Influence of diazinon and deltamethrin on reproductive organs and fertility of male rats.
The effect of diazinon and deltamethrine at two dosage levels on male reproductive tissues was studied. The tested doses were given orally to male rats for 65 consecutive days. Sex organs weight analysis, semen picture, testosterone levels and the conception rate were the criteria used to evaluate the productive efficiency of the treated rats. Both doses of diazinon and deltamethrine decreased the weights of most genital organs and motility associated with an increase in the percentage of dead and morphologically abnormal spermatozoa of treated rats. A decrease in the plasma testosterone level was observed in all treated groups. Oral administration of diazinon and deltamethrine for 65 consecutive days decreased the conception rate in non-treated females (mated with treated male).
Abd el-Aziz
M I
MI
Pharmacology Department, College of Vet. Med. (Kafr El-Sheikh) Tanta University, Cairo, Egypt.
Sahlab
A M
AM
Abd el-Khalik
M
M
D000284:Administration, Oral; D000818:Animals; D003976:Diazinon / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005837:Genitalia, Male / Q000187:drug effects*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D003976:Diazinon