Symptomatic brodifacoum ingestion requiring high-dose phytonadione therapy.
We report the deliberate ingestion of a superwarfarin product, brodifacoum, in a 39-y-old male. He presented with prothrombin and partial thromboplastin times of 150 and 113 sec, respectively. His coagulopathy was corrected by administration of blood products and phytonadione. To maintain normal clotting studies this patient required the highest maintenance dose of phytonadione, 200 mg/d, reported to date. The patient was able to tolerate this dose for 5 mo without adverse effects.
Sheen
S R
SR
Poison Control Center, Delaware Valley Regional Poison Control Center, Philadelphia, PA 19104.
Spiller
H A
HA
Grossman
D
D
D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000328:Adult; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D002908:Chronic Disease; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D012378:Rodenticides / Q000506:poisoning*; D013406:Suicide, Attempted; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000627:therapeutic use*
D015110:4-Hydroxycoumarins; D012378:Rodenticides; D010837:Vitamin K 1; C013418:bromfenacoum