[The gamma delta T-cell receptors in sarcoidosis].
T-cells recognize specific antigen (s) through the T-cell antigen receptors (TCR). gamma delta T-cells compose a minor population of the peripheral blood lymphocytes (PBL). These lymphocytes play a central role in recognizing the mycobacterial antigens and granuloma formation in tuberculosis and leprosy. Significant increase of gamma delta T-cells in PBL is observed in a subgroup of sarcoidosis. The majority of gamma delta T-cells showed V gamma 9/V delta 2 recombination, which is common in normal blood. To evaluate the clonality of the increased gamma delta T-cells in PBL, several V gamma 9 and V delta 2 cDNA clones were established. Analysis of V-J junctional sequences of V gamma 9 clones revealed oligoclonal expansion in some cases. Most of V delta 2 clones showed unique sequences. Although no clonal expansion of gamma delta T-cells were observed, TCR-gamma chain might recognize limited numbers of putative antigens in sarcoidosis.
Tamura
N
N
Department of Respiratory Medicine, Juntendo University School of Medicine.
Suzuki
K
K
Yamamoto
T
T
Kira
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000737:chemistry* / Q000235:genetics; D012507:Sarcoidosis / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes
D016692:Receptors, Antigen, T-Cell, gamma-delta