A case of pemphigus foliaceus after interferon alpha-2a therapy.
We present here a 63-year-old man with chronic hepatitis C who developed bullous lesions and anti-intercellular antibodies when he received interferon (IFN) alpha-2a, 9 MU subcutaneously, 3 times a week for 3 months. The direct immunofluorescence was consistent with pemphigus features. The indirect immunofluorescence showed negative before IFN treatment, but it became positive after 3 months. The immunoblot study showed no specific bands. This is the third report of the bullous lesions with anti-intercellular antibodies following IFN therapy.
Niizeki
H
H
Section of Dermatology, Kitasato Institute Hospital, Tokyo, Japan.
Inamoto
N
N
Nakamura
K
K
Tsuchimoto
K
K
Hashimoto
T
T
Nishikawa
T
T
D001323:Autoantibodies / Q000032:analysis; D006526:Hepatitis C / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011994:Recombinant Proteins
D001323:Autoantibodies; D007074:Immunoglobulin G; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins