Insulin and hypertension: are they related?
It has been postulated that insulin resistance and the concomitant compensatory hyperinsulinemia contribute to the pathogenesis of hypertension; possible by stimulating the sympathetic nervous system, promoting renal sodium reabsorption, modulating cation transport, and/or stimulating vascular smooth muscle hypertrophy. The purpose of this article is to present a comprehensive up-to-date review of the literature and critically examine the insulin resistance-hyperinsulinemia-hypertension hypothesis.
Meehan
W P
WP
Department of Medicine, University of Southern California Medical School, Los Angeles 90038.
Darwin
C H
CH
Maalouf
N B
NB
Buchanan
T A
TA
Saad
M F
MF
D000818:Animals; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D006973:Hypertension / Q000209:etiology*; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000150:complications