[Changes in contents of aluminium, calcium and phosphorus contents of local bone after implantation of alumina endoprosthesis].
Thirty rabbits were divided equally into 5 groups randomly. A hole, 6mm in diameter and 2mm deep, was bored on both ilia of the thirty animals. Two cubes of alumina were implanted into the hole on one side of each animal, while the hole on the opposite side served as control. Six rabbits each were sacrificed on 10, 20, 40, 60 and 90 days after operation. Calcium, phosphorus and aluminium contents of bone tissues in and around both holes were determined by Inductively Coupled Plasma-Atomic Emission Spectrometry. The results show that the aluminium content of the bone tissues on the implanted side in each group was higher than that of the control with statistically significant difference in the 10-, 40- and 60-day groups (P < 0.05). This means that the implantation definitely releases aluminium into the bone tissues. On the contrary, calcium and phosphorus contents were significantly lower in the bone tissues on the implanted side than in the control side in the 10- and 20-day groups (P < 0.05-0.001). It implies that the aluminium released from the implant in the early stage can interfere with the metabolism of calcium and phosphorus and thus delay the mineralization of the bone tissues.
Wang
Z X
ZX
Ruijin Hospital, Shanghai Second Medical University.
Chai
B F
BF
Ye
Y Q
YQ
D000535:Aluminum / Q000378:metabolism*; D000537:Aluminum Oxide / Q000009:adverse effects*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism* / Q000601:surgery; D002113:Calcification, Physiologic / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism*; D019736:Prostheses and Implants; D011817:Rabbits
D010758:Phosphorus; D000535:Aluminum; D000537:Aluminum Oxide; D002118:Calcium