[Measurement of the concentrations of PGF2 alpha and PG12 in the cochlear lateral wall of guinea pigs following intravenous injection of ethacrynic acid].
The concentrations of prostaglandin F2 alpha(PGF2 alpha) and prostacyclin (PGI2) in the cochlear lateral wall of guinea pigs following intravenous injection of ethacrynic acid (EA) were measured with radioimmunoassay. After injection of EA (60mg/kg) 30, 60, 120 minutes, the concentrations of PGF2 alpha and PGI2 in the cochlear lateral wall of three experimental groups were not significantly different from control ones respectively. The results suggested that there was no remarkable relationship between PGF2 alpha PGI2 and the changes of the microcirculation of cochlear lateral wall caused by EA.
Liu
B
B
Union Hospital, Tongji Medical University, Wuhan.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D003051:Cochlea / Q000737:chemistry* / Q000187:drug effects; D015237:Dinoprost / Q000032:analysis*; D011464:Epoprostenol / Q000032:analysis*; D004976:Ethacrynic Acid / Q000633:toxicity*; D006168:Guinea Pigs; D007275:Injections, Intravenous; D011897:Random Allocation
D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D011464:Epoprostenol; D004976:Ethacrynic Acid