The inositol phosphate-calcium signalling system in lacrimal gland cells.
From the above discussion, it is clear that the regulation of Ca2+ signalling in exocrine cells is a complex process involving activation of both intracellular Ca2+ release as well as the entry of Ca2+ across the plasma membrane. A poorly understood mechanism links these two phases of Ca2+ signalling thereby providing both rapid as well as sustained signals for the initiation and maintenance of appropriate exocrine responses. Further work is needed to better understand the mechanisms controlling this important and ubiquitous signalling system.
Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences-NIH, Research Triangle Park, NC 27709.
J W
JW
Putney
G S
GS
Bird
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology*; D007295:Inositol Phosphates / Q000502:physiology; D007765:Lacrimal Apparatus / Q000166:cytology / Q000502:physiology*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*
D007295:Inositol Phosphates; C081655:inositol-1,3,4,5-tetrakisphosphate; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium