Inhibition of human red blood cell N-acetyltransferase.
Acetanilide and derivatives of benzoic acid, benzamide, salicylic acid, and salicylamide were tested as inhibitors of p-aminobenzoic acid N-acetyltransferase partially purified from peripheral blood of three rapid and two slow dapsone acetylator human volunteers. The 50% inhibition point of these compounds does not provide a kinetic basis for differentiating the rapid and slow dapsone acetylator phenotypes.
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Department of Pharmacology, University of Michigan, Ann Arbor 48109-0626.
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D010129:4-Aminobenzoic Acid / Q000378:metabolism; D000083:Acetanilides / Q000494:pharmacology; D001191:Arylamine N-Acetyltransferase / Q000037:antagonists & inhibitors* / Q000097:blood; D001549:Benzamides / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D012457:Salicylamides / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology
D000083:Acetanilides; D001549:Benzamides; D001565:Benzoates; D012457:Salicylamides; D012459:Salicylates; D001191:Arylamine N-Acetyltransferase; D010129:4-Aminobenzoic Acid