Selective dopamine D-1 receptor agonists, SK&F 38393 and CY 208-243 reduce sucrose sham-feeding in the rat.
Gastric-fistulated rats were trained to sham-feed a 10% sucrose solution in a 60 min test. The selective dopamine D-1 receptor agonists, SK&F 38393 (3 and 10 mg/kg, s.c.) and CY 208-243 (1 and 3 mg/kg, s.c.) both produced dose-related reductions in sham-feeding. These effects were present in the first 5 min of the test period, and persisted throughout the remainder of the test. The data confirm and extend results for an anorectic effect of SK&F 38393 and demonstrate, for the first time, a similar anorectic effect of CY 208-243.
Cooper
S J
SJ
Laboratory of Psychopharmacology, School of Psychology, University of Birmingham, U.K.
Francis
J
J
Barber
D J
DJ
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D010617:Phenanthridines / Q000494:pharmacology*; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D013395:Sucrose / Q000494:pharmacology
D001067:Appetite Depressants; D015259:Dopamine Agents; D007211:Indoles; D010617:Phenanthridines; D017447:Receptors, Dopamine D1; C054531:CY 208-243; D013395:Sucrose; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine