Pharmacokinetics and penetration into tissue fluid of cefotaxime in bovines.
Concentrations of cefotaxime in serum and tissue fluid were studied in the bovine after intravenous and intramuscular administration at a dosage of 10 mg.kg-1 body weight. Steers implanted subcutaneously with tissue cages were used. After intravenous bolus administration, profiles of mean concentrations in serum over time were described by a two-compartment open model. The rate constant of elimination was 1.4 +/- 0.3 h-1 and the half-life 0.6 +/- 0.1 h. The rate constant of distribution was 11.5 +/- 1.9 h-1, and the half-life was 0.06 +/- 0.01 h. The volume of distribution at steady state was 250.6 +/- 37.3 ml.kg-1. The area under the curve was 31.8 +/- 7.4 micrograms.ml-1.h. The penetration ratio into tissue fluid was 36.5 +/- 15.4%. After intramuscular injection, the half-life was 1.1 +/- 0.3 h, the area under the curve was 27.5 +/- 6.8 micrograms.ml-1.h, and the penetration ratio into tissue fluid was 47.1 +/- 15.8%. The concentrations in tissue fluid after intravenous and intramuscular administration of cefotaxime were elevated during a 6-hour period after administration.
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Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Argentina.
Buschiazzo
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H
Rubio
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M
Quiroga
G
G
de Buschiazzo
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P
D000818:Animals; D001825:Body Fluid Compartments; D002417:Cattle / Q000378:metabolism*; D002439:Cefotaxime / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D014018:Tissue Distribution
D002439:Cefotaxime