title: [Dysregulation of in vitro TNF-beta production in insulin-dependent diabetes mellitus].
abstract: The possible role of tumor necrosis factors (TNF) in autoimmunity led us to explore the relationship between TNF production, polymorphism of the TNF-beta gene and type one diabetes. In the diabetic group we found a low production of TNF-beta. This abnormality appeared not to be exclusively related to the TNF-beta gene and could be also due to polymorphic regulatory sequences in the major histocompatibility complex region.
authors.affiliation: Laboratoire de Biochimie, Hôpital F.-Guyon, Ile de la Réunion, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Feugeas
authors.forename: C
authors.initials: C
authors.lastname: Dosquet
authors.forename: J L
authors.initials: JL
authors.lastname: Wautier
authors.forename: C
authors.initials: C
authors.lastname: Montchamp-Moreau
authors.forename: R
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: H
authors.initials: H
authors.lastname: Caillens
mesh_terms: D000293:Adolescent; D016207:Cytokines / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000378:metabolism*; D008285:Major Histocompatibility Complex; D008297:Male; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha
vernacular_title: Dysrégulation de la production in vitro de TNF-beta au cours du diabète insulinodépendant.