[Antioxidative activity of drugs used in anticonvulsive therapy].
The influence of medicines used in anticonvulsive therapy: phenobarbital, diphenin, phenazepam and Na-valproate at ascorbate-(ASPOL) and NADP H-(PhPOL) depended lipid peroxidation (POL) in pattern systems (homogenates of rat's brain--HRB, lecithin liposomes-LL) has been studied. It has been established that this medicines do not influence at ASPOL in LL in concentration range of 10-10 M. Phenobarbital (10 M) and Na-valproate (10 M) inhibit ASPOL and PhPOL in HRB in 20-25%. Diphenin (10 M) and phenazepam' 10 M) inhibit both types of POL in HRB in 20-25%. Thus, tested medicines, being not the antioxidants themselves, influence at some components in POL regulating system in nerve tissue, inhibiting this process.
Nikushkin
E V
EV
Bordiukov
M M
MM
D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008954:Models, Biological; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D014635:Valproic Acid / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000975:Antioxidants; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital
Antiokislitel'naia aktivnost' preparatov, primeniaemykh v protivosudorozhnoĭ terapii.