Mechanisms of erythropoietin signal transduction: involvement of calcium channels.
Erythropoietin (Epo) induces a dose-dependent increase in intracellular free calcium concentration ([Cai]) in single human BFU-E derived erythroblasts, which is specific for stage of differentiation and mediated through a voltage-independent ion channel permeable to calcium. This minireview examines the regulation of calcium channels by Epo during normal erythroid differentiation, as a model to delineate the immediate signaling events which follow interaction of Epo with its receptor.
Miller
B A
BA
Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Cheung
J Y
JY
D000818:Animals; D002118:Calcium / Q000097:blood; D015220:Calcium Channels / Q000502:physiology*; D002454:Cell Differentiation; D004900:Erythroblasts / Q000378:metabolism; D004921:Erythropoietin / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; D004921:Erythropoietin; D019204:GTP-Binding Proteins; D002118:Calcium