title: Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits.
abstract: We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. Immunofluorescence tests showed intercellular IgA-kappa deposits in the upper portion of the lesional epidermis and circulating IgA-kappa anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-kappa paraprotein produced by myeloma cells.
authors.affiliation: Department of Dermatology, Kanazawa University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takata
authors.forename: M
authors.initials: M
authors.lastname: Inaoki
authors.forename: M
authors.initials: M
authors.lastname: Shodo
authors.forename: T
authors.initials: T
authors.lastname: Hirone
authors.forename: H
authors.initials: H
authors.lastname: Kaya
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D012867:Skin / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains