Chemotactic response of unicellular Tetrahymena to a leukocyte attractant peptide and its repellent derivative: evolutionary conclusions.
Chemotactic properties of the leukocyte chemoattractant N-formyl-Norleucine-Leucine-Phenylalanine (NLP) and its antagonist N-t-BOC-Norleucine-Leucine-Phenylalanine (BOC-NLP) were investigated in unicellular Tetrahymena pyriformis cells. NLP express its attractant character in a two-peak profile of concentration course (maximum at 10(-8)-10(-7) M and 10(-11) M) while BOC-NLP has a constant repellent character (maximum at 10(-12) M). The observed homology of action concurs with our theory about the wide evolutionary background of signal molecules and receptors.
Kõhidai
L
L
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Kovács
P
P
Csaba
G
G
D000818:Animals; D005075:Biological Evolution; D002630:Chemotactic Factors / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D013769:Tetrahymena pyriformis / Q000187:drug effects / Q000502:physiology*
D002630:Chemotactic Factors; D009842:Oligopeptides; C024998:N-formylnorleucyl-leucyl-4-phenylalanine; C088189:N-tert-butyloxycarbonylnorleucyl-leucyl-phenylalanine