title: [Influence of the severity of coronary stenosis on the course of left ventricular function in case of subsequent coronary occlusion. Longitudinal coronarographic study].
abstract: In order to evaluate the consequences concerning left ventricular function of the spontaneous occlusion of coronary stenoses, the authors studied the clinical and angiographic characteristics of 30 consecutive patients (25 men, 5 women, mean age: 54) undergoing successive coronary arteriograms showing progression to complete occlusion of the anterior interventricular or right coronary between the two investigations. Two groups of patients were identified: Group I (n = 19) with occlusion of a previously moderate (< or = 50%) stenosis; Group II (n = 11) with occlusion of an initially tight stenosis (> 50%). At the time of the first angiogram, left ventricular ejection fraction (LVEF) was 60 +/- 13% in Group I and 58 +/- 9% in Group II (NS). Times between the two investigations were similar in the two groups (58 +/- 43 months and 54 +/- 57 months, NS). Between the two coronary arteriograms, 7 patients of Group I sustained an infarction as against 3 in Group II (NS). Impairment of LVEF developed in 16 patients of Group I (84%) as against 5 of Group II (45%) (p < 0.005). Global LVEF varied on average by -10.4 +/- 13.3% (p < 0.005) in Group I and -0.1 +/- 9.5% (NS) in Group II. This difference in variation in LVEF between the two groups was significant (p < 0.04). Spontaneous occlusion of moderate coronary stenoses results in certain cases in greater impairment of left ventricular function than the occlusion of tight stenoses. The development of a collateral circulation probably plays a protective role in the second group.
authors.affiliation: Service de Cardiologie B, CHU Nancy-Brabois, Vandceuvre-Les-Nancy.
authors.forename: V
authors.initials: V
authors.lastname: Berder
authors.forename: N
authors.initials: N
authors.lastname: Danchin
authors.forename: Y
authors.initials: Y
authors.lastname: Julliere
authors.forename: P
authors.initials: P
authors.lastname: Buffet
authors.forename: J
authors.initials: J
authors.lastname: Anconina
authors.forename: M
authors.initials: M
authors.lastname: Cuilliere
authors.forename: F
authors.initials: F
authors.lastname: Cherrier
mesh_terms: D000328:Adult; D000368:Aged; D003251:Constriction, Pathologic; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D003328:Coronary Thrombosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology; D012189:Retrospective Studies; D016277:Ventricular Function, Left
vernacular_title: Influence de la sévérité d'une sténose coronaire sur l'évolution de la fonction ventriculaire gauche en cas d'occlusion coronaire ultérieure. Etude coronarographique longitudinale.