24-hour control of body temperature in rats. I. Integration of behavioral and autonomic effectors.
Some studies suggest that the nocturnal elevation in core temperature (Tc) of the rat is mediated by an elevation in the set point. The role of set point can be assessed if behavioral effectors are measured simultaneously with other thermoregulatory effectors and Tc over a 24-h period. Selected ambient temperature (STa) and motor activity (MA) were measured in rats housed in a temperature gradient system with a 12:12-h photoperiod (lights on 0600 h). Tc and heart rate (HR) were monitored by telemetry. During the light phase, STa, Tc, HR, and MA were relatively stable with values 29.0 degrees C, 37.1 degrees C, 310 beats/min, and 1-2 m/h, respectively. During the light-to-dark transition there were abrupt elevations in Tc, HR, and MA but no change in STa. STa decreased during the dark phase and reached a nadir of 23 degrees C at 0500 h. All variables recovered to basal levels within 3-4 h after the onset of the light phase. Overall, autonomic effectors control the elevation in Tc during the onset of the dark phase while behavioral effectors have little if any role. Behavioral thermoregulation is important in two ways: 1) the selection of cooler Ta values at night to prevent an excess elevation in Tc and 2) a preference for cooler Ta values before the light phase to facilitate the recovery of Tc.
Gordon
C J
CJ
Neurotoxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001522:Behavior, Animal; D001831:Body Temperature; D002940:Circadian Rhythm; D006339:Heart Rate; D008297:Male; D009043:Motor Activity; D051381:Rats; D013686:Telemetry; D013696:Temperature