Processes of visual recognition in monkeys and their neuronal correlates in the visual cortex: the influence of a blocker of M-cholinoreceptors.
The activity of individual neurons of the visual cortex was recorded simultaneously in behavioral experiments on monkeys before and after the systemic administration of a blocker of M-cholinoreceptors, amizil (0.8-1.0 mg/kg). The animals were trained to delayed visual differentiation of stimuli of various colors. After the administration of amizil, the characteristics of recognition deteriorated substantially: the duration of the storage of information in short-term memory sharply declined, while the time of the motoric reaction increased. The deterioration of these characteristics was accompanied by inhibition of the activity of the neurons of the visual cortex, inhibition which depended on the stage of recognition, and which intensified when there was an increase in the delay interval. The results obtained suggest that cholinergic mechanisms of the visual cortex are included in visual recognition, and apparently play various functional roles at various stages of behavior.
Dudkin
K N
KN
Laboratory of the Regulation of the Functions of Brain Neurons, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences.
Kruchinin
V K
VK
Chueva
I V
IV
D000818:Animals; D001535:Benactyzine / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004192:Discrimination, Psychological / Q000187:drug effects; D008034:Lincomycin / Q000494:pharmacology; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000187:drug effects; D018727:Muscarinic Antagonists; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology*
D018727:Muscarinic Antagonists; D001535:Benactyzine; D008034:Lincomycin