[Direct effect of streptococcal preparation 722 (Sapylin) on squamous cell carcinoma (Tca8113) cells of human tongue in vitro and in vivo].
When the Tca8113 cells contacted with streptococcal preparation 722 in 0.2-1.0 KE/ml concentration directly and continuously in Vitro, the ability of colony-forming of the cells was lost. Using time lapse microcinematographic study it was confirmed that this agent has a direct cytostatic activity on Tca8113 cells, but it was also confirmed that this activity was reversible after 4 days. Effect of 722 on transplantable tumor of Tca8113 cells in nude mice with different routes (ip, id, it) had no-response. The results suggest that the effect of 722 preparation on antitumor in Vivo must have a complete immune function in the host.
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School of Stomatology, Shanghai 2nd Medical University.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology; D001688:Biological Products / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013291:Streptococcus; D014062:Tongue Neoplasms / Q000473:pathology* / Q000628:therapy; D014407:Tumor Cells, Cultured; D014410:Tumor Stem Cell Assay
D000276:Adjuvants, Immunologic; D001426:Bacterial Proteins; D001688:Biological Products; C569879:streptococcal preparation 722