[Effects of extracts from Phyllanthus urinaria L. on HBsAg production in PLC/PRF/5 cell line].
Experiment on the effect of extracts from Phyllanthus urinaria on HBsAg production in PLC/PRF/5 human hepatoma cell line showed that the production was decreased markedly 48 hours after the treatment of cells with 2-4 mg/ml Phyllanthus urinaria, especially in combination with 10(-5) mol/L of Ara-A. The decrease of extracellular HB-sAg excretion seems to stem from the inhibition of intracellular HBsAg formation.
Ji
X H
XH
Changhai Hospital, Second Military Medical University.
Qin
Y Z
YZ
Wang
W Y
WY
Zhu
J Y
JY
Liu
X T
XT
D006528:Carcinoma, Hepatocellular / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006514:Hepatitis B Surface Antigens / Q000096:biosynthesis* / Q000187:drug effects; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000378:metabolism; D014740:Vidarabine / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens; D014740:Vidarabine