title: A case of malignant hemangiopericytoma: an immunohistochemical and ultrastructural study.
abstract: We report one case of malignant hemangiopericytoma which started with a tumor in the lower jaw and multiple nodules in the lung. The tumor quickly metastasized to the brain and chemotherapy was not at all effective. Hemangiopericytoma is generally diagnosed by its histological characteristics. Recently, however, electron microscopy and immunohistochemical methods have been used for its diagnosis. In our case, electron micrograph showed the growth of hemangiopericytoma cells around immature endothelial cells. In addition, the tumor cells reacted positively only with anti-vimentin antibodies, and the endothelial cells in the tumor tissue were positive for antifactor VIII antibodies. The observed features were consistent with the characteristics of hemangiopericytoma.
authors.affiliation: Third Department of Internal Medicine, Oita Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sugisaki
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: E
authors.initials: E
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Mizuki
mesh_terms: D000911:Antibodies, Monoclonal; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000648:ultrastructure; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006393:Hemangiopericytoma / Q000175:diagnosis* / Q000556:secondary* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D013365:Submandibular Gland Neoplasms / Q000473:pathology; D014746:Vimentin / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D014746:Vimentin; D005169:Factor VIII