KEKE motifs. Proposed roles in protein-protein association and presentation of peptides by MHC class I receptors.
A stretch of 28 'alternating' lysine (K) and glutamate (E) residues is found in an activator of the multicatalytic protease. Such 'KEKE sequences' are also present in subunits of the multicatalytic protease, in subunits of the 26S protease and in a variety of chaperonins. We propose that KEKE regions promote association between protein complexes. Furthermore, they may contribute to the selection of peptides presented on MHC Class I receptors.
Realini
C
C
Department of Biochemistry, University of Utah, Salt Lake City 84132.
Rogers
S W
SW
Rechsteiner
M
M
D000595:Amino Acid Sequence; D017951:Antigen Presentation; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism; D004789:Enzyme Activation; D005973:Glutamine / Q000737:chemistry; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000276:immunology; D008239:Lysine / Q000737:chemistry; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism; D010446:Peptide Fragments / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000737:chemistry*; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D009097:Multienzyme Complexes; D010446:Peptide Fragments; D011506:Proteins; D011971:Receptors, Immunologic; D005973:Glutamine; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D008239:Lysine