DNA replication: enzymology and mechanisms.
Research into the enzymology of DNA replication has seen a multitude of highly significant advances during the past year, in both prokaryotic and eukaryotic systems. The scope of this article is limited to chromosomal replicases and origins of initiation. The multiprotein chromosomal replicases of prokaryotes and eukaryotes appear to be strikingly similar in structure and function, although future work may reveal their differences. Recent developments, elaborating the activation of origins in several systems, have begun to uncover mechanisms of regulation. The enzymology of eukaryotic origins has, until now, been limited to viral systems, but over the past few years, enzymology has caught a grip on the cellular origins of yeast.
Kelman
Z
Z
Department of Microbiology, Cornell University Medical College, New York, New York 10021.
O'Donnell
M
M
D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000201:enzymology; D006801:Humans; D011387:Prokaryotic Cells / Q000201:enzymology
C023140:DNA replicase; D004259:DNA-Directed DNA Polymerase