Evaluation of the nucleolar organizer region associated proteins in oral squamous cell carcinoma.
Silver-binding nucleolar-organizer regions (AgNORs) were counted in sections from formalin-fixed, paraffin embedded blocks of oral squamous cell carcinoma. Twenty-four cases were histologically classified as grade 1 and fourteen cases as grade 2. In counting AgNORs two specifications were used. The mean number of AgNORs/nucleus (mAgNORs) was used as indicator of the DNA content and the percentage of tumor cells containing five or more AgNORs/nucleus (pAg-NORs) as indicator of the proliferative activity. These counts were examined with respect to their relation to the histologic grading. The pooled mean counts were: Grade 1 carcinomas mAgNORs 4.73 +/- 1.04 and pAgNORs 49.87 +/- 23.41 (mean +/- SD); Grade 2 carcinomas mAgNORs 7.04 +/- 0.95 and pAgNORs 79.14 +/- 20.14. The differences of these results between grade 1 and 2 were statistically significant. These data possibly indicate that in grade 2 oral squamous cell carcinoma there is a higher DNA content and proliferative activity of the tumor cells than in grade 1.
Epivatianos
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Department of Oral Medicine and Oral Pathology, Dental School of Aristotle University, Thessaloniki, Greece.
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D009687:Nuclear Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis
D009363:Neoplasm Proteins; D009687:Nuclear Proteins