[The combined treatment of experimental genital herpes with preparations of interferon and acycloguanosine administered systemically and locally].
Combined treatment of experimental genital herpes with liposomal preparations of genetic-engineering alpha 2-interferon (reaferon) and acycloguanosine (acyclovir) was carried out in guinea pigs. The most effective therapeutic action of both preparations was achieved by their parenteral administration. Acyclovir proved to be more effective of the two. No statistically significant differences were observed upon parenteral administration of liposomal and nonliposomal forms of the preparations. The results of the experiments attest to the advantages of treatment of genital herpes by parenteral administration of reaferon and acycloguanosine.
Mel'nikov
V R
VR
Kobrinskiĭ
G D
GD
Lidak
M Iu
MIu
Barinskiĭ
I F
IF
D000212:Acyclovir / Q000008:administration & dosage*; D000818:Animals; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007370:Interferon Type I / Q000008:administration & dosage*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008081:Liposomes; D008297:Male; D011994:Recombinant Proteins
D004337:Drug Carriers; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008081:Liposomes; D011994:Recombinant Proteins; D000212:Acyclovir
Kombinirovannoe lechenie éksperimental'nogo genital'nogo gerpesa preparatami interferona i atsikloguanozina pri sistemnom i mestnom vvedenii preparatov.