title: [Results of a case-control study of the current effect of various factors on risk of cervix cancer. 1. Factors in reproduction, sex behavior and infectious genital diseases].
abstract: We performed a case control study to determine factors which influence the development of cervical carcinoma. Factors like reproduction, sexual behaviour and genital infections were considered. 309 patients with cervical intraepithelial neoplasia (CIN) or invasive cervical carcinoma were interviewed as a study group. 490 patients with no cervical changes served as control group. The two groups of patients had a different age distribution with an early age summit in the study group. No differences were observed in relation to residence areas and attendance of screening for cervical carcinoma. 83.5% of the women in the study group (n = 258) and 81.0% (n = 397) of the control group attended the screening for cervical carcinoma. According to our observation, the following factors increased the risk of CIN or invasive cervical carcinoma: early menarche (< 14 years vs > 14 years), multiparity (0 vs 1-3 vs > 4), first pregnancy before the age of 20, divorced women, early sexual contact (< 14-17 years vs 18-21 years vs > 21 years), multiple sexual partners, vaginal discharge and venereal diseases (gonorrhea, syphilis). Factors like reproductive characteristics and genital infections can be interpreted as expressions of sexual behaviour. Despite the improving social status, increasing health consciousness and extensive mass-screening for cervical cancer, the above mentioned risk factors still play an important role. Risk group should be followed and examined strictly so as to reduce the rate of invasive cervical carcinoma in screened patients.
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe, Universität Leipzig.
authors.forename: U
authors.initials: U
authors.lastname: Köhler
authors.forename: P
authors.initials: P
authors.lastname: Wuttke
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006069:Gonorrhea / Q000150:complications; D006801:Humans; D008572:Menarche; D008875:Middle Aged; D010298:Parity; D012307:Risk Factors; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000150:complications*; D013587:Syphilis / Q000150:complications; D002583:Uterine Cervical Neoplasms / Q000209:etiology*; D002578:Uterine Cervical Dysplasia / Q000209:etiology*
vernacular_title: Ergebnisse einer Fall-Kontroll-Studie zum aktuellen Einfluss verschiedener Faktoren auf das Zervixkarzinomrisiko. 1. Mitteilung: Faktoren der Reproduktion, des Sexualverhaltens und infektiöse Genitalerkrankungen.