Ototoxicity of carboplatin: comparing animal and clinical models at the Hospital for Sick Children.
Carboplatin was introduced to the paediatric population as an alternative chemotherapeutic agent in the management of various malignant neoplasms, including sarcomas of the head and neck, in the hope that it would have fewer side effects than pre-existing agents. While many investigators have considered the ototoxicity of this drug only incidentally, others have presumed it to be of negligible importance. A recent animal model of its use has demonstrated damage to the inner hair cells of the cochlea, particularly at the basal turn, with a corresponding high incidence of hearing loss. Similarly, 11 of 22 patients who received this agent at the Hospital for Sick Children over the past 2 years demonstrated a sensorineural hearing loss in the 4 to 12 kHz range. This complication occurred as early as after the first dose and was generally progressively worse with subsequent doses. Consequently, we recommend careful audiologic monitoring of children receiving this agent.
Macdonald
M R
MR
Department of Otolaryngology, Hospital for Sick Children, Toronto, Ontario.
Harrison
R V
RV
Wake
M
M
Bliss
B
B
Macdonald
R E
RE
D000293:Adolescent; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002682:Chinchilla; D003051:Cochlea / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects / Q000648:ultrastructure; D006309:Hearing / Q000187:drug effects*; D006311:Hearing Disorders / Q000139:chemically induced; D006316:Hearing Loss, High-Frequency / Q000139:chemically induced; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D011446:Prospective Studies
D016190:Carboplatin