Liposomes as a carrier for oral administration of insulin: effect of formulation factors.
The present work was undertaken to study the effect of liposome formulation factors on its efficiency as a carrier for oral administration of insulin. The insulin-liposomes were prepared by two methods: solvent evaporation hydration and solvent spherule evaporation, with various variables such as concentration of insulin (I), lecithin (L), cholesterol (C), and Tween-80 (T). It was found that the insulin-liposomes when administered orally could produce hypoglycaemia. Variation in liposome composition was found to affect the efficiency of liposome as a carrier for oral administration of insulin. A liposome system containing L, 100 mg; C, 20 mg; I, 150 units; T, 1 per cent v/v, and prepared by the solvent spherule evaporation method was found to be most effective. The effect of insulin-liposome had prolonged action in diabetes-induced rabbits compared with that in normal rabbits. The results of the insulin-liposome system were comparable with the action of 1 unit of insulin/kg administered subcutaneously.
Choudhari
K B
KB
Department of Pharmaceutical Sciences, Nagpur University Campus, India.
Labhasetwar
V
V
Dorle
A K
AK
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D002784:Cholesterol / Q000737:chemistry; D004337:Drug Carriers; D005260:Female; D007328:Insulin / Q000008:administration & dosage* / Q000494:pharmacology; D008081:Liposomes; D008297:Male; D010713:Phosphatidylcholines / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D011817:Rabbits; D012997:Solvents
D001786:Blood Glucose; D004337:Drug Carriers; D007328:Insulin; D008081:Liposomes; D010713:Phosphatidylcholines; D011136:Polysorbates; D012997:Solvents; D002784:Cholesterol