Mixed connective tissue disease associated with multicentric Castleman's disease.
We describe a 60-year-old woman who developed mixed connective tissue disease (MCTD) associated with multicentric Castleman's disease (MCD) and Crow-Fukase syndrome (CFS). She showed HLA DR-4 antigen and an abnormal X chromosome (47,XXX). The serum interleukin-6 (IL-6) level was markedly increased and IL-6 mRNA was detected in enlarged lymph node cells. After prednisolone was administered, her IL-6 level decreased and the symptoms of MCTD, MCD, and CFS all improved. Thus, IL-6 may be involved in the modification of the pathologic condition in this patient.
Nanki
T
T
Department of Internal Medicine, Tokyo Metropolitan Bokuto General Hospital, Japan.
Tomiyama
J
J
Arai
S
S
D005871:Castleman Disease / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005260:Female; D015804:HLA-DR4 Antigen / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000235:genetics / Q000276:immunology; D016878:POEMS Syndrome / Q000150:complications* / Q000235:genetics / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D012729:Sex Chromosome Aberrations; D014960:X Chromosome
D015804:HLA-DR4 Antigen; D015850:Interleukin-6; D011239:Prednisolone