[An analysis of the results of clinical trials of praziquantel analogs in intestinal cestode and trematode infections. 1. The treatment of intestinal cestode infections (diphyllobothriasis, taeniasis, hymenolepiasis)].
The studies have demonstrated a high efficacy of prasiquantel in therapy of enteric cestodiases. No differences in the efficacy and tolerance of prasiquantel analogs manufactured by various pharmaceutic firms (azinox, CIS; pikiton, China; biltricide, Bayer, India; cesol, Merk, India; cisticide, Merk India) were detected. Prasiquantel single dose (15 mg/kg) efficacies in diphyllobothriasis, taeniarhynchiasis, and taeniasis made up 91.4, 98.5, and 100%, respectively. In hymenolepiasis the efficacy of a total dose (40 and 50 mg/kg given twice with a 10-day interval) was 88.9%.
Bronshteĭn
A M
AM
Mel'nikova
L I
LI
Firsova
R A
RA
Legon'kov
Iu A
IuA
D000293:Adolescent; D000328:Adult; D000368:Aged; D004169:Diphyllobothriasis / Q000188:drug therapy* / Q000469:parasitology / Q000635:transmission; D005260:Female; D006801:Humans; D006925:Hymenolepiasis / Q000188:drug therapy* / Q000469:parasitology / Q000635:transmission; D008297:Male; D008875:Middle Aged; D010270:Parasite Egg Count; D011223:Praziquantel / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013622:Taeniasis / Q000188:drug therapy* / Q000469:parasitology / Q000635:transmission; D013997:Time Factors; D014201:Trematode Infections / Q000188:drug therapy* / Q000469:parasitology / Q000635:transmission
D011223:Praziquantel
Analiz rezul'tatov klinicheskikh ispytaniĭ analogov prazikvantelia pri kishechnykh tsestodozakh i trematodozakh. 1. Lechenie kishechnykh tsestodozov (difillobrotrioz, teniidozy, gimenolepidoz).