[Effect of a sublethal dose of sodium nitrite on respiration and oxidative phosphorylation in the rat liver mitochondria].
A sublethal dose of sodium nitrates (60 mg/kg) 30 min after intraperitoneal administration to rats increases ADP-stimulated respiration, when succinate is used as the substrate. Its stimulating action is associated with an increase of efficiency of oxygen utilization. Intraperitoneal administration of succinic acid in a dose of 25 mg/kg normalizes changes induced by nitrites. Stress and hypoxic factors in the action of nitrites on aerobic processes in mitochondria are discussed.
Babs'kyĭ
A M
AM
Stefankiv
Iu S
IuS
Korobov
V M
VM
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000860:Hypoxia / Q000503:physiopathology*; D007928:Lethal Dose 50; D008930:Mitochondria, Liver / Q000187:drug effects*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012977:Sodium Nitrite / Q000494:pharmacology*; D013312:Stress, Physiological / Q000503:physiopathology*; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid
D013386:Succinates; D000244:Adenosine Diphosphate; D019802:Succinic Acid; D012977:Sodium Nitrite
Vplyv subletal'noï dozy nitrytu natriiu na dykhannia ta okysniuval'ne fosforyliuvannia u mitokhondriiakh pechinky shchura.