title: Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment.
abstract: Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease were evaluated after oral administration of a single dose and after long-term treatment. A single oral dose of 1 mg colchicine led to a mean peak concentration of 3.60 +/- 1.04 ng/ml at a peak time of 2.16 +/- 0.34 h and a mean area under the plasma concentration time curve, extrapolated from time 0 to infinity, of 24.90 +/- 8.47 ng.h/ml. Comparable values were obtained after repeated administration. Distribution half-life was 2.83 +/- 0.74 h, and terminal plasma half-life was 9.81 +/- 2.08 h; the mean apparent volume of distribution and the mean apparent plasma clearance were 1448 +/- 4061 and 175.3 +/- 47.6 1/h, respectively. Colchicine concentrations in bile (2025 +/- 1368 ng/ml) were clearly higher than in plasma. Long-term treatment with colchicine (1 mg/day) in patients with various stages of primary biliary cirrhosis (PBC) was associated with colchicine concentrations varying from < 0.15 to 2.0 ng/ml, with a slight tendency to higher concentrations in PBC stages III-IV than I-II. Although about 20% of colchicine is excreted in bile within 24 h, accumulation of colchicine may appear only in patients with advanced liver disease and cholestasis.
authors.affiliation: Dept. of Medicine, University of Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Rudi
authors.forename: R
authors.initials: R
authors.lastname: Raedsch
authors.forename: C
authors.initials: C
authors.lastname: Gerteis
authors.forename: T
authors.initials: T
authors.lastname: Schlenker
authors.forename: J
authors.initials: J
authors.lastname: Plachky
authors.forename: I
authors.initials: I
authors.lastname: Walter-Sack
authors.forename: A
authors.initials: A
authors.lastname: Sabouraud
authors.forename: J M
authors.initials: JM
authors.lastname: Scherrmann
authors.forename: B
authors.initials: B
authors.lastname: Kommerell
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D002908:Chronic Disease; D003078:Colchicine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008134:Long-Term Care; D008875:Middle Aged
chemical_list: D003078:Colchicine