[D-lactate, D-lactic acidosis. Biochemical review of D-lactic acid metabolism and its clinical implications].
D-lactate is an intermediate of methylglyoxal metabolism and the article gives an overview of D-lactatate metabolism as well as discusses the possible pathological role of this lactate stereoisomer. The increase of D-lactate concentration in a given body fluid can be used as a diagnostic sign, especially in patients who underwent small bowel resection or bypass operation or who have infections or suffer from certain metabolic disorders. Determination of D-lactate concentration should be considered as a useful tool both in the diagnosis and in controlling of the management of infectious diseases, particularly in those when the smear was negative or when the patient has already received antibiotics. Spite of these, the clinical value of the measurement of D-lactate concentration cannot, however, be evaluated yet.
Kalapos
M P
MP
Department of Metabolic Regulation, Boston Biomedical Research Institute.
D000140:Acidosis, Lactic / Q000097:blood / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000097:blood / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000097:blood / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000097:blood*
D007773:Lactates
D-laktát, D-laktacidózis. A D-tejsav anyagcsere biokémiai áttekintése és klinikai vonatkozásai.