Efficacy of a resorbable hydrogel barrier, oxidized regenerated cellulose, and hyaluronic acid in the prevention of ovarian adhesions in a rabbit model.
OBJECTIVE
To compare the efficacy of a resorbable hydrogel material with oxidized regenerated cellulose and hyaluronic acid in an ovarian adhesion model.


METHODS
Controlled, blinded, and randomized study involving female rabbits.


METHODS
Academic research environment.


METHODS
A water-soluble hydrogen precursor was applied to the ovary as a liquid and converted to a hydrogel by exposure to long wavelength ultraviolet light, a 0.4% solution of hyaluronic acid was applied to the ovary, or an oxidized regenerated cellulose patch was applied to the ovary after wedge resectioning.


METHODS
Extent and severity of adhesion formation.


RESULTS
Application of the hydrogel reduced adhesion formation by 88%. Neither oxidized regenerated cellulose nor hyaluronic acid reduced adhesion formation.


CONCLUSIONS
The photopolymerized, resorbable hydrogel material is highly effective for the reduction of periovarian adhesions in this model.
Hill-West
J L
JL
Department of Biomedical Engineering, University of Texas, Austin 78712.
Chowdhury
S M
SM
Dunn
R C
RC
Hubbell
J A
JA
D000818:Animals; D002482:Cellulose / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010049:Ovarian Diseases / Q000473:pathology / Q000517:prevention & control*; D010053:Ovary / Q000473:pathology; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011817:Rabbits; D012038:Regeneration; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D002482:Cellulose; D006820:Hyaluronic Acid