Confluentic acid and 2'-O-methylperlatolic acid, monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba.
Monoamine oxidase B (MAO-B) inhibitors were isolated from the bark of a Brazilian plant, Himatanthus sucuuba (SPR.). Assignments of the 1H- and 13C-NMR data using two dimensional (2D)-NMR techniques showed the active components to be known lichen depsides, confluentic acid (1) and 2'-O-methylperlatolic acid (2). The depside (1) showed selective inhibition of MAO-B with IC50 value of 0.22 microM.
Endo
Y
Y
Tsumura Central Research Laboratories, Ibaraki, Japan.
Hayashi
H
H
Sato
T
T
Maruno
M
M
Ohta
T
T
Nozoe
S
S
D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D001921:Brain / Q000201:enzymology; D001938:Brazil; D053630:Depsides; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology
D001565:Benzoates; D053630:Depsides; D008996:Monoamine Oxidase Inhibitors; D012459:Salicylates; C089055:2'-O-methylperlatolic acid; C089056:confluentic acid; D008995:Monoamine Oxidase