title: Elevation of serum M-CSF concentrations during pregnancy and ovarian hyperstimulation.
abstract: Macrophage colony stimulating factor (CSF-1 or M-CSF) is involved in haemopoiesis and probably in mouse gestation. Sexual steroids induce its production by uterine glandular epithelial cells and its receptor (product of the protooncogene C-FMS) is expressed on placental trophoblastic cells. We measured M-CSF serum levels in 119 pregnant women and in eight women undergoing ovarian hyperstimulation for in vitro fertilization. M-CSF increased early (4-8 weeks) and progressively during gestation. Its rapid elevation during the course of ovarian hyperstimulation suggests that its synthesis is probably induced by sexual steroids. This locally produced M-CSF could play a role in human pregnancy and in the pathogenesis of thrombocytopenias observed during pregnancy.
authors.affiliation: Laboratoire d'Hématologie Expérimentale, Faculté de Médecine, Limoges, France.
authors.forename: V
authors.initials: V
authors.lastname: Praloran
authors.forename: L
authors.initials: L
authors.lastname: Coupey
authors.forename: M
authors.initials: M
authors.lastname: Donnard
authors.forename: L
authors.initials: L
authors.lastname: Berrada
authors.forename: M F
authors.initials: MF
authors.lastname: Naud
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D009000:Monocytes / Q000166:cytology; D010062:Ovulation Induction; D010976:Platelet Count; D011247:Pregnancy / Q000097:blood*
chemical_list: D016173:Macrophage Colony-Stimulating Factor