title: Supplementation trials with calcium citrate malate: evidence in favor of increasing the calcium RDA during childhood and adolescence.
abstract: The vast majority of peak adult bone mass is accumulated by the time longitudinal growth is complete. As peak bone mass is an important determinant of future fracture risk, the goal of the current calcium recommended dietary allowance during youth is to provide a calcium intake that allows individuals to reach their full genetic potential for acquiring skeletal mass. The advent of controlled trials of calcium supplementation and total body bone mass measurements in children and adolescents provide the first direct way of determining the amount of calcium necessary to achieve optimal skeletal accretion. These studies indicate that the current RDAs are insufficient to support optimal bone mass gain during growth and development. Based on the recent intervention trials, recommendations are made for an RDA of 1250 mg during childhood and 1450 mg during adolescence. These values are consistent with established calcium balance intake thresholds for growth during pre-adolescence and adolescence.
authors.affiliation: Procter & Gamble Company, Sharon Woods Technical Center, Cincinnati, OH 45242.
authors.forename: M B
authors.initials: MB
authors.lastname: Andon
authors.forename: T
authors.initials: T
authors.lastname: Lloyd
authors.forename: V
authors.initials: V
authors.lastname: Matkovic
mesh_terms: D000293:Adolescent; D000375:Aging / Q000378:metabolism; D001846:Bone Development / Q000187:drug effects*; D002118:Calcium; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002951:Citrates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019343:Citric Acid; D002986:Clinical Trials as Topic; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption; D008293:Malates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D009751:Nutritional Requirements
chemical_list: D002136:Calcium, Dietary; D002951:Citrates; D008293:Malates; D019343:Citric Acid; C083976:calcium citrate malate; D002118:Calcium