Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes.
Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains approximately 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.
University of Texas Health Science Center at San Antonio, Department of Medicine/Endocrinology 78284-7877.
J Q
JQ
Feng
M A
MA
Harris
N
N
Ghosh-Choudhury
M
M
Feng
G R
GR
Mundy
S E
SE
Harris
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins