[The significance of endothelial injury in the pathogenesis of coronary heart disease].
In this study, the number of circulating endothelial cells (CEC) was counted and used as an indicator of the injury of vascular endothelial cells (VEC) in 27 cases with coronary heart disease (CHD), in vivo, CECs were identified with fluorescein-labeled anti-human antibody to factor VIII related antigen. The contents of MDA representing lipid peroxides were also measured in these cases. Meanwhile the number of CEC in normal people was counted as control and compared with that in patients before and after therapy. The results were as follows: The number of CEC and content of MDA in the patients were higher than that in normal people and these two induces were significantly correlated (r = 0.802). The CEC number reflects the severity of CHD. The present investigation suggests that VEC injury induced by the lipid peroxide may play an important role in the pathogenesis of the CHD and CEC counting can be used as a reference for judging the severity and the prognosis of the CHD.
Yang
L X
LX
Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing.
Zhu
S J
SJ
D000368:Aged; D002452:Cell Count; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged
D008315:Malondialdehyde