Increased serum soluble interleukin-2 receptors in Caucasian and Korean schizophrenic patients.
Recent studies have identified immunologic abnormalities in some schizophrenic subjects. This experiment replicates previous findings that serum soluble interleukin-2 receptors (SIL-2Rs) are elevated in schizophrenic patients, and is the first study to describe this phenomenon in non-Caucasian patients. Despite differences between Korean and Caucasian schizophrenic patients in absolute serum SIL-2R levels, both groups were significantly elevated when compared with their respective ethnic control groups (477 +/- 171 U/ml versus 354 +/- 172 U/ml and 763 +/- 347 U/ml versus 567 +/- 231 U/ml, respectively). Neither age, gender, medication status, nor duration of illness correlated with SIL-2R levels. These findings are further evidence that immune activation is present, regardless of ethnic origin, in some schizophrenic patients.
Rapaport
M H
MH
Department of Psychiatry, University of California, San Diego.
McAllister
C G
CG
Kim
Y S
YS
Han
J H
JH
Pickar
D
D
Nelson
D L
DL
Kirch
D G
DG
Paul
S M
SM
D000328:Adult; D001213:Asian / Q000523:psychology*; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012559:Schizophrenia / Q000208:ethnology / Q000276:immunology*; D012565:Schizophrenic Psychology
D015375:Receptors, Interleukin-2