Single photon emission computed tomography with [99Tc]-HM-PAO and [123I]-IBZM in Alzheimer's disease and dementia of frontal type: preliminary results.
Dementia of frontal type (DFT) is a fairly common degenerative disease distinct from Alzheimer's disease (AD), whose reportedly distinctive instrumental feature is frontal lobe hypoperfusion on SPECT. We evaluated the cortical dopaminergic system in 6 AD, 5 DFT, and 6 control subjects with SPECT and both [99Tc]-HM-PAO, a perfusion tracer, and [123I]-IBZM, a D2 postsynaptic ligand. Both in AD and DFT patients, [99Tc]-HM-PAO SPECT showed a relative frontal hypoperfusion. On the contrary, [123I]-IBZM SPECT showed significantly reduced ligand uptake in superior frontal regions of DFT (0.89 +/- 0.08 relative to control subjects) as compared to AD patients (0.97 +/- 0.02; difference of means: 0.08, 95% Confidence Interval 0.004 to 0.156; p = 0.041). Results suggest more marked involvement of the frontal cortical dopaminergic system in DFT than in AD patients.
Frisoni
G B
GB
Alzheimer's Disease Care Unit, Ist. S. Cuore-FBF, Brescia, Italy.
Pizzolato
G
G
Bianchetti
A
A
Chierichetti
F
F
Ferlin
G
G
Battistin
L
L
Trabucchi
M
M
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000503:physiopathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging; D003704:Dementia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011954:Receptors, Dopamine; D017556:Technetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon
D011954:Receptors, Dopamine; D017556:Technetium Compounds