In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
Spectral changes upon death (global ischemia) were recorded in situ in cat cerebral cortex. A rapid signal loss of 10 +/- 4% in the N-acetyl resonance was observed (five cases), after which it remained constant for 1 h. For the first time signal changes are reported for low-field resonances, which are assigned to adenosine/inosine and hypoxanthine.
van Zijl
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PC
Georgetown University Medical School, Department of Pharmacology, Rockville, Maryland.
Moonen
C T
CT
D000107:Acetylation; D000241:Adenosine / Q000032:analysis / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D002415:Cats; D002794:Choline / Q000032:analysis / Q000378:metabolism; D003401:Creatine / Q000032:analysis / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D005971:Glutamates / Q000032:analysis / Q000378:metabolism; D018698:Glutamic Acid; D005998:Glycine / Q000032:analysis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011685:Purine Nucleotides / Q000032:analysis / Q000378:metabolism*; D013654:Taurine / Q000032:analysis / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism
D005971:Glutamates; D011685:Purine Nucleotides; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C000179:N-acetylaspartate; D005947:Glucose; D000241:Adenosine; D003401:Creatine; D002794:Choline; D005998:Glycine