Rifampin for therapy of experimental pneumococcal meningitis in rabbits.
Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.
Nau
R
R
Infectious Diseases Laboratory, San Francisco General Hospital, California 94110.
Kaye
K
K
Sachdeva
M
M
Sande
E R
ER
Täuber
M G
MG
D000818:Animals; D002443:Ceftriaxone / Q000627:therapeutic use; D004357:Drug Synergism; D008586:Meningitis, Pneumococcal / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D012293:Rifampin / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D015610:Serum Bactericidal Test; D013296:Streptococcus pneumoniae / Q000187:drug effects
D002443:Ceftriaxone; D012293:Rifampin