Assessment of the vitamin A status in lactating and nonlactating, nonpregnant Indonesian women by use of the modified-relative-dose-response (MRDR) test.
The vitamin A statuses of two groups of Indonesian women were compared by using the modified-relative-dose-response (MRDR) test: 1) lactating, nonpregnant women of lower socioeconomic status (n = 64) and 2) better-educated, premenopausal, nonpregnant, nonlactating women (n = 14). At times from 3 to 6 h after dosing, the mean ratio of dehydroretinol to retinol (DR/R) in the serum was approximately threefold higher in the lactating women than in the control group, eg, 0.109 +/- 0.073 and 0.034 +/- 0.015, respectively, at 5 h. At a provisional DR/R cutoff of 0.06, the vitamin A statuses of 70% of the lactating women and of 7% of the control women were judged to be inadequate. Only 7% of the variability in abnormal MRDR ratios could be attributed to body weight. Both abnormal and normal responses were highly reproducible when performed 0.5-3.25 mo after the first test.
Department of Food Science, Iowa State University, Ames 50011.
S A
SA
Tanumihardjo
Muherdiyantiningsih
D
D
Permaesih
A M
AM
Dahro
Muhilal
D
D
Karyadi
J A
JA
Olson
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007214:Indonesia; D007774:Lactation / Q000378:metabolism*; D015596:Nutrition Assessment; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D013383:Suburban Population; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000097:blood / Q000175:diagnosis*
C024366:vitamin A2; D014801:Vitamin A