title: Immunity to polioviruses and tetanus after bone marrow transplantation in children.
abstract: Immunity to tetanus toxoid and polioviruses was studied in 34 (27 allografted, 7 autografted) children who underwent bone marrow transplantation (BMT). At a median time of 3 years after BMT, only one recipient was seronegative for tetanus toxoid. On the contrary 73% of children were seronegative for at least one of the three poliovirus types and 30% for all virus types. Undetectable antibody titers were more frequently found against type 3 than the other two types. We recommend that reimmunizations of children after BMT be based on serologic tests for antibody titers.
authors.affiliation: Clinica Pediatrica dell'Università de Milano, Ospedale San Gerardo, Monza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pezzini
authors.forename: M
authors.initials: M
authors.lastname: Limonta
authors.forename: A
authors.initials: A
authors.lastname: Rovelli
authors.forename: C
authors.initials: C
authors.lastname: Uderzo
authors.forename: A
authors.initials: A
authors.lastname: Locasciulli
authors.forename: O
authors.initials: O
authors.lastname: Maglia
authors.forename: G
authors.initials: G
authors.lastname: Masera
authors.forename: M
authors.initials: M
authors.lastname: Barbi
authors.forename: A
authors.initials: A
authors.lastname: Pozzi
authors.forename: C
authors.initials: C
authors.lastname: Luraschi
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007109:Immunity; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D017955:Poliovirus / Q000276:immunology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D013745:Tetanus Toxoid