title: Competition for DNA steroid response elements as a possible mechanism for neuroendocrine integration.
abstract: For the analysis of a simple steroid-dependent mating behavior, careful response definition, complete neural circuit delineation and placement of estrogen-responsive cells within this circuit have been accomplished. Molecular studies of two relevant genes have emphasized DNA/RNA hybridization assays and DNA binding techniques. For both the rat preproenkephalin gene and the gene for the progesterone receptor, a strong induction by estrogen, tissue specificity of expression and a sex difference in regulation are prominent phenomena. On the rat preproenkephalin promoter, estrogen (ER) and thyroid receptors may compete for a DNA binding site. Likewise, progesterone (PR) and glucocorticoid receptors may compete for the same sites. On the rat PR gene, interactions between ER and AP-1 binding proteins are of special interest. Such interactions could underlay competitions and synergies between steroid hormones and neurally signalled events in the environment.
authors.affiliation: Rockefeller University, New York, NY 10021.
authors.forename: D W
authors.initials: DW
authors.lastname: Pfaff
authors.forename: M M
authors.initials: MM
authors.lastname: Freidin
authors.forename: X S
authors.initials: XS
authors.lastname: Wu-Peng
authors.forename: J
authors.initials: J
authors.lastname: Yin
authors.forename: Y S
authors.initials: YS
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001483:Base Sequence; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004745:Enkephalins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009490:Neurosecretory Systems / Q000378:metabolism*; D011374:Progesterone / Q000235:genetics; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics; D011987:Receptors, Steroid / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; D011987:Receptors, Steroid; D013256:Steroids; D011374:Progesterone; D004247:DNA; C033660:preproenkephalin