Pharmacological properties of the extract of thymus gland (Thymomodulin-TFX) and its effect on reproduction.
The effect of Thymomodulin-TFX on pentetrazole convulsions, tremorine-induced tremor, pain response to intraperitoneal acetic acid injection, hexobarbital sleeping time, isolated guinea pig ileum, isolated rat uterus, rabbit skeletal muscle response, diuresis and corneal response was tested. In addition the effect of TFX on reproduction of albino rats was investigated. In doses up to 20 mg/kg, 8 times higher than clinical doses, TFX did not reveal any unwanted effects. The results of tests widen the security margin for TFX's usage.
Kosmala
M
M
Department of Pharmacology, Pharmaceutical Research Institute, Warsaw, Poland.
Oledzka
K
K
Kaszczyńska
M
M
Lewandowski
K
K
Przemyk
B
B
Filczewski
M
M
Sliwoska
M
M
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013949:Thymus Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014590:Uterine Contraction / Q000187:drug effects
C019108:TFX; D013949:Thymus Extracts; C051006:thymomodulin