Post-radiation gliomas.
OBJECTIVE
Radiotherapy is important in the treatment of neoplasm of the central nervous system, but various side effects, particularly neoplastic, have been described. Recently, post-radiation gliomas have been reported.


METHODS
The authors review 88 cases of cerebral glioma following radiotherapy in patients operated for neoplasms of the nervous system, including 6 personal cases of post-radiation gliomas treated in the Neurosurgical Division of the Department of Neurological Sciences, "La Sapienza" University, Rome. The criteria used to define this unusual pathologic association are discussed.


RESULTS
There was a male predominance. Post-radiation gliomas were particularly malignant, the average dose was 33 Gy, and average free latency was 9.6 years. The first disease was most frequently acute lymphatic leukemia.


CONCLUSIONS
Post-radiation gliomas have particular features but do not present a histologic or clinical behavior different from analogous spontaneous gliomas. The fact that 88 cases have been reported in recent years suggests that a thorough biological, clinical studies be carried out on this association.
Salvati
M
M
Department of Neurological Sciences, Neurosurgery, La Sapienza University of Rome, Italy.
Puzzilli
F
F
Bristot
R
R
Cervoni
L
L
D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology*; D005260:Female; D005910:Glioma / Q000209:etiology*; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*