Comparison of a transfusion preparation of newly formed red cells and standard washed red cell transfusions in patients with homozygous beta-thalassemia.
BACKGROUND
Previous studies of transfusions of newly formed red cells (neocytes) demonstrated modest extensions of transfusion interval in patients with homozygous beta-thalassemia.


METHODS
The clinical benefits of a new system of neocyte preparation (Neocel, Cutter Biological, Berkeley, CA), reported to combine ease of preparation with reduction in the transfusion requirements of thalassemia patients, were evaluated. Sixteen thalassemic patients who had undergone splenectomy received eight consecutive, standard, automated, washed red cell transfusions (standard transfusions), followed by eight transfusions with the neocyte preparation (neocyte transfusions). In each arm of the study, mean pretransfusion hemoglobin and mean red cell mass transfused were carefully controlled and were similar.


RESULTS
A significant (p < 0.0001) extension of transfusion interval was observed in patients receiving neocyte transfusions (mean +/- SD; 38.7 +/- 34 days; range, 35.0-44.5), over that in those receiving standard transfusions (32.9 +/- 2.5 days; range, 29.6-38.5). The mean prolongation of transfusion interval by neocyte transfusion corresponded to a mean reduction of 25 mL in packed red cells transfused per kg of body weight per patient per year and a mean reduction in transfused iron of 15 percent per year per patient. During neocyte transfusions, blood preparation costs were considerably increased and donor exposure was significantly (p < 0.0005) higher than during the standard transfusion period.


CONCLUSIONS
These data demonstrate that extension of the transfusion interval, and reduction in transfused iron, may be achieved in thalassemic patients by use of the Neocel system. These benefits are achieved, however, with substantial increases in donor exposure and in component preparation costs.
Collins
A F
AF
Canadian Red Cross, Toronto Center, Ontario, Canada.
Gonçalves-Dias
C
C
Haddad
S
S
Talbot
R
R
Herst
R
R
Tyler
B J
BJ
Zuber
E
E
Blanchette
V S
VS
Olivieri
N F
NF
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002648:Child; D004905:Erythrocyte Aging; D017707:Erythrocyte Transfusion / Q000191:economics / Q000379:methods*; D005260:Female; D005293:Ferritins / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D013156:Splenectomy; D017086:beta-Thalassemia / Q000628:therapy*
D005293:Ferritins; D007501:Iron