Morphofunctional changes in the noradrenergic innervation of the rat cardiovascular system after varying duration of noise stress.
One, six and twelve hs of exposure to acoustic stress showed different influences on the noradrenergic pattern and receptor function of the rat atria and aorta. Moreover, the lipid content of the adrenal cortex and hepatic glycogen were histochemically evaluated in the same animals to correlate these observations with the previous results. The increase in exposure time induced a corresponding increase in sympathetic innervation, which was more evident at cardiac level. The functional results showed that the potency of the agonists on the alpha- and beta-adrenoceptors does not vary, with the exception of 6-h treatment, which affected beta-receptors. By contrast, the M.R.R. of beta-receptors proved to be modified in all treatments, suggesting that noise stress affected mainly postreceptorial mechanisms linked to beta-adrenoceptors rather than their density or affinity; no significant functional modifications were observed when alpha-receptors were considered.
Breschi
M C
MC
Istituto Policattedra di Discipline Biologiche, Facoltà di Farmacia, Università di Pisa, Italy.
Scatizzi
R
R
Martinotti
E
E
Pellegrini
A
A
Soldani
P
P
Paparelli
A
A
D000302:Adrenal Cortex / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D002319:Cardiovascular System / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006651:Histocytochemistry; D050356:Lipid Metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009622:Noise / Q000009:adverse effects*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D013315:Stress, Psychological / Q000473:pathology* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000473:pathology* / Q000503:physiopathology
D008112:Liver Glycogen; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine