[Realities and limitations of the diagnosis of erectile impotence: radical urethro-prostato-cystectomy as a human experimentalmodel].
Veno-occlusive dysfunction (formerly called "venous leakage") is a clinical-radiographic manifestation of a multi-aetiology syndrome, the pathogenesis of which is to be sought in intrinsic damage to the erectile tissue. It has been attributed to psycho-neurogenic, neurovascular and local--physical factors. The unsatisfactory results of the various surgical techniques proposed (venous ligatures, crural plication, corporopexy) can be explained by the formation of vicarious venous circles, a phenomenon which occurs regardless of the type of procedure adopted and which is the direct consequence of the alteration of the occlusive mechanisms intrinsic to the erectile tissue. At the Urological Institute of the University of Milan, a study has been carried out with the aim of experimentally assessing these aetiopathogenetic hypotheses. 48 sexually potent patients were selected from those scheduled for extensive surgical procedures on account of malignant pathologies of the pelvic cavity (urethro-prostato-cystectomy, radical prostatectomy). The protocol included a series of examinations before and after the operation (at three months): computerised recording of nocturnal erections (NPT test, three consecutive nights), dynamic penile Doppler velocimetry, dynamic cavernosometry/graphy, examination of bulbocavernosus reflex. The goal of the study was to evaluate the haemodynamic consequences of the massive venous ligatures effected during these operations (periprostatic plexus, deep dorsal vein, spongio-cavernous connections). There were 28 cases of radical prostatectomy and 20 cases of radical urethro-prostato-cystectomy. Among the cases of radical prostatectomy, the extrafascial retropubic technique was used for 14 patients, the monolateral nerve-sparing procedure was applied for 10 patients (stage B1) and the transperineal approach was used for 4 patients (the most recent).(ABSTRACT TRUNCATED AT 250 WORDS)
Istituto di Urologia dell'Università di Milano.
E
E
Austoni
F
F
Colombo
F
F
Mantovani
P
P
Zanetti
O
O
Fenice
L
L
Canclini
G
G
Mastromarino
D
D
Vecchio
D003097:Collateral Circulation; D015653:Cystectomy / Q000009:adverse effects* / Q000379:methods; D007172:Erectile Dysfunction / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007001:Hypogastric Plexus / Q000293:injuries; D010535:Laparoscopy; D008026:Ligation / Q000009:adverse effects; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D010410:Penile Erection / Q000502:physiology; D010413:Penis / Q000098:blood supply / Q000000981:diagnostic imaging / Q000294:innervation; D011183:Postoperative Complications; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods; D011859:Radiography; D012021:Reflex, Abnormal; D012039:Regional Blood Flow; D014463:Ultrasonography; D014521:Urethra / Q000601:surgery*; D014565:Urogenital Neoplasms / Q000601:surgery; D014680:Veins / Q000293:injuries
Attualità e limiti della diagnostica nell'impotenza erettile: la uretro-prostato-cistectomia radicale come modello sperimentale umano.