Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?
This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.
Bellazzi
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R
Dipartimento di Informatica e Sistemistica, Università di Pavia, Italy.
Siviero
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C
Bellazzi
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D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D003362:Cost-Benefit Analysis; D004921:Erythropoietin / Q000627:therapeutic use*; D006801:Humans; D015233:Models, Statistical; D014511:Uremia / Q000150:complications
D004921:Erythropoietin