[Analysis of the results obtained in fertilization in vitro according to the degree and type of teratospermia].
The aim of this study was to evaluate the consequences of sperm morphology abnormalities on fertilization capacity. We selected 115 couples who consulted for in vitro fertilization at the Salengro Maternity Ward (Lille, France). Teratospermia was > 40% in all. The mean rate of cleavage was 23% and was significantly lower than in a population which had had in vitro fertilization for a tube indication (63%, p < or = 0.001). In addition, this level was significantly correlated with teratospermia (p < or = 0.05). The ROC method demonstrated that above the threshold of 74% teratospermia, fertilization decreases significantly. We distinguished several types of abnormal morphology and demonstrated a weak correlation between head abnormalities and the rate of cleavage, a stronger correlation between abnormalities of the intermediary piece and rate of cleavage and finally the absence of any correlation between flagella abnormalities and the rate of fertilization. Teratospermia is therefore an important factor in evaluating fertilization capacity. A better selection of normal spermatoids could improve the chance of success in cases of male sterility.
Leroy-Martin
B
B
Laboratoire d'Histologie-Embryologie et Biologie de la Reproduction, Faculté de Médecine, Lille.
Tanguy
B
B
Lorthioir
M
M
Soulez
B
B
Hermand
E
E
D000328:Adult; D002970:Cleavage Stage, Ovum / Q000502:physiology; D005260:Female; D005298:Fertility / Q000502:physiology; D005306:Fertilization / Q000502:physiology; D005307:Fertilization in Vitro; D005544:Forecasting; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000473:pathology; D013076:Sperm Count; D013077:Sperm Head / Q000473:pathology; D013081:Sperm Motility; D013082:Sperm Tail / Q000473:pathology; D013084:Sperm-Ovum Interactions / Q000502:physiology; D013094:Spermatozoa / Q000473:pathology* / Q000502:physiology
Analyse des résultats obtenus en fécondation in vitro selon le degré et le type de tératospermie.