The radionuclide assessment of pre-natally diagnosed hydronephrosis.
OBJECTIVE
To determine if a pre-operative non-invasive radionuclide study can predict the results of surgery in infants with pre-natally diagnosed hydronephrosis.


METHODS
Eight male infants with prenatally diagnosed hydronephrosis were treated by pyeloplasty within the first 4 months of life. All infants underwent a pre-operative diuresis renogram and a dimercapto-succinic acid (DMSA) scan, followed by a further renogram 6 months after surgery to assess renal function and drainage.


RESULTS
There was a significant difference between the results of the relative renal function estimates obtained by the pre-operative renogram and the pre-operative DMSA scan (P = 0.001). In all patients the recovery in renal function following surgery was accurately predicted by the pre-operative DMSA scan.


CONCLUSIONS
The results of this preliminary study suggest that a pre-operative DMSA scan could replace the use of invasive nephrostomy drainage to assess the potential for recovery in the poorly functioning neonatal kidney and give an indication of those kidneys most likely to benefit from reconstructive surgery.
Upsdell
S M
SM
Department of Urology, Royal Manchester Children's Hospital, Pendlebury, UK.
Gupta
S
S
Gough
D C
DC
D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D011184:Postoperative Period; D011296:Prenatal Diagnosis / Q000379:methods*; D011300:Preoperative Care; D011877:Radionuclide Imaging; D004113:Succimer
D004113:Succimer