title: Serum levels of insulin-like growth factor in subjects with osteoarthritis of the knee. Data from the Baltimore Longitudinal Study of Aging.
abstract: OBJECTIVE
  To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee.
  
  
  METHODS
  Serum IGF-1 levels were compared in 162 male and 101 female subjects age > or = 20 stratified by presence of radiographic changes of OA of the knee.
  
  
  RESULTS
  Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant.
  
  
  CONCLUSIONS
  These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.
authors.affiliation: University of Maryland School of Medicine, Baltimore.
authors.forename: M C
authors.initials: MC
authors.lastname: Hochberg
authors.forename: M
authors.initials: M
authors.lastname: Lethbridge-Cejku
authors.forename: W W
authors.initials: WW
authors.lastname: Scott
authors.forename: R
authors.initials: R
authors.lastname: Reichle
authors.forename: C C
authors.initials: CC
authors.lastname: Plato
authors.forename: J D
authors.initials: JD
authors.lastname: Tobin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007719:Knee Joint / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood* / Q000000981:diagnostic imaging; D011859:Radiography
chemical_list: D007334:Insulin-Like Growth Factor I