Healing of chronic gastric ulcer depends on gastric mucosal prostaglandin synthesis.
In the present study, the role of endogenous prostanoid synthesis in gastric mucosa in the healing of chronic gastric ulcers was investigated. Nineteen patients were divided into two groups in accordance with healing state after one month of treatment with cimetidine only: "healed group" and "unhealed group". Biopsy specimens taken from the mucosa around the ulceration (damaged gastric mucosa) and at a distance from the ulceration (normal gastric mucosa) at endoscopy prior to treatment were homogenized, and the mucosal prostanoid synthesis was determined using [14C]arachidonic acid. The mean value of prostaglandin E2 synthesis in the normal gastric mucosa of the healed group was 60% higher than in that of the unhealed group, but the difference was not significant. However, prostaglandin E2 synthesis in the damaged gastric mucosa of the healed group was 117% higher than in that of the unhealed group. The same tendency was observed for prostaglandin D2 and 6-keto prostaglandin F1 alpha synthesis as for prostaglandin E2. In our study it was demonstrated that there is a good correlation of prostaglandin synthesis in the damaged mucosa with healing of chronic gastric ulceration. Furthermore, our study indicated that prostaglandin synthesis, especially in damaged mucosa, might be important in the healing of gastric ulceration.
Mine
T
T
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
Kataoka
A
A
Fujisaki
J
J
Sato
E
E
Yasuda
H
H
Inaba
Y
Y
Akimoto
K
K
Mashima
H
H
Ogata
E
E
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000328:Adult; D000368:Aged; D001345:Autoradiography; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015230:Prostaglandin D2 / Q000096:biosynthesis; D011453:Prostaglandins / Q000096:biosynthesis*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; D002927:Cimetidine; D015232:Dinoprostone; D015230:Prostaglandin D2