Fibrin sealant in laparoscopic adhesion prevention in the rabbit uterine horn model.
OBJECTIVE
To assess the effects of fibrin sealant on adhesions after laparoscopic surgery.


METHODS
Standardized surgical trauma was induced in 60 female rabbits. The animals were randomized in three groups for different adhesion prevention treatment.


METHODS
University research laboratory.


METHODS
After standardized trauma was induced, group 1 (n = 20) received no treatment, group 2 animals (n = 20) were injected in the abdominal cavity with 60 mL of Ringer's lactate, and human fibrin sealant was applied on the surgical lesions under laparoscopic vision in group 3 (n = 20).


METHODS
Five weeks after laparoscopy, a laparotomy was performed, and the adhesions were scored.


RESULTS
Fourteen of 20 rabbits in the control group (70%) presented postoperative adhesions, 11 of 20 (55%) in the Ringer's group, and 5 of 20 (25%) in the fibrin sealant group. High-score adhesions were seen in 15% of cases in control and Ringer's group and in 5% of cases in the fibrin sealant group.


CONCLUSIONS
When used during laparoscopic surgery, fibrin sealant has a preventive effect on de novo postsurgical adhesions. To assess the efficacy in reproductive surgery, a trial on recurrent postsurgical adhesions is required.
De Iaco
P
P
S. Orsola Hospital, University of Bologna, Italy.
Costa
A
A
Mazzoleni
G
G
Pasquinelli
G
G
Bassein
L
L
Marabini
A
A
D000818:Animals; D005260:Female; D015718:Fibrin Tissue Adhesive; D007552:Isotonic Solutions / Q000627:therapeutic use; D010535:Laparoscopy; D007813:Laparotomy; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D012086:Reoperation; D000077325:Ringer's Lactate; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*
D015718:Fibrin Tissue Adhesive; D007552:Isotonic Solutions; D000077325:Ringer's Lactate