title: Non-Hodgkin's lymphoma in a patient with follicular thyroid cancer: the role of 99mTc-methoxy isobutyl isonitrile imaging.
abstract: In the post-surgical follow-up of a patient with follicular thyroid carcinoma, a palpable mass in the left supraclavicular region was highly indicative of metastatic disease. Technetium-99m methoxy isobutyl isonitrile (99mTc-MIBI) showed an increased but heterogeneous uptake within the lesion. Surprisingly, a different neoplastic disease was histologically demonstrated. Lymph node abnormalities due to non-Hodgkin's lymphoma rather than metastatic thyroid disease were demonstrated. In conclusion, non-Hodgkin's lymphoma may occur in patients with follicular thyroid carcinoma. This new lesion significantly concentrated 99mTc-MIBI. Thus, the results of 99mTc-MIBI imaging have to be carefully evaluated during the follow-up of patients with thyroid cancer.
authors.affiliation: Department of Nuclear Medicine, National Cancer Institute, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Maurea
authors.forename: S
authors.initials: S
authors.lastname: Lastoria
authors.forename: M
authors.initials: M
authors.lastname: Klain
authors.forename: L
authors.initials: L
authors.lastname: Celentano
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging*; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D017256:Technetium Tc 99m Sestamibi