The effect of low dose propofol for prevention of nausea and vomiting during spinal anesthesia for cesarean section.
In order to investigate the possible antiemetic property of propofol at subhypnotic dosage, fifty patients scheduled for elective cesarean section under spinal anesthesia were accepted into the study. Patients were randomly given intravenous propofol 10 mg (group I) or 1 ml intralipid (group II) after delivery of the infant. Overall incidence of nausea (24% in group I and 40% in group II) and vomiting (16% in group I and 20% in group II) were not statistically different in the two groups. However, onset time to the appearance of nausea and vomiting were longer in group I (14 +/- 5.8 min vs 5.4 +/- 3.6 min). In conclusion, low dose propofol (10 mg) administered during spinal anesthesia for cesarean section failed to reduce the incidence of emesis.
Shi
J J
JJ
Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.
Wang
Y P
YP
Sun
W Z
WZ
Hung
C P
CP
Cherng
Y G
YG
Lin
S Y
SY
Liu
C C
CC
D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009325:Nausea / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
D015742:Propofol