title: Significant increase in trisomy 21 in Berlin nine months after the Chernobyl reactor accident: temporal correlation or causal relation?
abstract: OBJECTIVE
  To assess whether the increased prevalence of trisomy 21 in West Berlin in January 1987 might have been causally related to exposure to ionising radiation as a result of the Chernobyl reactor accident or was merely a chance event.
  
  
  METHODS
  Analysis of monthly prevalence of trisomy 21 in West Berlin from January 1980 to December 1989.
  
  
  METHODS
  Confines of West Berlin.
  
  
  RESULTS
  Owing to the former "island" situation of West Berlin and its well organised health services, ascertainment of trisomy 21 was thought to be almost complete. A cluster of 12 cases occurred in January 1987 as compared with two or three expected. After exclusion of factors that might have explained the increase, including maternal age distribution, only exposure to radiation as a result of the Chernobyl reactor accident remained. In six of seven cases that could be studied cytogenetically the extra chromosome was of maternal origin, confirming that nondisjunction had occurred at about the time of conception.
  
  
  CONCLUSIONS
  On the basis of two assumptions--(a) that maternal meiosis is an error prone process susceptible to exogenous factors at the time of conception; (b) that owing to the high prevalence of iodine deficiency in Berlin a large amount of iodine-131 would have been accumulated over a short period--it is concluded that the increased prevalence of trisomy 21 in West Berlin in January 1987 was causally related to a short period of exposure to ionising radiation as a result of the Chernobyl reactor accident.
authors.affiliation: Institut für Humangenetik, Freie Universität Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Sperling
authors.forename: J
authors.initials: J
authors.lastname: Pelz
authors.forename: R D
authors.initials: RD
authors.lastname: Wegner
authors.forename: A
authors.initials: A
authors.lastname: Dörries
authors.forename: A
authors.initials: A
authors.lastname: Grüters
authors.forename: M
authors.initials: M
authors.lastname: Mikkelsen
mesh_terms: D000059:Accidents; D000396:Air Pollutants, Radioactive; D001604:Berlin / Q000453:epidemiology; D004314:Down Syndrome / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D009688:Nuclear Reactors; D015995:Prevalence; D011829:Radiation Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D014455:Ukraine
chemical_list: D000396:Air Pollutants, Radioactive