Preliminary interpretive susceptibility testing criteria for FK-037 with 30-microgram disks.
FK-037, a new parenteral cephalosporin, was tested against 483 organisms from clinical infections to establish preliminary susceptibility testing criteria with 30-micrograms disks. The proposed breakpoint zone diameters were > or = 17 mm (MIC correlate, < or = 8 micrograms/ml) for the susceptible category and < or = 13 mm (MIC correlate, > or = 32 micrograms/ml) for the resistant category. These interpretive guidelines produced no very major (false-susceptible) errors, 2.9% major (false-resistant) errors, and 6.2% minor errors for a total absolute agreement between methods of 90.9%.
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Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
D000150:Acinetobacter / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D016983:Enterococcus / Q000187:drug effects; D005069:Evaluation Studies as Topic; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods* / Q000706:statistics & numerical data; D001936:Moraxella catarrhalis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014974:Xanthomonas / Q000187:drug effects
C079769:cefoselis; D015296:Ceftizoxime