The metabolism of ethosuximide.
The metabolism of the antiepileptic drug ethosuximide (3-ethyl-3-methylpyrollidine-2,5-dione) (I) in animals and humans is reviewed. Chiral aspects of the metabolism of ethosuximide are discussed. Clarification of the precise nature of the hydroxymetabolites of ethosuximide is presented.
Millership
J S
JS
School of Pharmacy, Queen's University of Belfast, UK.
Mifsud
J
J
Collier
P S
PS
D000818:Animals; D005013:Ethosuximide / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans
D005013:Ethosuximide