Differential responses to a single antidepressant in recurrent episodes of major depression.
OBJECTIVE
The study examined whether patients who responded to an antidepressant in one episode of depression responded to the same agent in a subsequent episode. It also sought to determine whether in a subsequent episode clinicians prescribed an antidepressant that had previously been effective.


METHODS
Charts of inpatients with a diagnosis of major depression who were consecutively admitted to general hospital psychiatric wards were screened to determine whether the patients met the inclusion criteria of recurrent major depression and had responded to antidepressant therapy in a previous episode. Data were collected on type of treatment and treatment response for each episode.


RESULTS
Fifty-nine patients met the inclusion criteria. Thirty-five of the patients (59.3 percent) were prescribed the same antidepressant in both the current and previous episodes. Of these, 20 patients responded and 15 did not. Of the 24 patients who did not receive the same antidepressant, 14 were attended by the same clinician in both treatment episodes. Nineteen of the 24 patients responded to a new antidepressant, and five did not.


CONCLUSIONS
Patients with recurrent depression are often prescribed antidepressants other than those that were effective in previous treatment episodes. Use of a previously effective antidepressant may not increase the treatment response rate in a subsequent depressive episode.
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
A J
AJ
Remillard
S L
SL
Blackshaw
A
A
Dangor
D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D010359:Patient Readmission; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic