title: The dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane.
abstract: This report documents the radiation dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane [123I]beta-CIT in humans. The mean absorbed doses for various organs and the effective dose equivalent were estimated from whole-body scans, blood samples and single-photon emission tomography scans acquired up to 22 h after the injection of a known amount of tracer. The basal ganglia, the liver and the lower large intestinal wall received the highest mean absorbed doses of 0.270 mGy/MBq, 0.038 mGy/MBq and 0.034 mGy/MBq, respectively. The effective dose equivalent for adults was estimated using 11 organs and the ICRP-87 radiation dose model and was 0.031 mSv/MBq. The radiation dose to the basal ganglia limits the maximum injected activity of [125I]beta-CIT to 185 MBq for a single study.
authors.affiliation: Department of Clinical Physiology, Kuopio University Hospital, Finland.
authors.forename: J T
authors.initials: JT
authors.lastname: Kuikka
authors.forename: K A
authors.initials: KA
authors.lastname: Bergström
authors.forename: A
authors.initials: A
authors.lastname: Ahonen
authors.forename: E
authors.initials: E
authors.lastname: Länsimies
mesh_terms: D000328:Adult; D003042:Cocaine / Q000031:analogs & derivatives*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011874:Radiometry; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine