title: Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease.
abstract: Apolipoprotein E (apoE) is a protein involved in the transport of lipids and a component of Alzheimer's disease (AD) plaques. There are three common alleles of the apoE gene, designated epsilon 2, epsilon 3 and epsilon 4. An association between familial and sporadic AD and the epsilon 4 allele was recently reported. We have investigated Swedish Alzheimer patients and controls. The epsilon 4 allele frequency in familial and sporadic cases and in controls was 47, 22 and 18%, respectively. There was no significant difference between sporadic AD and controls but in familial cases the increased epsilon 4 allele frequency previously reported was confirmed.
authors.affiliation: Karolinska Institute, Department of Geriatric Medicine, Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Lannfelt
authors.forename: L
authors.initials: L
authors.lastname: Lilius
authors.forename: M
authors.initials: M
authors.lastname: Nastase
authors.forename: M
authors.initials: M
authors.lastname: Viitanen
authors.forename: L
authors.initials: L
authors.lastname: Fratiglioni
authors.forename: G
authors.initials: G
authors.lastname: Eggertsen
authors.forename: L
authors.initials: L
authors.lastname: Berglund
authors.forename: B
authors.initials: B
authors.lastname: Angelin
authors.forename: J
authors.initials: J
authors.lastname: Linder
authors.forename: B
authors.initials: B
authors.lastname: Winblad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism*; D006801:Humans; D012306:Risk
chemical_list: D001057:Apolipoproteins E