Association of serum copper and zinc with serum electrolytes and with selected risk factors for cardiovascular disease in men aged 55-75 years. NFR Study Group.
Serum Cu (S-Cu) and Zn (S-Zn) levels were determined in 1468 out of 1856 male subjects aged 55-75 years living in the Rome area who participated, between 1989 and 1990, in the second examination in an epidemiological (New Risk Factors) survey. Mean S-Cu and S-Zn concentrations were 15.98 mumol/l (mean +/- 2SD: 10.38-21.58 +/- mumol/l) and 13.69 mumol/l (mean +/- 2SD: 8.94-18.44 mumol/l), respectively. S-Cu levels were directly related to serum calcium levels (S-Ca), serum magnesium levels (S-Mg), daily cigarette consumption, total cholesterol and age (years). S-Zn levels were directly related to S-Ca, S-Mg and cholesterol and inversely related to age. A weak inverse linear relationship existed between S-Zn and S-Cu. After adjustment for body mass index (BMI), smoking habit, alcohol consumption and blood biochemistry in a multiple linear regression model, the relationship of S-Cu (direct) and S-Zn (inverse) to age remained statistically significant.
Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, Rome, Italy.
A
A
Menditto
G
G
Morisi
A
A
Alimonti
S
S
Caroli
F
F
Petrucci
A
A
Spagnolo
A
A
Menotti
D000368:Aged; D000375:Aging / Q000097:blood; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000097:blood*; D004573:Electrolytes / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D015032:Zinc / Q000097:blood*
D004573:Electrolytes; D003300:Copper; D002784:Cholesterol; D008274:Magnesium; D015032:Zinc; D002118:Calcium