Secondary chronic myelomonocytic leukemia with t(9;11) in a child.
Chronic myelomonocytic leukemia (CMMol) developed in a 10-year-old girl after treatment of non-Hodgkin's lymphoma with a regimen which did not contain epipodophyllotoxins. t(9;11)(p22;q23) was found in the leukemic cells. This case highlights the fact that secondary hemopoietic malignancies with 11q23 abnormalities are not restricted to patients treated with epipodophyllotoxins, expands the number of documented cases of secondary myelodysplasia in children, and adds CMMoL to the spectrum of hemopoietic malignancies associated with t(9;11).
George
R
R
Department of Child Health, University of Newcastle upon Tyne, U.K.
Pearson
A D
AD
Evans
J
J
Reid
M M
MM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002648:Child; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000188:drug therapy; D016609:Neoplasms, Second Primary / Q000235:genetics*; D011034:Podophyllotoxin / Q000009:adverse effects; D014178:Translocation, Genetic
D011034:Podophyllotoxin