Trisomy 18 and trisomy 21 mosaicism in a Down's syndrome patient.
A male child with typical features of Down's syndrome and mosaicism of two trisomic cell lines, trisomy 18 (84%) and trisomy 21 (16%), is reported. Non-disjunction or anaphase lag of chromosomes 18 and 21 could be the cause.
Thomas
I M
IM
Department of Anatomy, St John's Medical College, Bangalore, India.
Sayee
R
R
Shavanthi
L
L
Sridevi
H
H
D000705:Anaphase; D002675:Child, Preschool; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D008938:Mitosis; D009030:Mosaicism; D009630:Nondisjunction, Genetic; D014314:Trisomy