WR-1065 as a chemoprotector in Adriamycin chemotherapy.
The protective effect of WR-1065 against the side effects of Adriamycin was studied in tumor bearing mice. It has been noticed that WR-1065 pretreatment improved the Adriamycin toxicities such as increased enzyme levels, pathological lesions in lung, liver and heart and increased rate of lipid peroxidation, without reducing its anticancer property.
Government Medical College, Trichur, Kerela, India.
P
P
Bhanumathi
E D
ED
Saleesh
D M
DM
Vasudevan
D000818:Animals; D004249:DNA Damage; D004317:Doxorubicin / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008624:Mercaptoethylamines / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C
D008624:Mercaptoethylamines; C020174:N-(2-mercaptoethyl)-1,3-diaminopropane; D004317:Doxorubicin