Effects of sulfur dioxide exposure on African-American and Caucasian asthmatics.
There is concern that air pollution may be causing increases in asthma morbidity and mortality, especially among African-Americans. It is possible that there may be ethnic differences in susceptibility. To evaluate this speculation, a comparative pilot study of respiratory function in 10 African American and 12 Caucasian methacholine positive asthmatic males was conducted. Subjects were exposed to pure air or 1 ppm SO2 while breathing inside a polycarbonate head dome, for 10 min of rest and 10 min of exercise. Baseline and postexposure pulmonary function measurements were recorded, and nasal lavage fluid samples were collected and processed for epithelial and white blood counts. Although significant increases were seen in total respiratory resistance following SO2 exposure in both groups (P = 0.04), no ethic-based difference in response was seen. No significant differences were found in pulmonary or nasal measurements after exposure to SO2 between African-American and Caucasian subjects. No significant changes in epithelial or white blood cell count were found either when data were analyzed from the entire group or separately from the two subject groups. Even though there were no significant group changes, some individuals were particularly responsive to SO2. Three Caucasian and 5 African-American subjects showed greater than 20% increases in total respiratory resistance.
Department of Environmental Health, University of Washington, Seattle 98195.
S K
SK
Heath
J Q
JQ
Koenig
M S
MS
Morgan
H
H
Checkoway
Q S
QS
Hanley
V
V
Rebolledo
D000328:Adult; D001249:Asthma / Q000097:blood / Q000503:physiopathology*; D044383:Black People; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010865:Pilot Projects; D013458:Sulfur Dioxide / Q000009:adverse effects*; D014481:United States; D044465:White People; D001741:Black or African American
D013458:Sulfur Dioxide