title: Pleural effusion associated with chronic dantrolene administration.
abstract: OBJECTIVE
  To report a case of pleural effusion associated with chronic dantrolene administration.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Private, university-affiliated, teaching hospital.
  
  
  RESULTS
  Twelve years after the initiation of low-dose dantrolene therapy for chronic spasticity, a 35-year-old man developed a pleural effusion with pleural and peripheral eosinophilia. This reaction gradually resolved over several months after discontinuation of the dantrolene therapy.
  
  
  CONCLUSIONS
  In patients treated with chronic dantrolene therapy, the presence of pleural effusions should raise the suspicion of dantrolene-induced disease. Withdrawal of dantrolene therapy has generally been associated with an alleviation of signs and symptoms within several months.
authors.affiliation: Saint Louis College of Pharmacy.
authors.forename: J M
authors.initials: JM
authors.lastname: Mahoney
authors.forename: M D
authors.initials: MD
authors.lastname: Bachtel
mesh_terms: D000328:Adult; D003620:Dantrolene / Q000008:administration & dosage / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010996:Pleural Effusion / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D003620:Dantrolene