title: [The clinical efficacy of the new drug agent ligentén in urology patients].
abstract: A clinical trial was made of a new gel ligenten intended for local urethral anesthesia and treatment of infection and inflammation in the lower urinary tracts. Ligenten was given to 52 patients to manage bladder, prostate, urethral infection and inflammation, for local prophylaxis before cystoscopy, urethral bouginage and transurethral surgery. Apparent advantages of intraurethral introduction of the analgetic compared to instrument lubrication are demonstrated. Ligenten was also effective against chronic cystitis, cystalgia and urethral syndrome in females, especially in ulcerative cystitis. The gel exhibited adequate antiinflammatory and analgetic effect. As a prophylactic means, it prevents inflammation in cystoscopy, urethral catheterization and transurethral operations. No severe side effects have been reported.
authors.forename: T S
authors.initials: TS
authors.lastname: Perepanova
authors.forename: A F
authors.initials: AF
authors.lastname: Darenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Kagan
authors.forename: G A
authors.initials: GA
authors.lastname: Kotliarova
authors.forename: E M
authors.initials: EM
authors.lastname: Kondrat'eva
authors.forename: L N
authors.initials: LN
authors.lastname: Lavrinova
authors.forename: N V
authors.initials: NV
authors.lastname: Grishkova
authors.forename: V N
authors.initials: VN
authors.lastname: Siniukhin
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005782:Gels; D005839:Gentamicins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008012:Lidocaine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005782:Gels; D005839:Gentamicins; C089167:Ligenten; D000644:Quaternary Ammonium Compounds; C004921:Ethonium; D008012:Lidocaine
vernacular_title: Klinicheskaia éffektivnost' novogo lekarstvennogo sredstva ligenténa u urologicheskikh bol'nykh.