title: Imipenem and meropenem induced resistance to beta-lactam antibiotics in Pseudomonas aeruginosa.
abstract: The ability of imipenem and meropenem in subinhibitory concentrations to influence the results of disk diffusion susceptibility tests was assessed. Selection of stably derepressed mutants resistant to beta-lactam antibiotics other than carbapenems was also investigated. Beta-lactams were shown to be subject to carbapenem-mediated antagonism in the disk diffusion test. On the other hand in vitro selection of stably derepressed mutants resistant to other beta-lactams could not be demonstrated.
authors.affiliation: Clinica delle Malattie Infettive, Ospedale Umberto I, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giacometti
authors.forename: F M
authors.initials: FM
authors.lastname: Siquini
authors.forename: O
authors.initials: O
authors.lastname: Cirioni
authors.forename: S
authors.initials: S
authors.lastname: Petroni
authors.forename: G
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D002876:Chromosomes, Bacterial; D004352:Drug Resistance, Microbial; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem