Interference by Parvolex with chloride estimation by the Ag/AgCl method.
We demonstrate significant interference by Parvolex (acetylcysteine) with the Ag/AgCl method for chloride estimation. A study of four patients who had taken a paracetamol overdose and been treated with Parvolex implied this interference, and an in vitro study confirmed it. The interference was shown to decline upon storage of the serum at a similar rate in both the patient and in vitro studies. Suggested mechanism for these phenomena are given.
Bishell
G P
GP
Department of Biochemistry, Morriston Hospital, Wales, UK.
Lewis
H
H
Rooke
R A
RA
Davies
H R
HR
D001786:Blood Glucose / Q000032:analysis; D002712:Chlorides / Q000097:blood*; D003553:Cystine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004573:Electrolytes / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D018030:Silver Compounds; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D002712:Chlorides; D004573:Electrolytes; D018030:Silver Compounds; D003553:Cystine; D014508:Urea; C037548:silver chloride; C030905:N-monoacetylcystine