[Determination of autoantibodies to pancreatic beta-cells, non-islet endocrine cells and fibroblasts in patients with newly detected diabetes mellitus].
The clinical onset of insulin-dependent diabetes (IDD) is characterized by the onset of circulation of autoantibodies to beta-cells. Thirty-three newly detected IDD patients and 14 newly detected patients with noninsulin-dependent diabetes mellitus were examined for autoantibodies to antigen P 64-69, to surface antigen of islet cells, to thyrocyte microsomal fraction, thyroglobulin, hypophysis, fibroblasts; the levels of circulating immune complexes were measured as well. IDD debut was found associated with the appearance of antibodies to pancreatic islet cells, thyroid, thyroglobulin, hypophysis, fibroblasts, this indicating a polyclonal activation of the immunity system. A relationship was revealed between antifibroblast antibody and anti-islet-cell antibody. Antihypophyseal antibodies were detected in 43% of patients with noninsulin dependent diabetes. Nine per cent of IDD patients and 24% of patients with noninsulin dependent condition were negative in the tests.
Smirnova
O M
OM
Chugunova
L A
LA
Zlobina
E N
EN
Brykova
S V
SV
Keda
Iu M
IuM
Kriukova
I V
IV
Pankov
Iu A
IuA
Kandror
V I
VI
Arbuzova
M I
MI
Dedov
I I
II
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013997:Time Factors
D001323:Autoantibodies
Opredelenie autoantitel k beta-kletkam podzheludochnoĭ zhelezy, neostrovkovym éndokrinnym kletkam i fibroblastam u bol'nykh s vpervye vyiavlennym sakharnym diabetom.