Secretion of a fibronectin-like substance from head and neck carcinomas.
The secretion of a fibronectin-like substance in culture supernatants of cell lines of head and neck squamous cell carcinomas was observed. Culture supernatants of some tumor cells had a high cell-attachment activity. Enzyme-linked immunosorbent assay with an antifibronectin antibody showed that the supernatant with cell attachment activity contained fibronectin. Furthermore, the cell attachment activity was clearly inhibited by the addition of a monoclonal antibody to fibronectin. These findings strongly suggest that the fibronectin produced by cancer cells is one of the potent mediators of the cell attachment.
Sakumoto
M
M
Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Kanagawa, Japan.
Tsukuda
M
M
Mochimatsu
I
I
Yago
T
T
Kokatsu
T
T
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002448:Cell Adhesion; D005353:Fibronectins / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D014407:Tumor Cells, Cultured
D005353:Fibronectins