Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease.
The concentration of a product of lipid peroxidation (malondialdehyde) was determined in six areas of neocortex of 8 subjects with Alzheimer's disease and 8 control subjects. Malondialdehyde concentration was significantly increased by incubation with iron and ascorbate in all samples. Both basal and iron/ascorbate-stimulated malondialdehyde concentration were higher in the inferior temporal cortex of Alzheimer subjects than corresponding controls; other regions were unaffected. Basal concentrations of malondialdehyde correlated with age in both the inferior parietal lobule and the sensory/motor cortex.
Palmer
A M
AM
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213.
Burns
M A
MA
D000368:Aged; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009044:Motor Cortex / Q000378:metabolism; D009994:Osmolar Concentration; D010296:Parietal Lobe / Q000378:metabolism; D012016:Reference Values; D013003:Somatosensory Cortex / Q000378:metabolism; D013702:Temporal Lobe / Q000378:metabolism*; D014018:Tissue Distribution
D008054:Lipid Peroxides; D008315:Malondialdehyde