[Localized or systemic amyloidosis? Value and limitations of Iodine-123 labelled amyloid P component scintigraphy, role of biopsy of minor salivary glands].
We evaluated the value of serum amyloid P component scintigraphy (123I-SAP) and labial salivary gland biopsy in four patients with apparently localized amyloidosis. One patient had pharyngeal amyloidosis, the second laryngeal amyloidosis, the third retro-ocular amyloidosis and the fourth had carpal tunnel syndrome. Three patients (no 2, no 3, no 4) have abnormal whole body retention of 123I-SAP and positive labial salivary gland biopsy for amyloidosis. Only the first patient had effectively localized amyloidosis and local treatment was sufficient. Melphalan was given to the patients no 2 and no 3, colchicine was given to the patient no 4. Labial salivary gland biopsy and 123I-SAP scintigraphy may give positive argument for the diagnosis of systemic amyloidosis in patients with apparently localized amyloidosis.
Hachulla
E
E
Service de médecine interne, hôpital Claude-Huriez, CHRU, Lille, France.
Wechsler
B
B
Deveaux
M
M
Godeau
P
P
Hatron
P Y
PY
Devulder
B
B
Janin
A
A
Marchandise
X
X
D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D012470:Salivary Glands, Minor / Q000473:pathology*; D000683:Serum Amyloid P-Component
D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component
Amylose localisée ou systémique? Intérêt et limites de la scintigraphie au composant amyloïde P marqué à l'iode 123, place de la biopsie de glandes salivaires accessoires.