EBER gene expression in Epstein-Barr virus-associated hematopoietic neoplasms.
Epstein-Barr virus encoded RNA's (EBER) are small RNA species found in cells latently infected by the virus. The physiological function of these molecules is currently a matter of speculation. Nonetheless, their presence in extremely high copy number has made it possible to reliably detect the Epstein-Barr virus by in-situ hybridization, in human tissues routinely fixed with formalin and embedded in paraffin. Such studies have enhanced our understanding of a number of hematologic malignancies, particularly Hodgkin's disease, angiocentric immunoproliferative lesions and angio-immunoblastic lymphadenopathy. In addition, sequential EBER in-situ hybridization studies on lymphoid tissues should enable oncologists to monitor the development of lymphoproliferative disorders occurring in the setting of organ transplantation, AIDS and hereditary immunodeficiencies.
Randhawa
P S
PS
Department of Pathology, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213.
Demetris
J
J
Nalesnik
M A
MA
D006402:Hematologic Diseases / Q000235:genetics* / Q000382:microbiology*; D006566:Herpesviridae Infections / Q000235:genetics* / Q000382:microbiology*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000382:microbiology*; D016601:RNA-Binding Proteins / Q000235:genetics*; D012269:Ribosomal Proteins; D014412:Tumor Virus Infections / Q000235:genetics* / Q000382:microbiology*
D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human