ACTH-(11-24) antagonizes ACTH-(1-24)-induced behavioral syndrome.
The possible involvement of the ACTH-(11-24) fragment on the stretchings, yawnings and penile erections induced by the intracerebroventricular injection of ACTH-(1-24) in rats, was studied. The results indicate that this C-terminal fragment is devoid of any behavioral activity, but inhibits the behavioral syndrome induced by ACTH-(1-24). This suggests that the fragment-(11-24) of the ACTH molecule may contain or represent an address sequence for brain ACTH receptors and may be involved in the termination of the behavioral response to melanocortins.
Institute of Pharmacology, University of Modena, Italy.
S
S
Genedani
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M
Bernardi
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003366:Cosyntropin / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D010410:Penile Erection / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010446:Peptide Fragments; D003366:Cosyntropin; C034016:ACTH (11-24)