title: Reduction of urinary 1-hydroxypyrene excretion in coke-oven workers exposed to polycyclic aromatic hydrocarbons due to improved hygienic skin protective measures.
abstract: The effect of hygienic skin protective measures on the internal exposure to polycyclic aromatic hydrocarbons (PAHs) was studied in 13 coke-oven workers. The study took place over 2 consecutive weeks. In 1 week the subjects worked under the normal circumstances, in the other week extra hygienic skin protective measures were instituted: laundered working clothes and a new pair of gloves before each 8-h work shift, and the washing both of the hands and of the face before each break. Biological monitoring was undertaken to measure the effect of the extra hygienic measures on the urinary 1-hydroxypyrene excretion, which is a measure of the internal PAH exposure. The increase of the urinary 1-hydroxypyrene concentration over the 4-day workweek was on average 37% lower when extra hygienic measures were taken, being 1.3 instead of 2.3 mumole 1-hydroxypyrene per mole creatinine (P = 0.03, N = 13). This study demonstrates that simple hygienic skin protective measures result in a significant reduction of the internal PAH exposure.
authors.affiliation: Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: VanRooij
authors.forename: M M
authors.initials: MM
authors.lastname: Bodelier-Bade
authors.forename: P M
authors.initials: PM
authors.lastname: Hopmans
authors.forename: F J
authors.initials: FJ
authors.lastname: Jongeneelen
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000652:urine*; D000704:Analysis of Variance; D015415:Biomarkers / Q000652:urine; D002617:Chemical Industry; D003077:Coke; D017575:Gloves, Protective; D006801:Humans; D009153:Mutagens / Q000032:analysis*; D016273:Occupational Exposure / Q000517:prevention & control*; D011083:Polycyclic Compounds / Q000493:pharmacokinetics*; D011721:Pyrenes / Q000032:analysis*; D012869:Skin Absorption
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D003077:Coke; D009153:Mutagens; D011083:Polycyclic Compounds; D011721:Pyrenes; C033146:1-hydroxypyrene