Platelet serotonin transporter in drug-naive migrainous children and adolescents.
Platelet [3H]imipramine binding was measured in 17 children and adolescents suffering from common (n = 10) and classical (n = 7) migraine and 10 healthy control subjects. All patients had more than a 1-year history of the disease and suffered at least one attack per month. All subjects had been drug-free for at least 4 weeks prior to the study and had never been treated with drugs active at the serotonergic system. An increased density in [3H]imipramine binding sites was detected in the migraine patients (+51%; p < 0.05). The increase in maximal binding was more prominent in the classical migraine group (+63%) than in the common migraine group (+43%). These results disagree with previous studies that reported decreased platelet imipramine binding in adult migraine patients. The discrepancy may be related to chronicity of drug treatment, long-term duration of disease and comorbidity of depression and anxiety disorders in adult migrainous patients.
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva, Israel.
A
A
Weizman
H
H
Fluhr
R
R
Weitz
R
R
Kehat
D
D
Inbar
A
A
Cohen
R
R
Mester
M
M
Rehavi
D000293:Adolescent; D000367:Age Factors; D001008:Anxiety Disorders / Q000453:epidemiology; D001792:Blood Platelets / Q000737:chemistry*; D002648:Child; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D011985:Receptors, Serotonin / Q000032:analysis* / Q000378:metabolism
D011985:Receptors, Serotonin