[The use of antioxidants (alpha-tocopherol acetate) in the treatment of diabetes mellitus].
The authors have examined the time course of lipid peroxidation processes and the levels of total lipids in red cell membranes and blood plasma of diabetics administered alpha-tocopherol acetate. Patients with medium-severe diabetes of the first and second types were divided into 2 groups. Group 1 patients were administered only traditional sugar-reducing treatment, in Group 2 alpha-tocopherol acetate in a daily dose 300 mg was added to such therapy. Similar examinations were carried out in both the groups before and after the treatment. Lipid peroxidation levels and the content of total lipids were found significantly increased in the cellular membranes and blood plasma of Group 2 patients, whereas in Group 1 no changes of this kind were detected. Therapy with alpha-tocopherol acetate normalized lipid peroxidation processes in the red cell membranes and the total lipid content in the blood plasma, reduced the blood plasma level of lipid peroxidation products and the content of total lipids in red cell membranes. These results permit a conclusion on the favorable effect of alpha-tocopherol acetate on blood plasma lipid peroxidation and total lipid levels in diabetics.
Kuznetsov
N S
NS
Abulela
A M
AM
Neskoromnyĭ
V N
VN
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D008055:Lipids; D008563:Membrane Lipids; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols
O primenenii antioksidantov (al'fa-tokoferola atsetata) v lechenii sakharnogo diabeta.