title: [Neuro-ophthalmologic complications of disseminated lupus erythematosus].
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) is a multisystemic inflammatory disease of unknown etiology. Physiopathology includes small vessel occlusion and auto-antibody production. Neuro-ophthalmic complications can be detected in 10-30% of SLE cases. Further, some patients can present with neuro-ophthalmic complications prior to diagnosis of SLE.
  
  
  METHODS
  We report seven cases of neuro-ophthalmic complications of SLE demonstrating lesions from the retina to the brain. The other possible manifestations of SLE will be reviewed.
  
  
  RESULTS
  Two cases were not yet diagnosed with SLE when neuro-ophthalmic disease occurred. Anti-double stranded DNA antibodies were detected at a very high titer, suggesting SLE, later confirmed by rheumatologists.
  
  
  CONCLUSIONS
  Ophthalmologists should be aware of the unusual patient presenting with a neuroophthalmic disorder prior to the diagnosis of SLE. In such cases, autoantibodies should be sought. Antinuclear antibodies are very sensitive but non specific for SLE. Anti-double stranded DNA antibodies are specific for SLE and elevated titer should raise the suspicion of undiagnosed SLE.
authors.affiliation: Hôpital Ophtalmique Jules Gonin, Lausanne.
authors.forename: F X
authors.initials: FX
authors.lastname: Borruat
authors.forename: T
authors.initials: T
authors.lastname: Prado
authors.forename: M
authors.initials: M
authors.lastname: Strominger
authors.forename: N J
authors.initials: NJ
authors.lastname: Schatz
authors.forename: J S
authors.initials: JS
authors.lastname: Glaser
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000276:immunology; D012164:Retinal Diseases / Q000175:diagnosis* / Q000276:immunology; D015354:Vision, Low / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear
vernacular_title: Complications neuro-ophtalmologiques du lupus érythémateux disséminé.