title: Applications of capillary electrophoresis in the eye-care pharmaceutical industry.
abstract: The speed and resolution of capillary electrophoresis (CE), combined with its low cost and low volume requirements, make it a promising method of separating eye-care pharmaceuticals and analyzing the ionic composition of tears. Capillary zone electrophoresis (CZE) offers linearity, precision, and recovery comparable to high-performance liquid chromatography (HPLC) at a fraction of its cost. In addition, CZE separates and quantitates cocoamphocarboxyglycinate in the presence of a non-ionic fatty acid amide surfactant seven times faster than HPLC. CE easily detects such cations as sodium and potassium in human tears.
authors.affiliation: Allergan Optical, Irvine, CA 92715-2002.
authors.forename: R R
authors.initials: RR
authors.lastname: Chadwick
authors.forename: J C
authors.initials: JC
authors.lastname: Hsieh
authors.forename: K S
authors.initials: KS
authors.lastname: Resham
authors.forename: R B
authors.initials: RB
authors.lastname: Nelson
mesh_terms: D000111:Acetylcysteine / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004345:Drug Industry; D004586:Electrophoresis / Q000379:methods; D006801:Humans; D009883:Ophthalmic Solutions / Q000032:analysis*; D013666:Tears / Q000737:chemistry
chemical_list: D009883:Ophthalmic Solutions; D000111:Acetylcysteine