Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease.
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Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27710.
D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D000682:Amyloid / Q000502:physiology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology*; D005838:Genotype; D006801:Humans; D007536:Isomerism; D008959:Models, Neurological; D009154:Mutation; D013997:Time Factors
D000682:Amyloid; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E