Respiratory virus infection of mice provokes a permanent humoral immune response.
We have observed that respiratory virus infection of mice provokes an extremely persistent humoral immune reaction, due to a long-sustained population of antibody-secreting cells in the bone marrow. Theories of humoral immunity that strongly distinguish primary and secondary reactions thus may not adequately describe the immune response to respiratory viruses.
Hyland
L
L
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Sangster
M
M
Sealy
R
R
Coleclough
C
C
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral