Clinical and experimental studies in myocarditis.
We review recent manuscripts concerning the pathogenesis as well as the treatment of myocarditis. The development of myocarditis is related to inflammatory cell infiltration, progressive and additive focal cellular necrosis, and associated reactive myocardial fibrosis. These processes may be initiated and perpetuated by autoimmune factors, including cytokines, and by alterations in the myocardial microcirculation. This has implications for the development of future therapeutic strategies for patients with myocarditis, strategies that will enable physicians to optimize medical treatment and, hopefully, to improve the prognosis.
Kishimoto
C
C
Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Hiraoka
Y
Y
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000473:pathology / Q000628:therapy; D016207:Cytokines / Q000502:physiology; D004699:Endocardium / Q000473:pathology; D015658:HIV Infections / Q000150:complications / Q000473:pathology / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive; D009205:Myocarditis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism
D001323:Autoantibodies; D016207:Cytokines; D017382:Reactive Oxygen Species