Detoxification of citrinin and ochratoxin A by hydrogen peroxide.
The effects of hydrogen peroxide on citrinin and ochratoxin A toxicity were examined using HeLa cells. The citrinin was completely detoxified by prior incubation with 0.05% hydrogen peroxide for 30 min at room temperature, and the toxic compound(s) that resulted from heating citrinin at 100 degrees C were also detoxified upon reheating it with hydrogen peroxide. On the other hand, ochratoxin A was not detoxified by hydrogen peroxide at room temperature, but its toxicity was reduced by heating ochratoxin A with hydrogen peroxide under alkaline conditions.
Fouler
S G
SG
Kyoto University, Research Institute for Food Science, Japan.
Trivedi
A B
AB
Kitabatake
N
N
D002470:Cell Survival / Q000187:drug effects; D002953:Citrinin / Q000633:toxicity*; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D009793:Ochratoxins / Q000494:pharmacology / Q000633:toxicity*
D009793:Ochratoxins; C025589:ochratoxin A; D002953:Citrinin; D006861:Hydrogen Peroxide