Computer analyses suggest interactions of non-muscle filamin with lipid membranes.
It is concluded from structure predictions of the primary amino acid sequence by computer analyses that two segments of non-muscle filamin could facilitate lipid membrane attachment or anchoring. Residues 49-71 of the amino-terminal may attach to phospholipid membranes, and residues 131-155 may anchor in the hydrophobic region of lipid membranes.
Tempel
M
M
Technical University of Munich, Garching, Germany.
Goldmann
W H
WH
Isenberg
G
G
D003285:Contractile Proteins / Q000737:chemistry*; D064448:Filamins; D006801:Humans; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000737:chemistry*; D008840:Microfilament Proteins / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017421:Sequence Analysis; D012995:Solubility; D013329:Structure-Activity Relationship
D003285:Contractile Proteins; D064448:Filamins; D008563:Membrane Lipids; D008840:Microfilament Proteins