Dietary menhaden oil contributes to hepatic lipidosis in laying hens.
Clinical and epidemiological investigations have indicated that there may be substantial human cardiovascular benefits associated with increased consumption of n-3 fatty acids commonly found in fish oils. Recent studies have indicated that egg yolk n-3 fatty acid content is significantly increased when hens are fed diets enriched with selected fish oils such as menhaden oil (MO). In the present study, reproductively active females but not males exhibited increased hepatic lipidosis following 6 mo of feeding 3% MO. Hens fed 3% animal-vegetable oil (AV) did not exhibit hepatic lipid accumulation. Serum triglyceride and cholesterol concentrations were reduced (P < or = .05) in hens fed MO. Subsequently, yolk and total egg weights of hens fed MO were decreased as compared with those of hens fed AV. A significant interaction of dietary MO and exogenous 17 beta-estradiol was noted among chick liver and gallbladder weights. These data suggest that dietary MO and estradiol may interact in a manner that enhances the lipogenic activity of the liver, thereby inducing hepatic lipidosis in laying hens.
Van Elswyk
M E
ME
Department of Poultry Science, Texas Agricultural Experiment Station, Texas A&M University System, College Station 77843-2472.
Hargis
B M
BM
Williams
J D
JD
Hargis
P S
PS
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002645:Chickens; D004530:Egg Yolk / Q000737:chemistry / Q000187:drug effects; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D008064:Lipidoses / Q000139:chemically induced / Q000662:veterinary*; D008055:Lipids / Q000032:analysis; D008107:Liver Diseases / Q000662:veterinary*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010058:Oviposition / Q000187:drug effects; D011201:Poultry Diseases / Q000139:chemically induced*
D005395:Fish Oils; D008055:Lipids; C033266:Menhaden oil