[Transient hypertrophic cardiomyopathy as a consequence of mediastinal radiotherapy in a 3-year-old child].
The authors present the case of a three and a half years old child with large mediastinal tumor who developed transient hypertrophic cardiomyopathy two weeks following the termination of mediastinal radiotherapy. He had already received the second weekly dose of EVAIA treatment (ifosfamide, vincristine, etoposide, adriamycin) when symptoms manifested themselves. In spite of continuation of chemotherapeutic treatment (without adriamycin) symptoms disappeared and eight months later normal septal thickness, and normal ventricular function were detected. Chemotherapy may have facilitated the effect of irradiation but the latter is considered the major causative factor.
Debreceni Orvostudományi Egyetem, Gyermekklinika.
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Mogyorósy
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Kovács
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Sulyok
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000209:etiology*; D002675:Child, Preschool; D002985:Clinical Protocols; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects
D003037:Cobalt Radioisotopes
Mediastinalis sugárterápia következtében kialakult átmeneti hypertrophiás cardiomyopathia 3 éves gyermeknél.