[The mechanisms of the intensification of free radical processes in patients with IHD-stenocardia in relation to its severity].
The ability of leukocytes to generate active oxygen forms and plasmic levels of malonic dialdehyde as indicators of free radical process activity and that of lipid peroxidation (POL), respectively, were investigated in 50 patients with angina pectoris (20 patients with functional class I-II and 30 patients with functional class III-IV) versus 18 donors. The anginal patients are shown to have enhanced POL and free radical processes which appeared correlated with the disease severity. The authors identify factors intensifying free radical processes in anginal patients: platelet inhibition of leukocytic ability to generate active oxygen forms, changes in plasmic levels of IgM, C-reactive protein, serum iron.
Kogan
A Kh
AKh
Ershov
V I
VI
Sokolova
I Ia
IIa
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D005082:Physical Exertion
D005609:Free Radicals; D008315:Malondialdehyde
O mekhanizmakh usileniia svobodnoradikal'nykh protsessov u bol'nykh IBS--stenokardieĭ v zavisimosti ot ee tiazhesti.