title: Case report: treatment of an intracranial arteriovenous malformation in a patient with complicated hemophilia.
abstract: The authors describe a young man with hemophilia complicated by chronic hepatic dysfunction, hypodysfibrinogenemia, and immune thrombocytopenia that resulted in a complex coagulopathy. The patient had a ruptured occipital arteriovenous malformation. The malformation was managed by temporary correction of the coagulopathy using cryoprecipitate, platelet transfusions, and plasmapheresis with fresh frozen plasma replacement. The patient underwent staged preoperative embolization followed by surgical excision of the lesion. Hemostasis was acceptable during the neurointerventional and subsequent surgical management, and no complications of coagulopathy occurred. Plasmapheresis may provide effective preparation for patients with hemophilia and complex coagulation abnormalities who require neurosurgical intervention.
authors.affiliation: Department of Neurosurgery, California Pacific Medical Center, San Francisco.
authors.forename: B T
authors.initials: BT
authors.lastname: Andrews
authors.forename: R B
authors.initials: RB
authors.lastname: Stricker
authors.forename: D
authors.initials: D
authors.lastname: Kitt
authors.forename: D K
authors.initials: DK
authors.lastname: Galanakis
authors.forename: L B
authors.initials: LB
authors.lastname: Gerson
authors.forename: G B
authors.initials: GB
authors.lastname: Hieshima
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000150:complications; D001165:Arteriovenous Malformations / Q000150:complications / Q000601:surgery / Q000628:therapy*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000628:therapy; D006259:Craniocerebral Trauma / Q000150:complications; D004621:Embolization, Therapeutic; D005169:Factor VIII / Q000032:analysis / Q000627:therapeutic use; D006408:Hematoma, Subdural / Q000209:etiology / Q000601:surgery / Q000628:therapy; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008866:Microsurgery; D009778:Occipital Lobe / Q000098:blood supply*; D010314:Partial Thromboplastin Time; D010956:Plasmapheresis; D011300:Preoperative Care; D012421:Rupture; D013921:Thrombocytopenia / Q000150:complications*
chemical_list: D005169:Factor VIII