title: [Allergic myocarditis in clozapine treatment].
abstract: Clozapine is a high-dose neuroleptic, which is recommended only for those cases in which patients have failed to respond adequately to standard antipsychotic drugs. This report describes a 45 year old man with ischaemic heart disease who died of cardiogenic shock 11 days after starting treatment with clozapine. Autopsy showed apart from coronary atherosclerosis and interstitial fibrosis a considerable infiltration of eosinophilic granulocytes in the myocardium suggesting myocarditis as the cause of death.
authors.affiliation: Patologisk institut, Arhus Amtssygehus.
authors.forename: V E
authors.initials: VE
authors.lastname: Jensen
authors.forename: O
authors.initials: O
authors.lastname: Gøtzsche
mesh_terms: D003024:Clozapine / Q000009:adverse effects*; D004562:Electrocardiography; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D009206:Myocardium / Q000473:pathology
chemical_list: D003024:Clozapine
vernacular_title: Allergisk myocarditis ved klozapinbehandling.