Acute tubular necrosis after interleukin-2 therapy.
Immunotherapy with interferon and interleukin-2 is being increasingly used in the treatment of metastatic renal cell cancer. A case is presented in which interleukin-2 (IL2) therapy was complicated by renal tubular necrosis. Renal function returned to normal following aggressive fluid replacement and use of dopamine and cautious diuresis.
Department of Internal Medicine, Texas Tech University Medical Center, Lubbock 79430.
M C
MC
Nzerue
D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary; D004232:Diuretics / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D005440:Fluid Therapy; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D007683:Kidney Tubular Necrosis, Acute / Q000097:blood / Q000139:chemically induced* / Q000628:therapy / Q000652:urine; D008297:Male; D008875:Middle Aged
D004232:Diuretics; D007376:Interleukin-2; D004298:Dopamine