Intra-arterial infusion of Tc-99m MAA: a case of highly selective targeting of liver metastases and shunting.
A patient with liver metastases and on angiotensin-converting enzyme inhibition for hypertension was studied after administration of Tc-99m MAA through the hepatic artery. The scintigrams showed a highly selective perfusion of the metastases (and significant shunting) despite the systemic treatment with a vasoactive drug that, theoretically, diminishes the flow to metastases. A possible effect of concomitant vasoactive medication on targeting and systemic side effects should be considered if regional perfusion studies and intra-arterial treatment are performed.
Department of Nuclear Medicine, Free University Hospital Amsterdam, The Netherlands.
J C
JC
Roos
G J
GJ
Teule
D004656:Enalapril / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects; D012811:Sigmoid Neoplasms / Q000473:pathology; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage
D013668:Technetium Tc 99m Aggregated Albumin; D004656:Enalapril; D005472:Fluorouracil