Absence of APP713 mutation in Italian and Russian families with schizophrenia.
A recent study has shown a mutation at codon 713 of the amyloid precursor protein (APP) gene in a schizophrenic patient. We have analyzed the MaeIII restriction site caused by that mutation in Italian and Russian families with schizophrenia. No mutations were observed suggesting that the APP713 mutation is unlikely to be linked to the pathogenesis of such a psychiatric disorder.
Mortilla
M
M
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Amaducci
L
L
Bruni
A
A
Montesi
M P
MP
Trubnikov
A
A
De Cataldo
S
S
Pallanti
S
S
Pazzagli
A
A
Grecu
L
L
Servi
P
P
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D006801:Humans; D007558:Italy; D008969:Molecular Sequence Data; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012426:Russia; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D004247:DNA