title: Factors affecting survival of patients with tumors of the anterior skull base.
abstract: Fifty-four patients with primary neoplasms of the anterior skull base were treated by craniofacial resection with curative intent. The most common tumor was esthesioneuroblastoma (24), followed by squamous cell carcinoma (10). The overall 2-year and 5-year survivals were 75% and 49%, respectively. High-grade tumors, grades 3 and 4, had a poorer prognosis. Tumor size, dural involvement, sphenoid sinus involvement, age, and sex had no significant influence on survival when examined by multivariate survival analysis. Sixteen complications were noted in the postoperative period. Cerebrospinal fluid leakage occurred in 2 patients and loss of frontal bone occurred in 4. There were no operative or perioperative deaths. Craniofacial resection permits surgical resection of the majority of anterior skull base tumors with acceptable morbidity.
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905.
authors.forename: T V
authors.initials: TV
authors.lastname: McCaffrey
authors.forename: K D
authors.initials: KD
authors.lastname: Olsen
authors.forename: J M
authors.initials: JM
authors.lastname: Yohanan
authors.forename: J E
authors.initials: JE
authors.lastname: Lewis
authors.forename: M J
authors.initials: MJ
authors.lastname: Ebersold
authors.forename: D G
authors.initials: DG
authors.lastname: Piepgras
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003399:Craniotomy / Q000379:methods; D018304:Esthesioneuroblastoma, Olfactory / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009918:Orbital Neoplasms / Q000473:pathology; D011183:Postoperative Complications; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome