B-lineage differentiation in normal and transformed cells and the microenvironment that supports it.
B-cell differentiation is a complex process mediated through interactions with the microenvironment of the bone marrow and fetal liver. These interactions alter patterns of gene expression and allow precursors to develop into Ig+ B cells. Recent work has shown that some of these events can be triggered in B-cell precursors transformed by Abelson virus. Other advances have refined our understanding of the role of cytokines, hormones and stromal cells in the differentiation process.
Rosenberg
N
N
Tufts University School of Medicine, Boston.
Kincade
P W
PW
D000011:Abelson murine leukemia virus; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002461:Cell Line, Transformed / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D015322:Gene Rearrangement, B-Lymphocyte; D006728:Hormones / Q000502:physiology; D007107:Immune System / Q000254:growth & development; D015851:Interleukin-7 / Q000502:physiology
D015815:Cell Adhesion Molecules; D016207:Cytokines; D006728:Hormones; D015851:Interleukin-7