Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
Sho-saiko-to (SST) and Juzen-taiho-to (JTT), Japanese modified Chinese herbal prescriptions, suppressed the activities of thymidylate synthetase and thymidine kinase involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively, in mammary tumors of SHN mice with the reduction of serum prolactin level. These results indicate that SST and JTT may have the antitumor effects on mammary tumors.
Medical Research Institute, Tokyo Medical and Dental University, Japan.
S
S
Sakamoto
R
R
Furuichi
M
M
Matsuda
H
H
Kudo
S
S
Suzuki
Y
Y
Sugiura
K
K
Kuwa
M
M
Tajima
M
M
Matsubara
H
H
Namiki
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D011388:Prolactin / Q000097:blood; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal; C063587:juzentaihoto; C018142:saiko-keishi-to; D011388:Prolactin; D013940:Thymidylate Synthase; D013937:Thymidine Kinase