Early effects of GM1 in experimental cerebral focal ischemia in rabbits.
This study aimed to investigate the effects of monosialoganglioside (GM1) when administered early in a model of cerebral focal ischemia, in the rabbit. The statistical evaluation of the electroencephalographic changes (quantified EEG analysis, QEEG) due to the ischemic event showed that the early treatment (1-3-24 h) with GM1 reduced the EEgraphic pattern typical of this model of cerebral ischemia. Considering the observation period, we hypothesized that it was due to the formation of an oedema of a lesser degree compared to the untreated group. Particularly, we did not obtain the increase in delta activity on the contralateral hemisphere, which we thought was expression of the diaschisi phenomenon.
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Istituto Neurologico C. Mondino, Università di Pavia.
Marchioni
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Soragna
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Savoldi
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D000208:Acute Disease; D000818:Animals; D001929:Brain Edema / Q000517:prevention & control; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002462:Cell Membrane / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D005677:G(M1) Ganglioside / Q000494:pharmacology / Q000627:therapeutic use*; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy / Q000503:physiopathology; D008954:Models, Biological; D011817:Rabbits
D005677:G(M1) Ganglioside