Intracerebral hemorrhage complicating urokinase infusion into an occluded aortocoronary bypass graft.
Selective infusion of urokinase into occluded coronary bypass vein grafts is effective in restoring patency. We report the occurrence of intracerebral hemorrhage complicating an intra-graft urokinase infusion protocol. The patient had known cerebral vascular structural pathology without recent clinical complications. Caution with the use of thrombolysis in this setting is suggested.
Taylor
M A
MA
Department of Cardiology, Deborah Heart and Lung Center, Browns Mills, New Jersey 08015.
Santoian
E C
EC
Aji
J
J
Eldredge
W J
WJ
Cha
S D
SD
Dennis
C A
CA
D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D000075202:Contraindications; D001026:Coronary Artery Bypass; D006083:Graft Occlusion, Vascular / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000637:transplantation; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D014568:Urokinase-Type Plasminogen Activator