The interactions of modified lipoproteins with human erythrocyte membranes.
The interactions of native and modified lipoproteins with erythrocyte membranes were studied via electron paramagnetic resonance (EPR). The in vitro incubation of minimally oxidized and glycated low density lipoprotein (LDL) with erythrocyte membranes of normal subjects induced a slight rigidification of the membrane lipids. The glycated LDL also caused alterations in conformation of normal and diabetic erythrocyte membrane proteins. In contrast both oxidized and glycated high density lipoprotein (HDL) caused no significant changes in the organization of membranes. These, new findings suggest that the modified LDL may influence the structure of erythrocyte membrane components.
Department of Thermobiology, University of Lódź, Poland.
Z
Z
Jóźwiak
D
D
Pałecz
G
G
Bartosz
D003920:Diabetes Mellitus / Q000097:blood; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood* / Q000494:pharmacology; D008301:Maleimides; D008560:Membrane Fluidity / Q000187:drug effects; D008565:Membrane Proteins / Q000494:pharmacology; D008954:Models, Biological; D010084:Oxidation-Reduction; D017392:Thiobarbituric Acid Reactive Substances / Q000494:pharmacology
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008301:Maleimides; D008565:Membrane Proteins; D017392:Thiobarbituric Acid Reactive Substances; C043592:maleimide