Changes in cerebrospinal fluid biotinidase activity in Staphylococcus aureus meningitis.
An early increase in activity of biotinidase in the cerebrospinal fluid (CSF) during the course of acute Staphylococcus aureus meningitis in a subject with subacute sclerosing panencephalitis (SSPE) is reported. A possible role of CSF biotinidase in the hydrolysis of specific opioid neuropeptides during acute inflammatory processes involving the CSF-central nervous system compartment is suggested.
De Felice
C
C
Endocrine and Metabolism Research Laboratory, National Children's Medical Research Center, National Children's Hospital, Tokyo, Japan.
Hayakawa
K
K
Nihei
K
K
Higuchi
S
S
Tanaka
T
T
Watanabe
T
T
Hibi
I
I
D000581:Amidohydrolases / Q000134:cerebrospinal fluid*; D043523:Biotinidase; D002648:Child; D005260:Female; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000150:complications / Q000201:enzymology; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000134:cerebrospinal fluid; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid* / Q000150:complications / Q000201:enzymology; D013344:Subacute Sclerosing Panencephalitis / Q000150:complications
D012794:Sialic Acids; D000581:Amidohydrolases; D043523:Biotinidase; D019158:N-Acetylneuraminic Acid