The total peroxyl radical-trapping ability of plasma and cerebrospinal fluid in normal and preeclamptic parturients.
Plasma and cerebrospinal fluid total peroxyl radical-trapping antioxidative parameter (TRAP) and the main antioxidant components of TRAP (vitamin E, ascorbic acid, uric acid, protein sulfhydryl groups, and the unidentified antioxidant proportion) were analyzed in 11 preeclamptic parturients, 9 healthy parturients with an uncomplicated pregnancy, and 10 healthy nonpregnant women. In addition, the possible effects of ongoing labor were studied in 10 healthy parturients. The samples of plasma and cerebrospinal fluid (CSF) were collected at cesarean section (pregnant women) or minor surgical procedure (nonpregnant women). Normal pregnancy or ongoing labor induced no significant changes in total TRAP, as compared with nonpregnant women, but significant changes in the percentage contributions of individual antioxidants were noted in plasma and CSF. In preeclampsia, a significant increase in TRAP was noted in both plasma and CSF. This increase was mainly due to an increased proportion of uric acid and unidentified antioxidants in plasma samples, and an increased proportion of unidentified antioxidants in CSF. The concentration of CSF ascorbic acid was decreased in preeclampsia, and a negative correlation between CSF ascorbic acid and blood pressure was observed.
Department of Gynecology and Obstetrics, Tampere University, Finland.
J T
JT
Uotila
A L
AL
Kirkkola
M
M
Rorarius
R J
RJ
Tuimala
T
T
Metsä-Ketelä
D000975:Antioxidants; D001205:Ascorbic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood / Q000134:cerebrospinal fluid; D010545:Peroxides / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood* / Q000134:cerebrospinal fluid*; D011247:Pregnancy; D013438:Sulfhydryl Compounds / Q000097:blood / Q000134:cerebrospinal fluid; D014527:Uric Acid / Q000097:blood / Q000134:cerebrospinal fluid; D014810:Vitamin E / Q000097:blood / Q000134:cerebrospinal fluid
D000975:Antioxidants; D010545:Peroxides; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D014527:Uric Acid; C049375:perhydroxyl radical; D001205:Ascorbic Acid