Possible pathogenic role of IgE in Henoch-Schönlein purpura.
The incidences of clinical and biological markers of atopy were investigated in 16 children with IgA nephropathy (IgAN) (group A) and in 22 with Henoch-Schönlein purpura nephritis (HSPN) (group B). The incidence of increased plasma IgE levels according to age-matched normal values was significantly higher in group B (17/22, 77%) than in group A (7/16, 44%) (P < 0.05). Although not significant, the incidences of positive RAST tests and of a history of typical atopic symptoms were also higher in group B [10/22 (45%) and 11/22 (50%), respectively] than in group A [4/16 (25%) and 5/16 (31%), respectively]. Moreover, IgE deposits were demonstrated by a peroxidase/anti-peroxidase method on cutaneous Langerhans and mast cells in 4 of 6 patients with HSPN. Thus immunoallergy might account, in some cases, for the cutaneous, intestinal and pulmonary signs observed in HSPN, but not in IgAN. We postulate stimulation of IgE-sensitized mast cells by specific antigens in the presence of IgA circulating immune complexes (CIC), release of vasoactive substances, increased capillary permeability and perivascular deposition of IgA CIC.
Paediatric Nephrology Unit, State University of Liège, Belgium.
J C
JC
Davin
G
G
Pierard
C
C
Dechenne
D
D
Grossman
J
J
Nagy
M
M
Quacoe
M
M
Malaise
M
M
Hall
F
F
Jansen
J M
JM
Chantraine
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D011695:IgA Vasculitis / Q000276:immunology* / Q000473:pathology; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D009393:Nephritis / Q000276:immunology*; D011852:Radioallergosorbent Test; D012867:Skin / Q000276:immunology
D000936:Antigen-Antibody Complex; D007073:Immunoglobulin E