title: Disseminated metastatic cutaneous Crohn's disease.
abstract: Metastatic cutaneous Crohn's disease, in which noncaseating granulomatous infiltration of the skin occurs at sites separated from the gastrointestinal tract by normal tissue, is the least common dermatological manifestation of Crohn's disease. We report the case of an 18-year-old man who developed very widespread metastatic cutaneous Crohn's disease 2 years after he had first developed mild oral and anal lesions. His gastrointestinal symptoms had been satisfactorily controlled for 18 months with sulphasalazine alone prior to his developing skin lesions. The cutaneous lesions responded rapidly to oral prednisolone which was tailed off over 5 months and then withdrawn. He relapsed 6 months later and now requires a low dose of oral prednisolone to control the skin lesions. The only complication of this therapy has been exacerbation of mild acne vulgaris.
authors.affiliation: University Department of Dermatology, Royal Infirmary of Edinburgh, Scotland, UK.
authors.forename: S
authors.initials: S
authors.lastname: Peltz
authors.forename: J P
authors.initials: JP
authors.lastname: Vestey
authors.forename: A
authors.initials: A
authors.lastname: Ferguson
authors.forename: J A
authors.initials: JA
authors.lastname: Hunter
authors.forename: K
authors.initials: K
authors.lastname: McLaren
mesh_terms: D000293:Adolescent; D003424:Crohn Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D012460:Sulfasalazine / Q000627:therapeutic use
chemical_list: D012460:Sulfasalazine; D011239:Prednisolone