Clinical, serological and immunogenetic features of Japanese anti-Ro/SS-A-positive patients with annular erythema.
Sixteen anti-Ro/SS-A-positive patients with recurrent annular erythema, which has recently been recognized as a unique cutaneous manifestation of Sjögren's syndrome, were studied. Eight of the 16 patients met the American Rheumatism Association criteria for systemic lupus erythematosus. Fifteen patients had anti-La/SS-B antibodies. Antibodies against U1RNP were detected in 2 patients with systemic lupus erythematosus, 1 with anti-Sm antibodies. Patterns of autoimmune response to Ro/SS-A antigens were variable by immunoblot analysis. HLA typing by the standard complement-dependent microcytotoxicity assay revealed that all the 16 patients were positive for HLA-DRw52 antigens but negative for either HLA-B8 or HLA-DR3 which is reportedly associated with the autoimmune response to Ro/SS-A antigens in white and black patients.
Miyagawa
S
S
Department of Dermatology, Nara Medical University, Japan.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D044466:Asian People; D001323:Autoantibodies / Q000032:analysis; D015153:Blotting, Western; D004890:Erythema / Q000150:complications / Q000208:ethnology / Q000276:immunology* / Q000473:pathology; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007564:Japan; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications / Q000208:ethnology / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D017412:Ribonucleoprotein, U1 Small Nuclear; C035356:SS-A antibodies; C035357:SS-B antibodies