title: Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever.
abstract: Plasma penicillin levels were studied 2, 3, and 4 weeks after intramuscular benzathine penicillin G (BPG) doses of 1,200,000, 1,800,000, and 2,400,000 U. Proportions of patients with penicillin levels above 25 ng/ml at each week increased with increasing BPG dose. Further studies of higher-dose BPG for rheumatic fever prophylaxis are required.
authors.affiliation: Menzies School of Health Research, Darwin, Northern Territory, Australia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Currie
authors.forename: T
authors.initials: T
authors.lastname: Burt
authors.forename: E L
authors.initials: EL
authors.lastname: Kaplan
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010406:Penicillins / Q000097:blood*; D012213:Rheumatic Fever / Q000517:prevention & control*
chemical_list: D010406:Penicillins; D010401:Penicillin G Benzathine