Regulation of gonadotropin receptor gene expression.
The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alternative splicing in gonadotropin receptor function.
Themmen
A P
AP
Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Netherlands.
Kraaij
R
R
Grootegoed
J A
JA
D000818:Animals; D003001:Cloning, Molecular; D000242:Cyclic AMP / Q000502:physiology; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D006066:Gonads / Q000378:metabolism; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D008297:Male; D016366:Open Reading Frames; D009928:Organ Specificity; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011967:Receptors, Gonadotropin / Q000096:biosynthesis / Q000145:classification / Q000235:genetics* / Q000502:physiology; D012756:Sheep; D013552:Swine
D012739:Gonadal Steroid Hormones; D006133:Growth Substances; D012333:RNA, Messenger; D011967:Receptors, Gonadotropin; D000242:Cyclic AMP; D019204:GTP-Binding Proteins