title: Treatment of stage III non-small cell lung cancer with thoracic radiation therapy and simultaneous platinum chemotherapy.
abstract: Preclinical trials have shown platinum compounds to enhance radiation, and clinical trials that tested simultaneous cisplatin and radiation in a variety of tumors have demonstrated acceptable toxicity. Subsequent reports described the use of platinum chemotherapy and concurrent thoracic radiation therapy for the treatment of locally advanced non-small cell lung cancer. In patients whose disease was considered unresectable, investigators have tested cisplatin primarily as a single agent. Phase III trials compared single-agent cisplatin and simultaneous radiation with radiation alone. Selected phase II trials studied cisplatin, or carboplatin and radiation. Two phase II trials evaluated cisplatin-containing combination chemotherapy and simultaneous split-course radiation therapy in nonsurgical patients. In contrast to nonsurgical trials, studies of preoperative treatment have tested cisplatin-containing combination chemotherapy regimens and simultaneous radiation. Of particular interest are the implications of these studies for future phase III trials.
authors.affiliation: Section of Medical Oncology, Rush University Medical Center, Chicago, IL 60612.
authors.forename: P
authors.initials: P
authors.lastname: Bonomi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D017671:Platinum Compounds / Q000008:administration & dosage
chemical_list: D017671:Platinum Compounds; D002945:Cisplatin