[The participation of cardioactive peptides in the processes of habituation and sensitization of the synaptic input to the command neurons in snail defensive behavior].
Small cardioactive peptide (SCPb) application in a concentration of 5 x 10(-8) M in the saline results in a significant increase of the amplitude of the summary excitatory postsynaptic potential elicited by the intestinal nerve stimulation in the command neurons (CN) for withdrawal reactions. Serotonin (5-HT) exerts comparable effects in a concentration of 10(-6) M. FMRFamide application (10(-6) M) significantly decreases the amplitude of the synaptic response to a single stimulus. Habituation rate of synaptic responses to the rhythmic (0.1 cps) stimulation in CN is significantly increased by serotonin application. SCPb acts in a similar fashion but in a lower concentration. FMRFamide application in a concentration of 10(-6) M affects in the opposite way the habituation rate of synaptic responses to rhythmic stimulation and in some cases evokes sensitization of responses.
Bravarenko
N I
NI
D000818:Animals; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D019835:FMRFamide; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007447:Invertebrate Hormones / Q000494:pharmacology / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D007447:Invertebrate Hormones; D009479:Neuropeptides; D012701:Serotonin; D019835:FMRFamide; C041307:small cardioactive peptide B
Uchastie kardioaktivnykh peptidov v protsessakh privykaniia i sensitizatsii sinapticheskogo vkhoda komandnykh neĭronov oboronitel'nogo povedeniia ulitki.