Comparative evaluation of iohexol and inulin clearance for glomerular filtration rate determinations.
We evaluated iohexol as a filtration marker in 150 children. The clearance of iohexol was compared with that of inulin or with a formula clearance. The single-sample clearance of iohexol showed a good correlation with the clearance of inulin (r = 0.834). The clearance of iohexol correlated well (r = 0.672) with the formula clearance. The optimal blood sampling time for iohexol clearance determinations appears to be between 120 and 180 min after injection, at least in patients with relatively normal filtration rates. We conclude that iohexol clearance is an accurate method of determining the glomerular filtration rate in clinical practice.
Department of Paediatrics, Huddinge University Hospital, Karolinska Institute, Sweden.
H G
HG
Lindblad
U B
UB
Berg
D002675:Child, Preschool; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007444:Inulin; D007472:Iohexol; D008297:Male; D013052:Spectrometry, X-Ray Emission
D007472:Iohexol; D007444:Inulin