[Zonisamide monotherapy against absence attacks: report of two cases].
We report two cases of absence seizures, in which zonisamide monotherapy was effective. In one case the attacks recurred 6 months after the beginning of zonisamide therapy but ceased again with an increase of the dosage. The EEG prior to treatment showed 3 Hz generalized spike-wave patterns and 3 Hz high voltage slow wave burst in the right occipital area in one case, and 3.5-4 Hz generalized spike-wave patterns and focal spike-wave complexes in the left frontal to central areas in the other. One of the generalized spike-wave patterns were preceded by right occipital delta wave burst in one case, and bilateral occipital sharp-wave complex in the other. It is suggested that zonisamide monotherapy may be effective against absence seizures with focal paroxysmal discharges.
Kotani
H
H
Department of Pediatrics, Kyoto Prefectural University of Medicine.
Hirai
K
K
Nishiki
T
T
Yamazoe
I
I
Okano
S
S
Takeuchi
Y
Y
Yoshioka
H
H
Sawada
T
T
D002648:Child; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage*; D000078305:Zonisamide
D007555:Isoxazoles; D000078305:Zonisamide