Behavioural impairment induced by calcitonin gene-related peptide (CGRP) antiserum in passive avoidance reflex in rats.
The effects of CGRP antiserum on passive avoidance behaviour were tested in rats. Intracerebroventricular (i.c.v.) administration of CGRP antiserum immediately after a single learning trial attenuated the passive avoidance responses when the animals were tested for 24 h retention. Significant decreases in avoidance latency were found at CGRP antiserum dilutions of 1:20 and 1:40. The data supported the assumption that endogenous brain CGRP may be a modulator in learning-associated memory processes.
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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Kovács
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Telegdy
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology*; D008297:Male; D051381:Rats
D007106:Immune Sera; D015740:Calcitonin Gene-Related Peptide