title: Interleukin-1 receptor deficiency in brains from NZB and (NZB/NZW)F1 autoimmune mice.
abstract: Interleukin-1 receptors (IL-1R) are expressed in the brain and the anterior pituitary of normal mice (C3H/He, Swiss), and appear to be involved in the neuroendocrine control of the immune response. Here we have studied the IL-1R density in the brain and the pituitary from several strains of autoimmune mice (NZB, (NZB/NZW)F1, MRL/MP-lpr), using quantitative autoradiography with recombinant human [125I]IL-1 alpha as a ligand. IL-1R was similar in the brain of C3H/He, Swiss and NZW (controls) and MRL/MP-lpr mice. In NZB mice a profound deficit (10% of control mice) in IL-1R was observed exclusively in the dentate gyrus. In (NZB/NZW)F1 the deficit was about 50%. These observations were independent of sex and age. Pituitary receptors were not affected in all the strains except NZW (30% increase). Competition experiments demonstrated that the affinity of IL-1R was not modified in dentate gyrus of (NZB/NZW)F1 and NZW mice. Thus, the number of IL-1R was the only parameter affected. This deficit was not reversed by corticosterone treatment (0.2 mg/20 g body weight, i.p.) and was poorly modified by lipopolysaccharide treatment (0.1 mg/20 g body weight, i.p.) compared to C3H/He mice. In conclusion, this central IL-1R deficit is unlikely to be the consequence of occupancy by abnormal synthesis of brain IL-1. This abnormality is tissue-specific with hereditary autosomal transmission. The role of central IL-1R in neuroimmunoendocrine interactions and in autoimmunity remains to be clarified.
authors.affiliation: Institut Pasteur, Paris, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Tehrani
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
authors.forename: C
authors.initials: C
authors.lastname: Marquette
authors.forename: H
authors.initials: H
authors.lastname: Dietrich
authors.forename: F
authors.initials: F
authors.lastname: Haour
authors.forename: G
authors.initials: G
authors.lastname: Wick
mesh_terms: D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism*; D001923:Brain Chemistry; D003345:Corticosterone / Q000494:pharmacology; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008814:Mice, Inbred NZB; D010902:Pituitary Gland / Q000737:chemistry; D017472:Receptors, Interleukin-1 / Q000032:analysis* / Q000502:physiology; D012737:Sex Factors
chemical_list: D008070:Lipopolysaccharides; D017472:Receptors, Interleukin-1; D003345:Corticosterone