Evidence for different clinical subtypes of type 1 diabetes mellitus: a prospective study.
The purpose of this study was to determine whether the sex, age, severity of clinical presentation, presence of ICAs, IAs, and HLA-DR and DQ types could predict, in a cohort of newly-diagnosed diabetic children: (1) the duration of beta-cell function as measured by C-peptide response to a Sustacal meal; and (2) determine if those predictors could identify disease subtypes. A cohort of 170 consecutive patients was followed for 60 months after diagnosis. We found that age (0.0029), sex (0.0136), ICA (0.0001), presence of DKA (0.0070) and C-peptide peak at diagnosis (0.0000) significantly predicted the duration of residual beta-cell function over time. Furthermore, C-peptide secretion at diagnosis, presence of ICA, age and sex allowed the identification of three different prognostic groups with varying acceleration of beta-cell loss.
Schiffrin
A
A
Division of Endocrinology and Metabolism, Montreal Children's Hospital, Quebec, Canada.
Ciampi
A
A
Hendricks
L
L
Rozen
R
R
Weitzner
G
G
D000293:Adolescent; D000375:Aging / Q000378:metabolism / Q000502:physiology; D001323:Autoantibodies / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D012727:Sex Characteristics
D001323:Autoantibodies; D002096:C-Peptide; C024211:islet cell antibody