title: [The therapeutic efficacy of sodium nucleinate and monoribonucleotides based on keratoconjunctival test data].
abstract: The possibility of using sodium nucleinate for the treatment of acute dysentery has been confirmed in experiments on guinea pigs with the use of the keratoconjunctival test as an experimental model. The capacity of sodium nucleinate to enhance the antibiotic sensitivity of shigellae isolated from infected eyes to kanamycin, tetracycline and chloramphenicol has been established. The effect produced by individual ribonucleotides contained in sodium nucleinate have been studied and found to be differently directed.
authors.forename: A M
authors.initials: AM
authors.lastname: Zemskov
authors.forename: B D
authors.initials: BD
authors.lastname: Trutnev
authors.forename: V P
authors.initials: VP
authors.lastname: Popova
authors.forename: G G
authors.initials: GG
authors.lastname: Salomakhin
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Dolzhanov
authors.forename: Iu Ia
authors.initials: IuIa
authors.lastname: Mikstaĭs
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D006168:Guinea Pigs; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D009696:Nucleic Acids / Q000627:therapeutic use*; D012074:Remission Induction; D012265:Ribonucleotides / Q000627:therapeutic use*; D012763:Shigella flexneri; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D012265:Ribonucleotides; C013683:sodium nucleinate
vernacular_title: Lechebnaia éffektivnost' nukleinata natriia i monoribonukleotidov po dannym keratokon''iunktival'noĭ proby.