title: 2,6-Disubstituted aryl carboxylic acids, leaving groups "par excellence" for benzisothiazolone inhibitors of human leukocyte elastase.
authors.affiliation: Department of Medicinal Chemistry, Sterling Winthrop Pharmaceutical Research Division, Collegeville, Pennsylvania 19426-0900.
authors.forename: C
authors.initials: C
authors.lastname: Subramanyam
authors.forename: M R
authors.initials: MR
authors.lastname: Bell
authors.forename: P
authors.initials: P
authors.lastname: Carabateas
authors.forename: J J
authors.initials: JJ
authors.lastname: Court
authors.forename: J A
authors.initials: JA
authors.lastname: Dority
authors.forename: E
authors.initials: E
authors.lastname: Ferguson
authors.forename: R
authors.initials: R
authors.lastname: Gordon
authors.forename: D J
authors.initials: DJ
authors.lastname: Hlasta
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Saindane
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D019272:Leukocyte Elastase; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D002264:Carboxylic Acids; D011480:Protease Inhibitors; D013844:Thiazoles; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; C015699:1,2-benzisothiazoline-3-one