Modulation by intracellular Ca++ of GABA activated Cl- extrusion from Deiters' neuron.
The increase in 36Cl- in --> out permeation across plasma membranes from the Deiters' neurons by GABA on the cytoplasmic side is modulated by Ca++. The GABA stimulation was maximal with Ca++ on the intracellular side at the physiologically likely concentration of 3 x 10(-8) M. A lower effect was found in the 10(-7) - 10(-5) M [Ca++]i range with a total disappearance of it at [Ca++] of .2 mM. This Cl- extrusion mechanism is likely to be involved in the establishment of a Cl- out --> in electrochemical gradient. Modulation of it by intracellular Ca++ transients may be of physiological importance.
Rapallino
M V
MV
Centro di Neurofisiologia Cerebrale, C. N. R., Genova, Italy.
Cupello
A
A
Hydén
H
H
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D015220:Calcium Channels / Q000097:blood*; D002463:Cell Membrane Permeability / Q000187:drug effects; D008297:Male; D009433:Neural Inhibition; D011817:Rabbits; D018079:Receptors, GABA / Q000187:drug effects; D003689:Vestibular Nucleus, Lateral / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D015220:Calcium Channels; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid; D002118:Calcium