[Fish oils and rheumatoid arthritis. A randomized and double-blind study].
The effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with active rheumatoid arthritis was evaluated in a multicentre, randomized and double blind study. Fifty-one patients with active rheumatoid arthritis were included from three Danish hospital Departments of Rheumatology. The patients were allocated to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with a fat composition averaging the Danish diet. Small but significant improvements in morning stiffness, joint tenderness and C-reactive protein were observed. There were no serious side-effects. Dietary supplementation with n-3 PUFA in patients with active rheumatoid arthritis has a modest effect on three out of eight disease variables, without effect on other traditional parameters for monitoring disease activity.
Faarvang
K L
KL
Reumatologisk afdeling, Amtssygehuset i Herlev.
Nielsen
G L
GL
Thomsen
B S
BS
Teglbjaerg
K L
KL
Hansen
T M
TM
Lervang
H H
HH
Schmidt
E B
EB
Dyerberg
J
J
Ernst
E
E
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000178:diet therapy*; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D011379:Prognosis; D013997:Time Factors
D015525:Fatty Acids, Omega-3; D005395:Fish Oils
Fiskeolie og reumatoid artrit. En randomiseret og dobbeltblind undersøgelse.