Sustained-release dosage form of phenylpropanolamine hydrochloride. Part I: Microencapsulation and in vitro release kinetics.
Microcapsules of phenylpropanolamine hydrochloride with core:wall ratios of 1:1, 2:1 and 1:2 were prepared by the coacervation-phase separation method, using ethylcellulose as the coating material. Two batches of PPA.HCl powder with different particle sizes (> 58 microns and < 28 microns) were used as the core material. The different sizes of microcapsules were separated using a range of standard sieves (840-247 microns). The effects of drug particle size, the media pH and the core:wall ratio on the dissolution kinetics were studied, and evaluated kinetically.
Sevgi
F
F
University of Ege, Faculty of Pharmacy, Pharmaceutical Technology Department, Bornova, Izmir, Turkey.
Ozyazici
M
M
Güneri
T
T
D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005780:Gelatin; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010316:Particle Size; D010665:Phenylpropanolamine / Q000008:administration & dosage* / Q000737:chemistry*; D012995:Solubility
D002214:Capsules; D003692:Delayed-Action Preparations; D010665:Phenylpropanolamine; C013517:ethyl cellulose; D005780:Gelatin; D002482:Cellulose