title: Detection of anti-desmocollins I and II autoantibodies in two cases of Hallopeau type pemphigus vegetans by immunoblot analysis.
abstract: Pemphigus foliaceus (PF) sera react with a 150 kDa antigen, desmoglein (DG), while pemphigus vulgaris (PV) sera react with a 130 kDa PV antigen. Recent molecular cloning studies have revealed that both DG and PV antigen are members of the cadherin family of cell adhesion molecules and that PV antigen shows very high homology to DG. We have recently noticed that other desmosoal cadherin molecules, desmocollins I and II (DC I/II), are also recognized by some pemphigus antibodies. In the present study we report two cases of Hallopeau type pemphigus vegetans. Immunoblot study revealed that the sera of these cases reacted not only with the PV antigen but also with both DG (PF antigen) and DC I/II. Although the significance of these findings is not known at present, further studies for the antigen profile for more Hallopeau type pemphigus vegetans patients may unravel the pathogenesis of this rare type of pemphigus.
authors.affiliation: Department of Dermatology, Osaka University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Higashiyama
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: D R
authors.initials: DR
authors.lastname: Garrod
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000145:classification / Q000276:immunology* / Q000473:pathology; D015153:Blotting, Western; D002417:Cattle; D051187:Desmocollins; D003896:Desmosomes / Q000276:immunology; D004817:Epidermis / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology*; D010392:Pemphigus / Q000145:classification / Q000276:immunology* / Q000473:pathology; D011994:Recombinant Proteins / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001324:Autoantigens; C081560:DSC1 protein, human; C081561:DSC2 protein, human; D051187:Desmocollins; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins