[Nerve regeneration under the influence of baliz-2 and laktovit].
Reparative processes in the sciatic nerve of rats were studied by histological methods after a cryogenic injury with a combined and separate action of drugs Lactovit and Balise-2. The animals were divided into 5 groups: I--intact animals; II--control animals; III--animals treated with Balise-2; IV--animals treated with Lactovit; V--animals treated with both Balise-2 and Lactovit. In the nerve trunk within 75 days after injury (the maximum period of observation) the amount of thick myelin fibers with a diameter 6.8 mkm in the second group was 18%, in the third group--36%, in the fourth group--40%, in the fifth group--48%. Balise-2 mainly influenced differentiation of nerve fibers, while Lactovit first increased growth of the axons and then accelerated their differentiation and myelinization. Joint application of the drugs resulted in convergence of positive effects which was expressed by the greatest degree of reparation of the nerve trunk in the animals of the fifth group as compared with control.
E I
EI
Chumasov
A Ia
AIa
Shurygin
S Iu
SIu
Soldatova
K M
KM
Svetikova
A I
AI
Drobyshevskiĭ
D016573:Agrochemicals / Q000494:pharmacology*; D000818:Animals; D006133:Growth Substances / Q000494:pharmacology*; D007651:Keto Acids / Q000494:pharmacology; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D009930:Organic Chemicals; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D016573:Agrochemicals; D006133:Growth Substances; D007651:Keto Acids; D009414:Nerve Growth Factors; D009930:Organic Chemicals; C088004:lactovit; C057854:baliz 2
Regeneratsiia nervov pod vliianiem baliza-2 i laktovita.