title: [Effects of vasoactive cyclooxygenase products on shunt flow and extravascular lung water in acute lung injuries].
abstract: Using 50 mongrel dogs with alveolar flooding produced by oleic acid administration, the possible roles of vasoactive cyclooxygenase products on intrapulmonary shunt flow (QS/QT) and extravascular lung water (ETVI) in acutely injured lungs were assessed. Suppressing cyclooxygenase activity with indomethacin administration diminished the concentrations of thromboxane (TX) B2 and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in arterial blood, resulting in a significant reduction in QS/QT. Furthermore, indomethacin completely suppressed the increase in ETVI. Inhibition of TXA2 generation by OKY-046 (thromboxane A2 synthase blocker) diminished the concentration of TXB2 while increasing that of 6-keto-PGF1 alpha in blood. Administration of either OKY-046 or synthetic prostacyclin (PGI2) markedly enhanced QS/QT, in association with an increase in ETVI. In conclusion, the potent vasodilator prostacyclin was considered to enhance shunt flow, leading to the augmentation of edema formation.
authors.affiliation: Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Takasugi
authors.forename: Y
authors.initials: Y
authors.lastname: Oyamada
authors.forename: A
authors.initials: A
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000208:Acute Disease; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology; D015633:Extravascular Lung Water / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism*; D008689:Methacrylates / Q000494:pharmacology; D009829:Oleic Acids; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism / Q000502:physiology*; D011652:Pulmonary Circulation
chemical_list: D001095:Arachidonic Acids; D008689:Methacrylates; D009829:Oleic Acids; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases; C034364:ozagrel; D007213:Indomethacin