Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases.
The case histories are reported of two patients with systemic lupus erythematosus (SLE) who developed fatal neurological involvement, each presenting with cerebellar and brainstem signs. Neuro-pathological changes were confined to the cerebellum and brainstem, with clear evidence of a small vessel vasculopathy. The predominant histological abnormalities were multiple perivascular haemorrhages in one case and classical vasculitic changes in the other.
Department of Rheumatology, Southampton University Hospitals, Southampton General Hospital, United Kingdom.
R W
RW
Smith
D W
DW
Ellison
E A
EA
Jenkins
P J
PJ
Gallagher
M I
MI
Cawley
D000328:Adult; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000098:blood supply*; D002531:Cerebellum / Q000098:blood supply*; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology