The effect of delta sleep-inducing peptide (DSIP) on the changes of body (core) temperature induced by serotonergic agonists in rats.
Hyperthermia induced by high doses of 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT) was diminished and hypothermia induced by low doses of 5-MeODMT was enhanced by pretreatment with delta sleep-inducing peptide (DSIP). Delta sleep-inducing peptide had an enhancing effect of hypothermia induced by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). This action of DSIP was completely inhibited by ICV injection of anti-DSIP. Pindolol prevented the enhancing action of DSIP on both 8-OH-DPAT- and apomorphine-induced hypothermia. It is suggested that the thermoregulatory action of DSIP is primarily exerted by a 5-HT1A mechanism in the rat.
National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan.
K
K
Tsunashima
N
N
Kato
A
A
Masui
K
K
Takahashi
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010869:Pindolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists; D012701:Serotonin; D003701:Delta Sleep-Inducing Peptide; D010869:Pindolol; D006220:Haloperidol; D004298:Dopamine