title: Tidal breathing flow-volume loop analysis as a test of pulmonary function in exercising horses.
abstract: The usefulness of tidal breathing flow-volume loops (TBFVL) to evaluate pulmonary function was investigated in 6 Standardbreds during treadmill exercise. Tidal breathing flow-volume loops are a graphic representation of airflow rate vs tidal volume for each individual breath. These TBFVL were obtained from horses exercising at speeds corresponding to 75 and 100% of maximum heart rate. Measurements were recorded in each horse before and after ovalbumin-induced allergic lung disease. Moderate obstructive lung disease, characterized by a significant increase in pulmonary resistance, was observed while the horses were at rest. We found that in horses with airway obstruction exercising at 75 or 100% of maximum heart rate, the quantitative indices describing TBFVL shape and size were not markedly different from those in clinically normal horses exercising at similar speeds.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
authors.forename: B A
authors.initials: BA
authors.lastname: Connally
authors.forename: F J
authors.initials: FJ
authors.lastname: Derksen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D006339:Heart Rate; D006736:Horses / Q000502:physiology*; D007114:Immunization; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D010047:Ovalbumin; D010805:Physical Conditioning, Animal; D012016:Reference Values; D012119:Respiration; D012129:Respiratory Function Tests / Q000662:veterinary; D013990:Tidal Volume
chemical_list: D010047:Ovalbumin