title: Granulomatous slack skin.
abstract: Granulomatous slack skin is a form of cutaneous lymphoma with an indolent but relentless course. It is characterized by circumscribed areas of pendulous lax skin that contain clonal infiltrates of helper T-cells, which infiltrate the epidermis in a manner similar to that of mycosis fungoides and attract a granulomatous component that mediates massive dermal elastolysis. The evolution of Hodgkin's disease occurs in some cases. There is no known curative treatment, but surgery, radiation therapy, systemic corticosteroids, and chemotherapy have slowed the progression of some lesions.
authors.affiliation: Dermatopathology Section, University of California, San Francisco.
authors.forename: P E
authors.initials: PE
authors.lastname: LeBoit
mesh_terms: D003937:Diagnosis, Differential; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000473:pathology; D009182:Mycosis Fungoides / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology