[Diagnosis of B-cell lymphoma of lung by kappa-lambda imaging in broncho-alveolar lavage fluid lymphocytes].
We attempted to verify the clonality of proliferating cells in broncho-alveolar lavage fluid (BALF) by using a sophisticated technique known as kappa-lambda imaging. We applied this method to BALF lymphocytes from 3 cases suspected of having primary pulmonary B-cell lymphoma, by transbronchial lung biopsy, and from 2 cases with B-cell lymphoma revealing abnormal shadows. (One was diagnosed as small cell carcinoma, the other mycotic infection). B-cell monoclonality was found in the former 3 cases, but not in the latter 2 cases. We conclude that kappa-lambda imaging in BALF lymphocytes is useful for diagnosing B-cell lymphoma of the lung.
Minemura
K
K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Ichinose
Y
Y
Utsumi
K
K
Kuriyama
Y
Y
Kawanishi
Y
Y
Torii
Y
Y
Yonemaru
M
M
Nakano
M
M
Toyama
K
K
D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008214:Lymphocytes / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains