title: Testosterone modulates mesolimbic dopaminergic activity in male rats.
abstract: Male rats were castrated before puberty. When they were adult, the activity of their mesolimbic dopamine system was tested by ventral striatum microdialysis. Amphetamine injections increased dopamine more in castrated rats than in normal rats. This exaggerated response was attenuated by testosterone replacement therapy. The mechanism by which androgens modulate the activity of the mesolimbic dopamine system is discussed.
authors.affiliation: Laboratory of Behavioral Physiology, Los Andes University, Venezuela.
authors.forename: L
authors.initials: L
authors.lastname: Hernandez
authors.forename: L
authors.initials: L
authors.lastname: Gonzalez
authors.forename: E
authors.initials: E
authors.lastname: Murzi
authors.forename: X
authors.initials: X
authors.lastname: Páez
authors.forename: E
authors.initials: E
authors.lastname: Gottberg
authors.forename: T
authors.initials: T
authors.lastname: Baptista
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism*; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009919:Orchiectomy; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000502:physiology*
chemical_list: D013739:Testosterone; D000661:Amphetamine; D004298:Dopamine