Linear pharmacokinetics of a new inotropic agent.
The dose-dependent pharmacokinetics of N,N'-dicyclopropyl-methyl-piperazine- dichlorhydrate (Ino 2628 CZ, CAS 82909-97-5), a new inotropic compound, was studied after 4 intravenous infusions in 3 subjects and 4 orally administered doses in 6 subjects. Plasma and urine levels were determined over 72 h. The results show that the pharmacokinetics of Ino 2628 CZ was dose proportional over the intravenous and oral dose range of 100 to 400 mg.
Trenque
T
T
Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire, Reims, France.
Barre
J
J
Lamiable
D
D
Tillement
J P
JP
D000284:Administration, Oral; D000328:Adult; D002316:Cardiotonic Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004563:Electrochemistry; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010879:Piperazines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D002316:Cardiotonic Agents; D010879:Piperazines; C059182:N,N'-dicyclopropylmethylpiperazine