Use and abuse of analgesics in tension-type headache.
Eighty patients suffering from tension-type headache for an average of 21 years were asked to report on all drugs they had ever taken (type, dosage, duration of intake, efficacy) or were taking currently. The patients had consumed on average 6.3 different drugs. The cumulative doses of derivatives of para-aminophenol, pyrazolone, and salicylic acid in some cases reached a maximum of several kilograms. Most drugs were classified by the patients as "moderately effective". The rating "very effective" was assigned primarily to barbiturates; however, barbiturates are no longer used as components of compound analgesic drugs in Austria. At the time of investigation, patients consumed 2.5 (mean) different drugs, primarily as compound preparations. Seventeen patients (21%) showed signs of possible analgesics- or ergotamine-induced headache and were therefore advised to undergo withdrawal therapy. Our results show that patients with tension-type headache are at considerable risk of becoming drug-dependent and of acquiring analgesics-induced headache.
Schnider
P
P
Neurological University Clinic, Vienna, Austria.
Aull
S
S
Feucht
M
M
Mraz
M
M
Travniczek
A
A
Zeiler
K
K
Wessely
P
P
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D004878:Ergotamine / Q000009:adverse effects; D005260:Female; D006261:Headache / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013312:Stress, Physiological / Q000150:complications*; D019966:Substance-Related Disorders
D000700:Analgesics; D004878:Ergotamine