Reliability of single urine and serum samples for estimation of 24-hour urinary uric acid excretion in six healthy beagles.
Urine uric acid-to-urine creatinine ratios (UUA:UC), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a 10.4% protein (dry weight), casein-based diet and a 31.4% protein (dry weight), meat-based diet. The UUA:UC, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were not reliable estimates of 24-hour urinary uric acid excretions during consumption of either diet. Urine uric acid concentrations in samples collected 2, 4, 6, and 24 hours after initiation of collection correlated with 24-hour urinary uric acid excretions when dogs consumed the casein-based diet; correlation was not found at any time interval when dogs consumed the meat-based diet. Therefore, determination of 24-hour urinary uric acid excretion is recommended because UUA:UC are unreliable.
Bartges
J W
JW
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
Osborne
C A
CA
Felice
L J
LJ
Unger
L K
LK
Bird
K A
KA
Koehler
L A
LA
Chen
M
M
D000818:Animals; D003404:Creatinine / Q000652:urine*; D004032:Diet; D004285:Dogs / Q000097:blood / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D015203:Reproducibility of Results; D014527:Uric Acid / Q000097:blood / Q000652:urine*
D014527:Uric Acid; D003404:Creatinine