Acute dietary PCPA treatment decreases the KD of brain [3H]5-HT binding in rainbow trout, Oncorhynchus mykiss, fed a high carbohydrate diet.
Two experiments were conducted to determine the effect of dietary PCPA on brain [3H]5-HT binding in rainbow trout. [3H]5-HT binding was quantitatively similar to that observed in mammalian species. Dietary treatment with PCPA had no effect on the Bmax of [3H]5-HT binding in either experiment while the KD was decreased in Experiment 1. These results demonstrate that [3H]5-HT binding affinity is increased following short term inhibition of 5-HT synthesis by PCPA in rainbow trout.
Johnston
W L
WL
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
Glanville
N T
NT
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D010134:Fenclonine / Q000008:administration & dosage / Q000494:pharmacology*; D017686:Oncorhynchus mykiss; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D014316:Tritium
D004040:Dietary Carbohydrates; D011985:Receptors, Serotonin; D014316:Tritium; D012701:Serotonin; D010134:Fenclonine