Amino acids and peptides. XX. Preparation of beta-cyclododecyl aspartate and its application to synthesis of fibronectin- and laminin-related peptides.
beta-Cyclododecyl aspartate was prepared and its application to peptide synthesis was examined. Derivatives of beta-cyclododecyl aspartate are more likely to crystallize and should be useful for peptide synthesis. The cyclododecyl ester was much stable to bases than the benzyl ester and rather more stable than the cyclohexyl ester. It was removable by HF treatment and trifluoromethanesulfonic acid treatment. beta-Cyclododecyl aspartate was used for synthesis of laminin- and fibronectin-related peptides by solid phase and liquid phase methods.
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
K
K
Kawasaki
T
T
Murakami
K
K
Koshino
M
M
Namikawa
M
M
Maeda
T
T
Hama
T
T
Mayumi
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005353:Fibronectins / Q000138:chemical synthesis*; D007797:Laminin / Q000737:chemistry*; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*
D000596:Amino Acids; D005353:Fibronectins; D007797:Laminin; D010446:Peptide Fragments; D010455:Peptides; C088122:beta-cyclododecyl aspartate; D001224:Aspartic Acid