[Mental deterioration and hypertension: uncommon manifestation of corticotropin insufficiency and functional carboxymethyl oxidase block].
We report a new case of muscle contractures associated with adrenocortical deficiency. Outstanding features were the diffusion of the contractures, rhabdomyolysis and an encephalopathy which disappeared with hormonal therapy. Endocrinological investigations revealed a functional carboxymethyl oxidase type II defect which could, in part, explain our patient's neuromuscular symptoms.
Lifermann
F
F
Service de médecine interne, hôpital Saint-André, Bordeaux, France.
Ellie
E
E
Tabarin
A
A
Julien
J
J
Roger
P
P
D000009:Abdominal Muscles; D000309:Adrenal Insufficiency / Q000150:complications*; D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D001927:Brain Diseases / Q000209:etiology; D003286:Contracture / Q000209:etiology; D019405:Cytochrome P-450 CYP11B2; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D008875:Middle Aged; D008901:Mineralocorticoids / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009122:Muscle Hypertonia / Q000209:etiology*; D012206:Rhabdomyolysis / Q000209:etiology
D008901:Mineralocorticoids; D000324:Adrenocorticotropic Hormone; D006899:Mixed Function Oxygenases; D019405:Cytochrome P-450 CYP11B2; C025352:corticosterone methyl oxidase II
Détérioration intellectuelle et hypertonie: révélation inhabituelle d'une insuffisance corticotrope et d'un bloc fonctionnel en carboxyméthyl oxydase.