[Mechanism of decoction of guizhi tang on dual-directional thermoregulation. Effect on the action of bombesin].
Hypothermia induced by administration of bombesin into the lateral ventricle of brain in cold exposed rats could be inhibited by Guizhi Tang (GZT). The GZT could also reverse the potency of fever induced by injection of [D-Phe12] bombesin, a bombesin receptor antagonist, into the brain of febrile rats. But there was no effect of GZT on body temperature when bombesin and [D-Phe12] bombesin were simultaneously injected into the lateral ventricle of cold exposed rats. These studies indicated that the dual-directional thermoregulation of GZT was carried out partially by affecting the bombesin receptor in thermoregulation center of hypothalamus.
Fu
H Y
HY
Institute of Chinese Materia Medica, China Academy of TCM, Beijing.
Zhou
A X
AX
Guo
S Y
SY
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001839:Bombesin / Q000037:antagonists & inhibitors*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005334:Fever / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018004:Receptors, Bombesin / Q000037:antagonists & inhibitors
D004365:Drugs, Chinese Herbal; D018004:Receptors, Bombesin; D001839:Bombesin