Antifungal agents. VIII. Synthesis and antifungal activities of bipyrryl analogues of bifonazole.
Various bipyrryl analogues of bifonazole were synthesized starting from aryl-3-pyrryl-1-imidazolylmethanes. The introduction of a second pyrryl portion was performed by linking an acrylate moiety at 1-position of the pyrrole ring and then by treatment with TosMIC. The bipyrryl esters were hydrolyzed and decarboxylated to afford the required imidazoles. All new imidazole derivatives were tested against Candida albicans and Candida spp using as standard controls miconazole, bifonazole and ketoconazole.
di Santo
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R
Dipartimento di studi farmaceutici, Università di Roma, La Sapienza, Italy.
Massa
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S
Costi
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R
Simonetti
G
G
Retico
A
A
Apuzzo
G
G
Troccoli
F
F
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D006868:Hydrolysis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
D000935:Antifungal Agents; D007093:Imidazoles; D008697:Methane; C036596:bifonazole