title: [Role of hereditary factors in the formation of secondary insulin dependence in patients with type II diabetes mellitus].
abstract: A total of 389 patients with diabetes mellitus were examined. A genetic analysis has shown a most high possibility of diabetes in the sibs of patients with type II diabetes and secondary insulin dependence. The authors put forward a hypothesis that secondary insulin dependence formation in diabetics with type II condition results from interactions of two gene complexes with a recessive effect, responsible for types I and II diabetes mellitus development. They suggest a model of age-dependent epistasis with an 'insulin-dependence' gene quantitative effect.
authors.forename: S A
authors.initials: SA
authors.lastname: Shtandel'
authors.forename: L A
authors.initials: LA
authors.lastname: Artamentova
authors.forename: E P
authors.initials: EP
authors.lastname: Tikhonova
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D006801:Humans
vernacular_title: Rol' nasledstvennykh faktorov v formirovanii vtorichnoĭ insulinzavisimosti u bol'nykh sakharnym diabetom II tipa.