Atrial natriuretic factor in the ischemic heart.
The synthesis and the release of the atrial natriuretic factor (ANF) were studied by electron microscopy in the atrial cells from an ischemic myocardium. The ANF-containing secretory vesicles of normal atrial cells were present in great number near the Golgi apparatus, and near the sarcolemma. After 30 min. of global ischemia the number of ANF-containing secretory vesicles decreased in the atrial cells, suggesting an ANF release during heart ischemia.
Department of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
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Ionescu
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Onicescu
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Muşat
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Trifan
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
D009320:Atrial Natriuretic Factor