Functional circulation and blood-brain permeability images by Angio CT in the assessment of cerebral ischemia.
We performed rapid sequential computerized tomography (CT) scanning following i.v. injection of a bolus of contrast medium, and generated three functional images related, respectively, to intravascular circulation time (rABCT), vascular volume density (Vv) and blood-brain barrier (BBB) unidirectional constant uptake rate (Ki). This was accomplished by calculating the first mathematical moment of the monitored time-density curves about the injection time, and by the multiple time graph analysis described by Patlack and coworkers. A satisfactory resolution was achieved, allowing separate appreciation of changes in rABCT both at large vessels and at tissue small vessels. Combined evaluation of rABCT and Vv images allowed us to draw qualitative conclusions about blood flow and perfusion reserve.
Institute of Clinical Neurology, University of Genoa, Italy.
A
A
Bartolini
B
B
Gasparetto
M
M
Furlan
A
A
Primavera
R
R
Amore
L
L
Sullo
G
G
Trivelli
D001488:Basilar Artery / Q000000981:diagnostic imaging; D001810:Blood Volume / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002533:Cerebral Angiography / Q000379:methods*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D003626:Data Display; D006801:Humans; D010539:Permeability; D011856:Radiographic Image Enhancement; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014711:Vertebral Artery / Q000000981:diagnostic imaging
D003287:Contrast Media