Pulsatile gonadotropin releasing hormone (GnRH)--treatment for hypothalamic amenorrhoea causing infertility.
Thirty women with hypothalamic amenorrhoea and infertility were treated with pulsatile GnRH s.c. without monitoring with estradiol and ultrasonography. Ovulation rate per patient was 93%. Ovulation rate per cycle was 90%. Pregnancy rate per ovulatory cycle 30%. Miscarriage rate 18.5%. 23 children were born including one set of twins. No serious side effects were recorded.
Skarin
G
G
Specialist Open-care Unit of Obstetrics and Gynecology, Uppsala, Sweden.
Ahlgren
M
M
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications*; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D010062:Ovulation Induction / Q000379:methods; D011673:Pulsatile Flow; D016896:Treatment Outcome
D007987:Gonadotropin-Releasing Hormone