title: Prevalence of mental illnesses in adult offspring of alcoholic mothers.
abstract: Recognition of maternal alcoholism as a risk factor for mental illness in adult offspring is important. Using the Diagnostic Interview Schedule (DIS), adult offspring of a clinical sample of alcoholic mothers were assessed for selected lifetime psychiatric disorders. Elevated adjusted odds ratio (OR) of alcohol abuse/dependence (OR 6.18, 95% confidence interval (CI) 2.0-19.02), and drug abuse/dependence (OR 3.75, 95% CI 1.13-12.34) were observed for daughters of alcoholic mothers compared with a group of women who reported no history of alcoholism in their parents. Prevalence rates of alcohol abuse/dependence, drug abuse/dependence, affective disorders, general anxiety disorder, panic disorder and schizophrenia were higher in sons of alcoholic mothers than in a male comparison sample who reported no history of parental alcoholism, however, these increases were not statistically significant.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: M
authors.initials: M
authors.lastname: Bidaut-Russell
authors.forename: S E
authors.initials: SE
authors.lastname: Bradford
authors.forename: E M
authors.initials: EM
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000453:epidemiology / Q000523:psychology* / Q000534:rehabilitation; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology*; D003430:Cross-Sectional Studies; D005220:Fathers / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D008875:Middle Aged; D008923:Missouri / Q000453:epidemiology; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D009035:Mothers / Q000523:psychology*; D016017:Odds Ratio; D010343:Patient Admission; D010552:Personality Assessment; D010553:Personality Development; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology; D012565:Schizophrenic Psychology; D012737:Sex Factors; D012931:Social Environment; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology