[Biotransformation of sodium nitroprusside in tumor-bearing animals].
The interaction of sodium nitroprusside with tissues of solid tumour bearing animals (S-180; S-Worker; spontaneous adenomatosis) have been studied in vivo by means of EPR-method. The tumour subjected animals in distinction from healthy animals elicits appearance of paramagnetic nitrosyl iron complexes in blood plasma. Thus, the previously found phenomenon of specific reaction of nitroprusside with ascitic forms of tumours is confirmed on solid tumours in vivo.
Demidov
M Ia
MIa
Kleshchev
A L
AL
Sedov
K R
KR
D011125:Adenomatous Polyposis Coli / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation / Q000502:physiology; D004578:Electron Spin Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009599:Nitroprusside / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012510:Sarcoma 180 / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000378:metabolism*
D009599:Nitroprusside
Osobennosti biotransformatsii nitroprussida natriia v organizme zhivotnykh-opukholenositeleĭ.