title: [Biologically active substances in patients with hypervolemic congenital heart defects undergoing general multicomponent anesthesia].
abstract: In 95 patients with hypervolemic congenital heart diseases (42 with interventricular and interatrial septal defects, and 53 with patent ductus arteriosus) mixed venous blood levels of serotonin, histamine, adrenalin, noradrenaline, total 11-hydroxycorticosteroids were studied using spectrofluorimetry, cyclic adenosine- and guanosine-monophosphate (cAMP and cGMP), prostaglandins E+A and F2 alpha and their interaction were assessed using radioimmunoassay and correlation analysis, respectively. Before surgical treatment the patients showed higher (than in the control) concentrations of histamine, adrenalin, noradrenaline, cAMP, and cGMP, prostaglandins E+A. During anesthesia including fentanyl, morphine, diazepam, N2O:O2 in patients with heart valve defects cGMP level was increased and in patients with patent ductus arteriosus cAMP level was increased during analogous anesthesia with morphine replaced by halothane.
authors.forename: N M
authors.initials: NM
authors.lastname: Gerasimov
authors.forename: D S
authors.initials: DS
authors.lastname: Guliamov
authors.forename: T Z
authors.initials: TZ
authors.lastname: Karimova
authors.forename: O A
authors.initials: OA
authors.lastname: Belova
authors.forename: L S
authors.initials: LS
authors.lastname: Ivanova
authors.forename: L N
authors.initials: LN
authors.lastname: Nam
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001774:Blood Chemical Analysis; D001810:Blood Volume; D002648:Child; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006343:Heart Septal Defects / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D014680:Veins
vernacular_title: Biologicheski aktivnye veshchestva u bol'nykh s gipervolemicheskimi vrozhdennymi porokami serdtsa v usloviiakh obshcheĭ mnogokomponentnoĭ anestezii.