[The role of prostaglandins type E in tumor cells during their contact with NK-cells in vitro].
Active PGE--secretion by malignant tumour cells of Syrian hamsters was demonstrated 30 min after their contact with NK-cells in vitro. The duration of PGE--secretion depended upon the ratio of tumour cells and NK--cells, engaged in contact. Increase of the number of NK--cells (bound to tumour cells) up to 10:1-20:1 led to rapid release of PGE from majority of tumour cells; in this case PGE release was continued not longer than 1.5-2.0 hours. The active release of PGE can be stopped after the contact of tumour and NK--cells by indomethacin at any moment of its secretion.
Matveeva
V A
VA
Kliuchareva
T E
TE
Uvarova
E N
EN
D000818:Animals; D002450:Cell Communication; D002461:Cell Line, Transformed; D006224:Cricetinae; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000166:cytology*; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D015232:Dinoprostone; D007213:Indomethacin
Rol' prostaglandinov tipa E v opukholevykh kletkakh pri ikh kontakte s NK-kletkami in vitro.