The pharmacology and the potential applications of GnRH antagonists.
Gonadotropin-releasing hormone (GnRH) antagonists are potent analogs of native GnRH. As biochemical probes, these recently developed compounds have allowed for profound insights into the physiology of the pituitary-ovarian and pituitary-testicular axes; as therapeutic alternatives, the GnRH antagonists hold great promise for various clinical applications, including contraception, ovulation induction, precocious puberty, and gonadal steroid-dependent neoplasia. Indeed, because of intrinsic mechanistic differences, the antagonists hold certain practical advantages over the GnRH agonists.
Center for Infertility and Reproductive Medicine, Orlando, Florida.
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D003271:Contraceptive Agents, Female / Q000627:therapeutic use; D003272:Contraceptive Agents, Male / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000502:physiology; D012099:Reproductive Techniques
D003271:Contraceptive Agents, Female; D003272:Contraceptive Agents, Male; D007987:Gonadotropin-Releasing Hormone