[Esters of naproxen as potential prodrugs for skin penetration. 1. Synthesis and physico-chemical properties].
Several esters of the nonsteroidal antiinflammatory drug Naproxen [2-(6-methoxy-2-naphthyl)propionic acid] were synthesized by standard procedures. Melting points and enthalpies of melting were obtained by differential scanning calorimetry. Solubilities in water were measured using HPLC. The partition coefficients (octanol/water) were calculated according to Rekker and Mannhold and Rm-values were determined by RP-TLC. The two latter parameters were correlated with high significance.
Institut für Pharmazeutische Chemie, Heinrich-Heine-Universität Düsseldorf.
H
H
Weber
K
K
Meyer-Trümpener
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009288:Naproxen / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D012869:Skin Absorption
D011355:Prodrugs; D009288:Naproxen
Ester des Naproxens als potentielle Prodrugs zur Hautpenetration, 1. Mitt.: Synthese und physikochemische Eigenschaften.