[Possible involvement of activation of pulmonary macrophages in respiratory failure with acute pancreatitis].
We examined the stimulatory state of pulmonary macrophages (Mø) in rats with caerulein-induced pancreatitis by measuring their activity for free radical production in vitro and in situ using nitroblue tetrazolium (NBT) under treatment of phorbol myristate acetate. The Mø from bronchoalveolar lavage were significantly activated 24 h after caerulein administration. The lung perfusion with NBT in the presence of PMA confirmed in situ that pulmonary Mø were also significantly activated in the same condition. Thereafter significant hypoxia was observed. These results indicate that the activation of pulmonary Mø may be involved in the respiratory failure in acute pancreatitis.
Haranomura
H
H
First Department of Surgery, Kobe University School of Medicine, Japan.
Takeyama
Y
Y
Toyokawa
A
A
Saito
Y
Y
D000208:Acute Disease; D000818:Animals; D008262:Macrophage Activation; D016676:Macrophages, Alveolar / Q000502:physiology*; D008297:Male; D009580:Nitroblue Tetrazolium; D010195:Pancreatitis / Q000150:complications*; D051381:Rats; D011916:Rats, Inbred F344; D012131:Respiratory Insufficiency / Q000209:etiology*
D009580:Nitroblue Tetrazolium