Sulfation of endogenous compounds and xenobiotics--interactions and function in health and disease.
Sulfation is a major detoxication mechanism for endogenous compounds and xenobiotics performed by a family of sulfotransferase isoenzymes. Understanding the normal cellular functions of these different sulfotransferases and the way in which endogenous and exogenous factors are able to influence their activity and expression will provide us with the information necessary to develop novel therapeutic strategies for conditions where sulfation may be implicated. This concept is discussed and is illustrated by examples including adverse drug reactions, fetal development and cancer.
Coughtrie
M W
MW
Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK.
Bamforth
K J
KJ
Sharp
S
S
Jones
A L
AL
Borthwick
E B
EB
Barker
E V
EV
Roberts
R C
RC
Hume
R
R
Burchell
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D015238:Sulfotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014018:Tissue Distribution; D015262:Xenobiotics / Q000378:metabolism* / Q000494:pharmacology
D015262:Xenobiotics; D015238:Sulfotransferases