The active role of beta gamma in signal transduction.
Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have emerged in the past year. Recent experiments highlight the versatility of beta gamma-subunits in these regulatory pathways, but also emphasize some fundamental questions that remain.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235-9041.
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D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D008961:Models, Structural; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism
D020690:GTPase-Activating Proteins; D046911:Macromolecular Substances; D011506:Proteins; D010738:Type C Phospholipases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases