[Adaptation to periodic hypoxia decreases vasoconstrictor and increases vasodilator responses of resistant arteries].
Adaptation to intermittent hypoxia resulted in reduced vasoconstrictor responses of rat tail artery elicited by sympathetic nerve stimulation due to desensitization of alpha- and activation beta 2-adrenoceptors. Endothelium-dependent relaxation was enhanced under the impact of adaptation to intermittent hypoxia. These shifts may play a part in antihypertensive effect of adaptation to hypoxia which has been proved earlier.
Mashina
S Iu
SIu
Meerson
F Z
FZ
D000109:Acetylcholine / Q000502:physiology; D000222:Adaptation, Physiological; D000818:Animals; D001158:Arteries; D004730:Endothelium, Vascular / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D010507:Periodicity; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
D018340:Receptors, Adrenergic, alpha-1; D018343:Receptors, Adrenergic, beta-2; D000109:Acetylcholine
Adaptatsiia k periodicheskoĭ gipoksii snizhaet konstriktornye i povyshaet dilatatornye reaktsii rezistivnoĭ arterii.