Usefulness of exercise testing shortly after acute myocardial infarction for predicting 10-year mortality.
Previous studies on the prognostic value of exercise test variables after acute myocardial infarction (AMI) are limited methodologically and have yielded inconsistent results. This study determined whether 6 exercise test variables (systolic blood pressure, ST-segment depression or elevation, exercise capacity, arrhythmias, and angina pectoris) after controlling for age and sex, enhance 6 clinical variables (digoxin, previous AMI, history of systemic hypertension and angina, Killip class, and stress) as predictors of cardiovascular death and act as independent predictors as well. The present study followed 258 patients for 10.6 years, each of whom had AMI between 1977 and 1980 and an exercise test before hospital discharge. By 1988, 71 of the 258 patients had died, 56 of cardiovascular causes. This study is unique because exposure and outcome variables are clearly defined and follow-up was complete and longer than in previous studies. Multivariate survival analysis using an exponential model was tested to evaluate the conditional effects of the exercise test and clinical variables and to control for confounders. The model combined the exercise test and clinical variables. Results are reported with hazard ratios (HR) and 95% confidence intervals (CI). For important clinical risk predictors, the HRs with CIs are: digoxin use, HR 4.0 (CI 1.8, 8.5); history of prior AMI, HR 2.4 (CI 1.2, 4.7); history of systemic hypertension, HR 2.5 (CI 1.3, 4.5); angina, HR 2.4 (CI 1.3, 4.5); and stress, HR 4.2 (CI 2.2, 7.9).(ABSTRACT TRUNCATED AT 250 WORDS)
Froelicher
E S
ES
University of California, San Francisco 94143-0610.
D004562:Electrocardiography; D005080:Exercise Test / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors