Use of antibiotic-PMMA beads in the ischemic foot.
Thirty-six patients with 44 ischemic foot infections were managed with antibiotic-polymethylmethacrylate (PMMA) beads. Most of these patients received gentamicin-impregnated PMMA beads but tobramycin and vancomycin-impregnated PMMA beads were used on three patients. Angiopathy occurred in 35 patients secondary to diabetes and secondary to renal disease in 2; 1 patient had both diabetes and renal disease. The most common bacteria was Staphylococcus aureus (82%), although other organisms and multiple bacteria were present. In spite of the variability of the bacteria, PMMA beads were helpful in managing foot infections in this difficult patient population.
Calhoun
J H
JH
Div of Orthopedic Surgery, University of Texas Medical Branch, Galveston 77555-0792.
Klemm
K
K
Anger
D M
DM
Mader
J T
JT
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005528:Foot / Q000098:blood supply*; D005534:Foot Diseases / Q000188:drug therapy* / Q000382:microbiology; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000209:etiology; D007511:Ischemia / Q000150:complications*; D008297:Male; D008768:Methylmethacrylates / Q000627:therapeutic use*; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D004343:Drug Implants; D005839:Gentamicins; D008768:Methylmethacrylates; C030159:gentamicin-polymethylmethacrylate bead