Association between relapsing polychondritis and systemic lupus erythematosus.
Relapsing polychondritis (RP) is an autoimmune disorder with chondritis as a prominent clinical feature. This disease has been found to coexist in some patients with systemic lupus erythematosus (SLE) or vice versa. We report a patient with clinical criteria fulfilling the diagnosis of RP. She had elevated levels of anti-dsDNA and decreased levels of CH50 during the 6-month observation, without clinical manifestations of SLE except for arthritis. We also reviewed all 16 cases of previously described patients with RP and SLE. From our study, we conclude that chondritis is rare in patients with SLE. If immunologic abnormalities usually found in SLE are detected in patients with RP, clinicians should observe patients for other manifestations of SLE.
Department of Medicine, University of Mississippi Medical Center, Jackson 39216-4505.
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Harisdangkul
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Johnson
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
D000974:Antibodies, Antinuclear; D004247:DNA