Chronic lymphoproliferative disorders: classification and diagnosis.
The chronic lymphoproliferative disorders are morphologically, immunologically and clinically heterogeneous. Common features of these processes include T, B or natural killer cell immunophenotypes and terminal deoxy-nucleotidyl transferase negativity. The B cell lymphocytic disorders include B-chronic lymphocytic leukaemia, B cell prolymphocytic leukaemia, chronic lymphocytic leukaemia-prolymphocytic leukaemia, non-Hodgkin's lymphoma (including mantle cell lymphoma) in leukaemic phase, hairy cell leukaemia and splenic lymphoma with villous lymphocytes. The T cell chronic lymphoproliferative disorders include prolymphocytic leukaemia, adult T cell leukaemia-lymphoma, large granulated lymphocyte leukaemia and Sézary syndrome. Occasionally, a lymphocytic proliferation is encountered that does not satisfy the morphological or immunophenotypical criteria for any of the above categories. These processes are best left unclassified.
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Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota Hospital, MN 55455.
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D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D015463:Leukemia, Prolymphocytic / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D015461:Leukemia, Prolymphocytic, T-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000145:classification* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology; D012751:Sezary Syndrome / Q000145:classification / Q000175:diagnosis / Q000473:pathology
D014408:Biomarkers, Tumor