title: Eicosapentaenoic acid enhances intracellular free calcium in cultured human endothelial cells.
abstract: Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca2+ concentration ([Ca2+]i) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA-induced increase in [Ca2+]i could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, causing the elevation of [Ca2+]i.
authors.affiliation: Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okuda
authors.forename: M
authors.initials: M
authors.lastname: Ezure
authors.forename: K
authors.initials: K
authors.lastname: Tsukahara
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: M
authors.initials: M
authors.lastname: Mizutani
authors.forename: T
authors.initials: T
authors.lastname: Katori
authors.forename: C
authors.initials: C
authors.lastname: Bannai
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans
chemical_list: D015118:Eicosapentaenoic Acid; D002118:Calcium