Influence of Tołpa Peat Preparation on haemostasis in rats.
The influence of Tołpa Peat Preparation (TPP) on certain parameters of haemostasis was studied. The present results indicate that TPP (100, 200 and 300 mg/kg p.o.) had no influence on the bleeding time, clotting time, thrombin time, prothrombin time, kaolin-kephalin time, euglobulin lysis time, the concentration of fibrinogen, the platelet count and ADP-induced platelet aggregation. No changes in animals after long-term treatment with TPP (100 mg/kg for two weeks) were found either. In in vitro studies TPP given in concentrations 10(-5), 10(-4), 10(-3) and 10(-2) g/cm3 was used and certain changes of the studied parameters, probably caused by the presence of high salt content in this substance, were observed.
Buczko
W
W
Department of Pharmacodynamics, School of Medicine, Białystok, Poland.
Malinowska
B
B
Pietraszek
M H
MH
Pawlak
D
D
Chabielska
E
E
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001760:Bleeding Time; D002241:Carbohydrates / Q000494:pharmacology*; D004338:Drug Combinations; D006487:Hemostasis / Q000187:drug effects*; D006812:Humic Substances / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D012987:Soil; D013918:Thrombin Time; D014574:Uronic Acids / Q000494:pharmacology*
D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; D012987:Soil; C084029:Tolpa; D014574:Uronic Acids