[Microrheology of marrow promyelocytes from patients suffering from acute myeloblastic leukemia type 3].
Viscosity values of marrow cells from patients suffering from acute promyelocytic leukemia (acute myeloid leukemia of type 3) have been determined before and during a treatment with all-trans retinoïc acid (active metabolite of the vitamin A, inducing cell differentiation and maturation). Evaluated from aspiration tests into a glass micropipette, the marrow cell viscosity has been compared to that of normal neutrophils. Results seem to point out that the induced hyperleucocytosis is favoured by both a low standard deviation of pathological cell viscosity and a cell viscosity value close to that of normal neutrophils. The systematic study of cell viscosity could therefore help the clinicians to individualize the treatment.
Unité de Biorhéologie, Université Paris VI.
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Geiger
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Dombret
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Bucherer
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Lacombe
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JC
Lelièvre
D006098:Granulocytes / Q000502:physiology*; D018056:Hemorheology; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology / Q000503:physiopathology*; D008846:Micromanipulation; D013237:Stereoisomerism; D014212:Tretinoin / Q000627:therapeutic use
D014212:Tretinoin
Microrhéologie des promyelocytes médullaires de patients atteints de leucémie aiguë myéloblastique de type 3.