title: [The protective activity of a multicomponent vaccine made from the antigens of opportunistic microorganisms when administered orally].
abstract: Multicomponent vaccine VP-4, prepared from Streptococcus, Klebsiella, Proteus and Escherichia coli antigens, was tested for protective activity by oral administration to mice with experimental Klebsiella, Proteus and S. pneumoniae infections. Vaccine VP-4, when introduced orally (in 2-3 administrations of 2 mg), was found to produce a protective effect with respect to K. pneumoniae (the effectiveness index was equal to 5.7 and 4.3). With respect to P. vulgaris, the effectiveness index was 2.7 (immunization was made in two oral administrations of 2 mg); in pneumococcal infection preliminary oral immunization with vaccine VP-4 in two administrations in a dose of 2-4 mg produced high protective effect. Thus, immunization with vaccine VP-4, introduced orally in comparatively small doses, proved to be effective in animal models used in the experiment.
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: N L
authors.initials: NL
authors.lastname: Mansurova
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: K G
authors.initials: KG
authors.lastname: Kaverina
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology*; D007114:Immunization; D007710:Klebsiella Infections / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000276:immunology*; D007928:Lethal Dose 50; D051379:Mice; D011008:Pneumococcal Infections / Q000517:prevention & control; D011512:Proteus Infections / Q000517:prevention & control; D011514:Proteus vulgaris / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined
vernacular_title: Protektivnaia aktivnost' polikomponentnoĭ vaktsiny iz antigenov uslovnno-patogennykh mikroorganizmov pri oral'nom vvedenii.