Cell cycle controls: potential targets for chemical carcinogens?
The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be directly linked to genomic stability. Loss of the check-points involved in cell cycle control may result in unrepaired DNA damage during DNA synthesis or mitosis leading to genetic mutations and contributing to carcinogenesis.
Afshari
C A
CA
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Barrett
J C
JC
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced / Q000473:pathology; D011506:Proteins / Q000502:physiology
D002273:Carcinogens; D011506:Proteins; D004247:DNA