Antimicrobial activity of a new antipseudomonal dual-action drug, Ro 25-0534.
Ro 25-0534, a tertiary amine-linked dual action combination (DAC) of a catechol cephalosporin and ciprofloxacin, was compared with a previously described DAC (Ro 23-9424), ciprofloxacin and cefotaxime. A total of 688 recent clinical isolates were tested and an additional collection of 110 Gram-negative bacilli possessing documented resistance to broad-spectrum antimicrobials were used. Ro 25-0534 was active against all tested species of Enterobacteriaceae (MIC90 range, 0.06-2 micrograms/ml), oxacillin-susceptible staphylococci, beta-hemolytic streptococci, and penicillin-susceptible pneumococci (MIC90 range, 1-2 micrograms/ml). Haemophilus influenzae (MIC90 range, 0.25-0.5 micrograms/ml), Moraxella catarrhalis (MIC90, 0.5 microgram/ml), and most nonenteric Gram-negative bacilli (MIC90 range, 2-4 micrograms/ml) such as Pseudomonas aeruginosa, Acinetobacter spp., and Xanthomonas maltophilia. Enterococci and Bacteroides fragilis isolates were resistant to Ro 25-0534. The Ro 25-0354 potency against most susceptible strains was generally severalfold less than that of Ro 23-9424 (except for Pseudomonas-Xanthomonas) or ciprofloxacin alone.
Anti-Infectives Research Center, University of Iowa College of Medicine, Iowa City 52242.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D016576:Fleroxacin / Q000031:analogs & derivatives / Q000494:pharmacology; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; C060441:Ro-23-9424; C088259:Ro 25-0534; D002939:Ciprofloxacin; D002442:Ceftazidime; D002439:Cefotaxime; D016576:Fleroxacin