Effects of cholecystokinin tetrapeptide and sulfated cholecystokinin octapeptide in rat models of anxiety.
The effects of the acutely administered cholecystokinin (CCK) agonists CCK tetrapeptide (BOC-CCK-4) and sulfated CCK octapeptide (CCK-8S) were examined in four animal models of anxiety in rats. In the elevated plus maze, BOC-CCK-4 reduced the time spent in the open arms and the number of entries into the open arms. BOC-CCK-4 but not the anorectic acting CCK-8S increased the suppression of feeding in a conflict paradigm based on novelty suppressed feeding in hungry rats. In the two-compartment black-and-white box, BOC-CCK-4 decreased the time spent and locomotor activity in the white compartment. In the ultrasound vocalization test, using rat pups separated from the mother, BOC-CCK-4 increased the number of distress calls. No evidence was found for inducing anxiety-like behaviour by CCK-8S.
Rex
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Institute of Pharmacology and Toxicology, Medical Faculty (Charité), Humboldt University at Berlin, Germany.
Barth
T
T
Voigt
J P
JP
Domeney
A M
AM
Fink
H
H
D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000523:psychology; D001010:Anxiety, Separation / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D003220:Conflict, Psychological; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000494:pharmacology*; D013758:Tetragastrin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014828:Vocalization, Animal / Q000187:drug effects
D013758:Tetragastrin; C063051:butyloxycarbonyl-tryptophyl-methionyl-aspartyl-phenylalaninamide; D012844:Sincalide