Nuclear onco-protein targets of signal transduction pathways.
Irradiation of mammalian cells with ultraviolet light (200-400 nm) results in the activation of a number of genes, the so-called "UV response" (Herrlich et al., Rev. Physiol. Biochem. Pharmacol., 119:187-223, 1992). Many of the UV responsive genes are also transcriptionally activated by growth factors and mitogens. Two transcription factors have been demonstrated to acutely respond to these stimuli, namely AP-1 and NF-kappa B. Whereas NF-kappa B proteins are primarily controlled via proteolysis of regulatory domains which prevent nuclear translocation, the AP-1 proteins are regulated at several levels including transcription and posttranslational modification. Here, we discuss progress in the identification of the components of pathways acutely regulating these transcription factors.
Woodgett
J R
JR
Ontario Cancer Institute, Toronto, Canada.
Pulverer
B J
BJ
Plyte
S
S
Hughes
K
K
Nikolakaki
E
E
D000818:Animals; D002460:Cell Line; D006801:Humans; D008954:Models, Biological; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015533:Transcriptional Activation / Q000528:radiation effects; D014466:Ultraviolet Rays
D016755:Proto-Oncogene Proteins c-jun