The growth of hemopoietic stem cells is inhibited by natural killers only in the nonsyngeneic microenvironment.
The growth of hemopoietic cells of some inbred animal lines is repressed in hybrids of the first generation (F1)--the phenomenon of hybrid resistance. We have investigated the mechanism of hybrid resistance by studying the growth of hemopoietic cells of C57BL/6 mice in syngeneic and semisyngeneic heterotopic hemopoietic foci formed under the kidney capsule in (CBA*C57BL/6)F1 recipient mice. We found that hybrid resistance depended upon the joint involvement of NK cells and semisyngeneic hemopoietic stroma. It is concluded that NK cells recognize antigenic markers appearing on target cells located in a nonsyngeneic microenvironment.
Pirozhkov
A V
AV
Schemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Dozmorov
I M
IM
Petrov
R V
RV
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology; D006084:Graft Rejection; D006128:Growth; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006824:Hybridization, Genetic; D007668:Kidney; D007694:Killer Cells, Natural / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016042:Transplantation, Heterotopic