Infrequent chromosome allele loss in fibrolamellar carcinoma.
As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses.
Ding
S F
SF
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Delhanty
J D
JD
Bowles
L
L
Dooley
J S
JS
Wood
C B
CB
Habib
N A
NA
D000328:Adult; D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002872:Chromosome Deletion; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D004273:DNA, Neoplasm