[Plasma erythropoietic activity in healthy children and in children with iron-deficiency anemia].
The level of plasma erythropoietic activity was determined in healthy and iron deficiency anemia children by bioassay in vitro. The erythropoietic activity in healthy children was 13.6 +/- 2.9 (5.0-24.8) mU/ml and the lowest activity was in two month (6.3 +/- 0.7) and three month (6.9 +/- 1.4) mU/ml healthy children. The erythropoietic activity was increased from 40.5 to 715.0 mU/ml in iron deficiency anemia children and its level distinctly depends on anemia stage and iron deficiency. From this study we suggest, that erythropoietin is produced in response of anemia. The results also demonstrate the necessity of erythropoietin treatment in iron deficiency anemia in early infants.
Soboleva
M K
MK
Manakova
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TE
D000367:Age Factors; D000747:Anemia, Hypochromic / Q000097:blood*; D000818:Animals; D001681:Biological Assay; D002478:Cells, Cultured; D002675:Child, Preschool; D004920:Erythropoiesis / Q000502:physiology*; D006801:Humans; D007223:Infant; D051379:Mice; D008807:Mice, Inbred BALB C; D012016:Reference Values
Eritropoéticheskaia aktivnost' plazmy u zdorovykh i bol'nykh zhelezodefitsitnoĭ anemieĭ deteĭ.