Nitric oxide-related pancreatic endocrine responses to hyperglycaemia in the conscious calf.
Mean plasma insulin concentration was reduced and mean plasma glucose concentration increased following the administration of N-nitro-L-arginine methyl ester (L-NAME; 100 mumol kg-1 i.a.) in conscious calves given continuous infusions of exogenous glucose (30-60 mumol min-1 kg-1 i.v.). It is concluded that the rise in plasma insulin concentration which occurs in these animals in response to glucose is mediated, at least in part, by a nitric oxide-related factor (NOx).
Edwards
A V
AV
Physiological Laboratory, University of Cambridge, UK.
Ghatei
M A
MA
Bloom
S R
SR
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D003243:Consciousness; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000502:physiology*; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D009569:Nitric Oxide; D001120:Arginine; D005947:Glucose; D019331:NG-Nitroarginine Methyl Ester