[Occurrence of free receptor for interleukin 2 in serum and quantitative determinations of CD25+ in patients infected with HIV].
Serum soluble interleukin 2 receptor (sIL-2R) concentration and the percentage of lymphocytes presenting this receptor (CD25+) were investigated in 28 asymptomatic HIV carriers or patients with lymphadenopathy only and in 15 AIDS patients. The levels of sIL-2R were found to be higher in AIDS patients (mean 1060 U/ml) than in persons during the initial stages of infection (mean 750 U/ml) or controls (mean 470 U/ml). No significant differences in the quantity of CD25+ lymphocytes between these groups were observed, with the means of 1.0; 1.3 and 1.1, respectively. However, a decrease in percentage of these cells were found in patients with advanced HIV infection. Since sIL-2R is regarded as a marker of immune system activation its detection could be helpful in the assessment of the immune status impairment in HIV infected patients.
Radkowski
M
M
Zakład Immunopatologii, Instytut Chorób Zakaźnych i Pasozytniczych Akademii Medycznej, Warszawie.
Kopicz-Kamińska
E
E
Laskus
T
T
Rogers
S
S
Babiuch
L
L
Slusarczyk
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology*; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D015415:Biomarkers; D015375:Receptors, Interleukin-2
Wystepowanie wolnego receptora dla interleukiny 2 w surowicy oraz oznaczenia ilościowe limfocytów CD25+ u pacjentów zakazonych HIV.