[Morphologic changes of erythrocytes in mice and rats exposed to organophosphate cholinesterase inhibitors].
Initial stages of animal poisoning with phosphacole and carbophos are accompanied by growth of erythrocytes in size and considerable changes of their surface shape, which disappear in 15 min--4 hrs regardless of the remaining cholinesterase activity inhibition. The phenomenon of erythrocytes' deformation is reproducible in in vitro experiments under the conditions of simultaneous inhibition of cholinesterase activity and exposure to acetylcholine with concentration of 1 x 10(-8) M and higher.
Prozorovskiĭ
V B
VB
Skopichev
V G
VG
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D008294:Malathion / Q000506:poisoning; D008297:Male; D051379:Mice; D062025:Organophosphate Poisoning; D010261:Paraoxon / Q000506:poisoning; D051381:Rats
D002800:Cholinesterase Inhibitors; D000109:Acetylcholine; D010261:Paraoxon; D008294:Malathion
Morfologicheskie izmeneniia éritrotsitov mysheĭ i krys pri vozdeĭstvii fosfororganicheskimi inhibitorami kholinésteraz.