Current status of gene transfer into haemopoietic progenitor cells: application to Langerhans cell histiocytosis.
A number of recent studies have shown that it is possible to obtain significant levels of gene transfer and expression in marrow progenitor cells and their progeny by using retroviral vectors. The data obtained from these studies and the possible applications to Langerhans cell histiocytosis (LCH) are reviewed.
Brenner
M
M
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.
D018014:Gene Transfer Techniques; D005819:Genetic Markers; D005822:Genetic Vectors; D006412:Hematopoietic Stem Cells; D006646:Histiocytosis, Langerhans-Cell / Q000628:therapy*; D006801:Humans; D012106:Research; D012190:Retroviridae / Q000235:genetics
D005819:Genetic Markers