Do chemokines mediate inflammatory cell invasion of the central nervous system parenchyma?
Inflammatory cell recruitment into the central nervous system (CNS) is a critical step in the response to diverse insults, including infection, trauma and infarction, as well as immune-mediated disorders such as multiple sclerosis (MS). Despite considerable advances in understanding immune surveillance and antigen recognition in the CNS, the signals resulting in parenchymal inflammation are incompletely understood. Members of a novel family of chemo-attractant cytokines, the chemokines, are made in the CNS and are emerging as likely mediators of inflammatory cell migration into the CNS.
Tani
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Samuel Rosenthal Multiple Sclerosis Research Laboratory, Cleveland Clinic Foundation, OH 44195-5285.
Ransohoff
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RM
D000818:Animals; D002465:Cell Movement; D002490:Central Nervous System / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D002630:Chemotactic Factors / Q000494:pharmacology / Q000502:physiology*; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D007267:Injections; D007962:Leukocytes / Q000502:physiology; D018121:Receptors, Cytokine / Q000378:metabolism
D002630:Chemotactic Factors; D016207:Cytokines; D018121:Receptors, Cytokine