[CT and MRT in progressive multifocal leukoencephalopathy (PML)].
Radiological findings and course of progressive multifocal leukoencephalopathy in 14 patients (1 woman, 13 men; 13 HIV seropositive, 1 chronic lymphatic leukaemia) were analysed retrospectively and correlated with clinical symptoms. A total of 21 CT and 16 MRI studies were evaluated. CT scans and MR images of 9 patients, which had been obtained in less than two weeks, could be compared to each other. MRI was superior to CT: 6 lesions with a diameter of 1 cm and below were not detected on CT scans, in 5 patients the extent of lesions was underestimated. Cortical involvement, mass effect or signs of atrophy were missing. Only 1 of 67 lesions showed a tiny enhancement after Gd injection. Due to the pattern and spread of lesions, which showed a close correlation to the neurologic symptoms, three different types of PML are suggested: 1. initial precentral demyelinisation with contralateral hemiparesis (n = 8); 2. lesions in temporo-occipital locations with visual disturbances (n = 2); 3. predominantly bilateral lesions of cerebellar white matter with ataxia (n = 4).
Lanfermann
H
H
Institut und Poliklinik für Radiologische Diagnostik, Universität zu Köln.
Heindel
W
W
Schröder
R
R
Lackner
K
K
D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D005260:Female; D006679:HIV Seropositivity / Q000150:complications; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed
CT und MRT der progressiven multifokalen Leukenzephalopathie (PML).