title: Increased CD10/TdT positive cells in the bone marrow of an infant with immune thrombocytopenia.
abstract: We describe the case of an infant with immune thrombocytopenia whose bone marrow showed an increased percentage of CD10/TdT-positive lymphoid cells that resembled the onset of an acute lymphoproliferative disorder. Genotypic analysis of bone marrow, however, failed to reveal the malignant origin of these B cell precursors. After 8 months of follow-up, the child is alive and well, and shows a chronic form of ITP. Although a relation between this B cell proliferation and the onset of ITP cannot be excluded, it is important to consider this atypical pattern as a benign hematologic condition.
authors.affiliation: Divisione di Ematologia, Ospedale IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
authors.forename: L M
authors.initials: LM
authors.lastname: Melillo
authors.forename: N
authors.initials: N
authors.lastname: Cascavilla
authors.forename: P
authors.initials: P
authors.lastname: Musto
authors.forename: M M
authors.initials: MM
authors.lastname: Minervini
authors.forename: S
authors.initials: S
authors.lastname: Ladogana
authors.forename: A
authors.initials: A
authors.lastname: La Sala
authors.forename: M
authors.initials: M
authors.lastname: Carotenuto
mesh_terms: D001853:Bone Marrow / Q000201:enzymology / Q000276:immunology*; D004253:DNA Nucleotidylexotransferase / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D015260:Neprilysin / Q000032:analysis*; D013921:Thrombocytopenia / Q000201:enzymology / Q000276:immunology*
chemical_list: D004253:DNA Nucleotidylexotransferase; D015260:Neprilysin