title: Gd-DTPA-cascade-polymer: potential blood pool contrast agent for MR imaging.
abstract: Gadolinium-DTPA (diethylenetriaminepentaacetic acid)-cascade-polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd-DTPA-polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 mumol/kg dose of each contrast agent, by using a FLASH (fast low-angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd-DTPA-polymer, enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd-DTPA-polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd-DTPA-cascade-polymer are similar to those of Gd-DTPA-polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging.
authors.affiliation: Department of Diagnostic Radiology, University of Technology Aachen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Adam
authors.forename: J
authors.initials: J
authors.lastname: Neuerburg
authors.forename: E
authors.initials: E
authors.lastname: Spüntrup
authors.forename: A
authors.initials: A
authors.lastname: Mühler
authors.forename: K
authors.initials: K
authors.lastname: Scherer
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
mesh_terms: D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D007672:Kidney Cortex / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009132:Muscles / Q000033:anatomy & histology; D009942:Organometallic Compounds; D010179:Pancreas / Q000033:anatomy & histology; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011107:Polylysine / Q000031:analogs & derivatives; D013552:Swine
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C088920:gadolinium-diethylenetriaminepentaacetic acid-cascade-polymer; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA