title: Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy.
abstract: We describe a patient with seropositive erosive rheumatoid arthritis (RA) who developed accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate (MTX) therapy while her arthritis remained inactive. MTX is an effective therapy for the articular manifestations of RA. However, on occasion it may result in triggering the development of extraarticular manifestations of RA.
authors.affiliation: University of Toronto Rheumatic Disease Unit, Wellesley Hospital, ON, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Abu-Shakra
authors.forename: P
authors.initials: P
authors.lastname: Nicol
authors.forename: M B
authors.initials: MB
authors.lastname: Urowitz
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002305:Cardiac Tamponade / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D010996:Pleural Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D012218:Rheumatoid Nodule / Q000139:chemically induced* / Q000473:pathology; D014463:Ultrasonography
chemical_list: D008727:Methotrexate