title: Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
abstract: Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor (M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: W J
authors.initials: WJ
authors.lastname: de Villiers
authors.forename: I P
authors.initials: IP
authors.lastname: Fraser
authors.forename: D A
authors.initials: DA
authors.lastname: Hughes
authors.forename: A G
authors.initials: AG
authors.lastname: Doyle
authors.forename: S
authors.initials: S
authors.lastname: Gordon
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001483:Base Sequence; D004247:DNA; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011499:Protein Processing, Post-Translational; D011971:Receptors, Immunologic / Q000502:physiology*; D051116:Receptors, Scavenger
chemical_list: D000911:Antibodies, Monoclonal; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D016173:Macrophage Colony-Stimulating Factor; D004247:DNA