title: Analysis of repetitive and nonrepetitive sequential arm movements in patients with Parkinson's disease.
abstract: We examined the motor performance of Parkinson's disease patients and normal subjects during nonrepetitive and repetitive sequential tasks. Parkinson's disease patients took longer than normal subjects to complete the nonrepetitive task, the sequential drawing of a pentagon. In patients, movement times lengthened as the sequence neared completion. The amount of lengthening was similar in nonrepetitive and repetitive tasks (sequential alternating drawing of each side of the pentagon). In parkinsonian patients the slowing at the end of the sequential tasks does not appear to be influenced by whether the sequential task involves nonrepetitive or repetitive movements.
authors.affiliation: Department of Neurological Sciences, University of Rome La Sapienza, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Agostino
authors.forename: A
authors.initials: A
authors.lastname: Berardelli
authors.forename: A
authors.initials: A
authors.lastname: Formica
authors.forename: F
authors.initials: F
authors.lastname: Stocchi
authors.forename: N
authors.initials: N
authors.lastname: Accornero
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
mesh_terms: D000328:Adult; D000368:Aged; D003342:Corpus Striatum / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D013378:Substantia Nigra / Q000503:physiopathology
chemical_list: D004298:Dopamine