Preparation and properties of buserelin suspensions.
Obtaining and some properties of suspensions with buserelin-there were obtained buserelin suspensions with zinc ions with pH 7.2-7.5 and hormone: zinc molar ratio from 1:2.5 to 1:500. The obtained buserelin suspensions show moderated hormone release in vitro and prolonged action in vivo. The pulsating buserelin release from suspensions has been found in vitro and in vivo.
Department of Applied Pharmacy and Drug Technology Medical Silesian Academy, Sosnowiec, Poland.
F
F
Ryszka
B
B
Dolińska
B
B
Szulc
G
G
Zientarska
D000818:Animals; D002064:Buserelin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007273:Injections, Intramuscular; D013535:Suspensions; D013552:Swine
D013535:Suspensions; D002064:Buserelin