title: Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
abstract: The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.
authors.affiliation: Southern Research Institute, Birmingham, Alabama 35255-5305.
authors.forename: S
authors.initials: S
authors.lastname: Niwas
authors.forename: P
authors.initials: P
authors.lastname: Chand
authors.forename: V P
authors.initials: VP
authors.lastname: Pathak
authors.forename: J A
authors.initials: JA
authors.lastname: Montgomery
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D007042:Hypoxanthines / Q000737:chemistry / Q000494:pharmacology*; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*
chemical_list: D007042:Hypoxanthines; D011683:Purine-Nucleoside Phosphorylase