Incidence of circulating cells positive for GpIb and GpIIIa in infants with Down's syndrome.
Blood samples from 43 infants with Down's syndrome and from 67 with a normal karyotype were screened for the presence of cells positive for platelet glycoproteins GpIb and GpIIIa. There was 1 case of fatal leukaemia and 1 case of transient leukaemia among the Down's syndrome patients, both cases had increased numbers of circulating blood cells positive for platelet glycoprotein markers. These cells were present in small numbers in both the Down's and control groups, especially among stillbirths, and there was no difference in the numbers of such cells found in Down's syndrome patients in comparison with the controls.
Fisher
A M
AM
Wessex Regional Genetics Laboratory, Salisbury District Hospital, U.K.
Cockwell
A E
AE
Jacobs
P A
PA
Parry
H F
HF
D001853:Bone Marrow / Q000737:chemistry; D004314:Down Syndrome / Q000097:blood*; D006412:Hematopoietic Stem Cells / Q000737:chemistry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008533:Megakaryocytes / Q000737:chemistry; D010980:Platelet Membrane Glycoproteins / Q000097:blood*
D010980:Platelet Membrane Glycoproteins