Effect of pentoxifylline, a multidrug resistance reversal agent, on haemopoietic stem cell homing.
This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerizing agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing receptor is anchored to cytoskeletal support intracellularly.
Gude
R P
RP
Chemotherapy and Stem Cell Biology Division, Cancer Research Institute, Parel, Bombay, India.
Chitnis
M P
MP
Rao
S G
SG
D000818:Animals; D001854:Bone Marrow Cells; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010431:Pentoxifylline / Q000494:pharmacology* / Q000633:toxicity; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000166:cytology
D010431:Pentoxifylline