Thiol dependent oxidation of enzymes: the last chance against oxidative stress.
1. A survey of known effects of oxidized thiols on enzyme activity reveals a potential concerted action on metabolic pathways determining an impairment of anabolic reduction processes and an activation of the oxidative arm of the hexose monophosphate shunt. Thus it appears that, following oxidative stress, the increase of disulphides may act in restoring a reduced state in the cell by specifically channelling the metabolic energy flux.
Del Corso
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Dipartimento di Fisiologia e Biochimica, Università di Pisa, Italy.
Cappiello
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Mura
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D004220:Disulfides / Q000378:metabolism; D004734:Energy Metabolism; D004789:Enzyme Activation; D006600:Hexosephosphates / Q000378:metabolism; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D004220:Disulfides; D006600:Hexosephosphates; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D009249:NADP