The metabolism of ethosuximide.
The metabolism of the antiepileptic drug ethosuximide (3-ethyl-3-methylpyrollidine-2,5-dione) (I) in animals and humans is reviewed. Chiral aspects of the metabolism of ethosuximide are discussed. Clarification of the precise nature of the hydroxymetabolites of ethosuximide is presented.
School of Pharmacy, Queen's University of Belfast, UK.
J S
JS
Millership
J
J
Mifsud
P S
PS
Collier
D000818:Animals; D005013:Ethosuximide / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans
D005013:Ethosuximide