[Role of prostaglandins in the regulation of intrapulmonary shunting during lung surgery].
Pulmonary and systemic hemodynamics, gas exchange, intrapulmonary shunting (IS), arterial and mixed venous blood levels of prostaglandin-like substances (PGE + A and PGF2a) have been studied in 63 patients during lung surgery under multicomponent anesthesia with halothane and fentanyl. It has been established that 17% of patients developed intraoperatively arterial hypoxemia associated with IS increase. IS changes resulted from local active release of prostaglandins, mostly E + A group ones, possessing a vasodilating effect in pulmonary vessels.
Nazyrova
L A
LA
Beletskaia
N V
NV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D005283:Fentanyl; D006221:Halothane; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000601:surgery*; D008171:Lung Diseases / Q000601:surgery; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology*
D011453:Prostaglandins; D005283:Fentanyl; D006221:Halothane
Rol' prostaglandinov v reguliatsii vnutrilegochnogo shuntirovaniia v khirurgii legkikh.