Cortical and subcortical JC virus infection: two unusual cases of AIDS associated progressive multifocal leukoencephalopathy.
Two patients with AIDS and progressive neurological syndromes had necropsies that identified JC virus infection of the cerebral or cerebellar cortex. The unusual presentation of progressive multifocal leukoencephalopathy with grey matter involvement and normal cerebral imaging is discussed.
Sweeney
B J
BJ
Department of Neurology, University College London Medical School, Middlesex Hospital, UK.
Manji
H
H
Miller
R F
RF
Harrison
M J
MJ
Gray
F
F
Scaravilli
F
F
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D000328:Adult; D001706:Biopsy; D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D002525:Cerebellar Cortex; D002540:Cerebral Cortex; D017809:Fatal Outcome; D015497:HIV-1; D006801:Humans; D007577:JC Virus; D007968:Leukoencephalopathy, Progressive Multifocal / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D030361:Papillomavirus Infections / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D014412:Tumor Virus Infections / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy