Serum beta-endorphin in non-dialysed and haemodialysed patients with chronic renal failure.
Endogenous opioid peptides play an important role in the pathogenesis of uraemic syndrome. The effect of insulin-induced hypoglycaemia on serum beta-endorphin (BE) concentration was studied in 27 uraemic patients and in 14 healthy subjects. Despite elevated basal BE level, that correlated positively with serum creatinine, uraemic patients showed a normal BE secretory pattern. No differences were found between uraemic patients on conservative and those on haemodialysis treatment. The influence of haemodialysis treatment on BE secretion requires further investigations.
Department and Clinic of Internal Medicine and Occupational Diseases, Zabrze, Poland.
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Grzeszczak
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Drabczyk
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000628:therapy; D001615:beta-Endorphin / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D001615:beta-Endorphin