[Experimental rationale for the use of drugs to increase the resistance of the human body to the combined action of carbon monoxide and hyperthermia].
A group of volunteers was exposed to coaction of carbon dioxide (concentration 300 mg/cu m) and heating microclimate (ambient temperature +50 +/- 2 degrees C, relative humidity 20 +/- 5%), simultaneously they received one of the medicines: placebo, bemitil (0.5 g), bromantane (0.25 g) or bemitil (0.5 g) combined with bromantane (0.25 g). Bromantane (0.25 g) or bemitil (0.5 g) combined with bromantane (0.25 g) were proved to be the most effective method to increase stability of the human body against co-action of carbon dioxide and heating microclimate.
Sedov
A V
AV
Lukicheva
T A
TA
Surovtsev
N A
NA
Akin'shin
A V
AV
Nazarov
L Iu
LIu
Miroshnik
S V
SV
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects*; D002249:Carbon Monoxide Poisoning / Q000517:prevention & control*; D006358:Hot Temperature; D006801:Humans
D000975:Antioxidants; D001562:Benzimidazoles; C049825:bemethyl; D000547:Amantadine; C085955:bromantane
Eksperimental'noe obosnovanie primeneniia farmakologicheskikh preparatov dlia povysheniia ustoĭchivosti organizma cheloveka k sochetannomu vozdeĭstviiu oksida ugleroda i gipertermii.