[Stress-modulating action of medium molecular weight peptides, isolated from blood of intact and burned animals].
Medium-weight molecular peptide (MMP) fractions isolated from blood of intact dogs and dogs with burns changed the response of rat thymus and bone-marrow neutrophilic granulocytes to 9-hour immobilization. Various MMP fractions were capable both of intensifying and decreasing the consequences of immobilization stress. Intravenous infusion of MMP isolated from blood of dogs with burns reproduced the effects of immobilization stress in relation to bone-marrow granulocytes. The limiting effect of MMP on stress-induced injury to the stomach was demonstrated. The MMP fractions also modified stress resistance of mice in the induced swimming test. The interrelation of the MMP stress-modulating activity and their property of aggravating the sequelae of thermal burn was demonstrated.
Volchegorskiĭ
I A
IA
Tseĭlikman
V E
VE
Skobeleva
N A
NA
Lifshits
R I
RI
D000818:Animals; D002056:Burns / Q000097:blood* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D008297:Male; D008970:Molecular Weight; D010455:Peptides / Q000097:blood / Q000502:physiology*; D012016:Reference Values; D013312:Stress, Physiological / Q000097:blood* / Q000503:physiopathology
D010455:Peptides
Stressmoduliruiushchee deĭstvie srednemolekuliarnykh peptidov, vydelennykh iz krovi intaktnykh i obozhzhennykh zhivotnykh.