title: SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin.
abstract: SB-202742 [1], an anacardic acid derivative possessing beta-lactamase inhibitory activity, has been isolated from a hexane extract of the plant, Spondias mombin. Its isolation, structure determination, and biological activity are reported herein.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Coates
authors.forename: M L
authors.initials: ML
authors.lastname: Gilpin
authors.forename: M N
authors.initials: MN
authors.lastname: Gwynn
authors.forename: D E
authors.initials: DE
authors.lastname: Lewis
authors.forename: P H
authors.initials: PH
authors.lastname: Milner
authors.forename: S R
authors.initials: SR
authors.lastname: Spear
authors.forename: J W
authors.initials: JW
authors.lastname: Tyler
mesh_terms: D048729:Anacardic Acids; D002851:Chromatography, High Pressure Liquid; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010936:Plant Extracts / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D012459:Salicylates / Q000302:isolation & purification* / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors
chemical_list: D048729:Anacardic Acids; D010936:Plant Extracts; D012459:Salicylates; D065093:beta-Lactamase Inhibitors; C088926:SB 202742