Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine.
It is shown that ddA bis(SATE)phosphotriester is one of the most potent anti-HIV agents in cell culture. Compared with the parent nucleoside, ddA, an increase of 3 orders of magnitude was observed in the EC50, which makes this compound as active as AZT. This can be tentatively explained if one considers that direct ddAMP intracellular delivery shunts the well established ddA/ddI metabolism pathway.
Perigaud
C
C
Laboratoire de Chimie Bio-Organique, U.R.A. 488 du C.N.R.S., Université de Montpellier II, France.
Aubertin
A M
AM
Benzaria
S
S
Pelicano
H
H
Girardet
J L
JL
Maury
G
G
Gosselin
G
G
Kirn
A
A
Imbach
J L
JL
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D016048:Dideoxyadenosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D013601:T-Lymphocytes / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology*
D000998:Antiviral Agents; D015215:Zidovudine; D016048:Dideoxyadenosine