Anti-type I collagen antibodies in advanced phases of adjuvant arthritis.
The aim of this study was to elucidate the existence of autoantibodies directed to type I collagen as a response to connective tissue alterations that occur in inflammatory diseases. We have demonstrated the presence of antibodies to type I collagen during the time course of adjuvant arthritis, by means of the ELISA technique. These autoantibodies reached the highest levels in advanced phases of the arthritic process from 8 to 10 weeks after mycobacteria administration. The hind-paw swelling and the anti-type I collagen antibodies remained for at least 18 weeks post-induction.
Franch
A
A
Experimental Immunopathology Research Group, Faculty of Pharmacy, University of Barcelona, Spain.
Castellote
C
C
Castell
M
M
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D001169:Arthritis, Experimental / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006614:Hindlimb; D051381:Rats; D017208:Rats, Wistar
D000906:Antibodies; D003094:Collagen