[The use of monoclonal antibodies to lipid A for the correction of the hemodynamic disorders in endotoxemia].
Endotoxemia induced by gram-negative bacteria leads to endotoxic shock pathogenetically stemming from the integral component of the bacterial wall--lipid A. The study made to define the ability of lipid A monoclonal antibodies to correct hemodynamic disturbances due to endotoxemia in dog experiments showed the efficacy of the antibodies administration. ReLPS isolated from Salmonella Minnesota was used as an antigen. Administration of the complex monoclonal antibodies-endotoxin caused no hemodynamic impairment.
Rumiantsev
A G
AG
Kasatkin
V N
VN
Blokhin
B M
BM
Golubykh
V L
VL
Borovikov
D V
DV
Vlasik
T N
TN
Kanaeva
E S
ES
Kalantarov
G F
GF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000627:therapeutic use*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics / Q000187:drug effects; D007114:Immunization; D007075:Immunoglobulin M / Q000302:isolation & purification / Q000627:therapeutic use*; D008050:Lipid A / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D012475:Salmonella / Q000276:immunology; D012772:Shock, Septic / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D008050:Lipid A; D008070:Lipopolysaccharides; C085483:Re lipopolysaccharide
Ispol'zovanie monoklonal'nykh antitel k lipidu A dlia korrektsii gemodinamicheskikh narusheniĭ pri éndotoksemii.