Influence of flunarizine on hippocampal epileptic afterdischarges in the rat.
Epileptic afterdischarges elicited by electrical stimulation of the dorsal hippocampus in freely moving rats were not significantly changed by flunarizine administration in comparison with control sessions in which the animals received the solvent only. On the other hand, flunarizine significantly reduced the number of wet dog shakes, the main automatisms accompanying limbic afterdischarges.
Pohl
M
M
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Mares
P
P
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000503:physiopathology*; D005444:Flunarizine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D005444:Flunarizine