Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120.
Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.
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National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894.
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008780:Methyltransferases / Q000737:chemistry*; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry*; D011496:Protein Methyltransferases; D017386:Sequence Homology, Amino Acid; D012359:tRNA Methyltransferases
D009687:Nuclear Proteins; D008780:Methyltransferases; C065028:NOP2 protein, human; C512901:Nop2 protein, mouse; D011496:Protein Methyltransferases; D012359:tRNA Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase