Ephedrine enhances analgesic effect of morphine.
Morphine-ephedrine interaction on analgesia was studied in mice (n = 240) and in post-operative patients (n = 32). It was found that combining morphine and ephedrine enhances analgesia which is not significantly different from the effect of morphine given alone at double dose.
Tekol
Y
Y
Department of Pharmacology, Erciyes University, Medical Faculty, Kayseri, Turkey.
Tercan
E
E
Esmaoğlu
A
A
D000328:Adult; D000698:Analgesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001842:Bone and Bones / Q000601:surgery; D004311:Double-Blind Method; D004357:Drug Synergism; D004809:Ephedrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects; D010149:Postoperative Pain / Q000517:prevention & control; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D010919:Placebos; D009020:Morphine; D004809:Ephedrine