Activity of alpha-anilinobenzyl cyanides and 2-methoxycarbonylamino-1-phenylimidazoles, a new class of antifilarial agents.
The activity of alpha-anilinobenzyl cyanides (2a-f), 5-aryl-4,5-dihydro-2-methoxycarbonylamino-1-phenylimidazoles (5a-d) and 2-methoxycarbonylamino-1-phenyl-1,3-diazaspiro[4:5]dec-2-ene (5f) have been tested for their micro- and macrofilaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodents. In this test alpha-anilinobenzyl cyanides (2a-b), 5-(4-methoxyphenyl)-4,5-dihydro-2-methoxy-carbonylamino-1-phenylim idazole (5b) and 2-methoxycarbonylamino-1-phenyl-1,3-diazaspiro[4:5]dec-2-ene (5f) were found to possess marked filaricidal activity at doses ranging from 3-100 mg/kg given parenterally or orally for 5 days.
Naim
S S
SS
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India.
Srivastava
V
V
Sharma
S
S
Singh
S N
SN
Fatima
N
N
Chatterjee
R K
RK
D000818:Animals; D003486:Cyanides / Q000138:chemical synthesis* / Q000627:therapeutic use; D004153:Dipetalonema; D004154:Dipetalonema Infections / Q000188:drug therapy* / Q000469:parasitology; D004353:Drug Evaluation, Preclinical; D005369:Filaricides / Q000138:chemical synthesis* / Q000627:therapeutic use; D005370:Filarioidea; D007093:Imidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D016205:Sigmodontinae / Q000469:parasitology*
D003486:Cyanides; D005369:Filaricides; D007093:Imidazoles