title: Temporal changes in neuro-immuno endocrine system with adjuvant radiotherapy for advanced rectal cancer.
abstract: The purpose of this study was to evaluate the effect of adjuvant radiotherapy for advanced rectal cancers on the human neuro-immuno-endocrine system. Fifty-seven patients with rectal cancer were investigated. Abdominoperineal resection (APR) was carried out on all of them. The levels of serum IAP in 4-12 weeks after operation were significantly higher in the preoperative radiotherapy group compared with those of non-preoperatively irradiated (p < 0.05). With preoperative radiotherapy, serum IAP levels in patients with postoperative intracavitary cone irradiation returned to normal values within three months of operation; however, those with postoperative external pelvic irradiation continued to be significantly elevated until six months after operation. We conclude that preoperative radiotherapy combined with post-operative external pelvic irradiation is likely to exert unfavorable effects on the human immuno-endocrine system.
authors.affiliation: First Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takenoshita
authors.forename: T
authors.initials: T
authors.lastname: Hashizume
authors.forename: T
authors.initials: T
authors.lastname: Asao
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Katoh
authors.forename: H
authors.initials: H
authors.lastname: Koitabashi
authors.forename: H
authors.initials: H
authors.lastname: Niibe
authors.forename: N
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yamakawa
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D004837:Epinephrine / Q000097:blood; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D009363:Neoplasm Proteins / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000276:immunology / Q000503:physiopathology / Q000532:radiotherapy*; D012189:Retrospective Studies
chemical_list: D006023:Glycoproteins; D007375:Interleukin-1; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein; C038588:serum immunosuppressive factor, human; D000324:Adrenocorticotropic Hormone; D009638:Norepinephrine; D004837:Epinephrine