The efficacy of anti-serotoninergic agents in the treatment of erectile dysfunction.
We investigated 3 agents with antiserotoninergic activity (oral trazodone, ketanserin and mianserin) in a double-blind randomized placebo controlled design in terms of the effectiveness in erectile dysfunction. Positive response rates to 30 days of treatment were 65.2% with trazodone, 19.1% with ketanserin, 31.6% with mianserin and 13.6% with placebo. Response to trazodone treatment was significantly better than with placebo (p = 0.0004) and the other 2 agents (p = 0.03 and p = 0.002 for mianserin and ketanserin, respectively). The effectiveness of ketanserin and mianserin seemed to be greater than that of placebo but the differences did not reach statistical significance (p = 0.63 and p = 0.17, respectively).
Urology Clinic, Ministry of Health of Ankara Hospital, Turkey.
U
U
Kurt
H
H
Ozkardeş
U
U
Altuğ
C
C
Germiyanoğlu
M
M
Gürdal
D
D
Erol
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D014196:Trazodone / Q000627:therapeutic use*
D008803:Mianserin; D007650:Ketanserin; D014196:Trazodone