[Interconnection of interleukin-1 and glucocorticoid hormones in regulating the immune response].
IL-1 and hydrocortisone have an opposite and competitive effect on the lymphocyte proliferation in cell culture. In mice recombinant human IL-1 beta dose-dependently induces high level serum corticosterone. Injection of IL-1 beta or hydrocortisone led to a similar alterations in the thymus: reduction of cellularity and decrease in spontaneous thymocyte proliferation. On the other hand in the same doses IL-1 beta stimulates spleen cell proliferation. IL-2 production and enhances serum antibody titres and the number of antibody producing cells in spleen of mice immunized with T-dependent antigen.
Simbirtsev
A S
AS
Kotov
A Iu
AIu
Pigareva
N V
NV
Vorontsov
V I
VI
Goncharov
N P
NP
Ketlinskiĭ
S A
SA
D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D007375:Interleukin-1; D007376:Interleukin-2; D011994:Recombinant Proteins; D006854:Hydrocortisone
Vzaimosviaz' interleĭkina-1 i gliukokortikoidnykh gormonov v reguliatsii immunnogo otveta.