Simultaneous presentation of sarcoidosis and acute myeloid leukaemia: predisposition to pulmonary haemorrhage.
A case of coexistent acute myeloid leukaemia and sarcoidosis is reported. This was complicated by recurrent pulmonary haemorrhage during reinduction and consolidation chemotherapy. A review of published papers on malignancy and sarcoidosis, in particular acute leukaemia is given. The outcome of most cases of acute leukaemia and sarcoidosis is poor with respiratory complications a frequent cause of death in this group. It is proposed that modifications to treatment to avoid pulmonary toxicity and maintenance of platelet counts above 40 x 10(9)/l are warranted to reduce the risk of this complication.
Williams
B
B
Department of Haematology, Royal Brisbane Hospital, Herston, Queensland, Australia.
Francis
A
A
Durrant
S
S
D000328:Adult; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008171:Lung Diseases / Q000150:complications / Q000209:etiology; D008297:Male; D012507:Sarcoidosis / Q000150:complications*