Structure, regulation and role of 3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues.
In addition to the classical steroidogenic tissues, namely the ovaries, testes, adrenals and placenta, a large series of human peripheral tissues possess all the enzymatic systems required for the formation of active androgens and oestrogens from a relatively large supply of precursor steroids provided by the adrenals. This chapter describes the structure, function, tissue-specific expression and regulation of the 3 beta-HSD and 17 beta-HSD gene families as well as some information about the aromatase gene. While, so far, most therapeutic approaches have been aimed and limited at controlling steroid formation by the classical steroidogenic tissues, it is clear that major efforts should now be turned towards intracrinology in order to understand better the physiological mechanisms controlling local steroid formation in peripheral target tissues and thus be in a position to develop novel therapeutic approaches that take into account the high proportion of steroids that are made locally and are responsible for the growth and function of normal as well as cancerous tissue.
Labrie
F
F
Centre Hospitalier de l'Université Laval/CHUL Research Center, Laboratory of Molecular Endocrinology, Quebec, Canada.
Simard
J
J
Luu-The
V
V
Pelletier
G
G
Belghmi
K
K
Bélanger
A
A
D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics* / Q000502:physiology*; D015096:3-Hydroxysteroid Dehydrogenases / Q000235:genetics* / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D001141:Aromatase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D055598:Chemical Phenomena; D002621:Chemistry; D005796:Genes; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
D012739:Gonadal Steroid Hormones; D007527:Isoenzymes; D015067:17-Hydroxysteroid Dehydrogenases; D015096:3-Hydroxysteroid Dehydrogenases; D001141:Aromatase