Vitamin D prophylaxis during infancy: comparison of the long-term effects of three intermittent doses (15, 5, or 2.5 mg) on 25-hydroxyvitamin D concentrations.
Serum 25-hydroxyvitamin D [25(OH)D], calcium, phosphorus, and alkaline phosphatase activities were measured from birth to 6-9 mo of age in 60 healthy neonates to assess the effectiveness and potential toxicity of three intermittent oral doses of cholecalciferol. Two weeks after a first dose of 15, 5, or 2.5 mg, 25(OH)D concentrations reached 307 +/- 160, 150 +/- 55, and 92 +/- 42 nmol/L, respectively. Prolonged vitamin D overload, up to 6 mo, was found in 50% of the children given 15 mg, but not in the other infants. Serum calcium transiently increased 2 wk after 15 mg but not after the lower doses. Oral doses of 2.5 mg given every 3 mo appear to provide the best protection against vitamin D deficiency and vitamin D overload in high-risk infant populations that are unsuitable for daily vitamin D supplementation.
Zeghoud
F
F
CNRS URA 583-Université Paris V, Hôpital des Enfants-Malades, France.
Ben-Mekhbi
H
H
Djeghri
N
N
Garabédian
M
M
D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D002112:Calcifediol / Q000097:blood*; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D010758:Phosphorus / Q000097:blood; D014808:Vitamin D Deficiency / Q000517:prevention & control*
D002762:Cholecalciferol; D015652:25-Hydroxyvitamin D 2; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002112:Calcifediol; D002118:Calcium