[Comparative effectiveness of treatment of non-Hodgkin's lymphoma in children using protocols BFM NHL-90 and non-programmed courses based on the ACOP regimen].
170 NHL children aged 1-14 [mean age 6] have been treated for the last 5 years. The diagnostic examination included the disease history, physical examination, bone marrow cytology, tumor histology (all patients), immunophenotyping (17 cases), x-ray and sonography of the chest and abdomen. According to the International NHL staging system, 35% of the patients had NHL stage II, 65% stage III or IV. The study entered 71 patients who underwent additional lactate dehydrogenase test, CT-scanning. 44 of them received nonprogrammed therapy on the basis of ACOP (group I), 27 patients were treated according to BFM-NHL-90 for B-, non-B- and large-cell anaplastic lymphomas (group II). The efficiency of the methods did not differ for patients at stage IIR. At the II NR stage complete remission (CR) was up to 41% in the group I and 60% in the group II. 50% of the children from group I and 20% from the group II were resistant to treatment. All the group I patients developed relapses, none got relapses in the group II. CR was observed in 64% and 78% of patients from group I and II, respectively, who had NHL stage III and IV. Relapses occurred in 41% and 14%, respectively. CCR was in 22% in the group I and in 67% of the group II patients. Effectiveness of B-NHL treatment according to BFM protocols was higher than in other types of NHL as to the number of relapses and frequency of CCR: the latter was 76% compared to 50% of non-B-NHL.(ABSTRACT TRUNCATED AT 250 WORDS)
Lebedev
V V
VV
Karachunskiĭ
A I
AI
Kryzhanovskiĭ
O I
OI
Osokin
A G
AG
Rumiantsev
A G
AG
Samochatova
E V
EV
Belikova
L Iu
LIu
Gorban'
Zh I
ZhI
Kharit
M Ia
MIa
Maschan
A A
AA
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin
Sravnitel'naia éffektivnost' lecheniia nekhodzhkinskikh limfom u deteĭ po protokolam BFM NHL-90 i nonprogrammnym kursam na osnove rezhima ATsOP.