Heparinless cardiopulmonary bypass with ancrod.
A case is reported of a 22-year-old man with heparin-induced thrombocytopenia and thrombosis syndrome and a right atrial foreign body (Greenfield filter). Heparinless cardiopulmonary bypass for removal of the foreign body was conducted by pretreatment with ancrod, a rapid-acting antifibrinolytic of pit viper venom origin. Treatment protocol and a literature review are included in this article.
Department of Surgery, Deborah Heart and Lung Center, Browns Mills, New Jersey 08015-1799.
A H
AH
O-Yurvati
G W
GW
Laub
T J
TJ
Southgate
L B
LB
McGrath
D000328:Adult; D000721:Ancrod / Q000008:administration & dosage / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D005547:Foreign Bodies / Q000601:surgery*; D006325:Heart Atria; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008297:Male; D013577:Syndrome; D013921:Thrombocytopenia / Q000139:chemically induced; D013927:Thrombosis / Q000139:chemically induced; D016306:Vena Cava Filters / Q000009:adverse effects*
D005340:Fibrinogen; D006493:Heparin; D000721:Ancrod