Formaldehyde-free collagen glue in experimental lung gluing.
Because of the well-known limitations of the adhesive strength of fibrin glue, it is imperative to develop a stronger glue with acceptable biocompatibility. This was accomplished by removing the formaldehyde component from gelatin-resorcinol-formaldehyde glue and replacing it by two less toxic aldehydes--pentanedial and ethanedial. To evaluate the adhesive strength of this new glue, GR-DIAL, lung incisions in rabbit hybrids were glued together. Each group (n = 5) was examined histologically after 2 days and 1, 2, and 4 weeks. The glue disintegrated gradually with good bioresorption when the incision was closed with a thin layer of glue. The healing process was favorable, indicating good biocompatibility. Therefore, GR-DIAL glue is capable of enhancing the use of surgical glues in the field of thoracic surgery by enabling surgeons to close larger parenchymal lesions than with fibrin glue.
Department of Cardiothoracic and Vascular Surgery, German Heart Institute, Berlin.
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Ennker
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Ennker
D
D
Schoon
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Schoon
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Rimpler
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R
Hetzer
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use*; D001673:Biodegradation, Environmental; D003094:Collagen / Q000737:chemistry* / Q000627:therapeutic use*; D004338:Drug Combinations; D005549:Foreign-Body Reaction / Q000473:pathology; D005557:Formaldehyde; D005780:Gelatin / Q000737:chemistry* / Q000627:therapeutic use*; D005976:Glutaral / Q000737:chemistry* / Q000627:therapeutic use*; D006037:Glyoxal / Q000737:chemistry* / Q000627:therapeutic use*; D006097:Granulation Tissue / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D008168:Lung / Q000473:pathology / Q000601:surgery*; D016676:Macrophages, Alveolar / Q000473:pathology; D010998:Pleurisy / Q000473:pathology; D011013:Pneumonectomy; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology; D011817:Rabbits; D012038:Regeneration; D012118:Resorcinols / Q000737:chemistry* / Q000627:therapeutic use*; D013908:Thoracotomy; D014014:Tissue Adhesives / Q000737:chemistry* / Q000627:therapeutic use*
D001672:Biocompatible Materials; D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C087754:gelatin-resorcinol-pentanedial-ethanedial adhesive; D005557:Formaldehyde; D006037:Glyoxal; D005780:Gelatin; D003094:Collagen; D005976:Glutaral; C031389:resorcinol