[Dynamics of destructive and reparative processes in organs of the immune system in acute experimental peritonitis of varying course].
A quantitative characteristics of destructive and reparative processes in the organs of immune system is given on the model of acute peritonitis running under different conditions. During the usual course of inflammation in the abdominal cavity in the first 24 hours a sharp increase of lymphocyte destruction is noted, while proliferative changes decrease. Two days later the cell destruction decreases but proliferative changes increase. While using levamisole the destructive phenomena are not highly marked but proliferative processes persist at a high level during all periods of the experiment. In azathioprine immunosuppression the process of destruction increases intensively during all periods of the experiment with the simultaneous suppression of reparative manifestation. It results in devastation of the organs of the immune system and can be considered as an equivalent to the secondary immunological insufficiency.
Glumov
V Ia
VIa
Kir'ianov
N A
NA
Bazhenov
E L
EL
Ivanova
G S
GS
D000208:Acute Disease; D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D007107:Immune System / Q000503:physiopathology; D007978:Levamisole / Q000627:therapeutic use; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D010538:Peritonitis / Q000188:drug therapy / Q000276:immunology*; D051381:Rats; D012038:Regeneration / Q000502:physiology*
D007978:Levamisole; D001379:Azathioprine
Dinamika destruktivnykh i reparativnykh protsessov v organakh immunnoĭ sistemy pri ostrom éksperimental'nom peritonite v razlichnykh usloviiakh ego techeniia.