title: An autopsy case of light chain deposition disease.
abstract: This report describes a case of light chain deposition disease (LCDD) with unusual findings of fibrillar structures in the deposits and marked calcification in several organs. A forty-year-old man was initially diagnosed with LCDD in 1987, and died of sepsis three and one-half-years later. Histological examination of autopsy specimens demonstrated eosinophilic amorphous materials, which differed from amyloid, in vessel walls or around parenchymal cells in almost every organ examined. Ultrastructurally, in addition to granular deposits, fibrillar structures were also seen in the deposits. Marked calcification was present in the myocardium, skeletal muscles, adrenal glands and arteries.
authors.affiliation: Fourth Department of Internal Medicine, Saitama Medical School, Kawagoe.
authors.forename: N
authors.initials: N
authors.lastname: Kasahara
authors.forename: H
authors.initials: H
authors.lastname: Tamura
authors.forename: O
authors.initials: O
authors.lastname: Matsumura
authors.forename: R
authors.initials: R
authors.lastname: Nagasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Ohgida
authors.forename: S
authors.initials: S
authors.lastname: Itoyama
authors.forename: T
authors.initials: T
authors.lastname: Mitarai
authors.forename: K
authors.initials: K
authors.lastname: Isoda
mesh_terms: D000311:Adrenal Glands / Q000648:ultrastructure; D000328:Adult; D002114:Calcinosis; D006801:Humans; D007147:Immunoglobulin Light Chains; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure; D010265:Paraproteinemias / Q000473:pathology*; D013154:Spleen / Q000648:ultrastructure
chemical_list: D007147:Immunoglobulin Light Chains