Cytodiagnosis of neoplastic metastases to the liver. Immunocytochemical studies.
Differential diagnosis of neoplastic metastases to the liver encounters difficulties associated with the presence mainly of metastasized adenocarcinomas characterized by a similar cytological pattern. Determination of a metastatic site of origin only from routinely stained cytological smears is frequently impossible. Therefore it was attempted to employ immunocytochemical studies in differentiation of metastatic neoplasms using monoclonal antibodies against cytokeratin 7 and 20 and against colon specific antigen and pancreatic specific antigen. The results of the present study show that in a group of anaplastic small-cell carcinomas, squamous cell carcinomas and hepatocellular carcinomas immunocytochemistry does not add significant information on their diagnosis. In contrast, with respect to adenocarcinomas the method is fundamental in limiting the range of search for the metastatic site of origin and thus shortens the diagnostic procedure.
Tomaszewska
R
R
Department of Clinical and Experimental Pathomorphology Jagellonian University Medical College, Kraków.
Stachura
J
J
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology* / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology* / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*