The effect of electromagnetic field exposure on the formation of DNA single strand breaks in human cells.
Electromagnetic fields (EMF) have been reported to be associated with human cancers in a number of epidemiological studies. Agents that are associated with cancer affect DNA in an adverse manner. This is a report of a DNA damage study in human cells exposed to EMFs. Single strand breaks in DNA are proposed to be necessary events in both mutagenesis and carcinogenesis. The single cell gel assay is a sensitive and accurate technique that was used in this study for single strand break detection. The EMF exposure system used here appeared to have no direct effect on DNA damage induction in a series of experiments. Moreover, EMF did not have a significant effect in potentiating DNA damage in cells treated with oxidative stresses.
Fairbairn
D W
DW
Department of Microbiology, Brigham Young University, Provo, Utah 84602.
O'Neill
K L
KL
D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000528:radiation effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D015894:Genome, Human; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide; D008856:Microscopy, Fluorescence
D004277:DNA, Single-Stranded; D006861:Hydrogen Peroxide