title: Neurological crisis in hereditary tyrosinaemia and complete reversal after liver transplantation.
abstract: A 19 month old Indian girl with tyrosinaemia developed a severe generalised neuropathy involving both phrenic nerves. Treatment with haemarginate failed to improve her condition. After liver transplantation the raised concentrations of the neurotoxin delta amino-laevulinic acid returned to normal and gradual but complete neurological recovery occurred over a period of 13 months.
authors.affiliation: Department of Paediatrics, Addenbrooke's NHS Trust, Cambridge.
authors.forename: G
authors.initials: G
authors.lastname: Noble-Jamieson
authors.forename: N
authors.initials: N
authors.lastname: Jamieson
authors.forename: P
authors.initials: P
authors.lastname: Clayton
authors.forename: S
authors.initials: S
authors.lastname: Bailey
authors.forename: M
authors.initials: M
authors.lastname: Ryalls
authors.forename: N D
authors.initials: ND
authors.lastname: Barnes
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000628:therapy; D010791:Phrenic Nerve; D014443:Tyrosine / Q000097:blood*
chemical_list: D014443:Tyrosine