3-dimensional functional imaging of human brain using echo-shifted FLASH MRI.
A 3-dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo-shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.
Duyn
J H
JH
Laboratory of Diagnostic Radiology Research, OIR, NIH, Bethesda, Maryland 20892.
Mattay
V S
VS
Sexton
R H
RH
Sobering
G S
GS
Barrios
F A
FA
Liu
G
G
Frank
J A
JA
Weinberger
D R
DR
Moonen
C T
CT
D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*