[Intraductal spread of carcinoma: a risk for breast conserving surgery].
Intraductal spread of carcinoma (ISC) was defined as "DCIS clearly present extending beyond terminal duct-lobular unit, or present prominently within large ducts," using a sequential slicing of tissues and 3-D reconstruction of tumors. We then analyzed the relationship between ISC in specimens obtained by breast conserving surgery (BCS) and carcinoma residue in specimens obtained by total mastectomy. We found a strong correlation between the ISC factor in BCS tissues and the carcinoma residue in mastectomy specimens. Among 12 patients under observation without mastectomy, 3 patients subsequently developed breast carcinoma. Two of the 3 patients demonstrated ISC in BCS specimens. One of 10 patients without ISC, however, developed carcinoma, suggesting that the ISC is a risk factor in breast conserving surgery for breast cancer patients.
Second Dept. of Surgery, Tohoku University School of Medicine.
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N
Ohuchi
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A
Furuta
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Mori
D000328:Adult; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D015413:Mastectomy, Simple; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012306:Risk