Potentiation of pancuronium and vecuronium neuromuscular blockade by intravenous salbutamol.
Three doses of salbutamol 125 micrograms iv were given, over 3.5 hr, to a 28-yr-old healthy, previously non-asthmatic man during thiopentone-O2/N2O-isoflurane anaesthesia for treatment and prophylaxis of bronchospasm. Force of contraction of the adductor pollicis was measured before and after the last two injections. Initially, the patient was given pancuronium, 5 mg. Salbutamol, 125 micrograms iv, was given when T1 blockade was 45%. Blockade increased to 66% over five minutes and returned to 45% after 18 min. Vecuronium was subsequently used to maintain relaxation. At the end of surgery, salbutamol was followed by an increase in T1 blockade, from 66% to 86%, over five minutes which returned to 66% after ten minutes. It is concluded that intravenous salbutamol potentiates the neuromuscular blocking effect of nondepolarizing muscle relaxants.
Salib
Y
Y
Department of Anaesthesia, Royal Victoria Hospital, Montreal, Quebec, Canada.
Donati
F
F
D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy; D004357:Drug Synergism; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007431:Intraoperative Complications / Q000188:drug therapy; D007530:Isoflurane; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide; D007530:Isoflurane; D010197:Pancuronium; D000420:Albuterol