Systemic and pulmonary haemodynamic effects of intravenous infusion of non-ionic isoosmolar dimeric contrast media. An investigation in the pig of two ratio 6 contrast media.
The systemic and pulmonary haemodynamic effects of i.v. infusion (1 ml/s) of high doses (4 ml/kg) of 2 non-ionic, isoosmolar dimeric contrast media (CM) were investigated in 17 female pigs. The 2 CM were iodixanol and iotrolan. Both CM induced a significant increase of the following parameters: mean arterial, mean right atrial, mean pulmonary arterial, mean pulmonary arterial occlusion pressure, cardiac output, stroke volume, and diuresis. The plasma concentration of atrial natriuretic peptide was significantly increased following infusion of the 2 CM. A significant decrease was seen in the systemic and pulmonary vascular resistance.
Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.
L
L
Sørensen
O
O
Sunnegårdh
J
J
Svanegård
S
S
Lundquist
S O
SO
Hietala
D000818:Animals; D016275:Atrial Function / Q000187:drug effects; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007262:Infusions, Intravenous; D008168:Lung / Q000502:physiology; D009994:Osmolar Concentration; D011651:Pulmonary Artery; D013318:Stroke Volume / Q000187:drug effects; D013552:Swine; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects; D014783:Viscosity
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; D009320:Atrial Natriuretic Factor; C044834:iodixanol