Influenza A virus replication is inhibited by tumor necrosis factor-alpha in vitro.
Treatment of Madin-Darby canine kidney (MDCK) cells with > or = 10 ng/ml of recombinant murine tumor necrosis factor-alpha (rmTNF-alpha) prior to inoculation with influenza A/PR/8/34, (H1N1), resulted in decreased production of infectious virus as determined by plaque assay, inhibition of viral protein synthesis and a reduction in cytopathic effect. The inhibition of viral replication in vitro suggests a role for TNF-alpha in the host's defense against influenza A virus infections.
Van Campen
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Department of Veterinary Science, Pennsylvania State University.
D000818:Animals; D002460:Cell Line; D004285:Dogs; D009980:Influenza A virus / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D014409:Tumor Necrosis Factor-alpha