Inhibition of hemorrhagic activities of various snake venoms by purified antihemorrhagic factor obtained from Japanese Habu snake.
The ability of purified antihemorrhagic factor isolated from the serum of Japanese Habu (Trimeresurus flavoviridis) was tested on 17 snake venoms to inhibit their hemorrhagic activity. The factor strongly inhibited that of the venoms of Crotalus horridus horridus and Vipera latastei gaditana in addition to that of the homologous (T. flavoviridis) venom. Hemorrhagic activity of Agkistrodon halys blomhoffi, Agkistrodon contortrix contortrix, Bothrops atrox asper and Crotalus atrox venoms was also remarkably inhibited, but that of Vipera mauretanica to less extent. The hemorrhagic activities of nine other snake venoms were not inhibited.
Department of Biochemistry and Cell Biology, National Institute of Health, Tokyo, Japan.
T
T
Omori-Satoh
Y
Y
Nagaoka
Y
Y
Yamakawa
D
D
Mebs
D000818:Animals; D000997:Antivenins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001798:Blood Proteins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D011817:Rabbits; D012867:Skin / Q000187:drug effects; D012910:Snake Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity; D017841:Trimeresurus
D000997:Antivenins; D001798:Blood Proteins; D003435:Crotalid Venoms; D012910:Snake Venoms; C003941:antihemorrhagic factor