[Intrathyroidal lymphocytes in autoimmune thyroid diseases].
Aiming to assess the autoimmune origin of certain thyroid diseases, we studied the phenotypic composition and the ability of intrathyroidal lymphocytes to a re-induce HLA-DR expression on autologous thyrocytes coming from patients with graves's disease, nodular goiter and papillary thyroid carcinoma. Lymphocytes coming only from graves's disease patients were capable of reinduce HLA-DR expression on autologous thyrocytes (24.1 +/- 13.6 vs 1.5 +/- 2.54% in nodular goiter and carcinoma), as interferon gamma did (17.4 +/- 8.34%). Phenotypic characterization showed a significant decrease of T-CD3 (total lymphocytes) and T-CD4 (helper) in lymphocytes coming from patients with nodular goiter and carcinoma, and a marked reduction of T-CD8 (suppressor) in lymphocytes coming from patients with graves disease. Thus the T-CD4/T-CD8 ratio varies according to the etiology of the thyroidal disease. The lack of suppressor activity would explain why cells coming only from patients with graves disease, show marked HLA-DR expression. These findings give little support to the autoimmune origin hypothesis for nodular goiter and thyroid carcinoma.
Aguayo
J
J
Departamento de Medicina, Hospital Salvador, Universidad de Chile (Campus Oriente).
Wohlik
N
N
Baeza
A
A
Carrasco
A M
AM
Pineda
G
G
D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000276:immunology; D006044:Goiter, Nodular / Q000276:immunology; D006111:Graves Disease / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D013959:Thyroid Diseases / Q000276:immunology* / Q000473:pathology; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000276:immunology
D006684:HLA-DR Antigens
Linfocitos intratiroideos y enfermedad autoinmune del tiroides.