Interleukin 1 (IL-1 alpha and IL-1 beta) induces differentiation/activation of B cell chronic lymphoid leukemia cells.
The effect of interleukin 1 (IL-1) was studied on leukemic cells from 12 patients with B cell chronic lymphoid leukemias including two cases of hairy cell leukemia (HCL), two cases of HCL-variant (HCL-V), one case of prolymphocytic leukemia (PLL), and seven cases of chronic lymphocytic leukemia (CLL). In most cases, IL-1 induced differentiation characterized by increments of sIg gamma+, sIg mu+ and PCA-1+ cells, and a decrement of CD5+ cells, and activation characterized by increments of CD23+ and HC2+ cells, but induced the proliferation of leukemic cells only in two HCL-V cases. Among these effects, increment of sIg+ cells was observed more frequently in non-CLL (4/5 cases) than in CLL (2/7 cases), and increments of sIg gamma+, CD23+ and PCA-1+ cells were induced more frequently by IL-1 beta than by IL-1 alpha. These results suggest that IL-1, especially IL-1 beta, plays a significant role in the differentiation and activation of leukemic cells, but has only a minor role as an extrinsic/leukemic cells in B cell chronic lymphoid leukemias, particularly those with more mature cells such as PLL and HCL.
Takeuchi
H
H
First Department of Pathology, Saitama Medical School, Japan.
Katayama
I
I
D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D007375:Interleukin-1