[The role of invertors in the mechanism of heart function regulation].
Decrease of heart contraction function and rate, diminish of adreno- and fluoride-sensitivity of adenylate cyclase was detected under the long-time isolated rat's heart Langendorff's perfusion. Injection of rat with the Actinomycin D (an inhibitor of transcription) prevented the decline of hearts' function and adenylate cyclase activity. The addition of cytosol from cells of long-term perfused heart decreased the adrenosensitivity of adenylate cyclase of intact animal heart membranes. Actinomycin D prevented this effect. The appearance of cellular factor, which down-regulates adenylate cyclase activity (named by us an invertor) into the heart under the long-time perfusion is discussed.
Frol'kis
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Matrenitskiĭ
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D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology; D004789:Enzyme Activation; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D003609:Dactinomycin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase
Rol' invertorov v mekhanizme reguliatsii funktsii serdtsa.