Effects of magnesium, high energy phosphates, piracetam and thiamin on erythrocyte transketolase.
Erythrocyte transketolase activity coefficient (ETK-AC) and affinity for coenzyme (Km TPP) were assessed in 50 patients with transketolase abnormalities such as fibromyalgia or senile dementia of Alzheimer's type, before and after magnesium (Mg), thiamin+pyridoxine (B1,B6), high energy phosphates (HEP) (phosphocreatinine of adenosine triphosphate), and piracetam. Compared to 12 untreated patients, ETK-AC was significantly decreased with B1,B6 (P < 0.05, n = 10); Km-TPP was significantly decreased with HEP (P < 0.05, n = 20) and piracetam (P < 0.01, n = 5). In nine other patients treated with HEP + B1,B6 + magnesium, ETK-AC and Km TPP were both significantly decreased.
Eisinger
J
J
Department of Rheumatology, C.H.I. Toulon, La Seyne/mer, France.
Bagneres
D
D
Arroyo
P
P
Plantamura
A
A
Ayavou
T
T
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D012189:Retrospective Studies; D013831:Thiamine / Q000494:pharmacology*; D014174:Transketolase / Q000097:blood* / Q000187:drug effects
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D014174:Transketolase; D008274:Magnesium; D013831:Thiamine; D010889:Piracetam