title: Paraneoplastic vasculitic neuropathy: immunohistochemical studies on a biopsied nerve and post-mortem examination.
abstract: We studied a patient with paraneoplastic vasculitic neuropathy (PVN) associated with a carcinoma of the common bile duct. Immunohistochemical analysis of the biopsied sural nerve showed that the cellular infiltrates in the vascular lesions were composed primarily of CD8-positive T lymphocytes and macrophages. Pathogenic significance of the T-cell-mediated immunological reaction was suggested. Post-mortem examination revealed the absence of systemic vasculitis, which may be a characteristic feature of PVN. The patient responded to immunosuppressive treatment. We discuss the efficacy and the risk of immunosuppressive therapy for PVN.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumuro
authors.forename: S
authors.initials: S
authors.lastname: Izumo
authors.forename: F
authors.initials: F
authors.lastname: Umehara
authors.forename: T
authors.initials: T
authors.lastname: Arisato
authors.forename: I
authors.initials: I
authors.lastname: Maruyama
authors.forename: S
authors.initials: S
authors.lastname: Yonezawa
authors.forename: H
authors.initials: H
authors.lastname: Shirahama
authors.forename: E
authors.initials: E
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D003138:Common Bile Duct Neoplasms / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology; D014657:Vasculitis / Q000209:etiology / Q000473:pathology*