Nitrofurantoin-induced pulmonary hemorrhage in a renal transplant recipient receiving immunosuppressive therapy: case report and review of the literature.
A 33-year-old woman received a cadaveric renal transplant for focal segmental glomerulosclerosis. Nitrofurantoin urinary prophylaxis was started on postoperative day 13 but coughing and mild hemoptysis began 2 days later. Diffuse infiltrates and worsening hemoptysis led to intubation and open lung biopsy. Clinical course, culture results and pathological evaluation excluded infectious etiologies and were consistent with a drug reaction. The case is described, and the literature on the nitrofurantoin pulmonary toxicity syndromes and pathophysiology is reviewed.
Meyer
M M
MM
Division of Nephrology, Oregon Health Sciences University, Portland 97201.
Meyer
R J
RJ
D000328:Adult; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000601:surgery; D006469:Hemoptysis / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008171:Lung Diseases / Q000139:chemically induced*; D009582:Nitrofurantoin / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D009582:Nitrofurantoin