CD8-positive B-cell chronic lymphocytic leukemia. A report of two cases.
Most B-cell chronic lymphocytic leukemias and a small normal subset of B lymphocytes express the T-cell-associated CD5 antigen; expression of other T-cell antigens has been reported only rarely. The authors report two cases of typical B-cell chronic lymphocytic leukemia, seen during 1 year, in which two-color flow cytometric analysis documented expression of the T-cell-associated CD8 antigen by the monoclonal B cells. Genotypic studies showing immunoglobulin but not T-cell-receptor gene rearrangements confirmed the B-cell origin of the neoplastic cells. The true frequency of the CD8-positive B-cell chronic lymphocytic leukemia, any clinical implications, and the possibility of a normal subset of CD5-positive CD8-positive B cells remain to be determined.
Koelliker
D D
DD
Department of Pathology and Laboratory Medicine, University of Cincinnati, Ohio.
Steele
P E
PE
Hurtubise
P E
PE
Flessa
H C
HC
Sheng
Y P
YP
Swerdlow
S H
SH
D000368:Aged; D001773:Blood Cells / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D005838:Genotype; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D016827:CD8 Antigens