On the antigenic diversity threshold model for AIDS.
In this paper stochastic simulations of a model for AIDS pathogenesis developed by Nowak and coworkers are presented. The results reveal a strong dependency on initial conditions, and the model predicts a nonmonotonic hazard rate for the transition to AIDS. Doubts are raised concerning the significance of the "antigenic diversity threshold," since it only partially characterizes the model dynamics.
Stilianakis
N I
NI
Department of Medical Biometry, University of Tübingen, Germany.
Schenzle
D
D
Dietz
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D000940:Antigenic Variation; D006678:HIV / Q000276:immunology; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D013269:Stochastic Processes; D013997:Time Factors