Electrocardiographic findings in Rett syndrome: an explanation for sudden death?
Girls with Rett syndrome had significantly longer corrected QT intervals (p < 0.001) and more T-wave abnormalities (p < 0.001) than were found in age-matched healthy girls. With advancing stages of the syndrome, the proportion of corrected QT interval prolongations and T-wave changes increased. The findings suggest a possible cardiac basis for sudden, unexpected death in Rett syndrome.
Sekul
E A
EA
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Moak
J P
JP
Schultz
R J
RJ
Glaze
D G
DG
Dunn
J K
JK
Percy
A K
AK
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003645:Death, Sudden / Q000209:etiology*; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis; D006801:Humans; D015518:Rett Syndrome / Q000150:complications / Q000503:physiopathology*