title: Effects of cholecystokinin tetrapeptide and sulfated cholecystokinin octapeptide in rat models of anxiety.
abstract: The effects of the acutely administered cholecystokinin (CCK) agonists CCK tetrapeptide (BOC-CCK-4) and sulfated CCK octapeptide (CCK-8S) were examined in four animal models of anxiety in rats. In the elevated plus maze, BOC-CCK-4 reduced the time spent in the open arms and the number of entries into the open arms. BOC-CCK-4 but not the anorectic acting CCK-8S increased the suppression of feeding in a conflict paradigm based on novelty suppressed feeding in hungry rats. In the two-compartment black-and-white box, BOC-CCK-4 decreased the time spent and locomotor activity in the white compartment. In the ultrasound vocalization test, using rat pups separated from the mother, BOC-CCK-4 increased the number of distress calls. No evidence was found for inducing anxiety-like behaviour by CCK-8S.
authors.affiliation: Institute of Pharmacology and Toxicology, Medical Faculty (Charité), Humboldt University at Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Rex
authors.forename: T
authors.initials: T
authors.lastname: Barth
authors.forename: J P
authors.initials: JP
authors.lastname: Voigt
authors.forename: A M
authors.initials: AM
authors.lastname: Domeney
authors.forename: H
authors.initials: H
authors.lastname: Fink
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000523:psychology; D001010:Anxiety, Separation / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D003220:Conflict, Psychological; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000494:pharmacology*; D013758:Tetragastrin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D013758:Tetragastrin; C063051:butyloxycarbonyl-tryptophyl-methionyl-aspartyl-phenylalaninamide; D012844:Sincalide