On the optimization of the physicochemical distances between amino acids in the evolution of the genetic code.
Using the simulated annealing technique we re-examine the role played by the minimization of the physicochemical distances between amino acids during the origin of the organization of the genetic code. The results are discussed in the context of the various hypotheses proposed to explain how amino acids were allocated in the genetic code.
Di Giulio
M
M
International Institute of Genetics and Biophysics, CNR, Napoli, Italy.
Capobianco
M R
MR
Medugno
M
M
D000595:Amino Acid Sequence; D000596:Amino Acids; D000818:Animals; D005075:Biological Evolution; D005815:Genetic Code; D008957:Models, Genetic
D000596:Amino Acids