[Effect of verapamil on arterial pressure and various parameters of heart contractile function in rabbits with prerenal artery hypertension when administered at various times of day].
The dynamics of arterial blood pressure and some data of cardiac contractility in rabbits with vasorenal hypertension were investigated in 4 seasons of the year. Simultaneously, the effects of verapamil on the said data were studied in rabbits with vasorenal hypertension (verapamil was administered at 12 and 18 h during last 2 weeks of experiment). In different seasons the definite differences in therapeutic effect of verapamil depending on the time of its administration were revealed.
Lepakhin
V K
VK
Frolov
V A
VA
Matyev
E S
ES
Kazanskaia
T A
TA
Mogilevskiĭ
V A
VA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004334:Drug Administration Schedule; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D012621:Seasons; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil
Vliianie verapamila na arterial'noe davlenie i nekotorye pokazateli sokratitel'noĭ funktsii serdtsa u krolikov s renoprivnoĭ arterial'noĭ gipertenzieĭ pri ego vvedenii vraznoe vremia sutok.