title: Polyethylene glycolated interleukin-2 as maintenance therapy for acute myelogenous leukemia in second remission.
abstract: Seven patients in second complete remission of acute myeloid leukemia (AML) aged 19-65 years were treated with polyethylene glycolated interleukin-2 (PEG IL-2), 1 x 10(6) U/M2 IV weekly as the sole postremission therapy. Second remission duration was in the range of 4-49+ months, and three patients had a second remission duration substantially longer than their first (6, 21+, and 42+ months). The results suggest that PEG IL-2 may prolong second remission duration in AML and that a prospective randomized study designed to test that idea is warranted.
authors.affiliation: Albert Einstein Cancer Center/Department of Oncology, Montefiore Medical Center, Bronx, New York 10467-2490.
authors.forename: P H
authors.initials: PH
authors.lastname: Wiernik
authors.forename: J P
authors.initials: JP
authors.lastname: Dutcher
authors.forename: M
authors.initials: M
authors.lastname: Todd
authors.forename: G
authors.initials: G
authors.lastname: Caliendo
authors.forename: L
authors.initials: L
authors.lastname: Benson
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols
chemical_list: D007376:Interleukin-2; C067245:interleukin-2, polyethylene glycol-modified; D011092:Polyethylene Glycols