Proposal for experimental studies to evaluate sodium hypochlorite dialysate in retroviral treatment.
Sodium hypochlorite (NaOCl) is widely used to inactivate retroviruses topically and on environmental surfaces. This proposal establishes the thesis that sodium hypochlorite and its related oxygen free radicals can be administered in minute quantities in vivo to achieve a reduction in retroviral titer within the infected individual. Published reports of animal studies and accidental sodium hypochlorite infusion in much greater concentrations have indicated that the protein depletion and oxidation of sulfhydryl compounds is reversible and possibly preventable by administration of disulfide reducing agents. Various methods of infusion can include the ex vivo retroviral inactivation of plasma utilizing extracorporeal circulation through a continuous centrifugal plasma separator. The utilization of infusion of low-concentration sodium hypochlorite dialysate for retroviral inactivation merits immediate experimental study. Chlorinated tap-water and table salt ingestion must also be among the environmental factors studied for correlation to HIV infection.
Avlicino
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AA
Newton
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CL
D000818:Animals; D004202:Disinfectants / Q000008:administration & dosage; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012192:Retroviridae Infections / Q000188:drug therapy*; D012973:Sodium Hypochlorite / Q000008:administration & dosage*
D004202:Disinfectants; D011506:Proteins; D017382:Reactive Oxygen Species; D012973:Sodium Hypochlorite