Cytokine changes in the postoperative period.
The trauma of elective surgery leads to the release of cytokines, many of which act primarily at local level having been released from tissue macrophages, circulating monocytes or other activated tissues. There is also a reproducible response in plasma IL-6, the magnitude of which relates to the magnitude of operative trauma. It seems likely that cytokines have an important role in mediating the anorexia associated with the postoperative period, and this may be associated with increased release of CRF from the hypothalamus. Further studies on the interrelationship between cytokine and neuroendocrine systems will lead to a greater understanding of the control of food intake following injury, and will permit the development of new strategies to improve the effectiveness of nutrition at this time.
Shenkin
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Department of Clinical Chemistry, University of Liverpool.
D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D004435:Eating; D006801:Humans; D007700:Kinetics; D009752:Nutritional Status; D011184:Postoperative Period; D013514:Surgical Procedures, Operative
D016207:Cytokines