Treatment of organic bipolar mood disorders in Parkinson's disease.
Two patients with long-standing idiopathic Parkinson's disease (PD), without individual or family histories of affective disorders, developed bipolar mood disorders. Both were treated with lithium and clozapine, and one responded favorably. These may be the first reported cases in which mania was treated with clozapine in PD patients.
Kim
E
E
Department of Psychiatry and Human Behavior, Jefferson Medical College, Philadelphia, Pennsylvania.
Zwil
A S
AS
McAllister
T W
TW
Glosser
D S
DS
Stern
M
M
Hurtig
H
H
D001714:Bipolar Disorder / Q000139:chemically induced* / Q000188:drug therapy / Q000523:psychology; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D016651:Lithium Carbonate / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D012008:Recurrence
D016651:Lithium Carbonate; D007980:Levodopa; D003024:Clozapine