Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine.
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae, chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient mutants. The petite clones that were analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome.
Krivjanský
V
V
Department of Microbiology and Virology, Faculty of Sciences, Comenius University, Bratislava, Slovak Republic.
Obernauerová
M
M
Ulrichová
J
J
Simánek
V
V
Subík
J
J
D000470:Alkaloids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D053119:Benzophenanthridines; D004272:DNA, Mitochondrial / Q000187:drug effects; D007546:Isoquinolines; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics*; D010101:Oxygen Consumption / Q000187:drug effects / Q000235:genetics*; D010617:Phenanthridines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D053119:Benzophenanthridines; D004272:DNA, Mitochondrial; D007546:Isoquinolines; D010617:Phenanthridines; C005705:sanguinarine; C016299:chelerythrine