Improvement of sleep apnoea due to acromegaly during short-term treatment with octreotide.
Two acromegalic patients suffering from severe obstructive sleep apnoea syndrome were treated with the long-acting somatostatin analogue octreotide. Daytime sleepiness and fatigue improved within a few days. Repeat sleep studies performed after octreotide treatment revealed more confluent sleep with a shorter duration of sleep apnoea. Nocturnal hypoxaemia improved in one patient. Octreotide might be an effective noninvasive treatment for sleep apnoea of acromegaly.
Leibowitz
G
G
Department of Endocrinology and Metabolism, Hebrew University Hadassah Medical Centre, Jerusalem, Israel.
Shapiro
M S
MS
Salameh
M
M
Glaser
B
B
D000172:Acromegaly / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects*; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000503:physiopathology*
D015282:Octreotide