[A comparative study of the antiarrhythmic action of bonnecor and the mesidide derivatives of alpha-azacycloalkane carboxylic acids].
The antiarrhythmic properties of the dibenzazepine derivative bonnecor and derivatives of mesidides of alpha-azacycloalkanocarboxylic acids were studied in various experimental arrhythmia models. The comparative study revealed different antiarrhythmic effects in different arrhythmia models. Bonnecor was found to have a higher antiarrhythmic activity in most arrhythmic models. Tertiary salts were demonstrated to be more potent than quaternary ones.
Paliani-Katsitadze
N Sh
NSh
Berdiaev
S Iu
SIu
Turilova
A I
AI
Kaverina
N V
NV
Likhosherstov
A M
AM
D000157:Aconitine; D000814:Aniline Compounds / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D002415:Cats; D003984:Dibenzazepines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008012:Lidocaine / Q000627:therapeutic use; D011342:Procainamide / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; D008012:Lidocaine; C048166:tiracizine; D011342:Procainamide; D000157:Aconitine
Sravnitel'noe izuchenie antiaritmicheskogo deĭstviia bonnekora i nekotorykh proizvodnykh mezididov al'fa-azatsikloalkankarbonovyykh kislot.