[Decrease of toxic effects of aminothiol radiation-protective agents and increase of chemical protection action against ionizing radiation by the use of unithiol].
It has been shown that unithiol diminishes toxic action of cysteamine, AET, and disulfide of WR-1065 on mice. This permits to enhance protection of animals against X-rays by increasing of protector doses. The effect of unithiol on cysteamine action in rats was the same. Antitoxic effect of unithiol on cysteamine was shown both at i.p. and p.o. protector administration. The effect was also revealed in Chinese hamster V-79 cell culture. Combined disulfide of cysteamine and unithiol was synthetized, which ensures effective prolonged protection against ionizing radiation.
Grachev
S A
SA
Sverdlov
A G
AG
Nikanorova
N G
NG
Bol'shakova
O I
OI
Korolva
I K
IK
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003538:Cystamine / Q000633:toxicity; D003543:Cysteamine / Q000633:toxicity; D008624:Mercaptoethylamines / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000633:toxicity*; D051381:Rats; D014494:Unithiol / Q000008:administration & dosage / Q000494:pharmacology*; D000338:beta-Aminoethyl Isothiourea / Q000633:toxicity
D008624:Mercaptoethylamines; D011837:Radiation-Protective Agents; C020174:N-(2-mercaptoethyl)-1,3-diaminopropane; D000338:beta-Aminoethyl Isothiourea; D014494:Unithiol; D003543:Cysteamine; D003538:Cystamine
Snizhenie toksicheskogo deĭstviia aminotiolovykh radioprotektorov i povyshenie éffekta khimicheskoĭ zashchity ot ioniziruiushcheĭ radiatsii s pomoshchiu unitiola.