Beneficial effects of myristic, stearic or oleic acid as part of liposomes on experimental infection and antitumor effect in a murine model.
Liposomes consisting of dicetyl-phosphate, cholesterol, lecithin and stearic or myristic or oleic acid, exert a protective effect for mice against experimental infection by Salmonella typhimurium, and delay both the onset and mortality B16 melanoma in these animals. Liposomes labelled with 3H-myristic acid were used as probes in the spleen and liver. We found that the treatment schedule rather than route of administration of liposomes, is important. The results show that in order to induce protection, preventive treatment must start at least three days before. Longer treatments do not increase the degree of protection, and treatments started at the same time as, or following experimental infection or tumor transplantation, have no effect.
Galdiero
F
F
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, II Università degli Studi di Napoli.
Carratelli
C R
CR
Nuzzo
I
I
Bentivoglio
C
C
De Martino
L
L
Gorga
F
F
Folgore
A
A
Galdiero
M
M
D000818:Animals; D016470:Bacteremia / Q000382:microbiology / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D007239:Infections; D008081:Liposomes / Q000493:pharmacokinetics; D008099:Liver / Q000648:ultrastructure; D008546:Melanoma, Experimental / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D019814:Myristic Acid; D009227:Myristic Acids / Q000627:therapeutic use*; D019301:Oleic Acid; D009829:Oleic Acids / Q000627:therapeutic use*; D012480:Salmonella Infections / Q000382:microbiology / Q000628:therapy*; D012486:Salmonella typhimurium; D013154:Spleen / Q000648:ultrastructure; D013229:Stearic Acids / Q000627:therapeutic use*
D008081:Liposomes; D009227:Myristic Acids; D009829:Oleic Acids; D013229:Stearic Acids; D019814:Myristic Acid; D019301:Oleic Acid; C031183:stearic acid