[Myoelectric manifestations of duodenogastric dyskinesia in pentagastrin-induced ulceration].
Ulcerogenic dose (0.2 mg/kg) of Pentagastrin administrated subcutaneously in chronic experiments in rabbits resulted in duodenogastric dyskinesia manifested by duodenal activation (150%) and by inhibition of the sphincter and gastric activity (25%, 41%). Pentagastrin effects lead to origin of 3-11 ulcus on the gastric mucous membrane. Thus, one of the possible mechanisms of the gastric ulceration is duodenogastric dyskinesia, based on myoelectrical activity retrograde spriding in response to pentagastrin.
Shemerovskiĭ
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KA
D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000503:physiopathology*; D004567:Electrodes, Implanted; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010418:Pentagastrin; D011817:Rabbits; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology*
D010418:Pentagastrin
Mioélektricheskie proiavleniia duodenogastral'noĭ diskinezii pri iazvoobrazovanii, vyzvannom pentagastrinom.