[Changes in the extracellular matrix in human mesangial proliferative glomerulonephritis].
A quantitative analysis of the components of glomerular extracellular matrix (ECM) was performed with the immunoperoxidase method (ABC method) and the computer imaging analysis system. The results demonstrate that with the development of mesangial proliferative glomerulonephritis (MsPGN), normal components of glomerular ECM (type IV collagen, laminin, fibronectin) increased markedly. In addition, interstitial collagen (type III collagen) appeared in the expanded mesangial matrix of moderate MsPGN and increased in severe MsPGN, suggesting that MsPGN is linked to the accumulation of ECM, not only the normal components, but also the interstitial collagen.
Wei
L
L
Institute of Renal Disease, Beijing Medical University.
Wang
H Y
HY
Zhang
Y K
YK
D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D007797:Laminin / Q000378:metabolism
D005353:Fibronectins; D007797:Laminin; D003094:Collagen