title: Functional relationships between genes of the Shaker gene complex of Drosophila.
abstract: Different mutations belonging to the HLI and HLII complementation groups of the haplolethal (HL) region of the Shaker complex (ShC) are described. The HLI complementation group includes viable (hdp), recessive lethals [l(1)1614], semidominant lethals [l(1)8384] and dominant lethals [l(1)5051, l(1)9916, l(1)13193], lack-of-function alleles that affect nervous system, cuticle and muscle development. The HLI complementation group encodes troponin I. HLII lack-of-function mutations [l(1)174 and l(1)4058] affect nervous system development. The semidominant lethal HLI mutation l(1)8384 shows differential complementation with other mutations in the ME and HL regions of ShC. Thus, heterozygous combinations of l(1)8384 with ME mutations l(1)162 and l(1)387 are poorly viable. The same phenomenon is observed for heterozygotes of l(1)8384 with HL mutations l(1)1199, l(1)2288 and l(1)3014. These specific interactions indicate the existence of functional relationships among the genetic elements of ShC. The implications for the understanding of the functional organization of ShC are discussed.
authors.affiliation: Instituto Cajal, CSIC, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: de la Pompa
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D006579:Heterozygote; D008297:Male; D009132:Muscles / Q000502:physiology; D009154:Mutation; D009424:Nervous System Physiological Phenomena; D010641:Phenotype