Initiation codons within 5'-leaders of mRNAs as regulators of translation.
Why should a preponderance of proto-oncogenes, growth factor genes and growth factor receptor genes contain translation initiation codons and associated open reading frames in their 5'-leaders? An increasing number of open reading frames are being shown to function as cis-acting regulatory signals able to moderate expression of the downstream reading frame. These regulatory elements could play a fundamental role in the regulation of proliferation of vertebrate cells.
Geballe
A P
AP
Department of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Morris
D R
DR
D003062:Codon; D004268:DNA-Binding Proteins; D005656:Fungal Proteins / Q000235:genetics; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000235:genetics; D012333:RNA, Messenger / Q000737:chemistry*; D012045:Regulatory Sequences, Nucleic Acid; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors
D003062:Codon; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D011494:Protein Kinases