Effective control of cisplatin induced emesis by combination drug regimen.
Thirty two cycles of chemotherapy were administered to sixteen patient containing 50-75 mg/msq. of cisplatin. For antiemetic prophylaxis, each patient received metoclopramide alone in the first cycle and a combination of metoclopramide + dexamethasone + lyrazepam in the next cycle. Effective control of emesis was achieved in 81% cycles on the combination antiemetic regime as compared to 19% on MCP alone. There was no statistical difference in the relief of nausea by the two regimens.
Misra
R
R
Dept. of Obstetrics & Gynaecology, University College of Medical Sciences, Shahadra Delhi, India.
Agarwal
N
N
D000328:Adult; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012074:Remission Induction; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control*
D004338:Drug Combinations; D003907:Dexamethasone; D008787:Metoclopramide; D008140:Lorazepam; D002945:Cisplatin