[Expression of tumor suppressor gene p53 and Rb in patients with epidermoid carcinoma of the head and neck].
The suppressive effect of tumorigenicity of the tumor marker gene p53 in colon carcinomas and rb in lung carcinomas has now been shown in preceding reports. Further studies have been conducted to examine the loss of expression of p53 and rb in head and neck carcinomas. Since only a small number of cases have been analyzed, results have differed. We therefore analyzed the protein expressions of p53 and rb in 56 carcinomas of the head and neck, using immunofluorescence microscopy. Changes in DNA or RNA sequences were not analyzed. However, no correlation was found between the protein expression of p53 and rb and tumor malignancy, the grade of cellular differentiation and lymph node metastases.
Schipper
J H
JH
Universitäts-HNO-Klinik Essen.
Kelker
W
W
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016161:Genes, Retinoblastoma / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53
Die Expression der Tumorsuppressorgene p53 und Rb bei Patienten mit Plattenepithelkarzinomen im Kopf-/Halsbereich.