[Effect of total alkaloids of kudouzi (Sophora alopecuroides L.) on tolerance to anoxia in mice].
To several anoxia mice models, total alkaloids of Kudouzi (TASa) can prolong their tolerance time (ip < 1/10, 1/5LD50/kg, P < 0.05-0.01). In the experiment of myocardial ischemia induced by pituitrin, TASa decreased significantly the ST change in ECG (P < 0.05). The acute LD50 of TASa by ip was found to be 130.66 +/- 22.64 mg/kg for mice.
Dept. of Pharmacy, Inner Mongolia Medical College, Inner Mongolia Autonomous Region, Huhehot.
T F
TF
Yu
J
J
Wang
L
L
Bian
H Z
HZ
Zhu
D000470:Alkaloids / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D000860:Hypoxia / Q000517:prevention & control*; D008297:Male; D051379:Mice; D017202:Myocardial Ischemia / Q000517:prevention & control*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; D004365:Drugs, Chinese Herbal