[The characteristics of CD18, CD11b, CD4, CD8 and CD3 antigen expression detectable by ICO monoclonal antibodies in the blood of hemoblastosis patients].
CD18-positive cells (beta-chain of antigen LFA-1), cells CD11b+, CD4+, CD8+ and CD3+ were quantified in the blood of 32 acute leukemia patients, 38 chronic lymphoid leukemia patients and 15 mature-cell lymphosarcoma patients. A standard reaction of indirect immunofluorescence was employed using ICO monoclonal antibodies. Alterations in the content and in the proportions of the main effector populations in the peripheral blood of hemoblastosis patients were observed. These were more apparent in the unfavourable course of acute leukemia and in chronic lymphoid leukemia. The defect was more marked in CD18+ and CD11b+ cells expressing antigen LFA-I. Reduced expression of LFA-I considerably contributes to impairment of antitumor resistance in hemoblastosis.
Glazanova
T V
TV
Bubnova
L N
LN
Kochetkova
G A
GA
Khoroshaĭlova
A E
AE
D000208:Acute Disease; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000097:blood*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D011379:Prognosis
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D016169:Lymphocyte Function-Associated Antigen-1
Osobennosti ékspressii antigenov CD18, CD11b, CD4, CD8, CD3, vyiavliaemykh monoklonal'nymi antitelami serii IKO, v krovi bol'nykh gemoblastozami.