title: [The protective properties of the lysosomal form of Pseudomonas aeruginosa anatoxin in a test of its active protection of experimental animals].
abstract: The protective activity of the liposomal form of P. aeruginosa toxoid and intact phosphatidylethanolamine liposomes has been evaluated in mice with experimental P. aeruginosa infection. It has been revealed that the liposomal form of P. aeruginosa toxoid, introduced in a single injection, ensures the formation of more intense and prolonged immunity in comparison with that induced by the toxoid adsorbed on aluminum hydroxide. This investigation has revealed that intact phosphatidylethanolamine liposomes also possess protective properties, protecting 10-36.7% of the animals from infection with P. aeruginosa toxigenic strain.
authors.forename: V V
authors.initials: VV
authors.lastname: Minukhin
authors.forename: N S
authors.initials: NS
authors.lastname: Brodinova
authors.forename: N A
authors.initials: NA
authors.lastname: Mikhaĭlova
authors.forename: N N
authors.initials: NN
authors.lastname: Ivanova
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Tsyganenko
authors.forename: V N
authors.initials: VN
authors.lastname: Vasil'chenko
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D008081:Liposomes; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000401:mortality / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013997:Time Factors; D014121:Toxoids / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D014121:Toxoids
vernacular_title: Izuchenie protektivnykh svoĭstv liposomal'noĭ formy anatoksina Pseudomonas aeruginosa v teste aktivnoĭ zashchity éksperimental'nykh zhivotnykh.