title: Humoral immune response to the Trypanosoma cruzi complement regulatory protein as an indicator of parasitologic clearance in human Chagas' disease.
abstract: Immunoprecipitation of the purified 160-kDa complement regulatory protein of Trypanosoma cruzi by Chagas' disease patient sera was examined as a possible correlate of the complement-mediated lysis test and as an indicator of parasite clearance. The results presented demonstrate that assessment of the humoral response to this antigen is a useful indicator of parasite clearance and may be particularly helpful in the assessment of some patients for whom other serological tests produce ambiguous results.
authors.affiliation: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261.
authors.forename: K A
authors.initials: KA
authors.lastname: Norris
authors.forename: L M
authors.initials: LM
authors.lastname: Galvão
authors.forename: J E
authors.initials: JE
authors.lastname: Schrimpf
authors.forename: J R
authors.initials: JR
authors.lastname: Cançado
authors.forename: A U
authors.initials: AU
authors.lastname: Krettli
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D015800:Protozoan Proteins / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D015800:Protozoan Proteins; D003165:Complement System Proteins