Paraplegia and squamous cell carcinoma of the bladder in young women: findings from a case-control study.
A death certificate-based case-control study was conducted on 207 women aged 25-44 who died of bladder cancer in England and Wales in the period 1971-89 and 411 controls matched on sex, year of death and age at death. An odds ratio of 12.0 (95% CI 1.5-99.7) was found for women with a history of paraplegia. Four of the six paraplegic women were reported to have had squamous cell carcinoma of the bladder compared with only 19 of the 201 non-paraplegic women. These findings suggest that squamous cell carcinomas of the bladder, especially in paraplegics, may be the result of chronic urinary tract infection.
Dolin
P J
PJ
Cancer Epidemiology Unit, Imperial Cancer Research Fund, Radcliffe Infirmary, Oxford, UK.
Darby
S C
SC
Beral
V
V
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D016022:Case-Control Studies; D016001:Confidence Intervals; D003644:Death Certificates; D004739:England; D005260:Female; D006801:Humans; D016555:Matched-Pair Analysis; D016017:Odds Ratio; D010264:Paraplegia / Q000150:complications*; D001749:Urinary Bladder Neoplasms / Q000209:etiology*; D014552:Urinary Tract Infections / Q000150:complications / Q000209:etiology; D014852:Wales