title: Interleukin-8 antitumour effect is associated with a local infiltration but not with a systemic activation of T lymphocytes.
abstract: In a model of colon cancer in rats (peritoneal carcinomatosis), IL-8 was found to have a highly reproducible antitumoural effect. During IL-8-induced tumour regression the infiltration of nodules by CD4+ T lymphocytes was enhanced. However, splenic lymphocytes did not proliferate in response to tumour cells in vitro. IL-8 antitumour effect was associated with a local but not with a systemic activation of T lymphocytes.
authors.affiliation: Groupe de Recherche sur les Cancers Digestifs, Faculty of Medicine, Dijon, France.
authors.forename: D
authors.initials: D
authors.lastname: Reisser
authors.forename: P
authors.initials: P
authors.lastname: Lejeune
authors.forename: P
authors.initials: P
authors.lastname: Lagadec
authors.forename: N
authors.initials: N
authors.lastname: Onier
authors.forename: C
authors.initials: C
authors.lastname: Dasilva
authors.forename: I
authors.initials: I
authors.lastname: Lindley
authors.forename: J F
authors.initials: JF
authors.lastname: Jeannin
mesh_terms: D000818:Animals; D016209:Interleukin-8 / Q000494:pharmacology / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects*; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D016209:Interleukin-8