title: Effects of the CCK receptor antagonist MK-329 on food intake in broiler chickens.
abstract: The cholecystokinin (CCK) receptor antagonist MK-329 (previously L-364,718) was administered intraperitoneally to free-feeding broiler chickens and tested for conditioning effects using the colored food paradigm. The 8.0, 16.0, and 32.0 micrograms/kg doses of MK-329 did not exert any effect on food intake and failed to condition a color preference or aversion. When higher doses were used (90, 180, and 360 micrograms/kg) MK-329 caused a significant increase in food intake during the 2-h test period. Intravenously injected MK-329 (70, 140, and 280 micrograms/kg) produced an increase in food intake, with maximum increases occurring at a dose of 70 micrograms/kg. CCK (14 micrograms/kg) caused a reduction in feeding, and this effect was not blocked by pretreatment with intraperitoneal injection of MK-329 (32, 90, 180, and 360 micrograms/kg). The results question the role of endogenous CCK in satiety in chickens.
authors.affiliation: Department of Animal Physiology and Nutrition, University of Leeds, UK.
authors.forename: M
authors.initials: M
authors.lastname: Covasa
authors.forename: J M
authors.initials: JM
authors.lastname: Forbes
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002645:Chickens; D002766:Cholecystokinin / Q000502:physiology; D003116:Color; D020109:Devazepide; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005260:Female; D005518:Food Preferences / Q000187:drug effects; D007274:Injections, Intraperitoneal; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*
chemical_list: D001570:Benzodiazepinones; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D020109:Devazepide