Loss of heterozygosity in sporadic human breast carcinoma: a common region between 11q22 and 11q23.3.
The development of sporadic human breast cancer is associated with the accumulation of genetic alterations on several chromosomes. In the case of chromosome 11, loss of heterozygosity (LOH) at loci on the short arm has been well documented and suggests the presence of a suppressor gene(s) at 11p15.5. However, the evidence for similar events on the long arm is less compelling. Here, we determined the prevalence of LOH for chromosome 11q in 44 malignant and 3 benign cases of unselected sporadic breast tumor samples. We found that alteration of chromosome 11q is common in the pathogenesis of breast cancer as 19 of 44 (43%) malignant tumor specimens exhibited LOH. Eleven (58%) of these genetic alterations were specific to the long arm of the chromosome. The smallest region of shared LOH places the target between 11q22 and 11q23.3, the same general region frequently altered in cancers of the ovary, colon, skin, and uterine cervix, perhaps indicating the location of a tumor suppressor gene or genes of importance in each of these different tumor types.
Hampton
G M
GM
Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92318-5800.
Mannermaa
A
A
Winqvist
R
R
Alavaikko
M
M
Blanco
G
G
Taskinen
P J
PJ
Kiviniemi
H
H
Newsham
I
I
Cavenee
W K
WK
Evans
G A
GA
Winquist
R
R
D001943:Breast Neoplasms / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics; D018275:Carcinoma, Lobular / Q000235:genetics; D002291:Carcinoma, Papillary / Q000235:genetics; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005260:Female; D017353:Gene Deletion; D006801:Humans