[Analysis of the behavior of rats in the Morris water-basin: new methodology and pharmacological application].
The Morris water-maze has been designed to test spatial orientation ability, learning and memory processes. In order to improve the analyse of the organization of the trajectory of rats, during the training phase, a computer program was elaborated. The study of the effect of a benzodiazepine, diazepam, was chosen to illustrate and validate this methodological approach. Results showed that rats pre-treated with diazepam (2 mg/kg) presented an impairment of spatial learning associated with the occurrence of a stereotyped circular swimming behaviour.
Anglade
F
F
ETCA, Centre d'Etudes du Bouchet, Laboratoire de Pharmacologie du Comportement, Vert-le-Petit, France.
Christin
D
D
Marchaland
C
C
Trouiller
G
G
Baudoin
C
C
Chapouthier
G
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000009:adverse effects*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D009949:Orientation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013037:Spatial Behavior / Q000187:drug effects*; D013550:Swimming; D013551:Swimming Pools
D003975:Diazepam
Analyse du comportement du rat dans la piscine de Morris: nouvelle méthodologie et application pharmacologique.