Neuropeptides and alcohol addiction in monkeys.
Neuropeptides have been implicated in experimental drug addiction. Desglycinamide (Arg8) vasopressin (DGAVP) attenuates heroin and cocaine intake during initiation of drug self-administration in rats. beta-Endorphin is self-administered in rats and a role of endogenous opioids in cocaine reward has been proposed. The present studies deal with voluntary alcohol consumption in monkeys under free choice conditions. Monkeys initiated alcohol drinking within a few days and after a stable drinking pattern was acquired increased their ethanol consumption during a short period following interruption of the alcohol supply (relapse). The alcohol drinking behavior seems under the control of reinforcement principles. DGAVP reduced the acquisition of alcohol drinking in the majority of treated monkeys. Initiation of alcohol drinking induced modifications in neuroendocrine homeostasis e.g. an increased plasma beta-endorphin. Both the opioid antagonist naltrexone and the opioid agonist morphine dose-dependently decreased alcohol intake during continuous supply and after imposed abstinence. The monkeys were more sensitive to both drugs after imposed abstinence. The effects are interpreted in the context of the endorphin compensation hypothesis of addictive behavior. It is suggested that endorphins may be particularly implicated in craving for addictive drugs and in relapse of addictive behavior.
Department of Pharmacology, Rudolf Magnus Institute, Utrecht University, The Netherlands.
J M
JM
van Ree
M
M
Kornet
C
C
Goosen
D000437:Alcoholism / Q000503:physiopathology* / Q000517:prevention & control / Q000523:psychology; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009479:Neuropeptides / Q000502:physiology*; D051381:Rats; D012054:Reinforcement, Psychology; D012646:Self Administration; D001615:beta-Endorphin / Q000097:blood / Q000502:physiology
D009479:Neuropeptides; D000431:Ethanol; D009271:Naltrexone; D001615:beta-Endorphin; D009020:Morphine