title: Genetic fine localization of the arrestin (S-antigen) gene 4 cM distal from D2S172.
abstract: Arrestin is a component of the light transduction cascade that takes place in the outer segment of retinal rods. In situ hybridization and linkage analysis have localized the arrestin gene to a region of 50 cM between CRYG alpha and D2S23/D2S55 on chromosome 2q24-37. We have performed pairwise and multipoint linkage analysis between arrestin and four highly polymorphic markers from this region. The results indicate tight linkage between the gene and the microsatellite D2S172 (Zmax = 9.25 at theta = 0.038). This fine localization of the gene should provide a useful tool for cosegregation analyses involving the arrestin gene.
authors.affiliation: Unitat de Genètica Molecular, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Valverde
authors.forename: M
authors.initials: M
authors.lastname: Bayés
authors.forename: I
authors.initials: I
authors.lastname: Martínez
authors.forename: D
authors.initials: D
authors.lastname: Grinberg
authors.forename: L
authors.initials: L
authors.lastname: Vilageliu
authors.forename: S
authors.initials: S
authors.lastname: Balcells
authors.forename: R
authors.initials: R
authors.lastname: Gonzàlez-Duarte
authors.forename: M
authors.initials: M
authors.lastname: Baiget
mesh_terms: D000941:Antigens / Q000235:genetics*; D019393:Arrestin; D001483:Base Sequence; D002874:Chromosome Mapping; D005136:Eye Proteins / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins