[Effect of fish oil with a high content of polyunsaturated fatty acids (eiconole) on myogenic tone and magnitude of the constrictor and dilator responses in isolated tail artery of rats].
A long-term excess of polyunsaturated fatty acids in diet resulted in more than twofold reduced myogenic tone of isolated rat tail artery. Vasoconstrictory responses to norepinephrine and phenylephrine were reduced as well. At the same time the excess of dietary polyunsaturated fatty acids resulted in enhanced vasodilatory responses to isoproterenol and acetylcholine. This complex of universally targeted shifts may play a significant part in the antihypertensive effect of excessive polyunsaturated fatty acids in diet.
Meerson
F Z
FZ
Mashina
S Iu
SIu
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001158:Arteries; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D010656:Phenylephrine; D007545:Isoproterenol; D000109:Acetylcholine; D009638:Norepinephrine
Vliianie ryb'ego zhira s vysokim soderzhaniem polinenasyshchennykh zhirnykh kislot (éĭkonola) na miogennyĭ tonus i velichinu konstriktornykh i dilatatornykh reaktsiĭ izolirovannoĭ khvostovoĭ arterii krysy.