[Allergic myocarditis in clozapine treatment].
Clozapine is a high-dose neuroleptic, which is recommended only for those cases in which patients have failed to respond adequately to standard antipsychotic drugs. This report describes a 45 year old man with ischaemic heart disease who died of cardiogenic shock 11 days after starting treatment with clozapine. Autopsy showed apart from coronary atherosclerosis and interstitial fibrosis a considerable infiltration of eosinophilic granulocytes in the myocardium suggesting myocarditis as the cause of death.
Jensen
V E
VE
Patologisk institut, Arhus Amtssygehus.
Gøtzsche
O
O
D003024:Clozapine / Q000009:adverse effects*; D004562:Electrocardiography; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D009206:Myocardium / Q000473:pathology
D003024:Clozapine
Allergisk myocarditis ved klozapinbehandling.