The ACTH-(4-9) analog, ORG 2766, prevents taxol-induced neuropathy in rats.
Taxol is a novel and promising oncolytic agent the use of which is hampered by its neurotoxicity. We now describe a taxol-induced neuropathy in rats and its prevention by the adrenocorticotropic hormone-(4-9) (ACTH-(4-9)) analog, ORG 2766. A decrease in sensory nerve conduction velocity was seen in taxol-treated rats, both with daily injections of small amounts (6 mg/kg per week) and with weekly injections of higher amounts (9 mg/kg per week) of taxol. Concomitant administration of ORG 2766 completely prevented the occurrence of a neuropathy.
Hamers
F P
FP
Department of Medical Pharmacology, Rudolf Magnus Institute, Medical Faculty Utrecht University, Netherlands.
Pette
C
C
Neijt
J P
JP
Gispen
W H
WH
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects; D017239:Paclitaxel / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone; D017239:Paclitaxel