Acetylsalicylic acid--inducer of cytochrome P-450 2E1?
Pretreatment of rats with acetylsalicylic acid or sodium salicylate stimulates the metabolism of dichloromethane to carbon monoxide as measured by the carboxyhemoglobin level in blood. Simultaneous administration of dichloromethane and acetylsalicylic acid or sodium salicylate, respectively, was accompanied by reduced carboxyhemoglobin formation. In liver microsomes of rats pretreated with acetylsalicylic acid the p-nitrophenol hydroxylase activity was increased. It is concluded that (i) cytochrome P-450 2E1 is involved in the metabolic conversion of both dichloromethane and salicylic acid, and (ii) salicylic acid may be an inducer of cytochrome P-450 2E1.
Pankow
D
D
Institut für Pharmakologie und Toxikologie, Bereich Umwelttoxikologie der Martin-Luther-Universität Halle-Wittenberg, Halle Saale, Germany.
Damme
B
B
Schrör
K
K
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002263:Carboxyhemoglobin / Q000187:drug effects; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000187:drug effects*; D004790:Enzyme Induction; D008297:Male; D008752:Methylene Chloride / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects; D006899:Mixed Function Oxygenases / Q000187:drug effects; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid
D012459:Salicylates; D008752:Methylene Chloride; D003577:Cytochrome P-450 Enzyme System; D002263:Carboxyhemoglobin; D006899:Mixed Function Oxygenases; D019392:Cytochrome P-450 CYP2E1; D010089:Oxidoreductases, N-Demethylating; D020156:Salicylic Acid; D001241:Aspirin