[Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia].
Serum selenium concentration (scSe) (microgram/l) was comparatively measured in healthy persons (n = 202), patients with colorectal adenoma(s) (n = 44) and colorectal carcinoma (n = 48). In patients with adenoma(s) scSe (59.05 +/- 15) was significantly lower (p < 0.001) compared with scSe in the control group (66.8 +/- 14.43). Hyposelenemia was more pronounced in patients with multiple polyps (n = 11) than in patients with single adenoma (n = 33) (p < 0.05). Patients with colorectal carcinoma had also significant decrease in scSe (50.93 +/- 13.81) compared with the control group (p < 0.001 and with the adenoma patients (p < 0.001). According to the analysis of variance, highly significant differences were found among the cancer patients stratified in Dukes' stages A to D (p < 0.001), indicating a strong negative correlation between extension of cancer and hyposelenemia. Furthermore, hyposelenemia seemed to be more pronounced in the mucinous type of carcinoma than in adenocarcinoma (p = 0.056). This results indicate that hyposelenemia is strongly associated with colorectal neoplasia (including extension and severity of the disease) and that it may not only be a result but also one of tumorogenic factors. That means that selenium supplementation could be important in prevention or even adjuvant therapy of colorectal cancer.
Vucelic
B
B
Gastroenterologischen Abteilung der Inneren Klinik, Universitätsklinik, Rebro, Zagreb, Kroatien.
Buljevac
M
M
Romic
Z
Z
Milicic
D
D
Ostojic
R
R
Krznaric
Z
Z
D011125:Adenomatous Polyposis Coli / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D017523:Croatia; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012016:Reference Values; D012307:Risk Factors; D012643:Selenium / Q000097:blood*
D012643:Selenium
Unterschiede in den Selenkonzentrationen im Serum bei Gesunden und bei Patienten mit kolorektaler Neoplasie in Zagreb, Kroatien.