Synthesis, antiinflammatory and analgesic activities of some 1,2,4-thiadiazolidines and 1-4-aryl guanidines.
A series of 2,4-dimethyl-3,5-diarylimino-1,2,4-thiadiazolidines (1a-1) and 1-[2-(substituted benzothiazolyl]-1,3-dimethyl-4-aryl guanidines (2a-1) were evaluated for their anti-inflammatory and analgesic activities. Substitution of p-methoxy group (1c and 2c) in the aryl ring resulted in most active compounds in the series in both the activities and were also statistically equipotent than the standard drugs.
Naik
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PR
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, India.
Pandeya
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006146:Guanidines; D013844:Thiazoles