Effects of hypolipidaemics cetaben and clofibrate on mitochondrial and peroxisomal enzymes of rat liver.
Clofibrate or cetaben was administered to male rats for 10 days. Peroxisomal and mitochondrial enzymes were assayed in liver subcellular fractions. Clofibrate affected the specific activities of both mitochondrial enzymes (glycerol-3-phosphate dehydrogenase and nicotinamide-linked isocitrate dehydrogenase) and peroxisomal enzymes (fatty acyl-CoA oxidase, glycerone phosphate acyltransferase, urate oxidase, and D-amino-acid oxidase). In contrast, cetaben raised only the peroxisomal enzymes, acyl-CoA oxidase, glycerone-phosphate acyltransferase, D-amino-acid oxidase, catalase, and urate oxidase. Thus, the hypolipidaemic activity of these drugs may be exclusively related to stimulated peroxisomal functioning, while mitochondria play only a minor role.
Schön
H J
HJ
Department of Medical Chemistry, University of Vienna, Austria.
Grgurin
M
M
Klune
G
G
Prager
C
C
Marz
R
R
Legenstein
E
E
Böck
P
P
Kramar
R
R
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008830:Microbodies / Q000187:drug effects* / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013347:Subcellular Fractions; D062366:para-Aminobenzoates
D000960:Hypolipidemic Agents; D008055:Lipids; D062366:para-Aminobenzoates; C018246:cetaben; D002994:Clofibrate; D010129:4-Aminobenzoic Acid