Predicting recurrence of intracranial meningiomas. A multivariate clinicopathologic model--interim report of the New York University Medical Center Meningioma Project.
A series of 105 primary intracranial meningiomas, a subset of a larger project on over 800 such tumors, was assessed for clinical and histopathologic factors that might be predictive of recurrence. Predicting recurrence of meningiomas after a surgical resection and the criteria for and clinical importance of a diagnosis of "malignant" meningiomas are controversial issues. Using a multivariate logistic regression analysis, the data from these 105 patients suggest that the single most powerful predictor of recurrence within 5 years after tumor resection is the mitotic index of the tumor. The other powerful factor for predicting recurrence was the extent of resection. Other factors traditionally associated with recurrence or a diagnosis of malignancy were not significant factors for predicting recurrence according to this study.
Miller
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DC
New York University School of Medicine and Medical Center, New York.
D001921:Brain / Q000473:pathology / Q000601:surgery; D002455:Cell Division / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008578:Meninges / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery