Cretinism after weekly dosing with levothyroxine for treatment of congenital hypothyroidism.
An 11-month-old infant was treated elsewhere for congenital hypothyroidism with weekly doses of levothyroxine. The infant had cardinal features of cretinism including poor growth, delayed skeletal maturation, and mental retardation. Treatment of such infants with weekly doses of levothyroxine cannot be justified.
Pediatric Endocrine Unit, James Whitcomb Riley Hospital, Indiana University School of Medicine, Indianapolis 46202.
S A
SA
Rivkees
D S
DS
Hardin
D001989:Bronchiolitis Obliterans / Q000209:etiology; D003409:Congenital Hypothyroidism / Q000209:etiology*; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy*; D007223:Infant; D013974:Thyroxine / Q000008:administration & dosage*
D013974:Thyroxine