A novel, conserved gene of the rat that is developmentally regulated in the testis.
From a rat testis library three overlapping cDNA clones were isolated that represent a novel single-copy gene, designated Tegt. Two transcripts of 2.8 and 1.0 kb were found in each organ tested. The shorter transcript was highly abundant in adult testis. A similar expression pattern was found in the mouse. Analysis of rat RNA from different stages of spermatogenesis indicated that accumulation of the short transcript occurred mainly postmeiotically. The rat Tegt gene maps to Chromosome (Chr) 7, and its mouse homolog to Chr 15.
Walter
L
L
Division of Immunogenetics, University of Göttingen, Germany.
Dirks
B
B
Rothermel
E
E
Heyens
M
M
Szpirer
C
C
Levan
G
G
Günther
E
E
D000375:Aging / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001483:Base Sequence; D015139:Blotting, Southern; D002417:Cattle; D002645:Chickens; D002874:Chromosome Mapping; D017124:Conserved Sequence; D005260:Female; D005786:Gene Expression Regulation; D015723:Gene Library; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D051379:Mice / Q000235:genetics; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011506:Proteins / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013737:Testis / Q000254:growth & development / Q000378:metabolism*; D014158:Transcription, Genetic; D014337:Trout; D014982:Xenopus laevis
D051017:Apoptosis Regulatory Proteins; D008565:Membrane Proteins; D011506:Proteins; C088008:Tmbim6 protein, rat