Molecular biology of voltage-gated K+ channels in heart.
The recent cloning of numerous voltage-activated K+ channels provides new information concerning the architecture of K+ channel proteins. The combination of molecular genetic and biophysical methods gives us a new insight into the molecular mechanisms of K+ channel pharmacology.
Institut de Pharmacologie Moléculaire et Cellulaire, Sophia Antipolis, Valbonne, France.
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Honoré
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Lesage
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Romey
D000200:Action Potentials; D000595:Amino Acid Sequence; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D003001:Cloning, Molecular; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000737:chemistry / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*
D000889:Anti-Arrhythmia Agents; D015221:Potassium Channels