Effects of several amnesic drugs on the habituation of exploratory activity in mice as indexed by horizontal and vertical activities.
1. The effects of several drugs on the habituation of exploratory activity in mice were investigated by using animal movement analyzing systems which could detect horizontal and vertical activities. 2. Habituation was regarded as the difference between exploratory activity measured first (session 1) and that measured second (session 2). 3. Scopolamine (1, 3 and/or 6 mg/kg), pirenzepine (20 and 40 micrograms) injected immediately after session 1, cycloheximide (30 mg/kg), diazepam (1, 2 and/or 4 mg/kg) and dizocilpine (0.05, 0.1 and/or 0.2 mg/kg), unlike butylscopolamine (1, 3 and 6 mg/kg) or haloperidol (0.2 and 0.4 mg/kg), significantly increased horizontal activity but not always vertical activity in session 2. 4. From the results obtained, it appears that the increase in horizontal activity in session 2 is more appropriate as an indicator of the impairments of memory processes than that in vertical activity.
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
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Ukai
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Kobayashi
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Kameyama
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D010890:Pirenzepine / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology
D002086:Butylscopolammonium Bromide; D010890:Pirenzepine; D016291:Dizocilpine Maleate; D003513:Cycloheximide; D012601:Scopolamine; D006220:Haloperidol; D003975:Diazepam