[The use of donor blood plasma with a high titer of natural antiendotoxin antibodies, irradiated by ultraviolet light, in the combined detoxification therapy of peritonitis].
The ultraviolet (UV) irradiation of donor blood plasma with an elevated level of natural antibodies to Re-glycolipid with doses ranging from 100 to 200 J/m2 has been found to lead to a statistically significant rise in its protective activity. The use of such plasma in clinical practice has made it possible to decrease the frequency of lethal outcomes from 24.3% to 16.5% (p < 0.01), the occurrence of secondary infectious complications from 62% to 44.4% (p < 0.01) and the duration of patients' stay in a hospital by 6-8 days. These data make it possible to regard the use of UV-irradiated plasma with an elevated level of Re-antibodies as an effective method of the immunotherapy of septic complications caused by gram-negative bacteria.
Apollonin
A V
AV
Rudik
A A
AA
Kropacheva
E I
EI
Likhoded
V G
VG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000528:radiation effects* / Q000627:therapeutic use*; D001782:Blood Donors; D003131:Combined Modality Therapy; D004731:Endotoxins / Q000276:immunology*; D005260:Female; D006017:Glycolipids / Q000276:immunology; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000276:immunology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications / Q000276:immunology / Q000628:therapy*; D010949:Plasma / Q000276:immunology* / Q000528:radiation effects*; D016060:Sorption Detoxification / Q000379:methods*; D014467:Ultraviolet Therapy
D000907:Antibodies, Bacterial; D004731:Endotoxins; D006017:Glycolipids; C055264:Re-glycolipid
Primenenie plazmy krovi donorov s vysokim titrom estestvennykh antiéndotoksinovykh antitel, obluchennoĭ ul'trafioletovym svetom, v kompleksnoĭ detoksikatsionnoĭ terapii peritonitov.