Interferon-activated signal transduction to the nucleus.
Recent studies on gene activation by interferons have uncovered a direct signaling pathway from the cell-surface receptor for interferons to the nucleus. Activation of JAK tyrosine kinases by interferons leads to activation, by direct tyrosine phosphorylation, of a family of latent cytoplasmic transcription factors named STATs (for signal transducers and activators of transcription), which then translocate to the nucleus to direct transcriptional activation.
Shuai
K
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Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology*; D008969:Molecular Sequence Data; D015398:Signal Transduction; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D007370:Interferon Type I; D007371:Interferon-gamma