[A case of malignant pheochromocytoma treated with 131I-metaiodobenzylguanidine and CVD regimen].
A 44-year-old male had multiple metastasis to the lung, liver, kidney and paraaortic lymph node from primary adrenal malignant pheochromocytoma. Radiation therapy with 131I-metaiodobenzylguanidine (131I-MIBG), was first performed, which was followed by chemotherapy with cyclophosphamide, vincristine and dacarbazine (CVD). A total amount of 4810 MBq of 131I-MIBG was administered then 7 cycles of CVD regimen were added. He was survived for sixteen months with tumor response in primary tumor, paraaortic lymph node and liver metastasis tumors, in addition to hormonal response. It was considered that the survival was prolonged in spite of advanced case with inoperative primary tumor.
Ukimura
O
O
Department of Urology, Kyoto Prefectural University of Medicine.
Kojima
M
M
Hosoi
S
S
Itoh
H
H
Watanabe
H
H
Minamikawa
T
T
D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D008297:Male; D010673:Pheochromocytoma / Q000188:drug therapy / Q000532:radiotherapy*; D014750:Vincristine / Q000008:administration & dosage
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D014750:Vincristine; D003606:Dacarbazine; D003520:Cyclophosphamide