title: The diagnostic value of fine-needle aspiration biopsy under ultrasonography in nonfunctional thyroid nodules: a prospective study comparing cytologic and histologic findings.
abstract: Fine-needle aspiration biopsy (FNAB) of thyroid nodules has been proposed as a preoperative screening method to reduce the number of patients with benign nodules referred for surgery. Only a few previously published studies have compared cytologic results with a systematic surgical control; furthermore, the role of ultrasound guidance for FNAB in obtaining representative material has been poorly evaluated. The authors tried to assess the diagnostic value of FNAB performed under ultrasonography in a series of patients with a cold nodule and a systematic surgical control. This prospective study included 132 consecutive patients, 19 men and 113 women, aged from 18 to 82 years. The rate of carcinomas was 13.8%. A very high rate of adequate material was obtained (96.2%). Sensitivity, specificity, and global accuracy were 95%, 87.7%, and 89%, respectively. These results, which are equivalent to those previously published but associated with a low level of insufficient material, emphasize the diagnostic value of thyroid FNAB.
authors.affiliation: Service Central d'Anatomie et Cytologie Pathologiques, Hôpital Lariboisière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Cochand-Priollet
authors.forename: P J
authors.initials: PJ
authors.lastname: Guillausseau
authors.forename: S
authors.initials: S
authors.lastname: Chagnon
authors.forename: C
authors.initials: C
authors.lastname: Hoang
authors.forename: C
authors.initials: C
authors.lastname: Guillausseau-Scholer
authors.forename: P
authors.initials: P
authors.lastname: Chanson
authors.forename: H
authors.initials: H
authors.lastname: Dahan
authors.forename: A
authors.initials: A
authors.lastname: Warnet
authors.forename: P T
authors.initials: PT
authors.lastname: Tran Ba Huy
authors.forename: P
authors.initials: P
authors.lastname: Valleur
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography