Homologies between different forms of 2-5A synthetases.
Sequence analyses of 2-5A synthetases of class I (M(r) 40,000-46,000) revealed high homology among them. The cDNA coding for the M(r) 69,000 2-5A synthetase of class II displayed in the second half a likewise high homology to the complete sequences of class I enzymes. This high degree of conservation of the 2-5A synthetases supports the assumption that these enzymes play important roles during virus infection (Williams et al. 1979; Coccia et al. 1990) and in the control of growth and differentiation of mammalian cells (Williams and Silverman 1985).
Truve
E
E
Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Kelve
M
M
Aaspollu
A
A
Schröder
H C
HC
Müller
W E
WE
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D012330:RNA, Double-Stranded / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid
D012330:RNA, Double-Stranded; D015088:2',5'-Oligoadenylate Synthetase