The myb oncogene family of transcription factors: potent regulators of hematopoietic cell proliferation and differentiation.
The myb family of genes includes the virally encoded v-myb oncogene, the c-myb protooncogene from which it is derived, and two structurally related genes, B-myb and A-myb. C-myb is most highly expressed in hematopoietic cells and its oncogenic activation leads to transformation, primarily of myeloid cells. Several lines of evidence suggest that c-myb functions in regulating both the proliferation and differentiation of hematopoietic cells of different lineages, including early progenitors. The mechanisms of action and the regulation of expression of c-myb and v-myb will be described. The possible role of the B-myb and A-myb gene products will also be discussed.
Introna
M
M
Unit of Molecular Differentiation, Istituto Ricerche Farmacologiche Mario Negri, Milano, Italy.
Luchetti
M
M
Castellano
M
M
Arsura
M
M
Golay
J
J
D001483:Base Sequence; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009857:Oncogenes; D014157:Transcription Factors / Q000235:genetics*
D014157:Transcription Factors