Non-awaking basal forebrain stimulation enhances auditory cortex responsiveness during slow-wave sleep.
Unilateral basal forebrain (BF) stimulations were delivered during slow-wave sleep (SWS) while multi-unit recordings were performed bilaterally in the auditory cortex. Ten tone presentations were followed by 10 pairing trials between BF stimulation and tone. Non-awaking BF stimulations facilitated the tone-evoked responses ipsilaterally only. Atropine blocked the facilitation of the ipsilateral evoked responses observed after pairing in wakefulness. Thus, non-awaking cholinergic input can enhance cortical responsiveness during SWS.
Laboratoire de Neurobiologie de l'Apprentissage et de la Mémoire, CNRS URA 1491, Université Paris-Sud, 91405 Orsay, France.
J M
JM
Edeline
C
C
Maho
B
B
Hars
E
E
Hennevin
D000161:Acoustic Stimulation; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001303:Auditory Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D016548:Prosencephalon / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology
D001285:Atropine