[The optimization of the technology for culturing vaccinal strains of Shigella flexneri].
The drainage-filling cultivation process for three Shigella flexneri vaccine strains in small-capacity fermenters has been developed. The study has shown that after hydroxylamine treatment the yield of the antigenic component, calculated per 1000 million microbial cells, is tenfold higher in comparison with the traditional method.
Basnak'ian
I A
IA
Miriasova
L V
LV
Sokolova
T V
TV
Ian'kova
M M
MM
Kalina
N G
NG
Elkina
S I
SI
Sergeev
V V
VV
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000302:isolation & purification / Q000633:toxicity; D001428:Bacterial Vaccines / Q000276:immunology / Q000302:isolation & purification* / Q000633:toxicity; D001431:Bacteriological Techniques / Q000295:instrumentation; D003470:Culture Media; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D051379:Mice; D012763:Shigella flexneri / Q000254:growth & development* / Q000276:immunology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D003470:Culture Media
Optimizatsiia tekhnologii kul'tivirovaniia vaktsinal'nykh shtammov Shigella flexneri.