title: Laboratory variables of bladder autoaugmentation in an animal model.
abstract: OBJECTIVE
  Evaluations of the functional, radiologic, and pathologic outcomes of autoaugmentation by two surgical techniques (vesicomyectomy versus vesicomyotomy) were compared. Autoaugmentation or vesicomyotomy is being increasingly considered as a simplified method of bladder augmentation in the hypertonic decreased-capacity bladder.
  
  
  METHODS
  In a series of 35 laboratory sessions, creation of an animal model approximating the small-capacity hypertonic bladder was achieved. Sixteen vesicomyotomies and 16 vesicomyectomies were performed on the 32 stabilized one-third reduced bladders. Three stabilized one-third reduced bladders were used as controls.
  
  
  RESULTS
  Radiologic studies show a large diverticulum. A 17.2% net increase in surface area was achieved, compared with the reduced bladder, at the time of pathologic examination. Functional capacity was increased by 43.5% on urodynamic studies, and leak point pressure was decreased by 48.1%. Histologic and morphometric examinations of the autoaugmentation area showed a few muscle fibers with serosal deposition of collagen. There was less muscle ingrowth at the periphery of the autoaugmentation site utilizing vesicomyectomy.
  
  
  CONCLUSIONS
  There was no statistical difference between vesicomyotomy and vesicomyectomy with respect to radiologic, pathologic, or urodynamic outcome.
authors.affiliation: British Columbia's Children's Hospital, Vancouver, Canada.
authors.forename: H W
authors.initials: HW
authors.lastname: Johnson
authors.forename: M K
authors.initials: MK
authors.lastname: Nigro
authors.forename: L
authors.initials: L
authors.lastname: Stothers
authors.forename: H
authors.initials: H
authors.lastname: Tearle
authors.forename: W J
authors.initials: WJ
authors.lastname: Arnold
mesh_terms: D000818:Animals; D008954:Models, Biological; D011817:Rabbits; D011859:Radiography; D011897:Random Allocation; D013514:Surgical Procedures, Operative / Q000379:methods; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*