title: [The determination of the optimal inoculation dose of an oral cholera bivalent chemical vaccine in a controlled trial of the vaccination of children and adolescents].
abstract: The reactogenicity and immunological effectiveness of different doses of cholera vaccine for oral administration (in tablets), containing choleragen toxoid, Ogawa and Inaba O-antigens and some of Vibrio cholerae exoenzymes, have been tested on 143 children aged 2-17 years. In this investigation the optimum immunization doses of the preparation have been established: two tablets containing 100,000 binding units (BU) of the toxoid and 2,500 units of O-antigen for children 11-14 years; four tablets containing 200,000 BU of the toxoid and 5,000 units of O-antigen for adolescents aged 15-17 years. An essential advantage of the oral vaccine over vaccines intended for parenteral administration lies in its capacity for inducing the accumulation of secretory antibodies (coproantibodies) in practically all vaccinees.
authors.forename: A A
authors.initials: AA
authors.lastname: Sumarokov
authors.forename: M N
authors.initials: MN
authors.lastname: Dzhaparidze
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Eliseev
authors.forename: G P
authors.initials: GP
authors.lastname: Nikitina
authors.forename: K A
authors.initials: KA
authors.lastname: Poliakov
authors.forename: E S
authors.initials: ES
authors.lastname: Kazakova
authors.forename: M V
authors.initials: MV
authors.lastname: Meleshchenko
authors.forename: N M
authors.initials: NM
authors.lastname: Tsareva
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Reznikov
authors.forename: G V
authors.initials: GV
authors.lastname: Adamova
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D022121:Cholera Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005243:Feces / Q000737:chemistry; D006801:Humans; D012449:Safety; D013607:Tablets; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014734:Vibrio cholerae / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D013607:Tablets; D014614:Vaccines, Synthetic
vernacular_title: Opredelenie otpimal'noĭ privivochnoĭ dozy oral'noĭ kholernoĭ bivalentnoĭ khimicheskoĭ vaktsiny v kontroliruemom opyte vaktsinatsii deteĭ i podrostkov.