title: Myeloproliferative disease in patients with a history of multiple blood donations: a report of 8 cases.
abstract: BACKGROUND
  The clonal origin of myeloproliferative disorders has been clearly demonstrated and it is known that reactive thrombocytosis occurs as a non specific response to various inflammatory or neoplastic conditions. Only a few papers have discussed the topic of myeloproliferative diseases in blood donors.
  
  
  METHODS
  We report 8 cases of myeloproliferative diseases (3 polycythemia vera and 5 essential thrombocythemia) in blood donors out of a total of 44 myeloproliferative disorders diagnosed in our Department during the last 5 years on the basis of the criteria established by the Polycythemia Vera Study Group criteria. As controls we considered 61 patients with reactive thrombocytosis referred to our Department in the same period of time. The estimated odds ratio was calculated according to standard methods.
  
  
  RESULTS
  The prevalence of blood donors with myeloproliferative disorders was 18.1%, while that of donors with reactive thrombocytosis was 3.2%. The estimated odds ratio was 6.56 with a 95% confidence interval between 1.07 and 17.3. No other single factor except blood donations was frequent in the past history of these patients.
  
  
  CONCLUSIONS
  Our data seem to indicate that both thrombocytosis and erythrocytosis resembled primary forms in these subjects; however, none of them suffered serious thrombotic and/or hemorrhagic symptoms. Our study indicates the importance of paying due attention to the blood cell counts of blood donors.
authors.affiliation: Institute of Medical Semeiotics, Padua Medical School, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Randi
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.forename: E
authors.initials: E
authors.lastname: Barbone
authors.forename: G
authors.initials: G
authors.lastname: Cavatton
authors.forename: F
authors.initials: F
authors.lastname: Fabris
authors.forename: A
authors.initials: A
authors.lastname: Girolami
mesh_terms: D000328:Adult; D001782:Blood Donors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence