title: Production of Apx toxins by field strains of Actinobacillus pleuropneumoniae and Actinobacillus suis.
abstract: The three Apx toxins of Actinobacillus pleuropneumoniae have potential value for use in vaccines and diagnostic tests which will be species specific instead of serotype specific, provided that the Apx toxins are species specific and all field strains produce these toxins. We examined 114 A. pleuropneumoniae field strains and found that they secreted either ApxI, ApxII, ApxI and ApxII, or ApxII and ApxIII and secreted no other cytolytic activities. However, proteins similar to ApxI and ApxII were also produced by Actinobacillus suis.
authors.affiliation: Department of Bacteriology, Central Veterinary Institute, Lelystad, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: Kamp
authors.forename: T M
authors.initials: TM
authors.lastname: Vermeulen
authors.forename: M A
authors.initials: MA
authors.lastname: Smits
authors.forename: J
authors.initials: J
authors.lastname: Haagsma
mesh_terms: D000188:Actinobacillus / Q000472:pathogenicity*; D016977:Actinobacillus pleuropneumoniae / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D001427:Bacterial Toxins / Q000032:analysis / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D006460:Hemolysin Proteins
chemical_list: C085361:ApxII toxin, bacteria; C079721:ApxIII toxin protein, Actinobacillus; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; C087744:ApxI toxin, Bacteria