title: Molecular epidemiology of recent United Kingdom isolates of Neisseria meningitidis serogroup C.
abstract: The genomes of 34 recent United Kingdom isolates of Neisseria meningitidis serogroup C were examined by restriction enzyme digestion and by conventional and pulsed-field gel electrophoresis (PFGE). Strains were assigned to groups on the basis of the Dice similarity coefficient; strains with values of > 92% were considered to be clonally related. Twelve clones were identified by PFGE. Strains of two clonal groups predominated. Restriction endonuclease analyses using the 'high frequency cleavage' endonuclease Stu I and conventional electrophoresis gave 11 groups; in general it had lower resolving power than PFGE.
authors.affiliation: Department of Medical Microbiology, University of Aberdeen Medical School, Foresterhill.
authors.forename: D E
authors.initials: DE
authors.lastname: Yakubu
authors.forename: F J
authors.initials: FJ
authors.lastname: Abadi
authors.forename: T H
authors.initials: TH
authors.lastname: Pennington
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006801:Humans; D007621:Karyotyping; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics; D015183:Restriction Mapping; D012703:Serotyping; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D004269:DNA, Bacterial