[A pharmacokinetic analysis of Gd-DTPA enhancement in MRT in breast carcinoma].
Dynamic Gd-DTPA enhanced MR of the breast was performed in one single slice in 27 patients with suspicious nodular lesions. The results could be histologically verified in all cases. A rapid spin-echo sequence with a time resolution of 8.75 s was used for the dynamic examination. The signal changes were analysed using a pharmacokinetic model which allowed parametrization of the contrast enhancement and transformation of the data into colour coded parameter images. The parameters allowed reliable distinction of 9 benign from 18 malignant lesions (p < 0.05 for "amplitude", p < 0.001 for "k21"). One fibroadenoma could not be distinguished from the carcinomas. Lymph node metastases and the pharmacokinetic parameter amplitude correlated significantly (p < 0.05).
Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Heidelberg.
T
T
Hess
M V
MV
Knopp
U
U
Hoffmann
G
G
Brix
H
H
Junkermann
I
I
Zuna
D
D
von Fournier
G
G
van Kaick
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D003287:Contrast Media / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D005260:Female; D005682:Gadolinium / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008875:Middle Aged; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D010865:Pilot Projects
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
Pharmakokinetische Analyse der Gd-DTPA-Anreicherung in der MRT beim Mammakarzinom.