Insulin independence in type I diabetes after transplantation of unpurified islets from single donor with 15-deoxyspergualin.
Islet transplantation has been slow to develop as a therapy for type I diabetes mellitus. Conventional immunosuppression does not protect islet allografts from early failure and by current techniques the yield of purified islets from a single pancreas is inadequate or only marginally in excess of the number needed to sustain normoglycaemia. We transplanted unpurified islets from a single pancreas concomitantly with a kidney to two uraemic diabetic patients. The novel agent 15-deoxyspergualin, along with antilymphocyte globulin, was used for induction immunosuppression, and azathioprine, prednisone, and cyclosporin for maintenance. Islet function has been sustained in both, and the second patient is insulin-independent and euglycaemic more than 6 months after transplantation.
Gores
P F
PF
Department of Surgery, University of Minnesota, Minneapolis.
Najarian
J S
JS
Stephanian
E
E
Lloveras
J J
JJ
Kelley
S L
SL
Sutherland
D E
DE
D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage*; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014019:Tissue Donors
D000961:Antilymphocyte Serum; D006146:Guanidines; D007166:Immunosuppressive Agents; D007328:Insulin; D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; C037258:gusperimus; D011241:Prednisone