title: [Stimulation of wound healing with thrombocyte growth factors in treatment of chronic unhealed wounds].
abstract: The management of chronic wounds remains a challenge for various medical and surgical specialties. General strategies include local wound care, surgery, skin grafting, debridement, and vascular reconstruction. However, many wounds remain resistant to conventional therapies. Because platelet factors are important in the normal mechanism of wound healing, we report on the topical application of platelet-derived growth factor. Our initial results suggest that the topical application may stimulate and promote healing of chronic wounds.
authors.affiliation: Abteilung für Allgemeine Chirurgie und Poliklinik, Eberhard-Karls-Universität, Klinikum Schnarrenberg in Tübingen.
authors.forename: I
authors.initials: I
authors.lastname: Flesch
authors.forename: G
authors.initials: G
authors.lastname: Köveker
authors.forename: A
authors.initials: A
authors.lastname: Tolksdorf-Kremmer
authors.forename: S
authors.initials: S
authors.lastname: Coerper
authors.forename: H D
authors.initials: HD
authors.lastname: Becker
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D017719:Diabetic Foot / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage*; D016211:Transforming Growth Factor alpha / Q000008:administration & dosage*; D014647:Varicose Ulcer / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010982:Platelet-Derived Growth Factor; D016211:Transforming Growth Factor alpha
vernacular_title: Stimulation der Wundheilung mit thrombozytären Wachstumsfaktoren bei der Behandlung chronisch nicht-heilender Wunden.