Diagnosis of acute hepatitis E infection utilizing enzyme immunoassay.
Acute hepatitis E infection was diagnosed in a Pakistani immigrant admitted to the University of Illinois Hospital. Utilizing enzyme immunoassay (EIA) tests, specific IgG and IgM class antibodies to three different epitopes of hepatitis E virus (HEV) were detected 12 weeks after the onset of illness and in the early convalescent stage. Sixteen months after the onset of hepatitis, IgM anti-HEV was no longer detectable. Low levels of IgG class anti-HEV antibodies continued to be detected. We demonstrate the utility of the EIA HEV assay to diagnose prospectively acute HEV infection.
DeGuzman
L J
LJ
Section of Digestive and Liver Diseases, University of Illinois at Chicago.
Pitrak
D L
DL
Dawson
G J
GJ
Shin
D C
DC
Holzer
T J
TJ
Layden
T J
TJ
D000208:Acute Disease; D000328:Adult; D006508:Hepatitis Antibodies / Q000032:analysis*; D016751:Hepatitis E / Q000175:diagnosis* / Q000276:immunology; D016752:Hepatitis E virus / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male
D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M