Fever and leukocytosis related to terconazole vaginal suppository.
We describe a 22-year-old woman who developed fever, shaking chills, and leukocytosis after insertion of a terconazole (80 mg) vaginal suppository for mild vaginal candidiasis. The patient became afebrile and asymptomatic 24 hours after hospital admission without antibiotic therapy. More experience with terconazole is needed before it can be considered as safe as other imidazole derivatives that have been available for more than 15 years.
Department of Medicine, Polyclinic Medical Center, Harrisburg, PA 17100.
S S
SS
Hyder
J E
JE
Manjon
N M
NM
Gantz
D000282:Administration, Intravaginal; D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects*; D002177:Candidiasis / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced*; D013488:Suppositories; D014230:Triazoles / Q000009:adverse effects*
D000935:Antifungal Agents; D013488:Suppositories; D014230:Triazoles; C037815:terconazole