Oxidative stress and apoptosis in HIV infection: a role for plant-derived metabolites with synergistic antioxidant activity.
The cascade of events resulting from 'oxidative stress' is markedly similar to that which can initiate apoptosis, a possible mechanism of immune-cell loss in patients with HIV infection and AIDS. Since primary and secondary metabolites found in plants can act as synergistic antioxidants, and can prevent oxidation-induced cell death, Howard Greenspan and Okezie Aruoma ask whether or not these compounds can be useful in inhibiting viral activation and the death of immune cells in HIV/AIDS.
LGD Biomedical Group, Annandale, NJ 08801.
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HC
Greenspan
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Aruoma
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D010944:Plants / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species