Selective antagonism of the anticonvulsant effects of felbamate by glycine.
Glycine blocked the anticonvulsant effects of felbamate on electroshock- and NMDA-induced seizures in mice. In contrast to its effects on felbamate, glycine either potentiated or had no effect on the anticonvulsant actions of phenytoin, valproate, carbamazepine and phenobarbital on electroshock seizures in mice. The data support that the glycine-felbamate blockade is a specific interaction. Felbamate is likely to be the first clinically available anticonvulsant drug that acts through this unique mechanism.
Coffin
V
V
Schering-Plough Research Institute, Kenilworth, NJ 07033-0539.
Cohen-Williams
M
M
Barnett
A
A
D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D000078328:Felbamate; D005998:Glycine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016202:N-Methylaspartate; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D016202:N-Methylaspartate; D005998:Glycine; D000078328:Felbamate