Gadoteridol dose dependence in MR imaging of a liver abscess model.
A necrotic liver abscess model was studied with magnetic resonance (MR) imaging at 1.5 T before and after intravenous administration of gadoteridol at doses of 0.1, 0.25, and 0.5 mmol/kg in 24 rabbits. Enhancement characteristics and lesion delineation were assessed with both breath-hold and non-breath-hold imaging techniques. Lesion delineation, as assessed both by signal intensity measurements and evaluations by two image readers blinded to imaging technique, was greatest on high-dose (0.5 mmol/kg) breath-hold images. Lesion rim enhancement was seen consistently only on postcontrast images obtained at a dose of 0.5 mmol/kg and progressed with time after injection of contrast material.
Runge
V M
VM
Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, St. Lexington 40536-0098.
Kirsch
J E
JE
Woolfolk
C
C
Brack
M A
MA
Garneau
R A
RA
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D005682:Gadolinium / Q000008:administration & dosage; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008100:Liver Abscess / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009336:Necrosis; D009942:Organometallic Compounds / Q000008:administration & dosage; D011817:Rabbits; D013997:Time Factors
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium