Enteral formula feeds interfere with phenytoin absorption.
Two children treated for status epilepticus had low plasma phenytoin levels during enteral feeding, despite adequate oral dosage. The target range (10-20 mg/l) was achieved when feeds were stopped, or when intravenous phenytoin was used. Enteral feeding may interfere with the absorption of oral phenytoin thereby compromising seizure control.
O'Hagan
M
M
Department of Paediatrics, University Hospital of Wales, Cardiff, UK.
Wallace
S J
SJ
D000293:Adolescent; D002675:Child, Preschool; D004660:Encephalitis / Q000150:complications; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D005526:Food, Formulated / Q000009:adverse effects*; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D008297:Male; D009422:Nervous System Diseases / Q000150:complications; D010672:Phenytoin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology
D010672:Phenytoin