[Changes in reproductive hormones levels in the treatment of endometrial precancerous lesion with hydroxyprogesterone caproate].
The efficacy of progesterone in treating patients with endometrial carcinoma is well known. The mechanism, however, has not been understood yet. In this paper, 14 cases of precancerous lesion of endometrium were treated with hydroxyprogesterone caproate and a series of hormone determination was analysed before and after treatment. Results showed that LH and LH/FSH were dramatically decreased. (LH P < 0.05, LH/FSH P < 0.01). It is suggested that the mechanism of progesterone is multiphase, one of them is influence on pituitary and selective interference of LH and LH/FSH.
Yang
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Obstetrics and Gynecology Hospital, Shanghai Medical University.
Zhu
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RL
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D016889:Endometrial Neoplasms / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D011230:Precancerous Conditions / Q000097:blood / Q000188:drug therapy*; D045167:Progesterone Congeners / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D006908:Hydroxyprogesterones; D045167:Progesterone Congeners; D000077713:17 alpha-Hydroxyprogesterone Caproate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone