[The importance of studies of calcium reabsorption and of the capacity of the blood plasma to inhibit Ca-ATPase activity for the diagnosis of the activity of the inflammatory process and for the prognosis of tubular function in patients with chronic pyelonephritis].
The contribution of pyelonephritis activity to calcium reabsorption defects was investigated in 176 patients with chronic pyelonephritis (CP) aged 18-54 with normal tubular filtration and calcium serum concentrations under calcium reabsorption above 98%. 86 of these patients had CP complicated by nonocclusive pelvic stones. Ca-excretory capacity of the kidneys was evaluated with estimation of the excreted calcium by activity phases considering individual deviations or without them. Measurements were also made of CP activity and severity by the inhibition of Ca-ATPase activity of the microsomes isolated from rat intact kidneys. The findings indicate that in active CP calcium-reabsorption impairments related to the inflammation are combined with the preexisting ones, the changes being more pronounced with growing activity of the inflammation, irrespective of the presence of nephrolithiasis. The relationship established between the shifts in excreted calcium induced by inflammation and plasma ability of CP patients to inhibit Ca-ATPase activity of rat renal microsomes in single tests in the same patients allows assessment of calcium reabsorption changes due to CP activity in patients when analysing their blood inhibitory effect on the test enzyme system. Simultaneous one-stage determination in CP patients of their blood inhibition in response to the test enzyme system and excreted calcium helps prognosticate calcium reabsorption expected in remission.
Golod
E A
EA
Onishchenko
N A
NA
D000042:Absorption; D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007669:Kidney Calculi / Q000175:diagnosis / Q000503:physiopathology; D007684:Kidney Tubules / Q000503:physiopathology*; D008875:Middle Aged; D011379:Prognosis; D011704:Pyelonephritis / Q000175:diagnosis* / Q000503:physiopathology
D000252:Calcium-Transporting ATPases; D002118:Calcium
Znachenie issledovaniĭ reabsorbtsii kal'tsiia i sposobnosti plazmy krovi ingibirovat' Ca-ATFaznuiu aktivnost' dlia diagnostiki aktivnosti vospalitel'nogo protsessa i prognozivovaniia sostoianiia kanal'tsev u bol'nykh khronicheskim pielonefritom.