In vivo detection of myelin phospholipids in multiple sclerosis with phosphorus magnetic resonance spectroscopic imaging.
The goal of this study was to investigate myelin phospholipids in vivo in multiple sclerosis lesions and normal-appearing white matter by evaluating the spectral broad component from phosphorus 31 magnetic resonance spectroscopic imaging data. The phospholipid broad component was reduced nearly 35% (p < 0.001) in both lesions and in normal-appearing white matter in multiple sclerosis subjects compared to control subjects, suggesting reduced myelin phospholipid concentration or altered relaxation times.
Husted
C A
CA
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121.
Matson
G B
GB
Adams
D A
DA
Goodin
D S
DS
Weiner
M W
MW
D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D010758:Phosphorus
D010743:Phospholipids; D010758:Phosphorus