[Study of the antimutagenic properties of Angelica archangelica by the micronucleus test].
The antimutagenic activity Angelica archangelica L. water and alcohol extracts thio-tepa against mutagenicity was investigated by the micronucleus test in mouse bone marrow and peripheral blood cells. The reduction of thio-tepa mutagenic activity was more prominent when the extracts were injected 2-hours before thio-tepa treatment as it could be seen at the simultaneous treatment. The observed reduction of micronucleus frequencies was up to 77%. No genotoxic effects of Angelica extracts had been seen at the concentrations 50-100 mg/kg.
Salikhova
R A
RA
Dulatova
Sh N
ShN
Poroshenko
G G
GG
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D013852:Thiotepa / Q000037:antagonists & inhibitors*
D016587:Antimutagenic Agents; D010936:Plant Extracts; D013852:Thiotepa
Izuchenie antimutagennykh svoĭstv dudnika lekarstvennogo (Angelica archangelica L.) mikroiadernym testom.