Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever.
Plasma penicillin levels were studied 2, 3, and 4 weeks after intramuscular benzathine penicillin G (BPG) doses of 1,200,000, 1,800,000, and 2,400,000 U. Proportions of patients with penicillin levels above 25 ng/ml at each week increased with increasing BPG dose. Further studies of higher-dose BPG for rheumatic fever prophylaxis are required.
Currie
B J
BJ
Menzies School of Health Research, Darwin, Northern Territory, Australia.
Burt
T
T
Kaplan
E L
EL
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010406:Penicillins / Q000097:blood*; D012213:Rheumatic Fever / Q000517:prevention & control*
D010406:Penicillins; D010401:Penicillin G Benzathine