CD4+ lymphocytopenia due to common variable immunodeficiency mimicking AIDS.
There are an increasing number of published reports of patients with acquired immunodeficiency without evidence of HIV infection, who have been labelled as having "idiopathic CD4+ lymphocytopenia". The case is reported here of a young man who presented with Pneumocystis carinii pneumonia (PCP), CD4+ lymphopenia, and hypogammaglobulinaemia attributable to common variable immunodeficiency (CVID). The presentation of this condition, with many of the clinical and laboratory features of AIDS, highlights CVID as a diagnosis to be considered in the differential diagnosis of CD4+ lymphocytopenia.
Department of Haematological Medicine, King's College School of Medicine and Dentistry, London.
R S
RS
Kaczmarski
A D
AD
Webster
J
J
Moxham
F
F
Davison
S
S
Sutherland
G J
GJ
Mufti
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000209:etiology*
D007136:Immunoglobulins