Accuracy in clinical chemistry--does anybody care?
The role of clinical chemistry in the diagnostic process has been enhanced by the evolution of better instrumentation and analytical techniques. The quality of some laboratory tests, however, has not kept pace with these advances. I present three examples--serum iron, serum lipase, and nonisotopic immunoassays--assays where some currently used methodologies are highly flawed. Causes for the less than optimal performance of some clinical laboratories are discussed.
Tietz
N W
NW
Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington 40536-0084.
D002624:Chemistry, Clinical / Q000331:legislation & jurisprudence / Q000592:standards / Q000706:statistics & numerical data*; D006801:Humans; D007118:Immunoassay / Q000592:standards / Q000706:statistics & numerical data; D007501:Iron / Q000097:blood; D008049:Lipase / Q000097:blood; D011786:Quality Control; D012680:Sensitivity and Specificity; D014481:United States; D014486:United States Food and Drug Administration
D007501:Iron; D008049:Lipase