title: Influence of metal implants on infection. An experimental study in rabbits.
abstract: We implanted cylinders of cobalt-chrome or titanium, with smooth or porous surfaces, into rabbit bones which had been inoculated with suspensions of Staphylococcus aureus in various doses. The bacterial concentration required to produce infection of porous-coated titanium implants was 2.5 times smaller than that necessary to infect implants with polished surfaces. Porous-coated cobalt-chromium implants required bacterial concentrations that were 40 times smaller than those needed to infect implants with polished surfaces, and 15 times smaller than those required to infect porous-coated titanium implants. The other advantages and disadvantages of the various implants, such as improved osseointegration, larger ion-release surfaces, surface wear and relative stiffness, must be weighed against the higher infection rates in the porous-coated implants, and particularly in the cobalt-chromium implants.
authors.affiliation: La Paz Hospital, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cordero
authors.forename: L
authors.initials: L
authors.lastname: Munuera
authors.forename: M D
authors.initials: MD
authors.lastname: Folgueira
mesh_terms: D000818:Animals; D002858:Chromium Alloys; D004311:Double-Blind Method; D004866:Equipment Contamination; D005188:False Negative Reactions; D005189:False Positive Reactions; D006622:Hip Prosthesis / Q000009:adverse effects*; D008297:Male; D008954:Models, Biological; D019736:Prostheses and Implants; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000382:microbiology*; D011817:Rabbits; D011897:Random Allocation; D015203:Reproducibility of Results; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013499:Surface Properties; D014025:Titanium
chemical_list: D002858:Chromium Alloys; D014025:Titanium