[Ripening effect of mylis and tiluoan on the uterine cervix in pregnant rats].
Effect of Mylis and Tiluoan on cervical ripening and blood levels of estradiol and progesterone of pregnant rats were studied. Dehydroepiandrosterone (DHA) is the main component in both of the drugs. Pregnant rats groups were given the drugs on the 19th day of gestation at dosage of 10, 20 and 40 mg/kg respectively. The results indicated that both drugs at different dose were able to significantly decrease the cervical extensibility, to dilate the cervical OS, increase the cervical wet weight, and elevate the blood estradiol level, lower the progesterone concentration. It indicated that DHA enhances estradiol synthesis and suppresses progesterone secretion.
Shi
S Q
SQ
National Research Institute for Family Planning, Beijing.
Zuo
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Z
Zuo
X C
XC
D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol / Q000097:blood; D005260:Female; D007745:Labor Onset / Q000097:blood; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley
D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate