Cyclic GMP regulation of calcium slow channels in cardiac muscle and vascular smooth muscle cells.
The effects of cAMP and cGMP on the slow Ca2+ channels in cardiac muscle, VSM, and skeletal muscle fibers are summarized in Table V. As shown, in cardiac muscle, cAMP stimulates and cGMP inhibits. In VSM, both cAMP and cGMP inhibit. In skeletal muscle, both cAMP and cGMP stimulate.
Department of Physiology and Biophysics, College of Medicine, University of Cincinnati, Ohio 45267.
N
N
Sperelakis
N
N
Tohse
Y
Y
Ohya
H
H
Masuda
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology; D006152:Cyclic GMP / Q000494:pharmacology / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D000242:Cyclic AMP; D006152:Cyclic GMP