Mapping of the X linked form of hyper IgM syndrome (HIGM1)
X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.
Padayachee
M
M
Molecular Genetics Unit, Institute of Child Health, London.
Levinsky
R J
RJ
Kinnon
C
C
Finn
A
A
McKeown
C
C
Feighery
C
C
Notarangelo
L D
LD
Hendriks
R W
RW
Read
A P
AP
Malcolm
S
S
D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D004277:DNA, Single-Stranded / Q000737:chemistry; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics*; D007075:Immunoglobulin M; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010375:Pedigree; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013577:Syndrome; D014960:X Chromosome
D004277:DNA, Single-Stranded; D005819:Genetic Markers; D007075:Immunoglobulin M; D015345:Oligonucleotide Probes