An acquired Robertsonian 13;15 translocation in acute myelogenous leukemia (M5b).
A 43-year-old male developed acute myelogenous leukemia (AML, M5b) with an acquired Robertsonian 13;15 translocation. He did not achieve complete remission after sequential intensive induction chemotherapy and he died 13 months later. We reviewed 7 patients with this translocation reported in the literature. Acquired Robertsonian translocations are rare, but could represent an important event in the tumorigenesis of hematologic malignancies.
Department of Medicine, Fujita Health University School of Medicine, Aichi, Japan.
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T
Ino
M
M
Okamoto
M
M
Tsuzuki
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I
Kamino
M
M
Hirano
D000328:Adult; D002882:Chromosomes, Human, Pair 13; D002884:Chromosomes, Human, Pair 15; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic