Chrymutasins: novel-aglycone antitumor antibiotics from a mutant of Streptomyces chartreusis. I. Taxonomy, mutation, fermentation, isolation and biological activities.
Three novel antibiotics, named chrymutasins A, B and C, were isolated from the fermentation products of a mutant strain obtained by NTG (N-methyl-N'-nitro-N-nitrosoguanidine) treatment. The mutant strain produced the chrymutasins, which differed in the aglycone moiety from chartreusin, and related compounds. The production of these compounds needed a characteristically long fermentation period. The antitumor activity of chrymutasin A is better in vivo than that of chartreusin, the cytotoxic activity against cell lines in vitro is equivalent, and the antimicrobial spectrum is narrower.
Pharmaceutical Research Laboratories, Sapporo Breweries Ltd., Shizuoka, Japan.
H
H
Uchida
Y
Y
Nakakita
N
N
Enoki
N
N
Abe
T
T
Nakamura
M
M
Munekata
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D016296:Mutagenesis; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013302:Streptomyces / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015003:Yeasts / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D006027:Glycosides; C088439:chrymutasin A; C088440:chrymutasin B; C088441:chrymutasin C