Internalization of surface components during Fc-receptor mediated phagocytosis by macrophages.
Mouse peritoneal resident macrophages efficiently ingest IgG-coated erythrocytes through a phagocytic process mediated by Fc-receptors. During this process surface components of the macrophages, which can be labeled by cationized ferritin and gold-labeled lectins are not interiorized together with the IgG-coated erythrocytes. However, they are internalized through endocytic vesicles and concentrated into vacuoles which are part of the endosomal-lysosomal system. Later on some of these components either are recycled back to the cell surface or are released, due to a process of lysosome-phagosome fusion, into the erythrocyte-containing phagosomes.
Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
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D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D002462:Cell Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000276:immunology; D005614:Freeze Fracturing; D017979:Gold Colloid; D007074:Immunoglobulin G / Q000097:blood; D007150:Immunohistochemistry; D037102:Lectins; D017737:Macrophages, Peritoneal / Q000502:physiology*; D051379:Mice; D010587:Phagocytosis / Q000502:physiology*; D011961:Receptors, Fc / Q000502:physiology*; D012756:Sheep
D015415:Biomarkers; D017979:Gold Colloid; D007074:Immunoglobulin G; D037102:Lectins; D011961:Receptors, Fc