title: Multiple stepwise regression analysis of physiologic tension and secondary messengers in chronic burn trauma.
abstract: In this report, we have used a multiple stepwise regression analysis to determine the best derived multivariate equation between a dependent and multiple independent parameters. All parameters were derived from harvested gastrocnemius muscle subjected to chronic burn trauma. Correlations between seven different parameters were tested. Physiologic tension, calcium, adenosine 3':5' cyclic monophosphate (cAMP), inositol 1,4,5-triphosphate (IP3) and its catabolites comprised one large data matrix. From it, the various parameters were substituted as the dependent variable. The remaining parameters all comprised a multiple independent group. From such a format, the stepwise regression was run. The simultaneous co-governing of independent parameters over one dependent parameter provides a means of mathematically proving multiple correlations. Such findings provide a new perspective in interpreting chemical signalling.
authors.affiliation: Clinical Pharmacology Laboratory, Shriners Burns Research Center, Massachusetts General Hospital, Boston.
authors.forename: J F
authors.initials: JF
authors.lastname: Tomera
authors.forename: K
authors.initials: K
authors.lastname: Lilford
mesh_terms: D000818:Animals; D002056:Burns / Q000503:physiopathology*; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D004195:Disease Models, Animal; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology; D007295:Inositol Phosphates / Q000502:physiology*; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000503:physiopathology*; D012044:Regression Analysis; D015290:Second Messenger Systems
chemical_list: D007295:Inositol Phosphates; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D002118:Calcium