[Analytic study of the reliability of an integrated mineralometric and biochemical system in the dynamic evaluation of the bone mineral content after menopause].
OBJECTIVE
The purpose of the present study was to determine the accuracy of Osteometer diagnostic test to estimate the rate of postmenopausal bone loss (% per year) by means of combined evaluation of mineralometric and biochemical data of bone turnover.


METHODS
This was a one-year analytic study of 58 post-menopausal, apparently health, women whose last spontaneous menstrual period was at least 12 months before study entry. Bone mineral content in the forearm and biochemical indicators of calcium metabolism in urine and serum were periodically assessed.


METHODS
Bone Mineral Content (BMC), plasmatic estradiol, FSH, LH, Fasting Urine Hydroxyproline/Creatinine (FU Hpr/Cr), Fasting Urine Calcium/Creatinine (FU Ca/Cr), serum bone Gla protein (sBGP), serum Alkaline Phosphatase (sAP) were measured in all subjects.


RESULTS
One year after the first evaluation (BMC measurement and biochemical markers of bone turnover evaluation), percent changes of bone mineral content was compared to estimation of annual bone loss by Osteometer diagnostic test. The data show that at first evaluation it was predicted an annual bone loss of 1.2 +/- 0.3%. Periodically monitored after 1 year the same patients reported a mean decrease of 0.8 +/- 0.1% of bone mineral content. If so, no statistically differences were found between data predicted and data evaluated at control one year after.


CONCLUSIONS
The use of Osteometer Diagnostic test, using BMC measurements of forearm and biochemical parameters, represents a safe and simply method to detect post-menopausal women and its permits to identify fast bone mass looser among post-menopausal women.
Carone
D
D
Reparto di Ginecologia ed Ostetricia, IRCCS S. De Bellis, Castellana Grotte Bari.
Miglionico
F
F
Vizziello
G
G
Fanizza
G
G
D015502:Absorptiometry, Photon; D015519:Bone Density; D005260:Female; D005598:Fractures, Spontaneous; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000378:metabolism; D010052:Ovariectomy; D017698:Postmenopause / Q000378:metabolism*; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking
Studio analitico sull'affidabilità di un sistema integrato mineralometrico e biochimico nella valutazione dinamica del contenuto minerale osseo dopo la menopausa.