title: Trichothiodystrophic hair reveals an abnormal pattern of viscoelastic parameters.
abstract: Separate analysis and quantitative determination of the viscous and elastic parameters of hair performed in 5 patients with trichothiodystrophy and in 20 sex- and age-matched control subjects revealed an abnormal pattern of the mechanical behavior of trichothiodystrophic hair. The change of the viscous parameter is probably associated with the profound alterations in the high-sulfur proteins of the interfilamentary matrix; the changes in the elastic parameters may be related to the reduced stability of the irregularly arranged microfibrils of trichothiodystrophic hair caused by the marked reduction of the disulfide cross-links.
authors.affiliation: Department of Dermatology, University of Patras, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Tsambaos
authors.forename: G
authors.initials: G
authors.lastname: Nikiforidis
authors.forename: C
authors.initials: C
authors.lastname: Balas
authors.forename: S
authors.initials: S
authors.lastname: Marinoni
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003432:Cross-Linking Reagents; D004220:Disulfides / Q000378:metabolism; D004548:Elasticity; D005260:Female; D006197:Hair / Q000473:pathology* / Q000503:physiopathology; D006201:Hair Diseases / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D014783:Viscosity
chemical_list: D003432:Cross-Linking Reagents; D004220:Disulfides