title: [Change in cerebral beta-adrenoreceptors in experimental neurosis].
abstract: Pathological and adaptive-compensatory alterations of rat cerebral cortical beta-adrenergic receptors have been demonstrated using the model of experimental neurosis developing as a result of chronic emotional painful stress. After the first week of stress increases of both Kd and Bmax occur; both indexes reach control levels after 3 weeks of neurotization. The changes of cortical beta-adrenoreceptors accompany transient fall of cholesterol-to-phospholipid ratio and decrease of free radical lipid oxidation in brain cortex. The normalization of all cerebral parameters after 3 weeks of stress coincides with the activation of lipid peroxidation in blood serum.
authors.forename: M L
authors.initials: ML
authors.lastname: Libe
authors.forename: V I
authors.initials: VI
authors.lastname: Brusovanik
authors.forename: I P
authors.initials: IP
authors.lastname: Levshina
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D002908:Chronic Disease; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D009497:Neurotic Disorders / Q000209:etiology / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism
chemical_list: D005609:Free Radicals; D011943:Receptors, Adrenergic, beta
vernacular_title: Izmenenie sostoianiia beta-adrenoretseptorov golovnogo mozga pri éksperimental'nom nevroze.