Regulation of phosphatidylinositol:ceramide phosphoinositol transferase in Saccharomyces cerevisiae.
Maximal phosphatidylinositol:ceramide phosphoinositol transferase activity was measured in yeast cells harvested during the exponential phase of growth. The addition of inositol to the growth medium resulted in a twofold increase in IPC synthase activity in cells grown in the presence or absence of exogenous choline. Enzyme activity was not regulated in yeast inositol biosynthesis regulatory mutants by the addition of inositol to the growth medium.
Ko
J
J
Department of Food Science and Nutrition, University of Rhode Island, West Kingston 02892.
Cheah
S
S
Fischl
A S
AS
D002794:Choline / Q000378:metabolism; D006602:Hexosyltransferases / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000254:growth & development; D013107:Sphingolipids / Q000096:biosynthesis*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000378:metabolism*
D010716:Phosphatidylinositols; D013107:Sphingolipids; D007294:Inositol; D006602:Hexosyltransferases; C088714:phosphatidylinositol-ceramide phosphoinositol transferase; D017855:Transferases (Other Substituted Phosphate Groups); D002794:Choline