[Corticosteroid therapy in cardiac sarcoidosis].
Corticosteroid treatment of cardiac sarcoidosis is not conclusive, although sarcoid granulomas in the heart may be more responsive to steroid therapy than in other organs. Healing of sarcoidosis lesions in the heart results in fibrosis and sinning of the myocardium, which may lead to aneurysm formation causing congestive heart failure or sudden death. Congestive heart failure is the leading cause of death in patients with cardiac sarcoidosis in Japan. It is reasonable to initiate steroid therapy as soon as the diagnosis of cardiac sarcoidosis is established in order to prevent fibrosis. Early initiation of steroid therapy with conventional treatment for specific cardiac manifestations (antiarrhythmic therapy, pacemaker implantation and heart failure medication) should bring improvement in the left ventricular systolic and diastolic function with prevention from malignant arrhythmias. Systemic disorder represents a contraindication to organ transplantation, but heart transplantation is now a feasible treatment for patients with end-stage cardiac sarcoidosis with congestive heart failure.
Ohmori
F
F
Department of Medicine, Osaka Prefecture Hospital.
Tachibana
T
T
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D009202:Cardiomyopathies / Q000188:drug therapy*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D012507:Sarcoidosis / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones