Effect of electric charge on the adhesion of human blood platelets.
The paper presents the results of research into the effect of the size and depth of the implanted electric charge on the adhesion of human blood platelets. The experiments were carried out on polyethylene terephthalate PET foil of 36 microns thickness. The electret formation process was carried out in an electron-beam device. The electrization conditions were such that electrets with the excess electric charge accumulated at various depths were obtained. The selection of conditions was verified by investigating the space charge distribution with the use of the virtual electrode method. The microscopic observation of non-electrified foils and electrets as well as the quantitative examination of the adhesion of human blood platelets has explicitly confirmed the positive influence of the electret effect on the thrombogenesis of PET foil. This made it possible to define the optimum electrization conditions. The research has additionally indicated that the relationship between the amount of adherent blood platelets and the size of the electric charge is not a simple relation of the kind: the larger negative charge, the more thrombogenic material. The decisive and positive effect of the space charge has been confirmed by analysing the effectiveness of the surface and space charge.
Lowkis
B
B
Institute of Electrical Engineering Fundamentals, Technical University of Wrocław.
Szymonowicz
M
M
D001672:Biocompatible Materials; D001792:Blood Platelets / Q000166:cytology; D004560:Electricity; D006801:Humans; D008853:Microscopy; D010973:Platelet Adhesiveness / Q000502:physiology*; D011093:Polyethylene Terephthalates; D013499:Surface Properties
D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates