[Effects of N-acetylasparaginic acid during frontal lobectomy in the rat: antiamnestic action and effect on monoamine level].
Effects of N-acetyl-aspartic acid (NAA) on the behaviour models "open field", passive avoidance test and content of monoamines and their metabolites in the brain areas on the 9-th day after frontal decortication were studied. NAA (50 mg/kg), i.p., daily, 9 days) exerted antiamnestic effect in decorticated rats, evaluated in passive avoidance test. Corresponding changes in concentration of serotonin and 5-hydroxyindolacetic acid in the brain of decorticated rats were also seen.
Grekhova
T V
TV
Romanova
G A
GA
Gaĭnetdinov
R R
RR
Kudrin
V S
VS
Raevskiĭ
K S
KS
D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D005625:Frontal Lobe / Q000601:surgery*; D008297:Male; D051381:Rats
D015306:Biogenic Monoamines; D001224:Aspartic Acid; C000179:N-acetylaspartate
Effekty N-atsetilasparaginovoĭ kisloty pri frontal'noĭ lobéktomii mozga krys: antiamnesticheskoe deĭstvie i vliianie na soderzhanie monoaminov.