title: [Effects of cadmium on vitamin D function involved in the regulation of phosphorus-calcium metabolism].
abstract: The role of vitamin D in regulation of phosphoric-calcium metabolism was evaluated in conditions of experimental cadmium intoxication induced by daily dietetic intake (100 micrograms/kg for 8 months) of cadmium in parallel with intake of calcium in diverse amounts. Daily requirements in vitamin D were provided in different groups of animals either with ergocalciferol (D2) or 24,25-dihydroxycholecalciferol (0.25 microgram per animal). The results of the trial suggested that despite regular supply of ergocalciferol, renal damage induced by cadmium intoxication was associated with phosphoric-calcium metabolic derangement which is likely to result from defects in renal synthesis of active vitamin D form. This was confirmed by the fact that the change of ergocalciferol for 24,25-dihydroxycholecalciferol did not produce any noticeable shifts in the phosphoric-calcium metabolism.
authors.forename: N A
authors.initials: NA
authors.lastname: Volkova
authors.forename: I A
authors.initials: IA
authors.lastname: Karpliuk
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002105:Cadmium Poisoning / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004872:Ergocalciferols / Q000008:administration & dosage / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014807:Vitamin D / Q000502:physiology*
chemical_list: D004872:Ergocalciferols; D002104:Cadmium; D014807:Vitamin D; D010758:Phosphorus; D015650:24,25-Dihydroxyvitamin D 3; D002118:Calcium
vernacular_title: Vliianie kadmiia na funktsiiu vitamina D po regulirovaniiu fosforno-kal'tsievogo obmena v éksperimente.