[Three-factor correlation analysis of morphofunctional changes in mitochondria based on the results of morphologic and biochemical studies].
The multifactorial correlative analysis showed the tightness and correlative connection between the time after one time irradiation of experimental animals, breathing and redistribution of hepatocytes' mitochondria dimensions. It has been established that the velocity of mitochondrial breathing can be described by linear correlative dependences from time and area, negative coefficients in equations shows that the velocity of breathing decrease when time and mitochondrial area increase. This equations let to estimate mitochondrial population state, depending on time and their dimensions and show that big mitochondria perish in a more brief time. It was assumed that the velocity of destruction is depend on irradiation dose and it leads to the change of equation coefficients.
Sirotkin
V V
VV
Grishin
A Iu
AIu
Smirnov
V A
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D000818:Animals; D005163:Factor Analysis, Statistical; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008930:Mitochondria, Liver / Q000648:ultrastructure*; D015233:Models, Statistical; D010101:Oxygen Consumption / Q000502:physiology; D012044:Regression Analysis
Trekhfaktornyĭ korreliatsionnyĭ analiz morfofunktsional'nykh izmeneniĭ mitokhondriĭ po rezultatam morfologicheskogo i biokhimicheskogo issledovaniia.