Steroid hormone profile in postmenopausal women with ovarian cancer.
Raised levels of steroid hormones are not expected in postmenopausal women. Therefore, if detected in postmenopausal women with ovarian cancer, they must be assumed to be related to the presence of the tumour and, therefore, may be of use as tumour markers. Serum levels of CA125, progesterone, 17-hydroxyprogesterone, sex hormone binding globulin and oestradiol were measured in 44 postmenopausal women with ovarian cancer, postsurgery and prior to chemotherapy. The relationship between the four hormone levels, CA125, patient age, stage, residual disease after surgery and differentiation were tested using the Spearman and Kendall rank coefficients. A significant inverse association was found between CA125 and progesterone levels, and CA125 and 17-hydroxyprogesterone. A positive association between 17-hydroxyprogesterone and progesterone was also found, and positive correlations between stage and CA125, and residual disease and CA125 were confirmed.
Department of Biochemistry, Royal Marsden Hospital, London, U.K.
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ME
O'Brien
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M
Dowsett
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I
Fryatt
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Wiltshaw
D019326:17-alpha-Hydroxyprogesterone; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology; D017698:Postmenopause / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D012189:Retrospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D006908:Hydroxyprogesterones; D012738:Sex Hormone-Binding Globulin; D011374:Progesterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone