Heritability of schizophrenia. A controlled family history investigation in Nigeria.
Thirty-six consecutively admitted patients with schizophrenia and 20 with mania were studied for the morbid risk of psychosis in their first-degree relatives. Using the family history method of ascertainment, the morbid risk for schizophrenia in the relatives of schizophrenic probands was 4.12% compared with 1.42% in the relatives of manic probands. While this difference was not statistically significant, that between the morbid risk for affective psychoses in the relatives of manic patients (7.81%) was significantly higher than for the relatives of schizophrenic patients (0%).
Gureje
O
O
Department of Psychiatry, University College Hospital, Ibadan, Nigeria.
Bamidele
R
R
Aderibigbe
Y A
YA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics / Q000523:psychology; D003906:Developing Countries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010552:Personality Assessment; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D012565:Schizophrenic Psychology