title: [Protective effect of 2,3-butanedione monooxime on ischemic myocardium of rats].
abstract: Effects of 2,3-butanedione monoxime (BDM), an ATPase inhibitor, on ischemia-reperfusion myocardial injury were examined in isolated working rat hearts perfused in vitro. Following cardiac arrest induced by cardioplegic solution, global ischemia was produced for 30 min. In untreated hearts, reperfusion for 45 min resulted in an incomplete recovery of cardiac pump function. When BDM was added to the cardioplegic solution up to 20 mM, the recovery of cardiac function was significantly improved average by 19%. This BDM effect can, presumably, reduce ATP losses during ischemia and like that improve recovery of cardiac function during reperfusion.
authors.forename: E L
authors.initials: EL
authors.lastname: Levitskaia
authors.forename: A N
authors.initials: AN
authors.lastname: Khatkevich
authors.forename: V I
authors.initials: VI
authors.lastname: Veksler
authors.forename: V I
authors.initials: VI
authors.lastname: Kapel'ko
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D002314:Cardioplegic Solutions; D003931:Diacetyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006323:Heart Arrest / Q000139:chemically induced; D066298:In Vitro Techniques; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats
chemical_list: D002314:Cardioplegic Solutions; C004717:diacetylmonoxime; D000251:Adenosine Triphosphatases; D003931:Diacetyl
vernacular_title: Zashchitnoe deĭstvie 2,3-butandion monoksima na ishemicheskiĭ miokardkrys.