Long-term follow-up of mitomycin C nephropathy.
Two cases of mitomycin C nephropathy, which occurred after postoperative chemotherapy for advanced gastric cancer, were followed up for 6 (case 1) and 10 years (case 2). Hemolytic uremic syndrome developed 68 days (case 1) and 160 days (case 2) after the last administration of MMC with a total dose of 60 mg (case 1) and 40 mg (case 2). Serum creatinine levels were normalized in case 1 and they remained at about 2 mg/dl in case 2. Hyporeninemic hypoaldosteronism was transiently seen in case 2. These data suggest that recovery from the acute phase of hemolytic uremic syndrome leads to a good long-term prognosis in MMC nephropathy.
Motoo
Y
Y
Department of Internal Medicine, Kanazawa University.
Sawabu
N
N
Ikeda
K
K
Takemori
Y
Y
Ohta
H
H
Okai
T
T
Yokoyama
H
H
D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006994:Hypoaldosteronism / Q000097:blood / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*; D011379:Prognosis; D012083:Renin / Q000097:blood / Q000172:deficiency; D013274:Stomach Neoplasms / Q000188:drug therapy; D013997:Time Factors
D016685:Mitomycin; D012083:Renin