Sorption of isosorbide dinitrate to central venous catheters.
As several studies demonstrated the sorption of isosorbide dinitrate (ISDN) to intravenous delivery systems, a study on the sorption of ISDN to several central venous catheters was performed. Fourteen different catheters were perfused during a 2 h period, under simulated infusion conditions, with ISDN (250 micrograms mL-1) in 0.9% (w/v) sodium chloride. The drug loss to a polyethylene and a silicone catheter was 0.2 and 6.1%, respectively. The sorption to a polyvinylchloride heparin-coated thermodilution catheter was 1-6.9% depending on the length of the catheter. The drug loss to polyurethane catheters of different composition varied between 3.8 and 28.9%. For polyurethane catheters composed of cycloaliphatic polyurethanes an inverse relation was shown between Shore A hardness and sorption.
De Muynck
C
C
Laboratory of Pharmaceutical Technology, University of Ghent, Belgium.
Vandenbossche
G M
GM
Colardyn
F
F
Remon
J P
JP
D000327:Adsorption; D002405:Catheterization, Central Venous / Q000295:instrumentation*; D002851:Chromatography, High Pressure Liquid; D007548:Isosorbide Dinitrate / Q000737:chemistry*; D011095:Polyethylenes; D011140:Polyurethanes; D011143:Polyvinyl Chloride; D012826:Silicone Elastomers; D013056:Spectrophotometry, Ultraviolet
D011095:Polyethylenes; D011140:Polyurethanes; D012826:Silicone Elastomers; D011143:Polyvinyl Chloride; D007548:Isosorbide Dinitrate