Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.
The nucleotide sequence of the ileS gene conferring high-level resistance to mupirocin in Staphylococcus aureus J2870 has been determined. The gene sequence is substantially different from that of the native ileS gene of S. aureus, indicating that high-level resistance to mupirocin results from the acquisition of a novel ileS gene.
Hodgson
J E
JE
Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth Surrey, United Kingdom.
Curnock
S P
SP
Dyke
K G
KG
Morris
R
R
Sylvester
D R
DR
Gross
M S
MS
D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D008969:Molecular Sequence Data; D016712:Mupirocin / Q000494:pharmacology*; D016366:Open Reading Frames; D012355:RNA, Transfer, Ile / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
D003062:Codon; D004269:DNA, Bacterial; D012355:RNA, Transfer, Ile; D016712:Mupirocin