A pulsed-field gel electrophoresis map in the ataxia-telangiectasia region of chromosome 11q22.3.
Our interest in isolating the gene(s) for ataxia-telangiectasia has prompted us to construct a physical map of chromosome 11q22.3 using markers localized to this region by linkage analysis and/or hybrid cell panels. Twenty-two markers have been analyzed by pulsed-field gel electrophoresis. Nine of these markers form an approximately 2-Mb long-range contiguous map. An average distance of 200 kb between probes in this map should facilitate the isolation of new cDNAs, anonymous probes, and YACs in an orderly way.
Uhrhammer
N
N
Department of Pathology, School of Medicine, University of California, Los Angeles 90024.
Concannon
P
P
Huo
Y
Y
Nakamura
Y
Y
Gatti
R A
RA
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016521:Electrophoresis, Gel, Pulsed-Field / Q000379:methods; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells
D005819:Genetic Markers