Cell cycle control and cancer chemotherapy.
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to metabolic perturbations of stress. Impaired cell cycle regulation would make cells vulnerable to pharmacologic intervention by drug regimens tailored to the defects existing in particular tumors. Recent findings that may become applicable to therapy are reviewed, and the possible form of new therapeutic stratagems is considered.
Laboratory of Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
K W
KW
Kohn
J
J
Jackman
P M
PM
O'Connor
D002453:Cell Cycle / Q000235:genetics*; D004249:DNA Damage; D004261:DNA Replication; D016193:G1 Phase / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008938:Mitosis / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D016196:S Phase / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D016159:Tumor Suppressor Protein p53