Increased expression of mRNA for hepatocyte growth factor-like protein during liver regeneration and inflammation.
To assess potential roles of hepatocyte growth factor-like (HGFL) protein as a growth factor and as a cytokine, we determined the expression of mRNA for (HGFL) protein during liver regeneration and inflammation. Expression of mRNA for HGFL protein in the regenerating liver was upregulated to 93% and 64% above controls at 1 h following partial hepatectomy and carbon tetrachloride treatment of rats, respectively. Similarly, rat liver mRNA for HGFL protein was upregulated to 78% above controls at 24 h after injection of thioglycollate (inducing activation of peritoneal macrophages) and to 118% at 48 h after injection of turpentine (inducing the acute phase response). These results support a potential role for HGFL protein in the early phase of liver regeneration and as an inflammatory mediator.
Bezerra
J A
JA
Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, OH.
Laney
D W
DW
Degen
S J
SJ
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D015870:Gene Expression; D006133:Growth Substances / Q000096:biosynthesis*; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor; D017403:In Situ Hybridization; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D015345:Oligonucleotide Probes; D010957:Plasmids; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013864:Thioglycolates / Q000633:toxicity; D013997:Time Factors; D014425:Turpentine / Q000633:toxicity
D006133:Growth Substances; D015345:Oligonucleotide Probes; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D013864:Thioglycolates; C082332:macrophage stimulating protein; D017228:Hepatocyte Growth Factor; D002251:Carbon Tetrachloride; D014425:Turpentine