title: Fyn expression during early neurogenesis in mouse embryos.
abstract: Fyn is a member of the Src family of tyrosine kinases which are thought to play important roles in cell to cell interactions during morphogenesis. The developmental profile of Fyn expression was examined using mutant mice in which lacZ gene was introduced into this locus. The expression was characteristic in the neural system. Though at low levels, it was detected in the headfold at embryonic day (E) 7.5 and in the luminal surface of neuroectoderm along the entire neural groove at E8.5. The expression appeared regional in rhombomeres at E8.5 and E9.5. Consistent expression was also found at a low level in the notochord. The expression was high in later stages of the neural tube which consists of three layers; it was in the marginal layer but not in the germinal layer. High expression was also found in developing dorsal root filaments of neural crest origin. Non-expression in dividing neuroepithelial cells and expression in developing neural fibers appeared ubiquitous features of Fyn expression throughout the entire brain.
authors.affiliation: Laboratory of Molecular Oncology, Tsukuba Life Science Center, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: Y
authors.initials: Y
authors.lastname: Shigetani
authors.forename: Y
authors.initials: Y
authors.lastname: Furuta
authors.forename: S
authors.initials: S
authors.lastname: Nada
authors.forename: N
authors.initials: N
authors.lastname: Okado
authors.forename: Y
authors.initials: Y
authors.lastname: Ikawa
authors.forename: S
authors.initials: S
authors.lastname: Aizawa
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000235:genetics; D051076:Proto-Oncogene Proteins c-fyn; D001616:beta-Galactosidase / Q000032:analysis
chemical_list: D011518:Proto-Oncogene Proteins; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn; D001616:beta-Galactosidase