[Effect of physical exertion on levels of vasopressin (AVP) and plasma renin activity in patients with chronic kidney failure].
In uraemic subjects many endocrine abnormalities were observed. Plasma vasopressin (AVP) levels and plasma renin activity (PRA) were significantly higher than in normals, but little is known about their vasoregulatory effects during exercise. The aim of our study was to find the answer on the following question: 1.were any significant changes in AVP and PRA levels during exercise in uremic patients and in normals occurred, 2.were any hormonal profile differences between nonhaemodialysed and haemodialysed patients existed, 3.does the correlation between blood pressure changes and AVP and PRA exist. Plasma AVP and PRA levels were measured in 12 uraemic non-haemodialysed subjects, in 12 uraemic haemodialysed subjects and in 12 healthy subjects. In all groups AVP and PRA were examined two times--first in normal conditions (rest) and second time after submaximal work load during ECG exercise test with continuous blood pressure monitoring. In nonhaemodialysed subjects METs value were significantly lower than in other groups. Mean increase of mean blood pressure was comparable between observed groups. We didn't find any significant correlation between changes in plasma AVP and PRA level and other measured parameters.


CONCLUSIONS
1. Exercise test induced qualitatively the same but quantitatively different changes in plasma AVP and PRA concentrations in uraemic and healthy subjects. 2.No significant differences in basal conditions as well as after exercise in plasma AVP and PRA between nonhaemodialysed and haemodialysed patients were observed. 3.No significant correlation between blood pressure and hormonal changes was found.
Burak
W
W
Katedry i Kliniki, Chorób Wewnetrznych i Zawodowych Slaskiej Akademii Medycznej, Zabrzu.
Grzeszczak
W
W
Zukowska-Szczechowska
E
E
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood*; D005080:Exercise Test; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D005082:Physical Exertion / Q000502:physiology*; D006435:Renal Dialysis; D012083:Renin / Q000097:blood*
D001127:Arginine Vasopressin; D012083:Renin
Wpływ wysiłku fizycznego na stezenie wazopresyny (AVP) oraz aktywność reninowa osocza u chorych z przewlekła niewydolnościa nerek.