[Guanfu base A inhibit the post-infarction ventricular arrhythmias in dogs].
Harris tow-stage left anterior coronary ligation was performed in anesthetized dogs. After twenty hours, severe ventricular arrhythmias were recorded under conscious state. Cumulative intravenous injections of guanfu base A, a new alkaloid isolated from the tuber of Aconitum coreanum in China, from 10 to 40 mg.kg-1 produced remarkable antiarrhythmic effect lasting over 30 min and a moderate reduction of heart rate. The P-R interval, QRS complex and Q-T interval of the sinus rhythm were not significantly altered. The antiarrhythmic potency of guanfu base A in this model was found to be about one third that of quinidine.
Wang
Y Q
YQ
Research Division of Pharmacology, China Pharmaceutical University, Nanjing.
Su
L
L
Gong
G Q
GQ
Liu
J H
JH
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D011802:Quinidine / Q000627:therapeutic use
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C040615:Guan-fu base A; D011802:Quinidine