[Influence of colchicine upon morphology of intervertebral disc of rabbit].
The morphological changes of intervertebral disc of rabbit in the culture liquids of containing colchicine was observed by microscopy and transmission microscopy and hydroxyproline density of culture liquids was measured by stages. Meanwhile, set up control groups. Undiscovery that colchicine can produce discolysis and shrinking. We regard as major mechanism of colchicine treating herniated of intervertebral disc is anti-inflammation and anti-microtubule. We advance opposite viewpoint for Michael R. Rask's hypothesis which colchicine can produce herniated of intervertebral disc shrinking.
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Department of Orthopedics, Affiliated Hospital of Qinghai Medical College, Xining.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D003470:Culture Media / Q000378:metabolism; D046508:Culture Techniques; D006909:Hydroxyproline / Q000378:metabolism; D007403:Intervertebral Disc / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011817:Rabbits
D003470:Culture Media; D006909:Hydroxyproline; D003078:Colchicine