Cimetidine-induced myelosuppression after bone marrow transplantation.
A strong temporal correlation was observed between cessation of cimetidine and a sustained increase in blood counts in two marrow transplant recipients. Both were receiving cimetidine from the day of transplantation for prophylaxis of stress ulceration and gastritis. The blood counts of both patients were not increasing satisfactorily 5-6 weeks after marrow transplantation without any obvious cause of marrow suppression. A similar observation has been made with the use of ranitidine after marrow transplantation suggesting that histamine H2-receptor antagonists should be used very cautiously, if at all, in the setting of bone marrow transplantation.
Leukemia Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
J
J
Mehta
R L
RL
Powles
J
J
Treleaven
M
M
Shields
S
S
Agrawal
K
K
Rege
P
P
Mitchell
S
S
Allard
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000502:physiology*; D002927:Cimetidine / Q000009:adverse effects*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000628:therapy*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000628:therapy*; D007958:Leukocyte Count / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D013997:Time Factors
D002927:Cimetidine