title: [New directions in the hypotensive therapy of open-angle glaucoma (experimental and clinical research)].
abstract: Clinical use of eye drops of a hybrid beta-alpha-adrenoblocker OF-4680 to reduce intraocular pressure has shown a high efficacy of the drug, not inferior to thymolol, for local hypotensive therapy of open-angle glaucoma. A combination of thymolol with taurin helped reduce the inhibiting effect of the beta-blocker on chamber humor secretion and simultaneously enhanced its discharge. The results evidence the desirability of correcting glutathion deficiency, detected in the patients with narrow-angle glaucoma, by lipoic acid.
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Bunin
authors.forename: V N
authors.initials: VN
authors.lastname: Ermakov
authors.forename: A A
authors.initials: AA
authors.lastname: Filina
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004338:Drug Combinations; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D009930:Organic Chemicals; D011817:Rabbits; D013654:Taurine / Q000627:therapeutic use; D013943:Thymol / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D004338:Drug Combinations; C081878:OF 4647; C081877:OF 4680; D009883:Ophthalmic Solutions; D009930:Organic Chemicals; D013654:Taurine; D013943:Thymol
vernacular_title: Novye napravleniia gipotenzivnoĭ terapii otkrytougol'noĭ glaukomy (éksperimental'no-klinicheskie issledovaniia).