[Protective effect of adenosine in total brain ischemia].
Adenosine has prominent cerebro-protective effect at total brain ischemia. Other nucleotides and nucleosides are less active or have no effect at all. It suggests participation of A-receptors. Adenosine is more effective than 8 other drugs that have protective effect in different models of brain ischemia (nimodipine, gamma-hydroxybutyrate etc).
Kulinskiĭ
V I
VI
Usov
L A
LA
Sufianova
G Z
GZ
D000241:Adenosine / Q000627:therapeutic use*; D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009705:Nucleosides / Q000627:therapeutic use; D009711:Nucleotides / Q000627:therapeutic use; D018047:Receptors, Purinergic P1 / Q000187:drug effects
D009705:Nucleosides; D009711:Nucleotides; D018047:Receptors, Purinergic P1; D000241:Adenosine
Zashchitnyĭ éffekt adenozina pri polnoĭ ishemii golovnogo mozga.