[Safety and tolerance of a new dipeptide-containing amino acid solution DP-Gln 20 versus a conventional amino acid solution Vamin 18EF in patients after elective colon surgery].
OBJECTIVE
Recent studies have demonstrated the important role of glutamine in postoperative metabolism. Using dipeptide-containing amino acid solutions it is possible to enhance glutamine supply. Safety and tolerance of DP-Gln 20 (gly-gln, gly-tyr) and Vamin 18EF were investigated in an open, prospective, randomised study. 16 patients received isonitrogenous parenteral nutrition over 4 days.


RESULTS
There was no difference in clinical and biochemical patterns between both groups. Complications and adverse events due to the infused amino acid solutions were not observed.
Goeters
C
C
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin der WWU Münster.
Mertes
N
N
Kuhmann
M
M
Lange
V
V
Dietl
K H
KH
Lawin
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D003082:Colectomy; D003110:Colonic Neoplasms / Q000601:surgery*; D004151:Dipeptides / Q000008:administration & dosage*; D004573:Electrolytes; D005260:Female; D005947:Glucose; D006801:Humans; D008297:Male; D008875:Middle Aged; D057947:Parenteral Nutrition Solutions; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D011446:Prospective Studies; D012996:Solutions
D000596:Amino Acids; D004151:Dipeptides; D004573:Electrolytes; D057947:Parenteral Nutrition Solutions; D012996:Solutions; C545824:amino-acid, glucose, and electrolyte solution; C039788:glycylglutamine; C022013:glycyltyrosine; D005947:Glucose
Sicherheit und Verträglichkeit der neuen dipeptidhaltigen Aminosäurelösung DP-Gln 20 versus einer konventionellen Aminosäurelösung Vamin 18EF bei Patienten nach elektiver Kolonchirurgie.