[Synthesis and interferon-inducing activity studies on the antiviral compounds of 2,5,6-trisubstituted-4(3H) pyrimidinone derivatives].
In order to search for more ideal antiviral drugs, 21 substituted pyrimidinone derivatives were designed and synthesized, among which 11 were not reported before. The chemical structures were characterized by elemental and spectral analysis. The serum interferon-inducing activity was tested in mice. All 2-amino-5-bromo-6-substituted-4-(3H)pyrimidinone compounds were shown to have interferon inducing activity. The corresponding substituted pyrimidine thiones were less active. The new compounds of 6-sulfophenyl derivatives are soluble in water, but the interferon-inducing activity are not higher than the original compound of ABPP.
Liu
X Y
XY
Department of Pharmacy, Shandong Medical University, Jinan.
Xu
L J
LJ
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007369:Interferon Inducers / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011897:Random Allocation
D000998:Antiviral Agents; D007369:Interferon Inducers; D011744:Pyrimidinones