title: The effect of long-term exposure to anthio on serum esterases and ruminal microorganisms of male calves.
abstract: The effect of long-term exposure to the organophosphate insecticide Anthio on serum esterases and ruminal microorganisms of male calves was investigated. The daily oral administration of 3, 6 or 12 mg Anthio/kg/d for 90 d caused significant inhibition of serum cholinesterase (10-28%) and carboxylesterase (12-33%) in male calves. Toxic signs characteristic of anticholinesterase poisoning were observed during 25-70 d of exposure to 6 and 12 mg Anthio/kg. The dose of 12 mg Anthio/kg was lethal to 1/5 calves. Total protozoal population was decreased significantly (15-27%) following 6 and 12 mg Anthio/kg, whereas reduction in total bacterial population (18%) was only significant at 12 mg Anthio/kg.
authors.affiliation: Department of Pharmacology, Bangladesh Agricultural University, Mymensingh.
authors.forename: M D
authors.initials: MD
authors.lastname: Awal
authors.forename: A K
authors.initials: AK
authors.lastname: Saifuddin
mesh_terms: D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000097:blood* / Q000187:drug effects; D002417:Cattle / Q000097:blood* / Q000382:microbiology* / Q000469:parasitology; D002802:Cholinesterases / Q000097:blood* / Q000187:drug effects; D056890:Eukaryota / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D012417:Rumen / Q000187:drug effects / Q000382:microbiology* / Q000469:parasitology*
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; C067599:formothion; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D002802:Cholinesterases