[Regional perfusion and oxygenation in the early resuscitation period following prolonged clinical death].
Cardiac output distribution and oxygen supply in the period starting from 15 min after resuscitation to 7 h were studied in 23 dogs exposed to 10 min clinical death caused by blood loss. The ratio of supra- to subdiaphragmatic bloodstream was virtually unchanged. Redistribution of the flow in favor of hind limb muscles was observed in the subdiaphragmatic region only between the 15th and 30th minutes. Reduction of oxygen transport during prolonged hypoperfusion (2-6 h) was associated with increased oxygen utilization in all areas which was expressed most of all in the supra-diaphragmatic region and in limb tissues and the least so in the splanchnic area, with oxygen consumption remaining at the initial level or surpassing it. A close relationship was revealed between oxygen transport and consumption in the supradiaphragmatic sector and posterior limb tissues combined with critical levels of pO2 and HbO2 in outflowing blood. Stably surviving animals differed from those dead in 1 sec by a lesser depression of the bloodstream and oxygen transport in the body on the whole and in the supradiaphragmatic region, a lesser oxygen consumption by the supradiaphragmatic region at the 15th-30th minutes, and a higher O2 consumption in 3-6 h under conditions of more marked spontaneous hypothermia.
Trubina
I E
IE
Volkov
A V
AV
Zarzhetskiĭ
Iu V
IuV
Molchanova
L V
LV
Il'icheva
R F
RF
D000818:Animals; D003643:Death; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D006470:Hemorrhage / Q000503:physiopathology; D006614:Hindlimb / Q000098:blood supply*; D008297:Male; D010101:Oxygen Consumption; D010388:Pelvis / Q000098:blood supply*; D012039:Regional Blood Flow; D012151:Resuscitation; D013997:Time Factors
Regionarnaia perfuziia i oksigenatsiia v rannem postreanimatsionnom periode posle dlitel'noĭ klinicheskoĭ smerti.