Blockers of Ca2+ channels in the plasmalemma of perfused Characeae cells.
Ionic currents in the plasmalemma of perfused Nitella syncarpa cells identified as currents through Ca2+ channels were registered for the first time. The effect of 1,4-dihydropyridine derivatives (nifedipine, nitrendipine, riodipine) and phenylalkylamines (verapamil, D600) as well as the agonist CGP-28392 on the Ca2+ channels in the plasmalemma of perfused cells of Nitellopsis obtusa and Nitella syncarpa have been studied. A blocking effect of 1,4-dihydropyridine derivatives and phenylalkylamines on the plasmalemma Ca2+ channels has been detected. Phenylalkylamines have been found to block both inward and outward Ca2+ currents. The activating effect of the agonist CGP-28392 on the Ca2+ channels of plasmalemma has been shown.
Zherelova
O M
OM
Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region, Russia.
Grishchenko
V M
VM
Chaylakhyan
L M
LM
D002120:Calcium Channel Agonists / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects; D000460:Chlorophyta / Q000187:drug effects*; D004095:Dihydropyridines / Q000494:pharmacology; D008564:Membrane Potentials; D009543:Nifedipine / Q000494:pharmacology; D009568:Nitrendipine / Q000494:pharmacology; D010477:Perfusion; D011725:Pyridines / Q000494:pharmacology
D002120:Calcium Channel Agonists; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D004095:Dihydropyridines; D011725:Pyridines; C038806:1,4-dihydropyridine; C040525:CGP 28392; D009568:Nitrendipine; D009543:Nifedipine