Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides.
CD and uv-visible absorption studies with several tetracationic water-soluble porphyrin derivatives show that some of these species can serve as probes to discriminate between A- and B-conformational forms of single-stranded polynucleotides. It is also observed that these porphyrins can participate in the formation of double helices by forming transient intermediate complexes en-route to duplex formation.
Bustamante
C
C
Department of Chemistry, University of Oregon, Eugene 97403.
Gurrieri
S
S
Pasternack
R F
RF
Purrello
R
R
Rizzarelli
E
E
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000737:chemistry; D009690:Nucleic Acid Conformation; D011131:Polyribonucleotides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D012330:RNA, Double-Stranded / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry*
D011131:Polyribonucleotides; D011166:Porphyrins; D012330:RNA, Double-Stranded; D014867:Water; D004247:DNA