[Relation between cervical conization, microbial colonization and threatening preterm labor].
The relationship between prior cervical conization, the cervical microbial colonization and threatening preterm delivery was investigated in 35 women with preterm premature rupture of the membranes (PPROM), 38 women with idiopathic preterm labor and 75 normal pregnant women at 26-34 weeks of gestation. Prior cervical conization occurred with a significantly higher frequency in PPROM patients than in patients with preterm labor (p < 0.01) and normal pregnant women (p < 0.001). The prevalence of lactobacilli was lower in patients with PPROM than in patients with preterm labor (p < 0.05) and control patients (p = 0.05)--and lower in patients with prior cervical conization than in patients without prior conization (p < 0.05). All other microorganisms occurred with the same frequencies in all groups.


CONCLUSIONS
Prior conization was associated with PPROM. Women with prior conization and women with PPROM had a reduced prevalence of lactobacilli in the cervix. The "absence" of lactobacilli may indicate changes in the cervical microflora, which could be of importance for PPROM.
Svare
J A
JA
Rigshospitalet, føde- og gynaekologisk afdeling Y, København.
Andersen
L F
LF
Langhoff-Roos
J
J
Madsen
H
H
Jensen
E T
ET
Bruun
B G
BG
Lind
I
I
D000328:Adult; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000382:microbiology*; D003718:Denmark / Q000453:epidemiology; D004107:Dilatation and Curettage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D012307:Risk Factors
Relationen mellem cervikal konisation, mikrobiel kolonisation i cervix og truende for tidlig fødsel.