title: Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease.
abstract: A survey of 8080 subjects was conducted in Baltimore, examining the association between infection with hantaviruses and renal disease. Two groups (N = 6060) with no known risk factors were selected to establish a baseline antibody prevalence. Overall, antibody prevalence was 0.25%. Seroprevalence increased with age, without sex- or race-related differences. Patients with proteinuria showed the same patterns of infection but were more commonly seropositive (1.46%) than the reference group (OR, 3.23; P < .05). Infection among dialysis patients with end-stage renal disease was 2.76%, significantly higher than in the reference group (OR, 5.03; P < .05). In the proteinuria and the dialysis groups, hantavirus infection was consistently associated with a diagnosis of hypertensive renal disease. The association was unrelated to other chronic renal disease diagnoses. Overall, 6.5% of patients with end-stage renal disease due to hypertension were seropositive for a hantavirus. These data suggest that hantavirus infection is associated with hypertensive renal disease.
authors.affiliation: Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
authors.forename: G E
authors.initials: GE
authors.lastname: Glass
authors.forename: A J
authors.initials: AJ
authors.lastname: Watson
authors.forename: J W
authors.initials: JW
authors.lastname: LeDuc
authors.forename: G D
authors.initials: GD
authors.lastname: Kelen
authors.forename: T C
authors.initials: TC
authors.lastname: Quinn
authors.forename: J E
authors.initials: JE
authors.lastname: Childs
mesh_terms: D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D015142:Baltimore / Q000453:epidemiology; D002908:Chronic Disease; D005260:Female; D006476:Orthohantavirus / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D011507:Proteinuria / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006435:Renal Dialysis
chemical_list: D000914:Antibodies, Viral