title: [Progressive multifocal leukoencephalopathy and AIDS. Response to cytarabine].
abstract: PML affects 4% of patients with AIDS and there is no effective treatment. Five cases of PML-AIDS have been described, showing clinical and radiological improvement after treatment with C-ara. We describe the case of a 33-year-old woman, addict to heroin, her clinical record including VIH infection, pneumonia by P. carinii, milliary tuberculosis, infection by virus B and C and treatment with AZT and tuberculostatics since January, 1992. In May, she began to develop a cerebellar syndrome. Images obtained with nuclear magnetic resonance were typical of PML. Subsequently, treatment with C-ara (2 mg/kg/day IV during 5 days each 4-6 weeks) was begun. From the third month of treatment on, the patient showed a clinical improvement and as of the sixth month, the affected areas of white substance were reduced in size. In addition, CD4 improved. Although in this patient a positive effect was observed after treatment with C-area, it should be verified in a controlled clinical trial.
authors.affiliation: Servicio de Medicina Interna, Hospital Virgen de la Luz., Cuenca.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hervas Laguna
authors.forename: J A
authors.initials: JA
authors.lastname: Nieto Rodríguez
authors.forename: M P
authors.initials: MP
authors.lastname: Geijo Martínez
authors.forename: M D
authors.initials: MD
authors.lastname: Ruiz Ribo
authors.forename: S
authors.initials: S
authors.lastname: Borregón
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D003561:Cytarabine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy*
chemical_list: D003561:Cytarabine
vernacular_title: Leucoencefalopatía multifocal progresiva y SIDA. Respuesta a la citarabina.