The effect of midazolam on median nerve somatosensory evoked potentials.
OBJECTIVE
To quantify the effect of an induction dose of midazolam on median nerve somatosensory evoked potentials.


METHODS
We studied 10 patients undergoing lumbar spine surgery. After an induction dose of intravenous midazolam was given, MNEPs were collected for ten minutes. After ten minutes the patients were intubated and their anesthetic was supplemented with 0.5% isoflurane, narcotic, and N2O.


RESULTS
We found a clinically significant decrease in amplitude and an insignificant delay in latency.


CONCLUSIONS
When midazolam is used as an anesthetic induction agent, a decrease in amplitude can be expected.
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
K
K
Lauer
C
C
Munshi
S
S
Larson
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D011229:Preanesthetic Medication; D011930:Reaction Time / Q000187:drug effects
D008874:Midazolam