The neurotropic activity of a structural analog of ACTH(5-7).
The tripeptide glutamyl-arginyl-proline (ERP) mimicking some structural features of the N-terminal fragment of adrenocorticotropic hormone, ACTH(5-7), has been synthesized. In contrast with ACTH fragments, ERP (0.015-0.15 mg/kg; intraperitoneal injection) hindered the formation of food-reinforced task in adult albino male rats. Besides, ERP caused a rapid inhibition of the previously formed conditioned task. Similar doses of ERP changed orientative-trying reaction and emotional behavior in rats in the 'open field' test. ERP at a dose of 0.15 mg/kg administered prior to the injection of 0.5 mg/kg ACTH(1-39) prevented increases in locomotor activity normally induced by this hormone. Thus, ERP disrupts learning, impairs performance of acquired task and blocks behavioral effects of ACTH and its fragments.
Ashmarin
I P
IP
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow.
Levitskaya
N G
NG
Antonova
L V
LV
Nezavibatko
V N
VN
Alfeeva LYu
Dubinin
V A
VA
Golubovich
V P
VP
Ponomareva-Stepnaya
M A
MA
Kamensky
A A
AA
D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D008969:Molecular Sequence Data; D009043:Motor Activity / Q000187:drug effects; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D009842:Oligopeptides; C088345:glutamyl-arginyl-proline; D000324:Adrenocorticotropic Hormone