[Histopathologic lesions of the accessory salivary glands in Gougerot-Sjögren syndrome: re-evaluation of the diagnostic criteria of Chisholm and Mason and of Chometter et al].
In a retrospective study, we used a series of 29 patients with Sjögren's Syndrome diagnosed according to the new European criteria (Cl. Vitali, S. Bombardieri, H. M. Moutsopoulos et al.) (8). (Arthritis Rheum 1993; 36:340-7). A labial biopsy technique allowed to classify these patients into the anatomical "scores" formerly related by Chisholm and Mason and Chomette et al. Referring to these criteria, only 45% of patients presented a characteristic histopathological pattern. If another complementary criterium, i.e. ductal tropism of lymphoid infiltrates, was added, that percentage remained low (50% only). Thus, these results would suggest the following considerations: the classical histopathological criteria do not seem sufficiently specific; other histological criteria such as ductal lesions previously noted by Leroy et al. must in addition be looked for; thus it would seem to be of considerable value to use in the future complementary quantitative studies by means of morphometric methods.
Le Charpentier
Y
Y
Service Central d'Anatomie et Cytologie pathologiques, Groupe Hospitalier Pitie-Salpêtrière, Paris.
Auriol
M
M
Boutin
T H
TH
Le Naour
G
G
Charlotte
F
F
Agbo-Godeau
S
S
Szpirglas
H
H
Godeau
P
P
Guilbert
F
F
D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005089:Exocytosis; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012470:Salivary Glands, Minor / Q000473:pathology*; D012598:Sclerosis; D012859:Sjogren's Syndrome / Q000145:classification / Q000175:diagnosis* / Q000473:pathology
Lésions histopathologiques des glandes salivaires accessoires (G.S.A.) au cours du syndrome de Gougerot-Sjögren: réévaluation des critères diagnostiques de Chisholm et Mason et de Chomette et coll.