title: Islet amyloid polypeptide in Psammomys obesus: lack of correlation between insulin resistance and plasma IAPP levels.
abstract: Sand rats (Psammomys obesus) develop insulin resistance and diabetes when given a standard laboratory diet. We have examined the presence of islet amyloid polypeptide (IAPP), or amylin, in these animals. IAPP is present in the beta-cells of pancreatic islets, its localization and intensity of immuno-reactivity are, thus, similar to that of insulin. In insulin resistant Psammomys obesus, insulin and IAPP immuno-reactivity in pancreas are markedly decreased, plasma insulin levels are 20-fold higher than in controls but IAPP levels are not different from those of normal animals. Therefore, insulin resistance in Psammomys obesus does not appear to result from an elevated plasma IAPP level nor from development of amyloid deposits.
authors.affiliation: Division of Metabolic Diseases, Institut de Recherches Servier, Suresnes, France.
authors.forename: J
authors.initials: J
authors.lastname: Duhault
authors.forename: M
authors.initials: M
authors.lastname: Boulanger
authors.forename: J
authors.initials: J
authors.lastname: Espinal
authors.forename: G
authors.initials: G
authors.lastname: Marquié
authors.forename: P
authors.initials: P
authors.lastname: Petkov
authors.forename: S
authors.initials: S
authors.lastname: Donev
authors.forename: R
authors.initials: R
authors.lastname: Jablenska
authors.forename: A
authors.initials: A
authors.lastname: Popov
mesh_terms: D000682:Amyloid / Q000097:blood*; D000818:Animals; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D005849:Gerbillinae; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000737:chemistry / Q000473:pathology*; D051381:Rats
chemical_list: D000682:Amyloid; D001786:Blood Glucose; D007328:Insulin; D058228:Islet Amyloid Polypeptide