An autoradiographic study of the renewal of mouse bronchiolar epithelium following bromobenzene exposure.
This study discusses mice bronchiolar epithelium following bromobenzene (BrBZ) exposure. Our study shows 3 cell types following BrBZ exposure: Clara cells, ciliated cells, and newly discovered BrBZ-resistant nonciliated cells. Through electron microscopic autoradiography, we were able to show the proliferative ability of BrBZ-resistant nonciliated cells. This finding suggests that BrBZ-resistant nonciliated cells may function as progenitor cells. In addition to discovering this new cell type, our results also demonstrate and confirm the proliferative ability of modified Clara cells.
Ogawa
T
T
Department of Pathology, Yokohama City University School of Medicine, Kanazawa-ku, Japan.
Tsubakihara
M
M
Ichikawa
M
M
Kanisawa
M
M
D000818:Animals; D001345:Autoradiography; D001969:Bromobenzenes / Q000633:toxicity*; D001980:Bronchi / Q000166:cytology* / Q000187:drug effects* / Q000648:ultrastructure; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D003594:Cytoplasmic Granules; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D001969:Bromobenzenes; C032036:bromobenzene