title: Clinical correlates of body weight changes in schizophrenia.
abstract: Body weight was examined in chronic schizophrenic patients. Underweight medicated patients had normal ventricular brain ratios (VBRs) on CT. Overweight patients had both normal and abnormal VBRs. Weight decreased during neuroleptic withdrawal; caloric intake and weight increased when neuroleptics were reinstituted. Weight gain on neuroleptics correlated with symptom improvement independent of VBR or gender. Weight changes and psychosis in schizophrenia may be mediated by similar neurochemical systems.
authors.affiliation: Psychiatry Service, John L. McClellan Memorial Veterans Hospital, North Little Rock, Arkansas.
authors.forename: W B
authors.initials: WB
authors.lastname: Lawson
authors.forename: C N
authors.initials: CN
authors.lastname: Karson
mesh_terms: D000328:Adult; D001284:Atrophy; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000473:pathology; D002149:Energy Intake / Q000187:drug effects / Q000502:physiology; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology
chemical_list: D006220:Haloperidol