[Effects of processing on special toxicity and pharmacodynamics in semen Armeniacae amarum].
The ethereal extract and decoction from raw Semen Armeniacae Amarum were found to induce EBV-EA activation in Raji cells cultured in vitro. Experiments show that both the extract and decoction have tumor-promoting activities, but the EBV-EA activation can be decreased by three kinds of processing-parching, scalding or parching after scalding, of which parching and parching after scalding are better. Moreover, parching after scalding is the best to enhance the relaxing of bowels, inactivate the amygdalase and increase the decoction rate of amygdalin.
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
A H
AH
Liang
S Q
SQ
Nie
B Y
BY
Xue
G Q
GQ
Li
Z L
ZL
Li
D000678:Amygdalin / Q000032:analysis*; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006358:Hot Temperature; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
D000956:Antigens, Viral; D004365:Drugs, Chinese Herbal; C033305:Epstein-Barr virus early antigen; D000678:Amygdalin