Stimulation of parabrachial nuclei dilates airways in cats.
Stimulation of the parabrachial nuclei has been shown to increase mean arterial pressure as well as to terminate inspiration. Nevertheless, the effect on airway caliber evoked by stimulation of the parabrachial nuclei is not known. Therefore, in chloralose-anesthetized cats, we microinjected DL-homocysteic acid (25 nl; 100 mM) into 44 sites in or near the lateral and medial parabrachial nuclei while calculating breath-by-breath total lung resistance and dynamic compliance. We found that, in 43 of these sites, microinjection of this excitatory amino acid consistently decreased total lung resistance but had no effect on dynamic compliance. The decrease in lung resistance was caused by a withdrawal of cholinergic tone to the airways. We could find no evidence that the decrease in total lung resistance evoked by stimulation of the parabrachial nuclei was caused by activation of either beta-adrenergic or nonadrenergic noncholinergic pathways. The decrease in total lung resistance evoked by stimulation of the parabrachial nuclei was not secondary to the baroreceptor reflex even though microinjection frequently increased mean arterial pressure. In addition, microinjection did not have consistent effects on phrenic nerve activity, although in individual circumstances the effect on this activity was quite large. We conclude that stimulation of cell bodies and dendrites in the parabrachial nuclei dilates the airways of anesthetized cats and that the effect is not secondary to the baroreceptor reflex.
Motekaitis
A M
AM
Department of Internal Medicine, University of California, Davis 95616.
Solomon
I C
IC
Kaufman
M P
MP
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D002415:Cats; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D004558:Electric Stimulation; D006439:Hemodynamics / Q000502:physiology; D006710:Homocysteine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D008170:Lung Compliance / Q000187:drug effects; D008845:Microinjections; D010791:Phrenic Nerve / Q000502:physiology; D011149:Pons / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000033:anatomy & histology; D013238:Stereotaxic Techniques
D006710:Homocysteine; C007956:homocysteic acid