title: The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein.
abstract: A gene has been cloned from the yeast Saccharomyces cerevisiae which, on the basis of the deduced translation product, encodes a sugar transporter-like protein. This gene, STL1, was identified as an open reading frame (ORF) closely linked to the cinnamic-acid-resistance gene POF1 on chromosome IV. The putative translation product of STL1 (STL1) contains 536 amino acids, with a M(r) of 60,507. Hydropathy analysis of STL1 suggests that it contains the twelve transmembrane (TM) domains characteristic of a family of sugar transporters from S. cerevisiae and other organisms. STL1 displays greatest homology (28% identity) to the products of the yeast HXT2 (hexose transporter) and GAL2 (galactose transporter) genes. Disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source. The transport function of the gene product remains unknown at present.
authors.affiliation: International Centre for Brewing and Distilling, Heriot-Watt University, Riccarton, Edinburgh, UK.
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: N W
authors.initials: NW
authors.lastname: Douglas
authors.forename: M J
authors.initials: MJ
authors.lastname: Heine
authors.forename: G M
authors.initials: GM
authors.lastname: Williams
authors.forename: H C
authors.initials: HC
authors.lastname: Winther-Larsen
authors.forename: P G
authors.initials: PG
authors.lastname: Meaden
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics* / Q000302:isolation & purification; D005800:Genes, Fungal / Q000235:genetics*; D016350:Leucine Zippers / Q000235:genetics; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000235:genetics* / Q000302:isolation & purification; D016366:Open Reading Frames / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins; D009004:Monosaccharide Transport Proteins