Gene relaxation and aging: changes in the abundance of rat ventral prostate SGP-2 (clusterin) and ornithine decarboxylase mRNAs.
Sulfated glycoprotein 2 (SGP-2) mRNA progressively increased in the ventral prostate of the aging rat, reaching, at 24 months, 4-fold higher than at 3 months. Ornithine decarboxylase (ODC) mRNA peaked at 6 months (4-fold increase), and at 12 and 24 months was maintained at higher levels than at 3 months. ODC enzymatic activity was enhanced at 6 months to a much smaller extent than its own mRNA, the values at 12 and 24 months dropping to below those at 3 months. Putrescine (Put), spermidine (Spd) and spermine (Sp) concentrations also peaked at 6 months (100% increase for Put, 50% for Sp and Spd). At 24 months, Put and Spd were diminished, and Sp was unchanged with respect to the 3-month values. Under the same conditions, glyceraldehyde-3-phosphate dehydrogenase mRNA did not undergo significant alterations.
Dipartimento di Scienze Biomediche, University of Modena, Italy.
S
S
Bettuzzi
P
P
Strocchi
M
M
Marinelli
S
S
Astancolle
P
P
Davalli
A
A
Corti
D000375:Aging / Q000235:genetics*; D000818:Animals; D015152:Blotting, Northern; D051152:Clusterin; D015870:Gene Expression; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics*; D008297:Male; D018832:Molecular Chaperones; D009955:Ornithine Decarboxylase / Q000235:genetics*; D011073:Polyamines / Q000378:metabolism; D011467:Prostate / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones; D011073:Polyamines; D012333:RNA, Messenger; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D009955:Ornithine Decarboxylase