Escins-Ia, Ib, IIa, IIb, and IIIa, bioactive triterpene oligoglycosides from the seeds of Aesculus hippocastanum L.: their inhibitory effects on ethanol absorption and hypoglycemic activity on glucose tolerance test.
Five triterpene oligoglycosides named escins-Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of Aesculus hippocastanum L. and their chemical structures were determined on the basis of chemical and physicochemical evidence. Escins-Ia, Ib, IIa, and IIb were found to exhibit inhibitory effect on ethanol absorption and hypoglycemic activity on oral glucose tolerance test in rats. Among them, escins-IIa and IIb showed the higher activities for both bioassays, while desacylescins-I and II had no activity.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Harada
E
E
Murakami
T
T
Matsuda
H
H
Wariishi
N
N
Yamahara
J
J
Murakami
N
N
Kitagawa
I
I
D000818:Animals; D004928:Escin / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D000431:Ethanol / Q000493:pharmacokinetics*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D007004:Hypoglycemic Agents; D014315:Triterpenes; D000431:Ethanol; D004928:Escin