Severe hypotension associated with combined lithium and chlorpromazine therapy: a case report and a review.
The case of a patient who developed a severe hypotensive reaction with a persistent hemianaesthesia following the addition of lithium carbonate to her treatment regimen is described. The patient had been receiving chlorpromazine therapy for the management of hypomania and the addition of lithium carbonate to the chlorpromazine produced a severe hypotensive episode which compromised her neurological functioning. Only three doses of lithium carbonate had actually been taken by the patient. This type of hypotensive response associated with the simultaneous use of chlorpromazine and lithium has not previously been noted in the literature.
Byrne
A
A
University of Alberta, Edmonton.
Zibin
T
T
Chimich
W
W
Hnatko
G
G
D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D001794:Blood Pressure / Q000187:drug effects; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects
D016651:Lithium Carbonate; D002746:Chlorpromazine