Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat.
Repeated treatment with dl-pentazocine (5-10 mg/kg i.p.), but not d-methamphetamine (4.8 mg/kg i.p.), twice daily for 8 days diminished the specific [3H]1,3-di-o-tolylguanidine (DTG) binding to the haloperidol-sensitive sigma sites in rat striatum and hippocampus. Either drug failed to cause any changes in the binding to the hypothalamus and prefrontal cortex. The pentazocine-induced diminution in the striatum was accompanied by a decrease in the density with an increase in the affinity of the [3H]DTG binding. These data suggest that repetitive use of dl-pentazocine may influence the regulation systems of the sigma site in specific brain regions.
Division of Mental Disorder Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Y
Y
Shirayama
T
T
Nishikawa
K
K
Takahashi
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D010423:Pentazocine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000187:drug effects / Q000378:metabolism*; D013237:Stereoisomerism
D000927:Anticonvulsants; D006146:Guanidines; D017480:Receptors, sigma; D008694:Methamphetamine; D006220:Haloperidol; C050232:1,3-ditolylguanidine; D010423:Pentazocine; D003913:Dextroamphetamine