[Intra- and postoperatively metabolic intensive care by determination of the arterial blood ketone body ratio during hepatic surgery].
After establishing that the changes in the arterial blood ketone body ratio (AKBR) after glucose load were correlated with those in the mitochondrial redox state and hepatic energy charge (Redox theory), I found that when the redox state decreased, systemic organ failure of the brain, kidneys and heart as well as damage to the activities of the granulocytes, lymphocytes and thrombocytes occurred. This strongly points to the axial role of the mitochondrial redox state in the metabolism, host defense system and immune system of the living body. There have been many cases in which, thanks to early detection by AKBR, we were able to prevent potential complications from occurring. The serial measurement of AKBR is indispensable for the intra- and postoperative monitoring of graft liver function in liver transplantation and of the remnant liver function in hepatectomized patients with liver cancer.
Ozawa
K
K
Shiga University of Medical Science.
D003422:Critical Care; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D008107:Liver Diseases / Q000378:metabolism / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D016343:Monitoring, Intraoperative; D010084:Oxidation-Reduction
D007657:Ketone Bodies