title: Once daily antibiotic regimen in paediatric oncology.
abstract: The feasibility and efficacy of a once daily antibiotic regimen were assessed in children with malignant tumours. Over a 44 month period, 296 febrile episodes were treated with a regimen of once daily ceftriaxone-amikacin (and teicoplanin or vancomycin if the patient had a central line). The treatment was successful in 272 (92%) episodes without modification of the antibiotic regimen, and only one patient died of uncontrolled sepsis. A once daily antibiotic regimen is therefore feasible and worthwhile in the treatment of febrile episodes in children with cancer.
authors.affiliation: Paediatric Department, Centre L. Bérard, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: C
authors.initials: C
authors.lastname: Fuhrmann
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: D
authors.initials: D
authors.lastname: Couillioud
authors.forename: V
authors.initials: V
authors.lastname: Artiges
authors.forename: C
authors.initials: C
authors.lastname: Charra
authors.forename: D
authors.initials: D
authors.lastname: Bouhour
authors.forename: M
authors.initials: M
authors.lastname: Brunat Mentigny
mesh_terms: D000293:Adolescent; D000328:Adult; D000583:Amikacin / Q000008:administration & dosage; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D002443:Ceftriaxone / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005240:Feasibility Studies; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000628:therapy*; D017334:Teicoplanin / Q000008:administration & dosage; D014640:Vancomycin / Q000008:administration & dosage
chemical_list: D017334:Teicoplanin; D014640:Vancomycin; D002443:Ceftriaxone; D000583:Amikacin