Physiological and environmental aspects of drinking stimulated by chronic exposure to amphetamine in rats.
1. To examine whether the hyperdipsic response to chronic administration of d,l-amphetamine (AMPH) is associated with modification of salt appetite, rats were allowed to choose between tap water and a 1.7% NaCl solution. 2. Under AMPH rats preferred water to saline throughout the experiment. 3. By testing rats in a distinct test cage environmental influences on AMPH-mediated hyperdipsia were also evaluated. 4. In the test cage hyperdipsia was suppressed, but preference for tap water was preserved. 5. Finally, the role of alpha 2-adrenoceptors in the drinking response to AMPH was evaluated by studying the effects of clonidine and yohimbine on water intake. 6. We conclude that AMPH-induced preference for tap water over saline is unrelated to hyperdipsia but, being also induced by yohimbine, it may depend on noradrenergic mechanisms.
Camanni
S
S
Institute of Medical Pharmacology, University La Sapienza, Rome, Italy.
Nencini
P
P
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm; D003000:Clonidine / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D004777:Environment; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; D012965:Sodium Chloride; D000661:Amphetamine; D003000:Clonidine