FL-120A-D', new products related to kinamycin from Streptomyces chattanoogensis subsp. taitungensis subsp. nov. I. Taxonomy, fermentation and biological properties.
Six new kinamycin antibiotics, designated as FL-120A-D' (1-6) were isolated from the culture filtrate of Streptomyces sp. strain IY2-13. Based on its cultural, physiological, morphological and chemical characteristics, this strain was identified as a new subspecies of Streptomyces chattanoogensis and named S. chattanoogensis subsp. taitungensis. These kinamycins have demonstrated a potent activity against Gram-positive aerobic and anaerobic bacteria.
Division of Microbiology, National Defense Medical Center, Taipei, Taiwan, R.O.C.
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002227:Carbazoles / Q000097:blood / Q000737:chemistry / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004852:Epoxy Compounds / Q000097:blood / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D007928:Lethal Dose 50; D051379:Mice; D008854:Microscopy, Electron; D015394:Molecular Structure; D012988:Soil Microbiology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D000095602:Angucyclines and Angucyclinones
D000900:Anti-Bacterial Agents; D002227:Carbazoles; D004852:Epoxy Compounds; C088443:FL 120B'; C088444:FL 120C; C088445:FL 120C'; C088442:kinamycin D; D000095602:Angucyclines and Angucyclinones