[Effects of cadmium on vitamin D function involved in the regulation of phosphorus-calcium metabolism].
The role of vitamin D in regulation of phosphoric-calcium metabolism was evaluated in conditions of experimental cadmium intoxication induced by daily dietetic intake (100 micrograms/kg for 8 months) of cadmium in parallel with intake of calcium in diverse amounts. Daily requirements in vitamin D were provided in different groups of animals either with ergocalciferol (D2) or 24,25-dihydroxycholecalciferol (0.25 microgram per animal). The results of the trial suggested that despite regular supply of ergocalciferol, renal damage induced by cadmium intoxication was associated with phosphoric-calcium metabolic derangement which is likely to result from defects in renal synthesis of active vitamin D form. This was confirmed by the fact that the change of ergocalciferol for 24,25-dihydroxycholecalciferol did not produce any noticeable shifts in the phosphoric-calcium metabolism.
Volkova
N A
NA
Karpliuk
I A
IA
D015650:24,25-Dihydroxyvitamin D 3 / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002105:Cadmium Poisoning / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004872:Ergocalciferols / Q000008:administration & dosage / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014807:Vitamin D / Q000502:physiology*
D004872:Ergocalciferols; D002104:Cadmium; D014807:Vitamin D; D010758:Phosphorus; D015650:24,25-Dihydroxyvitamin D 3; D002118:Calcium
Vliianie kadmiia na funktsiiu vitamina D po regulirovaniiu fosforno-kal'tsievogo obmena v éksperimente.