Pressure-induced contraction of the juxtamedullary afferent arterioles in spontaneously hypertensive rats.
1. In the SHR juxtamedullary nephron preparation, the increase of the perfusion pressure from 80 to 160 mmHg increased the diameters of arcuate arteries but produced a pressure-dependent contraction of the afferent arterioles, a response that can account for renal autoregulation. 2. The pressure-induced contractions of the afferent arterioles were abolished by 1 microM nifedipine and by 10 microM furosemide, suggesting that the autoregulatory responses are mainly mediated by tubuloglomerular mechanisms and can be abolished by calcium antagonists.
Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.
R
R
González
M S
MS
Fernández-Alfonso
M A
MA
Rodríguez-Martinez
E
E
Fuertes
J
J
Angulo
C F
CF
Sánchez-Ferrer
J
J
Marín
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005665:Furosemide / Q000494:pharmacology; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000098:blood supply* / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009399:Nephrons / Q000098:blood supply / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion; D011312:Pressure; D051381:Rats; D011918:Rats, Inbred SHR; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D005665:Furosemide; D009543:Nifedipine; D009638:Norepinephrine