title: Aortic distensibility in post-menopausal women receiving Tibolone.
abstract: Both oestrogen and androgens have been shown to affect the structural composition and biophysical properties of the arterial wall in vitro. A non-invasive Doppler ultrasound technique, based on the measurement of pulse wave velocity along the thoraco-abdominal aortic pathway, was used to assess aortic compliance C in vivo in 49 normotensive, normal, healthy post-menopausal female subjects. 23 of the women had been receiving Tibolone, a synthetic steroid structurally related to norethisterone, for at least 3 years. Since C varies with non-chronic changes in blood pressure, an index of intrinsic aortic distensibility, Cp, normally independent of blood pressure, was also calculated. No significant difference was found between the control group and those subjects receiving Tibolone for age, body mass index, systolic blood pressure, diastolic blood pressure, C or Cp. As one would expect the control group Cp values did not show a significant relationship with blood pressure (r = -0.1, not significant). However, in the Tibolone group some dependence of Cp values on pressure still remained (r = -0.58, p < 0.004), suggesting that oral administration of Tibolone had altered the dynamic relationship between structural and functional biophysical properties of the aortic wall in vivo.
authors.affiliation: Division of Radiological Sciences, U.M.D.S. (University of London), Guy's Hospital, UK.
authors.forename: E D
authors.initials: ED
authors.lastname: Lehmann
authors.forename: K D
authors.initials: KD
authors.lastname: Hopkins
authors.forename: J R
authors.initials: JR
authors.lastname: Parker
authors.forename: R C
authors.initials: RC
authors.lastname: Turay
authors.forename: J
authors.initials: J
authors.lastname: Rymer
authors.forename: I
authors.initials: I
authors.lastname: Fogelman
authors.forename: R G
authors.initials: RG
authors.lastname: Gosling
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use*; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000187:drug effects*; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D015331:Cohort Studies; D003187:Compliance; D005260:Female; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D017698:Postmenopause; D014463:Ultrasonography
chemical_list: D045930:Anabolic Agents; D009652:Norpregnenes; C027385:tibolone