Determination of volatile organic contaminants in bulk oils (edible, injectable, and other internal medicinal) by purge-and-trap gas chromatography/mass spectrometry.
Purge-and-trap gas chromatography/mass spectrometry is evaluated for the quantitation of part-per-billion levels of volatile organic contaminants in bulk vegetable oils. Results using 2 purge techniques (direct purging of the heated oil and purging after dispersing the oil on an aluminum oxide powder) and 2 quantitative methods (standard curve and deuterium-labeled internal standard addition) are reported. Twenty volatile compounds and 8 vegetable oils were investigated. Recovery data and estimated detection limits for each compound are reported for each purge technique. Generally acceptable recoveries (70-130% for more than 90% of the analyte spikes) and acceptable detection levels (approximately 4-10 ppb) were obtained for all compounds using either the external standard curve or the deuterium-isotope-labeled internal standard. The use of a dispersant (such as alumina) for sample purging resulted in poor recoveries of the highly volatile contaminants.
U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309.
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Thompson
D000537:Aluminum Oxide; D003903:Deuterium; D005506:Food Contamination; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D006358:Hot Temperature; D006838:Hydrocarbons / Q000032:analysis*; D010938:Plant Oils / Q000737:chemistry*; D014835:Volatilization
D006838:Hydrocarbons; D010938:Plant Oils; D003903:Deuterium; D000537:Aluminum Oxide