Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice.
To elucidate the role of mitochondrial oxidative phosphorylation in neuronal aging, we have studied the activity of the respiratory complexes in the brain of young, adult and old mice. In synaptic mitochondria, we found a significant decrease in complexes IV (29%, P < 0.001) and V (21%, P < 0.01) in old as compared with adult mice. Nonsynaptic mitochondria also showed a senescent decrease in complexes I (15%, P < 0.01), II + III (34%, P < 0.01) and IV (17%, P < 0.01) activities. These findings suggest a dysfunction in mitochondrial oxidative phosphorylation in brain aging.
Ferrándiz
M L
ML
Instituto de Neurociencias, Facultad de Medicina, Universidad de Alicante, Spain.
Martínez
M
M
De Juan
E
E
Díez
A
A
Bustos
G
G
Miquel
J
J
D000332:Aerobiosis; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D004579:Electron Transport / Q000502:physiology; D005260:Female; D007202:Indicators and Reagents; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D013569:Synapses / Q000201:enzymology / Q000378:metabolism
D007202:Indicators and Reagents