Effects of a low-insulin-response, energy-restricted diet on weight loss and plasma insulin concentrations in hyperinsulinemic obese females.
The effects of two low-energy diets on serum insulin concentrations and weight loss in obese hyperinsulinemic females were compared during a 12-wk period. The first diet (n = 15) was designed to evoke a low insulin response (ID), and the second (n = 15) was a conventionally balanced diet (ND). After a 12-wk washout period, seven and nine subjects who had been on the ID and ND, respectively, changed to the alternative diet for 12 wk. Variables studied were basal and 30- and 120-min concentrations of blood glucose, insulin, and C-peptide after an oral glucose load; body weight; and energy intake. Mean (+/- SD) weight was significantly reduced after ID and ND (9.35 +/- 2.49 and 7.41 +/- 4.23, respectively). The mean weight loss was more after ID. Fasting insulin concentrations decreased more after ID compared with ND (91.3 +/- 61.8 vs 21.0 +/- 71.5 pmol/L; P < 0.05). We conclude that ID significantly reduces serum insulin concentrations and weight in obese hyperinsulinemic females.
Slabber
M
M
Department of Human Nutrition, University of the Orange Free State, Bloemfontein, South Africa.
Barnard
H C
HC
Kuyl
J M
JM
Dannhauser
A
A
Schall
R
R
D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D003927:Diet, Diabetic; D002149:Energy Intake; D005215:Fasting / Q000378:metabolism; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D009765:Obesity; D015431:Weight Loss
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin