[Effect of propofol on oxygenation and the pulmonary short-circuit during single-lung ventilation].
OBJECTIVE
To determine the effect of propofol on pulmonary short circuit or shunt (Qs/Qt).


METHODS
Nine patients undergoing scheduled thoracic surgery with single lung ventilation were studied. All patients were anesthesized with 2 mg/kg propofol followed by a continuous infusion of 4-6 mg/kg/h; fentanyl 0.3 mg followed by bolus as needed; and relaxed with atracurium 0.5 mg/kg followed by bolus of 0.1-0.2 mg/kg as needed. The ratio Qs/Qt was calculated with an FiO2 of 1 and patients in lateral decubitus.


RESULTS
During double-lung ventilation Qs/Qt was 17.4 +/- 5.4% and PO2 was 430 +/- 16 mmHg, while shunt increased to 27.8 +/- 8.4% and PO2 decreased to 258 +/- 127 mmHg during single-lung ventilation. Change was significant in both cases.


CONCLUSIONS
Continuous infusion of propofol produces a significant increase of Qs/Qt and a significant decrease of PaO2 during single-lung ventilation for thoracic surgery.
Servicio de Anestesiología y Reanimación, Hospital Puerta del Mar, SAS, Cádiz.
J A
JA
Pueyo
A
A
Pajuelo
R
R
Fuentes
A
A
Bustos
M
M
Guerrero
M
M
Muñoz
D000328:Adult; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000209:etiology*; D007431:Intraoperative Complications / Q000097:blood / Q000209:etiology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D015742:Propofol / Q000009:adverse effects* / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D013908:Thoracotomy; D014661:Vasoconstriction / Q000187:drug effects; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects*
D010100:Oxygen; D015742:Propofol
Efecto del propofol sobre la oxigenación y el cortocircuito pulmonar durante la ventilación a un solo pulmón.