Antibody neutralization of picornaviruses: can fever help?
Binding of bivalent antibody can neutralize picornaviruses by a variety of mechanisms. Some monoclonal antibodies can irreversibly neutralize the virus at temperatures that are higher than physiological by disrupting the virion, leading to ejection of the RNA. Fever may enhance this process in vivo, confirming the popular belief in the virtues of fever.
Boeyé
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Dept of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
Delaet
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Brioen
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D005334:Fever / Q000276:immunology*; D006801:Humans; D010849:Picornaviridae / Q000276:immunology*; D010850:Picornaviridae Infections / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral