Derivatives of 2-mercaptobenzenesulphonamide. XII. Synthesis and some pharmacological properties of 2-(2-mercaptobenzenesulphonyl)imidazoline.
Synthesis of 2-[2 (alkylaminoalkylthio)-4-R1-5-R2-benzenesulphonamide]-5-R3-im idazoline [IV-IX], their hydrochlorides [IVa-IXa], as well needful substrates [IIc, III] are described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of compound IVa-IXa are presented. Some structure-activity relationship is also discussed.
Brzozowski
Z
Z
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
Sławiński
J
J
Oledzka
K
K
Kosmala
M
M
Lewandowski
K
K
Filczewski
M
M
Miłobedzka
J
J
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D008970:Molecular Weight; D051381:Rats; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D013449:Sulfonamides