Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds.
We have previously reported that multidrug (MDR)-reversal activity can be exerted by compounds in which two ring structures of certain types are connected by one alkyl bridge to a secondary or tertiary amine group. In the present investigation we studied the MDR-reversal activity of compounds in which the two ring structures were connected by separate alkyl bridges to the amine group. The structure-activity relationship of these compounds verified previous findings on the structural features that support MDR-reversal activity as well as the features that reduce such activity. In addition, the present study reveals additional chemical groups and ring structures that support MDR-reversal activity as well as those that reduce it.
Ramu
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Department of Oncology, Hadassah University Hospital, Kiryt Hadassah, Jerusalem, Israel.
Ramu
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D000814:Aniline Compounds / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D004351:Drug Resistance; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010640:Phenothiazines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000814:Aniline Compounds; D010640:Phenothiazines