[Assessment of myocardial metabolic reserve with positron emission tomography and C-11 acetate].
Positron emission tomography (PET) with C-11 acetate allows noninvasive quantification of myocardial oxidative metabolism. To assess the myocardial metabolic reserve, clearance of C-11 acetate from the myocardium was measured with PET in 8 normal subjects at rest and during the infusion of dobutamine (inotropic agent) or dipyridamole (vasodilator). During dobutamine infusion, the clearance rate constant of C-11 acetate increased significantly (0.063 +/- 0.014 vs 0.109 +/- 0.016, p < 0.002) in good correlation with the rate-pressure product (r = 0.83). During dipyridamole infusion, myocardial acetate clearance also significantly increased (0.088 +/- 0.024, p < 0.05) in correlation with the rate-pressure product (r = 0.54). In normal myocardium, myocardial oxidative metabolism increased in response to increased work load with pharmacological stress. These findings suggest that PET with C-11 acetate and pharmacological stress may be a promising approach for the evaluation of metabolic reserve in patients with ischemic heart disease.
Ono
S
S
Department of Internal Medicine, Kyoto University Faculty of Medicine.
Nohara
R
R
Kambara
H
H
Okuda
K
K
Mohiuddin
I H
IH
Tamaki
N
N
Konishi
J
J
D000085:Acetates; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002250:Carbon Radioisotopes; D004176:Dipyridamole; D004280:Dobutamine; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D000085:Acetates; D002250:Carbon Radioisotopes; D004280:Dobutamine; D004176:Dipyridamole