title: Free protein S deficiency in patients with Crohn's disease.
abstract: Multifocal intestinal infarctions, due to thrombosis in small vessels, might be a pathogenetic mechanism for Crohn's disease (CD). Deficiency of free protein S may contribute to the development of such thrombotic occlusions. In the present study free protein S was measured in 54 patients with CD. In 31 patients (57.4%) the plasma concentrations of free protein S were below the lower normal range. The mean value of free protein S in CD patients was 72.2%, as compared with 97.5% in healthy subjects (p < 0.01). The concentrations of C4b-binding protein and protein C were similar in the two groups. Free protein S levels were not correlated to disease activity, previous surgery or complications, extraintestinal manifestations, or current medical therapy. The impairment of the protein S/protein C/thrombomodulin system found in patients with CD favours coagulation and might be of importance for both the development of CD and its thromboembolic complications.
authors.affiliation: Dept. of Medicine, Aker University Hospital, Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Aadland
authors.forename: O R
authors.initials: OR
authors.lastname: Odegaard
authors.forename: A
authors.initials: A
authors.lastname: Røseth
authors.forename: K
authors.initials: K
authors.lastname: Try
mesh_terms: D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000378:metabolism; D003169:Complement Inactivator Proteins; D003424:Crohn Disease / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006023:Glycoproteins; D006801:Humans; D007238:Infarction / Q000150:complications / Q000378:metabolism; D007422:Intestines / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D018455:Protein S Deficiency; D013923:Thromboembolism / Q000150:complications / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins