Involvement of human papillomavirus type 20 in epidermodysplasia verruciformis skin carcinogenesis.
The involvement of human papillomavirus (HPV) in skin carcinogenesis in a patient with epidermodysplasia verruciformis was studied. This patient had disseminated pityriasis versicolor-like lesions, flat warts, and a malignant skin carcinoma. HPV types 3, 17, 20 (HPV-20), and 38 were isolated and molecularly cloned from the benign skin lesions of this patient. Of these HPVs, only HPV-20 was detected in the malignant skin carcinoma. Transcripts of HPV-20 were also expressed in the carcinoma. These findings suggest that HPV-20 was involved in the skin carcinogenesis in this patient.
Department of Tumor Virology, Osaka University, Suita, Japan.
M
M
Yutsudo
T
T
Tanigaki
R
R
Kanda
T
T
Sasagawa
T
T
Inoue
P
P
Jing
H
H
Yong-Il
A
A
Hakura
D000328:Adult; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D004819:Epidermodysplasia Verruciformis / Q000209:etiology* / Q000821:virology; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000209:etiology* / Q000821:virology; D015183:Restriction Mapping; D012878:Skin Neoplasms / Q000209:etiology* / Q000821:virology; D014412:Tumor Virus Infections / Q000209:etiology* / Q000821:virology
D004279:DNA, Viral