Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1.
Glycoprotein C (gC)-negative clinical isolates of herpes simplex virus type 1 (HSV-1) are very rare. An HSV-1 strain (TN-1), isolated from a patient with herpetic keratitis, exhibited a gC-negative phenotype. While a gC-negative mutant showed reduced pathogenicity and failed to induce herpetic stromal keratitis (HSK) in a previously reported mouse model, TN-1 induced HSK in mice comparable to RTN-1-20-3, a gC-positive recombinant virus derived from TN-1. Virus growth in eyes and brains and the mortality of TN-1-inoculated mice were equal to or higher than those of RTN-1-20-3-inoculated mice.
Sakai
Y
Y
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Minagawa
H
H
Ishibashi
T
T
Inomata
H
H
Mori
R
R
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001921:Brain / Q000382:microbiology; D002460:Cell Line; D003319:Corneal Stroma / Q000382:microbiology*; D018259:Herpesvirus 1, Human / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D016849:Keratitis, Herpetic / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D012668:Trigeminal Ganglion / Q000382:microbiology
D000914:Antibodies, Viral