title: Oral lesions among HIV-infected hemophiliacs. A study of 54 patients.
abstract: BACKGROUND
  HIV-infected individuals develop a large variety of oral manifestations. This study was designed to assess the prevalence and types of oral lesions among HIV-positive hemophiliacs.
  
  
  METHODS
  A study population of 54 hemophiliacs was evaluated from February, 1987 to March, 1992 in order to analyze types, prevalence and relationships to clinical stages of HIV-related oral lesions. Thirty-six (67%) of the group of patients were HIV seropositive. The remaining 18 tested negative to HIV during the observation period.
  
  
  RESULTS
  The majority of patients suffered from hemophilia A. One patient was also bisexual and two were also intravenous drug abusers. Analysis of patient stage revealed that half had a CD4+ T-lymphocyte count over 0.5 x 10(9)/L cells, 10 between 0.2 and 0.499 x 10(9)/L and 8 showed a count lower than 200 x 10(9)/L. Oral lesions were recorded in 18 (50%) HIV-seropositive hemophiliacs. No oral lesions were observed among the HIV-seronegative hemophiliacs. Advanced stage of immunosuppression and presence of oral lesions were significantly associated (p = 0.040). Candidiasis was the most common disturbance, followed by hairy leukoplakia. Oral herpes simplex infection, necrotizing gingivitis and facial herpes zoster were found in a small number of patients. Those with oral lesions showed a lower median CD4+ T lymphocyte count (0.209 x 10(9)/L cells; range 0.008 to 0.615) when compared to the ones without oral lesions (median CD4+ count was 0.539 x 10(9)/L cells; range 0.042 to 1.180; p = 0.002).
  
  
  CONCLUSIONS
  HIV-seropositive hemophiliacs may develop oral lesions during the course of their disease. Candidiasis and hairy leukoplakia are among the most common manifestations. A careful oral examination should be included in the clinical evaluation of all HIV-infected hemophiliacs.
authors.affiliation: Institute of Odontology and Stomatology, University of Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ficarra
authors.forename: M
authors.initials: M
authors.lastname: Chiodo
authors.forename: M
authors.initials: M
authors.lastname: Morfini
authors.forename: G
authors.initials: G
authors.lastname: Longo
authors.forename: A
authors.initials: A
authors.lastname: Orsi
authors.forename: S
authors.initials: S
authors.lastname: Piluso
authors.forename: D
authors.initials: D
authors.lastname: Rafanelli
mesh_terms: D006679:HIV Seropositivity / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D065227:Transfusion Reaction