Multicentric giant cell tumor: report of five new cases.
The typical giant cell tumor (GCT) is a solitary neoplams that occurs in the epiphysis or epimetaphysis of long bones. GCT is seen with a slightly increased frequency in females, and 70% of patients are between 20 and 40 years of age at the time of presentation. Multicentric giant cell tumor (MGCT; two or more centers) is an unusual variant of GCT. Patients with MGCT are likely to be younger than those with a solitary lesion. The multicentric variety is often of a higher stage at diagnosis and is more often associated with a pathological fracture than the unifocal tumor. We are reporting five new cases of MGCT, with a total of 21 tumors seen over a period of 25 years from 1967 to 1992.
Hindman
B W
BW
Radiological Services, Orthopaedic Hospital, Los Angeles, California.
Seeger
L L
LL
Stanley
P
P
Forrester
D M
DM
Schwinn
C P
CP
Tan
S Z
SZ
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D002111:Calcaneus / Q000473:pathology; D002648:Child; D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology; D005360:Fibula / Q000473:pathology; D005385:Fingers / Q000473:pathology; D018212:Giant Cell Tumor of Bone / Q000473:pathology*; D006801:Humans; D006811:Humerus / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010384:Pelvic Bones / Q000473:pathology; D011884:Radius / Q000473:pathology; D013977:Tibia / Q000473:pathology