[Dysregulation of in vitro TNF-beta production in insulin-dependent diabetes mellitus].
The possible role of tumor necrosis factors (TNF) in autoimmunity led us to explore the relationship between TNF production, polymorphism of the TNF-beta gene and type one diabetes. In the diabetic group we found a low production of TNF-beta. This abnormality appeared not to be exclusively related to the TNF-beta gene and could be also due to polymorphic regulatory sequences in the major histocompatibility complex region.
Feugeas
J P
JP
Laboratoire de Biochimie, Hôpital F.-Guyon, Ile de la Réunion, France.
Dosquet
C
C
Wautier
J L
JL
Montchamp-Moreau
C
C
Krishnamoorthy
R
R
Caillens
H
H
D000293:Adolescent; D016207:Cytokines / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000378:metabolism*; D008285:Major Histocompatibility Complex; D008297:Male; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha
Dysrégulation de la production in vitro de TNF-beta au cours du diabète insulinodépendant.