Trichothiodystrophic hair reveals an abnormal pattern of viscoelastic parameters.
Separate analysis and quantitative determination of the viscous and elastic parameters of hair performed in 5 patients with trichothiodystrophy and in 20 sex- and age-matched control subjects revealed an abnormal pattern of the mechanical behavior of trichothiodystrophic hair. The change of the viscous parameter is probably associated with the profound alterations in the high-sulfur proteins of the interfilamentary matrix; the changes in the elastic parameters may be related to the reduced stability of the irregularly arranged microfibrils of trichothiodystrophic hair caused by the marked reduction of the disulfide cross-links.
Tsambaos
D
D
Department of Dermatology, University of Patras, Greece.
Nikiforidis
G
G
Balas
C
C
Marinoni
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D003432:Cross-Linking Reagents; D004220:Disulfides / Q000378:metabolism; D004548:Elasticity; D005260:Female; D006197:Hair / Q000473:pathology* / Q000503:physiopathology; D006201:Hair Diseases / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D014783:Viscosity
D003432:Cross-Linking Reagents; D004220:Disulfides