Myocardial salvage by chimyl alcohol: possible role of peroxisomal dysfunction in reperfusion injury.
The results of this study suggest that reperfusion of ischemic myocardium may lead to the peroxisomal disorder both functionally and biochemically. An alkyl glycerol such as chimyl alcohol can protect the ischemic heart from the reperfusion injury probably by enhancing the plasmalogen synthesis.
Department of Surgery, University of Connecticut School of Medicine, Farmington 06030.
N
N
Maulik
A
A
Tosaki
R M
RM
Engelman
G A
GA
Cordis
D K
DK
Das
D000818:Animals; D002374:Catalase / Q000378:metabolism; D005995:Glyceryl Ethers / Q000494:pharmacology*; D008830:Microbodies / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D010955:Plasmalogens / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D005995:Glyceryl Ethers; D010955:Plasmalogens; D002374:Catalase; C004348:chimyl alcohol