title: Escins-Ia, Ib, IIa, IIb, and IIIa, bioactive triterpene oligoglycosides from the seeds of Aesculus hippocastanum L.: their inhibitory effects on ethanol absorption and hypoglycemic activity on glucose tolerance test.
abstract: Five triterpene oligoglycosides named escins-Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of Aesculus hippocastanum L. and their chemical structures were determined on the basis of chemical and physicochemical evidence. Escins-Ia, Ib, IIa, and IIb were found to exhibit inhibitory effect on ethanol absorption and hypoglycemic activity on oral glucose tolerance test in rats. Among them, escins-IIa and IIb showed the higher activities for both bioassays, while desacylescins-I and II had no activity.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: E
authors.initials: E
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Wariishi
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: I
authors.initials: I
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D004928:Escin / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D000431:Ethanol / Q000493:pharmacokinetics*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D014315:Triterpenes; D000431:Ethanol; D004928:Escin