Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.
The basic strategy is described for the connection of nucleosides by guanidinium (g) linkers to provide the positively charged deoxynucleic guanidine putative antigene agents. The synthetic procedures are provided for d(gT)n. Molecular modeling of double-stranded [d(gT)10.d(Ap)10] and the triple-helical hybrids [d(Tp)10.d(Ap)10.d(gT)10] and [d(gT)10.d(Ap)10.d(gT)10] suggest modes of interaction and anticipated structural features.
Dempcy
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RO
Department of Chemistry, University of California, Santa Barbara 93106.
Almarsson
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O
Bruice
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TC
D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D015195:Drug Design; D019791:Guanidine; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry
D006146:Guanidines; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; C088820:deoxynucleic guanidine; D004247:DNA; D019791:Guanidine