Anxiogenic-like effects of yohimbine and idazoxan in two behavioral situations in mice.
In a light-dark choice situation, the alpha-2 adrenoceptor antagonist idazoxan shows anxiogenic-like effects, which cannot be blocked by the alpha-2 adrenoceptor agonist clonidine, or by the benzodiazepine receptor antagonist Ro 15-1788. In a conditioned conflict situation, both idazoxan and the alpha-2-adrenoceptor yohimbine show anxiogenic-like effects; the effect of idazoxan could not be blocked by clonidine or Ro 15-1788. These data suggest that systems other than alpha-2 adrenoceptors or benzodiazepine receptors must be found to explain these anxiogenic-like properties.
Venault
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P
Génétique, Neurogénétique et Comportement, URA 1294, CNRS, UFR Biomédicale Paris V, France.
Jacquot
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F
Save
E
E
Sara
S
S
Chapouthier
G
G
D000317:Adrenergic alpha-Antagonists / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D003220:Conflict, Psychological; D004146:Dioxanes / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005442:Flumazenil / Q000494:pharmacology; D019329:Idazoxan; D008297:Male; D051379:Mice; D015016:Yohimbine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D015016:Yohimbine; D005442:Flumazenil; D003000:Clonidine; D019329:Idazoxan