title: [Widespread argentophilic structures in progressive supranuclear palsy--an autopsy case report].
abstract: We report an autopsy case of progressive supranuclear palsy (PSP) with a five-year clinical course. A 67-year-old man was suffering from a gait disturbance and mental deterioration. Neurological examination at the age of 71 revealed pseudobulbar palsy, horizontal ophthalmoplegia, and truncal dystonia, and a diagnosis of PSP was made. Mental deterioration including forgetfulness and character change was also noted, and the patient sometimes exhibited intermittent stuporous states. Cranial computed tomography and magnetic resonance images revealed moderate brain atrophy, predominantly in the frontal lobes. The patient died of bronchopneumonia at the age of 71. Neuropathological examination confirmed typical pathological changes of PSP, such as neuronal loss, neurofibrillary tangles, and fibrillary gliosis in the subcortical nuclei. Gallyas-Braak silver impregnation revealed neurofibrillary tangles, silver-positive glia and thread-like structures in degenerating subcortical nuclei. In addition to these classical lesions, the argentophilic structures were detected in the cerebral cortex, cortical white matter and cerebellar white matter. In the cerebral cortex, they were abundant mostly in the precentral gyrus and subcortical white matter. Immunohistochemical studies revealed that most silver-positive structures were also tau 2 antibody-positive. Thus, these argentophilic structures seemed to be closely related to abnormal tau protein. Their distribution in this case implies that lesions related to abnormal tau protein may occur more extensively in the brains of PSP than expected.
authors.affiliation: Division of Psychiatry, Kanagawa Rehabilitation Center, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hanihara
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: N
authors.initials: N
authors.lastname: Amano
authors.forename: K
authors.initials: K
authors.lastname: Yamaoka
authors.forename: S
authors.initials: S
authors.lastname: Yagishita
mesh_terms: D000368:Aged; D002531:Cerebellum / Q000737:chemistry / Q000473:pathology; D002540:Cerebral Cortex / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D016622:Silver Staining; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis
chemical_list: D016875:tau Proteins