Lymphatic absorption of enterally fed structured triacylglycerol vs physical mix in a canine model.
The lymphatic absorption of a structured triacylglycerol vs an equivalent physical mixture of the constituent medium-chain triacylglycerol and fish oils was studied. Each of four canines served as its own control in a crossover feeding design with the investigators unaware of diet contents. Lymphatic absorption of n-3 and medium-chain fatty acids peaked within 4-8 h of feeding either diet. The lymph contained more 10:0 fatty acids than 8:0 despite an overall ratio of 10:0 to 8:0 of 0.3 for the diets. The mass of medium-chain fatty acids absorbed in the lymph at measured time points was 2.6 +/- 0.5-fold higher (mean +/- SE of 12 determinations) for the structured triacylglycerol compared with the physical mix. Molecular species analyses revealed that the medium-chain fatty acids in lymph were present as mixed triacylglycerols. The unique molecular structure of these mixed triacylglycerols and the fatty acids at the 2-position may account for the improved absorption.
Jensen
G L
GL
Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, PA 17822.
McGarvey
N
N
Taraszewski
R
R
Wixson
S K
SK
Seidner
D L
DL
Pai
T
T
Yeh
Y Y
YY
Lee
T W
TW
DeMichele
S J
SJ
D000042:Absorption; D000818:Animals; D004285:Dogs; D004750:Enteral Nutrition; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008208:Lymphatic System / Q000378:metabolism*; D014280:Triglycerides / Q000008:administration & dosage* / Q000032:analysis / Q000378:metabolism*
D005227:Fatty Acids; D014280:Triglycerides