title: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.
authors.affiliation: Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
authors.forename: R E
authors.initials: RE
authors.lastname: Dolle
authors.forename: J A
authors.initials: JA
authors.lastname: Dunn
authors.forename: M
authors.initials: M
authors.lastname: Bobko
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: J E
authors.initials: JE
authors.lastname: Kuster
authors.forename: E
authors.initials: E
authors.lastname: Baizman
authors.forename: A L
authors.initials: AL
authors.lastname: Harris
authors.forename: D G
authors.initials: DG
authors.lastname: Sawutz
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: S
authors.initials: S
authors.lastname: Wang
mesh_terms: D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D010766:Phosphorylation; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D011804:Quinolines; C088968:5,7-dimethoxy-3-(4-pyridinyl)quinoline; D020794:Receptor Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor