Meige syndrome in the spectrum of Lewy body disease.
We report a patient with Meige syndrome (segmental cranial dystonia) who had neuropathologic changes of Parkinson's disease on postmortem examination. Neuropathologic examination showed typical and atypical Lewy bodies in the pigmented nuclei of the brainstem (substantia nigra, locus ceruleus), the nucleus basalis of Meynert, and the nucleus ambiguus. Neurochemical analysis of postmortem brain tissue showed evidence for decreased dopamine turnover in the substantia nigra, striatum, and nucleus accumbens. We propose that some cases of Meige syndrome may be included in the spectrum of Lewy body disease.
Mark
M H
MH
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Sage
J I
JI
Dickson
D W
DW
Heikkila
R E
RE
Manzino
L
L
Schwarz
K O
KO
Duvoisin
R C
RC
D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008538:Meige Syndrome / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology*
D001679:Biogenic Amines; D004298:Dopamine; D006719:Homovanillic Acid