Technetium-99m labelling of bis-oxime ligands.
The synthesis and labelling of a new bis-amide-oxime ligand E,E-2,9-bis(hydroxyimino)-4,7-diaza 5,6-dioxodecane (AdO) with 99mTc has been achieved. Protein binding, partition coefficient and tissue distribution of this complex and two related bis-amine-oxime ligands is reported. The biodistribution of the complexes are disappointing with only limited brain and myocardial uptake. Structures for the complex are postulated.
Department of Chemistry, University of Cape Town, South Africa.
G E
GE
Jackson
M J
MJ
Byrne
H
H
Fakier
R
R
Hunter
M
M
Woudenberg
D000818:Animals; D004590:Electrophoresis, Paper; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010091:Oximes / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013667:Technetium / Q000737:chemistry*; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D010091:Oximes; D012710:Serum Albumin, Bovine; D013667:Technetium