Reduction in dentine apposition in rat molars by a high-sucrose diet.
The effects of high-sucrose and high-starch diets on dentine apposition were examined. One group of young Wistar rats (20 rats) received a high-sucrose (43%) diet; for the high-starch group (16 rats), sucrose was replaced with potato flour. The control group (18 rats) received standard laboratory rat food. The onset of dentine formation was marked with tetracycline. After 5 weeks lower molars were sectioned sagittally, and the areas of the dentine apposition and those of the dentinal caries were quantified. Dentine apposition was independent of sex. The high-sucrose diet reduced dentine apposition and induced caries progression. A negative correlation between dentine apposition and caries progression in the molars was found. This study suggests that a high-sucrose diet itself reduces primary dentine apposition.
Tjäderhane
L
L
Institute of Dentistry, University of Oulu, Finland.
Hietala
E L
EL
Larmas
M
M
D000818:Animals; D001835:Body Weight; D003731:Dental Caries / Q000209:etiology / Q000473:pathology; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D003750:Dental Fissures / Q000209:etiology / Q000473:pathology; D003804:Dentin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003810:Dentinogenesis / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005260:Female; D008297:Male; D008963:Molar; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013213:Starch / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D013395:Sucrose; D013213:Starch