[Role of the striatal serotoninergic apparatus in Parkinsonian syndrome].
Injected into the rat caudate nuclei (CN) serotonin promotes the generator of pathologically enhanced excitation (GPEE) in CN and parkinsonian symptoms, induced by MPP+ injection into substantia nigra. Serotonin antibody injected in CN decreases the GPEE activity and partly suppresses the parkinsonian symptoms. The role of serotoninergic system in parkinsonism is discussed.
Kryzanovskiĭ
G N
GN
Magaeva
S V
SV
Trekova
N A
NA
Vetrilé
L A
LA
Basharova
L A
LA
Atadzhanov
M A
MA
D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D000937:Antigen-Antibody Reactions; D003342:Corpus Striatum / Q000503:physiopathology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology*; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000276:immunology / Q000502:physiology*
D012701:Serotonin; D015655:1-Methyl-4-phenylpyridinium
Uchastie serotoninergicheskogo apparata striatuma v parkinsonicheskom sindrome.