Influence of combined deficiency of fat and vitamin A on benzo(a)pyrene-induced lung carcinogenesis in rats.
The present study shows the effect of combined dietary deprivation of fat and vitamin A on benzo(a)pyrene (BaP) induced lung carcinogenesis in male Wistar rats. Lung tumors were induced by intratracheal instillation of BaP-Fe2O3 in normal saline. The tumor incidence and tumor burden in control animals were 82% and 2.28 respectively. Fat deficiency decreased the tumor incidence to 57% and tumor burden to 1.66. On the other hand, in vitamin A deficiency these were 83% and 4.02 respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor incidence and tumor burden to 69.6% and 2.7 respectively. The results suggest a protective role of low intake of fat in vitamin A deficiency for BaP-induced lung tumorigenesis in rats.
Khanduja
K L
KL
Department of Biophysics and Immunopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Koul
I B
IB
Sehgal
S
S
D000818:Animals; D001564:Benzo(a)pyrene; D004041:Dietary Fats / Q000008:administration & dosage*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000178:diet therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014802:Vitamin A Deficiency / Q000503:physiopathology*
D004041:Dietary Fats; D001564:Benzo(a)pyrene