The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3.
The human and murine chromosomal localization for the gene for the retinal pigment epithelium-specific protein RPE65 was determined. Using interspecific backcross analysis, we mapped Rpe65 to the distal end of mouse chromosome 3. In the human, using a human-hamster hybrid panel, RPE65 was mapped to chromosome 1. By the use of fluorescence in situ hybridization, this localization was refined to 1p31. The mouse and human loci for this potential candidate gene for hereditary retinal disease do not match those of any known disease in mouse or man.
Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
C P
CP
Hamel
N A
NA
Jenkins
D J
DJ
Gilbert
N G
NG
Copeland
T M
TM
Redmond
D000818:Animals; D002352:Carrier Proteins; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006224:Cricetinae; D005136:Eye Proteins / Q000235:genetics*; D005819:Genetic Markers; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics*; D010857:Pigment Epithelium of Eye / Q000378:metabolism*; D011506:Proteins; D012164:Retinal Diseases / Q000235:genetics; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase
D002352:Carrier Proteins; D005136:Eye Proteins; D005819:Genetic Markers; D011506:Proteins; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase