title: Fungal metabolites. XVI. Structures of new peptaibols, trichokindins I-VII, from the fungus Trichoderma harzianum.
abstract: New peptaibols, trichokindins I-VII, have been isolated from the fungus Trichoderma harzianum. Their structures were characterized by spectrometric methods. Trichokindins, which are 18-residue peptides containing one to three isovaline residues, were found to induce Ca(2+)-dependent catecholamine secretion from bovine adrenal medullary chromaffin cells.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: M
authors.initials: M
authors.lastname: Sanekata
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Enoki
authors.forename: G
authors.initials: G
authors.lastname: Fuse
authors.forename: M
authors.initials: M
authors.lastname: Kanai
authors.forename: P J
authors.initials: PJ
authors.lastname: Rudewicz
authors.forename: E
authors.initials: E
authors.lastname: Tachikawa
mesh_terms: D000313:Adrenal Medulla / Q000166:cytology* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism; D002417:Cattle; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014242:Trichoderma / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D010455:Peptides; D002118:Calcium