title: Olfactory sensitivity in major depressive disorder and obsessive compulsive disorder.
abstract: Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of antidepressant drug therapy. No difference in olfactory sensitivity, to either odorant, was found between OCD patients and controls at any time. In MDD patients, a significant increase in the sensitivity to isoamyl acetate was observed 6 weeks after initiation of treatment, compared to controls.
authors.affiliation: Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Gross-Isseroff
authors.forename: K
authors.initials: K
authors.lastname: Luca-Haimovici
authors.forename: Y
authors.initials: Y
authors.lastname: Sasson
authors.forename: S
authors.initials: S
authors.lastname: Kindler
authors.forename: M
authors.initials: M
authors.lastname: Kotler
authors.forename: J
authors.initials: J
authors.lastname: Zohar
mesh_terms: D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology; D009833:Olfactory Pathways / Q000503:physiopathology; D012016:Reference Values; D012684:Sensory Thresholds / Q000502:physiology; D012903:Smell / Q000502:physiology*