The B cell antigen receptor in B-cell development.
During B-cell development, immature and mature forms of the B cell antigen receptor complex are deployed in a regulated fashion; thus, B cell antigen receptor complexes play essential roles in the transit of cells through ontogeny. The past year has seen progress in our understanding of how antigen receptor gene assembly is controlled and in defining the requirements for antigen receptor mediated signaling at specific developmental stages. The discovery that a defective protein tyrosine kinase is responsible for X-linked agammaglobulinemia in man and X-linked immunodeficiency in the mouse is particularly interesting, as it may provide the means to link a specific intracellular signaling pathway with a particular step in B-cell development.
Desiderio
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Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185.
D000595:Amino Acid Sequence; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000201:enzymology / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D005314:Embryonic and Fetal Development; D005434:Flow Cytometry; D006801:Humans; D007107:Immune System / Q000254:growth & development*; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000502:physiology*; D011995:Recombination, Genetic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases