title: Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice.
abstract: To elucidate the role of mitochondrial oxidative phosphorylation in neuronal aging, we have studied the activity of the respiratory complexes in the brain of young, adult and old mice. In synaptic mitochondria, we found a significant decrease in complexes IV (29%, P < 0.001) and V (21%, P < 0.01) in old as compared with adult mice. Nonsynaptic mitochondria also showed a senescent decrease in complexes I (15%, P < 0.01), II + III (34%, P < 0.01) and IV (17%, P < 0.01) activities. These findings suggest a dysfunction in mitochondrial oxidative phosphorylation in brain aging.
authors.affiliation: Instituto de Neurociencias, Facultad de Medicina, Universidad de Alicante, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Ferrándiz
authors.forename: M
authors.initials: M
authors.lastname: Martínez
authors.forename: E
authors.initials: E
authors.lastname: De Juan
authors.forename: A
authors.initials: A
authors.lastname: Díez
authors.forename: G
authors.initials: G
authors.lastname: Bustos
authors.forename: J
authors.initials: J
authors.lastname: Miquel
mesh_terms: D000332:Aerobiosis; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D004579:Electron Transport / Q000502:physiology; D005260:Female; D007202:Indicators and Reagents; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D013569:Synapses / Q000201:enzymology / Q000378:metabolism
chemical_list: D007202:Indicators and Reagents