Polysialic acid expression in the salamander retina is inducible by thyroxine.
Polysialylation of the neural cell adhesion molecule (NCAM) in the retina of Pleurodeles waltl is up-regulated during metamorphosis. Incubation of larvae in thyroxine permanently induced polysialic acid expression in the retina in a concentration-dependent but age-independent manner within 3 days of incubation (3 x 10(-7) M). Retinoic acid had no effect. This suggests direct hormonal regulation of a post-translational modification of NCAM in the amphibian retina.
Becker
C G
CG
Brain Research Institute, University of Bremen, Germany.
Becker
T
T
Schmidt
A
A
Roth
G
G
D000375:Aging / Q000378:metabolism; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D007814:Larva; D010999:Pleurodeles; D011134:Polysaccharides / Q000096:biosynthesis*; D011499:Protein Processing, Post-Translational; D012160:Retina / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D012794:Sialic Acids / Q000096:biosynthesis*; D013974:Thyroxine / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology
D015816:Cell Adhesion Molecules, Neuronal; D011134:Polysaccharides; D012794:Sialic Acids; C021319:polysialic acid; D014212:Tretinoin; D013974:Thyroxine