title: Evidence for downregulation of hypothalamic 5-hydroxytryptamine receptor function in endurance-trained athletes.
abstract: Serum prolactin (PRL) was used as a hormone marker of serotoninergic function following oral administration of an acute dose of a serotoninergic agonist. Five male endurance-trained athletes (ET) and five healthy non-endurance-trained controls (NT) were studied. The peak PRL concentration was lower (P = 0.031) for the ET athletes (486 +/- 208 mU l-1; mean +/- S.D.) than for the NT controls (1000 +/- 385 mU l-1); the total release of PRL was also lower (P = 0.042) for the ET subjects. The lower neuroendocrine response to a serotoninergic agonist in the endurance-trained athletes suggests a downregulation of central serotoninergic receptor function in response to endurance training in man.
authors.affiliation: Department of Medicine, University of Birmingham.
authors.forename: P M
authors.initials: PM
authors.lastname: Jakeman
authors.forename: J E
authors.initials: JE
authors.lastname: Hawthorne
authors.forename: S R
authors.initials: SR
authors.lastname: Maxwell
authors.forename: M J
authors.initials: MJ
authors.lastname: Kendall
authors.forename: G
authors.initials: G
authors.lastname: Holder
mesh_terms: D000328:Adult; D015536:Down-Regulation; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D010807:Physical Endurance; D011388:Prolactin / Q000097:blood; D011985:Receptors, Serotonin / Q000378:metabolism*; D012016:Reference Values
chemical_list: D011985:Receptors, Serotonin; D011388:Prolactin