[The use of nimodipine in the acute period of a cerebral infarct].
Before and after intravenous administration of 1-1.5 mg nimotop 18 patients with acute brain infarction underwent EEG, integral body rheography, computed tomography and measurement of regional volumetric cerebral circulation (RVCC). Nimotop appeared to increase RVCC in the infarction zone, especially in low initial RVCC levels. The drug induced a shift to EEG normalization and a hypotensive effect, cerebral hemodynamics remaining without changes. Nimodipine-type calcium antagonists favourably affect brain perfusion and bioelectric activity which is promising for application in acute cerebral infarction.
Tomberg
T A
TA
Miagi
M A
MA
Kauba
T F
TF
Rekand
T E
TE
Kaasik
A E
AE
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004341:Drug Evaluation; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D009553:Nimodipine
O primenenii nimodipina v ostrom periode infarkta mozga.