Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in dogs.
The 13-week oral toxicity of nefiracetam (N-(2,6-dimethylphenyl)-2-(2-oxo- 1-pyrrolidinyl) acetamide, DM-9384, CAS 77191-36-7), a new cognition-enhancing agent, was investigated in Beagle dogs of both sexes. No change was observed in the 20 mg/kg group. Hypospermatogenesis and slightly increased deposition of hemosiderin in the spleen were seen in male dogs treated with 60 mg/kg or more. Dosing at 180 mg/kg induced a decrease in food consumption, increases in urinary volume and urinary protein, and renal papillary necrosis in both male and female dogs. The non-toxic dose was 20 mg/kg under these experimental conditions.
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
T
T
Sugawara
M
M
Kato
N
N
Suzuki
K
K
Akahane
S
S
Takayama
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D004435:Eating / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011619:Psychotropic Drugs / Q000633:toxicity* / Q000652:urine; D011760:Pyrrolidinones / Q000633:toxicity* / Q000652:urine; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
D011619:Psychotropic Drugs; D011760:Pyrrolidinones; C058876:nefiracetam