title: Translocation 8;21 associated with acute nonlymphocytic leukemia in a Down syndrome child.
abstract: A boy with Down syndrome who developed acute nonlymphocytic leukemia (ANLL/M2) at the age of 40 months is presented. Chromosomal analysis of cultured peripheral blood cells without mitogen revealed a constitutional abnormality, trisomy 21, associated with the acquired chromosome change t(8;21)(q22;q22).
authors.affiliation: Department of Pediatrics, Medical University of Debrecen, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Balogh
authors.forename: E
authors.initials: E
authors.lastname: Oláh
authors.forename: K
authors.initials: K
authors.lastname: Hunyadi
mesh_terms: D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic