[Aggressive role of lysosomal enzymes in gastric ulceration].
Administration of lysosomes and lysosome enzymes into the submucous base of intact rats' stomachs did not result in ulceration. Premedication by histamine, serotonin (combined and separated) and ACTH did not increase sensibility of mucous membrane to lysosome enzymes. Prednisolone-premedication provoked the decrease of mucous membrane resistance to free lysosome enzymes and appearance of ulcerative lesions in the point of enzyme applications. Free lysosome enzymes are able to produce ulcerative lesions. This process is going on with the participation of prednisolone.
Amirov
N Sh
NSh
Antonov
D V
DV
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000818:Animals; D001679:Biogenic Amines / Q000627:therapeutic use; D006632:Histamine / Q000627:therapeutic use; D008247:Lysosomes / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats; D012701:Serotonin / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy / Q000201:enzymology*
D001679:Biogenic Amines; D012701:Serotonin; D006632:Histamine; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone; D010447:Peptide Hydrolases
Agressivnaia rol' lizosomnykh fermentov pri iazvoobrazovanii v zheludke.