Preparation and clinical evaluation of technetium-99m dimercaptosuccinic acid for tumour scintigraphy.
We describe a simple method of pentavalent technetium-99m dimercaptosuccinic acid [99mTc(V)-DMSA] preparation for the imaging of medullary carcinoma of the thyroid using commercially available kits. 99mTc(V)-DMSA is available at high pH (approximately 7.5) by adding NaHCO3 solution in the presence of a small amount of reducing agent (SnCl2). On the other hand, trivalent 99mTc-DMSA [99mTc(III)-DMSA] can be obtained at low pH (below 3) in the presence of an excess amount of reducing agent. In the clinical evaluation of a patient with a medullary carcinoma of the thyroid, only 99mTc(V)-DMSA revealed an area of intense accumulation.
Hirano
T
T
Department of Nuclear Medicine, Gunma University, School of Medicine, Japan.
Tomiyoshi
K
K
Zhang
Y J
YJ
Ishida
T
T
Inoue
T
T
Endo
K
K
D019797:3-Iodobenzylguanidine; D000368:Aged; D018276:Carcinoma, Medullary / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013793:Thallium; D013794:Thallium Radioisotopes; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D013794:Thallium Radioisotopes; D019797:3-Iodobenzylguanidine; C027549:thallium chloride; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013793:Thallium; D004113:Succimer