Effects of pectenotoxin-1 on liver cells in vitro.
The effects of pectenotoxin-1 (PTX1), a nondiarrheagenic toxin from mussels, on liver cells were investigated by fluorescence microscopy. The in vitro application of PTX1 to these cells induced reduction in number and loss in radial arrangement of microtubules. It also induced disruption of stress fibers and accumulation of actin at the cellular peripheries. Further studies are worthwhile to explore the feasibility of using PTX1 as a tool for analyzing the properties of cytoskeletal proteins.
Zhou
Z H
ZH
Department of Anatomy and Cell Biology, School of Medicine, Chiba University, Japan.
Komiyama
M
M
Terao
K
K
Shimada
Y
Y
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D018942:Macrolides; D008387:Marine Toxins / Q000633:toxicity*; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure; D011714:Pyrans / Q000633:toxicity*; D000095702:Polyether Toxins
D018942:Macrolides; D008387:Marine Toxins; D011714:Pyrans; C051905:pectenotoxin 1; D000095702:Polyether Toxins