Evidence that neuropeptide Y is a physiological signal for normal food intake.
Neuropeptide Y is the most potent orexigenic signal known. To test the hypothesis that NPY is a physiological messenger molecule for normal food intake in rats, we studied the effects of passive immunization against endogenous NPY on cumulative daily food intake in non-fasted spontaneously feeding rats. The results show that continuous central infusion of NPY antibodies markedly suppressed the nighttime and the cumulative 24 h food intake in a dose-dependent fashion. These results support the hypothesis that NPY may be a physiological signal involved in the stimulation of ingestive behavior in rats.
Dube
M G
MG
Department of Physiology, University of Florida College of Medicine, Gainesville 32610-0244.
Xu
B
B
Crowley
W R
WR
Kalra
P S
PS
Kalra
S P
SP
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D002552:Cerebral Ventricles / Q000502:physiology*; D002940:Circadian Rhythm; D005247:Feeding Behavior / Q000502:physiology*; D007116:Immunization, Passive; D007263:Infusions, Parenteral; D008297:Male; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000906:Antibodies; D009478:Neuropeptide Y