title: Cell kinetics and radiosensitivity of cervical squamous cell carcinoma.
abstract: Flow cytometry analyses of tumors from 12 patients with cervical squamous cell carcinoma under radiotherapy were performed in this preliminary study. Six patients with a high (> 10%) G2/M fraction before treatment showed greater than 50% tumor reduction after initial 2000 cGy radiotherapy. Only two out of six patients with a low (< 10%) G2/M fraction before treatment responded favorably and three of them already had recurrence during the follow-up period of 33-40 months. Hyperploidy (DNA index > 1.1) was observed in 5 patients; all of them responded well to radiotherapy in contrast to three out of seven diploid tumors.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University, College of Medicine, Taipei.
authors.forename: C A
authors.initials: CA
authors.lastname: Chen
authors.forename: C C
authors.initials: CC
authors.lastname: Wu
authors.forename: T M
authors.initials: TM
authors.lastname: Chen
authors.forename: L T
authors.initials: LT
authors.lastname: Lui
authors.forename: C F
authors.initials: CF
authors.lastname: Chang
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsieh
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy*; D005260:Female; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D008938:Mitosis; D008940:Mitotic Index; D011003:Ploidies; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy*