Regional variation in the presence of canebrake toxin in Crotalus horridus venom.
Reverse-phase HPLC was used to isolate the PLA complex neurotoxin "canebrake toxin" from the venom of Crotalus horridus from northern Florida. Individual venoms from 107 specimens of C. horridus throughout its range were investigated for the presence of the toxin. The distribution of canebrake toxin was limited to two separate regions, including a region of Louisiana, Arkansas and Oklahoma, and a separate region from southeastern South Carolina through eastern Georgia to northern Florida. Four distinct venom types were found and designated Venoms A (neurotoxic), B (hemorrhagic), A + B (neurotoxic and hemorrhagic) and C (lacking in both neurotoxic and hemorrhagic activities).
Glenn
J L
JL
Venom Research Laboratory, Veterans Affairs Medical Center, Salt Lake City, UT 84148.
Straight
R C
RC
Wolt
T B
TB
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003435:Crotalid Venoms / Q000737:chemistry* / Q000633:toxicity; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006868:Hydrolysis; D005779:Immunodiffusion; D007928:Lethal Dose 50; D051379:Mice
D003435:Crotalid Venoms