Antitumor activity of bacteria and bacterial products: enhancement of the tumor-protective effect of bacteria by lipoteichoic acid.
The ability of some microbial agents and/or their products to affect local tumor growth was assessed in the D-12 DA rat ascites tumor model. Various bacteria and bacterial products markedly enhanced tumor resistance when injected i.p. several days before tumor cell challenge. The tumor-protective effect of these compounds was amplified further by lipoteichoic acid (LTA) inoculated i.p. a few days after tumor cell challenge. Under these conditions, the majority of animals did not exhibit progressive tumor growth.
Department of Pathology, University Hospital, University of Zurich, Switzerland.
R
R
Keller
R
R
Keist
J E
JE
Gustafson
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D007167:Immunotherapy; D008070:Lipopolysaccharides / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000628:therapy*; D010457:Peptidoglycan / Q000627:therapeutic use*; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013682:Teichoic Acids / Q000494:pharmacology*
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D011135:Polysaccharides, Bacterial; D013682:Teichoic Acids; C009900:lipoteichoic acid; D015127:9,10-Dimethyl-1,2-benzanthracene