[The effect of a natural complex of cytokines on oxygen-dependent function of rat vaginal phagocytes].
Our investigation consisted in 10-days treatment of vaginal mucous membrane wounds in white not inbred rats by introduction of natural cytokines complex into the vagina. At the same time the dynamics of vaginal phagocytes oxygen-depended function change was studied. We have ascertained the activating influence of the cytokines complex on the phagocytes chemiluminescence (CL) that found expression in 2.5-7 times fold augmentation of the CL intensity in comparison with control level (an equal portion of Medium--199 was introduced in the vagina of control-group rats). Having ended the application of the cytokines complex we have observed a rather fast normalization of the cells' activity (by the 15-17 days), consequently the cytokines did not have a distant effect on the oxygen-depended phagocytes function. We consider the activation of the phagocytes in wound as well as the bactericidal effect of the oxygen free radicals generated by the phagocytes as positive result.
Rubleva
K I
KI
Mynbaev
O A
OA
Sukhikh
G T
GT
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D005260:Female; D005609:Free Radicals; D008163:Luminescent Measurements; D008262:Macrophage Activation; D010100:Oxygen / Q000378:metabolism*; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D014621:Vagina / Q000276:immunology / Q000293:injuries* / Q000378:metabolism
D016207:Cytokines; D005609:Free Radicals; D010100:Oxygen
Vliianie estestvennogo kompleksa tsitokinov na kislorod-zavisimuiu funktsiiu fagotsitov vlagalishcha krys.