Accumulation and intracellular fate of tellurite in tellurite-resistant Escherichia coli: a model for the mechanism of resistance.
The tellurite accumulation properties of three Escherichia coli strains containing different tellurium-resistance determinants of Gram-negative origin, from plasmids pMER610, pHH1508a and RK2, were compared. In all three cases membrane-associated tellurium crystallization was observed, and neither reduced uptake nor increased export contributed to the resistance. Specific membrane-proximal reduction is proposed as the mechanism of resistance to tellurite coded by all three determinants, despite their lack of sequence homology.
Lloyd-Jones
G
G
Department of Genetics and Microbiology, Donnan Laboratories, University of Liverpool, UK.
Osborn
A M
AM
Ritchie
D A
DA
Strike
P
P
Hobman
J L
JL
Brown
N L
NL
Rouch
D A
DA
D003460:Crystallization; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D008954:Models, Biological; D010084:Oxidation-Reduction; D010957:Plasmids / Q000235:genetics; D013691:Tellurium / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
C016774:tellurium dioxide; D013691:Tellurium