Effect of aging on urinary excretion of 18-hydroxycortisol.
The secretion of aldosterone declines with age. We reported that sodium depletion increased urinary excretion of 18-hydroxycortisol (18-OH-F). To elucidate the effect of aging on urinary excretion of 18-OH-F, we measured urinary 18-OH-F in 30 normotensive subjects aged 20-70 yr. There were significant negative correlations between age and urinary excretion of 18-OH-F or of aldosterone (r = -0.49, r = -0.58, P < 0.05, respectively) but not of urinary free cortisol. These results suggest that angiotensin may contribute to chronic regulation of 18-OH-F.
Takeda
Y
Y
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Miyamori
I
I
Yoneda
T
T
Iki
K
K
Hatakeyama
H
H
Takeda
R
R
D000328:Adult; D000368:Aged; D000375:Aging; D000450:Aldosterone / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D012044:Regression Analysis
D000450:Aldosterone; C033689:18-hydroxycortisol; D006854:Hydrocortisone