Possible involvement of central cholinergic system in ameliorating effects of indeloxazine, a cerebral activator, on disturbance of learning behavior in rats.
Effects of indeloxazine, a cerebral activator, on passive avoidance learning by disruption of cholinergic transmission were studied in rats. The shortened latency was prolonged when indeloxazine was administered before training in rats subjected to scopolamine-injection, ethylcholine aziridinium ion (AF64A)-treatment and nucleus basalis magnocellularis (NBM) lesion. Indeloxazine administered immediately after training also showed ameliorating effects on passive avoidance in NBM-lesioned rats. Indeloxazine increased extracellular acetylcholine concentration in the frontal cortex of rats. Indeloxazine possesses facilitatory effects on cerebral function in part due to activation of the central cholinergic system.
Yamamoto
M
M
Applied Pharmacology & Development Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Takahashi
K
K
Ohyama
M
M
Sasamata
M
M
Yatsugi
S
S
Okada
M
M
Endoh
H
H
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001388:Aziridines / Q000494:pharmacology; D001479:Basal Ganglia / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D017551:Microdialysis; D009025:Morpholines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000502:physiology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology
D001388:Aziridines; D009025:Morpholines; D009466:Neuromuscular Blocking Agents; C020852:indeloxazine; C044894:ethylcholine aziridinium; D012601:Scopolamine; D002794:Choline; D000109:Acetylcholine