Real-time volume measurements in the isolated beating rat heart.
A new technique, utilizing scattered X-rays, has been developed that is capable of measuring isolated working rat heart left ventricular (LV) volumes continuously throughout the cardiac cycle. The technique was validated by comparing cardiac outputs measured via fluid collections (r = 0.959, n = 10). The new methodology will permit real-time measurements of pressure-volume relationships, stroke work, and indexes of diastolic function in the isolated working rat heart.
Waksman
D G
DG
Department of Medicine and Bioengineering, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
McInerney
J J
JJ
Herr
M D
MD
D000818:Animals; D002302:Cardiac Output; D003971:Diastole; D005069:Evaluation Studies as Topic; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D016277:Ventricular Function, Left