Autologous bone marrow transplantation in Ki-1 lymphoma with poor prognosis. A case report.
The authors report a case of 17-years-old woman suffering from a Ki-1 lymphoma with retroperitoneal bulky disease, extranodal involvement, poor performance status and high level of LDH. Due to the unfavorable prognosis, after complete remission obtained with aggressive induction therapy, the patient received high dose of therapy based on busulfan and etoposide followed by autologous bone marrow transplantation (ABMT) as consolidation therapy. Toxicity was mild, particularly neutrophil recovery was hastened with G-CSF. After 22 months from ABMT she is alive without evidence of disease.
Cattedra e Servizio di Oncologia Medica, II Università, Napoli.
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Saieva
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Catalano
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012074:Remission Induction; D014182:Transplantation, Autologous