Topical anesthetic induced pain as a diagnostic tool for kerato conjunctivitis sicca (KCS).
Duration and intensity of pain induced by instillation of an acid local anesthetic eyedrop were compared in 321 normals and 77 KCS-patients. The medium duration of pain was increased in KCS-patients (16.23 s) compared to normals (7.64 s). Also the main intensity of pain was increased (KCS: 1.34, normals 0.63). Both differences were highly significant (< 0.001). The sensitivity of duration (limit 12 s) was 64% and the specificity 69%. Except BUT this very simple test is the only one that uses a well defined stress to the tear film to test its capacity for adaptation. Furthermore it is the first KCS-test, that includes the individual sensitivity, which is an important parameter for assessment of KCS-patients.
Stolze
H H
HH
Augenklinik der RWTH, Aachen, Germany.
Volprecht
A
A
Welter
U
U
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local; D005260:Female; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010147:Pain Measurement; D011343:Procaine / Q000031:analogs & derivatives; D012680:Sensitivity and Specificity
D000779:Anesthetics, Local; D011343:Procaine; C005298:benoxinate