Hepatitis E virus transmission to a volunteer.
Hepatitis E virus (HEV) causes an enteric non-A, non-B hepatitis. The disease occurs in epidemic settings and sporadically, and viral transmission is thought to be faecal-oral. We present here a single volunteer study of HEV transmission followed by disease. Clinical and biochemical features of the infection correlated with HEV detection in the stools and sera by reverse transcription/polymerase chain amplification. IgG antibody has persisted for 2 years. The presence of HEV in serum before clinical signs appeared suggests that in endemic areas sporadic transmission of HEV may also occur parenterally.
Chauhan
A
A
Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Jameel
S
S
Dilawari
J B
JB
Chawla
Y K
YK
Kaur
U
U
Ganguly
N K
NK
D005243:Feces / Q000382:microbiology; D016751:Hepatitis E / Q000382:microbiology / Q000635:transmission*; D016752:Hepatitis E virus / Q000302:isolation & purification; D006801:Humans; D008297:Male