Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: role of TGF beta in osteophyte formation?
Osteoarthritis is characterized by focal cartilage destruction and marked formation of osteophytes. We have investigated the possible relationship between site specific occurrence of cartilage damage and osteophytes in the collagenase induced murine osteoarthritis model. The degree of instability of the joint correlated with the amount of cartilage loss. Moreover, cartilage damage in the medial tibial plateau correlated only strongly with the osteophyte at the medial plateau, whereas a similar, site directed trend was noted for lateral damage and lateral osteophytes. A separate study with intraarticular injection of TGF beta 1 in normal murine knee joints revealed that this factor can induce osteophytes at characteristic sites, suggesting a role of endogenous TGF beta in this phenomenon.
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
W B
WB
van den Berg
G J
GJ
van Osch
P M
PM
van der Kraan
H M
HM
van Beuningen
D000818:Animals; D002356:Cartilage / Q000473:pathology*; D017364:Collagenases / Q000008:administration & dosage; D004195:Disease Models, Animal; D005260:Female; D006614:Hindlimb / Q000473:pathology; D007270:Injections, Intra-Articular; D008023:Ligaments, Articular / Q000293:injuries; D008233:Lymphotoxin-alpha / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010003:Osteoarthritis / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D013045:Species Specificity
D008233:Lymphotoxin-alpha; D017364:Collagenases