The effect of short-term alloxan-induced diabetes on the activity of drug metabolizing enzymes.
Chemical diabetes produced in male rats by treatment with alloxan (45 mg/kg) decreased aminopyrine N-demethylase activity but not hepatic microsomal protein, cytochrome P-450 and cytochrome b5 contents. In contrast, diabetes increased aniline hydroxylase activity. Glutathione S-transferase activity and the most of the forms of UDP-glucuronyltransferase were decreased but phenolsulphotransferase activity was not affected in alloxan-induced rats. These results suggest that observed changes may led to alteration of drug metabolism and toxicity in diabetes.
Pachecka
J
J
Department of Biochemistry and Clinical Chemistry, School of Medicine, Warsaw, Poland.
Kobylińska
K
K
Suchocka
Z
Z
Kuczyńska
J
J
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats
D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase