Role of subgenomic minus-strand RNA in coronavirus replication.
Coronavirus subgenomic minus-strand RNAs (negative-strand copies of the 3' coterminal subgenomic mRNAs) probably function in mRNA amplification by serving as templates for transcription from internal (intergenic) promoters, rather than by faithful (full-length) mRNA replication.
Brian
D A
DA
Department of Microbiology, University of Tennessee, Knoxville.
Chang
R Y
RY
Hofmann
M A
MA
Sethna
P B
PB
D001483:Base Sequence; D002478:Cells, Cultured; D017938:Coronavirus, Bovine / Q000235:genetics / Q000254:growth & development*; D003673:Defective Viruses / Q000235:genetics; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D014158:Transcription, Genetic; D014779:Virus Replication / Q000235:genetics
D012333:RNA, Messenger; D012367:RNA, Viral