title: Acute necrotizing pancreatitis: a multicenter study.
abstract: A multicenter study of acute necrotizing pancreatitis (ANP) classified in accordance with the Balthazar criteria (grades D and E), has been performed in 12 teaching hospitals. A total of 233 patients were reviewed, and the mortality rate was 26.6%. The most common etiology was biliary pancreatitis (45.5%). Among the complications, shock, renal insufficiency, pulmonary insufficiency and hemorrhagic gastritis were associated with a mortality rate of 51-66%. Diffuse fluid collections were associated with a higher mortality rate (26.8%) than localized fluid collections (14.5%). In 106 patients with gallstone pancreatitis, early surgery was performed in 17, and 5 patients (29.4%) died. No mortality was observed in 32 patients with delayed surgery. Sphincterotomy was performed in 13 patients, and 4 (30.7%) died. Early surgery (necrosectomy and closed peritoneal lavage) was undertaken in 75 patients, with a mortality rate of 39%. In conclusion, the morbidity and mortality rates of ANP can be improved with proper monitoring, adequate supportive care and the judicious use of surgery based on clinical and morphological findings.
authors.affiliation: Department of Surgery, Hospital Clinic de Barcelona, University of Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Fernández-Cruz
authors.forename: S
authors.initials: S
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Valderrama
authors.forename: A
authors.initials: A
authors.lastname: Sáenz
authors.forename: L
authors.initials: L
authors.lastname: Guarner
authors.forename: L
authors.initials: L
authors.lastname: Aparisi
authors.forename: A
authors.initials: A
authors.lastname: Espi
authors.forename: E
authors.initials: E
authors.lastname: Jaurietta
authors.forename: L
authors.initials: L
authors.lastname: Marruecos
authors.forename: J
authors.initials: J
authors.lastname: Gener
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010195:Pancreatitis / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016016:Proportional Hazards Models; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology