Familial aggregation of carcinoma of the endometrium.
OBJECTIVE
Our purpose was to describe histologically verified endometrial carcinoma and other cancer types manifested through three generations in a pedigree, where these findings do not fit any classic hereditary cancer syndrome.


METHODS
Our family study protocol used detailed patient interviews whenever possible and questionnaires with permission forms that, when signed, enabled retrieval of pertinent medical-genetic and pathologic study documents.


RESULTS
Endometrial carcinoma was histologically verified in five women through three consecutive generations. The triad of obesity, hypertension, and diabetes mellitus was not observed. Primary carcinomas of both the endometrium and ovary and endometrium and lymphoma were documented in two relatives in the direct genetic lineage of the pedigree.


CONCLUSIONS
An aggregation of endometrial carcinoma in families, even when classic hereditary cancer syndrome identification is lacking, nevertheless merits surveillance and management strategies targeted to putative high-risk family members.
Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178.
H T
HT
Lynch
J
J
Lynch
T
T
Conway
P
P
Watson
R L
RL
Coleman
D016889:Endometrial Neoplasms / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D010375:Pedigree; D011159:Population Surveillance