[The occurrence of immunological tolerance to inhibitors of factors VIII and IX in hemophilia patients].
To abolish inhibitors, 40 out of 60 hemophiliacs (57 patients and 3 with hemophilia A and B, respectively) were treated according to the therapeutic scheme specified as Bonn protocol. A complete disappearance of the inhibitors was achieved in all the patients. These were followed up for 13 years during which they received on demand standard hemostatic treatment. No inhibitors have been registered so far.
Brakman
G G
GG
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005164:Factor IX / Q000008:administration & dosage / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000276:immunology; D005169:Factor VIII / Q000008:administration & dosage / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000276:immunology; D015483:HIV Antibodies / Q000097:blood; D006679:HIV Seropositivity / Q000453:epidemiology; D015497:HIV-1 / Q000276:immunology; D006467:Hemophilia A / Q000150:complications / Q000276:immunology* / Q000628:therapy; D002836:Hemophilia B / Q000150:complications / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
D015483:HIV Antibodies; D005169:Factor VIII; D005164:Factor IX
Vozniknovenie immunologicheskoĭ tolerantnosti k ingibitoram faktorov VIII i IX u bol'nykh gemofilieĭ.