Intermediates in the oxidation of a dihydropyridine derivative of AZT related to AIDS dementia, studied by nanosecond laser photolysis.
Radicals of the AZT derivative 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-2',3'-dideo xythymidine) were obtained on exposure of this compound in alkaline aqueous solution to pulsed laser emission of lambda = 355 nm and pulsewidth 2 ns FWHM. The radical formation was shown to be due to photoelectron ejection from the pyridine group following two-step excitation of the compound. The radicals were found to deprotonate rapidly. Electrochemical analysis showed that the photoionization does not affect the azido group.
Lindqvist
L
L
Laboratoire de Photophysique Moléculaire, Université de Paris-Sud, Orsay, France.
Czochralska
B
B
Kawczynski
W
W
D015526:AIDS Dementia Complex / Q000188:drug therapy*; D004095:Dihydropyridines / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007834:Lasers; D010782:Photolysis; D013997:Time Factors; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use
D004095:Dihydropyridines; C056534:5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine; D015215:Zidovudine