title: Carbohydrate and lipid metabolism after 20 days of bed rest.
abstract: To test the hypothesis that physical inactivity affects carbohydrate and lipid metabolism, we studied the influence of 20 days bed rest in 14 young subjects (9 men and 5 women). There were no changes in body weight or estimated per cent body fat after 20 days bed rest. Total cholesterol, triglyceride, high density lipoprotein cholesterol, and apolipoprotein B levels did not change statistically during bed rest. But apolipoprotein AI levels were significantly lower during and immediately after bed rest compared with control values (p < 0.05). On the 3rd day of bed rest a decrease was found in high density lipoprotein-2 cholesterol (p < 0.05) and an increase in high density lipoprotein-3 cholesterol (p < 0.01) compared with control level. To evaluate the carbohydrate metabolism, each subject underwent a 75 g oral glucose tolerance test. The glucose concentrations in response to glucose ingestion did not change during bed rest, but insulin concentrations increased. The insulin-response curve to glucose ingestion tended to shift to the right during bed rest. From the 3rd day of bed rest an increase (p < 0.05) of total insulin and a decrease (p < 0.05) in blood glucose/insulin ratio were found during the glucose tolerance test which suggested a decrease in insulin sensitivity. These results suggested that physical inactivity impaired carbohydrate- and lipid metabolism.
authors.affiliation: Department of Health Administration, University of Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yanagibori
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: Y
authors.initials: Y
authors.lastname: Makita
authors.forename: A
authors.initials: A
authors.lastname: Gunji
mesh_terms: D000328:Adult; D001510:Bed Rest / Q000009:adverse effects*; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D050260:Carbohydrate Metabolism; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004435:Eating; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D012307:Risk Factors
chemical_list: D007328:Insulin; D008055:Lipids; D008074:Lipoproteins