Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols.
The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicensis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.
Heltzel
C E
CE
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Gunatilaka
A A
AA
Kingston
D G
DG
Hofmann
G A
GA
Johnson
R K
RK
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D013261:Sterols