[Effect of perinatal administration of monosodium glutamate (MSG) on the reproductive system of the male rat].
The study was aimed at investigating the effect of monosodium glutamate administered during the perinatal period on the reproductive system of sexually mature male rats. Monosodium glutamate (at a dose of 4 mg/g of body weight) or hypertonic saline was administered subcutaneously to newborn rats at 2--nd, 4-th, 6-th, 8-th and 10-th day of life. At the age of four months the rats were killed and histological and morphometric examinations of testes, epididymis, seminal vesicles and ventral prostate were carried out. Blood serum levels of LH, FSH, testosterone and 17-beta-estradiol were determined by radioimmunoassay. The administration of monosodium glutamate caused inhibition of growth, obesity and decrease in weight of pituitary glands and testes. Blood serum levels of and FSH as well as the height of epithelial cells of accessory sexual glands remained unchanged, whereas testosterone level was lowered.
Miśkowiak
B
B
Katedra i Zakład Histologii i Embriologii AM, Poznaniu.
Limanowski
A
A
Partyka
M
M
D000818:Animals; D000831:Animals, Newborn; D005837:Genitalia, Male / Q000187:drug effects*; D006128:Growth / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000139:chemically induced; D010902:Pituitary Gland / Q000187:drug effects; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D012970:Sodium Glutamate
Wpływ okołourodzeniowego wprowadzania glutaminianu sodu (MSG) na układ reprodukcyjny szczura samca.