title: Maternal mild hyperphenylalaninemia: results of treated and untreated pregnancies in two sisters.
abstract: The outcomes of mild hyperphenylalaninemia (MHP) in three children of two sisters were compared. The IQ of the child from an untreated pregnancy was 105; the developmental quotients of the two infant offspring from treated and untreated pregnancies were 122 and 114, respectively. The IQ of the sister with untreated MHP was 101; that of the sister who received dietary treatment for MHP during infancy was 90. Thus MHP and maternal MHP appear to have been clinically inconsequential in this family.
authors.affiliation: Department of Nutrition and Medical Dietetics, University of Illinois at Chicago.
authors.forename: H L
authors.initials: HL
authors.lastname: Levy
authors.forename: B S
authors.initials: BS
authors.lastname: Goss
authors.forename: D K
authors.initials: DK
authors.lastname: Sullivan
authors.forename: K
authors.initials: K
authors.lastname: Michals-Matalon
authors.forename: J M
authors.initials: JM
authors.lastname: Dobbs
authors.forename: P
authors.initials: P
authors.lastname: Guldberg
authors.forename: F
authors.initials: F
authors.lastname: Güttler
mesh_terms: D000328:Adult; D002657:Child Development; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence / Q000235:genetics; D008297:Male; D010649:Phenylalanine / Q000097:blood* / Q000235:genetics; D010661:Phenylketonurias / Q000097:blood / Q000178:diet therapy / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications
chemical_list: D010649:Phenylalanine