title: An investigation of urinary creatine excretion as a potential marker for testicular damage.
abstract: 1. This study assessed urinary creatine excretion as a marker for testicular atrophy. 2. Male rats received a single i.p. dose of 2-methoxyethanol at 0, 250 or 750 mg kg-1 and were sacrificed 2 d later. Urinary creatine and creatinine excretion were measured on days 0, 1 and 2. 3. Decreased testicular weights and histopathological assessment revealed dose-related testicular damage. 4. On day 1, at both doses of 2-methoxyethanol, urinary creatine levels increased and creatinine levels decreased, resulting in a dose-related increase in the creatine/creatinine ratio. On day 2, the creatine/creatinine ratio was elevated relative to controls, but was less marked than on day 1. 5. The study confirmed that creatine excretion is a potential marker for acute testicular damage.
authors.affiliation: Laboratoires Pfizer, Centre de Recherche, Amboise, France.
authors.forename: K
authors.initials: K
authors.lastname: Nahas
authors.forename: J L
authors.initials: JL
authors.lastname: le Net
authors.forename: J P
authors.initials: JP
authors.lastname: Provost
authors.forename: K E
authors.initials: KE
authors.lastname: Tomaszewski
mesh_terms: D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D015415:Biomarkers / Q000652:urine; D003401:Creatine / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005026:Ethylene Glycols / Q000633:toxicity; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013733:Testicular Diseases / Q000139:chemically induced / Q000473:pathology / Q000652:urine*
chemical_list: D015415:Biomarkers; D005026:Ethylene Glycols; D003404:Creatinine; C005219:methyl cellosolve; D003401:Creatine