title: [Effect of verapamil on arterial pressure and various parameters of heart contractile function in rabbits with prerenal artery hypertension when administered at various times of day].
abstract: The dynamics of arterial blood pressure and some data of cardiac contractility in rabbits with vasorenal hypertension were investigated in 4 seasons of the year. Simultaneously, the effects of verapamil on the said data were studied in rabbits with vasorenal hypertension (verapamil was administered at 12 and 18 h during last 2 weeks of experiment). In different seasons the definite differences in therapeutic effect of verapamil depending on the time of its administration were revealed.
authors.forename: V K
authors.initials: VK
authors.lastname: Lepakhin
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
authors.forename: E S
authors.initials: ES
authors.lastname: Matyev
authors.forename: T A
authors.initials: TA
authors.lastname: Kazanskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Mogilevskiĭ
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004334:Drug Administration Schedule; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D012621:Seasons; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil
vernacular_title: Vliianie verapamila na arterial'noe davlenie i nekotorye pokazateli sokratitel'noĭ funktsii serdtsa u krolikov s renoprivnoĭ arterial'noĭ gipertenzieĭ pri ego vvedenii vraznoe vremia sutok.