fimA-folD genes linkage in Salmonella identifies a putative junctional site of chromosomal rearrangement in the enterobacterial genome.
Analysis of the Salmonella chromosomal region located upstream of the fimA gene (coding for the major type 1 fimbrial subunit) showed a close linkage of this gene to the folD gene (coding for the enzyme 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase), indicating that the fim gene cluster of Salmonella, unlike that of Escherichia coli, has no regulatory genes located upstream of fimA and apparently terminates with this gene. The respective locations of the fim and folD genes in the E. coli and Salmonella genetic maps suggests that the fimA-folD intergenic region of Salmonella encompasses a junctional site of a genetic rearrangement that probably originated from the different chromosomal location of the fim genes in these species.
Rossolini
G M
GM
Dipartimento di Biologia Molecolare, Università di Siena, Italy.
Muscas
P
P
Chiesurin
A
A
Satta
G
G
D000595:Amino Acid Sequence; D000619:Aminohydrolases / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D017124:Conserved Sequence; D036781:Fimbriae Proteins; D015321:Gene Rearrangement / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D016678:Genome; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics*; D005810:Multigene Family / Q000235:genetics; D012475:Salmonella / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D001426:Bacterial Proteins; D009097:Multienzyme Complexes; C063055:fimbrillin; C055342:methylene tetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase; D036781:Fimbriae Proteins; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D000619:Aminohydrolases