Erythropoietic suppression in fetal anemia because of Kell alloimmunization.
OBJECTIVE
Our purpose was to test the hypothesis that maternal anti-Kell alloimmunization produces fetal anemia by erythroid suppression.


METHODS
Erythropoiesis in 11 anemic fetuses from maternal anti-Kell alloimmunization was compared with that in 11 fetuses where the mother was alloimmunized to RhD; each was matched for hematocrit, gestational age, hydrops, and perinatal outcome. Comparisons of the difference were performed by either paired t or Wilcoxon tests.


RESULTS
The anti-Kell group had reduced reticulocytosis (p = 0.007) and erythroblastosis (p = 0.045) and lower amniotic fluid bilirubin concentrations (p = 0.02) in comparison with the anti-D group. No correlation was found between hematocrit and reticulocytosis in the anti-Kell group, whereas the anti-D group had a significant linear relationship (r = 0.63, p < 0.05), indicating a progressive reticulocytosis in response to the degree of anemia.


CONCLUSIONS
These findings suggest that erythroid suppression, rather than hemolysis, is the predominant mechanism in producing fetal anemia related to maternal Kell alloimmunization. Fetal blood sampling is the investigation of choice in the evaluation of anemia related to maternal Kell alloimmunization, because reduced hemolysis means amniotic fluid bilirubin concentrations correlate poorly with anemia.
Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
J I
JI
Vaughan
R
R
Warwick
E
E
Letsky
U
U
Nicolini
C H
CH
Rodeck
N M
NM
Fisk
D004899:Erythroblastosis, Fetal / Q000097:blood / Q000209:etiology* / Q000276:immunology; D004920:Erythropoiesis / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000502:physiology; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies; D007626:Kell Blood-Group System / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000276:immunology; D017701:Reticulocyte Count; D012203:Rh Isoimmunization / Q000097:blood
D007518:Isoantibodies; D007626:Kell Blood-Group System