title: [Genetics and cancer of the breast].
abstract: Breast carcinoma is the commonest cancer in women. Segregation analyses support the existence of a major susceptibility gene with a dominant pattern of inheritance in 4 to 10% of cases. Three genes involved in the genetic predisposition to breast tumors have recently been identified: BRCA-1 associated with early onset familial breast cancer and breast/ovarian carcinoma syndrome, p53 associated with Li-Fraumeni syndrome, and the androgen receptor gene in male breast cancer with Reinfenstein syndrome. A better understanding of inherited contribution may have important implications for screening individuals at high-risk in families.
authors.forename: H
authors.initials: H
authors.lastname: Sobol
authors.forename: Y J
authors.initials: YJ
authors.lastname: Bignon
authors.forename: F
authors.initials: F
authors.lastname: Eisinger
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
authors.forename: B
authors.initials: B
authors.lastname: Fervers
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics*; D008297:Male; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics*
vernacular_title: Génétique et cancer du sein.