Molecular epidemiology of recent United Kingdom isolates of Neisseria meningitidis serogroup C.
The genomes of 34 recent United Kingdom isolates of Neisseria meningitidis serogroup C were examined by restriction enzyme digestion and by conventional and pulsed-field gel electrophoresis (PFGE). Strains were assigned to groups on the basis of the Dice similarity coefficient; strains with values of > 92% were considered to be clonally related. Twelve clones were identified by PFGE. Strains of two clonal groups predominated. Restriction endonuclease analyses using the 'high frequency cleavage' endonuclease Stu I and conventional electrophoresis gave 11 groups; in general it had lower resolving power than PFGE.
Yakubu
D E
DE
Department of Medical Microbiology, University of Aberdeen Medical School, Foresterhill.
Abadi
F J
FJ
Pennington
T H
TH
D004269:DNA, Bacterial / Q000032:analysis; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006801:Humans; D007621:Karyotyping; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics; D015183:Restriction Mapping; D012703:Serotyping; D006113:United Kingdom / Q000453:epidemiology
D004269:DNA, Bacterial