Derivative chromosome, der(17;22)(q10;q10), in two carcinomas of the cervix uteri and one of the skin.
In a previous study, we described 17p+ chromosomes in about 40% of carcinomas of the cervix, but it was usually not possible to identify the additional material on the short arm of the chromosome 17. Here we report an apparently identical rearranged chromosome in two squamous cell carcinomas of the cervix and one of the skin, in which the whole of 17p has been replaced by the long arm of a chromosome 22: der(17;22)(q10;q10), suggesting that this rearrangement may represent a significant step in the development of carcinomas of the cervix and other sites.
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, U.K.
N B
NB
Atkin
M C
MC
Baker
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*