Photoleukomelanodermatitis (Kobori) induced by afloqualone.
We reported a case of photoleukomelanodermatitis (Kobori) type drug eruption due to afloqualone (Arofuto). The patient was given afloqualone and imipramine hydrochloride (Chrytemin) for cervical spondylosis from November of 1990. Edematous erythema with slight itching appeared on the sun-exposed areas in December of 1990. As drug eruption was suspected, drugs were ceased, and the cutaneous lesions almost disappeared but pigmentations and depigmentations developed in spots in sun-exposed areas in March of 1991. Photopatch and oral challenge tests were positive.
Ishikawa
T
T
Department of Dermatology, Gunma University School of Medicine, Maebashi, Japan.
Kamide
R
R
Niimura
M
M
D000368:Aged; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D010859:Pigmentation Disorders / Q000139:chemically induced*; D011799:Quinazolines / Q000009:adverse effects*
D009125:Muscle Relaxants, Central; D011799:Quinazolines; C033541:afloqualone