title: Gastric bicarbonate secretion in high-relapsing, smoking duodenal ulcer patients.
abstract: Gastric bicarbonate secretion has been evaluated by Feldman's method in 48 duodenal-ulcer patients. The relationship between smoking, clinical ulcer outcome (healing and recurrence) and bicarbonate secretion has been analysed. Heavy smokers secreted higher bicarbonate ions than did non-smokers. High-relapsing patients produced lower bicarbonate output. These preliminary data suggest that an impaired gastric bicarbonate secretion is associated with smoking, a well-known ulcer-associated factor; further-more, it may single out high-relapsing duodenal ulcer patients.
authors.affiliation: Istituto di Medicina Interna, Università degli Studi di Padova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Dal Santo
authors.forename: F
authors.initials: F
authors.lastname: Vianello
authors.forename: B
authors.initials: B
authors.lastname: Germana
authors.forename: T
authors.initials: T
authors.lastname: Del Bianco
authors.forename: G
authors.initials: G
authors.lastname: Laino
authors.forename: S A
authors.initials: SA
authors.lastname: Grassi
authors.forename: M
authors.initials: M
authors.lastname: Plebani
authors.forename: P
authors.initials: P
authors.lastname: Dotto
authors.forename: G
authors.initials: G
authors.lastname: Battaglia
authors.forename: F
authors.initials: F
authors.lastname: Di Mario
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology / Q000503:physiopathology*
chemical_list: D001639:Bicarbonates; D006635:Histamine H2 Antagonists