New heterocyclic derivatives of benzimidazole with germicidal activity. X-In vivo toxicity of 5-fluoro-2-(5'-nitro-2'-furyl)-benzimidazole (F-O-NO2); preliminary observations.
The in vivo toxicity of 5-fluoro-2-(5'-nitro-2'-furyl) benzimidazole vehiculated in liposomes (L-FONO2), induced in mice by intraperitoneal injection, was evaluated. Toxicity was tested looking at the liver and kidney damage by determining some specific functional parameters (seric urea, seric GPT and urinary beta-NAG): no modifications were observed after administration of L-FONO2 for seven days.
Pedini
M
M
Istituto di Biochimica e Chimica Medica, Università degli Studi di Perugia, Italia.
De Meo
G
G
Ricci
A
A
Tassi
C
C
Bastianini
L
L
D000118:Acetylglucosaminidase / Q000652:urine; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000652:urine; D004202:Disinfectants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000201:enzymology; D008081:Liposomes; D051379:Mice; D008815:Mice, Inbred Strains
D001562:Benzimidazoles; D004202:Disinfectants; D008081:Liposomes; C042757:5-fluoro-(2'-nitrofuryl)-2-benzimidazole; D003404:Creatinine; D000410:Alanine Transaminase; D000118:Acetylglucosaminidase