HLA-ABC antigens in supraglottic cancer patients and their relationship with incidence and survival.
The frequency of HLA-ABC antigens in the total of 153 cases of supraglottic cancer of the larynx and in 118 and 37 patients from this group after 3 years and 5 or more years of survival respectively, was analysed. No significant differencies in the phenotype frequency class I HLA antigens in these patients were found, as compared with the frequency of of HLA, antigens in the healthy control population. The incidence of clinical stage I-III or IV did not affect the results, of the analysis. If the patients survived 5 or more years, the HLA-A31 antigen specificity was significantly more common at the beginning of the disease (Chi-square = 15,837; p < 0.005). A negative association for HLA-A11 in the patients with 3 years' survival was observed (Chi-square = 13,355; p < 0.025).
Konieczna
A
A
Department of Otolaryngology, Zeromski' City Hospital, Cracow, Poland.
Turowski
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G
D005260:Female; D005931:Glottis / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D016130:Immunophenotyping; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000401:mortality; D008297:Male; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors; D015996:Survival Rate
D015395:Histocompatibility Antigens Class I