Synthesis, transformations and tuberculostatic activity of 1-(N-aroylthiocarbamoyl)imidiazolidine-2-thiones.
Series of 1(N-aroylthiocarbamoyl)imidiazolidine-2-thiones and 3-aroylimino-5,6-dihydro-3H-imidazo[2,1-c](1,2,4) dithiazoles were prepared for antituberculostatic screening. Dithiobiuret was transformed into N1-disubstituted thiocarbamoyl 1-N-aroylthiocarbamoyl ethylenediamines by reacting with secondary amines or hydrazine derivatives.
Department of Organic Chemistry, School of Medicine, Gdańsk, Poland.
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Saczewski
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000995:Antitubercular Agents; D007093:Imidazoles; D013859:Thiocarbamates; D013871:Thiones