[Differences in the action of serotonin 1A-receptor agonists on rotating behavior or rats with unilaterally raphe-lesioned rats].
The differences between buspirone and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced turning behaviour has been investigated in rats with unilateral lesions of the dorsal and/or medial raphe nuclei (DR, MR). 5-MeODMT caused a most intensive contralateral turning in rats with MR lesions and least intensive ones in rats with both MR and DR lesions. Effect of buspirone depended on specific raphe nuclei lesions. Rats with unilateral lesions of both raphe nuclei caused a high locomotor activity in stress situation--free run wheels, the lowest ones--rats with DR lesions.
Bondarenko
N A
NA
Bondarenko
N A
NA
Voronina
T A
TA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002065:Buspirone / Q000494:pharmacology*; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000293:injuries; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D008732:Methoxydimethyltryptamines; D017366:Serotonin Receptor Agonists; D002065:Buspirone
Razlichiia v deĭstvii agonistov serotoninovykh 1A-retseptorov na rotatsionnoe povedenie drys s unilateral'no razrushennymi iadrami shva.