Effect of prostaglandin E1 on experimental acute hepatic failure in rabbits: prostaglandin E1 prevents the development of multiple-organ failure.
Acute hepatic failure was induced in 50 male rabbits by D-galactosamine HCl (1 g per kg bw), and the effects of prostaglandin E1 on this model were investigated. Twelve hours after the administration of D-galactosamine HCl, a continuous infusion of prostaglandin E1 (2 micrograms.kg-1.h-1 or 20 micrograms.kg-1.h-1) was started. Ten animals in each group were observed until the time of death and mean survival times were compared between the groups. Five animals in each group were used for the determination of regional blood flows and brain water content. After the injections of D-galactosamine HCl, serum aspartate transaminase and alanine transaminase activity rose markedly and prothrombin time was prolonged. The administration of prostaglandin E1 did not affect these levels. However, the survival time in the prostaglandin E1 20 micrograms.kg-1.h-1 group (48.2 +/- 10.4 h) was significantly longer (p < 0.005, p < 0.01) than those in the untreated group (24.9 +/- 5.0 h) and the prostaglandin E1 2 micrograms.kg-1.h-1 group (28.1 +/- 5.8 h). Prostaglandin E1 20 micrograms.kg-1.h-1 inhibited elevations of blood urea nitrogen and creatinine and significantly inhibited the decrease of urine volume and urinary sodium excretion.(ABSTRACT TRUNCATED AT 250 WORDS)
Kikuchi
E
E
3rd Department of Internal Medicine, Nara Medical University, Japan.
Fukui
H
H
Matsumoto
M
M
Tsujita
S
S
Matsumoto
M
M
Matsumura
M
M
Uemura
M
M
Tsujii
T
T
D000527:Alprostadil / Q000627:therapeutic use*; D000818:Animals; D005688:Galactosamine; D006501:Hepatic Encephalopathy / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009102:Multiple Organ Failure / Q000517:prevention & control*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D005688:Galactosamine; D000527:Alprostadil