The role of TH1 and TH2 cells in a rodent malaria infection.
CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.
Taylor-Robinson
A W
AW
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.
Phillips
R S
RS
Severn
A
A
Moncada
S
S
Liew
F Y
FY
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008212:Lymphocyte Depletion; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000378:metabolism*; D016788:Plasmodium chabaudi / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019323:omega-N-Methylarginine
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D009566:Nitrates; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine