title: Acute renal toxicity associated with suramin in the treatment of prostate cancer.
abstract: The use of suramin, a polysulfonated naphthylurea, in the treatment of advanced prostate cancer currently is being investigated. A 52-year-old man developed acute renal dysfunction after receiving nine doses of suramin. His suramin therapy was discontinued, but his serum creatinine level continued to rise to 10.8 mg/dl during the next 6 days. The patient was not rechallenged with suramin, and his renal function returned to baseline within the next 3 weeks. Future investigators of this drug should be aware of the possibility of such a reaction with parenteral administration.
authors.affiliation: Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: W D
authors.initials: WD
authors.lastname: Figg
authors.forename: M R
authors.initials: MR
authors.lastname: Cooper
authors.forename: A
authors.initials: A
authors.lastname: Thibault
authors.forename: D
authors.initials: D
authors.lastname: Headlee
authors.forename: J
authors.initials: J
authors.lastname: Humphrey
authors.forename: R C
authors.initials: RC
authors.lastname: Bergan
authors.forename: E
authors.initials: E
authors.lastname: Reed
authors.forename: O
authors.initials: O
authors.lastname: Sartor
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D003131:Combined Modality Therapy; D003404:Creatinine / Q000097:blood / Q000652:urine; D005485:Flutamide / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007668:Kidney / Q000187:drug effects*; D016729:Leuprolide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D013498:Suramin; D005485:Flutamide; D003404:Creatinine; D016729:Leuprolide; D006854:Hydrocortisone