Bone resorption rates in children monitored by the urinary assay of collagen type I cross-linked peptides.
When bone is resorbed, cross-linking amino acids from collagen type I (pyridinolines) are excreted in the urine as small peptides. The purpose of this cross-sectional study was to measure the urinary excretion of type I collagen bone degradation products in children and to correlate the results with growth velocity on a population basis. Spot urines from 1076 children and 24 adults were analyzed. The concentrations of cross-linked N-telopeptides of collage type I were measured using a new monoclonal antibody-based microtiter-plate assay, and normalized to creatinine. Age-related changes in cross-link excretion mirrored published standard growth velocity rates for males and females. The correlation coefficient between growth rates and cross-link excretion was 0.91. These results encourage more definitive longitudinal studies where growth rates and collagen cross-link excretion are correlated on an individual-patient basis.
Department of Orthodontics, University of Washington, Seattle 98195.
A M
AM
Bollen
D R
DR
Eyre
D000293:Adolescent; D000328:Adult; D001681:Biological Assay; D001827:Body Height / Q000502:physiology; D001862:Bone Resorption / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000737:chemistry / Q000652:urine*; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D046911:Macromolecular Substances; D008297:Male; D008991:Monitoring, Physiologic; D010455:Peptides / Q000737:chemistry / Q000652:urine*
D046911:Macromolecular Substances; D010455:Peptides; D003094:Collagen; D003404:Creatinine