title: A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines.
abstract: We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1-based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.
authors.affiliation: Research Laboratory, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.
authors.forename: R
authors.initials: R
authors.lastname: Carroll
authors.forename: J T
authors.initials: JT
authors.lastname: Lin
authors.forename: E J
authors.initials: EJ
authors.lastname: Dacquel
authors.forename: J D
authors.initials: JD
authors.lastname: Mosca
authors.forename: D S
authors.initials: DS
authors.lastname: Burke
authors.forename: D C
authors.initials: DC
authors.lastname: St Louis
mesh_terms: D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D005822:Genetic Vectors; D015497:HIV-1 / Q000235:genetics*; D066298:In Vitro Techniques; D014161:Transduction, Genetic; D014779:Virus Replication