[L-transforming effect of biseptol on cells of Shigella sonnei and flexneri].
Possible L-transformation of Shigella under the action of biseptol on an artificial nutrient medium was investigated. The L-forms were isolated from 6 out of 35 cultures. By the morphological properties the isolates were similar to the L-forms of Shigella flexneri induced by furazolidone. The growth of the L-forms proceeded by the pattern of the rapid mass L-conversion of bacteria and was accompanied by the development of resistance to biseptol. It was inhibited by folic acid added to the medium.
Fedorova
Z F
ZF
D004352:Drug Resistance, Microbial / Q000502:physiology; D005492:Folic Acid / Q000494:pharmacology; D005664:Furazolidone / Q000494:pharmacology; D012763:Shigella flexneri / Q000187:drug effects* / Q000235:genetics; D012764:Shigella sonnei / Q000187:drug effects* / Q000235:genetics; D014169:Transformation, Bacterial / Q000187:drug effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D005664:Furazolidone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D005492:Folic Acid
Izuchenie L-transformiruiushchego deĭstviia biseptola na kletki shigell Zonne i Fleksnera.