Putting together an MHC class I molecule.
Formation of MHC class I complexes involves proper folding of the subunits, their assembly and interaction with peptides. Several proteins contributing to this process have been described, but a number of questions remain, in particular those concerning early folding steps and interactions with peptide in the course of biosynthesis.
Bijlmakers
M J
MJ
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge.
Ploegh
H L
HL
D000818:Animals; D018833:Chaperonins; D005787:Gene Frequency; D015789:HLA-A2 Antigen / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D051379:Mice; D010455:Peptides / Q000378:metabolism; D011487:Protein Conformation; D017510:Protein Folding; D021382:Protein Sorting Signals / Q000502:physiology; D011506:Proteins / Q000378:metabolism
D015789:HLA-A2 Antigen; D015395:Histocompatibility Antigens Class I; D010455:Peptides; D021382:Protein Sorting Signals; D011506:Proteins; D018833:Chaperonins