8-OH-DPAT induces a selective increase in protein intake in ageing overweight animals.
We have examined the effects of a 5-HT1A receptor agonist (8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT) on food preference in ageing rats that had been given a 'palatable' meal 15 min before administration of the drug. Ageing rats consumed a greater amount of the 'palatable' pre-meal than the young rats. In young rats lipids were the predominant source of calories, but in old animals lipid and protein consumption was similar. Administration of 8-OH-DPAT resulted in an increase in total caloric intake in both groups. Concomitant with this there was a significant increase in protein intake in both groups, which was most important in ageing rats, where proteins became the predominant source of calories.
Lacour
F
F
Division of Metabolic Diseases, Institut de Recherches Servier, Suresnes, France.
Berger
S
S
Espinal
J
J
Duhault
J
J
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000375:Aging / Q000523:psychology*; D000818:Animals; D004032:Diet; D004044:Dietary Proteins; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects; D015228:Hypertriglyceridemia / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000523:psychology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004044:Dietary Proteins; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin