[HLA class I and II antigens and diffuse toxic goiter].
The incidence rate of HLA class I and II antigens has been studied in 168 and 82 patients with diffuse toxic goiter, respectively. Positive association is found for HLA antigens A2, A3, A28, B8, B15, B17, Cw4, DR5; negative one with antigens A24, Bw4, Bw6, Cw1, Cw2, Cw3, Cw5, DR9. Prevalence of antigens B15, B17, Cw4, DR5 is associated with thyrotoxicosis severity, A2 with recurrent toxic goiter. Antigen B8 plays the role of an immunogenetic marker of endocrine ophthalmopathy.
Kalinin
A P
AP
Kamynina
T S
TS
Zaretskaia
Iu M
IuM
Abramov
V Iu
VIu
Klinova
E G
EG
Karachintsev
V I
VI
D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D016009:Chi-Square Distribution; D002908:Chronic Disease; D005260:Female; D006111:Graves Disease / Q000453:epidemiology / Q000276:immunology*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D000949:Histocompatibility Antigens Class II / Q000097:blood*; D006801:Humans; D015994:Incidence; D008297:Male; D009031:Moscow / Q000453:epidemiology; D013971:Thyrotoxicosis / Q000453:epidemiology / Q000276:immunology
D015415:Biomarkers; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II
Antigeny HLA I i II klassa i diffuznyĭ toksicheskiĭ zob.