title: Styrene induced pancreatic changes in rodents.
abstract: Subchronic oral exposure to styrene in rodents (25 or 50 mg/kg/day in mice; 160 or 320 mg/kg/day in rats and guinea pigs, 5 days/week) for 4 weeks resulted in moderate congestion of pancreatic lobules, focal inflammatory reactions around islets (in mice) and altered serum insulin level while blood glucose levels remained unaffected. Increased beta cell degranulation together with characteristic neoformation of islets were predominantly seen in pancreas of guinea pigs.
authors.affiliation: Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Khanna
authors.forename: G S
authors.initials: GS
authors.lastname: Rao
authors.forename: R K
authors.initials: RK
authors.lastname: Dogra
authors.forename: L J
authors.initials: LJ
authors.lastname: Shukla
authors.forename: S N
authors.initials: SN
authors.lastname: Srivastava
authors.forename: S P
authors.initials: SP
authors.lastname: Dhruv
authors.forename: R
authors.initials: R
authors.lastname: Shanker
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D010179:Pancreas / Q000187:drug effects*; D051381:Rats; D020058:Styrene; D013343:Styrenes / Q000633:toxicity*
chemical_list: D013343:Styrenes; D020058:Styrene