Role of oxygen free radicals in altitude-related disorders.
A massive expansion of mountain tourism and the practice of sports at altitude (mountaineering, skiing, cycling, hang-gliding, parapente, etc) has been observed in the last decades. This emphasis on new forms of sports and recreation represented as a social phenomenon is accompanied by an increase in the mountain associated-disorders and related-accidents. These include headache, lassitude, pain, difficulty in breathing, rapid heartbeat, and in the worst of the cases loss of consciousness, always possible, manifest by poor judgement, fatigue, etc, and death. However, medical studies are rare, mainly because the molecular mechanisms of tissue damage induced by oxygen free radicals are still poorly understood. Therefore, the goals of the present report are: 1) to summarize the main adaptations of the body at high altitude, introducing the concepts of altitude sickness and oxygen free radicals and their relation; 2) to propose a mechanism of action of oxygen free radicals in the development of this pathology, with special attention in hypoxia and related mechanisms; 3) to suggest a role for antioxidants in the therapy of altitude-related disorders.
Roche
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Departement de Biochimie Clinique, CMU, Genève, Switzerland.
Romero-Alvira
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D
D000064:Acclimatization / Q000502:physiology; D000532:Altitude Sickness / Q000209:etiology* / Q000378:metabolism; D004734:Energy Metabolism; D005609:Free Radicals; D006801:Humans; D008954:Models, Biological; D009051:Mountaineering; D017382:Reactive Oxygen Species / Q000378:metabolism*
D005609:Free Radicals; D017382:Reactive Oxygen Species