title: Timing and rate of sexual maturation and the onset of cigarette and alcohol use among teenage girls.
abstract: OBJECTIVE
  To test the hypothesis that the patterns of pubertal progression, early vs late puberty and fast vs slow, are associated with the age at which girls start to drink alcohol and smoke cigarettes.
  
  
  METHODS
  The study included 1463 female students, 10.7 to 18.2 years of age, who were assessed five times during the 2.7-year study. Data regarding pubertal stage, alcohol use, and cigarette use were obtained at each assessment. These data were used to calculate two indexes of pubertal development, the age at which the midpoint of puberty was achieved and the rate of progression through puberty, and the ages when each subject first drank, first drank moderate amounts of alcohol, and first smoked.
  
  
  RESULTS
  Girls with earlier puberty (midpoint < 12.2 years) first reported drinking any alcohol at a median age of 12.5 years, 0.7 years younger than girls whose puberty was later. Similarly, girls with earlier puberty reported drinking moderate amounts of alcohol at a median age of 13.7 years, 0.9 years younger than girls with later puberty. Girls with earlier puberty further reported first smoking cigarettes at a median age of 12.8 years, 0.6 years younger than girls with later puberty. The rate of pubertal progression was significantly associated only with the age when girls first drank moderate amounts of alcohol.
  
  
  CONCLUSIONS
  Earlier puberty is associated with a younger age of onset for both drinking and smoking among adolescent girls.
authors.affiliation: Department of Pediatrics, Stanford (Calif) University.
authors.forename: D M
authors.initials: DM
authors.lastname: Wilson
authors.forename: J D
authors.initials: JD
authors.lastname: Killen
authors.forename: C
authors.initials: C
authors.lastname: Hayward
authors.forename: T N
authors.initials: TN
authors.lastname: Robinson
authors.forename: L D
authors.initials: LD
authors.lastname: Hammer
authors.forename: H C
authors.initials: HC
authors.lastname: Kraemer
authors.forename: A
authors.initials: A
authors.lastname: Varady
authors.forename: C B
authors.initials: CB
authors.lastname: Taylor
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000367:Age Factors; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000523:psychology; D002648:Child; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D011627:Puberty / Q000502:physiology* / Q000523:psychology; D012307:Risk Factors; D012741:Sexual Maturation / Q000502:physiology*; D012907:Smoking / Q000453:epidemiology* / Q000523:psychology; D013997:Time Factors