Toxins that inhibit host protein synthesis.
Methods have been described that are sufficient to determine if a bacterial protein toxin is a selective inhibitor of eukaryotic protein synthesis, and, if so, which part of the overall process is affected. More defined assays are presented for studying the steps of peptide elongation as this is where such toxins have been shown to act.
Obrig
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Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, New York 14642.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002474:Cell-Free System; D005057:Eukaryotic Cells / Q000187:drug effects* / Q000378:metabolism; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D012270:Ribosomes / Q000187:drug effects; D014709:Vero Cells / Q000187:drug effects / Q000378:metabolism
D001427:Bacterial Toxins; D011500:Protein Synthesis Inhibitors