title: Humoral hypercalcemia of malignancy associated with ameloblastoma in a horse.
abstract: Humoral hypercalcemia of malignancy was evident in a horse that had a locally invasive ameloblastoma of the left hemimandible. Surgical removal of the neoplasm resulted in prompt return of serum calcium and parathyroid hormone concentrations to within reference limits. The tumor contained parathyroid hormone-related protein, as demonstrated by immunohistochemistry and western blot analysis. It is likely that production of this protein by the neoplasm was important in the pathogenesis of the hypercalcemia. The case represented a sporadic form of humoral hypercalcemia of malignancy attributable to an uncommon epithelial neoplasm, and indicated that humoral hypercalcemia of malignancy can develop with neoplasms in horses.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Ohio State University, Columbus 43210.
authors.forename: T J
authors.initials: TJ
authors.lastname: Rosol
authors.forename: L A
authors.initials: LA
authors.lastname: Nagode
authors.forename: J T
authors.initials: JT
authors.lastname: Robertson
authors.forename: B D
authors.initials: BD
authors.lastname: Leeth
authors.forename: C L
authors.initials: CL
authors.lastname: Steinmeyer
authors.forename: C M
authors.initials: CM
authors.lastname: Allen
mesh_terms: D000564:Ameloblastoma / Q000150:complications / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D006734:Horse Diseases / Q000209:etiology* / Q000601:surgery; D006736:Horses; D006934:Hypercalcemia / Q000209:etiology / Q000662:veterinary*; D008297:Male; D008339:Mandibular Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D008341:Mandibular Prosthesis / Q000662:veterinary; D009363:Neoplasm Proteins / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins