The potential role of inflammatory and fibrogenic cytokines in the glomerular diseases.
In recent years increasing evidence has been accumulated on the role of cytokines in mediating glomerular and renal damage. Many such cytokines are released in the inflamed glomeruli by leukocytes and intrinsic glomerular cells. Cytokines not only recruit inflammatory cells into the injured glomeruli, but also induce a variety of responses on glomerular cells that range from a direct toxic effect to shape changes, proliferation, and induction of the release of inflammatory mediators and extracellular matrix, and could promote further glomerular damage. Moreover, exogenous administration of cytokines has induced glomerular injury in healthy animals and has enhanced renal damage in animals with glomerulonephritis. Anti-cytokine strategies have proved to be effective therapeutical alternatives in experimental models of glomerular diseases and may provide a more specific approach to the management of human glomerulonephritis.
Laboratorio de Nefrología, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
A
A
Ortiz
M
M
Gómez-Chiarri
J
J
Alonso
C
C
Bustos
C
C
Gómez-Guerrero
M J
MJ
López-Armada
D
D
Gómez-Garre
I
I
Palacios
M
M
Ruíz-Ortega
S
S
Gutierrez
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D005920:Glomerular Mesangium / Q000276:immunology / Q000378:metabolism; D005921:Glomerulonephritis / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007249:Inflammation; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology; D015850:Interleukin-6 / Q000494:pharmacology / Q000502:physiology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000494:pharmacology / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha