title: Use of a more physiologic oral glucose solution during screening for gestational diabetes mellitus.
abstract: OBJECTIVE
  We sought to compare in pregnant women deviations in glucose values, insulin values, and the occurrence of side effects between a "standard" 50 gm oral glucose solution (50 gm of glucose in 150 ml of fluid, 1.85 mol/L) versus a modified "physiologic" 50 gm oral glucose solution (50 gm of glucose in 450 ml of fluid, 0.62 mol/L) as a screening test for gestational diabetes mellitus.
  
  
  METHODS
  A total of 132 pregnant women underwent (1) a standard 50 gm, 1-hour oral glucose screening test, (2) a 50 gm, 1-hour oral glucose screening test using the modified solution, and (3) a 3-hour oral glucose tolerance test (with 100 gm of glucose in 300 ml of fluid, 1.85 mol/L).
  
  
  RESULTS
  Compared with the "standard" regimen, both glucose and insulin values were significantly higher in the "modified" regimen 30 minutes after ingestion, indicating a more rapid absorption of glucose. Nausea and vomiting were greatly decreased with the modified glucose solution. The 1-hour glucose values were not statistically different.
  
  
  CONCLUSIONS
  A more dilute, more palatable oral glucose solution can be used to screen for gestational diabetes mellitus, yielding more accurate results and eliminating unpleasant side effects.
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio 78284-7750.
authors.forename: J G
authors.initials: JG
authors.lastname: Schwartz
authors.forename: W T
authors.initials: WT
authors.lastname: Phillips
authors.forename: M R
authors.initials: MR
authors.lastname: Blumhardt
authors.forename: O
authors.initials: O
authors.lastname: Langer
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000517:prevention & control*; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000009:adverse effects; D005951:Glucose Tolerance Test / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000097:blood; D008403:Mass Screening / Q000379:methods; D009325:Nausea / Q000139:chemically induced; D011247:Pregnancy; D012680:Sensitivity and Specificity; D012996:Solutions; D014839:Vomiting / Q000139:chemically induced
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012996:Solutions; D005947:Glucose