title: [Bias of index of T-lymphocytes and chronic inflammatory dermatoses].
abstract: The pathogenesis of chronic inflammatory and autoimmune diseases is still not understood. The hypothesis that a bias in the T cell receptor repertoire could explain the susceptibility of some individuals to a particular disease was recently proposed on the basis of results obtained in animal models of human diseases. In this review, we focus on the structure of the T cell receptor and on the new insights in the study of the T cell repertoire in human inflammatory diseases, with special emphasis to skin disorders.
authors.affiliation: Laboratoire Greca, Institut Gustave-Roussy, Villejuif, France.
authors.forename: H
authors.initials: H
authors.lastname: Michalaki
authors.forename: J F
authors.initials: JF
authors.lastname: Nicolas
authors.forename: H
authors.initials: H
authors.lastname: Bour
authors.forename: A
authors.initials: A
authors.lastname: Demidem
authors.forename: D
authors.initials: D
authors.lastname: Schmitt
mesh_terms: D000917:Antibody Formation / Q000276:immunology*; D017252:CD3 Complex / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D002908:Chronic Disease; D003872:Dermatitis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D011948:Receptors, Antigen, T-Cell
vernacular_title: Biais du répertoire des lymphocytes T et dermatoses inflammatoires chroniques.