The expression of Candida albicans enolase is not heat shock inducible.
An isoprotein of enolase from the yeast Saccharomyces cerevisiae was reported to be a heat shock protein. The possible role of the C. albicans enolase as a heat shock protein was therefore investigated. The de novo synthesis of C. albicans enolase protein and mRNA did not increase during heat stress, but remained constitutively expressed. Amino acid similarity to the heat shock proteins suggests that although the C. albicans enolase is not a classical heat shock protein, it may be a member of a group of constitutively expressed, structurally related proteins, the heat shock cognate proteins.
School of Biomedical Sciences, Curtin University of Technology, Perth, Australia.
K M
KM
Franklyn
J R
JR
Warmington
D000595:Amino Acid Sequence; D000908:Antibodies, Fungal; D015152:Blotting, Northern; D015153:Blotting, Western; D002176:Candida albicans / Q000201:enzymology / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000276:immunology; D006358:Hot Temperature; D016056:Immunodominant Epitopes / Q000235:genetics / Q000276:immunology; D008969:Molecular Sequence Data; D010751:Phosphopyruvate Hydratase / Q000235:genetics* / Q000276:immunology; D011233:Precipitin Tests; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D000908:Antibodies, Fungal; D006360:Heat-Shock Proteins; D016056:Immunodominant Epitopes; D010751:Phosphopyruvate Hydratase