Association of polyomavirus middle tumor antigen with 14-3-3 proteins.
To carry out its transformation function, the middle tumor antigen (MT) of murine polyomavirus associates with a number of cellular proteins involved in regulation of cell proliferation, including pp60c-Src, phosphatidylinositol 3-kinase, protein phosphatase 2A, Src homologous and collagen protein and growth factor receptor-binding protein 2. Here, two additional MT-associated proteins were identified as members of the 14-3-3 family of proteins. Yeast homologs of 14-3-3 proteins have recently been shown to play a role in the timing of mitosis. Thus, regulation of 14-3-3 protein function by MT may contribute to the development of neoplasia.
Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA.
D C
DC
Pallas
H
H
Fu
L C
LC
Haehnel
W
W
Weller
R J
RJ
Collier
T M
TM
Roberts
D048948:14-3-3 Proteins; D016475:3T3 Cells; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000276:immunology / Q000378:metabolism*; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006801:Humans; D007106:Immune Sera; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011233:Precipitin Tests; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D000952:Antigens, Polyomavirus Transforming; D007106:Immune Sera; D009419:Nerve Tissue Proteins; D000246:Adenosine Diphosphate Ribose; D014446:Tyrosine 3-Monooxygenase; D011065:Poly(ADP-ribose) Polymerases