Gastric relaxation in response to chemical stimulation of the area postrema in the rabbit.
Microinjections of DL-homocysteic acid into the area postrema (AP) of anesthetized rabbits provoked gastric relaxations associated with small changes in blood pressure and marked excitatory effects on respiration. Both gastric and cardiovascular effects failed to occur after bilateral vagotomy. Comparable gastric relaxations were induced before and after treatment with atropine or atropine and guanethidine. The AP appears to play a role in gastric motility via vagus nerves and nonadrenergic noncholinergic intramural inhibitory neurons.
Bongianni
F
F
Dipartimento di Scienze Fisiologiche, Università di Firenze, Florence, Italy.
Mutolo
D
D
Srinivasan
M
M
Staderini
G
G
Baccari
M C
MC
Calamai
F
F
Pantaleo
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D006710:Homocysteine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation; D010791:Phrenic Nerve / Q000502:physiology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D013270:Stomach / Q000187:drug effects / Q000294:innervation*; D014628:Vagotomy
D006710:Homocysteine; C007956:homocysteic acid