Prenatal diagnosis of twin zygosity by DNA 'fingerprint' analysis.
A twin pregnancy with one hydrocephalic fetus with oligohydramnios is presented. Sonographic evaluation could not exclude monochorionicity. Before considering selective feticide, blood samples from both fetuses were examined for DNA 'fingerprint' analysis. The different banding patterns of the blood samples established dizygosity. This procedure is suggested in cases where sonography fails to determine chorionicity.
Appelman
Z
Z
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Manor
M
M
Magal
N
N
Caspi
B
B
Shohat
M
M
Blickstein
I
I
D000032:Abortion, Therapeutic; D000328:Adult; D016172:DNA Fingerprinting; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014430:Twins, Monozygotic / Q000235:genetics*