Extramammary Paget's disease of the axilla.
A case of extramammary Paget's disease of the axilla in an 84-year-old patient is presented. No underlying carcinoma was found and the lesion was treated successfully by wide local excision. Immunohistochemical staining showed nuclear immunoreactivity for c-myc and cytoplasmic staining for CEA, EMA, CAM 5.2, EGRF, c-erbB-2 and pan-cytokeratin in all the Paget cells. No immunoreactivity of the lesion was observed for S-100 protein, pan-ras, H-ras, K-ras, and p53 oncoproteins. Further research is needed to establish whether oncoprotein overexpression plays a role in the pathogenesis of extramammary Paget's disease and can be used as a diagnostic or prognostic marker.
Coppens
M
M
Department of Obstetrics and Gynaecology, University Hospital Antwerp, Edegem, Belgium.
Colpaert
C
C
Van Dam
P
P
Van Marck
E
E
Buytaert
P
P
D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000601:surgery