title: Early genetic amniocentesis and its relationship to respiratory difficulties in paediatric patients: a report of findings in patients and matched controls 3-5 years post-procedure.
abstract: This study evaluates the long-term pulmonary complications of 25 children from a prospective, matched-control, pilot study evaluating short-term complications of early (11-14 weeks' gestation) versus traditional (15 weeks' gestation and later) genetic amniocentesis. Five children in the early amniocentesis group were found to have various respiratory difficulties, a morbidity rate comparable to that of paediatric patients in the general population. These data identify the need for larger, multicentre trials.
authors.affiliation: Department of Obstetrics and Gynecology, Keesler Medical Center, Biloxi, Mississippi.
authors.forename: B C
authors.initials: BC
authors.lastname: Calhoun
authors.forename: W
authors.initials: W
authors.lastname: Brehm
authors.forename: A T
authors.initials: AT
authors.lastname: Bombard
mesh_terms: D000649:Amniocentesis / Q000009:adverse effects*; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D010865:Pilot Projects; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D012016:Reference Values