title: [The assessment of the local immune reaction of the mucosa of the large intestine in patients with nonspecific ulcerative colitis].
abstract: The article presents data on the features of local immune reaction in lamina propria of colonic mucosa in patients with severe unspecific ulcerous colitis. Identification of immunocompetent cells with monoclonal antibodies, considered the most effective method to date, was used in the study. Number of immunocompetent cells in lamina propria of colonic mucosa was established to be significantly higher in patients with severe UUC as compared to that of the control group, subpopulations of B-lymphocytes prevailing. Production of all immunoglobulins, especially of IgG, was increased. This evidences sharp activation of local immune reaction and attempt of the body to strengthen both first and second lines of immune protection in colonic mucosa.
authors.forename: L V
authors.initials: LV
authors.lastname: Dudar'
authors.forename: N G
authors.initials: NG
authors.lastname: Bychkova
mesh_terms: D000917:Antibody Formation; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000276:immunology* / Q000473:pathology; D003106:Colon / Q000002:abnormalities; D006801:Humans; D007111:Immunity, Cellular; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D007420:Intestine, Large / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
vernacular_title: Otsenka sostoianiia mestnoĭ immunnoĭ reaktsii slizistoĭ obolochki tolstoĭ kishki u bol'nykh nespetsificheskim iazvennym kolitom.