Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease.
Apolipoprotein E (apoE) is a protein involved in the transport of lipids and a component of Alzheimer's disease (AD) plaques. There are three common alleles of the apoE gene, designated epsilon 2, epsilon 3 and epsilon 4. An association between familial and sporadic AD and the epsilon 4 allele was recently reported. We have investigated Swedish Alzheimer patients and controls. The epsilon 4 allele frequency in familial and sporadic cases and in controls was 47, 22 and 18%, respectively. There was no significant difference between sporadic AD and controls but in familial cases the increased epsilon 4 allele frequency previously reported was confirmed.
Lannfelt
L
L
Karolinska Institute, Department of Geriatric Medicine, Huddinge, Sweden.
Lilius
L
L
Nastase
M
M
Viitanen
M
M
Fratiglioni
L
L
Eggertsen
G
G
Berglund
L
L
Angelin
B
B
Linder
J
J
Winblad
B
B
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism*; D006801:Humans; D012306:Risk
D001057:Apolipoproteins E