Reversible activation of GABA and L-glutamate uptake into synaptosomes isolated from the rat brain in response to a single carbacholine injection into hippocampus.
In the present investigation the functional activity of transport systems mediating the GABA and L-glutamate uptake into nerve terminals of the rat brain cortex and hippocampus in response to a single carbacholine administration to hippocampus was studied. It has been established that synaptosomes isolated from the brain cortex and hippocampus of rats used in the experiments 24 h after a single carbacholine injection possess an increased capability of GABA and L-glutamate accumulation, and 48 h later the GABA and L-glutamate uptake begins to return to its control level and was equal to it on seventh day after injection.
Zharikova
A D
AD
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region.
Arkhipov
V I
VI
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D002217:Carbachol