Complement activation on the nasal mucosal surface--a feature of the immediate allergic reaction in the nose.
Complement is a system of functionally linked serum proteins that interact to exert biologic effects in inflammatory and immunologic processes. As part of a larger study with a potential topical antiallergic drug, we measured C3a des Arg and C5a des Arg in 13 patients with seasonal allergic rhinitis and in five nonatopic controls after placebo treatment. After 1 week of placebo treatment, a nasal allergen challenge with increasing doses of pollens was performed in both allergic subjects and controls. A symptom score method was used, and in returned nasal lavage fluid, the activity of C3a des Arg and C5a des Arg was measured. We found that allergen challenge in the allergic subjects induced nasal symptoms concomitantly with increased levels of C3a des Arg and C5a des Arg (P < 0.05). No increases either in symptoms or in the very low base-line levels of C3a des Arg and C5a des Arg were observed in the nonallergic controls. We conclude that the activation of the complement cascade is one part of the vasculature exudative response during the immediate allergic reaction in the upper airways. Because of their biologic potency, these proteins may be an essential part of the exudative response which perpetuates the ongoing inflammatory reaction.
Department of Otorhinolaryngology, University Hospital, Lund, Sweden.
M
M
Andersson
L
L
Michel
J B
JB
Llull
U
U
Pipkorn
D000328:Adult; D000485:Allergens / Q000008:administration & dosage; D003167:Complement Activation; D015926:Complement C3a / Q000031:analogs & derivatives / Q000032:analysis; D015937:Complement C5a, des-Arginine / Q000032:analysis; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology*; D010919:Placebos; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
D000485:Allergens; D015937:Complement C5a, des-Arginine; D010919:Placebos; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a