Effects of sleep on the antidepressant response to sleep deprivation.
The effect of a 90-min nap period on mood was studied in 22 sleep-deprived patients with a diagnosis of major depression. All patients remained awake from 7 AM until 12 noon the following day at which time they were permitted to nap while being monitored by sleep encephalography. Fifteen subjects showed a significant response to sleep deprivation as defined by a 35% improvement on the Hamilton Rating Scale for Depression. After the nap a relapse of depressive symptoms occurred which was significantly related to the amount of non-rapid eye movement sleep time.
Reist
C
C
Psychiatry Service, Veterans Affairs Medical Center, Long Beach, CA 90822.
Chen
C C
CC
Chhoeu
A
A
Berry
R B
RB
Bunney
W E
WE
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D017286:Polysomnography; D012892:Sleep Deprivation / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology