Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade.
Antibody-antigen complexes initiate the inflammatory response and are central to the pathogenesis of tissue injury. The classical model for this immunopathological cascade, the Arthus reaction, was reinvestigated with a murine strain deficient in Fc receptor expression. Despite normal inflammatory responses to other stimuli, the inflammatory response to immune complexes was markedly attenuated. These results suggest that immune complex-triggered inflammation is initiated by cell bound Fc receptors and is then amplified by cellular mediators and activated complement. These results redefine the inflammatory cascade and may offer other approaches for the study and treatment of immunological injury.
Sylvestre
D L
DL
DeWitt Wallace Research Laboratory, Sloan-Kettering Institute, New York, NY 10021.
Ravetch
J V
JV
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001183:Arthus Reaction / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D003165:Complement System Proteins / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000502:physiology; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology
D000936:Antigen-Antibody Complex; D011961:Receptors, Fc; D017452:Receptors, IgG; D003165:Complement System Proteins