title: Crystallization on intraocular lens surfaces associated with the use of Healon GV.
abstract: OBJECTIVE
  To describe a series of patients who had visually significant crystalline deposits on their intraocular lenses during cataract surgery with the use of Healon GV (a high concentration and high molecular-weight hyaluronate sodium).
  
  
  METHODS
  Patients were examined for crystalline deposits on their intraocular lenses. These deposits were compared with intraocular lens type, viscoelastic solutions, any other intraocular substance used, type of surgery, and perioperative medications.
  
  
  RESULTS
  In the 11 patients with documented changes (six photographically), the only consistent finding was the use of Healon GV. Furthermore, since we discontinued the use of Healon GV, we have not seen a recurrence of these deposits in more than 500 consecutive patients. The deposits could last a long time (at least 6 months) if sequestered by the posterior capsule, and they are believed to be visually significant at times (Snellen visual acuity of 20/40 or worse).
  
  
  CONCLUSIONS
  Healon GV use is associated with a new clinical finding of crystalline deposits on intraocular lenses. These deposits can be clinically significant.
authors.affiliation: John A. Moran Eye Center, Department of Pharmacy Services, University of Utah Health Sciences Center, Salt Lake City.
authors.forename: M K
authors.initials: MK
authors.lastname: Jensen
authors.forename: A S
authors.initials: AS
authors.lastname: Crandall
authors.forename: N
authors.initials: N
authors.lastname: Mamalis
authors.forename: R J
authors.initials: RJ
authors.lastname: Olson
mesh_terms: D000368:Aged; D002387:Cataract Extraction; D011232:Chemical Precipitation; D003460:Crystallization; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007910:Lenses, Intraocular; D008297:Male; D011183:Postoperative Complications / Q000473:pathology; D012826:Silicone Elastomers; D014792:Visual Acuity
chemical_list: D012826:Silicone Elastomers; D006820:Hyaluronic Acid