Adhesion molecules in the pathogenesis of rheumatoid arthritis.
The molecules on the cell surface that mediate inflammatory interactions between endothelial cells and leukocytes and of leukocytes with one another have been isolated and their fine structure elucidated. Early studies clearly indicated that the interactions mediated by these proteins are involved in the pathogenesis of rheumatoid arthritis. This article is a review of work published over the past year that has confirmed and expanded the role of adhesive proteins on vascular endothelium, leukocytes, and other synovial cells in the pathogenesis of rheumatoid arthritis. Moreover, the results of recent studies have suggested novel strategies for the development of agents for the treatment of rheumatoid arthritis.
Cronstein
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New York University Medical Center, Department of Medicine, NY 10016.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015815:Cell Adhesion Molecules