title: Cytogenetic studies in five patients with Sézary syndrome.
abstract: A cytogenetic study was performed in five patients with Sézary syndrome. Metaphases were obtained from a phytohemagglutinin-stimulated lymphocyte culture. The five patients showed abnormal karyotypes. The chromosomes preferentially involved in numerical aberrations were chromosomes 10 (monosomy) and 13 (monosomy); involved in structural changes were chromosomes 1, 2, 4, 6, and 14. In our series, all patients showed progression of the disease.
authors.affiliation: Laboratori de Citologia Hematològica, Hospital Central L'Aliança, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Solé
authors.forename: S
authors.initials: S
authors.lastname: Woessner
authors.forename: T
authors.initials: T
authors.lastname: Vallespi
authors.forename: A
authors.initials: A
authors.lastname: Pérez Losada
authors.forename: L
authors.initials: L
authors.lastname: Florensa
authors.forename: D
authors.initials: D
authors.lastname: Irriguible
authors.forename: J
authors.initials: J
authors.lastname: Vila
authors.forename: J
authors.initials: J
authors.lastname: Sans-Sabrafen
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012751:Sezary Syndrome / Q000235:genetics*