Curve fitting of labeled platelets: gamma model expanded for severe pathology.
To obtain an adequate curve fitting of labeled platelets also in case of severe pathology the multiple hit model of Murphy & Francis can be used, however, with addition of fractions of n (argument of the gamma function) and expansion of the domain of n towards zero and negative values. The 'hazard rate function' provides the instantaneous death rate for a platelet that has survived up to a given time. Applied to the multiple hit function, three kinds of hazard rate will be found: for n > 1 the death rate increases with age (absent or moderate pathology); for n = 1 the death rate is independent of age (death at random); for n < 1 the death rate decreases with age (probably severe pathology).
Golterman
A F
AF
Hospital Gelderse Vallei, Department of Internal Medicine, Bennekom, The Netherlands.
de Vries
R A
RA
van Stuivenberg
A
A
Gill
R D
RD
D000465:Algorithms; D001775:Blood Circulation / Q000502:physiology; D001791:Blood Platelet Disorders / Q000503:physiopathology; D001792:Blood Platelets / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010976:Platelet Count; D011868:Radioisotopes
D011868:Radioisotopes