[Change in systemic hemodynamics after acute administration of diazepam binding inhibitor (DBI) and after autoimmunization against DBI].
Endogenous peptide DBI inhibits the activity of HABA-ergic system and that is why can be a factor of arterial hypertension development. We investigated DBI influence on cardiac index (CI), arterial pressure (AP) and heart rate (HR) in rats. I.v. administration of DBI caused dose--dependent increase in CI, AP but HR did not change. High dose (150 mg/kg) caused a biphasic answer: hyperkinetic reaction reversed to cardiodepressive one. Long-term immunization against DBI led to decrease of AP and systemic vessel's resistance.
Ashmarin
I P
IP
Storozhevykh
T P
TP
Vakulina
O P
OP
Pinelis
V G
VG
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001794:Blood Pressure / Q000187:drug effects; D002352:Carrier Proteins / Q000276:immunology / Q000494:pharmacology*; D026261:Diazepam Binding Inhibitor; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007114:Immunization; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D001323:Autoantibodies; D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D005680:gamma-Aminobutyric Acid
Izmenenie sistemnoĭ gemodinamiki pri ostrom vvedenii ingibitora sviazyvaniia diazepama i pri autoimmunizatsii k nemu.