Release of indomethacin from transparent oil-water gels.
Within the scope of evaluating transparent oil-water gels (TOW gel) as dermatological vehicles, the release of indomethacin from a model TOW gel into 1-dodecanol is studied at various pH levels of the water phase. Apparent partition coefficient determinations and flame photometrical measurements show that both indomethacin and its sodium salt, as the ion pair, migrate into the 1-dodecanol layer. The pH-dependent release-rate profile is explained in terms of the amount of readily diffusible drug in the water phase of the gel.
De Vos
A
A
Laboratory of Galenical and Clinical Pharmacy, Catholic University of Leuven, Belgium.
Vervoort
L
L
Kinget
R
R
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D007851:Dodecanol / Q000737:chemistry*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry*; D007700:Kinetics; D014867:Water / Q000737:chemistry*
D005782:Gels; D014867:Water; D007851:Dodecanol; D007213:Indomethacin