title: The case of TDI-induced reactive airway dysfunction syndrome with the presence of specific IgE antibodies.
abstract: Reactive Airways Dysfunction Syndrome defines a chronic, nonallergic bronchoconstriction syndrome due to a brief, single inhalation exposure to highly concentrated irritant factors. Here we describe a case history of RADS in patient exposed to isocyanates with the presence of specific IgE antibodies. According to some authors only RAST ratio > 2.0 is a criterion of an allergic origin or TDI-induced respiratory disease, and a lower ratio is believed to be a proof only of an exposure. Negative effects of bronchial specific provocative tests confirmed the insignificance of the IgE-mediated mechanism in RADS and on the other side emphasized the possibility of incorrect diagnosis of TDI-induced bronchospastic syndromes.
authors.affiliation: Institute of Occupational Medicine, Lódź, Poland.
authors.forename: C
authors.initials: C
authors.lastname: Palczyński
authors.forename: P
authors.initials: P
authors.lastname: Górski
authors.forename: J
authors.initials: J
authors.lastname: Jakubowski
mesh_terms: D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D016084:Bronchoconstriction / Q000187:drug effects; D002908:Chronic Disease; D003371:Cough / Q000139:chemically induced / Q000276:immunology; D003951:Diagnostic Errors; D004417:Dyspnea / Q000139:chemically induced / Q000175:diagnosis / Q000276:immunology; D006632:Histamine; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D011140:Polyurethanes; D011852:Radioallergosorbent Test; D012498:Sanitary Engineering; D013577:Syndrome; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects* / Q000276:immunology
chemical_list: D011140:Polyurethanes; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E; D006632:Histamine