title: Intestinal permeability in patients with Crohn's disease and their first-degree relatives.
abstract: OBJECTIVE
  To measure small intestinal permeability in a group of patients with Crohn's disease in clinical remission and their apparently healthy first-degree relatives.
  
  
  METHODS
  Administration of 51Cr-labeled EDTA and subsequent measurement of its excretion in a 24-h urine collection.
  
  
  RESULTS
  Excretion of 51Cr-EDTA was not elevated in either the patients or in first-degree relatives.
  
  
  CONCLUSIONS
  Intestinal permeability to 51Cr-EDTA is not raised in patients with Crohn's disease in clinical remission or in their healthy first-degree relatives.
authors.affiliation: Stobhill General Hospital, Glasgow, Scotland, United Kingdom.
authors.forename: C W
authors.initials: CW
authors.lastname: Howden
authors.forename: I
authors.initials: I
authors.lastname: Gillanders
authors.forename: A J
authors.initials: AJ
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Duncan
authors.forename: B
authors.initials: B
authors.lastname: Danesh
authors.forename: R I
authors.initials: RI
authors.lastname: Russell
mesh_terms: D002860:Chromium Radioisotopes; D003424:Crohn Disease / Q000235:genetics / Q000503:physiopathology*; D004492:Edetic Acid; D006801:Humans; D007408:Intestinal Absorption / Q000235:genetics* / Q000502:physiology; D007421:Intestine, Small / Q000502:physiology*
chemical_list: D002860:Chromium Radioisotopes; D004492:Edetic Acid