Autoregulation of the human WT1 gene promoter.
The human Wilms tumour suppressor gene, WT1, encodes a zinc-finger protein which can function as a transcriptional activator or suppressor. This study reports the analysis of the human WT1 gene promoter, and demonstrates that high levels of WT1 expression lead to autosuppression of the WT1 promoter. Deletion analyses of the promoter region implicate sequences 5' and 3' of the transcriptional start site as being crucial in WT1 autosuppression. Loss or alteration of this function of WT1 may be important in tumourigenesis.
Malik
K T
KT
Department of Pathology & Microbiology, School of Medical Sciences, University of Bristol, UK.
Poirier
V
V
Ivins
S M
SM
Brown
K W
KW
D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017384:Sequence Deletion; D013489:Suppression, Genetic; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics
D004268:DNA-Binding Proteins; D025721:WT1 Proteins