Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.
Niwas
S
S
Southern Research Institute, Birmingham, Alabama 35255-5305.
Chand
P
P
Pathak
V P
VP
Montgomery
J A
JA
D018360:Crystallography, X-Ray; D015195:Drug Design; D007042:Hypoxanthines / Q000737:chemistry / Q000494:pharmacology*; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*
D007042:Hypoxanthines; D011683:Purine-Nucleoside Phosphorylase