title: Ribosomal heterogeneity from chromatin diminution in Ascaris lumbricoides.
abstract: The genome of Ascaris lumbricoides encodes both germline- and soma-specific proteins homologous to the eukaryotic small ribosomal protein (Rp) S19. The two Ascaris homologs differ by 24 amino acid substitutions and are both components of the small ribosomal subunits. In oocytes, the germline RpS19 homolog (RpS19G) predominates. During chromatin diminution, however, the gene is eliminated from all presomatic cells, and RpS19G is replaced by the product of the somatic gene (RpS19S). Chromatin diminution in A. lumbricoides causes a change in the protein composition of ribosomes during development and represents an alternative means of gene regulation.
authors.affiliation: Institute of Zoology, University of Fribourg, Pérolles, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Etter
authors.forename: V
authors.initials: V
authors.lastname: Bernard
authors.forename: M
authors.initials: M
authors.lastname: Kenzelmann
authors.forename: H
authors.initials: H
authors.lastname: Tobler
authors.forename: F
authors.initials: F
authors.lastname: Müller
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017164:Ascaris lumbricoides / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D005075:Biological Evolution; D002843:Chromatin / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D017238:Genes, Helminth; D015801:Helminth Proteins; D006801:Humans; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism; D014176:Protein Biosynthesis; D011993:Recombinant Fusion Proteins / Q000737:chemistry; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D012270:Ribosomes / Q000737:chemistry*; D016415:Sequence Alignment
chemical_list: D002843:Chromatin; D015801:Helminth Proteins; D011993:Recombinant Fusion Proteins; D012269:Ribosomal Proteins; C067677:ALEP-1 protein, Ascaris lumbricoides