[Effect of exposure to various concentrations of dalargin on immunocompetent cells in vitro and the feasibility of its use as an immunomodulator].
Effects of various concentrations of dalargin on quantitative parameters of peripheral blood E-rosette-forming cells were studied in vitro. The drug had a stimulating effect in concentrations 10(-2)-10(-4) and 10(-12)-10(-14) micrograms/ml and an inhibiting effect in concentrations 10(-6)-10(-10) micrograms/ml. The drug had no effect in concentrations 10(-5) and 10(-11) micrograms/ml. Biphasic nature of dalargin effect permit the authors recommend it as an immunomodulating agent. The findings helped develop an individualized approach to prescription of dalargin therapy with due consideration of the initial counts of immunocompetent cells.
Mikhu
I Ia
IIa
Izachik
Iu A
IuA
Ruzhitskaia
E A
EA
Kapustin
A V
AV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Effekt vozdeĭstviia razlichnykh kontsentratsiĭ dalargina na immunokompetentnye kletki in vitro i vozmozhnosti ego ispol'zovaniia v kachestve immunomoduliruiushchego sredstva.