[Experimental study on bone formation induced by porous HA-beta-TCP bioceramics].
Three types of HA-beta-TCP active bioceramics which have various porosity and porous diameters were implanted into femurs and muscles of dogs. Histological and biomechanical tests proved that the porous HA-beta-TCP could make the active stage of bone formation moved up in bones and induce new bone formation in muscles. The pores were easily filled with new bones in samples which had smaller porous diameter than samples having larger porous diameter. The final strength after accomplishment of repair process was closely related with porosity. In samples with lower porosity, the proportion of organic bone and the strength were also lower, but in samples with higher porosity the proportion of organic bone and the strength were also higher. Up to the fourth month postoperatively, the strength of HA-beta-TCP with proper porous diameter and porosity which had been implanted into bones was as high as that of organic bone.
Chengdu Hospital, Air Force of PLA.
C
C
Zhang
D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001846:Bone Development; D002130:Calcium Phosphates; D002516:Ceramics; D004285:Dogs; D005260:Female; D005269:Femur / Q000473:pathology / Q000503:physiopathology; D006882:Hydroxyapatites; D008297:Male; D016062:Porosity
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485817:beta-tricalcium phosphate; C018392:tricalcium phosphate