Effect of nasal anaesthesia on lacrimal function after nasal allergen challenge.
Ocular symptoms in allergic rhinoconjunctivitis arise partly from direct contact of the allergen with the conjunctiva and presumably partly from a naso-lacrimal reflex. The aim was to study the importance of this reflex in allergic rhinitis after topical anaesthesia of the nose. Ten patients with allergic rhinoconjunctivitis to birch pollen were challenged with increasing intranasal doses of allergen until allergic symptoms occurred. The same dose of allergen was used in two other provocations, when the nasal cavity was anaesthetized with topical lidocaine in a double-blind randomized cross-over manner. The effect on the eyes was evaluated by Shirmer's test, a routine method for measuring tear production. Lidocaine per se and/or allergen challenge had no significant effect on tear production. The naso-lacrimal reflex was not involved in the eye symptoms in allergic conjunctivitis.
Department of Otorhinolaryngology, Central Hospital, Skövde, Sweden.
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D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000008:administration & dosage*; D000772:Anesthesia, Local; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007765:Lacrimal Apparatus / Q000276:immunology* / Q000503:physiopathology*; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D011058:Pollen / Q000276:immunology; D012018:Reflex / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000503:physiopathology*; D013666:Tears / Q000378:metabolism
D000485:Allergens; D008012:Lidocaine