title: Frequency dependence of pulmonary and chest wall mechanics in young and adult cats.
abstract: The frequency (f) dependence of pulmonary and chest wall mechanics was assessed in nine kittens and four cats. Kittens and cats were anesthetized, paralyzed, and mechanically ventilated at various f between 0.13 and 1.6 Hz and 0.09 and 0.79 Hz, respectively. Resistance and dynamic compliance pertaining to the respiratory system (Rrs and Cdyn,rs), lungs (RL and Cdyn,L), and chest wall (RW and Cdyn,W) were estimated by fitting a single-compartment model to data obtained from regular ventilation. Static lung and chest wall compliances (Cst,L and Cst,W) were computed from quasi-static pressure-volume data. Lung tissue resistance (Rti) was estimated with alveolar capsules in open-chest animals. The f dependence of the two-compartment viscoelastic model of the respiratory system was assessed by computing the effective resistance [Rmod,rs(omega)] and compliance [Cmod,rs(omega)] from data obtained at the lowest experimental f. Both Cdyn,L and Cdyn,W decreased with increasing f in all animals. Cdyn,L/Cst,L and Cdyn,W/Cst,W were lower in kittens than in cats. RL and RW decreased markedly with f in all animals. Rti/RL showed a marked f dependence, its values being similar in both young and adult cats at their respective resting f. CstW/Cst,L ratio was higher in kittens than in cats. A better agreement was found between Cmod,rs(omega) and Cdyn,rs than between Rmod,rs(omega) and Rrs.
authors.affiliation: Meakins-Christie Laboratories, McGill University Clinic, Montreal, Quebec, Canada.
authors.forename: F R
authors.initials: FR
authors.lastname: Shardonofsky
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: D H
authors.initials: DH
authors.lastname: Eidelman
mesh_terms: D000375:Aging / Q000502:physiology*; D000399:Air Pressure; D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D002415:Cats; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D008954:Models, Biological; D010991:Plethysmography; D011650:Pulmonary Alveoli / Q000502:physiology; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000502:physiology*; D013909:Thorax / Q000502:physiology*