[Critical evaluation of fibronectin in pregnancy-induced hypertension/pre-eclampsia and placental insufficiency].
1. Fibronectin does not correlate with the grade of proteinuria. 2. Fibronectin does not correlate with birth weight. 3. Fibronectin level is not elevated in pregnancy-induced hypertension and preeclampsia. 4. Fibronectin level is elevated in cases of preeclampsia, combined with chronic placental insufficiency respectively intrauterine growth retardation. 5. There is a statistic significant difference between pregnancy-induced hypertension/preeclampsia with or with out placental insufficiency. 6. Extremely problematic pregnancies ended in all pregnancies with values of fibronectin above 0.4 g/l in caesarean section without knowledge of the elevated fibronectin level at the time of operation. 7. In the group of pregnancy-induced hypertension the fibronectin level is elevated in relation to control group. This increase is particularly evident, if a placental insufficiency is concontinant with preeclampsia.
Lehnen
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Frauenklinik, RWTH Aachen.
el Magd
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Schöngen
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Reinecke
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D000328:Adult; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis*; D007231:Infant, Newborn; D010927:Placental Insufficiency / Q000097:blood / Q000175:diagnosis*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D012016:Reference Values; D012189:Retrospective Studies
D005353:Fibronectins
Kritische Würdigung von Fibronektin bei schwangerschaftsinduzierter Hypertonie (SIH)/Prëklampsie (PE) und Plazentainsuffizienz (PI).