[Characteristics of carbohydrate metabolism regulation during correction of congenital heart defects and hypothermic protection without perfusion].
Carbohydrate metabolism and insulin status have been studied in 89 patients with congenital heart valve defects operated on in conditions of profound perfusion-free hypothermic protection. It has been established that anesthesia, hypothermia, and surgical trauma are accompanied by hyperinsulinemia, which had nothing to do with the introduction of exogenic hormone. Insulin effect is attenuated and insulin resistance develops, which leads to a drop not only in glucose consumption but also in the consumption of glycolysis products. Single insulin injection during induction to anesthesia at a dose of 0.5 U/kg was insufficient for normalization of carbohydrate homeostasis. Glycolysis activation with a considerable increase in blood pyruvate level has been observed, which decreases lactate/pyruvate coefficient informative value at different stages of surgical treatment of heart valve defects.
Tsvetovskaia
G A
GA
Litasova
E E
EE
Kniaz'kova
L G
LG
Shun'kin
A V
AV
Evnina
I I
II
D000293:Adolescent; D050260:Carbohydrate Metabolism; D002648:Child; D002675:Child, Preschool; D006019:Glycolysis; D006330:Heart Defects, Congenital / Q000601:surgery*; D006349:Heart Valve Diseases / Q000151:congenital / Q000601:surgery; D006706:Homeostasis; D006801:Humans; D007036:Hypothermia, Induced; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood; D011773:Pyruvates / Q000097:blood
D007328:Insulin; D007773:Lactates; D011773:Pyruvates
Osobennosti reguliatsii metabolizma uglevodov pri korrektsii vrozhdennykh porokov serdtsa v usloviiakh besperfuzionnoĭ gipotermicheskoĭ zashchity.