Intraductal tetracycline therapy for the treatment of chronic recurrent parotitis.
Chronic recurrent parotitis (CRP) is recurrent parotid inflammation with non-obstructive sialectasis. Therapies which produce acinar atrophy or remove the acini are effective in treating CRP. Parotidectomy, tympanic neurectomy, duct ligation, and radiation therapy have either a low success rate or a high risk of morbidity. Intraductal antibiotic instillation has been proposed as a possible method of treatment. We hypothesized that the cytotoxic effects of tetracycline could produce acinar atrophy. A double-blind experiment of intraductal tetracycline instillation was performed in ten rabbits. Acinar atrophy and acute inflammation were found in 40% of the tetracycline treated glands; controls had a complete absence of these histologic changes. These results support the use of tetracycline instillation to produce acinar atrophy and therefore, intraductal tetracycline may be an effective, low-risk therapy for CRP. The clinical features of CRP will be reviewed and therapeutic implications discussed.
Bowling
D M
DM
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
Ferry
G
G
Rauch
S D
SD
Goodman
M L
ML
D000328:Adult; D000818:Animals; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010309:Parotitis / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D010784:Photomicrography; D011817:Rabbits; D012008:Recurrence; D012469:Salivary Glands / Q000528:radiation effects / Q000648:ultrastructure; D012796:Sialography; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*
D013752:Tetracycline