title: Nonoperative management of non-small cell lung cancer: the current cancer and leukemia group B experience.
abstract: The Cancer and Leukemia Group B (CALGB) is studying nonoperative management in two subgroups of patients with advanced non-small cell lung cancer. In patients with regional disease, primarily those with bulky N2 or T4 disease or those with contralateral mediastinal involvement (N3), a phase III trial is under way to explore concurrent carboplatin as intensification of local therapy and additional systemic treatment. This builds on prior CALGB work demonstrating the benefits of induction chemotherapy prior to radiation for selected patients with stage III disease. For patients with still more advanced disease, a trial evaluating efficacy and cost of two supportive care modalities during intensive chemotherapy is about to begin accrual. Following its completion, the CALGB plans to evaluate new chemotherapy combinations based on one or more of the exciting new agents now being tested for the nonoperative management of non-small cell lung cancer.
authors.affiliation: Division of Hematology/Oncology, University of California, San Diego, School of Medicine 92130.
authors.forename: M R
authors.initials: MR
authors.lastname: Green
authors.forename: M P
authors.initials: MP
authors.lastname: Kosty
authors.forename: J J
authors.initials: JJ
authors.lastname: Muscato
authors.forename: S
authors.initials: S
authors.lastname: Graziano
authors.forename: R O
authors.initials: RO
authors.lastname: Dillman
authors.forename: G H
authors.initials: GH
authors.lastname: Clamon
authors.forename: J
authors.initials: J
authors.lastname: Herndon
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000532:radiotherapy; D017024:Chemotherapy, Adjuvant; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy