title: [Increased fibrinolytic activity during cardiopulmonary bypass is caused by activated protein C system].
abstract: To examine the hypothesis that activated protein C system during cardiopulmonary bypass surgery may increase fibrinolytic activity during cardiopulmonary bypass, protein C activity, protein C antigen and thrombomodulin of sixteen patients undergoing elective cardiopulmonary bypass surgery were investigated after induction of anesthesia, before and after cardiopulmonary bypass, and at the end of operation. Protein C activity decreased and thrombomodulin increased significantly after the cardiopulmonary bypass. There were no significant correlations of thrombomodulin with protein C activity and protein C antigen. In conclusion, we have demonstrated that protein C system is activated and circulating thrombomodulin appears in the systemic circulation during cardiopulmonary bypass surgery and this enhanced activation of protein C system is possibly related to the reported increase of fibrinolytic activity during cardiopulmonary bypass.
authors.affiliation: Department of Emergency and Critical Care Medicine, Sapporo City General Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Gando
authors.forename: I
authors.initials: I
authors.lastname: Tedo
authors.forename: H
authors.initials: H
authors.lastname: Masio
authors.forename: Y
authors.initials: Y
authors.lastname: Goda
authors.forename: H
authors.initials: H
authors.lastname: Kawahigashi
mesh_terms: D000758:Anesthesia; D002315:Cardiopulmonary Bypass; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*; D018180:Thrombomodulin / Q000378:metabolism*
chemical_list: D011486:Protein C; D018180:Thrombomodulin