[Differences in serum selenium concentration in probands and patients with colorectal neoplasms in Zagreb, Croatia].
Serum selenium concentration (scSe) (microgram/l) was comparatively measured in healthy persons (n = 202), patients with colorectal adenoma(s) (n = 44) and colorectal carcinoma (n = 48). In patients with adenoma(s) scSe (59.05 +/- 15) was significantly lower (p < 0.001) compared with scSe in the control group (66.8 +/- 14.43). Hyposelenemia was more pronounced in patients with multiple polyps (n = 11) than in patients with single adenoma (n = 33) (p < 0.05). Patients with colorectal carcinoma had also significant decrease in scSe (50.93 +/- 13.81) compared with the control group (p < 0.001 and with the adenoma patients (p < 0.001). According to the analysis of variance, highly significant differences were found among the cancer patients stratified in Dukes' stages A to D (p < 0.001), indicating a strong negative correlation between extension of cancer and hyposelenemia. Furthermore, hyposelenemia seemed to be more pronounced in the mucinous type of carcinoma than in adenocarcinoma (p = 0.056). This results indicate that hyposelenemia is strongly associated with colorectal neoplasia (including extension and severity of the disease) and that it may not only be a result but also one of tumorogenic factors. That means that selenium supplementation could be important in prevention or even adjuvant therapy of colorectal cancer.
Gastroenterologischen Abteilung der Inneren Klinik, Universitätsklinik, Rebro, Zagreb, Kroatien.
B
B
Vucelic
M
M
Buljevac
Z
Z
Romic
D
D
Milicic
R
R
Ostojic
Z
Z
Krznaric
D011125:Adenomatous Polyposis Coli / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D017523:Croatia; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012016:Reference Values; D012307:Risk Factors; D012643:Selenium / Q000097:blood*
D012643:Selenium
Unterschiede in den Selenkonzentrationen im Serum bei Gesunden und bei Patienten mit kolorektaler Neoplasie in Zagreb, Kroatien.