Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation.
We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.
Department of Pediatrics and Cell Biology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
S P
SP
Ionides
M G
MG
Weiss
M
M
Angelopoulos
T F
TF
Myers
R J
RJ
Handa
D005260:Female; D005283:Fentanyl / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009020:Morphine / Q000494:pharmacology / Q000627:therapeutic use*; D009126:Muscle Relaxation / Q000187:drug effects; D010197:Pancuronium / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects; D012140:Respiratory Tract Diseases / Q000628:therapy; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin; D009020:Morphine; D010197:Pancuronium; D005283:Fentanyl