Transdermal estradiol. A potentially improved method of hormone replacement.
Estrogen replacement is usually administered as an oral preparation. Concerns have been expressed about the impact these oral preparations have on hepatic function. This paper reviews studies of one nonoral preparation that delivers estradiol into the systemic circulation by use of a transdermal system. Support for this delivery system for treating menopausal symptoms and, potentially, for avoiding side effects is presented.
Judd
H L
HL
Department of Obstetrics and Gynecology, University of California-Los Angeles School of Medicine 90024.
D000279:Administration, Cutaneous; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D017698:Postmenopause / Q000097:blood / Q000187:drug effects* / Q000502:physiology
D004958:Estradiol