[The morphoimmunological correlates in the leukemic degeneration of prolymphocytic lymphosarcoma].
Morphocytochemical and immunologic features of the bone marrow and peripheral blood lymphoid elements were studied in 40 patients with B-prolymphocytic lymphosarcoma in the stage of leukemic degeneration. Four types of pathologic lymphoid cells were distinguished: large prolymphocytes expressing pan-B CD19 and HLA-Dr antigens, medium-sized prolymphocytes with round nuclei, characterized by activation CD38 and CD45Ra antigens, prolymphocytes with split nuclei containing light and heavy immunoglobulin chains, and leukemic lymphocytes containing, besides pan-B antigens and immunoglobulins, antigens of the early hemopoietic (CD34) and early B-(CD10) precursors. The content of the RAS-positive substance in the prolymphocytes was inversely proportional to the parameters of activation antigens expression. Acid phosphatase activity correlated with the expression of CD22 and CD45Ra antigens.
M A
MA
Frenkel'
T E
TE
Sokirka
N B
NB
Lebedeva
N N
NN
Tupitsyn
A Iu
AIu
Baryshnikov
E A
EA
Solov'eva
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D017254:Leukemic Infiltration / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D010641:Phenotype
D015703:Antigens, CD; D006684:HLA-DR Antigens
Morfoimmunologicheskie korreliatsii pri leĭkemizatsii prolimfotsitarnoĭ limfosarkomy.