Immediate hypersensitivity reaction to cyclophosphamide.
We report a case of an acute anaphylactic reaction to intravenous cyclophosphamide in a patient with systemic lupus erythematosus. Skin testing for reactivity to cyclophosphamide and one of its metabolites, 4-hydroperoxycyclophosphamide, was performed on the patient and on 6 controls. The patient exhibited positive skin test responses; all controls had negative responses. The results suggest an acute hypersensitivity reaction related to sensitivity to cyclophosphamide and to 4-hydroperoxycyclophosphamide, through a shared antigenic determinant or dual sensitization.
Knysak
D J
DJ
University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109-0380.
McLean
J A
JA
Solomon
W R
WR
Fox
D A
DA
McCune
W J
WJ
D000328:Adult; D000707:Anaphylaxis / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007275:Injections, Intravenous; D012882:Skin Tests
D003520:Cyclophosphamide