The patellar tendon graft for PCL reconstruction. Morphological aspects in a sheep model.
Surgical reconstruction of the PCL has not yet gained the acceptance that ACL reconstruction has achieved. However, in selecting an autograft to restore PCL function in symptomatic posterior knee instability, the free patellar tendon autograft is commonly used at present. Knowledge of the basics in graft healing and of factors regulating this healing process are still limited. It is of interest to determine the biologic response and final morphology of a patellar tendon autograft after PCL replacement. Based on morphological studies in PCL replacement in a sheep model the patellar tendon autograft under-goes necrosis and degeneration followed by a gradual healing process comprising revitalization (i.e. revascularization and cellular proliferation), formation of extracellular matrix components and remodeling. The autograft bone pegs become osseointegrated by 6 weeks. After 2 years, the autograft tissue differs structurally from a ligament, suggesting that the autograft may never approach normal ligament characteristics. Degenerative alterations in the core region of the autograft, the widespread presence of type III collagen and fibronectin, as well as the predominance of thin collagen fibrils do not favor a ligamentization process. The understanding of the autograft healing process remains the prerequisite for a realistic assessment of the biologic PCL replacement and will be a baseline of studies with the goal of influencing the healing process and thus improving the clinical results.
Bosch
U
U
Department of Trauma Surgery, Hannover Medical School, Hannover, Germany.
Kasperczyk
W J
WJ
Oestern
H J
HJ
Tscherne
H
H
D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D002455:Cell Division; D003094:Collagen / Q000032:analysis; D005109:Extracellular Matrix / Q000737:chemistry; D005353:Fibronectins / Q000032:analysis; D016348:Osseointegration; D017847:Patellar Ligament / Q000637:transplantation*; D016119:Posterior Cruciate Ligament / Q000166:cytology / Q000601:surgery*; D012756:Sheep; D014182:Transplantation, Autologous
D005353:Fibronectins; D003094:Collagen