title: Adductor laryngeal breathing dystonia in a patient with lubag (X-linked dystonia-Parkinsonism syndrome).
abstract: We report a patient with Lubag (X-linked dystonia-parkinsonism) who presented with severe respiratory stridor from adductor laryngeal breathing dystonia. Emergency tracheostomy was necessary, and subsequent laryngeal injection with botulinum toxin led to worsening aspiration. Botulinum toxin injection for severe lingual dystonia was successful.
authors.affiliation: Department of Neurology, University of Southern California, Los Angeles 90033.
authors.forename: M F
authors.initials: MF
authors.lastname: Lew
authors.forename: M
authors.initials: M
authors.lastname: Shindo
authors.forename: C B
authors.initials: CB
authors.lastname: Moskowitz
authors.forename: K C
authors.initials: KC
authors.lastname: Wilhelmsen
authors.forename: S
authors.initials: S
authors.lastname: Fahn
authors.forename: C H
authors.initials: CH
authors.lastname: Waters
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000009:adverse effects / Q000627:therapeutic use; D002230:Carbidopa / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004421:Dystonia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D004576:Electromyography / Q000187:drug effects; D005808:Genes, Recessive / Q000235:genetics*; D006801:Humans; D007273:Injections, Intramuscular; D007818:Laryngeal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012120:Respiration Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012135:Respiratory Sounds / Q000175:diagnosis / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa; D001905:Botulinum Toxins; D002230:Carbidopa