Platelet serotonin measures in primary dysthymia.
Serotonergic function in 22 patients with primary dysthymia and 22 normal volunteers was evaluated by measuring [3H]serotonin uptake and [3H]paroxetine binding in platelets. A significantly lower maximum rate of serotonin uptake was noted in the dysthymic patients than in the normal subjects, indicating a possible serotonergic dysfunction in dysthymia. However, the values for parameters of paroxetine binding were similar in the two groups.
Ravindran
A V
AV
Department of Psychiatry, University of Ottawa, Ont., Canada.
Chudzik
J
J
Bialik
R J
RJ
Lapierre
Y D
YD
Hrdina
P D
PD
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D017374:Paroxetine / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000097:blood* / Q000502:physiology
D011985:Receptors, Serotonin; D012701:Serotonin; D017374:Paroxetine