[Benzo(a)pyrene induces planocellular metaplasia of the respiratory epithelium in explants of embryonic mouse lung].
The direct effect of benz(a)pyrene (BP) induces squamous epithelial metaplasia (SEM) in organ cultures from embryonic lungs of C57BL and A. The incidence of SEM depend on the doses of BP (3-6-12 mkg/ml), duration of treatment and on the mice line.
Kolesnichenko
T S
TS
Gor'kova
T G
TG
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D008168:Lung / Q000196:embryology / Q000473:pathology*; D008679:Metaplasia / Q000139:chemically induced; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques; D013045:Species Specificity
D001564:Benzo(a)pyrene
Benz(a)piren indutsiruet ploskokletochnuiu metaplaziiu respiratornogo épiteliia v éksplantatakh émbrional'nykh legkikh mysheĭ.