title: Homologies between different forms of 2-5A synthetases.
abstract: Sequence analyses of 2-5A synthetases of class I (M(r) 40,000-46,000) revealed high homology among them. The cDNA coding for the M(r) 69,000 2-5A synthetase of class II displayed in the second half a likewise high homology to the complete sequences of class I enzymes. This high degree of conservation of the 2-5A synthetases supports the assumption that these enzymes play important roles during virus infection (Williams et al. 1979; Coccia et al. 1990) and in the control of growth and differentiation of mammalian cells (Williams and Silverman 1985).
authors.affiliation: Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
authors.forename: E
authors.initials: E
authors.lastname: Truve
authors.forename: M
authors.initials: M
authors.lastname: Kelve
authors.forename: A
authors.initials: A
authors.lastname: Aaspollu
authors.forename: H C
authors.initials: HC
authors.lastname: Schröder
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D012330:RNA, Double-Stranded / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid
chemical_list: D012330:RNA, Double-Stranded; D015088:2',5'-Oligoadenylate Synthetase