Renal disease and rheumatic manifestations.
The musculoskeletal effects of renal failure are seen in a variety of tissue, including bone, joints, and soft tissue. These effects include avascular necrosis, osseous abnormalities, ligamentous laxity, destructive arthropathies, and soft-tissue calcifications. With the advent of therapy (dialysis, transplantation), a new generation of disorders affecting these tissues has emerged. In particular, a high prevalence of destructive cervical spondyloarthropathy, which may be due to beta 2-microglobulin type amyloidosis, can be a particularly serious problem in long-term hemodialysis patients.
Professorial Department of Rheumatology, Royal North Shore Hospital, NSW, Sydney, Australia.
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Grennan
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Manolios
D000686:Amyloidosis / Q000209:etiology; D001168:Arthritis / Q000209:etiology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D006435:Renal Dialysis / Q000009:adverse effects; D012216:Rheumatic Diseases / Q000209:etiology* / Q000628:therapy; D001613:beta 2-Microglobulin / Q000378:metabolism
D001613:beta 2-Microglobulin