Cytogenetic studies in five patients with Sézary syndrome.
A cytogenetic study was performed in five patients with Sézary syndrome. Metaphases were obtained from a phytohemagglutinin-stimulated lymphocyte culture. The five patients showed abnormal karyotypes. The chromosomes preferentially involved in numerical aberrations were chromosomes 10 (monosomy) and 13 (monosomy); involved in structural changes were chromosomes 1, 2, 4, 6, and 14. In our series, all patients showed progression of the disease.
Solé
F
F
Laboratori de Citologia Hematològica, Hospital Central L'Aliança, Barcelona, Spain.
Woessner
S
S
Vallespi
T
T
Pérez Losada
A
A
Florensa
L
L
Irriguible
D
D
Vila
J
J
Sans-Sabrafen
J
J
D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012751:Sezary Syndrome / Q000235:genetics*