Primary central nervous system Burkitt's lymphoma presenting as Guillain-Barré syndrome.
A rare case of CNS Burkitt's lymphoma presenting as acute Guillain-Barré syndrome is presented. A 6-year-old previously healthy female presented with acute onset of limb and truncal weakness, involvement of ocular and bulbar nerves, and areflexia. The clinical diagnosis of Guillain-Barré syndrome prompted treatment with intravenous gammaglobulin with no response. A lumbar puncture following revealed marked pleocytosis, elevated protein, and decreased glucose. Immunological, cytological, and molecular studies of these cells confirmed the diagnosis of Burkitt's lymphoma IgM, kappa with t(8;14) and rearrangement of the J and kappa immunoglobulin chains. Aggressive systemic and intrathecal chemotherapy were started and within 5 days remission was achieved. The child is in complete remission 2 years from diagnosis. Although very rare, CNS lymphoma should be taken into account in every patient presenting with the clinical features of acute polyneuropathy.
Toren
A
A
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Mandel
M
M
Shahar
E
E
Rimmoni
E
E
Roizin
H
H
Neuman
Y
Y
Brok-Simoni
F
F
Mark
Z
Z
Biniaminov
M
M
Rosenthal
E
E
D000208:Acute Disease; D002051:Burkitt Lymphoma / Q000175:diagnosis*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis*; D002648:Child; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D011129:Polyradiculoneuropathy / Q000175:diagnosis*