title: A role for 17-beta-estradiol in immunoendocrine regulation of murine cysticercosis (Taenia crassiceps).
abstract: In experimental murine cysticercosis caused by Taenia crassiceps, parasite reproduction is favored by thymectomy or by orchidectomy, and restricted by ovariectomy. Hormonal reconstitution experiments showed that 17-beta-estradiol increases parasite numbers whereas 5-alpha-dihydrotestosterone was ineffective. Parasite numbers decreased with increments in cellular immunity but were insensitive to antibody levels. A possible immunoendocrinological interaction involving estrogen as a depressor of cellular immunity is envisaged in the control of cysticercosis.
authors.affiliation: Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F.
authors.forename: L I
authors.initials: LI
authors.lastname: Terrazas
authors.forename: R
authors.initials: R
authors.lastname: Bojalil
authors.forename: T
authors.initials: T
authors.lastname: Govezensky
authors.forename: C
authors.initials: C
authors.lastname: Larralde
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000276:immunology / Q000378:metabolism*; D003552:Cysticercus / Q000276:immunology*; D004958:Estradiol / Q000502:physiology*; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000502:physiology; D008297:Male; D051379:Mice; D009919:Orchiectomy; D010052:Ovariectomy; D013934:Thymectomy
chemical_list: D004958:Estradiol