title: Cytotoxic activity of some gold(III) complexes.
abstract: The [Au(N-MeIm)Cl3], [Au(2-MeBO)Cl3] and [Au(2,5-diMeBO)Cl3] complexes (where N-MeIm = N-methylimidazole, 2-MeBO = 2-methylbenzoxazole and 2,5-diMeBO = 2,5-dimethylbenzoxazole), had been previously prepared and characterized by the Author. These compounds, when tested in vitro against murine leukemia cell lines L1210, human ovarian carcinoma A2780 and their sublines L1210/CDDP and A2780/CDDP resistant to cisplatin, in comparison with cisplatin and carboplatin, showed an interesting cytotoxicity, extended to resistant sublines.
authors.affiliation: Istituto di Radiologia, Università di Cagliari, Ospedale Civile, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cossu
authors.forename: Z
authors.initials: Z
authors.lastname: Matovic
authors.forename: D
authors.initials: D
authors.lastname: Radanovic
authors.forename: G
authors.initials: G
authors.lastname: Ponticelli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D006046:Gold; D002945:Cisplatin