Translocation 8;21 associated with acute nonlymphocytic leukemia in a Down syndrome child.
A boy with Down syndrome who developed acute nonlymphocytic leukemia (ANLL/M2) at the age of 40 months is presented. Chromosomal analysis of cultured peripheral blood cells without mitogen revealed a constitutional abnormality, trisomy 21, associated with the acquired chromosome change t(8;21)(q22;q22).
Balogh
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Department of Pediatrics, Medical University of Debrecen, Hungary.
Oláh
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Hunyadi
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K
D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic