title: The rate of the Down syndrome among offspring of women with Alzheimer disease.
abstract: It has been reported that the Down syndrome occurs more often than expected among relatives of individuals with Alzheimer disease. This study focused on 578 liveborn offspring of 206 females with Alzheimer disease. Controlling for maternal age at delivery, the frequency of the Down syndrome live births was as expected, based on data for the well-monitored general population of British Columbia (chi 2 = 5.39; df = 3; p > 0.05).
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Sadovnick
authors.forename: I M
authors.initials: IM
authors.lastname: Yee
authors.forename: C
authors.initials: C
authors.lastname: Hirst
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000544:Alzheimer Disease / Q000235:genetics*; D001955:British Columbia / Q000453:epidemiology; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged