title: Antineuronal antibodies in acute cerebellar ataxia following Epstein-Barr virus infection.
abstract: A 29-year-old man developed acute cerebellar ataxia following Epstein-Barr virus infection. Serum IgG and IgM antibodies reacted with both nuclear and cytoplasmic elements of neurons. Western blot revealed IgG binding to the 34- and 29-kd bands and IgM binding to the 44-, 37-, and 29-kd bands. The IgM reactivity gradually reduced. There was no identifiable neoplasm and the ataxia gradually improved. These findings suggest a role for autoimmune mechanisms in the pathogenesis of acute cerebellar ataxia.
authors.affiliation: Department of Neurology, Kitasato University East Hospital, Kitasato University, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Sayama
authors.forename: S
authors.initials: S
authors.lastname: Irie
authors.forename: N
authors.initials: N
authors.lastname: Kanazawa
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Kowa
authors.forename: S
authors.initials: S
authors.lastname: Haga
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D002524:Cerebellar Ataxia / Q000276:immunology* / Q000382:microbiology; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001323:Autoantibodies