title: Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase.
abstract: Ninety-four consecutive patients with chronic myelogenous leukemia in first clinical chronic phase, median age of 34.0 years (range, 6.8 to 52.4 years), with a histocompatible sibling donor, were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation (BMT). The median time from diagnosis to BMT was 7.0 months (range, 2.3 to 72.0 months). Sixty patients were treated before BMT with hydroxyurea alone, four patients with busulfan alone, one patient with interferon alone, and the other 29 patients were treated with various combinations of these drugs. Cumulative probabilities of overall survival, event-free survival, and relapse at 5 years were 73%, 64%, and 14%, respectively. The median follow-up time for surviving patients was 38 months, ranging from 12 to 88 months. By stepwise Cox regression analysis, significant prognostic variables were age at transplant, acute graft-versus-host disease > or = grade II, cytomegalovirus-associated interstitial pneumonitis, and years from diagnosis to BMT.
authors.affiliation: Department of Hematology/Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010.
authors.forename: D S
authors.initials: DS
authors.lastname: Snyder
authors.forename: R S
authors.initials: RS
authors.lastname: Negrin
authors.forename: M R
authors.initials: MR
authors.lastname: O'Donnell
authors.forename: N J
authors.initials: NJ
authors.lastname: Chao
authors.forename: M D
authors.initials: MD
authors.lastname: Amylon
authors.forename: G D
authors.initials: GD
authors.lastname: Long
authors.forename: A P
authors.initials: AP
authors.lastname: Nademanee
authors.forename: A S
authors.initials: AS
authors.lastname: Stein
authors.forename: P M
authors.initials: PM
authors.lastname: Parker
authors.forename: E P
authors.initials: EP
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology* / Q000401:mortality; D002423:Cause of Death; D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D016572:Cyclosporine / Q000627:therapeutic use; D003582:Cytogenetics; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000627:therapeutic use*; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D012008:Recurrence; D015996:Survival Rate; D014916:Whole-Body Irradiation
chemical_list: D005047:Etoposide; D016572:Cyclosporine; D008775:Methylprednisolone; D008727:Methotrexate