Amino acids and peptides. XXI. Laminin-related peptide analogs including poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis.
Laminin-related peptides, Tyr-Ile-Gly-Ser-Arg analogs, were prepared and their inhibitory effects on experimental metastasis were examined. Of the amino acids in the Tyr-Ile-Gly-Ser-Arg sequence, L-Arg was very important and Ile was not essential for the inhibitory effect. To obtain a potent inhibitor of metastasis, hybrids of Tyr-Ile-Gly-Ser-Arg-Gly and 2 types of poly(ethylene glycol) were prepared. The inhibitory effects of the hybrids were more potent than that of Tyr-Ile-Gly-Ser-Arg-Gly.
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan.
K
K
Kawasaki
T
T
Murakami
M
M
Namikawa
T
T
Mizuta
Y
Y
Iwai
Y
Y
Yamashiro
T
T
Hama
S
S
Yamamoto
T
T
Mayumi
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis* / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use*; D007797:Laminin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use*; D008546:Melanoma, Experimental / Q000517:prevention & control* / Q000556:secondary*; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000627:therapeutic use*
D000596:Amino Acids; D000970:Antineoplastic Agents; D007797:Laminin; D010455:Peptides; D011092:Polyethylene Glycols