[Age-related changes in the dopaminergic system in rat striatum].
The dopaminergic neurochemical parameters of the adult (3 months) rat's striata in comparison with those of aged (26 months) ones were studied using HPLC/ED method. It was shown that Dopamine (DA) and its intracellular metabolite DOPAC content increase in striatal homogenates of aged rats up to 153 and 165%, accordingly. The level of other metabolite--HVA, as well as intensity of basal DA efflux from perfused isolated striata decreased to 77 and 45%, respectively. The high negative correlation (r = -0.90; p < 0.05) was observed between DA efflux and DOPAC content on aged, but not on adult rats (r = 0.11; p > 0.05). The suggestion concerning the aging--related changes of the interactions within striatal DA-ergic system is discussed.
Budygin
E A
EA
Kovalev
G I
GI
Gaĭntdinov
R R
RR
Kudrin
V S
VS
Voronina
T A
TA
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001481:Basal Metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013223:Statistics as Topic
D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid
Izuchenie vozrastnykh izmeneniĭ dofaminergicheskoĭ sistemy striatuma krys.