[Progressive multifocal leukoencephalopathy and AIDS. Response to cytarabine].
PML affects 4% of patients with AIDS and there is no effective treatment. Five cases of PML-AIDS have been described, showing clinical and radiological improvement after treatment with C-ara. We describe the case of a 33-year-old woman, addict to heroin, her clinical record including VIH infection, pneumonia by P. carinii, milliary tuberculosis, infection by virus B and C and treatment with AZT and tuberculostatics since January, 1992. In May, she began to develop a cerebellar syndrome. Images obtained with nuclear magnetic resonance were typical of PML. Subsequently, treatment with C-ara (2 mg/kg/day IV during 5 days each 4-6 weeks) was begun. From the third month of treatment on, the patient showed a clinical improvement and as of the sixth month, the affected areas of white substance were reduced in size. In addition, CD4 improved. Although in this patient a positive effect was observed after treatment with C-area, it should be verified in a controlled clinical trial.
Hervas Laguna
M J
MJ
Servicio de Medicina Interna, Hospital Virgen de la Luz., Cuenca.
Nieto Rodríguez
J A
JA
Geijo Martínez
M P
MP
Ruiz Ribo
M D
MD
Borregón
S
S
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D003561:Cytarabine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy*
D003561:Cytarabine
Leucoencefalopatía multifocal progresiva y SIDA. Respuesta a la citarabina.