title: Amino- and aminomethylcholesterol derivatives with fungicidal activity.
abstract: Among a series of aminocholesterol derivatives synthesized, 7-aminocholesterol is the strongest inhibitor of yeast cell growth. Using sterol auxotrophic mutant strains, we showed that this compound inhibits cell proliferation by interfering with ergosterol biosynthesis. The sterol pattern of treated cells revealed that 7-aminocholesterol inhibits delta 8-->delta 7-sterol isomerase and delta 14-sterol reductase as morpholine inhibitors. However, the novel feature of this compound is a strong cytotoxicity to yeast.
authors.affiliation: Laboratoire de Physicochimie des Substances Naturelles, Université de La Rochelle, France.
authors.forename: L
authors.initials: L
authors.lastname: Elkihel
authors.forename: I
authors.initials: I
authors.lastname: Soustre
authors.forename: F
authors.initials: F
authors.lastname: Karst
authors.forename: Y
authors.initials: Y
authors.lastname: Letourneux
mesh_terms: D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D004875:Ergosterol / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008826:Microbial Sensitivity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism
chemical_list: C088771:7-aminocholesterol; D002784:Cholesterol; D004875:Ergosterol