Synthesis and diuretic activity of (E)-2-methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-5-carboxald ehyde dimethylaminoacetohydrazone.
(E)-2-Methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-5-carboxalde hyde dimethylaminoacetohydrazone was synthesized and its configuration determined. The diuretic activity of this compound, evaluated in rats in a dosage range of 2.5, 10 and 40 mg/kg, was higher than that of the reference compounds hydrochlorothiazide and furosemide.
Andreani
A
A
Università di Bologna, Dipartimento di Scienze Farmaceutiche, Italy.
Rambaldi
M
M
Locatelli
A
A
Malandrino
S
S
Pifferi
G
G
D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D004573:Electrolytes / Q000652:urine; D005665:Furosemide / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D006852:Hydrochlorothiazide / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D004232:Diuretics; D004573:Electrolytes; D006835:Hydrazones; D013830:Thiadiazoles; D006852:Hydrochlorothiazide; C088091:2-methyl-6-phenylimidazo(2,1-b)-1,3,4-thiadiazole-5-carboxaldehyde dimethylaminoacetohydrazone; D005665:Furosemide