Red cell magnesium and glutathione peroxidase in infertile women--effects of oral supplementation with magnesium and selenium.
Six women with a history of unexplained infertility or early miscarriage and who had failed to normalize their red cell magnesium (RBC-Mg) levels after four months of oral magnesium supplementation (600 mg/day) were investigated for red cell glutathione peroxidase activity (RBC-GSH-Px) and were compared with six age-matched women with a history of unexplained infertility or miscarriage who did normalize their RBC-Mg levels on magnesium supplementation. The six non-normalizers had significantly lower (P < 0.0001) RBC-GSH-Px levels than the six normalizers. After a further two months of 200 micrograms daily oral selenium as selenomethionine and oral magnesium supplements, all six women normalized their RBC-Mg (P < 0.0001) and RBC-GSH-Px (P < 0.0001) levels. All 12 previously infertile women have produced normal healthy babies all conceiving within eight months of normalizing their RBC-Mg levels. The possible relevance of these findings to the medical treatment of infertility is discussed.
Howard
J M
JM
Biolab Medical Unit, London, UK.
Davies
S
S
Hunnisett
A
A
D000022:Abortion, Spontaneous; D000284:Administration, Oral; D000328:Adult; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D011247:Pregnancy; D012016:Reference Values; D012643:Selenium / Q000008:administration & dosage / Q000627:therapeutic use*
D005979:Glutathione Peroxidase; D012643:Selenium; D008274:Magnesium