[The antimicrobial action of a liposomal preparation lipin].
A possibility of the use of lipine, liposomal drug, to decrease manifestations of the basic inflammatory effect: tissue edema in the region of pathological focus, as well as the drug effect on the growth of pathogenic microflora (gonococcus, Staphylococcus aureus) inoculated in the patients with gonorrheal and bacterial urethritis and urethroprostatitis has been experimentally studied. The laboratory experiments were carried out on the mature white mice. The inflammatory edema of hindlimb soft tissues was evoked by the subplantar administration of 0.1 ml of 2% formalin solution. The extent of edema development was determined by oncometry 1, 2, 4, 8 and 24 h after formalin administration. Lipine was 2.5 and 10 times dissolved by physiological solution and subplantarily administered to the animals (10 mice in each group) in a dose of 0.1 ml 1 h before administration of formalin solution. Physiological solution was used in the control group instead of lipine. It is established that the preliminary introduction of lipine decreased (more than by 50%) the degree of development of the tissue edema as compared to the control group. Bactericide properties of lipine have been studied on the suspensions of diurnal cultures of gonococcus and Staphylococcus aureus. The investigations were carried out by the methods of serial dissolutions (lipine concentration in the suspension on physiological solution was 1, 5, 10, 20 and 30 mg/ml). The results of observations have shown that the incubation of the agent of urogenital infections (gonococcus, streptococcus aureus) with lipine vesicules lead to partial or even complete suppression of the bacterial growth.(ABSTRACT TRUNCATED AT 250 WORDS)
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000890:Anti-Infective Agents; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D006069:Gonorrhea / Q000188:drug therapy; D008081:Liposomes / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D009930:Organic Chemicals; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008081:Liposomes; D009930:Organic Chemicals; C088310:lipine
Antimikrobnoe deĭstvie liposomal'nogo preparata--lipina.