Crosstalk between calcium- and cyclic AMP-mediated signalling systems and the short-term modulation of bile flow in normal and cholestatic rat liver.
The flow of bile is subject to short-term modulation by glucagon and calcium-mobilizing hormones. Of potential relevance is the crosstalk between the second messenger-mediated signal transducing systems of these agonists. This latter point has revealed an area of investigation that should enable further insights to be made into a physiological network that interrelates bile flow, hepatocellular calcium movements and hormone action. This information in turn may provide insights into the etiology and treatment of human and animal diseases in which cholestasis is an underlying feature.
Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra.
F L
FL
Bygrave
A
A
Karjalainen
Y
Y
Hamada
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002118:Calcium / Q000502:physiology*; D002779:Cholestasis / Q000139:chemically induced / Q000378:metabolism*; D000242:Cyclic AMP / Q000502:physiology*; D004997:Ethinyl Estradiol; D005934:Glucagon / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D014667:Vasopressins / Q000494:pharmacology
D014667:Vasopressins; D004997:Ethinyl Estradiol; D005934:Glucagon; D000242:Cyclic AMP; D002118:Calcium