M-estimation in cross-over trials.
A robust procedure, combined M-estimation, is proposed for analyzing cross-over data with possible within- and between-subject outliers. The mean squared error properties of these combined M-estimates for direct treatment effect contrasts and carryover treatment effect contrasts are examined through simulation studies. They are found to be superior to those of the generalized least squares estimates when there are possible within- and between-subject outliers.
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Hoechst-Roussel Pharmaceuticals Inc., Somerville, New Jersey 08876.
D000547:Amantadine / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001699:Biometry; D002986:Clinical Trials as Topic / Q000379:methods*; D005541:Forced Expiratory Volume; D006801:Humans; D016018:Least-Squares Analysis; D010300:Parkinson Disease / Q000188:drug therapy
D000547:Amantadine