Acquired von Willebrand's disease following bone marrow transplantation.
A 41-year-old male underwent allogeneic bone marrow transplantation for the treatment of acute myelogenous leukemia. Six months later, he was admitted to a hospital with signs and symptoms consistent with worsening chronic graft-vs-host disease. Despite a negative past history for a bleeding diathesis, the patient was found to have absent factor VIII procoagulant and ristocetin cofactor activities with markedly reduced von Willebrand factor antigen, all consistent with a diagnosis of acquired von Willebrand's disease. Successful treatment of this disorder with aggressive apheresis and von Willebrand factor replacement therapy is noted.
Lazarchick
J
J
Department of Pathology/Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
Green
C
C
D000328:Adult; D001781:Blood Component Removal; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005169:Factor VIII / Q000032:analysis; D006086:Graft vs Host Disease; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D010314:Partial Thromboplastin Time; D012310:Ristocetin / Q000032:analysis; D014842:von Willebrand Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014841:von Willebrand Factor / Q000627:therapeutic use
D014841:von Willebrand Factor; D012310:Ristocetin; D005169:Factor VIII