A case of pulmonary amyloidosis associated with multiple myeloma successfully treated with dimethyl sulfoxide.
A 57-year-old man with IgG multiple myeloma developed pulmonary infiltration caused by pulmonary amyloidosis, for which continuous transdermal dimethyl sulfoxide (DMSO) treatment was given. After 8 weeks from the start of DMSO treatment, a dramatic reduction of pulmonary infiltration as determined by chest roentgenogram was observed, and arterial blood gas levels were improved. No serious side effect of DMSO was encountered. We conclude that a therapeutic trial with transdermal DMSO administration brought about a marked regression of the pulmonary infiltrate.
Second Department of Internal Medicine, Hyogo College of Medicine, Japan.
T
T
Iwasaki
T
T
Hamano
K
K
Aizawa
K
K
Kobayashi
E
E
Kakishita
D000279:Administration, Cutaneous; D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D017809:Fatal Outcome; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction; D013997:Time Factors
D004121:Dimethyl Sulfoxide