[The blocking effect of hyperin on the inward flow of calcium ion].
Hyperin(Hyp) was shown to inhibit the positive inotropic action of calcium ion on the isolated papillary muscles and shift the dose response curve of calcium ion to the right. As a plot lg(x-1) vs -lg(B) resulted in straight lines with slopes of -0.625. On the action potentials of guinea pig myocardial cells, Hyp markedly decreased the duration of plateau of action potentials (APD20%) but did not influence the APD100%, RP, APA, OS and Vmax. In the atrium preparations of mice, Hyp significantly inhibited influx of 45Ca induced by high K+. All findings indicate that Hyp can inhibit the inward flow of calcium ion.
Department of Pharmacology, Anhui Medical University, Hefei.
Z W
ZW
Chen
C G
CG
Ma
M
M
Fang
S Y
SY
Xu
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D002122:Calcium Chloride / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D013268:Stimulation, Chemical; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D015220:Calcium Channels; C021304:hyperoside; D011794:Quercetin; D014700:Verapamil; D002122:Calcium Chloride