Biospecific haemosorbents based on proteinase inhibitor. II. Efficiency of biospecific antiproteinase haemosorbent 'Ovosorb' in complex treatment of experimental generalized purulent peritonitis and acute destructive pancreatitis in dogs.
The biospecific antiproteinase haemosorbent (BAH) 'Ovosorb' containing, in the bulk of polyacryamide gel, the ovomucoid from whites of duck eggs, was used for a complex treatment of the experimental generalized purulent peritonitis and acute destructive pancreatitis in dogs. The efficiency of BAH was manifested in the significant reduction of lethality of the experimental animals, a more rapid liquidation of proteinasaemia, normalization in plasma of alpha 1-proteinase inhibitor and protein metabolism. Thus, by eliminating proteinases from circulation, Ovosorb contributes to the cessation of imbalance in the proteinase-inhibitor system and is efficient in the therapy of pathological states related to this imbalance.
Platé
N A
NA
Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow.
Kirkovsky
V V
VV
Antiperovich
O F
OF
Nicolaichik
V V
VV
Valueva
T A
TA
Sinilo
S B
SB
Moin
V M
VM
Lobacheva
G A
GA
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D010059:Ovomucin / Q000627:therapeutic use*; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use*; D013492:Suppuration
D011480:Protease Inhibitors; C073841:Ovosorb; D010059:Ovomucin