Omega-conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior.
We investigated the effects of antagonists for omega-conotoxin GVIA (omega-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of omega-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, omega-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through omega-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
K
K
Yamada
T
T
Teraoka
S
S
Morita
T
T
Hasegawa
T
T
Nabeshima
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008774:Methylphenidate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009355:Neomycin / Q000494:pharmacology; D017072:Neostriatum / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D010455:Peptides; D008774:Methylphenidate; D008694:Methamphetamine; D020866:omega-Conotoxin GVIA; D009355:Neomycin; D007608:Kainic Acid