[Antimutagens as modifiers of the cellular cyclase system].
Ability of adenosine, caffeine, theophylline, cAMP, dimephosphone, PABA and tocopherol acetate to modify the rate of mutagenesis induced as well as to affect the content of endogenous cAMP were studied in experiments with seeds of Crepis capillaries. Those concentrations of these drugs which decreased the rate of mutations, were shown to increase the content of endogenous cAMP in the seeds. Higher concentrations of the drugs did not exhibit any antimutagenic activity as well as did not contribute to an increase in the cAMP content, but sometimes decreased distinctly cyclonucleotide content in the seeds.
Semenov
V V
VV
Studentsova
I A
IA
Durnev
A D
AD
Seredenin
S B
SB
Vizel'
A O
AO
D000262:Adenylyl Cyclases / Q000187:drug effects*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016296:Mutagenesis
D016587:Antimutagenic Agents; D000242:Cyclic AMP; D000262:Adenylyl Cyclases
Antimutageny kak modifikatory tsiklaznoĭ ssistemy kletki.