Full-term pregnancy with embryos from donated oocytes in a 36-year-old woman allografted for chronic myeloid leukemia.
We report the first case of full-term pregnancy arising from donated oocytes in a 36-year-old woman with chronic myeloid leukemia (CML), 6 years after allogeneic bone marrow transplantation (BMT) following total body irradiation (TBI) (12 Gy) and cyclophosphamide 120 mg/kg. The first attempt at implantation with her own cryopreserved ovocytes was unsuccessful. Thereafter, she became pregnant after donated oocyte implantation using estradiol and progesterone support replacing the defective ovarian function. The baby was normal. Unfortunately, 6 months later, she relapsed in chronic phase of CML.
Service d'Hématologie, Hôtel-Dieu, Paris, France.
B
B
Rio
H
H
Letur-Könirsch
F
F
Ajchenbaum-Cymbalista
F
F
Bauduer
D
D
De Ziegler
C
C
Pelissier
A
A
Bernadou
R
R
Frydman
R
R
Zittoun
D000328:Adult; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage; D004624:Embryo Transfer; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D015466:Leukemia, Myeloid, Chronic-Phase / Q000209:etiology; D009865:Oocytes; D010053:Ovary / Q000528:radiation effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy / Q000209:etiology; D011374:Progesterone / Q000627:therapeutic use; D011832:Radiation Injuries / Q000209:etiology; D014019:Tissue Donors; D014916:Whole-Body Irradiation / Q000009:adverse effects
D011374:Progesterone; D004958:Estradiol; D003520:Cyclophosphamide