A novel serine proteinase-like sequence from human brain.
From Alzheimer's visual cortex mRNA, a novel cDNA sequence with homology to the carboxy-terminal two-thirds of known serine proteinases was isolated (43% identity with human trypsinogen II). The corresponding mRNA has a size of approximately 8 kb and is expressed in low amounts in all human tissues tested.
Department of Biochemistry, University of Basel, Switzerland.
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Dihanich
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Spiess
D000544:Alzheimer Disease / Q000201:enzymology; D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000201:enzymology*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D012697:Serine Endopeptidases / Q000235:genetics*; D014793:Visual Cortex / Q000201:enzymology
D018076:DNA, Complementary; D012333:RNA, Messenger; D012697:Serine Endopeptidases