Limited effects of temafloxacin compared with ciprofloxacin on T-lymphocyte function.
Temafloxacin increased interleukin-2 production and mRNA levels and enhanced thymidine incorporation in stimulated lymphocyte cultures. Gamma interferon mRNA levels were unaffected. Temafloxacin also stimulated interleukin-2 gene induction, as revealed in a chloramphenicol acetyltransferase reporter gene system. However, temafloxacin exerted significantly weaker effects in these respects than did ciprofloxacin.
Department of Medical Microbiology, Lund University, Malmö General Hospital, Sweden.
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Riesbeck
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Forsgren
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001345:Autoradiography; D015152:Blotting, Northern; D002478:Cells, Cultured; D002939:Ciprofloxacin / Q000494:pharmacology*; D024841:Fluoroquinolones; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D010835:Phytohemagglutinins / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007376:Interleukin-2; D010835:Phytohemagglutinins; D015363:Quinolones; D012333:RNA, Messenger; C054745:temafloxacin; D002939:Ciprofloxacin; D007371:Interferon-gamma; D013936:Thymidine