title: Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate.
abstract: The in vitro activity against herpes simplex virus type 1 of 3-methyl-but-2-enyl caffeate isolated from poplar buds or prepared by synthesis was investigated. Under conditions of one or multiple multiplication cycles, this compound, which is a minor constituent of propolis, was found to reduce the viral titer by 3 log10, and viral DNA synthesis by 32-fold.
authors.affiliation: Laboratoire de Pharmacognosie et Mycologie.
authors.forename: M
authors.initials: M
authors.lastname: Amoros
authors.forename: E
authors.initials: E
authors.lastname: Lurton
authors.forename: J
authors.initials: J
authors.lastname: Boustie
authors.forename: L
authors.initials: L
authors.lastname: Girre
authors.forename: F
authors.initials: F
authors.lastname: Sauvager
authors.forename: M
authors.initials: M
authors.lastname: Cormier
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002109:Caffeic Acids / Q000302:isolation & purification* / Q000494:pharmacology; D015342:DNA Probes; D004279:DNA, Viral / Q000096:biosynthesis; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009693:Nucleic Acid Hybridization; D010946:Plants, Medicinal / Q000737:chemistry*; D011429:Propolis / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D002109:Caffeic Acids; D015342:DNA Probes; D004279:DNA, Viral; C054126:1,1-dimethylallyl caffeic acid ester; D011429:Propolis