Relationship of blood flow to antral lesion incidence in rat gastric mucosa after hemorrhage and retransfusion.
The relationship of gastric mucosal hemodynamics, energy metabolism, and acid to antral histological lesion incidence following hemorrhage and retransfusion was investigated in rats. Decrease of mucosal blood flow and of the index of mucosal oxygen saturation (ISO2) during hemorrhage were slightly greater in the corpus than in the antrum. ATP content and redox ratio in the corpus were decreased by shock; however, these hardly changed in the antrum. The index of tissue hemoglobin concentration (IHb) recovered to above the prehemorrhage value only in the antrum after retransfusion. Histological lesion incidence in the antral mucosa was more markedly increased by acid instillation and/or retransfusion than in the corpus. From these results, it was concluded that the decrease of blood flow is related as an underlying factor to induction of ischemic damage in the antral mucosa and that intraluminal acid and/or postischemic hyperemia play a causative role in the development of histologic lesions in the antral mucosa during shock and retransfusion in the rat stomach.
First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
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Hachiya
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Bessho
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001803:Blood Transfusion; D005753:Gastric Mucosa / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000473:pathology* / Q000503:physiopathology*; D006439:Hemodynamics; D008297:Male; D009243:NAD / Q000378:metabolism; D011706:Pyloric Antrum / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow
D000227:Adenine Nucleotides; D009243:NAD