[Virus-associated hemophagocytic syndrome with interstitial pneumonia in adults and a review of literature in Japan].
A 21-year-old man was admitted with fever, jaundice, abdominal pain and general fatigue. Other clinical manifestations revealed liver dysfunction, hepatosplenomegaly, pancytopenia and disseminated intravascular coagulation. Anti-EB virus (EA-DR-IgG) was initially elevated on admission and was decreased after that, furthermore anti EBNA was elevated in the late period of his clinical course, which indicated primary infection or secondary alteration of EBV immunity. Bone marrow examination revealed hemophagocytosis by mature histiocytes. Therefore, he was diagnosed as Virus-associated hemophagocytic syndrome (VAHS). An arterial blood gas analysis on admission showed hypoxemia and findings of interstitial pneumonia (IP) were distinctly observed on chest CT scan. Steroid therapy was then initiated and the patient responded very well. The clinical findings and laboratory data including IP, were improved. The 20 adult cases of VAHS in Japan were clinically studied and a review of the complication of VAHS with IP was also made.
Takayanagi
N
N
Department of Hematology, Japanese Red Cross Asahikawa Hospital.
Koda
K
K
Hirayama
Y
Y
Matsumoto
S
S
Ezoe
A
A
Nakazawa
O
O
Takeda
M
M
Tsuji
A
A
D000328:Adult; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D014412:Tumor Virus Infections / Q000150:complications*