Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?
Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with epsilon 4 is probably not due to linkage disequilibrium.
Department of Medicine, University of Toronto, Ontario, Canada.
T
T
Tsuda
R
R
Lopez
E A
EA
Rogaeva
M
M
Freedman
E
E
Rogaev
D
D
Drachman
D
D
Pollen
J
J
Haines
Y
Y
Liang
D R
DR
McLachlan
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007585:Jews / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D001057:Apolipoproteins E