Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture.
Six neoplastically-derived cell lines and three cell lines derived from normal tissues were compared for their sensitivity to isoprenoid trans-trans farnesol. Assays of cell numbers and of protein concentrations per culture revealed greater sensitivity of neoplastic cells than of the normal cells. Similar differences were obtained from the comparison of incorporation of [methyl-3H]choline into cellular lipids, with neoplastic cells showing greater inhibition than normal cells.
Adany
I
I
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66103.
Yazlovitskaya
E M
EM
Haug
J S
JS
Voziyan
P A
PA
Melnykovych
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D005204:Farnesol / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
D005204:Farnesol