Extracorporeal membrane oxygenation: preliminary results in patients with postcardiotomy cardiogenic shock.
Long-term survival at our institution for postcardiotomy cardiogenic shock patients supported with the BioPump is 36% (29/80 patients). A heparin-coated extracorporeal membrane oxygenator (ECMO), first introduced in 1991, may reduce organ injury associated with cardiopulmonary bypass. The device can be employed rapidly because it connects directly to the cardiopulmonary bypass cannula. In an effort to improve our results in the treatment of postcardiotomy cardiogenic shock, we used ECMO in 21 patients with this syndrome and accompanying complications. The patients were divided into three groups: group 1, ECMO after coronary artery bypass grafting; group 2, ECMO after mitral valve operation; and group 3, ECMO after open heart operation with prolonged cardiac arrest. Survival in group 1 was 80% with 12 of 14 patients discharged to home. All three deaths were caused by cardiac failure. Bleeding complications in this group were moderate. There was no evidence of disseminated intravascular coagulation, and levels of fibrin split products remained within the normal range. Postoperative complications included stroke (2), renal failure (1), mediastinitis (1), and prolonged respiratory failure (6). Mortality in group 2 was 100%. The major problem limiting recovery was left ventricular distention secondary to inadequate left ventricular decompression. Mortality in group 3 was 100%; all 4 died of brain death. Extracorporeal membrane oxygenation without left ventricular drainage clearly is not effective in patients undergoing mitral valve operations as it does not effectively decompress the left ventricle, but it was highly effective in treating postcardiotomy cardiogenic shock in our coronary artery bypass grafting patients. Extracorporeal membrane oxygenation also proved to be safe as the patient-related complications of stroke, renal failure, and mediastinitis were low. Our preliminary success with heparin-coated ECMO now needs to be confirmed by studies from other centers with larger groups of patients.
Magovern
G J
GJ
Department of Surgery, Allegheny General Hospital, Medical College of Pennsylvania, Pittsburgh 15212.
Magovern
J A
JA
Benckart
D H
DH
Lazzara
R R
RR
Sakert
T
T
Maher
T D
TD
Clark
R E
RE
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000473:pathology; D002303:Cardiac Output, Low / Q000209:etiology / Q000628:therapy; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D001026:Coronary Artery Bypass / Q000009:adverse effects; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects; D006461:Hemolysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy; D007423:Intra-Aortic Balloon Pumping; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000601:surgery; D010107:Oxygenators, Membrane; D012770:Shock, Cardiogenic / Q000097:blood / Q000209:etiology / Q000628:therapy*; D015996:Survival Rate; D014693:Ventricular Fibrillation / Q000150:complications; D016277:Ventricular Function, Left / Q000502:physiology