[Central inhibition action of Valeriana jatamansii Jones].
The use of water extract (ip or ig) of Valeriana jatamansii together with pentobarbital sodium can enhance sedative and hypnotic effect in mice, inhibit the spontaneous activity in mice, and antagonize convulsive action induced by thiosemicarbazide (TSZ). Although ineffective on the convulsion induced by picrotoxin (PT), it can prolong the latent period of convulsion induced by PT in mice. The number of writhings in mice can be reduced after ip or ig water extract.
Guangxi Institute of Traditional Chinese Medical and Pharmaceutical Sciences, Nanning.
B
B
Cao
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GX
Hong
D000700:Analgesics / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use / Q000633:toxicity; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010852:Picrotoxin; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D012663:Semicarbazides
D000700:Analgesics; D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D010424:Pentobarbital; D010852:Picrotoxin; D012663:Semicarbazides; C005151:thiosemicarbazide