Mineral apposition rates of human cancellous bone at the interface of porous coated implants.
Human cancellous bone ingrowth studies were conducted on 19 consenting bilateral total knee arthroplasty (TKA) patients. Titanium porous coated cylinders were implanted into the medial femoral condyle of the contralateral knee during the first of two TKAs. Retrieval was performed at the time of the second TKA (6-131 weeks later), and fluorochrome analysis was conducted. Mean mineral apposition rates (MAR) at the interface measured 1.0 micron/day, whereas 4 mm away, the peripheral bone had a mean MAR of 0.8 micron/day. This represented a 25% acceleration in the interface bone remodeling rate when compared with the periphery (P < .05). This study showed the bone advanced appositionally at the interface at a rate of approximately 1 micron/day. Analysis showed that when bone was over 50 microns from the porous coating, bone ingrowth did not occur. These results emphasize the need for surgical precision and careful postoperative management to achieve bone ingrowth.
Bone and Joint Research Laboratory, VA Medical Center, UT 84148.
R D
RD
Bloebaum
K N
KN
Bachus
N G
NG
Momberger
A A
AA
Hofmann
D000368:Aged; D000369:Aged, 80 and over; D000497:Alloys; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology*; D016062:Porosity; D013997:Time Factors; D014025:Titanium
D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium