[The synthesis and study of the acute toxicity and anthelmintic activity of salicylanilides containing a quinoline residue].
Salicylanilides containing quinoline moiety were synthesized and examined for acute toxicity and antinematodal activity. All the compounds were shown to possess a low toxicity. In the trials on a nematodal model (Aspiculuris tetraptera, white mice), 2 compounds--G-1570 and G-1575--were shown to be highly effective.
Khonkarov
Kh Zh
KhZh
Sevbo
D P
DP
Mikhaĭlitsyn
F S
FS
Veretennikova
N L
NL
Lykova
T I
TI
Lebedeva
M N
MN
Lychko
N D
ND
D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D010123:Oxyuriasis / Q000188:drug therapy; D011804:Quinolines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D012458:Salicylanilides / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D013329:Structure-Activity Relationship
D000969:Antinematodal Agents; D011804:Quinolines; D012458:Salicylanilides
Sintez, izuchenie ostroĭ toksichnosti i protivogel'mintnoĭ aktivnosti salitsilanilinov, soderzhashchikh ostatok khinolina.