title: [A plasmid-mediated SHV type extended-spectrum beta-lactamase in Beijing isolate of Enterobacter gergoviae].
abstract: By conjugation experiment, an extended-spectrum beta-lactamase (ESb1a) encoded on a transferable plasmid of approximately 60 Kilobases was found in a clinical strain of Enterobacter gergoviae isolated from Peking Union Medical College Hospital. Its E. coli transconjugant was resistant to all beta-lactams tested except cefoxitin and imipenem. Clavulanic acid, a classical beta-lactamase inhibitor, inhibited its activity. Hybridization with an intragenic probe for SHV-1 revealed that this ESb1a may be related to, or derived from SHV enzyme.
authors.affiliation: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D002442:Ceftazidime; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D005798:Genes, Bacterial; D011815:R Factors / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D002969:Clavulanic Acids; D019818:Clavulanic Acid; D002442:Ceftazidime; D001618:beta-Lactamases