Ubiquitins revisited: further examples of within- and between-locus concerted evolution.
Ubiquitin genes provide a model for studying the effects of concerted evolution on the evolution of a family of short repeated sequences. Previous work has demonstrated the occurrence of within-locus concerted evolution and raised the question of the effectiveness of between-locus concerted evolution for ubiquitin repeats. In this study comparative analysis of additional nucleotide sequences of ubiquitin tandem repeats provides further details of within-locus concerted evolution. Moreover, the availability of multiple polyubiquitin loci and ubiquitin fusion loci within a species makes possible the detection of between-locus concerted evolution. These data indicate that concerted evolution is an effective force for homogenizing repeats between, as well as within, loci.
Tan
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Y
Department of Biology, Yale University, New Haven, Connecticut 06511.
Bishoff
S T
ST
Riley
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MA
D000818:Animals; D005075:Biological Evolution; D003001:Cloning, Molecular; D005785:Gene Conversion; D006801:Humans; D005810:Multigene Family; D011072:Poly U / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D014452:Ubiquitins / Q000235:genetics*
D014452:Ubiquitins; D011072:Poly U