Disseminated coccidioidomycosis associated with extreme eosinophilia.
Primary coccidioidomycosis is frequently accompanied by eosinophilia in the range of 5%-10% of the peripheral white blood cell count. Dissemination of Coccidioides immitis to organs such as skin, bone, joints, and CNS usually is associated with risk factors such as sex (male), race (non-Caucasian), pregnancy, and immunosuppression. We report a case of coccidioidomycosis in an otherwise healthy African-American man with 72% eosinophilia who had dissemination to the skin, and we review cases in the literature of disseminated disease associated with eosinophilia. Marked eosinophilia may be an important early clue that dissemination of coccidioidomycosis has occurred.
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605.
W B
WB
Harley
M J
MJ
Blaser
D000328:Adult; D015415:Biomarkers; D003047:Coccidioidomycosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D003881:Dermatomycoses / Q000097:blood / Q000150:complications / Q000175:diagnosis; D004802:Eosinophilia / Q000097:blood / Q000150:complications*; D006801:Humans; D007958:Leukocyte Count; D008172:Lung Diseases, Fungal / Q000097:blood / Q000150:complications / Q000175:diagnosis; D008297:Male
D015415:Biomarkers