[Experimental chemotherapy of echinococcosis. 13. The effect of mebendazole in combination with a vegetable oil on the larval cysts of Echinococcus multilocularis and the reaction of the infested host to long-term administration of the preparation].
The use of mebendazole as a suspension in vegetable oil enhanced the efficiency of treating experimental Echinococcus granulosus infection in outbred albino rats without increasing the dose of the drug. A sharp reduction in platelet count in the blood of the infected animals treated and untreated suggests that thrombohemorrhagic complications might be in echinococcosis. Thrombopenia in the treated animals appeared to be steady-state. A decrease in a rapid immune response in the mebendazole-treated rats, as compared to the untreated ones, is likely to be a consequence of a significant fall of antigenic immune stimulation due to suppression of the parasite's viability with the drug and to be an indicator of therapeutical efficiency.
Dzhabarova
V I
VI
Veretennikova
N L
NL
Kovrova
E A
EA
D000818:Animals; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D004446:Echinococcus / Q000187:drug effects*; D006368:Helianthus; D006790:Host-Parasite Interactions; D007814:Larva / Q000187:drug effects; D008463:Mebendazole / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D000074242:Sunflower Oil; D013997:Time Factors
D004337:Drug Carriers; D010938:Plant Oils; D000074242:Sunflower Oil; D008463:Mebendazole
Eksperimental'naia khimioterapiia ékhinokokkozov. Soobshchenie 13. Vliianie mebendazola v sochetanii s rastitel'nym maslom na larvotsisty mnogokamernogo ékhinokokka i reaktsiia invazirovannogo khoziaina na dlitel'noe vvedenie preparata.