p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas.
OBJECTIVE
To study the expression of p53 tumour suppressor gene in anaplastic carcinomas arising from thyroid papillary carcinomas.


METHODS
Formalin fixed, paraffin wax embedded tissues from four cases of anaplastic carcinomas associated with thyroid papillary carcinomas were studied by immunohistochemistry with two different p53 monoclonal antibodies.


RESULTS
The anaplastic component showed nuclear immunostaining in two cases, but not in the other two. In all cases the papillary carcinoma component was negative.


CONCLUSIONS
The results support the hypothesis that p53 stimulates tumour progression in thyroid tumours.
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
X
X
Matias-Guiu
M
M
Cuatrecasas
E
E
Musulen
J
J
Prat
D002277:Carcinoma / Q000235:genetics; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D016159:Tumor Suppressor Protein p53