Centpropazine affinity to cortical noradrenergic receptors and effect on their responsiveness in the rat.
We have studied the in-vitro effect of centpropazine on cerebral cortical noradrenergic receptors measured as the accumulation of second messengers, cyclic AMP and inositol phosphate, stimulated by noradrenaline, and the binding to alpha 1- and beta-adrenoceptors. Centpropazine inhibited inositol phosphate, but not the cyclic AMP accumulation in the cerebral cortical slices of the rat. It moderately antagonized the specific binding of [3H]prazosin, but did not affect the specific binding of the beta-adrenoceptor ligand, [3H]CGP 12177, to cerebral cortical membranes.
Dikshit
M
M
Department of Biochemistry, Polish Academy of Sciences, Krakow.
Chalecka-Franaszek
E
E
Nalepa
I
I
D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism*; D001667:Binding, Competitive / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism; D008297:Male; D008566:Membranes / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010879:Piperazines; D011224:Prazosin / Q000378:metabolism; D011412:Propanolamines / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D007295:Inositol Phosphates; D010879:Piperazines; D011412:Propanolamines; D011941:Receptors, Adrenergic; C044266:centpropazine; C033394:CGP 12177; D009638:Norepinephrine; D011224:Prazosin