How many embryos should be transferred in in vitro fertilization? A prospective randomized study.
OBJECTIVE
To maintain the rate of pregnancy, while suppressing high rank multiple pregnancies by limiting the number of fresh embryos transferred after IVF, in a population selected for potential success.


METHODS
A prospective, randomized study.


METHODS
Département de Gynécologie Obstétrique, Centre Hospitalo Universitaire, Paris VI, France.


METHODS
There were two groups of 28 couples. Women were < or = 35 years of age, with > or = 70% cleavage rate and at least four morphologically regular embryos.


METHODS
On the day of ET, either four fresh embryos were transferred (group 1) or two fresh embryos were transferred and two were frozen for later transfer (group 2).


RESULTS
Pregnancy rate and multiple pregnancy.


RESULTS
The pregnancy rate was the same in the two groups with one-third of the high rank pregnancies in group 1 and no pregnancies in group 2.


CONCLUSIONS
Only two fresh embryos need to be transferred in this selected population.
Département de Gynécologie Obstétrique, Centre Hospitalo Universitaire Pitié Salpétrière, Paris, France.
D
D
Vauthier-Brouzes
G
G
Lefebvre
S
S
Lesourd
J
J
Gonzales
Y
Y
Darbois
D000328:Adult; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011446:Prospective Studies