[Lipidemic alterations in a child with acute lymphoblastic leukemia in treatment with L-aspariginase].
The case of a child treated for Acute Lymphoblastic Leukemia (LLA) with high-dose L-asparaginase, (HD L-ase) presented alteration who of lipidemic values (rise of total cholesterol and triglyceride values) without toxicity is described. This finding has previously been reported in only a few patients. Parameters normalized with dietetic regimen. The authors underline the importance of the control, in patient during HD L-ase treatment of lipidic values too, especially when parents also have similar alterations.
Barisone
E
E
Clinica Pediatrica II, Istituto di Discipline Pediatriche, Università degli Studi di Torino.
Savino
F
F
Saitta
M
M
Vivenza
C
C
Oderda
S
S
Miniero
R
R
Madon
E
E
D001215:Asparaginase / Q000008:administration & dosage* / Q000627:therapeutic use*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000201:enzymology; D050356:Lipid Metabolism; D008429:Maternal Welfare; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy*
D001215:Asparaginase
Alterazioni lipidiche in una bambina affetta da leucemia linfoblastica acuta (LLA) in trattamento con L-asparaginasi.