Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699.
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Deng
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Dene
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D000818:Animals; D001483:Base Sequence; D001794:Blood Pressure; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics; D002874:Chromosome Mapping; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats / Q000235:genetics*; D011921:Rats, Inbred WKY; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics
D017871:Calcium-Calmodulin-Dependent Protein Kinases; D000254:Sodium-Potassium-Exchanging ATPase