[Antiarrhythmic effect of estradiol-dipropionate in animals of different sexes].
Repetitive injections of estradiol, performed for many days, caused a diminution of resting potential of ventricular cardiomyocytes; spontaneously reversible ventricular fibrillation aroused 2 times more often, and the latent period of development of aconitine-induced ventricular fibrillation increased for 3 times in males, and for 5 times--in females. The antiarrhythmic effect of estradiol may be caused by its action on potassium current.
Korbin
V I
VI
Ignatova
E D
ED
Baliakin
Iu V
IuV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002645:Chickens; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000473:pathology; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000473:pathology
D000889:Anti-Arrhythmia Agents; D004958:Estradiol; C023482:estradiol dipropionate
Antiaritmicheskiĭ éffekt éstradiola-dipropionata u zhivotnykh raznogo pola.