Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family.
The cDNA for ATP1AL1--the fifth member of the human Na,K-/H,K-ATPase gene family--was cloned and sequenced. The deduced primary ATP1AL1 translation product is 1,039 amino acids in length and has Mr of 114,543. The encoded protein has all of the structural features common to known catalytic subunits of P-type membrane ion-transporting ATPases and is equally distant (63-64% of identity) from the Na,K-ATPase isoforms and the gastric H,K-ATPase. The ATP1AL1 encoded protein was proposed to represent a new separate group within the family of human potassium-dependent ion pumps.
Grishin
A V
AV
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Sverdlov
V E
VE
Kostina
M B
MB
Modyanov
N N
NN
D000251:Adenosine Triphosphatases / Q000145:classification* / Q000235:genetics; D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D017506:H(+)-K(+)-Exchanging ATPase / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D006801:Humans; D016623:Ion Pumps / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D011188:Potassium / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012867:Skin / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D014018:Tissue Distribution
D018076:DNA, Complementary; D016623:Ion Pumps; D000251:Adenosine Triphosphatases; C088641:ATP12A protein, human; D017506:H(+)-K(+)-Exchanging ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium