title: Effects of disposable or interchangeable positive end-expiratory pressure valves on work of breathing during the application of continuous positive airway pressure.
abstract: OBJECTIVE
  To determine which of a series of disposable or interchangeable positive end-expiratory pressure (PEEP) devices functions with the least imposition of inspiratory and expiratory work during continuous positive airway pressure.
  
  
  METHODS
  Prospective laboratory evaluation performed on a lung model.
  
  
  METHODS
  Research laboratory at a university medical center.
  
  
  METHODS
  A spontaneously breathing lung model, created from a training test lung and a volume ventilator, were used to simulate a patient spontaneously breathing at a tidal volume of 0.4 L, peak inspiratory flow of 40 L/min, an inspiration/expiration ratio of 1:2, and a respiratory rate of 20 breaths/min. Ten PEEP valves attached to a continuous high-flow system were evaluated.
  
  
  RESULTS
  All of the PEEP valves studied imposed high levels of both inspiratory and expiratory work of breathing. The BE-171 and BE-142 valves (Instrumentation Industries) imposed the least amount of inspiratory work. In general, imposed inspiratory work accounted for approximately 70% to 80% of total imposed work of breathing.
  
  
  CONCLUSIONS
  All of the disposable/interchangeable PEEP valves that were studied imposed a considerable amount of both inspiratory and expiratory work, even when the continuous flow provided exceeded the peak inspiratory flow demands of the lung model. The primary reason for the high imposed work levels is the high gas-flow resistance of all of the valves studied.
authors.affiliation: Department of Anesthesiology, Massachusetts General Hospital, Boston 92114.
authors.forename: R M
authors.initials: RM
authors.lastname: Kacmarek
authors.forename: H
authors.initials: H
authors.lastname: Mang
authors.forename: N
authors.initials: N
authors.lastname: Barker
authors.forename: M C
authors.initials: MC
authors.lastname: Cycyk-Chapman
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D004209:Disposable Equipment / Q000145:classification / Q000592:standards*; D004867:Equipment Design; D006801:Humans; D008422:Materials Testing; D008954:Models, Biological; D010366:Peak Expiratory Flow Rate / Q000502:physiology; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D011446:Prospective Studies; D013990:Tidal Volume / Q000502:physiology; D014939:Work of Breathing / Q000502:physiology*