[Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model].
The effects of 4-week indomethacin administration (1mg/kg/day, orally) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E2 (PGE2) of gastric mucosa were examined in pyloric stenosis rats. As a result, pyloric stenosis rats showed hypergastrinemia, G-cell hyperplasia and D-cell hyperplasia with normal PGE2 concentration of gastric mucosa compared with sham operated rats. However, indomethacin administration completely abolished these endocrinic changes of pyloric stenosis by reducing PGE2 concentration of gastric mucosa in both fundic and pyloric regions. These results underline the importance of gastric mucosal PGE2 concentration on the proliferation of G-cells and D-cells in pyloric stenosis.
Omura
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Second Department of Surgery, Jikei University School of Medicine.
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011707:Pyloric Stenosis / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000097:blood
D005755:Gastrins; D013004:Somatostatin; D007213:Indomethacin