New approaches to amphibian limb regeneration.
Limb regeneration in urodele amphibians proceeds by the formation of a blastema, a growth zone of mesenchymal progenitor cells. Here, I review the origin of the blastema and its positional identity. The ability to culture and reimplant newt blastemal cells, and to transfect them in culture and in situ using a particle delivery system, has yielded new information about the action of retinoic acid on the blastema and the reversal of muscle differentiation during limb regeneration.
Brockes
J P
JP
Ludwig Institute for Cancer Research, University College London, UK.
D000818:Animals; D006614:Hindlimb / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000502:physiology; D012038:Regeneration; D014562:Caudata / Q000235:genetics / Q000502:physiology*
D018168:Receptors, Retinoic Acid