title: [Non-opioids in pain therapy: current perspectives].
abstract: Increasing knowledge of the mechanisms underlying nociceptive processing are making a more rationale approach to pain treatment possible. Recent research has confirmed relevant differences between NSAIDs and the direct analgesic action of several psychotropic drugs. Alpha 2-adrenergic agonists are being clinically tested and have shown considerable analgesic activity in various pain states. Simultaneous treatment of pain with complementary analgesics, i.e. "balanced analgesia", seems to be a logical approach in the light of the close interactions between the different nociceptive pathways. The indications for the use of known analgesics in chronic pain therapy are insufficiently researched.
authors.affiliation: Abteilung für Gastroenterologie, Medizinische Klinik, Inselspital, Universität Bern.
authors.forename: C H
authors.initials: CH
authors.lastname: Wilder-Smith
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002908:Chronic Disease; D004357:Drug Synergism; D006801:Humans; D010146:Pain / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy; D011619:Psychotropic Drugs / Q000627:therapeutic use
chemical_list: D000316:Adrenergic alpha-Agonists; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011619:Psychotropic Drugs
vernacular_title: Nichtopioide in der Schmerztherapie: neue Perspektiven.