Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies.
We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic beta-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.
O'Brien
T D
TD
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
Rizza
R A
RA
Carney
J A
JA
Butler
P C
PC
D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D007333:Insulin Resistance / Q000276:immunology*; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D011972:Receptor, Insulin / Q000276:immunology*; D014452:Ubiquitins / Q000032:analysis
D000682:Amyloid; D001323:Autoantibodies; D058228:Islet Amyloid Polypeptide; D014452:Ubiquitins; D011972:Receptor, Insulin