title: Creutzfeldt-Jakob disease and blood transfusion.
abstract: Epidemiological surveillance of Creutzfeldt-Jakob disease (CJD) in the UK identified 21 patients who had received a blood transfusion and 29 who had donated blood, out of a total of 202 definite and probable cases. This frequency of blood transfusion or donation did not differ from that in age and sex matched controls, and the clinical features in patients with a history of blood transfusion were similar to those of classical CJD and clearly distinct from CJD in recipients of human growth hormone. This evidence does not suggest that blood transfusion is a major risk factor for CJD.
authors.affiliation: Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
authors.forename: T F
authors.initials: TF
authors.lastname: Esmonde
authors.forename: R G
authors.initials: RG
authors.lastname: Will
authors.forename: J M
authors.initials: JM
authors.lastname: Slattery
authors.forename: R
authors.initials: R
authors.lastname: Knight
authors.forename: R
authors.initials: R
authors.lastname: Harries-Jones
authors.forename: R
authors.initials: R
authors.lastname: de Silva
authors.forename: W B
authors.initials: WB
authors.lastname: Matthews
mesh_terms: D001782:Blood Donors / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000209:etiology / Q000635:transmission; D003644:Death Certificates; D004739:England / Q000453:epidemiology; D013006:Growth Hormone / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D065227:Transfusion Reaction; D014852:Wales / Q000453:epidemiology
chemical_list: D013006:Growth Hormone