[The effect of the angiotensin III (Sar1, Ile7) Ang III, on water intake of Wistar rats].
A[Sar1, Ile7] AngIII, an angiotensin III analogue apparently devoid of any affinity for vascular angiotensin II (AngII) receptors, inhibits AngII-induced drinking but neither affects cellular dehydration-induced drinking nor produces any intake of water in water replete rats, suggesting that the dipsogenic effect of AngII is not of vascular origin. Thus, [Sar1, Ile7] AngIII is an interesting tool to study the central effects of AngII.
Istituto di Farmacologia, Facoltà di Farmacia, Università di Camerino.
F
F
Venturi
C
C
Polidori
G
G
De Caro
D000804:Angiotensin II / Q000494:pharmacology*; D000805:Angiotensin III / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004326:Drinking / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000804:Angiotensin II; D000805:Angiotensin III
Effetti dell'analogo della angiotensina III, [Sar1, Ile7] AngIII, sulla assunzione di acqua nel ratto Wistar.