Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts.
The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed to noise showed attenuated cochlear action potential threshold (CAP) shifts and cochlear microphonic (CM) when compared to non-drug treated noise-exposed subjects. These data suggest that inhibition of FOR induced lipid peroxidation is an important mechanism in noise-induced asymptotic temporary threshold shifts.
Quirk
W S
WS
Department of Otolaryngology, Wayne State University, Detroit, Michigan.
Shivapuja
B G
BG
Schwimmer
C L
CL
Seidman
M D
MD
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001309:Auditory Threshold / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009622:Noise / Q000009:adverse effects; D011281:Pregnatrienes / Q000494:pharmacology*; D051381:Rats; D011921:Rats, Inbred WKY
D000975:Antioxidants; D011281:Pregnatrienes; C074965:U 74389F