title: Brain glucose metabolism in Alzheimer's disease.
abstract: In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer's disease showed a marked decrease when compared with nondemented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-dependent decline in the rate of glucose use. These data provide an in vitro correlate for positron emission tomography studies that suggest decreased brain glucose use in Alzheimer's disease.
authors.affiliation: Department of Medicine, NYU Medical Center, NY 10016.
authors.forename: R
authors.initials: R
authors.lastname: Swerdlow
authors.forename: D L
authors.initials: DL
authors.lastname: Marcus
authors.forename: J
authors.initials: J
authors.lastname: Landman
authors.forename: D
authors.initials: D
authors.lastname: Kooby
authors.forename: W
authors.initials: W
authors.lastname: Frey
authors.forename: M L
authors.initials: ML
authors.lastname: Freedman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D013702:Temporal Lobe / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose