Bioavailability of inorganic arsenic from bog ore-containing soil in the dog.
In some parts of The Netherlands, bog ore-containing soils predominate, which have natural arsenic levels that exceed, by a factor of 10, existing standards for maximum allowable levels of inorganic arsenic in soil. These standards are based on the assumption that in humans the bioavailability of arsenic from ingested soil is equal to that from an aqueous solution. In view of the regulatory problem that the arsenic levels of these soils present, we questioned the validity of this assumption. To obtain a more realistic estimate, the bioavailability of inorganic arsenic from soil in a suitable animal model was studied. In this report, a study performed in six dogs in a two-way cross-over design is presented. The dogs received orally, in random order, arsenic both as an intravenous solution and as arsenic-containing soil. During a 120-hr period after administration urine was collected in 24-hr fractions. Levels of arsenic were determined using a method of wet digestion, isolation and complexation of arsine, followed by molecule absorption spectrometry. Within 120 hr after intravenous administration, 88 +/- 16% of the dose was excreted renally. After oral administration of arsenic-containing soil, only 7.0 +/- 1.5% was excreted renally. From the urinary excretion data for these two routes of administration, the calculated bioavailability of inorganic arsenic from soil was 8.3 +/- 2.0%. The results from this study demonstrate the need to reconsider the present risk assessment for arsenic in soil.
Unit Biotransformation, Pharmacokinetics and Toxicokinetics, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
K
K
Groen
H A
HA
Vaessen
J J
JJ
Kliest
J L
JL
de Boer
T
T
van Ooik
A
A
Timmerman
R F
RF
Vlug
D000818:Animals; D001151:Arsenic / Q000493:pharmacokinetics*; D001682:Biological Availability; D004285:Dogs; D005260:Female; D008297:Male; D012307:Risk Factors; D012989:Soil Pollutants / Q000493:pharmacokinetics*
D012989:Soil Pollutants; D001151:Arsenic