[Molecular mechanisms of regulating human erythropoiesis--theoretic basis--new treatment strategies].
In this paper the regulation of erythropoiesis is reviewed. The production of red blood cells is discussed at the levels of the genes regulating cell proliferation, the signal transduction proteins, and the stimulatory and inhibitory cytokines. The data are presented within a framework of potential clinical applications. New strategies for the treatment of red blood cell disorders are also reviewed, including therapy with recombinant cytokines, and the application of immuno-adhesins, fusion proteins and antisense oligodeoxynucleotides.
Ratajczak
M Z
MZ
Pracowni Hematologii Molekularnej Zakładu Patologii, Uniwersytetu Pennsylwania, Filadelfia 19104.
D000818:Animals; D002455:Cell Division / Q000235:genetics; D016207:Cytokines / Q000502:physiology / Q000627:therapeutic use; D004920:Erythropoiesis / Q000502:physiology*; D006402:Hematologic Diseases / Q000628:therapy; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology
D016207:Cytokines; D011994:Recombinant Proteins
Mechanizmy molekularne regulujace ludzka erytropoeze--podstawy teoretyczne--nowe strategie lecznicze.