The expression of mouse T-cell receptor TCRDV genes in BALB/c spleen.
The rearrangement and expression of six different mouse T-cell receptor TCRDV (V delta) gene subfamilies have been studied in BALB/c mouse spleen. The results show that all the TCRDV gene segments studied can be rearranged and expressed with both the TCRA (alpha) and the TCRD (delta) chain. The apparently restricted and separated V gene repertoire for the TCRD and TCRAT-cell receptor may result from thymus and peripheral selection rather than from selective rearrangement in the DNA level. Several J gene segments show much higher concentration in spleen with TCRDV gene segments, however, these J gene segments do not tend to be located at either end of the J gene cluster.
Wang
K
K
Division of Biology, California Institute of Technology, Pasadena 91125.
Kuo
C L
CL
Koop
B F
BF
Hood
L
L
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000737:chemistry; D015870:Gene Expression; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics*; D013154:Spleen / Q000276:immunology*
D017931:DNA Primers; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta