title: Primary central nervous system Burkitt's lymphoma presenting as Guillain-Barré syndrome.
abstract: A rare case of CNS Burkitt's lymphoma presenting as acute Guillain-Barré syndrome is presented. A 6-year-old previously healthy female presented with acute onset of limb and truncal weakness, involvement of ocular and bulbar nerves, and areflexia. The clinical diagnosis of Guillain-Barré syndrome prompted treatment with intravenous gammaglobulin with no response. A lumbar puncture following revealed marked pleocytosis, elevated protein, and decreased glucose. Immunological, cytological, and molecular studies of these cells confirmed the diagnosis of Burkitt's lymphoma IgM, kappa with t(8;14) and rearrangement of the J and kappa immunoglobulin chains. Aggressive systemic and intrathecal chemotherapy were started and within 5 days remission was achieved. The child is in complete remission 2 years from diagnosis. Although very rare, CNS lymphoma should be taken into account in every patient presenting with the clinical features of acute polyneuropathy.
authors.affiliation: Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Toren
authors.forename: M
authors.initials: M
authors.lastname: Mandel
authors.forename: E
authors.initials: E
authors.lastname: Shahar
authors.forename: E
authors.initials: E
authors.lastname: Rimmoni
authors.forename: H
authors.initials: H
authors.lastname: Roizin
authors.forename: Y
authors.initials: Y
authors.lastname: Neuman
authors.forename: F
authors.initials: F
authors.lastname: Brok-Simoni
authors.forename: Z
authors.initials: Z
authors.lastname: Mark
authors.forename: M
authors.initials: M
authors.lastname: Biniaminov
authors.forename: E
authors.initials: E
authors.lastname: Rosenthal
mesh_terms: D000208:Acute Disease; D002051:Burkitt Lymphoma / Q000175:diagnosis*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis*; D002648:Child; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D011129:Polyradiculoneuropathy / Q000175:diagnosis*