Severe episode of high fever with rash, lymphadenopathy, neutropenia, and eosinophilia after minocycline therapy for acne.
Minocycline is a tetracycline agent frequently used for acne therapy. It has a few rare but severe side effects that are not widely known but should be recognized early as drug related. These include acute hepatitis and liver failure; a Löffler-like syndrome with pulmonary infiltrates, wheezing, fever, and eosinophilia; skin eruptions, eosinophilic cellulitis, and pustular folliculitis with eosinophilia; and a lupuslike syndrome. Side effects that are better known and recognized include photosensitization, skin exanthema with pruritus, and pseudotumor cerebri.
Kaufmann
D
D
Department of Internal Medicine, University Hospital, Bern, Switzerland.
Pichler
W
W
Beer
J H
JH
D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008206:Lymphatic Diseases / Q000139:chemically induced*; D008911:Minocycline / Q000009:adverse effects*; D009503:Neutropenia / Q000139:chemically induced*
D008911:Minocycline