Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins.
Recent progress in our understanding of the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) has provided the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year have indicated that the activity of the NADPH oxidase can be modulated by regulation of the GTP/GDP state of Rac. Proteins exist in leukocytes that are able to modify GTP-binding protein function in this manner, and their activity may be regulated by signals generated upon phagocyte stimulation.
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
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Bokoch
D000818:Animals; D002634:Chemotaxis, Leukocyte; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000097:blood; D006160:Guanosine Triphosphate / Q000097:blood; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D009247:NADH, NADPH Oxidoreductases / Q000097:blood*; D019255:NADPH Oxidases; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D020744:rac GTP-Binding Proteins
D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins