[The HLA-B5 immunogenetic marker in Behçet's disease].
Twenty-three patients with Behçet's disease (BD) meeting the criteria of the international group for classification and diagnosis of BD (17 men and 6 women) were typed for HLA antigens class 1. The patients group was multinational, of them 19 were Caucasoids and 4 Mongoloids. It was shown that HLA B5 in Caucasoids occurred more frequently vs normal controls (73.7% and 15.5%, respectively). Under the correction of the antigens number up to 21, the differences continued to be statistically high. Characteristic for B5 antigen was a high relative risk and close association with the disease. In antigen group B5 + B35 the relative risk and association power grew still higher. The B5 positive group statistically more frequently had superficial thrombophlebitis and less frequently gastrointestinal involvement. It is concluded that class 1 HLA antigens, B5 in particular, are closely associated with BD in CIS countries.
Alekberova
Z S
ZS
Madanat
V Ia
VIa
Polianskaia
I S
IS
Prokaeva
T B
TB
D000328:Adult; D001528:Behcet Syndrome / Q000208:ethnology / Q000235:genetics / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D017517:Commonwealth of Independent States; D004198:Disease Susceptibility; D005260:Female; D005819:Genetic Markers; D015234:HLA-A Antigens / Q000097:blood; D015235:HLA-B Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D010641:Phenotype; D044465:White People
D015415:Biomarkers; D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens; C035270:HLA-B5 antigen
HLA-B5-immunogeneticheskiĭ marker bolezni Bekcheta.