Exclusion of ferritins and iron-responsive element (IRE)-binding proteins as candidates for the hemochromatosis gene.
We have looked for genes for ferritin and its translational control protein that could account for anomalies in the expression of ferritin (FT) and the transferrin receptor in the duodenum of individuals with hemochromatosis (HC). We show that there are probably only two FTH-like sequences near the HC locus on the short arm of chromosome 6 and no FTL-like sequences. We report the cloning of the previously uncharacterized FTH sequence from 6p (FTHL15) and show that it is probably a processed pseudogene. This gene has been mapped with a panel of radiation hybrid cells to near 6p12. Additionally, we show that there are no sequences on chromosome 6p for a protein that coordinately regulates expression of ferritin and the transferrin receptor.
Zheng
H
H
Department of Biochemistry, Tufts Medical School, Boston, MA 02111.
Bhavsar
D
D
Volz
A
A
Ziegler
A
A
Drysdale
J
J
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006224:Cricetinae; D005293:Ferritins / Q000235:genetics*; D006432:Hemochromatosis / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007501:Iron / Q000378:metabolism*; D035925:Iron-Regulatory Proteins; D008969:Molecular Sequence Data; D016601:RNA-Binding Proteins / Q000235:genetics*
D035925:Iron-Regulatory Proteins; D016601:RNA-Binding Proteins; D005293:Ferritins; D007501:Iron