[The effect of chloxyl and praziquantel treatment on the lipid phase of the erythrocyte membrane and on the antioxidant system in opisthorchiasis patients].
The effects of chloxyl and praziquantel on the lipid phase of erythrocytic membranes and the antioxidative system were studied in 77 patients with opisthorchiasis. After chloxyl treatment, patients with chronic opisthorchiasis had significantly higher contents of dienic conjugates, malonic dialdehyde, Schiff bases; in blood plasma, alpha-tocopherol content had a tendency to decrease. Treatment with praziquantel caused an increase in the content of malonic dialdehyde only in the erythrocytic membrane. Ten-day preadministration of vitamin E in a dose of 2 mg/kg body weight reduced the pro-oxidative action of praziquantel.
V A
VA
Nalobin
V A
VA
Zhmurov
S A
SA
Nalobin
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000871:Anthelmintics / Q000627:therapeutic use*; D000975:Antioxidants; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000097:blood*; D009889:Opisthorchiasis / Q000097:blood / Q000188:drug therapy*; D011223:Praziquantel / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use; D014992:Xylenes / Q000627:therapeutic use*
D000871:Anthelmintics; D000975:Antioxidants; D008563:Membrane Lipids; D014992:Xylenes; D014810:Vitamin E; D011223:Praziquantel; C000294:hexachloro-4-xylene
Vliianie lecheniia khlorsilom i prazikvantelem na lipidnuiu fazu membrany éritrotsita i antioksidantnuiu sistemu u bol'nykh opistorkhozom.