A neuropathological study of a case of lupus erythematosus with chorea.
Neuropathological examination in a 48-year-women of SLE with chorea was performed. Histological examination of the putamen showed a widespread neuronal loss associated with reactive astrocyte proliferation and neuropil rarefaction at both sides. Disappearance of large neurons was more prominent than that of small ones. Although a few old and fresh microinfarcts were scattered in the same area, there was no significant pathological abnormality in small vessels. The caudate nuclei also showed a few irregular microinfarcts and spotty loss of neurons associated with reactive astrocytosis. These neuropathological changes might be related to the appearance of choreatic movement in patients with SLE.
Kuroe
K
K
First Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.
Kurahashi
K
K
Nakano
I
I
Morimatsu
Y
Y
Takemori
H
H
D001253:Astrocytes / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D002455:Cell Division; D002531:Cerebellum / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D011699:Putamen / Q000473:pathology