title: Flecainide-induced JT prolongation, T wave inversion and ventricular tachycardia during treatment for symptomatic atrial fibrillation.
abstract: Two hours after taking 100 mg of flecainide, a patient developed gastrointestinal complaints, dizziness and shortness of breath. The ECG demonstrated novel prolonged JT interval with negative T wave in the precordial leads. During admission, several attacks of non-sustained ventricular tachycardia occurred. The plasma drug concentration was 814 mg/l. Although the tachycardia was non-sustained, cardiovascular collapse developed. Serum electrolytes were normal and myocardial infarction was excluded. The patient is now free of symptoms without medications.
authors.affiliation: Department of Cardiology, Streekziekenhuis Midden-Twente, Hengelo, The Netherlands.
authors.forename: S A
authors.initials: SA
authors.lastname: Said
authors.forename: S T
authors.initials: ST
authors.lastname: Somer
authors.forename: H A
authors.initials: HA
authors.lastname: Oude Luttikhuis
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000628:therapy*; D004554:Electric Countershock; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000009:adverse effects* / Q000627:therapeutic use; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D017180:Tachycardia, Ventricular / Q000139:chemically induced*
chemical_list: D005424:Flecainide