title: [Effects of diltiazem hydrochloride on blood gases].
abstract: The effects of diltiazem, Ca ion channel blocker, on arterial blood gases were evaluated in 50 patients (G-I: 24 patients undergoing abdominal surgery, G-II: 26 patients undergoing non-abdominal surgery). Diltiazem hydrochloride was administered to prevent intraoperative hypertension as a bolus (5 mg) followed by a continuous infusion (5-10 micrograms.kg-1.min-1). Arterial blood gases were analyzed just before, as well as 5 and 15 min after the administration of diltiazem. In G-I, arterial blood oxygen tension decreased significantly (P < 0.001) from 210.8 +/- 42.4 to 197.7 +/- 50.2 mmHg 5 min after infusion, and to 193.2 +/- 53.4 mmHg 15 min after; while there was no significant difference in G-II. Diltiazem infusion may deteriorate oxygenation in patients undergoing abdominal surgery, and therefore oxygenation should be carefully monitored.
authors.affiliation: Department of Anesthesiology, University of Tokushima School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Kitahata
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Kawahito
authors.forename: A
authors.initials: A
authors.lastname: Kohyama
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D004110:Diltiazem / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure
chemical_list: D004110:Diltiazem; D010100:Oxygen