title: Ubiquitins revisited: further examples of within- and between-locus concerted evolution.
abstract: Ubiquitin genes provide a model for studying the effects of concerted evolution on the evolution of a family of short repeated sequences. Previous work has demonstrated the occurrence of within-locus concerted evolution and raised the question of the effectiveness of between-locus concerted evolution for ubiquitin repeats. In this study comparative analysis of additional nucleotide sequences of ubiquitin tandem repeats provides further details of within-locus concerted evolution. Moreover, the availability of multiple polyubiquitin loci and ubiquitin fusion loci within a species makes possible the detection of between-locus concerted evolution. These data indicate that concerted evolution is an effective force for homogenizing repeats between, as well as within, loci.
authors.affiliation: Department of Biology, Yale University, New Haven, Connecticut 06511.
authors.forename: Y
authors.initials: Y
authors.lastname: Tan
authors.forename: S T
authors.initials: ST
authors.lastname: Bishoff
authors.forename: M A
authors.initials: MA
authors.lastname: Riley
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003001:Cloning, Molecular; D005785:Gene Conversion; D006801:Humans; D005810:Multigene Family; D011072:Poly U / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D014452:Ubiquitins / Q000235:genetics*
chemical_list: D014452:Ubiquitins; D011072:Poly U