Relationship between superoxide dismutase and melanin in a pathogenic fungus.
Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.
Jacobson
E S
ES
Research Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249.
Jenkins
N D
ND
Todd
J M
JM
D003455:Cryptococcus neoformans / Q000378:metabolism* / Q000472:pathogenicity; D008543:Melanins / Q000378:metabolism*; D014442:Monophenol Monooxygenase / Q000378:metabolism; D009154:Mutation; D013482:Superoxide Dismutase / Q000378:metabolism*; D013696:Temperature
D008543:Melanins; D014442:Monophenol Monooxygenase; D013482:Superoxide Dismutase