Hemispheric disconnection in Marchiafava-Bignami disease: clinical, neuropsychological and MRI findings.
We report a single-case study of a patient suffering from Marchiafava-Bignami disease (MBD), a rarely intra vitam diagnosed syndrome with focal demyelination in the corpus callosum, which is usually found in patients with chronic alcohol abuse. Our study explored a variety of motor, sensory and visual functions. Striking features were left apraxia caused by two lesions in the rostral area, and left hemidyslexia related to a large splenial lesion demonstrated by MRI. As symptoms of disconnection may remain undetected clinically, MRI is a most useful tool for the diagnosis of MBD.
Berek
K
K
Department of Neurology, University Hospital Innsbruck, Austria.
Wagner
M
M
Chemelli
A P
AP
Aichner
F
F
Benke
T
T
D000328:Adult; D000437:Alcoholism / Q000473:pathology / Q000503:physiopathology; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology* / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011932:Reading