[Damages induced on DNA by oxygen-derived free radicals: pharmacological aspects].
Oxy-radicals can be generated at the cellular level by organic compounds displaying appropriated redox properties allowing one-electron transfer processes. Among the different molecules endowed with these properties, one can found a majority of cytotoxic antitumor agents whose mechanism of action involves the nuclear DNA degradation of the target cells. The nature of DNA damages produced by these antitumor agents using various experimental models is in agreement with the occurrence of oxy-radicals-mediated reactions. In most cases, a relationship between the redox properties and the action of these compounds at the molecular level is observed.
Auclair
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Laboratoire de Physicochimie et Pharmacologie des Macromolécules biologiques, CNRS URA 0147, Institut Gustave-Roussy, Villejuif.
D000970:Antineoplastic Agents / Q000494:pharmacology; D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects*; D004926:Escherichia coli / Q000235:genetics; D005609:Free Radicals / Q000494:pharmacology; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D005609:Free Radicals; D010100:Oxygen
Dommages induits sur l'ADN par les radicaux libres dérivés de l'oxygène: aspects pharmacologiques.