title: Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen.
abstract: A cDNA clone encoding a psychrophilic cod chymotrypsinogen has been isolated and characterized. The predicted amino acid sequence reveals a preproenzyme of 263 amino acids containing a unique 18 residue signal sequence. Amino acid sequence identity between the cod and mammalian chymotrypsinogens is 64-68%. Two highly conserved proline residues are substituted in cod chymotrypsin.
authors.affiliation: Science Institute, University of Iceland, Reykjavík.
authors.forename: A
authors.initials: A
authors.lastname: Guthmundsdóttir
authors.forename: S
authors.initials: S
authors.lastname: Oskarsson
authors.forename: A E
authors.initials: AE
authors.lastname: Eakin
authors.forename: C S
authors.initials: CS
authors.lastname: Craik
authors.forename: J B
authors.initials: JB
authors.lastname: Bjarnason
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001267:Atlantic Ocean; D001483:Base Sequence; D002919:Chymotrypsinogen / Q000145:classification / Q000235:genetics*; D003001:Cloning, Molecular; D003080:Cold Temperature; D018076:DNA, Complementary / Q000235:genetics; D004792:Enzyme Precursors / Q000235:genetics*; D005399:Fishes / Q000235:genetics*; D008386:Marine Biology; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D004792:Enzyme Precursors; C040066:prechymotrypsinogen 2; D002919:Chymotrypsinogen