Glucagon-like peptide 1: a potent glycogenic hormone.
GLP-1(7-36)amide is an insulinotropic peptide derived from the intestinal post-translational proglucagon process, the release of which is increased mainly after a carbohydrate meal; also, its anti-diabetogenic effect in normal and diabetic states has been reported. In this study, GLP-1(7-36)amide stimulates the formation of glycogen from glucose in isolated rat hepatocytes, such a glycogenic effect being achieved with physiological concentrations of the peptide. The GLP-1(7-36)amide-induced glycogenesis is abolished by glucagon, and it is accompanied by stimulation of the glycogen synthase alpha activity and by a decrease in the basal and glucagon-stimulated cyclic AMP content. These findings could explain, at least in part, the GLP-1(7-36)amide insulin-independent plasma glucose lowering effect.
Valverde
I
I
Fundación Jiménez Díaz, Departamento de Metabolismo, Nutrición y Hormonas, Madrid, Spain.
Morales
M
M
Clemente
F
F
López-Delgado
M I
MI
Delgado
E
E
Perea
A
A
Villanueva-Peñacarrillo
M L
ML
D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D006003:Glycogen / Q000096:biosynthesis*; D006006:Glycogen Synthase / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D010455:Peptides; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D006003:Glycogen; D005934:Glucagon; C055454:glucagon-like peptide 1 (1-36)amide; D000242:Cyclic AMP; D006005:Phosphorylases; D006006:Glycogen Synthase