title: [Modifications to a method of controlling the immunogenic activity of rabies vaccines].
abstract: To determine the immunogenic potency of different rabies vaccines, they were tested in the modified test, originally developed by the National Institutes of Health (USA). In this modification the mice used in the test were challenged with strains Vnukovo-32 and Moskva instead of strain CVS, and the vaccine was introduced not in two injections, but in a single injection. The study revealed that the use of test strain Vnukovo-32, homologous to the production vaccine strain, enhanced the absolute potency of vaccines but produced no effect on the relative potency when used with the similarly prepared reference agents. A single injection of the vaccine in the test for immunogenic potency was found to produce no changes in the results of tests for relative immunogenic potency. However, this modification needs further more extensive trials and discussion.
authors.forename: E M
authors.initials: EM
authors.lastname: Tsetlin
authors.forename: L N
authors.initials: LN
authors.lastname: Romanova
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D051379:Mice; D009316:National Institutes of Health (U.S.); D011786:Quality Control; D011818:Rabies / Q000276:immunology / Q000517:prevention & control; D011819:Rabies Vaccines / Q000276:immunology* / Q000592:standards; D013997:Time Factors; D014481:United States
chemical_list: D011819:Rabies Vaccines
vernacular_title: Modifikatsii metoda kontrolia immunogennoĭ aktivnosti antirabicheskikh vaktsin.