Calcium is necessary in the cell response to EM fields.
Previous research showed that exposure of human HL-60 cells to extremely low frequency electromagnetic fields increases the steady-state levels of some mRNAs. Modifications in calcium flux have been suggested as a means of amplifying electromagnetic signals, and induced changes in calcium influx could hypothetically lead to gene activation. The present experiments tested the role of calcium in the response of cells to electromagnetic fields. Steady state transcript levels for c-fos and c-myc were determined under conditions of low extracellular calcium. The present study confirms that calcium plays a role in the response of cells to electromagnetic fields.
Karabakhtsian
R
R
Department of Biological Sciences, Hunter College, New York, NY.
Broude
N
N
Shalts
N
N
Kochlatyi
S
S
Goodman
R
R
Henderson
A S
AS
D001483:Base Sequence; D002118:Calcium / Q000378:metabolism*; D004574:Electromagnetic Fields; D005786:Gene Expression Regulation; D016762:Genes, fos / Q000235:genetics; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D015398:Signal Transduction; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D002118:Calcium