title: Differential decrease of copper content and of copper binding to superoxide dismutase in liver, heart and brain of copper-deficient rats.
abstract: Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an apo-form of superoxide dismutase, which can be reactivated by addition of exogenous copper to tissue extracts. These results demonstrate in vivo that superoxide dismutase is post-translationally modulated by copper in higher vertebrates as previously found for yeast and mammalian cells in culture.
authors.affiliation: Department of Biology, Tor Vergata University of Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Rossi
authors.forename: M R
authors.initials: MR
authors.lastname: Ciriolo
authors.forename: E
authors.initials: E
authors.lastname: Marchese
authors.forename: A
authors.initials: A
authors.lastname: De Martino
authors.forename: M
authors.initials: M
authors.lastname: Giorgi
authors.forename: G
authors.initials: G
authors.lastname: Rotilio
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000172:deficiency* / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D003300:Copper; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D012643:Selenium