Delusional depression in Parkinson's disease.
A 72 year-old female patient is presented in whom delusional depression, a possible distinct subtype of depressive illness characterized by a selective decrease of cerebrospinal fluid (CSF) norepinephrine (NE) metabolism, preceded the onset of Parkinsonism by several years. The report suggests that delusional depression may be a particular manifestation of depressive illness in Parkinsonian patients. In addition, since the activity of plasma and cerebrospinal fluid (CSF) dopamine beta-hydroxylase (DBH) is genetically determined, the co-occurrence of delusional depression and Parkinsonism in this patient may be related to a common underlying genetic defect that expresses itself biochemically by reduced cerebral NE metabolism.
Sandyk
R
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NeuroCommunication Research Laboratories, Danbury, CT 06811.
D000368:Aged; D003702:Delusions / Q000150:complications* / Q000378:metabolism; D003866:Depressive Disorder / Q000150:complications* / Q000378:metabolism; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications* / Q000235:genetics / Q000628:therapy
D009638:Norepinephrine