Adverse reactions to dapsone in persons infected with human immunodeficiency virus.
Dapsone is used in prophylaxis for and treatment of Pneumocystis carinii pneumonia. We present a case of Stevens-Johnson syndrome that was likely induced by administration of dapsone. A review of charts at the HIV Treatment Center of Northwestern University (Chicago) revealed that 40.3% of patients treated with trimethoprim-sulfamethoxazole could not tolerate the medication, while 25.2% of those treated with dapsone were intolerant of the drug. We also found a higher rate of adverse reactions to dapsone among patients with prior intolerance to trimethoprim-sulfamethoxazole than among patients without such a history; however, the difference was not significant.
Division of Infectious Diseases, Northwestern University, Medical School, Chicago, Illinois 60611.
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D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D003622:Dapsone / Q000009:adverse effects*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003622:Dapsone