8-OH-DPAT induces a selective increase in protein intake in ageing overweight animals.
We have examined the effects of a 5-HT1A receptor agonist (8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT) on food preference in ageing rats that had been given a 'palatable' meal 15 min before administration of the drug. Ageing rats consumed a greater amount of the 'palatable' pre-meal than the young rats. In young rats lipids were the predominant source of calories, but in old animals lipid and protein consumption was similar. Administration of 8-OH-DPAT resulted in an increase in total caloric intake in both groups. Concomitant with this there was a significant increase in protein intake in both groups, which was most important in ageing rats, where proteins became the predominant source of calories.
Division of Metabolic Diseases, Institut de Recherches Servier, Suresnes, France.
F
F
Lacour
S
S
Berger
J
J
Espinal
J
J
Duhault
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000375:Aging / Q000523:psychology*; D000818:Animals; D004032:Diet; D004044:Dietary Proteins; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects; D015228:Hypertriglyceridemia / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000523:psychology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004044:Dietary Proteins; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin