Increased blood [TAME]-esterase activity during exercise-induced asthma.
Twelve non-atopic asthmatic children who were reported to be suffering from exercise-induced asthma (E-IA), and eight non-asthmatic children, were studied in an attempt to discern possible associations between N-alpha-tosyl-L-arginine methyl ester [TAME]-esterase activity and E-IA, and the late asthmatic responses. Lung function tests and clinical examinations were performed at rest, and immediately and four hours after cycling for 6 min. Concomitant blood investigations revealed a consistent elevation in the asthmatics of [TAME]-esterase activity and peripheral blood eosinophil levels, immediately following exercise. Our findings suggest that E-IA is associated with a certain threshold of [TAME]-esterase activity as measured by a simple and a rapid colorimetric method.
SSR Centre for Medical Studies and Research, School of Science, University of Mauritius, Moka.
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D000293:Adolescent; D001250:Asthma, Exercise-Induced / Q000201:enzymology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood*
D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase