Pigmented clear cell acanthoma.
We present five cases of macroscopically pigmented clear cell acanthomas. Masson-Fontana silver stain revealed dendritic melanocytes containing melanin granules in large numbers interspersed among the tumoral keratinocytes. The dendritic cells expressed S-100 protein. Electromicroscopy, performed on one pigmented clear cell acanthoma, showed melanosomes in large numbers in the dendrites of melanocytes; whereas only a few melanosomes were found in the adjacent keratinocytes, indicating a disturbed melanin transfer. We propose the name "pigmented clear cell acanthoma" for this variant of Degos' acanthoma.
Department of Dermatology, University of Vienna, Austria.
K
K
Langer
S
S
Wuketich
K
K
Konrad
D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D012871:Skin Diseases / Q000473:pathology*