Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.
The antiepileptic drugs phenytoin, valproic acid and phenobarbital were examined for their ability to inhibit N-methyl-D-aspartate (NMDA)-stimulated [3H]norepinephrine efflux from rat brain cortical slices. All three drugs inhibited efflux at varying concentrations. Valproic acid was the most potent and inhibited efflux at 0.01 mg/ml. Phenytoin and phenobarbital inhibited efflux at 0.1 mg/ml. These results indicate that some antiepileptic drugs are capable of inhibiting NMDA receptor function in the therapeutic range.
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-0095.
L M
LM
Brown
Y P
YP
Lee
T J
TJ
Teyler
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats
D000927:Anticonvulsants; D016202:N-Methylaspartate; D009638:Norepinephrine