TxA2-PGI2-PGF2 alfa responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension.
In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF1alfa ratio and, with the exception of response to prazosin, enhanced PGF2alfa excretion. Role of direct biochemical actions by the drugs in these responses was excluded by in vitro experiments with kidney slices from rats. The clinical and in vitro experimental findings suggested a mediator role of sympathetic activation but not that of the increased renin release in the urinary eicosanoid responses. Significant correlation was observed between the changes in reabsorbed amounts of sodium and excreted amounts of TxB2 and PGF2alfa. The results suggest that the reactivity of pressure type prostanoids in the kidney could be considered as part of a more complex renal counteraction to BP decrease.
Székács
B
B
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Juhász
I
I
Gachályi
B
B
Fehér
J
J
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D015237:Dinoprost / Q000378:metabolism / Q000652:urine; D011464:Epoprostenol / Q000378:metabolism / Q000652:urine; D005260:Female; D005711:Gallopamil / Q000494:pharmacology; D005919:Glomerular Filtration Rate; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013928:Thromboxane A2 / Q000378:metabolism* / Q000652:urine; D014665:Vasodilator Agents / Q000494:pharmacology*; D014690:Venous Pressure / Q000187:drug effects
D011453:Prostaglandins; D014665:Vasodilator Agents; D006830:Hydralazine; D005711:Gallopamil; D013928:Thromboxane A2; D012964:Sodium; D015237:Dinoprost; D011464:Epoprostenol; D011224:Prazosin