Evidence that cell toxicity may contribute to the genotoxic response.
Comparisons of the structural determinants associated with genotoxic effects with those associated with cell or systemic toxicity indicate extensive overlaps. These findings can be taken to indicate that toxicity may contribute to genotoxicity.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
Zhang
Y P
YP
Klopman
G
G
D000818:Animals; D002468:Cell Physiological Phenomena; D002477:Cells / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D009152:Mutagenicity Tests; D051381:Rats; D013329:Structure-Activity Relationship; D014116:Toxicology / Q000379:methods*
D004247:DNA