[Influence of benzyl penicillin on cytotoxicity and level of metabolic activity of cyclophosphamide in mice].
The influence of benzylpenicillin on cytotoxicity of cyclophosphamide (CF) against leukaemia L 1210 was studied. The level of CF metabolites in mouse serum was traced. The benzylpenicillin appeared to enhance cytotoxic activity of CF and leads to increase of active metabolites when CF applied in high doses (300 mg/kg).
Zakład Farmakodynamiki, Katedra Farmakologii, Akademia Medyczna, Lódź.
W
W
Pakulska
J
J
Graczyk
D000818:Animals; D003520:Cyclophosphamide / Q000097:blood / Q000494:pharmacology*; D004357:Drug Synergism; D007939:Leukemia L1210 / Q000097:blood / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D010400:Penicillin G / Q000494:pharmacology*
D003520:Cyclophosphamide; D010400:Penicillin G
Wpływ benzylopenicyliny na cytotoksyczność i poziom aktywnych metabolitów cyklofosfamidu u myszy.