Effects of angiotensin I of the American bullfrog Rana catesbeiana on amphibian tissues.
1. The effect of bullfrog angiotensin I [Asp1, Val5, Asn9] angiotensin I, (AT I) on short-circuit current (SCC) on isolated toad skin and aorta contractility was examined. 2. AT I increased SCC in toad skin, the effect was partially inhibited by angiotensin-converting enzyme inhibitor (ACEI) teprotide. 3. AT I induced contractile responses in isolated rings of toad aorta. This effect was partially inhibited by captopril and completely blocked by the peptide antagonist [Sar1, Ile8] angiotensin II. 4. Present results indicate that this homologue AT I would act in amphibian tissues by conversion to AT II.
Coviello
A
A
Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.
Soria
M O
MO
Proto
M C
MC
Peral de Bruno
M
M
Berman
D M
DM
Khosla
M C
MC
Bumpus
F M
FM
D000803:Angiotensin I / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001693:Biological Transport, Active / Q000187:drug effects; D002025:Bufonidae; D007537:Isometric Contraction / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011892:Rana catesbeiana; D012869:Skin Absorption / Q000187:drug effects
D000803:Angiotensin I