title: Comparison of bolus and constant infusion methods of gadolinium administration in MR angiography.
abstract: OBJECTIVE
  To determine whether the method of delivery of gadolinium can alter optimal small-vessel detail in MR angiography.
  
  
  METHODS
  Six healthy volunteers were studied with MR angiography using both a constant infusion and a bolus method of contrast administration to a total dose of 0.1 mmol/kg. Both three-dimensional time-of-flight and 3-D phase-contrast techniques were used.
  
  
  RESULTS
  Constant infusion did not prove superior to bolus administration of contrast. With both techniques, gadolinium enhancement uniformly improved visualization of small vessels. Delay from the time of contrast administration to scan acquisition decreased vessel enhancement.
  
  
  CONCLUSIONS
  Bolus administration of gadolinium is sufficient to improve small vessel visualization with MR angiography. When a series of contrast-enhanced images is to be obtained, MR angiographic sequences should be obtained first.
authors.affiliation: Yale University School of Medicine, Department of Radiology, New Haven, CT 06510.
authors.forename: G
authors.initials: G
authors.lastname: Sze
authors.forename: S N
authors.initials: SN
authors.lastname: Goldberg
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
mesh_terms: D001921:Brain / Q000098:blood supply*; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA