[Treatment with clarithromycin of 173 HIV+ patients with disseminated Mycobacterium avium intracellulare infection].
No treatment was established for disseminated M. avium intracellulare (MAC) infection, a common disease of end stage of AIDS. An open study was conducted to assess in 173 AIDS patients, the activity of clarithromycin. Initial bacteriologic eradication from blood was observed in 136/147 evaluable patients (93%). Acquired resistance to clarithromycin associated with relapse appeared to develop after 2 to 7 months of drug treatment in 31/136 patients with initial success. Early bacteriological relapse was associated with clinical deterioration. Side effects of drug treatment were elevated liver enzymes (26%) and impaired hearing (4%). Side effects conducted to stop treatment in 14 cases (8%) to modified treatment in 8 cases (5%). Our study gave new argues for activity of clarithromycin in disseminated MAC infection.
Dautzenberg
B
B
Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Saint-Marc
T
T
Durant
J
J
Reynes
J
J
Meyohas
M C
MC
Legrand
M F
MF
Truffot
C
C
Chauvin
J P
JP
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D017291:Clarithromycin / Q000627:therapeutic use*; D002991:Clofazimine / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005260:Female; D024841:Fluoroquinolones; D006311:Hearing Disorders / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use; D015270:Mycobacterium avium-intracellulare Infection / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D012008:Recurrence; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D002991:Clofazimine; D008911:Minocycline; D017291:Clarithromycin
Traitement de 173 malades VIH+ atteints d'infection disséminée à M. avium intracellulare par une association incluant la clarithromycine.