Effect of dietary magnesium deficiency with/without cholesterol supplementation on phospholipid content in liver, plasma and erythrocytes of rabbits.
The effect of magnesium deficiency with/without supplementary cholesterol on phospholipid content in liver, plasma and erythrocytes was investigated in New Zealand White male rabbits. After the rabbits had been fed a low magnesium and/or high cholesterol diet for seven weeks, the phospholipid content in liver, plasma and erythrocytes was measured. Dietary magnesium deficiency produced a marked elevation of total phospholipid and certain individual phospholipids in the rabbit liver. The elevation was accentuated by cholesterol supplementation. In the plasma, a low magnesium intake enhanced plasma phosphatidylcholine, phosphatidic acid, phosphatidylinositol, and sphingomyelin, but an activated conversion from phosphatidylethanolamine to phosphatidylcholine made the increase in phospholipid insignificant. On the other hand, a low magnesium intake restricted the increase in magnitude of phospholipid caused by cholesterol supplementation. In the erythrocytes, total phospholipid, phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine were decreased by a low magnesium and/or a high cholesterol intake. We suggest that the increased contents of total phospholipid and/or certain individual phospholipids in the livers and plasma resulted from the enhanced synthesis of phospholipid in the liver by low magnesium intake. A decreased utilization of food by low magnesium diet limited the magnitude of plasma phospholipid increase produced by cholesterol supplementation.
Zhou
Q
Q
Burnsides Research Laboratory, University of Illinois, Urbana.
Mahfouz
M M
MM
Kummerow
F A
FA
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004032:Diet; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006128:Growth / Q000502:physiology; D008099:Liver / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol