[Effect of high calcium intake on blood pressure and intracellular pH, Na(+)-H+ exchange activity in stroke-prone spontaneously hypertensive rats].
Effect of high calcium (3%) intake on blood pressure and intracellular pH, Na(+)-H+ exchange activity, cytosolic free calcium concentration in stroke-prone spontaneously hypertensive rats (SHRSP-Ca) is compared with sex-, ag-matched SHRSP and WKY rats without high calcium intake. The results showed that high calcium intake significantly suppressed increase in blood pressure and decreased cytosolic free calcium concentration after it was given to SHRSP-Ca for 6 weeks, while plasma calcium was increased. The intracellular pH tended to be in the normal range of WKY rats. Na(+)-H+ exchange activity was slightly decreased. Correlationship between blood pressure and intracellular pH, Na(+)-H+ exchange activity and cytosolic free calcium concentration were discussed.
Li
D Y
DY
Shanghai Institute of Hypertension, Shanghai Second Medical University.
Gu
D G
DG
Ayame
K
K
Yasuo
N
N
Katsumi
I
I
Chuzo
M
M
Yukio
Y
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism*
D017923:Sodium-Hydrogen Exchangers; D002118:Calcium