title: Esperamicin P, the tetrasulfide analog of esperamicin A1.
abstract: A minor congener of esperamicin A1 [1], designated esperamicin P (BMY-41339, 2), was isolated from a fermentation broth of Actinomadura verrucosospora and determined to differ from esperamicin A1 by having a methyl tetrasulfide moiety instead of a methyl trisulfide. It was active against xenografted tumors in mice and exhibited antimicrobial activity. Interconversions of 2 and 1 have been observed for DMSO solutions of both congeners at room temperature.
authors.affiliation: PRI/DynCorp., NCI-Frederick Cancer Research & Development Center, MD 21702-1201.
authors.forename: J A
authors.initials: JA
authors.lastname: Beutler
authors.forename: P
authors.initials: P
authors.lastname: Clark
authors.forename: A B
authors.initials: AB
authors.lastname: Alvarado
authors.forename: J
authors.initials: J
authors.lastname: Golik
mesh_terms: D000191:Actinomycetaceae / Q000378:metabolism*; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004121:Dimethyl Sulfoxide; D004354:Drug Screening Assays, Antitumor; D053281:Enediynes; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010084:Oxidation-Reduction; D014407:Tumor Cells, Cultured
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D053281:Enediynes; C088925:esperamicin P; C047543:esperamicin A1; D004121:Dimethyl Sulfoxide