[Mechanism of the cytologic action of streptolysin O: effect of scavengers of active oxygen species and complexons on erythrocyte hemolysis].
The hemolysis of rabbit erythrocytes, initiated by streptolysin O purified samples, is appreciably suppressed in the presence of the scavengers of singlet oxygen (sodium azide, histidine, tryptophan), .OH-radical (ethanol, mannitol), O.(2-)-radical (nitrotetrazolium blue, streptokinase), chelating agents (o-phenanthroline, sodium diethyldithiocarbamate) and some oxidoreductants such as K3FeCN6 and riboflavin as well. The streptolysin O hemolytic effect is supposed to be realized due to the participation of active oxygen species and this phenomenon depends upon the presence of the transition metals in the system.
Nikandrov
V N
VN
Lapushkina
T N
TN
D000818:Animals; D001426:Bacterial Proteins; D002470:Cell Survival / Q000187:drug effects; D002614:Chelating Agents / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D016166:Free Radical Scavengers; D006461:Hemolysis / Q000187:drug effects*; D017665:Hydroxyl Radical; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000494:pharmacology*; D013301:Streptolysins / Q000494:pharmacology*; D013481:Superoxides
D001426:Bacterial Proteins; D002614:Chelating Agents; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D013301:Streptolysins; C025964:streptolysin O; D013481:Superoxides; D017665:Hydroxyl Radical
Mekhanizm tsitoliticheskogo deĭstviia streptolizina O: vliianie perekhvatchikov aktivnykh form kisloroda i kompleksonov na gemoliz éritrotsitov.