Expression of a paternal history of premature myocardial infarction on fibrinogen, factor VIIC and PAI-1 in European offspring--the EARS study. European Atherosclerosis Research Study Group.
To assess the role of genetic and environmental factors in the predisposition to atherosclerosis, 682 students whose father had suffered a myocardial infarction before the age of 55 ("cases") and 1312 controls matched for age and sex, were recruited from 14 Universities in Europe. Fibrinogen, factor VIIc and PAI-1 were compared between cases and controls across European regions. Fibrinogen and factor VIIc were positively correlated with BMI, smoking and contraception. PAI-1 was positively and independently correlated with BMI and waist-to-hip ratio, and negatively with contraception. Factor VIIc and PAI-1 were correlated with cholesterol and triglycerides, and fibrinogen was weakly correlated with LDL-cholesterol. After adjustment for covariates and lipids, fibrinogen level was significantly higher in male cases than in controls (2.38 vs 2.29, p < 0.01). No such difference was found in females (2.59 vs 2.57 - NS). There was no significant case/control difference for factor VIIc and PAI-1. These results support the hypothesis that fibrinogen is a transmissible risk factor of coronary artery disease in males. No such evidence was provided for factor VIIc and PAI-1.
Bara
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L
Laboratoire de Thrombose Expérimentale, Paris VI University, France.
Nicaud
V
V
Tiret
L
L
Cambien
F
F
Samama
M M
MM
D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D000941:Antigens / Q000032:analysis; D001824:Body Constitution; D015992:Body Mass Index; D016022:Case-Control Studies; D003267:Contraception; D004198:Disease Susceptibility; D005060:Europe / Q000453:epidemiology; D005167:Factor VII / Q000032:analysis; D005220:Fathers; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D012307:Risk Factors; D012907:Smoking
D000941:Antigens; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; C042580:factor VII clotting antigen; D005167:Factor VII; D005340:Fibrinogen