Molecular aspects of drug resistance in parasitic helminths.
Parasitic helminths (worms) cause serious infectious diseases in humans and animals. As control of these infections relies mostly on chemotherapeutics, the anthelmintics, resistance has developed against most of these drugs in several parasite species. These resistant parasites are being used to elucidate the molecular mechanisms of drug action.
Roos
M H
MH
Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Kwa
M S
MS
Veenstra
J G
JG
Kooyman
F N
FN
Boersema
J H
JH
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D006373:Helminthiasis / Q000188:drug therapy*; D006374:Helminthiasis, Animal; D006376:Helminths / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D007559:Ivermectin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D009154:Mutation; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use; D014404:Tubulin / Q000235:genetics / Q000378:metabolism
D000871:Anthelmintics; D001562:Benzimidazoles; D007093:Imidazoles; D013844:Thiazoles; D014404:Tubulin; D007559:Ivermectin; C019264:avermectin