Negative ANCA in Wegener's granulomatosis.
Wegener's granulomatosis is a systemic vasculitis characterized by necrotizing granulomata and without treatment is associated with a poor prognosis. Antineutrophil cytoplasmic antibodies (ANCA) have proved to be a useful serological marker allowing for early diagnosis and treatment of this condition. We report two cases of patients who were ANCA-negative on presentation despite clinical suspicion of Wegener's granulomatosis. In both cases the patients developed a positive ANCA titre as the disease progressed.
Carrie
S
S
Department of Otolaryngology, Doncaster Royal Infirmary.
Hughes
K B
KB
Watson
M G
MG
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D001301:Audiometry, Pure-Tone; D001323:Autoantibodies / Q000032:analysis*; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D006312:Hearing Loss, Bilateral / Q000503:physiopathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D012698:Serologic Tests; D013997:Time Factors
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G