Predicting oliguria following indomethacin for treatment of patent ductus arteriosus.
Fifty-two consecutive infants who received intravenous indomethacin, 0.2 mg/kg, were reviewed to determine factors associated with the occurrence of oliguria. Serum creatinine and concentration prior to indomethacin did not predict the occurrence of oliguria. A mean urine output of less than 4.5 mL/kg/hr prior to the administration of indomethacin was the only factor that we determined to be associated with a significant risk of oliguria. Two infants developed symptomatic oliguria and both had a pre-indomethacin urine output less than 1.5 mL/kg/hr.
Barrington
K J
KJ
Department of Pediatrics, University of Alberta, Edmonton, Canada.
Fox
M
M
D003404:Creatinine / Q000097:blood; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D009846:Oliguria / Q000139:chemically induced*; D011379:Prognosis
D003404:Creatinine; D007213:Indomethacin