title: 2-deoxy-D-glucose suppresses food intake through activation of hypothalamic histamine in rats.
abstract: The aim of this experiment was to demonstrate whether brain histamine contributes to delayed suppression of food intake after administration of 2-deoxy-D-glucose (2-DG). Food intake decreased significantly for 48 h after infusion of 2-DG into the rat third cerebroventricle. This delayed decrease in food intake was abolished by depletion of neuronal histamine by intraperitoneal pretreatment with alpha-fluoromethylhistidine (160 mumol/rat), a suicide inhibitor of a histamine-synthesizing enzyme. Intracerebroventricular infusion of 24 mumol 2-DG accelerated turnover rate of hypothalamic histamine. These results indicate that the delayed feeding suppression by 2-DG is modulated through histaminergic neurons in the hypothalamus. This histaminergic response may be related, at least in part, to homeostatic control of energy metabolism in the brain.
authors.affiliation: Department of Internal Medicine I, School of Medicine, Oita Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakata
authors.forename: Y
authors.initials: Y
authors.lastname: Tamari
authors.forename: M
authors.initials: M
authors.lastname: Kang
authors.forename: H
authors.initials: H
authors.lastname: Yoshimatsu
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006633:Histamine Antagonists; D008762:Methylhistidines; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D003847:Deoxyglucose