Hepatitis B vaccination in infants of mothers infected with human immunodeficiency virus.
Eighteen infants of mothers with human immunodeficiency virus (HIV) infection were given hepatitis B vaccine at birth. Seroconversion occurred in all 13 infants whose HIV antibody disappeared, versus one of five HIV-infected children. The four of five HIV-infected infants who did not mount an antibody response progressed rapidly to full-blown acquired immunodeficiency syndrome. Thus HIV-infected infants respond poorly to hepatitis B vaccine.
Fifth Pediatric Department, University of Milan, Italy.
G V
GV
Zuccotti
E
E
Riva
P
P
Flumine
V
V
Locatelli
A
A
Fiocchi
G
G
Tordato
M
M
Giovannini
D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D009035:Mothers
D015483:HIV Antibodies; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines