Expanding horizons for receptors coupled to G proteins: diversity and disease.
The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand detection. These and other developments promise continued excitement in this field.
Coughlin
S R
SR
Cardiovascular Research Institute, University of California, San Francisco 94143-0524.
D017398:Alternative Splicing; D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008961:Models, Structural; D009154:Mutation; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins