[A morphological and immunofluorescent study of the measles vaccinal process in an experiment on monkeys].
A correlation between localization of morphological lesions and the presence of viral antigen in the CNS was established. Dissemination of the infectious process in the CNS depended on both topography of the inoculated areas and more so on traumatic injury of the ventricular system. Viral antigen could be detected in the reticuloendothelial system and epithelial cells of the respiratory tract without inducing specific cytopathic changes. Simultaneous morphological and immunofluorescent examination allowed the safety of live measles vaccine to be established more accurately.
Maksimova
O A
OA
Popov
V F
VF
Grigor'eva
L V
LV
Sharova
O K
OK
Iunasova
T N
TN
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002490:Central Nervous System / Q000276:immunology / Q000648:ultrastructure; D002522:Chlorocebus aethiops; D005455:Fluorescent Antibody Technique; D008457:Measles / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D008458:Measles Vaccine / Q000276:immunology*; D008854:Microscopy, Electron
D000914:Antibodies, Viral; D008458:Measles Vaccine
Morfologicheskoe i immunofliuorestsentnoe issledovanie korevogo vaktsinal'nogo protsessa v éksperimente na obez'ianakh.