Production of aromatic alpha-hydroxyacids by epimastigotes of Trypanosoma cruzi, and its possible role in NADH reoxidation.
Epimastigotes of Trypanosoma cruzi in culture produce and excrete into the medium small amounts of phenyllactic acid and p-hydroxyphenyllactic acids, presumably arising from the catabolism of the aromatic amino acids phenylalanine and tyrosine, respectively. This production might constitute a minor pathway for the reoxidation of cytosolic NADH, through the concerted action of tyrosine aminotransferase and aromatic alpha-hydroxyacid dehydrogenase.
IQUIFIB (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
M
M
Montemartini
J A
JA
Santomé
J J
JJ
Cazzulo
C
C
Nowicki
D000818:Animals; D006880:Hydroxy Acids / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D008954:Models, Biological; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D010666:Phenylpropionates / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000254:growth & development / Q000378:metabolism*
D006880:Hydroxy Acids; D007211:Indoles; D007773:Lactates; D010666:Phenylpropionates; D009243:NAD; C001418:4-hydroxyphenyllactic acid; C024139:indole-3-lactic acid; D010088:Oxidoreductases