Tumor-localizing fluorescent diagnostic agents without phototoxicity.
In order to develop tumor-localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT-DO1 and has a molecular formula of m-phthalyl-([13,17-bispropanoic acid-3-ethenyl-8-formylethylidene-7-hydroxy-2,7,12,18-tetramethyl- porphyrinate]-manganese (III))-[3'-ethenyl-8'-formylethylidene-7'-hydroxy-2',7',12',18'-te tramethyl- porphine-13',17'-bispropanoyl aspartic acid]-bishydrazone.
Takemura
T
T
Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan.
Nakajima
S
S
Sakata
I
I
D000818:Animals; D006224:Cricetinae; D005456:Fluorescent Dyes / Q000737:chemistry; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000175:diagnosis*; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry
D005456:Fluorescent Dyes; D017319:Photosensitizing Agents; D011166:Porphyrins