title: [Localized or systemic amyloidosis? Value and limitations of Iodine-123 labelled amyloid P component scintigraphy, role of biopsy of minor salivary glands].
abstract: We evaluated the value of serum amyloid P component scintigraphy (123I-SAP) and labial salivary gland biopsy in four patients with apparently localized amyloidosis. One patient had pharyngeal amyloidosis, the second laryngeal amyloidosis, the third retro-ocular amyloidosis and the fourth had carpal tunnel syndrome. Three patients (no 2, no 3, no 4) have abnormal whole body retention of 123I-SAP and positive labial salivary gland biopsy for amyloidosis. Only the first patient had effectively localized amyloidosis and local treatment was sufficient. Melphalan was given to the patients no 2 and no 3, colchicine was given to the patient no 4. Labial salivary gland biopsy and 123I-SAP scintigraphy may give positive argument for the diagnosis of systemic amyloidosis in patients with apparently localized amyloidosis.
authors.affiliation: Service de médecine interne, hôpital Claude-Huriez, CHRU, Lille, France.
authors.forename: E
authors.initials: E
authors.lastname: Hachulla
authors.forename: B
authors.initials: B
authors.lastname: Wechsler
authors.forename: M
authors.initials: M
authors.lastname: Deveaux
authors.forename: P
authors.initials: P
authors.lastname: Godeau
authors.forename: P Y
authors.initials: PY
authors.lastname: Hatron
authors.forename: B
authors.initials: B
authors.lastname: Devulder
authors.forename: A
authors.initials: A
authors.lastname: Janin
authors.forename: X
authors.initials: X
authors.lastname: Marchandise
mesh_terms: D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D012470:Salivary Glands, Minor / Q000473:pathology*; D000683:Serum Amyloid P-Component
chemical_list: D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component
vernacular_title: Amylose localisée ou systémique? Intérêt et limites de la scintigraphie au composant amyloïde P marqué à l'iode 123, place de la biopsie de glandes salivaires accessoires.