The use of cell proliferation data in modeling of skin carcinogenesis.
A simple model for papilloma formation is used to analyze data from a mouse skin-painting experiment performed with NMRI mice. The results suggest that one of two conclusions may be drawn: Either the model fails to properly describe the growth behavior of papilloma cells or the model suggests that papilloma cells do not have growth advantage over normal cells, even during promotion.
Kopp-Schneider
A
A
Department of Biostatistics, German Cancer Research Center, Heidelberg.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D002455:Cell Division; D003043:Cocarcinogenesis; D007700:Kinetics; D016013:Likelihood Functions; D051379:Mice; D008954:Models, Biological; D010212:Papilloma / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate