title: Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord.
abstract: Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3',5'-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3',5'-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.
authors.affiliation: Department of Restorative Sciences, University of Minnesota Dental School, Minneapolis 55455.
authors.forename: M G
authors.initials: MG
authors.lastname: Garry
authors.forename: J D
authors.initials: JD
authors.lastname: Richardson
authors.forename: K M
authors.initials: KM
authors.lastname: Hargreaves
mesh_terms: D000818:Animals; D002351:Carrageenan; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005528:Foot; D006930:Hyperalgesia / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D007267:Injections; D008161:Lumbosacral Region; D008297:Male; D009333:Neck; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D002351:Carrageenan; D000242:Cyclic AMP; D006152:Cyclic GMP