Use of antibiotic-PMMA beads in the ischemic foot.
Thirty-six patients with 44 ischemic foot infections were managed with antibiotic-polymethylmethacrylate (PMMA) beads. Most of these patients received gentamicin-impregnated PMMA beads but tobramycin and vancomycin-impregnated PMMA beads were used on three patients. Angiopathy occurred in 35 patients secondary to diabetes and secondary to renal disease in 2; 1 patient had both diabetes and renal disease. The most common bacteria was Staphylococcus aureus (82%), although other organisms and multiple bacteria were present. In spite of the variability of the bacteria, PMMA beads were helpful in managing foot infections in this difficult patient population.
Div of Orthopedic Surgery, University of Texas Medical Branch, Galveston 77555-0792.
J H
JH
Calhoun
K
K
Klemm
D M
DM
Anger
J T
JT
Mader
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005528:Foot / Q000098:blood supply*; D005534:Foot Diseases / Q000188:drug therapy* / Q000382:microbiology; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000209:etiology; D007511:Ischemia / Q000150:complications*; D008297:Male; D008768:Methylmethacrylates / Q000627:therapeutic use*; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D004343:Drug Implants; D005839:Gentamicins; D008768:Methylmethacrylates; C030159:gentamicin-polymethylmethacrylate bead