title: [Assessment of myocardial metabolic reserve with positron emission tomography and C-11 acetate].
abstract: Positron emission tomography (PET) with C-11 acetate allows noninvasive quantification of myocardial oxidative metabolism. To assess the myocardial metabolic reserve, clearance of C-11 acetate from the myocardium was measured with PET in 8 normal subjects at rest and during the infusion of dobutamine (inotropic agent) or dipyridamole (vasodilator). During dobutamine infusion, the clearance rate constant of C-11 acetate increased significantly (0.063 +/- 0.014 vs 0.109 +/- 0.016, p < 0.002) in good correlation with the rate-pressure product (r = 0.83). During dipyridamole infusion, myocardial acetate clearance also significantly increased (0.088 +/- 0.024, p < 0.05) in correlation with the rate-pressure product (r = 0.54). In normal myocardium, myocardial oxidative metabolism increased in response to increased work load with pharmacological stress. These findings suggest that PET with C-11 acetate and pharmacological stress may be a promising approach for the evaluation of metabolic reserve in patients with ischemic heart disease.
authors.affiliation: Department of Internal Medicine, Kyoto University Faculty of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Ono
authors.forename: R
authors.initials: R
authors.lastname: Nohara
authors.forename: H
authors.initials: H
authors.lastname: Kambara
authors.forename: K
authors.initials: K
authors.lastname: Okuda
authors.forename: I H
authors.initials: IH
authors.lastname: Mohiuddin
authors.forename: N
authors.initials: N
authors.lastname: Tamaki
authors.forename: J
authors.initials: J
authors.lastname: Konishi
mesh_terms: D000085:Acetates; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002250:Carbon Radioisotopes; D004176:Dipyridamole; D004280:Dobutamine; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D004280:Dobutamine; D004176:Dipyridamole