title: Conservative treatment of early-stage breast cancer. The Emory experience.
abstract: Between January 1983 and December 1991, 80 women with AJCC clinical stage I or II breast cancer were treated with conservative surgery and radiation therapy. Reexcision of the primary was performed in 40 breasts, and residual tumor was identified in 40% of these. Margins of resection were assessed in 80% and, of these, 46 patients had final margins of resection that were negative, 86% had axillary node dissection, 45 patients had histologically negative axillary nodes, and 24 had histologically positive axillary nodes. Of patients with histologically positive lymph nodes, 92% received systemic adjuvant treatment consisting of chemotherapy in 19/24 and tamoxifen in 14/24. Median follow-up was 34 months (range: 6-90 months). The adjusted 5-year actuarial Overall Survival for the group was 92%, and Disease-Free Survival was 80%. The 5-year Local Recurrence-Free Survival was 96%. The present study confirms the excellent results that can be obtained with conservative surgery plus radiation therapy.
authors.affiliation: Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: R G
authors.initials: RG
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Landry
authors.forename: W C
authors.initials: WC
authors.lastname: Wood
authors.forename: T
authors.initials: T
authors.lastname: Styblo
authors.forename: L L
authors.initials: LL
authors.lastname: Hughes
authors.forename: M
authors.initials: M
authors.lastname: Lynn
authors.forename: R M
authors.initials: RM
authors.lastname: York
authors.forename: R W
authors.initials: RW
authors.lastname: Powell
authors.forename: E
authors.initials: E
authors.lastname: Butker
authors.forename: D H
authors.initials: DH
authors.lastname: Lawson
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011379:Prognosis; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D013629:Tamoxifen