Leishmanial glycosomes contain superoxide dismutase.
In this work we report that superoxide dismutase is entrapped in a microbody-like organelle, the glycosome, present in Leishmania spp. Studies on the sensitivity of the enzyme to various inhibitors indicated that glycosomal superoxide dismutase is predominantly of the Cu/Zu type. Localization of superoxide dismutase in glycosomes points to the major importance of this organelle in the survival of this pathogen, suggesting a new approach towards chemotherapy for leishmaniasis.
Dey
R
R
Indian Institute of Chemical Biology, Calcutta.
Datta
S C
SC
D000818:Animals; D002458:Cell Fractionation; D005189:False Positive Reactions; D007893:Leishmania donovani / Q000201:enzymology* / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D015388:Organelles / Q000201:enzymology*; D012966:Sodium Cyanide / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D013482:Superoxide Dismutase; D012966:Sodium Cyanide