Tyrosinase inhibitors from Anacardium occidentale fruits.
Anacardic acids, 2-methylcardols, and cardols isolated from various parts of the cashew [Anacardium occidentale] (Anacardiaceae) fruit have been found to exhibit tyrosinase inhibitory activity. Kinetic studies with the two principal active compounds, 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid and 5-[8(Z),11(Z),14-pentadecatrienyl]resorcinol, have indicated that both of these phenolic compounds exhibit characteristic competitive inhibition of the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase.
Kubo
I
I
Department of Environmental Science, Policy and Management, University of California, Berkeley 94720.
Kinst-Hori
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I
Yokokawa
Y
Y
D048729:Anacardic Acids; D001487:Basidiomycota / Q000201:enzymology; D007700:Kinetics; D007980:Levodopa / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009754:Nuts / Q000737:chemistry*; D010084:Oxidation-Reduction; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology; D012459:Salicylates / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D048729:Anacardic Acids; D012118:Resorcinols; D012459:Salicylates; C088114:5-(8,11,14-pentadecatrienyl)resorcinol; C088115:anacardic acid; D007980:Levodopa; D014442:Monophenol Monooxygenase