[The activity of superoxide dismutase and its isoenzymes in the immunocompetent cells of the peripheral blood in systemic lupus erythematosus and rheumatoid arthritis].
General activity of superoxide dismutase (SOD) and its isoenzymic spectrum in lymphocytes and neutrophils were studied in the peripheral blood from 63 SLP and 85 RA patients. A significant decline in SOD activity and qualitative shifts in SOD isoenzymic spectrum were found in both cell groups. The differences were specific for lymphocytes and neutrophils. SOD isoenzymic aberrations proved significant in minimal activity of SLP and RA and go in the same direction in both the diseases. General SOD activity and its isoenzymic composition can serve sensitive indications of immunocompetent cell function both in SLP and RA and of the need in antioxidants inclusion into combined treatment of both the diseases.
G P
GP
Matveĭkov
E S
ES
Kaliia
V I
VI
Levin
N M
NM
San'ko
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D001402:B-Lymphocytes / Q000201:enzymology*; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood*; D013601:T-Lymphocytes / Q000201:enzymology*
D007527:Isoenzymes; D013482:Superoxide Dismutase
Aktivnost' superoksiddismutazy i ee izofermentov v immunokompetentnykh kletkakh perifericheskoĭ krovi pri sistemnoĭ krasnoĭ volchanke i revmatoidnom artrite.