The importance of interferon-gamma in an early infection of Chlamydia psittaci in mice.
Athymic mice (nu/nu) and their hairy littermates (nu/+) were infected experimentally with Chlamydia psittaci and the role of endogenous interferon-gamma (IFN-gamma) on the resolution of the infection was studied. The pathological changes produced in the spleen, liver and lung were exacerbated by administration of a monoclonal antibody (mAb) to IFN-gamma and an increased number of viable chlamydiae were recovered from the tissues of both nu/+ and nu/nu mice treated in this way.
Moredun Research Institute, Edinburgh, U.K.
M C
MC
McCafferty
S W
SW
Maley
G
G
Entrican
D
D
Buxton
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002691:Chlamydophila psittaci / Q000302:isolation & purification; D007371:Interferon-gamma / Q000276:immunology*; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009929:Organ Size / Q000276:immunology; D009956:Psittacosis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013154:Spleen / Q000382:microbiology / Q000473:pathology
D000911:Antibodies, Monoclonal; D007371:Interferon-gamma