Abnormal development of retinogeniculate X axons in strabismic cats: a possible substrate for visual dysfunction.
Rearing cats with surgically induced esotropia results in a number of structural and functional abnormalities in the visual system. In the present experiments, we have studied the morphology of individual retinogeniculate X axons in esotropic cats using intracellular recording and staining techniques. After serially reconstructing stained axonal arbors, we find that some X axon terminations in A-laminae of the lateral geniculate nucleus (LGN) have larger volumes and lower bouton densities than normal. This is true for X axons projecting from both the deviated and the non-deviated eye. It is possible that these abnormalities in morphological development contribute to the disruptions in signal transfer that has been observed in X-cells in the LGN of esotropic cats.
Garraghty
P E
PE
Department of Psychology, Indiana University, Bloomington 47405.
Roe
A W
AW
Chino
Y M
YM
Sur
M
M
D000818:Animals; D001369:Axons / Q000502:physiology*; D002415:Cats; D004948:Esotropia / Q000503:physiopathology*; D005829:Geniculate Bodies / Q000166:cytology / Q000254:growth & development / Q000503:physiopathology*; D012160:Retina / Q000166:cytology / Q000503:physiopathology*