title: [Epidemiology of congenital malformations at the Hospital Pedro García Clara, Ciudad Ojeda, Venezuela].
abstract: Results from an epidemiological study of congenital malformations (CM) realized at Pedro Garcia Clara Hospital from march 1989 to december 1992 are presented. Malformation was defined as all external or internal morphological defects that could be clinically diagnosed at birth. In all births, incidence and type of CM, birth condition, sex, weight, number of pregnancies and maternal ages were analyzed. Moreover, in live births from march 1989 to august 1991, were analyzed: the type of childbirth presentation, maternal residence place, paternal age, maternal and paternal occupation and school education, parental consaguinity, previous spontaneous abortions, other malformed in the family and exposition to physical agents, medicaments, vaccines, acute and chronical diseases and vaginal bleeding in the first trimester of pregnancy. The control group were children born during the same day and sex matched as the malformed children. The incidence of CM was 23.4 per 1000 total births. Most frequent malformations were principally minor or feasible of satisfactory treatment. Major malformations were Central Nervous System anomalies, specially, neural tube deffects and Down syndrome. Only maternal age, type of childbirth, other malformed members in the family and medicaments exposition were statistically significant. Our results confirm the importance and utility of CM epidemiology monitoring.
authors.affiliation: Unidad de Genética Médica, Facultad de Medicina, Univesidad del Zulia, Maracaibo, Venezuela.
authors.forename: L
authors.initials: L
authors.lastname: Pineda-Del Villar
authors.forename: M C
authors.initials: MC
authors.lastname: Martínez-Basalo
authors.forename: W
authors.initials: W
authors.lastname: Delgado
authors.forename: M
authors.initials: M
authors.lastname: Prieto-Carrasquero
authors.forename: Y
authors.initials: Y
authors.lastname: Villasmil
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000328:Adult; D000013:Congenital Abnormalities / Q000145:classification / Q000453:epidemiology*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D014687:Venezuela / Q000453:epidemiology
vernacular_title: Epidemiología de malformaciones congénitas en el Hospital Pedro García Clara. Ciudad Ojeda, Venezuela.