[Na+ and K+ permeability of erythrocyte membranes and their phospholipid composition in hypertension patients].
The aim of investigation is to study and to compare simultaneously the data of erythrocyte membrane permeability (by Garay and Meyer method, 1979) with the number of the basic phospholipid (method of thin-layer chromatography) in the patients with essential hypertension (EH). 10 patients with EH and 8 healthy subjects (middle age 37 years) male were studied. The general phosphor and the following phospholipids of the erythrocyte membranes were studied: lysophosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, sphingomicin, phosphatidylcholine and phosphatide acids. The quantities were expressed in mkgP/10 erythr. Data comparisons gave us a possibility to establish that the reduction of the relation of flux rate Na+ and K+ in erythrocytes in the patients with EH (1.84 +/- 0.35) in comparison with healthy subjects (3.63 +/- 0.48) is correlated with the general phosphor (P < 0.01) and phospholipid fraction (P < 0.01) reduction.
Nadiradze
N I
NI
Grekulova
A N
AN
Kavtaradze
V G
VG
D000328:Adult; D001692:Biological Transport; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D012016:Reference Values; D012964:Sodium / Q000378:metabolism*
D008563:Membrane Lipids; D010743:Phospholipids; D012964:Sodium; D011188:Potassium
Pronitsaemost' membran éritrotsitov dlia Na+ i K+ i ikh fosfolipidnyĭ sostav u bol'nykh gipertonicheskoĭ bolezn'iu.