title: Feasibility of invasive monitoring of intracranial pressure in term neonates.
abstract: Seven term neonates with encephalopathy resulting from asphyxia and/or intracranial hemorrhage underwent invasive monitoring of intracranial pressure through the epidural or intracerebral space. The average age (in hours) at insertion of the monitor was 27 h in the 3 neonates with asphyxia and 70 h in the 4 neonates with hemorrhage. Intracranial hypertension was noted in 6 neonates. The management of the hypertension included hyperventilation followed by mannitol for pressures that were sustained above 20 mmHg and pentobarbital for pressures above 30 mmHg. The duration of the hypertension varied in 5 neonates from 4 to 72 h, while in the remaining neonates, the pressure remained elevated until death at 70 h. All 4 survivors with intracranial hemorrhage have minimal neuromotor deficits on follow up and 2 survivors with asphyxia have cognitive deficits and are microcephalic. From this small series, it appears that in the management of term neonates with intracranial hemorrhage, monitoring of intracranial pressure should be considered.
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit 48201.
authors.forename: S
authors.initials: S
authors.lastname: Shankaran
authors.forename: E
authors.initials: E
authors.lastname: Woldt
authors.forename: M P
authors.initials: MP
authors.lastname: Bedard
authors.forename: V
authors.initials: V
authors.lastname: Delaney-Black
authors.forename: K
authors.initials: K
authors.lastname: Zakalik
authors.forename: A
authors.initials: A
authors.lastname: Canady
mesh_terms: D001237:Asphyxia / Q000150:complications / Q000503:physiopathology; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000503:physiopathology; D004824:Epidural Space / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007427:Intracranial Pressure / Q000502:physiology*; D008353:Mannitol / Q000627:therapeutic use; D008991:Monitoring, Physiologic; D010424:Pentobarbital / Q000627:therapeutic use; D012306:Risk
chemical_list: D008353:Mannitol; D010424:Pentobarbital