Seborrhoeic dermatitis: treatment with anti-mycotic agents.
In order to elucidate the effectiveness of anti-mycotics in treating seborrhoeic dermatitis, an attempt was made to isolate Malassezia from seborrhoeic lesions of patients of seborrhoeic dermatitis. The results revealed that, in male patients, 46/49 cases were positive for Malassezia furfur on the face and 30/48 cases were positive for M. furfur on the scalp. In female patients, 7/13 cases were positive for M. furfur on the face, and 6/17 cases were positive for M. furfur on the scalp. Anti-mycotic agents were excellent in 50% and good in 31% of the spore-positive cases, yielding an overall efficacy rate of 81%. In contrast, the treatment of the face with vehicle alone showed only one excellent result out of 8 cases. Although clinical improvement was rapid on the side treated with a topical corticosteroid in the half-side-test, numerous fungal elements remained. While the improvement with anti-mycotic agents was slower than that with the corticosteroid, clinical improvement became evident by the third week of administration and fungal elements disappeared.
Sei
Y
Y
Department of Dermatology, Showa University Fujigaoka Hospital, Yokohama, Japan.
Hamaguchi
T
T
Ninomiya
J
J
Nakabayashi
A
A
Takiuchi
I
I
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D012628:Dermatitis, Seborrheic / Q000188:drug therapy* / Q000382:microbiology; D003881:Dermatomycoses / Q000188:drug therapy; D005260:Female; D006801:Humans; D008290:Malassezia / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents