Long-term in vivo study of plasma-sprayed coatings on titanium alloys of tetracalcium phosphate, hydroxyapatite and alpha-tricalcium phosphate.
In order to study the interaction of calcium phosphate coatings with bone tissue, coated titanium plugs of standard size were implanted in dog femora. The bone bonding and bone formation of hydroxyapatite, alpha-tricalcium phosphate (alpha-TCP) and tetracalcium phosphate plasma-sprayed coatings were evaluated by mechanical push-out tests and histological observations after 3, 5, 15 and 28 months of implantation. During this time all coating types degraded. alpha-TCP showed the most significant degradation after 3 months of implantation. Hydroxyapatite and tetracalcium phosphate showed significant signs of degradation after about 5 months of implantation. All coatings showed a small increase in bone bonding after 5 months of implantation. In general, all types of implants showed similar bone response, some bone contact and several remodelling lacunae along the surfaces after long-term implantation.
Klein
C P
CP
Department of Oral Implantology, ACTA-Free University, Amsterdam, The Netherlands.
Patka
P
P
Wolke
J G
JG
de Blieck-Hogervorst
J M
JM
de Groot
K
K
D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism* / Q000633:toxicity; D001673:Biodegradation, Environmental; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000473:pathology / Q000601:surgery*; D002130:Calcium Phosphates / Q000378:metabolism* / Q000633:toxicity; D004285:Dogs; D017886:Durapatite / Q000378:metabolism* / Q000633:toxicity; D019736:Prostheses and Implants / Q000009:adverse effects; D014025:Titanium / Q000378:metabolism* / Q000633:toxicity
D000497:Alloys; D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous