Characterization of an established transplantable adenocarcinoma of the gallbladder in Syrian golden hamster.
A carcinoma of the gallbladder was transplantable in Syrian golden hamsters. The tumor was induced by subcutaneous injection of N-nitrosobis (2-oxopropyl) amine (BOP) following dissection of the common duct and preparation of a cholecysto-duodenostomy. The histology revealed a poorly differentiated adenocarcinoma. The tumor was inoculated into the cavity of the gallbladder and subcutaneous tissue of the hamster and was transplantable (uptake rate was 100%). This tumor expressed blood group-related antigens, including A, H, and P-glycoproteins. To our knowledge, this is the first report of carcinoma of the gallbladder transplantable in a laboratory animal.
Inoue
K
K
Second Department of Surgery, Nagasaki University School of Medicine, Japan.
Tomioka
T
T
Tajima
Y
Y
Fukahori
T
T
Eto
T
T
Tsunoda
T
T
Kanematsu
T
T
D000230:Adenocarcinoma / Q000139:chemically induced / Q000737:chemistry / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002273:Carcinogens; D006224:Cricetinae; D004273:DNA, Neoplasm / Q000032:analysis; D005706:Gallbladder Neoplasms / Q000139:chemically induced / Q000737:chemistry / Q000473:pathology / Q000503:physiopathology; D007150:Immunohistochemistry; D008647:Mesocricetus; D008854:Microscopy, Electron; D009602:Nitrosamines
D000951:Antigens, Neoplasm; D002273:Carcinogens; D004273:DNA, Neoplasm; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine