[Specificity of surface antigen and function of BAL T cells].
To elucidate the pathogenesis of sarcoidosis, we mainly investigated the surface molecules including adhesion molecules on BAL T cells and the functions of BAL T cells such cytokine production, [Ca2+] mobilization, PKC expression. Results are following. Adhesion molecules were up-regulated on BAL T cells compared with peripheral T cells, but cytokine production was decreased via TcR stimulation through [Ca2+] mobilization was occurred. PKC isozyme alpha expression was decreased compared with peripheral blood T cells.
Yamasaki
H
H
First Department of Internal Medicine, Kumamoto University School of Medicine.
Furuie
H
H
Ando
M
M
D000954:Antigens, Surface / Q000502:physiology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D016516:CD4-CD8 Ratio; D002118:Calcium / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism; D012507:Sarcoidosis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D016207:Cytokines; D011493:Protein Kinase C; D002118:Calcium