Cell proliferation and nasal carcinogenesis.
The nasal passages of rodents provide valuable opportunities for research on relationships between cell proliferation and cancer. The nose, which has multiple functions, possesses a diverse range of tissue types, each with its own morphologic, physiologic, and metabolic characteristics and site-specific cell turnover rates. Moreover, for inhaled materials deposited in the nose, complex regional uptake or deposition patterns can result in site-specific responses, including cancer. Presented here are important criteria necessary for undertaking cell proliferation studies in the nasal passages. The current literature concerning nasal toxicity and the toxicant-induced proliferative response are also reviewed. Rodent nasal epithelium provides a fruitful area for research on the role of cell proliferation in carcinogenesis.
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
T M
TM
Monticello
E A
EA
Gross
K T
KT
Morgan
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005557:Formaldehyde / Q000633:toxicity; D006801:Humans; D007700:Kinetics; D009296:Nasal Cavity / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity; D009669:Nose Neoplasms / Q000209:etiology* / Q000473:pathology*; D051381:Rats
D002273:Carcinogens; D009602:Nitrosamines; D005557:Formaldehyde; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D004247:DNA