Midazolam/propofol but not propofol alone reversibly depress the swallowing reflex.
General anaesthetics depress swallowing and this is a reason to delay oral intake after general anaesthesia. The swallowing reflex was studied 2 h after general anaesthesia for patients undergoing colonoscopy. Forty-one patients were anaesthetized with midazolam 75 micrograms.kg-1 followed by a continuous infusion of propofol and 39 patients with propofol 1.5 mg.kg-1 bolus followed by an infusion. Swallowing reflex was measured by electromyography 2 h after induction of anaesthesia, before and 5 min after the administration of flumazenil (0.2 mg) or placebo. Two h after anaesthesia, the state of consciousness was almost normal in all patients and did not change after flumazenil. At two hours, the latency times for the swallowing reflex in patients treated with propofol alone were of 1.4 +/- 0.4 s and were significantly shorter (P < 0.05) than the value of 1.9 +/- 0.8 s observed in patients who received midazolam with propofol. In the latter group the latency time of the swallowing reflex was significantly reduced following the administration of flumazenil but not placebo. In patients who received propofol without midazolam, the administration of flumazenil or placebo was not associated with significant changes in the latency times. There were also no significant differences in the latency times in the subgroup that received midazolam followed by flumazenil and the propofol alone groups that did or did not receive flumazenil. These results suggest that midazolam still exerts a depressive effect on the swallowing reflex 2 h after its administration despite the recovery of normal consciousness.
Department of Anaesthesia, University Paris 12-Henri Mondor Hospital, Creteil, France.
G
G
D'Honneur
J M
JM
Rimaniol
A
A
el Sayed
Y
Y
Lambert
P
P
Duvaldestin
D000553:Ambulatory Care; D000771:Anesthesia, Intravenous; D001364:Awareness; D003113:Colonoscopy; D003679:Deglutition / Q000187:drug effects*; D003864:Depression, Chemical; D004311:Double-Blind Method; D004338:Drug Combinations; D004576:Electromyography / Q000187:drug effects; D005442:Flumazenil / Q000494:pharmacology; D006801:Humans; D006928:Hyoid Bone / Q000187:drug effects; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D010919:Placebos; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*
D004338:Drug Combinations; D010919:Placebos; D005442:Flumazenil; D008874:Midazolam; D015742:Propofol