title: The role of apolipoprotein E in the nervous system.
abstract: Human apolipoprotein (apo)E, an important component of plasma lipoprotein metabolism, was recently linked to Alzheimer's disease. Of the three common apoE alleles, epsilon 4 has emerged as a major risk factor. This review summarizes the data leading to this conclusion and discusses possible mechanisms for apoE involvement based on recent biochemical studies.
authors.affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, California.
authors.forename: K H
authors.initials: KH
authors.lastname: Weisgraber
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: W J
authors.initials: WJ
authors.lastname: Strittmatter
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009424:Nervous System Physiological Phenomena; D016875:tau Proteins / Q000378:metabolism
chemical_list: D001057:Apolipoproteins E; D016875:tau Proteins