Isradipine decreases arterial thrombogenicity in rabbits. A morphometric and radioisotopic study.
The effect of isradipine, a calcium antagonist, on aortic and iliac wall thrombogenicity was examined in rabbits. After one week of dosing, the abdominal aortic and iliac artery endothelium was abraded using a Fogarthy catheter. One group of animals (n = 8) was dosed for one week with isradipine 0.3 mg/kg. A second group of animals received 10 mg acetylsalicylic acid (ASA)/kg daily in addition, while a third group received the vehicle only. Finally, a fourth group of animals (n = 8) was treated with ASA only. The percentage denuded surface covered with contact (unspread) platelets decreased significantly (p < 0.01) from 14.7 +/- 2.0 to 9.3 +/- 2.1 (6.2 +/- 0.8 to 3.7 +/- 0.4). The amount of contact and spread platelets was diminished from 84.9 +/- 5.6 to 71.4 +/- 4.4 (91.8 +/- 5.3 to 75.2 +/- 4.6). Platelet thrombi decreased from 7.4 +/- 0.9 to 4.6 +/- 1.4 (9.4 +/- 1.9 to 5.2 +/- 0.7) in the aortic and the iliac artery, respectively. In-platelet deposition decreased by 39.9 and 41.9%. Concomitant ASA therapy not only abolished the effect of isradipine but enhanced thrombogenicity, probably as a result of almost complete blockade of vascular PGI2-production.
Fitscha
P
P
2nd Department of Internal Medicine, Policlinic, Vienna, Austria.
Keiler
A
A
O'Grady
J
J
Peskar
B A
BA
Sinzinger
H
H
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D011464:Epoprostenol / Q000096:biosynthesis; D007083:Iliac Artery / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007205:Indium Radioisotopes; D017275:Isradipine / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D013927:Thrombosis / Q000473:pathology / Q000517:prevention & control*
D007205:Indium Radioisotopes; D011464:Epoprostenol; D017275:Isradipine