Effect of policosanol on experimental thrombosis models.
Policosanol is a natural product, obtained from sugar cane wax (Saccharum officinarum L.) with which cholesterol-lowering effects have been demonstrated in experimental models, healthy volunteers and hypercholesterolemic patients. The effects of policosanol on experimental venous and arterial thrombosis in rats were investigated. Policosanol (25 mg/kg) significantly decreased the thrombus weight, in the venous thrombosis models, the protective effect persisting until 4 h after its oral administration. Policosanol (25 mg/kg single dose) was able to reduce rectal temperature variation induced by arterial thrombosis. Also at the same dose policosanol increased 6-keto-PGF1 alpha serum levels in rats.
Carbajal
D
D
Department of Pharmacology Center of Natural Products, CNIC, Playa, Habana, Cuba.
Arruzazabala
M L
ML
Más
R
R
Molina
V
V
Valdés
S
S
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000097:blood; D005233:Fatty Alcohols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
D000924:Anticholesteremic Agents; D005233:Fatty Alcohols; C080710:policosanol; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol