Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. A clinicopathologic case report.
The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corneal edema.
Eye Pathology Laboratory, Wilmer Ophthalmologic Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
T S
TS
Chang
D R
DR
Johns
W J
WJ
Stark
D B
DB
Drachman
W R
WR
Green
D000328:Adult; D001483:Base Sequence; D015139:Blotting, Southern; D015715:Corneal Edema / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004272:DNA, Mitochondrial / Q000032:analysis; D003886:Descemet Membrane / Q000648:ultrastructure; D017353:Gene Deletion; D006801:Humans; D007625:Kearns-Sayre Syndrome / Q000150:complications* / Q000235:genetics; D015948:Keratoplasty, Penetrating; D008297:Male; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D004272:DNA, Mitochondrial