[The determination of the optimal inoculation dose of an oral cholera bivalent chemical vaccine in a controlled trial of the vaccination of children and adolescents].
The reactogenicity and immunological effectiveness of different doses of cholera vaccine for oral administration (in tablets), containing choleragen toxoid, Ogawa and Inaba O-antigens and some of Vibrio cholerae exoenzymes, have been tested on 143 children aged 2-17 years. In this investigation the optimum immunization doses of the preparation have been established: two tablets containing 100,000 binding units (BU) of the toxoid and 2,500 units of O-antigen for children 11-14 years; four tablets containing 200,000 BU of the toxoid and 5,000 units of O-antigen for adolescents aged 15-17 years. An essential advantage of the oral vaccine over vaccines intended for parenteral administration lies in its capacity for inducing the accumulation of secretory antibodies (coproantibodies) in practically all vaccinees.
Sumarokov
A A
AA
Dzhaparidze
M N
MN
Eliseev
Iu Iu
IuIu
Nikitina
G P
GP
Poliakov
K A
KA
Kazakova
E S
ES
Meleshchenko
M V
MV
Tsareva
N M
NM
Reznikov
Iu B
IuB
Adamova
G V
GV
D000284:Administration, Oral; D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D022121:Cholera Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005243:Feces / Q000737:chemistry; D006801:Humans; D012449:Safety; D013607:Tablets; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014734:Vibrio cholerae / Q000276:immunology
D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D013607:Tablets; D014614:Vaccines, Synthetic
Opredelenie otpimal'noĭ privivochnoĭ dozy oral'noĭ kholernoĭ bivalentnoĭ khimicheskoĭ vaktsiny v kontroliruemom opyte vaktsinatsii deteĭ i podrostkov.