[Familial aggregation and HLA typing of pedigrees in insulin-dependent diabetes mellitus].
In 280 patients with IDDM, the positive family history of diabetes was 26.8% of IDDM probands. The prevalence of diabetes in relatives was 68% in first degree relatives, 28% in second degree relatives, and 4% in third degree relatives. HLA typing of 87 members in 13 pedigrees with IDDM was performed. These data support the hypothesis that IDDM is a multigenic hereditary disorder.
Peking Union Medical College Hospital, Beijing.
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D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000145:classification*; D006801:Humans; D008297:Male; D010375:Pedigree
D006680:HLA Antigens