title: Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder.
abstract: Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was used to examine whether reduced levels of phosphomonoesters (PME) were correlated with ventricular enlargement in 40 patients with bipolar disorder and 60 age-matched normal control subjects. Ventricular enlargement was assessed by magnetic resonance imaging (1H-MRI) using the following three methods: Evans ratio (ER), Huckman number (HN), and minimum distance of caudate nuclei (MDCN). Although MDCN and ER were significantly larger in the patient group, no significant correlations were found between 31P-MRS and 1H-MRI. PME was negatively correlated with age in bipolar disorder. Decreased levels of PME were found only in bipolar I disorder. Intracellular pH was positively correlated with duration of lithium treatment. These results suggest that the observed PME reduction was not related to ventricular enlargement, but the issue should be further studied with volumetric MRI analysis.
authors.affiliation: Department of Psychiatry, Shiga University of Medical Science, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Shioiri
authors.forename: J
authors.initials: J
authors.lastname: Murashita
authors.forename: H
authors.initials: H
authors.lastname: Hamakawa
authors.forename: T
authors.initials: T
authors.lastname: Inubushi
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D010755:Organophosphates / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D010755:Organophosphates; D010710:Phosphates; D010743:Phospholipids; D016651:Lithium Carbonate