title: Evidence that neuropeptide Y is a physiological signal for normal food intake.
abstract: Neuropeptide Y is the most potent orexigenic signal known. To test the hypothesis that NPY is a physiological messenger molecule for normal food intake in rats, we studied the effects of passive immunization against endogenous NPY on cumulative daily food intake in non-fasted spontaneously feeding rats. The results show that continuous central infusion of NPY antibodies markedly suppressed the nighttime and the cumulative 24 h food intake in a dose-dependent fashion. These results support the hypothesis that NPY may be a physiological signal involved in the stimulation of ingestive behavior in rats.
authors.affiliation: Department of Physiology, University of Florida College of Medicine, Gainesville 32610-0244.
authors.forename: M G
authors.initials: MG
authors.lastname: Dube
authors.forename: B
authors.initials: B
authors.lastname: Xu
authors.forename: W R
authors.initials: WR
authors.lastname: Crowley
authors.forename: P S
authors.initials: PS
authors.lastname: Kalra
authors.forename: S P
authors.initials: SP
authors.lastname: Kalra
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D002552:Cerebral Ventricles / Q000502:physiology*; D002940:Circadian Rhythm; D005247:Feeding Behavior / Q000502:physiology*; D007116:Immunization, Passive; D007263:Infusions, Parenteral; D008297:Male; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000906:Antibodies; D009478:Neuropeptide Y