Cerebral schistosomiasis caused by Schistosoma haematobium: case report.
The CNS is an unusual site of ectopic infection in schistosomiasis. Cerebral lesions are caused primarily by Schistosoma japonicum, and spinal cord lesions are due primarily to Schistosoma mansoni and Schistosoma haematobium. S. haematobium is an unusual cause of cerebral mass lesions although schistosomal eggs can be frequently found in the brains of individuals in countries where S. haematobium is endemic. We describe a patient with a space-occupying cerebral lesion and schistosomal granulomas on pathological examination. S. haematobium was identified in urine and serologically. The cerebral lesion responded to therapy with praziquantel and corticosteroids. It has been postulated that granulomatous lesions develop following egg laying by errant worms migrating in the vicinity of the cerebral circulation or in response to eggs deposited from more distant sites by embolization. A species-specific serological diagnosis can be made by FAST (Falcon assay screening test)-ELISA with western blot confirmation.
Pollner
J H
JH
Department of Medicine, George Washington University Medical Center, Washington, D.C. 20037.
Schwartz
A
A
Kobrine
A
A
Parenti
D M
DM
D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005618:Fresh Water; D006801:Humans; D008295:Malawi; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage; D011223:Praziquantel / Q000008:administration & dosage; D012553:Schistosomiasis haematobia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
D010672:Phenytoin; D011223:Praziquantel; D003907:Dexamethasone