Expression of astroglial nerve growth factor in damaged brain.
This article provides an overview of different brain insults leading to induction of astroglial NGF expression. It discusses mechanisms of induction of astroglial NGF in a damaged brain and a possible role of its expression in pathophysiology of Alzheimer's disease. It emphasizes that the pharmacological manipulation of astroglial production of NGF may serve as a possible therapeutic strategy to ameliorate the pathological changes occurring after brain damage.
Oderfeld-Nowak
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Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Bacia
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D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D009414:Nerve Growth Factors / Q000096:biosynthesis*
D009414:Nerve Growth Factors