title: Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig.
abstract: The subacute toxic effects of dietary deoxynivalenol (DON) were examined in grower pigs during a 32 day feeding period. DON was incorporated into the feed at 0, 1, and 3 mg/kg, added as either the purified toxin (P) or as naturally contaminated corn (N). Growth performance and blood biochemical and haematological parameters were monitored throughout the study. At the higher toxin levels (diets 3P, 3N) significantly lower feed consumption and body weight gains were evident soon after the start of feeding, but while weight gains of pigs fed the pure DON diet (3P) recovered after several days, values for pigs fed the naturally contaminated diet (3N) remained depressed over the course of the study. It is possible that these observations reflected the presence of other unidentified toxic compounds in the naturally contaminated grain. Generally, blood chemistry parameters of pigs fed the contaminated diets were not different from controls, with the exception of alpha-globulin and possibly cortisol in animals receiving diets 3N or 3P. Data suggested that the effect of DON on the alpha-globulin fraction may have been independent of the feed refusal syndrome associated with this toxin. Alterations in several haematological measurements were noted to occur sporadically with the 3 ppm diets, including higher RBC count, haematocrit and platelet level, however these effects could not be separated from the influence of decreased feed intake and were of limited value in diagnosing the effects of low level dietary DON on swine.
authors.affiliation: Centre for Food and Animal Research, Agriculture and Agrifood Canada, Ottawa.
authors.forename: D B
authors.initials: DB
authors.lastname: Prelusky
authors.forename: R G
authors.initials: RG
authors.lastname: Gerdes
authors.forename: K L
authors.initials: KL
authors.lastname: Underhill
authors.forename: B A
authors.initials: BA
authors.lastname: Rotter
authors.forename: P Y
authors.initials: PY
authors.lastname: Jui
authors.forename: H L
authors.initials: HL
authors.lastname: Trenholm
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001774:Blood Chemical Analysis / Q000662:veterinary; D001798:Blood Proteins / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011897:Random Allocation; D013552:Swine / Q000097:blood / Q000502:physiology*; D014255:Trichothecenes / Q000008:administration & dosage / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D014255:Trichothecenes; C007262:deoxynivalenol; D006854:Hydrocortisone