Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination.
The structure of cytostatin was determined to be 5,6-dihydro-5-methyl-6-(6-hydroxy,1,5-dimethyl-4-phosphonooxy-7,9, 11-tridecatrienyl)-2H-pyran-2-one sodium salt on the basis of physico-chemical properties and NMR studies.
Institute for Chemotherapy, M.C.R.F. Shizuoka, Japan.
M
M
Amemiya
T
T
Someno
R
R
Sawa
H
H
Naganawa
M
M
Ishizuka
T
T
Takeuchi
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010755:Organophosphates / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D016326:Extracellular Matrix Proteins; D010755:Organophosphates; D011753:Pyrones; C088526:cytostatin