[The effect of antigenic fractions of the outer membrane in Francisella tularensis on the functional activity of macrophages].
The influence of different gel-chromatographic antigenic fractions (GAF) of the membrane of F. tularensis, strain A'Cole, on different forms of reactivity of mouse peritoneal macrophages, such as the adhesion, ingestion and presentation of antigen on the cell surface, has been immunologically evaluated. GAF isolated from F. tularensis have been shown to produce a pronounced modulating effect on all forms of macrophagal functional activity under study. Thus, GAF II with a molecular weight of 85-200 kD inhibits the adhesion, ingestion and presentation of antigens and, on the contrary, GAF IV with a molecular weight of 15-35 kD stimulates these functions.
Skatov
D V
DV
Khlebnikov
V S
VS
Vasilenko
R N
RN
Kondakov
K E
KE
Galaktionov
V G
VG
D000276:Adjuvants, Immunologic; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification; D002448:Cell Adhesion / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D002478:Cells, Cultured; D002850:Chromatography, Gel; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D017737:Macrophages, Peritoneal / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D010587:Phagocytosis / Q000276:immunology; D014774:Virulence
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial
Vliianie antigennykh fraktsiĭ vneshneĭ membrany Francisella tularensis na funktsional'nuiu aktivnost' makrofagov.