Effects of chronic systemic administration of 5-HT on food intake and body weight in rats.
The effects of chronic peripheral administration of 5-HT on food intake and body weight was investigated. In normal male Wistar rats, normal female Wistars, obese Zucker males, ovariectomised Wistar females, or normal Wistar males free fed a cafeteria diet, suppression of the creeping weight gain typical of control animals is observed. In females, this effect is not dependent on the local hormonal environment, because intact and ovariectomised females showed similar responses to treatment. One sex difference is that the weight suppressive effect in males is accompanied by an anorectic effect, whereas this anorectic effect is absent in females. Thus, although reduced food intake may partially explain the suppression of weight gain in males, in females it must be due to other, perhaps metabolic, effects. It is possible that these metabolic effects may also occur in males, suggesting one possible explanation of why the effect was typically larger in males than females.
Department of Psychology, University College of Swansea, Wales, UK.
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Edwards
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Stevens
D000818:Animals; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008297:Male; D009765:Obesity / Q000473:pathology / Q000503:physiopathology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D011924:Rats, Zucker; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D012727:Sex Characteristics; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D012701:Serotonin