[Transformation of hepatic adenoma into hepatocellular carcinoma in patients with prolonged use of oral contraceptives].
Liver cell adenomas were relatively rare until the use of oral contraceptives. Most of these tumors have occurred in otherwise healthy young women who have been exposed to oral contraceptives. The treatment of this condition remained controversial for a long time. However, bleeding is still a frequent complication and can lead to a significant mortality rate. The better surgical results in hepatic resection, due to technological advances, has contributed to the indication of surgical management as therapeutic option in hepatic cell adenoma. Some authors believe that liver cell adenomas were potentially premalignant and could degenerate into hepatocellular carcinoma but there is very few well documented reports of this transformation. We report our experience in the management of liver cell adenoma.
Herman
P
P
Departamento de Gastroenterologia da Faculdade de Medicina da Universidade de São Paulo.
Machado
M A
MA
Volpe
P
P
Pugliese
V
V
Vianna
M R
MR
Bacchella
T
T
Machado
M C
MC
Pinotti
H W
HW
D018248:Adenoma, Liver Cell / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
D003276:Contraceptives, Oral
Transformação de adenoma hepático em carcinoma hepatocelular em pacientes com uso prolongado de contraceptivo oral.