Changes in gastric mucosal histamine and prostaglandin E2-like activities in relation to portal somatostatin following small bowel resection in guinea-pigs.
The effects of 85% intestinal resection on the portal somatostatin (SLI) gastric mucosal histamine (HA) and prostaglandin E2 (PGE2)-like activities were studied in guinea-pigs. A considerable increase in gastric mucosal HA-like activity of guinea-pigs subjected to small bowel resection (189.9 +/- 15.0 ng/g tissue) was measured in comparison to control values (42.9 +/- 6.3 ng/g tissue) (p < 0.001). The mean tissue PGE2-like activity in the sham operated group was 1636.9 +/- 128.8 ng/g tissue, whereas in the test group it was 650.5 +/- 59.3 ng/g tissue. After 85% small bowel resection a significant fall in portal and systemic venous SLI values was observed (T = 0, p < 0.05). Thus, the small bowel seems to be a major source of the increase of gastric mucosal HA-like activity and the decrease in PGE2-like activity.
Engin
A
A
Department of Surgery, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey.
Atlan
N
N
Ercan
Z S
ZS
Ersoy
E
E
Demirag
A
A
D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D005753:Gastric Mucosa / Q000502:physiology*; D006168:Guinea Pigs; D006632:Histamine / Q000096:biosynthesis; D007421:Intestine, Small / Q000502:physiology / Q000601:surgery*; D008297:Male; D011168:Portal System / Q000502:physiology*; D013004:Somatostatin / Q000096:biosynthesis
D013004:Somatostatin; D006632:Histamine; D015232:Dinoprostone