title: No effect of insertion/deletion polymorphism at the ACE locus on normal blood pressure level or variability.
abstract: Angiotensin I-converting enzyme (ACE) cleaves angiotensin I to angiotensin II, which is the active component in the renin-angiotensin system (RAS). We have studied an insertion/deletion polymorphism in DNA at the ACE locus. In three different series comprising 140, 90 and 136 unrelated individuals we found no evidence of association between genotypes in this insertion/deletion (I/D) polymorphism and level of systolic or diastolic blood pressure. In two series of 130 and 88 monozygotic (MZ) twin pairs, respectively, there was no difference between genotypes in within-pair variation in systolic or diastolic blood pressure. Thus, in these series of healthy people, neither "level gene" nor "variability gene" effects of this insertion/deletion polymorphism were observed.
authors.affiliation: Institute of Medical Genetics, University of Oslo, Norway.
authors.forename: K E
authors.initials: KE
authors.lastname: Berge
authors.forename: K
authors.initials: K
authors.lastname: Berg
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D002872:Chromosome Deletion; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014430:Twins, Monozygotic
chemical_list: D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A