title: 3H-naloxone binding in brain regions of normotensive Wistar, spontaneously hypertensive and renal hypertensive rats.
abstract: In order to study the role of opioid receptors in two models of experimental hypertension the binding of 3H-naloxone to membranes prepared from discrete brain regions and spinal cord was determined. Renal hypertensive rats (RHR) were found to have a greater density of 3H-naloxone binding sites in the hippocampus and hypothalamus when compared to spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NR). The apparent dissociation constant (Kd) for 3H-naloxone binding did not differ between groups.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Medical Academy, Warsaw, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Widy-Tyszkiewicz
authors.forename: J
authors.initials: J
authors.lastname: Kotapski
authors.forename: A
authors.initials: A
authors.lastname: Czlonkowski
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D006977:Hypertension, Renal / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D012016:Reference Values; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D014316:Tritium; D009270:Naloxone