[Immunomodulator action of living, nonpathogenic Enterococcus faecalis bacteria from humans].
Immunomodulating Effect of Living Nonpathogenic Enterococcus faecalis Originated from Humans Symbioflor 1 is a pharmaceutical preparation, consisting of a suspension of living nonpathogenic Enterococcus faecalis (E. faecalis). The effect on the liberation of cytokines of E. faecalis was investigated in in-vitro experiments with human peripheral mononuclear blood cells revealing the following results: 1. E. faecalis stimulates the liberation of interleukin 1 (IL-1 beta) and interleukin-6 (IL-6) in a dose-dependent manner; the E. faecalis induced liberation of IL-1 beta and IL-6 is inhibited by dexamethasone (Dm) but not by cyclosporin A (CsA). 2. E. faecalis stimulates the liberation of gamma-interferon (IFN-gamma) in a dose-dependent manner, which is inhibited by both Dm and CsA. 3. Phytohemagglutinin (PHA)-induced liberation of gamma-IFN and interleukin-2 (IL-2) is inhibited by E. faecalis in a dose-dependent manner. The relevancy to clinical trials of the in vitro results is discussed.
INLUPA-Institut für Lebensmitteluntersuchungen, Umwelthygiene und Pharmakaanalytik GmbH, Mönchengladbach.
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Rosenkranz
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Grundmann
D000276:Adjuvants, Immunologic / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology; D016207:Cytokines / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D010835:Phytohemagglutinins; D003907:Dexamethasone; D007371:Interferon-gamma; D016572:Cyclosporine
Immunmodulatorische Wirkung lebender nicht-pathogener Enterococcus faecalis-Bakterien des Menschen.