Linear IgA disease: cylindroma demonstrates heterogeneity of the target antigens.
Serum from 58 patients with linear IgA disease was tested by indirect immunofluorescence on the novel substrate cylindroma, which produces an abundance of basement membrane components. The use of split skin and of cylindroma has identified 2 target antigens. The majority of patients have a target antigen associated with epidermal cells and similar in distribution on cylindroma to hemidesmosome proteins. A minority have a dermal antigen with the distribution of collagen VII on cylindroma. These data support the hypothesis that linear IgA disease is a heterogeneous disease with regard to the target antigens.
Wojnarowska
F
F
Department of Dermatology, Churchill Hospital, Oxford, UK.
Allen
J
J
Collier
P
P
Whitehead
P
P
Leigh
I M
IM
D000236:Adenoma; D000941:Antigens / Q000032:analysis*; D001324:Autoantigens / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D002352:Carrier Proteins; D003094:Collagen / Q000032:analysis / Q000276:immunology; D003598:Cytoskeletal Proteins; D003896:Desmosomes / Q000276:immunology; D000071821:Dystonin; D006801:Humans; D007070:Immunoglobulin A; D007150:Immunohistochemistry; D016023:Integrins / Q000032:analysis / Q000276:immunology; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D012867:Skin / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*; D012878:Skin Neoplasms; D000097805:Collagen Type XVII
D000941:Antigens; D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007070:Immunoglobulin A; D016023:Integrins; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human; C044589:epidermolysis bullosa acquisita antigen