title: [Functional spectroscopy: the limits and potentials of a new method for the study of brain activation with MR tomography].
abstract: The possibility of examining brain activity by means of localised spectroscopy was studied in relation to its neurological basis. Measurements on 18 normals during optical stimulation showed an improvement in signal to noise ratio compared with functional imaging of almost one order of magnitude. Time dependent measurements during stimulation by a 500 ms light impulse showed definite delay of increased blood flow when compared with oxygen utilisation. The excellent signal to noise ratio and the inherent stability of the method permits reliable detection of weak effects such as are caused by finger tapping or electrical stimulation.
authors.affiliation: Radiologische Klinik, Abteilung Röntgendiagnostik, Albert-Ludwigs-Universität, Freiburg.
authors.forename: J
authors.initials: J
authors.lastname: Hennig
authors.forename: J
authors.initials: J
authors.lastname: Laubenberger
authors.forename: T
authors.initials: T
authors.lastname: Ernst
authors.forename: O
authors.initials: O
authors.lastname: Speck
authors.forename: E
authors.initials: E
authors.lastname: Feifel
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: M
authors.initials: M
authors.lastname: Langer
mesh_terms: D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D004558:Electric Stimulation / Q000379:methods; D004562:Electrocardiography; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D010775:Photic Stimulation / Q000379:methods; D012016:Reference Values; D013997:Time Factors
vernacular_title: Funktionelle Spektroskopie: Grenzen und Möglichkeiten einer neuen Methode zur Untersuchung der Hirnaktivierung mit Kernspintomographie.