T-cell development and function in gene-knockout mice.
The use of mice with defined genetic defects engineered by homologous recombination in embryonic stem cells has greatly enhanced our understanding of immune functions at the single-gene level. The complex molecular interactions involved in T-cell development and antigen recognition have been especially targeted for detailed analysis via knockout technology.
Amgen Research Institute, Ontario Cancer Institute, University of Toronto, Canada.
R S
RS
Yeung
J
J
Penninger
T W
TW
Mak
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout / Q000276:immunology*; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
D015703:Antigens, CD; D016207:Cytokines; D017260:Receptor-CD3 Complex, Antigen, T-Cell