Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein.
Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 kDa component identified in human platelets isolated from normal donors. Based on size, immunoreactivity and amino acid sequence analysis, the fragment is a C-terminal beta PP component which starts at position 642 (APP770 numbering) and contains the intact A beta sequence. The presence of this novel pathway of beta PP processing in resting platelets suggest that it occurs as a normal event.
Ghiso
J
J
Department of Pathology, New York University Medical Center, NY 10016.
Gardella
J E
JE
Liem
L
L
Gorevic
P D
PD
Frangione
B
B
D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis* / Q000276:immunology; D001792:Blood Platelets / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans
D016564:Amyloid beta-Protein Precursor