Overview of clinical studies on artemisinin derivatives in Thailand.
Over 1000 patients have been treated with artesunate or artemether in clinical trials in Thailand since 1988. These drugs have proved rapidly effective and safe. Combination regimens with mefloquine have proved highly effective against multi-drug resistant Plasmodium falciparum infections. Both drugs are now licensed in Thailand.
Looareesuwan
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Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
D000962:Antimalarials / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins; D000077332:Artesunate; D002986:Clinical Trials as Topic; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000627:therapeutic use*; D013785:Thailand
D000962:Antimalarials; D000981:Antiprotozoal Agents; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C031327:artemisinin; D000077549:Artemether