5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.
Dolle
R E
RE
Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
Dunn
J A
JA
Bobko
M
M
Singh
B
B
Kuster
J E
JE
Baizman
E
E
Harris
A L
AL
Sawutz
D G
DG
Miller
D
D
Wang
S
S
D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D010766:Phosphorylation; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D011804:Quinolines; C088968:5,7-dimethoxy-3-(4-pyridinyl)quinoline; D020794:Receptor Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor