[Progress in the red cell substitutes (artificial red cells)].
Recent progress of red cell substitutes to apply clinical use are overviewed. In response to the requisites as oxygen transporters, characteristics and present status are summarized for hemoglobin-based substitutes (polymer-conjugated Hb, polymerized Hb, crosslinked Hb). Concentrated hemoglobin covered with thin phospholipid bimolecular layer membranes (hemoglobin-vesicle) transports the sufficient amount of oxygen with excellent solution properties and safety. Furthermore, performances of two types of totally synthetic oxygen carrier are introduced such as lipid-heme embedding in the bilayer of a phospholipid vesicle and lipid-heme in the fat-microsphere composed of the emulsion for the nutrimental infusions.
Tsuchida
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Department Polymer Chemistry, Waseda University.
D000818:Animals; D001692:Biological Transport; D001802:Blood Substitutes; D006454:Hemoglobins; D006801:Humans; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D010100:Oxygen / Q000378:metabolism; D010316:Particle Size; D010743:Phospholipids; D011994:Recombinant Proteins
D001802:Blood Substitutes; D006454:Hemoglobins; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D010743:Phospholipids; D011994:Recombinant Proteins; D010100:Oxygen