[Investigation of chlorfenvinphos influence on levels of free tryptophan in blood plasma of the rat].
The authors studied the effect of chlorfenvinphos on the free tryptophan level in the plasma of blood of male Wistar rats. The animals were intoxicated with pesticide in a single oral dose of 2.6 mg/kg (0.2 LD50). The tryptophan was assayed spectrophotometrically after 2, 4, 24 and 72 hours following administration of the insecticide. The obtained results indicate that after intoxication with chlorfenvinphos there are no changes in the free tryptophan level after 2, 4 and 24 hours. After 72 hours a significant increase of this amino acid level was observed. Inhibition of the tryptophan elimination by kidney or disturbance of dynamic equilibrium in the distribution between plasma and erythrocytes, probably is the cause of this change in concentration.
Katedry i Zakładu Chemii Toksykologicznej Akademii Medycznej, Lublinie.
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Szczepaniak
D000818:Animals; D002709:Chlorfenvinphos / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014364:Tryptophan / Q000097:blood*
D014364:Tryptophan; D002709:Chlorfenvinphos
Badanie wpływu chlorfenwinfosu na poziom wolnego tryptofanu w osoczu krwi szczura.