title: First recurrence analysis of 840 cutaneous melanomas: a proposal for a follow-up schedule.
abstract: OBJECTIVE
  A correct follow-up schedule for patients who underwent an excision for stage I cutaneous melanoma might allow the early detection of local and distant metastases. At present, there is no general agreement on follow-up protocols. In order to work out a follow-up guide, we have retrospectively evaluated the records of 840 stage I cutaneous melanoma patients surgically treated and followed during the postoperative period in the Division of Plastic Surgery of the University of Florence from 1975 to 1992.
  
  
  METHODS
  We evaluated the patients' records by analyzing time, pathway and site of any first recurrence in relation to the main prognostic factors such as patient sex, site, histological type and depth of invasion of each primary melanoma. A statistical analysis was performed.
  
  
  RESULTS
  To summarize, the salient results were the following: 80% of relapses occurred in the first 3 years and they occurred significantly earlier when the primary melanoma was localized in the trunk and significantly later when the melanoma was localized in the lower limbs and for < 1.5 mm lesions. The first recurrence occurred earlier by the lymphatic than by the hematic pathway regarding the overall number of patients. The hematic pathway was the most frequent (with respect to the overall percentage of hematic metastases) for the melanomas localized in the head and neck region and for lentigo malignant melanomas, whereas the lymphatic pathway was most frequent for melanomas of the lower limbs and > 3 mm in thickness.
  
  
  CONCLUSIONS
  We suggest a follow-up schedule taking into consideration the postoperative behavior of stage I cutaneous melanoma patients (in terms of time and pathway of the first recurrence) in relation to the site and depth of invasion of the tumor.
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Martini
authors.forename: P
authors.initials: P
authors.lastname: Brandani
authors.forename: C
authors.initials: C
authors.lastname: Chiarugi
authors.forename: U M
authors.initials: UM
authors.lastname: Reali
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012737:Sex Factors; D012878:Skin Neoplasms / Q000473:pathology*; D013997:Time Factors