Structural studies of new macrolide antibiotics, shurimycins A and B.
The structures of new antibiotics, shurimycins A and B produced by Streptomyces hygroscopicus A1491, were elucidated from the physico-chemical properties, 2D NMR techniques and chemical degradation experiments to be 36-membered macrolides related to azalomycins, scopafungin and guanidylfungins. Shurimycins were active against fungi and Gram-positive bacteria.
Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan.
S
S
Kumazawa
Y
Y
Asami
K
K
Awane
H
H
Ohtani
C
C
Fukuchi
T
T
Mikawa
T
T
Hayase
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006868:Hydrolysis; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides; C088503:shurimycin B; C088502:shurimycin A