The molecular biology of HIV. Insights into pathogenesis and targets for therapy.
In the past 10 years, a large number of investigators have produced an enormous amount of information concerning the molecular biology of HIV. These studies at the most basic biological level have provided essential insights into the pathogenesis of the disease. They have supplied the information necessary for the creation of the antiviral therapies now available and have indicated the direction for the development of new therapies now in clinical trials and under investigation. Although the relatively ineffective therapies currently available serve as a constant source of disappointment for those practitioners who care for HIV-infected patients, there is some comfort to be gained from the rapid pace of investigation into the basic biology of the virus and the certainty that any more effective therapy must build upon the basic biological knowledge already obtained. A detailed study of some of the unique features observed during pediatric and perinatal HIV infection, particularly the relatively shortened time from infection to symptoms and the relative importance of CNS disease, may suggest new therapeutic approaches that will benefit both adult and pediatric patients. Finally, a comprehensive knowledge of HIV biology is an essential requirement for therapeutic maneuvers designed to interrupt the transmission of HIV from mother to child.
Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
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D004279:DNA, Viral; D005260:Female; D015967:Gene Expression Regulation, Viral; D015686:Gene Products, env / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000648:ultrastructure; D015683:Gene Products, gag / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000648:ultrastructure; D015684:Gene Products, pol / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000648:ultrastructure; D006678:HIV / Q000737:chemistry / Q000235:genetics / Q000254:growth & development / Q000502:physiology / Q000648:ultrastructure; D015658:HIV Infections / Q000151:congenital / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D008967:Molecular Biology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000517:prevention & control; D012045:Regulatory Sequences, Nucleic Acid; D013997:Time Factors; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D014158:Transcription, Genetic; D054334:Viral Regulatory and Accessory Proteins / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000648:ultrastructure; D014771:Virion / Q000737:chemistry / Q000235:genetics / Q000254:growth & development / Q000502:physiology / Q000648:ultrastructure; D016662:Virus Integration; D014779:Virus Replication
D004279:DNA, Viral; D015686:Gene Products, env; D015683:Gene Products, gag; D015684:Gene Products, pol; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins