[Quantitative study on the effect of oncostatic toxicity on murine fertility].
Oncostatics such as Cisplatin (CDDP), Adriamycin (ADM), and Cyclophosphamide (CPM) were administered to 6-week-old C57BL/6 female mice to destroy 50% (ED50: ED50 treated group) or 80% (ED80: ED80 treated group) of their primordial follicles. Thereafter, they were mated at the age of 11 weeks (group I), and 19 weeks (group II) to study the quantitative oncostatic toxicity to murine fertility. Group I: The maternal body weight before pregnancy in the oncostatics treated group was smaller than the control. The fertile ratios of ED50 (61%) and ED80 (50%) were smaller than that of the control (83%). Six fetal abnormalities (23.2 +/- 10.4%) in ADM.ED50, and 3 (8.1 +/- 2.7%) in CPM.ED80 were regarded as significant (p < 0.05). Group II: Maternal body weight before delivery in CDDP.ED80, ADM.ED50 and ADM.ED80 was less than the control (p < 0.05). The fertile ratios for ED50 (61%) and for ED80 (39%) were smaller than the control (83%). The fetal number for ED80 (7.0 +/- 0.6) was smaller than the control (8.2 +/- 1.1). Fetal birth weight for ED80 and ADM.ED80 was less than the control (p < 0.05). The frequency of IUFD in CDDP.ED50 (9.7 +/- 3.3%) was higher than the control (4.0 +/- 3.6%). In group I, the growing follicles damaged with oncostatics decreased the number of fertile mice and increased IUFD and abnormalities. In group II, the primordial follicles destroyed or decreased by oncostatics led to a decrease in the number of fetuses and birth weight.
Shima
Y
Y
Department of Obstetrics and Gynecology, Tokyo Women's Medical College.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003520:Cyclophosphamide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin