title: Comparative chromosome painting discloses homologous segments in distantly related mammals.
abstract: Comparative chromosome painting, termed ZOO-FISH, using DNA libraries from flow sorted human chromosomes 1, 16, 17 and X, and mouse chromosome 11 discloses the presence of syntenic groups in distantly related mammalian orders ranging from primates (Homo sapiens), rodents (Mus musculus), even-toed ungulates (Muntiacus muntjak vaginalis and Muntiacus reevesi) and whales (Balaenoptera physalus). These mammalian orders have evolved separately for 55-80 million years (Myr). We conclude that ZOO-FISH can be used to generate comparative chromosome maps of a large number of mammalian species.
authors.affiliation: Institute of Human Genetics and Anthropology, Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Scherthan
authors.forename: T
authors.initials: T
authors.lastname: Cremer
authors.forename: U
authors.initials: U
authors.lastname: Arnason
authors.forename: H U
authors.initials: HU
authors.lastname: Weier
authors.forename: A
authors.initials: A
authors.lastname: Lima-de-Faria
authors.forename: L
authors.initials: L
authors.lastname: Frönicke
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure*; D015342:DNA Probes; D003670:Deer / Q000235:genetics; D015186:Hominidae / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008322:Mammals / Q000235:genetics*; D051379:Mice / Q000235:genetics; D010802:Phylogeny; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014907:Whales / Q000235:genetics
chemical_list: D015342:DNA Probes