title: Characterization and biological activity against Naegleria fowleri of amoebicins produced by Bacillus licheniformis D-13.
abstract: The strain Bacillus licheniformis D-13 produces three hydrophobic peptides (amoebicins d13-A, d13-B, and d13-C) that elicit antiamoebic activity against human-pathogenic and nonpathogenic species of Naegleria and have a broad spectrum of antibacterial activity. The three amoebicins have the same amino acid composition (three Asp, two Glu, two Val, and nine Leu residues) and molecular weight (1,870). Amoebicin d13-B causes lysis of amoebae through disorganization of the cell membrane. It also induces permeability to 86Rb and membrane disruption in asolectin vesicles.
authors.affiliation: Department of Microbiology, Faculty of Sciences, University of Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gálvez
authors.forename: M
authors.initials: M
authors.lastname: Maqueda
authors.forename: P
authors.initials: P
authors.lastname: Cordovilla
authors.forename: M
authors.initials: M
authors.lastname: Martínez-Bueno
authors.forename: M
authors.initials: M
authors.lastname: Lebbadi
authors.forename: E
authors.initials: E
authors.lastname: Valdivia
mesh_terms: D000563:Amebicides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001407:Bacillus / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016848:Naegleria fowleri / Q000187:drug effects*
chemical_list: D000563:Amebicides; D001426:Bacterial Proteins