Enhancement of gastric mucosal blood flow with sulglycotide.
Twelve patients with dyspepsia whose gastric abnormalities ranged from diffuse reddening of the mucosa to multiple erosions were treated for 4 weeks with oral sulglycotide, a sulphated glycopeptide with known gastroprotective and ulcer-healing properties. Before and after treatment, gastric mucosal blood flow was assessed by means of laser Doppler flowmetry. A significant (P < 0.01) increase in mucosal perfusion was observed after sulglycotide treatment, suggesting that enhancement of mucosal blood flow may contribute to the therapeutic properties of the drug.
Guslandi
M
M
Gastroenterology Unit, San Raffael Hospital, University of Milan, Italy.
Sorghi
M
M
Tittobello
A
A
D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology; D005773:Gastroscopy; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D012795:Sialoglycoproteins / Q000494:pharmacology / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D012795:Sialoglycoproteins; C009354:sulglicotide