[Fertility disorders in 49 hyperandrogenic women desiring pregnancy. Treatment results aimed at obtaining a pregnancy in 40 hyperandrogenic infertile women and in 9 hyperandrogenic women desiring pregnancy].
The clinical and therapeutic aspects of fertility due to hyperandrogenism were studied in 49 women (40 presenting with sterility and 9 for another reason but seeking to become pregnant). Patients were divided into three main etiological groups on the basis of hormonal findings: ovarian (15 cases), adrenal (16 cases) and mixed (11 cases) hyperandrogenism. This study highlighted several points. 22% of infertile women had no cutaneous signs of hyperandrogenism and menstrual disturbances were missing in 46% of cases of adrenal hyperandrogenism. Primary infertility was seen more often in all types of hyperandrogenism (28 cases) than secondary infertility (12 cases). Secondary infertility was explained by a high early spontaneous abortion rate in hyperandrogenism (40%). This was much commoner in adrenal hyperandrogenism than in ovarian or mixed hyperandrogenism. Inducing treatment based upon a combination of dexamethasone and clomiphene citrate proved to be the most effective in these infertile women (86% pregnancy rate). The frequency of spontaneous abortions in infertility due to ovarian or mixed hyperandrogenism treated by clomiphene citrate alone can probably be explained by the persistence of hyperandrogenism.
Service d'Endocrinologie, Diabétologie, Nutrition, Hôpital Notre-Dame de Bon Secours, Paris.
J P
JP
Cordray
R E
RE
Merceron
B
B
Siboulet
X
X
Guillerd
P
P
Nys
P
P
Reboul
M
M
Rainaut
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000293:Adolescent; D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications* / Q000175:diagnosis; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D002996:Clomiphene; D003907:Dexamethasone
Troubles de la fertilité chez 49 femmes hyperandrogéniques désirant une grossesse. Résultats des traitements visant à obtenir une grossesse chez 40 femmes hyperandrogéniques infertiles et chez 9 femmes hyperandrogéniques désirant une grossesse.