Treponema denticola as a model for polar adhesion and cytopathogenicity of spirochetes.
Recent studies suggest that the tip-oriented adhesion of Treponema denticola is a consequence of polar clustering of its adhesins on contact with the substratum and is compatible with viability. Such adhesion to cells stimulates a host of cytoskeletal and volume regulatory changes. These studies may give insight into mechanisms of colonization and cytopathogenicity of other pathogenic spirochetes.
Ellen
R P
RP
Dept of Periodontics, Faculty of Dentistry, University of Toronto, Canada.
Dawson
J R
JR
Yang
P F
PF
D001422:Bacterial Adhesion; D006801:Humans; D008954:Models, Biological; D014208:Treponema / Q000472:pathogenicity*; D014211:Treponemal Infections / Q000382:microbiology / Q000473:pathology