Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale).
The dried rhizomes of Indonesian ginger, Zingiber officinale, were investigated for antirhinoviral activity in the plaque reduction test. Fractionation by solvent extraction, solvent partition, and repeated chromatography guided by bioassay, allowed the isolation of several sesquiterpenes with antirhinoviral activity. The most active of these was beta-sesquiphellandrene [2] with an IC50 of 0.44 microM vs. rhinovirus IB in vitro.
Denyer
C V
CV
Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, UK.
Jackson
P
P
Loakes
D M
DM
Ellis
M R
MR
Young
D A
DA
D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012229:Rhinovirus / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D012717:Sesquiterpenes