title: Giant cell tumor of the larynx. Case report and review of the literature.
abstract: Giant cell tumor of bone is rare in the osteocartilaginous tissues of the larynx. We describe a 23-year-old man with a 6-month history of progressive hoarseness and an enlarging neck mass. Computed tomography demonstrated a 4-cm mass with central cystic change arising in the right ala of the thyroid cartilage. A hemilaryngectomy was performed. Grossly, the lesion was expansile and circumscribed, but unencapsulated. On microscopic examination, numerous multinucleated giant cells were evenly dispersed within a cellular and vascular stroma. The findings were characteristic of giant cell tumor of bone. The patient has been disease free for 56 months. A review of the international literature yielded 11 cases. No lesion is known to have recurred after surgical excision, irradiation, or both. We present a clinicopathologic analysis of giant cell tumors involving the larynx and conclude that giant cell tumors are associated with a favorable clinical outcome.
authors.affiliation: Department of Pathology, Tulane University School of Medicine, New Orleans, LA.
authors.forename: P C
authors.initials: PC
authors.lastname: Martin
authors.forename: S A
authors.initials: SA
authors.lastname: Hoda
authors.forename: H T
authors.initials: HT
authors.lastname: Pigman
authors.forename: D R
authors.initials: DR
authors.lastname: Pulitzer
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male