Comparative clinical examination of Loderix (setastinum) and astemizole in pollenosis.
The action and side-effects of Loderix (EGIS) were examined in comparison with Hismanal (Janssen) containing the non-sedative H1-receptor antagonist astemizole, by double-blind, cross-over, self-controlled method. On the basis of the changes observed in response to the two drugs in the symptoms of rhinoconjunctivitis and asthma of 21 patients suffering from pollenosis Loderix proved to be of the same value as Hismanal considering both clinical effectivity and side-effects.
National Korányi Institute of TB and Pulmonology, Budapest.
I
I
Herjavecz
E
E
Karácsonyi
S
S
Mülbacher
K
K
Radics
R
R
Szilágyi
I
I
Gacsályi
D000328:Adult; D016589:Astemizole / Q000627:therapeutic use*; D001381:Azepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D012882:Skin Tests
D001381:Azepines; C053758:setastine; D016589:Astemizole