title: Transcription of the human apolipoprotein A-II is down-regulated by the first intron of its gene.
abstract: Several reports indicate that apoA-II, the second most abundant HDL protein, plays a crucial role in modulating the anti-atherogenic behavior of HDL. Regulatory elements located 5' to the human apoA-II promoter have been previously described. In this paper we report that the first intron of the human apoA-II gene down-regulates its own promoter and the ubiquitous thymidine kinase promoter both in HepG2 and Caco-2 cells. The intron contains three sequences which bind nuclear proteins, thus demonstrating the presence of regulatory elements downstream of the transcription start site of the apoA-II gene.
authors.affiliation: SERLIA, Institut Pasteur de Lille, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Bossu
authors.forename: F L
authors.initials: FL
authors.lastname: Chartier
authors.forename: N
authors.initials: N
authors.lastname: Vu-Dac
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
authors.forename: B
authors.initials: B
authors.lastname: Laine
mesh_terms: D016633:Apolipoprotein A-II / Q000235:genetics*; D001665:Binding Sites; D006528:Carcinoma, Hepatocellular; D003110:Colonic Neoplasms; D003850:Deoxyribonuclease I; D005786:Gene Expression Regulation; D006801:Humans; D007438:Introns; D008113:Liver Neoplasms; D009687:Nuclear Proteins / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013937:Thymidine Kinase / Q000235:genetics; D014158:Transcription, Genetic; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D016633:Apolipoprotein A-II; D009687:Nuclear Proteins; D013937:Thymidine Kinase; D003850:Deoxyribonuclease I