[(123 I)-anti-NCA95 antibodies in diagnosis of bacterial wound infections after prosthetic vascular replacement. Comparison with computerized tomography].
Immunoscintigraphy (IS) with [123I]-anti-NCA95 labelled autologous granulocytes and computer-tomography (CT) examinations were performed in 21 patients with clinical suspicion of a vascular graft infection. The results of both IS and CT were compared with bacteriological and surgical findings. In this study the sensitivity was higher for IS compared with CT (92% and 67%, respectively). However, specificity was lower in IS compared with CT (89% and 100%, respectively). No false positive results have been found in CT. False positive results were observed in IS within 30 days after vascular surgery and may be due to a unspecific accumulation of granulocytes in perivascular hematomas. In later infection of a vascular graft (i.e. more than 30 days after surgery) no false positive findings were made by IS. In contrast, CT was false negative in two cases. IS with [125I]-anti-NCA95 labelled autologous granulocytes represents a useful tool for the detection of vascular graft infection, since granulocyte accumulation in infected tissue can be visualized with high sensitivity and specificity.
Strahlenklinik und Poliklinik UK Rudolf Virchow, FU Berlin.
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S
Venz
M
M
Cordes
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W
Hepp
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001807:Blood Vessel Prosthesis; D015815:Cell Adhesion Molecules; D006098:Granulocytes; D006801:Humans; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins / Q000276:immunology*; D011446:Prospective Studies; D016719:Radioimmunodetection; D013530:Surgical Wound Infection / Q000000981:diagnostic imaging* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins
[123J]-anti-NCA95 Antikörper in der Diagnostik bakterieller Wundinfektionen nach prothetischem Gefässersatz. Vergleich mit der Computertomographie.