Bone marrow granulomas, fever, pancytopenia, and lupus-like syndrome due to tocainide.
We describe the case of a patient in whom a syndrome of fever, pancytopenia, pleural effusion, hepatosplenomegaly, positive ANA antibodies, and bone marrow granulomas developed in association with tocainide therapy. Tocainide, a recognized, albeit rare, cause of fever, lupus-like syndrome, and cytopenias, should be added to the list of medications that can cause bone marrow granulomas.
Gelfand
M S
MS
Department of Medical Education, Methodist Hospitals of Memphis, TN.
Yunus
F
F
White
F L
FL
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D005334:Fever / Q000139:chemically induced*; D005500:Follow-Up Studies; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced*; D016677:Tocainide / Q000009:adverse effects*
D000974:Antibodies, Antinuclear; D016677:Tocainide