Transforming growth factor beta 1-mediated growth inhibition in chick embryo fibroblasts: reversion by virally-expressed nuclear oncogenes.
Transforming growth factor beta 1 (TGF-beta 1) inhibits growth of primary cultures of chick embryo fibroblasts by affecting G1 and strongly increasing the generation time. This inhibition is reversed by the nuclear oncogenes v-jun, v-fos, v-myc, but not v-erbA and v-ets. It is also reversed by v-myb from either avian myeloblastosis virus or avian E26 retrovirus. Taken together, these results strongly suggest that independent, functional interferences may take place between the TGF-beta 1-induced growth inhibitory pathway and the oncogen-driven stimulatory pathway(s) at the level of the AP-1, Myc, and Myb transcription factors.
Piu
F
F
Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure, UMR 49, CNRS, 46, Lyon, France.
Jurdic
P
P
Brun
G
G
Samarut
J
J
Castellazzi
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002467:Cell Nucleus / Q000502:physiology; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology*; D016193:G1 Phase / Q000187:drug effects; D005814:Genes, Viral; D009857:Oncogenes; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D016212:Transforming Growth Factor beta