[Electric activity in the dorsal horns of the spinal cord and somatosensory cortex in rats with and without development of pain syndrome after sciatic nerve transection].
Bioelectric activity in dorsal horn of spinal cord and somatosensory cortex have been studied in rats with and without pain syndrome after sciatic nerve section. The results show that in rats with pain syndrome (the development of pain syndrome determined in appearance of autotomies on the limb with cutting nerve and decrease of pain threshold) simultaneous increase of amplitude of evoked potentials (EPs) in contralateral somatosensory cortex and ipsilateral dorsal horn of lumbal segments by electrical stimulation of the injured limb are to be observed. In rats without pain syndrome (rats without autotomies and hyperalgesia) the EPs increase have been registered only in dorsal horn of spinal cord. The results are discussed on the basis of the theory of generator and systemic mechanisms of formation of neurogenic pain syndrome: the pain syndrome is clinical manifestation of the pathologic algic system (PAS) which includes the neurons of the dorsal horn and of the somatosensory cortex.
Kryzhanovskiĭ
G N
GN
Reshetniak
V K
VK
Kukushkin
M L
ML
Smirnova
V S
VS
Zinkevich
V A
VA
D000818:Animals; D005071:Evoked Potentials / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012584:Sciatic Nerve / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000503:physiopathology*; D013116:Spinal Cord / Q000503:physiopathology*; D013577:Syndrome
Elektricheskaia aktivnost' v dorsal'nykh rogakh spinnogo mozga i somatosensornoĭ kore u krys s razvivshimsia i nerazvivshimsia bolevym sindromom posle pererezki sedalishchnogo nerva.