Effect of vasopressin analog [d(CH2)1(5),Tyr(Me)2]AVP on learning and memory in rats chronically treated with ethanol.
The effect of single 2 micrograms dose of vasopressin (AVP) and analog [d(CH2)1(5),Tyr(Me)2]AVP on processes of retrieval, acquisition and consolidation of conditioned reflexes in rats chronically alcoholized was studied. Long term (9 weeks) ethanol intoxication profoundly impaired learning and memory processes in all tests used. The AVP analog [d(CH2)1(5), Tyr(Me)2]AVP facilitated retrieval of passive avoidance, improved consolidation of active avoidance of rats previously treated with alcohol, but did not affect the acquisition of active avoidance. [d(CH2)1(5), Tyr(Me)2]AVP did not affect the motor and exploratory activity of rats in open field.
Department of Pharmacology, Medical Academy, Białystok, Poland.
H
H
Car
M H
MH
Borawska
K
K
Wiśniewski
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D001127:Arginine Vasopressin; D000431:Ethanol; C025043:vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-