title: Studies on oral transmission of Potomac horse fever.
abstract: Eight normal ponies placed in direct contact with ponies experimentally infected with Ehrlichia risticii for 30 to 90 days did not develop signs of Potomac horse fever. They also did not seroconvert, and they remained susceptible to IV infection. One of 8 ponies that were force fed fresh feces from infected ponies while in direct contact with ponies experimentally infected with E. risticii developed Potomac horse fever and seroconverted. The other 7 remained asymptomatic, did not seroconvert, and were susceptible to IV infection. Six of 9 ponies inoculated with E. risticii via nasogastric intubation and oral drench developed Potomac horse fever and seroconverted. The other 3 remained asymptomatic and did not seroconvert. One of these latter ponies and 2 normal ponies that were inoculated via oral drench only developed Potomac horse fever and seroconverted. The high fever, maximum clinical score for decreased feed intake, depressed mental attitude, decreased borborygmal sounds, severity of diarrhea, and the length of illness of the orally infected ponies was not significantly different from those of IV infected control ponies, although the signs occurred significantly later (P < .05).
authors.affiliation: Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
authors.forename: J E
authors.initials: JE
authors.lastname: Palmer
authors.forename: C E
authors.initials: CE
authors.lastname: Benson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D016470:Bacteremia / Q000662:veterinary; D004536:Ehrlichia / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D016873:Ehrlichiosis / Q000175:diagnosis / Q000635:transmission / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000382:microbiology / Q000635:transmission*; D006736:Horses; D008297:Male
chemical_list: D000907:Antibodies, Bacterial