[Glaucoma with Axenfeld-Rieger syndrome in three generations. Aqueous humor dynamics].
A 21-year-old woman was diagnosed as having glaucoma associated with Axenfeld-Rieger syndrome. Her family was examined and 3 additional patients with Axenfeld-Rieger syndrome were found in three generations. All of them had glaucoma with various types of onset. Aqueous humor dynamics were studied in 5 eyes of 3 patients using fluorophotometry. The basic secretion of aqueous humor in 5 eyes was 4.18 +/- 1.13 microliter/min. Averaged uveoscleral outflow in 3 eyes with low transtrabecular outflow facility was 61% of total aqueous outflow. It appeared that uveoscleral outflow was increased to compensate for the impaired transtrabecular outflow route.
Hayashi
M
M
Department of Ophthalmology, Jichi Medical School, Japan.
Inoda
S
S
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D000867:Anterior Chamber / Q000002:abnormalities*; D001082:Aqueous Humor / Q000502:physiology*; D005192:Family Health; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007498:Iris / Q000002:abnormalities*; D008297:Male; D008875:Middle Aged; D013577:Syndrome