[Fibrinolytic and thrombolytic properties of the drug morikrase].
Fibrinolytic and thrombolytic properties of morikrase, a complex of proteinases obtained from hepatopancreatic tissues of king crab (Paralithodes camtschatica), were studied in vivo and in vitro. High fibrinolytic activity and dose-dependent activating properties were detected on standard and heated fibrin plates. The preparation maintained its properties during long-term storage at 4 degrees and 22 degrees C. The thrombolytic activity of the drug, affecting the preformed thrombus, was observed both in vitro and in vivo, in rats with experimental thrombosis. Two-phase alteration of the fibrinolytic system and moderate hypocoagulation were found after intravenous administration of morikrase.
Andreenko
G V
GV
Liutova
L V
LV
Rudenskaia
G N
GN
Karabasova
M A
MA
Kupenko
O G
OG
Isaev
V A
VA
D000595:Amino Acid Sequence; D000818:Animals; D010450:Endopeptidases / Q000378:metabolism / Q000494:pharmacology*; D004795:Enzyme Stability; D005343:Fibrinolytic Agents / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000378:metabolism / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology; D051381:Rats
D005343:Fibrinolytic Agents; D009097:Multienzyme Complexes; D010450:Endopeptidases; C089174:morikrase
Fibrinoliticheskie i tromboliticheskie svoĭstva preparata morikrazy.