Cell cycle controls: potential targets for chemical carcinogens?
The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be directly linked to genomic stability. Loss of the check-points involved in cell cycle control may result in unrepaired DNA damage during DNA synthesis or mitosis leading to genetic mutations and contributing to carcinogenesis.
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
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Afshari
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Barrett
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced / Q000473:pathology; D011506:Proteins / Q000502:physiology
D002273:Carcinogens; D011506:Proteins; D004247:DNA