title: Holt-Oram syndrome is a genetically heterogeneous disease with one locus mapping to human chromosome 12q.
abstract: Holt-Oram syndrome (HOS) is an autosomal dominant condition affecting the heart and upper limbs. We have sought to identify the location of this gene using microsatellite DNA markers in a linkage study. Of seven families analysed, five show linkage between HOS and markers on chromosome 12q. But the two remaining families, phenotypically indistinguishable from the others, do not show this linkage. Analysis with the computer program HOMOG indicates that HOS is a heterogeneous disease. Our analysis places one HOS locus in a 21 cM interval in the distal region of chromosome 12q. The localization of a gene for HOS, reported here, represents an important step towards a better understanding of limb and cardiac development.
authors.affiliation: Centre for Medical Genetics City Hospital, Nottingham, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Terrett
authors.forename: R
authors.initials: R
authors.lastname: Newbury-Ecob
authors.forename: G S
authors.initials: GS
authors.lastname: Cross
authors.forename: I
authors.initials: I
authors.lastname: Fenton
authors.forename: J A
authors.initials: JA
authors.lastname: Raeburn
authors.forename: I D
authors.initials: ID
authors.lastname: Young
authors.forename: J D
authors.initials: JD
authors.lastname: Brook
mesh_terms: D000015:Abnormalities, Multiple / Q000145:classification / Q000235:genetics*; D001132:Arm / Q000002:abnormalities*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003434:Crossing Over, Genetic; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D005799:Genes, Dominant; D005819:Genetic Markers; D006228:Hand Deformities, Congenital / Q000145:classification / Q000235:genetics*; D006330:Heart Defects, Congenital / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D013577:Syndrome
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers