Heart rate changes following habituation testing of the motor response in normal human fetuses.
We examined the heart rate (HR) response immediately following habituation testing in 54 normal human fetuses between 34 and 40 weeks of gestation to determine if cardiac self-regulation was a function of the rate of motor habituation. All fetuses received eight trials of a 1-s vibroacoustic stimulus (VAS) with a 10-s interstimulus interval. A score of 0-10 was assigned for each trial based on subjective assessment of intensity and duration of the fetal motor response. Motor habituation was evaluated in terms of the rate of response decrement over trials. For each fetus the average post-VAS HR was calculated in 1-min blocks for the first 7 min following habituation testing. When subjects were divided into slow and fast motor habituators, we found that fetuses who were slow habituators displayed a significantly greater increase in HR above baseline at each of the first 7 min following habituation testing as compared to fetuses whose motor response habituated more rapidly, F(1,52) = 4.88, P = 0.03. However, there was no difference between slow and fast motor habituators in the rate at which the HR returned toward prestimulus levels. To further examine these results, we divided the 54 fetuses into four groups based on the medians of the slope of the post-VAS HR regression line and the variability in HR about this line. We found that fetuses whose HR decreased slowly after habituation testing displayed significantly greater variability in their cardiac response as compared to fetuses whose HR decreased more rapidly (chi 2 = 4.74, P = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
Groome
L J
LJ
Department of Obstetrics and Gynecology, University of South Alabama, Mobile 36617.
Watson
J E
JE
Dykman
R A
RA
D005260:Female; D005324:Fetal Movement / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D011247:Pregnancy; D012016:Reference Values