Hispidulin protection against hepatotoxicity induced by bromobenzene in mice.
The effects of the natural flavonoid hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) on bromobenzene-induced hepatotoxicity in mice were investigated. We found a correlation between liver injury and hepatic lipid peroxidation besides a strong liver glutathione depletion due to the toxicant. Hispidulin at doses between 50 and 150 mg/kg i.p. compared favourably with the reference compound N-acetyl-L-cysteine for inhibition of liver injury and lipid peroxidation. The flavonoid at the highest dose tested was also able to counteract reduced glutathione depletion induced by bromobenzene in starved mice. These hepatoprotective effects can be related to the antioxidant properties of hispidulin.
Ferrándiz
M L
ML
Department of Pharmacology, University of Valencia, Spain.
Bustos
G
G
Payá
M
M
Gunasegaran
R
R
Alcaraz
M J
MJ
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D001969:Bromobenzenes / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D047309:Flavones; D005419:Flavonoids / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice
D001969:Bromobenzenes; D047309:Flavones; D005419:Flavonoids; D008054:Lipid Peroxides; C032036:bromobenzene; D005978:Glutathione; C055957:hispidulin; D000111:Acetylcysteine