Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate.
The in vitro activity against herpes simplex virus type 1 of 3-methyl-but-2-enyl caffeate isolated from poplar buds or prepared by synthesis was investigated. Under conditions of one or multiple multiplication cycles, this compound, which is a minor constituent of propolis, was found to reduce the viral titer by 3 log10, and viral DNA synthesis by 32-fold.
Amoros
M
M
Laboratoire de Pharmacognosie et Mycologie.
Lurton
E
E
Boustie
J
J
Girre
L
L
Sauvager
F
F
Cormier
M
M
D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002109:Caffeic Acids / Q000302:isolation & purification* / Q000494:pharmacology; D015342:DNA Probes; D004279:DNA, Viral / Q000096:biosynthesis; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009693:Nucleic Acid Hybridization; D010946:Plants, Medicinal / Q000737:chemistry*; D011429:Propolis / Q000494:pharmacology*
D000998:Antiviral Agents; D002109:Caffeic Acids; D015342:DNA Probes; D004279:DNA, Viral; C054126:1,1-dimethylallyl caffeic acid ester; D011429:Propolis