title: Severe flares of acne following isotretinoin: large closed comedones (macrocomedones) are a risk factor.
authors.forename: W W
authors.initials: WW
authors.lastname: Bottomley
authors.forename: W J
authors.initials: WJ
authors.lastname: Cunliffe
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D015474:Isotretinoin