Neuroblastoma in the first year of life: clinical and biologic factors influencing outcome.
The survival for infants less than 1 year of age with neuroblastoma is twice that of older children. This report describes 70 babies with neuroblastoma who experienced an 84% survival. Survival was 100% for stages I, II, and III, 81% for stage IV-S, and 50% for stage IV. Most survivors had favorable biologic characteristics including spontaneous regression, favorable Shimada histology, normal first chromosome, aneuploid tumors, absent or low N-myc oncogene expression, and normal serum ferritin levels.
Grosfeld
J L
JL
Department of Surgery, Indiana University School of Medicine, Indianapolis.
Rescorla
F J
FJ
West
K W
KW
Goldman
J
J
D014408:Biomarkers, Tumor / Q000032:analysis*; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D011003:Ploidies; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D015996:Survival Rate
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D016271:Proto-Oncogene Proteins c-myc