[An experimental observation on the analgesic and antipyretic effects and toxicity of Acanthopanax giraldii Harms].
Experimental data indicate that EtOH extract of Acanthopanax giraldii (EAGH) has pronounced analgesic action and reduces not only high temperature induced by proteinic jelly, but also normal body temperature in rabbits. However no effect was observed on the fever induced by choleraic vaccine in rabbits. The acute ip LD50 of EAGH in mice was 73.34 +/- 7.29 g/kg (crude drug). In prolonged toxicity test on rats no harmful effects on body weight, blood picture, liver and kidney functions were observed.
Deng
H Z
HZ
Nanfang Hospital, Guangzhou.
Sun
S Y
SY
Li
S Y
SY
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects*; D022121:Cholera Vaccines; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D022121:Cholera Vaccines; D004365:Drugs, Chinese Herbal