title: Translabyrinth electrical stimulation for the induction of immediate-early genes in the gerbil brainstem.
abstract: Brainstem immediate-early gene (IEG) protein expression was induced following applications of current to the labyrinth in unanesthetized gerbils. Electrode placement, stimulus polarity, current intensity and waveform, and anesthetics all significantly affect IEG expression patterns. Direct currents of different polarity applied across the labyrinth produced IEG expression in vestibular nuclei and inferior olivary neurons in patterns similar to those seen after hemilabyrinthectomy or hypergravity stimulation.
authors.affiliation: University of Texas Medical Branch, Department of Otolaryngology, Galveston 77555-1063.
authors.forename: G D
authors.initials: GD
authors.lastname: Kaufman
authors.forename: A A
authors.initials: AA
authors.lastname: Perachio
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D007758:Ear, Inner / Q000294:innervation*; D004558:Electric Stimulation; D015870:Gene Expression; D017781:Genes, Immediate-Early; D005849:Gerbillinae; D007150:Immunohistochemistry; D009474:Neurons / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis
chemical_list: D016760:Proto-Oncogene Proteins c-fos