[Pathological study of secondary thymic atrophy caused by steroid hormone in mice].
According to the pathological observations on BALB/c mice after being given steroid hormone, the following results were obtained: secondary thymic atrophy could be observed 24 hours after steroid therapy. The degree of atrophy correlated with the amount of medication and duration of therapy; the weight and pathological changes under light and electron microscope examination almost returned to normal 7 days after the drug was stopped except in individual animals. Our study indicated that secondary atrophy of the thymus can be reversed after elimination of the pathogenic factor.
Lin
J Z
JZ
Capital Institute of Pediatrics, Beijing.
Xiong
J
J
Hu
S S
SS
D000818:Animals; D001284:Atrophy; D003907:Dexamethasone / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology*; D013997:Time Factors
D003907:Dexamethasone