[Bioenergetic mechanisms of the antihypoxic action of mexidol, the succinate-containing derivative of 3-hydroxypyridine].
The mechanism of antihypoxic action of succinate-containing derivative of 3-hydroxypiridine (mexidol) on hypoxic isolated contractive heart was investigated. By means of inhibitory analysis it was shown that the mechanism is connected with oxidation of succinate in mitochondrial respiratory chain. Activation of succinate oxidase pathway in that situation may be regarded as a immediate compensatory mechanism entering in action at limitation of NADH-oxidase pathway and promoting increase of tissue resistance at oxygen deficiency. Thus, mexidol is antihypoxant of energizing action.
Luk'ianova
L D
LD
Atabaeva
R E
RE
Shepeleva
S Iu
SIu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004579:Electron Transport / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D010847:Picolines / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate
Bioénergeticheskie mekhanizmy antigipoksicheskogo deĭstviia suktsinatsoderzhashchego proizvodnogo 3-oksipiridina meksidola.