[Current scopes on tissue factor: its physiological function and relationship with coagulation diseases].
Monocytes/macrophages and endothelial cells express tissue factor (TF), an initiator for blood clotting pathway, following their activation accompanied by immune response and/or inflammation. This TF expression results in thrombin generation and fibrin formation around these cells and possibly participates in host-defense mechanism. TF expression by these cells is also a risk-factor to vascular diseases including arteriosclerosis and thrombosis. In cancer and leukemia patients elevation of their plasma TF level associated with DIC and related coagulation disorders.
Nakamura
S
S
Department of Cellular and Molecular Biology, Kyoto University.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology*; D006801:Humans; D007111:Immunity, Cellular; D013917:Thrombin / Q000378:metabolism; D013925:Thromboplastin / Q000235:genetics / Q000502:physiology*; D014652:Vascular Diseases / Q000209:etiology
D013925:Thromboplastin; D013917:Thrombin