An update on Shigella vaccines.
Recent advances in the understanding of the molecular virulence mechanisms of Shigella have helped to develop a new generation of candidate Shigella vaccines. Approaches that are currently under active study include construction of hybrid Shigella-E. coli strains, performance of attenuating mutations in vitro on natural Shigella strains and acellular, lipopolysaccharide-based vaccines.
Ashkenazi
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Medical Corps, Israel Defense Forces.
Cohen
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D000818:Animals; D001428:Bacterial Vaccines; D001702:Biopharmaceutics; D004405:Dysentery, Bacillary / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D012703:Serotyping; D012760:Shigella / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014774:Virulence / Q000235:genetics
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated