In situ hybridization study of mu- and kappa-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia.
Distributions of mu- and kappa-opioid receptor mRNAs in the lumbar spinal cord and dorsal root ganglia of the adult rat were examined using the in situ hybridization technique. In the lumbar spinal cord, mu-opioid receptor mRNA was expressed intensely in laminae I, II and VIII. On the other hand, kappa-opioid receptor mRNA was expressed intensely in laminae I and II, and moderately throughout laminae III-VIII. In the dorsal root ganglia, mu-opioid receptor mRNA was intensely expressed and kappa-opioid receptor mRNA was expressed in a smaller number of cells than mu-opioid receptor mRNA.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
K
K
Maekawa
M
M
Minami
K
K
Yabuuchi
T
T
Toya
Y
Y
Katao
Y
Y
Hosoi
T
T
Onogi
M
M
Satoh
D000818:Animals; D016375:Antisense Elements (Genetics); D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism*; D015870:Gene Expression; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000096:biosynthesis*; D017450:Receptors, Opioid, mu / Q000096:biosynthesis*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
D016375:Antisense Elements (Genetics); D012333:RNA, Messenger; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu