The American experience with desmopressin.
Conclusive evidence of a polyuric etiology from a failure of vasopressin elevation led to a new pharmacologic approach to the treatment of childhood nocturnal enuresis. Desmopressin acetate, a vasopressin analogue, has been used successfully since 1978 to treat this condition. Desmopressin's efficacy at doses of 5 to 40 micrograms has been demonstrated in Europe and the United States. Similarly, its safety has been established, and it is a first-line choice for physicians worldwide.
Bloom
D A
DA
University of Michigan, Ann Arbor 48109-0330.
D002648:Child; D002986:Clinical Trials as Topic; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D004775:Enuresis / Q000188:drug therapy* / Q000209:etiology*; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D012449:Safety; D014481:United States; D014667:Vasopressins / Q000172:deficiency
D014667:Vasopressins; D003894:Deamino Arginine Vasopressin