Pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques.
To determine whether age affects the pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques (Macaca nemestrina), dideoxyinosine (10 mg/kg of body weight) was administered as a single intravenous bolus to macaques at ages < 1 week, 1 month, and 4 months. Clearance from plasma at < 1 week of age was significantly lower (P < 0.05) and the terminal half-life was significantly higher than the corresponding values obtained at 1 month and 4 months of age. Our data indicate that the pharmacokinetics of dideoxyinosine change significantly with age in M. nemestrina.
Department of Pharmaceutics, University of Washington, Seattle 98195.
C M
CM
Pereira
C
C
Nosbisch
J D
JD
Unadkat
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D016049:Didanosine / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008254:Macaca nemestrina
D016049:Didanosine