Fungal metabolites. XVI. Structures of new peptaibols, trichokindins I-VII, from the fungus Trichoderma harzianum.
New peptaibols, trichokindins I-VII, have been isolated from the fungus Trichoderma harzianum. Their structures were characterized by spectrometric methods. Trichokindins, which are 18-residue peptides containing one to three isovaline residues, were found to induce Ca(2+)-dependent catecholamine secretion from bovine adrenal medullary chromaffin cells.
Iida
A
A
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Sanekata
M
M
Fujita
T
T
Tanaka
H
H
Enoki
A
A
Fuse
G
G
Kanai
M
M
Rudewicz
P J
PJ
Tachikawa
E
E
D000313:Adrenal Medulla / Q000166:cytology* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism; D002417:Cattle; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014242:Trichoderma / Q000378:metabolism*
D002395:Catecholamines; D010455:Peptides; D002118:Calcium