Liposomal amphotericin B in hepatic candidosis.
A 4 year old girl treated with a standard chemotherapy protocol for acute lymphoblastic leukaemia developed hepatic candidosis during the consolidation phase. This relapsed after a prolonged course of amphotericin B and flucytosine. An eight week course of liposomal amphotericin produced a marked clinical improvement which was sustained for one year. A subsequent relapse was associated with transformation to myelodysplastic leukaemia.
Sharland
M
M
Department of Child Health, St George's Hospital Medical School, London.
Hay
R J
RJ
Davies
E G
EG
D000666:Amphotericin B / Q000627:therapeutic use*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008081:Liposomes; D008099:Liver / Q000382:microbiology; D008107:Liver Diseases / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications
D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B