Extra-weak chemiluminescence of drugs. XV. Method for determining stability of Toki-shakuyaku-san extract granules.
The purpose of the study was to evaluate the quality of Toki-shakuyaku-san extract granules (TJ-23) using chemiluminescence (CL). A linear relationship was obtained between the log value of the CL of TJ-23 and the reaction temperature. An excellent correlation (r = 0.999) was found between the slope of this curve (delta A) and the colour intensity due to the browning reaction occurring at the early stage of the Maillard reaction.
Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.
H
H
Sato
H
H
Hirayama
T
T
Yamamoto
Y
Y
Ichio
F
F
Ishizawa
M
M
Mizugaki
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal; D008163:Luminescent Measurements; D010946:Plants, Medicinal / Q000737:chemistry*; D011874:Radiometry / Q000379:methods; D013816:Thermodynamics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C413220:toki-shakuyaku-san