Structure and expression of a novel rat RegIII gene.
We have isolated a rat cDNA and a novel gene, Reg (regeneration-promoting gene). The cDNA encodes a 174-amino-acid (aa) RegIII protein with a 25-aa signal peptide. The RegIII gene spans 2.7 kb and consists of six exons and five introns. RegIII was expressed in regenerating pancreatic islets, but not in normal islets.
Suzuki
Y
Y
Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan.
Yonekura
H
H
Watanabe
T
T
Unno
M
M
Moriizumi
S
S
Miyashita
H
H
Okamoto
H
H
D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm; D001483:Base Sequence; D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D005091:Exons; D007438:Introns; D007515:Islets of Langerhans / Q000378:metabolism* / Q000502:physiology; D037181:Lectins, C-Type; D008969:Molecular Sequence Data; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins / Q000235:genetics*; D051381:Rats; D012038:Regeneration / Q000235:genetics*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D037181:Lectins, C-Type; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins; C490253:Reg3b protein, mouse; C088549:RegIII protein, mouse