on microradiographs.
Institut de Recherche sur les Maladies du Squèlette, Institut Calot, Berck sur Mer, France.
P
P
Hardouin
B
B
Flautre
B
B
Sutter
H
H
Leclet
B
B
Grardel
P
P
Fauquert
D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D010026:Osteosclerosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D010375:Pedigree; D011859:Radiography