Homocysteate-like immunoreactivity in multiform glioblastoma of human brain.
Anti-homocysteate antibodies with postembedding immunohistochemistry for light microscopy were used to localize homocysteate-like immunoreactivity in human multiform glioblastoma. The most remarkable stained elements (6.8% of the total tumoral tissue) corresponded to distinct astrocytic cell bodies, intermingled fibrous processes and puncta of diverse size, some of them closely apposed to capillaries. In not affected peritumoral tissue, on the other hand, numerous labelled dots resembling portions of glial processes were observed in the neuropil and around blood vessels (2.7% of the total peritumoral tissue). However, glial and neuronal cell bodies could not be detected. These observations extend to a human brain tumor of glial nature the knowledge on the preferential localization of homocysteate in glia.
Department of Neurosciences, Faculty of Medicine and Dentistry, Basque Country University, Bilbao, Spain.
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F
Ortega
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I
Pomposo
P
P
Streit
P
P
Grandes
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology*; D003429:Cross Reactions; D005909:Glioblastoma / Q000473:pathology*; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology
D006710:Homocysteine; C007956:homocysteic acid