In vitro evaluation of cefdinir (FK482), a new oral cephalosporin with enhanced antistaphylococcal activity and beta-lactamase stability.
Cefdinir (FK482), a new oral cephalosporin with enhanced beta-lactamase stability, was tested by microbroth dilution against respiratory, urogenital, and skin and skin-structure bacterial pathogens. Included were beta-lactamase (beta LAC)-producing and -nonproducing isolates. Activity was compared with that of other orally administered beta-lactams. Cefdinir minimum inhibitory concentrations for 90% of isolates MIC90s (microgram/ml) were < or = 0.5 versus beta LAC+/oxacillin-susceptible Staphylococcus, aureus, S. epidermidis, and S. saprophyticus; < or = 0.06 versus Streptococcus groups A and B, and Neisseria gonorrhoeae beta LAC+; 0.125 versus S. pneumoniae penicillin-susceptible and Proteus mirabilis beta LAC+; 0.25 versus beta LAC+ versus strains of Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, and K. oxytoca; 0.5 versus Haemophilus influenzae beta LAC-; 1 versus H. influenzae beta LAC+; 4 versus Legionella pneumophila beta LAC+; and 8 versus Enterococcus faecalis beta LAC-strains. Cefdinir was equally effective against both standard and high inocula of S. aureus strains producing A, B, C, or D beta LAC types. MICs were also generated versus quality-control reference strains.
Cohen
M A
MA
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Infectious Disease, Ann Arbor, Michigan.
Joannides
E T
ET
Roland
G E
GE
Meservey
M A
MA
Huband
M D
MD
Shapiro
M A
MA
Sesnie
J C
JC
Heifetz
C L
CL
D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D004795:Enzyme Stability; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D013291:Streptococcus / Q000187:drug effects; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D000077525:Cefdinir; D001618:beta-Lactamases