Is there a link between beta-endorphin and diabetes in pregnancy?
The possible influence of both beta-endorphin and insulin secretion on diabetes development in pregnant women was studied by means of radioimmunoassay technique (RIA-Nichols Institute). The study was carried out by determination of beta endorphins in peripheral blood samples of 28 pregnant women with gestational diabetes. They consisted of two subgroups: 14 women with insulin independence, and 14 with insulin-dependent disease. Beta endorphin increase was found in both groups, according to the progression of gestation, and the rise was significantly higher in the insulin-dependent group. At the same time, insulin application caused a marked growth of beta-endorphins in insulin-dependent group. Beta-endorphins, inhibiting insulin secretion, can influence gestational diabetes development.
Terzić
M
M
Department of Obstetrics and Gynecology, School of Medicine, Belgrade, Yugoslavia.
Stimec
B
B
Sulović
V
V
Plećas
D
D
Vojdović
L J
LJ
D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin