Follicular toxic pustuloderma associated with allopurinol.
Allopurinol is widely prescribed for primary and secondary hyperuricaemia, and cutaneous adverse reactions are seen in 0.8-2.1% of recipients. The majority of these are mild and include pruritus, diffuse or maculo-papular erythema, urticaria and ichthyosis. More severe reactions are well recognized and include exfoliative dermatitis, toxic epidermal necrolysis and a generalized hypersensitivity syndrome. The latter typically comprises fever, rash, hepatic and renal dysfunction and eosinophil leucocytosis. The occurrence of toxic pustuloderma due to allopurinol, confirmed by re-challenge, is reported.
Fitzgerald
D A
DA
Department of Dermatology, North Staffordshire Hospital Centre, Hartshill, Stoke-on-Trent, UK.
Heagerty
A H
AH
Stephens
M
M
Smith
A G
AG
D000493:Allopurinol / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
D000493:Allopurinol