14-epidihydrocochlioquinone B and 14-epicochlioquinone B, antibiotics from fermentations of the ascomycete Neobulgaria pura: structure elucidation and effects on platelet aggregation.
14-Epicochlioquinone B (1) and 14-epidihydrocochlioquinone B (2) were isolated from submerged cultures of Neobulgaria pura (Pers. ex Fr.) Petrak. 14-Epicochlioquinone B is a potent inhibitor of human and bovine platelet aggregation stimulated by different inducers. 14-Epidihydrocochlioquinone B does not inhibit the aggregation of platelets. In addition, both 1 and 2 exhibited cytotoxic and antimicrobial activities.
Lorenzen
K
K
LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
Anke
T
T
Anders
U
U
Hindermayr
H
H
Hansske
F
F
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001203:Ascomycota / Q000378:metabolism*; D002417:Cattle; D003094:Collagen / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014966:Xanthenes / Q000737:chemistry* / Q000494:pharmacology
C088862:14-epidihydrocochlioquinone B; D000900:Anti-Bacterial Agents; D010975:Platelet Aggregation Inhibitors; D014966:Xanthenes; C088861:14-epicochlioquinone B; D003094:Collagen