[Cell interactions in the extracellular matrix in tumoral invasion in mammary pathology].
Tumoral invasion in breast lesions is associated with a progressive loss of the basement membrane (BM) components. In situ hybridization reveals a loss of synthetic ability of type IV collagen by invasive cells in a murine model. The loss of BM components does not seem related to the expression of the plasmin system by cancer cells. By contrast, there is a cooperation between fibroblasts and cancer cells for the expression of matrix metallo-proteinases involved in BM degradation in breast carcinomas in vivo.
INSERM U 314 CHU de Reims.
C
C
Clavel
M
M
Polette
P
P
Birembaut
D000818:Animals; D001485:Basement Membrane / Q000737:chemistry / Q000378:metabolism; D001943:Breast Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D005109:Extracellular Matrix / Q000473:pathology*; D006801:Humans; D017403:In Situ Hybridization; D015674:Mammary Neoplasms, Animal / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H; D009361:Neoplasm Invasiveness
Interactions cellules matrice extra-cellulaire au cours de l'invasion tumorale en pathologie mammaire.