title: Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.
abstract: A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
authors.affiliation: Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: R
authors.initials: R
authors.lastname: Wooster
authors.forename: S L
authors.initials: SL
authors.lastname: Neuhausen
authors.forename: J
authors.initials: J
authors.lastname: Mangion
authors.forename: Y
authors.initials: Y
authors.lastname: Quirk
authors.forename: D
authors.initials: D
authors.lastname: Ford
authors.forename: N
authors.initials: N
authors.lastname: Collins
authors.forename: K
authors.initials: K
authors.lastname: Nguyen
authors.forename: S
authors.initials: S
authors.lastname: Seal
authors.forename: T
authors.initials: T
authors.lastname: Tran
authors.forename: D
authors.initials: D
authors.lastname: Averill
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D005260:Female; D016161:Genes, Retinoblastoma; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D010641:Phenotype
chemical_list: D005819:Genetic Markers