title: Sufentanil pharmacokinetics in young adult and elderly surgical patients.
abstract: Sufentanil 3 microgram kg-1 was administered as an intravenous (i.v.) bolus to 12 elderly patients, aged 65-87 years and 12 young adults, 17-43 years of age, all ASA class I-II, scheduled for orthopaedic surgery. Plasma sufentanil concentrations were measured by a specific radioimmunoassay. Plasma concentration time-curves for the young adult and the elderly groups were superimposible. Pharmacokinetic parameters were calculated from the derived compartmental models. Elimination half-lives, clearance and total volumes of distribution were calculated with non-compartment methods. The major pharmacokinetic parameters, elimination half-life, clearance and volume of distribution did not differ between both groups. The age-related differences in the action of sufentanil cannot be explained by its pharmacokinetic properties.
authors.affiliation: Hospital Eemland-Locatie De Lichtenberg, Amersfoort, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Helmers
authors.forename: L
authors.initials: L
authors.lastname: van Leeuwen
authors.forename: W W
authors.initials: WW
authors.lastname: Zuurmond
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000771:Anesthesia, Intravenous; D001842:Bone and Bones / Q000601:surgery; D005260:Female; D006207:Half-Life; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D017409:Sufentanil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D017409:Sufentanil