Umbilical cord blood stem cell transplantation.
OBJECTIVE
Human umbilical cord blood is a new source of hematopoietic stem cells.


METHODS
On the basis of prior laboratory investigations in an animal model and subsequent in vitro studies of human hematopoietic progenitors, umbilical cord blood was used to reconstitute hematopoiesis in a patient with Fanconi anemia in 1988. As a result of this first success, umbilical cord blood has been used in the treatment of 15 children with a variety of malignant and nonmalignant diseases, including acute and chronic leukemia, lymphoma, neuroblastoma, Fanconi anemia, aplastic anemia, Hunter syndrome, and congenital immunodeficiency.


CONCLUSIONS
This review summarizes the brief history and potential future applications of cord blood stem cells (CBSCs) in transplantation.
Wagner
J E
JE
Department of Pediatrics (Divisions of Hematology/Oncology and Bone Marrow Transplantation, University of Minnesota School of Medicine, Minneapolis.
D000818:Animals; D001793:Blood Preservation; D001800:Blood Specimen Collection; D002478:Cells, Cultured; D002648:Child; D002986:Clinical Trials as Topic; D015925:Cryopreservation; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011247:Pregnancy; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology