Syntheses and immunological effects of thymic humoral factor-gamma 2 and its Phe7-substituted analogues.
Thymic humoral factor-gamma 2 and five analogues modified at position 7 with various phenylalanine derivatives were synthesized by a solid-phase method. The synthetic peptides were tested for their effects on the impaired blastogenic response of phytohaemagglutin-stimulated T-lymphocytes of uraemic patients with infectious diseases. The synthetic thymic humoral factor-gamma 2 enhanced the blastogenic response of T-lymphocytes in the blood of the two patients tested. Of the synthetic peptides, [4-fluoro-Phe7]thymic humoral factor-gamma 2 exhibited the most potent effect.
Kidney Research Laboratory, Kojinkai, Sendai, Japan.
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D000595:Amino Acid Sequence; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010649:Phenylalanine / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014511:Uremia / Q000276:immunology
D009842:Oligopeptides; C064563:thymic humoral factor gamma 2; D010649:Phenylalanine