A double-blind study of neurotropin in patients with acute ischemic stroke.
Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea-pig. A randomized double-blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo-randomized patients had to be excluded. 10 included patients in the neurotropin and 13 in the placebo-treated group died within the study period of 15 days. A better clinical outcome was observed in the 65 included surviving neurotropin compared with the 56 placebo-treated patients. The size of the infarct and of the oedema zones was significantly more decreased on CT scans from Day 11 compared with Day 3 after stroke in the neurotropin than in the placebo treated group. Neurotropin is helpful in treating brain oedema, related to acute ischemic stroke.
De Reuck
J
J
Department of Neurology, University Hospital, Ghent, Belgium.
Decoo
D
D
Vanderdonckt
P
P
Dallenga
A
A
Ceusters
W
W
Kalala
J P
JP
De Meulemeester
K
K
Abdullah
J
J
Santens
P
P
Huybrechts
J
J
D000368:Aged; D001921:Brain / Q000503:physiopathology; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010919:Placebos; D011134:Polysaccharides / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D010919:Placebos; D011134:Polysaccharides; C010491:neurotropin