[Experimental study of the characteristics of c-fos genetic expression in the neurons of visual cortex area 17 in amblyopic cats].
After the experimental kitten eyes were exposed to stimulation by the moving sinusoidal grating, the fos proteins, products of c-fos genetic expression in the nuclei of excited neurons in layer IV of the visual cortex area 17, were stained with the immunocytochemical ABC technique. The changes in number and grey scale of the c-fos immunopositive neurons of normal, monocular strabismic and monocular deprived eyes were processed by the computer image analysis system. The results indicated that (1) the PVEP of amblyopic cats was consistent with the dysplasia of visual cortex; and (2) the pathophysiologic defects in visual cortex of the amblyopic cats did have a molecular chemoneurological basis.
Shao
L G
LG
Institute of Radiation Medicine, Academy lf Military Medical Sciences, Beijing.
D000550:Amblyopia / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002415:Cats; D005074:Evoked Potentials, Visual; D016762:Genes, fos; D007091:Image Processing, Computer-Assisted; D009474:Neurons / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D014793:Visual Cortex / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos