[Histopathologic lesions of the accessory salivary glands in Gougerot-Sjögren syndrome: re-evaluation of the diagnostic criteria of Chisholm and Mason and of Chometter et al].
In a retrospective study, we used a series of 29 patients with Sjögren's Syndrome diagnosed according to the new European criteria (Cl. Vitali, S. Bombardieri, H. M. Moutsopoulos et al.) (8). (Arthritis Rheum 1993; 36:340-7). A labial biopsy technique allowed to classify these patients into the anatomical "scores" formerly related by Chisholm and Mason and Chomette et al. Referring to these criteria, only 45% of patients presented a characteristic histopathological pattern. If another complementary criterium, i.e. ductal tropism of lymphoid infiltrates, was added, that percentage remained low (50% only). Thus, these results would suggest the following considerations: the classical histopathological criteria do not seem sufficiently specific; other histological criteria such as ductal lesions previously noted by Leroy et al. must in addition be looked for; thus it would seem to be of considerable value to use in the future complementary quantitative studies by means of morphometric methods.
Service Central d'Anatomie et Cytologie pathologiques, Groupe Hospitalier Pitie-Salpêtrière, Paris.
Y
Y
Le Charpentier
M
M
Auriol
T H
TH
Boutin
G
G
Le Naour
F
F
Charlotte
S
S
Agbo-Godeau
H
H
Szpirglas
P
P
Godeau
F
F
Guilbert
D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005089:Exocytosis; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012470:Salivary Glands, Minor / Q000473:pathology*; D012598:Sclerosis; D012859:Sjogren's Syndrome / Q000145:classification / Q000175:diagnosis* / Q000473:pathology
Lésions histopathologiques des glandes salivaires accessoires (G.S.A.) au cours du syndrome de Gougerot-Sjögren: réévaluation des critères diagnostiques de Chisholm et Mason et de Chomette et coll.