[Immunocytophotometric and cytogenetic analyses of T-lymphoblastoid cell lines in experimental HIV Infection].
The accumulation of viral proteins p24 and gp41 in MT-4 cells was shown to occur asynchronously. No increase in the number of polydiploid cells, no polyploid mitoses or chromosome defects were found indicating the antiproliferative effect of HIV on MT-4 cells. A cyclic pattern of the infection course was observed in infected Jurkat-tat cells. The accumulation of viral proteins was concerted, their maximum amounts preceding the cell death. HIV-1 did not inhibit cell division and caused strong disorders in the chromosome structure.
A A
AA
Kushch
E P
EP
Shumaĭ
L A
LA
Glukhova
Iu A
IuA
Magakin
A S
AS
Avetisian
A M
AM
Kapantsian
E M
EM
Karalova
I L
IL
Grabovskaia
D000208:Acute Disease; D002460:Cell Line; D002478:Cells, Cultured / Q000378:metabolism / Q000382:microbiology; D002869:Chromosome Aberrations; D003588:Cytopathogenic Effect, Viral; D003592:Cytophotometry; D016655:HIV Core Protein p24 / Q000378:metabolism; D015700:HIV Envelope Protein gp41 / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism / Q000382:microbiology*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D007150:Immunohistochemistry; D011123:Polyploidy; D013601:T-Lymphocytes / Q000378:metabolism / Q000382:microbiology*; D013997:Time Factors
D016655:HIV Core Protein p24; D015700:HIV Envelope Protein gp41
Immunotsitofotometricheskiĭ i tsitogeneticheskiĭ analiz kletok T-limfoblastoidnykh liniĭ pri éksperimental'noĭ VICh-infektsii.