title: LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains.
abstract: We here report the sequence of a yeast gene LRG1 whose deduced amino acid sequence contains sequence motifs similar to LIM domain proteins in the amino-terminal, and to rho/rac GTPase activating proteins (rho/racGAP's) in the carboxy-terminal part. LRG1 expression is differentially regulated showing a peak of expression in sporulating cells. Gene disruption experiments indicate that the gene is not essential and may play a role during mating.
authors.affiliation: German Cancer Research Center, Heidelberg.
authors.forename: L
authors.initials: L
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Wells
authors.forename: C P
authors.initials: CP
authors.lastname: Hollenberg
authors.forename: W
authors.initials: W
authors.lastname: Piepersberg
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004271:DNA, Fungal / Q000737:chemistry / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000737:chemistry*; D020690:GTPase-Activating Proteins; D015870:Gene Expression; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D017385:Sequence Homology; D013172:Spores, Fungal / Q000502:physiology*; D020744:rac GTP-Binding Proteins
chemical_list: D004271:DNA, Fungal; D004268:DNA-Binding Proteins; D020690:GTPase-Activating Proteins; C088938:LRG1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins