Reducing conservatism in risk estimation for mixtures of carcinogens.
The excess cancer risk that might result from exposure to a mixture of chemical carcinogens usually must be estimated using data from experiments conducted with individual chemicals. In estimating such risk, it is commonly assumed that the total risk due to the mixture is the sum of the risks of the individual components, provided that the risks associated with individual chemicals at levels present in the mixture are low. This assumption, while itself not necessarily conservative, has led to the conservative practice of summing individual upper-bound risk estimates in order to obtain an upper bound on the total excess cancer risk for a mixture. Less conservative procedures are described here and are illustrated for the case of a mixture of four carcinogens.
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
R L
RL
Kodell
J J
JJ
Chen
D000818:Animals; D002273:Carcinogens / Q000737:chemistry*; D016001:Confidence Intervals; D004781:Environmental Exposure; D005260:Female; D016013:Likelihood Functions; D016014:Linear Models; D008297:Male; D051379:Mice; D015233:Models, Statistical; D051381:Rats; D012307:Risk Factors
D002273:Carcinogens