[Certain etiopathogenic factors of irritable colon syndrome].
In a group of 74 patients with irritable colon syndrome (ICS) the studies were carried out evaluating the participation of early allergic reaction to meals, depression, and indices of immune response in the aetiology and pathogenesis of this syndrome. An attempt was also undertaken at evaluation of the influence of depression on the immune system functions in these patients. Clinical reactions after meals were reported by 89% of the studied patients with ICS, and in 8% of these patients it was recognized that early allergic reaction to meals had been the pathological mechanism responsible for the observed reactions. The intensity of depression and the per cent of patients with depression were statistically higher in patients with ICS as compared with persons in the control group. The number of Ea rosette forming T-cells was decreased in patients with ICS significantly in comparison to controls. The numbers of T- and B-cells were decreased statistically significantly in patients with depression intensity of 50 and over 50 points as compared with those without depression. In certain patients other immunological abnormalities were also found, such as decreased serum IgA level combined with absence of that Ig in the large bowel mucosa. The studies carried out suggest the statement that abnormal reactions after meal are common in patients with ICS and the participation of type I allergy according to Gell and Coombs in these reactions has been shown in 8% of the studied patients, and that the participation of psychopathological changes should be considered in the aetiology and pathogenesis of this syndrome.(ABSTRACT TRUNCATED AT 250 WORDS)
Katedry i Kliniki Gastroenterologii i Chorób Wewnetrznych Ak. Med., Bydgoszczy.
M
M
Swiatkowski
D000293:Adolescent; D000328:Adult; D000368:Aged; D003109:Colonic Diseases, Functional / Q000209:etiology*; D003863:Depression / Q000150:complications / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged
Niektóre czynniki etiopatogenetyczne zespołu jelita nadwrazliwego.