Determination of oxytetracycline and its decomposition products in Tetran vulnerary powder.
A simple and fast HPLC method was developed for the determination of oxytetracycline and its decomposition products in pharmaceutical preparations. For this purpose an octadecyl modified silica stationary phase and a terner eluent containing aceto-nitrile-methanol-aqueous oxalic acid/EDTA solution was employed. Using this method, a stability study of oxytetracycline-containing powder was carried out. In this paper the analytical method and its performance data, the sample preparation and the obtained stability data are presented. The literature published on this topic is also shortly overviewed and discussed.
Morovján
G Y
GY
Technical University, Budapest.
Horváth
E
E
Vági
I
I
Fekete
J
J
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006813:Humidity; D010118:Oxytetracycline / Q000032:analysis / Q000737:chemistry*; D011208:Powders; D013696:Temperature; D013997:Time Factors
D011208:Powders; D010118:Oxytetracycline