alpha-Interferon in myelofibrosis: a case report.
A patient with advanced myeloid metaplasia was treated with alpha-interferon (29 months) with a remarkable response. He had anaemia, thrombocytopenia and hepatosplenomegaly with infarction. The initial bone marrow showed replacement with fibrosis with no evident haemopoietic cells. Post-therapy, the patient became asymptomatic, transfusion independent and had normal blood counts. The repeat bone marrow was 30% cellular with 1 + reticulin and no fibrosis. Treatment was well tolerated without appreciable side-effects. These results indicate that prolonged therapy with alpha-interferon can improve haemopoiesis and reverse marrow fibrosis.
Dalla
K P
KP
Western Pennsylvania Cancer Institute, Western Pennsylvania Hospital, Pittsburgh 15224.
Zeigler
Z R
ZR
Shadduck
R K
RK
D001707:Biopsy, Needle; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000209:etiology / Q000473:pathology / Q000628:therapy*
D016898:Interferon-alpha