The effect of high protein and high salt intake for 4 months on calcium and hydroxyproline excretion in normal and oophorectomized rats.
The effect of feeding high protein (40%) and high salt intake (18 gm/L of sodium chloride in drinking water) for 4 months on the urinary excretion of calcium and hydroxyproline (OHP) in sham operated and oophorectomized (OX) rats was studied. OX rats had higher body weight and increased excretion of calcium and OHP. Feeding a high-salt diet caused an increase in the excretion of calcium, phosphate, and OHP. The high-protein diet had a similar effect. There was a significant interaction between the effects of salt and protein on calcium excretion. OX did not influence the effect of high salt or high protein intakes. It is concluded that high protein and/or high salt intake increases the excretion of calcium and OHP. The effect is seen even after 4 months of the diet. Oophorectomy did not cause any additional effect.
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital.
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Chan
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Swaminathan
D000704:Analysis of Variance; D000818:Animals; D002118:Calcium / Q000652:urine*; D003404:Creatinine / Q000652:urine; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006909:Hydroxyproline / Q000652:urine*; D009318:Natriuresis; D010052:Ovariectomy; D010710:Phosphates / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors; D014508:Urea / Q000652:urine
D004044:Dietary Proteins; D010710:Phosphates; D012965:Sodium Chloride; D014508:Urea; D003404:Creatinine; D006909:Hydroxyproline; D002118:Calcium