[Oxygen transport properties of the blood in acute nitrite methemoglobinemia].
Studies showed that a single injection of 5 mg/100 g of sodium nitrite causes the development of marked hemic hypoxia in rats, which is characterized by considerable increase of methemoglobin concentration, reduction of O2 content and O2 tension in arterial blood, sharp fall of the intensity of O2 consumption, decrease of methemoglobin concentration, and increase of the content of 2,3-diphosphoglycerate in the red cells. This is evidence of disturbed blood oxygen-transport function and the development of compensatory mechanisms directed at improving O2 supply to the tissues.
Volzhskaia
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AM
Popova
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NI
Sladkova
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SV
D000208:Acute Disease; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D008708:Methemoglobinemia / Q000097:blood* / Q000139:chemically induced; D010100:Oxygen / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite
D012977:Sodium Nitrite; D010100:Oxygen
Kislorodtransportnye svoĭstvia krovi pri ostroĭ nitritnoĭ metgemoglobinemii.