[A comparative study of the interaction of steroid preparations with the lymphocytes].
In in vivo and in vitro experiments, androgen anabolic steroid agents (testosterone, methandrostenolone) and dexamethasone showed a dose-dependent inhibition of PHA-stimulated proliferation of C57BL/6 mice thymocytes. The phytoecdysteroidal anabolic steroid ecdystene failed to inhibit thymocytic proliferation. The competitive radioligand analysis was used to show that testosterone and methandrostenolone displace the androgenic steroid mibolerone from lymphocytes. The findings provide evidence that lymphocytes have specific binding sites for androgen-anabolic steroids.
Sergeev
P V
PV
Semeĭkin
A V
AV
Dukhanin
A S
AS
Stonans
E Iu
EIu
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008696:Methandrostenolone / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011987:Receptors, Steroid / Q000187:drug effects; D013256:Steroids / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology*
D011987:Receptors, Steroid; D013256:Steroids; D013739:Testosterone; C088647:ecdystene; D003907:Dexamethasone; D008696:Methandrostenolone
Sravnitel'noe izuchenie vzaimodeĭstviia steroidnykh preparatov s limfotsitami.