title: Comparison of the inflammatory response to particulate polymethylmethacrylate debris with and without barium sulfate.
abstract: Particulate polymethylmethacrylate debris has been implicated in the inflammatory response observed surrounding loosened cemented implants. The rat subcutaneous pouch model and the Howie implant model (used to study bone resorption) were used to quantify the response to mechanically produced endotoxin-free polymethylmethacrylate debris with and without 10% (wt/vol) BaSO4. In the rat subcutaneous pouch model, the inflammatory response to polymethylmethacrylate particles containing BaSO4 was greater than the response to plain polymethylmethacrylate particles of similar size. Increased inflammation was measured by leukocyte counts and levels of prostaglandin E2, tumor necrosis factor, and neutral metalloprotease. In addition, particulate polymethylmethacrylate with BaSO4 caused significantly greater bone resorption in the Howie model than did particulate plain polymethylmethacrylate. In in vitro studies, particulate polymethylmethacrylate with BaSO4 stimulated more prostaglandin E2, neutral metalloprotease, and tumor necrosis factor from human monocytes in culture and stimulated greater proliferation of synovial cells than did particulate plain polymethylmethacrylate. The presence of BaSO4 appears to significantly intensify the inflammatory response to polymethylmethacrylate debris.
authors.affiliation: Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: M D
authors.initials: MD
authors.lastname: Lazarus
authors.forename: J M
authors.initials: JM
authors.lastname: Cuckler
authors.forename: H R
authors.initials: HR
authors.lastname: Schumacher
authors.forename: P
authors.initials: P
authors.lastname: Ducheyne
authors.forename: D G
authors.initials: DG
authors.lastname: Baker
mesh_terms: D000818:Animals; D001466:Barium Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D015232:Dinoprostone / Q000032:analysis / Q000378:metabolism; D003875:Drug Eruptions / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004347:Drug Interactions; D006801:Humans; D007279:Injections, Subcutaneous; D007958:Leukocyte Count; D008297:Male; D008768:Methylmethacrylates / Q000008:administration & dosage / Q000009:adverse effects*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000378:metabolism
chemical_list: D008768:Methylmethacrylates; D014409:Tumor Necrosis Factor-alpha; D001466:Barium Sulfate; D015232:Dinoprostone