Vesicle fusion from yeast to man.
Membrane budding and fusion occur in all eukaryotic cells. Their underlying mechanisms have been studied in mammalian neurons and in yeast, a simple eukaryote. The differences between these two systems would suggest that fusion events in yeast and the neuron would operate by different mechanisms, but recent advances indicate that this is not true.
Ferro-Novick
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Department of Cell Biology and Pharmacology, Yale University Medical School, New Haven, Connecticut 06510.
Jahn
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D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D005089:Exocytosis; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion / Q000235:genetics; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D050683:R-SNARE Proteins; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; D013570:Synaptic Membranes / Q000378:metabolism; D033921:Vesicular Transport Proteins; D015003:Yeasts
D002352:Carrier Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050683:R-SNARE Proteins; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; D033921:Vesicular Transport Proteins; D019204:GTP-Binding Proteins