[Prevention of duodenal ulcer recurrence with penicillin].
The aim of this study was to test the hypothesis that infection with Helicobacter pylori is essential for recurrence of duodenal ulcer. We performed a randomized controlled trial of the relapse rate of duodenal ulcer during 12 weeks treatment with penicillin V or placebo in 170 out-patients from five centres. The relapse rate was 9% during treatment with penicillin and 50% with placebo, P < 0.0001. It is concluded that infection with penicillin-sensitive bacteria, i.e. H. pylori, plays an important role for recurrence of duodenal ulcer disease. Penicillin V suppresses this infection but does not eradicate it.
Rune
S J
SJ
Medicinsk gastroenterologisk afdeling F, Amtssygehuset i Glostrup.
Justesen
T
T
Hansen
J M
JM
Jensen
T G
TG
Eriksen
J
J
Thomsen
O O
OO
Scheibel
J H
JH
Bonnevie
O
O
Bremmelgaard
A
A
Vilien
M
M
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010404:Penicillin V / Q000627:therapeutic use*; D012008:Recurrence
D010404:Penicillin V
Forebyggelse af recidiv af ulcus duodeni med penicillin.