Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias.
Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity.
Webster
M T
MT
Department of Neurochemistry, Institute of Neurology, London, UK.
Francis
P T
PT
Procter
A W
AW
Stratmann
G C
GC
Doshi
R
R
Mann
D M
DM
Bowen
D M
DM
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000276:immunology / Q000378:metabolism*; D001329:Autolysis; D015153:Blotting, Western; D002540:Cerebral Cortex / Q000473:pathology; D003704:Dementia / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D014361:Trypsin Inhibitors / Q000276:immunology / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D014361:Trypsin Inhibitors