Neuroanatomical divergence between two substrains of C57BL/6J inbred mice entails differential radial-maze learning.
Compared to the parental strain C57BL/6J, male mice from the mutated substrain C57BL/6JNmg show smaller hippocampal intra- and infrapyramidal mossy fiber projections and a correlated inability to master a simple spatial radial-maze task. Possibly, these two substrains differ for only one single gene, making them a valuable model to investigate the physiological pathways leading from genotype to neurobehavioral phenotype.
Jamot
L
L
Génétique, Neurogénétique et Comportement, URA 1294 C.N.R.S., UFR Biomédicale des Saints-Pères, Université René Descartes (Paris V), France.
Bertholet
J Y
JY
Crusio
W E
WE
D000818:Animals; D005838:Genotype; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D010641:Phenotype; D017966:Pyramidal Cells / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D013045:Species Specificity