Effect of oxygen free radicals on Mg2+ efflux from erythrocytes.
Hydrogen peroxide destroyed the Na+/Mg2+ antiport in Mg(2+)-loaded human and rat erythrocytes and increased the leakage of intracellular Mg2+ and K+. These effects are opposite to the increase of Na+/Mg2+ antiport and unchanged Na(+)-independent Mg2+ efflux from erythrocytes of patients with cystic fibrosis score 3. Thus, the increase of Na+/Mg2+ antiport in these patients is not caused by increased formation of free radicals.
Günther
T
T
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Germany.
Vormann
J
J
Förster
R M
RM
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000633:toxicity; D008274:Magnesium / Q000097:blood*; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000633:toxicity*
D017382:Reactive Oxygen Species; D008706:Methemoglobin; D006861:Hydrogen Peroxide; D008274:Magnesium; D011188:Potassium