title: Hyperthermia-associated changes in Fos protein in the median preoptic and other hypothalamic nuclei of the pig following intravenous administration of prostaglandin E2.
abstract: Changes in body temperature and hypothalamic Fos production were investigated in pigs injected intravenously with prostaglandin E2 (PGE2, 20 micrograms/kg). PGE2 produced a sustained (> 150 min) hyperthermia (0.7-1 degree C) and significant increases in Fos labelling in the supraoptic and paraventricular nuclei. In addition, PGE2 induced Fos production in the median preoptic nucleus, a region previously demonstrated to be involved in thermoregulation in this species.
authors.affiliation: Department of Neurobiology, AFRC Babraham Institute, Cambridge, UK.
authors.forename: S V
authors.initials: SV
authors.lastname: Vellucci
authors.forename: R F
authors.initials: RF
authors.lastname: Parrott
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology*; D005334:Fever / Q000378:metabolism*; D007275:Injections, Intravenous; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D011301:Preoptic Area / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D013552:Swine
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D015232:Dinoprostone