Decrease in myeloperoxidase during differentiation of bone marrow cells by colony-stimulating factor.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) induced the proliferation and differentiation of bone marrow cells of normal mice with a concomitant loss of myeloperoxidase activity. The decrease in the enzyme activity was due to a reduced level in the bone marrow cells. These findings indicate that myeloperoxidase is not merely a marker, but may also play a role in the differentiation of stem cells into granulocytes.
Lee
E
E
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Fujita
M
M
Miki
Y
Y
Kariya
K
K
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009195:Peroxidase / Q000378:metabolism*; D013234:Stem Cells / Q000187:drug effects
D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D009195:Peroxidase