[Malignant pleomorphic adenoma of the salivary gland: a clinicopathological and immunohistochemical study].
Eighty three cases of malignant pleomorphic adenomas (MPA) of salivary glands were studied. Twenty tumors among of them were labeled with 4 kinds of antibodies including anti-CEA, anti-S 100 P, anti-CK12 and CK27 by immunohistochemical staining. Based on this study, it was concluded that the majority cases of MPAs derived from malignant transformation of benign pleomorphous adenomas. The author suggested that the MPAs might be classified as carcinomatous and carcino-sarcomatous subtypes according to the histologic appearances of malignant component in the tumor. The CEA positive reaction in the cytoplasm of tumor cells was a reliable marker of malignancy.
Ji
X L
XL
School of Stomatology, Shanghai Second Medical University.
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen