[Hypotension, hypoglycemia and hypouricemia recorded after repeated administration of aqueous leaf extract of Olea europaea L].
This study is concerned by the determination of the toxicity of an Olea europaea L.aqueous leaf extract after repeated administrations. Female and male rats were given 37.5, 75, 150, 300, 600 and 1200 mg/Kg/24h of the extract for 60 days. The results show that the drug studied induces an increase of weight growth, an hypotension, an hypoglycaemia and an hypouricaemia in treated animals.
Département de Pharmacologie et de Toxicologie, Société des Industries Pharmaceutiques de Tunisie, Fondouk Choucha, Radès.
B
B
Fehri
J M
JM
Aiache
A
A
Memmi
S
S
Korbi
M T
MT
Yacoubi
S
S
Mrad
J L
JL
Lamaison
D000818:Animals; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced* / Q000473:pathology; D007022:Hypotension / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014527:Uric Acid / Q000097:blood*
D010936:Plant Extracts; D014527:Uric Acid
Hypotension, hypoglycémie et hypouricémie enregistrées à la suite d'une administration réitérée d'un extrait aqueux de feuilles d'Olea europaea L.