title: [Oral premedication with clonidine in patients undergoing coronary revascularization surgery].
abstract: OBJECTIVE
  To analyze the effect of premedication with clonidine on level of sedation, anesthetic requirements and hemodynamic repercussions in patients undergoing coronary revascularization.
  
  
  METHODS
  Thirty patients were divided into two groups and randomly assigned for premedication with clonidine 0.005 mg/kg p.o. (C) or lorazepam 0.03 mg/kg p.o. (L), along with morphine 0.15 mg/kg i.m. and scopolamine 0.005 mg/kg i.m. in a prospective double-blind study. The level of sedation before surgery and anesthetic requirements in the two groups were compared, as were systolic and diastolic arterial pressure, heart rate and hemodynamics during and after surgery. Fentanyl was used for anesthetic induction in boluses of 0.15 mg every 10 seconds; maintenance boluses of 0.5 mg were used up to a maximum dose of 0.07 mg/kg. If hemodynamic variables analyzed (systolic and diastolic arterial pressure and heart rate) were not kept within 30% of baseline values with this regimen, isoflurane was added.
  
  
  RESULTS
  No differences between the two groups were found for level of sedation. The total dose of fentanyl was lower in group C (0.052 +/- 0.002 mg/kg vs 0.058 +/- 0.002 mg/kg) (p < 0.05). The number of patients requiring isoflurane was similar (4/11 and 6/9) in both groups. The hemodynamic profile prior to extracorporeal circulation (ECC) revealed arterial pressures and heart rates to be lower in the group treated with clonidine (p < 0.05); after ECC systemic resistance in group C was lower (630 +/- 103 vs 795 +/- 106 din.s.cm-5) (p < 0.05) and this was not compensated for by a significant rise in cardiac index (2.62 +/- 0.09 vs 2.40 +/- 0.08 l/min/m2) at similar occlusion pressures.
  
  
  CONCLUSIONS
  Use of clonidine in the type of patient studied does not improve the level of sedation over that achieved with lorazepam. Fentanyl requirements decreased with clonidine. With respect to hemodynamic profile, systemic vascular resistance fell in the clonidine group after removal of ECC, and thus this drug offers no advantages for routine premedication.
authors.affiliation: Servicio de Anestesiología y Reanimación, Hospital Puerta de Hierro, Madrid.
authors.forename: M
authors.initials: M
authors.lastname: García-Guiral
authors.forename: S
authors.initials: S
authors.lastname: García del Valle
authors.forename: A
authors.initials: A
authors.lastname: Carrera
authors.forename: M V
authors.initials: MV
authors.lastname: Martínez
authors.forename: M J
authors.initials: MJ
authors.lastname: Arribas
authors.forename: A
authors.initials: A
authors.lastname: Escarpa
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000768:Anesthesia, General; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D011229:Preanesthetic Medication; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D003000:Clonidine; D008140:Lorazepam; D005283:Fentanyl
vernacular_title: Premedicación oral con clonidina en enfermos sometidos a cirugía de revascularización coronaria.