Exercise-induced hyperthermia as a possible mechanism for tendon degeneration.
Mathematical modelling of tendon thermodynamics predicted that the temperature of the central core of the equine superficial digital flexor tendon would plateau at 11 degrees C above the tendon surface temperature during a sustained gallop. A mean temperature differential (between tendon core and surface) of 5.4 (S.E. +/- 1.0) degrees C was demonstrated in vivo in four horses. Peak intra-tendinous temperatures in the range 43-45 degrees C were recorded. Temperatures above 42.5 degrees C are known to result in fibroblast death in vitro [Hall (1988) Radiobiology for the Radiologist, 3rd Edn., pp. 294-329]. These in vivo recordings provide a possible aetiology for the degenerative changes that are observed in the central core of tendons in both equine and human athletes.
Wilson
A M
AM
Department of Anatomy, University of Bristol, U.K.
Goodship
A E
AE
D000125:Achilles Tendon / Q000098:blood supply / Q000503:physiopathology; D000818:Animals; D001831:Body Temperature / Q000502:physiology; D004567:Electrodes, Implanted; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005334:Fever / Q000503:physiopathology*; D005544:Forecasting; D006724:Hoof and Claw; D006736:Horses; D006801:Humans; D008954:Models, Biological; D012039:Regional Blood Flow / Q000502:physiology; D012420:Running / Q000502:physiology; D013710:Tendons / Q000098:blood supply / Q000503:physiopathology*; D013814:Thermal Conductivity; D013816:Thermodynamics; D013821:Thermometers