title: Expression of astroglial nerve growth factor in damaged brain.
abstract: This article provides an overview of different brain insults leading to induction of astroglial NGF expression. It discusses mechanisms of induction of astroglial NGF in a damaged brain and a possible role of its expression in pathophysiology of Alzheimer's disease. It emphasizes that the pharmacological manipulation of astroglial production of NGF may serve as a possible therapeutic strategy to ameliorate the pathological changes occurring after brain damage.
authors.affiliation: Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Oderfeld-Nowak
authors.forename: A
authors.initials: A
authors.lastname: Bacia
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D009414:Nerve Growth Factors / Q000096:biosynthesis*
chemical_list: D009414:Nerve Growth Factors