Structure and expression of the hairless gene of mice.
The hairless mutation of mice was caused by insertion of a murine leukemia virus. Starting with sequences flanking the provirus, a series of overlapping clones surrounding the viral integration site were obtained. By using a combination of sequencing, PCR, and exon-trapping techniques, the hairless gene was identified. It encodes a predicted protein of 1182 amino acids, including a potential zinc-finger domain. The expression patterns of the gene closely reflect the phenotype of animals carrying the hairless mutation.
Cachon-Gonzalez
M B
MB
National Institute for Medical Research, London, United Kingdom.
Fenner
S
S
Coffin
J M
JM
Moran
C
C
Best
S
S
Stoye
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D015870:Gene Expression; D017403:In Situ Hybridization; D009052:Leukemia Virus, Murine / Q000235:genetics; D051379:Mice; D008812:Mice, Hairless / Q000235:genetics*; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009154:Mutation; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D014018:Tissue Distribution; D014157:Transcription Factors; D016335:Zinc Fingers / Q000235:genetics
D011506:Proteins; D014157:Transcription Factors; C088661:hr protein, mouse