title: Early effects of GM1 in experimental cerebral focal ischemia in rabbits.
abstract: This study aimed to investigate the effects of monosialoganglioside (GM1) when administered early in a model of cerebral focal ischemia, in the rabbit. The statistical evaluation of the electroencephalographic changes (quantified EEG analysis, QEEG) due to the ischemic event showed that the early treatment (1-3-24 h) with GM1 reduced the EEgraphic pattern typical of this model of cerebral ischemia. Considering the observation period, we hypothesized that it was due to the formation of an oedema of a lesser degree compared to the untreated group. Particularly, we did not obtain the increase in delta activity on the contralateral hemisphere, which we thought was expression of the diaschisi phenomenon.
authors.affiliation: Istituto Neurologico C. Mondino, Università di Pavia.
authors.forename: P
authors.initials: P
authors.lastname: Bo
authors.forename: E
authors.initials: E
authors.lastname: Marchioni
authors.forename: D
authors.initials: D
authors.lastname: Soragna
authors.forename: F
authors.initials: F
authors.lastname: Savoldi
mesh_terms: D000208:Acute Disease; D000818:Animals; D001929:Brain Edema / Q000517:prevention & control; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002462:Cell Membrane / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D005677:G(M1) Ganglioside / Q000494:pharmacology / Q000627:therapeutic use*; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy / Q000503:physiopathology; D008954:Models, Biological; D011817:Rabbits
chemical_list: D005677:G(M1) Ganglioside