[Antihypoxic effects of various derivatives of 3-hydroxypyridine on isolated rat myocardium].
Antihypoxic effect of a succinate-containing derivative of hydroxypyridine = --mexidol and its analog--emoxipin on contractile function and energy exchange of rats' myocard was investigated. It was shown reliably that mexidole have more expressed protective properties in myocardium of low-resistant (but not high-resistant) rats. In case of antihypoxant emoxipin prohypoxic properties prevail. It have been proposed that antihypoxic activity of mexidol was linked with presence of succinate in composition of the substance, which can be oxidated in this conditions.
Luk'ianova
L D
LD
Atabaeva
R E
RE
Shepeleva
S Iu
SIu
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000517:prevention & control*; D007113:Immunity, Innate; D066298:In Vitro Techniques; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D010847:Picolines / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D010847:Picolines; D010725:Phosphocreatine; C070020:emoxypine succinate; D000255:Adenosine Triphosphate; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Antigipoksicheskie éffekty nekotorykh proizvodnykh 3-oksipiridina na izolirovannyĭ miokard krys.