[Hemostasis-regulating role of nicotinic acid and its analogs].
Nicotine acid and especially its analogs nicomorpholine and azethylnicotinate have ability to inhibit the thrombocytes' aggregation, inhibit thromboxane A2 biosynthesis, stimulate prostacyclin generative function of vascular wall, increase the cycle nucleotide level, have the features of calcium antagonists. This features predetermine their use for correction and healing of thromboembolic diseases and improvement of microcirculation, cerebral as well.
Akhundov
R A
RA
Tret'iak
V M
VM
Khalilova
E M
EM
Sadykhov
R V
RV
D000818:Animals; D002118:Calcium / Q000097:blood; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D011464:Epoprostenol / Q000096:biosynthesis*; D006487:Hemostasis / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D009539:Nicotinic Acids / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013928:Thromboxane A2 / Q000096:biosynthesis
D009539:Nicotinic Acids; D010975:Platelet Aggregation Inhibitors; D008315:Malondialdehyde; D013928:Thromboxane A2; D011464:Epoprostenol; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium
Gemostazreguliruiushchaia rol' nikotinovoĭ kisloty i ee analogov.