title: Influence of Tołpa Peat Preparation on haemostasis in rats.
abstract: The influence of Tołpa Peat Preparation (TPP) on certain parameters of haemostasis was studied. The present results indicate that TPP (100, 200 and 300 mg/kg p.o.) had no influence on the bleeding time, clotting time, thrombin time, prothrombin time, kaolin-kephalin time, euglobulin lysis time, the concentration of fibrinogen, the platelet count and ADP-induced platelet aggregation. No changes in animals after long-term treatment with TPP (100 mg/kg for two weeks) were found either. In in vitro studies TPP given in concentrations 10(-5), 10(-4), 10(-3) and 10(-2) g/cm3 was used and certain changes of the studied parameters, probably caused by the presence of high salt content in this substance, were observed.
authors.affiliation: Department of Pharmacodynamics, School of Medicine, Białystok, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Buczko
authors.forename: B
authors.initials: B
authors.lastname: Malinowska
authors.forename: M H
authors.initials: MH
authors.lastname: Pietraszek
authors.forename: D
authors.initials: D
authors.lastname: Pawlak
authors.forename: E
authors.initials: E
authors.lastname: Chabielska
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001760:Bleeding Time; D002241:Carbohydrates / Q000494:pharmacology*; D004338:Drug Combinations; D006487:Hemostasis / Q000187:drug effects*; D006812:Humic Substances / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D012987:Soil; D013918:Thrombin Time; D014574:Uronic Acids / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; D012987:Soil; C084029:Tolpa; D014574:Uronic Acids