Simultaneous urography and determination of glomerular filtration rate. A comparison of total plasma clearances of iohexol and 51Cr-EDTA in plegic patients.
The total plasma clearance of iohexol at urography and 51Cr-EDTA was compared in 31 patients with di- or tetraparesis. A reference 51Cr-EDTA clearance was also performed 24 hours prior to the urography. The GFR was calculated from one, 2 or 4 plasma samples collected 180, 210, 240 and 270 min after the injection. An X-ray fluorescence analyzer was used for the analysis of iohexol in plasma as well as the contrast medium clearance calculations. It was shown that single or multiple sample clearance of iohexol and 51Cr-EDTA were equivalent methods for measurement of the GFR. The GFR was not affected by iohexol in a dose routinely used for urography. It was concluded that the patient comfort is improved if 51Cr-EDTA clearance is replaced by contrast medium clearance in association with urography.
Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.
S
S
Lundqvist
S O
SO
Hietala
C
C
Berglund
K
K
Karp
D000328:Adult; D000368:Aged; D001830:Body Surface Area; D002860:Chromium Radioisotopes / Q000097:blood*; D004492:Edetic Acid / Q000493:pharmacokinetics* / Q000494:pharmacology; D005260:Female; D005453:Fluorescence; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007472:Iohexol / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010264:Paraplegia / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011782:Quadriplegia / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013997:Time Factors; D014567:Urography
D002860:Chromium Radioisotopes; D007472:Iohexol; D004492:Edetic Acid