Cutaneous and musculoskeletal features, diagnostic modalities, and immunopathology in sarcoidosis.
Soluble interleukin-2 receptor levels in serum may correlate with disease activity in sarcoidosis. T cells that accumulate within pulmonary sarcoid lesions may demonstrate downregulation of their T-cell receptor-CD3 complex. Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 appear to be increased in sarcoidosis and interact with various cell types to propagate the disease process. B cells appear to play a greater role in sarcoid pathogenesis than was earlier thought, as evidenced by enhanced products of humoral immune response (ie, immunoglobulins and immune complexes). Clinically, sarcoidosis may initially present with a variety of cutaneous manifestations. Both magnetic resonance imaging and ultrasonography may be useful in evaluating the presence of abdominal sarcoidosis. J001 scintigraphy may provide a new diagnostic technique in assessing pulmonary and lymph-node involvement in sarcoid.
Division of Rheumatology, Albany Medical College, NY 12208.
S D
SD
Fink
J M
JM
Kremer
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001847:Bone Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D009140:Musculoskeletal Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D016207:Cytokines