[Active factors released by endothelial cells in acute leukemia].
In recent years, it is known that endothelial cells play an important role in the genesis of some diseases, but there are only few papers dealing with the role of endothelial cells in leukemia. In this study some of the active factors released by the endothelial cells in patients with acute leukemia such as von Willebrand factor, prostaglandin, fibronectin, tissue-type plasminogen activator and its inhibitor were determined. It was found that the levels of these factors changed significantly in patients with acute leukemia, as compared with those in normal controls, especially in cases with bleeding tendency and infection. The possible mechanism and the clinical significance were discussed.
Shen
J Z
JZ
Fujan Institute of Hematology, Fujan Medical College, Fuzhou.
Lü
L H
LH
Wang
C Q
CQ
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism*
D000941:Antigens; D005353:Fibronectins; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D015121:6-Ketoprostaglandin F1 alpha