[An amplitude-interval analysis of the electrocorticogram of the normal rat and under the action of fenamine and buspirone].
The ECoG effects of natural vigilance changes were analysed on a microcomputer in rats. In addition, the effects of the psychostimulant phenamine (1 mg/kg, i.p.) and the anxiolytic buspirone (1.5 mg/kg, i.p.) were studied. The ECoG data were processed using the amplitude-interval analysis technique. The two drugs significantly modified ECoG: the maximum effect was observed within the first 30 min after buspirone administration and at 30-60 min after phenamine. Each drug affected the ECoG in its own particular manner, which was similar to their natural activation, but not identical to it. The findings provide evidence for the assumption that the activation processes play an important role in making buspirone show its psychotropic effects.
Diadenko
A I
AI
Voronina
T A
TA
Andronati
S A
SA
D000465:Algorithms; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects* / Q000295:instrumentation; D051381:Rats; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology
D000661:Amphetamine; D002065:Buspirone
Amplitudno-interval'nyĭ analiz élektrokortikogrammy krysy v norme i pri deĭstvii fenamina i buspirona.