title: Search for optimal age for weaning. Ten-year prospective study.
abstract: The effect of infant nutrition on some clinical and biochemical parameters was studied from birth in a longitudinal prospective study. The data covering the period up to 7 years were reported previously. At the age 10 years 80 children were examined. Two children have been regularly followed up because of high blood pressure. Both had been breast-fed for less than one week and are obese at present. Surprisingly serum total cholesterol was the highest in the group breast-fed for more than 6 months. There were no pronounced differences in the levels of lipoprotein cholesterol carriers. The incidence of a high (over 6.0) atherogenic index (total chol - HDL chol) x APOB/APOA1 x HDL chol) and cholesterolemia over 4.8 mmol/l was significantly (chi 2 test) higher in the group breast-fed for over 6 months. Thyroid function parameters were not affected by the duration of breast-feeding. We conclude that besides undoubtedly favorable effects of breast-feeding, some functions might be also adversely affected if it lasts for more than 6 months. For justified recommendation of optimal duration of breast-feeding all aspects should be considered and more data collected.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.
authors.forename: V
authors.initials: V
authors.lastname: Strbák
authors.forename: M
authors.initials: M
authors.lastname: Hromadová
authors.forename: L
authors.initials: L
authors.lastname: Kostálová
authors.forename: A
authors.initials: A
authors.lastname: Kapellerová
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology*; D002648:Child; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D014886:Weaning
chemical_list: D002784:Cholesterol