Magnetic resonance imaging findings in Vogt-Koyanagi-Harada syndrome.
BACKGROUND
Vogt-Koyanagi-Harada Syndrome (VKHS) is a systemic disorder consisting of bilateral panuveitis with associated cutaneous and neurologic findings. In the absence of extraocular manifestations, diagnosis of VKHS may be difficult.


METHODS
The results of magnetic resonance imaging (MRI) in two patients with VKHS and of computed tomography (CT) in a third patient with VKHS are described.


RESULTS
Bilateral, diffuse choroidal thickening with scleral sparing was the norm. Choroidal thickening was demonstrable, despite the normal fundus appearance and fluorescein angiogram, in one eye. Intense enhancement after administration of gadopentetate was seen in the acute stages, but not after corticosteroid treatment. High-intensity periventricular lesions were seen in one patient.


CONCLUSIONS
MRI superbly discriminates the fibrous sclera from the choroid and allows for the detection of subclinical ocular and central nervous system disease. It is therefore a useful adjunct in the diagnosis and follow-up of VKHS.
Retina Consultans, St. Louis, Missouri 63110.
H E
HE
Ibanez
M G
MG
Grand
T A
TA
Meredith
F J
FJ
Wippold
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D002648:Child; D002829:Choroid / Q000473:pathology*; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D012163:Retinal Detachment / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis*
D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA