title: HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens.
abstract: In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR1 was found in subjects who were responsive to Fel d I compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1.9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phl p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.
authors.affiliation: Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Young
authors.forename: J W
authors.initials: JW
authors.lastname: Dekker
authors.forename: B P
authors.initials: BP
authors.lastname: Wordsworth
authors.forename: C
authors.initials: C
authors.lastname: Schou
authors.forename: K D
authors.initials: KD
authors.lastname: Pile
authors.forename: F
authors.initials: F
authors.lastname: Matthiesen
authors.forename: W M
authors.initials: WM
authors.lastname: Rosenberg
authors.forename: J I
authors.initials: JI
authors.lastname: Bell
authors.forename: J M
authors.initials: JM
authors.lastname: Hopkin
authors.forename: W O
authors.initials: WO
authors.lastname: Cookson
mesh_terms: D000483:Alleles; D000485:Allergens / Q000276:immunology*; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D016133:Polymerase Chain Reaction
chemical_list: D000485:Allergens; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D007073:Immunoglobulin E