Heparin cofactor II in diabetic patients.
Levels of heparin cofactor II (HCII) activity and antigen and electrophoretic pattern were studied both in normal subjects and in type I diabetic patients with high and normal levels of glycosylated haemoglobin. There was a significant reduction in HCII activity (83 +/- 7%) in patients with high levels of glycosylated haemoglobin compared with controls (95 +/- 17%; P < 0.001). However, plasma HCII antigen levels were not decreased in these patients.
Duboscq
C
C
Department of Biological Chemistry, School of Exact and Natural Sciences, Buenos Aires University, Argentina.
Quintana
I
I
Barros
J
J
Kordich
L
L
D000328:Adult; D000941:Antigens / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D015844:Heparin Cofactor II / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D000941:Antigens; D006442:Glycated Hemoglobin; D015844:Heparin Cofactor II