[The value of urine phosphohexose isomerase activity in comparison with urine cytology. First diagnosis and tumor after-care in patients with cancer of the urinary bladder].
The importance of phosphohexose (PHI) activity in the urine of patients with carcinoma of the urinary bladder is examined on the basis of enzyme-histochemical studies in tumor cell homogenizates after transurethral resection for transitional cell carcinoma. The results gave rise to the question of whether the enzyme-histochemical activity patterns were reflected in the urine in the form of photometrically measurable activity, and thus whether the PHI activity can be used in screening as a marker to complement the standard urine cytological procedure. The sensitivity of PHI measurement was determined at 89%. The measurement of PHI in the urine of patients with an ileum neobladder or of patients with urinary tract infections does not provide any useful information.
Voigt
W
W
Urologische Klinik, Justus-Liebig-Universität Giessen.
Rothauge
C F
CF
Schäffer
R
R
D000328:Adult; D000359:Aftercare; D000368:Aged; D014408:Biomarkers, Tumor / Q000652:urine*; D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005956:Glucose-6-Phosphate Isomerase / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D012016:Reference Values; D015203:Reproducibility of Results; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014556:Urine / Q000166:cytology*
D014408:Biomarkers, Tumor; D005956:Glucose-6-Phosphate Isomerase
Die Wertigkeit der Phosphohexoseisomerase-(PHI-)Aktivitätsbestimmung im Urin im Vergleich mit der Urinzytologie. Erstdiagnose und Tumornachsorge bei Patienten mit Harnblasenkarzinom.