Molecular analysis of an asymptomatic Ph-positive CML patient with 27 years of prolonged remission.
We describe the results of clinical, cytogenetic, and molecular biological studies of a patient who, after two courses of treatment with Busulphan, has remained free of symptoms of Philadelphia chromosome-positive chronic myeloid leukemia for 27 years, except for the persistence of a Ph1 chromosome and the presence of its transcribed chimeric mRNA.
Amikam
D
D
Department of Molecular Genetics, Rambam Medical Center, Haifa, Israel.
Henig
C
C
Sharon
R
R
Tatarsky
I
I
Ben-Ishai
Z
Z
D000368:Aged; D002066:Busulfan / Q000627:therapeutic use; D002874:Chromosome Mapping; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D012074:Remission Induction; D012175:Retinoblastoma / Q000235:genetics; D013997:Time Factors
D004273:DNA, Neoplasm; D002066:Busulfan