[A comparative evaluation of the efficacy of pharmacotherapeutic agents in hypoxia in the presence of hyperthermia].
In conditions of acute hypoxia in the presence of hyperthermia drugs were shown to exhibit various degrees of protective activity. Antihypoxic action coupled with thermoprotective activity is manifested by beneficial affect on the course of the pathological process. It is quercitrol that proved to be the most effective drug; it is capable of correcting simultaneously the disturbances emerging in different links of the pathological process: effect on the processes of lipid peroxidation and metabolism of arachidonic acid as well as on the activity of enzymes belonging to the monooxigenaze system in the experiment.
Luk'ianchuk
V D
VD
Kozlov
A G
AG
Savchenkova
L V
LV
Lysenko
E A
EA
D000208:Acute Disease; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005334:Fever / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
Sravnitel'naia otsenka éffektivnosti farmakoterapevticheskikh sredstv pri gipoksii na fone gipertermii.