[A study of intercellular adhesion molecule-1 (ICAM-1) in cervical cancer].
Intercellular adhesion molecule-1(ICAM-1), one of the adhesion molecules, plays an important role in target-cell lysis by immune cells. In this study we examined the expression of ICAM-1 in 15 cases of cervical cancer. We also examined ICAM-1 expression on cervical cancer cell lines in response to cytokines. Immunohistochemistry revealed expression (4 positive among 15 cases) of ICAM-1 in cervical cancer. Furthermore, the expression of ICAM-1 on cervical cancer was correlated with the degree of mononuclear cell infiltration, bearing CD3. On the other hand, the expression of ICAM-1 was not correlated with Class I or Class II antigens in cervical cancer. The expression of ICAM-1 on cervical cancer cell lines was augmented by in vitro treatment with interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. These results suggest that the expression of ICAM-1 on cervical cancer might be modified by cytokines, and ICAM-1 expression on cervical cancer might augment the host immune reaction. So it will be possible to use cytokines in immunotherapy.
Okamoto
Y
Y
Department of Obstetrics and Gynecology, Osaka Medical College.
Tsurunaga
T
T
Ueda
M
M
Yamada
T
T
Ueki
M
M
Sugimoto
O
O
D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000502:physiology; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma / Q000494:pharmacology; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000473:pathology
D015815:Cell Adhesion Molecules; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma