Aspergillosis infection in neurosurgical practice.
Fungal infections including those due to aspergillus are rare in neurosurgical practice despite their possible inclusion in many differential diagnoses. Recently, these diseases have been diagnosed with increasing frequency, principally as opportunistic infections in patients undergoing treatment for diseases resulting in immune compromise. The epidemiology is poorly understood as mycoses are not notifiable diseases. We have recently been involved in the care of seven patients with aspergillosis between 1988 and 1991. Its presentation, with abscess formation, granulomas, the rhinocerebral form, meningitis, hydrocephalus and vascular involvement, is varied. The majority of cases were seen in immunocompromised patients following haematogenous dissemination from a pulmonary or gastro-intestinal focus. Direct spread from sinus infection has also been seen. The prognosis is poor despite modern antifungal treatment, which in part reflects the primary underlying condition.
Department of Neurosurgery, Atkinson Morley's Hospital, London, UK.
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Casey
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Wilkins
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Uttley
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001231:Aspergillus flavus; D001232:Aspergillus fumigatus; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D015299:Discitis / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D016921:Meningitis, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D008875:Middle Aged; D009460:Neurologic Examination; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D017287:Ventriculoperitoneal Shunt
D000935:Antifungal Agents