Pleuropericarditis in a patient with ulcerative colitis in longstanding 5-aminosalicylic acid therapy.
We report a case of pleuropericarditis in a 23-yr-old woman with ulcerative colitis (UC) treated with 5-aminosalicylic acid (5-ASA). In our case we exclude a possible 5-ASA hypersensitivity in view of the longterm complication free treatment and the successful resolution of the case without withdrawal of 5-ASA. A 5-ASA induced lupus-like syndrome was also ruled out by immunoserological investigations. Infectious and endocrinologic causes of pleuropericarditis were also excluded. In conclusion pleuropericarditis must be considered a systemic complication of inflammatory bowel disease (IBD) if adverse reaction to 5-ASA and sulfasalazine as well as other possible pathogenetic factors have been ruled out.
Iaquinto
G
G
Servizio di Gastroenterologia ed Endoscopia Digestiva, Ospedale Civile San Giuseppe Moscati, Avellino, Italy.
Sorrentini
I
I
Petillo
F E
FE
Berardesca
G
G
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019804:Mesalamine; D010493:Pericarditis / Q000139:chemically induced / Q000209:etiology*; D010998:Pleurisy / Q000139:chemically induced / Q000209:etiology*; D013997:Time Factors
D000636:Aminosalicylic Acids; D019804:Mesalamine