Suppression of murine melanoma growth with a combination of microwave hyperthermia and local injection of interleukin 2.
Local microwave hyperthermia in combination with local injections of interleukin 2 (IL-2) was found to exert a remarkable suppressive effect on murine melanoma growth. Both of these therapeutic modalities caused marked tumour infiltration with natural killer cells. After microwave hyperthermia or IL-2 injection alone there was minimal T-cell infiltration, but T cells were more in evidence following combination therapy.
Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J
J
Nakayama
A
A
Urabe
K
K
Toyofuku
S
S
Taniguchi
Y
Y
Hori
D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D005455:Fluorescent Antibody Technique; D006358:Hot Temperature / Q000627:therapeutic use*; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000008:administration & dosage*; D007694:Killer Cells, Natural / Q000276:immunology; D008546:Melanoma, Experimental / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008872:Microwaves; D012878:Skin Neoplasms / Q000276:immunology / Q000628:therapy*
D007376:Interleukin-2