[Rat survival and mitochondrial ratio of free NAD+/NADH in the liver under the effect of ionizing radiation and sodium succinate].
Free NAD+/NADH mitochondrial ratio in rat liver increased 4-12 days after whole-body animal exposure to 4 Gy but decreased to normal value at days 16-20. The administration of sodium succinate led to normalization of NAD+/NADH ratio during first few days after irradiation and increased animal survival after sublethal dose of radiation.
Kosenko
E A
EA
Kaminskiĭ
Iu G
IuG
D000818:Animals; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects*; D009243:NAD / Q000032:analysis*; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000494:pharmacology*; D019802:Succinic Acid; D013997:Time Factors; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D013386:Succinates; D009243:NAD; D019802:Succinic Acid
Vyzhivaemost' krys i mitokhondrial'noe otnoshenie svobodnykh NAD+/NADH v pecheni pri deĭstvii ioniziruiushchego izlucheniia i suktsinata natriia.