title: Aortic dissection. Prevalence, cause, and results of late reoperations.
abstract: From January 1977 to September 1992, 143 patients underwent an emergency operation for type A acute aortic dissection. Because of the location of the intimal tear, the replacement of the ascending aorta was extended to the transverse arch in 42 patients (29.3%). One hundred ten patients (78%) survived the operation. During the same period, 32 patients had to be reoperated on once (n = 24) twice (n = 6), or three times (n = 2) for a total of 42 reoperations. Nineteen patients had had the initial repair in our institution, and 13 had been operated on elsewhere. Reoperation was indicated for aortic valve disease (n = 4), recurring dissection (n = 7) threatening aneurysmal evolution of a persisting dissection (n = 28), or false aneurysm (n = 3). The redo procedure involved the aortic root and/or ascending aorta in 15 cases (group I), the transverse arch alone in 7 cases (group II), the transverse arch and the descending aorta or the descending aorta alone in 10 cases (group III), or the thoracoabdominal aorta in 10 cases (group IV). The risk factors for reoperation have been analyzed in the 110 survivors initially operated on in our institution. Seven of 18 patients with Marfan's syndrome (38.8%) versus 12 of 92 without Marfan's syndrome (13%) were reoperated on (p = 0.023). None of the 30 patients surviving arch replacement at initial repair required a reoperation, versus 19 of 80 (23.7%) patients surviving a replacement limited to the ascending aorta (p = 0.013). The overall mortality rate of reoperation was 21.8% (7/32) with a risk of 16.6% (7/42) at each procedure (group I, 13.3%; group II, 0%; group III, 20%; group IV, 30%). Hospital mortality was influenced by emergency operation (5/10) (p < 0.005) and thoracoabdominal replacement (3/10) (p < 0.035). The late survivals after reoperation are 65.1% +/- 17.6% at 1 year and 55% +/- 19.63% at 5 years (Kaplan-Meier, confidence interval 95%). The late survivals, after the initial repair, of the patients undergoing reoperation are 89.6% +/- 11.0%, 79.3% +/- 14.7%, 53.9% +/- 18.1%, and 35.9% +/- 21.8% at 1, 5, 10, and 12 years, respectively. In conclusion, aortic dissection is an evolving process that may require one or several reoperations after the initial repair. At initial emergency operation, the resection of the entry site, when located on or extending to the transverse arch, has reduced the risk of reoperation, in our experience. Elective reoperation must be considered before the occurrence of complications, especially in patients with Marfan's syndrome.(ABSTRACT TRUNCATED AT 400 WORDS)
authors.affiliation: Service de Chirurgie Cardio-vasculaire, Hôpital Foch, Universite de Paris-Ouest, Suresnes, France.
authors.forename: J E
authors.initials: JE
authors.lastname: Bachet
authors.forename: J L
authors.initials: JL
authors.lastname: Termignon
authors.forename: G
authors.initials: G
authors.lastname: Dreyfus
authors.forename: B
authors.initials: B
authors.lastname: Goudot
authors.forename: L
authors.initials: L
authors.lastname: Martinelli
authors.forename: A
authors.initials: A
authors.lastname: Piquois
authors.forename: D
authors.initials: D
authors.lastname: Brodaty
authors.forename: C
authors.initials: C
authors.lastname: Dubois
authors.forename: P
authors.initials: P
authors.lastname: Delentdecker
authors.forename: D
authors.initials: D
authors.lastname: Guilmet
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D004338:Drug Combinations; D005557:Formaldehyde; D005780:Gelatin; D017052:Hospital Mortality; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D012086:Reoperation / Q000401:mortality / Q000706:statistics & numerical data; D012118:Resorcinols; D012307:Risk Factors; D016019:Survival Analysis; D014014:Tissue Adhesives
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin