Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients.
We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.
Doi-Yi
R
R
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Kitamoto
T
T
Ogomori
K
K
Mehraein
P
P
Tateishi
J
J
D000328:Adult; D000368:Aged; D044466:Asian People; D007562:Creutzfeldt-Jakob Syndrome / Q000208:ethnology* / Q000378:metabolism* / Q000473:pathology; D005858:Germany / Q000208:ethnology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007564:Japan / Q000208:ethnology; D008875:Middle Aged; D010487:Periaqueductal Gray / Q000378:metabolism; D011328:Prions / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure; D014018:Tissue Distribution; D044465:White People
D011328:Prions