Mutagenicity of B(a)P in the presence of some hydralazine derivatives.
Hydralazine, dihydralazine and todralazine were tested in the aspect of their mutagenic potency, and the influence upon the mutagenicity of standard promutagen--B(a)P. Hydralazine exhibited strong mutagenic activity in the Ames test while mutagenic activity of dihydralazine was relatively weak. Todralazine had no mutagenic activity, and significantly decreased mutagenicity of B(a)P. It was concluded that todralazine could be a good antimutagenic substance.
Gasiorowski
K
K
Department of Basic Medical Sciences, Medical Academy, Wrocław, Poland.
Szyba
K
K
Sawicka
J
J
Gulanowski
B
B
D016587:Antimutagenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D004078:Dihydralazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006830:Hydralazine / Q000031:analogs & derivatives / Q000494:pharmacology*; D009152:Mutagenicity Tests; D014032:Todralazine / Q000494:pharmacology
D016587:Antimutagenic Agents; D006830:Hydralazine; D001564:Benzo(a)pyrene; D004078:Dihydralazine; D014032:Todralazine