Modelling of interhelical contacts in interferons-beta, -gamma, and dimeric interleukin-5.
On the basis of crystallographic data, the alpha-helices of interferon-beta as well as each domain of interferon-gamma are located in two layers. This results in a different contribution from the amino acids placing in the middle and border alpha-helices of the layer to the hydrophobic core of the molecule. A close analysis of the structure of dimeric interleukin-5 shows related arrangements of alpha-helices. The full schemes of the interhelix contacts of interferons-beta, -gamma, and dimeric interleukin-5 were constructed. Schemes for interleukin-5 show that extension of helices correlates with the dimer topology.
Institute of Immunology, Moscow Region, Russia.
A I
AI
Denesyuk
V P
VP
Zav'yalov
T
T
Korpela
D003198:Computer Simulation; D016899:Interferon-beta / Q000737:chemistry / Q000648:ultrastructure*; D007371:Interferon-gamma / Q000737:chemistry / Q000648:ultrastructure*; D015848:Interleukin-5 / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012995:Solubility
D015848:Interleukin-5; D016899:Interferon-beta; D007371:Interferon-gamma