title: Experimental vitreous replacement with perfluorotri-n-propylamine.
abstract: OBJECTIVE
  To evaluate perfluorotri-n-propylamine, a perfluorocarbon oil, as a temporary vitreous replacement in rabbits.
  
  
  METHODS
  After undergoing gas compression vitrectomy, rabbits were injected with perfluorotri-n-propylamine for 24 hours or 2 weeks. The rabbits were evaluated clinically and with electroretinography. The globes were then enucleated and processed for histological evaluation.
  
  
  RESULTS
  Clinical results showed droplet dispersion in the 2-week but not in the 24-hour group. Histological evaluation showed no changes in the retinal pigment epithelium or photoreceptor outer segments. Foam cells were seen in the 2-week but not in the 24-hour group. There was a marked dampening of the electroretinographic response that normalized after the removal of the oil.
  
  
  CONCLUSIONS
  Perfluorotri-n-propylamine demonstrated no retinal toxic side effects in rabbits and is a promising liquid perfluorocarbon oil.
authors.affiliation: Department of Ophthalmology, University of Florida College of Medicine, Gainesville.
authors.forename: J S
authors.initials: JS
authors.lastname: Bryan
authors.forename: S M
authors.initials: SM
authors.lastname: Friedman
authors.forename: R N
authors.initials: RN
authors.lastname: Mames
authors.forename: C E
authors.initials: CE
authors.lastname: Margo
mesh_terms: D000818:Animals; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D005466:Fluorocarbons; D007267:Injections; D008297:Male; D010786:Photoreceptor Cells / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000473:pathology; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects
chemical_list: D005466:Fluorocarbons; C039422:perfluorotripropylamine