title: Langerhans cell histiocytosis in an adult.
abstract: We present the case of a 27-year-old Caucasian woman who suffered from Langerhans cell histiocytosis with axillary and scalp involvement. She also developed diabetes insipidus after 2 years of skin lesions. Topical nitrogen mustard therapy was performed for the skin lesions, but we had to stop this therapy because of severe local irritation and systemic urticaria. Afterwards, we administered etoposide systemically, but no improvement appeared in 6 weeks. Finally we used methotrexate for 3 months and the result was very good at the end of the first month.
authors.affiliation: Department of Pathology, GATA Teaching Hospital, Haydarpaşa, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Sayrak
authors.forename: B
authors.initials: B
authors.lastname: Doğan
authors.forename: Y
authors.initials: Y
authors.lastname: Harmanyeri
authors.forename: I
authors.initials: I
authors.lastname: Oztek
authors.forename: H
authors.initials: H
authors.lastname: Cingil
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001365:Axilla; D003919:Diabetes Insipidus / Q000150:complications; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage; D008727:Methotrexate / Q000627:therapeutic use; D012535:Scalp
chemical_list: D008466:Mechlorethamine; D005047:Etoposide; D008727:Methotrexate