title: [High frequency oscillatory ventilation of infants with severe respiratory disorders: possibilities, risks and limits].
abstract: By pediatricians the high frequency oscillatory ventilation (HFOV) is used almost only in the neonatal period. We report on the administration of HFOV in infants with pulmonary insufficiency after failure of conventional ventilatory support. 6 infants (aged 2-7 months, all former preterm babies) were referred to our hospital due to severe pneumonia after unsuccessful conservative management. Indications for HFOV were hypoxia (mean paO2 41.8 mm Hg with FiO2 = 0.95 and mean airway pressure = 16.6 cm H2O) and/or air leak syndrome. In all cases a sufficient oxygenation could be achieved by HFOV, followed then by stepwise reduction of FiO2 and MAP. The air leaks receded. After 12-178 h on HFOV a successful switchback to conventional ventilatory support (at FiO2 = 0.48 and MAP < 12 cm H2O) was possible, all infants were extubated 6-15 days later. Possible risks of HFOV are air leaks, a necrotizing tracheobronchitis and hemodynamic changes due to compression of the heart and great vessels. With the at the moment in Germany available oscillatory ventilators HFOV as a rescue therapy must be limited for infants with a body weight below 5-6 kg.
authors.affiliation: Kinderklinik und Institut für klinische Radiologie, Universitätsklinikum Mannheim.
authors.forename: V
authors.initials: V
authors.lastname: Varnholt
authors.forename: P
authors.initials: P
authors.lastname: Lasch
authors.forename: W
authors.initials: W
authors.lastname: Kachel
authors.forename: T
authors.initials: T
authors.lastname: Diehm
authors.forename: W
authors.initials: W
authors.lastname: Koelfen
mesh_terms: D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008478:Mediastinal Emphysema / Q000503:physiopathology / Q000628:therapy; D010100:Oxygen / Q000097:blood; D011030:Pneumothorax / Q000503:physiopathology / Q000628:therapy; D011859:Radiography; D012127:Respiratory Distress Syndrome, Newborn / Q000000981:diagnostic imaging / Q000628:therapy*
chemical_list: D010100:Oxygen
vernacular_title: Hochfrequenzoszillationsbeatmung bei Säuglingen mit schwersten Atemstörungen: Möglichkeiten, Risiken und Grenzen.