title: Is the elimination of endotoxin and cytokines with continuous lavage an alternative procedure in necrotizing enterocolitis?
abstract: Ascites fluid was obtained intraoperatively in 12 consecutively treated neonates (6M, 6F, mean weight 940 g, mean gestational age 27th week, lethality 3/12) suffering from necrotizing enterocolitis (NEC). The concentrations of endotoxin and cytokines (IL-1, IL-6, TNF) were determined. Endotoxin and interleukins were excessively elevated in all patients, TNF only in those who survived. Postoperative treatment included the use of a continuous abdominal lavage system. This therapeutical procedure allows the elimination of endotoxin and cytokines out of the abdominal cavity in order to reduce their adverse biological effect.
authors.affiliation: Department of General Surgery, University Ulm, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Birk
authors.forename: D
authors.initials: D
authors.lastname: Berger
authors.forename: J
authors.initials: J
authors.lastname: Limmer
authors.forename: H G
authors.initials: HG
authors.lastname: Beger
mesh_terms: D001201:Ascites / Q000276:immunology* / Q000382:microbiology; D003131:Combined Modality Therapy; D016207:Cytokines / Q000032:analysis* / Q000502:physiology; D004731:Endotoxins / Q000032:analysis* / Q000502:physiology; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology* / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007375:Interleukin-1 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D010533:Peritoneal Lavage; D015996:Survival Rate; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D016207:Cytokines; D004731:Endotoxins; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha