Quantitative and qualitative modifications of lymphocyte subsets after sublingual administration of isosorbide dinitrate in migraineurs. Preliminary report.
In 22 migraine patients and 5 healthy controls an investigation has been performed on lymphocyte subsets in basal conditions and 90 minutes after sublingual isosorbide dinitrate (IDN) administration. In all patients the drug assumption induced a typical migraine attack with increase in all examined lymphocyte subsets with except of NK cells. A statistically significant increase (p < 0.05) in T lymphocyte subsets we found during the crisis, whereas in healthy controls neither a migraine attack nor any modification in lymphocyte subsets could be observed. These results seem to confirm the immune alteration we have previously found in migraineous patients and suggest the possible role of IDN-stimulated endothelium not only in vasodilatation but also in production of substances responsible of the observed immune modifications.
Massari
F
F
Clinica Neurologica, Università degli Studi Federico II, Napoli.
D'Andrea
L
L
Cervo
M A
MA
Serra
F P
FP
Covelli
V
V
Buscaino
G A
GA
D000286:Administration, Sublingual; D000328:Adult; D016207:Cytokines / Q000378:metabolism; D005069:Evaluation Studies as Topic; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D007548:Isosorbide Dinitrate