title: [Indications and complications of systemic corticosteroid therapy in treatment of uveitis].
abstract: OBJECTIVE
  Systemic steroids is often the first choice of immunosuppressive therapy for severe endogenous uveitis. The aim of this study was to analyse the indications of steroid therapy, complications and side-effects.
  
  
  METHODS
  Charts from all patients that received oral steroid therapy were reviewed for this purpose and a questionnaire was sent out to all patients to record their subjective complaints.
  
  
  RESULTS
  From January 1990 to March 1993, 63 out of the 435 new patients seen at the uveitis clinic received oral prednisone. In 4 cases severe complications occurred that did however not lead to discontinuation of therapy. In 2 cases of intolerance cyclosporine (CsA) had to be added to the treatment regimen to lower the steroid doses and in one case steroids had to be stopped because of intolerance. The questionnaire showed a high rate of subjective side-effects to steroids.
  
  
  CONCLUSIONS
  In our collective oral steroids were associated with complications, intolerance and side-effects in a high proportion of cases. It is important to explain the possible side-effects to the patient before starting the therapy. The preventable collateral effects like weight gain and decalcification should be addressed by diet recommendations and modern calcium sparing therapy.
authors.affiliation: Service Universitaire d'Ophtalmologie, Hôpital Jules Gonin, Lausanne.
authors.forename: C
authors.initials: C
authors.lastname: Auer
authors.forename: V T
authors.initials: VT
authors.lastname: Tran
authors.forename: Y
authors.initials: Y
authors.lastname: Guex-Crosier
authors.forename: N
authors.initials: N
authors.lastname: Pittet
authors.forename: C P
authors.initials: CP
authors.lastname: Herbort
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D011241:Prednisone
vernacular_title: Indications et complications de la corticothérapie systémique dans le traitement des uvéites.