Adaptogenic and cardioprotective action of Galleria mellonella extract in rats and frogs.
Pharmacological and metabolic effects of Galleria mellonella larvae extract used in Russian folk medicine to treat cardiovascular and senile diseases were studied. It was shown that the extract possesses adaptogenic, cardiotropic, cardioprotective, and hypocoagulant properties. The extract possesses low toxicity and does not cause significant changes in biochemical parameters in the blood serum of laboratory animals. Increase in catecholamine content in the heart and aortic tissues and their decrease in adrenal glands are unfavourable effects of high doses of the extract.
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region.
A K
AK
Rachkov
N A
NA
Spiridonov
M N
MN
Kondrashova
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001001:Anura; D001777:Blood Coagulation / Q000187:drug effects; D004837:Epinephrine / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D066298:In Vitro Techniques; D007677:Kidney Function Tests; D009036:Moths / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects; D051381:Rats; D013328:Strophanthins / Q000037:antagonists & inhibitors / Q000633:toxicity; D014020:Tissue Extracts / Q000494:pharmacology*
D013328:Strophanthins; D014020:Tissue Extracts; D006003:Glycogen; C029082:strophanthin K; D009638:Norepinephrine; D004837:Epinephrine