title: Changes in cerebrospinal fluid biotinidase activity in Staphylococcus aureus meningitis.
abstract: An early increase in activity of biotinidase in the cerebrospinal fluid (CSF) during the course of acute Staphylococcus aureus meningitis in a subject with subacute sclerosing panencephalitis (SSPE) is reported. A possible role of CSF biotinidase in the hydrolysis of specific opioid neuropeptides during acute inflammatory processes involving the CSF-central nervous system compartment is suggested.
authors.affiliation: Endocrine and Metabolism Research Laboratory, National Children's Medical Research Center, National Children's Hospital, Tokyo, Japan.
authors.forename: C
authors.initials: C
authors.lastname: De Felice
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Nihei
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: I
authors.initials: I
authors.lastname: Hibi
mesh_terms: D000581:Amidohydrolases / Q000134:cerebrospinal fluid*; D043523:Biotinidase; D002648:Child; D005260:Female; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000150:complications / Q000201:enzymology; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000134:cerebrospinal fluid; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid* / Q000150:complications / Q000201:enzymology; D013344:Subacute Sclerosing Panencephalitis / Q000150:complications
chemical_list: D012794:Sialic Acids; D000581:Amidohydrolases; D043523:Biotinidase; D019158:N-Acetylneuraminic Acid