Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis.
Hepatic polyamines were assayed in 15 patients with liver diseases, 5 with fulminant hepatitis (FH); 3 with exacerbated liver cirrhosis (ELC); and 7 with liver cirrhosis (LC). Hepatic putrescine and N1-acetylspermidine as percentages of total polyamines, were elevated and spermine was decreased in all 15 patients. The increase in hepatic N1-acetylspermidine levels appeared to be greater in patients with FH and ELC than in those with LC. These results suggest that the production of N1-acetylspermidine in human liver is closely associated with the induction of spermidine/spermine N1-acetyltransferase activity in liver diseases.
Department of Physiology, School of Medicine, Gunma University, Maebashi, Japan.
H
H
Sugimoto
S
S
Sakurai
T
T
Abe
H
H
Takagi
H
H
Takahashi
J
J
Takezawa
T
T
Nagamine
S
S
Matsuzaki
D000123:Acetyltransferases / Q000378:metabolism; D000328:Adult; D000368:Aged; D005260:Female; D006501:Hepatic Encephalopathy / Q000378:metabolism*; D006505:Hepatitis / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011700:Putrescine / Q000378:metabolism*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000378:metabolism; D000099228:Diamine N-Acetyltransferase
D000123:Acetyltransferases; D011700:Putrescine; D013095:Spermidine; D000099228:Diamine N-Acetyltransferase; C017988:N(1)-acetylspermidine