title: A case of bullous pemphigoid with antidesmoplakin autoantibodies.
abstract: We present an 84-year-old Japanese male showing typical features of bullous pemphigoid (BP). However, immunofluorescence of normal human skin sections revealed concurrent anti-basement-membrane-zone and anti-keratinocyte-cell-surface autoantibodies in the serum. With immunoblotting, the patient's serum reacted with desmoplakins I and II, as well as with both the 230-kD and the 180-kD BP antigens. The studies for this case may provide us with an insight to understand the occurrence of antidesmoplakin antibodies in paraneoplastic pemphigus.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: A
authors.initials: A
authors.lastname: Ishiko
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins / Q000276:immunology*; D051180:Desmoplakins; D003896:Desmosomes / Q000276:immunology; D000071821:Dystonin; D005455:Fluorescent Antibody Technique; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D008297:Male; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D010391:Pemphigoid, Bullous / Q000276:immunology*; D012867:Skin / Q000276:immunology; D000097805:Collagen Type XVII
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D000071821:Dystonin; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human