title: Clinical and histological features of 'mechanic's hands' in a patient with antibodies to Jo-1--a case report.
abstract: The clinical and histological features of 'mechanic's hands' are described in a patient with polymyositis characterized serologically by antibodies to histidyl tRNA synthetase (Jo-1). Although described in the past in association with polymyositis, these distinctive cutaneous lesions have only recently been associated with the 'anti-synthetase syndrome'. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clinical and serological features not only have prognostic significance, but also may provide insights into mechanisms of disease.
authors.affiliation: Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, UK.
authors.forename: D
authors.initials: D
authors.lastname: Mitra
authors.forename: C L
authors.initials: CL
authors.lastname: Lovell
authors.forename: T I
authors.initials: TI
authors.lastname: Macleod
authors.forename: R S
authors.initials: RS
authors.lastname: Tan
authors.forename: P J
authors.initials: PJ
authors.lastname: Maddison
mesh_terms: D000368:Aged; D000906:Antibodies / Q000032:analysis*; D005260:Female; D006229:Hand Dermatoses / Q000276:immunology / Q000473:pathology*; D006643:Histidine-tRNA Ligase / Q000276:immunology*; D006801:Humans; D007642:Keratosis / Q000276:immunology / Q000473:pathology; D017285:Polymyositis / Q000276:immunology / Q000473:pathology*
chemical_list: D000906:Antibodies; D006643:Histidine-tRNA Ligase