Cervical mucus secretory IgA in adenomatous polyp, intraepithelial neoplasia and squamous cell carcinoma of the cervix.
Cervical mucus secretory IgA concentration ([sIgAc]) was significantly higher in 36 CIN (cervical intraepithelial neoplasia) patients than in 360, age, reproductive status and smoking habit-matched controls. Also, CIN ranked first compared with adenomatous polyp (29 cases), primary or secondary invasive esocervical carcinoma (IEC) (21), ectropion/erosion (49) and specific (27) or aspecific (80) cervicitis. CIN carried the highest proportion of cases with [sIgAc] detectable (86%) or beyond the cut-off value (33%) (IEC: 14% and 0%, respectively). [sIgAc] was inversely related to CIN grade and higher, though nonsignificantly, in patients with HPV-positive CIN biopsy specimens. Histologic and immunologic factors can account for the differences in [sIgAc] observed within the spectrum of neoplastic lesions of the cervix.
Department of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY.
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D018256:Adenomatous Polyps / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002582:Cervix Mucus / Q000166:cytology*; D002584:Cervix Uteri / Q000166:cytology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008597:Menstrual Cycle; D008875:Middle Aged; D017698:Postmenopause; D012016:Reference Values; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology*
D007071:Immunoglobulin A, Secretory