Formulation of diazepam containing rectal suppositories and experiences of their biopharmaceutical study.
Methodology and the results of the in vitro membrane diffusion and in vivo bioavailability studies are presented. The results confirm a correlation between in vitro and in vivo findings. Hydrophilic macrogol-mixture with great molecular mass can be recommended as the optimal vehicle for formulation of diazepam suppositories.
Regdon
G
G
Albert Szent-Györgyi Medical University, Department of Pharmaceutical Technology, Szeged, Hungary.
Bácskay
I
I
Kata
M
M
Selmeczi
B
B
Szikszay
M
M
Sánta
A
A
Bálint
G S
GS
D000818:Animals; D001702:Biopharmaceutics; D003505:Cyclodextrins; D003975:Diazepam / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004339:Drug Compounding; D005079:Excipients; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013488:Suppositories; D013535:Suspensions; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D005079:Excipients; D013488:Suppositories; D013535:Suspensions; D047392:beta-Cyclodextrins; D011092:Polyethylene Glycols; C038119:heptakis(2,6-O-dimethyl)beta-cyclodextrin; C009314:polyethylene glycol monostearate; D003975:Diazepam