title: [Treatment of severe forms of Langerhans cell histiocytosis].
abstract: Langerhans cell histiocytosis is a non malignant disorder of immune regulation. Patients with multisystem disease and organ dysfunction are considered to have a poor prognosis, and particularly children younger than 2 years of age. Clinical trials using human alpha-interferon, cyclosporine A and bone marrow transplantation have been reported recently.
authors.affiliation: Service d'hématologie pédiatrique et de transplantation de moelle osseuse, hôpital Debrousse, Lyon, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Bertrand
mesh_terms: D016026:Bone Marrow Transplantation; D016572:Cyclosporine / Q000627:therapeutic use; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D016898:Interferon-alpha; D016572:Cyclosporine
vernacular_title: Traitement des formes sévères d'histiocytose langerhansienne.