title: Effect of a lactoperoxidase containing toothpaste in radiation-induced xerostomia.
abstract: Fractioned irradiation of the oral region may cause xerostomia and an increased infection risk. The aim of this study was to evaluate, in a single blind, cross-over trial, the effectiveness of a test toothpaste containing the lactoperoxidase system, compared to a normal fluoridated toothpaste. Twelve patients with pronounced xerostomia were examined during a 52-day period. The following parameters were observed: plaque and gingivitis index, bleeding on probing, probing pocket depth, attachment level, and quality of subgingival plaque (phase contrast microscopy). The test toothpaste reduced the rate of supragingival plaque formation over a longer period. Furthermore, gingival inflammation was lower in the test group. For the other parameters, time-dependent changes were not significant. This pilot-study demonstrates the efficacy of the lactoperoxidase system administered by a toothpaste, on supragingival plaque control in xerostomic patients.
authors.affiliation: Department of Periodontology, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: van Steenberghe
authors.forename: E
authors.initials: E
authors.lastname: Van den Eynde
authors.forename: R
authors.initials: R
authors.lastname: Jacobs
authors.forename: M
authors.initials: M
authors.lastname: Quirynen
mesh_terms: D000328:Adult; D000368:Aged; D003774:Dental Plaque Index; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000473:pathology; D006801:Humans; D007784:Lactoperoxidase / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000473:pathology; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use; D010865:Pilot Projects; D017680:Potassium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D016037:Single-Blind Method; D014100:Toothpastes; D014987:Xerostomia / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; D014100:Toothpastes; C012980:fluorophosphate; D007784:Lactoperoxidase; D005459:Fluorides; C023844:potassium nitrate