Decreased voluntary ethanol selection in amygdala-kindled rats.
Kindled and control rats were exposed to either ethanol or dextrose solutions in the limited access paradigm, a paradigm that allows access to the test solution for only 1 h each day. Limited access trials were initiated either 24 h or 30 days after the fifth stage 5 seizure had been elicited in the kindled subjects. As previously reported, increased voluntary ethanol selection was observed in the limited access paradigm. Kindled subjects, however, ingested significantly less ethanol than controls. This difference was found both when limited access trials were started 24 h after the last seizure and when they were started 30 days after the last seizure. Kindled and control subjects did not differ in their intake of dextrose solutions.
Biobehavioral Research Department, Addiction Research Foundation, Toronto, Ontario, Canada.
M A
MA
Linseman
G
G
Cottrell
W M
WM
Burnham
D000428:Alcohol Drinking / Q000523:psychology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005947:Glucose / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000523:psychology
D005947:Glucose