title: Effect of lignocaine on eicosanoid synthesis by pieces of human gastric mucosa.
abstract: Lignocaine can affect prostaglandin synthesis in various tissues, and it has anti-inflammatory activity. No studies have been made previously on human isolated gut tissues. When concentrations of 5, 50 and 250 micrograms mL-1 lignocaine were incubated with human gastric mucosa/submucosa at 37 degrees C for 30 min, only the highest concentration reduced the levels of prostaglandin E, thromboxane B2 and 6-keto-PGF1 alpha in the incubates, and leukotriene C4/D4 was unaffected. Therapeutically relevant amounts of lignocaine given parenterally would therefore seem unlikely to alter gastric mucosal prostanoids, but high doses can be given orally because of extensive first-pass metabolism in the liver.
authors.affiliation: Department of Surgery, King's College School of Medicine and Dentistry, London, UK.
authors.forename: R K
authors.initials: RK
authors.lastname: Goel
authors.forename: I A
authors.initials: IA
authors.lastname: Tavares
authors.forename: P
authors.initials: P
authors.lastname: Nellgard
authors.forename: A
authors.initials: A
authors.lastname: Jonsson
authors.forename: J
authors.initials: J
authors.lastname: Cassuto
authors.forename: A
authors.initials: A
authors.lastname: Bennett
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis*
chemical_list: D011458:Prostaglandins E; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D008012:Lidocaine