Antineuronal antibodies in acute cerebellar ataxia following Epstein-Barr virus infection.
A 29-year-old man developed acute cerebellar ataxia following Epstein-Barr virus infection. Serum IgG and IgM antibodies reacted with both nuclear and cytoplasmic elements of neurons. Western blot revealed IgG binding to the 34- and 29-kd bands and IgM binding to the 44-, 37-, and 29-kd bands. The IgM reactivity gradually reduced. There was no identifiable neoplasm and the ataxia gradually improved. These findings suggest a role for autoimmune mechanisms in the pathogenesis of acute cerebellar ataxia.
Ito
H
H
Department of Neurology, Kitasato University East Hospital, Kitasato University, Kanagawa, Japan.
Sayama
S
S
Irie
S
S
Kanazawa
N
N
Saito
T
T
Kowa
H
H
Haga
S
S
Ikeda
K
K
D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D002524:Cerebellar Ataxia / Q000276:immunology* / Q000382:microbiology; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
D001323:Autoantibodies