[A comparative study of the reactions of the peripheral blood neutrophils from donors and from lymphogranulomatosis patients to arachidonate stimulation of the cells].
Arachidonate-induced aggregation and generalization of active oxygen forms (OAF) by peripheral blood neutrophils in donors were studied in donors and Hodgkin's disease patients. Leukocytes of the latter had incomplete ability to produce AOF in response to cell stimulation with arachidonic acid. The study of arachidonate-induced aggregation of neutrophils indicated no differences in the speed of the process in the patients and donors. AOF catchers did not act on the rate of leukocyte aggregation in the patients though accelerated the process in the donors. It is inferred that Hodgkin's disease is associated with dysfunction of oxygen activation by neutrophils. The findings suggest that defects in leukocytes ability to activate oxygen in Hodgkin's disease may entail deranged regulation of other processes essential for functional activity of polymorphonuclear leukocytes.
Zorin
V P
VP
Pogirnitskaia
A V
AV
Semenkova
G N
GN
Cherenkevich
S N
SN
Krutilina
N I
NI
Muravskaia
G V
GV
D000328:Adult; D016718:Arachidonic Acid / Q000494:pharmacology*; D001782:Blood Donors; D002449:Cell Aggregation / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002908:Chronic Disease; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D008163:Luminescent Measurements; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000097:blood
D016718:Arachidonic Acid; D010100:Oxygen
Sravnitel'noe issledovanie reaktsiĭ neĭtrofilov perifericheskoĭ krovi donorov i bol'nykh limfogranulematozom pri stimuliatsii kletok arakhidonatom.