[Lyme disease in the province of Soria: clinico-epidemiologic study].
BACKGROUND
To determine the prevalence of the Borrelia burgdorferi infection in the Soria Province, and the detection of the human disease cases.


METHODS
By an indirect immunofluorescence technique, we had studied total antibodies (IgG, IgM and IgA) against B. burgdorferi (B 31 strain) in the sera of 298 people (150 men y 148 women) of the Soria Province. The results were considered positive when the titers were same or upper to 1/256. All positive sera were tested for specific IgM antibodies by same method; IgM results were considered positive when the titers were upper to 1/16.


RESULTS
13.1% of the people had positive results (39 sera): 14 for women (9.5%) and 25 for men (16.7%). We detected 14 sera with positive IgM. We demonstrated titers same or upper to 1/256 in all age group, with a major prevalence in the age group between 41 and 50 years (22.6%). In all areas of the Province we detected positive results and in many of this areas the positivity was upper to 30% of the studied sera. 12 persons with positive IgM or high titers of total antibodies presented signs or symptoms of disease in relation with B. burgdorferi infection; 6 persons had alterations of the liver function do not explicable by other etiology.


CONCLUSIONS
The B. burgdorferi infection present a high prevalence in this Province and a wide geographic distribution, with high endemic areas. We demonstrated patients with symptomatology compatible with Lyme borreliosis, and we wish to emphasize the frequency of alterations of the liver function in this group of people.
Departamento de Microbiología y Parasitología, Facultad de Medicina, Alcalá de Henares, Madrid.
J V
JV
Saz
S
S
Nuncio
F J
FJ
Merino
M
M
Aquise
J
J
Medina
A R
AR
Filipe
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood*; D008193:Lyme Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012424:Rural Population; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology
D000907:Antibodies, Bacterial; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M
Enfermedad de Lyme en la provincia de Soria: estudio clinicoepidemiológico.