[Crohn disease caused by antibiotics? A medical hypothesis based on epidemiologic data].
The increasing incidence of Crohn's disease over the last 50 years has paralleled the growing use of antibiotics in human and veterinary medicine. Administered at inadequate doses, antibiotics can induce in bacteria a capability for producing toxins. Statistical considerations also indicate that prior antibiotic treatment promotes the development of Crohn's disease. It seems logical to assume that, in persons with a relevant genetic predisposition, this disease is caused by intestinal bacteria, the biological (not morphological) properties of which have been modified by antibiotics.
Demling
L
L
Medizinischen Klinik, Universität Erlangen-Nürnberg, Schlüsselfeld.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001419:Bacteria / Q000187:drug effects; D001427:Bacterial Toxins / Q000378:metabolism; D015984:Causality; D003424:Crohn Disease / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015994:Incidence; D007422:Intestines / Q000382:microbiology; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins
Morbus Crohn durch Antibiotika? Eine medizinische Hypothese auf dem Boden epidemiologischer Daten.