title: Interpersonal variables in the prediction of alcoholism among adoptees: evidence for gene-environment interactions.
abstract: The contributions of genetic and both positive and negative environmental factors were tested in the prediction of alcohol abuse/dependence among 300 adult adoptees. No direct effects for either genetic or environmental factors were significant in the prediction of adoptee alcohol abuse/dependence. However, among women, early-life family conflict and psychopathology in the adoptive family interacted with a biological background of alcoholism. Among women with at least one alcoholic biological parent, conflict or psychopathology in the adoptive family increased the probability of alcohol abuse and/or dependence. Among men, no significant interactions were found between a biological background of alcoholism and environmental variables. Results suggest a pattern of gene-environment interaction among women.
authors.affiliation: Department of Psychology, University of Iowa, Iowa City.
authors.forename: C E
authors.initials: CE
authors.lastname: Cutrona
authors.forename: R J
authors.initials: RJ
authors.lastname: Cadoret
authors.forename: J A
authors.initials: JA
authors.lastname: Suhr
authors.forename: C C
authors.initials: CC
authors.lastname: Richards
authors.forename: E
authors.initials: E
authors.lastname: Troughton
authors.forename: K
authors.initials: K
authors.lastname: Schutte
authors.forename: G
authors.initials: G
authors.lastname: Woodworth
mesh_terms: D000293:Adolescent; D000300:Adoption / Q000523:psychology*; D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology; D000987:Antisocial Personality Disorder / Q000235:genetics / Q000523:psychology; D001008:Anxiety Disorders / Q000235:genetics / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology; D003866:Depressive Disorder / Q000235:genetics / Q000523:psychology; D005260:Female; D005783:Gender Identity; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D012307:Risk Factors; D012931:Social Environment; D019966:Substance-Related Disorders / Q000235:genetics / Q000523:psychology