title: Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate.
abstract: We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance only minimally decreased. These findings suggest that 99mTc-DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption, with the nonabsorbed fraction appearing in the urine. In Fanconi Syndrome the tubular reabsorption of DMSA may also be reduced, thus explaining the poor renal uptake in this patient. A 99mTc-MDP bone scan showed faint renal uptake and diffuse high uptake mainly in the spine, demonstrating that the metabolic bone disease associated with Fanconi Syndrome can be another mechanism for poor renal visualization on bone scan.
authors.affiliation: Department of Nuclear Medicine and Internal Medicine, Seoul National University College of Medicine, Korea.
authors.forename: S E
authors.initials: SE
authors.lastname: Kim
authors.forename: J T
authors.initials: JT
authors.lastname: Cho
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Chung
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: M C
authors.initials: MC
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: C S
authors.initials: CS
authors.lastname: Koh
mesh_terms: D005198:Fanconi Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000502:physiology*; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D013131:Spine / Q000000981:diagnostic imaging / Q000378:metabolism; D004113:Succimer / Q000493:pharmacokinetics*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer; D013669:Technetium Tc 99m Medronate