Secondary metabolites by chemical screening, 26.1 7-O-beta-D-galactosyl-brefeldin A via transglycosylation with Penicillium brefeldianum.
A lactose-containing fermentation medium initiated the formation of 7-O-beta-D-galactosyl-brefeldin A [1] in the brefeldin A-producing organism, Penicillium brefeldianum. The detection, isolation, and physicochemical properties of 1, which has been produced by biological derivatization via transglycosylation, are described. Compound 1 is the first glycosylated brefeldin A derivative to have been prepared.
Hoechst AG, Frankfurt, Germany.
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S
Grabley
R
R
Thiericke
J
J
Wink
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P
Henne
S
S
Philipps
P
P
Wessels
A
A
Zeeck
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003517:Cyclopentanes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D005697:Galactosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010407:Penicillium / Q000378:metabolism*
D000970:Antineoplastic Agents; D003517:Cyclopentanes; D005697:Galactosides; C088112:7-O-(galactosyl)brefeldin A