Famotidine has no effect on cardiac performance and liver blood flow in the rat.
Conflicting results have been reported on the effect of famotidine on cardiac performance and visceral hemodynamics, studied by non-invasive techniques. It is for that reason that we used the radioactive microsphere technique to study the effect of famotidine on cardiac performance in the rat. Hepatic blood flow (HBF) and portal blood flow (PBF) were measured during the same experiment. Rats were either given famotidine (2.0 mg/kg per day) or drinking water for 7 days through an orogastric tube. Administration of famotidine had no effect on cardiac output (CO), HBF, PBF, or liver blood flow (LBF), which is the sum of HBF and PBF. In both groups, LBF consisted of a similar fraction of CO, 14.5 +/- 3.9% and 15.7 +/- 4.38%, in the control and the famotidine groups, respectively. Pulse rate, systolic pressure and left ventricular contractility were not affected by famotidine. It is concluded that in the rat, administration of famotidine for 7 days has no effect on systemic, hepatic or portal hemodynamics.
Melzer
E
E
Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel.
Bardan
E
E
Krepel
Z
Z
Bar-Meir
S
S
D000818:Animals; D002248:Carbon Monoxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D015738:Famotidine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D015738:Famotidine; D002248:Carbon Monoxide