Variation in susceptibility of ten mouse strains to infection with a strain of Ehrlichia risticii.
Eight inbred strains of mice (A/J, AKR/NCrlBR, BALB/cAnNHsd, C3H/HeJ, C3H/HeNHsd, C57BL/6J, C57BL/10SnJ and CBA/J) and two outbred strains (CF1 and ICR) were inoculated with a strain of Ehrlichia risticii and their relative susceptibility to disease was determined. The strains varied widely in susceptibility, some showing profound illness, with illness being barely detectable in others. Severity of illness was uniform within strains. This study confirmed that the A/J and BALB/cAnNHsd strains were very susceptible to illness, but the C3H/HeJ, CBA/J and the CF1 strains were slightly less susceptible. The C57BL/6J, C57BL/10SnJ, C3H/HeNHsd, AKR/NCrlBR and ICR strains were resistant.
Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington 40546-0099.
N M
NM
Williams
P J
PJ
Timoney
D000818:Animals; D016873:Ehrlichiosis / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D051379:Mice / Q000276:immunology / Q000382:microbiology*; D008815:Mice, Inbred Strains / Q000276:immunology / Q000382:microbiology*; D013045:Species Specificity