Successful long-term course after heart transplantation for anthracycline cardiomyopathy in a young boy despite neurological complications.
A now 14-year-old boy underwent orthotopic heart transplantation at the age of 13 for anthracycline cardiomyopathy which was a sequela of polychemotherapy for embryonal teratocarcinoma at the age of 1 year. Despite perioperative cerebellar infarction with signs of herniation which required emergency right cerebellar hemispherectomy the long-term course after 18 months turned out to be favorable with complete medical and psychosocial rehabilitation.
Department of Thoracic, Cardiac and Vascular Surgery, Westphalian Wilhelms University, Münster, Germany.
M C
MC
Deng
D
D
Kececioglu
M
M
Weyand
D
D
Moskopp
A
A
Fahrenkamp
M
M
Wendt
H H
HH
Scheld
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D002531:Cerebellum / Q000098:blood supply* / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004677:Encephalocele / Q000473:pathology / Q000601:surgery*; D004699:Endocardium / Q000473:pathology; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D008933:Mitochondrial Swelling / Q000187:drug effects; D009206:Myocardium / Q000473:pathology; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D018243:Teratocarcinoma / Q000188:drug therapy* / Q000601:surgery; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000601:surgery
D004317:Doxorubicin