[Glucocorticoids specifically regulate the expression of dispersed repeating sequences in liver cells. Detection of small ID-like antisense RNA].
Differential regulation of the expression of various families of the rat genome interspersed repetitive sequences by glucocorticoid hormones in liver has been demonstrated. Small ID-like RNA complementarily associated with high-molecular-weight cytoplasmic poly(A)-containing RNAs has been identified. The results obtained indicate that glucocorticoids hormones induce expression of the B2, ID, and L1 families in rat liver. The content of the transcripts of these repetitive elements is increased by the hormones in the molecules of heterogeneous nuclear RNA. In the molecules of high-molecular-mass poly(A)-containing cytoplasmic RNA glucocorticoids increase the content of the ID-homologous sequences. In the population of the small specific RNA the content of the ID-homologous transcripts is also increased. A suggestion is put forward about the involvement of the ID-like element in the hormonal posttranscriptional regulation of gene expression at the mRNA level.
Konstantinova
I M
IM
Kulichkova
V A
VA
Petukhova
O A
OA
Pozdniakov
S G
SG
Lubchenkov
M A
MA
D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012323:RNA Processing, Post-Transcriptional; D016372:RNA, Antisense / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012091:Repetitive Sequences, Nucleic Acid
D005938:Glucocorticoids; D016372:RNA, Antisense
Gliukokortikoidy spetsificheski reguliruiut ékspressiiu dispergirovannykh povtoriaiushchikhsia posledovatel'nosteĭ v kletkakh pecheni. Vyiavlenie maloĭ ID-podobnoĭ antismyslovoĭ RNK.