[Therapy of migraine with special reference to sumatriptan].
A migraine attack results from an inflammatory process of intracranial blood vessels with secondly vasodilation. Sumatriptan activates vascular 5-HT1-receptors to constrict the affected vessels (12, 14) and clinical studies have shown, that it is highly effective in the treatment of migraine and cluster headache. Results from controlled, double-blind studies are discussed, comparing sumatriptan with placebo or standard treatment. Over all it produced faster and greater relief of migraine or cluster headache and was well-tolerated. Advising patients of the risk of side-effects is necessary; it is a safe treatment. Sumatriptan 100 mg tablets or 6 mg in pre-filled syringes for use with autoinjector are available, intranasal administration still needs testing.
Baumhackl
U
U
Neurologischen Abteilung, Krankenhauses der Landeshauptstadt St. Pölten.
D003027:Cluster Headache / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D004347:Drug Interactions; D006801:Humans; D008881:Migraine Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D018170:Sumatriptan / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
D011985:Receptors, Serotonin; D018170:Sumatriptan
Therapie der Migräne mit besonderer Berücksichtigung von Sumatriptan.