The apolipoprotein B messenger RNA editing enzyme.
The editing of apolipoprotein (apo)B messenger RNA (mRNA) involves a novel C to U modification, which creates an in-frame stop-translation codon, thereby generating the carboxyl-terminal of apoB48. The 27 kDa catalytic subunit of the editing enzyme has been cloned and established to be a zinc-containing cytidine deaminase. The catalytic subunit is guided to the editing site by a second targeting subunit or subunits. A candidate for the targeting subunit is a 60 kDa protein that can be UV crosslinked to the sequence UGAU, which is part of a motif downstream of the editing site that is essential for editing.
Scott
J
J
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Navaratnam
N
N
Bhattacharya
S
S
Morrison
J R
JR
D000595:Amino Acid Sequence; D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics*; D001483:Base Sequence; D001665:Binding Sites; D003564:Cytidine Deaminase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008969:Molecular Sequence Data; D017393:RNA Editing; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D017385:Sequence Homology
D001055:Apolipoproteins B; D012333:RNA, Messenger; D003564:Cytidine Deaminase