title: Relative effects of left ventricular mass and conduction disturbance on activation in patients with pathological left ventricular hypertrophy.
abstract: OBJECTIVE
  To investigate the relative effects of left ventricular mass and conduction disturbance on the duration and axis of the QRS complex in patients with left ventricular hypertrophy and a normal cavity size.
  
  
  METHODS
  Retrospective and prospective study of 42 patients with pathological left ventricular hypertrophy and 17 normal controls by electrocardiography, echocardiography, and pulsed Doppler recordings.
  
  
  METHODS
  Tertiary cardiac referral centre.
  
  
  METHODS
  42 patients (mean (SD) age 58(16)) with left ventricular hypertrophy and normal cavity size. 17 had stenotic or replaced aortic valves, 14 had hypertension, 9 had hypertrophic cardiomyopathy and 2 had left ventricular hypertrophy without obvious cause. 17 normal people (mean (SD) age 47(20)) were used as controls.
  
  
  RESULTS
  The values of QRS duration segregated into two normally distributed populations, with a cut off point at 135 ms. When patients with QRS duration of < 135 ms (n = 30) were compared with those with QRS duration of > or = 135 ms (n = 12), there were no significant differences in age, heart rate, left ventricular size, shortening fraction, left ventricular mass and total QRS amplitude. Both the PR and QT intervals were, however, longer in patients with a QRS duration of > or = 135 ms, and the extent of incoordinate left ventricular wall motion during the preejection period was greater. When it was < 135 ms the QRS duration was strikingly correlated with left ventricular mass (r = 0.81, p < 0.01). The onsets of transverse septal motion and of posterior wall thickening were normal, as were the onsets of the longitudinal motion of left, septal, and right atrioventricular junctions. When the QRS duration was > or = 135 ms the onset of transverse septal motion and of the longitudinal right atrioventricular junction were both normal, but that of the posterior wall thickening (p < 0.01) and the longitudinal motion of the septum (p < 0.05) and lateral left ventricular wall (p < 0.01) were significantly delayed. Peak rates of left ventricular dimension decrease (p < 0.01) and increase (p < 0.01) were both reduced, as were the peak rates of the long axis shortening of the septum (p < 0.01) and left atrioventricular junction (p < 0.05), whereas the peak rates of posterior wall thickening and thinning did not differ between the two groups. Mean isovolumic relaxation time was longer (p < 0.05) in patients with QRS duration of > or = 135 ms and the peak velocity of the A wave and thus the A to E ratio was greater than in patients with a QRS duration of < 135 ms and that of the E wave was similar in the two groups.
  
  
  CONCLUSIONS
  In patients with left ventricular hypertrophy the values of QRS duration are bimodally distributed, with a cut off point at 135 ms. When QRS duration is < 135 ms, left ventricular mass seems to be closely related to QRS duration, making it the dominant factor determining the activation time. Once QRS duration reaches > or = 135 ms the correlation with mass no longer exists. The statistical distribution, electrocardiographic characteristics, and incoordination pattern of left ventricular wall motion all suggest the development of a proximal left bundle branch block.
authors.affiliation: Cardiac Department, Royal Brompton National Heart and Lung Hospital, London.
authors.forename: H B
authors.initials: HB
authors.lastname: Xiao
authors.forename: S J
authors.initials: SJ
authors.lastname: Brecker
authors.forename: D G
authors.initials: DG
authors.lastname: Gibson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004452:Echocardiography / Q000379:methods; D015150:Echocardiography, Doppler / Q000379:methods; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies