[Changes in the cellular proliferation of the healthy mucosa in patients with colorectal cancer].
OBJECTIVE
To analyze differences in the proliferative pattern of normal mucosa between patients with colorectal cancer and healthy subjects.


METHODS
By using flow cytometry we examined the proliferative pattern (Proliferative Index and S-Phase) in samples of normal mucosa from 34 patients operated on for colorectal cancer at our hospital and from 14 healthy subjects as a control group.


RESULTS
All examined samples were diploid. The Proliferative Index and S-Phase in the Cancer Group were significantly higher than in the Control Group (16.7 +/- 5.9 vs 11.4 +/- 4, p < 0.003, and 11.9 +/- 3.9 us 6.6 +/- 3 p < 0.0004).


CONCLUSIONS
These findings provide evidence for an altered proliferative pattern in the healthy colonic mucosa of patients with colorectal cancer.
Bianchi
A
A
Servicio de Cirugía General, Consorci Sanitari de Mataró.
Mallofre
C
C
Soler
T
T
Diloy
R
R
García
A
A
Suñol
J
J
Barja
J
J
Hidalgo
L
L
Ubach
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
Alteraciones de la proliferación celular de la mucosa sana en pacientes con cáncer colorrectal.