An unusual late reaction to Zyderm I injections: a challenge for treatment.
We describe a patient who, 2 1/2 years after injection with Zyderm I collagen, developed large erythematous indurated nodules and plaques at the facial injection sites. This occurred despite a prior negative skin test with the injectable material. Histopathologically, a sarcoid-like foreign-body reaction was present in the dermis and subcutaneous fat and muscles. Retesting with Zyderm I collagen on the forearm produced a positive reaction that showed, histologically, a sarcoid-like reaction similar to that which was found in the face. Various modes of therapy have failed to clear the facial lesions and disfigurement.
Moscona
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RR
Department of Plastic Surgery, Rambam Medical Center, Haifa, Israel.
Bergman
R
R
Friedman-Birnbaum
R
R
D000328:Adult; D001706:Biopsy; D003094:Collagen / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D008047:Lip Diseases / Q000209:etiology*; D012882:Skin Tests; D013518:Surgery, Plastic / Q000009:adverse effects*; D013997:Time Factors
D003094:Collagen