Formaldehyde-free collagen glue in experimental lung gluing.
Because of the well-known limitations of the adhesive strength of fibrin glue, it is imperative to develop a stronger glue with acceptable biocompatibility. This was accomplished by removing the formaldehyde component from gelatin-resorcinol-formaldehyde glue and replacing it by two less toxic aldehydes--pentanedial and ethanedial. To evaluate the adhesive strength of this new glue, GR-DIAL, lung incisions in rabbit hybrids were glued together. Each group (n = 5) was examined histologically after 2 days and 1, 2, and 4 weeks. The glue disintegrated gradually with good bioresorption when the incision was closed with a thin layer of glue. The healing process was favorable, indicating good biocompatibility. Therefore, GR-DIAL glue is capable of enhancing the use of surgical glues in the field of thoracic surgery by enabling surgeons to close larger parenchymal lesions than with fibrin glue.
Ennker
I C
IC
Department of Cardiothoracic and Vascular Surgery, German Heart Institute, Berlin.
Ennker
J
J
Schoon
D
D
Schoon
H A
HA
Rimpler
M
M
Hetzer
R
R
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use*; D001673:Biodegradation, Environmental; D003094:Collagen / Q000737:chemistry* / Q000627:therapeutic use*; D004338:Drug Combinations; D005549:Foreign-Body Reaction / Q000473:pathology; D005557:Formaldehyde; D005780:Gelatin / Q000737:chemistry* / Q000627:therapeutic use*; D005976:Glutaral / Q000737:chemistry* / Q000627:therapeutic use*; D006037:Glyoxal / Q000737:chemistry* / Q000627:therapeutic use*; D006097:Granulation Tissue / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D008168:Lung / Q000473:pathology / Q000601:surgery*; D016676:Macrophages, Alveolar / Q000473:pathology; D010998:Pleurisy / Q000473:pathology; D011013:Pneumonectomy; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology; D011817:Rabbits; D012038:Regeneration; D012118:Resorcinols / Q000737:chemistry* / Q000627:therapeutic use*; D013908:Thoracotomy; D014014:Tissue Adhesives / Q000737:chemistry* / Q000627:therapeutic use*
D001672:Biocompatible Materials; D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C087754:gelatin-resorcinol-pentanedial-ethanedial adhesive; D005557:Formaldehyde; D006037:Glyoxal; D005780:Gelatin; D003094:Collagen; D005976:Glutaral; C031389:resorcinol