Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene.
A cDNA clone (hHLP2) encoding a novel calcium-binding protein structurally related to hippocalcin has been isolated from the human hippocampus cDNA library. The primary structure consists of 193 amino acids, and contains three EF-hand structures and a possible NH2-terminal myristoylation site. A single transcript at a position corresponding to 1.7 kilobases was detected only in the brain. The hHLP2 gene was mapped to human chromosome 2.
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
M
M
Kobayashi
K
K
Takamatsu
M
M
Fujishiro
S
S
Saitoh
T
T
Noguchi
D000595:Amino Acid Sequence; D001483:Base Sequence; D001923:Brain Chemistry; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D051597:Hippocalcin; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins / Q000235:genetics; D016415:Sequence Alignment
D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D051597:Hippocalcin