title: 1,2,3-Triazole[4,5-d]pyridazines--II. New derivatives tested on adenosine receptors.
abstract: This paper reports the synthesis and biological evaluation towards A1 and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Pisa.
authors.forename: G
authors.initials: G
authors.lastname: Biagi
authors.forename: I
authors.initials: I
authors.lastname: Giorgi
authors.forename: O
authors.initials: O
authors.lastname: Livi
authors.forename: V
authors.initials: V
authors.lastname: Scartoni
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: P
authors.initials: P
authors.lastname: Tacchi
authors.forename: S
authors.initials: S
authors.lastname: Merlino
authors.forename: M
authors.initials: M
authors.lastname: Pasero
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D002849:Chromatography, Gas; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D017072:Neostriatum / Q000378:metabolism; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000187:drug effects*; D012756:Sheep
chemical_list: D011724:Pyridazines; D018047:Receptors, Purinergic P1