title: [The experimental and clinical use of neprolizin in thermal burns of the skin].
abstract: Morphological skin changes within the focus of lesion and in the perilesional area are studied against the background of local application of the Bulgarian enzyme preparation Neprolyzin. The experimentally induced injury includes thermal burn, mechanical crushing (conquassatio), and combination of the two. The drug is administered immediately after the trauma, or on the fourth post-injury day, with the studies performed after 4-day-long treatment. In the clinical trial Neprolyzin is applied within 3 to 4 days of a third-degree burn. In conclusion, it is stressed that Neprolyzin should be applied immediately after a thermal burn, it should not be used in handling a mechanical crush injury, whereas in the event of associated trauma it should be used on the fourth post-injury day. The clinical assessment points to the necessity of local anesthesia during application of the drug, or analgesics up to one hour after the dressing.
authors.forename: K
authors.initials: K
authors.lastname: Troshev
authors.forename: D
authors.initials: D
authors.lastname: Markov
authors.forename: P
authors.initials: P
authors.lastname: Nedkov
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D003646:Debridement / Q000379:methods*; D004338:Drug Combinations; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D057487:Enzyme Therapy; D004798:Enzymes; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D004798:Enzymes; C088485:Neprolyzin
vernacular_title: Eksperimentalno i klinichno prilozhenie na neprolizin pri termichni izgarianiia na kozhata.