Surveillance and prophylactic intervention of Staphylococcus aureus nasal colonization in a hemodialysis unit.
Surveillance of 101 hemodialysis patients for Staphylococcus aureus positive nasal cultures was performed by monthly nasal swabs over a 27-month period. All positive cultures were treated with a prophylactic antibiotic regimen. Forty-seven (46.5%) patients had one or more positive cultures. The surveillance period was longer in the S. aureus nasal carriers (p = 0.004). The frequency of positive cultures correlated with the duration of surveillance (p = 0.029). The incidence of S. aureus bacteremia was greater in patients with two or more positive cultures (p = 0.030). This study suggests that continuous surveillance for S. aureus nasal colonization is essential to properly identify all patients at risk of developing S. aureus bacteremias.
Glowacki
L S
LS
Division of Nephrology, St. Joseph's Health Centre, London, Ont., Canada.
Hodsman
A B
AB
Hammerberg
O
O
Meraw
J
J
McNeill
V
V
Card
M L
ML
Potters
H
H
McGhie
K
K
Stitt
L W
LW
D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000453:epidemiology / Q000517:prevention & control*; D015331:Cohort Studies; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D006436:Hemodialysis Units, Hospital; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000382:microbiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000382:microbiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013997:Time Factors
D000900:Anti-Bacterial Agents