Synthesis of 4-alkylpyrazoles as inhibitors of liver alcohol dehydrogenase.
Theoretical studies by shape analysis of the molecular electrostatic potential on the van der Waals surfaces of a set of 4-alkylpyrazoles predicted 4-isopentyl derivative as a good inhibitor of liver alcohol dehydrogenase. Thus, the new 4-isopentyl and the already known 4-octylpyrazole have been prepared by a novel route. The isopentyl derivative has been tested as inhibitor of horse liver alcohol dehydrogenase giving the result predicted by the theoretical studies.
Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Brazil.
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A
Echevarría
M
M
Martín
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C
Pérez
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I
Rozas
D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D000818:Animals; D006736:Horses; D008099:Liver / Q000201:enzymology*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D011720:Pyrazoles; D000426:Alcohol Dehydrogenase