An assessment of postnatal growth after in utero long bone osteotomy with fixation.
Researchers have recently suggested that rigid fixation of the immature bony skeleton may restrict growth and development. This study assesses the effect on postnatal growth of an in utero tibial osteotomy fixed with a miniplate in fetal sheep. A midshaft osteotomy was performed on fetal sheep tibia (n = 5) at 95 days' gestation (term 145 days). One tibia was reduced and fixed with a titanium miniplate and screws, while the contralateral hindlimb served as a control. The newborns were vaginally delivered and sacrificed at 2 months of age. The hindlimbs, control and fractured, were harvested, stripped of soft tissue, and the tibia, femur, and distal metatarsal were each measured and weighed. Each tibia also underwent radiographic analysis and histologic examination (after decalcification) using hematoxylin and eosin, Sirius red, and Alcian blue stains. No prenatal, postnatal, or perioperative medical complications occurred. Apart from a slight angulation in one operated tibia, no gross morphologic differences, either visible or palpable, were found between the operated and control limbs. This was confirmed radiographically where no remnant of the osteotomy site was visible. Measurements of the operated and control tibias, femurs, and metatarsal bones were not statistically different. Histologic analysis showed a total incorporation of bone at the osteotomy site with appositional growth present. All bone was lamellar with longitudinal orientation. In the area of the screw sites, the surrounding bone shaft was the same width as its neighboring bone.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
J A
JA
Goldstein
J C
JC
Posnick
M D
MD
Wells
R K
RK
Slate
P S
PS
Thorner
D000818:Animals; D000831:Animals, Newborn; D001860:Bone Plates; D001863:Bone Screws; D005260:Female; D005333:Fetus / Q000601:surgery*; D017102:Fracture Healing / Q000502:physiology; D006614:Hindlimb; D010027:Osteotomy / Q000379:methods; D011247:Pregnancy; D012756:Sheep; D013977:Tibia / Q000254:growth & development* / Q000473:pathology / Q000601:surgery; D013978:Tibial Fractures / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*