Blue gods, blue oil, and blue people.
Studies of the composition of coal tar, which began in Prussia in 1834, profoundly affected the economies of Germany, Great Britain, India, and the rest of the world, as well as medicine and surgery. Such effects include the collapse of the profits of the British indigo monopoly, the growth in economic power of Germany based on coal tar chemistry, and an economic crisis in India that led to more humane tax laws and, ultimately, the independence of India and the end of the British Empire. Additional consequences were the development of antiseptic surgery and the synthesis of a wide variety of useful drugs that have eradicated infections and alleviated pain. Many of these drugs, particularly the commonly used analgesics, sulfonamides, sulfones, and local anesthetics, are derivatives of aniline, originally called "blue oil" or "kyanol." Some of these aniline derivatives, however, have also caused aplastic anemia, agranulocytosis, and methemoglobinemia (that is, "blue people"). Exposure to aniline drugs, particularly when two or three aniline drugs are taken concurrently, seems to be the commonest cause of methemoglobinemia today.
Fairbanks
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Division of Hematology and Internal Medicine, Mayo Clinic Rochester, Minnesota 55905.
D000814:Aniline Compounds / Q000009:adverse effects / Q000266:history*; D002273:Carcinogens / Q000266:history*; D003033:Coal Tar / Q000266:history*; D004396:Coloring Agents / Q000266:history*; D005858:Germany; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D007194:India; D007203:Indigo Carmine; D007211:Indoles / Q000266:history*; D008708:Methemoglobinemia / Q000139:chemically induced / Q000266:history*
D000814:Aniline Compounds; D002273:Carcinogens; D004396:Coloring Agents; D007211:Indoles; D003033:Coal Tar; D007203:Indigo Carmine; C023650:aniline