The theory of genotypic selection: predicting the direction of evolution as a consequence of G:U base pairing and the existence of non-pathogenic strains of HIV-1.
One aspect of the Theory of Genotypic Selection states that G:U base pairs are selected for function and structure. RNA secondary structures stabilised by G:U base pairs are suggested to be involved in the evolution of attenuated strains of polio virus. Asymmetric mutations (C-->U and A-->G) and convergent evolutionary solutions are explained as a direct consequence of G:U base pairing. The possibility of a naturally occurring attenuated strain of HIV-1 is predicted.
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Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08903.
D001482:Base Composition; D001483:Base Sequence; D005075:Biological Evolution; D005544:Forecasting; D005838:Genotype; D006147:Guanine / Q000032:analysis*; D015497:HIV-1 / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation; D017955:Poliovirus / Q000235:genetics; D012641:Selection, Genetic; D013329:Structure-Activity Relationship; D014529:Uridine / Q000032:analysis*; D014613:Vaccines, Attenuated
D014613:Vaccines, Attenuated; D006147:Guanine; D014529:Uridine