Nephrogenic diabetes insipidus associated with bilateral ureteral obstruction.
Nephrogenic diabetes insipidus associated with ureteral obstruction is rare. We report a case of nephrogenic diabetes insipidus associated with ureteral obstruction caused by ileal leiomyosarcoma in a 32-year-old man. The treatment with trichlorothiazide and diclofenac sodium reduced urine output from 8 L/day to 4 L/day. Six months after nephrostomy, urine output decreased to 2.5 L/day without any drug administration. This case suggests that ureteral obstruction may cause an increase in urine output to 8 L/day and that surgical treatment for ureteral obstruction is effective in reducing urine output in nephrogenic diabetes insipidus patients with ureteral obstruction.
Kato
A
A
First Department of Medicine, Hamamatsu University School of Medicine.
Hishida
A
A
Ishibashi
R
R
Nakajima
T
T
Ohura
M
M
Furuya
R
R
Kumagai
H
H
Kimura
M
M
Kaneko
E
E
D000328:Adult; D002740:Chlorothiazide / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000150:complications* / Q000188:drug therapy; D004008:Diclofenac / Q000627:therapeutic use; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy; D007890:Leiomyosarcoma / Q000150:complications; D008297:Male; D011141:Polyuria / Q000150:complications / Q000188:drug therapy; D014517:Ureteral Obstruction / Q000150:complications* / Q000209:etiology / Q000601:surgery
D004008:Diclofenac; D002740:Chlorothiazide