[Aldosterone receptors of the rat kidney in sciatic nerve injury and various mechanisms for their regulation].
It was shown, that the lesion of the sciatic nerve leads to disturbance of functioning of mineralocorticoid receptors of kidneys, which was expressed primarily as deterioration of the Na+ reabsorption in the kidneys ductulus cells. Simultaneous pharmacological blockade by propranolol's injections of neuroconductive and humoral pathways of transmission to the kidneys of pathological stimulus, caused in result of chronic irritation of sciatic nerve, prevents the development of disturbance in kidney's mineralocorticoid receptor apparatus functioning to a more extent, than the blockade of the neuroconductive pathway only. The obtained results point out that propranolol is a substance, which may prevent the development of neurogenic dystrophies.
Akimov
Iu A
IuA
D000042:Absorption; D000818:Animals; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018161:Receptors, Mineralocorticoid / Q000378:metabolism*; D012584:Sciatic Nerve / Q000293:injuries*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D018161:Receptors, Mineralocorticoid; D011433:Propranolol
Retseptiia al'dosterona pochkoĭ krys pri povrezhdenii sedalishchnogo nerva i nekotoye mekhanizmy ee reguliatsii.