Linkage analysis between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene.
Using 23 multiplex pedigrees we tested for linkage between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene (DRD5). Assuming autosomal dominant inheritance and a maximum penetrance of 0.6, an overall lod score of -4.54 was derived at 0% recombination. For recessive transmission the summary lod score was -8.37 at 0% recombination. These data suggest that mutations of the D5 dopamine receptor gene are unlikely to be of major etiological importance in the pathogeneses of schizophrenia in the families studied. However, our study does not exclude the D5 dopamine receptor gene as a candidate gene for schizophrenia because some of our families were not informative for linkage and because of the likelihood of genetic heterogeneity.
Ravindranathan
A
A
Department of Neuroscience, University of Utah School of Medicine, Salt Lake City 84132.
Coon
H
H
DeLisi
L
L
Holik
J
J
Hoff
M
M
Brown
A
A
Shields
G
G
Crow
T
T
Byerley
W
W
D000293:Adolescent; D000328:Adult; D004276:DNA, Satellite / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011954:Receptors, Dopamine / Q000235:genetics*; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5; D012559:Schizophrenia / Q000235:genetics*
D004276:DNA, Satellite; C493605:DRD5 protein, human; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5