The impact of gelatin-resorcinol glue on aortic tissue: a histomorphologic evaluation.
OBJECTIVE
Although gelatin-resorcinol-formaldehyde glue has been used to treat acute aortic dissections for some time, concerns about formaldehyde's mutagenicity and carcinogenicity made it imperative to develop a new glue compound. Gelatin-dialdehyde glue was produced by omitting the formaldehyde component and replacing it with two less toxic aldehydes, glutaraldehyde and glyoxal. This study evaluated the histomorphologic effects of the new glue through in vivo use on the aortic tissue of domestic pigs.


METHODS
Each animal's infrarenal aorta was glued around an implanted prosthesis. Histomorphologic evaluation was performed after operation after 1 and 4 weeks.


RESULTS
The results demonstrated that the clinically observed tanning effect can be attributed primarily to the disintegration of the fiber texture, specifically collagenous, as well as smooth muscle fibers, and to the reciprocal alterations of the proteoglycan interstitial substance in the aortic wall. Macroscopic, microscopic, and electron microscopic analysis of the gluing process revealed an adequate healing process without any morphologically significant difference between formaldehyde and formaldehyde-free gelatin-resorcinol glue.


CONCLUSIONS
Gelatin-dialdehyde glue is able to produce the same effects in the area of the aortic wall as the substantially more toxic gelatin-resorcinol-formaldehyde glue and thus could be recommended for clinical trials for treating acute aortic dissections thus far yielding excellent initial results.
Department of Cardiac, Thoracic, and Vascular Surgery, German Heart Institute Berlin, Germany.
J
J
Ennker
I C
IC
Ennker
D
D
Schoon
H A
HA
Schoon
S
S
Dörge
M
M
Meissler
M
M
Rimpler
R
R
Hetzer
D000818:Animals; D001012:Aorta, Abdominal / Q000033:anatomy & histology* / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D001807:Blood Vessel Prosthesis; D004338:Drug Combinations; D005557:Formaldehyde; D005780:Gelatin; D005976:Glutaral; D006037:Glyoxal; D012118:Resorcinols; D013552:Swine; D014014:Tissue Adhesives; D014945:Wound Healing
D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; C087754:gelatin-resorcinol-pentanedial-ethanedial adhesive; D005557:Formaldehyde; D006037:Glyoxal; D005780:Gelatin; D005976:Glutaral