title: Tyr-MIF-1 precipitates abstinence syndrome in morphine-dependent rats.
abstract: The endogenous neuropeptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide) has been shown to counteract various opiate actions. In the current study, third ventricular injection of 35 micrograms Tyr-MIF-1 protected by the enzyme inhibitor bestatin precipitated an abstinence syndrome in morphine-dependent rats, but not in opiate-naive rats. The results raise the possibility that Tyr-MIF-1 might participate in opiate dependence and opiate abstinence syndrome.
authors.affiliation: University of Houston-Clear Lake, TX 77058.
authors.forename: D R
authors.initials: DR
authors.lastname: Malin
authors.forename: J E
authors.initials: JE
authors.lastname: Zadina
authors.forename: J R
authors.initials: JR
authors.lastname: Lake
authors.forename: R B
authors.initials: RB
authors.lastname: Rogillio
authors.forename: J E
authors.initials: JE
authors.lastname: Leyva
authors.forename: T M
authors.initials: TM
authors.lastname: Benson
authors.forename: L S
authors.initials: LS
authors.lastname: Corriere
authors.forename: B P
authors.initials: BP
authors.lastname: Handunge
authors.forename: A J
authors.initials: AJ
authors.lastname: Kastin
mesh_terms: D000818:Animals; D006801:Humans; D007231:Infant, Newborn; D009075:MSH Release-Inhibiting Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D009021:Morphine Dependence; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
chemical_list: D009020:Morphine; C036930:tyrosyl-prolyl-leucyl-glycinamide; D009075:MSH Release-Inhibiting Hormone