title: Successful use of all-trans retinoic acid in acute promyelocytic leukaemia presenting during the second trimester of pregnancy.
abstract: The development of acute leukaemia in pregnancy is a rare event, with an estimated incidence of 0.9-1.2 cases per 100,000 per year and with the majority of cases occurring in the second and third trimesters. We report a case of acute promyelocytic leukaemia (APL) developing during the second trimester of pregnancy which was successfully treated with all-trans retinoic acid (ATRA) resulting in a complete morphological remission.
authors.affiliation: Department of Haematology, North Staffordshire Hospital, Stoke-on-Trent.
authors.forename: P
authors.initials: P
authors.lastname: Harrison
authors.forename: P
authors.initials: P
authors.lastname: Chipping
authors.forename: G A
authors.initials: GA
authors.lastname: Fothergill
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin