Chronic lymphoproliferative disorders: classification and diagnosis.
The chronic lymphoproliferative disorders are morphologically, immunologically and clinically heterogeneous. Common features of these processes include T, B or natural killer cell immunophenotypes and terminal deoxy-nucleotidyl transferase negativity. The B cell lymphocytic disorders include B-chronic lymphocytic leukaemia, B cell prolymphocytic leukaemia, chronic lymphocytic leukaemia-prolymphocytic leukaemia, non-Hodgkin's lymphoma (including mantle cell lymphoma) in leukaemic phase, hairy cell leukaemia and splenic lymphoma with villous lymphocytes. The T cell chronic lymphoproliferative disorders include prolymphocytic leukaemia, adult T cell leukaemia-lymphoma, large granulated lymphocyte leukaemia and Sézary syndrome. Occasionally, a lymphocytic proliferation is encountered that does not satisfy the morphological or immunophenotypical criteria for any of the above categories. These processes are best left unclassified.
Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota Hospital, MN 55455.
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D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D015463:Leukemia, Prolymphocytic / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D015461:Leukemia, Prolymphocytic, T-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000145:classification* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology; D012751:Sezary Syndrome / Q000145:classification / Q000175:diagnosis / Q000473:pathology
D014408:Biomarkers, Tumor