Anti-ulcer effect of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid on experimental gastric ulcers in rats.
The effects of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid (MAR-99, CAS 98772-05-5) on various experimental gastric ulcers were studied in rats. MAR-99 (3-100 mg/kg, p.o. or i.d.) showed the anti-ulcer effect in Shay-, stress, acetylsalicylic acid (ASA)- and compound 48/80-ulcer models and significantly accelerated healing of acetic acid-induced gastric ulcer in rats. In addition, MAR-99 (1-10 mg/kg p.o.) decreased dose-dependently the gastric mucosal damage induced by necrotizing agents such as 99.5% ethanol, 0.6N HCl and 0.2 N NaOH. These results indicate that MAR-99 may be useful for the treatment of gastric ulcer in human.
Ishizuka
Y
Y
Research Laboratories, Roussel Morishita Co., Ltd., Shiga, Japan.
Kamisaki
T
T
Matsuda
M
M
Shimazaki
I
I
Kawashima
M
M
Yaginuma
H
H
Terashima
K
K
Sato
M
M
D000085:Acetates; D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001241:Aspirin; D002927:Cimetidine / Q000494:pharmacology; D000431:Ethanol; D006851:Hydrochloric Acid; D008297:Male; D011708:Pylorus / Q000502:physiology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012972:Sodium Hydroxide; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D014148:Tranexamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine
D000085:Acetates; D000897:Anti-Ulcer Agents; D011743:Pyrimidines; D000431:Ethanol; D003189:p-Methoxy-N-methylphenethylamine; D012972:Sodium Hydroxide; C000665:cetraxate; D014148:Tranexamic Acid; D002927:Cimetidine; C087838:MAR 99; D006851:Hydrochloric Acid; D001241:Aspirin