title: From growth cone to synapse: the life history of the RP3 motor neuron.
abstract: In Drosophila, the ability to analyze the development of individually identified neurons with a variety of imaging and biophysical techniques can be complemented by sophisticated genetics and molecular biology. This powerful combination is allowing the development and function of single neurons and their synaptic connections to be unraveled at an unparalleled level of resolution. In this article, we focus on a single, identified motoneuron--RP3--arguably the best understood neuron in the fruitfly. Many events in the life history of RP3 are well characterized, including cell migration, axon outgrowth and pathfinding within the central nervous system, pathfinding in the periphery to its appropriate muscle target domain, the specific recognition of its muscle targets, the events of synapse formation and maturation, and its mature function in the locomotion of the fly larva. Genetic analysis has revealed mutations in a number of different genes which affect specific aspects of RP3 development from axon outgrowth to synapse formation.
authors.affiliation: Department of Zoology, University of Cambridge, UK.
authors.forename: K
authors.initials: K
authors.lastname: Broadie
authors.forename: H
authors.initials: H
authors.lastname: Sink
authors.forename: D
authors.initials: D
authors.lastname: Van Vactor
authors.forename: D
authors.initials: D
authors.lastname: Fambrough
authors.forename: P M
authors.initials: PM
authors.lastname: Whitington
authors.forename: M
authors.initials: M
authors.lastname: Bate
authors.forename: C S
authors.initials: CS
authors.lastname: Goodman
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D004330:Drosophila / Q000196:embryology*; D009046:Motor Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*