title: Smooth tubular aggregates associated with plasmalemmal invagination in alveolar soft part sarcoma.
abstract: The ultrastructure of four alveolar soft part sarcomas was examined to search for ultrastructural signs of myogenic or neural origin. A new ultrastructural structure, an unusual tubular structure, was found in two of four cases. The structure appeared as a large, smooth, tubular aggregate in the cytoplasm of some tumor cells but did not show a honeycomb arrangement of tubules. The aggregate was composed of long, serpentine, branching, smooth, irregularly arranged tubules without ribosomes that ran in various directions. The aggregates intermingled with small amounts of cytoplasmic organelles. Because the aggregated tubules were at times continuous with cell membranes, it was shown that they were the complex extensions or invaginations of cell membranes. Neither myelin-axon complexes nor myofilaments, including Z band material, were seen in any case. There was a possibility that the smooth tubular aggregate was a T-tubule-like structure, suggesting that the tumors were derived from skeletal muscle cells.
authors.affiliation: Department of Orthopedic Surgery, Teikyo University School of Medicine, Ichihara, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: P
authors.initials: P
authors.lastname: Park
authors.forename: S
authors.initials: S
authors.lastname: Higaki
authors.forename: H
authors.initials: H
authors.lastname: Miki
authors.forename: S
authors.initials: S
authors.lastname: Kamura
authors.forename: K
authors.initials: K
authors.lastname: Unno
mesh_terms: D002462:Cell Membrane / Q000648:ultrastructure*; D006801:Humans; D008870:Microtubules / Q000648:ultrastructure*; D018234:Sarcoma, Alveolar Soft Part / Q000473:pathology / Q000648:ultrastructure*