title: Stability of an extemporaneously compounded cisapride suspension.
abstract: The purpose of the study was to formulate a cisapride suspension that would be stable under usual storage conditions for 3 weeks. Cisapride is a new prokinetic agent that is available as a coated tablet; occasionally, however, patients require a liquid preparation of cisapride. Cisapride was formulated with propylene glycol to enhance its solubility. The suspension was buffered with sodium bicarbonate to produce a pH between 6.5 and 7.5. The formulation provided a cisapride suspension that was stable at room temperature for 3 weeks.
authors.affiliation: School of Pharmacy, University of Washington, Seattle.
authors.forename: J R
authors.initials: JR
authors.lastname: Horn
authors.forename: G D
authors.initials: GD
authors.lastname: Anderson
mesh_terms: D000975:Antioxidants; D002021:Buffers; D002626:Chemistry, Pharmaceutical; D020117:Cisapride; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010277:Parasympathomimetics / Q000737:chemistry* / Q000592:standards; D014677:Pharmaceutical Vehicles; D010880:Piperidines / Q000737:chemistry* / Q000592:standards; D019946:Propylene Glycol; D011409:Propylene Glycols; D017693:Sodium Bicarbonate; D012995:Solubility; D013535:Suspensions; D013696:Temperature
chemical_list: D000975:Antioxidants; D002021:Buffers; D010277:Parasympathomimetics; D014677:Pharmaceutical Vehicles; D010880:Piperidines; D011409:Propylene Glycols; D013535:Suspensions; D019946:Propylene Glycol; D017693:Sodium Bicarbonate; D020117:Cisapride