title: Affected sibs with fragile X syndrome exhibit an age-dependent decrease in the size of the fragile X full mutation.
abstract: The sizes of the fragile X mutation in 33 sib pairs affected with fragile X syndrome were determined by Southern blot analysis. An age-dependent decrease in the size of the mutation was found, suggesting positive selection of blood cells carrying small mutations during life or maternal imprinting.
authors.affiliation: Centre d'Etudes de Biologie Prénatale, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Mornet
authors.forename: M
authors.initials: M
authors.lastname: Jokic
authors.forename: A
authors.initials: A
authors.lastname: Bogyo
authors.forename: I
authors.initials: I
authors.lastname: Tejada
authors.forename: C
authors.initials: C
authors.lastname: Deluchat
authors.forename: J
authors.initials: J
authors.lastname: Boué
authors.forename: A
authors.initials: A
authors.lastname: Boué
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001482:Base Composition; D015139:Blotting, Southern; D002648:Child; D004247:DNA / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004247:DNA