[Effects of monoclonal anti-idiotypic antibody, internal image of benzo(a)pyrene on sarcoma in rats].
The effects of a monoclonal anti-idiotypic antibody (Ab), internal image of conjugated benzo(a)pyrene [B(a)P], called AIB1, on B(a)P-induced malignant sarcomas in Sprague-Dawley (SD) female rats were evaluated at different times after B(a)P-administration. As previously described, circulating anti-"phosphatidylinositol (PtdIns)-like" autoantibody levels were found to be significantly higher in B(a)P-treated rat sera. They were decreased after AIB1 Ab-treatment. Furthermore, the tumor growth was slowed down compared with that of controls and animal survival was slightly increased. These results showed the relationships between metabolic pathways involving possible "B(a)P-like" endogenous ligand/cytosolic receptor(s) and the PtdIns.
Chagnaud
J L
JL
Laboratoire d'Immunologie et Pathologie, Université de Bordeaux II, Bordeaux, France.
Faiderbe
S
S
Geffard
M
M
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001564:Benzo(a)pyrene / Q000627:therapeutic use*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D012513:Sarcoma, Experimental / Q000188:drug therapy*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D001564:Benzo(a)pyrene
Effets d'un anticorps monoclonal anti-idiotypique, image interne du benzo(a)pyrène sur des sarcomes de rats.