title: [An autopsy case of urinary bladder carcinoma with pulmonary infarction and subacute cor pulmonale caused by tumor embolization].
abstract: Pulmonary tumor embolism is a common finding at autopsy but is difficult to diagnose clinically antemortem. We report an autopsy case of urinary bladder carcinoma associated with tumor emboli of the pulmonary arteries and subsequent pulmonary infarctions. An eighty-six-year-old man with bloody sputum showed multiple infiltrates on chest X-ray and multiple pleural based parenchymal lesions with truncated apex on computed tomography. The patient had a history of radiation therapy against urinary bladder carcinoma two years earlier. Transitional type carcinoma cells were identified from a urine sample obtained on admission. Three weeks later, the patient developed subacute cor pulmonale and died in severe respiratory distress. Postmortem examination revealed primary carcinoma of the urinary bladder. Multiple tumor emboli of pulmonary arteries and subsequent pulmonary infarctions were visible microscopically. There was a large amount of effusion in both the pleural and the abdominal space. The heart contained focal scarring and mild right ventricular hypertrophy and there was congestion of the lungs, liver, kidneys and spleen. Pulmonary tumor embolization may present at any stage of the patient's illness but rarely causes subsequent pulmonary infarctions. Cytologic examination of blood samples obtained from Swan-Ganz catheters may be useful in the diagnosis of tumor embolization.
authors.affiliation: Department of Internal Medicine, Sasebo City General Hospital, Nagasaki, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Suyama
authors.forename: H
authors.initials: H
authors.lastname: Mashimoto
authors.forename: J
authors.initials: J
authors.lastname: Araki
authors.forename: S
authors.initials: S
authors.lastname: Asai
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeno
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009360:Neoplastic Cells, Circulating; D011655:Pulmonary Embolism / Q000209:etiology* / Q000473:pathology; D011660:Pulmonary Heart Disease / Q000209:etiology* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology*