[The ultrastructure of the parietal exocrinocytes of the glandulae propriae in the gastric mucosa in A avitaminosis].
Electron microscopic and morphometric methods were used to study the state of the parietal exocrinocytes of the proper glands of gastric mucosa in dynamics of A avitaminosis. The experiment was performed in 80 albino rats taken from mother's feeding with the initial body mass 40-50 g, divided into 2 groups. In animals of the first group A-avitaminosis was induced by feeding the animals with semisynthetic diet devoid of vitamin A. The 2nd control group was given the same semisynthetic diet but with retinol acetate (45 units a day for each animal). Ultrastructural findings showing the elevated production of hydrochloric acid at early stages of the development of A avitaminosis were obtained: hyperplasia of the internal mitochondrial membrane, dilatation of the intracrystal space and considerable enlargement of the area of secretory membranes of tubulovesicles and microvilli of the intracellular tubules. Deep deficiency of vitamin A disturbs the stability of intracellular membranes and leads to irreversible destructive alterations in the proper gastric glands by the end of the experiment. The facts obtained are of importance for both the understanding of specific nature of secretion of hydrochloric acid and for mechanisms of development of erosion and ulcers of gastric mucosa in A avitaminosis.
Gulich
M P
MP
Gnatovskaia
S I
SI
Onoprienko
E N
EN
D000818:Animals; D008854:Microscopy, Electron; D010295:Parietal Cells, Gastric / Q000648:ultrastructure*; D051381:Rats; D013997:Time Factors; D014802:Vitamin A Deficiency / Q000473:pathology*; D014886:Weaning
Ul'trastruktura parietal'nykh ékzokrinotsitov sobstvennykh zhelez slizistoĭ obolochki zheludka pri A-avitaminoze.