Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice.
Magnesium chloride (MgCl2.6H2O) was administered at dietary levels of 0 (control), 0.3, 0.6, 1.25, 2.5 or 5% to groups of 10 male and 10 female B6C3F1 mice for 13 weeks. In both sexes of the 5% treatment group a decrease in body weight was observed. While clinical signs and hematological or blood biochemistry parameters showed no treatment-related effects, histopathologically, vacuolation of kidney tubular cells was apparent in males of the 2.5 and 5% concentration groups. Thus, the study demonstrated that diet containing over 2.5% MgCl2.6H2O exerts toxic effects in B6C3F1 mice. We therefore conclude that a 2.5% level of MgCl2.6H2O in the diet is the minimal toxic dose.
Tanaka
H
H
First Department of Pathology, Nagoya City University Medical School, Japan.
Hagiwara
A
A
Kurata
Y
Y
Ogiso
T
T
Futakuchi
M
M
Ito
N
N
D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D015636:Magnesium Chloride / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D005503:Food Additives; D015636:Magnesium Chloride