title: Tn924, a chromosome-borne transposon encoding high-level gentamicin resistance in Enterococcus faecalis.
abstract: Enterococcus faecalis SF350 is a clinical isolate from Winnipeg, Canada, with high-level (MIC > 2,000 micrograms/ml) gentamicin resistance. The genetic determinant for gentamicin resistance was located on the chromosome of SF350 and could be mobilized by a coresident conjugative plasmid, pYN120. Genetic and physical analyses showed that the gentamicin resistance determinant was located on a 27-kb transposable element which was designated Tn924.
authors.affiliation: Department of Medicine, William Beaumont Hospital, Royal Oak, MI 48073.
authors.forename: L A
authors.initials: LA
authors.lastname: Thal
authors.forename: J W
authors.initials: JW
authors.lastname: Chow
authors.forename: D B
authors.initials: DB
authors.lastname: Clewell
authors.forename: M J
authors.initials: MJ
authors.lastname: Zervos
mesh_terms: D002876:Chromosomes, Bacterial / Q000502:physiology*; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects / Q000235:genetics* / Q000648:ultrastructure; D005839:Gentamicins / Q000494:pharmacology*; D010957:Plasmids; D015183:Restriction Mapping
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005839:Gentamicins