[Analysis of the immunomodulating action of SK in mice of various strains].
Peculiarities of immunomodulative action of different mice breeds' SK have been determined by changes of activity level of 5'-nucleotidase in macrophages from peritoneal exudate (MPE) and by changes of animals' sensitivity to staphylococcus infection. It has been established that the character of SK influence on activity level of 5'-nucleotidase in MPE and resistance depends on dose, type of administration and the mice breed. Revealed by hypodermic injection, dependence between the activity of 5'-nucleotidase in MPE and sensitivity to staphylococcus infection, whose character was determined by animals' genotype, had straight character in C57Bl/6 mice, and reverse character in CBA mice.
Zlishcheva
E I
EI
Kirillicheva
G B
GB
Shurygin
A Ia
AIa
Baturina
I G
IG
Ratgauz
G L
GL
D015720:5'-Nucleotidase / Q000097:blood; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005838:Genotype; D007113:Immunity, Innate; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013203:Staphylococcal Infections / Q000276:immunology
D000276:Adjuvants, Immunologic; D015720:5'-Nucleotidase
Analiz immunomoduliruiushchego deĭstviia SK u musheĭ raznykh liniĭ.