Early peroxidizing effects of myocardial damage in rats after gamma-irradiation and farmorubicin (4'-epidoxorubicin) treatment.
Changes in lipid peroxide levels (TBA-RS) in rat serum and heart tissue as well as creatine kinase enzyme (CPK) activity in serum were used as early indicators of peroxidizing effects of heart damage after fractionated gamma-irradiation (4 x 5 Gy) and/or farmorubicin (4 x 2.5 mg/kg) treatment. An increase in the TBA-RS and enzyme activity was observed after the action of both agents given separately or in combination. The maximal expression of biochemical effects appeared a few days after irradiation or farmorubicin treatment. The application of the antioxidant, vitamin E, diminished the level of TBA-RS in serum and in heart homogenates plus CPK activity in serum, indicating the involvement of peroxidizing mechanisms in myocardial damage by both agents.
Laboratory of Radiobiology, Institute of Oncology, Gliwice, Poland.
W M
WM
Przybyszewski
M
M
Widel
A
A
Koterbicka
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D015251:Epirubicin / Q000633:toxicity*; D005260:Female; D005720:Gamma Rays; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats
D015251:Epirubicin; D003402:Creatine Kinase