The adverse effects of cholesterol in progressive glomerular injury.
Accumulating experimental evidence indicates that hypercholesterolemia is an aggravating factor in the progression of initial glomerular injury to glomerulosclerosis. Many features of progressive glomerular disease share biological properties with atherosclerosis and emerging data suggest a noxious role for oxidized low density lipoprotein in the glomerulosclerosis process. This article reviews these issues and examines the pathobiology of cholesterol-induced glomerular injury.
Diamond
J R
JR
Division of Nephrology, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
D000818:Animals; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D007674:Kidney Diseases / Q000209:etiology*; D012598:Sclerosis