title: Monoamine metabolites in the cerebrospinal fluid in infantile spinal muscular atrophy.
abstract: Analyses of tryptophan and tyrosine metabolites in cerebrospinal fluid were performed to examine an abnormality of the monoamine neurone system in severe infantile spinal muscular atrophy (SMA type I). The levels of 5-hydroxyindoleacetic acid and homovanillic acid were significantly lower than those in controls. Decreases in the concentration of 5-hydroxyindoleacetic acid and kynurenine seemed to be related to the severity of SMA type I. These results suggest that the monoamine neurone system may play a role in the pathophysiology of SMA type I.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Kawase
authors.forename: A
authors.initials: A
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014897:Spinal Muscular Atrophies of Childhood / Q000134:cerebrospinal fluid*; D014364:Tryptophan / Q000134:cerebrospinal fluid; D014443:Tyrosine / Q000134:cerebrospinal fluid
chemical_list: D015306:Biogenic Monoamines; D014443:Tyrosine; D014364:Tryptophan