Acute tubular necrosis after interleukin-2 therapy.
Immunotherapy with interferon and interleukin-2 is being increasingly used in the treatment of metastatic renal cell cancer. A case is presented in which interleukin-2 (IL2) therapy was complicated by renal tubular necrosis. Renal function returned to normal following aggressive fluid replacement and use of dopamine and cautious diuresis.
Nzerue
M C
MC
Department of Internal Medicine, Texas Tech University Medical Center, Lubbock 79430.
D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary; D004232:Diuretics / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D005440:Fluid Therapy; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D007683:Kidney Tubular Necrosis, Acute / Q000097:blood / Q000139:chemically induced* / Q000628:therapy / Q000652:urine; D008297:Male; D008875:Middle Aged
D004232:Diuretics; D007376:Interleukin-2; D004298:Dopamine