MIF proteins are not glutathione transferase homologs.
Although macrophage migration inhibitory factor (MIF) proteins conjugate glutathione, sequence analysis does not support their homology to other glutathione transferases. Glutathione transferases are not detected with MIF proteins in searches of protein sequence databases, and MIF proteins do not share significant sequence similarity with glutathione transferases. Homology cannot be demonstrated by multiple sequence alignment or evolutionary tree construction; such methods assume that the proteins being analyzed are homologous.
Pearson
W R
WR
Department of Biochemistry, University of Virginia, Charlottesville 22908.
D000818:Animals; D005075:Biological Evolution; D016208:Databases, Factual; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D019746:Intramolecular Oxidoreductases; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D051379:Mice; D011506:Proteins / Q000235:genetics; D051381:Rats; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D008263:Macrophage Migration-Inhibitory Factors; D011506:Proteins; D005982:Glutathione Transferase; D019746:Intramolecular Oxidoreductases; C076231:Mif protein, mouse