[The effect of detergents on the immunological activity of the antigens of Neisseria meningitidis serogroup B[].
The complex study of the influence of detergents of different classes and aluminum hydroxide, a traditional adjuvant, on the immunological activity of individual N. meningitidis antigens (outer membrane proteins, polysaccharide B) and the complex preparation containing all these antigens revealed that changes in the antigenic and immunogenic properties of the antigens under study depended on the degree of their purification and the character of modifying substances. Aluminum hydroxide proved to be the most active adjuvant: it stimulated immune response to both outer membrane proteins and antigens of the protein-polysaccharide complex, while decreasing the antigenicity of outer membrane proteins and polysaccharide. Detergents increased the antigenicity of outer membrane proteins, both purified and, to a lesser extent, contained in the complex; still the immune response only to the purified preparation could be stimulated.
Bugaev
L V
LV
Shkurina
E A
EA
Karabak
V I
VI
Alliluev
A P
AP
Petrov
A B
AB
D000536:Aluminum Hydroxide / Q000494:pharmacology; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000187:drug effects* / Q000276:immunology*; D000954:Antigens, Surface / Q000187:drug effects / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000187:drug effects / Q000276:immunology; D003902:Detergents / Q000494:pharmacology*; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D009345:Neisseria meningitidis / Q000145:classification / Q000187:drug effects* / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000187:drug effects / Q000276:immunology; D012703:Serotyping
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D003902:Detergents; D011135:Polysaccharides, Bacterial; D000536:Aluminum Hydroxide
Vliianie detergentov na immunologicheskuiu aktivnost' antigenov Neisseria meningitidis serogruppy B.