Inhibition of cytokine release by cocaine.
The influence of cocaine on cytokine release by mouse peritoneal macrophages has been investigated in vitro. LPS-stimulated TNF and IL-1 secretion were suppressed by cocaine in higher dosages. This suppression was shown to be dose-related. The synthesis of cAMP, however, was stimulated by cocaine. Though cAMP is generally considered a mediator for cytokine release, further studies are required to demonstrate whether cocaine directly affects cytokine release by macrophages or indirectly influences cytokine release through stimulating cAMP synthesis.
Shen
H M
HM
Department of Pathology, College of Medicine, University of Illinois at Chicago 60612.
Kennedy
J L
JL
Ou
D W
DW
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D013950:Thymus Gland / Q000166:cytology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D003042:Cocaine