title: [Mossbauer spectroscopy of iron in substantia nigra in Parkinson disease and controls].
abstract: Mössbauer spectroscopy was used to study iron content, its redox state and binding sites in substantia nigra from parkinsonian and control brains. Measurements performed on fresh frozen samples demonstrated the presence of ferric iron only, both in disease and control. We found no difference in the total amount of iron in substantia nigra between the disease and control. Mössbauer spectra observed at 4.1 K in fresh frozen samples were different from those obtained in formalin fixed samples. In the fresh frozen samples only ferritin like iron was observed, whereas in the formalin fixed samples also non-ferritin iron was detected. It seems that in formalin fixed brains, during years, iron is released from ferritin and bound to an iron chelator or formalin.
authors.affiliation: Kliniki Neurologicznej AM, Warszawie.
authors.forename: A
authors.initials: A
authors.lastname: Friedman
authors.forename: E R
authors.initials: ER
authors.lastname: Bauminger
authors.forename: J
authors.initials: J
authors.lastname: Gałazka-Friedman
authors.forename: M
authors.initials: M
authors.lastname: Barcikowska
authors.forename: J
authors.initials: J
authors.lastname: Suwalski
authors.forename: D
authors.initials: D
authors.lastname: Hechel
authors.forename: J
authors.initials: J
authors.lastname: Dymecki
authors.forename: I
authors.initials: I
authors.lastname: Nowik
mesh_terms: D000368:Aged; D001344:Autopsy; D006801:Humans; D007501:Iron / Q000032:analysis*; D008543:Melanins / Q000032:analysis; D010300:Parkinson Disease / Q000503:physiopathology*; D015204:Spectroscopy, Mossbauer; D013378:Substantia Nigra / Q000737:chemistry*
chemical_list: D008543:Melanins; D007501:Iron
vernacular_title: Spektroskopia Mössbauerowska zaelaza istoty czarnej w chorobie Parkinsona i kontroli.