Gastric and intestinal absorption of monofluorophosphate and fluoride in the rat.
This paper reports data indicating that, in the rat, sodium monofluorophosphate (MFP, CAS 10163-15-2) is absorbed without hydrolysis through the stomach. This phenomenon and the fact that MFP binds to plasma globulins produce a prompt increase in protein-bound MFP concentration, significantly greater than the increase in plasma ultrafilterable fluoride. Intestinal absorption of MFP was investigated with the isolated duodenal loop in situ. The drug was hydrolyzed to fluoride at the intestinal lumen with a rate of approx. 3 times greater than that for fluoride absorption. After filling the duodenal loop with a MFP solution, ultrafiltrable fluoride accounts for the increase in plasma fluoride concentration, with no evidence of protein-bound MFP. This report also includes analytical techniques for the measurement of MFP in test solutions and in plasma.
Laboratorio de Biologia Osea, Facultad de Medicina, Rosario, Argentina.
A
A
Rigalli
M A
MA
Cabrerizo
A D
AD
Beinlich
R C
RC
Puche
D000818:Animals; D001798:Blood Proteins / Q000737:chemistry; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005459:Fluorides / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism*; D006868:Hydrolysis; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology*; D008954:Models, Biological; D010710:Phosphates / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry; D051381:Rats
D001798:Blood Proteins; D010710:Phosphates; D011506:Proteins; C012980:fluorophosphate; D005459:Fluorides