Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5.
The distal portion of the long arm of chromosome 5 (5q) contains a large number of genes encoding membrane receptors belonging to various gene families, including G protein-coupled adrenergic receptors. Previous reports indicated that the genes for two of the adrenergic receptors, ADRB2 and ADRA1B, were within 300 kb of one another on 5q. In an effort to determine if a third adrenergic receptor assigned to 5q, ADRA1A, was physically close to the genes encoding the other adrenergic receptors, we attempted to place all three loci on a radiation hybrid map of 5q. The results conflicted with previous mapping results in two ways. First, ADRA1B is on 5q but is several million bases, rather than a few hundred thousand bases, from ADRB2. Second, ADRA1A is not on chromosome 5, but rather on chromosome 20. Thus, even though 5q contains an extraordinary number of genes encoding receptors for various hormones, growth factors, and neurotransmitters, there is no particular clustering of genes encoding adrenergic receptors in this region.
Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717.
S K
SK
Loftus
R
R
Shiang
J A
JA
Warrington
U
U
Bengtsson
J D
JD
McPherson
J J
JJ
Wasmuth
D000818:Animals; D001483:Base Sequence; D016466:CHO Cells; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D002895:Chromosomes, Human, Pair 5; D006224:Cricetinae; D017931:DNA Primers; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D005810:Multigene Family; D011941:Receptors, Adrenergic / Q000235:genetics*
D017931:DNA Primers; D011941:Receptors, Adrenergic