Risk factors for chronic rejection in heart and lungs--why do hearts and lungs rot?
The major cause of graft loss and patient death during the 1st yr after heart transplantation is progressive coronary occlusive disease. All survival curves show progressive and persistent graft loss over time. To improve the overall results of heart transplantation, attention must be directed to the etiology, prevention, and treatment of coronary occlusive disease. This condition affects both small and large vessels, and most probably results from a continuous immune insult that generates smooth muscle proliferation and subsequent development of atheromatous plaque. Multivariate analysis suggests that highly significant risk factors for the development of coronary occlusive disease include preoperative diagnosis of ischemic heart disease, age of recipient, and age of donor. Other risk factors, notably cytomegalovirus (CMV) infection, have not proved to be independent causes of coronary occlusive disease in our series. Diagnosis before the occlusive disease sets in, as well as the development of new therapeutic strategies, may prevent or delay the onset of coronary artery disease, thereby improving overall results of heart transplantation. Graft loss from lung transplantation after the 1st yr is associated with obliterative bronchiolitis. This final end-stage progressive loss of small airways can be seen not only in transplanted lungs but in lungs with chronic infection. It appears to be a final common pathway for lung injury, but following transplantation it is most likely to be mediated by rejection. Risk factor analysis in our series indicates that severe or persistent rejection in the first few months is associated with the subsequent development of obliterative bronchiolitis.(ABSTRACT TRUNCATED AT 250 WORDS)
Wallwork
J
J
Papworth Hospital, Cambridge, England.
D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000503:physiopathology; D002423:Cause of Death; D002908:Chronic Disease; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology; D005541:Forced Expiratory Volume / Q000502:physiology; D006084:Graft Rejection / Q000209:etiology* / Q000503:physiopathology; D016027:Heart Transplantation / Q000009:adverse effects / Q000502:physiology; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects / Q000502:physiology; D009203:Myocardial Infarction / Q000209:etiology; D017202:Myocardial Ischemia / Q000150:complications; D011658:Pulmonary Fibrosis / Q000209:etiology; D012307:Risk Factors; D015996:Survival Rate