Multiple primary tumors in head and neck cancer: etiology and incidence.
Second primary tumors are an important and challenging problem in head and neck oncology. The reported incidence of multiple primary tumors varies from 5 to 30%. The majority of these second tumors occur in the aero-digestive tract. They are a major cause of failure in the treatment of head and neck cancer.
Dhooge
I J
IJ
Department of Otorhinolaryngology, University Hospital Ghent, Belgium.
Albers
F W
FW
D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors