Trisomy 6 as the sole chromosome abnormality in myeloid disorders.
Trisomy 6 was the sole chromosomal abnormality detected in two patients with myeloid disorders in relapse. One had a refractory anemia with excess of blasts and the other acute myeloblastic leukemia. Simple trisomy 6 has been reported in patients with myeloid disorders, marrow hypoplasia, acute myeloid leukemia, and "preleukemia." The prognostic significance of this nonrandom chromosomal abnormality is discussed.
Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
P
P
Jonveaux
P
P
Fenaux
R
R
Berger
D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy