Lipidized meningothelial tumor cells in "xanthomatous" meningioma express macrophage antigen.
A case of "xanthomatous" meningioma was examined by light and electron microscopy as well as immunohistology. Lipid-laden "xanthomatous" cells were shown to be meningothelial by all ultrastructural criteria. All tumor cells (lipidized and non-lipidized) expressed vimentin in their cytoplasm, but only the lipidized cells showed the presence of the macrophage marker HAM-56. This finding suggests that, as in some other areas of general pathology, immunological markers may serve as indicators of a specific activity (in this case phagocytosis), rather than merely histogenesis.
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160-7410.
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Kepes
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008577:Meningeal Neoplasms / Q000276:immunology / Q000473:pathology*; D008579:Meningioma / Q000276:immunology / Q000473:pathology*; D014973:Xanthomatosis / Q000276:immunology / Q000473:pathology*
D000951:Antigens, Neoplasm