Synthesis of 6 alpha-[18F]fluoroprogesterone: a first step towards a potential receptor-ligand for PET.
6 alpha-[18F]Fluoroprogesterone 3 was prepared by the BF3.Et2O-catalyzed reaction of progest-5 alpha, 6 alpha-epoxy-3,20-bisketal 1 and [18F]fluoride as a possible route for the in vivo visualization of progesterone receptors by PET. The radiochemical yield of 3 was 25% (EOB) and the sp. act. was 5 MBq/mumol (100 Ci/mol, EOS).
De Groot
T J
TJ
PET Center, University of Groningen, University Hospital, The Netherlands.
Braker
A H
AH
Elsinga
P H
PH
Visser
G M
GM
Vaalburg
W
W
D017666:Deuterium Oxide; D005459:Fluorides; D005462:Fluorine Radioisotopes; D006801:Humans; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D011980:Receptors, Progesterone / Q000032:analysis* / Q000378:metabolism; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D011980:Receptors, Progesterone; C088967:6-fluoroprogesterone; D011374:Progesterone; D017666:Deuterium Oxide; D005459:Fluorides