title: [Effectiveness of the new quinolones, ciprofloxacin and pefloxacin in experimental plague].
abstract: Efficacy of ciprofloxacin and pefloxacin in plague infection was studies on albino mice by comparison with that of nalidixic acid. The mice were contaminated subcutaneously. The treatment with the drugs was started 6 or 24 hours after the contamination. The MICs of ciprofloxacin, pefloxacin and nalidixic acid were 0.01 to 0.02, 0.15 and 1.25 to 2.5 micrograms/ml respectively. By the ED50 ciprofloxacin proved to be the most efficient. Pefloxacin was 6 times less efficient and nalidixic acid was 100 times less efficient. The quinolones were shown to be highly efficient when administered at 48-hour intervals.
authors.forename: I V
authors.initials: IV
authors.lastname: Kasatkina
authors.forename: A I
authors.initials: AI
authors.lastname: Sherbaniuk
authors.forename: L N
authors.initials: LN
authors.lastname: Makarovskaia
authors.forename: E N
authors.initials: EN
authors.lastname: Padeĭskaia
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D051379:Mice; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000627:therapeutic use*; D015366:Pefloxacin / Q000627:therapeutic use*; D010930:Plague / Q000188:drug therapy*
chemical_list: D015366:Pefloxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin
vernacular_title: Izuchenie éffektivenosti novykh khinolonov--tsiprofloksatsina i pefloksatsina pri éksperimental'noĭ chume.