Decreased dopamine transporters with age in health human subjects.
The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21-63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age-related decline in dopamine transporters in healthy individuals.
Volkow
N D
ND
Medical Department, Brookhaven National Laboratory, Upton, NY 11973.
Fowler
J S
JS
Wang
G J
GJ
Logan
J
J
Schlyer
D
D
MacGregor
R
R
Hitzemann
R
R
Wolf
A P
AP
D000328:Adult; D000375:Aging / Q000378:metabolism*; D001479:Basal Ganglia / Q000378:metabolism; D001692:Biological Transport; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002352:Carrier Proteins; D002531:Cerebellum / Q000378:metabolism; D003042:Cocaine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D011877:Radionuclide Imaging
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D003042:Cocaine; D004298:Dopamine