Impaired gastric mucosal energy metabolism in congestive gastropathy in cirrhotic patients.
To clarify the characteristics of congestive gastropathy, we investigated gastric mucosal hemodynamics and energy metabolism in cirrhotic patients, using a reflectance spectrophotometry system and high performance liquid chromatography. The index of the gastric mucosal blood volume of cirrhotic patients with esophageal varices was significantly higher, and the index of gastric mucosal blood oxygenation significantly lower, than those in controls, thus indicating congestion and hypoxia in the gastric mucosa. Energy charge levels in the gastric mucosa of cirrhotic patients with esophageal varices were also significantly decreased. The energy charge level showed a strong linear correlation with the index of mucosal blood oxygenation in the antral (r = 0.996, P < 0.01) and body (r = 0.994, P < 0.01) mucosa of the stomach. These findings suggest that congestive gastropathy in a portal hypertensive state causes hypoxia in the gastric mucosa, leading to a mucosal energy deficit that may increase mucosal susceptibility to aggressive factors.
Kawano
S
S
First Department of Medicine, Osaka University School of Medicine, Suita, Japan.
Tanimura
H
H
Tsuji
S
S
Takei
Y
Y
Nagano
K
K
Kashiwagi
T
T
Fusamoto
H
H
Kamada
T
T
D002851:Chromatography, High Pressure Liquid; D004734:Energy Metabolism; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000503:physiopathology; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D013053:Spectrophotometry; D013272:Stomach Diseases / Q000209:etiology* / Q000503:physiopathology