[Effects of Epimedium sagittatum on immunopathology and extracellular matrices in rats with chronic renal insufficiency].
Chinese herb medicine, Epimedium sagittatum (EP), was used to treat animal models of chronic renal insufficiency induced in Wistar rats with 7/8 nephrectomy. The results showed: 1. EP decreased significantly the level of BUN and serum creatinine in the rats. 2. EP inhibited the hypertrophy of glomeruli in the rats. 3. EP inhibited deposition of IgG, C3, Fib and FN along the glomerular capillary walls in these rats.
Cheng
Q L
QL
Department of Nephrology, General Hospital of Chinese PLA, Beijing.
Chen
X M
XM
Shi
S Z
SZ
D000818:Animals; D003176:Complement C3 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005109:Extracellular Matrix / Q000276:immunology*; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D015200:Fluoroimmunoassay; D007074:Immunoglobulin G / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D003176:Complement C3; D004365:Drugs, Chinese Herbal; D005353:Fibronectins; D007074:Immunoglobulin G