[Role of hereditary factors in the formation of secondary insulin dependence in patients with type II diabetes mellitus].
A total of 389 patients with diabetes mellitus were examined. A genetic analysis has shown a most high possibility of diabetes in the sibs of patients with type II diabetes and secondary insulin dependence. The authors put forward a hypothesis that secondary insulin dependence formation in diabetics with type II condition results from interactions of two gene complexes with a recessive effect, responsible for types I and II diabetes mellitus development. They suggest a model of age-dependent epistasis with an 'insulin-dependence' gene quantitative effect.
Shtandel'
S A
SA
Artamentova
L A
LA
Tikhonova
E P
EP
D000328:Adult; D000375:Aging / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D006801:Humans
Rol' nasledstvennykh faktorov v formirovanii vtorichnoĭ insulinzavisimosti u bol'nykh sakharnym diabetom II tipa.