title: [Antibiotic prophylaxis in a priori cesarean sections without a high risk of infection. Experiences of a Tunisian maternity department].
abstract: OBJECTIVE
  This study was conducted to evaluate the effect of antibiotic prophylaxy on decreasing the frequency of postoperative infections after cesarean sections performed in cases with no prior indication of a high risk of infection.
  
  
  METHODS
  A prospective randomized study included 269 cesarean sections without a high risk of infection performed in the Maternity and Neonatology Ward of the Sousse Hospital from February 1991 to July 1991. The patients were randomly divided into two groups. One group received an antibiotic prophylactic treatment including cephapirine, gentamicin and metronidazole) and the second group was given no treatment.
  
  
  RESULTS
  Antibiotic prophylactic therapy led to a reduction of infectious morbidity after cesarean section in patients without high risk o infection from 33% to 11%. A 66% rate of efficacy was observed. In addition, antibiotics given in this context led to substantial cost reduction both by reducing the cost of antibiotics prescribed in the postoperative period and by reducing the number of days of hospitalization, and thus total cost.
  
  
  CONCLUSIONS
  This study demonstrated the effectiveness of antibiotic prophylaxy for cesarean sections in patients without a high risk of infection. Nevertheless, a reevaluation of the antibiotic protocols and a rigorous operative procedure are essential.
authors.affiliation: Service de Gynéco-Obstétrique, Centre de Maternité et Néonatologie de Sousse, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Bibi
authors.forename: H
authors.initials: H
authors.lastname: Megdiche
authors.forename: H
authors.initials: H
authors.lastname: Ghanem
authors.forename: I
authors.initials: I
authors.lastname: Sfaxi
authors.forename: M
authors.initials: M
authors.lastname: Nouira
authors.forename: H
authors.initials: H
authors.lastname: Essaidi
authors.forename: A
authors.initials: A
authors.lastname: Chaieb
authors.forename: A
authors.initials: A
authors.lastname: Slama
authors.forename: H
authors.initials: H
authors.lastname: Khairi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use*; D002514:Cephapirin / Q000191:economics / Q000627:therapeutic use; D002585:Cesarean Section / Q000009:adverse effects*; D016527:Drug Costs; D004927:Escherichia coli Infections / Q000517:prevention & control; D005260:Female; D005839:Gentamicins / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008795:Metronidazole / Q000191:economics / Q000627:therapeutic use; D011247:Pregnancy; D011446:Prospective Studies; D011645:Puerperal Infection / Q000517:prevention & control*; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014416:Tunisia
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008795:Metronidazole; D002514:Cephapirin
vernacular_title: L'antibioprophylaxie dans les césariennes a priori sans "haut risque infectieux". Expérience d'une maternité tunisienne.