Effect of bombesin on core temperature in rats: studies involving radiotelemetry.
The effect of centrally administered bombesin on core temperature was investigated in rats which had been chronically fitted with a cannula in the third cerebral ventricle and with an intraperitoneal temperature-monitoring radiotransmitter. Intracerebroventricularly administered bombesin (0.01, 0.1 or 1 microgram) resulted in hypothermia, the duration and depth of the effect being a function of the dose. The use of telemetry minimized experimental interventions in this study; the results demonstrate that the hypothermic response to bombesin is not dependent upon exposure to a low ambient temperature, food restriction or insulin treatment as suggested by previous studies involving measurement of core temperature by a rectal probe.
Division of Biomedical Sciences, King's College, London, UK.
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RA
Persaud
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CW
Coen
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D051381:Rats; D017208:Rats, Wistar; D013686:Telemetry / Q000379:methods
D001839:Bombesin