title: Methotrexate in systemic lupus erythematosus.
abstract: OBJECTIVE
  Methotrexate (MTX) has been used successfully in the treatment of rheumatoid arthritis, psoriatic arthritis, polymyositis, and Reiter's syndrome. Our objective was to determine the effectiveness of MTX in the treatment of systemic lupus erythematosus (SLE).
  
  
  METHODS
  We reviewed retrospectively MTX therapy in 5 patients with SLE, 3 with renal disease and 2 with arthritis.
  
  
  RESULTS
  MTX therapy was well tolerated and effective in all 5 patients.
  
  
  CONCLUSIONS
  MTX appears to be both effective and well tolerated in patients with SLE.
authors.affiliation: Lupus Clinic, Wellesley Hospital, Toronto, ON, Canada.
authors.forename: B A
authors.initials: BA
authors.lastname: Walz LeBlanc
authors.forename: P
authors.initials: P
authors.lastname: Dagenais
authors.forename: M B
authors.initials: MB
authors.lastname: Urowitz
authors.forename: D D
authors.initials: DD
authors.lastname: Gladman
mesh_terms: D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D008181:Lupus Nephritis / Q000188:drug therapy / Q000209:etiology; D008727:Methotrexate / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D008727:Methotrexate