Lytic bone lesions suspected for metastasis: ultrasonically guided fine-needle aspiration biopsy.
Ultrasonically guided fine-needle aspiration biopsy (US-FNAB) was performed in 30 patients with a lytic bone lesions suspected for metastasis detected by conventional radiological examinations. The patients were selected for US-FNAB on the basis of the ability of the ultrasound examination to clearly visualize the lesion. The cytological diagnosis was confirmed at surgery in 3 cases, and at clinical and radiological follow-up after more than 6 months in the remaining cases. The lesions were located mostly in the thoracic skeleton (ribs and sternum) and pelvic bone. We diagnosed malignancy in 26 cases and benign lesions in 2 cases. An inadequate sample was obtained in 1 case, and 1 case yielded a false-negative result. According to these results, we obtained a sensitivity of 93%. We conclude that ultrasonically guided fine-needle aspiration biopsy is a useful technique to obtain a pathological diagnosis in cases of lytic bone lesions that can be visualized with this imaging technique.
Civardi
G
G
First Department of Medicine, City Hospital, Piacenza, Italy.
Livraghi
T
T
Colombo
P
P
Fornari
F
F
Cavanna
L
L
Buscarini
L
L
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary*; D001862:Bone Resorption / Q000000981:diagnostic imaging* / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology; D003949:Diagnostic Techniques, Surgical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000473:pathology; D012272:Ribs / Q000000981:diagnostic imaging / Q000473:pathology; D012680:Sensitivity and Specificity; D013249:Sternum / Q000000981:diagnostic imaging / Q000473:pathology; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D018084:Ultrasonography, Interventional