title: Cyclophosphamide, cisplatin, and leuprolide acetate in patients with debulked stage III or IV ovarian carcinoma.
abstract: A phase II study of cyclophosphamide, cisplatin, and leuprolide acetate after debulking of stage III or IV ovarian carcinoma was conducted in 33 patients through a cooperative group study involving 11 institutions. The intent was to determine whether the addition of a gonadotropin-releasing hormone analogue would alter the response rates and toxicity profile of cyclophosphamide and cisplatin in patients with advanced ovarian cancer. Twenty-nine patients completed all 6 planned cycles. Of the 19 patients who had second-look laparotomy, 12 had persistent disease and 7 were negative for disease. The use of a gonadotropin-releasing hormone with combined chemotherapy did not alter the toxicity profile or the effectiveness of chemotherapy when comparisons were made with historical controls.
authors.affiliation: Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: L D
authors.initials: LD
authors.lastname: Erickson
authors.forename: L C
authors.initials: LC
authors.lastname: Hartmann
authors.forename: J Q
authors.initials: JQ
authors.lastname: Su
authors.forename: S N
authors.initials: SN
authors.lastname: Nielsen
authors.forename: D M
authors.initials: DM
authors.lastname: Pfeifel
authors.forename: R M
authors.initials: RM
authors.lastname: Goldberg
authors.forename: R
authors.initials: R
authors.lastname: Levitt
authors.forename: C R
authors.initials: CR
authors.lastname: Stanhope
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007813:Laparotomy; D016729:Leuprolide / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003520:Cyclophosphamide; D005640:Follicle Stimulating Hormone; D016729:Leuprolide; D002945:Cisplatin