title: Stability and proton-permeability of liposomes composed of archaeal tetraether lipids.
abstract: Liposomes composed of tetraether lipids originating from the thermoacidophilic archaeon Sulfolobus acidocaldarius were analyzed for their stability and proton permeability from 20 degrees C up to 80 degrees C. At room temperature, these liposomes are considerably more stable and have a much lower proton permeability than liposomes composed of diester lipids originating from the mesophilic bacterium Escherichia coli or the thermophilic bacterium Bacillus stearothermophilus. With increasing temperature, the stability decreased and the proton permeability increased for all liposomes. Liposomes composed from tetraether lipids, however, remain the most stable. These data suggest these liposomes retain the rigidity of the cytoplasmic membrane of S. acidocaldarius needed to endure extreme environmental growth conditions.
authors.affiliation: Department of Microbiology, University of Groningen, Haren, The Netherlands.
authors.forename: M G
authors.initials: MG
authors.lastname: Elferink
authors.forename: J G
authors.initials: JG
authors.lastname: de Wit
authors.forename: A J
authors.initials: AJ
authors.lastname: Driessen
authors.forename: W N
authors.initials: WN
authors.lastname: Konings
mesh_terms: D004355:Drug Stability; D004987:Ethers / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D011522:Protons; D016942:Sulfolobales / Q000737:chemistry*; D013696:Temperature
chemical_list: D004987:Ethers; D008055:Lipids; D008081:Liposomes; D011522:Protons