Interferon-activated signal transduction to the nucleus.
Recent studies on gene activation by interferons have uncovered a direct signaling pathway from the cell-surface receptor for interferons to the nucleus. Activation of JAK tyrosine kinases by interferons leads to activation, by direct tyrosine phosphorylation, of a family of latent cytoplasmic transcription factors named STATs (for signal transducers and activators of transcription), which then translocate to the nucleus to direct transcriptional activation.
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
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D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology*; D008969:Molecular Sequence Data; D015398:Signal Transduction; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D007370:Interferon Type I; D007371:Interferon-gamma