A technique for quantitative measurement of clonic convulsions in rats.
A capacitance sensor which detects vibrations caused by the movements of animals can be used for measuring automatically the clonic convulsions induced by chemical convulsants. This knowledge has been utilized to devise an instrument which has satisfactorily measured the clonic convulsions induced by picrotoxin in rats.
Paul
V
V
Department of Pharmacology & Environmental Toxicology, Dr. A.L.M. Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani.
Kazi
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation; D010852:Picrotoxin / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D010852:Picrotoxin