Rheumatoid pericarditis: new immunopathological aspects.
Rheumatoid pericarditis (RP) is a well known extraarticular manifestation of rheumatoid arthritis (RA). It is not frequently diagnosed despite its high reported prevalence in post-mortem studies. There have been no immunohistological studies of its presence in pericardial membranes. Here we report a complete immunohistological study of two RA patients with RP complications, using a panel of monoclonal antibodies (mAbs) for the recognition of B, T, and NK cells. Both cases showed strong and almost exclusive pericardial membrane infiltration of CD8+ T-cells which was correlated with a higher than expected similar increase in the subset of peripheral blood lymphocytes (PBL). These findings suggest an important role for CD8+ T-cells in chronic RA, especially in this extraarticular manifestation of the disease.
Travaglio-Encinoza
A
A
INSERM U-291, Hôpital Gui de Chauliac, Montpellier, France.
Anaya
J M
JM
Dupuy D'Angeac
A D
AD
Rème
T
T
Sany
J
J
D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D016827:CD8 Antigens / Q000032:analysis; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010496:Pericardium / Q000276:immunology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal; D016827:CD8 Antigens