title: Concentrations of ceftriaxone in cerebrospinal fluid of children with meningitis receiving dexamethasone therapy.
abstract: The penetration of ceftriaxone into cerebrospinal fluid (CSF) was studied with 11 children (mean age: 2 years, 4 months; range: 4 months to 8 years) with meningitis, receiving dexamethasone (0.15 mg/kg of body weight intravenously four times daily) as adjunctive therapy. Ceftriaxone was given intravenously at doses of 50 mg/kg twice daily to patients < 18 months old and 100 mg/kg once daily to patients > or = 18 months old. CSF was collected after 1 day of treatment at the expected peak concentration of ceftriaxone in CSF. Concentrations of ceftriaxone in CSF ranged from 0.7 to 9.2 mg/liter, with a mean value of 4.0 (standard deviation [SD], 2.9) mg/liter. Values were significantly higher for patients with CSF glucose levels of < 1 mmol/liter on admission to the hospital than for patients with CSF glucose levels of > or = 1 mmol/liter (mean values of 7.1 [SD, 2.2] mg/liter versus 2.2 [SD, 1.1] mg/liter; P < 0.001). After 1 day of treatment, ceftriaxone concentrations in the CSF of children receiving dexamethasone are similar to the mean values reported for children not treated with dexamethasone.
authors.affiliation: Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Gaillard
authors.forename: V
authors.initials: V
authors.lastname: Abadie
authors.forename: G
authors.initials: G
authors.lastname: Cheron
authors.forename: F
authors.initials: F
authors.lastname: Lacaille
authors.forename: B
authors.initials: B
authors.lastname: Mahut
authors.forename: C
authors.initials: C
authors.lastname: Silly
authors.forename: V
authors.initials: V
authors.lastname: Matha
authors.forename: C
authors.initials: C
authors.lastname: Coustere
authors.forename: F
authors.initials: F
authors.lastname: Lokiec
mesh_terms: D002443:Ceftriaxone / Q000008:administration & dosage / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000627:therapeutic use*; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000188:drug therapy
chemical_list: D002443:Ceftriaxone; D003907:Dexamethasone; D005947:Glucose