Peripheral neuroectodermal tumor of the chest (Askin tumor) as secondary neoplasm after Hodgkin's disease: a case report.
The authors present the case of a 20-year-old woman who developed a peripheral neuroectodermal neoplasm of the thoracopulmonary region (Askin tumor) 7 years after achieving complete remission of stage-IV Hodgkin's disease. The previous treatment had consisted of eight courses of alternating MOPP/ABVD combined with involved-field 20-Gy radiotherapy. The second neoplasm appeared in a nonirradiated area of the chest wall, with erosion of the ribs as shown by sonography and computed tomography. The histological pattern was in accordance with a generic diagnosis of a malignant small cell tumor; the immunostaining positivity of the neoplastic cells for the neuron-specific enolase allowed us to make the diagnosis of a tumor with a neuroectodermal origin. Partial resection of the neoplasm and four courses of chemotherapy including adriamycin, cisplatin, and ifosfamide induced a complete remission, confirmed by surgical restaging. She is alive and well 10 months after the completion of therapy. The clinical, radiological, and microscopic features of this tumor occurring as a secondary neoplasm after Hodgkin's disease are described.
Anselmo
A P
AP
Department of Human Biopathology, University La Sapienza, Rome, Italy.
Cartoni
C
C
Pacchiarotti
A
A
Pescarmona
E
E
Cafolla
A
A
Rendina
E
E
Mandelli
F
F
D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016609:Neoplasms, Second Primary; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology*; D013899:Thoracic Neoplasms / Q000473:pathology*