[Immunogenetic methods in the prognosis of the efficacy of using a method of transfusing extracorporeally irradiated autologous blood for treating patients with rheumatoid arthritis].
HLA antigens distribution among subgroups of rheumatoid arthritis (RA) patients was compared with reference to the results achieved after the treatment with transfusion of extracorporeally irradiated autologous blood (TEIB). The treatment efficacy was found to be in general 66% and to depend on HLA phenotype, age of the patients, the RA activity. The analysis of associations of clinical significance exhibited by clinical, laboratory and immunogenetic signs made it possible to derive a formula for individual prognostic criterion capable of raising TEIB efficacy to 89%.
Zonova
E B
EB
Prokof'ev
V F
VF
Ivanova
R L
RL
Konenkov
V I
VI
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D001804:Blood Transfusion, Autologous / Q000379:methods* / Q000706:statistics & numerical data; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005112:Extracorporeal Circulation; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007125:Immunogenetics; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D014467:Ultraviolet Therapy / Q000379:methods* / Q000706:statistics & numerical data
D006680:HLA Antigens
Immunogeneticheskie metody prognoza éffektivnosti primeneniia metoda perelivaniia ékstrakorporal'nogo obluchennoĭ autologichnoĭ krovi dlia lecheniia bol'nykh revmatoidnym artritom.