title: Parapsoriasis in two children: a clinical, immunophenotypic, and immunogenotypic study.
abstract: Parapsoriasis has been described rarely in childhood; a few reports mention this condition as preceding early mycosis fungoides. We report a boy age 15 and a girl age 8 years with different clinical features of parapsoriasis who were followed clinically and histologically for about four years. Immunophenotyping of the skin infiltrate and a T cell receptor gene rearrangement analysis were performed on each. The infiltrate was composed mainly of CD4+ and CD45+ lymphocytes in the first patient and of CD8+ and CD45+ in the second. No T cell receptor gene rearrangements were found. The paucity of knowledge about the evolution of this entity in childhood and its relationship to mycosis fungoides makes follow-up critical. The importance of immunophenotyping and immunogenotyping is particularly stressed.
authors.affiliation: Institute of Dermatologic Clinic I and Pediatric Dermatology, University of Milan, I.R.C.C.S. Ospedale Maggiore, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Menni
authors.forename: R
authors.initials: R
authors.lastname: Piccinno
authors.forename: L
authors.initials: L
authors.lastname: Crosti
authors.forename: E
authors.initials: E
authors.lastname: Berti
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D010267:Parapsoriasis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016133:Polymerase Chain Reaction