title: [Rheumatoid arthritis terminating in multiple myeloma].
abstract: A 65-year-old woman with a 25-year history of rheumatoid arthritis (RA) was admitted because of acute pneumonia in January, 1991. Then she was pointed out M proteinemia (IgG 3,220 mg/dl, IgA 139 mg/dl, IgM 216 mg/dl) for the first time. Serum IL-6 was below 4.0 pg/ml. She was followed up because of lack of bone change. Plasma cell count in bone marrow were 14.6%. She was re-admitted because of development of bone lesions March, 1992. There was no joint pains, and serum IgG, IgA and IgM were 5,148 mg/dl, 114 mg/dl and 106 mg/dl, respectively. CRP was negative. Serological tests of rheumatoid factor and antinuclear antibody were both positive. Serum IL-6 was elevated to 14.8 pg/ml. Bone marrow aspiration disclosed 30.6% myeloma cells. Serum IgG, A, and M were 5,148 mg/dl, 114 mg/dl and 106 mg/dl, respectively. Serum immunoelectrophoresis showed monoclonal IgG with kappa type light chain. X-ray findings revealed radiolucent myelomatous foci. From these findings, IgG kappa-type multiple myeloma with RA was diagnosed.
authors.affiliation: Department of Internal Medicine, Miki City Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmae
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D015850:Interleukin-6 / Q000097:blood; D009101:Multiple Myeloma / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D015850:Interleukin-6