title: Effect of group substitution on the physicochemical properties of ibuprofen prodrugs.
abstract: A series of alkyl ester prodrugs of ibuprofen was synthesized and studied for its physicochemical properties like aqueous solubility, octanol-water partition coefficient and hydrolysis kinetics in aqueous buffer and human plasma. These physicochemical parameters have a forebearing on the overall activity profile of these prodrugs. Mathematical relationships have been derived to characterize these properties.
authors.affiliation: College of Pharmacy, Pushp Vihar, New Delhi, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Bansal
authors.forename: R K
authors.initials: RK
authors.lastname: Khar
authors.forename: R
authors.initials: R
authors.lastname: Dubey
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D006868:Hydrolysis; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs / Q000138:chemical synthesis*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011355:Prodrugs; D007052:Ibuprofen