Effect of low and high amounts of a structured lipid containing fish oil on protein metabolism in enterally fed burned rats.
To determine the optimal fat intake and source in nutritional support, we measured the protein-sparing effects of a structured lipid (SL) derived from 60% medium-chain triglyceride (MCT) and 40% fish oil and a 50:50 soybean to safflower oil emulsion (long-chain triglyceride, LCT). Male Sprague-Dawley rats received an enteral diet for 7 d with either all nonprotein energy as dextrose (control diet) or 10% or 35% nonprotein energy as SL or LCT. The rats were burned on day 3. Indirect calorimetry and nitrogen balance were measured on day 2 (preburn) and days 4 and 6 (postburn). Respiratory quotient decreased postburn. There was a significant increase in total energy expenditure postburn, particularly with 35% LCT. Nitrogen balance was best without fat and 10% fat compared with 35% fat and with SL compared with LCT. These results confirm previous studies that fish oil-containing SLs possess protein-sparing effects in burn injury and that 10% SL seems optimal for nutritional support in burn injury.
Laboratory of Nutrition/Infection, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215.
K J
KJ
Selleck
J M
JM
Wan
C J
CJ
Gollaher
V K
VK
Babayan
B R
BR
Bistrian
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D002056:Burns / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D004734:Energy Metabolism; D004750:Enteral Nutrition; D005227:Fatty Acids / Q000032:analysis; D005395:Fish Oils / Q000008:administration & dosage*; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry
D004041:Dietary Fats; D005227:Fatty Acids; D005395:Fish Oils; D011506:Proteins; D014280:Triglycerides; D009584:Nitrogen