[Changes of neutrophil functions resulting from intact and injured liver cells in mice].
Separately cultured parenchymatous and nonparenchymatous liver cells of mice produce factors to influence migration properties and oxygen-dependent metabolism of neutrophils. Cell-free supernatant of intact parenchymatous cells activates neutrophil chemotaxis only, while supernatant of intact nonparenchymatous cells stimulates oxygen-dependent reactions as well. Injure of the liver cells with 5 mM tetrachlormethane significantly increases neutrophil functional activation. Treatment of the liver cells with anti-liver antibodies (0.5 mg/ml) results in suppression of neutrophil activation. At the same time, supernatant of the liver cells treated with normal rabbit antibodies (0.5 mg/ml) possessed neutrophil stimulating properties, nonparenchymatous cell factors stimulating mainly the neutrophil oxygen-dependent metabolism.
Portnychenko
A G
AG
Makohon
N V
NV
Aleksieieva
I M
IM
D000818:Animals; D000906:Antibodies / Q000276:immunology; D002251:Carbon Tetrachloride / Q000008:administration & dosage; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte; D007108:Immune Tolerance; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000166:cytology* / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010101:Oxygen Consumption
D000906:Antibodies; D002251:Carbon Tetrachloride
Zminy funktsionalńoĭ aktyvnosti neĭtrofiliv pid vplyvom faktoriv, shcho vydiliaiutśia intaktnymy ta urazhenymy klitynamy pechinky mysheĭ.