Genomic mismatch scanning in pedigrees.
The new method of genomic mismatch scanning allows the high-resolution mapping of identity by descent on the chromosomes of two related individuals. Modelling recombinant events as a continuous Markov process, the authors design experiments and statistical tests for the use of this technique on sets of affected individuals in pedigrees in order to determine candidate regions for genes contributing to the disease.
Thomas
A
A
School of Mathematical Sciences, University of Bath, UK.
Skolnick
M H
MH
Lewis
C M
CM
D000818:Animals; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D008390:Markov Chains; D008957:Models, Genetic; D015233:Models, Statistical; D010375:Pedigree; D016012:Poisson Distribution; D011995:Recombination, Genetic