Central neurocytomas of the cervical spinal cord. Report of two cases.
Central neurocytoma is a neuronal neoplasm that occurs supratentorially in the lateral or third ventricles. The authors report the clinical, neuroradiological, and neuropathological features of two neurocytomas arising in the spinal cord of two men, aged 65 and 49 years. The patients presented with progressive neurological deficits referable to the cervical spinal cord. Magnetic resonance imaging revealed isodense intramedullary spinal cord tumors at the C3-4 level. Both tumors were initially misdiagnosed as gliomas. In Case 1 the correct diagnosis was made after electron microscopy revealed neuronal features. Immunostaining in Case 2 revealed that tumor cells were positive for synaptophysin and negative for glial fibrillary acidic protein, strongly indicating a neuronal tumor. It is suggested that this spinal cord neoplasm be included under the designation "central neurocytoma."
Neurosurgical Service, Massachusetts General Hospital, Boston.
S B
SB
Tatter
L F
LF
Borges
D N
DN
Louis
D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002574:Cervical Vertebrae; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000473:pathology; D005910:Glioma / Q000473:pathology; D006801:Humans; D008297:Male; D008870:Microtubules / Q000648:ultrastructure; D008875:Middle Aged; D018306:Neurocytoma / Q000473:pathology*; D009837:Oligodendroglioma / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000473:pathology*