Hormonal signaling and regulation of salt and water transport in the collecting duct.
The regulation of transport in the collecting duct is under multi-hormonal control. Vasopressin stimulates water and cation transport, primarily through a V2/Gs-coupled receptor that activates adenylyl cyclase, which raises cAMP. These stimulatory effects are damped by the action of several hormones, including vasopressin itself, which activate inhibitory G proteins, stimulate phospholipid breakdown, increase prostaglandin production, raise intracellular Ca2+, activate protein kinase C, stimulate tyrosine kinases, and raise cGMP. These inhibitory signals interact with the stimulatory, cAMP-coupled signaling pathway at multiple levels. The balance between these pathways controls net salt and water transport in the collecting duct.
Department of Medicine, Veterans Administration Medical Center, Nashville, Tennessee.
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MD
Breyer
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Ando
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction; D012965:Sodium Chloride / Q000378:metabolism*; D014667:Vasopressins / Q000502:physiology; D014867:Water / Q000378:metabolism*
D006728:Hormones; D014867:Water; D014667:Vasopressins; D012965:Sodium Chloride; D000242:Cyclic AMP; D011505:Protein-Tyrosine Kinases; D002118:Calcium