Reduced contractile function after balloon denudation of rat carotid arteries.
In rat carotid arteries isolated 2 weeks after balloon denudation, a significant neointima developed with little change in medial size. Associated with this neointimal hyperplasia was a marked decrease in contraction to various agents including angiotensins I and II, big endothelin-1, endothelin-1, norepinephrine, phenylephrine, and serotonin. Vasodilator responses to acetylcholine were significantly reduced. In contrast, vasodilator responses to nitroglycerin were unaffected. It is suggested that modulation of the neointimal cells to a more non-contractile phenotype may be responsible for the loss in contractile ability.
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000.
M J
MJ
Antonaccio
D
D
Normandin
P
P
Ferrer
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology*; D002404:Catheterization; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009126:Muscle Relaxation / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D005996:Nitroglycerin / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D005996:Nitroglycerin; D000109:Acetylcholine