Renal oncocytoma with a translocation t(9;11)(p23;q13).
We report a case of renal oncocytoma and confirm a tumor type specific translocation between chromosomes 9 and 11, that is t(9;11)(p23;q13q23). Each of the 45 cytogenetically analyzed metaphases of tumor cells showed a translocation of the long arm of chromosome 11 at q13 to chromosome 9 at 9p23 and to chromosome 20 at 20q13 that resulted in the following karyotype: 46,XX,der(11)ins(9;11)(p23;q13q23)ins(20;11)(q13;q23q25),del (22q13). Since genes encoding mitochondrial enzymes are clustered around the translocation site of chromosomes 11 and 20, they may have a role in the tumorigenesis of renal oncocytoma. In addition, if the development of oncocytomas shows different cytogenetic pathways the cytogenetic aberration of t(9;11)(p23;q12q13) can be of diagnostic help in differentiating a subset of oncocytoma from renal cell carcinoma.
Institute of Pathology, Medical School of the Technical University, Aachen, Germany.
L
L
Füzesi
B
B
Gunawan
S
S
Braun
W
W
Boeckmann
D018249:Adenoma, Oxyphilic / Q000235:genetics*; D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic