[Expression and co-expression of cellular oncogenes in the course of tumor progression in neuroendocrine lung tumors].
The tumours studied were as follows: benign carcinoids, well differentiated carcinomas (atypical carcinoids) and poorly differentiated tumours (small-cell carcinoma with neuroendocrine differentiation). Oncoproteins c-myc, c-fos, c-jun, L-myc, c-sis, c-ras, c-src, c-ets-1, c-met were studied immunohistochemically in the material obtained from 25 patients during the operations. A higher expression of c-fos, c-jun, c-ets-1 and c-met is observed at early stages of progression and that of c-myc and L-myc at later stages. Enhancement of c-myc and L-myc expression correlated with the invasiveness and lymphogenic metastasizing. Co-expression and negative correlation between some oncogenes are established. The data obtained may be used for prognosis and therapy.
Kogan
E A
EA
Shtabskiĭ
A B
AB
Sekamova
S M
SM
Sukhova
N M
NM
Mazurenko
N N
NN
D000293:Adolescent; D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000032:analysis
D011518:Proto-Oncogene Proteins
Ekspressiia i koékspressiia kletochnykh onkogenov v khode opukholevoĭ progressii v neĭroéndokrinnykh opukholiiakh legkikh.