B-lineage differentiation in normal and transformed cells and the microenvironment that supports it.
B-cell differentiation is a complex process mediated through interactions with the microenvironment of the bone marrow and fetal liver. These interactions alter patterns of gene expression and allow precursors to develop into Ig+ B cells. Recent work has shown that some of these events can be triggered in B-cell precursors transformed by Abelson virus. Other advances have refined our understanding of the role of cytokines, hormones and stromal cells in the differentiation process.
Tufts University School of Medicine, Boston.
N
N
Rosenberg
P W
PW
Kincade
D000011:Abelson murine leukemia virus; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002461:Cell Line, Transformed / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D015322:Gene Rearrangement, B-Lymphocyte; D006728:Hormones / Q000502:physiology; D007107:Immune System / Q000254:growth & development; D015851:Interleukin-7 / Q000502:physiology
D015815:Cell Adhesion Molecules; D016207:Cytokines; D006728:Hormones; D015851:Interleukin-7