The 21-aminosteroid U-74389G protects the antioxidant enzymes in the ischemia/reperfusion-induced rat brain damage.
The antioxidant enzymatic system in the ischemia/reperfusion induced brain injury in rats after U-74389G administration was evaluated. Ischemia/reperfusion caused a decrease in the activities of superoxide dismutase and glutathione reductase, as well as of total and free sulfhydryl groups, while thiobarbituric acid-reactive substances became elevated. Administration of U-74389G lead to restoring to normal values of all above parameters. Protective effect of the drug in ischemia/reperfusion induced brain injury has been suggested.
Department of Analytical Chemistry, Medical Academy, Bialystok, Poland.
R
R
Farbiszewski
M
M
Chwiecko
J
J
Ustymowicz
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002545:Brain Ischemia / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008297:Male; D011281:Pregnatrienes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000201:enzymology*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D011281:Pregnatrienes; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; C074965:U 74389F; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase