Behavioral and biochemical effects of an ICV injection of streptozotocin in old Lewis rats.
Intracerebroventricularly (ICV) injected streptozotocin (STREP) decreases central glucose metabolism and energy metabolism, which has also been observed in patients with dementia. In the present study we examined the behavioral (open-field behavior and two-way active avoidance learning) and biochemical (hippocampal ChAT activity) effects of STREP treatment in old Lewis rats. The results suggest that hippocampal function was affected by STREP. STREP-treated rats acquired the two-way active avoidance task faster than the control rats, which indicates that STREP treatment does not lead to a general learning deficit. Hippocampal ChAT activity was decreased in STREP-treated rats. The present results suggest also that susceptibility to STREP may not be related to age in Lewis rats.
University of Limburg, Department of Neuropsychology and Psychobiology, Maastricht, The Netherlands.
A
A
Blokland
J
J
Jolles
D000375:Aging / Q000378:metabolism* / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003704:Dementia / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity*
D013311:Streptozocin; D002795:Choline O-Acetyltransferase