[The classical Bowman-Birk soy inhibitor is an effective inhibitor of human granulocyte alpha-chymotrypsin and cathepsin G].
A kinetic study of the interaction of the classical Bowman-Birk type soybean inhibitor (BBI 2-IV) with human granulocyte alpha-chymotrypsin and cathepsin G has been carried out. The K(a) values for the inhibitor-proteinase systems--alpha-chymotrypsin and cathepsin G (2.0 x 10(5) and 6.4 x 10(6) M-1 s-1, respectively) have been established.
I P
IP
Gladysheva
N I
NI
Larionova
D P
DP
Gladyshev
T V
TV
Tikhonova
N F
NF
Kazanskaia
D000595:Amino Acid Sequence; D001665:Binding Sites; D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D012697:Serine Endopeptidases; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000494:pharmacology*
D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D002403:Cathepsins; D012697:Serine Endopeptidases; D002918:Chymotrypsin; C534094:CTSG protein, human; D056649:Cathepsin G
Klassicheskiĭ soevyĭ ingibitor tipa Baumana-Birk--éffektivnyĭ ingibitoralpha-khimotripsina i katepsina G granulotsitov cheloveka.