title: Some toxicity thresholds for the clinical effects of common tiger snake (Notechis scutatus) envenomation in the dog.
abstract: Common tiger snake (Notechis scutatus) venom was administered experimentally to dogs at doses from 0.25 lethal dose (LD) to 20 LD. Haemolysis and increased creatine kinase values occurred rapidly after injection of sublethal (subparalytic) doses, but the clotting time of blood was extended and blood became incoagulable only when dogs were dosed with 10 LD or more of venom. Haemolysis, although of a low threshold of toxicity, was not severe and should not greatly affect the lethality of the venom. Coagulopathy is a sign that the dog has been lethally envenomed and will need to be given antivenom if skeletal muscle paralysis is to be overcome.
authors.forename: P F
authors.initials: PF
authors.lastname: Lewis
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D003402:Creatine Kinase / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced* / Q000652:urine; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004546:Elapid Venoms / Q000633:toxicity*; D017815:Elapidae; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D008297:Male; D012909:Snake Bites / Q000097:blood / Q000652:urine / Q000662:veterinary*
chemical_list: D004546:Elapid Venoms; D006454:Hemoglobins; D003402:Creatine Kinase