Physical mapping of Xq24-25 around loci closely linked to the X-linked lymphoproliferative syndrome locus: an overlapping YAC map and linkage between DXS12, DXS42, and DXS37.
We have localized several markers in the Xq24-25 region containing DXS12, DXS42 and DXS37 which are closely linked to the X-linked lymphoproliferative syndrome (XLP) locus. A 850-kb restriction map has been established by mapping overlapping YACs and showed that DXS12 and DXS42 are physically linked within about 50 kb. DXS37 is separated from these two loci at a maximum distance of 3,700 kb. Several new probes have been generated which will contribute to further physical mapping of this region.
Wang
Q
Q
International Agency for Research on Cancer, Lyon, France.
Ishikawa-Brush
Y
Y
Monaco
A P
AP
Nelson
D L
DL
Caskey
C T
CT
Pauly
S P
SP
Lenoir
G M
GM
Sylla
B S
BS
D016386:Chromosome Walking; D018244:Chromosomes, Artificial, Yeast; D015342:DNA Probes; D016521:Electrophoresis, Gel, Pulsed-Field; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000235:genetics*; D015183:Restriction Mapping; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers