[Behavior disorders in rats exposed to intrauterine hypoxia, and their correction by postnatal treatment with piracetam].
Hypobaric hypoxia of the pregnant rats was followed by the reduction of weight gain of the newborn pups, delayed impairment of memory (passive and active tasks) and changes of extrapolative water escape. Piracetam (200 mg/kg/day) administered at early postnatal period (from 8th to 20th day of life) corrected behavioral disturbances and physical development in rats. Postnatal therapy by nootropics didn't influence in adaptive behavior damaged by prenatal hypoxia.
Trofimov
S S
SS
Ostrovskaia
R U
RU
Kravchenko
E V
EV
Smol'nikova
N M
NM
Bondarenko
N A
NA
Kutepova
O A
OA
Nemova
E P
EP
Voronina
T A
TA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications*; D007859:Learning Disabilities / Q000188:drug therapy* / Q000209:etiology; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology; D010889:Piracetam / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D010889:Piracetam
Narusheniia povedeniia krys, podvergshikhsia vnutriutrobnoĭ gipoksii, i ikh korrektsiia postnatal'nym vozdeĭstviem piratsetama.