Technetium-99m labeled somatostatin and analogs: synthesis, characterization and in vivo evaluation.
Technetium-99m complexes of somatostatin and analogs were synthesized following the introduction of sulfhydryl groups with 2-iminothiolane (Traut's Reagent). In rats the complex was taken up by the liver, kidneys, adrenals, lungs and the pancreas. Analysis of urine samples of treated rats showed that the radiochemicals have reasonably good in vivo stability. This implies that the complexes may be potentially useful for biochemical characterization of somatostatin receptors and also in scintigraphic detection of somatostatin receptor positive tumors, especially for metastatic deposits in patients on somatostatin therapy.
Amartey
J K
JK
Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004355:Drug Stability; D007096:Imidoesters / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods; D007700:Kinetics; D008297:Male; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002614:Chelating Agents; D003432:Cross-Linking Reagents; D007096:Imidoesters; D015609:Organotechnetium Compounds; D013004:Somatostatin; C005905:methyl 4-mercaptobutyrimidate