[A hypotensive analog of platelet-activating factor (PAF) in pheretima].
Experiments showed that intravenous administration of pheretima decoction elicited pronounced decrease of hypotension in rats. Pretreatment with CV6209, a specific PAF antagonist, significantly inhibited the hypotensive activity of pheretima. Furthermore, an analog of PAF was separated from the total lipids of pheretima and its content was measured to be around 90-130 ng/g.
Wannan Medical College, Wuhu.
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Cheng
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Ma
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D008297:Male; D008419:Materia Medica / Q000737:chemistry / Q000494:pharmacology*; D009835:Oligochaeta / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D008419:Materia Medica; D010972:Platelet Activating Factor