Interaction of U-50,488H and noradrenergic systems on isolated right atria.
1. The present study examined the effect of U-50,488H on auricular rate on isolated right atria of the rat. 2. The negative chronotropic action induced by the kappa-agonist (U-50,488H) was potentiated by propranolol (10(-8) or 5 x 10(-8) M) or yohimbine (5 x 10(-7) or 10(-6) M) and in reserpinized rats (5 mg/kg i.p. 24 h before the experiments). 3. These results suggest that catecholaminergic mechanisms are involved in the cardiac depressant effect induced by U-50,488H.
Micol
J A
JA
Department of Physiology and Pharmacology, CSV Arrixaca Hospital, Murcia, Spain.
Laorden
M L
ML
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D000959:Antihypertensive Agents; D011759:Pyrrolidines; D015016:Yohimbine; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D012110:Reserpine; D011433:Propranolol; D009638:Norepinephrine