Surgical therapy for gestational trophoblastic disease.
Current successful therapy for women with gestational trophoblastic disease (GTD) is based upon the use of sensitive assays for human chorionic gonadotropin to monitor disease status and individualized application of chemotherapy based upon recognized risk factors. However, surgical therapy continues to play a role in the management of GTD. Suction dilation and curettage and hysterectomy are used for primary therapy for hydatidiform mole. Hysterectomy may be used as an adjunct to the primary management of selected patients with malignant GTD. Other extirpative procedures, such as thoracotomy, may be integrated into the management of drug-resistant disease.
Soper
J T
JT
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002405:Catheterization, Central Venous; D006063:Chorionic Gonadotropin / Q000097:blood; D003131:Combined Modality Therapy; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007751:Labor, Induced / Q000379:methods; D011247:Pregnancy; D011379:Prognosis; D012307:Risk Factors; D014328:Trophoblastic Neoplasms / Q000097:blood / Q000453:epidemiology / Q000601:surgery*; D014594:Uterine Neoplasms / Q000097:blood / Q000453:epidemiology / Q000601:surgery*; D014620:Vacuum Extraction, Obstetrical / Q000379:methods
D000970:Antineoplastic Agents; D006063:Chorionic Gonadotropin