2,6-Disubstituted aryl carboxylic acids, leaving groups "par excellence" for benzisothiazolone inhibitors of human leukocyte elastase.
Subramanyam
C
C
Department of Medicinal Chemistry, Sterling Winthrop Pharmaceutical Research Division, Collegeville, Pennsylvania 19426-0900.
Bell
M R
MR
Carabateas
P
P
Court
J J
JJ
Dority
J A
JA
Ferguson
E
E
Gordon
R
R
Hlasta
D J
DJ
Kumar
V
V
Saindane
M
M
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D019272:Leukocyte Elastase; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D002264:Carboxylic Acids; D011480:Protease Inhibitors; D013844:Thiazoles; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; C015699:1,2-benzisothiazoline-3-one