Guillain-Barré syndrome in pregnancy: reflections on immunopathogenesis.
Here we describe the case of a 29-year-old woman, 36 weeks pregnant, with severe Guillain-Barré syndrome who delivered by Caesarean section because of respiratory insufficiency. The detection of high antibody titers to glycolipids of human peripheral nerve myelin in both the mother and the newborn, as well as differences regarding lymphocyte typing and levels of complement components, give rise to some reflections on the immunopathogenesis of this disorder supporting the hypothesis that cell-mediated immunity is the major mechanism in the development of Guillain-Barré syndrome.
Rolfs
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Neurochemical Research Laboratory, Klinikum Steglitz, Free University of Berlin, Germany.
Bolik
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D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D011129:Polyradiculoneuropathy; D011247:Pregnancy
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D016827:CD8 Antigens; D002556:Cerebrospinal Fluid Proteins; D006684:HLA-DR Antigens; D007074:Immunoglobulin G