Phosphorylation and dephosphorylation of protein in regulating cellular function.
Phosphorylation state of cellular proteins reflects the balance between the activities of protein kinases and phosphoprotein phosphatases. The increase in cellular protein phosphorylation in response to stimuli can be achieved by either activating protein kinases and/or promoting the turnover of the protein phosphatases. This review will summarize current knowledge of the control of phosphorylation and dephosphorylation of protein in cells.
Kurosawa
M
M
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
D000818:Animals; D008322:Mammals; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D015290:Second Messenger Systems
D011506:Proteins; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases