title: Naphtyl methyl imidazoline (NMI) membranes interactions: NMR study and evaluation of possible radioprotective consequences.
abstract: The interactions of the radioprotective molecule Naphtyl methyl imidazoline (NMI) with membranes have been studied using biophysical and biochemical methods. 1H, 2H and 31P-NMR methods showed a strong interaction with the deep part of the layer of model membranes inducing the formation of a new membrane compartment. These properties are not involved in the radioprotection effect of NMI which is more probably due to its vasoconstrictive properties.
authors.affiliation: CRSSA 24, La Tronche, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Debouzy
authors.forename: Y
authors.initials: Y
authors.lastname: Chancerelle
authors.forename: F
authors.initials: F
authors.lastname: Fauvelle
authors.forename: H
authors.initials: H
authors.lastname: Vezin
authors.forename: C
authors.initials: C
authors.lastname: Marroncles
authors.forename: C
authors.initials: C
authors.lastname: Cruz
authors.forename: J M
authors.initials: JM
authors.lastname: Maillet
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D008566:Membranes / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D008567:Membranes, Artificial; D009278:Naphazoline / Q000737:chemistry*; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D008567:Membranes, Artificial; D011837:Radiation-Protective Agents; D009278:Naphazoline