[TNF-alpha (cachectin) as a lymphokine regulator].
TNF alpha gen is localised in macrophages, granulocytes, T lymphocytes, astrocytes, NK cells. Virus and bacteria superantigens are main potent inducers of TNF alpha production. TNF alpha activate nuclear transcription factors and is responsible for production of enzymes, regulatory proteins and cytokins. Consequently this cytokine is main regulatory factor in inflammation and immune reactions.
Tchórzewski
H
H
Zakładu Patofizjologii i Immunologii INP WAM. Lodzi.
D000818:Animals; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha
TNF-alpha (kachektyna) jako limfokina regulacyjna.