Unilateral damage to the ventral tegmental area facilitates feeding induced by stimulation of the contralateral ventral tegmental area.
Unilateral lesions of the ventral tegmental area (VTA) facilitated feeding induced by electrical stimulation of the homologous VTA tissue in the contralateral hemisphere. The lesions shifted the function relating latency to begin feeding to stimulation frequency to the left simultaneously causing a reduction of frequency threshold for feeding reaction. Facilitation of feeding was immediate (with a peak on the 2nd postlesion day) and in some animals persisted up to the end of the 2-week experimental period. No facilitation of VTA stimulation-induced feeding was found in the control animals in which comparable lesions were performed in the contralateral lateral hypothalamus or the antero-dorsal thalamus which suggests that the effect was site specific. Individual differences in the magnitude and duration of the facilitatory effect on feeding may be related to the variability in the medio-lateral localization of the lesions. The results are interpreted in terms of compensatory increase in the dopaminergic transmission and/or decrease of the GABA-ergic inhibitory tone in the contralateral hemisphere after unilateral lesion to the mesencephalic dopaminergic systems. A possible involvement of the noradrenergic transmission is also discussed.
Department of Animal Physiology, University of Gdańsk, Poland.
W
W
Trojniar
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M
Staszewska
D000704:Analysis of Variance; D000818:Animals; D001931:Brain Mapping; D004558:Electric Stimulation; D005247:Feeding Behavior / Q000502:physiology*; D007839:Functional Laterality; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques; D013681:Tegmentum Mesencephali / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*