Serum cathepsin B levels, urinary excretion of cathepsin B and tissue cathepsin B content in the patients with gastric cancer.
Serum cathepsin B levels and urinary excretion of cathepsin B in the patients with gastric cancer were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue. After radical curative operations for gastric cancers, both serum cathepsin B levels and urinary excretion of cathepsin B were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor growth, and also suggest that these parameters might be possible indicators for tumor malignancy.
Department of Surgery, Yoshioka Hospital, Kyoto, Japan.
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Hirano
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Yoshioka
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002401:Cathepsin B / Q000378:metabolism*; D005260:Female; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology*
D014408:Biomarkers, Tumor; D002401:Cathepsin B