In vitro vitamin E and selenium supplementation improves neutrophil-mediated functions and monocyte chemoattractant protein-1 production in the elderly.
The in vitro effects of vitamin E and selenium on either polymorphonuclear cell (PMN)-mediated chemotaxis and phagocytosis or monocyte chemoattractant protein-1 (MCP-1) production in 21 well-nourished elderly donors were evaluated. Results show that, before treatment, old subjects were characterized by a decrease of both PMN functions and cytokine (CK) release. By contrast, in vitro vitamin E and selenium supplementation was able to enhance significantly the depressed PMN activities and MCP-1 synthesis. These findings suggest a role for both nutrients in the modulation of impaired phagocyte responsiveness during senescence.
Ventura
M T
MT
Istituto di Medicina Clinica, University of Bari Medical Faculty, Italy.
Serlenga
E
E
Tortorella
C
C
Antonaci
S
S
D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000096:biosynthesis*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D012643:Selenium / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D018932:Chemokine CCL2; D002630:Chemotactic Factors; D014810:Vitamin E; D012643:Selenium