Effect modelling for drugs undergoing enterohepatic circulation.
A multi-compartment pharmacokinetic model with enterohepatic circulation, was used in simulations and in a clinical trial with morphine. A hypothetical effect compartment was linked to either the central or the peripheral disposition compartment.
Höglund
P
P
Department of Clinical Pharmacology, University Hospital of Lund, Sweden.
Ohlin
M
M
D001646:Bile / Q000378:metabolism; D004764:Enterohepatic Circulation; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008954:Models, Biological; D009020:Morphine / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D009020:Morphine