Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.
Ghosh
A K
AK
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.
Thompson
W J
WJ
Fitzgerald
P M
PM
Culberson
J C
JC
Axel
M G
MG
McKee
S P
SP
Huff
J R
JR
Anderson
P S
PS
D018360:Crystallography, X-Ray; D015195:Drug Design; D005663:Furans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D006860:Hydrogen Bonding; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism; D019258:Saquinavir
D005663:Furans; D017320:HIV Protease Inhibitors; D007546:Isoquinolines; D011804:Quinolines; C088801:L 739594; C018674:tetrahydrofuran; D016333:HIV Protease; D019258:Saquinavir