Mosquito repellency & toxicity of isomeric N, N-diethyltolylacetamides.
Three isomers of N, N-diethyltolylacetamides were synthesized and evaluated against Aedes aegypti and Culex quinquefasciatus for repellency and with mice for LD50, as an indicator of mammalian toxicity. Of these, N, N-diethyl-p-tolylacetamide (DEPTA) showed comparatively better repellency against C. quinquefasciatus. All the compounds showed higher repellency against C. quinquefasciatus than Ae. aegypti. In addition, N, N-diethyl-m-tolylacetamide (DEMTA) was found to be least toxic to mice.
Sikder
N
N
Defence R & D Establishment, Gwalior.
Gopalan
N
N
Prakash
S
S
Vinod
V K
VK
Rao
S S
SS
Rao
K M
KM
D000081:Acetamides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000330:Aedes; D000818:Animals; D003465:Culex; D005260:Female; D007302:Insect Repellents / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013237:Stereoisomerism
D000081:Acetamides; D007302:Insect Repellents