HLA-DPB1 alleles in patients with rheumatoid arthritis.
The distribution of HLA-DPB1 alleles was studied in 94 adult Caucasian RA patients (65 = seropositive, 29 = seronegative) and 40 normal controls. The DPB1 alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of the DPB1*0402 allele was higher in seropositive RA patients and DPB1*0201 was higher in seronegative RA patients. These differences were not significant, however. It is likely that DPB1 alleles do not play an important role in susceptibility to RA.
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
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DP
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Sastry
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Buchanan
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology*; D006682:HLA-DP Antigens / Q000032:analysis* / Q000235:genetics*; D059868:HLA-DP beta-Chains; D015798:HLA-DR1 Antigen / Q000032:analysis; D015804:HLA-DR4 Antigen / Q000032:analysis; D006801:Humans; D012016:Reference Values
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen