Acute effect of nasal CPAP on periodic limb movements associated with breathing disorders during sleep.
Sleep-disordered breathing is commonly associated with periodic limb movements (PLMS). Nasal continuous positive airway pressure (nCPAP) is the most widely used treatment for sleep-disordered breathing. However, it is not clear whether nCPAP treatment of apnea also has a systematic effect on PLMS. We studied 15 patients with sleep-disordered breathing and PLMS in a split-night protocol in order to confirm the acute effects of nCPAP on PLMS. Although the PLMS index (PLMSI) did not change statistically (baseline, 38.7 +/- 20.5; CPAP, 31.3 +/- 17.0; p = ns), the PLMS-related index (PLMS-ArI) decreased significantly on nCPAP (baseline, 17.8 +/- 10.1; CPAP, 9.2 +/- 5.7; p < 0.05). Whether the reduced PLMS-ArI is sustained with chronic nCPAP is unknown and a matter of future investigation.
Department of Respiratory Medicine, University of Manitoba, Canada.
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Yamashiro
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Kryger
D000328:Adult; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D011175:Positive-Pressure Respiration / Q000379:methods*; D012120:Respiration Disorders / Q000503:physiopathology / Q000628:therapy*; D012891:Sleep Apnea Syndromes / Q000628:therapy; D012893:Sleep Wake Disorders / Q000503:physiopathology / Q000628:therapy*