Effect of amitriptyline on neurotransmitter levels in adult mice following infection with the avirulent strain of Semliki Forest virus.
Infection of adult mice with the avirulent strain of Semliki Forest virus (SFV) led to neurochemical abnormalities, notably depressed levels of catecholamines (CATs) such as noradrenaline (NA), adrenaline (A) and 3-methoxy-4-hydroxyphenylglycol (MHPG) (a metabolite of NA) particularly in the hypothalamus and the inferior colliculus but not in the temporal cortex. In addition, depressed levels of NA and A were also found in the cerebrospinal fluid (CSF) and the serum. Administration of a tricyclic antidepressant drug, amitriptyline, kept the levels of NA, A and MHPG similar to those of the saline-treated control mice in the hypothalamus, inferior colliculus and CSF.
Mehta
S
S
Neurovirology Unit, Rayne Institute, United Medical and Dental School, Guy's Hospital, London, UK.
Parsons
L M
LM
Webb
H E
HE
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004837:Epinephrine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007245:Inferior Colliculi / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D012672:Semliki forest virus; D013702:Temporal Lobe / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014036:Togaviridae Infections / Q000378:metabolism*
D018377:Neurotransmitter Agents; D000639:Amitriptyline; D008734:Methoxyhydroxyphenylglycol; D009638:Norepinephrine; D004837:Epinephrine