Lectin effects on HIV-1 infectivity.
Lectins with specificity for terminal mannose residues and anti-mannan antibodies are assumed to neutralize HIV-1 by binding to the viral glycoproteins. In this report we demonstrate that one such agents, the lectin from Galanthus nivalis (GNA), blocks infection also at the target cell level.
Hammar
L
L
Department of Veterinary Virology, Biomedical Center, Uppsala, Sweden.
Hirsch
I
I
Machado
A
A
De Mareuil
J
J
Baillon
J
J
Chermann
J C
JC
D002240:Carbohydrate Sequence; D002478:Cells, Cultured; D027801:Galanthus; D015726:Giant Cells / Q000382:microbiology; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D037102:Lectins / Q000494:pharmacology*; D037241:Mannose-Binding Lectins; D008969:Molecular Sequence Data; D037121:Plant Lectins; D014774:Virulence / Q000187:drug effects
D015699:HIV Envelope Protein gp120; D037102:Lectins; D037241:Mannose-Binding Lectins; D037121:Plant Lectins; C063117:snowdrop lectin