title: The activity of catechol-O-methyltransferase and monoamine oxidase in the uterine artery of pigs during the oestrous cycle.
abstract: Activities of catechol-O-methyltransferase (COMT), total monoamine oxidase (MAO) and both types of MAO-A and MAO-B activities were examined in uterine artery on the 0-2nd, 13-14th and 16-18th days of the oestrous cycle in pigs. It was shown that activity of COMT was the lowest on the 0-2nd day, while on the 16-18th day of the oestrous cycle it increased by 52.4% (p < 0.05). Total activity of MAO was the highest at periovulatory phase, whereas on days 13-14 and 16-18 of oestrous cycle is was lower by 83.5% (p < 0.01) and 58.1% (p < 0.01) compared with its activity at periovulatory phase, and was higher on day 16-18 by 153.3% (p < 0.01) in relation to the luteal phase (13-14th day). MAO-A activity was 31.3% (p < 0.01) and MAO-B 62.5% (p < 0.05) of the total activity of MAO. Their activities were also highest at periovulatory phase, then decreased by 86.8-87.4% (p < 0.01) on 13-14th day and by 54.8-57.5% (p < 0.01) or 16-18th day of oestrous cycle. Activities of MAO-A and MAO-B were higher by 223.0-258.2% (p < 0.01) on 16-18th day in relation to the luteal phase (13-14th day). On that base we suppose that variations of COMT and MAO activities can significantly change the catecholamines content in the blood vessels of reproductive organs of pigs.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Agriculture and Technology, Olsztyn, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Dynarowicz
authors.forename: M
authors.initials: M
authors.lastname: Paprocki
mesh_terms: D000818:Animals; D001158:Arteries / Q000201:enzymology; D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D004971:Estrus / Q000502:physiology*; D005260:Female; D008995:Monoamine Oxidase / Q000378:metabolism*; D010060:Ovulation / Q000502:physiology; D013552:Swine / Q000502:physiology*; D014599:Uterus / Q000098:blood supply* / Q000201:enzymology
chemical_list: D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase