SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin.
SB-202742 [1], an anacardic acid derivative possessing beta-lactamase inhibitory activity, has been isolated from a hexane extract of the plant, Spondias mombin. Its isolation, structure determination, and biological activity are reported herein.
Coates
N J
NJ
SmithKline Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
Gilpin
M L
ML
Gwynn
M N
MN
Lewis
D E
DE
Milner
P H
PH
Spear
S R
SR
Tyler
J W
JW
D048729:Anacardic Acids; D002851:Chromatography, High Pressure Liquid; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010936:Plant Extracts / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D012459:Salicylates / Q000302:isolation & purification* / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors
D048729:Anacardic Acids; D010936:Plant Extracts; D012459:Salicylates; D065093:beta-Lactamase Inhibitors; C088926:SB 202742