Interaction between mianserin and acenocoumarin: a single case study.
A 62-year-old male patient, suffering from a hypertensive cardiopathy, an arteriopathy of the lower extremities and a type II insulin independent diabetes had a prothrombin time ratio R of 2.15 (therapeutic range: 2.1-1.45) during a daily treatment of 4-6 mg acenocoumarin. On admission to the psychiatric hospital for depression, a mianserin treatment was commenced, leading to a sharp modification in the PT ratio R, in effect that the acenocoumarin treatment had to be increased to keep R within the therapeutic range. The possible mechanism of this interaction between mianserin and acenocoumarin is discussed, taking into account the possible role of the comedicated amiodarone.
Baettig
D
D
Centre médico-psychologique, Service de psychiatrie pour adultes, Delémont, Switzerland.
Tillement
J P
JP
Baumann
P
P
D000074:Acenocoumarol / Q000627:therapeutic use*; D000638:Amiodarone / Q000494:pharmacology; D001778:Blood Coagulation Disorders / Q000150:complications / Q000188:drug therapy*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D011517:Prothrombin Time
D008803:Mianserin; D000074:Acenocoumarol; D000638:Amiodarone