title: Cyclosporin A treatment failed to extend skin allograft survival in two burn patients.
abstract: Prolongation of skin allograft survival by immunosuppression of burn casualties has been reported sporadically during the past two decades. Recently cyclosporin A (CycA) has been used effectively for such an indication. We report here two paediatric patients with extensive burns (85-95 per cent BSA) treated with fresh, family-related skin allografts that were rejected during CycA treatment after 14-18 days. One of these children survived while the other died with candida sepsis.
authors.affiliation: Burn Unit, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Eldad
authors.forename: P
authors.initials: P
authors.lastname: Benmeir
authors.forename: A
authors.initials: A
authors.lastname: Weinberg
authors.forename: A
authors.initials: A
authors.lastname: Neuman
authors.forename: M
authors.initials: M
authors.lastname: Chaouat
authors.forename: H
authors.initials: H
authors.lastname: Ben-Bassat
authors.forename: M R
authors.initials: MR
authors.lastname: Wexler
mesh_terms: D002056:Burns / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D008297:Male; D016038:Skin Transplantation; D014184:Transplantation, Homologous
chemical_list: D016572:Cyclosporine