title: Mosquito repellency & toxicity of isomeric N, N-diethyltolylacetamides.
abstract: Three isomers of N, N-diethyltolylacetamides were synthesized and evaluated against Aedes aegypti and Culex quinquefasciatus for repellency and with mice for LD50, as an indicator of mammalian toxicity. Of these, N, N-diethyl-p-tolylacetamide (DEPTA) showed comparatively better repellency against C. quinquefasciatus. All the compounds showed higher repellency against C. quinquefasciatus than Ae. aegypti. In addition, N, N-diethyl-m-tolylacetamide (DEMTA) was found to be least toxic to mice.
authors.affiliation: Defence R & D Establishment, Gwalior.
authors.forename: N
authors.initials: N
authors.lastname: Sikder
authors.forename: N
authors.initials: N
authors.lastname: Gopalan
authors.forename: S
authors.initials: S
authors.lastname: Prakash
authors.forename: V K
authors.initials: VK
authors.lastname: Vinod
authors.forename: S S
authors.initials: SS
authors.lastname: Rao
authors.forename: K M
authors.initials: KM
authors.lastname: Rao
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000330:Aedes; D000818:Animals; D003465:Culex; D005260:Female; D007302:Insect Repellents / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D007302:Insect Repellents