Anticarcinogenic effect of tetrachlorodecaoxide after total-body gamma irradiation in rats.
Tetrachlorodecaoxygen (TCDO) therapy of acute radiation syndrome was tested for a possible influence on the development of X-ray-induced malignancies. BD IX rats were exposed to total-body irradiation (TBI, gamma rays, 9 or 11 Gy) and received daily intravenous injections of either TCDO or physiological saline solution from days 4 through 11 after TBI. The short-term TCDO therapy reduced the acute death rate markedly, but survival rates after 4 months were similar with and without TCDO. The first malignancy after TBI occurred on day 103, and over the lifetime of the animals the tumor incidence in the group given TBI (11 Gy) without TCDO treatment was 73% vs 20% in animals with short-term TCDO therapy after TBI. In particular, there was a highly significant prevention of radiation-induced leukemia [P (one-sided) < 0.001] by TCDO, and a significantly reduced incidence of malignant epithelial tumors [P (one-sided) < 0.05]. The development of sarcomas was not affected by TCDO. Long-term survival was not enhanced by TCDO due to the occurrence of bronchopneumonial infections about 1 year after TBI. In conclusion, TCDO is not only a potent therapeutic agent in acute radiation syndrome, but it also significantly reduced the carcinogenic risk in rats after exposure to ionizing radiation.
Kempf
S R
SR
Institute for Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Port
R E
RE
Ivankovic
S
S
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002713:Chlorine / Q000494:pharmacology*; D005260:Female; D005720:Gamma Rays; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000517:prevention & control*; D010087:Oxides / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D014916:Whole-Body Irradiation
D016588:Anticarcinogenic Agents; D010087:Oxides; D011837:Radiation-Protective Agents; D002713:Chlorine; C041955:tetrachlorodecaoxide