[Features of mast cell status and blood coagulation during long-term administration of noradrenaline in mountain dogs].
The total number of mast cells and their forms is increased, degranulation is weakly marked in dogs permanent of medium altitude (1650 m) in comparison with low altitude dogs (760 m) after the long-term NA injections addition with reaction similarities some differences were observed. The total number of mast cells is decreased less considerably, the number of average forms of maturity and to some extent the number of the third power degranulation are increased in altitude dogs. The decrease of the high altitude adaptive heparin level is observed, the activity of fibrinolytic system is marked facilitating the prevention of microcirculatory disturbances. Thus, mast cells and hemocoagulation systems of altitude are more resistant to the long-term noradrenaline loadings.
Frolenko
V I
VI
Isabaeva
V A
VA
Zakharov
G A
GA
Gorokhova
G I
GI
Novikova
N P
NP
D000531:Altitude; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D015550:Cell Degranulation; D004285:Dogs; D005342:Fibrinolysis; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*
D009638:Norepinephrine
Osobennosti sostoianiia tuchnykh kletok i gemokoaguliatsii pri dlitel'nom vvedenii noradrenalina u gornykh sobak.