Elevation of serum M-CSF concentrations during pregnancy and ovarian hyperstimulation.
Macrophage colony stimulating factor (CSF-1 or M-CSF) is involved in haemopoiesis and probably in mouse gestation. Sexual steroids induce its production by uterine glandular epithelial cells and its receptor (product of the protooncogene C-FMS) is expressed on placental trophoblastic cells. We measured M-CSF serum levels in 119 pregnant women and in eight women undergoing ovarian hyperstimulation for in vitro fertilization. M-CSF increased early (4-8 weeks) and progressively during gestation. Its rapid elevation during the course of ovarian hyperstimulation suggests that its synthesis is probably induced by sexual steroids. This locally produced M-CSF could play a role in human pregnancy and in the pathogenesis of thrombocytopenias observed during pregnancy.
Praloran
V
V
Laboratoire d'Hématologie Expérimentale, Faculté de Médecine, Limoges, France.
Coupey
L
L
Donnard
M
M
Berrada
L
L
Naud
M F
MF
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D009000:Monocytes / Q000166:cytology; D010062:Ovulation Induction; D010976:Platelet Count; D011247:Pregnancy / Q000097:blood*
D016173:Macrophage Colony-Stimulating Factor