Soluble ICAM-1 levels in serum during acute infectious mononucleosis.
Intercellular adhesion molecule-1 (ICAM-1) has been reported as a T-cell, B-cell or macrophage/monocyte activation antigen. We investigated whether soluble ICAM-1 levels in serum increased during the acute stage in 11 patients with infectious mononucleosis (IM). Serum ICAM-1 levels were measured by a double determinant immunoassay using 2 monoclonal antibodies in the FAST system. Serum ICAM-1 levels in patients with IM increased during the acute stage. There was a positive correlation between serum ICAM-1 levels and absolute counts of peripheral blood mononuclear cells. Our results suggest that the elevated serum ICAM-1 levels are based on the increased counts of activated peripheral blood mononuclear cells and that ICAM-1 is a part of the regulatory system of immune reactions during acute IM.
Furukawa
S
S
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Motohashi
T
T
Matsubara
T
T
Imai
K
K
Okumura
K
K
Yabuta
K
K
D000208:Acute Disease; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007118:Immunoassay; D007223:Infant; D007244:Infectious Mononucleosis / Q000097:blood* / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1; D007564:Japan; D007958:Leukocyte Count; D008297:Male; D009000:Monocytes / Q000166:cytology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1