Physiological and environmental aspects of drinking stimulated by chronic exposure to amphetamine in rats.
1. To examine whether the hyperdipsic response to chronic administration of d,l-amphetamine (AMPH) is associated with modification of salt appetite, rats were allowed to choose between tap water and a 1.7% NaCl solution. 2. Under AMPH rats preferred water to saline throughout the experiment. 3. By testing rats in a distinct test cage environmental influences on AMPH-mediated hyperdipsia were also evaluated. 4. In the test cage hyperdipsia was suppressed, but preference for tap water was preserved. 5. Finally, the role of alpha 2-adrenoceptors in the drinking response to AMPH was evaluated by studying the effects of clonidine and yohimbine on water intake. 6. We conclude that AMPH-induced preference for tap water over saline is unrelated to hyperdipsia but, being also induced by yohimbine, it may depend on noradrenergic mechanisms.
Institute of Medical Pharmacology, University La Sapienza, Rome, Italy.
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D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm; D003000:Clonidine / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D004777:Environment; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; D012965:Sodium Chloride; D000661:Amphetamine; D003000:Clonidine