Mobilization and distribution of beryllium over the course of chelation therapy with some polyaminocarboxylic acids in the rat.
The efficacy of three common polyaminocarboxylic acids in the treatment of experimental beryllium intoxication was investigated in male rats. N-(2-hydroxyethyl) ethylene diamine triacetic acid (HEDTA) was more effective than calcium disodium ethylenediamine tetraacetic acid (CaNa2EDTA) in reducing the beryllium concentration of the blood, kidneys and spleen and reducing beryllium-induced inhibition of hepatic alkaline phosphatase activity. HEDTA was also most effective in reducing histopathological lesions in the liver and spleen. Compared to these two chelators, the third amino chelator, calcium trisodium diethylene triaminepenta acetic acid (CaNa3DTPA) produced severe deleterious effects in the liver and systemic toxicity. The results suggest that HEDTA is a promising chelator for beryllium toxicity while DTPA enhances the toxic manifestation of beryllium.
Mathur
S
S
School of Studies in Zoology, Jiwaji University, Gwalior, India.
Flora
S J
SJ
Mathur
R
R
Das Gupta
S
S
D000818:Animals; D001607:Berylliosis; D001608:Beryllium / Q000378:metabolism; D002614:Chelating Agents / Q000627:therapeutic use*; D015913:Chelation Therapy; D056486:Chemical and Drug Induced Liver Injury; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D004369:Pentetic Acid / Q000627:therapeutic use; D051381:Rats; D013158:Splenic Diseases / Q000139:chemically induced / Q000188:drug therapy
D002614:Chelating Agents; D004369:Pentetic Acid; D004492:Edetic Acid; D001608:Beryllium; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid