Enhanced neoplastic lesion development with adenine-induced experimental multicystic nephropathy by adenine--a model system for the analysis of renal tumor generation in long-term hemodialysis patients.
To cast light on the high incidence of renal cell tumors (RCT) in long-term hemodialysis patients, the role of background multicystic nephropathy was studied in a rat model. Group 1 animals were initially given N-ethyl-N-hydroryethylnitrosamine (EHEN) then subjected to adenine feeding until killing during weeks 20-27. Groups 2 and 3 received EHEN and adenine, respectively. All rats receiving adenine developed multicystic nephropathy. The incidence of renal cell hyperplasias (RCH) and multiplicities of both RCH and RCT in Group 1 were significantly increased as compared with Group 2, suggesting multicystic nephropathy provides favorable environment for tumor development.
Tsuda
H
H
Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
Matsumoto
K
K
Iwase
T
T
Nishida
Y
Y
Baba
H
H
D000225:Adenine; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D004052:Diethylnitrosamine / Q000031:analogs & derivatives; D004848:Epithelium / Q000473:pathology; D006965:Hyperplasia; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D006435:Renal Dialysis / Q000009:adverse effects
C023845:N-ethyl-N-hydroxyethylnitrosamine; D004052:Diethylnitrosamine; D000225:Adenine