Interpretive criteria for DU-6859a disk diffusion tests using 5-micrograms disks.
In vitro disk diffusion test interpretive criteria were developed for DU-6859a, a new difluorinated quinolone, using a 5-micrograms disk. Included in the 494 organisms tested were 84 (17%) ciprofloxacin-resistant > or = 4 micrograms/ml) clinical isolates. The following interpretive criteria were proposed for two possible susceptible breakpoint minimum inhibitory concentrations: > or = 16 mm (< or = 2 micrograms/ml) = susceptible and < or = 12 mm (> or = 8 micrograms/ml) = resistant and; > or = 19 mm (< or = 1 microgram/ml) = susceptible and < or = 15 mm (> or = 4 micrograms/ml) = resistant. These criteria demonstrated > or = 97% absolute interpretive agreement between test methods with no major (false resistant) or very major (false susceptible) errors.
Jones
R N
RN
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Johnson
D M
DM
Erwin
M E
ME
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004058:Diffusion; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D015203:Reproducibility of Results
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C076246:sitafloxacin