[Characteristics of T-suppressors responsible for the competition between cellular and humoral immune response in the spleen].
After intraperitoneal immunization by different sheep erythrocytes doses (1 x 10(6) - 1 x 10(8)) in the spleen of CBA strain and (CBA x C57Bl/6)F1 hybrid mice short-living suppressor cells, which are able to inhibit mature IgM-but not IgG-plaque-forming cells have been revealed. The suppression degree is in direct dependency on the delayed type hypersensitivity effectors activity. The revealed suppressor splenocytes are Thy-1-positive, do not adhere to plastic, are antigen-specific, require the H-2 complex restriction, are unable to homing into regional lymph nodes, their induction is abolished by administration of 200 mg/kg, but not 20 mg/kg of cyclophosphamide. It has been shown that T-suppressors of delayed type hypersensitivity are able to carry out the function of contrasuppressors.
Gusev
E Iu
EIu
Kevorkov
N N
NN
D000818:Animals; D000917:Antibody Formation; D003520:Cyclophosphamide / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D003520:Cyclophosphamide
Kharakteristika T-supressorov, otvetstvennykh za konkurentsiiu mezhdu kletochnym i gumoral'nym immunnym otvetom v selezenke.