title: Anti-type I collagen antibodies in advanced phases of adjuvant arthritis.
abstract: The aim of this study was to elucidate the existence of autoantibodies directed to type I collagen as a response to connective tissue alterations that occur in inflammatory diseases. We have demonstrated the presence of antibodies to type I collagen during the time course of adjuvant arthritis, by means of the ELISA technique. These autoantibodies reached the highest levels in advanced phases of the arthritic process from 8 to 10 weeks after mycobacteria administration. The hind-paw swelling and the anti-type I collagen antibodies remained for at least 18 weeks post-induction.
authors.affiliation: Experimental Immunopathology Research Group, Faculty of Pharmacy, University of Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Franch
authors.forename: C
authors.initials: C
authors.lastname: Castellote
authors.forename: M
authors.initials: M
authors.lastname: Castell
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis*; D001169:Arthritis, Experimental / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006614:Hindlimb; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000906:Antibodies; D003094:Collagen