Prognostic significance of hst-1 gene amplification in primary esophageal carcinomas and its relationship to other prognostic factors.
We studied hst-1 gene amplification in 50 primary human esophageal carcinomas using Southern blot analysis. We found 3- to 9-fold amplification of the hst-1 gene in 15 out of 50 (30.0%) DNA samples from primary tumors. There was no evidence of a correlation between hst-1 gene amplification and several prognostic factors other than the histological type; hst-1 gene amplification was more common in well differentiated squamous cell carcinoma. Survival rates for patients bearing tumors with and without hst-1 gene amplification were calculated by the Kaplan-Meier method and evaluated by the log-rank test. The survival curves for the two groups were almost identical. These results suggest that amplification of the hst-1 gene is a poor indicator of the prognosis of patients who have undergone surgery for primary esophageal carcinoma.
Department of Surgery II, Tohoku University School of Medicine, Sendai, Japan.
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Shiga
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Shiga
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Hirayama
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Katayama
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Nishihira
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Mori
D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D051519:Fibroblast Growth Factor 4; D005346:Fibroblast Growth Factors / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D011519:Proto-Oncogenes; D016019:Survival Analysis
C496445:FGF4 protein, human; D051519:Fibroblast Growth Factor 4; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors