Gadolinium chelate MR contrast agents.
Several Gadolinium chelates are now available or will shortly become available. They differ in being, variously, ionic or non-ionic and in being of higher or lower osmolality. Although they differ in detail of chemical structure, they are all based on the same general principle and all possess the same extracellular distribution pharmacokinetics (Gd BOPTA excepted), typical for their molecular size. In terms of efficacy there is no convincing evidence that any one is clinically superior to the others. As regards reducing osmolality, it is not self evident that, in the recommended and currently widely used dosage regimens, high osmolality presents any real clinical problems. However, if 'high dosage' regimens or dynamic bolus imaging come to be more widely used, then the newer agents may be perceived to have clinical advantages.
Dawson
P
P
Blomley
M
M
D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism; D009994:Osmolar Concentration; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA