Position-effect variegation and the new biology of heterochromatin.
The phenomenon of position-effect variegation has long been used as evidence for the importance of chromosome position to gene expression in eukaryotes. Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems.
Karpen
G H
GH
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037-1099.
D000818:Animals; D002503:Centromere; D002843:Chromatin / Q000502:physiology; D004247:DNA; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation; D006570:Heterochromatin; D006801:Humans; D016615:Telomere
D002843:Chromatin; D006570:Heterochromatin; D004247:DNA