Antitumor effect of locally injected low doses of recombinant human interleukin-2 in bovine vulval papilloma and carcinoma.
In many human clinical trials and in various animal tumor models, the antitumor effect of high doses of systemically applied interleukin-2 (IL-2) is tested. Our studies focused on the effects of low doses of locally injected IL-2. In this paper, the effect of local injection of low doses of IL-2, i.e. a total dose of 25,000-50,000 units, into papillomas or carcinomas of the bovine vulva is described. In 19 out of 23 (83%) cows treated with IL-2 an effect on the tumor load was observed; in three of these animals, complete regression was obtained. In the majority of cases, regression was not restricted to the tumors injected with IL-2.
Hill
F W
FW
Department of Clinical Veterinary Studies, Faculty of Veterinary Science, University of Zimbabwe, Mount Pleasant, Harare.
Klein
W R
WR
Hoyer
M J
MJ
Rutten
V P
VP
Kock
N
N
Koten
J W
JW
Steerenberg
P A
PA
Ruitenberg
E J
EJ
Den Otter
W
W
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D007167:Immunotherapy / Q000662:veterinary; D015552:Injections, Intralesional / Q000662:veterinary; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D010212:Papilloma / Q000188:drug therapy / Q000662:veterinary*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction; D014846:Vulvar Neoplasms / Q000188:drug therapy / Q000662:veterinary*
D007376:Interleukin-2; D011994:Recombinant Proteins