HLA-DPB1 alleles in patients with rheumatoid arthritis.
The distribution of HLA-DPB1 alleles was studied in 94 adult Caucasian RA patients (65 = seropositive, 29 = seronegative) and 40 normal controls. The DPB1 alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of the DPB1*0402 allele was higher in seropositive RA patients and DPB1*0201 was higher in seronegative RA patients. These differences were not significant, however. It is likely that DPB1 alleles do not play an important role in susceptibility to RA.
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Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Sastry
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Buchanan
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D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology*; D006682:HLA-DP Antigens / Q000032:analysis* / Q000235:genetics*; D059868:HLA-DP beta-Chains; D015798:HLA-DR1 Antigen / Q000032:analysis; D015804:HLA-DR4 Antigen / Q000032:analysis; D006801:Humans; D012016:Reference Values
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen