Brugia malayi in Mastomys natalensis: influence of immunostimulators on exertion of antifilarial activity of diethylcarbamazine.
The effect of immunopotentiators (Freund's complete adjuvant and CDRI Compound no. 84/201) has been evaluated on exertion of antifilarial activity of diethylcarbamazine (DEC) at different dose levels in Mastomys natalensis experimentally infected with Brugia malayi. DEC alone exhibited dose dependent micro- as well as macrofilarial action. In combination with immunomodulators, activity of DEC was significantly enhanced even at a lower dose level (12.5 mg/kg). However at higher dose level (> 25 mg/kg) of the drug along with immunostimulator the adulticidal activity was significantly reduced. Nevertheless, immunopotentiators themselves displayed certain amount of antifilarial action (34-38% macrofilaricidal).
Tyagi
K
K
Central Drug Research Institute, Lucknow, India.
Murthy
P K
PK
Chatterjee
R K
RK
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D017178:Brugia malayi / Q000187:drug effects / Q000276:immunology; D003131:Combined Modality Therapy; D004049:Diethylcarbamazine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005368:Filariasis / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology / Q000628:therapy*; D005620:Freund's Adjuvant / Q000008:administration & dosage; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage; D008842:Microfilariae / Q000187:drug effects / Q000276:immunology; D009115:Muridae
D000276:Adjuvants, Immunologic; D055666:Lipopeptides; D008074:Lipoproteins; C085680:lipopeptide 84-201; D005620:Freund's Adjuvant; D004049:Diethylcarbamazine