Induction of tolerance in mature peripheral T cells.
Self tolerance can not only be established during T cell maturation in the thymus but also in mature peripheral T cells by several extrathymic mechanisms. This has been found by analysing anti-Kb T cell receptor transgenic mice which expressed this transplantation antigen as a second transgene product in various extrathymic tissues. The described observations could lead to new strategies to improve immunosuppression in allograft transplantation.
Arnold
B
B
German Cancer Research Center, Heidelberg.
Schönrich
G
G
Hämmerling
G J
GJ
D000818:Animals; D002460:Cell Line; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics; D006183:H-2 Antigens / Q000235:genetics; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D005904:Glial Fibrillary Acidic Protein; D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D011948:Receptors, Antigen, T-Cell