title: Low doses of alpha 2B interferon in the treatment of hairy cell leukemia: results of treatment and mean follow-up at 18 months in 13 patients.
abstract: We treated 13 Hairy Cell Leukemia patients with rIFN a 2b. In case of complete/partial response, the patients were submitted to maintenance treatment, while, in case of minimal/no response, a second induction cycle was administered, followed by a maintenance one. The patients were followed, on an outpatients basis, for 18 months at least, obtaining a 100% overall response rate; one patient had complete response, 7 had partial response, and 5 only minimal response. Six patients (46%) relapsed an average of 13 months after the end of the treatment. The utility of a maintenance therapy is discussed.
authors.affiliation: Istituto di Clinica Medica II, Università di Pavia, IRCCS Policlinico San Matteo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santagati
authors.forename: G
authors.initials: G
authors.lastname: Nastasi
authors.forename: C
authors.initials: C
authors.lastname: Porta
authors.forename: M
authors.initials: M
authors.lastname: Moroni
authors.forename: C
authors.initials: C
authors.lastname: Santagati
authors.forename: I
authors.initials: I
authors.lastname: Casagranda
authors.forename: E
authors.initials: E
authors.lastname: Bobbio-Pallavicini
authors.forename: M F
authors.initials: MF
authors.lastname: Cosimi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins