Thermal behavior and elastic properties of dimyristoyl phosphatidylcholine bilayers under the effect of pentoxifylline.
We have investigated the effect on dimyristoyl phosphatidylcholine bilayers of pentoxifylline, a derivative of xanthine by using two optical techniques, quasi-elastic light scattering (QLS) and Fourier transform infrared spectroscopy (FT-IR). The results show that in the presence of pentoxifylline, the bilayer phase transition point is lowered and that the elastic modulus is decreased. The FT-IR results indicate strong interactions in the aqueous interface regions of the bilayers. We discussed these results comparatively with those obtained from flavonoid derivatives whose effect was analogous and previously studied.
Azize
B
B
Laboratoiere de Spectroscopie Biomoléculaire, CNRS URA no. 1430, UFR de Médecine et Biologie Humaine, Université Paris XIII, Bobigny, France.
Cao
A
A
Perret
G
G
Taillandier
E
E
D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D004548:Elasticity; D008027:Light; D008051:Lipid Bilayers; D008433:Mathematics; D010431:Pentoxifylline; D012542:Scattering, Radiation; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics
D008051:Lipid Bilayers; D010431:Pentoxifylline; D004134:Dimyristoylphosphatidylcholine