title: Fate of dimethylamine in man.
abstract: 1. The fate of [14C]-dimethylamine was investigated following oral administration to four male volunteers. 2. The major route of excretion was urine, with 94% of the administered radioactivity being voided over 3 days (87% during the first 24 h). Small amounts (1-3%) of radioactivity were found in the faeces and expired air. 3. Metabolism was limited with only 5% being demethylated to methylamine. The remainder of the dose was excreted unchanged. 4. Pharmacokinetic studies indicated rapid (t1/2ab = 8 min) and extensive absorption (bioavailability = 82%) from the gastrointestinal tract followed by widespread distribution and a fairly prompt excretion (t1/2el = 6-7 h) with a plasma clearance of 190 ml/min.
authors.affiliation: Department of Pharmacology and Toxicology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: A Q
authors.initials: AQ
authors.lastname: Zhang
authors.forename: S C
authors.initials: SC
authors.lastname: Mitchell
authors.forename: T
authors.initials: T
authors.lastname: Barrett
authors.forename: R
authors.initials: R
authors.lastname: Ayesh
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D001711:Biotransformation; D002250:Carbon Radioisotopes; D004123:Dimethylamines / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008657:Metabolic Clearance Rate; D011865:Radioisotope Dilution Technique
chemical_list: D002250:Carbon Radioisotopes; D004123:Dimethylamines; C034516:dimethylamine