[The protective properties of the lysosomal form of Pseudomonas aeruginosa anatoxin in a test of its active protection of experimental animals].
The protective activity of the liposomal form of P. aeruginosa toxoid and intact phosphatidylethanolamine liposomes has been evaluated in mice with experimental P. aeruginosa infection. It has been revealed that the liposomal form of P. aeruginosa toxoid, introduced in a single injection, ensures the formation of more intense and prolonged immunity in comparison with that induced by the toxoid adsorbed on aluminum hydroxide. This investigation has revealed that intact phosphatidylethanolamine liposomes also possess protective properties, protecting 10-36.7% of the animals from infection with P. aeruginosa toxigenic strain.
Minukhin
V V
VV
Brodinova
N S
NS
Mikhaĭlova
N A
NA
Ivanova
N N
NN
Tsyganenko
A Ia
AIa
Vasil'chenko
V N
VN
D000818:Animals; D016009:Chi-Square Distribution; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D008081:Liposomes; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000401:mortality / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013997:Time Factors; D014121:Toxoids / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination
D004337:Drug Carriers; D008081:Liposomes; D014121:Toxoids
Izuchenie protektivnykh svoĭstv liposomal'noĭ formy anatoksina Pseudomonas aeruginosa v teste aktivnoĭ zashchity éksperimental'nykh zhivotnykh.