[Effect of prolonged hemodialysis on secretion of growth hormone in patients with chronic renal insufficiency].
Chronic renal insufficiency is known to be associated with the disturbed secretion of growth hormone. The present study was aimed at investigating the effect of hemodialysis lasting several years on growth hormone secretion. The studied groups consisted of 12 nondialyzed patients with chronic renal insufficiency, 12 patients dialyzed for 1 to 50 months, 12 patients dialyzed for 51 to 100 months, 12 patients dialyzed for over 100 months and 12 healthy subjects. Blood serum concentrations of glucose and growth hormone were determined immediately before (basal level) and after inducing hypoglycemia by intravenous administration of 0.1 unit/kg body weight of crystalline insulin. The following results were obtained: 1. In patients with chronic renal insufficiency basal concentration of growth hormone was significantly elevated as compared to that in healthy people irrespective to the duration of hemodialysis. 2. Basal concentration of growth hormone was significantly higher in dialyzed patients than in nondialyzed patients. In patients dialyzed less than 50 months the basal growth hormone concentration was significantly higher than in the remaining groups of dialyzed patients. 3. In the patients dialyzed over 50 months the increment of growth hormone concentration was significantly lower than that in patients dialyzed less than 50 months and in those nondialyzed. It was concluded that hemodialysis continued for many years in patients with chronic renal insufficiency seems to influence significantly the secretion of growth hormone.
Dolińska-Laskoś
C
C
Oddział Nefrologiczny Wojewódzkiego Szpitala Zespolonego, Kielcach.
Grzeszczak
W
W
Zukowska-Szczechowska
E
E
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D001786:Blood Glucose; D013006:Growth Hormone
Wpływ wieloletniej dializoterapii na wydzielanie somatotropiny u chorych z przewlekła niewydolnościa nerek.