title: Repeat cerebral blood volume assessment with first-pass MR imaging.
abstract: The feasibility of performing multiple first-pass studies with dynamic, contrast material-enhanced magnetic resonance (MR) imaging was evaluated in a cat model of acute middle cerebral artery (MCA) ischemia. Two dynamic series of SSFP (steady-state free precession) images were acquired in each animal (n = 5) with a conventional 1.5-T imager. The initial first-pass study was acquired at 60 minutes after MCA occlusion, and the second study at 70 minutes, with each performed during an intravenous bolus injection of a 0.5 mmol/kg dose of gadoteridol. In both first-pass studies, differentiation of normal and ischemic gray and white matter was highly statistically significant. At a threshold of P < .01, no statistically significant difference in the peak signal intensity between the first and second studies was noted. A difference between the two studies in the recovery to baseline was seen, presumably due to T1 effects. First-pass MR studies can be repeated within the time frame of a single clinical examination, expanding their utility.
authors.affiliation: Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington 40536-0098.
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: J E
authors.initials: JE
authors.lastname: Kirsch
authors.forename: J W
authors.initials: JW
authors.lastname: Wells
authors.forename: J N
authors.initials: JN
authors.lastname: Dunworth
authors.forename: L
authors.initials: L
authors.lastname: Hilaire
authors.forename: C E
authors.initials: CE
authors.lastname: Woolfolk
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media / Q000008:administration & dosage; D005240:Feasibility Studies; D005682:Gadolinium; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000008:administration & dosage; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium