Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma.
We describe the cytogenetic findings in five mucoepidermoid carcinomas (MEC) of the major and minor salivary glands. Three of the five tumors analyzed showed an apparently identical t(11;19)(q14-21;p12). In one case, the t(11;19) was the only common clonal abnormality, while in the other two cases the translocation was found together with +16, +20, and inv(1)(p32-33q42), t(6;15)(p12;q25), respectively. The latter case also showed an interstitial short arm deletion of the der(11) chromosome. Of the two remaining cases, one had a del(3)(p13p23) as the sole karyotypic abnormality, while the other had a hyperdiploid stemline characterized by the following numerical deviations: +2, +5, +6, +7, +8, +17, +18, and +19. These findings, together with previously published data from seven from seven MEC, indicate that at least two different, partially overlapping cytogenetic subgroups exist: 1) cases with structural rearrangements of 11q14-22; the finding of three tumors with an apparently identical t(11;19)(q14-21;p12) demonstrates that this is a non-random, and possibly primary abnormality in MEC, and 2) single or multiple trisomies, either observed as the sole anomalies or in combination with structural rearrangements.
Department of Oral Pathology, University of Göteborg, Sweden.
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A
Nordkvist
H
H
Gustafsson
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M
Juberg-Ode
G
G
Stenman
D000328:Adult; D000368:Aged; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics*; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy