Graft-derived anti-HPA-2b production after allogeneic bone-marrow transplantation.
We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.
Taaning
E
E
Department of Clinical Immunology, State University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jacobsen
N
N
Morling
N
N
D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017713:Platelet Transfusion; D014184:Transplantation, Homologous
D016824:Antigens, Human Platelet; D007074:Immunoglobulin G