Loss of Y chromosome. An age-related event or a cytogenetic marker of a malignant clone?
Cytogenetic analysis of bone marrow cells performed at the time of diagnosis of ALL in an 80-year-old male patient revealed two unrelated abnormal clones. One included the 9;22 translocation (Philadelphia chromosome) as the sole aberration and the second was missing the Y chromosome. The significance of this finding in the light of the role of -Y clone in malignancy is discussed.
Abeliovich
D
D
Department of Human Genetics, Hadassah Hebrew University Hospital, Ein Kerem, Jerusalem, Israel.
Yehuda
O
O
Ben-Neriah
S
S
Or
R
R
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D002869:Chromosome Aberrations; D002999:Clone Cells; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014998:Y Chromosome