Prednisone dose limitation of growth hormone treatment of steroid-induced growth failure.
Seven children with prednisone-induced growth failure were treated with recombinant growth hormone to improve linear growth. Six of seven patients had an increase in linear growth during therapy with recombinant growth hormone. The response to recombinant growth hormone was found to be related to the prednisone dose. When the prednisone dose was greater than 0.35 mg/kg per day, recombinant growth hormone did not increase the linear growth rate. At lower doses the response was inversely related to the amount of prednisone taken.
Rivkees
S A
SA
Pediatric Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston.
Danon
M
M
Herrin
J
J
D000293:Adolescent; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000139:chemically induced / Q000188:drug therapy*; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology
D013006:Growth Hormone; D011241:Prednisone