title: Acute herpes hepatitis in pregnancy.
abstract: A 36 year old primigravid woman presented with a "flu-like" illness and premature labour, followed by severe pneumonitis and hepatitis in the late second trimester of pregnancy. Progressive deterioration obliged an elective delivery of twins, stillborn at 25 weeks of gestation. Herpes virus isolated from one placenta, but not from any fetal tissue, was the only indication of a systemic herpes simplex infection in which there were no mucocutaneous lesions seen before or during the illness. There was no history of herpes simplex infection and antibody studies were not helpful initially for a diagnosis that was confirmed in retrospect. Double staining for viral DNA and antigen showed that the virus was present in host monocytes.
authors.affiliation: Department of Clinical Virology, John Radcliffe Hospital, Headington, Oxford.
authors.forename: C G
authors.initials: CG
authors.lastname: Fink
authors.forename: S J
authors.initials: SJ
authors.lastname: Read
authors.forename: J
authors.initials: J
authors.lastname: Hopkin
authors.forename: T
authors.initials: T
authors.lastname: Peto
authors.forename: S
authors.initials: S
authors.lastname: Gould
authors.forename: J B
authors.initials: JB
authors.lastname: Kurtz
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006561:Herpes Simplex / Q000150:complications*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology*; D018139:Simplexvirus / Q000302:isolation & purification
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral