The origin of isochromosomes and their significance in tumorigenesis of human lung cancer.
Isochromosomes related to chromosomes 1, 5, 6, 8, and 9 were frequently observed in 23 cases of lung cancer. Their existence in tumor cells might be nonrandom. Premature centromere separation (PCS) was found in the PGT-131 cell line of a lung cancer. It is suggested that PCS may play a role in the formation of isochromosomes in lung cancer.
Department of Biology, Harbin Medical College, China.
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D000230:Adenocarcinoma / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002460:Cell Line; D002869:Chromosome Aberrations; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008207:Lymphatic Metastasis