title: Isolation of a novel RXR from Xenopus that most closely resembles mammalian RXR beta and is expressed throughout early development.
abstract: In a search for nuclear receptors that may mediate the teratogenic effects of the potential morphogen, retinoic acid, on the early development of Xenopus we have isolated a novel Xenopus RXR that most closely resembles the mammalian beta-type RXR. Xenopus RXR beta mRNA is expressed throughout early embryogenesis, and functions as an accessory protein to enhance the DNA-binding of other members of the nuclear receptor superfamily.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry, UK.
authors.forename: S
authors.initials: S
authors.lastname: Marklew
authors.forename: D P
authors.initials: DP
authors.lastname: Smith
authors.forename: C S
authors.initials: CS
authors.lastname: Mason
authors.forename: R W
authors.initials: RW
authors.lastname: Old
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000502:physiology; D005314:Embryonic and Fetal Development; D006801:Humans; D008322:Mammals; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000187:drug effects; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D017386:Sequence Homology, Amino Acid; D013723:Teratogens / Q000633:toxicity; D014157:Transcription Factors; D014212:Tretinoin / Q000633:toxicity; D014982:Xenopus laevis
chemical_list: D009838:Oligodeoxyribonucleotides; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D013723:Teratogens; D014157:Transcription Factors; D014212:Tretinoin