title: [Effect of preliminary administration of phenobarbital on the toxicity of GABA-lytics in mice].
abstract: The toxicity of picrotoxin bicuculline, but not of 3-mercaptopropionic acid decreased in mice pretreated during three days with phenobarbital and benzonal. The antidotal effectiveness of diazepam by picrotoxin and bicuculline exposure increased significantly. It has been suggested, that the modulation of detoxication systems may be the cause of increased tolerance against GABA-antagonists.
authors.forename: A I
authors.initials: AI
authors.lastname: Golovko
authors.forename: G A
authors.initials: GA
authors.lastname: Sofronov
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000633:toxicity*; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology*; D001640:Bicuculline / Q000037:antagonists & inhibitors / Q000633:toxicity*; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology*; D010852:Picrotoxin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D015097:3-Mercaptopropionic Acid; D000931:Antidotes; D001463:Barbiturates; D001640:Bicuculline; D003975:Diazepam; D010634:Phenobarbital; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid; C002915:benzobarbital
vernacular_title: Vliianie predvaritel'nogo vvedeniia fenobarbitala na toksichnost' GAMK-litikov u mysheĭ.