title: Investigation of an outbreak of hepatitis A in Irish haemophilia A patients.
abstract: Since 1990, Irish haemophilia A patients have been treated with solvent-detergent(SD)-treated virally inactivated high-purity factor VIII concentrate prepared from plasma from Irish voluntary non-remunerated donors. In 1992, 13 haemophilia A patients developed clinical hepatitis A and a further 17 patients showed serological evidence of recent infection by hepatitis A. All but 3 of these patients had had recent exposure to SD-treated product. A case-control study is underway to determine whether these cases represent transmission through product or environmentally acquired hepatitis A.
authors.affiliation: Blood Transfusion Service Board, St. James's Hospital, Dublin, Ireland.
authors.forename: E
authors.initials: E
authors.lastname: Lawlor
authors.forename: Z
authors.initials: Z
authors.lastname: Johnson
authors.forename: L
authors.initials: L
authors.lastname: Thornton
authors.forename: I
authors.initials: I
authors.lastname: Temperley
mesh_terms: D016913:Blood Component Transfusion / Q000009:adverse effects*; D004196:Disease Outbreaks; D005169:Factor VIII / Q000009:adverse effects; D006467:Hemophilia A / Q000628:therapy*; D006506:Hepatitis A / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male
chemical_list: D005169:Factor VIII