title: 14-epidihydrocochlioquinone B and 14-epicochlioquinone B, antibiotics from fermentations of the ascomycete Neobulgaria pura: structure elucidation and effects on platelet aggregation.
abstract: 14-Epicochlioquinone B (1) and 14-epidihydrocochlioquinone B (2) were isolated from submerged cultures of Neobulgaria pura (Pers. ex Fr.) Petrak. 14-Epicochlioquinone B is a potent inhibitor of human and bovine platelet aggregation stimulated by different inducers. 14-Epidihydrocochlioquinone B does not inhibit the aggregation of platelets. In addition, both 1 and 2 exhibited cytotoxic and antimicrobial activities.
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Lorenzen
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: U
authors.initials: U
authors.lastname: Anders
authors.forename: H
authors.initials: H
authors.lastname: Hindermayr
authors.forename: F
authors.initials: F
authors.lastname: Hansske
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001203:Ascomycota / Q000378:metabolism*; D002417:Cattle; D003094:Collagen / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014966:Xanthenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C088862:14-epidihydrocochlioquinone B; D000900:Anti-Bacterial Agents; D010975:Platelet Aggregation Inhibitors; D014966:Xanthenes; C088861:14-epicochlioquinone B; D003094:Collagen