Leukotrien B4-induced interleukin-1 beta in synovial cells from patients with rheumatoid arthritis.
We examined the role of Leukotrien B4 (LTB4) in the production of Interleukin-1 beta (IL-1 beta) by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis. The production of IL-1 beta was augmented by LTB4 at concentrations of 10(-9) to 10(-8) M. Furthermore, LTB4 showed the additive effect on the IL-1 beta production with interferon-gamma but not with lipopolysaccharide. These results suggest that LTB4 in cooperation with certain cytokines might play a pivotal role in the IL-1 beta production by rheumatoid synovial cells in vivo.
Department of Orthopedics, Hamamatsu University School of Medicine, Japan.
Y
Y
Kageyama
Y
Y
Koide
S
S
Miyamoto
T O
TO
Yoshida
T
T
Inoue
D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007975:Leukotriene B4 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D009994:Osmolar Concentration; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
D007375:Interleukin-1; D008070:Lipopolysaccharides; D007975:Leukotriene B4