A characteristic sequence of trisomies starting with trisomy 7 in benign thyroid tumors.
The cytogenetic results from a series of 113 thyroid hyperplasias and adenomas are reported; 15 showed clonal karyotypic alterations. In addition to a group showing translocations involving 19q13, another subset of lesions characterized by polysomies can be found. Based on our own cases belonging to this subset and a review of the cases reported in the literature, we conclude that the characteristic feature of this group is a sequence that always starts with trisomy 7, but that sometimes even leads to chromosome numbers in the hypertriploid range. This subset of thyroid tumors may be an example of a more common genetic pathway in human solid tumors.
Belge
G
G
Zentrum für Humangenetik und genetische Beratung, Universität Bremen, Germany.
Thode
B
B
Rippe
V
V
Bartnitzke
S
S
Bullerdiek
J
J
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics*; D014314:Trisomy