Methotrexate in systemic lupus erythematosus.
OBJECTIVE
Methotrexate (MTX) has been used successfully in the treatment of rheumatoid arthritis, psoriatic arthritis, polymyositis, and Reiter's syndrome. Our objective was to determine the effectiveness of MTX in the treatment of systemic lupus erythematosus (SLE).


METHODS
We reviewed retrospectively MTX therapy in 5 patients with SLE, 3 with renal disease and 2 with arthritis.


RESULTS
MTX therapy was well tolerated and effective in all 5 patients.


CONCLUSIONS
MTX appears to be both effective and well tolerated in patients with SLE.
Walz LeBlanc
B A
BA
Lupus Clinic, Wellesley Hospital, Toronto, ON, Canada.
Dagenais
P
P
Urowitz
M B
MB
Gladman
D D
DD
D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D008181:Lupus Nephritis / Q000188:drug therapy / Q000209:etiology; D008727:Methotrexate / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D008727:Methotrexate