title: An unusual late reaction to Zyderm I injections: a challenge for treatment.
abstract: We describe a patient who, 2 1/2 years after injection with Zyderm I collagen, developed large erythematous indurated nodules and plaques at the facial injection sites. This occurred despite a prior negative skin test with the injectable material. Histopathologically, a sarcoid-like foreign-body reaction was present in the dermis and subcutaneous fat and muscles. Retesting with Zyderm I collagen on the forearm produced a positive reaction that showed, histologically, a sarcoid-like reaction similar to that which was found in the face. Various modes of therapy have failed to clear the facial lesions and disfigurement.
authors.affiliation: Department of Plastic Surgery, Rambam Medical Center, Haifa, Israel.
authors.forename: R R
authors.initials: RR
authors.lastname: Moscona
authors.forename: R
authors.initials: R
authors.lastname: Bergman
authors.forename: R
authors.initials: R
authors.lastname: Friedman-Birnbaum
mesh_terms: D000328:Adult; D001706:Biopsy; D003094:Collagen / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D008047:Lip Diseases / Q000209:etiology*; D012882:Skin Tests; D013518:Surgery, Plastic / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D003094:Collagen