[Effect of TRH and buzhong yiqi tang on natural killer cell activity and endocrine in stress mice].
Both thyrotropin-releasing hormone (TRH) and Buzhong Yiqi tang (BZYQT) were studied on their effect on splenic natural killer (NK) activity and hypothalamic-hypophyseal-thyroid (HHT) axis of stress mice. TRH (0.2 microgram/mouse/day, ip.) and BZYQT (0.2g/mouse/day, po.) had been given for 3 days before the amputation of right hind leg of mice were performed. Result showed that the TRH and BZYQT had rarely any effect on splenic NK activity and HHT axis recovery when they were used separately, but when used in combination they could increase the NK activity of splenic cells significantly in comparing with control group (from 8.32 +/- 4.50% to 15.60 +/- 4.18%, P < 0.05), while the HHT axis recovered to normal level at 24 hours after the amputation. The result suggests that there was a synergistic effect between TRH and BZYQT, and which exerted beneficial effect to the HHT axis stabilization and splenic NK activity recovery.
Tang
B
B
Dept. of Immunology, Wannan Medical College, Wuhu.
Wu
M Y
MY
D000673:Amputation, Traumatic / Q000150:complications; D000818:Animals; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D013315:Stress, Psychological / Q000097:blood / Q000276:immunology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D013973:Thyrotropin-Releasing Hormone