[Radiological and histological studies on the spinal deformity in hereditary lordoscoliotic rabbits].
The author reports his radiological and histological studies to investigate the etiology of spinal deformities in the Lordoscoliotic Rabbit (LSR), which develops thoracic lordosis or lordoscoliosis during growth. The deformities appeared at 4-6 weeks of age and developed until 16 weeks. Most of them demonstrated lordosis, which was generally seen at the T7-10 levels (44 degrees measured by Cobb's method at maximum), and was often accompanied by slight scoliosis (40 degrees at maximum). Histopathological studies clearly indicated that continuous exposure to non-physiological forces caused a deviation in the nucleus pulposus in the disc, and an extension or compression in the annulus fibrosus, followed by a disproportionate growth of the vertebral body. Histological studies of the vertebral bones showed a specific mode of remodeling in response to the force producing lordosis, and suggested that the force producing lordosis played a major role in the pathogenesis of scoliosis in LSR. These results accord with the recent hypothesis that a reduction in kyphosis or a development of lordosis in the thoracic spine is a responsible factor for human idiopathic scoliosis.
Kin
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Department of Orthopedic Surgery, Osaka Medical College.
D000818:Animals; D006801:Humans; D008141:Lordosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D011817:Rabbits; D011859:Radiography; D012600:Scoliosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology