Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells.
We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1994) J. Biol. Chem. 269, 4709-4712] [corrected]. The possible role played by specific PTPases in cell differentiation is discussed.
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
K
K
Tsuneizumi
T
T
Kume
T
T
Watanabe
M F
MF
Gebbink
M L
ML
Thomas
M
M
Oishi
D000818:Animals; D018236:Carcinoma, Embryonal; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics*; D015342:DNA Probes; D004790:Enzyme Induction; D051379:Mice; D010960:Plasminogen Activators / Q000096:biosynthesis; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis*; D014158:Transcription, Genetic; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D015342:DNA Probes; D012333:RNA, Messenger; D014212:Tretinoin; D017027:Protein Tyrosine Phosphatases; D010960:Plasminogen Activators