Endometrial cancer in four sisters: report of a kindred with presumed cancer family syndrome.
Hereditary nonpolyposis colorectal cancer (HNPCC, synonyms: cancer family syndrome, Lynch syndrome) is characterized by the occurrence of colorectal cancer and other primary tumors in susceptible family members. Inheritance is autosomal dominant with high penetrance. Endometrial cancer is the most frequent extracolonic malignancy in gene carriers. The criteria for the diagnosis HNPCC include the occurrence of colorectal cancer in three close relatives. However, not only colorectal cancer but also endometrial cancer may indicate HNPCC. We present a family diagnosed as a probable HNPCC kindred after endometrial cancer was observed in four sisters. One of these patients and the father of the four sisters had had colorectal cancer. This kindred illustrates the importance of recording the family history in patients with endometrial cancer.
Menko
F H
FH
Department of Clinical Genetics, Free University Hospital, Amsterdam, The Netherlands.
Verheijen
R H
RH
Everhardt
E
E
Louwé
L A
LA
Wijnen
J T
JT
Band
S C
SC
Felt-Bersma
R J
RJ
Vasen
H F
HF
Khan
P M
PM
D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D005192:Family Health; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D010375:Pedigree
D004273:DNA, Neoplasm