[Analysis of changes in concentration of glycosylated hemoglobin and fructosamine during the first three weeks of treatment of children with newly diagnosed insulin-dependent diabetes].
Blood serum fructosamine and blood glycosylated hemoglobin (HbA1) concentrations were determined in 47 children with newly diagnosed insulin-dependent diabetes during their first stay in the hospital. Three determinations at week's intervals were carried out in each patient. The mean values of concentration decrement after the first, second and third week of treatment were 0.47, 0.37 and 0.26 mmol/l, respectively, (median values 0.56, 0.33 and 0.17 mmol/l) for fructosamine concentration, and 1.8, 2.9 and 1.0% (median 1.5, 2.3 and 0.8%) for HbA1. No correlation was found between the weekly decrement values in fructosamine and HbA1 concentrations when all the values were taken into consideration, and only a slight positive correlation when the decrement after two weeks of treatment was considered (r = 0.57, p < 0.05). Very high rate of decrease in the concentration of glycosylated hemoglobin was noted in some children, reaching the values from 4 to even 8.6% per week.
Adamczyk
A
A
Zakład Biochemii Klinicznej, Polsko-Amerykańskiego Instytutu Pediatrii CM UJ, Krakowie.
Ciechanowska
M
M
Dziatkowiak
H
H
Szafran
Z
Z
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000628:therapy; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006595:Hexosamines / Q000378:metabolism*; D006801:Humans; D008297:Male
D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines
Analiza zmian stezenia hemoglobiny glikozylowanej i fruktozaminy w okresie trzech pierwszych tygodni leczenia dzieci ze świezo rozpoznana cukrzyca insulinozalezna.