[Acute inflammatory polyradiculoneuritis during bone marrow transplantation. A report of 2 cases].
Acute polyradiculoneuritis (AP) is a self-immunity based disease of the peripheral nerve caused by macrophages, usually activated by T-lymphocytes. Recent clinical and experimental evidence show that early high dose treatment with Ig slows disease progression. In this study, two cases of AP with different onset in two patients showing definitely compromised cellular and/or humoral immunity, are reported. The hypothesis that the different temporal profiles may be related to a distinct involvement of the immunity system and the effectiveness of high dose Ig treatment in blocking the disease's evolution are discussed.
Carozzi
M
M
Divisione di Neuropsichiatria Infantile, Istituto per l'Infanzia Burlo Garofolo, Trieste, Italia.
De Manzini
A
A
Giorgi
A
A
Osbich
A
A
D000208:Acute Disease; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000276:immunology / Q000628:therapy
D016756:Immunoglobulins, Intravenous
Poliradicoloneurite infiammatoria acuta in corso di trapianto di midollo osseo. Descrizione di due casi.