An investigation of the local anaesthetic effects of pethidine in volunteers.
We have investigated the local anaesthetic effects of 0.1% and 0.2% pethidine compared with 0.5% prilocaine using an intravenous regional anaesthetic technique, in a randomised, double-blind study in volunteers. Both pethidine and prilocaine produced a sensory and motor blockade, although the latter had a more profound effect, with a faster onset and slower recovery. Pethidine in low concentration clearly has a local anaesthetic action on peripheral nerves.
Oldroyd
G J
GJ
Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff.
Tham
E J
EJ
Power
I
I
D000328:Adult; D000765:Anesthesia, Conduction; D000771:Anesthesia, Intravenous; D000772:Anesthesia, Local; D000779:Anesthetics, Local; D003080:Cold Temperature; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008614:Meperidine; D009046:Motor Neurons / Q000187:drug effects; D011318:Prilocaine; D012677:Sensation / Q000187:drug effects; D013997:Time Factors; D014110:Touch / Q000187:drug effects
D000779:Anesthetics, Local; D011318:Prilocaine; D008614:Meperidine