Benextramine, an NPY antagonist, improves sexual behavior in male rats.
In adult, sexually-experienced male rats, the NPY-antagonist benextramine--at the doses of 5 and 10 mg/kg i.p. and of 50 micrograms/rat i.c.v.--significantly and specifically improved several parameters of copulatory activity. These data may further support the idea that NPY plays a role in the complex regulation of male sexual function, seemingly at the brain level.
Poggioli
R
R
Institute of Pharmacology, University of Modena, Italy.
Benelli
A
A
Arletti
R
R
Menozzi
B
B
Bertolini
A
A
D000818:Animals; D003538:Cystamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008297:Male; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D009478:Neuropeptide Y; C029998:benextramine; D003538:Cystamine