title: [Insulin allergy in type II diabetes: rapid desensitization].
abstract: Eight patients (7 female, 1 male) diagnosed as being allergic to insulin, between the ages of 49 and 68, were evaluated. In seven patients there was a previous history of allergies to other drugs: 4 to penicillin, two to sulfurs and one to nalidixic acid. The clinical manifestations were predominantly systemic: ras, six patients; angioedema, 3 patients; hypotension, three patients; bronchial spasm, 2 patients; generalized eruption, one patient. All 8 patients were subjected to skin tests which were positive, one patient showed a positive local skin reaction and the other seven proved to be positive. All reactions were favorable in all cases which allowed for the continuation of the administration of insulin without adverse reactions.
authors.affiliation: Departamento de inmunología clínica y alergia, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México.
authors.forename: E
authors.initials: E
authors.lastname: Ruíz Barrera
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Cario Cueto
mesh_terms: D000368:Aged; D000818:Animals; D002417:Cattle; D003888:Desensitization, Immunologic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D007428:Intradermal Tests; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood; D008297:Male; D008875:Middle Aged; D013045:Species Specificity; D013997:Time Factors
chemical_list: D007328:Insulin; D008263:Macrophage Migration-Inhibitory Factors
vernacular_title: Alergia a la insulina en diabetes tipo II: desensibilización rápida.