[Effect of platelet-activating factor (PAF) on eosinophil adhesion to plasma-coated glass using eosinophilic cell lines (EoL-1, EoL-3)].
Adhesion molecules on various inflammatory cells, especially on eosinophils are now considered to play an important role in allergic inflammations such as bronchial asthma. In this study, we examined the effect of platelet-activating factor (PAF) on eosinophil adhesion to plasma-coated glass using eosinophilic cell lines (EoL-1, EoL-3), since PAF might be an important mediator as an eosinophil chemotactic agent in bronchial asthma. PAF markedly augmented adherence to plasma-coated plates. This finding suggests that PAF might up-regulate the inflammatory reaction in bronchial asthma through its action as an augmentative agent for eosinophil adhesion as well as its action as an eosinophil chemotactic agent.
Fourth Department of Internal Medicine, Kinki University School of Medicine.
T
T
Kakazu
J
J
Chihara
A
A
Saito
N
N
Hayashi
I
I
Higashimoto
D
D
Kurachi
T
T
Yamamoto
S
S
Nakajima
D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D004804:Eosinophils / Q000502:physiology*; D005898:Glass; D006801:Humans; D010949:Plasma; D010972:Platelet Activating Factor / Q000494:pharmacology*
D010972:Platelet Activating Factor