A pulsed-field gel electrophoresis map in the ataxia-telangiectasia region of chromosome 11q22.3.
Our interest in isolating the gene(s) for ataxia-telangiectasia has prompted us to construct a physical map of chromosome 11q22.3 using markers localized to this region by linkage analysis and/or hybrid cell panels. Twenty-two markers have been analyzed by pulsed-field gel electrophoresis. Nine of these markers form an approximately 2-Mb long-range contiguous map. An average distance of 200 kb between probes in this map should facilitate the isolation of new cDNAs, anonymous probes, and YACs in an orderly way.
Department of Pathology, School of Medicine, University of California, Los Angeles 90024.
N
N
Uhrhammer
P
P
Concannon
Y
Y
Huo
Y
Y
Nakamura
R A
RA
Gatti
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016521:Electrophoresis, Gel, Pulsed-Field / Q000379:methods; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells
D005819:Genetic Markers