Tacalcitol ointment for psoriasis.
Transdermal absorption of tacalcitol from the ointment containing 2 micrograms/g was studied using hairless rat and human skin. In the animal experiments, a non-negligible amount of tacalcitol was absorbed transdermally, whereas in the case of human skin, this compound was hardly absorbed at all. A placebo-controlled double-blind right/left comparison confirmed that this ointment is effective and safe for the treatment of psoriasis.
Nishimura
M
M
Department of Dermatology, Saga Prefect, Hospital Kouseikan, Japan.
Makino
Y
Y
Matugi
H
H
D000818:Animals; D004100:Dihydroxycholecalciferols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004311:Double-Blind Method; D006801:Humans; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
D004100:Dihydroxycholecalciferols; D009824:Ointments; C023850:1 alpha,24-dihydroxyvitamin D3