Child with Sotos phenotype and a 5:15 translocation.
We report on a 4-year-old girl with Sotos phenotype and a de novo balanced translocation between the long arms of chromosome 5 and chromosome 15 [46,XX,t(5,15)(q35;q22)]. We suggest a relationship between genetic material at 5q35 or 15q22 and the expression of an autosomal dominant gene.
Maroun
C
C
Department of Pediatrics, St. Joseph's Hospital and Medical Center, Paterson, NJ 07503.
Schmerler
S
S
Hutcheon
R G
RG
D000015:Abnormalities, Multiple / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D005145:Face / Q000002:abnormalities*; D005260:Female; D005385:Fingers / Q000002:abnormalities; D005799:Genes, Dominant; D005877:Gigantism / Q000235:genetics*; D006257:Head / Q000002:abnormalities*; D006801:Humans; D007231:Infant, Newborn; D010159:Palate / Q000002:abnormalities; D010641:Phenotype; D011596:Psychomotor Disorders / Q000235:genetics; D013577:Syndrome; D014178:Translocation, Genetic