Evaluation of polysulfated glycosaminoglycan for the treatment of hip dysplasia in dogs.
A double-blinded, controlled clinical study was performed to compare the response of adult dogs affected with hip dysplasia to a placebo and three different dosages of polysulfated glycosaminoglycan (PSGAG): 2.2 mg/kg, 4.4 mg/kg, and 8.8 mg/kg. Dogs were randomly assigned to treatment groups. The drug was administered intramuscularly every 3 to 5 days for a total of eight injections. Response to treatment was analyzed based on changes in lameness, range of motion (ROM), and pain on manipulation of the hip joints. Evaluation for adverse reactions included complete blood cell (CBC) count, blood urea nitrogen (BUN), creatinine, and physical examination. Data were collected on a total of 111 dogs. Eighty-four met all criteria for inclusion in the study. Dogs that were given 4.4 mg/kg of PSGAG showed the greatest improvement in orthopedic scores, whereas dogs in the placebo group showed the smallest improvement; however, the differences in clinical improvement between the four treatment groups were not statistically significant. No local or systemic adverse reactions related to the drug were observed.
de Haan
J J
JJ
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville.
Goring
R L
RL
Beale
B S
BS
D000818:Animals; D001772:Blood Cell Count / Q000662:veterinary; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006619:Hip Dysplasia, Canine / Q000188:drug therapy*; D007273:Injections, Intramuscular / Q000662:veterinary; D007794:Lameness, Animal / Q000209:etiology; D008297:Male; D010147:Pain Measurement / Q000662:veterinary; D016059:Range of Motion, Articular
D006025:Glycosaminoglycans; C013786:A73025; D003404:Creatinine