[The immune system indices of patients with pseudotuberculosis and concomitant chronic opisthorchiasis].
The quantitative characteristics of T and B-lymphocytes and their subpopulations (theophylline-resistant and theophylline-sensitive lymphocytes), the reaction of lymphocyte blast transformation (RLBT) after stimulation with phytohemagglutinin (PHA) and the level of circulating immune complexes (CIC) in pseudotuberculosis patients with and without concomitant opisthorchiasis were studied and compared. For control opisthorchiasis patients undergoing dehelminthization and healthy persons were examined. The following results were obtained: in most pseudotuberculosis patients Opisthorchis invasion contributed to the formation of stable and prolonged T lymphopenia, an increase in the content of theophylline-sensitive lymphocytes and CIC, hyporeactivity of T lymphocytes in RLBT. Immunodeficiency developing in chronic opisthorchiasis is reversible, i.e. successful dehelminthization leads to the normalization of immunological characteristics.
Chuĭkova
K I
KI
Vasil'ev
N V
NV
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000188:drug therapy / Q000276:immunology*; D011223:Praziquantel / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D015011:Yersinia pseudotuberculosis / Q000276:immunology*
D000936:Antigen-Antibody Complex; D011223:Praziquantel
Nekotorye pokazateli immunnoĭ sistemy u bol'nykh psevdotuberkulezom s soputstvuiushchim khronicheskim opistorkhozom.