title: Unclassifiable high grade malignant T-cell lymphoma with clonal evolution.
abstract: We report a case of leukemic malignant T-cell lymphoma with mixed small and large cells. The small cells displayed a mature CD8-positive phenotype, a diploid DNA distribution by cell cycle analysis, and structural karyotypic abnormalities. Large cells were near triploid, showed additional structural cytogenetic abnormalities and a more immature membrane phenotype without CD8 expression. Altogether, these data provide suggestive evidence for a clonal evolution from a mature small cell T-cell lymphoma to a more immature large cell proliferation.
authors.affiliation: Département d'Hématologie et Oncologie Médicale, Centre Hospitalier Universitaire, Poitiers, France.
authors.forename: A
authors.initials: A
authors.lastname: Brizard
authors.forename: F
authors.initials: F
authors.lastname: Brizard
authors.forename: P
authors.initials: P
authors.lastname: Babin
authors.forename: G
authors.initials: G
authors.lastname: Agius
authors.forename: V
authors.initials: V
authors.lastname: Delwail
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
authors.forename: J
authors.initials: J
authors.lastname: Tanzer
mesh_terms: D000368:Aged; D016827:CD8 Antigens / Q000032:analysis; D002453:Cell Cycle; D002999:Clone Cells / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000235:genetics / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000145:classification / Q000235:genetics / Q000473:pathology*; D011003:Ploidies
chemical_list: D016827:CD8 Antigens; D004273:DNA, Neoplasm