A novel genetic thrombocytopenia (Paris-Trousseau) associated with platelet inclusions, dysmegakaryopoiesis and chromosome deletion AT 11q23.
We report a novel case of hereditary thrombocytopenia. A chronic thrombocytopenia was noted in a woman with mild hemorrhagic complications as well as in her very young son. A platelet fraction contained giant granules stained in red on blood smears. The number of bone marrow megakaryocytes was increased with many micromegakaryocytes. Since the platelet life span was normal, these results indicated an ineffective platelet production. A constitutional cytogenetic abnormality was detected in the two patients: a deletion of the long arm of chromosome 11. The association of these abnormalities constitute a new disorder: this never described cytological entity is a valuable model for exploring the role of some genes involved in the regulation of thrombopoiesis.
Laboratoire Central d'Hématologie, Hôpital d'enfants Armand-Trousseau, Paris, France.
R
R
Favier
L
L
Douay
B
B
Esteva
M F
MF
Portnoi
P
P
Gaulard
T
T
Lecompte
C
C
Perot
M
M
Adam
C
C
Lecrubier
J
J
Van den Akker
D000328:Adult; D001792:Blood Platelets / Q000648:ultrastructure*; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D007223:Infant; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D013921:Thrombocytopenia / Q000150:complications* / Q000235:genetics / Q000473:pathology