title: Bone marrow granulomas, fever, pancytopenia, and lupus-like syndrome due to tocainide.
abstract: We describe the case of a patient in whom a syndrome of fever, pancytopenia, pleural effusion, hepatosplenomegaly, positive ANA antibodies, and bone marrow granulomas developed in association with tocainide therapy. Tocainide, a recognized, albeit rare, cause of fever, lupus-like syndrome, and cytopenias, should be added to the list of medications that can cause bone marrow granulomas.
authors.affiliation: Department of Medical Education, Methodist Hospitals of Memphis, TN.
authors.forename: M S
authors.initials: MS
authors.lastname: Gelfand
authors.forename: F
authors.initials: F
authors.lastname: Yunus
authors.forename: F L
authors.initials: FL
authors.lastname: White
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D005334:Fever / Q000139:chemically induced*; D005500:Follow-Up Studies; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced*; D016677:Tocainide / Q000009:adverse effects*
chemical_list: D000974:Antibodies, Antinuclear; D016677:Tocainide