[Plasma erythropoietic activity in children with sepsis].
The low plasma erythropoietic (Epo) activity which is non-adequate to manifestation of anemia, and the lack of correlation between Epo activity and the degree of anemia and hypoxia were found in children with sepsis. The lowest Epo activity was determined in plasma of patients after repeatedly blood transfusion and in emaciated children. The non-specific Epo activity inhibitor was determined in acute period of sepsis in majority of patients. We suppose that the low Epo activity was due to the violation of Epo synthesis regulation mechanism or was connected with the presence of non-specific inhibitors. These results suggest recombinant Epo for the treatment of anemia in children with sepsis.
Soboleva
M K
MK
Manakova
T E
TE
D000747:Anemia, Hypochromic / Q000097:blood / Q000150:complications; D000818:Animals; D001424:Bacterial Infections / Q000097:blood* / Q000150:complications; D001803:Blood Transfusion; D002478:Cells, Cultured; D004921:Erythropoietin / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000150:complications; D007223:Infant; D051379:Mice; D008807:Mice, Inbred BALB C; D012016:Reference Values
D006454:Hemoglobins; D004921:Erythropoietin
Eritropoéticheskaia aktivnost' plazmy u deteĭ pri sepsise.