[The mebendazole treatment of patients with alveolar echinococcosis].
Chemotherapy was administered to 17 alveolar echinococcosis patients. Two of these patients developed an uncomplicated disease (a subtotal involvement of both liver lobes), fifteen a complicated condition. In 13 patients with the complicated condition metastases to the lungs, peritoneum, as well as diaphragmatic and abdominal organs' growth were detected, in 4 ones jaundice developed. Mebendazole was administered in a daily dose of 50 mg/kg together with the drugs improving its absorption. 30-day courses with 1-3 month intervals were administered. The efficacy of this therapy and its tolerance were assessed from clinical, laboratory and instrumental findings, including serologic tests. Intolerance presenting as alopecia was observed in 4 women, in one of them twice. Mebendazole efficacy in these patients was compared to that in patients administered the drug in a daily dose of 100 mg in 1978-1980. A positive time course was observed in 53% of patients.
A M
AM
Shcherbakov
E Ia
EIa
Panteleeva
R A
RA
Firsova
D000293:Adolescent; D000328:Adult; D004341:Drug Evaluation; D004444:Echinococcosis, Hepatic / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D004445:Echinococcosis, Pulmonary / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D013997:Time Factors
D008463:Mebendazole
Lechenie mebendazolom bol'nykh al'veoliarnym ékhinokokkozom.