Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives.
Alkylation of 4-hydroxycinnolines using ethyl bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
Stańczak
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A
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Lódź, Poland.
Kwapiszewski
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W
Szadowska
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Pakulska
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W
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D013239:Stereotyped Behavior / Q000187:drug effects
D002491:Central Nervous System Agents; D010793:Phthalazines; D000661:Amphetamine; D001058:Apomorphine