Reversal of graft-versus-host disease with infusion of autologous bone marrow.
Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 x 10(8) and 1.6 x 10(8) autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.
Ricordi
C
C
University of Pittsburgh Transplantation Institute, PA 15213.
Tzakis
A G
AG
Zeevi
A
A
Rybka
W B
WB
Demetris
A J
AJ
Fontes
P A
PA
Nalesnik
M A
MA
Trucco
M
M
Ukah
F O
FO
Ball
E D
ED
D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006086:Graft vs Host Disease / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007890:Leiomyosarcoma / Q000601:surgery; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology; D013274:Stomach Neoplasms / Q000601:surgery; D013997:Time Factors; D014182:Transplantation, Autologous / Q000276:immunology