Clinical evaluation of drug efficacy in UTI in men: the significance of bacterial elimination on day one.
With the purpose of assessing whether the effect of a drug at an early stage of administration could serve to predict efficacy at the end of drug treatment, a cephem antibiotic was administered for 5 days (days 0-4) by injection in males with complicated UTI. Results showed that the bacteriological effect on day 1 was reflected in the overall clinical efficacy on day 5. The activity of an antibacterial agent appeared to be reflected in the ability to eliminate bacteria 1 to 2 days after the start of drug administration.
Arakawa
S
S
Dept. of Urology, Kobe University School of Medicine, Hyogo, Japan.
Kamidono
S
S
D000293:Adolescent; D000328:Adult; D002506:Cephalexin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003556:Cystitis / Q000150:complications; D004341:Drug Evaluation; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011704:Pyelonephritis / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
C028352:cefems; D002506:Cephalexin