title: Nephrogenic diabetes insipidus associated with bilateral ureteral obstruction.
abstract: Nephrogenic diabetes insipidus associated with ureteral obstruction is rare. We report a case of nephrogenic diabetes insipidus associated with ureteral obstruction caused by ileal leiomyosarcoma in a 32-year-old man. The treatment with trichlorothiazide and diclofenac sodium reduced urine output from 8 L/day to 4 L/day. Six months after nephrostomy, urine output decreased to 2.5 L/day without any drug administration. This case suggests that ureteral obstruction may cause an increase in urine output to 8 L/day and that surgical treatment for ureteral obstruction is effective in reducing urine output in nephrogenic diabetes insipidus patients with ureteral obstruction.
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: A
authors.initials: A
authors.lastname: Hishida
authors.forename: R
authors.initials: R
authors.lastname: Ishibashi
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: M
authors.initials: M
authors.lastname: Ohura
authors.forename: R
authors.initials: R
authors.lastname: Furuya
authors.forename: H
authors.initials: H
authors.lastname: Kumagai
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: E
authors.initials: E
authors.lastname: Kaneko
mesh_terms: D000328:Adult; D002740:Chlorothiazide / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000150:complications* / Q000188:drug therapy; D004008:Diclofenac / Q000627:therapeutic use; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy; D007890:Leiomyosarcoma / Q000150:complications; D008297:Male; D011141:Polyuria / Q000150:complications / Q000188:drug therapy; D014517:Ureteral Obstruction / Q000150:complications* / Q000209:etiology / Q000601:surgery
chemical_list: D004008:Diclofenac; D002740:Chlorothiazide