Allele loss on chromosome 17 in ovarian cystic teratomas.
We examined the DNA from 12 patients with ovarian tumors (four benign germ cell tumors, one malignant germ cell tumor, one benign common epithelial tumor and six common epithelial carcinomas) for the allele loss on chromosome 17 using 12 probes for hypervariable loci. At THH59 loss of heterozygosity (LOH) was detected in three benign germ cell tumors and two epithelial carcinomas. At a more distal locus, KKA35, LOH was detected in three benign germ cell tumors and one epithelial carcinoma.
Kido
M
M
Department of Genetics, University of Tokyo.
Ito
K
K
Shibuya
M
M
D000483:Alleles; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D005260:Female; D018237:Germinoma / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D013724:Teratoma / Q000235:genetics