1,2,3-Triazole[4,5-d]pyridazines--II. New derivatives tested on adenosine receptors.
This paper reports the synthesis and biological evaluation towards A1 and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.
Biagi
G
G
Istituto di Chimica Farmaceutica e Tossicologica, Università di Pisa.
Giorgi
I
I
Livi
O
O
Scartoni
V
V
Martini
C
C
Tacchi
P
P
Merlino
S
S
Pasero
M
M
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D002849:Chromatography, Gas; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D017072:Neostriatum / Q000378:metabolism; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000187:drug effects*; D012756:Sheep
D011724:Pyridazines; D018047:Receptors, Purinergic P1