Synthesis of 4-alkylpyrazoles as inhibitors of liver alcohol dehydrogenase.
Theoretical studies by shape analysis of the molecular electrostatic potential on the van der Waals surfaces of a set of 4-alkylpyrazoles predicted 4-isopentyl derivative as a good inhibitor of liver alcohol dehydrogenase. Thus, the new 4-isopentyl and the already known 4-octylpyrazole have been prepared by a novel route. The isopentyl derivative has been tested as inhibitor of horse liver alcohol dehydrogenase giving the result predicted by the theoretical studies.
Echevarría
A
A
Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Brazil.
Martín
M
M
Pérez
C
C
Rozas
I
I
D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D000818:Animals; D006736:Horses; D008099:Liver / Q000201:enzymology*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D011720:Pyrazoles; D000426:Alcohol Dehydrogenase