In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.
The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.
Basco
L K
LK
Laboratoire de Parasitologie, Institut de Médecine et d'Epidémiologie Africaines, Hôpital Bichat-Claude Bernard, Paris, France.
Mitaku
S
S
Skaltsounis
A L
AL
Ravelomanantsoa
N
N
Tillequin
F
F
Koch
M
M
Le Bras
J
J
D000166:Acridines / Q000302:isolation & purification / Q000494:pharmacology*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D015363:Quinolones / Q000302:isolation & purification / Q000494:pharmacology*
D000166:Acridines; D000470:Alkaloids; D000962:Antimalarials; D015363:Quinolones; D002738:Chloroquine