Treatment of group E streptococci-induced lymphadenitis in swine by feeding various concentrations of chlortetracycline: relation of antibody with prevalence of abscesses.
Consumption of chlortetracycline (CTC) at concentration of 220 mg/kg of feed for 4 weeks in experiment 1 and at concentrations of 110 and 220 mg/kg for 3 weeks and 440 mg/kg for 2 weeks in experiment 2 failed to eliminate streptococci-induced lymphadenitis from swine referred to as principals. Abscesses, mostly in the head and neck, developed in at least a third of all swine in the various groups fed these CTC concentrations. Feeding of 220 mg of CTC/kg of feed in experiment 1 began 12 weeks after exposure of principals to an untypeable group E streptococci (GES; isolate 3X29A). In experiment 2, feeding of 110 and 220 mg of CTC/kg of feed began 5 weeks after exposure of principals to GES and feeding of 440 mg of CTC/kg of feed began 6 weeks after exposure. One or more cohabitating sentinel swine of experiment 1 and one or more sentinels in all groups of principals of experiment 2, except group 2, developed abscesses that were mostly in the head and neck. In experiment 2, correlation between serum GES antibody titer and development of one or more abscesses in the principals was highly significant (P < 0.01); however, correlation between antibody titer and abscesses in the sentinels only approached significance (P < 0.10).
Olson
L D
LD
Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211.
Miller
R B
RB
Schlink
G T
GT
D000038:Abscess / Q000139:chemically induced / Q000276:immunology / Q000662:veterinary*; D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D002751:Chlortetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D008199:Lymphadenitis / Q000188:drug therapy / Q000662:veterinary*; D015995:Prevalence; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy*; D013552:Swine; D013553:Swine Diseases
D000907:Antibodies, Bacterial; D002751:Chlortetracycline