Comparison of effects of nicardipine and trichlormethiazide on insulin sensitivity in hypertensive patients.
We performed a randomized, crossover study comparing the effects of nicardipine and trichlormethiazide on insulin sensitivity in 8 untreated essential hypertensive patients. They were treated either with nicardipine or trichlormethiazide for 12 weeks, after which they were treated with the alternative drug for a further 12 weeks. Insulin sensitivity was determined by the hyperinsulinemic euglycemic clamp technique. Nicardipine had no adverse effect on insulin sensitivity. Trichlormethiazide decreased insulin sensitivity index by 12%. As nicardipine does not have an adverse effect on insulin sensitivity, it should be preferred in patients who have a proven metabolic abnormality.
Kageyama
S
S
Department of Internal Medicine (III), Jikei University School of Medicine, Tokyo, Japan.
Yamamoto
J
J
Mimura
A
A
Ishibashi
K
K
Sakurai
T
T
Yokota
K
K
Isogai
Y
Y
Fujita
T
T
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004573:Electrolytes / Q000097:blood; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*; D014237:Trichlormethiazide / Q000627:therapeutic use*
D004573:Electrolytes; D008055:Lipids; D009529:Nicardipine; D014237:Trichlormethiazide