Immunity to Haemophilus influenzae type b polysaccharide capsule in children with human immunodeficiency virus infection immunized with a single dose of Haemophilus vaccine.
We studied immunity to Haemophilus influenzae type b (Hib) polysaccharide capsule in 19 children infected with human immunodeficiency virus (HIV) immunized with a single dose of a Hib vaccine at a mean age of 28 months (range, 15 to 56 months). Four to eighty-five months after immunization, only 7 children (37%) were immune. There were no significant differences in the HIV classification of the Centers for Disease Control and Prevention, type of conjugate vaccine, age at vaccination or serologic testing, time from vaccination to antibody determination, and CD4 cell counts between children with and those without immunity.
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York.
V B
VB
Peters
S K
SK
Sood
D000907:Antibodies, Bacterial / Q000097:blood*; D016667:Bacterial Capsules; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000276:immunology*; D002675:Child, Preschool; D015658:HIV Infections / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007223:Infant; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology*
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial; C061963:HibTITER protein, Haemophilus influenzae