[Vitamin D3 transport across the intestines and its metabolism in the liver of rats with alloxan diabetes].
Vitamin D3 intestinal transport and liver metabolism were studied in rats with alloxan-induced diabetes. The condition was induced by i.v. alloxan injection in a dose of 40 mg/kg b.m. Diabetes development was monitored by blood serum glucose measurements, carried out for 30 days. [3H]-cholecalciferol absorption in the rat intestine was found inhibited in the diabetic animals as against the reference animals, which fact results in disordered entry of vitamin D3 to the body. [3H]-cholecalciferol absorption by the liver is reduced in the examined condition, and the time of its metabolism is increased more than threefold as against the reference animals. The share of vitamin D3 hydroxylation by the liver of diabetic rats is also significantly reduced. The described disorders are responsible, among other things, for the reduction of the levels of vitamin D3 active metabolites in the blood serum of rats with experimental diabetes.
L I
LI
Apukhovskaia
M V
MV
Stefanov
L V
LV
Antonenko
L I
LI
Omel'chenko
D000818:Animals; D001692:Biological Transport; D001786:Blood Glucose / Q000032:analysis; D002762:Cholecalciferol / Q000097:blood / Q000493:pharmacokinetics*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D002762:Cholecalciferol
Transport vitamina D3 cherez kishechnik i ego obmen v pecheni krys pri alloksanovom diabete.