title: Identification of a cross-reactive allergen (presumably tropomyosin) in shrimp, mite and insects.
abstract: A monoclonal antibody to Dermatophagoides pteronyssinus is described that cross-reacts with an IgE-binding antigen present in insects, Crustacea (e.g. shrimp) and other invertebrates. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gel filtration and immunofluorescence it was shown that this monoclonal antibody presumably recognizes tropomyosin. Tropomyosin was shown to be involved in cross-reactivity between mite, shrimp and insects in shrimp-allergic patients.
authors.affiliation: Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam.
authors.forename: A M
authors.initials: AM
authors.lastname: Witteman
authors.forename: J H
authors.initials: JH
authors.lastname: Akkerdaas
authors.forename: J
authors.initials: J
authors.lastname: van Leeuwen
authors.forename: J S
authors.initials: JS
authors.lastname: van der Zee
authors.forename: R C
authors.initials: RC
authors.lastname: Aalberse
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D003429:Cross Reactions; D033364:Decapoda / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007313:Insecta / Q000276:immunology*; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test; D014335:Tropomyosin / Q000276:immunology*
chemical_list: D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D014335:Tropomyosin; C026408:anti-IgE antibodies; D007073:Immunoglobulin E