A case of hepatocellular carcinoma consisting of two solitary poorly differentiated polyclonal intrahepatic tumor nodules.
Two intrahepatic solitary tumors consisting of poorly differentiated hepatocellular carcinoma (HCC) were identified as polyclonal HCC nodules by analysis of the pattern of integration of hepatitis B viral DNA into nuclear DNA. After the removal of each nodule by partial liver resection, recurrent multiple tumors appeared within 10 months postoperatively. The findings in this case suggest that the effectiveness of reduction surgery for intrahepatic multiple tumors is limited in solitary multicentric HCC that consists of poorly differentiated HCC.
Yamamoto
M
M
First Department of Surgery, Yamanashi Medical College, Japan.
Matsuda
M
M
Miura
K
K
Nagahori
K
K
Matsumoto
Y
Y
D015139:Blotting, Southern; D006528:Carcinoma, Hepatocellular / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*
D004273:DNA, Neoplasm; D004279:DNA, Viral