Stimulation of human neutrophil migration by aurothioglucose and thioglucose.
Migration of human neutrophils was enhanced by aurothioglucose in a concentration-dependent manner. Migration was especially pronounced when the drug was present in the lower compartment of the Boyden chamber, suggesting that the enhancement of migration was chemotactic rather than chemokinetic. Thioglucose followed the same pattern of stimulation as the related gold compound, but the enhancement at the maximally stimulating concentration was less; at higher concentrations thioglucose inhibited random migration.
Elferink
J G
JG
Department of Medical Biochemistry, University of Leiden, The Netherlands.
de Koster
B M
BM
D000634:Aminoquinolines / Q000494:pharmacology; D006051:Aurothioglucose / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004357:Drug Synergism; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors; D006801:Humans; D008751:Methylene Blue / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D013189:SRS-A / Q000037:antagonists & inhibitors
D000634:Aminoquinolines; D013189:SRS-A; D006051:Aurothioglucose; C018399:1-thioglucose; C041715:6-anilino-5,8-quinolinedione; D006162:Guanylate Cyclase; D005947:Glucose; D008751:Methylene Blue