[Mechanisms of the stimulating effect of d-glucuronic acid on the processes of bone marrow granulomonocytopoiesis in cytostatic myelodepression].
The mechanisms of regulating influence of D-glucuronic acid on granulomonocytopoiesis++ have been studied by using the model of cyclophosphamide-induced myelodepression. Increase of colony-stimulating and interleukin-1 activities production by hemopoiesis inducing microenvironment cells, the stimulation of hemopoietic islets and the different granulomonocytopoiesis precursor cells forming have been shown to be the base of activating action of D-glucuronic acid on bone marrow granulomonocytopoiesis recovery.
Gol'dberg
E D
ED
Dygaĭ
A M
AM
Karpova
G V
GV
Simanina
E V
EV
Khlusov
I A
IA
Shakhov
V P
VP
Agafonov
V I
VI
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D005965:Glucuronates / Q000494:pharmacology*; D020723:Glucuronic Acid; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007375:Interleukin-1 / Q000096:biosynthesis; D051379:Mice; D008808:Mice, Inbred CBA; D009000:Monocytes / Q000187:drug effects*; D013237:Stereoisomerism
D005965:Glucuronates; D007375:Interleukin-1; D020723:Glucuronic Acid; D003520:Cyclophosphamide
O mekhanismakh stimuliruiushchego vliianie d-gliukuronovoĭ kisloty na protsessy kostnomozgovogo granulomonotsitopoéza v usloviiakh tsitostaticheskoĭ mielodepressii.