Imaging endogenous dopamine competition with [11C]raclopride in the human brain.
This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [11C]raclopride, a D2 receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [11C]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate-induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior.
Volkow
N D
ND
Medical Department, Brookhaven National Laboratory, Upton, NY 11973.
Wang
G J
GJ
Fowler
J S
JS
Logan
J
J
Schlyer
D
D
Hitzemann
R
R
Lieberman
J
J
Angrist
B
B
Pappas
N
N
MacGregor
R
R
D000328:Adult; D000339:Affect / Q000502:physiology; D001007:Anxiety / Q000378:metabolism; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000378:metabolism; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D065127:Dopamine D2 Receptor Antagonists; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000493:pharmacokinetics / Q000494:pharmacology; D008875:Middle Aged; D017072:Neostriatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D020891:Raclopride; D012457:Salicylamides / Q000493:pharmacokinetics*; D013569:Synapses / Q000378:metabolism; D014055:Tomography, Emission-Computed
D065127:Dopamine D2 Receptor Antagonists; D012457:Salicylamides; D008774:Methylphenidate; D020891:Raclopride; D004298:Dopamine