Cutaneous ultraviolet radiation inhibits herpes simplex virus-induced lymphoproliferation in latently infected subjects.
Exposure of herpes simplex virus (HSV) latently infected subjects to ultraviolet irradiation (UVR) (1 minimum erythema dose, 90% body surface) caused a significant inhibition of HSV and phytohemagglutinin-induced lymphoproliferation. The inhibition was observed on Day 3 post-UVR and lasted at least 9 days. UVR-induced downregulation of HSV-specific lymphoproliferation was associated with increased levels of activated transforming growth factor beta. However, the relationship between UVR-induced immune downregulation and the development of recurrent HSV lesions was incomplete.
Miura
S
S
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201.
Kulka
M
M
Smith
C C
CC
Imafuku
S
S
Burnett
J W
JW
Aurelian
L
L
D000328:Adult; D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D016207:Cytokines / Q000502:physiology*; D005260:Female; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins; D012867:Skin / Q000276:immunology / Q000528:radiation effects*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays; D014709:Vero Cells; D017735:Virus Latency / Q000276:immunology
D016207:Cytokines; D015850:Interleukin-6; D010835:Phytohemagglutinins; D016212:Transforming Growth Factor beta; D016753:Interleukin-10