[Effects of vasoactive cyclooxygenase products on shunt flow and extravascular lung water in acute lung injuries].
Using 50 mongrel dogs with alveolar flooding produced by oleic acid administration, the possible roles of vasoactive cyclooxygenase products on intrapulmonary shunt flow (QS/QT) and extravascular lung water (ETVI) in acutely injured lungs were assessed. Suppressing cyclooxygenase activity with indomethacin administration diminished the concentrations of thromboxane (TX) B2 and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in arterial blood, resulting in a significant reduction in QS/QT. Furthermore, indomethacin completely suppressed the increase in ETVI. Inhibition of TXA2 generation by OKY-046 (thromboxane A2 synthase blocker) diminished the concentration of TXB2 while increasing that of 6-keto-PGF1 alpha in blood. Administration of either OKY-046 or synthetic prostacyclin (PGI2) markedly enhanced QS/QT, in association with an increase in ETVI. In conclusion, the potent vasodilator prostacyclin was considered to enhance shunt flow, leading to the augmentation of edema formation.
Yamaguchi
K
K
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
Mori
M
M
Takasugi
T
T
Oyamada
Y
Y
Kawai
A
A
Asano
K
K
Aoki
T
T
Fujita
H
H
Suzuki
Y
Y
D000208:Acute Disease; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology; D015633:Extravascular Lung Water / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism*; D008689:Methacrylates / Q000494:pharmacology; D009829:Oleic Acids; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism / Q000502:physiology*; D011652:Pulmonary Circulation
D001095:Arachidonic Acids; D008689:Methacrylates; D009829:Oleic Acids; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases; C034364:ozagrel; D007213:Indomethacin