Antimicrobial and genotoxic properties of quinoline derivatives.
We continued our research into the biological properties of quinoline derivatives. Newly synthesized 8-sulfonylquinolines, tested against some representative microbial strains and practically inactive, were also studied for the genotoxic properties. The genotoxicity tests were extended to previously synthesized compounds (some 6-substituted 8-quinolinecarboxylic acids, the amide and some esters of 8-quinolinecarboxylic acid and finally the 8-quinolinecarboxaldehyde and two of its derivatives). Rec-assay and Salmonella-microsome tests showed several compounds to be genotoxic; the mutagenic activity seems to be modulated by the nature of the substituents. The results obtained are discussed with the aim of explaining possible structure-activity relationships.
Zani
F
F
Dipartimento Farmaceutico, Università di Parma, Italy.
Carmellino
M L
ML
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011804:Quinolines / Q000494:pharmacology* / Q000633:toxicity*; D051381:Rats; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009153:Mutagens; D011804:Quinolines