Translocation (3;21)(q26;q22) in treatment-related acute leukemia secondary to acute promyelocytic leukemia.
We performed cytogenetic studies in a patient with treatment-related acute leukemia (t-AL) to identify the associated chromosomal changes. Metaphase analysis revealed a t(3;21)(q26;q22) translocation. Acute promyelocytic leukemia (APL) had been diagnosed 4 years earlier and the patient had received intensive induction chemotherapy and sequential post-induction therapy that included agents that targeted DNA-topoisomerase II (topo II). This case suggests an association between previous therapy with topo II inhibitors and development of t-AL associated with a balanced aberration involving the 3q26 and 21q22 bands.
Department of Medicine, Fujita Health University, School of Medicine, Aichi, Japan.
H
H
Miyazaki
T
T
Ino
R
R
Sobue
H
H
Kojima
M
M
Wakita
T
T
Nomura
M
M
Tuzuki
M
M
Hirano
D000208:Acute Disease; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000139:chemically induced*; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D059005:Topoisomerase II Inhibitors
D059005:Topoisomerase II Inhibitors