Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes.
Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and 30 following S180 challenge, a decrease in this effect on IL-1 production in treated and untreated SMAc was observed. Concomitantly with the alterations in the regulation of IL-1 production during tumor growth, an increase in the levels of prostaglandin E2 and serum immune complexes could be detected. These data suggest that the immunosuppression associated with later stages of tumor development may be due to direct effects on monocytes, by means of a down-regulation of IL-1 production.
Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.
N A
NA
Chasseing
E M
EM
Eugui
E S
ES
Borda
L
L
Rumi
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood*; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D015232:Dinoprostone / Q000378:metabolism; D004926:Escherichia coli; D005069:Evaluation Studies as Topic; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000097:blood / Q000473:pathology* / Q000503:physiopathology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D000936:Antigen-Antibody Complex; D007375:Interleukin-1; D008070:Lipopolysaccharides; D015232:Dinoprostone