Age related changes in functions and physicochemical properties of rat jejunal brush border membrane after chronic ethanol administration.
1. We investigated the chronic effects of a 4 week treatment with ethanol on functions and physicochemical properties of BBM of young and adult rats (2 and 7 months old respectively). 2. In the ethanol treated groups the cholesterol/phospholipid and the protein/lipid ratios as well as the D-glucose uptake and lactase specific activity and Vmax were increased. In spite of a minor alcohol consumption the adult group was the more affected. 3. Membranes from the ethanol fed rats were less fluid and more tolerant to the in vitro addition of ethanol.
Lindi
C
C
Institute of General Physiology and Biochemistry, University of Milano, Italy.
Marciani
P
P
Omodeo-Sale
F
F
D000375:Aging / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D005454:Fluorescence Polarization; D005947:Glucose / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D043322:Lactase; D050356:Lipid Metabolism; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D001616:beta-Galactosidase / Q000378:metabolism
D043322:Lactase; D001616:beta-Galactosidase; D005947:Glucose