[Inhibition of mammary gland carcinogenesis using a tincture from biomass of ginseng tissue culture].
The influence of official drug bioginseng produced from cultivated cells of ginseng radix (Panax ginseng C. A. Mey) on carcinogenesis of the mammary gland was studied. Adenocarcinomas of the mammary gland were induced in rats by single intramammary injections of N-methyl-N-nitrosourea (MNU) at a dose of 1 mg per gland into the tissues of all 12 mammary glands. Bioginseng was given per os at a daily dose of 0.5 ml per rat for 27 weeks beginning 1 week after the MNU administration. Bioginseng and the control MNU-group decreased the incidence and multiplicity of the mammary gland tumors at 44 and 62% respectively. By radioimmune assay it was found that bioginseng normalised abnormally high level of estradiol in blood of rats treated by MNU.
Bespalov
V G
VG
Aleksandrov
V A
VA
Davydov
V V
VV
Limarenko
A Iu
AIu
Molokovskiĭ
D S
DS
Petrov
A S
AS
Slepian
L I
LI
Trilis
Ia G
IaG
D000230:Adenocarcinoma / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D004958:Estradiol / Q000097:blood; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008770:Methylnitrosourea; D005894:Panax; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D010936:Plant Extracts; D004958:Estradiol; D008770:Methylnitrosourea
Podavlenie kantserogeneza molochnoĭ zhelezy s pomoshch'iu nastoĭki iz biomassy kul'tury tkani zhen'shenia.