Topical liposome system bearing local anaesthetic lignocaine: preparation and evaluation.
Topical multiple lamellar vesicular liposomes were formulated by using the method reported by Bangham (1968). The liposomes, composed of different lipid and charge-bearing components such as stearylamine or dicetylphosphate, were characterized for average size, size distribution, charge lamellae and drug loading. The negatively charged liposomes showed high drug loading and were incorporated in different topical vehicles, i.e. gels and ointment. These were evaluated for in vitro drug skin permeation profile. The selected formulations were evaluated for in vivo performance using the pinprick method. The results revealed localized and prolonged activity of local anaesthetic contained in liposomes when compared with equivalent conventional topical application.
Sharma
B B
BB
Department of Pharmaceutical Sciences, Dr H. S. Gour Vishwavidyalaya, Sagar, India.
Jain
S K
SK
Vyas
S P
SP
D000287:Administration, Topical; D000328:Adult; D000464:Alginates; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D005260:Female; D005782:Gels; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008081:Liposomes; D009824:Ointments; D010539:Permeability; D012869:Skin Absorption
D000464:Alginates; D004337:Drug Carriers; D005782:Gels; D006603:Hexuronic Acids; D008081:Liposomes; D009824:Ointments; D020723:Glucuronic Acid; D008012:Lidocaine