[Tumor necrosis factor in patients with suppurative-septic complications in terminal states and the possibilities for correcting its production].
The authors review the results of study of tumor necrosis factor (TNF) production by mononuclears in 37 patients recovered after critical conditions of various genesis. Relationships between TNF production, condition severity and complications development have been established. Use of a new correcting agent thymogexin ensured a modulating effect and reduced an excessively high TNF production both in vitro and in patients with pyoseptic complications.
Leshin
A A
AA
Pisarev
V M
VM
Kremlev
S G
SG
Tutel'ian
A V
AV
Lebedev
V V
VV
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D004341:Drug Evaluation; D006470:Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D009104:Multiple Trauma / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D009842:Oligopeptides / Q000627:therapeutic use*; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D012131:Respiratory Insufficiency / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D012151:Resuscitation; D013492:Suppuration / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000096:biosynthesis / Q000187:drug effects
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D014409:Tumor Necrosis Factor-alpha; C080035:thymohexin
Faktor nekroza opukholi u bol'nykh s gnoĭno-septicheskimi oslozhneniiami terminal'nykh sostoianiĭ i vozmozhnosti korrektsii ego produktsii.