[Synthetic antioxidant correction for disorders of the regulatory and microcirculatory systems in the early stages of experimental atherosclerosis].
The influence of synthetic antioxidants (AOs) on hypothalamo-hypophyseal neuro-secretory system (HHNS), sympatho-adrenal system and microcirculatory bad in early stages of atherogenesis in rabbits (Anichkov's model) was studied. Correction of lipid metabolism and lipid peroxidation (LP) activation by AOs was accompanied by disappearing of structural changes in regulatory and microcirculatory systems, regression of atheromatosis in great arteries. Stabilization effect of AOs on neurons and erythrocytes membrane structures was noticed. Some distinctions in mechanism of action between mexidol and fenbutol were found. Thus, regulatory and microcirculatory disturbances, which appear on early atherogenesis stages and is the basis of chronic noninfectious pathology in different target-organs is reversible, for example trough LP correction.
Pozdniakov
O M
OM
Klimenko
E D
ED
Kobozeva
L P
LP
Michunskaia
A B
AB
Smirnov
L D
LD
D000311:Adrenal Glands / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D004036:Diet, Atherogenic; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009490:Neurosecretory Systems / Q000503:physiopathology; D010847:Picolines / Q000627:therapeutic use; D011341:Probucol / Q000031:analogs & derivatives / Q000627:therapeutic use; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013997:Time Factors
D000975:Antioxidants; D008074:Lipoproteins; D010847:Picolines; C085805:fenbutol; C070020:emoxypine succinate; D011341:Probucol
Korrektsiia sinteticheskimi antioksidantami narusheniĭ v reguliatornoĭ i mikrotsirkuliatornoĭ sistemakh na rannikh stadiiakh éksperimental'nogo ateroskleroza.