title: [Cryoglobulins in rheumatoid arthritis: exhaustive detection, immunochemical findings and clinical expression].
abstract: Cryoglobulins were measured in 29 patients (24 female, age 53.8 +/- 9.8 years) with rheumatoid arthritis (70% active). The cryoprecipitate was isolated, characterized and quantified. Cryoglobulinemia, always polyclonal or type III, was found in 83% of patients. The most frequent immunochemical isotypes found were IgG and A. Acrocyanosis was found in 50% and Raynaud phenomenon in 32% of patients with cryoglobulinemia. It is concluded that exhaustive detection of cryoglobulinemia in rheumatoid arthritis demonstrated a higher frequency than previously reported an is important for understanding pathogenesis of the disease.
authors.affiliation: Unidad de Fisiopatología, Facultad de Medicina, Universidad de Chile (Campus Occidente), Santiago de Chile.
authors.forename: J
authors.initials: J
authors.lastname: Bekavac
authors.forename: M A
authors.initials: MA
authors.lastname: Varas
authors.forename: A
authors.initials: A
authors.lastname: Ardiles
authors.forename: H
authors.initials: H
authors.lastname: Aris
authors.forename: M A
authors.initials: MA
authors.lastname: Parra
authors.forename: J
authors.initials: J
authors.lastname: Orellana
authors.forename: C
authors.initials: C
authors.lastname: Santa Cruz
authors.forename: M C
authors.initials: MC
authors.lastname: Silva
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications; D001797:Blood Protein Electrophoresis; D003449:Cryoglobulinemia / Q000150:complications; D003450:Cryoglobulins / Q000032:analysis*; D005260:Female; D006801:Humans; D007120:Immunochemistry; D008297:Male; D008875:Middle Aged
chemical_list: D003450:Cryoglobulins
vernacular_title: Crioglobulinas en artritis reumatoide: detección exhaustiva, hallazgos inmunoquímicos y expresion clínica.