Evaluation of memory in an elevated T maze: a comparison between spontaneously hypertensive, Wistar-Kyoto and Wistar EPM-1 rats.
Four-month old male spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar EPM-1 (EPM-1) rats (14-15 animals per group) were tested in an elevated T maze to evaluate memory. Blood pressures of SHR were hyper at the time of experiment (200-235 mmHg). The elevated T maze used consisted of an open arm at right angles with two enclosed arms elevated 50 cm above the ground. Memory was quantified by the escape latency ratio (the ratio of the time it took for the rat to move from the open arm to one of the enclosed arms in the second session to that in the first session) and by the inhibitory avoidance latency (time from being placed at the end of an enclosed arm to move to the open arm, in a 3rd session). No significant differences in escape latency ratios were observed among SHR, WKY and EPM-1 rats. Conversely, SHR presented a significant reduction in inhibitory avoidance latency as compared to those of WKY and EPM-1 rats (mean +/- SEM latency: 65.9 +/- 18.4 s for SHR, 129.9 +/- 21.8 s for WKY animals and 181.2 +/- 11.2 s for EPM-1 rats). These data were discussed in light of the known lowered reaction to aversive environments exhibited by SHR, as compared to WKY and EPM-1 rats.
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Departamento de Farmacologia, Escola Paulista de Medicina, São Paulo, Brasil.
Goto
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Frussa-Filho
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D000818:Animals; D001007:Anxiety / Q000523:psychology; D001362:Avoidance Learning; D004924:Escape Reaction; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D011930:Reaction Time; D011931:Reactive Inhibition