Mitomycin C induced inhibition of adrenal steroidogenesis in female rats.
Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase (delta 5 3 beta OHD) and glucose-6 phosphate dehydrogenase (G-6 PD) in the rat adrenal tissue. The treatment resulted in a fall in DNA content together with an accumulation of cholesterol and ascorbic acid in the gland. The results suggest a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.
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Department of Physiology, University College of Science, Calcutta.
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D042842:11-beta-Hydroxysteroid Dehydrogenases; D000311:Adrenal Glands / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D016685:Mitomycin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D016685:Mitomycin; D004247:DNA; D002784:Cholesterol; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D005954:Glucosephosphate Dehydrogenase; D001205:Ascorbic Acid