Systemic toxicity and dermal irritation of Tołpa Peat Preparation.
The systemic toxicity of the peat preparation in rats and rabbits was assessed. Dermal irritation tests were conducted on rabbits. In acute and chronic toxicity studies TPP was well tolerated in both animal species. Laboratory findings revealed no hematologic abnormalities as well as disturbances in liver and kidney function. No local irritancy of TPP was found. The results show that TPP may be considered as practically non toxic.
Department of Pharmacology, Drug Institute, Warsaw, Poland.
H
H
Czyzewska-Szafran
Z
Z
Jastrzebski
D
D
Sołtysiak-Pawluczuk
M
M
Wutkiewicz
A
A
Jedrych
M
M
Remiszewska
D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D002241:Carbohydrates / Q000633:toxicity*; D004338:Drug Combinations; D005260:Female; D006812:Humic Substances / Q000633:toxicity*; D007509:Irritants; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D012987:Soil; D014574:Uronic Acids / Q000633:toxicity*
D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; D007509:Irritants; D012987:Soil; C084029:Tolpa; D014574:Uronic Acids