title: Synthesis and anticancer activity of new phenyl-ring substituted 4-morpholino-1-phenylthio-2-butanones [Mannich bases].
abstract: The preparation of phenyl-ring substituted 4-morpholino-1-phenylthio-2-butanones 4a-e is described. These compounds were evaluated against P-388 leukemia and human cancer rhinopharynx KB cells in vitro; some compounds were found to exhibit activity against these cell lines.
authors.affiliation: Department of Pharmaceutical Chemistry and of Pharmacognosy, University of Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Siatra-Papastaikoudi
authors.forename: A
authors.initials: A
authors.lastname: Tsotinis
authors.forename: I
authors.initials: I
authors.lastname: Chinou
authors.forename: C
authors.initials: C
authors.lastname: Roussakis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002074:Butanones / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D002074:Butanones; D008352:Mannich Bases