Adaptation of the small intestine in desert-dwelling animals: morphology, ultrastructure and electrolyte transport in the jejunum of rabbits, rats, gerbils and sand rats.
1. The aim of this study was to characterize adaptive alterations of the small intestine in desert-dwelling animals by comparing jejunal morphology, ultrastructure and function in mammalian species with or without desert habitat origins. 2. Crypt-villus architecture, brush border surface area, and electrolyte transport were measured and compared in the jejunum of rabbits (Oryctolagus cuniculus), rats (Rattus rattus), gerbils (Meriones unguiculatus) and sand rats (Psammomys obesus). 3. In addition, transport of 3-0-methyl-D-glucose was compared in rats, rabbits and gerbils. 4. Gerbils and sand rats had significantly longer microvilli and villi (P < 0.01), increased brush border surface area (P < 0.01), and greater absorption of Na+ and Cl- (P < 0.05) than rabbits and rats. 5. Absorption of 3-0-methyl-D-glucose was also significantly (P < 0.05) greater in gerbils than in rabbits or rats. 6. The findings demonstrate enhanced small intestinal absorption of electrolytes and nutrients in desert-dwelling animals. 7. This increase was associated with an enlarged mucosal absorptive surface area. 8. The findings suggest that intestinal mucosal adaptation allows desert-dwelling animals to compensate for the limited availability of water and nutrients in an arid environment.
Buret
A
A
Department of Pediatrics, University of Calgary, AB, Canada.
Hardin
J
J
Olson
M E
ME
Gall
D G
DG
D019325:3-O-Methylglucose; D000222:Adaptation, Physiological; D000818:Animals; D001692:Biological Transport; D003889:Desert Climate; D004573:Electrolytes / Q000378:metabolism*; D005849:Gerbillinae; D007583:Jejunum / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D008757:Methylglucosides / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D004573:Electrolytes; D008757:Methylglucosides; D019325:3-O-Methylglucose