[Analgesic effect and no physical dependence of amygdalin].
Analgesic effect of amygdalin (AM) in mice was observed in hot plate and acetic acid-induced writhing tests. AM did not induce tolerance as morphine did, and did not cause morphine-characteristic tail-erecting response in mice. Mice given AM and then challenged with nalorphine showed no jumping response. AM could not substitute for morphine in morphine-addicted rats in relieving withdrawal syndrome. No antiinflammatory activity was found with AM.
School of Pharmacy, Second Military Medical University, Shanghai.
Y P
YP
Zhu
Z W
ZW
Su
C H
CH
Li
D000678:Amygdalin / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D019966:Substance-Related Disorders
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000678:Amygdalin; D009020:Morphine