Effects on operant learning and brain acetylcholine esterase activity in rats following chronic inorganic arsenic intake.
1. Very young and adult Wistar rats were given As5+, 5 mg arsenic kg-1 body weight day-1 (sodium arsenate). 2. Operant learning was tested in a Skinner box at the end of exposure and, in the case of developing animals, also after a recovery period. 3. Acetylcholine esterase (AChE) activity was estimated in discrete brain regions of these animals. 4. The animals exposed to arsenic took longer to acquire the learned behaviour and to extinguish the operant. AChE activity was inhibited in some regions of the brain.
Nagaraja
T N
TN
Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
Desiraju
T
T
D000110:Acetylcholinesterase / Q000378:metabolism*; D000284:Administration, Oral; D000375:Aging / Q000378:metabolism; D000818:Animals; D001149:Arsenates / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003216:Conditioning, Operant / Q000187:drug effects*; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D001149:Arsenates; C009277:sodium arsenate; D000110:Acetylcholinesterase