[Capacity of hypochlorite to penetrate into the lipid phase of human blood lipoproteins].
In order to elucidate the possibility of hypochlorite (NaOCl) presenting in aqueous media to penetrate into the surface proteolipid layer of low density lipoproteins (LDL), the kinetics of NaOCl-induced oxidation of spin probes localized within the lipid phase was studied. The paramagnetic analogs of stearic acid were employed as spin probes that contained doxyl groups localized at different positions on the carbon chain (at positions 5, 13 and 16). It was shown that all the three probes are oxidated by hypochlorite with the same rate both in aqueous media and in LDL. The results obtained indicate that hypochlorite in water may interact with groups in the lipid phase of LDL, including unsaturated--HC = CH--bonds.
Panasenko
O M
OM
Evgina
S A
SA
Sergienko
V I
VI
D004579:Electron Transport; D005609:Free Radicals; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D009589:Nitrogen Oxides; D010539:Permeability; D012973:Sodium Hypochlorite / Q000493:pharmacokinetics*; D013113:Spin Labels; D013229:Stearic Acids / Q000737:chemistry
D005609:Free Radicals; D008055:Lipids; D008077:Lipoproteins, LDL; D009589:Nitrogen Oxides; D013113:Spin Labels; D013229:Stearic Acids; D012973:Sodium Hypochlorite; C039900:nitroxyl
Izuchenie sposobnosti gipokhlorita pronikat' v lipidnuiu fazy lipoproteinov krovi cheloveka.