Epidermodysplasia verruciformis accompanied by familial large granular lymphocytosis and a decrease in T lymphocytes.
A 40-year-old man with epidermodysplasia verruciformis showed a decrease in peripheral blood T cells and abnormal expansion of large granular lymphocytes, accompanied by increased natural killer cell activity. Surface marker analysis of his large granular lymphocytes demonstrated that the subset, CD 57+ and CD 16+, had increased. His father, who had no skin lesions of epidermodysplasia verruciformis, displayed similar blood changes and his brother showed a decrease in T cells and a slight increase in CD 16+ natural killer cells, whereas his mother revealed only a slight decrease in T cells. Our present study indicates that epidermodysplasia verruciformis might be associated with hereditary abnormal expansion of large granular lymphocytes and a decrease in T cells.
Aoyama
H
H
Department of Dermatology, School of Medicine, Tohoku University, Sendai, Japan.
Seki
S
S
Abo
T
T
Usuba
Y
Y
Tomita
Y
Y
Tagami
H
H
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D008297:Male; D010375:Pedigree; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface