[The concept of stress and the role of hypothalamic and extra-hypothalamic corticotropin-releasing factor (CRF) in the integration of the neuroendocrine and immune responses. Clinical and experimental aspects].
Several evidences suggest the existence of a bidirectional link between the immune and neuroendocrine systems. This relationship explains how a "non cognitive" stimulus (as antigen) can activate the neuroendocrine axis through the inflammatory substances (cytokines) in the same manner as a stress response. A disregulation of this response can determine the basis for a pathological situation. The key-peptide of the stress response is hypothalamic CRF, though also extra-hypothalamic sources, such as the cells of the immune system, are present and could play an important role in the peripheral regulation of stress response.
Istituto di I Clinica Medica, Università degli Studi di Roma La Sapienza, Roma.
P L
PL
Puri
A
A
Palma
A
A
Fabbri
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008954:Models, Biological; D015213:Neuroimmunomodulation / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*
D016207:Cytokines; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone
Concetto di stress e ruolo del corticotropin-releasing factor (CRF) ipotalamico ed extraipotalamico nell'integrazione della risposta neuroendocrina ed immunitaria. Aspetti clinici e sperimentali.