SDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats.
The effects of SDZ-205,152, a synthetic mixed D1/D2 dopamine receptor agonist, was investigated in rats trained to orally self-administer ethanol (10% w/v) in a free-choice, two-lever operant task. Pretreatment with SDZ-205,152, at doses of 0.5-5.0 mg/kg subcutaneously 30 min prior to limited access to 10% ethanol and water, selectively reduced ethanol-reinforced responding without affecting responses for water. These results demonstrate that ethanol-reinforced responding was attenuated by SDZ-205,152 and suggests that dopamine neural systems may mediate, in part, the reinforcing properties associated with voluntary ethanol self-administration.
Rassnick
S
S
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Pulvirenti
L
L
Koob
G F
GF
D000818:Animals; D015259:Dopamine Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000502:physiology; D012646:Self Administration
D015259:Dopamine Agents; D007211:Indoles; D017448:Receptors, Dopamine D2; D000431:Ethanol; C070723:SDZ 205-152