title: Malignant lymphoma of the urethra: report of a case with detection of Epstein-Barr virus genome in the tumour cells.
abstract: We report a primary non-Hodgkin's B-cell lymphoma of the urethra in a 78-year-old female. Serum antibodies for Epstein-Barr virus (EBV) were negative, but there was a 40-fold increase in antibodies to EBV-associated nuclear antigen. Using PCR and in situ hybridization techniques, EBV genome was found in the tumour cell nuclei.
authors.affiliation: Department of Pathology, Osaka University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohsawa
authors.forename: K
authors.initials: K
authors.lastname: Mishima
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Hagino
authors.forename: J
authors.initials: J
authors.lastname: Doi
authors.forename: K
authors.initials: K
authors.lastname: Aozasa
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology; D004587:Electrophoresis, Agar Gel; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D005455:Fluorescent Antibody Technique; D016679:Genome, Viral; D006566:Herpesviridae Infections / Q000382:microbiology* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization / Q000379:methods; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D010641:Phenotype; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured; D014412:Tumor Virus Infections / Q000382:microbiology* / Q000473:pathology; D014523:Urethral Neoplasms / Q000276:immunology / Q000382:microbiology* / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens