title: [Fish oils and rheumatoid arthritis. A randomized and double-blind study].
abstract: The effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with active rheumatoid arthritis was evaluated in a multicentre, randomized and double blind study. Fifty-one patients with active rheumatoid arthritis were included from three Danish hospital Departments of Rheumatology. The patients were allocated to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with a fat composition averaging the Danish diet. Small but significant improvements in morning stiffness, joint tenderness and C-reactive protein were observed. There were no serious side-effects. Dietary supplementation with n-3 PUFA in patients with active rheumatoid arthritis has a modest effect on three out of eight disease variables, without effect on other traditional parameters for monitoring disease activity.
authors.affiliation: Reumatologisk afdeling, Amtssygehuset i Herlev.
authors.forename: K L
authors.initials: KL
authors.lastname: Faarvang
authors.forename: G L
authors.initials: GL
authors.lastname: Nielsen
authors.forename: B S
authors.initials: BS
authors.lastname: Thomsen
authors.forename: K L
authors.initials: KL
authors.lastname: Teglbjaerg
authors.forename: T M
authors.initials: TM
authors.lastname: Hansen
authors.forename: H H
authors.initials: HH
authors.lastname: Lervang
authors.forename: E B
authors.initials: EB
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Dyerberg
authors.forename: E
authors.initials: E
authors.lastname: Ernst
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000178:diet therapy*; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D011379:Prognosis; D013997:Time Factors
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils
vernacular_title: Fiskeolie og reumatoid artrit. En randomiseret og dobbeltblind undersøgelse.