[Hypercholesterolemia: to treat or not to treat? That is the question].
Numerous epidemiological studies have confirmed the positive correlation of elevated serum cholesterol levels to increased coronary risk. Clinical and angiographical trials have shown that modification of hypercholesterolaemia by diet or drugs can lower cardiovascular morbidity and mortality. No good evidence exists that lowering serum cholesterol is harmful. In some meta-analyses enhancing statistical power, total mortality appears to be decreased in primary prevention trials if hypercholesterolaemia is sufficiently reduced. Current guidelines for cholesterol modification should include the primary prevention with identification of individuals at high risk, combined with population information, and the secondary prevention for the patients with symptomatic coronary heart disease.
Ducobu
J
J
Service de Médecine Interne, Hôpital de Tivoli, La Louvière.
D000367:Age Factors; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000209:etiology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000517:prevention & control / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011322:Primary Prevention; D012307:Risk Factors; D012737:Sex Factors
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D002784:Cholesterol
Hypercholestérolémie: traiter ou ne pas traiter? Telle est la question.