title: Surgical timing in aortic regurgitation: left ventricular function analysis by contractility score.
abstract: In 32 patients with aortic regurgitation, angiographic evaluation of global left ventricular performance before and after aortic valve replacement was carried out by means of a computer-analyzed contractility scoring system. A strong correlation was detected between the preoperative and postoperative contractility score. Postoperatively, the score decreased in all but 3 patients, becoming normal or near normal in 21 of 27 patients whose preoperative value had been less than 40. However, all 5 patients with a preoperative contractility score of 40 or greater exhibited a persistently elevated score after operation that indicated the presence of irreversible contractile dysfunction. Patients in groups A and B (preoperative score, 0 to 40) experienced a good surgical outcome, and at 5-year follow-up were in New York Heart Association functional class I. Patients in group C (preoperative score, > 40) altogether had a very poor surgical outcome, although they did experience a short to midterm period of symptomatic relief. It is important to offer aortic valve replacement to patients with aortic regurgitation before their chances for a good functional result are lost. The computer-analyzed contractility score may be a useful index for determining the optimal timing of operation in these patients, particularly those who show features consistent with impaired left ventricular function but are asymptomatic and who should undergo aortic valve replacement before symptoms of definitive left ventricular failure develop.
authors.affiliation: Divisione di Chirurgia Toracica e Cardiovascolare, Ospedale Luigi Sacco, Milano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Di Biasi
authors.forename: A
authors.initials: A
authors.lastname: Pajé
authors.forename: M
authors.initials: M
authors.lastname: Salati
authors.forename: G
authors.initials: G
authors.lastname: Bozzi
authors.forename: M
authors.initials: M
authors.lastname: Viecca
authors.forename: A
authors.initials: A
authors.lastname: Cialfi
authors.forename: M
authors.initials: M
authors.lastname: Di Biasi
authors.forename: S
authors.initials: S
authors.lastname: Guzzetti
authors.forename: C
authors.initials: C
authors.lastname: Santoli
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D002933:Cineradiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006350:Heart Valve Prosthesis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left