[Effects of Celosia argentea and Cucurbita moschata extracts on anti-DNP IgE antibody production in mice].
We have already reported that the Perilla frutescens extract (PFE) suppressed anti-DNA IgE antibody production in mice. In this study, we prepared extracts of Celosia argentea L. (CAE) and Cucurbita moschata Duch (CME), which are Chinese herbal medicines like Perilla frutescens, and examined the effects on anti-DNP antibody responses in mice. To examine the effects of CAE & CME on primary antibody responses, CAE & CME were intraperitoneally injected the day before primary immunization of DNP-ovalbumin. Anti-DNP antibody production was markedly suppressed. Then, we examined the effects on secondary antibody responses. CEA & CME were injected only the day before secondary immunization. Anti-DNP IgE production was markedly suppressed, but IgG responses were not affected. It was also found that mitogenic activity occurred in CAE & CME dose dependently in vitro. These effects of CAE & CME were superior to that of PFE. These results suggest that CAE & CME may be more useful than PFE for the suppression of IgE antibody in certain allergic disorders.
Health Science Laboratories, Yamanouchi Pharmaceutical Co. Ltd.
K
K
Imaoka
H
H
Ushijima
S
S
Inouye
T
T
Takahashi
Y
Y
Kojima
D000818:Animals; D004136:Dinitrobenzenes / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C
D004136:Dinitrobenzenes; D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D007073:Immunoglobulin E