Malignant exophthalmos associated with multiple myeloma.
We report a patient with malignant exophthalmos associated with multiple myeloma which showed no evidence of direct orbital involvement of plasma cells. This exophthalmos had similarities with Graves' ophthalmopathy, but the patient had no detectable autoimmune thyroid diseases. Plasmapheresis was effective not only for the treatment of heart and renal failure due to the myeloma kidney but also for the malignant exophthalmos. As the serum monoclonal IgG level was decreased by plasmapheresis, the improvement of proptosis, visual acuity, and hypertrophy of the extraocular muscle as measured by magnetic resonance imaging were observed. It is suggested that humoral factors removed by plasmapheresis might be involved in the pathogenesis of this nonendocrine exophthalmos.
Seya
A
A
Second Department of Internal Medicine, School of Medicine, Chiba University Hospital.
Terano
T
T
Hattori
Y
Y
Tomizuka
T
T
Morio
H
H
Kino
T
T
Hirai
A
A
Nishikawa
T
T
Tamura
Y
Y
Yoshida
S
S
D000368:Aged; D005094:Exophthalmos / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D010950:Plasma Cells / Q000473:pathology; D010956:Plasmapheresis