title: Dynamic magnetic resonance imaging for the evaluation of synovitis in patients with rheumatoid arthritis.
abstract: OBJECTIVE
  To investigate whether the findings of magnetic resonance imaging (MRI) reflect rheumatoid synovitis.
  
  
  METHODS
  Dynamic imaging enhanced with gadolinium-diethylenetriamine pentaacetic acid was performed on 10 affected knees of 9 patients with rheumatoid arthritis. Changes in signal intensity were correlated with pathologic findings in synovial biopsy specimens obtained during total knee arthroplasty.
  
  
  RESULTS
  Enhancement was greater in regions with a higher degree of fibrin exudation, cellular infiltration, villous hypertrophy, vascular proliferation, and granulation formation.
  
  
  CONCLUSIONS
  Dynamic MRI can be used for assessing local disease activity in rheumatoid synovium.
authors.affiliation: Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tamai
authors.forename: M
authors.initials: M
authors.lastname: Yamato
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: W
authors.initials: W
authors.lastname: Ohno
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000473:pathology; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007267:Injections; D007719:Knee Joint; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000150:complications / Q000175:diagnosis*
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA