Derivatives of 2-mercaptobenzenesulphonamide. XII. Synthesis and some pharmacological properties of 2-(2-mercaptobenzenesulphonyl)imidazoline.
Synthesis of 2-[2 (alkylaminoalkylthio)-4-R1-5-R2-benzenesulphonamide]-5-R3-im idazoline [IV-IX], their hydrochlorides [IVa-IXa], as well needful substrates [IIc, III] are described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of compound IVa-IXa are presented. Some structure-activity relationship is also discussed.
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
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Z
Brzozowski
J
J
Sławiński
K
K
Oledzka
M
M
Kosmala
K
K
Lewandowski
M
M
Filczewski
J
J
Miłobedzka
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D008970:Molecular Weight; D051381:Rats; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D013449:Sulfonamides