[Effect of peptide hydra morphogen on the structure of tissue components of rat myocardial layers in the early period of heart hypertrophy development].
The morphological study showed that the single injection of HMP (Hydra Morphogen Peptide) facilitated the development of the myocardium hypertrophy. This effect is expressed in the subendocardial layer most of all, where the normalization of the relative volume and diameter of the cardiomyocytes and the decrease of the connective tissue oedema are noted. These parameters are normalized in the intramural and subepicardial layers in less degree. The decrease of the connective tissue oedema is noted in the intramural layer. The normal correlation recovery between the relative volumes of the cardiomyocytes and the connective tissue is shown in the subepicardial layer, the diameters of the myocytes are essentially increased. The influence of HMP is manifested not only on the muscular and connective tissue components of the myocardium, but touches on also the system of the myocardial wall vessels, causing the redistribution of the intramural blood circulation.
Fedoseev
V A
VA
Kazimirskiĭ
A N
AN
Ionina
I A
IA
Lomakina
E B
EB
Rubina
A Iu
AIu
Pylaev
A S
AS
D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000473:pathology*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D009479:Neuropeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D009479:Neuropeptides; C032522:head activator peptide; D011761:Pyrrolidonecarboxylic Acid
Vliianie peptidnogo morfogena gidry na strukturu tkanevykh komponentov sloev miokarda krysy v rannie sroki razvitiia gipertrofii serdtsa.