[Interaction of antibiotics with leukocytes in children of various age groups].
The indices of binding of 21 currently used antibiotics to human peripheral leukocytes (the ratio of the cellular and extracellular concentrations) were determined experimentally in regard to various age periods, i.e. at the birth, from 1 to 3 years and from 5 to 9 years of the age. It was shown that during the period up to 5 years of the age the binding lowered, especially to the polymorphonuclear leukocytes and not so much to the lymphocytes. The different parameters of the cell pharmacokinetics in children should be taken into account in chemotherapy of bacterial infections with intracellular localization of the pathogen.
Guliaev
A E
AE
Karlinskiĭ
M V
MV
Gubenko
L V
LV
Kivman
G Ia
GIa
D000375:Aging / Q000097:blood*; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*
D000900:Anti-Bacterial Agents
Vzaimodeĭstvie antibiotikov s leĭkotsitami deteĭ v razlichnye vozrastnye periody.