[The relationship of the intensity of antibody formation to the causative agents of diphtheria and tetanus to genetic markers in children vaccinated with adsorbed DPT].
The examination of 99 children immunized with adsorbed DPT vaccine revealed that the intensity of immune response to the diphtheria and tetanus components of the preparation were linked with a number of genetic markers (respectively, HLA-A9, B35, etc.; HLA-A25, B8, etc.) and their combinations. The groups of children with high and low sensitivity include an elevated number of persons with the corresponding titers of antibodies of other specificity. The results obtained in this study should be considered in working out individual immunization schedules.
Prilutskiĭ
A S
AS
Sokhin
A A
AA
Maĭlian
E A
EA
Koteneva
G E
GE
Lugovaia
Iu V
IuV
D000327:Adsorption; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D000918:Antibody Specificity / Q000235:genetics / Q000276:immunology; D001789:Blood Group Antigens / Q000235:genetics / Q000276:immunology; D003017:Clostridium tetani / Q000276:immunology*; D003353:Corynebacterium diphtheriae / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant
D000907:Antibodies, Bacterial; D001789:Blood Group Antigens; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens
Sviaz' intensivnosti vyrabotki antitel k vozbuditeliam difterii i stolbniaka s nekotorymi geneticheskimi markerami u deteĭ, vaktsinirovannykh AKDS.