Impaired spatial learning by vasoactive intestinal peptide in Morris water maze task in the rat.
Intracerebroventricular administration of vasoactive intestinal peptide (VIP) disturbed the learning by rats of the location of a platform submerged in a water pool. When the platform was removed from the pool, VIP injection produced marked impairment of the ability to find a previously learned location in the pool. This spatial memory impairment caused by VIP was restored by peripheral pre-administration of cerulein.
Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
S
S
Itoh
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A
Takashima
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Morimoto
D000818:Animals; D002108:Ceruletide / Q000494:pharmacology; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D010446:Peptide Fragments; C056384:vasoactive intestinal peptide (1-12); D014660:Vasoactive Intestinal Peptide; D002108:Ceruletide