title: Early blastic transformation of a myeloproliferative disorder with t(8;21) and progressive aberrations of chromosome 8.
abstract: We describe a case of a patient affected by a chronic myeloproliferative disorder with t(8;21)(q22;q22) and trisomy 8 at diagnosis. At the time of blastic metamorphosis, 2 months later, trisomy 8 metaphases were significantly reduced, while a predominance of t(8;21) was present. Finally, in the phase of leukemic regrowth following chemotherapy administration, monosomy 8 associated with der(21)t(8;21) was the predominant cytogenetic abnormality.
authors.affiliation: Division of Hematology, Cardarelli General Hospital, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fasanaro
authors.forename: G
authors.initials: G
authors.lastname: Paone
authors.forename: I
authors.initials: I
authors.lastname: Silvestri
authors.forename: V
authors.initials: V
authors.lastname: Marottoli
authors.forename: R
authors.initials: R
authors.lastname: Cimino
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
mesh_terms: D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009006:Monosomy; D014178:Translocation, Genetic; D014314:Trisomy