title: Intravaginal prostaglandin E2 for cervical ripening and initiation of labor. Comparison of a multidose gel and single, controlled-release pessary.
abstract: A study was conducted to compare the efficacy and safety of two methods of delivering prostaglandin E2 (PGE2) as a low-dose gel delivered in up to two sequential, 2.5-mg doses and as a single-dose, controlled-release, 10-mg pessary. A cervical change was present in both groups, but a Bishop score > or = 8 occurred in more nulliparous patients in the pessary than in the gel group by 12 hours after dosing. Labor was initiated without oxytocin more frequently in the pessary than gel group for nulliparas and multiparas. Reversal of uterine hyperstimulation was possible by removal of the pessary without tocolytic therapy. The controlled-release PGE2 pessary was more effective in changing the cervix in nulliparas and in initiating labor and offered the advantage of removal when desired.
authors.affiliation: Department of Obstetrics and Gynecology, University of Nebraska College of Medicine, Omaha 68198-3255.
authors.forename: C V
authors.initials: CV
authors.lastname: Smith
authors.forename: W F
authors.initials: WF
authors.lastname: Rayburn
authors.forename: A M
authors.initials: AM
authors.lastname: Miller
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D002585:Cesarean Section / Q000706:statistics & numerical data; D003692:Delayed-Action Preparations; D015232:Dinoprostone / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010121:Oxytocin / Q000627:therapeutic use; D010298:Parity; D010570:Pessaries; D011247:Pregnancy; D013997:Time Factors; D017211:Treatment Failure; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D010121:Oxytocin; D015232:Dinoprostone