Etidocaine and extradural somatosensory evoked potentials after posterior tibial nerve stimulation.
We have examined the effects of lumbar extradural administration of 1% etidocaine 10 ml on somatosensory evoked potentials to posterior tibial nerve stimulation measured in the cervical extradural space. Eight patients, anaesthetized with propofol and nitrous oxide, were studied before hysterectomy and a control group received a similar anaesthetic and 0.9% sodium chloride solution 10 ml in the lumbar extradural space. Etidocaine decreased significantly overall amplitude of the evoked potentials and the amplitudes of all peaks, between 30 and 50 min after extradural injection. The effects of etidocaine on spinal cord conduction were greater than those found previously for lignocaine and bupivacaine, suggesting that it is the local analgesic of choice for inhibiting afferent conduction.
Department of Anaesthesia, Northwick Park Hospital, Harrow, Middlesex.
B A
BA
Loughnan
S P
SP
McHale
K R
KR
Welsh
G M
GM
Hall
D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D005041:Etidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D011930:Reaction Time; D013979:Tibial Nerve / Q000502:physiology*; D013997:Time Factors
D005041:Etidocaine