Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line.
Various alkyl ether lipids were synthesized and their effects on the proliferation of human lung carcinoma cells were examined. The proliferation of Lu-65, a giant cell carcinoma cell line, was significantly decreased with 1 microgram/ml (3-tetradecyloxy-2-methoxy) propyl-2-trimethylammonioethyl phosphate, while the proliferation of Lu-99, another giant cell carcinoma cell line, was unaffected even by treatment with 5 micrograms/ml of the alkyl lysophosphocholine. Adenocarcinoma PC-9 and small cell carcinoma H-69 cells were also fairly resistant to the alkyl ether lipid. Among the alkyl ether lipids tested, 3-nonadecyloxy-2-methoxypropyl 2-trimethylammonioethyl phosphate was the most effective in inhibiting the growth of Lu-65 cells. However, the pyridinioethyl derivative had higher selectivity for the growth of Lu-65 cells than the choline derivative. The sensitivity of Lu-65 cells to the alkyl lysophospholipids was similar to that of human myeloid leukemia cells including HL-60. However, the sensitivities of Lu-65 cells to the other types of alkyl ether lipids were much lower than those of HL-60 cells. These results indicate that Lu-65 cells are selectively sensitive to alkyl lysophospholipids.
Goto
I
I
Research Institute, Saitama Cancer Center, Japan.
Hozumi
M
M
Honma
Y
Y
D000230:Adenocarcinoma; D000970:Antineoplastic Agents / Q000633:toxicity*; D018286:Carcinoma, Giant Cell; D018288:Carcinoma, Small Cell; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms; D008246:Lysophospholipids / Q000633:toxicity*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008246:Lysophospholipids