[Analysis of fibroblast growth factor receptor genes expressed in the retinal pigment epithelium of chick embryos by in situ hybridization].
To study the expression pattern of fibroblast growth factor receptor (FGFR) genes cek 1, cek 2, cek 3, and a novel FGFR (chick pigment epithelium derived FGFR, CPE-FGFR) in the retinal pigment epithelium (RPE) during chick eye development, in situ hybridization was performed on sections of chick embryos. cek 1 and CPE-FGFR were expressed, but neither cek 2 nor cek 3 were expressed in 3-day, 4-day, or 5.5-day chick embryonic RPE. Four subtypes of FGFR were expressed in 7-day and 9-day chick embryonic RPE. CPE-FGFR was expressed not only in RPE but also in whole embryos. The differential expression of FGFR subtypes in RPE at different stages suggests the possibility that FGFs influence the differentiation of RPE through the control of FGFR expression.
Fujiwara
M
M
Department of Ophthalmology, Okayama University Medical School, Japan.
D000818:Animals; D002642:Chick Embryo; D015870:Gene Expression; D017403:In Situ Hybridization; D010857:Pigment Epithelium of Eye / Q000196:embryology / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*
D017468:Receptors, Fibroblast Growth Factor