Lambert-Eaton myasthenic syndrome in small cell lung cancer: nursing implications.
OBJECTIVE
To describe the pathophysiology and nursing care of patients with Lambert-Eaton myasthenic syndrome (LEMS), a little-known paraneoplastic syndrome.


METHODS
Published articles, books and book chapters, and clinical trial experience.


RESULTS
LEMS most commonly is associated with small cell lung cancer. Clinical presentation is characterized by weakness of the proximal muscles of the pelvis, thighs, shoulders, and arms and a weakening or absence of deep tendon reflexes. These symptoms are the manifestations of an abnormality at the neuromuscular junction and may precede the diagnosis of lung cancer.


CONCLUSIONS
The oncology nurse knowledgeable about the pathophysiology, clinical features, diagnostic evidence, and treatment of LEMS is better able to care for and teach patients with this disorder.


CONCLUSIONS
Nurses must assist patients in adjusting not only to a diagnosis of cancer and its treatment effects but also to the symptoms of LEMS, including impaired mobility, self-care deficits, and fatigue.
Struthers
C S
CS
Glenbrook Hospital, Glenview, IL.
D000328:Adult; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000209:etiology* / Q000451:nursing / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000451:nursing / Q000503:physiopathology*