An acquired Robertsonian 13;15 translocation in acute myelogenous leukemia (M5b).
A 43-year-old male developed acute myelogenous leukemia (AML, M5b) with an acquired Robertsonian 13;15 translocation. He did not achieve complete remission after sequential intensive induction chemotherapy and he died 13 months later. We reviewed 7 patients with this translocation reported in the literature. Acquired Robertsonian translocations are rare, but could represent an important event in the tumorigenesis of hematologic malignancies.
Ino
T
T
Department of Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Okamoto
M
M
Tsuzuki
M
M
Kamino
I
I
Hirano
M
M
D000328:Adult; D002882:Chromosomes, Human, Pair 13; D002884:Chromosomes, Human, Pair 15; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic