Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.
Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.
Berrettini
W H
WH
Department of Psychiatry and Human Behavior, Jefferson Cancer Institute, Philadelphia, Pennsylvania.
Ferraro
T N
TN
Alexander
R C
RC
Buchberg
A M
AM
Vogel
W H
WH
D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004276:DNA, Satellite; D004327:Drinking Behavior; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics* / Q000502:physiology; D008811:Mice, Inbred DBA / Q000235:genetics* / Q000502:physiology; D009021:Morphine Dependence / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction
D004276:DNA, Satellite