title: Ochrindoles A-D: new bis-indolyl benzenoids from the sclerotia of Aspergillus ochraceus NRRL 3519.
abstract: Four new prenylated bis-indolyl benzenoid metabolites (ochrindoles A-D; 1-4) were isolated from antiinsectan organic extracts of the sclerotia of Aspergillus ochraceus (NRRL 3519). The structures of these compounds were determined primarily through HMBC, selective INEPT, and NOESY experiments. These compounds displayed moderate activity in feeding assays against the corn earworm Helicoverpa zea and the driedfruit beetle Carpophilus hemipterus. Compounds 1-4 also exhibited activity against Gram-positive bacteria.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City 52242.
authors.forename: F S
authors.initials: FS
authors.lastname: de Guzman
authors.forename: D R
authors.initials: DR
authors.lastname: Bruss
authors.forename: J M
authors.initials: JM
authors.lastname: Rippentrop
authors.forename: K B
authors.initials: KB
authors.lastname: Gloer
authors.forename: J B
authors.initials: JB
authors.lastname: Gloer
authors.forename: D T
authors.initials: DT
authors.lastname: Wicklow
authors.forename: P F
authors.initials: PF
authors.lastname: Dowd
mesh_terms: D000818:Animals; D001235:Aspergillus ochraceus / Q000378:metabolism*; D001412:Bacillus subtilis / Q000187:drug effects; D003864:Depression, Chemical; D005247:Feeding Behavior / Q000187:drug effects; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D007313:Insecta; D007306:Insecticides / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D007211:Indoles; D007306:Insecticides