A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines.
We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1-based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.
Carroll
R
R
Research Laboratory, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.
Lin
J T
JT
Dacquel
E J
EJ
Mosca
J D
JD
Burke
D S
DS
St Louis
D C
DC
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D005822:Genetic Vectors; D015497:HIV-1 / Q000235:genetics*; D066298:In Vitro Techniques; D014161:Transduction, Genetic; D014779:Virus Replication