[Studies on semi-synthesis of cephalotaxine esters and correlation of their structures with antitumor activity].
Ten esters of cephalotaxine with amino acids possessing widely different structural features have been synthesized and tested for antitumor activity. Preliminary data showed that compound 6 is the most active one. However, it is still less potent than harringtonine. Other synthetic esters possess varying activities at 10 micrograms/ml. Preliminary structure activity relationship of these esters was discussed.
Zhong
S B
SB
School of Pharmaceutical Sciences, Beijing Medical University.
Liu
W C
WC
Li
R L
RL
Ling
Y Z
YZ
Li
C H
CH
Tu
G Z
GZ
Ma
L B
LB
Hong
S L
SL
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006248:Harringtonines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000077863:Homoharringtonine; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D006248:Harringtonines; D000077863:Homoharringtonine