The potent depressant effects of N3-phenacyluridine in mice.
The hypnotic activity of N3-phenacyluridine in 2.0 mumol/mouse by intracerebroventricular (i.c.v.) injection was 20 times stronger than that of known N3-benzyluridine. In 0.5 mumol/mouse, i.c.v., this compound strongly potentiated both pentobarbital- and diazepam-induced sleep as compared to N3-substituted uridines, including N3-benzyluridine. Furthermore, the compound caused motor incoordination as well as decreasing spontaneous activity in the same dose. These results indicate that among the N3-substituted uridines and related compounds previously reported, N3-phenacyluridine possesses potent depressant effects.
Yamamoto
I
I
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Kuze
J
J
Kimura
T
T
Watanabe
K
K
Kondo
S
S
Ho
I K
IK
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D014529:Uridine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D006993:Hypnotics and Sedatives; C089028:N(3)-phenacyluridine; D010424:Pentobarbital; D003975:Diazepam; D014529:Uridine