title: Heterogeneity of small plasmids from halophilic archaea.
abstract: Small multicopy plasmids in three strains of halophilic archaea, SB3, GRB, and GN101, were found to be present in a cell as a population of related but not identical sequences. Two types of heterogeneity were observed: macroheterogeneity, represented by two major plasmid sequence versions homologous to each other by 80%, and microheterogeneity, in which individual plasmids differ by one or a few nucleotide substitutions.
authors.affiliation: Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Akhmanova
authors.forename: V K
authors.initials: VK
authors.lastname: Kagramanova
authors.forename: A S
authors.initials: AS
authors.lastname: Mankin
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics*; D006217:Halobacterium / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010957:Plasmids; D012150:Polymorphism, Restriction Fragment Length; D016415:Sequence Alignment; D013045:Species Specificity
chemical_list: D004269:DNA, Bacterial