title: [Effects of N-acetylasparaginic acid during frontal lobectomy in the rat: antiamnestic action and effect on monoamine level].
abstract: Effects of N-acetyl-aspartic acid (NAA) on the behaviour models "open field", passive avoidance test and content of monoamines and their metabolites in the brain areas on the 9-th day after frontal decortication were studied. NAA (50 mg/kg), i.p., daily, 9 days) exerted antiamnestic effect in decorticated rats, evaluated in passive avoidance test. Corresponding changes in concentration of serotonin and 5-hydroxyindolacetic acid in the brain of decorticated rats were also seen.
authors.forename: T V
authors.initials: TV
authors.lastname: Grekhova
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: R R
authors.initials: RR
authors.lastname: Gaĭnetdinov
authors.forename: V S
authors.initials: VS
authors.lastname: Kudrin
authors.forename: K S
authors.initials: KS
authors.lastname: Raevskiĭ
mesh_terms: D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D005625:Frontal Lobe / Q000601:surgery*; D008297:Male; D051381:Rats
chemical_list: D015306:Biogenic Monoamines; D001224:Aspartic Acid; C000179:N-acetylaspartate
vernacular_title: Effekty N-atsetilasparaginovoĭ kisloty pri frontal'noĭ lobéktomii mozga krys: antiamnesticheskoe deĭstvie i vliianie na soderzhanie monoaminov.