A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus.
Mutations at the nude locus disrupt the homing process of T cell progenitor cells to the thymic rudiment, a key aspect of T cell differentiation. Here, we map the nude locus to a set of overlapping yeast artificial chromosomes (YAC) clones covering a genetic interval of about 0.5 centi Morgan on mouse chromosome 11. These results provide a suitable starting point to molecularly clone the nude gene.
Nehls
M
M
Department of Medicine I, University of Freiburg, Germany.
Lüno
K
K
Schorpp
M
M
Krause
S
S
Matysiak-Scholze
U
U
Prokop
C M
CM
Hedrich
H J
HJ
Boehm
T
T
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping / Q000662:veterinary*; D018244:Chromosomes, Artificial, Yeast; D003433:Crosses, Genetic; D005819:Genetic Markers; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude / Q000235:genetics*; D008969:Molecular Sequence Data
D005819:Genetic Markers