Influence of RF capacitive heating on the alpha 1-adrenergic receptors of rat prostates.
The aim of this study was to find out the influence of radiofrequency (RF) capacitive heating on the alpha 1-adrenergic receptor of rat prostates. The prostates of 30-week-old Wistar rats were submitted to a 1-hour single session of RF capacitive heating at 45 degrees C. The ventral prostates that were submitted to heating were compared to those of other rats that were not submitted to heating. In order to determine the density of alpha 1-adrenergic receptors in rat ventral prostates, binding assays for alpha 1-adrenergic receptor were performed with [3H]prazosin in membrane preparations. The receptor density in the control group was 27.07 +/- 3.75 fmol/mg protein. The alpha 1-adrenergic receptor density (Bmax) in the thermotherapy group was 17.91 +/- 5.15 fmol/mg protein. A remarkable decrease in the density of alpha 1-adrenergic receptors was observed in the rat prostates of the thermotherapy group. In conclusion, the present results demonstrate that heating the rat prostate by RF capacitive heating damages the alpha 1-adrenergic receptors.
Kawamura
K
K
Department of Urology, Kanazawa Medical University, Ishikawa, Japan.
Suzuki
K
K
Tsugawa
R
R
Taniguchi
N
N
Matsunou
H
H
D000818:Animals; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D008297:Male; D008872:Microwaves; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*
D018340:Receptors, Adrenergic, alpha-1