[The protective activity of a multicomponent vaccine made from the antigens of opportunistic microorganisms when administered orally].
Multicomponent vaccine VP-4, prepared from Streptococcus, Klebsiella, Proteus and Escherichia coli antigens, was tested for protective activity by oral administration to mice with experimental Klebsiella, Proteus and S. pneumoniae infections. Vaccine VP-4, when introduced orally (in 2-3 administrations of 2 mg), was found to produce a protective effect with respect to K. pneumoniae (the effectiveness index was equal to 5.7 and 4.3). With respect to P. vulgaris, the effectiveness index was 2.7 (immunization was made in two oral administrations of 2 mg); in pneumococcal infection preliminary oral immunization with vaccine VP-4 in two administrations in a dose of 2-4 mg produced high protective effect. Thus, immunization with vaccine VP-4, introduced orally in comparatively small doses, proved to be effective in animal models used in the experiment.
Egorova
N B
NB
Mansurova
N L
NL
Kuz'mina
L A
LA
Kaverina
K G
KG
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology*; D007114:Immunization; D007710:Klebsiella Infections / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000276:immunology*; D007928:Lethal Dose 50; D051379:Mice; D011008:Pneumococcal Infections / Q000517:prevention & control; D011512:Proteus Infections / Q000517:prevention & control; D011514:Proteus vulgaris / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity
D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined
Protektivnaia aktivnost' polikomponentnoĭ vaktsiny iz antigenov uslovnno-patogennykh mikroorganizmov pri oral'nom vvedenii.