[The immunocorrective potentials of an antistaphylococcal immunosorbent in extracting staphylotoxin].
The immunocorrective effect of antistaphylococcal adsorbent prepared on the basis of silochrome, a silica matrix, has been revealed in experiments on peripheral blood lymphocytes obtained from 18 donors. The expression of receptors on human immunoregulating cells has been suppressed by the addition of staphylotoxin at a toxic concentration into the system. The experiments have shown that immunosorption is capable of extracting the toxin from the solution to a considerable degree, thus preventing the suppression of the receptor apparatus of immunoregulating lymphocytes. Staphylotoxin has been found capable of forming complexes with plasma ingredients, which increases the adsorption capacity of the immunosorbent.
Bol'shakov
I N
IN
Kulaev
D V
DV
Silant'eva
O V
OV
Kulak
V G
VG
Lopukhin
Iu M
IuM
D000276:Adjuvants, Immunologic; D000327:Adsorption; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D001427:Bacterial Toxins / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007163:Immunosorbent Techniques; D007164:Immunosorbents; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007202:Indicators and Reagents; D011971:Receptors, Immunologic / Q000187:drug effects / Q000276:immunology; D058428:Silica Gel; D012822:Silicon Dioxide; D012996:Solutions; D013211:Staphylococcus aureus / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D007164:Immunosorbents; D007166:Immunosuppressive Agents; D007202:Indicators and Reagents; D011971:Receptors, Immunologic; D012996:Solutions; C036117:staphylotoxin; D058428:Silica Gel; D012822:Silicon Dioxide
Immunokorrigiruiushchie vozmozhnosti protivostafilokokkovogo immunosorbenta pri izvlechenii stafilotoksina.