The effect of prostaglandins E2 and F2a on brain and tracheal ciliary activity.
Prostaglandins E2 and F2a have a mild stimulatory effect (+11% to 18% from baseline) on the in vitro ciliary beat frequency in tracheal rings, which contain mucus-producing cells, and in brain slices, which are devoid of mucus. Results are compared with previous studies and the merits of the used experimental models are discussed.
Department of Otorhinolaryngology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Y
Y
Roth
J
J
Kronenberg
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D006224:Cricetinae; D015237:Dinoprost / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009079:Mucociliary Clearance / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D015237:Dinoprost; D015232:Dinoprostone