ACTH-(11-24) antagonizes ACTH-(1-24)-induced behavioral syndrome.
The possible involvement of the ACTH-(11-24) fragment on the stretchings, yawnings and penile erections induced by the intracerebroventricular injection of ACTH-(1-24) in rats, was studied. The results indicate that this C-terminal fragment is devoid of any behavioral activity, but inhibits the behavioral syndrome induced by ACTH-(1-24). This suggests that the fragment-(11-24) of the ACTH molecule may contain or represent an address sequence for brain ACTH receptors and may be involved in the termination of the behavioral response to melanocortins.
Genedani
S
S
Institute of Pharmacology, University of Modena, Italy.
Bernardi
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003366:Cosyntropin / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D010410:Penile Erection / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010446:Peptide Fragments; D003366:Cosyntropin; C034016:ACTH (11-24)