Experimental vitreous replacement with perfluorotri-n-propylamine.
OBJECTIVE
To evaluate perfluorotri-n-propylamine, a perfluorocarbon oil, as a temporary vitreous replacement in rabbits.


METHODS
After undergoing gas compression vitrectomy, rabbits were injected with perfluorotri-n-propylamine for 24 hours or 2 weeks. The rabbits were evaluated clinically and with electroretinography. The globes were then enucleated and processed for histological evaluation.


RESULTS
Clinical results showed droplet dispersion in the 2-week but not in the 24-hour group. Histological evaluation showed no changes in the retinal pigment epithelium or photoreceptor outer segments. Foam cells were seen in the 2-week but not in the 24-hour group. There was a marked dampening of the electroretinographic response that normalized after the removal of the oil.


CONCLUSIONS
Perfluorotri-n-propylamine demonstrated no retinal toxic side effects in rabbits and is a promising liquid perfluorocarbon oil.
Bryan
J S
JS
Department of Ophthalmology, University of Florida College of Medicine, Gainesville.
Friedman
S M
SM
Mames
R N
RN
Margo
C E
CE
D000818:Animals; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D005466:Fluorocarbons; D007267:Injections; D008297:Male; D010786:Photoreceptor Cells / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000473:pathology; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects
D005466:Fluorocarbons; C039422:perfluorotripropylamine