The migration of bone marrow cells to thymic culture supernatants is inhibited by stress.
The effect of immobilization stress on precursor cell migration from bone marrow to the thymus was studied in C57BL/6 mice. The in vitro migration assays, using Nucleopore chambers, showed that precursor cell migration to thymus supernatants was strongly inhibited in stressed animals. This inhibition of migration seemed to be cell-associated what can explain the thymic involution observed in mice under stress conditions. The migration of precursor cells from bone marrow may be one of the mechanisms by which the thymus gland is involuted by stress.
Departamento de Bioquímica e Bioloxía Molecular, Facultade de Bioloxía, Universidade de Santiago, A Coruña, Spain.
M L
ML
Pérez-Mera
M
M
Freire-Garabal
T
T
Alvarez-Martínez
M
M
Rey-Méndez
D000818:Animals; D000831:Animals, Newborn; D001854:Bone Marrow Cells; D002465:Cell Movement; D002478:Cells, Cultured; D007103:Immobilization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013950:Thymus Gland / Q000166:cytology*