The influence of long-term administration of Tołpa Peat Preparation on immune reactivity in mice. I. Morphological changes in the thymus.
In experiment I BALB/c 200 mice were given in drinking water the TPP (Tołpa Peat Preparation) in daily doses of 1, 10 and 50 mg/kg over the period of 3, 5, 7, 9 and 12 weeks. In experiment II before the administration of TPP (as in experiment I) mice were immunized with a single dose i.p. administration of 0.2 cm3 of a 10% suspension of sheep erythrocytes (SRBC), i.e. 4 x 10(8) cells. Histopathological and ultrastructural studies have shown that TPP in all three doses causes morphological changes characteristic of thymus activity stimulation. However, the doses of 10 and 50 mg/kg administered longer than 7 weeks caused retrograde changes that did not occur after administration of 1 mg/kg of TPP. Morphological changes in the thymus of immunized and non-immunized mice simultaneously receiving TPP were similar.
Madej
J A
JA
Department of Pathological Anatomy and Forensic Veterinary, Agriculture University, Wrocław, Poland.
Kuryszko
J
J
Garbuliński
T
T
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology; D000596:Amino Acids / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D002241:Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006812:Humic Substances / Q000008:administration & dosage* / Q000494:pharmacology; D007114:Immunization; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D012987:Soil; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D014574:Uronic Acids / Q000008:administration & dosage* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; D012987:Soil; C084029:Tolpa; D014574:Uronic Acids