title: Local bacillus Calmette-Guérin therapy for bovine vulval papilloma and carcinoma.
abstract: Thirty cows from a pedigree Friesian dairy herd with bovine vulva papilloma and carcinoma were treated by intralesional injections of live bacillus Calmette-Guérin (BCG). This treatment induced total regression of all of six carcinomas. Whilst, after treatment, limited regression was also observed in advanced papillomas, BCG has little or no effect on the early stages of papillomas. This is the first study of BCG therapy in this type of cancer.
authors.affiliation: Faculty of Veterinary Science, University of Zimbabwe, Harare.
authors.forename: F W
authors.initials: FW
authors.lastname: Hill
authors.forename: V P
authors.initials: VP
authors.lastname: Rutten
authors.forename: M H
authors.initials: MH
authors.lastname: Hoyer
authors.forename: W R
authors.initials: WR
authors.lastname: Klein
authors.forename: J W
authors.initials: JW
authors.lastname: Koten
authors.forename: P A
authors.initials: PA
authors.lastname: Steerenberg
authors.forename: E J
authors.initials: EJ
authors.lastname: Ruitenberg
authors.forename: W
authors.initials: W
authors.lastname: Den Otter
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000628:therapy*; D005260:Female; D007167:Immunotherapy; D015552:Injections, Intralesional; D007279:Injections, Subcutaneous; D010212:Papilloma / Q000628:therapy* / Q000662:veterinary*; D014846:Vulvar Neoplasms / Q000628:therapy* / Q000662:veterinary*
chemical_list: D001500:BCG Vaccine