Serum levels of soluble CD8, neopterin, beta 2-microglobulin and p24 antigen as indicators of disease progression in children with AIDS on zidovudine therapy.
OBJECTIVE
To test the hypothesis that serum levels of soluble markers in children change after initiation of zidovudine therapy and that the extent and pattern of these longitudinal changes correlates with clinical outcome.


METHODS
We measured serum levels of soluble CD8, neopterin, beta 2-microglobulin (beta 2M), and p24 antigen, and CD4 cell counts, before the initiation of zidovudine therapy and at 12, 24 and 48 weeks of treatment in 24 HIV-1-infected children (Centers for Disease Control classification P2) and 15 controls.


RESULTS
Soluble CD8 levels were elevated before therapy in 70% of the infected children; subsequent decreases were associated with lower risk of disease progression. The mean serum neopterin level before treatment was elevated in infected children; decreases in neopterin levels marginally reflected improved or stable clinical status. Serum beta 2M levels and CD4+ cell counts were not associated with clinical outcome. Only 10 out of the 24 patients had detectable levels of serum p24 antigen before treatment; again, the amount of decline after initiation of therapy did not predict clinical outcome.


CONCLUSIONS
Decreasing levels of soluble CD8 and neopterin in HIV-1-infected children receiving zidovudine therapy might reflect a good response to treatment and a slowing of disease progression.
Siller
L
L
Department of Pediatrics, University of California, San Francisco.
Martin
N L
NL
Kostuchenko
P
P
Beckett
L
L
Rautonen
J
J
Cheng
S C
SC
Wara
D W
DW
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D001708:Biopterins / Q000031:analogs & derivatives* / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes; D016827:CD8 Antigens / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016655:HIV Core Protein p24 / Q000097:blood*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D019798:Neopterin; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015215:Zidovudine / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000032:analysis*
D015415:Biomarkers; D016827:CD8 Antigens; D016655:HIV Core Protein p24; D001613:beta 2-Microglobulin; D001708:Biopterins; D015215:Zidovudine; D019798:Neopterin