Urinary MHPG and clinical symptoms in patients with unipolar depression.
The relationship between levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and symptom scores on the Hamilton Rating Scale for Depression was examined in 31 patients with unipolar depression. Patients with either low MHPG or high MHPG showed significant sleep disturbance in the form of early morning awakening. Patients with mid-range or high MHPG showed decreased work and activities. Endogenomorphy factor scores represented a blend of these findings.
Department of Psychiatry, Harvard Medical School, Boston, MA.
J A
JA
Samson
S M
SM
Mirin
M
M
Griffin
D
D
Borrelli
J J
JJ
Schildkraut
D000328:Adult; D001835:Body Weight; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis / Q000652:urine; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011596:Psychomotor Disorders / Q000150:complications / Q000175:diagnosis / Q000652:urine; D012893:Sleep Wake Disorders / Q000150:complications / Q000175:diagnosis / Q000652:urine; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D008734:Methoxyhydroxyphenylglycol; D003907:Dexamethasone; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone