[Effects of beta-endorphin on blood pressure and heart rate in rats].
The present work was undertake to investigate the mechanism of changes of blood pressure and heart rate induced by beta-endorphin (beta-End) after microinjection into the Nucleus Amygdaloideus Centralis (AC) of anaesthetized rats. The results were as follows: (1) beta-End (100, 250 pg/microliters) injected into AC decreased both blood pressure and heart rate. (2) Both these effects could be antagonized by naloxone and beta-End anti-serum. (3) The effects of beta-End could also be reversed by phentolamine and propranolol. The results showed that the cardiovascular effects on beta-End were mediated by opioid receptors and through the intervention of adrenergic neurons.
Xiao
Q
Q
Department of Physiology, Naijong Medical College.
Chen
Q S
QS
Yan
Z H
ZH
Yang
R
R
Dai
Y L
YL
D000679:Amygdala / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009270:Naloxone / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D001615:beta-Endorphin / Q000494:pharmacology*
D009270:Naloxone; D001615:beta-Endorphin; D011433:Propranolol; D010646:Phentolamine