Myoglobinuria following the use of succinylcholine.
Eight hours following tympanoplasty performed under general anaesthesia (sodium pentothal and trichloroethylene), a 30 year old male complained of muscular weakness and dark coloured urine. Urinalysis revealed myoglobin pigment. A rise in BUN (47mg%), serum creatinine (5.7mg%), creatinine phosphokinase (15,500 U/L) and CPK-MB fraction (4690 U/L) was noticed 36 hrs later. The patient developed acute renal failure, and recovered after haemodialysis. From a history of use of succinylcholine as a muscle relaxant during operation, myoglobinuria appears to be secondary to muscle damage caused by succinylcholine.
Bhave
C G
CG
Gadre
K C
KC
Gharpure
B S
BS
D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000768:Anesthesia, General; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D009212:Myoglobinuria / Q000139:chemically induced*; D010035:Otitis Media, Suppurative / Q000601:surgery*; D011183:Postoperative Complications / Q000139:chemically induced*; D013390:Succinylcholine / Q000008:administration & dosage / Q000009:adverse effects*; D014433:Tympanoplasty
D013390:Succinylcholine