Involvement of nitric oxide-formation in the action of losartan (DuP 753): effects in an inhibitory avoidance model.
The potent and selective orally active ANG II receptor antagonist losartan (DuP 753) enhanced the retentions in an inhibitory (passive) avoidance test after scopolamine amnesia. In addition, the influence of the specific NO-synthase inhibitor NG-nitro-L-arginine (L-NNA) in combination with losartan was tested. L-NNA itself shows no effect. The combination of losartan with L-NNA did not produce any prolongation of step-through latencies.
Hock
F J
FJ
Pharmaceutical Division, HOECHST AG Frankfurt/M., FRG.
D000804:Angiotensin II / Q000502:physiology; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000502:physiology; D007093:Imidazoles / Q000494:pharmacology*; D019808:Losartan; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D019335:Nitroarginine; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011945:Receptors, Angiotensin / Q000502:physiology; D013777:Tetrazoles / Q000494:pharmacology*
D057911:Angiotensin Receptor Antagonists; D001713:Biphenyl Compounds; D007093:Imidazoles; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D019808:Losartan