title: The influence of transurethral resection of prostate on prognosis of patients with adenocarcinoma of the prostate treated by radical radiotherapy.
abstract: Results of 999 patients with carcinoma of the prostate treated with radical radiotherapy were evaluated to assess the impact of pre-treatment transurethral resection of the prostate. (TURP). A total of 427 patients had a needle biopsy and 541 patients had a TURP. In 31 patients the diagnostic procedure could not be ascertained. In patients with stage T1/T2 disease (411) no adverse effect on prognosis was observed following TURP compared with needle biopsy. In patients with stage T3/T4 disease (534) a significantly higher distant relapse rate and cause-specific mortality were observed after TURP but overall survival was similar after TURP and needle biopsy. A significant correlation was observed between the probability of TURP and poorly differentiated cancers. Multivariate analysis which evaluated the influence of age, T stage, histologic differentiation and TURP did not demonstrate diagnostic TURP to be a significant independent prognostic variate for patients with prostate cancer managed by radical radiotherapy.
authors.affiliation: Department of Clinical Oncology, University of Edinburgh, Western General Hospital, UK.
authors.forename: W
authors.initials: W
authors.lastname: Duncan
authors.forename: C N
authors.initials: CN
authors.lastname: Catton
authors.forename: P
authors.initials: P
authors.lastname: Warde
authors.forename: M K
authors.initials: MK
authors.lastname: Gospodarowicz
authors.forename: A J
authors.initials: AJ
authors.lastname: Munro
authors.forename: R
authors.initials: R
authors.lastname: Lakier
authors.forename: J
authors.initials: J
authors.lastname: Simm
authors.forename: T
authors.initials: T
authors.lastname: Panzarella
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D011468:Prostatectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D011882:Radiotherapy, High-Energy; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors