The role of apolipoprotein E in the nervous system.
Human apolipoprotein (apo)E, an important component of plasma lipoprotein metabolism, was recently linked to Alzheimer's disease. Of the three common apoE alleles, epsilon 4 has emerged as a major risk factor. This review summarizes the data leading to this conclusion and discusses possible mechanisms for apoE involvement based on recent biochemical studies.
Weisgraber
K H
KH
Gladstone Institute of Cardiovascular Disease, San Francisco, California.
Roses
A D
AD
Strittmatter
W J
WJ
D000544:Alzheimer Disease / Q000209:etiology; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009424:Nervous System Physiological Phenomena; D016875:tau Proteins / Q000378:metabolism
D001057:Apolipoproteins E; D016875:tau Proteins