title: In vivo detection of myelin phospholipids in multiple sclerosis with phosphorus magnetic resonance spectroscopic imaging.
abstract: The goal of this study was to investigate myelin phospholipids in vivo in multiple sclerosis lesions and normal-appearing white matter by evaluating the spectral broad component from phosphorus 31 magnetic resonance spectroscopic imaging data. The phospholipid broad component was reduced nearly 35% (p < 0.001) in both lesions and in normal-appearing white matter in multiple sclerosis subjects compared to control subjects, suggesting reduced myelin phospholipid concentration or altered relaxation times.
authors.affiliation: Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121.
authors.forename: C A
authors.initials: CA
authors.lastname: Husted
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: D A
authors.initials: DA
authors.lastname: Adams
authors.forename: D S
authors.initials: DS
authors.lastname: Goodin
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D010758:Phosphorus
chemical_list: D010743:Phospholipids; D010758:Phosphorus