Intraductal tetracycline therapy for the treatment of chronic recurrent parotitis.
Chronic recurrent parotitis (CRP) is recurrent parotid inflammation with non-obstructive sialectasis. Therapies which produce acinar atrophy or remove the acini are effective in treating CRP. Parotidectomy, tympanic neurectomy, duct ligation, and radiation therapy have either a low success rate or a high risk of morbidity. Intraductal antibiotic instillation has been proposed as a possible method of treatment. We hypothesized that the cytotoxic effects of tetracycline could produce acinar atrophy. A double-blind experiment of intraductal tetracycline instillation was performed in ten rabbits. Acinar atrophy and acute inflammation were found in 40% of the tetracycline treated glands; controls had a complete absence of these histologic changes. These results support the use of tetracycline instillation to produce acinar atrophy and therefore, intraductal tetracycline may be an effective, low-risk therapy for CRP. The clinical features of CRP will be reviewed and therapeutic implications discussed.
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
D M
DM
Bowling
G
G
Ferry
S D
SD
Rauch
M L
ML
Goodman
D000328:Adult; D000818:Animals; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010309:Parotitis / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D010784:Photomicrography; D011817:Rabbits; D012008:Recurrence; D012469:Salivary Glands / Q000528:radiation effects / Q000648:ultrastructure; D012796:Sialography; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*
D013752:Tetracycline