RNA editing in mitochondria of cultured trypanosomatids: translatable mRNAs for NADH-dehydrogenase subunits are missing.
RNA editing in mitochondria of kinetoplastid protozoa involves the posttranscriptional insertion and deletion of uridylate residues in protein encoding regions of pre-mRNAs. Editing is required to remove gene-encoded translational defects or to convert a nonsense sequence into a sense message. In cultured trypanosomatids, however, translationally defective pre-mRNAs for a number of NADH-dehydrogenase subunits are not converted into functional mRNAs by editing. In this report, the available data are discussed in the context of current models for RNA editing.
Sloof
P
P
E. C. Slater Institute, Biocentre Amsterdam, Academic Medical Centre, The Netherlands.
Arts
G J
GJ
van den Burg
J
J
van der Spek
H
H
Benne
R
R
D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000235:genetics*; D017393:RNA Editing / Q000235:genetics; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016053:RNA, Protozoan / Q000235:genetics / Q000378:metabolism; D014351:Trypanosomatina / Q000235:genetics* / Q000378:metabolism*
D018076:DNA, Complementary; D004272:DNA, Mitochondrial; D016054:DNA, Protozoan; D012322:RNA Precursors; D012333:RNA, Messenger; D016053:RNA, Protozoan; D009245:NADH Dehydrogenase