Changes in energy metabolites, cGMP and intracellular pH during cortical spreading depression.
The spatial and temporal distribution of cerebral metabolites and pHi were examined in the cortex during spreading depression. Acidification and marked depression in the energy status of the tissue was evident at the wavefront of spreading depression. In its aftermath, the residual activation of glycolysis and accumulation of cGMP persisted for minutes after a relatively rapid restoration of high-energy phosphates and pHi.
Laboratory of Experimental Neurological Surgery, University Hospitals of Cleveland, OH.
L M
LM
Gault
C W
CW
Lin
J C
JC
LaManna
W D
WD
Lust
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D013181:Cortical Spreading Depression / Q000502:physiology*; D006152:Cyclic GMP / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006152:Cyclic GMP