title: Local effects induced by venoms from five species of genus Micrurus sp. (coral snakes).
abstract: Venoms from five species of Micrurus (coral snakes) from Brazil (Amazonas State) were tested for the following effects: edematogenic, myotoxic, coagulant, hemorrhagic and phospholipase A2 (PLA2) detection. None of the venoms tested presented coagulant activity. The presence of PLA2 was detected by ELISA in the venoms of M. spixii, M. averyi and M. lemniscatus. The myotoxicity was estimated by the increase in the serum creatine kinase level and by histological analysis. All venoms, except that from M. surinamensis, induced intense edematogenic and myotoxic effects. The venom of M. averyi showed hemorrhagic activity which was confirmed by histopathological analysis. This is the first evidence of such an effect by coral snake venom.
authors.affiliation: Convênio Conselho Nacional de Pesquisa, Universidade do Amazonas, Manaus, Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Barros
authors.forename: D P
authors.initials: DP
authors.lastname: Fernandes
authors.forename: L C
authors.initials: LC
authors.lastname: Ferreira
authors.forename: M C
authors.initials: MC
authors.lastname: Dos Santos
mesh_terms: D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004487:Edema / Q000139:chemically induced; D004546:Elapid Venoms / Q000032:analysis / Q000633:toxicity*; D017815:Elapidae; D004797:Enzyme-Linked Immunosorbent Assay; D006470:Hemorrhage / Q000139:chemically induced; D007273:Injections, Intramuscular; D051379:Mice; D009132:Muscles / Q000187:drug effects* / Q000473:pathology*; D010741:Phospholipases A / Q000032:analysis; D054467:Phospholipases A2; D013045:Species Specificity
chemical_list: D004546:Elapid Venoms; D003402:Creatine Kinase; D010741:Phospholipases A; D054467:Phospholipases A2