Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats.
The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca2+]i was significantly lower and [Mg2+]i was significantly higher in Mg group than in the control group. Further, [Ca2+]i was positively and [Mg2+]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca2+]i and [Mg2+]i, and modulates the development of hypertension.
Department of Pathology, Shimane Medical University, Izumo, Japan.
M
M
Adachi
Y
Y
Nara
M
M
Mano
Y
Y
Yamori
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000097:blood*; D004032:Diet; D006973:Hypertension / Q000209:etiology; D008214:Lymphocytes / Q000737:chemistry*; D008274:Magnesium / Q000097:blood* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
D008274:Magnesium; D002118:Calcium