title: Protection against spinal cord ischaemia: one-shot infusion of hypothermic solution.
abstract: The protective effect of a one-short infusion of a range of low-temperature hypothermic solutions against spinal cord ischaemia was investigated. Forty rabbits were allocated into five groups each of eight animals. The abdominal aorta of each rabbit was clamped distal to the left renal artery, and also occluded for 30 min above the iliac bifurcation with an inflated 50-gauge French balloon catheter. Ringer's solution with lactate was infused through the catheter port distal to the balloon, at various temperatures (group I, uninfused control; group II, 33 degrees C; group III, 23 degrees C; group IV, 13 degrees C; and group V, 3 degrees C). The neurological status of the hind limbs was assessed on the second postoperative day using the criteria of Tarlov. A further eight rabbits underwent laminectomy at L2 or L3. Temperature probes were inserted into the spinal cord and the cord temperature monitored continuously during infusion in four rabbits from each of groups I and V. Spastic paraplegia occurred in five rabbits in group I, three in group II, and two in group III. Four rabbits in groups II and III, seven in group IV and all eight in group V showed complete recovery of neurological function. The infusion of 3 degrees C solution achieved significantly lower spinal cord temperatures in group V after aortic clamping, compared with the temperatures in group I (P < 0.001-0.005). It was concluded that protection against spinal cord ischaemia and prevention of postoperative paraplegia are promoted as the temperature of the hypothermic infusion solution is lowered.
authors.affiliation: Department of Surgery, Saga Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Hirahara
authors.forename: M
authors.initials: M
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Naitoh
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology / Q000601:surgery; D001794:Blood Pressure / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D002314:Cardioplegic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D002404:Catheterization; D003250:Constriction; D006614:Hindlimb; D007036:Hypothermia, Induced; D007260:Infusion Pumps; D007511:Ischemia / Q000517:prevention & control*; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D008638:Mesenteric Arteries; D009460:Neurologic Examination; D010264:Paraplegia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D011817:Rabbits; D012007:Rectum; D000077325:Ringer's Lactate; D013116:Spinal Cord / Q000098:blood supply* / Q000502:physiology
chemical_list: D002314:Cardioplegic Solutions; D007552:Isotonic Solutions; D000077325:Ringer's Lactate