Arterial blood pressure immediately after thermal injury: the role of anesthesia.
Mean arterial blood pressure was measured in anesthetized rats. The duration that the rats were under anesthesia with ether or methohexital was brief, and the animals were allowed to awaken early after injury. Three hemodynamic measurements were compared: (1) lowest mean arterial blood pressure, (2) duration at lowest mean arterial blood pressure, and (3) time to recover initial mean arterial blood pressure. In these studies the anesthetic agents reduced mean arterial blood pressure by 36%, recovering to normal pressures within 24 to 39 minutes. During the hemodynamic observation period, no significant additional hemodynamic effects as a result of the thermal injury were seen. Administration of resuscitation fluid did not significantly affect hemodynamics during the observation period in this study. These studies demonstrate that anesthesia dominates the short-term cardiovascular effects of thermal injury, and therefore caution is required in the interpretation of acute cardiovascular effects immediately after thermal injuries with patients under general anesthesia.
Trop
M
M
Childrens and Surgical Services, Massachusetts General Hospital, Boston 02114.
Carter
E A
EA
Schiffrin
E J
EJ
Tompkins
R G
RG
D000768:Anesthesia, General / Q000009:adverse effects*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002056:Burns / Q000503:physiopathology*; D003864:Depression, Chemical; D004987:Ethers / Q000009:adverse effects; D005260:Female; D008723:Methohexital / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains
D004987:Ethers; D008723:Methohexital