title: Dose related remineralization using intraoral fluoride-releasing devices in situ.
abstract: Dose-related remineralization of enamel lesions was studied in situ. Enamel specimens with subsurface lesions were mounted on lower molars bilaterally and exposed to five regimens: (A) control with a F-free dentifrice three times daily; (B) NaF dentifrice brushed three times daily; (C) fluoride-releasing device (FRD; 0.07 mg F/day release rate) plus F-free dentifrice; (D) FRD (0.232 mg F/day) plus F-free dentifrice, F/day and (E) FRD (0.232 mg/F/day) plus NaF dentifrice. Resting and stimulated saliva samples were obtained for salivary flow and F content determinations. Twenty-eight subjects participated in this double-blind, random-assignment crossover study. After 50 days the enamel specimens were recovered, sectioned, microradiographed, and scanned with image analysis. Regimens D and E demonstrated approximately 30% additional remineralization as compared with to controls, and regimens B and C showed 13.7 and 10.5% increased remineralization as compared with to controls. The increased remineralization of the regimens generally paralleled the increase in salivary F and clearly demonstrated a dose-related response which was some threefold in relation to release rate, salivary F, and percent remineralization.
authors.affiliation: School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
authors.forename: B E
authors.initials: BE
authors.lastname: Cain
authors.forename: R E
authors.initials: RE
authors.lastname: Corpron
authors.forename: C L
authors.initials: CL
authors.lastname: Fee
authors.forename: D S
authors.initials: DS
authors.lastname: Strachan
authors.forename: C J
authors.initials: CJ
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004245:DMF Index; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000295:instrumentation / Q000379:methods*; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D014100:Toothpastes; D012969:Sodium Fluoride; D005459:Fluorides