title: [Preliminary trials of oral immunization of wild animals against anthrax].
abstract: As a pilot trial for the vaccination of game in African game parks against anthrax, trials with guinea-pigs were undertaken to vaccinate the animals orally against anthrax. The vaccine has been prepared with the Göettingen Bioreactor Technology obtaining sporulation in suspension. Guinea-pigs vaccinated orally and subcutaneously with the vaccine resisted a challenge of 1000 spores with a pathogen field strain isolated from elephants in Zambia. With a challenge dosis of 2500 spores orally and subcutaneously immunized animals died. A technique has been developed to identify anthrax organisms excreted with the faeces by means of gas chromatography.
authors.affiliation: Institut für Pfanzenbau und Tierhygiene in den Tropen und Subtropen, Georg-August-Universität Göttingen.
authors.forename: J
authors.initials: J
authors.lastname: Rengel
authors.forename: H
authors.initials: H
authors.lastname: Böhnel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000835:Animals, Wild; D000881:Anthrax / Q000517:prevention & control / Q000662:veterinary*; D001408:Bacillus anthracis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage; D006168:Guinea Pigs; D007279:Injections, Subcutaneous / Q000662:veterinary; D010865:Pilot Projects; D014611:Vaccination / Q000662:veterinary*
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Vorversuche zur oralen Immunoisierung von Wildtieren gegen Milzbrand.