Serum beta-endorphin in non-dialysed and haemodialysed patients with chronic renal failure.
Endogenous opioid peptides play an important role in the pathogenesis of uraemic syndrome. The effect of insulin-induced hypoglycaemia on serum beta-endorphin (BE) concentration was studied in 27 uraemic patients and in 14 healthy subjects. Despite elevated basal BE level, that correlated positively with serum creatinine, uraemic patients showed a normal BE secretory pattern. No differences were found between uraemic patients on conservative and those on haemodialysis treatment. The influence of haemodialysis treatment on BE secretion requires further investigations.
Trelewicz
P
P
Department and Clinic of Internal Medicine and Occupational Diseases, Zabrze, Poland.
Grzeszczak
W
W
Drabczyk
R
R
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000628:therapy; D001615:beta-Endorphin / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D001615:beta-Endorphin