Immunogenicity of an inactivated hepatitis A vaccine after exposure at 37 degrees C for 1 week.
The reactogenicity and immunogenicity of a recently released lot of inactivated hepatitis A vaccine (Havrix) were compared after storage at 37 degrees C for 1 week and at the recommended storage temperature of 2-8 degrees C, in two groups of healthy adults in a randomized, double-blind controlled study. The reactogenicity, geometric mean concentrations and seroconversion rates were all similar in both groups, confirming the good thermal stability of the vaccine.
Institut für Spezifische Prophylaxe und Tropenmedizin Universität, Wien, Austria.
G
G
Wiedermann
F
F
Ambrosch
D000328:Adult; D004311:Double-Blind Method; D004355:Drug Stability; D004356:Drug Storage; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies / Q000096:biosynthesis*; D006801:Humans; D011309:Preservation, Biological; D013696:Temperature; D015164:Vaccines, Inactivated / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines