[Role of sympathetic denervation in chemical carcinogenesis in the lungs in the pathogenesis of disorders of interleukin-1 production by alveolar macrophages].
Sympathetic innervation of the lungs and Interleukin-1 (IL-1) production by alveolar macrophages at urethan--induced carcinogenesis have been studied. The decreased of IL-1 production and visual signs of sympathectomy from the third month of carcinogenesis have been found. The injection of nerve growth factor at this period proved to prevent the process of sympathectomy and the decrease of IL-1 production. Production of IL-1 by macrophages was concluded to be regulated by sympathetic nervous system.
Lozhkin
I D
ID
Abramov
V V
VV
Shurlygina
A V
AV
Kozlov
V A
VA
D000236:Adenoma / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D007375:Interleukin-1 / Q000096:biosynthesis*; D008168:Lung / Q000294:innervation*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009414:Nerve Growth Factors / Q000494:pharmacology; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D014520:Urethane
D007375:Interleukin-1; D009414:Nerve Growth Factors; D014520:Urethane
O roli simpaticheskoĭ denervatsii pri khimicheskom kantserogeneze v legkikh v patogeneze narusheniia produktsii interleĭkina-1 al'veoliarnymi makrofagami.