The preparation and in vivo activity of L- and D-O-methyl-methioninedichloroplatinum(II). The crystal structure of the L-enantiomer.
The L and D enantiomers of O-methylmethioninedichloroplatinum(II), chosen for their potential to bind to the GpA sequence of DNA, were prepared and their in vivo activities were measured. Against P388 leukemia both enantiomers showed moderate activity, T/C 128 and 147% for L and D, respectively. Both were inactive against L1210 leukemia and B16 melanoma. The crystal structure of [Pt(O-methyl-L-methionine)Cl2] has been determined by x-ray diffraction methods and refined to a residual of 0.021 for 1299 independent observed reflections. The crystals are monoclinic, space group P2(1); a, 8.698(2); b, 7.124(1); c, 9.198(3) A; beta, 96.71(2) degrees.
Hambley
T W
TW
Department of Inorganic Chemistry, University of Sydney, Australia.
Webster
L K
LK
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D003460:Crystallization; D018360:Crystallography, X-Ray; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C088780:O-methyl-methionine-dichloroplatinum(II)