Genetic variation in experimental dental caries in four inbred strains of rats.
The relative contribution of the host genetic effect on the susceptibility to dental caries was examined. Four inbred strains of male rats (BN/Sea, F344/Ms, PVG/cSea, and WKA/Sea) were inoculated with Streptococcus mutans and fed a cariogenic diet. The caries scores of the molar teeth were compared among these four strains, and the degree of genetic determination was estimated by analysis of variance. Statistically significant differences in caries scores were found among these strains (F344 > WKA > PVG/c > BN), and a high degree of genetic determination was obtained.
Kanamoto
T
T
Department of Pediatric Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan.
Nonaka
K
K
Nakata
M
M
D000704:Analysis of Variance; D000818:Animals; D015169:Colony Count, Microbial; D003733:Dental Caries Susceptibility / Q000235:genetics*; D004037:Diet, Cariogenic; D014644:Genetic Variation; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013295:Streptococcus mutans / Q000472:pathogenicity