title: Effect of aging on urinary excretion of 18-hydroxycortisol.
abstract: The secretion of aldosterone declines with age. We reported that sodium depletion increased urinary excretion of 18-hydroxycortisol (18-OH-F). To elucidate the effect of aging on urinary excretion of 18-OH-F, we measured urinary 18-OH-F in 30 normotensive subjects aged 20-70 yr. There were significant negative correlations between age and urinary excretion of 18-OH-F or of aldosterone (r = -0.49, r = -0.58, P < 0.05, respectively) but not of urinary free cortisol. These results suggest that angiotensin may contribute to chronic regulation of 18-OH-F.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: I
authors.initials: I
authors.lastname: Miyamori
authors.forename: T
authors.initials: T
authors.lastname: Yoneda
authors.forename: K
authors.initials: K
authors.lastname: Iki
authors.forename: H
authors.initials: H
authors.lastname: Hatakeyama
authors.forename: R
authors.initials: R
authors.lastname: Takeda
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000450:Aldosterone / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D000450:Aldosterone; C033689:18-hydroxycortisol; D006854:Hydrocortisone