Interstitial chemotherapy with sustained-release polymer systems for the treatment of malignant gliomas.
Olivi
A
A
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Brem
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001672:Biocompatible Materials; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000601:surgery; D002330:Carmustine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity; D017024:Chemotherapy, Adjuvant; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D003652:Decanoic Acids; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004337:Drug Carriers; D004343:Drug Implants; D004354:Drug Screening Assays, Antitumor; D005909:Glioblastoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D005910:Glioma / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011091:Polyesters; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D016879:Salvage Therapy; D016019:Survival Analysis
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003652:Decanoic Acids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004343:Drug Implants; D011091:Polyesters; C055401:decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer; D002330:Carmustine