High cooperativity of hemoglobin-oxygen binding in embryonic rabbit blood.
In rabbit embryos, 13 or 14 days after conception, the oxygen equilibrium curve climbs steeply above about 50% saturation. The value of the Hill coefficient (nH) in the upper part of the curve is significantly greater than 4, indicating aggregation of tetramers or interaction between adjacent tetramers. This is the first time this has been described in blood of a normal eutherian (placental) mammal.
Holland
R A
RA
School of Physiology & Pharmacology, University of New South Wales, Kensington, Sydney, Australia.
Calvert
S J
SJ
D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy; D011487:Protein Conformation; D011817:Rabbits
D006454:Hemoglobins; D010100:Oxygen