A follow-up study of immunoglobulin levels and autoantibodies in an unselected pregnant population.
OBJECTIVE
To obtain a systematic view of changes in the levels of immunoglobulins (Igs), other serum proteins, and autoantibodies during pregnancy and postpartum.


METHODS
A series of 220 women were followed throughout pregnancy and four to six months postpartum.


RESULTS
Immunoglobulin G (IgG) concentration clearly decreased toward term. The concentrations of IgM and IgA decreased only slightly. In most instances autoantibody levels paralleled changes in the corresponding immunoglobulin class levels. In few cases, however, there were clear deviations from this. With respect to IgG class autoantibodies, the highest autoantibody levels were found in the postpartum specimen. IgM class autoantibody levels remained almost constant throughout the follow-up period.


CONCLUSIONS
The intrapregnancy decrease of IgG is mainly due to hemodilution, but when the effect of hemodilution is taken into account, total amounts of IgM and IgA are increased. The results suggests that compared to IgG the regulatory mechanisms of IgM and IgA are altered during pregnancy.
Ailus
K T
KT
Department of Immunobiology, National Public Health Institute, Helsinki, Finland.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D008875:Middle Aged; D010298:Parity / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D011261:Pregnancy Trimester, First / Q000276:immunology; D011263:Pregnancy Trimester, Third / Q000276:immunology
D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins