Down's syndrome, Edwards' syndrome, Patau's syndrome--synthesis of glycosaminoglycans.
Synthesis of glycosaminoglycans (GAGs) by fibroblasts derived from seven patients with Down's syndrome, five patients with Edwards' syndrome, and two patients with Patau's syndrome were studied in cell culture. The aneuploid strains were compared with diploid fibroblasts from age-matched controls. In terms of hyaluronic acid and sulfated GAG synthesis, the amount of synthesized hyaluronic acid was not significantly different between postnatal aneuploid strains and controls.
Research Center of Medical Genetics RAMS, Moscow, Russia.
V
V
Kukharenko
S
S
Sheleg
M
M
Freudine
E
E
Pichugina
A
A
Delvig
D002478:Cells, Cultured; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis; D007223:Infant; D013577:Syndrome; D014314:Trisomy / Q000235:genetics
D006025:Glycosaminoglycans; D006820:Hyaluronic Acid