[The action of reserpine in experimental rabies infection].
Experimental studies in laboratory animals showed reserpine in doses of 0.01-0.05 mg/kg body weight to inhibit the development of rabies infection in white mice and rabbits by 40.0-83.4% depending on the dose and mode of administration. The inhibiting properties of reserpine were demonstrated for both fixed and street rabies virus strains. The protective effect of the drug was manifested after parenteral and oral administration to the infected animals. The experimental data suggest that reserpine may be used as an antiviral drug for protective treatment of rabies in the incubation period.
Zubovich
I K
IK
Mishaeva
N P
NP
Votiakov
V I
VI
Kovalev
N A
NA
Shashen'ko
A S
AS
Golovneva
G P
GP
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007273:Injections, Intramuscular; D051379:Mice; D011817:Rabbits; D011818:Rabies / Q000188:drug therapy* / Q000401:mortality; D012110:Reserpine / Q000008:administration & dosage*; D013997:Time Factors
D012110:Reserpine
Izuchenie deĭstviia rezerpina pri éksperimental'noĭ rabicheskoĭ infektsii.