Facial erythema and pigmentation as an initial manifestation of chronic graft-versus-host disease.
Two bone marrow transplant recipients developed chronic graft-versus-host disease, presenting with a mild erythematous, pigmented eruption only on the face three and ten months after transplantation. Histologically, the lesions showed liquefaction degeneration of basal keratinocytes and incontinence of melanin in the upper dermis with a mild infiltrate of T-lymphocytes. These findings suggest that such a facial eruption occasionally may represent an initial manifestation of chronic GVHD.
Department of Dermatology, Hamamatsu University School of Medicine, Japan.
Y
Y
Tokura
H
H
Yagi
K
K
Iwasaki
M
M
Takigawa
D000293:Adolescent; D016026:Bone Marrow Transplantation; D002648:Child; D002908:Chronic Disease; D004890:Erythema / Q000209:etiology* / Q000473:pathology; D005145:Face; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D008297:Male; D010859:Pigmentation Disorders / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology*