Time course of purine protection against kainate-induced increase in hippocampal [3H]-PK11195 binding.
Binding of a peripheral benzodiazepine receptor ligand was used to quantify the reactive gliosis resulting from neuronal damage induced by systemic injections of kainic acid 7 days previously. The enhancement of binding in rat hippocampus could be prevented by injections of the purine analogue (R)-N6-phenylisopropyladenosine at 25 microgram/kg up to 2 h before or after the toxin. These results indicate that the purine is able to prevent neurotoxicity by interrupting events occurring some time after kainate administration.
Miller
W J
WJ
Department of Pharmacology, University of Glasgow, Scotland.
MacGregor
D G
DG
Stone
T W
TW
D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007546:Isoquinolines / Q000378:metabolism*; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D008297:Male; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014316:Tritium
D007546:Isoquinolines; D014316:Tritium; D010660:Phenylisopropyladenosine; D007608:Kainic Acid; C037850:PK 11195