Cardiopulmonary adaptations to pneumonectomy in dogs. III. Ventilatory power requirements and muscle structure.
Static and dynamic mechanical characteristics of the respiratory system were measured in five adult foxhounds 6-15 mo after right pneumonectomy (R-PNX) and in five matched foxhounds that underwent right thoracotomy without pneumonectomy (Sham). In R-PNX dogs, elastic recoil was lower than that in the left lung of Sham dogs. On exercise, absolute ventilatory power requirements of the lung and its components were measured, i.e., power requirements to overcome elastic and viscous resistances of the lung as well as power requirements during inspiration and expiration. All components were higher for a given minute ventilation in R-PNX dogs than in both lungs of Sham dogs. Ventilatory power requirements after R-PNX were also higher than in three adult foxhounds after left PNX studied previously by the same techniques. After R-PNX, the mass of the right costal diaphragm and total mass of inspiratory muscles were greater than in Sham dogs. There were no significant differences in ultrastructural features of the costal diaphragm. The unilateral increase in muscle mass is likely the result of chronic elevation and stretch of the right costal diaphragm after R-PNX.
Hsia
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.
Herazo
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LF
Ramanathan
M
M
Claassen
H
H
Fryder-Doffey
F
F
Hoppeler
H
H
Johnson
R L
RL
D000399:Air Pressure; D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D003964:Diaphragm / Q000033:anatomy & histology* / Q000502:physiology* / Q000648:ultrastructure; D004285:Dogs; D004734:Energy Metabolism / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008176:Lung Volume Measurements; D008297:Male; D009929:Organ Size / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology; D011013:Pneumonectomy; D015656:Respiratory Mechanics / Q000502:physiology*