Mortality in gerbils with repetitive ischemia: CGSGS-19755/hypothermia therapy.
Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was offered by both CGS-19755 and combination CGS-19755-hypothermia treatments. Current practices of sacrificing repetitive ischemia subjects shortly postischemia may lead to an underestimation of the effects of ischemia and/or an overestimation of the protective effects of experimental treatments.
McCrea
S
S
Department of Psychology, Faculty of Medicine, University of Saskatchewan, Saskatoon, Canada.
Shuaib
A
A
Wishart
T
T
Ijaz
S
S
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D016923:Cell Death / Q000187:drug effects; D003131:Combined Modality Therapy; D005849:Gerbillinae; D007036:Hypothermia, Induced; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D009474:Neurons / Q000187:drug effects; D010875:Pipecolic Acids / Q000627:therapeutic use*; D016548:Prosencephalon / Q000473:pathology; D012008:Recurrence
D010875:Pipecolic Acids; C053672:selfotel; D016202:N-Methylaspartate