[An animal experiment on transplacental transport of ceftazidime at various terms of pregnancy].
The experiments on rats revealed good transplacental transfer of ceftazidime to the fetus. The level of the transfer increased with increasing of the pregnancy term. The antibiotic concentration in the fetal tissues exceeded the MIC for opportunistic organisms. The ceftazidime concentrations in the amniotic fluid were equal to the therapeutic ones at the early and late terms of the pregnancy. At the early terms of the pregnancy the antibiotic transferred to the amniotic fluid transplacentally. The data are in favour of recommending ceftazidime for prophylaxis and treatment of fetal intrauterine infections.
Kasabulatov
K K
KK
Manuĭlov
K K
KK
Voropaeva
S D
SD
D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002442:Ceftazidime / Q000493:pharmacokinetics*; D005260:Female; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D002442:Ceftazidime
Transplatsentarnyĭ perekhod tseftazidima v éksperimente u zhivotnykh v raznye sroki beremennosti.