title: Simulation of spatial and contrast distortions in keyhole imaging.
abstract: Keyhole imaging is a scheme introduced to improve temporal resolution in dynamic contrast-enhanced MRI by a factor of four or more. A "full" acquisition before contrast administration is followed by truncated acquisitions sensitive primarily to changes in image contrast. Simulations of the point-spread functions that obtain, and their effect on contrast and spatial resolution, reveal significant degradation only for the smallest objects. Our simulations also address the feasibility of three-dimensional keyhold imaging, and demonstrate a potential 16-fold increase in temporal resolution. This suggests roles for keyhole imaging in conventional (nondynamic) precontrast and postcontrast studies and other applications.
authors.affiliation: Department of Radiology, University of Virginia, Charlottesville 22908.
authors.forename: T A
authors.initials: TA
authors.lastname: Spraggins
mesh_terms: D003287:Contrast Media; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media