Biochemical evaluation of the antiulcerogenic effect of Cauvery-100 (an ayurvedic formulation) in rats.
Due to the varied pathogenesis of ulcers, a number of pharmacologically different antiulcer drugs are now used in the treatment of the condition. The suitability of certain of these drugs is still to be established. Cauvery-100 is an ayurvedic formulation consisting of plant ingredients, and has been suggested to be useful in the treatment of gastrointestinal disorders. In the present study this drug was tested for its antiulcerogenic effect. The number of lesions on gastric mucosa decreased markedly after 15 days oral treatment with Cauvery-100 in rats with indomethacin-induced ulcers. The volume and total acidity of the gastric juice also decreased in the treated rats. The hexose, hexosamine and sialic acid levels of gastric contents, which were increased in untreated rats returned to near normal levels after 15 days of treatment. Protein in the gastric juice was elevated in untreated rats but returned to near normal levels after 15 days of treatment. Cauvery-100 acts both to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent.
Manonmani
S
S
Department of Biochemistry, University of Madras, India.
William
S
S
Subramanian
S
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Govindasamy
S
S
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000930:Antidiarrheals / Q000627:therapeutic use*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism; D007213:Indomethacin; D008297:Male; D008515:Medicine, Ayurvedic; D019158:N-Acetylneuraminic Acid; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000378:metabolism; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D000930:Antidiarrheals; C073389:Cauvery-100; D006595:Hexosamines; D006601:Hexoses; D010936:Plant Extracts; D011506:Proteins; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid; D007213:Indomethacin