Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria.
The effect of aging and treatment with acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria was studied. It was found that the activity of both these mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl-L-carnitine almost completely reversed this effect. Changes in the mitochondrial cardiolipin content appear to be responsible for these effects of acetyl-L-carnitine.
Paradies
G
G
Department of Biochemistry and Molecular Biology, University of Bari, Italy.
Ruggiero
F M
FM
Petrosillo
G
G
Gadaleta
M N
MN
Quagliariello
E
E
D000108:Acetylcarnitine / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000375:Aging; D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D051381:Rats; D013696:Temperature
D000244:Adenosine Diphosphate; D000108:Acetylcarnitine; D000226:Mitochondrial ADP, ATP Translocases; D003576:Electron Transport Complex IV