Alkalisation of lignocaine-adrenaline reduces the amount of pain during subcutaneous injection of local anaesthetic.
A double blind, randomised controlled trial was performed to compare the amount of pain experienced after subcutaneous infiltration of lignocaine with adrenaline, and the same anaesthetic buffered to pH 7.1-7.3, in patients undergoing liposuction (n = 8), blepharoplasty (n = 7), mammaplasty (n = 6), and in volunteers (n = 10). A linear analogue pain scale was used to access pain. In all four groups the buffered solution caused significantly less pain (p < 0.001 except for mammaplasty--p = 0.02).
Department of Plastic Surgery, Norwegian National Hospital, Oslo.
F
F
Samdal
K
K
Arctander
K C
KC
Skolleborg
P F
PF
Amland
D000328:Adult; D000368:Aged; D000772:Anesthesia, Local; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007279:Injections, Subcutaneous / Q000009:adverse effects*; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement
D008012:Lidocaine; D004837:Epinephrine