Hemodynamic and nonhemodynamic mechanisms of experimental pulmonary edema in rats and the effects of anisodamine and tetramethylpyrazine--estimation of blood gas analysis, RBC superoxide dismutase and prostaglandin E2 in plasma and bronchoalveolar lavage (Part 3).
Anisodamine (ADM, 654-2, 30 mg/kg) and tetramethylpyrazine (TMP, 120 mg/kg) have shown an apparent preventive effect on pulmonary edema (PE). In this study, the nonhemodynamic mechanism was studied: The dynamic changes of PaO2, O2Sat, PaCO2, and blood pH were measured, and RBC superoxide dismutase (SOD) and plasma and bronchoalveolar lavage (BAL) PGE2 levels were estimated. It was concluded that ADM and TMP exerted inhibitory effects on the hypoxic state. The ability of ADM and TMP to adjust RBC SOD and PGE2 levels may be one of the preventive mechanisms of the drugs.
Dai
S
S
Institute of Basic Medical Sciences, CAMS, Beijing.
Cheng
J
J
Sun
R
R
Duan
J
J
Yuan
Q
Q
Sun
Y
Y
Yan
Y
Y
Xue
Q
Q
D000818:Animals; D001784:Blood Gas Analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D015232:Dinoprostone / Q000378:metabolism*; D004837:Epinephrine; D008297:Male; D011654:Pulmonary Edema / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D011719:Pyrazines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D011719:Pyrazines; D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D013482:Superoxide Dismutase; D015232:Dinoprostone; C017953:tetramethylpyrazine; D004837:Epinephrine