Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases.
The case histories are reported of two patients with systemic lupus erythematosus (SLE) who developed fatal neurological involvement, each presenting with cerebellar and brainstem signs. Neuro-pathological changes were confined to the cerebellum and brainstem, with clear evidence of a small vessel vasculopathy. The predominant histological abnormalities were multiple perivascular haemorrhages in one case and classical vasculitic changes in the other.
Smith
R W
RW
Department of Rheumatology, Southampton University Hospitals, Southampton General Hospital, United Kingdom.
Ellison
D W
DW
Jenkins
E A
EA
Gallagher
P J
PJ
Cawley
M I
MI
D000328:Adult; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000098:blood supply*; D002531:Cerebellum / Q000098:blood supply*; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology