[The effect of neurotropic agents on lipid peroxidation in the heart and stomach with neurogenic lesions].
Neurogenic gastric lesions in rats were induced by a combination of immobilization and 3-hour electrostimulation. Neurogenic cardiac injury in rabbits were induced by 3-hour electrical stimulation of the aortic arch. Thereafter the activation of lipid peroxidation in the stomach and heart was recorded. There was an increase in MDA levels and a decrease in antioxidative enzyme activity in the tissues and serum (catalase and superoxide dismutase). The administration of the neurotropic drugs which restore the activity of the sympathetic nervous system (L-DOPA, aethimizol, fenibut and piracetam) was shown to normalize the processes of lipid peroxidation.
Bul'on
V V
VV
Zavodskaia
I S
IS
Khnychenko
L K
LK
D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005042:Etimizol / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D007980:Levodopa / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010889:Piracetam / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D013270:Stomach / Q000187:drug effects*; D013272:Stomach Diseases / Q000188:drug therapy* / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014149:Tranquilizing Agents / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
D014149:Tranquilizing Agents; D007980:Levodopa; D005680:gamma-Aminobutyric Acid; D005042:Etimizol; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam
Vliianie nekotorykh neĭrotropnykh sredstv na perekisnoe okislenie lipidov v serdtse i zheludke pri ikh neĭrogennom povrezhdenii.