[The age-related characteristics of the dopaminergic regulation of prolactin secretion in men].
Age-specific time course of prolactin secretion and features of dopaminergic regulation of this hormone secretion were studied in boys aged 3 to 15 and in adult men aged 20 to 25. Blood plasma prolactin concentration was found reduced in boys, and this hormone level, characteristic for adults, sets up at the age of 9-11. Dopaminergic regulation of prolactin secretion undergoes three stages in boys: Stage 1--hyperreaction to introduction of a receptor antagonist at the age of 3 to 8, Stage 2--at the age of 9 to 11--reduced reaction to D2 receptor blocking, though this reaction being much higher than in adults, and Stage 3 (at the age of 12-15)--development of a normal reaction characteristic of adults.
Gubernatorov
E E
EE
Gerasimov
G A
GA
Bershinskiĭ
V P
VP
Pivovarov
S A
SA
Orlov
K V
KV
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood* / Q000187:drug effects; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008787:Metoclopramide; D011388:Prolactin / Q000097:blood / Q000187:drug effects / Q000378:metabolism*; D011863:Radioimmunoassay; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values
D011954:Receptors, Dopamine; D011388:Prolactin; D008787:Metoclopramide
Vozrastnye osobennosti dofaminergicheskoĭ reguliatsii sekretsii prolaktina u muzhchin.