Immunogenicity of an inactivated hepatitis A vaccine after exposure at 37 degrees C for 1 week.
The reactogenicity and immunogenicity of a recently released lot of inactivated hepatitis A vaccine (Havrix) were compared after storage at 37 degrees C for 1 week and at the recommended storage temperature of 2-8 degrees C, in two groups of healthy adults in a randomized, double-blind controlled study. The reactogenicity, geometric mean concentrations and seroconversion rates were all similar in both groups, confirming the good thermal stability of the vaccine.
Wiedermann
G
G
Institut für Spezifische Prophylaxe und Tropenmedizin Universität, Wien, Austria.
Ambrosch
F
F
D000328:Adult; D004311:Double-Blind Method; D004355:Drug Stability; D004356:Drug Storage; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies / Q000096:biosynthesis*; D006801:Humans; D011309:Preservation, Biological; D013696:Temperature; D015164:Vaccines, Inactivated / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines