title: D-dimer plasma measurement in patients undergoing major hip surgery: use in the prediction and diagnosis of postoperative proximal vein thrombosis.
abstract: Plasma D-Dimer (DD), a highly sensitive marker of venous thromboembolism, was measured with an ELISA assay preoperatively and on the 12th postoperative day in 173 patients undergoing major hip surgery (78 elective arthroplasties and 95 operations for fractures). Proximal deep venous thrombosis (DVT) was detected by systematic compression venous ultrasonography on the 12th postoperative day in 12 (7%) patients. In one additional case, proximal DVT was diagnosed by venography. Preoperative DD level was significantly higher in patients with fracture than in patients undergoing elective arthroplasty. At a cutoff of 500 micrograms/L as determined by ROC curve analysis, the sensitivity, specificity, positive and negative predictive values of the pre-operative DD concentration for the development of subsequent proximal DVT were 93%, 23%, 36% and 96%, respectively. The diagnostic exclusion value of the DD measurement on the 12th postoperative day was similar but for a cutoff of 2000 micrograms/L. These data suggest that plasma DD measurement might be useful to predict and diagnose proximal DVT following major hip surgery.
authors.affiliation: Division of Angiology and Hemostasis, University Hospital of Geneva, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Bongard
authors.forename: J
authors.initials: J
authors.lastname: Wicky
authors.forename: R
authors.initials: R
authors.lastname: Peter
authors.forename: S
authors.initials: S
authors.lastname: Simonovska
authors.forename: J J
authors.initials: JJ
authors.lastname: Vogel
authors.forename: P
authors.initials: P
authors.lastname: de Moerloose
authors.forename: G
authors.initials: G
authors.lastname: Reber
authors.forename: H
authors.initials: H
authors.lastname: Bonameaux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006620:Hip Fractures / Q000097:blood / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011300:Preoperative Care; D013924:Thrombophlebitis / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D