Evaluating the loudness of phantom auditory perception (tinnitus) in rats.
Using our behavioral paradigm for evaluating tinnitus, the loudness of salicylate-induced tinnitus was evaluated in 144 rats by comparing their behavioral responses induced by different doses of salicylate to those induced by different intensities of a continuous reference tone mimicking tinnitus. Group differences in resistance to extinction were linearly related to salicylate dose and, at moderate intensities, to the reference tone as well. Comparison of regression equations for salicylate versus tone effects permitted estimation of the loudness of salicylate-induced tinnitus. These results extend the animal model of tinnitus and provide evidence that the loudness of phantom auditory perception is expressed through observable behavior, can be evaluated, and its changes detected.
Jastreboff
P J
PJ
Department of Surgery, University of Maryland, Baltimore.
Brennan
J F
JF
D000704:Analysis of Variance; D000818:Animals; D001307:Auditory Perception; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological; D008297:Male; D051381:Rats; D012044:Regression Analysis; D012459:Salicylates; D020156:Salicylic Acid; D013016:Sound; D014012:Tinnitus / Q000139:chemically induced / Q000503:physiopathology* / Q000523:psychology
D012459:Salicylates; D020156:Salicylic Acid