title: Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis.
abstract: Continuous oral pamidronate (APD), 1000 mg/day, was administered to 14 patients with rheumatoid arthritis. A control group of 13 patients with similar conditions received placebo under a double blind randomized study design. Periarticular erosion scores were significantly higher in the control group after 12 months treatment. This was attributed to a deterioration in this group rather than to an improvement in the APD treated one. By contrast, intraarticular narrowing score was not influenced by APD. Tolerance to oral APD was acceptable in all patients.
authors.affiliation: Department of Rheumatology, French Hospital, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Maccagno
authors.forename: E
authors.initials: E
authors.lastname: Di Giorgio
authors.forename: E J
authors.initials: EJ
authors.lastname: Roldan
authors.forename: L E
authors.initials: LE
authors.lastname: Caballero
authors.forename: A
authors.initials: A
authors.lastname: Perez Lloret
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002358:Cartilage, Articular / Q000000981:diagnostic imaging; D004164:Diphosphonates / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005528:Foot / Q000000981:diagnostic imaging; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077268:Pamidronate; D011859:Radiography; D012720:Severity of Illness Index
chemical_list: D004164:Diphosphonates; D000077268:Pamidronate