title: [Frequency potentiation mechanisms of cyclic AMP-dependent responses of snail neurons].
abstract: Intracellular injection of cAMP with the help of microiontophoresis (5-40 nA, 1-10 s) into land snail neurons induces rapid membrane depolarization. Action potentials have not influence on the following cAMP-responses. When the intervals between cAMP-injections are less than 5 minutes the effect of frequency potentiation of cAMP-responses is obtained. The experiments with cAMP-injection from two different barrels of multibarreled microelectrode show that a change of the microelectrode barrels during repetitive injections causes an abolition of the frequency potentiation effect of cAMP-responses. The results suggest that the frequency potentiation effect of cAMP-responses may be explained by peculiarities of microiontophoresis.
authors.forename: O V
authors.initials: OV
authors.lastname: Borisova
authors.forename: E I
authors.initials: EI
authors.lastname: Solntseva
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitskiĭ
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D006372:Helix, Snails; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D008846:Micromanipulation; D009474:Neurons / Q000187:drug effects*
chemical_list: D000242:Cyclic AMP
vernacular_title: Izuchenie mekhanizmov chastotnoĭ potentsiatsii tsAMP-zavisimykh otvetov neĭronov vinogradnoĭ ulitki.