title: Brain macrophages: neurotoxic or neurotrophic effector cells?
abstract: The development of the central nervous system and various pathological contexts imply remodeling or alteration of neuronal networks associated with tissue recruitment of mononuclear phagocytes. Purification and culture of brain macrophages have provided a tool for investigating the functions of these cells. We discuss different mechanisms whereby macrophages could directly influence the survival of neurons and the growth of their processes.
authors.affiliation: INSERM U114, Collège de France, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Mallat
authors.forename: B
authors.initials: B
authors.lastname: Chamak
mesh_terms: D001921:Brain / Q000166:cytology* / Q000502:physiology; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000166:cytology* / Q000502:physiology; D009451:Neuroeffector Junction / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D009498:Neurotoxins / Q000494:pharmacology
chemical_list: D009498:Neurotoxins