Poly(vinyl alcohol) hydrogels as soft contact lens material.
A new type of soft contact lens was developed from the poly(vinyl alcohol) (PVA) hydrogel prepared by a low temperature crystallization technique using a water-dimethyl sulfoxide mixed solvent. The PVA contact lens materials had a water content of 78% and a tensile strength of 50 kg/cm2, five times as strong as that of commercial poly(2-hydroxyethyl methacrylate) soft contact lens. The amount of proteins adsorbed to the PVA soft hydrogel material was half to one thirtieth of that of conventional soft contact lenses. Histological and scanning electron microscopic observation of rabbit eyes which had worn the PVA soft contact lens for 12 weeks showed no difference in corneal epithelium and cell arrangement in the corneal epithelium from the non-wearing eyes.
Research Center for Biomedical Engineering, Faculty of Medicine, Kyoto University, Japan.
S H
SH
Hyon
W I
WI
Cha
Y
Y
Ikada
M
M
Kita
Y
Y
Ogura
Y
Y
Honda
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000166:cytology* / Q000648:ultrastructure; D004121:Dimethyl Sulfoxide; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D007074:Immunoglobulin G; D008855:Microscopy, Electron, Scanning; D009113:Muramidase; D011102:Polyhydroxyethyl Methacrylate; D011142:Polyvinyl Alcohol; D011817:Rabbits; D012710:Serum Albumin, Bovine; D012997:Solvents; D013997:Time Factors; D014867:Water
D001672:Biocompatible Materials; D007074:Immunoglobulin G; D012997:Solvents; D014867:Water; D011102:Polyhydroxyethyl Methacrylate; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol; D009113:Muramidase; D004121:Dimethyl Sulfoxide