title: Is rice based oral rehydration therapy effective in young infants?
abstract: Rice based oral rehydration therapy (ORT) solutions have been shown to be superior to glucose oral rehydration salts (World Health Organisation (WHO) ORS) in reducing stool volume and duration of diarrhoea in children and adults. Rice based ORT has been used only sparingly in young infants, however, because of theoretical concerns about digestibility. A randomised controlled trial of rice based ORT (50 g rice and electrolytes identical to WHO ORS) and WHO ORS was carried out in 52 male infants less than 6 months old with moderately severe acute diarrhoea to evaluate efficacy and digestibility. Nineteen (70%) of 27 children who received rice based ORT and 18 (72%) of 25 children who received WHO ORS were treated successfully. The mean (SD) diarrhoeal stool output for the first 24 hours of treatment was significantly lower in the infants receiving the rice based ORT than in those receiving WHO ORS (101.0 (60.5) v 137.1 (74.6) g/kg). The stool output was also significantly less in the rice based ORT group in the second 24 hours. Infants in the rice based ORT group drank significantly less rehydration solution than infants in the WHO ORS group (mean (SD) 165.4 (77.4) v 217.9 (86.1) during the first 24 hours of treatment. There was no difference in the duration of diarrhoea between the groups. The volume of breast and formula feeding was similar in the two groups. No difference was seen in the frequency of finding reducing substances or acid pH in the stools of either group of children. The results suggest that rice based ORT is as effective as WHO ORS in infants with moderately severe diarrhoea and that rice based ORT is as well tolerated as WHO ORS in infants.
authors.affiliation: Department of Paediatrics, Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Islam
authors.forename: A M
authors.initials: AM
authors.lastname: Molla
authors.forename: M A
authors.initials: MA
authors.lastname: Ahmed
authors.forename: A
authors.initials: A
authors.lastname: Yameen
authors.forename: R
authors.initials: R
authors.lastname: Thara
authors.forename: A
authors.initials: A
authors.lastname: Molla
authors.forename: Z
authors.initials: Z
authors.lastname: Issani
authors.forename: K
authors.initials: K
authors.lastname: Hendricks
authors.forename: J D
authors.initials: JD
authors.lastname: Snyder
mesh_terms: D002951:Citrates; D019343:Citric Acid; D019327:Copper Sulfate; D003967:Diarrhea / Q000378:metabolism / Q000628:therapy*; D004338:Drug Combinations; D005243:Feces / Q000737:chemistry; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007223:Infant; D008297:Male; D012275:Oryza; D011446:Prospective Studies; D015532:Rehydration Solutions / Q000627:therapeutic use*; D017693:Sodium Bicarbonate
chemical_list: D002951:Citrates; D004338:Drug Combinations; D007202:Indicators and Reagents; D015532:Rehydration Solutions; D019343:Citric Acid; C010892:Clinitest; D017693:Sodium Bicarbonate; D019327:Copper Sulfate