Age- and sex-related changes of sulfotransferase activities in the rat.
Temporal and gender-related changes of sulfotransferase activities in the rat were studied using alcoholic, amine and phenolic compounds as substrates. Alcohol and amine sulfotransferase activities in the rat exhibited different temporal and sex-related changes of those for phenol. Formation of sulfoconjugates in vivo correlated well with in vitro sulfotransferase activities in the rat liver.
Department of Pharmacokinetics and Drug Metabolism, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
K
K
Iwasaki
Y
Y
Tokuma
K
K
Noda
H
H
Noguchi
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015239:Arylsulfotransferase / Q000378:metabolism; D052160:Benzothiazoles; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D051381:Rats; D012727:Sex Characteristics; D013379:Substrate Specificity; D015238:Sulfotransferases / Q000378:metabolism*; D014018:Tissue Distribution / Q000187:drug effects
D052160:Benzothiazoles; D010879:Piperazines; C035773:RHC 3281; C003468:tiaramide; D015238:Sulfotransferases; D015239:Arylsulfotransferase; C028152:alcohol sulfotransferase; C035817:amine sulfotransferase