Fatal group A streptococcal meningitis and toxic shock-like syndrome: case report.
A previously healthy 8-year-old girl presented with flu-like symptoms, developed toxic shock-like syndrome, and died within 48 hours. At autopsy she was found to have purulent meningitis. The group A beta-hemolytic streptococcus isolated from her CSF was a member of clone ET 2. This strain produced a variant form of streptococcal pyrogenic exotoxin A (SPEA 2) that has recently been associated with widespread toxic shock-like syndrome.
Jevon
G P
GP
Department of Pathology, Texas Children's Hospital, Houston.
Dunne
W M
WM
Hawkins
H K
HK
Armstrong
D L
DL
Musser
J M
JM
D001921:Brain / Q000382:microbiology / Q000473:pathology; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000382:microbiology* / Q000473:pathology; D012772:Shock, Septic / Q000134:cerebrospinal fluid / Q000382:microbiology*; D013290:Streptococcal Infections / Q000134:cerebrospinal fluid / Q000473:pathology; D013297:Streptococcus pyogenes