title: Sequence of the penicillin-binding protein 2-encoding gene (penA) of Neisseria perflava/sicca.
abstract: The nucleotide sequence of the transpeptidase domain (Tp) of the penicillin (Pn)-binding protein 2-encoding gene (penA) from two Pn-sensitive (PnS) and two Pn-resistant (PnR) strains of Neisseria perflava/sicca, has been determined. The sequences from PnS strains, although displaying high homology with those PnS strains from other Neisseria species, also showed several interesting modifications suggesting that these isolates might represent intermediates in the mutational development of PnR in N. perflava/sicca.
authors.affiliation: Servicio de Bacteriologia, CNMVIS, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Perez-Castillo
authors.forename: A M
authors.initials: AM
authors.lastname: Perez-Castillo
authors.forename: J A
authors.initials: JA
authors.lastname: Saez-Nieto
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D001483:Base Sequence; D002352:Carrier Proteins; D005798:Genes, Bacterial; D006602:Hexosyltransferases / Q000235:genetics*; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics*; D002267:Muramoylpentapeptide Carboxypeptidase; D009343:Neisseria / Q000235:genetics*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D009097:Multienzyme Complexes; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase