Dietary fatty acids and breast cancer invasion and metastasis.
This review presents the evidence for the hypothesis that dietary linoleic acid and its metabolic derivative arachidonic acid enhance the metastatic process in breast cancer. Key biochemical events are eicosanoid biosynthesis and protein kinase C activation, both of which are involved in tumor cell invasion and angiogenesis. It is concluded that the utilization of appropriate dietary interventions and pharmacological inhibitors offers a promising approach to suppress metastasis.
Rose
D P
DP
Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, NY 10595.
Hatala
M A
MA
D016718:Arachidonic Acid / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D004041:Dietary Fats / Q000009:adverse effects*; D015777:Eicosanoids / Q000378:metabolism; D004789:Enzyme Activation; D005227:Fatty Acids / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000517:prevention & control; D011493:Protein Kinase C / Q000378:metabolism
D004041:Dietary Fats; D015777:Eicosanoids; D005227:Fatty Acids; D016718:Arachidonic Acid; D011493:Protein Kinase C