Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XVIII: Oligoamines with fluorescent properties, Part B: Fluorophores in the molecular periphery.
Seventeen N,N'-benzene-1,3-dimethane and nine N,N',N''-benzene-1,3,5-trimethane derivatives with fluorescent properties have been synthesized. Three of them show antiplatelet activities (inducer collagen, IC50 Born-test) in concentrations < 10 mumol/L. They are suitable for interaction studies with biological macromolecules and synthetical and biological membranes. Structure activity relationships demonstrate that heteropolycyclic fluorophores i.e. quinoline, dibenzofurane, or carbazole are favorable substituents for this purpose.
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin.
Seidel
T
T
D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D008744:Methylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D000925:Anticoagulants; D008744:Methylamines; D010975:Platelet Aggregation Inhibitors