Evaluation of a DNA probe assay (Gen-Probe PACE 2) as the test of cure for Neisseria gonorrhoeae genital infections.
A DNA probe (Gen-Probe PACE 2) detects portions of viable and nonviable organisms, and test results could remain positive after effective treatment of genital Neisseria gonorrhoeae infection. Twenty patients underwent test-of-cure studies 6 to 11 days after standard treatment for gonorrhea; in each case the DNA probe finding was negative. The Gen-Probe PACE 2 probe is reliable for test-of-cure study as early as 6 days after treatment.
Adolescent Medicine Service, Fitzsimons Army Medical Center, Aurora, Colorado.
J W
JW
Hanks
C T
CT
Scott
C E
CE
Butler
D W
DW
Wells
D000293:Adolescent; D000328:Adult; D001431:Bacteriological Techniques; D002443:Ceftriaxone / Q000627:therapeutic use; D015342:DNA Probes; D004269:DNA, Bacterial / Q000032:analysis; D005069:Evaluation Studies as Topic; D005260:Female; D006069:Gonorrhea / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
D015342:DNA Probes; D004269:DNA, Bacterial; D002443:Ceftriaxone