title: Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder.
abstract: Prolactin and cortisol responses to buspirone, a partial serotonin agonist with effects on the 5-HT1A receptor, were measured in 16 patients with DSM-III-R obsessive-compulsive disorder (OCD) and 16 normal controls. No consistent differences were observed between patients and controls with respect to the hormone responses measured. The results suggest that dysfunction of the 5-HT1A receptor is not present in OCD patients. The limitations of buspirone as a specific agonist challenge of the 5-HT1A receptor are discussed. Although data from other studies generally support a serotonin dysfunction in OCD, the question of which specific subtype(s) of receptor remains unanswered.
authors.affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia.
authors.forename: T R
authors.initials: TR
authors.lastname: Norman
authors.forename: M
authors.initials: M
authors.lastname: Apostolopoulos
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
authors.forename: F K
authors.initials: FK
authors.lastname: Judd
mesh_terms: D000328:Adult; D002065:Buspirone / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects
chemical_list: D011985:Receptors, Serotonin; D011388:Prolactin; D002065:Buspirone; D006854:Hydrocortisone