Inhibitory effect of spironolactone on the contractions of the rabbit uterine horn and the human myometrial strip.
The spontaneous contractions of the rabbit uterine horns and the human myometrial strips were stimulated by oxytocin and buserelin acetate in isolated preparations. Spironolactone application to these models produced inhibitory effects on the contractions. It is concluded that spironolactone has inhibitory effect on the rabbit uterine horn and the human myometrial strip contractions.
Coksevim
B
B
Department of Physiology, University of Erciyes, Faculty of Medicine, Kayseri, Turkey.
Tayyar
M
M
D000818:Animals; D002064:Buserelin / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009215:Myometrium / Q000187:drug effects* / Q000502:physiology; D010121:Oxytocin / Q000494:pharmacology; D011817:Rabbits; D013148:Spironolactone / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D013148:Spironolactone; D010121:Oxytocin; D002064:Buserelin