CD23 and chronic lymphocytic leukemia.
Chronic lymphocytic leukemia (CLL) is classically defined by the proliferation and accumulation of monoclonal CD5 positive B cells "arrested" at an intermediate stage of differentiation. The CD23 antigen (the low affinity receptor for IgE (Fc epsilon RII) is a 45 kD membrane glycoprotein primarily expressed on surface IgM and IgD positive B cells. The aim of this paper is to establish the link between CD23 and CLL disease and to propose that the CD23 molecule is not simply a marker of CLL disease but may also be involved in the proliferation of the leukemic B cells.
Notre-Dame Hospital Research Center, University of Montréal, Canada.
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Sarfati
D015703:Antigens, CD / Q000097:blood* / Q000652:urine; D001402:B-Lymphocytes / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000276:immunology; D008213:Lymphocyte Activation; D017455:Receptors, IgE / Q000032:analysis* / Q000378:metabolism
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D017455:Receptors, IgE