title: Thyroid hormone metabolism. A comparative evaluation.
abstract: Knowledge of thyroid hormone and iodide metabolism is derived from a combination of in vivo and in vitro studies in a variety of mammalian species including cats, dogs, and humans. Each species provides a unique opportunity to investigate various aspects of normal or altered thyroid hormone physiology. Availability of sensitive and specific human TSH assays has allowed detailed studies of the human hypothalamic-pituitary-thyroid axis which have not been possible in cats and dogs to date. Similarities and differences of thyroid hormone metabolism in dogs, cats, and humans provide the basis for a better understanding of normal physiology as well as shedding light on the significance of changes induced by spontaneous or induced thyroidal and nonthyroidal disorders.
authors.affiliation: Department of Medicine, University of Southern California, Los Angeles.
authors.forename: E M
authors.initials: EM
authors.lastname: Kaptein
authors.forename: M T
authors.initials: MT
authors.lastname: Hays
authors.forename: D C
authors.initials: DC
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000378:metabolism; D000830:Animals, Laboratory / Q000378:metabolism; D002415:Cats / Q000378:metabolism*; D004285:Dogs / Q000378:metabolism*; D006801:Humans; D007454:Iodides / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D013045:Species Specificity; D013959:Thyroid Diseases / Q000378:metabolism / Q000662:veterinary; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D007454:Iodides; D013963:Thyroid Hormones