Ligand-receptor interactions. Multidimensional mathematical method of analysis.
The paper embraces information about the character of interaction between pharmacologically active ligands and 11 G-protein-dependent receptors of neurotransmitters. The data are analyzed by the methods of correlation and cluster analyses and of main components. An essential pharmacological affinity is revealed to exist between the receptors which regulate an inhibitory link of the adenylate cyclase system and receptors which activate Ca(2+)-mobilizing polyphosphoinositide system of secondary transmitters. Receptors which activate adenylate cyclase are rather different pharmacologically from two previous groups. Interrelation between the structure and physico-chemical properties of binding sites on receptors and efficiency of their interaction with ligand is discussed.
Radchenko
I V
IV
Institute of Bioorganic and Petrolemum Chemistry, Kyiv, Ukraine.
Dityatev
A E
AE
Batrak
G N
GN
Luik
A I
AI
D000262:Adenylyl Cyclases / Q000378:metabolism; D003627:Data Interpretation, Statistical; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000502:physiology; D008024:Ligands; D008433:Mathematics; D017982:Receptors, Biogenic Amine / Q000187:drug effects / Q000378:metabolism*
D008024:Ligands; D017982:Receptors, Biogenic Amine; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases