title: [Benzo(a)pyrene induces planocellular metaplasia of the respiratory epithelium in explants of embryonic mouse lung].
abstract: The direct effect of benz(a)pyrene (BP) induces squamous epithelial metaplasia (SEM) in organ cultures from embryonic lungs of C57BL and A. The incidence of SEM depend on the doses of BP (3-6-12 mkg/ml), duration of treatment and on the mice line.
authors.forename: T S
authors.initials: TS
authors.lastname: Kolesnichenko
authors.forename: T G
authors.initials: TG
authors.lastname: Gor'kova
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D008168:Lung / Q000196:embryology / Q000473:pathology*; D008679:Metaplasia / Q000139:chemically induced; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques; D013045:Species Specificity
chemical_list: D001564:Benzo(a)pyrene
vernacular_title: Benz(a)piren indutsiruet ploskokletochnuiu metaplaziiu respiratornogo épiteliia v éksplantatakh émbrional'nykh legkikh mysheĭ.