Investigation of the nucleolar organizer regions in Alzheimer's disease.
The Ag-stained nucleolus organizer regions and the satellite association (SA) were studied in peripheral lymphocyte cultures derived from 10 patients with Alzheimer's disease (AD), 10 elderly controls and 10 young controls. Our results showed a significant lower frequency of Ag staining and SA in relation to the chromosome pair 21 in the AD patient group when compared with the elderly and young control groups. These results point to a reduction in the activity of ribosomal genes in the AD patient group.
Departamento de Morfologia, Escola Paulista de Medicina, São Paulo, Brasil.
S L
SL
Payão
M
M
Smith
M H
MH
Kormann-Bortolotto
J
J
Toniolo
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D002871:Chromosome Banding; D002891:Chromosomes, Human, Pair 21; D004275:DNA, Ribosomal / Q000235:genetics; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D009697:Nucleolus Organizer Region / Q000473:pathology*; D012016:Reference Values
D004275:DNA, Ribosomal; D004276:DNA, Satellite