Molecular biology and genetics of epithelial ovarian cancer.
The majority of epithelial ovarian neoplasms occur in the absence of a familial or heritable component. Relatively little is known about the molecular genetic mechanisms that contribute to the development and progression of epithelial ovarian cancer. Although historically there have been difficulties encountered in basic science investigations, many key observations have been made during the past 5 years concerning the genetic alterations associated with this disease.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas-Houston Medical School.
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Baker
D005260:Female; D006801:Humans; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes / Q000235:genetics