Transforming growth factor receptor gene TGFBR2 maps to human chromosome band 3p22.
In this study, we map the chromosomal position of the gene that encodes the type II receptor of TGF-beta (HGM symbol TGFBR2), a multifunctional regulator of cell proliferation and differentiation. Using a full-length cDNA and a genomic probe in Southern blot analysis of a human x rodent somatic cell hybrid panel and by direct fluorescence in situ hybridization to normal metaphase chromosomes, we show that the TGFBR2 gene maps to 3p22.
Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
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S
Mathew
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VV
Murty
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Cheifetz
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George
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Massagué
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Chaganti
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure; D004247:DNA / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D006168:Guinea Pigs; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure; D017404:In Situ Hybridization, Fluorescence; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*
D018076:DNA, Complementary; D018125:Receptors, Transforming Growth Factor beta; D004247:DNA