Central activity of peptide Gly-Pro-Hyp--the main component of collagen degradation products mixture.
The effect of tripeptide Gly-Pro-Hyp on the central nervous system was studied. The peptide Gly-Pro-Hyp is a main component of the mixture of collagen type I degradation products obtained by 6-h digestion with bacterial collagenase. The investigated peptide in the doses 1 microgram, 2 micrograms, and 5 micrograms significantly reduces the psychomotor activity of animals, intensifies haloperidol-induced catalepsy and enhances stereotypy behaviour after apomorphine administration. The central activity of Gly-Pro-Hyp is similar to the action of collagen degradation products mixture. This suggests that this peptide may be the active substance responsible for the effects of degradation products of collagen type I.
Department of Pharmacology, Medical Academy, Białystok, Poland.
K
K
Wiśniewski
B
B
Artemowicz
A
A
Lutostańska
J
J
Maćkowiak
W
W
Koziołkiewicz
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002375:Catalepsy / Q000503:physiopathology; D003094:Collagen / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects
D009842:Oligopeptides; C088188:glycyl-prolyl-hydroxyproline; D003094:Collagen