[The role of natural killer cell activity in the pathogenesis of chronic myeloproliferative diseases].
The study of natural killers' (NK) activity was carried out in 114 patients with myelo-proliferative diseases (MPD). Fall of NK-activity was found in all patients. Chronic myeloleukemia was associated with the most considerable decrease of blood leukocytes' cytotoxicity. Patents with gross tumorous mass and exacerbation of leukemic process revealed reduced NK activity as compared to those with low mass of tumor and stable leukemia.
Guseva
S A
SA
D002908:Chronic Disease; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology / Q000276:immunology; D009196:Myeloproliferative Disorders / Q000209:etiology* / Q000276:immunology; D011087:Polycythemia Vera / Q000209:etiology / Q000276:immunology; D055728:Primary Myelofibrosis / Q000209:etiology / Q000276:immunology
Rol' aktivnosti estestvennykh killernykh kletok v patogeneze khronicheskikh mieloproliferativnykh zabolevaniĭ.