Naphtyl methyl imidazoline (NMI) membranes interactions: NMR study and evaluation of possible radioprotective consequences.
The interactions of the radioprotective molecule Naphtyl methyl imidazoline (NMI) with membranes have been studied using biophysical and biochemical methods. 1H, 2H and 31P-NMR methods showed a strong interaction with the deep part of the layer of model membranes inducing the formation of a new membrane compartment. These properties are not involved in the radioprotection effect of NMI which is more probably due to its vasoconstrictive properties.
Debouzy
J C
JC
CRSSA 24, La Tronche, France.
Chancerelle
Y
Y
Fauvelle
F
F
Vezin
H
H
Marroncles
C
C
Cruz
C
C
Maillet
J M
JM
D006801:Humans; D066298:In Vitro Techniques; D008566:Membranes / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D008567:Membranes, Artificial; D009278:Naphazoline / Q000737:chemistry*; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D008567:Membranes, Artificial; D011837:Radiation-Protective Agents; D009278:Naphazoline