Immunomodulating effects of heparin on human B cell proliferation.
Recent data indicate that heparin may act as an immunomodulator. In this paper we have analyzed the effects of this agent on human B cell proliferation in vitro induced by S. aureus Cowan. The action of heparin is complex, but there was a trend for inhibition of B cell responses obtained from defibrinated but not heparinized blood samples. This suggests that heparin interacts with platelet products (growth factors, cytokines) and the results of such interactions determine the final effect.
Department of Laboratory Diagnostic and Clinical Immunology, Medical Academy, Warsaw, Poland.
M
M
Wasik
B
B
Stepień-Sopniewska
A
A
Górski
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D006493:Heparin