[Remote effects in the mutagenic action of chrysotile asbestos and zeolite dusts in vivo].
It was proposed that there are a generalized mutagenic actions of chrysotile-asbestos fibers and zeolite particles in vivo. Chrysotile-asbestos fibers and different species zeolite particles in doses 50 mg/kg, intraperitoneally, increased the levels of damaged chromosomes not only in peritoneal cells, but also in bone marrow of C57BL/6 mice. Cytogenetic effect of chrysotile-asbestos does not depends on the time exposure of animals with mutagenic factor. In four weeks followed after administration chrysotile-asbestos fibers there were revealed 19-22% peritoneal cells with damaged chromosomes and 3.2-4.4% aberrant cells of bone marrow. Cytogenetic effect of zeolite particles was observed on 14-28 days after the administration, with peaks at 35.6% in peritoneal and 3.6-4.2% in bone marrow cells. Our data indicate the mutagenic action is realised as in cells contacted with dusts as in cells of other tissues. Probably, these effects are mediated by products of lipid peroxidation.
Durnev
A D
AD
Daugel'-Dauge
N O
NO
Korkina
L G
LG
Seredenin
S B
SB
Velichkovskiĭ
B T
BT
D000818:Animals; D017632:Asbestos, Serpentine / Q000633:toxicity*; D001202:Ascitic Fluid / Q000473:pathology*; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002869:Chromosome Aberrations; D004391:Dust; D005122:Exudates and Transudates; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*; D013997:Time Factors; D017641:Zeolites / Q000633:toxicity*
D017632:Asbestos, Serpentine; D004391:Dust; D009153:Mutagens; D017641:Zeolites
Distantsionnyĭ éffekt v mutagennom deĭstvii pyleĭ khrizotil-asbesta i tseolita in vivo.