title: Pharmacokinetics and antiviral activity of a novel isonucleoside, BMS-181165, against simian varicella virus infection in African green monkeys.
abstract: A novel nucleoside analog BMS-181165 with potent activity against varicella-zoster virus was tested for efficacy in a simian varicella virus infection in African green monkeys. BMS-181165 was effective in preventing the development of a rash, decreasing the development of viremia and preventing death in infected monkeys when administered orally at 4, 16 or 64 mg/kg/day. The compound is well orally absorbed in monkeys, between 44 to 50% oral bioavailability, and may prove of value in therapy of varicella-zoster infections in humans.
authors.affiliation: Tulane Regional Primate Research Center, Covington, LA 70433.
authors.forename: K F
authors.initials: KF
authors.lastname: Soike
authors.forename: J L
authors.initials: JL
authors.lastname: Huang
authors.forename: J W
authors.initials: JW
authors.lastname: Russell
authors.forename: V J
authors.initials: VJ
authors.lastname: Whiterock
authors.forename: J E
authors.initials: JE
authors.lastname: Sundeen
authors.forename: L W
authors.initials: LW
authors.lastname: Stratton
authors.forename: J M
authors.initials: JM
authors.lastname: Clark
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D006566:Herpesviridae Infections / Q000150:complications / Q000517:prevention & control*; D006568:Herpesvirus 1, Cercopithecine; D016896:Treatment Outcome; D014529:Uridine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D014766:Viremia / Q000517:prevention & control
chemical_list: D000998:Antiviral Agents; C081111:BMS 181165; D014529:Uridine