Characteristic karyotypic features in lacrimal and salivary gland carcinomas.
Short-term cultures from 12 non-squamous cell carcinomas (NSCCs) of the head and neck were cytogenetically investigated. Three tumours were acinic cell carcinomas, two adenoid cystic carcinomas, three mucoepidermoid carcinomas, two carcinomas in pleomorphic adenoma, and two adenocarcinomas. Clonal chromosome aberrations were detected in all but one adenocarcinoma. Including our data, a total of 40 head and neck NSCCs with clonal aberrations have been described. Deletions of the long arm of chromosome 6 are the most common aberrations (11/40 cases); they have been detected in all types of NSCC except carcinoma in pleomorphic adenoma. Two aberrations seem to be closely associated with tumour type: t(6;9)(q21-24;p13-23), which has been seen in three of 11 adenoid cystic carcinomas (in two as the sole aberration), and structural rearrangements of 8q12-13, which have been detected in three of four carcinomas in pleomorphic adenoma.
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Y
Y
Jin
F
F
Mertens
J
J
Limon
N
N
Mandahl
J
J
Wennerberg
M
M
Dictor
S
S
Heim
F
F
Mitelman
D000230:Adenocarcinoma / Q000235:genetics; D008949:Adenoma, Pleomorphic / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D018267:Carcinoma, Acinar Cell / Q000235:genetics; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007766:Lacrimal Apparatus Diseases / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000235:genetics; D010307:Parotid Neoplasms / Q000235:genetics; D010610:Pharyngeal Neoplasms / Q000235:genetics; D013365:Submandibular Gland Neoplasms / Q000235:genetics; D014178:Translocation, Genetic