[Experimental study of anti-radiation effects of interleukin-1 beta].
Therapeutical effect of human recombinant IL-1 beta on exposed CBA mice was shown. Single injection of IL-1 beta into mice exposed to LD70, LD80 and LD100 raised their 30-day survival by 60, 40 and 35%, respectively. Therapeutically effective doses of IL-1 beta were 100-200 micrograms/kg. Multiple injections of the preparation were ineffective.
Rogacheva
S A
SA
Simbirtsev
A S
AS
Muksinova
K N
KN
D000818:Animals; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D051381:Rats; D013997:Time Factors
D007375:Interleukin-1
Izuchenie protivoluchevogo deĭstviia interleĭkina-1 beta v éksperimente.