[An early carcinoma of the gallbladder with atypical epithelium ( a report of a case with elevated p53 expression)].
The p53 tumor suppressor gene is believed to play an important role in the progression of malignant tumors through mutation and overexpression. The p53 protein and Ki-67 immmunochemistry were performed on an early gallbladder carcinoma with atypical epithelium. Overexpression of the protein was found in adenocarcinoma area with diffusely distributed positive cells (p53 index: 76 +/- 24%) and in atypical epithelial areas with foci of diffusely distributed positive cells (p53 Index: 30 +/- 14%), while the Ki-67 index was 6 +/- 4% in the adenocarcinoma areas and 6 +/- 2% in the atypical epithelial areas in each p53 measured corresponding areas. This suggest that p53 protein overexpression occurs in early carcinoma and/or atypical epithelium at least in some cases and that it is an early event in the development of gallbladder adenocarcinomas and also that the atypical epithelium may belong to carcinoma.
Departamento de A. Patológica, Hospital Nacional E. Rebagliati M., Lima, Perú.
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Yabar
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Watanabe
D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism; D000368:Aged; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53
Carcinoma temprano con epitelio atípico de vesícula biliar (reporte de un caso con expresión aumentada del p53).