[Changes in renal function immediately after the angiography].
The effect of radiographic contrast media upon renal function was investigated in 30 patients with normal renal function using Ioxaglate 320 mgI/ml (0.58 Osm/KgH2O), Iohexol 350 mgI/ml (0.88 Osm/kgH2O) and Iomeprol 400 mgI/ml (0.75 Osm/kgH2O). Before and immediately after conventional abdominal angiography, serum and urinary BUN, creatinine, sodium, osmolality and urinary volume were examined. Urinary minute volume increased remarkably immediately after angiography in all the contrast media groups. In Iohexol 350 and Iomeprol 400, creatinine clearance (Ccr) increased immediately after angiography, while no Ccr increase was observed in Ioxaglate 320. FENa increased immediately after angiography in all the contrast media groups. There were no statistical differences in the changes of FENa among Ioxaglate 320, Iohexol 350 and Iomeprol 400. There was no significant change in CH2O. It becomes evident that the osmotic diuresis and its effect on the proximal tubular function are induced by administrated low osmolar contrast media and that these changes are reversible.
Murakami
R
R
Department of Radiology, Nippon Medical School.
Tajima
H
H
Kumazaki
T
T
D000328:Adult; D000368:Aged; D000792:Angiography; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D007479:Iopamidol / Q000009:adverse effects / Q000031:analogs & derivatives; D007485:Ioxaglic Acid / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
D003287:Contrast Media; C057937:iomeprol; D007472:Iohexol; D007479:Iopamidol; D007485:Ioxaglic Acid