title: [Bioenergetic mechanisms of the antihypoxic action of mexidol, the succinate-containing derivative of 3-hydroxypyridine].
abstract: The mechanism of antihypoxic action of succinate-containing derivative of 3-hydroxypiridine (mexidol) on hypoxic isolated contractive heart was investigated. By means of inhibitory analysis it was shown that the mechanism is connected with oxidation of succinate in mitochondrial respiratory chain. Activation of succinate oxidase pathway in that situation may be regarded as a immediate compensatory mechanism entering in action at limitation of NADH-oxidase pathway and promoting increase of tissue resistance at oxygen deficiency. Thus, mexidol is antihypoxant of energizing action.
authors.forename: L D
authors.initials: LD
authors.lastname: Luk'ianova
authors.forename: R E
authors.initials: RE
authors.lastname: Atabaeva
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Shepeleva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004579:Electron Transport / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D010847:Picolines / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate
vernacular_title: Bioénergeticheskie mekhanizmy antigipoksicheskogo deĭstviia suktsinatsoderzhashchego proizvodnogo 3-oksipiridina meksidola.