[Effect of combined chemotherapy against human intestinal nematode eggs].
The effect of a combination of albendazole and mebendazole was evaluated by stool examination in 7 patients with Ascaris lumbricoides eggs, 7 patients with Trichuris trichiura eggs and 9 patients with hookworm eggs. Albendazole and mebendazole were given at 300 mg and 375 mg, respectively. Both drugs were divided into 3 parts, one part b. id., and given in 1.5 days. The fecal eggs turned negative in all the patients with Ascaris infection in 3 days, while the fecal eggs were negative in all patients with Trichuris or hookworm infection in 5 days. The development rates of the eggs were remarkably lower post-treatment than pre-treatment. It was found that the ovicidal rates in human ascariasis, trichuriasis and ancylostomiasis were 98.8%, 100% and 100%, respectively on the second day following the initiation of treatment. The results showed that the worm-repelling and ovicidal effect of the combined chemotherapy was more evident.
Yang
W P
WP
Department of Parasitology, Medical College of Yangzhou University.
Shen
Y P
YP
Shao
J O
JO
Dong
K
K
Zhong
T
T
Hu
Y L
YL
Xu
Z L
ZL
D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage*; D000724:Ancylostomiasis / Q000188:drug therapy; D001196:Ascariasis / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007978:Levamisole / Q000008:administration & dosage; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage*; D008875:Middle Aged; D009332:Necatoriasis / Q000188:drug therapy; D009349:Nematode Infections / Q000188:drug therapy*; D010270:Parasite Egg Count; D014257:Trichuriasis / Q000188:drug therapy
D004338:Drug Combinations; D007978:Levamisole; D008463:Mebendazole; D015766:Albendazole