Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrome.
Anticardiolipin antibodies are produced both in patients with the antiphospholipid syndrome (APS) and in patients with syphilis, but lupus anticoagulant activity has been reported only for the former group. To understand these differences, affinity-purified immunoglobulin G anticardiolipin antibodies from APS (n = 11) and syphilis (n = 5) patients were compared. Only the antibodies from the APS group inhibited prothrombin conversion to thrombin and cross-reacted with phosphatidylserine. These findings may enable better definition of the phospholipid epitopes involved in the hemostatic abnormalities of APS.
Pierangeli
S S
SS
Antiphospholipid Standardization Laboratory, University of Louisville, Kentucky 40292.
Goldsmith
G H
GH
Krnic
S
S
Harris
E N
EN
D017153:Antibodies, Anticardiolipin / Q000502:physiology*; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D010743:Phospholipids / Q000276:immunology; D011516:Prothrombin / Q000378:metabolism; D013587:Syphilis / Q000276:immunology*; D013917:Thrombin / Q000096:biosynthesis
D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G; D010743:Phospholipids; D011516:Prothrombin; D013917:Thrombin