Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins.
We conducted a prospective randomized trial to compare the efficacy of oral gentamicin versus oral IgA-IgG for the prophylaxis of necrotizing enterocolitis (NEC); 200 newborns considered at high risk for NEC were assigned to group A (oral IgA-IgG, n = 100) or group B (oral Gentamicin, n = 100). NEC was diagnosed in 13 cases in group A and in 1 case in group B between the 3rd and 16th days of life. Surgical treatment was necessary in 3 cases (2 in group A). All infants survived. We conclude that oral gentamicin is more effective than oral IgA-IgG in the prevention of NEC in infants at high risk.
Fast
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Department of Obstetrics and Gynecology, University of Graz, Austria.
Rosegger
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D000284:Administration, Oral; D004338:Drug Combinations; D004754:Enterobacter; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007070:Immunoglobulin A / Q000008:administration & dosage / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use*; D007227:Infant Nutritional Physiological Phenomena; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D004338:Drug Combinations; D005839:Gentamicins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins