title: Xenotransplantation rejection is antibody-mediated in both sensitized and nonsensitized recipients.
abstract: This study analyzes the mechanisms involved in xenotransplantation rejection between closely related species. Hamster hearts were transplanted heterotopically into both normal rats and rats previously sensitized by the transfusion of donor blood. Sequential ultrastructural and immunohistochemical analyses were performed on the grafts, spleens, and sera. The data obtained support the view that induced antibodies directed against the xenograft endothelium play a very important role in producing graft damage. Moreover, the demonstration of antibodies against myocyte determinants suggests that it is possible, in this particular model, that the antiendothelial antibodies are not the only ones involved in the injury process.
authors.affiliation: Pittsburgh Transplantation Institute, University of Pittsburgh, Pennsylvania.
authors.forename: I R
authors.initials: IR
authors.lastname: Marino
authors.forename: S
authors.initials: S
authors.lastname: Celli
authors.forename: M
authors.initials: M
authors.lastname: Catena
authors.forename: S
authors.initials: S
authors.lastname: Gatti
authors.forename: G
authors.initials: G
authors.lastname: Zetti
authors.forename: G
authors.initials: G
authors.lastname: Ferla
authors.forename: H R
authors.initials: HR
authors.lastname: Doyle
authors.forename: N
authors.initials: N
authors.lastname: Maggiano
authors.forename: P
authors.initials: P
authors.lastname: Musiani
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood*; D006224:Cricetinae; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D007114:Immunization; D007150:Immunohistochemistry; D008647:Mesocricetus; D051381:Rats; D011917:Rats, Inbred Lew; D012016:Reference Values; D014183:Transplantation, Heterologous
chemical_list: D000906:Antibodies