[A stage IIIc ovarian cancer case of pathological CR after combination treatment with carboplatin and cisplatin].
Combination carboplatin and cisplatin (JP) is one of the new strategies for increasing dose intensity and total platinum dose in ovarian cancer chemotherapy. We treated a woman age 65, with stage IIIc ovarian cancer. At the first operation, the tumor size was 20 cm and could not be removed because of severe adhesion of intestine. After 4 courses of JP, she underwent second optimal surgery (total hysterectomy, bilateral salpingo-oophorectomy and omentectomy). There were no residual cancer cells microscopically in any specimen. Following 2 additional courses of JP, the patient is alive with no evidence of disease 18 months after the first operation. JP proved to be an efficacious strategy to increase platinum dose intensity for this advanced ovarian cancer.
Onishi
Y
Y
Dept. of Obstetrics and Gynecology, Kagoshima City Hospital.
Maruyama
H
H
Kume
K
K
Hatae
M
M
D000231:Adenocarcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D012074:Remission Induction
D016190:Carboplatin; D002945:Cisplatin