Development of a novel drug delivery system, time-controlled explosion system (TES). IV. In vivo drug release behavior.
Time-Controlled Explosion System (TES) has the time-controlled drug release property with a pre-designed lag time. The drug release from the system is initiated by destruction of the membrane. In this study, metoprolol tartrate was used as a model drug. After five types of TES with different in vitro lag times were orally administrated to dogs, plasma metoprolol concentration was monitored. There existed a good correlation between in vitro and in vivo lag time, while the extent of absorbed metoprolol decreased with prolongation of lag time. Next, the in vivo drug release behavior was directly investigated using five different colored TES with a lag time of two hours. Each TES was consecutively administrated to the fasted dogs at predetermined intervals. The amount of metoprolol released was monitored by recovering the administered TES from the gastrointestinal trace. The in vivo release profile corresponded with the in vitro one. It is demonstrated that TES can release the drug in in vivo conditions similarly to in vitro. Based on these results, the decrease of the absorption is suggested to be caused by increased hepatic first-pass metabolism of the drug due to the retarded release rate with longer lag time.
Ueda
S
S
Pharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Company Ltd., Osaka, Japan.
Ibuki
R
R
Kawamura
A
A
Murata
S
S
Takahashi
T
T
Kimura
S
S
Hata
T
T
D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D004285:Dogs; D005079:Excipients; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism; D008297:Male; D008567:Membranes, Artificial; D008790:Metoprolol / Q000008:administration & dosage / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D005079:Excipients; D008567:Membranes, Artificial; D002482:Cellulose; C008079:hydroxypropylcellulose; D008790:Metoprolol