[Syngeneic transplantation of nasal mucosa and azathioprine medication for therapy of cicatricial ocular mucous membrane pemphigoid. Study of 9 patients with 11 eyes].
Nine patients (11 eyes) with ocular cicatricial pemphigoid were treated with systemic azathioprine and a syngeneic nasal mucosa transplant from the inferior turbinate. Follow-up was 8-26 months (average 15 months). Grafting was successful in all cases. Treatment ameliorated the symptoms of pain in all patients and double vision in one. In 2 eyes in which simultaneous pannus resection had been performed, neither pannus nor corneal vascularization recurred. Late complications were recurrences with symblephara in two cases when azathioprine was stopped; in one patient with a serpiginous ulcer tectonic penetrating keratoplasty à chaud had to be performed; and in another a trophic ulcer was healed with a therapeutic contact lens.
Bialasiewicz
A A
AA
Augenklinik mit Poliklinik, Universität Münster.
Förster
W
W
Radig
H
H
Hüttenbrink
K B
KB
Grewe
S
S
Busse
H
H
D000368:Aged; D000369:Aged, 80 and over; D001379:Azathioprine / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003231:Conjunctivitis / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000637:transplantation*; D010390:Pemphigoid, Benign Mucous Membrane / Q000473:pathology / Q000601:surgery*; D012008:Recurrence
D001379:Azathioprine
Syngene Nasenschleimhauttransplantation und Azathioprinmedikation zur Therapie des vernarbenden okularen Schleimhautpemphigoids. Studie an 9 Patienten mit 11 Augen.