title: [Changes in the cellular proliferation of the healthy mucosa in patients with colorectal cancer].
abstract: OBJECTIVE
  To analyze differences in the proliferative pattern of normal mucosa between patients with colorectal cancer and healthy subjects.
  
  
  METHODS
  By using flow cytometry we examined the proliferative pattern (Proliferative Index and S-Phase) in samples of normal mucosa from 34 patients operated on for colorectal cancer at our hospital and from 14 healthy subjects as a control group.
  
  
  RESULTS
  All examined samples were diploid. The Proliferative Index and S-Phase in the Cancer Group were significantly higher than in the Control Group (16.7 +/- 5.9 vs 11.4 +/- 4, p < 0.003, and 11.9 +/- 3.9 us 6.6 +/- 3 p < 0.0004).
  
  
  CONCLUSIONS
  These findings provide evidence for an altered proliferative pattern in the healthy colonic mucosa of patients with colorectal cancer.
authors.affiliation: Servicio de Cirugía General, Consorci Sanitari de Mataró.
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: C
authors.initials: C
authors.lastname: Mallofre
authors.forename: T
authors.initials: T
authors.lastname: Soler
authors.forename: R
authors.initials: R
authors.lastname: Diloy
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: J
authors.initials: J
authors.lastname: Suñol
authors.forename: J
authors.initials: J
authors.lastname: Barja
authors.forename: L
authors.initials: L
authors.lastname: Hidalgo
authors.forename: M
authors.initials: M
authors.lastname: Ubach
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
vernacular_title: Alteraciones de la proliferación celular de la mucosa sana en pacientes con cáncer colorrectal.