Rhinocerebral zygomycosis in acute lymphoblastic leukaemia.
We describe a patient with acute lymphoblastic leukaemia who developed rhinocerebral zygomycosis during the aplastic phase induced by antineoplastic chemotherapy. The patient was treated with fluconazole intravenously (400 mg daily) for 30 days and underwent surgical debridement. As a result of this treatment a complete remission of the zygomycosis-associated symptoms was observed. The possibility of treating zygomycosis with fluconazole is discussed.
Istituto di Semeiotica Medica, Università Cattolica del S. Cuore, Rome, Italy.
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S
Sica
G
G
Morace
L M
LM
La Rocca
B
B
Etuk
A
A
Di Mario
L
L
Pagano
G
G
Zini
S
S
Rutella
G
G
Leone
D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000382:microbiology / Q000601:surgery / Q000628:therapy; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D009091:Mucormycosis / Q000150:complications* / Q000601:surgery / Q000628:therapy; D009668:Nose Diseases / Q000150:complications* / Q000382:microbiology / Q000601:surgery / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*
D015725:Fluconazole