[Lipid peroxidation during synaptosome depolarization].
The activity of lipid peroxidation in synaptosomes obtained from rat cerebral cortex during different forms of depolarisation has been studied. Depolarization was induced by synaptosomes' electrostimulation, addition of 33 mM KCl or 1 mM ouabain. Such depolarized synaptosomes were used as a model of nerve ending from epileptic focus. It has been shown that at all cases synaptosomes depolarization was accompanied with increasing in lipid peroxidation products level.
Nikushkin
E V
EV
Kucherianu
V G
VG
D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D009411:Nerve Endings / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000502:physiology*; D013858:Thiobarbiturates / Q000378:metabolism
D013858:Thiobarbiturates; C029684:thiobarbituric acid
Perekisnoe okislenie lipidov pri depoliarizatsii sinaptosom.