Cisplatin-induced peptic ulcers, vagotomy, adrenal and calcium modulation.
Cytochemical and autoradiographic studies in Wistar rats [Crl:(WI)BR] show that cisplatin treatment (9 mg/kg) inhibits the release of acetylcholine from the axonal endings of the stomach smooth muscle resulting in bloating of the stomach and ulceration. Cisplatin also induces corticosteroid release from the adrenal gland stimulating peptic ulceration. Vagotomy helps ameliorate the effect but not eliminate it. Calcium supplementation restores normal neuromuscular function to gastric smooth muscle, thereby eliminating the gastro-intestinal toxicity due to cisplatin.
Aggarwal
S K
SK
Department of Zoology, Michigan State University, East Lansing 48824-1115.
San Antonio
J D
JD
Sokhansanj
A
A
Miller
C
C
D000110:Acetylcholinesterase / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002118:Calcium / Q000502:physiology*; D002395:Catecholamines / Q000097:blood; D002794:Choline / Q000378:metabolism; D002945:Cisplatin / Q000633:toxicity*; D005746:Gastric Emptying / Q000187:drug effects; D006651:Histocytochemistry; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000187:drug effects / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D014628:Vagotomy
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D000110:Acetylcholinesterase; D002794:Choline; D002945:Cisplatin; D002118:Calcium