Thyroid hormone metabolism. A comparative evaluation.
Knowledge of thyroid hormone and iodide metabolism is derived from a combination of in vivo and in vitro studies in a variety of mammalian species including cats, dogs, and humans. Each species provides a unique opportunity to investigate various aspects of normal or altered thyroid hormone physiology. Availability of sensitive and specific human TSH assays has allowed detailed studies of the human hypothalamic-pituitary-thyroid axis which have not been possible in cats and dogs to date. Similarities and differences of thyroid hormone metabolism in dogs, cats, and humans provide the basis for a better understanding of normal physiology as well as shedding light on the significance of changes induced by spontaneous or induced thyroidal and nonthyroidal disorders.
Kaptein
E M
EM
Department of Medicine, University of Southern California, Los Angeles.
Hays
M T
MT
Ferguson
D C
DC
D000818:Animals; D000829:Animals, Domestic / Q000378:metabolism; D000830:Animals, Laboratory / Q000378:metabolism; D002415:Cats / Q000378:metabolism*; D004285:Dogs / Q000378:metabolism*; D006801:Humans; D007454:Iodides / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D013045:Species Specificity; D013959:Thyroid Diseases / Q000378:metabolism / Q000662:veterinary; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*
D007454:Iodides; D013963:Thyroid Hormones