Tn924, a chromosome-borne transposon encoding high-level gentamicin resistance in Enterococcus faecalis.
Enterococcus faecalis SF350 is a clinical isolate from Winnipeg, Canada, with high-level (MIC > 2,000 micrograms/ml) gentamicin resistance. The genetic determinant for gentamicin resistance was located on the chromosome of SF350 and could be mobilized by a coresident conjugative plasmid, pYN120. Genetic and physical analyses showed that the gentamicin resistance determinant was located on a 27-kb transposable element which was designated Tn924.
Thal
L A
LA
Department of Medicine, William Beaumont Hospital, Royal Oak, MI 48073.
Chow
J W
JW
Clewell
D B
DB
Zervos
M J
MJ
D002876:Chromosomes, Bacterial / Q000502:physiology*; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects / Q000235:genetics* / Q000648:ultrastructure; D005839:Gentamicins / Q000494:pharmacology*; D010957:Plasmids; D015183:Restriction Mapping
D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005839:Gentamicins