title: Analysis of immunoglobulin isotype levels in acute pneumococcal bacteremia and in convalescence.
abstract: In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum sample was analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35%) patients had reduced levels of total IgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18%) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with a history of bacteremic pneumococcal infection.
authors.affiliation: Department of Infectious Diseases, Lund University Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Ekdahl
authors.forename: J
authors.initials: J
authors.lastname: Rollof
authors.forename: V A
authors.initials: VA
authors.lastname: Oxelius
authors.forename: J
authors.initials: J
authors.lastname: Engellau
authors.forename: J H
authors.initials: JH
authors.lastname: Braconier
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000097:blood / Q000209:etiology / Q000276:immunology*; D003289:Convalescence; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007132:Immunoglobulin Isotypes / Q000032:analysis* / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000097:blood / Q000209:etiology / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M