Intracerebral hemorrhages and infarction induced by a murine leukemia virus is influenced by host determinants within endothelial cells.
The strain and developmental parameters that control susceptibility to murine leukemia virus (MuLV)-induced intracerebral hemorrhages and infarction were studied using the endothelial cell tropic MuLV TR1.3. Inoculated animals displayed an absolute age dependence on the development of intracerebral vascular disease; however, other genetic determinants affected the timing and magnitude of susceptibility to neurologic disease. BALB/c mice were susceptible to neurologic disease only when inoculated prior to Day 4 postpartum. In contrast, Swiss/NIH and C3H/HeN mice consistently showed a less virulent phenotype and were only susceptible when infected prior to Day 3 postpartum. These studies demonstrate that susceptibility to TR1.3 murine leukemia virus-induced neurologic disease is regulated by age- and strain-dependent factors encoded within cerebral endothelial cells.
Park
B H
BH
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104.
Lavi
E
E
Gaulton
G N
GN
D000367:Age Factors; D000818:Animals; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002544:Cerebral Infarction / Q000209:etiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D009052:Leukemia Virus, Murine; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D012192:Retroviridae Infections / Q000150:complications*; D013045:Species Specificity; D014412:Tumor Virus Infections / Q000150:complications*