title: Reduced collateral perfusion is a direct consequence of elevated right atrial pressure.
abstract: In the present study we determined quantitatively the effects of increased right atrial pressure (RAP) on coronary and collateral flows. In an isolated, blood-perfused, maximally vasodilated dog heart preparation in which the left ventricle was vented, we used the retrograde flow method to assess collateral flow. When RAP was elevated from 5 +/- 1 (control) to 13 +/- 1 and 23 +/- 1 mmHg, retrograde flow from the left circumflex coronary artery (which was open to atmospheric pressure) increased 29 +/- 8 and 97 +/- 21% relative to control while left anterior descending flow decreased 5 +/- 1 and 14 +/- 2%, respectively (P < 0.01; n = 7). The increase in retrograde flow could be due to 1) an increase in collateral flow due to increased pressure at the origin of the collaterals or 2) the elevated RAP (venous outflow pressure), which forces the antegrade collateral flow component in the retrograde direction. To distinguish between these possibilities we embolized the circumflex with 30-microns spheres to eliminate the antegrade flow component. After embolization there was no significant change in retrograde flow with elevated RAP, indicating that the second supposition was correct. We conclude that increased RAP 1) results in a reduction of flow to the collateral-dependent myocardium and 2) reduces perfusion of the unoccluded coronary vessel. Furthermore, we found that under conditions of varying venous outflow pressure, retrograde flow may not serve as a reliable index of collateral flow.
authors.affiliation: Department of Physiology, University of North Texas Health Science Center at Fort Worth 76107.
authors.forename: D
authors.initials: D
authors.lastname: Manor
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Ator
authors.forename: K
authors.initials: K
authors.lastname: Bryant
authors.forename: K W
authors.initials: KW
authors.lastname: Scheel
mesh_terms: D000818:Animals; D016280:Atrial Function, Right; D003097:Collateral Circulation; D003326:Coronary Circulation; D004285:Dogs; D066298:In Vitro Techniques; D008863:Microspheres; D010477:Perfusion; D011312:Pressure