[Changes in parameters of lipid metabolism and anti-oxidative potentials in elderly hyperlipoproteinemic patients treated with omega-3 fatty acids].
Omega-3-fatty acids play a protective role in the prevention of CHD, however, they can have a negative influence on LDL-oxidation and aging processes by the formation of peroxides. In 56 patients with HLP (40 with mixed HLP and hypertriglyceridemia, respectively, and 16 with hypercholesterolemia) changes in the lipid state and in the parameters of the antioxidative potential before and after a 4-week-olive-oil phase and after 8, 20, and 32 weeks intakes of salmon-oil capsules were determined. The treatment with salmon-oil capsules were determined. The treatment with salmon oil led to a decrease of triglycerides in patients with hypertriglyceridemia and to an increase of cholesterol in hypercholesterolemia. Following the increase of malondialdehyde as measure of the lipid peroxidation a substitution of antioxidants, like vitamin E and vitamin C, seems to be useful. Further investigations are necessary before wide use of fish-oil capsules, not least to avoid side-effects.
Reuter
W
W
Abteilung Gerontologie/Stoffwechsel, Universität Leipzig.
Vorberg
B
B
Sauer
I
I
Krumpolt
C
C
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000009:adverse effects; D005609:Free Radicals; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D006951:Hyperlipoproteinemias / Q000097:blood / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D005609:Free Radicals; D008055:Lipids; D017382:Reactive Oxygen Species; D014280:Triglycerides; C030341:salmon oil; D002784:Cholesterol
Untersuchungen zum Verhalten von Parametern des Lipidmetabolismus und des antioxidativen Potentials bei älteren HLP-Patienten unter Omega-3-Fettsäuren-Therapie.