title: Tec homology (TH) adjacent to the PH domain.
abstract: The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Ras GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.
authors.affiliation: Center for Structural Biochemistry, Karolinska Institute, NOVUM, Huddinge, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Vihinen
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: C I
authors.initials: CI
authors.lastname: Smith
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D000595:Amino Acid Sequence; D001798:Blood Proteins / Q000737:chemistry; D016384:Consensus Sequence; D008969:Molecular Sequence Data; D005810:Multigene Family; D010750:Phosphoproteins; D011505:Protein-Tyrosine Kinases / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D001798:Blood Proteins; D010750:Phosphoproteins; C039077:platelet protein P47; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human