title: Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium.
abstract: Immunohistochemical study of bcl-2 protein immunoreactivity in human non-neoplastic mesothelium (44 cases) and in malignant mesothelioma (62 cases) using a murine monoclonal antibody (clone 124) showed cytoplasmic immunoreactivity for bcl-2 protein in five cases of malignant mesothelioma. Non-neoplastic mesothelium was not immunoreactive. Immunoreactivity for bcl-2 protein does not add useful prognostic information in malignant mesothelioma since survival times of bcl-2 positive and bcl-2 negative cases did not differ. Nevertheless, the detection of bcl-2 protein in malignant mesothelioma might be useful for the differentiation from reactive mesothelium.
authors.affiliation: Department of Pathology, University Hospital of Antwerp, University of Antwerp, Edegem, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Segers
authors.forename: M
authors.initials: M
authors.lastname: Ramael
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
authors.forename: J
authors.initials: J
authors.lastname: Weyler
authors.forename: J
authors.initials: J
authors.lastname: Van Meerbeeck
authors.forename: P
authors.initials: P
authors.lastname: Vermeire
authors.forename: E
authors.initials: E
authors.lastname: Van Marck
mesh_terms: D004848:Epithelium / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000737:chemistry* / Q000401:mortality; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D019253:Proto-Oncogene Proteins c-bcl-2; D015996:Survival Rate
chemical_list: D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2