title: In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.
abstract: The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.
authors.affiliation: Laboratoire de Parasitologie, Institut de Médecine et d'Epidémiologie Africaines, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: L K
authors.initials: LK
authors.lastname: Basco
authors.forename: S
authors.initials: S
authors.lastname: Mitaku
authors.forename: A L
authors.initials: AL
authors.lastname: Skaltsounis
authors.forename: N
authors.initials: N
authors.lastname: Ravelomanantsoa
authors.forename: F
authors.initials: F
authors.lastname: Tillequin
authors.forename: M
authors.initials: M
authors.lastname: Koch
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
mesh_terms: D000166:Acridines / Q000302:isolation & purification / Q000494:pharmacology*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D015363:Quinolones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000166:Acridines; D000470:Alkaloids; D000962:Antimalarials; D015363:Quinolones; D002738:Chloroquine