[An experimental validation of immunotherapy with purified staphylococcal anatoxin].
Inbred mice have proved to be a promising model for the evaluation of antigen-specific and antigen-nonspecific immunomodulating activity of purified staphylococcal toxoid in humans. This toxoid induces the formation of pronounced humoral response to homologous and heterologous infections in humans and mice. In animal experiments purified staphylococcal toxoid has shown its capacity for the correction of secondary immune deficiency of different origin; when introduced into humans having secondary immunodeficiency associated with bacterial infections of different etiology, the preparation reproduces this effect.
Semenova
I B
IB
Prozorovskaia
K N
KN
Vargin
V V
VV
Antonova
L V
LV
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation; D004195:Disease Models, Animal; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D000292:Pelvic Inflammatory Disease / Q000628:therapy; D013203:Staphylococcal Infections / Q000276:immunology / Q000628:therapy; D013208:Staphylococcal Toxoid / Q000302:isolation & purification / Q000627:therapeutic use*
D013208:Staphylococcal Toxoid
Eksperimental'noe obosnovanie immunoterapii anatoksinom stafilokokkovym ochishchennym.