Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder.
Prolactin and cortisol responses to buspirone, a partial serotonin agonist with effects on the 5-HT1A receptor, were measured in 16 patients with DSM-III-R obsessive-compulsive disorder (OCD) and 16 normal controls. No consistent differences were observed between patients and controls with respect to the hormone responses measured. The results suggest that dysfunction of the 5-HT1A receptor is not present in OCD patients. The limitations of buspirone as a specific agonist challenge of the 5-HT1A receptor are discussed. Although data from other studies generally support a serotonin dysfunction in OCD, the question of which specific subtype(s) of receptor remains unanswered.
Norman
T R
TR
Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia.
Apostolopoulos
M
M
Burrows
G D
GD
Judd
F K
FK
D000328:Adult; D002065:Buspirone / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects
D011985:Receptors, Serotonin; D011388:Prolactin; D002065:Buspirone; D006854:Hydrocortisone