title: Expulsion of Trichostrongylus colubriformis by high and low responder guinea-pigs.
abstract: Guinea-pigs with genetically determined susceptibility to infection with Trichostrongylus colubriformis (or low responders) rejected both primary and secondary infections with this parasite more slowly than resistant animals (high responders). Low responders were not protected with a vaccination procedure which was highly effective in outbred animals. The relatively poor protective immune responses that develop in low responder guinea-pigs are evocative of the responses of the natural host to infection with this parasite and suggest that low responder guinea-pigs have potential for the study of T. colubriformis protective antigens and for the development of adjuvants to enhance antiparasitic effector responses in vaccinated hosts.
authors.affiliation: Department of Veterinary Pathology, University of Sydney, NSW, Australia.
authors.forename: T L
authors.initials: TL
authors.lastname: Rothwell
authors.forename: B M
authors.initials: BM
authors.lastname: Wagland
authors.forename: N C
authors.initials: NC
authors.lastname: Sangster
mesh_terms: D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D006168:Guinea Pigs; D007411:Intestinal Diseases, Parasitic / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000276:immunology*; D014253:Trichostrongylosis / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D014254:Trichostrongylus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary