Position-effect variegation and the new biology of heterochromatin.
The phenomenon of position-effect variegation has long been used as evidence for the importance of chromosome position to gene expression in eukaryotes. Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems.
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037-1099.
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D000818:Animals; D002503:Centromere; D002843:Chromatin / Q000502:physiology; D004247:DNA; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation; D006570:Heterochromatin; D006801:Humans; D016615:Telomere
D002843:Chromatin; D006570:Heterochromatin; D004247:DNA