Xenobiotic metabolism in idiopathic Parkinson's disease in Nigerian Africans.
The acetylator phenotype using sulphadimidine as a probe drug was studied in 20 idiopathic Parkinson's disease (IPD) patients and 21 control subjects. 10(50%) of the IPD patients belonged to the slow acetylator phenotype but this did not differ significantly from the proportion 7 (33%) of control subjects who were slow acetylators. The result does not suggest a role for acetylation in the aetiopathogenesis of IPD in Nigerian African.
Igbokwe
E
E
Department of Medicine, University of Ibadan, Nigeria.
Ogunniyi
A O
AO
Osuntokun
B O
BO
D000107:Acetylation; D000367:Age Factors; D000368:Aged; D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D003124:Colorimetry; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D010641:Phenotype; D012720:Severity of Illness Index; D013418:Sulfamethazine / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism*
D015262:Xenobiotics; D013418:Sulfamethazine