Hyperthermic injury of oligodendrocyte precursor cells: implications for dysmyelination disorders.
Although 6 h of exposure to 41 degrees C did not affect the viability of oligodendrocyte precursors in culture, a 2-h exposure to 42 degrees C caused them to die. In contrast, astrocytes could tolerate 42 degrees C for at least 6 h. There was an increase in lipid peroxidation following the 42 degrees C insult, particularly in the oligodendrocyte precursors. These findings may be of relevance in understanding certain dysmyelination disorders in humans.
Department of Anatomy, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
B H
BH
Juurlink
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Husain
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000166:cytology* / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism; D003711:Demyelinating Diseases / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006358:Hot Temperature; D006801:Humans; D015227:Lipid Peroxidation; D009836:Oligodendroglia / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D013997:Time Factors
D005904:Glial Fibrillary Acidic Protein