Basement membrane components as differential markers for mesenchymal tumors of various origin.
We immunohistochemically analyzed the presence or absence of a pericellular basement membrane in benign and malignant soft tissue tumors of different origin--of peripheral nerve, smooth and striated muscle, fat tissue, connective tissue, blood and lymph vessels, cartilage and bone--to test the role of the expression of the BM components collagen IV, laminin, heparan sulfate proteoglycan (HSPG) and fibronectin as a differential diagnostic aid. All benign tumors revealed a BM feature corresponding to that of the normal tissue. Well differentiated sarcomas similarly showed a BM pattern close to that of the respective normal mesenchymal cells, so that these sarcomas were attributable to different histogenetic entities. Low differentiated sarcomas preserved in some, but not all, instances a typical BM pattern as well. Since the BM expression in most sarcomas of lesser degree of differentiation shows a distinctive BM pattern, we believe that the BM analysis of soft tissue sarcomas may be useful to establish a proper histogenetic classification of mesenchymal tumors.
Nerlich
A G
AG
Pathologisches Institut der Universität, München, Federal Republic of Germany.
Haraida
S
S
Wiest
I
I
D001485:Basement Membrane / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D003094:Collagen / Q000032:analysis*; D005353:Fibronectins / Q000032:analysis*; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate / Q000032:analysis*; D006801:Humans; D007797:Laminin / Q000032:analysis*; D008637:Mesenchymoma / Q000473:pathology*; D011509:Proteoglycans / Q000032:analysis*; D012016:Reference Values; D012509:Sarcoma / Q000473:pathology*
D014408:Biomarkers, Tumor; D003094:Collagen; D005353:Fibronectins; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate; D007797:Laminin; D011509:Proteoglycans