Dark adaptation in patients with Best vitelliform macular dystrophy.
Psychophysical dark adaptation studies were performed in six patients with Best vitelliform macular dystrophy (BVMD) using a Goldmann-Weekers dark adaptometer. Prebleach thresholds were determined before obtaining a postbleach full recovery curve. Unlike patients with Stargardt macular dystrophy, all patients with BVMD showed a normal time to reach their baseline dark adapted thresholds after bleaching of their rod visual pigment when tested in clinically normal appearing retina. Although a lipofuscin material accumulates within retinal pigment epithelial cells in patients with either Best or Stargardt dystrophy, functional findings pertaining to recovery of rod dark adaptation thresholds as well as electro-oculogram light peak to dark trough ratios are different in these two disorders.
Baca
W
W
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
Fishman
G A
GA
Alexander
K R
KR
Glenn
A M
AM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003623:Dark Adaptation / Q000502:physiology*; D005260:Female; D006801:Humans; D007700:Kinetics; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D011601:Psychophysics; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology; D017948:Retinal Rod Photoreceptor Cells / Q000503:physiopathology; D012684:Sensory Thresholds / Q000502:physiology