title: Fatal group A streptococcal meningitis and toxic shock-like syndrome: case report.
abstract: A previously healthy 8-year-old girl presented with flu-like symptoms, developed toxic shock-like syndrome, and died within 48 hours. At autopsy she was found to have purulent meningitis. The group A beta-hemolytic streptococcus isolated from her CSF was a member of clone ET 2. This strain produced a variant form of streptococcal pyrogenic exotoxin A (SPEA 2) that has recently been associated with widespread toxic shock-like syndrome.
authors.affiliation: Department of Pathology, Texas Children's Hospital, Houston.
authors.forename: G P
authors.initials: GP
authors.lastname: Jevon
authors.forename: W M
authors.initials: WM
authors.lastname: Dunne
authors.forename: H K
authors.initials: HK
authors.lastname: Hawkins
authors.forename: D L
authors.initials: DL
authors.lastname: Armstrong
authors.forename: J M
authors.initials: JM
authors.lastname: Musser
mesh_terms: D001921:Brain / Q000382:microbiology / Q000473:pathology; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000382:microbiology* / Q000473:pathology; D012772:Shock, Septic / Q000134:cerebrospinal fluid / Q000382:microbiology*; D013290:Streptococcal Infections / Q000134:cerebrospinal fluid / Q000473:pathology; D013297:Streptococcus pyogenes