[Stimulation of oxygen metabolism in human blood phagocytes as affected by tuftsin-like peptides derived from the C-reactive protein molecule].
Effects of synthetic peptides analogous to those cleaved by proteolysis from human C-reactive protein (CRP) molecule on the level of oxygen metabolism of blood neutrophils and monocytes were studied. The effects of the peptides were compared with the effect of tetrapeptide Thr-Lys-Pro-Arg (tuftsin). CRP-derived peptides stimulated phagocyte oxygen metabolism as effectively as tuftsin. Their effect did not depend on the presence of a second stimulus (E. Coli LPS) in the medium. Neutrophils and monocytes responded to CRP-derived peptides differently.
Polevshchikov
A V
AV
Nazarov
P G
PG
D000595:Amino Acid Sequence; D002097:C-Reactive Protein / Q000737:chemistry*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood*; D014405:Tuftsin / Q000737:chemistry / Q000494:pharmacology*
D008070:Lipopolysaccharides; D009842:Oligopeptides; D002097:C-Reactive Protein; D014405:Tuftsin; D010100:Oxygen
Usilenie kilsorodnogo metabolizma fagotsitov krovi cheloveka pod deĭstviem taftsinopodobnykh peptidov iz molekuly C-reaktivnogo belka.