Linkage analysis of X-linked cleft palate and ankyloglossia in Manitoba Mennonite and British Columbia Native kindreds.
A locus (CPX) responsible for X-linked cleft palate and ankyloglossia was previously mapped to the proximal long arm of the X chromosome through DNA marker linkage studies in two large kindred: an Icelandic family and a British Columbia (B.C.) Native family. In this study, additional linkage analyses have been performed in the B.C. family and in a newly identified Manitoba Mennonite family with X-linked cleft palate and ankyloglossia. The Manitoba CPX locus maps to the same region as Icelandic and B.C. CPX. Two-point disease-to-marker linkage analyses in the Manitoba family indicate a maximum lod score (Zmax) between CPX and DXS349 (Zmax = 3.33 at theta = 0.0). In multipoint linkage analysis, combined data from the B.C. and Manitoba families suggest that the most likely location for CPX is at DXS447 in Xq21.1 (multipoint Z = 13.5). The support interval for CPX at DXS447 extends approximately from PGK1 to DXYS1 and includes a newly isolated polymorphic locus DXS1109.
Gorski
S M
SM
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Adams
K J
KJ
Birch
P H
PH
Chodirker
B N
BN
Greenberg
C R
CR
Goodfellow
P J
PJ
D001345:Autoradiography; D001955:British Columbia; D002972:Cleft Palate / Q000208:ethnology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008126:Lod Score; D008297:Male; D008350:Manitoba; D010375:Pedigree; D014059:Tongue / Q000002:abnormalities*; D014960:X Chromosome
D005819:Genetic Markers