title: An immunohistochemical study of Warthin-Finkeldey cells in measles.
abstract: An autopsy case of an 18 month old male infant with measles infection is reported. An autopsy revealed generalized lymphadenopathy, splenomegaly and hyperplastic thymus. Histologically, there were many Warthin-Finkeldey cells (WFC) in hyperplastic lymphoid tissues. Although viral particles and inclusions were not detected electronmicroscopically, the infection of measles virus was detected in WFC by immunofluorescent technique using anti-measles antibody. Warthin-Finkeldey cells were morphologically and immunohistochemically divided into two groups. The first type was WFC appearing in the germinal centers of lymphoid tissue, revealing many large nuclei and B cell markers. The second type was WFC appearing in the interfollicular areas and thymus, showing many small hyperchromatic nuclei and T cell markers. The data indicate that there might be a morphologic and immunophenotypic heterogeneity in WFC.
authors.affiliation: Department of Pathology, Fukushima Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Sakuma
authors.forename: H
authors.initials: H
authors.lastname: Wakasa
mesh_terms: D001344:Autopsy; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008457:Measles / Q000473:pathology*