Predictors of short-term treatment response in 66 patients with panic disorder.
Short-term treatment response in panic disorder was studies in 66 subjects who had completed 3 weeks of treatment with fluvoxamine (n = 23), cognitive therapy (n = 20), or placebo (n = 23). Clinical and self-rated assessments were gathered at baseline, during, and after treatment. Using multiple logistic regression, treatment with fluvoxamine, a low panic attack severity score, and absence of a comorbid personality disorder were identified as significant predictors of recovery. Personality disorder was an important negative predictor to outcome with cognitive therapy. The results support the efficacy of fluvoxamine, and show that patients with low symptom severity and a normal personality respond well to treatment.
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
D W
DW
Black
R B
RB
Wesner
J
J
Gabel
W
W
Bowers
P
P
Monahan
D000293:Adolescent; D000328:Adult; D000368:Aged; D015928:Cognitive Behavioral Therapy; D004311:Double-Blind Method; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D010919:Placebos; D011336:Probability; D011379:Prognosis; D016896:Treatment Outcome
D010919:Placebos; D016666:Fluvoxamine