title: Spontaneous Clostridium septicum myonecrosis in congenital neutropaenia.
abstract: Spontaneous Clostridium septicum myonecrosis is an uncommon disorder that has been described in association with malignancy, immunosuppression and neutropaenia. Typical clostridial myonecrosis develops without a visible portal of entry and mortality is high. The pathogenesis is not completely understood but the clostridia may gain access to the circulation via areas of ileo-caecal ulceration secondary to enterocolitis, antibiotics or neoplasms. A 5 year old boy with congenital neutropaenia presented with spontaneous Clostridium septicum myonecrosis in the thigh. Limb salvage was achieved using antibiotics, hyberbaric oxygenation and selective debridement. The portal of entry may have been the gastrointestinal tract as colonic ulceration may occur in neutropaenia, and pre-morbid clindamycin administration may have encouraged overgrowth of colonic clostridia.
authors.affiliation: Department of Surgery, Prince of Wales Children's Hospital, Randwick, New South Wales, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Keogh
authors.forename: I
authors.initials: I
authors.lastname: Unsworth
authors.forename: M
authors.initials: M
authors.lastname: Vowels
authors.forename: I B
authors.initials: IB
authors.lastname: Kern
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003646:Debridement; D004487:Edema / Q000382:microbiology / Q000473:pathology; D005738:Gas Gangrene / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D009503:Neutropenia / Q000151:congenital*; D013848:Thigh / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents