Control of megakaryocyte development: from basic data to clinical results.
Megakaryocyte development is a multi-stage cell process which is positively regulated by a number of cytokines and negatively controlled mainly by megakaryocyte-platelet derived molecules. The glycosaminoglycans (GAGs) also play a regulatory role in this process. Understanding of this cell process and its regulation is of both basic and clinical significance in hematology and oncology. Future studies should focus on the pathophysiology of megakaryocytopoietic disorders and the clinical application of growth-regulating factors and GAGs.
Caen
J P
JP
Institut des Vaisseaux et du Sang, Hôpital Lariboisière, Paris, France.
Han
Z C
ZC
D000818:Animals; D002455:Cell Division / Q000502:physiology; D016207:Cytokines / Q000502:physiology / Q000627:therapeutic use; D006025:Glycosaminoglycans / Q000502:physiology; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology* / Q000502:physiology; D010978:Platelet Factor 4 / Q000502:physiology / Q000627:therapeutic use
D016207:Cytokines; D006025:Glycosaminoglycans; D010978:Platelet Factor 4