Response of calcitonin-gene-related peptide-like immunoreactive nerve fibers of the anterior pituitary to adrenalectomy in the rat.
The mammalian anterior pituitary is known to be regulated by humoral factors only, no direct neural influence having ever been discovered. Our recent studies have shown in several species that there are substantial amounts of substance P and calcitonin-gene-related peptide-like immunoreactive (CGRP-LI) nerve fibers in the anterior pituitary and that they can make synaptic contacts with secretory cells, among which corticotropes. In the present study, we investigated changes in CGRP-LI nerve fibers of the anterior pituitary after bilateral adrenalectomy in the rat. The results show that the number of CGRP-LI nerve fibers increases significantly. In parallel, they cover a wider area of the gland after the operation, suggesting a direct neural influence.
Department of Neurobiology, Fourth Military Medical University, Xi'an, PR China.
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D000315:Adrenalectomy; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D007124:Immunoenzyme Techniques; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure*; D010903:Pituitary Gland, Anterior / Q000648:ultrastructure*; D051381:Rats; D017207:Rats, Sprague-Dawley
D015740:Calcitonin Gene-Related Peptide