Oxygen radicals generation and DNA scission by anticancer and synthetic quinones.
Weiner
L M
LM
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.
D000970:Antineoplastic Agents; D003497:Cyclic N-Oxides; D004249:DNA Damage; D003630:Daunorubicin; D004317:Doxorubicin; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D017665:Hydroxyl Radical / Q000032:analysis*; D007700:Kinetics; D016685:Mitomycin; D015394:Molecular Structure; D009243:NAD; D009249:NADP; D009251:NADPH-Ferrihemoprotein Reductase; D010084:Oxidation-Reduction; D011809:Quinones; D013056:Spectrophotometry, Ultraviolet; D013113:Spin Labels; D013481:Superoxides / Q000032:analysis*
D000970:Antineoplastic Agents; D003497:Cyclic N-Oxides; D011809:Quinones; D013113:Spin Labels; D009243:NAD; D013481:Superoxides; D017665:Hydroxyl Radical; D016685:Mitomycin; D009249:NADP; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D004317:Doxorubicin; D009251:NADPH-Ferrihemoprotein Reductase; D003630:Daunorubicin