[Anti-S antibodies in autoimmune hemolytic anemia].
21 year old female with severe symptoms of AIHA developed twice acute haemolytic reactions at the time of blood transfusions compatible in ABO and Rh blood group systems as well as in K antigen, but incompatible by cross-match due to the presence of autoantibody in her serum. High-affinity IgG autoantibody of an unusual anti-S specificity firmly blocked S determinants on the patient red cells. S negative blood was well tolerated. Utero-vaginal infection by human papilloma virus which might have been the cause of AIHA was detected. Long-lasting steroid therapy and specific treatment of infection improved the clinical condition. The patient was under observation for 20 months. Anti-S autoantibody was being detected in the period of 18 months. Then, very weak anti-U autoantibody appeared.
Fabijańska-Mitek
J
J
Kliniki Hematologii Instytutu Hematologii i Transfuzjologii w Warszawie.
Kopeć
I
I
Seyfriedowa
H
H
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D017293:Protein S / Q000276:immunology*
D001323:Autoantibodies; D017293:Protein S
Autoprzeciwciała anty-S w przebiegu niedokrwistości autoimmunohemolitycznej.