title: High-performance liquid chromatographic method for the enantioselective analysis of mefloquine in plasma and urine.
abstract: An HPLC method for analysis of the enantiomers of the antimalarial drug mefloquine is presented. A complete resolution of (-)-(11S,2'R) and (+)-(11R,2'S) erythro-mefloquine from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers were detected by UV at 222 nm. The separation factor (alpha) at +20 degrees C was 1.50. The limit of determination (coefficient of variation 4.0%) for the enantiomeric ratio (11S,2'R)/(11R,2'S) is 15:1 at a total mefloquine concentration of 1.6 mM.
authors.affiliation: Hospital Pharmacy, Southern Hospital, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Wallén
authors.forename: O
authors.initials: O
authors.lastname: Ericsson
authors.forename: I
authors.initials: I
authors.lastname: Wikström
authors.forename: U
authors.initials: U
authors.lastname: Hellgren
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015767:Mefloquine / Q000032:analysis* / Q000097:blood / Q000652:urine; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D015767:Mefloquine