[Effects of blood volume expansion on atrial natriuretic factor and the renin-aldosterone axis in experimental cirrhosis].
Serum concentrations of ANF, Renin and Aldosterone were measured in animals with experimental cirrhosis and volume overload. We studied 75 Wistar rats divided in five groups. Group I: rats with hepatic cirrhosis induced by CCl4; Group II: Control rats; Group III: rats with hepatic cirrhosis and continuous infusion of saline serum; Group IV: control rats with continuous infusion and Group V: cirrhotic rats and bolus infusion of saline. There were no statistical differences in serum concentrations of ANF (232 +/- 75 vs 195 +/- 42 pg/ml) and Renin concentration (182 +/- 24 vs 171 +/- 34 ng/ml/hour) between controls and rats with cirrhosis. However, Aldosterone levels were elevated in cirrhotic rats in basal conditions as compared to controls (1197 +/- 287 vs 475 +/- 88 pg/ml; p < 0.001). The volume overload caused a paradoxical decrease of ANF in cirrhotic rats (124 +/- 15 and 122 +/- 17; p < 0.001). On the other hand, no changes were observed in Renin and Aldosterone after volume expansion. These results suggest the existence of a hemodynamic response to compensate the volume overload. Other studies are necessary to confirm this hypothesis.
Servicio de Aparato Digestivo, Hospital General Miguel Servet, Zaragoza.
J J
JJ
Sebastián Domingo
F
F
Barrao Comps
F
F
Esteva Díaz
G
G
Ceña Lázaro
M
M
Arroyo
T
T
Serrano
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001810:Blood Volume; D008106:Liver Cirrhosis, Experimental / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood*
D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin
Efectos de la expansión de la volemia sobre el factor auricular natriurético y el eje renina-aldosterona en la cirrosis experimental.