title: Cytotoxic and antimicrobial screening of selected terpenoids from Asteraceae species.
abstract: Twelve pure compounds originally obtained through a systematic chemotaxonomical study with Mexican plants of the Asteraceae, were subjected to a cytotoxic and in vitro antimicrobial screening. Three different cell lines in culture (KB, KB-VI and P388) were used in the cytotoxicity assay, while antimicrobial activity was tested against Gram-positive and Gram-negative bacteria, as well as Candida albicans. Of the twelve terpenoids tested, only taraxasterol showed antimicrobial activity against Staphylococcus aureus. The significant cytotoxic activity exhibited by five sesquiterpene lactones, and the moderate cytotoxicity of an eudesmane, is discussed.
authors.affiliation: Centro de Investigación Biomédica del Sur, IMSS, Morelos, Mexico.
authors.forename: M L
authors.initials: ML
authors.lastname: Villarreal
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
authors.forename: D
authors.initials: D
authors.lastname: Alonso
authors.forename: V
authors.initials: V
authors.lastname: Navarro
authors.forename: P
authors.initials: P
authors.lastname: García
authors.forename: G
authors.initials: G
authors.lastname: Delgado
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity*; D010946:Plants, Medicinal; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts; D013729:Terpenes