Early blastic transformation of a myeloproliferative disorder with t(8;21) and progressive aberrations of chromosome 8.
We describe a case of a patient affected by a chronic myeloproliferative disorder with t(8;21)(q22;q22) and trisomy 8 at diagnosis. At the time of blastic metamorphosis, 2 months later, trisomy 8 metaphases were significantly reduced, while a predominance of t(8;21) was present. Finally, in the phase of leukemic regrowth following chemotherapy administration, monosomy 8 associated with der(21)t(8;21) was the predominant cytogenetic abnormality.
Fasanaro
A
A
Division of Hematology, Cardarelli General Hospital, Naples, Italy.
Paone
G
G
Silvestri
I
I
Marottoli
V
V
Cimino
R
R
Ferrara
F
F
D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009006:Monosomy; D014178:Translocation, Genetic; D014314:Trisomy