[Iatrogenic diffuse interstitial pneumonia linked to 5-aminosalicylate].
Iatrogenic pneumonias to sulphasalazine are most usually seen during the course of a haemorrhagic proctocolitis (RCH). We report a case in which a young woman was treated with 5-aminosalicylate (Pentasa) and prednisolone during an exacerbation of RCH. After 3 months of treatment the steroid therapy was stopped and the Pentasa was continued at the same dose (3 g per day). She presented with increasing dyspnoea on effort. Clinical examination was normal but a CT scan of the chest showed interstitial micro nodules; there was also a restrictive ventilatory disorder, hypoxaemia on effort and an alveolar eosinophilia (1.8%) The clinical progress, respiratory and blood gases all improved rapidly after stopping the Pentasa with the disappearance of the interstitial nodule over 5 months, suggesting that the role of the Pentasa was causal in the genesis of the pneumonia.
Declerck
D
D
Service de Pneumologie et d'Immunologie-allergologie, Hôpital A.-Calmette, Lille.
Wallaert
B
B
Demarcq-Delerue
G
G
Tonnel
A B
AB
D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003092:Colitis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D019804:Mesalamine; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011349:Proctitis / Q000188:drug therapy
D000636:Aminosalicylic Acids; D019804:Mesalamine; D011239:Prednisolone
Pneumopathie interstitielle diffuse iatrogène liée au 5-aminosalycilate.