title: Effect of a calcium carbonate-based toothpaste with 0.3% triclosan on pH changes in dental plaque in vivo.
abstract: The effects of a calcium carbonate-based toothpaste with added 0.3% triclosan on the pH of human dental plaque after a cariogenic challenge with 10% sucrose solution was investigated against a calcium carbonate-based toothpaste without triclosan and an alumina-based toothpaste. A silica-based toothpaste served as a control. Twenty adult volunteers were included in this study. The results showed that the plaque pH drop and the area under the curve for both calcium carbonate-based toothpastes, with and without 0.3% triclosan, were significantly less as compared with the alumina-based toothpaste, with both parameters being least for the toothpaste with added 0.3% triclosan. Calcium carbonate has been shown in previous studies to have a buffering effect on the plaque pH after an acidogenic challenge. The addition of 0.3% triclosan to the calcium carbonate-based toothpaste seemed to enhance this effect.
authors.affiliation: Division of Child Dental Health, Leeds Dental Institute, University of Leeds, UK.
authors.forename: J
authors.initials: J
authors.lastname: Tahmassebi
authors.forename: M S
authors.initials: MS
authors.lastname: Duggal
authors.forename: M E
authors.initials: ME
authors.lastname: Curzon
mesh_terms: D000293:Adolescent; D000328:Adult; D000537:Aluminum Oxide / Q000494:pharmacology / Q000627:therapeutic use; D000704:Analysis of Variance; D002119:Calcium Carbonate / Q000494:pharmacology* / Q000627:therapeutic use; D003773:Dental Plaque / Q000737:chemistry* / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D010710:Phosphates / Q000627:therapeutic use; D012822:Silicon Dioxide / Q000494:pharmacology / Q000627:therapeutic use; D013395:Sucrose / Q000378:metabolism; D014100:Toothpastes / Q000494:pharmacology* / Q000627:therapeutic use; D014260:Triclosan / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; D014260:Triclosan; D013395:Sucrose; D012822:Silicon Dioxide; D002119:Calcium Carbonate; D000537:Aluminum Oxide; D005459:Fluorides