Increased expression of transforming growth factor-beta in renal disease.
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine and a major regulator of tissue repair and extracellular matrix. Recent studies show that TGF-beta overexpression in experimental and human kidney diseases leads to progressive glomerular and tubulointerstitial scarring and renal failure. New evidence suggests that angiotensin-converting enzyme inhibitors and a low-protein diet may slow the progression of chronic kidney diseases in part by suppressing TGF-beta overexpression. New therapies may prevent progressive fibrosis in chronic kidney disease by suppressing the action of TGF-beta.
Ketteler
M
M
University of Utah School of Medicine, Salt Lake City.
Noble
N A
NA
Border
W A
WA
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D015870:Gene Expression; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000628:therapy; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D015854:Up-Regulation
D016212:Transforming Growth Factor beta