[The experimental studies on concomitant occlusion of the superior mesenteric artery during intraarterial chemotherapy of the liver].
We investigated the effect of temporary occlusion of the superior mesenteric artery (SMAO) on the hepatic tissue concentration of anticancer drugs in hepatic artery infusion. Adriamycin (ADR: 1 mg/kg weight) was continuously administered into the hepatic artery for five minutes in dogs. Depending on the use and method of vascular occlusion, animals were allocated into five groups and hepatic tissue ADR levels were determined: Group I, SMAO; Group II, no vascular occlusion; Group III, occlusion of the common hepatic artery (CHAO); Group IV, combined SMAO and CHAO; Group V, occlusion of the portal vein. The hepatic tissue ADR level at 10 minutes was significantly higher in Group I than those in Group II and III. The tissue ADR level in Group IV and V tended to be slightly higher than in Group I, although there is no statistically significant difference. These results indicate that SMAO may provide a useful means of increasing local drug level during regional chemotherapy of the liver.
First Department of Surgery, Kobe University School of Medicine.
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M
Samizo
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Ku
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Saito
D000818:Animals; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006499:Hepatic Artery; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008099:Liver / Q000378:metabolism*; D008297:Male; D017538:Mesenteric Artery, Superior
D004317:Doxorubicin