Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.
The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption.
Damonte
E
E
Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Neyts
J
J
Pujol
C A
CA
Snoeck
R
R
Andrei
G
G
Ikeda
S
S
Witvrouw
M
M
Reymen
D
D
Haines
H
H
Matulewicz
M C
MC
D000998:Antiviral Agents / Q000302:isolation & purification*; D005591:Chemical Fractionation; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000302:isolation & purification*; D012624:Seaweed / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011134:Polysaccharides