Has iprindole an alpha adrenergic activity?
1. Acute administration of iprindole potentiated the toxicity of 1-norepinephrine and increased the intensity of oxotremorine-induced tremors. 2. On the forced swimming test combination iprindole with imipramine reduced the duration of immobility. 3. The action of yohimbine on the locomotor activity was antagonized by a pre-injection of iprindole. 4. Iprindole increased and prolonged exophthalmia and loss of righting reflex induced by xylazine. 5 All these results seems indicate that iprindole has an indirect alpha 1 and alpha 2 adrenergic activity.
Ganry
H
H
Département de Pharmacologie et GIS Médicament, Faculté de Médecine, Nantes France.
Bourin
M
M
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D005094:Exophthalmos / Q000139:chemically induced / Q000517:prevention & control; D007488:Iprindole / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000633:toxicity; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D004856:Postural Balance / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013550:Swimming; D014991:Xylazine
D000316:Adrenergic alpha-Agonists; D011942:Receptors, Adrenergic, alpha; D014991:Xylazine; D010095:Oxotremorine; D007488:Iprindole; D009638:Norepinephrine; D011224:Prazosin