Enhanced T cell migration to sites of microscopic CNS disease: complementary treatments evaluated by 2- and 3-D image analysis.
Novel therapies are being developed to attack tumour or other abnormal cells within the brain. A general problem is the need for delivery to sites of microscopic disease. Leukocytes offer an attractive solution; they are able to both move through tissue and recognize abnormal targets. Leukocytes may act as effectors, or as vehicles for drugs, retroviral vectors or other agents. Here, we illustrate complementary ways of enhancing leukocyte migration to sites of microscopic central nervous system (CNS) disease. Enhanced T cell migration to sites of disseminated tumour is used as the example. Computer-assisted image analysis is used to evaluate migration patterns in 2 and 3 dimensions. Shared regulatory features in the migration of tumour and responding cells, and the opportunities and questions they imply, are discussed.
Lampson
L A
LA
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Chen
A
A
Vortmeyer
A O
AO
Sloan
A E
AE
Ghogawala
Z
Z
Kim
L
L
D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology*; D001932:Brain Neoplasms / Q000473:pathology; D002465:Cell Movement; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016246:Lymphocytes, Tumor-Infiltrating / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*