title: Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging--parametric "first-pass" images depict tissue vascularization and perfusion.
abstract: OBJECTIVE
  To assess the diagnostic value of parametric magnetic resonance images that display the first pass (FP) of gadopentetate dimeglumine.
  
  
  METHODS
  Dynamic, contrast material-enhanced, fast low-angle shot MR imaging was performed of 100 musculoskeletal lesions in 36 female and 64 male patients (aged 9-81 years [mean, 34 years]). The highest slope value of the time-intensity curve was calculated pixel by pixel and displayed on the FP image, with a gray-scale value equal to the slope value. Tissue vascularization and perfusion were evaluated at pathologic and angiographic examinations in 33 lesions.
  
  
  RESULTS
  A significant difference (P < .001) was found between the FP slope values of benign (mean, 36.2% per second) and malignant (mean, 67.4% per second) lesions. FP images depicted tissue vascularization and perfusion rather than benignity or malignancy, because there is an overlap in the slope values of highly vascular benign lesions and malignant lesions.
  
  
  CONCLUSIONS
  FP images provide diagnostically useful information by depicting tissue vascularization and perfusion.
authors.affiliation: Department of Radiology, Gent University Hospital, Belgium.
authors.forename: K L
authors.initials: KL
authors.lastname: Verstraete
authors.forename: Y
authors.initials: Y
authors.lastname: De Deene
authors.forename: H
authors.initials: H
authors.lastname: Roels
authors.forename: A
authors.initials: A
authors.lastname: Dierick
authors.forename: D
authors.initials: D
authors.lastname: Uyttendaele
authors.forename: M
authors.initials: M
authors.lastname: Kunnen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001847:Bone Diseases / Q000175:diagnosis*; D001859:Bone Neoplasms / Q000098:blood supply / Q000175:diagnosis; D001842:Bone and Bones / Q000098:blood supply; D002648:Child; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply; D009135:Muscular Diseases / Q000175:diagnosis*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000175:diagnosis
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA