A preliminary study on IL4 levels in extrinsic atopic asthmatic children.
Interleukin 4, (IL4) known as a lymphokine secreted by type II helper T-cells, is thought to regulate IgG and IgE secretions. Therefore, elevated IL4 levels are expected in atopic allergic disease and parasitoses. The purpose of this study was to determine IL 4 levels in allergic asthmatic children. In 50 extrinsic atopic children (19 females, 31 males, mean age 8 +/- 4), IgE and IL 4 were found to be 469 +/- 296 U/L and 0.318 +/- 0.09 ng/ml, respectively. In seven control cases, IgE and IL4 levels were 62 +/- 25 and 0.106 +/- 0.017, respectively. Comparison of the two groups disclosed statistically significant differences in IL4 and IgE levels, suggesting the ability of IL4 to augment IgE production.
Akçakaya
N
N
Department of Pediatrics, Istanbul University Cerrahpaşa Faculty of Medicine.
Sözer
V
V
Cokuğraş
H
H
Söylemez
Y
Y
Yilmaz
G
G
D000293:Adolescent; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000097:blood*; D008297:Male
D015847:Interleukin-4; D007073:Immunoglobulin E