title: A case of the 'dapsone syndrome'.
abstract: The 'dapsone syndrome' developed in a 44-year-old woman who was treated for pyoderma gangrenosum with 100 mg/day dapsone for about 5 weeks. Symptoms included fever, malaise, jaundice with hepatic dysfunction, lymphadenopathy, mononucleosis and dermatitis. These symptoms disappeared with 30 mg/day of oral prednisolone. A lymphocyte stimulation test with dapsone was positive, as was the delayed-type intradermal skin test with 0.5 and 0.05% dapsone in saline. Immunohistochemical studies of the rash and skin test reaction revealed that the dominant infiltrating T cells in the upper dermis were of the Leu 2a+ cytotoxic/suppressor-type rather than the Leu 3a+ helper/delayed hypersensitivity-type.
authors.affiliation: Department of Dermatology, Yokohama City University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: Z
authors.initials: Z
authors.lastname: Ikezawa
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Kim
mesh_terms: D000328:Adult; D003622:Dapsone / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D017511:Pyoderma Gangrenosum / Q000188:drug therapy; D012867:Skin / Q000473:pathology
chemical_list: D003622:Dapsone