title: Hepatitis A and evidence against the community dissemination of Helicobacter pylori via feces.
abstract: Seroprevalence data from 1501 subjects was used to test the hypothesis that Helicobacter pylori may be transmitted by the fecal-oral route. Antibody to hepatitis A virus was used as a marker of fecal-oral exposure. Of the 1501 subjects, 35.5% were seropositive for both H. pylori and hepatitis A, 19.1% were seronegative for both, 36.5% were seropositive for hepatitis A only, and 8.8% were seropositive for H. pylori only. Cross-sectional data from rural areas supported an association between hepatitis A and H. pylori. However, in the urban area there was no evidence of hepatitis A infection in persons < 10 years old, yet the seroprevalence of H. pylori was high in this group (approximately 32%). From our data, we suggest that communitywide fecal-oral spread of H. pylori may be of limited importance.
authors.affiliation: School of Microbiology and Immunology, University of New South Wales, Sydney, Australia.
authors.forename: S L
authors.initials: SL
authors.lastname: Hazell
authors.forename: H M
authors.initials: HM
authors.lastname: Mitchell
authors.forename: M
authors.initials: M
authors.lastname: Hedges
authors.forename: X
authors.initials: X
authors.lastname: Shi
authors.forename: P J
authors.initials: PJ
authors.lastname: Hu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Reiss-Levy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005243:Feces / Q000382:microbiology; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000635:transmission*; D016480:Helicobacter pylori; D006506:Hepatitis A / Q000453:epidemiology* / Q000635:transmission*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008875:Middle Aged; D009055:Mouth; D016017:Odds Ratio; D015995:Prevalence; D012424:Rural Population; D014505:Urban Population
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G