Therapeutic efficacy and toxicity of sequential methotrexate and 5-fluorouracil in gastric cancer.
The therapeutic efficacy and toxicity of sequential methotrexate and 5-fluorouracil in 64 inoperable gastric cancer patients are reported. An intermediate-dose treatment was given to 48 patients, and a low-dose treatment to 16 patients. In the intermediate-dose treatment, leukopenia was observed in 11 patients, nausea and vomiting in six patients and diarrhea and stomatitis in two patients each. In the low-dose treatment, no patient developed toxic symptoms of grade 3 or 4. All 9 responders had adenocarcinoma of the poorly differentiated type and the response rate in patients who belonged to this type was 32.1%.
Konishi
T
T
Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
Hiraishi
M
M
Mafune
K
K
Miyama
T
T
Hirata
T
T
Mori
K
K
Nishina
H
H
Idezuki
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D013937:Thymidine Kinase / Q000378:metabolism
D013937:Thymidine Kinase; D005472:Fluorouracil; D008727:Methotrexate