Vascular alterations in rats with high blood pressure induced by social deprivation stress.
While an activation of the opioid system has been found to play a role only in the triggering of the high blood pressure induced by brief (7-14 days) social deprivation stress in Wistar rats, factors responsible for the maintenance of the hypertension after long-term (30-35 days) isolation remained to be elucidated. To this aim, the effects of social deprivation stress on the functional and morphological features of blood vessels were studied. The tail artery, as a muscular vessel, and the aorta, as a large elastic vessel were used in these experiments. In ex vivo experiments, aorta and tail artery strips from rats isolated for 30-35 days were found to be hyperreactive to noradrenaline.
Parra
L
L
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Fuentes
J A
JA
Alsasua
A
A
D000818:Animals; D001013:Aorta, Thoracic / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D001158:Arteries / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011610:Psychosocial Deprivation; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D013623:Tail / Q000098:blood supply*
D009638:Norepinephrine