Theoretical aspects of chiral separation in capillary electrophoresis. III. Application to beta-blockers.
Enantiomers of the beta-blockers propranolol, atenolol, metoprolol, and oxprenolol have been separated by the addition of methyl-beta-cyclodextrin (MeBCD) to the operating buffer. There is an optimum concentration of MeBCD for separation for each of the beta-blockers, the magnitude of which could be ranked by the use of a mathematical model and log P data--an indication of the hydrophobicity of the molecule.
Wren
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SA
Pharmaceutical Department, ICI Pharmaceuticals, Macclesfield, UK.
Rowe
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RC
D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry; D004586:Electrophoresis; D008956:Models, Chemical; D008968:Molecular Conformation; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D003505:Cyclodextrins