Colorectal cancer recurrence and perioperative blood transfusions: a critical reappraisal.
The last 2 decades the immunomodulatory effect of blood transfusions has been investigated intensively. The effect of blood transfusions on the prognosis of colorectal cancer patients is reviewed in this paper. We made an evaluation of the material from animal and from clinical studies present in the literature. The results from clinical randomized trials dealing with this subject, which have been published recently, are discussed as well.
Busch
O R
OR
Department of Surgery, University Hospital Rotterdam-Dijkzigt, The Netherlands.
Marquet
R L
RL
Hop
W C
WC
Jeekel
J
J
D000818:Animals; D001804:Blood Transfusion, Autologous / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007165:Immunosuppression Therapy; D015201:Meta-Analysis as Topic; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D065227:Transfusion Reaction