Compressive properties of cortical bone: mineral-organic interfacial bonding.
Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties, orientation and interfacial bonding interactions. Interfacial bonding between the mineral and organic constituents is based, in part, on electrostatic interactions between negatively charged organic domains and the positively charged mineral surface. Phosphate and fluoride ions have been demonstrated to alter mineral-organic interactions, thereby influencing the mechanical properties of bone in tension. The present study explores the effects of phosphate and fluoride ions on the compressive properties of cortical bone.
Department of Orthopaedics, Brown University School of Medicine, Rhode Island Hospital, Providence 02903.
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Walsh
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Guzelsu
D000704:Analysis of Variance; D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002417:Cattle; D003902:Detergents / Q000494:pharmacology; D005269:Femur / Q000502:physiology; D008903:Minerals / Q000378:metabolism*; D017830:Octoxynol; D010710:Phosphates / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D011312:Pressure; D012969:Sodium Fluoride / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared
D003902:Detergents; D008903:Minerals; D010710:Phosphates; D011092:Polyethylene Glycols; D012969:Sodium Fluoride; D017830:Octoxynol; C010615:Nonidet P-40; C018279:sodium phosphate