5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity.
Macor
J E
JE
Department of Medicinal Chemistry, Central Research Division, Pfizer Inc, Groton, Connecticut 06340.
Blank
D H
DH
Fox
C B
CB
Lebel
L A
LA
Newman
M E
ME
Post
R J
RJ
Ryan
K
K
Schmidt
A W
AW
Schulz
D W
DW
Koe
B K
BK
D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D018170:Sumatriptan / Q000378:metabolism / Q000494:pharmacology
D007211:Indoles; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C088802:CP 124439; D018170:Sumatriptan