title: The significance of eccentric foci of hyperpigmentation ('small dark dots') within melanocytic nevi. Analysis of 59 cases.
abstract: METHODS
  Fifty-nine melanocytic nevi with eccentric foci of hyperpigmentation ("small dark dots") that measured primarily 1 to 2 mm in diameter were prospectively examined to determine the histologic correlates of the dark dots.
  
  
  RESULTS
  Forty-one (69%) of the dark dots were due to increased melanin in epidermal melanocytes and/or keratinocytes, usually accompanied by melanophages; of these 41, six (15%) were associated with slight or moderate melanocytic nuclear atypia. Fifteen (25%) of the dark dots were due to increased dermal pigment that was either superficial or deep. Three (5%) of the dark dots were due to melanoma arising within a nevus.
  
  
  CONCLUSIONS
  A small percentage of "small dark dots" within melanocytic nevi are due to melanoma. Biopsy specimens of nevi with small dark dots should be sectioned to ensure histologic examination of this focus of hyperpigmentation.
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Conn.
authors.forename: J L
authors.initials: JL
authors.lastname: Bolognia
authors.forename: A
authors.initials: A
authors.lastname: Lin
authors.forename: P E
authors.initials: PE
authors.lastname: Shapiro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D004416:Dysplastic Nevus Syndrome / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D017495:Hyperpigmentation / Q000473:pathology*; D015603:Keratinocytes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008543:Melanins; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000473:pathology; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology*; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D008543:Melanins