Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine.
Simian immunodeficiency virus (SIV) infection of macaques is a useful and relevant model for evaluating candidate human immunodeficiency virus (HIV) vaccines. One important feature of this model is that SIV vaccines can be evaluated for their ability to prevent infection as well as to prevent or delay the onset of AIDS. In the present study, a group of macaques was vaccinated with whole inactivated SIV and challenged with peripheral blood mononuclear cells from an SIV-infected macaque. This challenge represented a rigorous and realistic test of the immunization protocol. All macaques became infected after challenge; however, immunized animals survived significantly longer (P < .03) than naive controls. These data suggest that similar vaccines administered to humans at risk for HIV-1 infection might delay or prevent AIDS even if the vaccine failed to prevent infection.
Immunodeficiency Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
V M
VM
Hirsch
S
S
Goldstein
N A
NA
Hynes
W R
WR
Elkins
W T
WT
London
P M
PM
Zack
D
D
Montefiori
P R
PR
Johnson
D016915:AIDS Vaccines; D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D001483:Base Sequence; D002478:Cells, Cultured; D004279:DNA, Viral; D006801:Humans; D008254:Macaca nemestrina; D008969:Molecular Sequence Data; D009000:Monocytes / Q000382:microbiology; D017386:Sequence Homology, Amino Acid; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D017735:Virus Latency
D016915:AIDS Vaccines; D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines