[The effect of pentoxifylline and nicergoline on the systemic and cerebral hemodynamics and on the blood rheological properties in patients with an ischemic stroke and atherosclerotic lesions of the major cerebral arteries].
Pentoxifylline versus nicergoline therapy has been studied in 56 patients with atherosclerosis of major cerebral arteries who had ischemic apoplexy. Pentoxifylline enhances circulation primarily in the stenotic vessels, while nicergoline in the intact cerebral arteries. The former is more potent in inducing antiaggregation inhibiting spontaneous platelet and red cell aggregation and reducing blood viscosity. The results of the study suggest better response in case of pentoxifylline treatment of patients with hypo- and eukinetic circulation, while in nicergoline treatment hyperkinetic hemodynamics patients benefit more in view of the drug cardiodepressive activity.
Gara
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D000208:Acute Disease; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009530:Nicergoline / Q000494:pharmacology / Q000627:therapeutic use*; D010431:Pentoxifylline / Q000494:pharmacology / Q000627:therapeutic use*
D009530:Nicergoline; D010431:Pentoxifylline
Vliianie pentoksifillina i nitsergolina na sistemno-tserebral'nuiu gemodinamiku u reologicheskie svoĭstva krovi u bol'nykh ishemicheskim insul'tom na fone ateroskleroticheskogo porazheniia magistral'nykh arteriĭ golovy.