Putative anticryptosporidial agents tested with an immunodeficient mouse model.
Lasalocid, sinefungin, and dehydroepiandrosterone were tested for anticryptosporidial activity with an immunodeficient mouse model at doses that have been reported effective when tested with immunosuppressed rodent models. Small but significant reductions in oocyst excretion were only observed under some conditions with lasalocid and dehydroepiandrosterone, but sinefungin had no effect.
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310.
G J
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Leitch
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D000241:Adenosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003049:Coccidiostats / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000469:parasitology*; D007832:Lasalocid / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013156:Splenectomy
D000981:Antiprotozoal Agents; D003049:Coccidiostats; D003687:Dehydroepiandrosterone; D000241:Adenosine; C006235:sinefungin; D007832:Lasalocid