Challenges and strategies for AIDS vaccine development.
The major topics covered at this conference included the relevance of the SIV-macaque model for HIV vaccine development, an evaluation of the methods for producing inactivated vaccine, and the possibility of developing attenuated retrovirus vaccines. The possibility that there might be a Graft Versus Host Disease component in human AIDS was discussed, and also the recent discovery that the 'original antigenic sin' phenomenon encountered in influenza vaccines may also be seen in AIDS. It was concluded that results from animal models were encouraging in the quest for an HIV-1 vaccine.
Oxford
J S
JS
London Hospital Medical College, Whitechapel, UK.
Frezza
P
P
Race
E
E
D016915:AIDS Vaccines; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000276:immunology; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic
D016915:AIDS Vaccines; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic