[Role of prostaglandins and cyclic nucleotides in the mechanism of development of drug-induced thrombocytopenia].
The experiments on dogs have shown that at the moment of maximal thrombocytopenia, induced by using of 0.7 mg/kg rubomycin intravenous daily during 5 days, there was a sharp increase in cAMP concentration, while the content of prostaglandin E group and F2 alpha in blood decreased. Concentration of cGMP began to increase by the 10th day. We can arrive at the opinion that the rubomycin acts on the receptors of hemopoietic precursor cells' membrane. This causes the activation of adenylate-cyclase, which stimulates the formation of cAMP, causing cells' proliferation depression. This mechanism may be regarded as the restoration reaction of megakaryocyte-thrombocyte system.
Abesadze
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Atanelishvili
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D000262:Adenylyl Cyclases / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D003630:Daunorubicin / Q000494:pharmacology; D004285:Dogs; D004789:Enzyme Activation; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D008533:Megakaryocytes / Q000166:cytology / Q000187:drug effects; D009712:Nucleotides, Cyclic / Q000097:blood / Q000502:physiology*; D011453:Prostaglandins / Q000097:blood / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000503:physiopathology
D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D000262:Adenylyl Cyclases; D003630:Daunorubicin
Rol' prostaglandinov i tsiklicheskikh nukleotidov v mekhanizme razvitiia medikamentoznoĭ trombotsitopenii.