The role of brain-immune interactions in immunotoxicology.
Certain xenobiotics (or the metabolites) can damage immunocompetence by directly interacting with one or more of the cells of the immune system and adversely affecting its function. It has also been proposed that xenobiotics may indirectly affect immune function by affecting other organ systems that will in turn affect immunocompetence. This review surveys evidence that supports the existence of a functional link between the brain and the immune system. In addition, we review data that support the concept that a xenobiotic-induced dysfunction in the neuroendocrine system may be associated with an immune dysfunction as well. Such chemicals do not necessarily interact directly with immunocompetent cells but would instead act to disrupt regulatory brain-immune interactions. This class of indirectly acting immunotoxic xenobiotics would not be detected in the typical in vitro screening assays.
Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond 23298-0613.
B A
BA
Fuchs
V M
VM
Sanders
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000276:immunology*; D003346:Corticotropin-Releasing Hormone / Q000276:immunology / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007121:Immunocompetence / Q000187:drug effects; D008285:Major Histocompatibility Complex / Q000276:immunology / Q000502:physiology; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000276:immunology; D010913:Pituitary-Adrenal System / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000276:immunology*; D015262:Xenobiotics / Q000378:metabolism / Q000633:toxicity*
D016207:Cytokines; D015262:Xenobiotics; D003346:Corticotropin-Releasing Hormone