Reactive oxygen species and antioxidant vitamins: mechanisms of action.
This article is a brief overview of the mechanisms of production of reactive oxygen species in biologic systems, and the various antioxidant defense systems that provide protection against oxidative damage to biologic macromolecules. The mechanisms of lipid peroxidation and antioxidant protection are explained using a specific example, viz., oxidative modification of human low density lipoprotein and its prevention by vitamin C, vitamin E, and beta-carotene.
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Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts 02118.
D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*; D019207:beta Carotene
D000975:Antioxidants; D008077:Lipoproteins, LDL; D017382:Reactive Oxygen Species; D014815:Vitamins; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid