Parental imprinting of autosomal mammalian genes.
The molecular mechanisms introducing epigenetic modifications that lead to differential silencing of some autosomal alleles depending on their parental legacy are still largely unknown, but recent results from studies of endogenously imprinted genes and particular transgenes make DNA methylation a strong candidate. At the same time, these results have raised new questions about the details of the imprinting process.
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Department of Genetics and Development, Columbia University, New York, New York 10032.
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans