Autoimmune liver disease in patients with primary Sjögren's syndrome.
Forty-five patients with primary Sjögren's syndrome were studied for evidence of autoimmune liver disease. Twenty-nine patients had normal liver function tests, normal IgM and a normal test for antimitochondrial antibodies and smooth muscle antibodies. Among the remaining 16 patients, abnormal liver function tests were found in 12 (27% of all patients); eight of these patients had biochemical cholestasis. Elevated plasma IgM (> 2 g/l) was observed in nine patients, three with normal liver function tests, while antimitochondrial antibodies were positive in six patients, one with normal liver function tests, and smooth muscle antibodies were found in three. Based on these findings and percutaneous liver biopsy, a diagnosis of primary biliary cirrhosis was established in four patients and autoimmune chronic active hepatitis in two. The present study showed that abnormal liver function tests in patients with primary Sjögren's syndrome are frequent and may indicate associated autoimmune liver disease. These data further emphasize the systemic nature of autoimmune disorders.
Lindgren
S
S
Gastroenterology and Hepatology Division, Department of Medicine, Malmö General Hospital, Lund University, Sweden.
Manthorpe
R
R
Eriksson
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D001706:Biopsy; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood / Q000150:complications* / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology
D000906:Antibodies; D007075:Immunoglobulin M