title: Failure of terfenadine as an antipruritic agent in atopic dogs: results of a double-blinded, placebo-controlled study.
abstract: Terfenadine (5 mg/kg body weight, q12h) and placebo (0.5 grain/dog q12h) were both administered orally as individual agents to 18 dogs with atopy in a double-blinded study. No dog improved. Hyperactivity, polyphagia, lethargy, anorexia, increased pruritus, or ocular discharge were seen in three dogs treated with terfenadine. Under the conditions of the study, terfenadine was not a useful antipruritic agent for the atopic dog.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.
authors.forename: D W
authors.initials: DW
authors.lastname: Scott
authors.forename: W H
authors.initials: WH
authors.lastname: Miller
authors.forename: S M
authors.initials: SM
authors.lastname: Cayatte
authors.forename: G A
authors.initials: GA
authors.lastname: Decker
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D006969:Hypersensitivity, Immediate / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D016593:Terfenadine / Q000008:administration & dosage* / Q000009:adverse effects; D017211:Treatment Failure
chemical_list: D016593:Terfenadine