title: Toxic epidermal necrolysis with tracheobronchial and pulmonary complications.
abstract: A 55-year-old man developed multiple erythematous skin lesions after surgery for acoustic neurinoma. Necrosis and detachment of the epidermis developed and a diagnosis of toxic epidermal necrolysis (TEN) was made. Progressive dyspnea was evident two days after the onset of the skin lesions. Chest X-ray revealed diffuse interstitial shadows in both lung fields. On bronchoscopic examination, erosion, vesicle formation, necrosis and desquamation of the epidermis were seen in the tracheobronchial mucosa. Therapy, including prednisolone, improved the skin lesions as well as the chest X-ray and bronchoscopic findings. Tracheobronchial and pulmonary lesions were followed before, during and after treatment of TEN.
authors.affiliation: Department of Medicine, School of Medicine, Keio University, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Kamata
authors.forename: F
authors.initials: F
authors.lastname: Sakamaki
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Urano
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Kanazawa
authors.forename: M
authors.initials: M
authors.lastname: Kai
authors.forename: T
authors.initials: T
authors.lastname: Izumi
authors.forename: W
authors.initials: W
authors.lastname: Naka
mesh_terms: D001980:Bronchi / Q000473:pathology; D001982:Bronchial Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D001999:Bronchoscopy; D004359:Drug Therapy, Combination; D004817:Epidermis / Q000473:pathology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011859:Radiography; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014132:Trachea / Q000473:pathology; D014133:Tracheal Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology