[The individual chemosensitivity of the cells of urogenital tumors in vitro].
Individual chemosensitivity of 20 tumors from oncologic patients was determined by autoradiographic registration of the DNA synthesis inhibition by chemotherapeutics in tumor cells of primary tissue cultures grown in vitro between microscopic slides. Twelve renal carcinomas, 1 renal pelvis carcinoma, 5 urinary bladder carcinomas, 1 testicle teratoblastoma and 1 retroperitoneal space liposarcoma were tested. While the localization and histologic diagnoses were the same the tumors from various patients had strictly different sensitivity to chemotherapeutic drugs. Some tumors were even resistant to all the drugs tested. It was shown that the renal carcinomas had mainly low individual chemosensitivity. In 7 patients stimulation of the DNA synthesis under the action of the chemotherapeutics instead of its inhibition was observed.
Pashkova
V S
VS
Filippova
L A
LA
Lavrenov
A L
AL
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001345:Autoradiography; D002277:Carcinoma / Q000188:drug therapy* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008080:Liposarcoma / Q000188:drug therapy* / Q000378:metabolism; D013724:Teratoma / Q000188:drug therapy* / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014565:Urogenital Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm
Individual'naia khimiochuvstvitel'nost' kletok opukholeĭ mochepolovoĭ sistemy in vitro.