[Disorders of immunologic response in mice under prolonged radiation effects and possibilities of their correction with alpha-interferon].
Reduction in effectoral functions of macrophages and natural killers in CBA mice exposed within the 30-km zone of Chernobyl station for 6 months was found. Disturbance in production of regulatory mediators such as IL-1, TNF and interferons, participating in cell immunity was also observed. Single application of alpha-interferon in a dose of 10(3) U/mouse results in partial or full restoring of immune characteristics disturbed.
Ganova
L A
LA
Slivak
N Ia
NIa
Olevinskaia
Z M
ZM
D000059:Accidents; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D016898:Interferon-alpha / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009688:Nuclear Reactors; D014455:Ukraine
D016898:Interferon-alpha
Narushenie immunologicheskoĭ reaktivnosti u mysheĭ pri dlitel'nom radiatsionnom vozdeĭstvii i vozmozhnost' ee korrektsii alfa-interferonom.