Comparison of assay methods by second-derivative spectroscopy, colorimetry and fluorescence spectroscopy of salicylic acid in aspirin preparations with a high-performance liquid chromatographic method.
Second-derivative spectroscopy, colorimetry and fluorescence spectroscopy have been compared with a high-performance liquid chromatographic (HPLC) method for the assay of salicylic acid in preparations of aspirin. Results are presented for the linearity, sensitivity and reproducibility of these methods. The second-derivative spectroscopic and the HPLC methods were acceptable in terms of linearity, sensitivity and inter-day reproducibility and were convenient for the routine analysis of salicylic acid in aspirin preparations.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Complutense University, Madrid, Spain.
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D001241:Aspirin / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003124:Colorimetry; D015203:Reproducibility of Results; D012459:Salicylates / Q000032:analysis*; D020156:Salicylic Acid; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000737:chemistry
D012459:Salicylates; D013607:Tablets; D020156:Salicylic Acid; D001241:Aspirin