[Surfactant interactions in model and biological membranes. IX. Theoretical model of biological activity in relation to the length of hydrocarbon chains].
A theoretical model is proposed according to which the quasi-parabolic dependence of the biological activity of amphiphilic compounds on their hydrophobic substituent chain length (the "cut-off" effect) is caused by a combination of partition equilibria and geometrical parameters of these compounds interacting with the bilayer of phospholipid membranes. The most important parameter seems to be a change in the thickness of the phospholipid bilayer. The model is quantified for the case of normal alcohols.
Katedra fyzikálnej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
J
J
Cibula
J
J
Gallová
D
D
Uhríková
P
P
Balgavý
D002462:Cell Membrane; D006838:Hydrocarbons / Q000737:chemistry*; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D008954:Models, Biological
D006838:Hydrocarbons; D008051:Lipid Bilayers; D008567:Membranes, Artificial
Interakcia surfaktantov s modelovými a biologickými membránami. IX. Teoretický model závislosti biologickej úcinnosti na dĺzke uhl'ovodíkového ret'azca.