title: Ventricular function during liver reperfusion in hepatic transplantation. A transesophageal echocardiographic study.
abstract: Postreperfusion syndrome (PRS) is the most dramatic and acute hemodynamic alteration that occurs in OLT. Our aim was to determine heart function by hemodynamic monitoring and transesophageal echocardiography during PRS. We studied 24 nonconsecutive patients allocated to 2 groups: group A (n = 8), patients with PRS, and group B (n = 16), patients without PRS. Usual hemodynamic data were obtained simultaneously with transesophageal echocardiography recording of the left ventricular imaging in 4 different stages: after induction of anesthesia, 5 min before the end of the anhepatic phase, between 2 and 5 min after reperfusion, and 5 min after graft reperfusion. The hemodynamic and echocardiographic findings during reperfusion were (group A vs. group B patients): mean arterial pressure, 50.0 +/- 15.2 vs. 74.7 +/- 13.9 mmHg (P < 0.01); pulmonary capillary wedge pressure, 12.7 +/- 6.1 vs. 13.9 +/- 5.7 mmHg (NS); left ventricular ejection fraction, 79.6 +/- 9.3 vs. 83.4 +/- 9.4% (NS); left ventricular end diastolic volume index, 35.5 +/- 12.7 vs. 54.7 +/- 21.3 ml/m2 (P < 0.05); and stroke volume index, 27.9 +/- 8.9 vs. 45.5 +/- 15.9 ml/m2 (P < 0.01). There was a mild decrease in left ventricular compliance in group A. We found no alteration in left ventricular function that can justify PRS. The hemodynamic changes during PRS seemed to be caused by an insufficient increase in preload after unclamping.
authors.affiliation: Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: G
authors.initials: G
authors.lastname: de la Morena
authors.forename: F
authors.initials: F
authors.lastname: Acosta
authors.forename: M
authors.initials: M
authors.lastname: Villegas
authors.forename: M
authors.initials: M
authors.lastname: Bento
authors.forename: T
authors.initials: T
authors.lastname: Sansano
authors.forename: F S
authors.initials: FS
authors.lastname: Bueno
authors.forename: P
authors.initials: P
authors.lastname: Ramirez
authors.forename: J A
authors.initials: JA
authors.lastname: Ruiperez
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D003971:Diastole; D017548:Echocardiography, Transesophageal; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006439:Hemodynamics; D006801:Humans; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000502:physiology*; D015427:Reperfusion Injury / Q000503:physiopathology*; D013599:Systole; D016276:Ventricular Function / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology