Derivatives of 2-mercaptobenzenesulphonamide. XI. Synthesis and some pharmacological properties of 2-(2-[2-(3,4,5-trimethoxybenzamido)ethylthio] benzenesulphonyl) guanidines.
Tree methods of synthesis of 2-(2-[2-(3,4,5-trimethoxybenzamido)ethylthio] benzenesulphonyl)guanidines (IVa-b, Va-XIVa, VIII-XII) are described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of compound [IVb, VIa, XIa-XIVa] and substrates [IIIc-f] are presented. Some structure-activity relationship is discussed.
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
Z
Z
Brzozowski
J
J
Sławiński
K
K
Oledzka
M
M
Kosmala
M
M
Filczewski
K
K
Lewandowski
J
J
Miłobedzka
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects*; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D051379:Mice; D051381:Rats; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D006146:Guanidines; D013449:Sulfonamides