title: Skeletal maturation and hormonal levels after the menarche.
abstract: Skeletal maturity was studied in 82 healthy adolescent girls age between 12 and 19 who had reached the menarche from 0.5 to 5 years previously. 56 subjects (68.2%) had closed epiphyses while they were open in 26 (31.8%). The incidence of open epiphyses was 61% in the first year after the menarche and progressively decreased showing negative correlation with time elapsed since the menarche (r = 0.98, P < 0.0001). The mean +/- SE height increased from 158.7 +/- 1.3 cm in the first year after the menarche, to 162.7 +/- 1.3 cm in the fifth year after the menarche. No significant differences were seen in estradiol, estrone, testosterone, dihydrotestosterone and androstenedione levels between subjects with open or closed epiphyses while dehydroepiandrosterone and its sulfate levels were higher in the closed epiphyses group. Girls with open epiphyses at first evaluation grew about 3.5 cm in the next three years.
authors.affiliation: Department of Reproductive Physiology and Pathology, University of Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Porcu
authors.forename: S
authors.initials: S
authors.lastname: Venturoli
authors.forename: R
authors.initials: R
authors.lastname: Fabbri
authors.forename: R
authors.initials: R
authors.lastname: Paradisi
authors.forename: M
authors.initials: M
authors.lastname: Longhi
authors.forename: E
authors.initials: E
authors.lastname: Sganga
authors.forename: C
authors.initials: C
authors.lastname: Flamigni
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000728:Androgens / Q000097:blood; D001827:Body Height / Q000502:physiology; D001846:Bone Development / Q000502:physiology*; D002648:Child; D004838:Epiphyses / Q000502:physiology; D004967:Estrogens / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008572:Menarche / Q000502:physiology*; D012016:Reference Values
chemical_list: D000728:Androgens; D004967:Estrogens; D012739:Gonadal Steroid Hormones