Olfactory neurones expressing distinct odorant receptor subtypes are spatially segregated in the nasal neuroepithelium.
In situ hybridization techniques have been employed to explore the olfactory epithelium of the rat for the distribution of odorant receptor gene transcripts. We demonstrate that olfactory neurone subpopulations expressing distinct receptor subtypes are spatially segregated within the olfactory epithelium. A compartmentalization of the neuroepithelium into distinct expression zone is apparent, cells expressing a specific receptor are randomly distributed within a given zone. Structurally related receptor subtypes share a common distribution pattern.
Strotmann
J
J
University Stuttgart-Hohenheim, Institute of Zoophysiology, Germany.
Wanner
I
I
Helfrich
T
T
Beck
A
A
Meinken
C
C
Kubick
S
S
Breer
H
H
D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D017403:In Situ Hybridization; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000378:metabolism*; D015347:RNA Probes; D016372:RNA, Antisense / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018035:Receptors, Odorant / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution
D015347:RNA Probes; D016372:RNA, Antisense; D012333:RNA, Messenger; D018035:Receptors, Odorant