Toenail selenium levels and the risk of breast cancer.
The association between toenail selenium and breast cancer was studied in a prospective study on diet and cancer among 62,573 Dutch women aged 55-69 years that started in September 1986. The analysis was based on 355 breast cancer cases, detected during 3.3 years of follow-up (1986-1989), for whom selenium data were available. Selenium levels were significantly lower among cases diagnosed early during follow-up. After exclusion of cases that occurred in the first year of follow-up, multivariable-adjusted rate ratios of breast cancer in increasing quintiles of selenium were 1.00, 0.90, 0.76, 0.86, and 0.91 (trend p = 0.618). The authors found no evidence for an inverse association between selenium status and breast cancer.
Department of Epidemiology, University of Limburg, Maastricht, The Netherlands.
P A
PA
van den Brandt
R A
RA
Goldbohm
P
P
van't Veer
P
P
Bode
E
E
Dorant
R J
RJ
Hermus
F
F
Sturmans
D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D004034:Diet Surveys; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009262:Nails / Q000737:chemistry*; D009426:Netherlands / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012643:Selenium / Q000032:analysis*; D014034:Toes
D012643:Selenium