title: Dietary supplementation with very long-chain n-3 fatty acids in man decreases expression of the interleukin-2 receptor (CD25) on mitogen-stimulated lymphocytes from patients with inflammatory skin diseases.
abstract: T-cell activation and cytokine production play an important role in several chronic inflammatory diseases. Because n-3 fatty acids exert beneficial effects on the clinical state of some of these diseases, we examined the effect of dietary supplementation of n-3 fatty acids on T-cell proliferation, expression of CD25 (interleukin-2 receptor alpha-chain), secretion of interleukin-2, interleukin-6 and tumour necrosis factor from T-cells from patients with psoriasis and atopic dermatitis. During 4 months, 21 patients supplied 6 g of highly concentrated ethyl esters of EPA and DHA in gelatin capsules daily to their diet. In the control group 20 patients supplied 6 g per day of corn oil in gelatin capsules to their diet. Eicosapentaenoic acid (20:5, n-3) of serum phospholipids increased from 14 (min 4-max 42) to 81 (min 59-max 144) mg l-1 (P < 0.01) in patients with atopic dermatitis receiving n-3 fatty acids, and from 25 (min 7-max 66) to 74 (min 46-max 142) mg l-1 (P < 0.01) in patients with psoriasis, whereas docosahexaenoic acid (22:6, n-3) increased from 65 (min 46-max 120) to 92 (min 54-max 121) mg l-1 (P < 0.05) and from 81 (min 38-max 122) to 92 (min 63-max 169) mg l-1 (NS) in atopic and psoriatic patients, respectively. The changes in the serum phospholipid fatty acid profile in the groups receiving n-3 fatty acids, correlate to the dietary intake of corresponding fatty acids.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Section for Dietary Reasearch, University of Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Søyland
authors.forename: T
authors.initials: T
authors.lastname: Lea
authors.forename: B
authors.initials: B
authors.lastname: Sandstad
authors.forename: A
authors.initials: A
authors.lastname: Drevon
mesh_terms: D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000097:blood / Q000178:diet therapy*; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D010835:Phytohemagglutinins / Q000494:pharmacology; D011565:Psoriasis / Q000097:blood / Q000178:diet therapy*; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2