[The sesquiterpene lactone "azerin" has memory enhancing properties].
The memory property of Sesquiterpene Lactone Azerin, isolated from the plant species Ferula compared with placebo (PCO) and clinical well known drug Nootropyl/Piracetam (NOO) were studied on rats. The experiments showed that Azerin in 7-8 times improved the ability of rats to keep the signs of Passive Avoidance Response (PAR), when NOO only in 3-4 times. The learning and transcorneally amnesic electro-shock leaded to 100% PCO, 63% NOO and only 20% Azerin rats retrograde amnesia syndrome. Thus, the mechanisms of amnestic and antiamnestic properties of Azerin have been studied.
Melikov
E M
EM
Serkerov
S V
SV
Movsumov
G D
GD
Mir-Babaev
N F
NF
D000647:Amnesia / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007783:Lactones / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010889:Piracetam / Q000494:pharmacology; D010919:Placebos; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D007783:Lactones; D010919:Placebos; D012717:Sesquiterpenes; C088612:azerin; D010889:Piracetam
Seskviterpenovyĭ lakton "azerin" obladaet mnesticheskimi svoĭstvami.