[Analysis of parameters of the lipid peroxidation regulatory system in mouse organs at a later time after acute irradiation].
The antioxidant activity (AOA) and lipid fraction composition in organs from CBA and SHK mice were determined a month after acute irradiation with doses 4.5 and 5.0 Gy, correspondingly. More high radiosensitivity of these parameters in CBA mice in comparison with SHK mice was found. The decrease in antioxidant status of liver was shown. Pro-oxidant activity of spleen lipids was found. The direct correlation (r = 0.99 +/- 0.01) between survival and AOA of lipids for SHK mice was found. The changes in lipid fraction composition, more pronounced in spleen, were revealed. Thus, prolonged disturbance of lipid peroxidation regulatory system in two murine strains was established.
Shishkina
L N
LN
Poliakova
N V
NV
Taran
Iu P
IuP
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010545:Peroxides / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism*; D013997:Time Factors
D000975:Antioxidants; D010545:Peroxides
Analiz parametrov sistemy reguliatsii perikisnoga okisleniia lipidov v organakh mysheĭ v otdalennye sroki posle ostrogo oblucheniia.