New evidence for the antidepressant activity of MK-801, a non-competitive antagonist of NMDA receptors.
Chronic treatment with MK-801 (0.3 mg/kg ip; 5 weeks) reverses the deficit in rewarded behavior (anhedonia) measured as a decrease in the consumption of a palatable sucrose solution in a chronic mild stress model of depression in rats. The magnitude of this effect was comparable to that observed following similar administration of imipramine (10 mg/kg ip; 5 weeks), used as a standard antidepressant drug.
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
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D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012201:Reward; D013315:Stress, Psychological / Q000523:psychology
D000928:Antidepressive Agents; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D007099:Imipramine