Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.
Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage of breast and breast-ovarian cancers is significant in France and supports the existence of more than one susceptibility gene.
Mazoyer
S
S
Unité d'Oncologie Génétique, Centre Léon Bérard, Lyons, France.
Lalle
P
P
Narod
S A
SA
Bignon
Y J
YJ
Courjal
F
F
Jamot
B
B
Dutrillaux
B
B
Stoppa-Lyonnett
D
D
Sobol
H
H
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D016009:Chi-Square Distribution; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D005192:Family Health; D005260:Female; D005602:France; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes
D005819:Genetic Markers