[Immunohistochemical distribution and fine localization of atrial natriuretic peptides in the stria vascularis of normal guinea pigs].
The paper presents the distribution and fine localization of the atrial natriuretic peptides (ANP) in the stria vascularis of normal guinea pig by using immunohistochemical technique (ABC method) and immunoelectronic microscopy. ANP-IR was found in stria vascularis in all turns of the lateral walls of cochlea, but no positive products were found in the spiral ligament. The positive immunoreactive products were seen more distinct in the liber surface than that of basilaris. A large of spherical bodies whose diameters are 250-350nm were seen in cytoplasm of marginal cells and intermediate cells in stria vascularis; spheroid is less in the cytoplasm of basal cells and vascular endothelial cells. The study suggests that the stria vascularis can secrete ANP. ANP morphological distribution and its possible meaning in the stria vascularis are discussed.
Xijing Hospital, 4th Military Medical University, Xi'an.
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H
Chen
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D013316:Stria Vascularis / Q000737:chemistry* / Q000648:ultrastructure
D009320:Atrial Natriuretic Factor