A novel human gene that is preferentially transcribed in heart muscle.
We have cloned a human cDNA fragment for a gene that is expressed primarily in the heart. To explore its biological function, we have isolated full-length cDNA clones of the gene. DNA sequencing of the 2.7-kb cDNA revealed a 2274-bp ORF. Close to the N terminus of the deduced amino acid sequence is a possible ATP-binding domain that has been assembled by a fusion of B- and A-type adenine nucleotide-binding motifs. In the middle of the sequence is a long stretch of alpha-helical residues that could form a coiled-coil. These features imply that this is a sequence encoding a new human motor protein.
Department of Molecular Cellular Oncology and Microbiology, Tokyo Medical and Dental University, Japan.
T
T
Icho
T
T
Ikeda
Y
Y
Matsumoto
F
F
Hanaoka
K
K
Kaji
N
N
Tsuchida
D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D018076:DNA, Complementary; D006801:Humans; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D017433:Protein Structure, Secondary; D051381:Rats; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic
D018076:DNA, Complementary; C088548:IMMT protein, human; D024101:Mitochondrial Proteins; D009124:Muscle Proteins; D000255:Adenosine Triphosphate