Cell kinetics and radiosensitivity of cervical squamous cell carcinoma.
Flow cytometry analyses of tumors from 12 patients with cervical squamous cell carcinoma under radiotherapy were performed in this preliminary study. Six patients with a high (> 10%) G2/M fraction before treatment showed greater than 50% tumor reduction after initial 2000 cGy radiotherapy. Only two out of six patients with a low (< 10%) G2/M fraction before treatment responded favorably and three of them already had recurrence during the follow-up period of 33-40 months. Hyperploidy (DNA index > 1.1) was observed in 5 patients; all of them responded well to radiotherapy in contrast to three out of seven diploid tumors.
Chen
C A
CA
Department of Obstetrics and Gynecology, National Taiwan University, College of Medicine, Taipei.
Wu
C C
CC
Chen
T M
TM
Lui
L T
LT
Chang
C F
CF
Hsieh
C Y
CY
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy*; D005260:Female; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D008938:Mitosis; D008940:Mitotic Index; D011003:Ploidies; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy*