Increased urinary endothelin-1-like immunoreactivity excretion in NIDDM patients with albuminuria.
OBJECTIVE
To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria.


METHODS
Urinary ET-1-LI substance was determined by radioimmunoassay in 45 normoalbuminuric and 28 albuminuric NIDDM patients.


RESULTS
The mean amounts of 24-h ET-1-LI excretion in NIDDM patients with normoalbuminuria and albuminuria were 154.9 +/- 13.5 and 174.4 +/- 12.9 ng/day, respectively. The latter was significantly higher than that of the 40 normal control subjects (111.8 +/- 7.9 ng/day, P < 0.01).


CONCLUSIONS
The increase in urinary ET-1-LI substance excretion in patients with albuminuria suggests that ET-1 may be a pathogenetic factor in diabetic nephropathy.
Lee
Y J
YJ
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Shin
S J
SJ
Tsai
J H
JH
D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000652:urine; D016232:Endothelins / Q000652:urine*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay / Q000379:methods; D012016:Reference Values
D015415:Biomarkers; D003404:Creatinine; D016232:Endothelins; D006442:Glycated Hemoglobin