title: Self-diffusion in CNS tissue by volume-selective proton NMR.
abstract: We have used a volume-selective NMR pulse sequence to measure the diffusion coefficient (D) inside a selected cuboid volume. The sequence is a variant of the stimulated echo method for volume-selective spectroscopy, and allows sequential measurement of D in any of three orthogonal directions and for a range of diffusion times. The echo attenuation from which D is calculated is free from the cross terms that can arise because of interactions between volume selection and diffusion-sensitizing gradients. Anisotropic and diffusion-time-dependent behavior is observed in brain structures known to have axon fibers aligned primarily in one direction.
authors.affiliation: Institute of Neurology, Queen Square, London, U.K.
authors.forename: M A
authors.initials: MA
authors.lastname: Horsfield
authors.forename: G J
authors.initials: GJ
authors.lastname: Barker
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
mesh_terms: D001369:Axons / Q000378:metabolism / Q000648:ultrastructure; D001831:Body Temperature; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D001933:Brain Stem / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000378:metabolism; D002712:Chlorides / Q000737:chemistry; D003337:Corpus Callosum / Q000378:metabolism; D004058:Diffusion; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D017895:Manganese Compounds / Q000737:chemistry; D008961:Models, Structural; D011522:Protons
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; D011522:Protons; C025340:manganese chloride