title: Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: A K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: W J
authors.initials: WJ
authors.lastname: Thompson
authors.forename: P M
authors.initials: PM
authors.lastname: Fitzgerald
authors.forename: J C
authors.initials: JC
authors.lastname: Culberson
authors.forename: M G
authors.initials: MG
authors.lastname: Axel
authors.forename: S P
authors.initials: SP
authors.lastname: McKee
authors.forename: J R
authors.initials: JR
authors.lastname: Huff
authors.forename: P S
authors.initials: PS
authors.lastname: Anderson
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D005663:Furans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D006860:Hydrogen Bonding; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism; D019258:Saquinavir
chemical_list: D005663:Furans; D017320:HIV Protease Inhibitors; D007546:Isoquinolines; D011804:Quinolines; C088801:L 739594; C018674:tetrahydrofuran; D016333:HIV Protease; D019258:Saquinavir