Inhibition of rat mitochondrial functions in vivo by 6-OHDA and reserpine.
Reserpine caused a decrease in the state 3, respiratory control ratio (RCR) and ADP/O ratio in frontal cortex, striatum and liver of rats 1 h after drug administration. State 4 respiratory rate was stimulated in frontal cortex and striatum. In the liver, 6-OHDA decreased the ADP/O ratio when both pyruvate/malate and succinate were used as substrates. Reserpine induced changes in the activities of Na+K(+)-ATPase and Mg(2+)-ATPase in frontal cortex and liver 15 min and 4 h after administration of the drug. In the liver only 6-OHDA caused the depression of Mg(2+)-ATPase activity (P < 0.05). Reserpine altered the levels of K+, Na+ and Ca2+ cations in rat frontal cortex and striatum, while 6-OHDA caused a decrease in the amount of Mg2+ in liver (P < 0.05).
Osubor
C C
CC
Department of Biochemistry, University of Benin, Nigeria.
Nwanze
E A
EA
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002412:Cations / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology*; D010101:Oxygen Consumption; D010766:Phosphorylation; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002412:Cations; D012110:Reserpine; D016627:Oxidopamine; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase