The regulation of B- and T-lymphocyte activation by the transmembrane protein tyrosine phosphatase CD45.
The expression of transmembrane protein tyrosine phosphatase CD45 is required for antigen-induced activation of T and B lymphocytes. During the past year, advances have been made in our understanding of CD45 regulation and its role in regulating Src-family members. The importance of CD45 in thymocyte maturation has been demonstrated through the generation of CD45-knockout mice.
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110.
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D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D002462:Cell Membrane / Q000201:enzymology / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D017493:Leukocyte Common Antigens / Q000378:metabolism*; D008213:Lymphocyte Activation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*
D020794:Receptor Protein-Tyrosine Kinases; D017493:Leukocyte Common Antigens; D017027:Protein Tyrosine Phosphatases