Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration.
A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.
Asada
H
H
Department of Dermatology, Osaka University School of Medicine, Suita, Japan.
Okada
N
N
Tei
H
H
Yamamura
T
T
Hashimoto
K
K
Kondo
K
K
Yamanishi
K
K
Yoshikawa
K
K
D000328:Adult; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006566:Herpesviridae Infections / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D015458:Leukemia, T-Cell / Q000382:microbiology* / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*
D004279:DNA, Viral