Peroxidation potential of rat thymus during development and involution.
The thymus of rats of ages between 1 and 7 months was homogenised and subjected to oxidative stress induced by iron salts. Lipid peroxidation, protein thiols and glutathione status were evaluated. The thymus of rats of 1 month of age exhibited lower susceptibility to the radical attack with respect to the thymus of rats between 3 and 7 months of age. This susceptibility was correlated with the content of polyunsaturated fatty acids and of lipophylic chain-breaking antioxidants.
Galli
M C
MC
Dipartimento di Biochemica, Università di Bologna, Italy.
Cabrini
L
L
Caboni
F
F
Cipollone
M
M
Landi
L
L
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances; D013950:Thymus Gland / Q000254:growth & development / Q000378:metabolism*
D005227:Fatty Acids; D005609:Free Radicals; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione