title: Mediastinal lymph node metastasis from lung cancer: evaluation with Tl-201 SPECT--comparison with CT.
abstract: OBJECTIVE
  To assess the usefulness of thallium-201 single photon emission computed tomography (SPECT) in detection of mediastinal lymph node metastasis from lung cancer.
  
  
  METHODS
  Computed tomography (CT) and Tl-201 SPECT were performed in 113 patients with lung cancer. Surgical staging was performed in all patients, and the results of the two modalities were compared with the pathologic findings in 364 node stations.
  
  
  RESULTS
  Cancerous nodes were found in 32.7% of the patients. The sensitivity of CT in detecting mediastinal node metastasis was 62%; specificity was 80%. These rates were higher for Tl-201 SPECT (76% and 92%, respectively). Furthermore, these rates were excellent in patients with enlarged mediastinal nodes at CT (87% and 93%, respectively). However, Tl-201 SPECT had more limited spatial resolution than did CT.
  
  
  CONCLUSIONS
  Tl-201 SPECT is useful in evaluation of mediastinal node metastasis in lung cancer, especially for patients with enlarged nodes at CT.
authors.affiliation: Division of Thoracic Diseases, Tochigi Cancer Center, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yokoi
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
authors.forename: N
authors.initials: N
authors.lastname: Miyazawa
authors.forename: I
authors.initials: I
authors.lastname: Takizawa
authors.forename: M
authors.initials: M
authors.lastname: Sasagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D013794:Thallium Radioisotopes