The neuronal regulation of fracture healing. Effects of sciatic nerve resection in rat tibia.
The effect of sciatic nerve resection on tibial fracture healing was studied in rats 25 days post-trauma. To prevent differences in loading between sham-operated and nerve-resected animals the fractured limbs were cast-immobilized. On radiograms 8 of 11 fractures in the sham-operated animals showed very little callus formation in contrast to only 1 of 8 fractures in the group with nerve resection. Measured by single-photon absorptiometry, animals with sciatic nerve resection had a higher bone mineral content than the sham-operated animals. However, the mechanical strength in three-point cantilever bending was not better in the nerve-resected rats, implying a defective organization of the large callus. These results suggest neural regulation plays a role in the type of fracture healing, primary or secondary, and in the amount and quality of the callus.
Nordsletten
L
L
Institute for Surgical Research, Rikshospitalet (The National Hospital), University of Oslo, Norway.
Madsen
J E
JE
Almaas
R
R
Rootwelt
T
T
Halse
J
J
Konttinen
Y T
YT
Hukkanen
M
M
Santavirta
S
S
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000502:physiology; D005593:Fracture Fixation, Internal; D017102:Fracture Healing / Q000502:physiology*; D008297:Male; D009929:Organ Size; D011859:Radiography; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000503:physiopathology* / Q000601:surgery; D013977:Tibia / Q000294:innervation / Q000473:pathology; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery