title: Four quadrant fine needle aspiration cytology for the detection of benign proliferative breast lesions accompanying breast carcinoma.
abstract: Forty-eight patients with breast carcinoma were subjected to four quadrant fine needle aspiration (FNA) cytology examination of the ipsilateral and contralateral breast in an attempt to detect any accompanying benign proliferative lesion. Mastectomy of ipsilateral and open biopsy of contralateral breast provided material for histopathological study. Cytological evidence of epithelial proliferation was found in 8 (16.6%) cases which included atypical lobular hyperplasia (ALH), lobular neoplasia in-situ (LNIS), atypical ductal hyperplasia (ADH), and proliferative disease without atypia (PDWA). In lobular proliferative lesions, cytological smears showed configurations of cells that resembled filled up or expanded lobular units. The cytology was not distinctive enough to distinguish the sub-types of lobular proliferations. Likewise, the presence of ductal alterations could be suggested by cytological study but the distinction of proliferative disease without atypia (PDWA) from atypical ductal hyperplasia (ADH) was not possible on a cytological basis.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
authors.forename: G
authors.initials: G
authors.lastname: Jayaram
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Lamba
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged