Antihypertensive property and renal protection by shichimotsu-koka-to extract in salt-induced hypertension in Dahl strain rats.
We determined whether or not the kampo formula, Shichimotsu-koka-to extract, attenuates the development of salt-induced hypertension and provides renal protection against hypertensive injury in Dahl salt-sensitive (Dahl S) rats. A six-week treatment using this formula dose-dependently decreased the systolic blood pressure in Dahl S rats fed a high-salt (2% NaCl) diet. This blood pressure reduction was associated with a decrease in the thickness of the aortic wall. Renal function was not altered with this treatment; however, glomerular sclerotic lesions in the kidney were significantly attenuated. Neither arterial nor tubular lesions were affected. These data suggest that Shichimotsukoka-to extract exhibits an antihypertensive effect which is associated with partial resolution of glomerular sclerosis in the kidney.
2nd Department of Medicine, University of Tokyo, Japan.
N
N
Hiwara
Y
Y
Uehara
S
S
Takada
Y
Y
Kawabata
N
N
Ohshima
T
T
Nagata
T
T
Ishimitsu
T
T
Gomi
A
A
Goto
T
T
Ikeda
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary; D014563:Urodynamics / Q000187:drug effects
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012982:Sodium, Dietary; D012964:Sodium