An investigation of diterpenes from the leaves of Rabdosia trichocarpa and their antibacterial activity against oral microorganisms.
The ethanolic extract of Rabdosia trichocarpa leaves showed antibacterial activity against cariogenic mutans streptococci and periodontopathic Porphyromonas gingivalis. Chromatographic separation and purification of the extract afforded ten diterpenes, including one novel ent-kauren type compound named trichoranin. Some of these compounds possess potent antibacterial activity against these oral micro-organisms, indicating that these diterpenes may be useful natural substances for the maintenance of oral health.
Department of Basic Research, Lotte Central Laboratory Co., Ltd., Saitama, Japan.
K
K
Osawa
H
H
Yasuda
T
T
Maruyama
H
H
Morita
K
K
Takeya
H
H
Itokawa
K
K
Okuda
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D016966:Porphyromonas gingivalis / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects; D016986:Streptococcus sobrinus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts