Effect of clozapine treatment on serotonin-2-receptor binding in the blood platelets of schizophrenic patients.
The effect of clozapine and typical neuroleptic drug treatment on platelet serotonin2 (5-HT2) binding kinetic constants (Kd, Bmax) was studied in schizophrenic patients. Both treatments increased Bmax by a comparable amount, indicating increased numbers of 5-HT2 sites, although not all typical neuroleptic drugs were effective in this regard. Clozapine, but not typical neuroleptic drugs, increased Kd, indicating a lower affinity of the 5-HT2 sites for 5-HT. In a multiple regression model, low Bmax at baseline predicted poor outcome on Brief Psychiatric Rating Scale measures in the clozapine-treated patients but not the neuroleptic-treated patients.
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-5000.
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Arora
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Meltzer
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy
D011985:Receptors, Serotonin; D003024:Clozapine