Growth-promoting effects of glycine-extended progastrin.
Peptide alpha amidation is required to produce some hormones, such as gastrin, from their glycine-extended precursors. This terminal posttranslational processing reaction is thought to be essential for the biological activation of many peptide hormones; only amidated gastrin exerts a physiological effect that results in gastric acid secretion. However, both amidated gastrin and glycine-extended gastrin stimulate proliferation of exocrine pancreatic cell line AR4-2J through selective receptors for the substrate and the product, respectively, of peptide alpha amidation. Thus, the amidation reaction may function as a determinant of the specific biological actions of products derived from prohormones.
Seva
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Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.
Dickinson
C J
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Yamada
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D001570:Benzodiazepinones / Q000494:pharmacology; D001665:Binding Sites; D002455:Cell Division / Q000187:drug effects*; D005755:Gastrins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D015282:Octreotide / Q000494:pharmacology; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
D001570:Benzodiazepinones; D005755:Gastrins; D007211:Indoles; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C086854:glycine-extended gastrin 17; C065599:PD 134308; C058121:L 365260; C013550:gastrin 17; D008536:Meglumine; D009955:Ornithine Decarboxylase; D015282:Octreotide