Genetic resistance to lymphoma-leukemia: role of natural killer cells in the rejection of lymphoma grafts.
Lethally irradiated genetically resistant (C57 x AKR) mice, unlike non-resistant (C3H x AKR) mice, which display genetic resistance to transplantation of parental C57 bone marrow grafts (GR to BMT), also reject transplanted parental AKR lymphoma grafts (GR to lymphoma). Depletion of natural killer (NK) cell activity of resistant (C57 x AKR) mice by anti-asialo GM-1 serum abrogated the resistance, whereas stimulation of NK cell activity of non-resistant (C3H x AKR) mice by polyinosinic: polycytidillic acid (poly I:C) induced the resistance to parental AKR lymphoma grafts. This shows that NK cells contribute to GR of (C57 x AKR) hybrid mice to parental AKR lymphoma grafts. Further, these results indicate that NK cells which confer genetic resistance to bone marrow transplantation (GR to BMT) in lethally irradiated (C57 x AKR) hybrid mice, also mediate GR to lymphoma transplantation in these mice, thereby linking GR to BMT with GR to lymphoma-leukemia.
Datta
S K
SK
Department of Surgery, Baylor College of Medicine, Houston, Texas 77030.
Trentin
J J
JJ
D000818:Animals; D006084:Graft Rejection / Q000235:genetics*; D007113:Immunity, Innate / Q000187:drug effects / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology*; D007938:Leukemia / Q000235:genetics* / Q000276:immunology; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology / Q000601:surgery; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011066:Poly C / Q000494:pharmacology
D011066:Poly C