Effect of arginine on cisplatin-induced acute renal failure in the rat.
The effect of arginine on the nephrotoxicity produced by cisplatin (6.0 mg/kg i.v.) was investigated in the rat. Intravenous administration of L-arginine at doses of 0.26-2.63 g/kg at the time of cisplatin injection produced significant protection of renal function as evidenced by reductions in plasma urea and creatinine concentrations, decreased polyuria and increases in the plasma clearance of [3H]inulin and [14C]-p aminohippurate. Administration of D-arginine (2.63 g/kg i.v.) also significantly ameliorated the renal dysfunction induced by cisplatin although this protective effect was not as great as produced by the same dose of L-arginine. D-arginine, by contrast to its L-isomer, is reported to have little or no effect on renal haemodynamics. Consequently, the results of this study indicate that the protective effect of L-arginine in cisplatin nephrotoxicity involves both haemodynamic and nonhaemodynamic components.
Department of Pharmacology, University of Leeds, U.K.
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Li
C J
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Bowmer
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Yates
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D002945:Cisplatin / Q000633:toxicity*; D003404:Creatinine / Q000097:blood / Q000652:urine; D004305:Dose-Response Relationship, Drug; D007444:Inulin / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood / Q000652:urine; D014508:Urea / Q000097:blood / Q000652:urine; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
D014508:Urea; D007444:Inulin; D001120:Arginine; D012964:Sodium; D003404:Creatinine; D002945:Cisplatin; D010130:p-Aminohippuric Acid