Chronic allograft rejection: an update.
The etiology of chronic rejection is most probably multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalized arteriosclerosis affecting all first and second order intramural arteries. A hypothesis is presented that low-grade damage to endothelium induces the secretion of growth factors which, in turn, are responsible for smooth muscle cell replication and their influx into intima.
Transplantation Laboratory, University of Helsinki, Finland.
P
P
Häyry
D006084:Graft Rejection / Q000503:physiopathology*; D006801:Humans; D014184:Transplantation, Homologous