[The effect of pyrazidol on the catalytic properties of monoamine oxidases in pressure-chamber hypoxia in rats].
Effects of pyrasidol (1,10-trimethylen-8-methyl-1,2,3,4-tetrahydropyrasino(1,2-a) indol hydrochloride)--a selective reversible inhibitor of monoaminoxidase (MAO)--on substrate specificity of MAO fragments of mitochondrial membranes of the rat liver in altitude chamber hypoxia were studied. It is shown that pyrasidol during hypoxic exposure causes a sharp initial decrease of functional activity of type A MAO in the rat liver and its subsequent significant increase, i.e., elevates reserve potentialities of monoaminergic neuromediation which, along with a selective inhibition of oxidation of biogenic amines and activation oxidative deamination of other nitrogenous compounds, contributes to better survival rate in animals in hypoxic environment.
Zelenshchikova
V A
VA
Min'ko
Iu V
IuV
Shatemirova
K K
KK
D000818:Animals; D001273:Atmosphere Exposure Chambers; D002227:Carbazoles / Q000494:pharmacology*; D002384:Catalysis / Q000187:drug effects; D003641:Deamination / Q000187:drug effects; D000860:Hypoxia / Q000201:enzymology*; D007113:Immunity, Innate; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000187:drug effects*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013379:Substrate Specificity / Q000187:drug effects; D013997:Time Factors
D002227:Carbazoles; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; C009830:pirlindole
Vliianie pirazidola na kataliticheskie svoĭstva monoaminoksidaz v usloviiakh barokamernoĭ gipoksii u krys.