Intestinal permeability in patients with Crohn's disease and their first-degree relatives.
OBJECTIVE
To measure small intestinal permeability in a group of patients with Crohn's disease in clinical remission and their apparently healthy first-degree relatives.


METHODS
Administration of 51Cr-labeled EDTA and subsequent measurement of its excretion in a 24-h urine collection.


RESULTS
Excretion of 51Cr-EDTA was not elevated in either the patients or in first-degree relatives.


CONCLUSIONS
Intestinal permeability to 51Cr-EDTA is not raised in patients with Crohn's disease in clinical remission or in their healthy first-degree relatives.
Howden
C W
CW
Stobhill General Hospital, Glasgow, Scotland, United Kingdom.
Gillanders
I
I
Morris
A J
AJ
Duncan
A
A
Danesh
B
B
Russell
R I
RI
D002860:Chromium Radioisotopes; D003424:Crohn Disease / Q000235:genetics / Q000503:physiopathology*; D004492:Edetic Acid; D006801:Humans; D007408:Intestinal Absorption / Q000235:genetics* / Q000502:physiology; D007421:Intestine, Small / Q000502:physiology*
D002860:Chromium Radioisotopes; D004492:Edetic Acid