[Natural history of cardiac rhabdomyoma. Presentation of 2 cases with immunohistochemical study and review of the literature].
Two cases of cardiac rhabdomyoma have recently been observed in foetuses. The cardiac and muscular nature of the cells was confirmed by immunohistochemistry using monoclonal antibodies. A review of the literature shows that cardiac rhabdomyomas are usually considered to be hamartomas which are composed of primitive myocardial cells. Their spontaneous regression is often observed and apoptosis has been proposed as a possible mechanism of such a phenomenon. We propose that cardiac rhabdomyomas should be better considered as developmental vestiges rather than as true hamartomas. These vestigial structures would result either from a defect in differentiation, or from a defect in regression of primitive myocardial cells.
Medioni
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Laboratoire d'Anatomie et de Cytologie Pathologiques, Hôpital, Gui-de-Chauliac, Montpellier.
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Sarda
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D000032:Abortion, Therapeutic; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology*; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000473:pathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012207:Rhabdomyoma / Q000000981:diagnostic imaging / Q000473:pathology*; D016216:Ultrasonography, Prenatal
Histoire naturelle du rhabdomyome cardiaque. Présentation de deux observations avec étude immunohistochimique et revue de la littérature.