title: [An evaluation of the protective activity of a multicomponent vaccine made from opportunistic microorganisms in the oral method of immunization in a model of local staphylococcal infection].
abstract: The protective activity of a multicomponent vaccine against S. aureus, prepared from Staphylococcus, Klebsiella, Proteus and Escherichia coli antigens, intended for oral administration, has been studied on the model of a local staphylococcal infection. The study has revealed that the vaccine, when administered orally to mice, prevents the development of gangrene in the paw, the death of the animals, and essentially decreases the local focus of infection. The optimum treatment schedule consists of five administrations of the preparation in doses of 2 mg.
authors.forename: V N
authors.initials: VN
authors.lastname: Efremov
authors.forename: V M
authors.initials: VM
authors.lastname: Poliachenko
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology*; D007114:Immunization; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D011514:Proteus vulgaris / Q000276:immunology*; D013203:Staphylococcal Infections / Q000401:mortality / Q000469:parasitology*; D013211:Staphylococcus aureus / Q000276:immunology*; D013997:Time Factors; D017778:Vaccines, Combined / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined
vernacular_title: Otsenka protektivnoĭ aktivnosti polikomponentnoĭ vaktsiny iz uslovno-patogennykh mikroorganizmov pri oral'nom metode immunizatsii na modeli lokal'noĭ stafilokokkovoĭ infektsii.