Oxygen radicals and myocardial stunning.
There is compelling, although indirect, evidence that oxygen free radicals, generated during ischemia as well as upon reperfusion and reoxygenation of the ischemic heart, contribute to the reversible ventricular dysfunction characterized as myocardial stunning. Evidence of cell membrane damage as well as depression of sarcoplasmic reticulum and mitochondrial function with resulting calcium overload of the cell may be a result of lipid peroxidation of the cell by free radical products. Radical scavenger enzymes have been shown to greatly reduce the appearance of mRNA of a stress response protein (heat shock protein 71) in a pig heart model of stunning. The potential role for the introduction of antioxidant enzymes or stress protein in the cell is presented as a possible strategy for attenuating free radical damage during postischemic reflow.
Gardner
T J
TJ
Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D017682:Myocardial Stunning / Q000503:physiopathology* / Q000517:prevention & control; D010100:Oxygen / Q000378:metabolism*; D016276:Ventricular Function
D000975:Antioxidants; D005609:Free Radicals; D010100:Oxygen