The evolution of kinetoplastid glycosomes.
The available data on carbohydrate metabolism in Kinetoplastida have been reviewed. Based on the metabolic pattern of different kinetoplastid organisms, on the subcellular distribution of their glycolytic enzymes, and on the structural and regulatory properties of these proteins, we propose that the glycosome developed from an endosymbiont, as a specific manner to control carbohydrate and energy metabolism. It is discussed how the enzymes were subcellularly recompartmentalized during evolution as adaptation to the environment encountered by the organisms.
Michels
P A
PA
Research Unit for Tropical Diseases, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
Hannaert
V
V
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D050260:Carbohydrate Metabolism; D002451:Cell Compartmentation; D004734:Energy Metabolism; D006019:Glycolysis; D007527:Isoenzymes / Q000378:metabolism; D016830:Kinetoplastida / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D008830:Microbodies / Q000378:metabolism; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000235:genetics / Q000378:metabolism
D007527:Isoenzymes; D009842:Oligopeptides; D021382:Protein Sorting Signals; C088449:seryl-lysyl-leucine