Chloroquine resistant Plasmodium falciparum in coastal Tanzania. A challenge to the continued strategy of village based chemotherapy for malaria control.
An in vivo study to assess Plasmodium falciparum sensitivity to chloroquine was conducted in two villages of the Bagamoyo District, Tanzania in December 1992. The WHO standard field test (7 days) and the extended test (28 days) were carried out on symptom free children. The presence of chloroquine resistance was confirmed with 59% of infections being found resistant. Fifty-three percent were RI, 2% were at RII and 4% at RIII levels of resistance. Dosage was 25 mg/kg chloroquine base delivered over three days.
Premji
Z
Z
Muhimbili University College of Health Science, Dar es Salaam, Tanzania.
Minjas
J N
JN
Shiff
C J
CJ
D000818:Animals; D002648:Child; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D012494:Sampling Studies; D013636:Tanzania / Q000453:epidemiology; D014944:World Health Organization
D002738:Chloroquine