Presence of anti-CSL antibodies in the cerebrospinal fluid of patients: a sensitive and specific test in the diagnosis of multiple sclerosis.
The carbohydrate-binding protein (lectin) CSL is an antigen involved in the stabilization of the myelin structure by interacting with the carbohydrate moiety of myelin glycoproteins. Since anti-CSL Fab fragments were able to produce destruction of CNS myelin in vitro, CSL was considered as a potential immunological target in multiple sclerosis. The presence of anti-CSL antibodies has been examined in the cerebrospinal fluid of 1388 different patients with various neurological diseases. It is concluded that the presence of anti-CSL antibodies in the cerebrospinal fluid of patients less than 50 years old constitutes a very sensitive and specific test for multiple sclerosis.
LNMIC CNRS UPR 416, Centre de Neurochimie, Strasbourg, France.
J P
JP
Zanetta
C
C
Tranchant
S
S
Kuchler-Bopp
S
S
Lehmann
J M
JM
Warter
D000906:Antibodies / Q000134:cerebrospinal fluid*; D006801:Humans; D015151:Immunoblotting; D037102:Lectins / Q000276:immunology*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology; D012680:Sensitivity and Specificity
D000906:Antibodies; D037102:Lectins; C059525:cerebellar soluble lectin