[Regressive leukoencephalopathy induced by an overdose of cyclosporine A].
We report a case of leucoencephalopathy with tremor and generalized motor seizures a few days after introduction of cyclosporin A (Cy A) in a kidney recipient. There was a relationship between acute neurological symptoms and high and sudden blood level of Cy A (1 260 ng/ml; therapeutic range: 120-275 ng/ml). White-matter hypodensities at CT scanning and severe slow-waves abnormalities at EEG were present. All neurological symptoms were reversible after Cy A level was lowered. Three months later, a blood Cy A level at 217 ng/ml due to nicardipine co-administration resulted in severe tremor and was reversed by decreasing blood Cy A level to 126 ng/ml.
Service d'Explorations Fonctionnelles Neurologiques, Centre Hospitalier Régional et Universitaire de Brest.
D
D
Mabin
I
I
Fourquet
P
P
Richard
S
S
Esnault
M S
MS
Islam
B
B
Bourbigot
D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D062787:Drug Overdose; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008875:Middle Aged; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed
D016572:Cyclosporine
Leucoencéphalopathie régressive au cours d'un surdosage en cyclosporine A.