[Research on hemostatic constituents in carbonized Schizonepeta tenuifolia Brig].
It has been shown that the fatsoluble extract SeE from carbonized Schizonepeta tenuifolia has an obvious hemostatic action. In a given range of dose there is a significant linear correlation between the logarithms of its doses and the reciprocal of the bleeding and coagulating times in mice. Obvious hemostatic action was observed after mice had been administered in ip and po respectively for 0.5h and 1h. The hemostatic time of the former was 6h and the latter 12h. The LD50 of StE in po was 2.652 +/- 0.286 g/kg, while in ip 1.945 4/- 0.207 g/kg.
Ding
N W
NW
Nanjing College of Traditional Chinese Medicine.
Kong
L D
LD
Wu
H
H
Wang
S L
SL
Long
Q J
QJ
Yao
Z
Z
Chen
J
J
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006490:Hemostatics / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011817:Rabbits; D014914:Whole Blood Coagulation Time
D004365:Drugs, Chinese Herbal; D006490:Hemostatics