Bacteriophage prevents destruction of skin grafts by Pseudomonas aeruginosa.
Infection of split skin grafts in guinea-pigs by Pseudomonas aeruginosa 3719 destroys them, and bacteriophage BS24, lytic for strain 3719, protects the grafts. This supports the view that phage could be used to prevent infection of skin grafts applied to the contaminated wounds of burned patients.
Soothill
J S
JS
Department of Infection, Medical School, Birmingham, UK.
D000818:Animals; D002056:Burns / Q000150:complications / Q000601:surgery*; D006168:Guinea Pigs; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control; D011552:Pseudomonas Infections / Q000473:pathology / Q000517:prevention & control*; D017105:Pseudomonas Phages / Q000502:physiology*; D016038:Skin Transplantation; D014946:Wound Infection / Q000473:pathology / Q000517:prevention & control*