[Molecular analysis of the development of the rhombencephalon].
Hindbrain development involves a segmentation process which in particular governs cranial-motor nerves organization. We have initiated a molecular analysis of this morphogenetic process by searching for genes expressed in specific hindbrain segments (rhombomeres). We have identified a gene encoding a transcription factor, Krox-20, which is specific of rhombomeres 3 and 5 and several genes encoding receptor tyrosine kinases which are also segment-specific. The study of Krox-20 has allowed the identification of its nucleotide target, the localization of the functional domains of the protein and the demonstration of its involvement in the transcriptional activation of the Hoxb-2 gene and in the control of normal hindbrain development.
INSERM U 368, Biologie Moléculaire du Développement, Ecole Normale Supérieure, Paris.
C
C
Vesque
P
P
Topilko
N
N
Becker
P
P
Charnay
D000818:Animals; D066298:In Vitro Techniques; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D012249:Rhombencephalon / Q000196:embryology* / Q000378:metabolism*; D015533:Transcriptional Activation; D016335:Zinc Fingers / Q000235:genetics
D020794:Receptor Protein-Tyrosine Kinases
Analyse moléculaire du développement du rhombencéphale.