Partial development of the corpus callosum.
OBJECTIVE
To determine whether the MR findings of callosal dysgenesis suggest that the partially formed corpus callosum in humans is the result of arrested growth or delayed continued development.


METHODS
The MR scans of 25 patients with callosal dysgenesis were reviewed to determine whether the observed corpus callosum corresponded to the form and position of a portion of a normal corpus callosum, as suggested by a theory of arrested growth.


RESULTS
In 10 of the 25 cases, the partially formed corpus callosum corresponded to a portion of a normal corpus callosum. In the remaining 15 cases, the partially formed corpus callosum was located posterior to the expected location of a normal genu and inferior to the expected location of a normal body.


CONCLUSIONS
Corpus callosum dysgenesis in humans may be caused by arrested growth in some cases; in other cases it is most likely caused by delayed continued development that attempts to compensate for earlier abnormalities in the evolution of midline structures.
Rubinstein
D
D
University of Colorado Health Sciences Center, Department of Radiology, Denver 80262.
Youngman
V
V
Hise
J H
JH
Damiano
T R
TR
D000015:Abnormalities, Multiple / Q000175:diagnosis; D061085:Agenesis of Corpus Callosum; D001139:Arnold-Chiari Malformation / Q000175:diagnosis; D001284:Atrophy; D001369:Axons / Q000473:pathology; D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology; D003616:Dandy-Walker Syndrome / Q000175:diagnosis; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging