Dysplastic naevus: histological criteria and their inter-observer reproducibility.
Forty melanocytic lesions were examined in a pilot study, which was followed by a final series of 100 consecutive melanocytic lesions, in order to evaluate the inter-observer reproducibility of the histological criteria proposed for the dysplastic naevus. The specimens were examined in a blind fashion by four observers. Analysis by kappa statistics showed poor reproducibility of nuclear features, while reproducibility of architectural features was acceptable, improving in the final series. Consequently, we cannot apply the combined criteria of cytological and architectural features with any confidence in the diagnosis of dysplastic naevus, and, until further studies have documented that architectural criteria alone will suffice in the diagnosis of dysplastic naevus, we, as pathologists, shall avoid this term.
Hastrup
N
N
Department of Pathology, Amtssygehuset Roskilde, Denmark.
Clemmensen
O J
OJ
Spaun
E
E
Søndergaard
K
K
D001706:Biopsy; D003627:Data Interpretation, Statistical; D004416:Dysplastic Nevus Syndrome / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D009506:Nevus / Q000175:diagnosis / Q000473:pathology; D015588:Observer Variation; D010865:Pilot Projects; D015203:Reproducibility of Results; D012867:Skin / Q000473:pathology*