[Study of intestinal permeability in celiac disease with 51 Cr-EDTA].
Intestinal permeability was studied in a group of 10 children diagnosed of coeliac disease either when they presented an intestinal villi atrophy while receiving a gluten-containing diet and after, when they had a normal mucosa with the withdrawal of gluten from the diet. Ten healthy children served as controls. The 51 Cr-EDTA (51 Cr-ethylenediaminetetraacetate) was used as probe molecule and it was administered orally. Its urinary excretion showed clear differences between patients with an altered intestinal biopsy and those with a normal histopathology. The excretion of 51 Cr-EDTA remained elevated in celiac patients with a gluten-free diet and normal villi.
Roldán Martín
M B
MB
Unidad de Gastroenterología, Hospital Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá de Henares.
Suárez Cortina
L
L
Perdomo Giraldi
M
M
Camarero Salces
C
C
Escobar Castro
H
H
D000284:Administration, Oral; D001706:Biopsy; D016022:Case-Control Studies; D002446:Celiac Disease / Q000378:metabolism / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004032:Diet; D004492:Edetic Acid / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D005260:Female; D005983:Glutens / Q000008:administration & dosage*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male
D005983:Glutens; D004492:Edetic Acid
Estudio de la permeabilidad intestinal en enfermos celiacos con EDTA-CR51.