title: Efficacy of a resorbable hydrogel barrier, oxidized regenerated cellulose, and hyaluronic acid in the prevention of ovarian adhesions in a rabbit model.
abstract: OBJECTIVE
  To compare the efficacy of a resorbable hydrogel material with oxidized regenerated cellulose and hyaluronic acid in an ovarian adhesion model.
  
  
  METHODS
  Controlled, blinded, and randomized study involving female rabbits.
  
  
  METHODS
  Academic research environment.
  
  
  METHODS
  A water-soluble hydrogen precursor was applied to the ovary as a liquid and converted to a hydrogel by exposure to long wavelength ultraviolet light, a 0.4% solution of hyaluronic acid was applied to the ovary, or an oxidized regenerated cellulose patch was applied to the ovary after wedge resectioning.
  
  
  METHODS
  Extent and severity of adhesion formation.
  
  
  RESULTS
  Application of the hydrogel reduced adhesion formation by 88%. Neither oxidized regenerated cellulose nor hyaluronic acid reduced adhesion formation.
  
  
  CONCLUSIONS
  The photopolymerized, resorbable hydrogel material is highly effective for the reduction of periovarian adhesions in this model.
authors.affiliation: Department of Biomedical Engineering, University of Texas, Austin 78712.
authors.forename: J L
authors.initials: JL
authors.lastname: Hill-West
authors.forename: S M
authors.initials: SM
authors.lastname: Chowdhury
authors.forename: R C
authors.initials: RC
authors.lastname: Dunn
authors.forename: J A
authors.initials: JA
authors.lastname: Hubbell
mesh_terms: D000818:Animals; D002482:Cellulose / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010049:Ovarian Diseases / Q000473:pathology / Q000517:prevention & control*; D010053:Ovary / Q000473:pathology; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011817:Rabbits; D012038:Regeneration; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D002482:Cellulose; D006820:Hyaluronic Acid