title: Plasma adrenaline concentration is lower in post-obese than in never-obese women in the basal state, in response to sham-feeding and after food intake.
abstract: 1. Plasma pancreatic polypeptide, plasma catecholamine, blood glucose, plasma insulin and plasma peptide YY concentrations were studied to assess differences between eight formerly obese and eight never-obese control women during 25 min of sham-feeding (with the sight and smell of an English breakfast) and for 5 h after they had ingested the meal (3514 kJ, 50% fat, 35% carbohydrate). The post-obese women had maintained their normal body weight for at least 3 months before the study. 2. The plasma noradrenaline concentration was not different between the groups either during fasting (post-obese women 0.08 +/- 0.01 ng/ml versus control women 0.10 +/- 0.01 ng/ml) or in the significant postprandial increase (P < 0.001). The plasma adrenaline concentration increased significantly during sham-feeding in the control group from 0.024 +/- 0.004 ng/ml to 0.033 +/- 0.004 ng/ml (P = 0.02) in contrast with the post-obese women, who had significantly lower plasma concentrations of adrenaline in the fasting state (post-obese 0.016 +/- 0.003 ng/ml versus control women 0.024 +/- 0.004 ng/ml, P = 0.003), during sham-feeding (post-obese women 0.018 +/- 0.002 ng/ml versus control women 0.033 +/- 0.004 ng/ml, P = 0.003) and in the postprandial increase (P = 0.003). The maximal postprandial response concentrations recorded 5 h after the meal were 0.025 +/- 0.003 ng/ml in post-obese women and 0.035 +/- 0.004 ng/ml in control subjects (P = 0.04). There were no significant differences in plasma pancreatic polypeptide, plasma peptide YY, plasma insulin, or blood glucose concentrations between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Internal Medicine and Endocrinology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Bryde Andersen
authors.forename: A
authors.initials: A
authors.lastname: Raben
authors.forename: A
authors.initials: A
authors.lastname: Astrup
authors.forename: N J
authors.initials: NJ
authors.lastname: Christensen
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002149:Energy Intake / Q000502:physiology*; D004837:Epinephrine / Q000097:blood*; D005215:Fasting / Q000502:physiology; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D009765:Obesity / Q000097:blood*; D010191:Pancreatic Polypeptide / Q000097:blood; D019894:Peptide YY; D010455:Peptides / Q000097:blood; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D007328:Insulin; D010455:Peptides; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D009638:Norepinephrine; D004837:Epinephrine