[Creation of diet-dependent cancer models in transgenic animals].
We have created transgenic mice lines in which SV40 T and c-myc expression was controlled by the L-pyruvate kinase gene regulatory region which is responsible for hepatic and pancreatic expression specificity, and strong dependence of this expression upon the carbohydrate composition of the diet. Models of hepatoma and endocrine pancreatic tumors have been obtained. Both tumors were dependent upon the diet, since carbohydrates strongly increased frequency and precocity of both hepatic and pancreatic carcinomas.
Institut Cochin de Génétique Moléculaire, U 129 Inserm, Paris.
N
N
Cartier
P
P
Briand
A
A
Kahn
D000818:Animals; D004032:Diet / Q000009:adverse effects*; D004195:Disease Models, Animal; D008114:Liver Neoplasms, Experimental / Q000209:etiology*; D051379:Mice; D008822:Mice, Transgenic; D010190:Pancreatic Neoplasms / Q000209:etiology*
Création de modèles de cancers dépendant du régime alimentaire par transgénèse chez l'animal.