Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion.
Wistar albino rats were intravenously injected with 1 ml of an oxyphoretic emulsion of perfluorobutyl-furane and killed 3, 7 or 30 days later. Mitochondria isolated from the liver and kidneys of treated rats showed a small decrease in the transmembrane electrical potential and a substantial depression of the rates of both ATP synthesis and ADP-stimulated respiration. These alterations in mitochondrial oxidative phosphorylation appear to be induced by perfluorocarbon and/or tensioactive molecules interacting with hydrophobic cell structures.
Branca
D
D
Department of Biological Chemistry, University of Padova, Italy.
Chiarelli
S M
SM
Vincenti
E
E
Tortorella
C
C
Scutari
G
G
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D005466:Fluorocarbons / Q000633:toxicity*; D005663:Furans / Q000633:toxicity; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008297:Male; D008564:Membrane Potentials; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D005466:Fluorocarbons; D005663:Furans; D000255:Adenosine Triphosphate