[Changes in the functional activity of human neutrophils under the action of recombinant interleukin-2].
The effect of recombinant interleukin 2 (rIL-2) on the functional activity of human polymorphonuclear cells (neutrophils) was studied. The study revealed that the preliminary incubation of neutrophils with rIL-2 at a concentration of 10 I.U./ml for 30 minutes significantly enhanced the chemotaxis of neutrophils. In the presence of rIL-2 the tendency towards an increase (p > 0.05) in the spontaneous migration of neutrophils and in the intensity of their respiratory burst was observed. When used at concentrations of 100-1000 I.U./ml, rIL-2 inhibited the phagocytosis of Staphylococcus aureus, and at concentrations of 10 I.U./ml and greater it inhibited the bactericidal activity of neutrophils. The conclusion on the direct action of rIL-2 on the functional activity of human neutrophils was made.
Potapnev
M P
MP
Marinich
D V
DV
Pechkovskiĭ
D V
DV
Bortkevich
L G
LG
Maslovskaia
A M
AM
D001770:Blood Bactericidal Activity / Q000187:drug effects; D002469:Cell Separation; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology; D016897:Respiratory Burst / Q000187:drug effects
D007376:Interleukin-2; D011994:Recombinant Proteins
Izmenenie funktsional'noĭ aktivnosti neĭtrofilov cheloveka pod deĭstviem rekombinantnogo interleĭkina 2.