Long-term dietary vitamin E retards development of retrovirus-induced disregulation in cytokine production.
A 15-fold increase in dietary vitamin E (160 IU/liter) normalized hepatic and serum levels of vitamin E normally reduced by retrovirus infection. It also significantly retarded development of splenomegaly and hypergammaglobulinemia induced by retrovirus infection, while significantly restoring release of interleukin-2 (IL) and interferon-gamma by splenocytes which are suppressed by retrovirus infection. Retrovirus infection elevated production of IL-4 and IL-6 by splenocytes, but this elevation was inhibited by vitamin E. Increased levels of IL-6 and tumor necrosis factor-alpha produced by splenocytes during progression to murine AIDS were also inhibited by vitamin E. Vitamin E supplementation also helped restore retrovirus-suppressed splenocyte proliferation. These data indicate that vitamin E supplementation can help overcome retrovirus-induced reduction in tissue vitamin E, modulate cytokine release, and normalize immune dysfunctions during progression to murine AIDS.
Department of Family and Community Medicine, University of Arizona, Tucson 85724.
Y
Y
Wang
D S
DS
Huang
C D
CD
Eskelson
R R
RR
Watson
D000818:Animals; D000911:Antibodies, Monoclonal; D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology*; D004032:Diet; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006942:Hypergammaglobulinemia / Q000382:microbiology / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy*; D013154:Spleen / Q000166:cytology; D013163:Splenomegaly / Q000382:microbiology / Q000628:therapy; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014810:Vitamin E / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D016207:Cytokines; D014810:Vitamin E