Lectin effects on HIV-1 infectivity.
Lectins with specificity for terminal mannose residues and anti-mannan antibodies are assumed to neutralize HIV-1 by binding to the viral glycoproteins. In this report we demonstrate that one such agents, the lectin from Galanthus nivalis (GNA), blocks infection also at the target cell level.
Department of Veterinary Virology, Biomedical Center, Uppsala, Sweden.
L
L
Hammar
I
I
Hirsch
A
A
Machado
J
J
De Mareuil
J
J
Baillon
J C
JC
Chermann
D002240:Carbohydrate Sequence; D002478:Cells, Cultured; D027801:Galanthus; D015726:Giant Cells / Q000382:microbiology; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D037102:Lectins / Q000494:pharmacology*; D037241:Mannose-Binding Lectins; D008969:Molecular Sequence Data; D037121:Plant Lectins; D014774:Virulence / Q000187:drug effects
D015699:HIV Envelope Protein gp120; D037102:Lectins; D037241:Mannose-Binding Lectins; D037121:Plant Lectins; C063117:snowdrop lectin