title: Enalapril for prevention of restenosis after coronary angioplasty.
abstract: We have evaluated the effect of enalapril in the prevention of restenosis after percutaneous transluminal coronary angioplasty by a randomized trial conducted on 95 patients. The treatment group (n = 46) received enalapril 10 mg/day besides aspirin with calcium blockers, beginning 24 hours before coronary angioplasty. The conventional medical treatment group (n = 49) received only aspirin and calcium blockers. Enrollment required the presence of angina pectoris and successful dilatation of all significant coronary narrowings. All patients were followed up for at least 6 months. Restenosis was identified by symptoms and exercise testing and confirmed by angiography. The incidence of angiographic restenosis was 34% in the enalapril group and 31% in the conventional treatment group. Long term angiotensin converting enzyme inhibition with enalapril in a dose of 10 mg per day does not prevent restenosis after coronary angioplasty.
authors.affiliation: Cardiothoracic Center, All India Institute of Medical Sciences, New Delhi.
authors.forename: U
authors.initials: U
authors.lastname: Kaul
authors.forename: S
authors.initials: S
authors.lastname: Chandra
authors.forename: V K
authors.initials: VK
authors.lastname: Bahl
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: H S
authors.initials: HS
authors.lastname: Wasir
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D003251:Constriction, Pathologic; D017023:Coronary Angiography; D003327:Coronary Disease / Q000517:prevention & control* / Q000628:therapy; D004656:Enalapril / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D004656:Enalapril