title: [Zonisamide monotherapy against absence attacks: report of two cases].
abstract: We report two cases of absence seizures, in which zonisamide monotherapy was effective. In one case the attacks recurred 6 months after the beginning of zonisamide therapy but ceased again with an increase of the dosage. The EEG prior to treatment showed 3 Hz generalized spike-wave patterns and 3 Hz high voltage slow wave burst in the right occipital area in one case, and 3.5-4 Hz generalized spike-wave patterns and focal spike-wave complexes in the left frontal to central areas in the other. One of the generalized spike-wave patterns were preceded by right occipital delta wave burst in one case, and bilateral occipital sharp-wave complex in the other. It is suggested that zonisamide monotherapy may be effective against absence seizures with focal paroxysmal discharges.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Kotani
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Nishiki
authors.forename: I
authors.initials: I
authors.lastname: Yamazoe
authors.forename: S
authors.initials: S
authors.lastname: Okano
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Yoshioka
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D002648:Child; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage*; D000078305:Zonisamide
chemical_list: D007555:Isoxazoles; D000078305:Zonisamide