The up-regulation of trkA and trkB in dorsal column astrocytes following dorsal rhizotomy.
One week after rat dorsal root fibers were severed, immunoreactivity for the high affinity neurotrophin receptors, trkA and trkB, was up-regulated on glial cells in the spinal cord dorsal column. Immunoreactivity for glial fibrillary acidic protein (GFAP) also increased. In contrast, no changes in immunoreactivity for trkA or trkB, or for GFAP were observed in the brainstem cuneate nucleus, a principal termination site for many of the severed dorsal root fibers.
Foschini
D R
DR
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5635.
Kestler
A M
AM
Egger
M D
MD
Crockett
D P
DP
D000818:Animals; D001253:Astrocytes / Q000201:enzymology / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000166:cytology / Q000201:enzymology; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D009412:Nerve Fibers / Q000201:enzymology / Q000378:metabolism; D009475:Neurons, Afferent / Q000201:enzymology / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology*
D005904:Glial Fibrillary Acidic Protein; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases