[Interaction of tamoxifen with cytosol estradiol receptors in myoma and histologically unchanged myometrium].
The relative binding affinity of nonsteroidal antiestrogen tamoxifen to the cytosol estradiol receptors of hyperplastic and unaltered myometria in patients with leiomyoma has been studied. Relative binding affinity of tamoxifen in tumor tissues exceeded one in normal myometrium.
Kareva
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EN
Kostyleva
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OI
D003600:Cytosol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism*; D011959:Receptors, Estradiol / Q000378:metabolism*; D012016:Reference Values; D013629:Tamoxifen / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D011959:Receptors, Estradiol; D013629:Tamoxifen
Vzaimodeĭstvie tamoksifena s tsitozol'nymi retseptorami éstradiola miomy i gistologicheski neizmenennogo miometriia.