Toxic side effects of local anaesthetics on the human cornea.
The cytotoxic effects of 0.5% amethocaine (tetracaine) on the human cornea were investigated by scanning electron microscopy. The ultrastructural examination of epithelial cells showed damage of the cell membrane, rare-faction and loss of microvilli, deposits of amethocaine on the corneal surface and accelerated desquamation of superficial epithelial cells.
Boljka
M
M
Department of Ophthalmology, University Ljubljana, Slovenija.
Kolar
G
G
Vidensek
J
J
D002462:Cell Membrane / Q000187:drug effects; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000187:drug effects; D013748:Tetracaine / Q000009:adverse effects*
D013748:Tetracaine