title: Pulsatile gonadotropin releasing hormone (GnRH)--treatment for hypothalamic amenorrhoea causing infertility.
abstract: Thirty women with hypothalamic amenorrhoea and infertility were treated with pulsatile GnRH s.c. without monitoring with estradiol and ultrasonography. Ovulation rate per patient was 93%. Ovulation rate per cycle was 90%. Pregnancy rate per ovulatory cycle 30%. Miscarriage rate 18.5%. 23 children were born including one set of twins. No serious side effects were recorded.
authors.affiliation: Specialist Open-care Unit of Obstetrics and Gynecology, Uppsala, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Skarin
authors.forename: M
authors.initials: M
authors.lastname: Ahlgren
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications*; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D010062:Ovulation Induction / Q000379:methods; D011673:Pulsatile Flow; D016896:Treatment Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone