Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II.
There are unusual cases of pemphigus that have antibodies nonreactive with either pemphigus vulgaris or pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of pemphigus vulgaris and pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein.
Department of Dermatology, Warsaw School of Medicine, Poland.
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TP
Chorzelski
T
T
Hashimoto
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T
Nishikawa
T
T
Ebihara
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M
Dmochowski
M
M
Ismail
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Jabłońska
D000328:Adult; D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D051187:Desmocollins; D003896:Desmosomes / Q000276:immunology*; D004820:Epidermolysis Bullosa / Q000150:complications / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008175:Lung Neoplasms / Q000150:complications* / Q000276:immunology; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology
C081560:DSC1 protein, human; C081561:DSC2 protein, human; D051187:Desmocollins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins