title: [Effect of a cisplatin-5-fluorouracil combination chemotherapy on malignant transformation of the epithelium of mouth mucosa].
abstract: In a prospective study we examined the effect of preoperative chemotherapy with cisplatinum and 5-fluorouracil (5-FU) in 40 patients with advanced carcinoma of the oral cavity. Histopathologic grading, cell kinetics and immunohistochemical parameters of the mucosa were determined at two different locations. Prior to therapy, histologic dysplasias in the mucosa "close" to the tumor were observed in 75 percent of the patients. Dysplastic changes of the mucosa "far" from tumor were also found in more than one-third of the patients. Our results show that more advanced dysplasias improve only temporarily under the influence of preoperative systemic chemotherapy. Moreover, new dysplasias appearing during chemotherapy and persisting after its termination are probably induced. The results point to a possible carcinogenic potential of the combined chemotherapy schema used.
authors.affiliation: Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie, Heidelberg.
authors.forename: J
authors.initials: J
authors.lastname: Zöller
authors.forename: H
authors.initials: H
authors.lastname: Maier
authors.forename: M
authors.initials: M
authors.lastname: Flentje
authors.forename: I A
authors.initials: IA
authors.lastname: Born
authors.forename: H
authors.initials: H
authors.lastname: Osswald
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007972:Leukoplakia, Oral / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Der Einfluss einer Cisplatin-5-fluorouracil-Kombinations-chemotherapie auf die maligne Transformation des Epithels der Mundschleimhaut.