[N-methyl-3H]methylphenazepam--a new ligand for benzodiazepine receptors].
The binding of [N-methyl-3H] methylphenazepam with synaptosomal membranes of rat striatum was studied. The affinity of binding sites to this ligand was higher when compared with [3H] diazepam. No changes in maximal binding capacity were found in two groups. GABA and muscimol increased the binding of [3H] diazepam and had no effect on binding of [N-methyl-3H] methylphenazepam. Diazepam and phenazepam competitively decreased the [N-methyl-3H] methylphenazepam binding. The inhibitor activity of phenazepam was higher.
Golovko
A I
AI
Sofronov
G A
GA
Kliuntina
T V
TV
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism* / Q000648:ultrastructure; D003975:Diazepam / Q000378:metabolism; D008297:Male; D009118:Muscimol / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; C088660:N-methylphenazepam; D011963:Receptors, GABA-A; D014316:Tritium; D001569:Benzodiazepines; D009118:Muscimol; C017928:phenazepam; D005680:gamma-Aminobutyric Acid; D003975:Diazepam
[N-metil-3H]metilfenazepam--novyĭ ligand dlia benzodiazepinovykh retseptorov.