[Cholestatic jaundice caused by amoxicillin-clavulanic acid in 4 patients].
In four patients, two men and two women aged 73, 68, 84 and 72 years respectively, reversible cholestatic liver injury was seen 28-35 days after the start of treatment with amoxycillin-clavulanic acid (Augmentin). This rare complication of amoxycillin-clavulanic acid treatment is characterized by a relatively long latent period before the onset of symptoms or biochemical abnormalities, which makes early recognition difficult. The mechanism responsible for this idiosyncratic cholestasis is unknown.
Hanssens
M
M
Algemeen Ziekenhuis H. Familie, afd. Gastro-enterologie, Gent, België.
Mast
A
A
Van Maele
V
V
Pauwels
W
W
D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000009:adverse effects; D019980:Amoxicillin-Potassium Clavulanate Combination; D002779:Cholestasis / Q000139:chemically induced*; D002969:Clavulanic Acids / Q000009:adverse effects; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Cholestatische icterus door amoxicilline-clavulaanzuur bij 4 patiënten.