Selective enhancement of experimental rat brain tumors with Gd-TPPS.
The synthetic metalloporphyrin gadolinium (III)-tetraphenylporphine sulfonate (TPPS) was successfully used as a contrast agent for in vivo magnetic resonance (MR) imaging of rat brain glioma. After injection of Gd-TPPS, the signal intensity of experimental rat brain glioma distinctly increased on T1-weighted MR images, an effect similar to that produced by the clinically applied MR imaging contrast agent gadolinium diethylenetriaminepentaacetic acid (DTPA). In contrast to other contrast agents studied (Gd-DTPA, manganese [III]-TPPS), Gd-TPPS produced hypointensity in glioma on T2-weighted images. The tumor-selective accumulation of paramagnetic Gd-TPPS in glioma shortened T1 by 53%, from 1,315 msec +/- 199 to 628 msec +/- 106, and T2 by 34%, from 86 msec +/- 4 to 57 msec +/- 5 (2 days after injection of 0.25 mmol/kg Gd-TPPS). The relaxation times of normal cortex, striatum, corpus callosum, and temporal muscle were not significantly affected. As a result, gliomas appeared hyperintense on T1-weighted images and hypointense on T2-weighted images. Owing to the strong effect of Gd-TPPS on the T2 of glioma, normal brain tissue, tumor, and peritumorous edema could be distinguished on T2-weighted images alone.
Bockhorst
K
K
Max-Planck-Institut für Neurologische Forschung, Köln, Germany.
Els
T
T
Hoehn-Berlage
M
M
D000818:Animals; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese; D008665:Metalloporphyrins / Q000138:chemical synthesis; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011166:Porphyrins; D051381:Rats; D011916:Rats, Inbred F344
D003287:Contrast Media; D008665:Metalloporphyrins; D009942:Organometallic Compounds; D011166:Porphyrins; C088919:gadolinium(III)-tetraphenylporphine sulfonate; C016136:tetraphenylporphine sulfonate; D008345:Manganese; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA