[Phosphorus-containing inhibitors of penicillin acylase. 2. Design, synthesis and study of the hydrolytic stability of phosphonic acid derivatives as potential inhibitors of penicillin acylase].
Phosphonate and phosphonoamidate derivatives of benzylphosphonic acids were synthesized as potential inhibitors of penicillin acylase (EC 3.5.1.11) proceeding from the concept of transition-state analogues. The compounds obtained are not the substrates of the enzyme and they are stable under conditions of enzyme activity testing.
Solodenko
V A
VA
Tserniuk
V N
VN
Kukhar'
V P
VP
D015195:Drug Design; D004355:Drug Stability; D006868:Hydrolysis; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*; D010399:Penicillin Amidase / Q000037:antagonists & inhibitors*; D010758:Phosphorus / Q000032:analysis*
D063065:Organophosphonates; D010758:Phosphorus; D010399:Penicillin Amidase
Fosforsoderzhashchie ingibitory penitsillinatsilazy. 2. Dizaĭn, sintez i izuchenie gidroliticheskoĭ stabil'nosti proizvodnykh fosfonovykh kislot kak potentsial'nykh ingibitorov penitsillinatsilazy.