title: Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity.
abstract: A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the MIC80, the concentration which inhibits 80% or 12 of the serotypes tested, was determined. Homologation of the alkyl group attached to the oxadiazole ring resulted in a reduction in activity with increased chain length. Introduction of hydrophilic groups in this position rendered the compounds inactive. Increasing the length of the side chain attached to the isoxazole ring resulted in an increase in activity. Replacement of the methyl with alkoxyalkyl substituents retained activity; however, introduction of a hydroxyl group on to the side chain reduced activity. Compound 8a, where both the isoxazole and oxadiazole rings were substituted with methyl groups, was one of the most active compounds in the series. A comparison was made between 8a and the two isomeric oxadiazoles 41 and 46, and an attempt was made to explain the difference in activity by examining electrostatic potential maps and by an energy profiling study. No conclusive results were obtained from these studies.
authors.affiliation: Sterling Winthrop Pharmaceutical Research Division, Collegeville, Pennsylvania 19426-0900.
authors.forename: G D
authors.initials: GD
authors.lastname: Diana
authors.forename: D L
authors.initials: DL
authors.lastname: Volkots
authors.forename: T J
authors.initials: TJ
authors.lastname: Nitz
authors.forename: T R
authors.initials: TR
authors.lastname: Bailey
authors.forename: M A
authors.initials: MA
authors.lastname: Long
authors.forename: N
authors.initials: N
authors.lastname: Vescio
authors.forename: S
authors.initials: S
authors.lastname: Aldous
authors.forename: D C
authors.initials: DC
authors.lastname: Pevear
authors.forename: F J
authors.initials: FJ
authors.lastname: Dutko
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004952:Esters; D006367:HeLa Cells; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000494:pharmacology*; D010069:Oxadiazoles / Q000737:chemistry*; D012229:Rhinovirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004952:Esters; D007555:Isoxazoles; D010069:Oxadiazoles; C045978:disoxaril