Effect of age and streptozocin concentration on the induction by streptozocin of hyperglycaemia in fasting rats.
The effect of age and streptozocin concentration on the induction by streptozocin of hyperglycaemia in fasting rats is investigated. The data show that there is a dose dependent effect of streptozocin on the hyperglycaemia induced by streptozocin, and 60 mg/kg streptozocin is significantly more effective than 20 or 40 mg/kg streptozocin in inducing hyperglycaemia. Moreover, the hyperglycaemia induced by 60 mg/kg streptozocin is greater in 8 week old rats than in 4 or 6 week old rats, suggesting an influence of age on streptozocin-induced hyperglycaemia.
Wong
K K
KK
Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China.
Wu
H M
HM
D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005215:Fasting; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced*; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000633:toxicity*
D001786:Blood Glucose; D013311:Streptozocin; D006003:Glycogen