title: Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis.
abstract: We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in patients with relapsing compared to those with stable disease (p < 0.001), but transforming growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable disease.
authors.affiliation: Department of Neurology, University of Göttingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Rieckmann
authors.forename: M
authors.initials: M
authors.lastname: Albrecht
authors.forename: B
authors.initials: B
authors.lastname: Kitze
authors.forename: T
authors.initials: T
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Tumani
authors.forename: A
authors.initials: A
authors.lastname: Broocks
authors.forename: W
authors.initials: W
authors.lastname: Lüer
authors.forename: S
authors.initials: S
authors.lastname: Poser
mesh_terms: D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000097:blood*
chemical_list: D016207:Cytokines; D012333:RNA, Messenger