Larger neuronal size overwhelms maintenance capacity with aging.
Neuritic plaque-affected neurons may transform into neurofibrillary tangle-bearing neurons in the aging human brain, at varying speeds depending on cell size. Smaller neurons have a greater chance to overcome the plaque stage and survive, without tangles.
Dani
S U
SU
Institut für Neuropathologie, Medizinische Hochschule Hannover, Germany.
D000375:Aging / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000473:pathology; D006801:Humans; D008959:Models, Neurological; D009410:Nerve Degeneration; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*
D009419:Nerve Tissue Proteins