Derivatives of 2-mercaptyobenzenesulphonamide. XIII. Syntheses and somepharmacological properties of 1-4-chloro-2-(dialkylaminoalkylthio)-5- methylbenzenesulphonyl)-2-imidazolidinone hydrochlorides.
Syntheses of 1-[4-chloro-2-(dialkylaminoalkylthio)-5- methylbenzenesulphonyl]-2-imidazolidones [II-X] and their hydrochlorides [IIa-Xa] are described. The results of preliminary pharmacological examination such as acute toxicity and influence on circulatory system are presented.
Brzozowski
Z
Z
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
Pomarnacka
E
E
Kosmala
M
M
Filczewski
M
M
Oledzka
K
K
Lewandowski
K
K
Miłobedzka
J
J
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D007093:Imidazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D051381:Rats; D013449:Sulfonamides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D013449:Sulfonamides