[Adverse effects in the microcirculatory bed during obsidan treatment of patients with ischemic heart disease and possibilities of their correction by trental].
A total of 82 patients with functional class II angina pectoris who had sustained myocardial infarction and took obsidan, 80-120 mg/day, were studied. Twenty-eight per cent had deteriorated microcirculation by 15% as compared to the baseline levels. Narrowed arterioles, diminished volumetric blood flow in forearm muscles, decreased skin oxygen supply were found at days 3-5. There was higher erythrocyte aggregation, lower deformability, and decreased skin oxygen uptake at days 10-12. A combination of obsidan and trental, 300-400 mg/day, eliminated adverse effects in the microcirculatory bed in the absence of an excessive drop in blood pressure.
Kazlovskiĭ
V I
VI
D000328:Adult; D001160:Arterioles / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy*; D010100:Oxygen / Q000378:metabolism; D010431:Pentoxifylline / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage / Q000009:adverse effects*; D012867:Skin / Q000098:blood supply / Q000378:metabolism
D011433:Propranolol; D010100:Oxygen; D010431:Pentoxifylline
Neblagopriiatnye éffekty v mikrotsirkuliatornom rusle pri lechenii bol'nykh ishemicheskoĭ bolezn'iu serdtsa obzidanom i vozmozhnosti ikh korrektsii trentalom.