Severe hypodiploidy with karyotype instability in a case of acute myeloid leukemia.
We present a case of acute myeloid leukemia (AML) in an elderly male. A severe hypodiploid karyotype (chromosome range 29-39) was detected with a large amount of cell-to-cell variation, suggesting that the leukemic cells are primarily characterized by chromosomal loss due to karyotypic instability. Severe hypodiploidy is a rare finding in AML but previous similar cases indicate that it confers a very poor prognosis.
Betts
D R
DR
ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, England.
Baugh
O H
OH
Gibbons
B
B
D000208:Acute Disease; D000368:Aged; D000782:Aneuploidy; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male