Measurement of volumetric coronary blood flow by simultaneous intravascular two-dimensional and Doppler ultrasound: validation in an animal model.
We examined the accuracy and feasibility of using simultaneous intracoronary Doppler and two-dimensional (2D) ultrasound imaging in the measurement of volumetric coronary blood flow (CBF). A femoral artery-to-circumflex coronary artery shunt was created in four dogs with tubing that incorporated an in-line transit-time ultrasound (TTU) flow probe. A 2D ultrasound catheter was introduced over a 0.014-inch Doppler guide wire into the circumflex artery with the guide wire tip positioned 2 cm beyond the imaging catheter tip. Cross-sectional area (CSA) and average peak velocity (APV) were recorded. CBF was determined from the previously validated relation CBF = CSA x 0.5 APV and the adjusted measurement formula CBF = CSA x 0.47 APV. Within the 119 measurements made, TTU CBF varied from 31 to 385 ml/min. An excellent correlation was found between 2D/Doppler-derived and TTU CBF with both constants; measurement agreement was improved and bias minimal with the 0.47 constant (slope = 0.9997; r = 0.99; p < 0.0001; SEE = -6.7 +/- 8.6). We conclude that simultaneous 2D and Doppler ultrasound yields accurate estimates of volumetric CBF.
Chou
T M
TM
Cardiology Division, Cardiovascular Research Institute, University of California at San Francisco 94143-0124.
Sudhir
K
K
Iwanaga
S
S
Chatterjee
K
K
Yock
P G
PG
D000818:Animals; D001783:Blood Flow Velocity; D001810:Blood Volume; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000502:physiology; D004285:Dogs; D005583:Fourier Analysis; D016014:Linear Models; D008955:Models, Cardiovascular; D018084:Ultrasonography, Interventional / Q000295:instrumentation / Q000379:methods