Multimeric cytokine receptors: common versus specific functions.
The class I cytokine receptors consist of multiple subunits without any intrinsic enzymatic activities. Receptors for a subset of cytokines with overlapping biological activities often share a common receptor subunit with a signaling function. Each receptor regulates its specific signaling pathways, as well as common pathways depending on the target cell type.
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto.
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Sato
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Miyajima
D000818:Animals; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D046911:Macromolecular Substances; D008961:Models, Structural; D018121:Receptors, Cytokine / Q000737:chemistry* / Q000502:physiology*; D018123:Receptors, Interleukin / Q000737:chemistry / Q000145:classification / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000737:chemistry / Q000145:classification / Q000502:physiology; D016185:Receptors, Interleukin-3 / Q000737:chemistry / Q000145:classification / Q000502:physiology; D019947:Receptors, Interleukin-6; D015398:Signal Transduction
D015850:Interleukin-6; D046911:Macromolecular Substances; D018121:Receptors, Cytokine; D018123:Receptors, Interleukin; D015375:Receptors, Interleukin-2; D016185:Receptors, Interleukin-3; D019947:Receptors, Interleukin-6