Analysis of drug release kinetics from degradable polymeric devices.
Drug release kinetics from a degradable polymer undergoing surface erosion have been analysed by mathematical modelling and stimulations. This approach considers drug particles homogeneously dispersed in the matrix, and cases of both a single polymer matrix and a matrix surrounded by a membrane are considered. The influence of different polymer, drug, and membrane parameters on long-term performance has been simulated and provides a theoretical basis for the design of degradable drug delivery devices.
Fischel-Ghodsian
F
F
Department of Engineering Science, University of Oxford, UK.
Newton
J M
JM
D004058:Diffusion; D016503:Drug Delivery Systems; D007700:Kinetics; D008567:Membranes, Artificial; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers; D013499:Surface Properties
D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D011108:Polymers