Five year survival rate in endometrial carcinoma stages I--II: influence of degree of tumour differentiation, age, myometrial invasion and DNA content.
OBJECTIVE
To compare the prognostic capability of clinical stage, tumour differentiation, myometrial invasion, age and DNA content in endometrial carcinoma. Then to use the results to identify a small, high risk group suitable for more intensive adjuvant therapy.


METHODS
A prospective five year follow up between June 1980 and June 1987.


METHODS
Department of Oncology, gynaecological section, University Hospital, Lund, Sweden. Endometrial tissue was obtained immediately prior to treatment for flow cytometric DNA analysis.


METHODS
Two hundred and fifty-one patients referred for treatment.


METHODS
None.


RESULTS
Age, myometrial invasion of greater than 50%, and number of DNA populations (ploidy) were the only significant parameters related to survival. By combining myometrial invasion and number of DNA populations, we divided the patients into four groups. A very small high risk group was identified (7%) with a low survival rate (61%). Two intermediate groups with either myometrial invasion exceeding 50% or with more than one DNA population present constituted 34% of the patients and these had an overall survival rate of 75% and a relatively large low risk group of 59% of the patients (with a survival rate of 95%) was constructed out of those without deep myometrial invasion and demonstrating only one DNA population.


CONCLUSIONS
These data suggest that number of DNA populations and depth of myometrial invasion could be combined to identify a small high risk group (7%) with a low survival rate (61%) suitable for adjuvant therapy.
Lindahl
B
B
Department of Obstetrics and Gynaecology, University Hospital, Lund, Sweden.
Ranstam
J
J
Willén
R
R
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D016889:Endometrial Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D004739:England / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D011446:Prospective Studies; D016196:S Phase; D015996:Survival Rate; D013997:Time Factors