title: [Neonatal cardiac failure secondary to hypocalcemia caused by maternal vitamin D deficiency].
abstract: BACKGROUND
  Heart failure is a rare manifestation of neonatal hypocalcemia. This paper describes such a case resulting from maternal vitamin D deficiency.
  
  
  METHODS
  A full-term boy, born in December after a normal pregnancy, was admitted at the age of 6 weeks because of dyspnea that appeared during suckling. Examination showed heart failure. Electrocardiogram showed that the corrected QT-interval was lengthened (0.54 s, normal < 0.45 s). Echocardiogram showed dilated, hypokinetic myocardiopathy. His serum calcium concentration was low (1.40 mmol/l) and phosphate was high (2.8 mmol/l); his alkaline phosphatase was 513 Ul/l. His blood PTH concentration was high (120 pg/ml) and his 25 (OH) D was low (5 ng/ml). The patient was given calcium (1 g/m2/day) and 1.25 (OH)2 D (2 micrograms/day orally). His serum calcium returned to normal within 4 days, and his cardiac abnormality was resolved within 3 months. His mother's blood 25 (OH) D concentration was very low (3 ng/ml), 6 weeks after birth.
  
  
  CONCLUSIONS
  Neonatal hypocalcemia appears to have been compounded in this case by a maternal vitamin D deficiency. Hence, all pregnant women at risk of deficiency should be given vitamin D.
authors.affiliation: Unité d'Endocrinologie, CNRS URA, Hôpital et Faculté Necker-Enfants Malades, Paris.
authors.forename: I
authors.initials: I
authors.lastname: Memmi
authors.forename: R
authors.initials: R
authors.lastname: Brauner
authors.forename: D
authors.initials: D
authors.lastname: Sidi
authors.forename: S
authors.initials: S
authors.lastname: Sauvion
authors.forename: J C
authors.initials: JC
authors.lastname: Souberbielle
authors.forename: M
authors.initials: M
authors.lastname: Garabedian
mesh_terms: D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000517:prevention & control; D014807:Vitamin D / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications* / Q000151:congenital / Q000517:prevention & control
chemical_list: D014807:Vitamin D; D010758:Phosphorus; D002118:Calcium
vernacular_title: Insuffisance cardiaque néonatale secondaire à une hypocalcémie par carence maternelle en vitamine D.