title: The effect of biotin supplementation on ascorbic acid metabolism in chickens.
abstract: The objective of the paper was to show the effect of supplementation of biotin (vitamin H) on vitamin C synthesis in chickens. A significant vitamin C increase was observed in kidneys, adrenal glands, liver, glandular stomach, jejunum wall, caecum wall and in blood plasma. A clear increase in the level of D-glucuronic acid was observed in adrenal glands, jejunum wall, and caecum wall. The activity of L-gulono-gamma-oxidase enzyme clearly increased in adrenal glands, jejunum wall and in stomach. The increase in vitamin C synthesis was found in adrenal glands, jejunum, caecum wall and stomach, but accumulation of vitamin C took place in liver and kidneys. The data imply that the supplementation of biotin accelerates vitamin C synthesis in chickens. Biotin, increasing vitamin C level in the organism, indirectly affects all the processes taking place with the participation of vitamin C.
authors.affiliation: Department of Animal Physiology, Faculty of Veterinary Medicine, Agricultural University, Lublin, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Lechowski
authors.forename: B
authors.initials: B
authors.lastname: Nagórna-Stasiak
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000096:biosynthesis*; D001710:Biotin / Q000008:administration & dosage / Q000494:pharmacology*; D002645:Chickens / Q000378:metabolism*; D004032:Diet; D005753:Gastric Mucosa / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D020723:Glucuronic Acid; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D050544:L-Gulonolactone Oxidase; D008099:Liver / Q000378:metabolism; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism
chemical_list: D005965:Glucuronates; D001710:Biotin; D020723:Glucuronic Acid; D013401:Sugar Alcohol Dehydrogenases; D050544:L-Gulonolactone Oxidase; D001205:Ascorbic Acid