Role of motilin in the control of intestinal absorption, and gastric and biliary secretions in the rat.
The effects of motilin on proline absorption and gastric and biliary secretions were examined in the rat. Prolonged intravenous administration of motilin (50 pmol/kg/min) significantly inhibited (P < 0.05) proline transport across the jejunum and reduced basal acid secretion to 40% of control value. The same concentration of motilin induced choleresis and increased bile output by 32%. Incubation of intestinal strips with different concentrations of motilin produced a dose-dependent inhibitory pattern of proline accumulation in the intestinal cells.
Department of Physiology, American University of Beirut, Lebanon.
C F
CF
Nassar
L E
LE
Abdallah
J B
JB
Atallah
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D066298:In Vitro Techniques; D007262:Infusions, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000502:physiology; D008297:Male; D009037:Motilin / Q000008:administration & dosage / Q000494:pharmacology*; D011392:Proline / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D009037:Motilin; D011392:Proline