title: The sequence organization of the long arm pseudoautosomal region of the human sex chromosomes.
abstract: We have analysed the sequence organization of the pseudoautosomal region at the telomeres of the long arms of the human sex chromosomes and shown that it is 320 kb long. A LINE sequence is present on both the X and Y chromosomes immediately adjacent to the breakpoint in homology suggesting that the homology arose as a result of an ectopic recombination event mediated by LINE sequences originally present in non-homologous stretches of X and Y chromosomal DNA. This led to the translocation of sequences from the X chromosome telomere onto the Y chromosome and created a new pseudoautosomal region.
authors.affiliation: Department of Biochemistry, University of Oxford, UK.
authors.forename: K
authors.initials: K
authors.lastname: Kvaløy
authors.forename: F
authors.initials: F
authors.lastname: Galvagni
authors.forename: W R
authors.initials: WR
authors.lastname: Brown
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D005260:Female; D005785:Gene Conversion; D006801:Humans; D008297:Male; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome