title: Phenotypic variation in hereditary breast cancer. Cancer control implications.
abstract: OBJECTIVE
  To study hereditary breast cancer pedigrees as models for the elucidation of the natural history of the disease, including early onset; bilaterality; and tumor associations in the heterogeneous variants to aid in its diagnosis and in targeting surveillance and treatment strategies.
  
  
  METHODS
  Oncology clinic and hereditary cancer institute.
  
  
  METHODS
  Physician- or self-referral probands.
  
  
  METHODS
  None.
  
  
  METHODS
  Greater understanding of the diagnosis, surveillance, and treatment of hereditary breast cancer.
  
  
  RESULTS
  Eighteen pedigrees displayed the phenotypic variation of breast cancer's natural history, obligate gene carriers, and patterns of tumor combinations consonant with genetic heterogeneity.
  
  
  CONCLUSIONS
  Hereditary breast cancer is an important public health problem accounting for about 9% of breast cancer cases. The recent identification of a molecular basis for the identification of a subset of hereditary breast cancer, and thereby the likelihood of the sequencing and cloning of the susceptibility gene(s), will enable targeting of surveillance and treatment measures toward patients at an inordinately high risk of developing cancer. Central to this entire process will be the identification of families with hereditary breast cancer.
authors.affiliation: Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Neb.
authors.forename: H T
authors.initials: HT
authors.lastname: Lynch
authors.forename: T A
authors.initials: TA
authors.lastname: Conway
authors.forename: J F
authors.initials: JF
authors.lastname: Lynch
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000235:genetics; D018268:Adrenocortical Carcinoma / Q000235:genetics; D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D013577:Syndrome