[The role of endotoxin in the bronchial hyperreactivity formation].
Endotoxin was as a pathogen to investigate its effects on bronchial hyperreactivity formation. The latent periods of guinea pigs inhaled histamine and PD2 value of isoproterenol were markedly decreased 4 days after the intraperitoneal injection of endotoxin 1 mg/kg, meanwhile PD2 value of histamine and histamine levels of lung tissue and plasma were increased significantly. These results indicate that endotoxin is a very important factor in the infection induced bronchial hyperreactivity.
Chen
J X
JX
Department of Pharmacology, Hengyang Medical College.
Wu
H X
HX
Wang
Y
Y
D000818:Animals; D016535:Bronchial Hyperreactivity / Q000139:chemically induced*; D004731:Endotoxins; D004926:Escherichia coli; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007545:Isoproterenol / Q000494:pharmacology; D008070:Lipopolysaccharides; D008168:Lung / Q000378:metabolism; D008297:Male
D004731:Endotoxins; D008070:Lipopolysaccharides; D006632:Histamine; D007545:Isoproterenol