Treponema denticola as a model for polar adhesion and cytopathogenicity of spirochetes.
Recent studies suggest that the tip-oriented adhesion of Treponema denticola is a consequence of polar clustering of its adhesins on contact with the substratum and is compatible with viability. Such adhesion to cells stimulates a host of cytoskeletal and volume regulatory changes. These studies may give insight into mechanisms of colonization and cytopathogenicity of other pathogenic spirochetes.
Dept of Periodontics, Faculty of Dentistry, University of Toronto, Canada.
R P
RP
Ellen
J R
JR
Dawson
P F
PF
Yang
D001422:Bacterial Adhesion; D006801:Humans; D008954:Models, Biological; D014208:Treponema / Q000472:pathogenicity*; D014211:Treponemal Infections / Q000382:microbiology / Q000473:pathology