The in vivo effect of ellipticine analogues on the blood concentration of Friend virus: a murine model for studying anti-HIV drugs.
The viremia of a mouse carrying a murine retrovirus, the Friend virus, was taken as a model for screening drugs which could be active on the human HIV retrovirus. Ellipticine and two of its analogues injected ip at appropriate doses drastically reduced the viremia of the Friend virus-injected mice, as measured by transfer of their serum on day 8 of the treatment to secondary recipients and numeration, in the spleens of the latter, of the foci the remaining virus had induced. Since phase I and II trials have already been published (for leukemia treatment), the efficacy of those drugs on HIV-1 positive AZT-resistant patients can be tested directly.
Mathé
G
G
Institut du cancer et d'immunologie, Hôpital Suisse de Paris, Issy-les-Moulineaux, France.
Chenu
E
E
Bourut
C
C
Orbach-Arbouys
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000818:Animals; D001769:Blood / Q000382:microbiology; D004195:Disease Models, Animal; D004611:Ellipticines / Q000494:pharmacology*; D005622:Friend murine leukemia virus / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D015215:Zidovudine / Q000494:pharmacology
D004611:Ellipticines; D015215:Zidovudine