Crossed renal ectopia associated with maternal alkaloid cocaine abuse: a case report.
Although cocaine abuse has declined in popularity in the United States, certain groups continue to use the drug at high rates. The teratogenicity of cocaine has been widely investigated in the newborn. We report a case of crossed renal ectopia in a term neonate whose mother practiced alkaloid cocaine abuse in the first trimester of pregnancy. We propose that this anomaly was caused by cocaine's direct pharmacologic effect, leading to vasoconstriction that affected the developing fetal kidney by compromising the blood vessels that supply the organ or by causing hemorrhages and infarctions with fibrosis, causing disruption during a crucial period of morphogenesis.
Lezcano
L
L
Department of Pediatrics, Elmhurst Hospital Center, Mount Sinai School of Medicine, N.Y.
Antia
D E
DE
Sahdev
S
S
Jhaveri
M
M
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000328:Adult; D016578:Crack Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011248:Pregnancy Complications; D019966:Substance-Related Disorders; D016216:Ultrasonography, Prenatal
D016578:Crack Cocaine