Cd2+ and Co2+ at micromolar concentrations stimulate catecholamine secretion by increasing the cytosolic free Ca2+ concentration in cat adrenal chromaffin cells.
Cd2+ and Co2+ at micromolar concentrations increased the cytosolic free Ca2+ concentration, which was measured by fura-2 microfluorometry, in cat adrenal chromaffin cells. Simultaneously, these divalent cations stimulated catecholamine secretion from the perfused adrenal. The present findings suggest that these cations increase the Ca2+ influx by depolarizing the cell membrane and consequently stimulate catecholamine secretion.
Yamagami
K
K
Department of Physiology, Kagoshima University, School of Medicine, Japan.
Nishimura
S
S
Sorimachi
M
M
D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002415:Cats; D003035:Cobalt / Q000494:pharmacology*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005711:Gallopamil / Q000494:pharmacology; D066298:In Vitro Techniques; D008832:Microchemistry; D009538:Nicotine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology
D002395:Catecholamines; D002104:Cadmium; D005711:Gallopamil; D003035:Cobalt; D011189:Potassium Chloride; D009538:Nicotine; D009543:Nifedipine; D002118:Calcium