Temperature high sensitivity of manganese uptake in ileal longitudinal smooth muscle of guinea-pig.
1. Mn2+ (5 mM) inhibited completely the K+ (60 mM)-induced ileal tonic tension to the base line, however, the tension increased progressively to the above level of the original K+ tonic response after 3 hr of the Mn2+ application at 37 degrees C. 2. At 30, 32 or 34 degrees C, the tensions which developed after 3 hr of the addition of 5 mM Mn2+ in the high-K+ medium was 0, 21, 48% of their original K+ tonic levels, respectively. 3. The tension development and manganese uptake in the presence of Mn2+ in the high-K+ medium was highly dependent on the temperature in very narrow range of 32-37 degrees C in the suspending medium.
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
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Nasu
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Murase
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Shibata
D000818:Animals; D005711:Gallopamil / Q000494:pharmacology; D006168:Guinea Pigs; D006982:Hypertonic Solutions; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008345:Manganese / Q000378:metabolism* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013696:Temperature
D006982:Hypertonic Solutions; D005711:Gallopamil; D008345:Manganese; D011188:Potassium