Evaluation of a recombinant parasite antigen for the diagnosis of lymphatic filariasis.
We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from approximately 33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts.
S
S
Dissanayake
H
H
Zheng
G
G
Dreyer
M
M
Xu
L
L
Watawana
G
G
Cheng
S
S
Wang
P
P
Morin
B
B
Deng
L
L
Kurniawan
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology; D017178:Brugia malayi / Q000276:immunology*; D004605:Elephantiasis, Filarial / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D008842:Microfilariae / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D014958:Wuchereria bancrofti / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007106:Immune Sera; D007074:Immunoglobulin G; D011994:Recombinant Proteins