Expression of a 10.5 kDa inhibin in the endometrium of bonnet monkey on treatment with an antiprogestin ZK 98.299: an immunocytochemical study.
Immunocytochemical localization of inhibin was carried out in paraffin embedded tissue sections of the control and antiprogestin (ZK 98.299)-treated bonnet monkey endometrium using polyclonal antibodies generated against human seminal plasma inhibin (10.5 kDa). The study shows that administration of low doses (5 mg/week) of antiprogestin results in an increase in the expression of inhibin by the endometrium. Treatment with higher doses (20 mg/week) caused a decrease in the expression. Since treatment with higher doses also caused atropic changes in the endometrium, the decrease in inhibin could be the result of morphological damage to the endometrium rather than the effects of antiprogestin on the expression of inhibin. The potential involvement of endometrial inhibin in the process of nidation is speculated.
Ishwad
P C
PC
Institute for Research in Reproduction (ICMR), Parel, Bombay, India.
Garde
S V
SV
Sheth
A R
AR
Puri
C P
CP
D000818:Animals; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006067:Gonanes / Q000494:pharmacology*; D007150:Immunohistochemistry; D007265:Inhibins / Q000378:metabolism*; D007700:Kinetics; D008255:Macaca radiata; D008970:Molecular Weight; D011374:Progesterone / Q000037:antagonists & inhibitors*
D006067:Gonanes; D011374:Progesterone; D007265:Inhibins; C053238:onapristone