[Lymphocytes with receptors to streptococcal polysaccharide group A in the thymus of rheumatism patients. Change in the response of normal thymocytes to adenosine, theophylline and decantate].
With the help of immunomodulators (adenosine, theophylline, levamisole) and decantat of 3-hour culture of normal thymocytes, the features of thymocytes with the receptor for polysaccharide of streptococcus group A(A-PSC) (R = PSC+cells) in patients with rheumatism. It has been established that in patients' thymus the quantity of lymphocytes, able to express R-PSC (predecessors of R = PSC + cells) decreased under the influence of theophylline and adenosine. The predecessors of R = PSC+thymocytes in the majority of patients with rheumatism are areactive to decantat action. Moreover R = PSC+cells in comparison with normal ones lose this receptors under it's influence.
Gnezditskaia
E V
EV
Bazanova
E A
EA
Bukhova
V P
VP
D000241:Adenosine / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000293:Adolescent; D002478:Cells, Cultured; D002648:Child; D006801:Humans; D007978:Levamisole / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000378:metabolism*; D012016:Reference Values; D012216:Rheumatic Diseases / Q000097:blood / Q000188:drug therapy*; D013297:Streptococcus pyogenes; D013806:Theophylline / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; C036112:streptococcal polysaccharide group A; D007978:Levamisole; D013806:Theophylline; D000241:Adenosine
Limfotsity s retseptorami k polisakharidu streptokokka gruppy A v timuse bol'nykh revmatizmom, izmenenie ikh reaktsii na adenozin, teofillin i dekantat normal'nykh timotsitov.