[Effect of opioid receptor blockade with naloxone on secretion of atrial natriuretic peptide (ANP) in patients with kidney transplantation].
This paper aimed to assess the influence of opioid receptors on plasma level of atrial natriuretic peptide (ANP) in 12 kidney transplant patients (KTP) with stable graft function and in 15 healthy subjects (control). In KTP significantly higher plasma levels of ANP were found under basal conditions than in control subjects. After blockade of opioid receptors by naloxone a significant decline of plasma ANP was noticed, which was significantly more marked in KTP than in normals. Data obtained in this study suggest, that opioid receptors do influence plasma ANP levels both in KTP and healthy subjects. This influence seems to be significantly more marked in KTP than in normals. Hyperendorphinism seems to be involved in the pathogenesis of elevated plasma ANP levels in KTP.
Katedra i Klinika Nefrologii Sl.AM. Katowice.
W
W
Grzeszczak
E
E
Zukowska-Szczechowska
F
F
Kokot
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists; D012016:Reference Values
D009292:Narcotic Antagonists; D009270:Naloxone; D009320:Atrial Natriuretic Factor
Wpływ blokady receptorów opioidowych naloksonem na wydzielanie przedsionkowego peptydu natriuretycznego (ANP) u chorych z przeszczepiona nerka.