title: Neutrophil defects as risk factors for periodontal diseases.
abstract: There are several hypotheses proposed for the etiologic mechanisms causing periodontal diseases. These include a paradigm in which all individuals are equally susceptible to one or several pathogenic bacteria; a second paradigm that holds that all bacteria are equally virulent and that host susceptibility determines onset of disease; or a combination of the above. In this review, we analyze the role of neutrophil dysfunction as a risk factor for the onset of periodontitis. Both intrinsic or genetically inherited abnormalities of neutrophils and acquired neutrophil abnormalities are considered. While a large body of data implicates neutrophil dysfunction, either intrinsic or acquired (bacterially or extrinsically induced), as a significant risk factor for the periodontal diseases, clear, prospective, longitudinal epidemiologic studies to evaluate this association remain to be performed.
authors.affiliation: Department of Periodontology, Eastman Dental Center, Rochester, NY.
authors.forename: T C
authors.initials: TC
authors.lastname: Hart
authors.forename: L
authors.initials: L
authors.lastname: Shapira
authors.forename: T E
authors.initials: TE
authors.lastname: Van Dyke
mesh_terms: D018407:Bacterial Physiological Phenomena; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000502:physiology*; D010510:Periodontal Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D010518:Periodontitis / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D012307:Risk Factors
chemical_list: D008070:Lipopolysaccharides