The mechanisms of schizophrenia.
Current investigations of the mechanisms of schizophrenia usually employ one of three possible explanatory models: a single disease entity model, a multiple disease entity model, and a dimensions of psychopathology model. None of these is at present preeminent. These models are used to explore four different types of mechanisms that may produce the symptoms of schizophrenia: neurodevelopmental, neural circuitry, genetic/molecular mechanisms, and chemical anatomy.
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1057.
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Andreasen
D001921:Brain / Q000254:growth & development; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D008959:Models, Neurological; D009434:Neural Pathways / Q000503:physiopathology; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D012565:Schizophrenic Psychology
D004298:Dopamine