title: The vulnerability/stress model of schizophrenic relapse: a longitudinal study.
abstract: A tentative model for conceptualizing the interplay of vulnerability factors, stressors, and protective factors in the course of schizophrenia is discussed. A study of the initial years after a first schizophrenic episode is testing the predictive role of key factors. During an initial 1-year period of depot antipsychotic medication, independent life events and expressed emotion were found to predict the likelihood of psychotic relapse. Initial analyses indicate that independent life events play less of a role in relapse prediction during a medication-free period. These results suggest that maintenance antipsychotic medication raises the threshold for return of psychotic symptoms, such that relapses are less likely unless major environmental stressors occur. A low expressed emotion environment may be a protective factor.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles 90024-6968.
authors.forename: K H
authors.initials: KH
authors.lastname: Nuechterlein
authors.forename: M E
authors.initials: ME
authors.lastname: Dawson
authors.forename: J
authors.initials: J
authors.lastname: Ventura
authors.forename: M
authors.initials: M
authors.lastname: Gitlin
authors.forename: K L
authors.initials: KL
authors.lastname: Subotnik
authors.forename: K S
authors.initials: KS
authors.lastname: Snyder
authors.forename: J
authors.initials: J
authors.lastname: Mintz
authors.forename: G
authors.initials: G
authors.lastname: Bartzokis
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004644:Emotions; D005260:Female; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008297:Male; D008960:Models, Psychological; D015999:Multivariate Analysis; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012559:Schizophrenia / Q000209:etiology* / Q000517:prevention & control; D012931:Social Environment; D013315:Stress, Psychological / Q000523:psychology*