Malignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site.
This study examined time trends and age-period-cohort patterns in the incidence of cutaneous malignant melanoma (CMM) by gender and anatomic site in Connecticut (United States) between 1950 and 1989, using data from the population-based Connecticut Tumor Registry. A total of 8,249 invasive CMM incident cases were included. Cases were grouped into melanomas of the head and neck, upper limb, lower limb, and trunk. Between 1950 and 1989, rates increased substantially for all sites. The largest relative increases occurred in melanoma of the upper limb for both males and females; the largest absolute increase occurred for melanoma of the trunk in males; and the smallest increase occurred in head and neck melanoma in females. Recent trends for time periods 1970-89 among birth cohorts 1930-69 indicated that the rate of increase of CMM is slowing substantially among males, but not among females. Nevertheless, continued overall increases in CMM incidence are likely in Connecticut in the 1990s in both genders, with a decrease in the male-female ratio. The age-period-cohort patterns were significantly different between the genders and among anatomic sites, suggesting different trends in carcinogenic exposures (mainly ultraviolet radiation from the sun) or etiologic distinctions between males and females and among the sites.
Chen
Y T
YT
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034.
Zheng
T
T
Holford
T R
TR
Berwick
M
M
Dubrow
R
R
D000328:Adult; D000367:Age Factors; D000368:Aged; D001132:Arm; D001830:Body Surface Area; D015988:Cohort Effect; D015331:Cohort Studies; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007866:Leg; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D015233:Models, Statistical; D012042:Registries; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology; D013899:Thoracic Neoplasms / Q000453:epidemiology; D013997:Time Factors