Chrymutasins: novel-aglycone antitumor antibiotics from a mutant of Streptomyces chartreusis. I. Taxonomy, mutation, fermentation, isolation and biological activities.
Three novel antibiotics, named chrymutasins A, B and C, were isolated from the fermentation products of a mutant strain obtained by NTG (N-methyl-N'-nitro-N-nitrosoguanidine) treatment. The mutant strain produced the chrymutasins, which differed in the aglycone moiety from chartreusin, and related compounds. The production of these compounds needed a characteristically long fermentation period. The antitumor activity of chrymutasin A is better in vivo than that of chartreusin, the cytotoxic activity against cell lines in vitro is equivalent, and the antimicrobial spectrum is narrower.
Uchida
H
H
Pharmaceutical Research Laboratories, Sapporo Breweries Ltd., Shizuoka, Japan.
Nakakita
Y
Y
Enoki
N
N
Abe
N
N
Nakamura
T
T
Munekata
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D016296:Mutagenesis; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013302:Streptomyces / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015003:Yeasts / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D006027:Glycosides; C088439:chrymutasin A; C088440:chrymutasin B; C088441:chrymutasin C