Anticonvulsant activities of 4-bromobenzaldehyde semicarbazone.
Some of the properties of 4-bromobenzaldehyde semicarbazone (compound IV), a prototype molecule of a new class of anticonvulsants, aryl semicarbazones, are described. Compound IV demonstrated activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazol (scPTZ) tests in mice, with low neurotoxicity. When given orally to rats, it displayed high potency in the MES test and very low neurotoxicity, resulting in a high protective index (PI). Compound IV displayed no proconvulsant properties, and development of rapid tolerance was not noted. When administered intraperitoneally (i.p.) at doses of 100, 300, or 600 mg/kg to peritoneally (i.p.) at doses of 100, 300, or 600 mg/kg to rats, compound IV had no effect on levels of gamma-aminobutyric acid (GABA) or on GABA-T activity in whole brain. When tested in vitro, compound IV had no effect on rat brain GABA-T at a drug concentration of 100 microM. Although the activities of certain drug-metabolizing enzymes were increased after oral administration of compound IV to rats, these effects were less prominent than those of phenytoin (PHT) and carbamazepine (CBZ). The principal mode of action of compound IV does not appear to be an interaction with the GABAA receptor complex, and other mechanisms, involving excitatory amino acid neurotransmission, will have to be considered in future investigations of the anticonvulsant activity of this compound.
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
J R
JR
Dimmock
G B
GB
Baker
D000818:Animals; D000927:Anticonvulsants; D001547:Benzaldehydes / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D017605:Bromine Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D007696:Kindling, Neurologic / Q000187:drug effects; D010433:Pentylenetetrazole; D018079:Receptors, GABA / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012664:Semicarbazones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000927:Anticonvulsants; D001547:Benzaldehydes; D017605:Bromine Compounds; D018079:Receptors, GABA; D012664:Semicarbazones; C088211:4-bromobenzaldehyde semicarbazone; D005680:gamma-Aminobutyric Acid; D010433:Pentylenetetrazole