Rifampin-induced nonresponsiveness of giant cell arteritis to prednisone treatment.
Rifampin is an enzymatic inducer known to increase steroid metabolism. We studied two patients with giant cell arteritis in whom rifampin caused nonresponsiveness to prednisone treatment. A prednisone pharmacokinetics study was done. When rifampin-prednisone treatment must be used in giant cell arteritis, we propose increasing the prednisone dosage to 2 mg/kg per day.
Carrie
F
F
Internal Medicine Service, University Hospital La Milétrie, Poitiers, France.
Roblot
P
P
Bouquet
S
S
Delon
A
A
Roblot
F
F
Becq-Giraudon
B
B
D000368:Aged; D005260:Female; D013700:Giant Cell Arteritis / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D011241:Prednisone / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012293:Rifampin / Q000494:pharmacology*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy
D011241:Prednisone; D012293:Rifampin