[Homeostasis, diabetes and cancer].
There is a large body of evidence to consider that the functional aspects of the metabolism of the cancer cell and hypoinsulinemic diabetes mellitus dwell at both ends of a biochemico-metabolic spectrum representing two opposite homeostatic and pathological tendencies. Furthermore, an initial homeostatic approach based up the acid-base balance and/or its hydrogen ion dynamics, systematically considered at multiple dimensions of knowledge and in different areas and fields of biomedical research, allows to reach a systematic vision and an all-comprehensive and hierarchically organized perspective for the integrated study of both malignant and non-malignant, as well as diabetic, metabolism, while at the same time opens new avenues reaching out towards a better understanding of both the etiopathogenesis of certain epithelial tumors and the chronic complications of diabetes mellitus. Besides, such a unitarian outlook may very well open new ways towards a more comprehensive understanding of the interrelationships among both degenerative processes, and from the bioenergetic to the clinical levels, hopefully leading to better preventive and treatment strategies.
Harguindey
S
S
Servicio de Oncología, Clínica la Esperanza, Vitoria, Alava.
D000471:Alkalosis / Q000209:etiology; D002471:Cell Transformation, Neoplastic; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism
D007328:Insulin
Homeostasis, diabetes y cáncer.