title: Perfusion with high potassium plus glutamate can cause LTP erasure or persistent loss of neuronal responsiveness in the CA1 region of the hippocampal slice.
abstract: Brief perfusion of salines containing elevated (10.5-50 mM) [K+] plus glutamate (2.5 or 5 mM) could erase long-term potentiation (LTP) in rat hippocampal slices. Prolonged perfusion with high-[K+]/glutamate could cause persistent neuronal depression lasting > 1 h. LTP erasure occurred in the absence of generalized depression of axonal responsiveness, while persistent neuronal depression was associated with a failure of antidromic invasion of cells. The protocols used may contribute to the development of a model for the cellular study of memory loss following neurological dysfunction.
authors.affiliation: Department of Anesthesiology, University of Maryland School of Medicine, Baltimore 21201.
authors.forename: C M
authors.initials: CM
authors.lastname: Harrison
authors.forename: B E
authors.initials: BE
authors.lastname: Alger
mesh_terms: D000818:Animals; D005971:Glutamates / Q000008:administration & dosage*; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008569:Memory Disorders / Q000139:chemically induced*; D009473:Neuronal Plasticity / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D010477:Perfusion; D011188:Potassium / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D011188:Potassium