L-arginine improves transmission of perfusion pressure to the renal interstitium in Dahl salt-sensitive rats.
L-Arginine normalizes pressure natriuresis in Dahl salt-sensitive (DS) rats. To determine the role of renal interstitial hydrostatic pressure (RIHP) in this phenomenon, we measured RIHP determined by servo-null during acute changes in renal perfusion pressure in anesthetized DS rats receiving L-arginine (300 mg.kg-1.day-1 ip) or vehicle for 3 wk. Dahl salt-resistant (DR) rats were controls. As observed previously, the slope of the pressure-natriuresis relationship was greater (P < 0.05) in L-arginine-treated DS rats than vehicle DS rats and not different from DR rats. The slope of the relationship between renal perfusion pressure and RIHP was greater (P < 0.05) in DR rats than vehicle DS rats. In L-arginine-treated DS rats the slope of this relationship was greater (P < 0.05) than that in vehicle DS rats and not different from DR rats. Removal of the renal capsule blunted the pressure-natriuresis relationship in L-arginine-treated DS rats but had no effect in vehicle DS rats. Thus L-arginine improves transmission of perfusion pressure into the renal interstitium in DS rats and may contribute to the improved pressure-natriuresis response.
Department of Medicine, University of Mississippi Medical Center, Jackson 39216-4505.
A R
AR
Patel
J P
JP
Granger
K A
KA
Kirchner
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics; D006874:Hydrostatic Pressure; D007668:Kidney / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D001120:Arginine