title: Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice.
abstract: Magnesium chloride (MgCl2.6H2O) was administered at dietary levels of 0 (control), 0.3, 0.6, 1.25, 2.5 or 5% to groups of 10 male and 10 female B6C3F1 mice for 13 weeks. In both sexes of the 5% treatment group a decrease in body weight was observed. While clinical signs and hematological or blood biochemistry parameters showed no treatment-related effects, histopathologically, vacuolation of kidney tubular cells was apparent in males of the 2.5 and 5% concentration groups. Thus, the study demonstrated that diet containing over 2.5% MgCl2.6H2O exerts toxic effects in B6C3F1 mice. We therefore conclude that a 2.5% level of MgCl2.6H2O in the diet is the minimal toxic dose.
authors.affiliation: First Department of Pathology, Nagoya City University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Kurata
authors.forename: T
authors.initials: T
authors.lastname: Ogiso
authors.forename: M
authors.initials: M
authors.lastname: Futakuchi
authors.forename: N
authors.initials: N
authors.lastname: Ito
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D015636:Magnesium Chloride / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D005503:Food Additives; D015636:Magnesium Chloride