Extra-weak chemiluminescence of drugs. XV. Method for determining stability of Toki-shakuyaku-san extract granules.
The purpose of the study was to evaluate the quality of Toki-shakuyaku-san extract granules (TJ-23) using chemiluminescence (CL). A linear relationship was obtained between the log value of the CL of TJ-23 and the reaction temperature. An excellent correlation (r = 0.999) was found between the slope of this curve (delta A) and the colour intensity due to the browning reaction occurring at the early stage of the Maillard reaction.
Sato
H
H
Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.
Hirayama
H
H
Yamamoto
T
T
Ichio
Y
Y
Ishizawa
F
F
Mizugaki
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal; D008163:Luminescent Measurements; D010946:Plants, Medicinal / Q000737:chemistry*; D011874:Radiometry / Q000379:methods; D013816:Thermodynamics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C413220:toki-shakuyaku-san