Morphological aspects of an experimental tumour photosensitized with a meso-substituted cationic porphyrin.
The meso-substituted cationic porphyrin, meso-tetra(4N-methyl-pyridyl)porphine (T4MPyP) appears to be a selective tumour localizer on the basis of pharmacokinetic studies. Irradiation (at 600-680 nm) of an intramuscularly implanted MS-2 fibrosarcoma in Balb/c mice at 24 h after injection of T4MPyP causes tumour necrosis: histological and ultrastructural analyses of tumour specimens taken at different times after phototherapy indicate slowly-appearing tissue damage which involves both malignant cells and the vascular endothelium. At the subcellular level, the membranous systems and nuclei are the main targets of the photoprocess. The tumour necrosis is particularly extensive upon injection of 4.1 mg kg-1 T4MPyP.
Departamento de Biologia, Universidad Autonoma de Madrid, Spain.
A
A
Villanueva
L
L
Caggiari
G
G
Jori
C
C
Milanesi
D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005354:Fibrosarcoma / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology / Q000648:ultrastructure; D008652:Mesoporphyrins / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009336:Necrosis; D010778:Photochemotherapy; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013997:Time Factors
D008652:Mesoporphyrins; D011166:Porphyrins; C021096:tetra(4-N-methylpyridyl)porphine