[The use of taktivin in experimental apical periodontitis exacerbated by a secondary immunodeficiency state].
Apical periodontitis was simulated in 100 white rats with secondary immunodeficiency induced by a single total x-ray irradiation with the RUM [correction of PYM]-17 device. Nonspecific resistance of the rat body was assessed from the neutrophilic phagocytic activity, serum bactericidal activity, lysozyme and complement levels. These parameters were found reduced in the experimental animals; x-ray examinations revealed changes round the dental root apices. Daily injections of tactivin for 10 days in a dose 2-5 mg/kg b.m. resulted in elevation of the nonspecific resistance parameters, and the x-ray picture in this group of animals was the same as in intact controls; therefore, tactivin normalized the immunity system status and indirectly improved the clinical course of apical periodontitis.
Zyrianov
G V
GV
Dmitrieva
L A
LA
Frolova
T M
TM
Belopol'skiĭ
A A
AA
Babaian
S S
SS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D010455:Peptides / Q000627:therapeutic use*; D010485:Periapical Periodontitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D013949:Thymus Extracts / Q000627:therapeutic use*; D013997:Time Factors; D014916:Whole-Body Irradiation
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Primenenie taktivina pri éksperimental'nom verkhushechnom periodontite, otiagoshchennym vtorichnym immunodefitsitnym sostoianiem.