Synovial fluid lymphocyte proliferation to tuberculin protein product derivative: a novel way of diagnosing tuberculous arthritis.
We report a case of tuberculous arthritis in which the diagnosis was aided by lymphocyte proliferation assay to a panel of bacterial antigens. It illustrates that the lymphocyte proliferation assay may be a useful diagnostic tool in patients with tuberculous and reactive arthritis. It also supports the notion that there is a selective accumulation of antigen specific T cells at the site of inflammation in both septic and reactive arthritides.
United Medical and Dental Schools of Guy's, London, UK.
E H
EH
Choy
F
F
Chieco-Bianchi
G S
GS
Panayi
G H
GH
Kingsley
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis*; D006801:Humans; D007719:Knee Joint; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D013582:Synovial Fluid / Q000166:cytology* / Q000382:microbiology; D014373:Tuberculin / Q000494:pharmacology*; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy
D000995:Antitubercular Agents; D014373:Tuberculin