Pharmacokinetics of aditoprim and trimethoprim in buffalo calves.
Pharmacokinetic parameters of two antifolates, trimethoprim and aditoprim, were studied in buffalo calves. The elimination half-life of aditoprim (6.14 h) was nearly twice as long as that of trimethoprim (3.08 h) and compares well with values observed in heifers. This longer half-life of aditoprim is a result of its much larger distribution volume (four to five times larger) because the clearance of aditoprim was about twice as high as that of trimethoprim. The longer half-life of aditoprim is expected to give a longer duration of in vivo bacteriostatic activity than that of trimethoprim.
Department of Biochemistry, Aga Khan University, Karachi, Pakistan.
M P
MP
Iqbal
M K
MK
Ashfaq
S K
SK
Niazi
M
M
Mahboobali
K N
KN
Khawaja
D000818:Animals; D002417:Cattle; D005260:Female; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D014295:Trimethoprim / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
C051398:aditoprim; D014295:Trimethoprim