GABA-B receptor-mediated spinal inhibition.
The intravenous administration to pentobarbitone-anaesthetized cats of the GABA-B antagonists CGP 46381 and CGP 35348 blocks the longer duration component of the inhibition of lumbar extensor monosynaptic reflexes by tetanic stimulation of low threshold flexor primary afferent fibres. GABA-B receptors thus appear to be associated with this inhibitory process, in addition to bicuculline-sensitive GABA-A receptors associated with shorter duration 'presynaptic' inhibition of reflexes and the depolarization of the terminals of primary afferent fibres.
Curtis
D R
DR
Division of Neuroscience, John Curtin School of Medical Research, Canberra, Australia.
Lacey
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G
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001418:Baclofen / Q000037:antagonists & inhibitors; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology*; D003864:Depression, Chemical; D018756:GABA Antagonists; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010721:Phosphinic Acids / Q000494:pharmacology*; D018079:Receptors, GABA / Q000145:classification / Q000502:physiology; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects* / Q000503:physiopathology; D013746:Tetany / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018756:GABA Antagonists; D009943:Organophosphorus Compounds; D010721:Phosphinic Acids; D018079:Receptors, GABA; C086109:3-aminopropyl-cyclohexylmethylphosphinic acid; D005680:gamma-Aminobutyric Acid; C066430:CGP 35348; D001418:Baclofen; D001640:Bicuculline