An experimental model to study the blink reflex.
A model to study the blink reflex in the experimental setting has been established. The behavioral, electrophysiologic, pathologic, and surgical methods and results obtained parallel those utilized and observed in the human and simulate the problem of facial paralysis. The observation that the blink can be elicited in an animal model, with the same stimuli as in humans, strengthens the value of this model, as do the similarities seen in the electrophysiologic recordings of NCV studies. The dual innervation of the rat eye sphincter allows application of the principle of selectively neurectomizing eye branches and "borrowing" motor-nerve fibers from the normal side, without causing eye-sphincter paralysis, a concept employed extensively in cross-facial nerve-grafting procedures in humans with facial paralysis.
Terrell
G S
GS
Microsurgical Research Center, Eastern Virginia Medical School, Norfolk 23507.
Terzis
J K
JK
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001369:Axons / Q000473:pathology / Q000502:physiology; D001767:Blinking / Q000502:physiology*; D004195:Disease Models, Animal; D004576:Electromyography / Q000295:instrumentation; D005143:Eyelids / Q000294:innervation; D005154:Facial Nerve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005158:Facial Paralysis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods; D008959:Models, Neurological; D009045:Motor Endplate / Q000473:pathology / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology; D016067:Nerve Transfer / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012025:Reflex, Pupillary / Q000502:physiology