The prismatic case of apparent mineralocorticoid excess.
A personal memoir of the discovery of a new form of hypertension, apparent mineralocorticoid excess, came about through painstaking analysis of the symptoms of a Zuñi Indian girl. The study of this patient opened a new field of receptor biology, i.e. how glucocorticoids and mineralocorticoids interact with receptors. Therefore, the patient was a prismatic case.
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Department of Pediatrics, New York Hospital-Cornell Medical Center, New York 10021.
D042842:11-beta-Hydroxysteroid Dehydrogenases; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000172:deficiency; D006973:Hypertension / Q000150:complications*; D007008:Hypokalemia / Q000150:complications*; D007198:Indians, North American; D008661:Metabolism, Inborn Errors; D008901:Mineralocorticoids / Q000378:metabolism*; D018161:Receptors, Mineralocorticoid / Q000378:metabolism
D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D006854:Hydrocortisone