title: Injection of multiple sperm into the perivitelline space as a treatment of male infertility.
abstract: This paper reports the outcome of 274 treatment cycles using multiple injection of sperm into the perivitelline space as a treatment of male factor infertility. A total of 170 couples underwent this form of treatment; 59.1% of cycles had at least one oocyte normally fertilized with an overall normal fertilization rate of 17.2%. The development rate of normally fertilized embryos was high (98.5%) and resulted in a pregnancy rate (positive human chorionic gonadotrophin 18 days after embryo transfer) of 21.4% per embryo transfer procedure (a maximum of 3 embryos were transferred per procedure). The relationship between the number of sperm injected and the fertilization rate and other factors affecting the outcome are discussed.
authors.affiliation: Human Reproduction Unit, Royal North Shore Hospital, St Leonards, NSW, Australia.
authors.forename: C
authors.initials: C
authors.lastname: O'Neill
authors.forename: J P
authors.initials: JP
authors.lastname: Ryan
authors.forename: J W
authors.initials: JW
authors.lastname: Catt
authors.forename: I L
authors.initials: IL
authors.lastname: Pike
authors.forename: U B
authors.initials: UB
authors.lastname: Krzyminska
mesh_terms: D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007248:Infertility, Male; D008297:Male; D008845:Microinjections; D011247:Pregnancy; D013094:Spermatozoa; D014817:Vitelline Membrane