Macrophage colony-stimulating factor enhances platelet recovery following cisplatin/carboplatin chemotherapy in ovarian cancer.
To assess the effects of macrophage colony-stimulating factor (M-CSF) on platelet recovery in patients given chemotherapy for advanced and recurrent ovarian cancer, we selected 29 cases treated with carboplatin (280 mg/m2, Day 1) and cisplatin (70 mg/m2, Day 2). We evaluated the response and the platelet recovery effects of M-CSF, which was infused intravenously for 7 consecutive days after the second and fourth courses of chemotherapy. For the 54 courses of M-CSF infusion, the platelet nadir averaged 12.8 +/- 6.3 x 10(4)/microliters, with 9% of the courses designated Grade 3 or 4 on the toxicity scale, according to World Health Organization recommendations, both of which were significantly different from the M-CSF noninfused control courses (P < 0.05). The number of periods in which platelets were below 7.5 x 10(4)/microliters was significantly less in the courses of M-CSF infusion (P < 0.01). Response to treatment was pathologic complete in 23% and partial in 41%, for a total response of 64%. Cisplatin combined with carboplatin was effective in treating patients with advanced and recurrent ovarian cancer. M-CSF infusion may enhance the recovery from the thrombocytopenia that accompanies such chemotherapy.
Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan.
M
M
Suzuki
M
M
Ohwada
I
I
Aida
I
I
Sato
T
T
Tamada
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D016173:Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010976:Platelet Count / Q000187:drug effects; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*
D016173:Macrophage Colony-Stimulating Factor; D016190:Carboplatin; D002945:Cisplatin