title: A comparison of the three most common Papanicolaou smear collection techniques.
abstract: OBJECTIVE
  To evaluate three common instruments for sampling the endocervical canal: the Q-tip applicator, the Cytobrush, and the Cervex brush.
  
  
  METHODS
  Clinical, cytologic, and histologic data were collected from patients enrolled in the colposcopy clinic at the National Naval Medical Center. Subjects were assigned to one of three techniques: a combination of spatula and swab, a combination of spatula and Cytobrush, and the Cervex brush alone.
  
  
  RESULTS
  There was no significant difference in the ease of use or the amount of patient discomfort among the three methods, although the Cytobrush caused an increase in mild cervical bleeding. The Cytobrush yielded the greatest number of endocervical cells. The swab produced the lowest number of endocervical cells and the greatest cellular distortion. The ability to identify patients with biopsy-proven dysplasia was comparable for each of the three methods.
  
  
  CONCLUSIONS
  The Cytobrush was the best device for sampling the endocervical canal, but it was no more sensitive in detecting cervical dysplasia.
authors.affiliation: Department of Obstetrics and Gynecology, National Naval Medical Center, Bethesda, Maryland.
authors.forename: M
authors.initials: M
authors.lastname: Germain
authors.forename: R
authors.initials: R
authors.lastname: Heaton
authors.forename: D
authors.initials: D
authors.lastname: Erickson
authors.forename: M
authors.initials: M
authors.lastname: Henry
authors.forename: J
authors.initials: J
authors.lastname: Nash
authors.forename: D
authors.initials: D
authors.lastname: O'Connor
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003127:Colposcopy; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*