title: A flexible random allocation program for multi-institutional clinical trials.
abstract: This paper describes a flexible random allocation program that assigns treatments to patients according to their prognostic factors in multi-institutional clinical trials. The source lists are available in the appendix of this paper. This program is based on Pocock and Simon's minimization method and Zelen's method for institution balancing. The numbers of institutions, treatments, and prognostic factors can be set arbitrarily. The maximum number of institutions, treatments, or prognostic factors that can be accommodated by the program is limited only by the size of the main memory. For example, an IBM-PC with a 640KB main memory can run a program of 1500 institutions, 4 treatments and 20 prognostic factors.
authors.affiliation: Department of Information Science, Faculty of Engineering, Fukui University.
authors.forename: T
authors.initials: T
authors.lastname: Odaka
authors.forename: K
authors.initials: K
authors.lastname: Akazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Nose
authors.forename: H
authors.initials: H
authors.lastname: Ogura
mesh_terms: D006801:Humans; D008838:Microcomputers; D015337:Multicenter Studies as Topic / Q000379:methods*; D011379:Prognosis; D011897:Random Allocation; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012984:Software