[An evaluation of the protective activity of a multicomponent vaccine made from opportunistic microorganisms in the oral method of immunization in a model of local staphylococcal infection].
The protective activity of a multicomponent vaccine against S. aureus, prepared from Staphylococcus, Klebsiella, Proteus and Escherichia coli antigens, intended for oral administration, has been studied on the model of a local staphylococcal infection. The study has revealed that the vaccine, when administered orally to mice, prevents the development of gangrene in the paw, the death of the animals, and essentially decreases the local focus of infection. The optimum treatment schedule consists of five administrations of the preparation in doses of 2 mg.
Efremov
V N
VN
Poliachenko
V M
VM
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology*; D007114:Immunization; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D011514:Proteus vulgaris / Q000276:immunology*; D013203:Staphylococcal Infections / Q000401:mortality / Q000469:parasitology*; D013211:Staphylococcus aureus / Q000276:immunology*; D013997:Time Factors; D017778:Vaccines, Combined / Q000008:administration & dosage* / Q000276:immunology
D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined
Otsenka protektivnoĭ aktivnosti polikomponentnoĭ vaktsiny iz uslovno-patogennykh mikroorganizmov pri oral'nom metode immunizatsii na modeli lokal'noĭ stafilokokkovoĭ infektsii.