Clinical and histological features of 'mechanic's hands' in a patient with antibodies to Jo-1--a case report.
The clinical and histological features of 'mechanic's hands' are described in a patient with polymyositis characterized serologically by antibodies to histidyl tRNA synthetase (Jo-1). Although described in the past in association with polymyositis, these distinctive cutaneous lesions have only recently been associated with the 'anti-synthetase syndrome'. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clinical and serological features not only have prognostic significance, but also may provide insights into mechanisms of disease.
Mitra
D
D
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, UK.
Lovell
C L
CL
Macleod
T I
TI
Tan
R S
RS
Maddison
P J
PJ
D000368:Aged; D000906:Antibodies / Q000032:analysis*; D005260:Female; D006229:Hand Dermatoses / Q000276:immunology / Q000473:pathology*; D006643:Histidine-tRNA Ligase / Q000276:immunology*; D006801:Humans; D007642:Keratosis / Q000276:immunology / Q000473:pathology; D017285:Polymyositis / Q000276:immunology / Q000473:pathology*
D000906:Antibodies; D006643:Histidine-tRNA Ligase