Assessment of cysteinyl leukotriene synthesis in man.
We have developed methods to measure LTE4, the index metabolite of cysteinyl leukotrienes, by HPLC/RIA and GC/MS. Urinary LTE4 appears to be a reliable parameter to assess whole body cysteinyl leukotriene synthesis in man from all evidence available at this time. Measurement of this metabolite can be used to monitor effects of diseases and drugs on cysteinyl leukotriene synthesis in man.
Frölich
J C
JC
Department of Clinical Pharmacology, Hannover Medical School, Germany.
Fauler
J
J
Tsikas
D
D
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007700:Kinetics; D017997:Leukotriene C4 / Q000378:metabolism*; D017998:Leukotriene D4 / Q000378:metabolism; D017999:Leukotriene E4 / Q000032:analysis / Q000096:biosynthesis* / Q000652:urine; D011863:Radioimmunoassay / Q000379:methods
D017997:Leukotriene C4; D017998:Leukotriene D4; D017999:Leukotriene E4