[The evaluation of the efficacy and safety of using nalbuphine hydrochloride (Nubain) in patients in the early postoperative period].
Nubaine (N) was used in 92 patients operated on the lungs, heart and major vessels, abdominal organs. N at a dose of 0.3 mg/kg caused adequate analgesia in 62-85% of cases on days 1-3 after surgery; it is an effective analgesic among those used in patients with acute postoperative pain. The effect of N on circulation, respiration, gas exchange, metabolism, and hormonal status was studied. It has been shown that N is a safe agent which has no considerable effect on respiration, hemodynamics, blood gas composition, and metabolism. In patients at high risk analgesia with N caused no serious side effects.
Nikoda
V V
VV
Sandrikov
V A
VA
Lebedeva
R N
RN
Vinnitskiĭ
L I
LI
Egorova
I A
IA
Petrov
R O
RO
Chizhov
A I
AI
Poroĭkova
M V
MV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009266:Nalbuphine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D011182:Postoperative Care; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013514:Surgical Procedures, Operative; D013997:Time Factors
D009266:Nalbuphine
Otsenka éffektivnosti i bezopasnosti primeneniia nalbufina gidrokhlorida (nubaina) u bol'nykh v rannem posleoperatsionnom periode.