title: Cerebral energy metabolism during hypoxia-ischemia correlates with brain damage: a 31P NMR study in unanesthetized immature rats.
abstract: The association between the ultimate brain damage resulting from unilateral hypoxic-ischemic insult (HI) and the changes in high-energy metabolites, measured by noninvasive phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy during the insult, was evaluated in 7-day postnatal rats. When the NMR metabolite levels were integrated over the last 1.5 h out of 2.5 h of HI, there was a significant correlation of both the estimator of phosphorylation potential (P < 0.001) and ATP levels (P < 0.01) with histologic score of damage and area morphometry. In particular, the development of cerebral infarction could be predicted from the NMR evaluation (P < 0.005). These findings suggest that a large disturbance in cellular energy metabolism is a prerequisite for the subsequent neuropathological alterations in this model.
authors.affiliation: Department of Radiology, Pennsylvania State University College of Medicine, Hershey 17033.
authors.forename: G D
authors.initials: GD
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Towfighi
authors.forename: M B
authors.initials: MB
authors.lastname: Smith
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry / Q000502:physiology*; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D017536:Carotid Artery, Common / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006651:Histocytochemistry; D006863:Hydrogen-Ion Concentration; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate