[The negative chronotropic effect of isorhynchophylline and its mechanism].
Isorhynchophylline (2-4 mg/kg i.v.) can produce a negative chronotropic effect in rats without influencing blood pressure. This negative chronotropic effect has nothing to do with cardiac M, beta and H2 receptors, but may be related to the block of calcium.
Zhu
Y
Y
Zunyi Medical College.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002122:Calcium Chloride / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D008297:Male; D000078183:Oxindoles; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; D002121:Calcium Channel Blockers; D026121:Indole Alkaloids; D000078183:Oxindoles; C052714:rhyncophylline; D002122:Calcium Chloride