Expression of MHC class I antigen in Morris rat hepatoma and normal liver.
Expression of major histocompatibility complex (MHC) class I antigen in Morris rat hepatoma 7777 and normal rat liver tissues was studied by immunohistochemical techniques, Western blot and radiobinding assay. It was found that hepatoma tissue displayed a pattern of enhanced MHC class I antigen expression compared with normal liver. This phenomenon may represent an uncommon pattern of MHC class I antigen expression of liver tumor. The influence of enhanced MHC class I antigen expression on the development and spread of tumors as well as the possible mechanisms of this enhancement are discussed.
Wang
D
D
Department of Biochemistry, Faculty of Medicine, National University of Singapore.
Yang
E
E
Mach
P
P
Cheng
L Y
LY
D000818:Animals; D015153:Blotting, Western; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry* / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000737:chemistry* / Q000276:immunology*; D011869:Radioligand Assay; D051381:Rats; D011915:Rats, Inbred BUF
D015395:Histocompatibility Antigens Class I