Photoallergic contact dermatitis to oxybenzone.
A 21-year-old woman developed an erythematous papulovesicular eruption of photo-exposed sites, following the use of an oxybenzone-containing sunscreen. Patch testing, photopatch testing, phototesting, and histology produced findings strongly suggestive of oxybenzone photoallergy. Photopatch testing with a monochromator source showed abnormal UVA responses, with evidence of immediate urticaria, and delayed-onset dermatitis. Sun-barrier use is associated with a risk of the development of contact or photocontact allergic reactions. The benzophenones are frequently used in high-protection factor sun-barrier preparations, and appear to have a particular ability to induce such responses.
Collins
P
P
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, U.K.
Ferguson
J
J
D000328:Adult; D001577:Benzophenones / Q000009:adverse effects*; D017454:Dermatitis, Photoallergic / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D010328:Patch Tests; D012867:Skin / Q000473:pathology; D013473:Sunscreening Agents / Q000009:adverse effects*
D001577:Benzophenones; D013473:Sunscreening Agents; C005290:oxybenzone