[Evaluation of DNA content in glandular expansion and adenocarcinoma of gastric mucosa].
Gastric mucosa biopsies from 61 patients with gastric adenocarcinoma and glandular expansion of different nature were used to study DNA content with photo-cytometry technique. It was found that the number of diploid and near diploid cells in simple glandular expansion and dysplastic glandular expansion of gastric mucosa gradually decreased and finally disappeared in gastric adenocarcinoma. The proliferating diploid cells increased with the seriousness of the dysplastic hyperplasia and the DNA ploidy patterns illustrated in histogram became widened with a right shift of the highest peak with a significant increase of the DNA content, moreover, aneuploid cells could also be found. The DNA content of cell nucleus and the ploidy histogram of the grade III dysplastic glandular expansion approached those of tubular adenocarcinoma.
150 Hospital, People's Liberation Army.
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YK
Wang
D000230:Adenocarcinoma / Q000235:genetics*; D000782:Aneuploidy; D004247:DNA / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005753:Gastric Mucosa / Q000737:chemistry*; D006801:Humans; D011230:Precancerous Conditions / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm; D004247:DNA