title: Alzheimer disease: an imbalance of proteolytic regulation?
abstract: Alzheimer disease is typified by the accumulation of protein and neuronal death. We propose that neuronal death creates a proteolytic imbalance that generates the pathological lesions. Our hypothesis explains the morphology and topographic distribution of neuritic plaques and neurofibrillary tangles.
authors.affiliation: Division of Neuropathology, Case Western Reserve University, Cleveland, OH 44106-4901.
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Perry
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D016923:Cell Death; D010450:Endopeptidases / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D016501:Neurites / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000378:metabolism
chemical_list: D010450:Endopeptidases