Viral interactions with the host-cell cytoskeleton: the role of retroviral proteases.
A surprisingly large number of animal viruses interact with cytoskeletal elements inside infected cells at different stages of replication. For example, a viral protease is activated during assembly of murine leukemia viruses at the cell surface, which causes both the morphological conversion of 'immature' to 'mature' particles and a drastic reduction of the actin stress fiber network.
Luftig
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Dept of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112-1393.
Lupo
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LD
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D010450:Endopeptidases / Q000502:physiology*; D006678:HIV / Q000201:enzymology; D016333:HIV Protease / Q000502:physiology*; D006801:Humans; D009052:Leukemia Virus, Murine / Q000201:enzymology* / Q000502:physiology; D008954:Models, Biological; D014779:Virus Replication / Q000502:physiology
D010450:Endopeptidases; D016333:HIV Protease