title: [Determination of autoantibodies to pancreatic beta-cells, non-islet endocrine cells and fibroblasts in patients with newly detected diabetes mellitus].
abstract: The clinical onset of insulin-dependent diabetes (IDD) is characterized by the onset of circulation of autoantibodies to beta-cells. Thirty-three newly detected IDD patients and 14 newly detected patients with noninsulin-dependent diabetes mellitus were examined for autoantibodies to antigen P 64-69, to surface antigen of islet cells, to thyrocyte microsomal fraction, thyroglobulin, hypophysis, fibroblasts; the levels of circulating immune complexes were measured as well. IDD debut was found associated with the appearance of antibodies to pancreatic islet cells, thyroid, thyroglobulin, hypophysis, fibroblasts, this indicating a polyclonal activation of the immunity system. A relationship was revealed between antifibroblast antibody and anti-islet-cell antibody. Antihypophyseal antibodies were detected in 43% of patients with noninsulin dependent diabetes. Nine per cent of IDD patients and 24% of patients with noninsulin dependent condition were negative in the tests.
authors.forename: O M
authors.initials: OM
authors.lastname: Smirnova
authors.forename: L A
authors.initials: LA
authors.lastname: Chugunova
authors.forename: E N
authors.initials: EN
authors.lastname: Zlobina
authors.forename: S V
authors.initials: SV
authors.lastname: Brykova
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Keda
authors.forename: I V
authors.initials: IV
authors.lastname: Kriukova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Pankov
authors.forename: V I
authors.initials: VI
authors.lastname: Kandror
authors.forename: M I
authors.initials: MI
authors.lastname: Arbuzova
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013997:Time Factors
chemical_list: D001323:Autoantibodies
vernacular_title: Opredelenie autoantitel k beta-kletkam podzheludochnoĭ zhelezy, neostrovkovym éndokrinnym kletkam i fibroblastam u bol'nykh s vpervye vyiavlennym sakharnym diabetom.