[Immunologic parameters in women with normal pregnancy and pre-eclampsia].
Immunological investigations were carried in women with normal pregnancy and patients with preeclampsia. Regarding the lymphocyte subpopulation distribution an elevated number of T lymphocytes, especially of CD-4 carrying helper-inducer T cells, was registered resulting in an altered CD4/CD8 ratio. The T lymphocytes in patients with pre-eclampsia seem to be activated in vivo, shown by an elevated expression of the CD25 (IL-2 receptor) marker. Their responsibility to phytohemagglutinin (PHA) in vitro was found to be depressed. Furthermore, a pre-stimulation of macrophages in vivo was registered (expression of the transferrin receptor). In comparison to the control group the serum levels of IgG and IgA were seen to be low in patients with pre-eclampsia.
Frauenklinik der Charité, Universitätsklinikum Berlin.
S
S
Bettin
H
H
Halle
B M
BM
Wenzkowski
H D
HD
Volk
S
S
Jahn
D000328:Adult; D015703:Antigens, CD / Q000097:blood; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D012016:Reference Values; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D007136:Immunoglobulins
Immunologische Parameter bei Frauen mit normal verlaufender Schwangerschaft und Präeklampsie.