title: Effects of different weight loss treatments on weight cycling and metabolic measures in male mice.
abstract: The effects of different weight loss treatments on subsequent weight regain, food efficiency, body composition, metabolic rate, and corticosterone concentrations were investigated in obese male B6D2F1 mice. Treatment groups were: restricted (RES, food restricted); exercised (EX, treadmill exercised); sham control (SHAM, treadmill exposure, not exercised); lab chow control (LC). Weight loss, regardless of treatment, resulted in increased rate of weight regain and food efficiency. There were significant alterations in body composition after a cycle of weight gain/loss. These results demonstrate that a cycle of weight gain/loss causes increased food efficiency and concomitant alterations in body composition in male mice.
authors.affiliation: Department of Health Studies and Gerontology, University of Waterloo, Ontario, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Simpson
authors.forename: P E
authors.initials: PE
authors.lastname: Wainwright
authors.forename: L
authors.initials: L
authors.lastname: Hoffman-Goetz
authors.forename: S
authors.initials: S
authors.lastname: Lévesque
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008820:Mice, Obese; D005082:Physical Exertion / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D003345:Corticosterone