title: Gastric intramural pH as indicator of early allograft viability in orthotopic liver transplantation.
abstract: The determination of the viability of OLT grafts has relied upon metabolic tests of the liver, which take several hours to evaluate and therefore are only conclusive in most patients well into the postoperative period. Earlier diagnosis of graft failure or nonfunction would allow intraoperative reassessment of surgical technique and, in the case of graft failure, earlier planning for retransplantation. Since gastrointestinal mucosal ischemia is one of the earliest manifestations of impaired core tissue in the critically ill, a tonometric nasogastric tube (Tonomitor) was used in our patients to measure intramucosal gastric pH (pHi) during the preanhepatic (stage I), anhepatic (stage II), and neohepatic (stage III) phases of OLT in 35 patients as an indicator of graft liver function and viability. Based on the results of the pHi measurement 30 min after reperfusion during stage III, patients were divided into 2 groups using a pHi of 7.30 as the dividing point. Patients with a pHi equal or higher than 7.30 were assigned to group 1 (n = 24) and patients with a pHi lower than 7.30 were assigned to group 2 (n = 11). The pHi in group 1 patients averaged 7.37 +/- 0.5 30 min after reperfusion and throughout surgery. The pHi in group 2 patients was lower than that of the group 1 patients 30 min after reperfusion, 7.23 +/- 0.04 (P < 0.001). The pHi in 10 group 2 patients returned to normal within 3 hr after reperfusion and the pHi values for these patients were not significantly different from those of group 1 at 3 hr after reperfusion. The pHi in 1 group 2 patient remained lower than 7.30 and never returned to normal; this patient underwent retransplantation the following day. Utilizing the tonometric nasogastric tube to sample intramucosal pH allowed early detection of graft function and intermittent trending of pHi in patients with questionable graft function during the operative period. It also provided a means of assessing graft function independent of enzymatic criteria, which provide little information in the early phase of transplantation.
authors.affiliation: Department of Anesthesiology, University of Alabama at Birmingham 35233-6810.
authors.forename: L
authors.initials: L
authors.lastname: Frenette
authors.forename: D D
authors.initials: DD
authors.lastname: Doblar
authors.forename: D
authors.initials: D
authors.lastname: Singer
authors.forename: J
authors.initials: J
authors.lastname: Cox
authors.forename: J
authors.initials: J
authors.lastname: Ronderos
authors.forename: S
authors.initials: S
authors.lastname: Poplawski
authors.forename: D
authors.initials: D
authors.lastname: Ranjan
mesh_terms: D000328:Adult; D004909:Erythrocyte Indices; D005753:Gastric Mucosa / Q000737:chemistry*; D006084:Graft Rejection / Q000175:diagnosis; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000276:immunology*; D008875:Middle Aged; D013997:Time Factors