Characteristics of cervical intraepithelial neoplasia in women infected with the human immunodeficiency virus.
OBJECTIVE
Our purpose was to compare characteristics of cervical intraepithelial neoplasia in relation to human immunodeficiency virus infection among women referred to a public hospital colposcopy clinic with Papanicolaou smears showing cervical intraepithelial neoplasia.


METHODS
An evaluation of cervical intraepithelial neoplasia severity, lesion size, and vulvovaginal lesions with respect to human immunodeficiency virus status was performed.


RESULTS
(1) Human immunodeficiency virus prevalence in 482 women with cytologic characteristics of cervical intraepithelial neoplasia was 13%. (2) In human immunodeficiency virus-infected patients, Papanicolaou smears were less adequate for evaluation and correlated less well with histologic findings than in uninfected patients (p < 0.05). (3) Human immunodeficiency virus-infected patients (n = 47) had more advanced cervical intraepithelial neoplasia, larger cervical lesions, and more associated vulvovaginal lesions than human immunodeficiency virus-negative patients (n = 161). In human immunodeficiency virus-positive women, the severity of cervical intraepithelial neoplasia was not associated with age, whereas in human immunodeficiency virus-negative women, increasing severity was significantly associated with increasing age.


CONCLUSIONS
High rates of human immunodeficiency virus infection in inner-city colposcopy services and high-grade, extensive cervical lesions in infected women warrant special attention.
Fruchter
R G
RG
Department of Obstetrics and Gynecology, State University of New York Health Science Center at Brooklyn 11203.
Maiman
M
M
Sillman
F H
FH
Camilien
L
L
Webber
C A
CA
Kim
D S
DS
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000473:pathology*