Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology.
The retrovirus LP-BM5 murine leukemia virus induces murine AIDS in C57BL/6 mice that has many similarities with human AIDS; Plasmodium berghei ANKA causes experimental cerebral malaria in the same strain of mice. The outcome of malaria infection was studied in mice concurrently infected with the two pathogens. The retrovirus significantly reduced the gravity of the neurological manifestations associated with Plasmodium berghei ANKA infection. The protection against experimental cerebral malaria induced by murine AIDS increased with duration of viral infection and, hence, with the severity of the immunodeficiency. Interleukin 10, principally from splenic T cells, was shown to play a crucial role in this protection.
Eckwalanga
M
M
Institut National de la Santé et de la Recherche Médicale, Unité 313, Département de Parasitologie, Paris, France.
Marussig
M
M
Tavares
M D
MD
Bouanga
J C
JC
Hulier
E
E
Pavlovitch
J H
JH
Minoprio
P
P
Portnoï
D
D
Rénia
L
L
Mazier
D
D
D000818:Animals; D001483:Base Sequence; D015704:CD4 Antigens / Q000032:analysis*; D017931:DNA Primers; D003673:Defective Viruses / Q000302:isolation & purification; D005260:Female; D016679:Genome, Viral; D006801:Humans; D016753:Interleukin-10 / Q000494:pharmacology*; D009052:Leukemia Virus, Murine / Q000302:isolation & purification; D008213:Lymphocyte Activation; D016779:Malaria, Cerebral / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D010962:Plasmodium berghei; D016133:Polymerase Chain Reaction; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*
D015704:CD4 Antigens; D017931:DNA Primers; D016753:Interleukin-10