Virus-associated haemophagocytic syndrome: further evidence for a T-cell mediated disorder.
A 16-year-old youth with life-threatening virus-associated haemophagocytic syndrome (VAHS) responded remarkably to treatment with cyclosporin A during two periods of active disease, the second of which was due to noncompliance with treatment. Our clinical observations support the hypothesis that VAHS is cytokine driven as a result of an aberrant T-cell response to infection.
Watson
H G
HG
Department of Haematology, Royal Infirmary of Edinburgh.
Goulden
N J
NJ
Manson
L M
LM
McDermid
G
G
Gray
J A
JA
Parker
A C
AC
D000293:Adolescent; D016572:Cyclosporine / Q000627:therapeutic use; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008297:Male; D010976:Platelet Count; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D016572:Cyclosporine