The effects of tannic acid on serum and liver lipids of RAIF and RICO rats fed on high fat diet.
1. Male genetically hypercholesterolemic (RICO) and normocholesterolemic (RAIF) rats were divided into four groups and each group was fed one of the following diets for 10 weeks: a standard diet (STD); STD supplemented with tannic acid (STD + T); a high fat diet (HFD) and a high fat diet with tannic acid (HFD + T). 2. The RAIF and RICO rats when fed on HFD + T showed beneficial changes in serum lipids compared to the rats fed HFD. The lipid parameters between the groups fed STD and STD + T in both strains were unchanged. 3. The possible modes of hypocholesterolemic action of tannic acid in these rats is discussed.
Yugarani
T
T
Department of Biochemistry, Faculty of Medicine, National University of Singapore.
Tan
B K
BK
Das
N P
NP
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000097:blood / Q000187:drug effects; D006938:Hyperlipoproteinemia Type II / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D012016:Reference Values
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D047348:Hydrolyzable Tannins; D008055:Lipids; D006903:Hydroxymethylglutaryl CoA Reductases