Helicobacter pylori: molecular basis for host recognition and bacterial adherence.
The bacterium Helicobacter pylori is tropic for epithelial cells and the mucus layer in the stomach lining, and is associated with the development of gastritis, ulcers and possibly also gastric malignancies. Adherence to the gastric epithelial cells is mediated by fucosylated blood-group antigens associated with blood-group O phenotype, which could explain the higher prevalence of ulcerative disease in individuals with this blood group.
Borén
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Dept of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Normark
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S
Falk
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P
D000017:ABO Blood-Group System / Q000737:chemistry; D000818:Animals; D001422:Bacterial Adhesion / Q000235:genetics; D002240:Carbohydrate Sequence; D005753:Gastric Mucosa / Q000737:chemistry; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000737:chemistry* / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000032:analysis*; D013272:Stomach Diseases / Q000382:microbiology*
D000017:ABO Blood-Group System; D011971:Receptors, Immunologic; C047105:bacterial adhesin receptor