The MLLT3 gene maps between D9S156 and D9S171 and contains an unstable polymorphic trinucleotide repeat.
MLLT3, one of the genes shown to be a translocation breakpoint partner for the acute lymphocytic leukemia (MLL) gene, has been mapped to 9p22. We have identified a polymorphic trinucleotide repeat within this gene that shows somatic instability. The inheritance pattern of this polymorphism in recombinant individuals from families previously typed for other chromosome 9 markers indicates that the gene lies in the interval bounded by D9S156 and D9S171.
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Herston, Australia.
G J
GJ
Walker
M K
MK
Walters
J M
JM
Palmer
N K
NK
Hayward
D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D017931:DNA Primers; D005006:Ethnicity / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D014178:Translocation, Genetic
D017931:DNA Primers; D005819:Genetic Markers