Acyclovir excretion in human breast milk.
OBJECTIVE
To measure acyclovir concentrations in the breast milk of a lactating woman using the drug for herpes zoster while nursing her 7-month-old infant.


METHODS
The maternal dosage of acyclovir was 800 mg five times daily for seven days. Three random breast milk samples collected on the fifth and sixth days of therapy were analyzed for acyclovir concentrations with radioimmunoassay (RIA).


RESULTS
Acyclovir concentrations in breast milk ranged from 18.5 mumol (4.16 micrograms/mL) to 25.8 mumol (5.81 micrograms/mL). An estimate of the infant's dosage ingested through nursing was 0.73 mg/kg/d, or approximately 1 percent of the maternal dose in milligrams/kilograms/day. The baby was nursed without any signs of adverse effects.


CONCLUSIONS
Acyclovir was measured in clinically insignificant concentrations in the milk of a woman receiving large dosages for herpes zoster. Breast feeding continued without adverse effects to the nursing infant.
Taddio
A
A
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario.
Klein
J
J
Koren
G
G
D000212:Acyclovir / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D001942:Breast Feeding; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007223:Infant; D007774:Lactation; D008895:Milk, Human / Q000737:chemistry* / Q000378:metabolism; D011863:Radioimmunoassay
D000212:Acyclovir