Isotopic estimation of the hepatic glucose balance in vivo.
Conventional determination of "hepatic glucose production" in the refed state is based on the 30-year-old Steele model, which omits glucose<-->glucose-6P cycling. Using the more complete model, conventional hepatic glucose production is shown to be a complex ratio of fluxes, and not a simple physiological flux. Our new model allows some prospective isotopic approaches to the estimation of glucose-6-phosphatase and glucokinase fluxes, and thus real net hepatic glucose production or uptake.
Whittier Institute, La Jolla, CA 92037.
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Rognstad
D000818:Animals; D004285:Dogs; D004435:Eating / Q000502:physiology; D005215:Fasting / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism*; D006801:Humans; D007554:Isotopes; D008099:Liver / Q000378:metabolism*; D008954:Models, Biological; D051381:Rats
D005958:Glucosephosphates; D007554:Isotopes; D019298:Glucose-6-Phosphate; D005947:Glucose