title: A case of pemphigus foliaceus after interferon alpha-2a therapy.
abstract: We present here a 63-year-old man with chronic hepatitis C who developed bullous lesions and anti-intercellular antibodies when he received interferon (IFN) alpha-2a, 9 MU subcutaneously, 3 times a week for 3 months. The direct immunofluorescence was consistent with pemphigus features. The indirect immunofluorescence showed negative before IFN treatment, but it became positive after 3 months. The immunoblot study showed no specific bands. This is the third report of the bullous lesions with anti-intercellular antibodies following IFN therapy.
authors.affiliation: Section of Dermatology, Kitasato Institute Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Niizeki
authors.forename: N
authors.initials: N
authors.lastname: Inamoto
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Tsuchimoto
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D006526:Hepatitis C / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011994:Recombinant Proteins
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins