Doxazosin and 48-hour ambulatory blood pressure monitoring in normotensive subjects.
The effect of long-term doxazosin treatment on normotensive subjects was evaluated by 48-hour ambulatory blood pressure (BP) monitoring (ABPM). Eight normotensive volunteers were given 1 mg of doxazosin per day, and the dose was titrated every week up to 8 mg/day. The 48-hour ABPM, using a noninvasive device, was performed before treatment and during the 4th week of treatment. Doxazosin did not decrease the average 48-hour systolic BP, but diastolic BP decreased slightly (3 mmHg). This slight decrease in 48-hour diastolic BP was observed during the daytime. The 48-hour pulse rate (PR) was clearly elevated by doxazosin, which was attributed to tachycardia at night. Thus, the present study using 48-hour ABPM indicated that long-term doxazosin treatment may result in only slight daytime hypotension with apparent nighttime tachycardia in normotensive subjects.
Takata
Y
Y
First Division of Internal Medicine, National Fukuoka Central Hospital, Japan.
Yoshizumi
T
T
Ito
Y
Y
Hirota
Y
Y
Fujishima
M
M
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D015924:Blood Pressure Monitors; D003971:Diastole; D017292:Doxazosin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects
D000959:Antihypertensive Agents; D017292:Doxazosin