Decreased cerebral 5-HT1A receptors during ageing: reversal by Ginkgo biloba extract (EGb 761).
Investigation of [3H]8-hydroxy-2(di-n-propylamino)tetralin binding to 5-HT1A receptors in cerebral cortex membranes of Wistar rats showed that the maximal number of binding sites (Bmax) was reduced significantly (22%) in aged (24-month-old) as compared with young (4-month-old) animals. Chronic treatment with Ginkgo biloba extract did not alter binding in young rats but increased binding density significantly (33%) in aged rats. These results confirm previously described age-related 5-hydroxytryptaminergic alterations. Together with data in the literature, they also suggest a restorative effect in aged rats, associated with decreased receptor density resulting from the protective action of Ginkgo biloba extract treatment on neuronal membrane.
Huguet
F
F
Institut des Xénobiotiques, Faculté de Médecine et de Pharmacie, Poitiers, France.
Drieu
K
K
Piriou
A
A
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001667:Binding, Competitive; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D020441:Ginkgo biloba; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D000096983:Ginkgo Extract
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D010936:Plant Extracts; D011985:Receptors, Serotonin; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract