Prognostic factors in bladder cancer. A pathologic, immunohistochemical, and DNA flow-cytometric study.
Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlated with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy.
Unit of Anatomical Pathology, University of Cordoba, Spain.
A
A
Lopez-Beltran
G A
GA
Croghan
I
I
Croghan
A
A
Matilla
J F
JF
Gaeta
D000017:ABO Blood-Group System / Q000737:chemistry; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000097:blood / Q000401:mortality* / Q000473:pathology*; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology*
D000017:ABO Blood-Group System; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)