title: [Ceftriaxone in prevention and treatment of experimental plague infection].
abstract: Ceftriaxone (rocefin), a 3rd generation cephalosporin with prolonged action, was highly efficient (ED50 0.12 to 0.38 mg/mouse) against experimental plague in albino mice infected either by Fra+ or Fra- strains of the plague microbe. The daily doses of the antibiotic (0.5-1.0-2.0 mg/mouse) provided 85-100 per cent survival of the animals. All the strains (15) of the plague microbe isolated from different natural foci and different objects were highly sensitive to ceftriaxone. The MIC was 0.02 to 0.05 microgram/ml.
authors.forename: I V
authors.initials: IV
authors.lastname: Ryzhko
authors.forename: E D
authors.initials: ED
authors.lastname: Samokhodkina
authors.forename: T A
authors.initials: TA
authors.lastname: Zhigalova
mesh_terms: D000818:Animals; D002443:Ceftriaxone / Q000627:therapeutic use*; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000517:prevention & control*; D015010:Yersinia pestis / Q000187:drug effects
chemical_list: D002443:Ceftriaxone
vernacular_title: Tseftriakson v profilaktike i lechenii éksperimental'noĭ chumy.