title: The effects of brain natriuretic peptide-32 on electroconvulsive shock-induced amenesia in rats. The role of neurotransmitters.
abstract: Partial amnesia was induced in rats by electroconvulsive shock (ECS) immediately after passive avoidance learning. This partial amnesia could be prevented by administering porcine brain natriuretic peptide-32 (pBNP-32) into the lateral brain ventricle. The effects of pretreatment with different receptor blockers (haloperidol, atropine, phenoxybenzamine, propranolol, naloxone, bicuculline and methysergide) on the pBNP-32-induced antiamnesia were investigated. In the doses selected, the blockers had no influence on the ECS-induced amnesia. Haloperidol, atropine, phenoxybenzamine and propranolol blocked the antiamnesic action of the peptide, while naloxone, bicuculline and methysergide were ineffective. These results suggest that pBNP-32 may influence learning processes and that the antiamnesic action of this peptide is mediated by dopaminergic, cholinergic alpha- and beta-adrenergic mediator systems.
authors.affiliation: Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Bidzseranova
authors.forename: J
authors.initials: J
authors.lastname: Varga
authors.forename: G
authors.initials: G
authors.lastname: Telegdy
mesh_terms: D000647:Amnesia / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004597:Electroshock; D007276:Injections, Intraventricular; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors; D013552:Swine
chemical_list: D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D020097:Natriuretic Peptide, Brain; C076910:brain natriuretic peptide, porcine