title: Punctate porokeratotic keratoderma--its occurrence with internal neoplasia.
abstract: Punctate porokeratotic keratoderma (PPK) represents a diffuse involvement of palms and soles by multiple, accuminate keratotic papules and plugs, histologically identified by parakeratotic cornoid lamellae. A possible association between PPK and internal malignancy has been previously noted by Herman in 1973. A patient with a 3-month history of PPK is described in which a bronchial carcinoma was recently diagnosed. This association led us to speculate that PPK could be a sign of internal neoplasia, as already established for other forms of palmoplantar keratoderma. We suggest that the presence of an underlying malignancy must be screened for when a diagnosis of PPK is proposed.
authors.affiliation: Department of Dermatology, Tor Vergata University, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bianchi
authors.forename: A
authors.initials: A
authors.lastname: Orlandi
authors.forename: S
authors.initials: S
authors.lastname: Iraci
authors.forename: L G
authors.initials: LG
authors.lastname: Spagnoli
authors.forename: G
authors.initials: G
authors.lastname: Nini
mesh_terms: D001984:Bronchial Neoplasms / Q000150:complications* / Q000473:pathology; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017499:Porokeratosis / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology