Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage.
In contrast to patients with disseminated intravascular coagulation (DIC) due to other causes, patients with acute promyelocytic leukemia (APL) receiving standard cytotoxic chemotherapy can be treated safely with antifibrinolytic drugs for prophylaxis of hemorrhage, without the occurrence of thromboembolic complications. However, such drugs should be used cautiously in APL patients who are receiving all-trans retinoic acid (ATRA) differentiation therapy. We report here a patient with APL who had fatal thromboembolism after receiving ATRA and tranexamic acid therapy.
First Department of Internal Medicine, Niigata University School of Medicine, Japan.
S
S
Hashimoto
T
T
Koike
W
W
Tatewaki
Y
Y
Seki
N
N
Sato
T
T
Azegami
N
N
Tsukada
H
H
Takahashi
H
H
Kimura
M
M
Ueno
D058186:Acute Kidney Injury / Q000139:chemically induced; D000933:Antifibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004347:Drug Interactions; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy*; D008875:Middle Aged; D013923:Thromboembolism / Q000139:chemically induced*; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use*
D000933:Antifibrinolytic Agents; D014212:Tretinoin