title: Prophylactic vaccines, risk behavior change, and the probability of eradicating HIV in San Francisco.
abstract: Theory is linked with data to assess the probability of eradicating human immunodeficiency virus (HIV) in San Francisco through the use of prophylactic vaccines. The necessary vaccine efficacy levels and population coverage levels for eradication are quantified. The likely impact of risk behavior changes on vaccination campaigns is assessed. The results show it is unlikely that vaccines will be able to eradicate HIV in San Francisco unless they are combined with considerable reductions in risk behaviors. Furthermore, if risk behavior increases as the result of a vaccination campaign, then vaccination could result in a perverse outcome by increasing the severity of the epidemic.
authors.affiliation: Epidemiology Department, School of Public Health, University of California at Berkeley 94720.
authors.forename: S M
authors.initials: SM
authors.lastname: Blower
authors.forename: A R
authors.initials: AR
authors.lastname: McLean
mesh_terms: D016915:AIDS Vaccines; D000328:Adult; D004196:Disease Outbreaks / Q000517:prevention & control; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control*; D006716:Homosexuality; D006801:Humans; D017589:Immunization Programs; D008297:Male; D011336:Probability; D012309:Risk-Taking; D012495:San Francisco / Q000453:epidemiology
chemical_list: D016915:AIDS Vaccines