title: Comparative QSAR studies of two series of 1,4-dihydropyridines as slow calcium channel blockers.
abstract: Quantitative structure activity analysis was applied to two series of dihydropyridine (DHP) calcium channel blocking agents. One series of compounds was composed of DHPs substituted in the 4-position with an ortho or meta nitro substituted phenyl ring. The second group consisted of DHPs substituted at the 4-position with a novel thieno [3,2-c] pyridine ring. Both series consisted of compounds with unsymmetrical ester substitutions on the dihydropyridine ring. The antihypertensive activity of the compounds were determined in a spontaneously hypertensive rat model. Regression analysis indicated the antihypertensive activity of an i.v. dose correlated with the calculated octanol/water coefficent (clogP). Regression analysis did not find correlation with the in vitro potency and the clogP values.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
authors.forename: J H
authors.initials: JH
authors.lastname: Wikel
authors.forename: K G
authors.initials: KG
authors.lastname: Bemis
authors.forename: K
authors.initials: K
authors.lastname: Kurz
authors.forename: M L
authors.initials: ML
authors.lastname: Denney
authors.forename: B W
authors.initials: BW
authors.lastname: Main
authors.forename: R A
authors.initials: RA
authors.lastname: Moore
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Shingleton
authors.forename: D R
authors.initials: DR
authors.lastname: Holland
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D012044:Regression Analysis; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines