Short term effects of acute inhibition of the angiotensin-converting enzyme on the renin-angiotensin system and plasma atrial natriuretic peptide in healthy dogs fed a low-sodium diet versus a normal-sodium diet.
The purpose of the present study was to quantify some of the short term responses of the renin-angiotensin system (RAS) to a recommended dosage of the angiotensin-converting enzyme inhibitor enalapril in clinically healthy dogs fed a normal-sodium and a low-sodium diet. A single dose of enalapril (0.5 mg/kg PO) was given to eight clinically healthy male Beagle dogs after a period where the dogs were fed a normal-sodium diet and low-sodium diet, respectively. Serum angiotensin-converting enzyme activity (ACE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma atrial natriuretic peptide (ANP) concentration were measured during the following twenty-four hour period. The data indicate that enalapril induced a potent blockade of the renin-angiotensin system (RAS) for at least twenty-four hour. Specifically, enalapril during low-sodium diet elicited an exaggerated increase in PRA and a diminished decrease in ACE and ANP when compared to the results of the drug during normal-sodium diet. Long term controlled studies of enalapril in dogs with congestive heart failure (CHF) are warranted in order to determine the duration of action and optimal dose of enalapril.
Koch
J
J
Small Animal Hospital, Department of Clinical Studies, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Pedersen
H D
HD
Jensen
A L
AL
Flagstad
A
A
Poulsen
K
K
Bie
P
P
D000450:Aldosterone / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004039:Diet, Sodium-Restricted / Q000009:adverse effects*; D004285:Dogs / Q000502:physiology*; D004656:Enalapril / Q000494:pharmacology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000450:Aldosterone; D004656:Enalapril; D009320:Atrial Natriuretic Factor; D007703:Peptidyl-Dipeptidase A; D012083:Renin