Clearance of LDH-5 from the circulation of inbred mice correlates with binding to macrophages.
Flow cytometry showed that the enzyme lactate dehydrogenase (LDH-5) binds to peritoneal macrophages. The degree of binding appears to be genetically controlled and varies depending on the inbred strain of mouse. The rate at which LDH-5 is cleared from the circulation correlates with the degree of binding to macrophages. These findings suggest that the binding of LDH-5 to macrophages may serve as an in-vitro index of enzyme clearance.
Hayashi
T
T
Laboratory of Veterinary Pathology, Yamaguchi University, Japan.
Notkins
A L
AL
D000818:Animals; D018174:Arterivirus Infections / Q000201:enzymology; D005434:Flow Cytometry; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D007772:Lactate dehydrogenase-elevating virus; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase