A "primitive" catastrophic antiphospholipid syndrome.
A female patient affected by a thrombotic syndrome due to non SLE-related antiphospholipid antibodies (APA), developed a serious, non inflammatory, thrombotic macroangiopathy and uremic-hemolytic syndrome during oral anticoagulant therapy. She was treated with aspirin, dipyridamole i.v. and with a total of 14 fresh frozen plasma exchange (PEX), but the thrombotic syndrome only showed a partial response with the APA titre dropping considerably. Renal failure did not improve because of acute cortical necrosis. The patient died from infective complications.
Vivaldi
P
P
Second Medical Division, St. Chiara General Hospital, Trento, Italy.
Andreotti
C
C
Mazzon
C
C
Pedrazzoli
M
M
D016736:Antiphospholipid Syndrome / Q000150:complications / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D013927:Thrombosis / Q000209:etiology