A new UV-filter compound in human lenses.
A new UV-filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside, has been identified in human lenses. The structure suggests that it is derived biosynthetically from tryptophan. Quantification studies on the new compound show that it is the second-most abundant UV-filter compound in the lens with an absorption and fluorescence spectrum similar to that of 3-hydroxykynurenine glucoside.
Truscott
R J
RJ
Australian Cataract Research Foundation, University of Wollongong, N.S.W.
Wood
A M
AM
Carver
J A
JA
Sheil
M M
MM
Stutchbury
G M
GM
Zhu
J
J
Kilby
G W
GW
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003459:Crystallins / Q000737:chemistry / Q000302:isolation & purification*; D005374:Filtration; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007908:Lens, Crystalline / Q000737:chemistry*; D015394:Molecular Structure; D010654:Phenylbutyrates / Q000737:chemistry / Q000302:isolation & purification*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
D003459:Crystallins; D005960:Glucosides; D010654:Phenylbutyrates; C088377:4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside