[The effect of heroin on red cell immunoadherence function of human body].
Red cell immunocompetence was studied in 38 cases of heroin addicts by measuring the rate of red blood cell C3b receptor rosette (RBC-C3bRR), and red blood cell immune complex rosette (RBC-ICR) the concentration of complement C3 and the content of circulating immune complex (CIC). The results showed that the rate of RBC-C3bRR and RBC-ICR and C3 concentration in the heroin addicts decreased significantly, while their CIC content increased significantly as compared with those of the controls. It was also found that the duration of drug taking was related with the changes of the rate of RBC-C3bRR and RBC-ICR, C3 concentration and CIC content. It is suggested that red cell immunoadherence function in heroin addicts decreases significantly as to influence the clearance of CIC.
Department of Endocrinology, First Affiliated Hospital of Kunming Medical College.
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Xu
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Song
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Li
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000276:immunology; D003179:Complement C3b / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006556:Heroin Dependence / Q000276:immunology*; D006801:Humans; D008297:Male; D017463:Receptors, Complement 3b / Q000276:immunology*; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D017463:Receptors, Complement 3b; D003179:Complement C3b