[The immunomodulating action of bestatin in the combined therapy of bladder cancer patients].
A beneficial effect of bestatin used as adjuvant in the course of chemo- and radiotherapy of local cancer of the bladder manifested itself as a reduction of postradiation immunosuppression: increased count of T mu-helper/inductors and T gamma-suppressors/killers, enhancement of neutrophil phagocytic activity. Bestatin recovers radiation-impaired immune system by inhibition of T gamma-suppressor killers and their precursors generation, of endogenic regulators suppressive activity, normalization of T-lymphocyte and natural killer activity, stimulation of B-lymphocyte recovery.
Neprina
G S
GS
Panteleeva
E S
ES
Vatin
O E
OE
Kariakin
O B
OB
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007930:Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D009367:Neoplasm Staging; D010587:Phagocytosis / Q000187:drug effects; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D007930:Leucine; C012211:ubenimex
Immunomoduliruiushchee deĭstvie bestatina pri kompleksnoĭ terapii bol'nykh rakom mochevogo puzyria.