Successful adoptive immunotherapy with lymphokine-activated killer cells in the treatment of medulloblastoma disseminated via cerebrospinal fluid: case report.
We report the case of a girl who developed cerebellar medulloblastoma at the age of 12 years and in whom, 4 years after surgical removal and radiotherapy, neoplastic dissemination via the cerebrospinal fluid took place. After only partially effective systemic and intrathecal chemotherapy, an intrathecal administration of lymphokine-activated killer cells and recombinant interleukin-2 allowed complete clinical recovery persisting after a follow-up of 30 months.
Silvani
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A
Istituto Nazionale Neurologico C. Besta, Milan, Italy.
Salmaggi
A
A
Parmiani
G
G
Boiardi
A
A
D000328:Adult; D002460:Cell Line; D002528:Cerebellar Neoplasms / Q000276:immunology / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma; D006801:Humans; D016219:Immunotherapy, Adoptive; D007276:Injections, Intraventricular; D007376:Interleukin-2 / Q000008:administration & dosage; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology / Q000637:transplantation*; D008297:Male; D008527:Medulloblastoma / Q000276:immunology / Q000628:therapy*
D007376:Interleukin-2