Transient depletion of T cells with bright CD11a/CD18 expression from peripheral circulation during acute Kawasaki disease.
To clarify the activation of peripheral blood T cells in Kawasaki disease (KD) patients, we investigated whether expression of lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18) and/or intercellular adhesion molecule-1 (ICAM-1, CD54) on peripheral blood T cells increases during the acute stage. Expression of cellular adhesion molecules was measured using flow cytometry. There was a decrease in the percentage of CD3+ T cells in the bright LFA-1 alpha and LFA-1 beta population and a concomitant increase in the dim population of LFA-1 alpha and LFA-1 beta during the acute stage, in comparison with those of the convalescent stage. In addition, we observed no significant differences in ICAM-1 expression during the acute stage compared with that of the convalescent stage. In our view the present data, in conjunction with previous reports on T-cell function during acute KD, suggest that activated T cells are temporarily withdrawn from peripheral circulation during acute KD.
Furukawa
S
S
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Matsubara
T
T
Tsuji
K
K
Okumura
K
K
Yabuta
K
K
D000208:Acute Disease; D015703:Antigens, CD / Q000276:immunology; D018821:CD18 Antigens; D017252:CD3 Complex / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007958:Leukocyte Count; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D018821:CD18 Antigens; D017252:CD3 Complex; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1