Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.
The role of the protooncogene product p95vav in signal transduction was investigated by characterizing its interactions with proteins that may represent components of a novel signaling pathway. We demonstrate here stable association of p95vav with the heterogeneous ribonucleoprotein K (hnRNP-K), a protein that not only was found to be part of hnRNP particles but has also been implicated in transcriptional regulation of the c-myc gene. Through the PLPPPPPPRG sequence, hnRNP-K specifically interacts with the SH3 domain of p95vav and thus represents a novel SH3 binding protein that may be capable of translating cell surface receptor signals through p95vav activation into regulatory events on the level of gene expression.
Hobert
O
O
Department of Molecular Biology, Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.
Jallal
B
B
Schlessinger
J
J
Ullrich
A
A
D000595:Amino Acid Sequence; D001483:Base Sequence; D018797:Cell Cycle Proteins; D002460:Cell Line; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D006801:Humans; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051567:Proto-Oncogene Proteins c-vav; D012261:Ribonucleoproteins / Q000378:metabolism*; D015398:Signal Transduction
D018797:Cell Cycle Proteins; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D009838:Oligodeoxyribonucleotides; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D012261:Ribonucleoproteins; C496618:VAV1 protein, human; C072074:HNRNPK protein, human