[Study on correlation and clinical significance of superoxide dismutase (SOD) activity and content in 102 patients with leukemia].
Serum superoxide dismutase (SOD) activity and blood Cu/Zn SOD content were examined in 102 cases of leukemia. The results showed that the total SOD activities, Cu/Zn SOD activities and contents declined significantly in blast phase of acute leukemia, yet increased to normal levels in remission. There was a positive correlation between SOD and blood hemoglobin concentration as well as leucocyte count. It declined again when leukemia recurred and in dying patients. There was a dissociation between Cu/Zn SOD activities and contents in patients with chronic granulocytic leukemia. In chronic lymphocytic leukemia, both activity and contents of SOD were normal. It was suggested that SOD plays a protective role during the occurrence and development of leukemia. SOD is a useful parameter in the differential diagnosis of leukemias and monitoring clinical course of leukemias.
Zhu
C S
CS
Affiliated Hospital, Qingdao Medical College.
Zhang
C Y
CY
Weng
W Q
WQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology*; D011379:Prognosis; D013482:Superoxide Dismutase / Q000097:blood*
D006454:Hemoglobins; D013482:Superoxide Dismutase