title: Sigmoid shape of the oxygen equilibrium curve and the P50 of human hemoglobin.
abstract: The fractional saturation of hemoglobin with oxygen was plotted against P/P50 and the slope of the abscissa at 1 was calculated for 38 OEC data sets of human Hb A. There was a linear correlation between the slope and the Hill coefficient (nmax), and the slope was about one-fourth that of nmax. This implies that the slope of the abscissa at 1 of Y vs P/P50 plot can provide information about the magnitude of cooperativity in hemoglobin oxygen binding.
authors.affiliation: Department of Biology, Faculty of Science, Niigata University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: G
authors.initials: G
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Ishigaki
mesh_terms: D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008962:Models, Theoretical; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism*; D010313:Partial Pressure
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D010100:Oxygen