title: Paired helical filament-like inclusions and Hirano bodies in the mesencephalic nucleus of the trigeminal nerve in the aged rat.
abstract: The alterations appearing in trigeminal mesencephalic primary sensory neurons during ageing have been analyzed by electron microscopy in the Wistar-Louvain rat. Two phases have been distinguished, similar to those observed in dorsal root ganglion neurons. Up to 24 months, the mesencephalic trigeminal neurons progressively accumulate lipofuscins, while filamentous inclusions start to appear around 24 months of age. Hirano bodies and paired helical filament-like structures have been identified in animals aged 24 months or more. This time-course parallels the one observed previously in dorsal root ganglion neurons, indicating that the blood-brain barrier does not seem to influence the ageing of mesencephalic trigeminal neurons. The relationship between the paired helical filament-like inclusions and Hirano bodies, as well as similar structures already described by other authors, is discussed.
authors.affiliation: Laboratoire de Biologie Cellulaire, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Klosen
authors.forename: P
authors.initials: P
authors.lastname: van den Bosch de Aguilar
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001933:Brain Stem / Q000648:ultrastructure; D005727:Ganglia, Spinal / Q000648:ultrastructure; D002479:Inclusion Bodies / Q000737:chemistry / Q000648:ultrastructure*; D008062:Lipofuscin / Q000032:analysis; D008636:Mesencephalon / Q000648:ultrastructure; D008854:Microscopy, Electron; D009475:Neurons, Afferent / Q000737:chemistry / Q000648:ultrastructure*; D015388:Organelles / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D014278:Trigeminal Nuclei / Q000737:chemistry / Q000648:ultrastructure*
chemical_list: D008062:Lipofuscin