[The monoaminergic control of amygdaloid nuclei of the reinforcing action of conditioned stimuli].
Microinfusions of 5-HT and NA (30-50 mcg; 5 mcl) into the amygdalar nuclei (the central nucleus) were found to induce, correspondingly, inhibition and enhancement of acquired forms of behaviour conditioned by reinforcing, goal-directed action of phasic and instrumental-situational stimuli. After DA microinfusions in doses of 30-60 mcg various alterations of conditioned activity were observed in different animals resembling the results of 5-HT or NA action. Inhibitory action of 5-HT and excitatory action of NA in the amygdala are supposed to provide a structural work of stimuli reinforcing value perception and trans-switching of the behaviour to the stimuli. It is assumed that such mental departures in humans as emotional dullness and increased automatism may be developed during an increased endogenous 5-HT release in the amygdala. On the contrary, delay at the intermediate goals and application of the main motive to subsidiary operations may be underlain by NA release.
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EM
Melikov
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EO
Baĭramova
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology*; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D017982:Receptors, Biogenic Amine / Q000187:drug effects / Q000502:physiology*; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000494:pharmacology
D015306:Biogenic Monoamines; D017982:Receptors, Biogenic Amine; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine
Monoaminergicheskiĭ kontrol' iader amigdaly podkrepliaiushchego deĭstviia uslovnykh razdrazhiteleĭ.