A simple method for the determination of YM060 in plasma and urine by high performance liquid chromatography.
We developed a simple method for the determination of YM060, a new 5-HT3 receptor antagonist, in plasma and urine. The method has good accuracy and precision, and sufficient sensitivity to allow use in pharmacokinetic studies of YM060 in humans and laboratory animals.
Miura
H
H
Drug Metabolism Department, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan.
Takeshige
T
T
Kobayashi
S
S
Higuchi
S
S
D000818:Animals; D001562:Benzimidazoles / Q000097:blood* / Q000493:pharmacokinetics / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004285:Dogs; D006801:Humans; D051381:Rats; D012702:Serotonin Antagonists
D001562:Benzimidazoles; D012702:Serotonin Antagonists; C071315:ramosetron