Controlled release of theophylline monohydrate from amylodextrin tablets: in vitro observations.
Amylodextrin is a linear dextrin and can be produced by enzymatic hydrolysis of the alpha-1,6 glycosidic bonds of amylopectin. Tablets compacted from pure amylodextrin showed good binding properties and did not disintegrate in aqueous media. Extended and decreasing drug release rates were found for tablets of 300 mg with a diameter of 9 mm containing 70% amylodextrin and 30% theophylline monohydrate, when compacted at 5 kN. Almost-constant drug release rates were obtained for these tablets when compacted at 10 or 15 kN. Nearly constant drug release rates were also shown for amylodextrin tablets with a drug load up to 75% compacted at 10 kN. Both release rate and release profile could be adjusted by selecting tablet thickness and incorporation of either lactose as a highly soluble excipient or talc as a hydrophobic excipient.
Van der Veen
J
J
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands.
Te Wierik
G H
GH
Van der Wal
L
L
Eissens
A C
AC
Lerk
C F
CF
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D003912:Dextrins / Q000737:chemistry*; D005079:Excipients; D016062:Porosity; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D003912:Dextrins; D005079:Excipients; D013607:Tablets; C010026:amylodextrins; D013806:Theophylline