R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers.
The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 micrograms/min/kg body wt) reduced blood pressure in a dose-dependent fashion; the mean arterial blood pressure at the end of the infusion fell from 128 +/- 4/83 +/- 4 to 119 +/- 3/71 +/- 3 mm Hg (mean +/- SEM) (P < .01) during the low sodium intake diet. R-PEP-27 had no effect on blood pressure during the high sodium intake diet. R-PEP-27 significantly reduced plasma angiotensin II and aldosterone concentrations. The temporal response to R-PEP-27 suggests that it is a short-lived although highly potent competitive inhibitor of renin; this peptide is a valuable and specific physiologic probe of the renin-angiotensin system.
Division of Hypertension and Vascular Medicine, Massachusetts General Hospital, Boston 02114.
R M
RM
Zusman
K Y
KY
Hui
J
J
Nussberger
D M
DM
Christensen
J
J
Higgins
W D
WD
Carlson
D
D
Schoenfeld
E
E
Haber
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000009:adverse effects / Q000494:pharmacology*; D009994:Osmolar Concentration; D012016:Reference Values; D014556:Urine / Q000737:chemistry; D000092502:Renin Inhibitors
D000450:Aldosterone; D000804:Angiotensin II; D009842:Oligopeptides; D000092502:Renin Inhibitors; C088339:renin inhibitory peptide, R-PEP-27