title: Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.
abstract: Breast cancer in men is about a hundredfold less common than in women and this has hindered research into its genetic basis. We have examined 22 families with at least one case of male breast cancer for linkage to the hereditary breast and ovarian cancer locus, BRCA1, on chromosome 17q. We found strong evidence against linkage to BRCA1 (lod score-16.63) and the best estimate of the proportion of linked families was 0% (95% CI 0-18%). Our results indicate that there is a gene(s) other than BRCA1 which predisposes to early-onset breast cancer in women and which confers a higher risk of male breast cancer. Identification of additional pedigrees that include cases of male breast cancer may therefore facilitate the mapping and isolation of this gene.
authors.affiliation: Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Stratton
authors.forename: D
authors.initials: D
authors.lastname: Ford
authors.forename: S
authors.initials: S
authors.lastname: Neuhasen
authors.forename: S
authors.initials: S
authors.lastname: Seal
authors.forename: R
authors.initials: R
authors.lastname: Wooster
authors.forename: L S
authors.initials: LS
authors.lastname: Friedman
authors.forename: M C
authors.initials: MC
authors.lastname: King
authors.forename: V
authors.initials: V
authors.lastname: Egilsson
authors.forename: P
authors.initials: P
authors.lastname: Devilee
authors.forename: R
authors.initials: R
authors.lastname: McManus
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics; D010375:Pedigree; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D005819:Genetic Markers