Effects of chronic manganese toxicity on tissue levels and urinary excretion of nicotinamide nucleotides in rats.
Male rats were exposed to manganese sulphate i.p. daily for a period of four weeks to see its effects on tissue levels and urinary excretion of total nicotinamide nucleotides (TNN). Increased levels of TNN were observed in blood and brain while the levels were found to be decreased in liver. There was a progressive increase in the excretion of TNN during the experimental period. TNN levels in blood and urine might serve as useful biological indicators of Mn toxicity.
Patel
A B
AB
National Institute of Occupational Health (ICMR), Meghani Nagar, Ahmedabad, Gujarat, India.
Pandya
A A
AA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D017895:Manganese Compounds / Q000493:pharmacokinetics; D020149:Manganese Poisoning; D009537:Nicotinamide Mononucleotide / Q000097:blood / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013431:Sulfates / Q000493:pharmacokinetics / Q000633:toxicity*; D014018:Tissue Distribution
D017895:Manganese Compounds; D013431:Sulfates; D009537:Nicotinamide Mononucleotide; C039798:manganese sulfate