title: A case of chronic epileptic encephalopathy of neonatal onset. A probable concern of human cytomegalovirus.
abstract: A 10-year-old male patient, who had suffered from intractable convulsions from the neonatal period, is presented. Serial brain images suggested slow, gradual destruction of neural elements. Human cytomegalovirus (HCMV) DNA was detected in his cerebrospinal fluid (CSF) by means of the polymerase chain reaction. Intrathecal interferon had a favorable effect on his seizures. We assume a close relationship between HCMV and some chronic types of epileptic encephalitis/encephalopathy.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kohyama
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kajiwara
authors.forename: M
authors.initials: M
authors.lastname: Shimohira
authors.forename: Y
authors.initials: Y
authors.lastname: Iwakawa
mesh_terms: D003587:Cytomegalovirus / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D004279:DNA, Viral / Q000032:analysis; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D017403:In Situ Hybridization; D007231:Infant, Newborn; D007278:Injections, Spinal; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins
chemical_list: D004279:DNA, Viral; D007370:Interferon Type I; D011994:Recombinant Proteins