[Experimental study of radiation protective efficacy of Vinca alkaloid drugs].
In experiments with rats and dogs exposed to whole-body nonlethal and lethal gamma-radiation (2; 2,9 or 7.5 Gy) the radioprotective efficacy Vinca alkaloids drugs was investigated. It has been shown that enterally administered Vincanor (10 mg/kg over a three-day period) increased the radioresistance of animals. The prolonged radioprotective effect of Vincanor are discussed with regard to the phenomenon of sequential partial DNA synthesis inhibition in radiosensitive tissues.
Krasil'nikov
I I
II
Zhakovko
E B
EB
Chigareva
N G
NG
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis; D004285:Dogs; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D014749:Vincamine / Q000008:administration & dosage / Q000494:pharmacology; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D004247:DNA; D014749:Vincamine
Eksperimental'noe izuchenie radiozashchitnoĭ éffektivnosti lekarstvennykh preparatov na osnove alkaloidov vinkovoĭ gruppy.