Sufentanil pharmacokinetics in young adult and elderly surgical patients.
Sufentanil 3 microgram kg-1 was administered as an intravenous (i.v.) bolus to 12 elderly patients, aged 65-87 years and 12 young adults, 17-43 years of age, all ASA class I-II, scheduled for orthopaedic surgery. Plasma sufentanil concentrations were measured by a specific radioimmunoassay. Plasma concentration time-curves for the young adult and the elderly groups were superimposible. Pharmacokinetic parameters were calculated from the derived compartmental models. Elimination half-lives, clearance and total volumes of distribution were calculated with non-compartment methods. The major pharmacokinetic parameters, elimination half-life, clearance and volume of distribution did not differ between both groups. The age-related differences in the action of sufentanil cannot be explained by its pharmacokinetic properties.
Helmers
J H
JH
Hospital Eemland-Locatie De Lichtenberg, Amersfoort, The Netherlands.
van Leeuwen
L
L
Zuurmond
W W
WW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000771:Anesthesia, Intravenous; D001842:Bone and Bones / Q000601:surgery; D005260:Female; D006207:Half-Life; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D017409:Sufentanil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D017409:Sufentanil