Alternating versus continuous drug regimens in combination chemotherapy of human immunodeficiency virus type 1 infection in vitro.
We compared the in vitro efficacies of two-, three-, and four-drug combinations given continuously or in alternating regimens against a clinical isolate of human immunodeficiency virus type 1. In H9 cells and peripheral blood mononuclear cells, at the drug concentrations used in this study, there was greater suppression of human immunodeficiency virus type 1 infection as the number of drugs in the regimen was increased from one to four simultaneously administered agents. Although alternating drug regimens were effective, they were not better than continuous administration of either single drugs or combinations of agents and were less effective than giving all drugs of an alternating regimen simultaneously.
Mazzulli
T
T
Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Rusconi
S
S
Merrill
D P
DP
D'Aquila
R T
RT
Moonis
M
M
Chou
T C
TC
Hirsch
M S
MS
D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002460:Cell Line; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000382:microbiology; D016133:Polymerase Chain Reaction; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents