[The characteristics of the adaptive behavior, neurological recovery and a morphometric analysis of the cerebral cortex in rats in the postresuscitation period].
Rats recovered after a 10-min circulation arrest, were examined in the early postresuscitation period (within 10-12 days after resuscitation) in an open field (OF) test and during elaboration and reproduction of passive avoidance conditioned reflex (PACR); morphometric analysis of sensorimotor brain cortex was performed on days 4, 7, 14, and 30 after resuscitation. It has been shown that directly after compensation of external neurological deficit which took place in the majority of animals within 3 days the process of adaptation to new situation (OF test) in resuscitated rats, unlike the intact ones, was associated with high motor activity and not with the elaboration of stable correlations between various behavioral acts. At the same time disorders in learning and memory have been observed in PACR test. Morphometric studies have revealed changes in neuroglial relations by day 14 and considerable dystrophic neuronal changes by month 1 after resuscitation. All these disturbances took place with the overall density of neuron population preserved.
Zarzhetskiĭ
Iu V
IuV
Mutuskina
E A
EA
Avrushchenko
M Sh
MSh
Volkov
A V
AV
Gurevich
A M
AM
D000222:Adaptation, Physiological; D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000473:pathology*; D003214:Conditioning, Classical; D003643:Death; D008297:Male; D009420:Nervous System / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology; D051381:Rats; D012151:Resuscitation; D013997:Time Factors
Osobennosti adaptivnogo povedeniia, nevrologicheskoe vosstanovlenie i morfometricheskiĭ analiz kory mozga krys v postreanimatsionnom periode.