[Synthesis and pharmacologic examination of derivatives of benzoxazaphosphoryl-4-one and 2-phenyl-10-methyl-3a-triethoxyphosphone-1H,2,3,9,10-tetrahydropyrrolo [3,4-b][1,4]benzoxazepine-1,3,9-trione].
A series of N-derivatives of 2-phenyl-2,3-dihydro-1,3,2(lambda 5)- benzoxazaphosphoryl-4-one and 2-phenyl-10-methyl-3a-triethoxyphosphonio- 1H,2,3,9,10-tetrahydropyrrolo[3,4-b]([1,4]benzoxazepine-1,3,9-trio ne have been prepared. The pharmacological investigation of the above mentioned compounds shows antitumor action against leukaemia in the case of three N-derivatives.
Zakład Chemii Nieorganicznej, Instytut Chemii, Akademia Medyczna, Lódź.
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D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D010077:Oxazepines / Q000138:chemical synthesis / Q000494:pharmacology*
D009943:Organophosphorus Compounds; D010077:Oxazepines; C088255:2-phenyl-2,3-dihydro-1,3,2(lambda(5))-benzoxazaphosphoryl-4-one; C088256:2-phenyl-10-methyl-3a-triethoxyphosphonio-1H-2,3,9,10-tetrahydropyrrolo(3,4-b)(1,4)benzoxazepine-1,3,9-trione
Synteza i badania farmakologiczne pochodnych benzoksazafosforyno-4-on i 2-fenylo-10-metylo-3a-trietoksyfosfonio-1H,2,3,9,10-tetrahydropirolo [3,4-b][1,4] benzoksazepino-1,3,9-trionu.