Immunity to polioviruses and tetanus after bone marrow transplantation in children.
Immunity to tetanus toxoid and polioviruses was studied in 34 (27 allografted, 7 autografted) children who underwent bone marrow transplantation (BMT). At a median time of 3 years after BMT, only one recipient was seronegative for tetanus toxoid. On the contrary 73% of children were seronegative for at least one of the three poliovirus types and 30% for all virus types. Undetectable antibody titers were more frequently found against type 3 than the other two types. We recommend that reimmunizations of children after BMT be based on serologic tests for antibody titers.
Pezzini
C
C
Clinica Pediatrica dell'Università de Milano, Ospedale San Gerardo, Monza, Italy.
Limonta
M
M
Rovelli
A
A
Uderzo
C
C
Locasciulli
A
A
Maglia
O
O
Masera
G
G
Barbi
M
M
Pozzi
A
A
Luraschi
C
C
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007109:Immunity; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D017955:Poliovirus / Q000276:immunology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D013745:Tetanus Toxoid