title: Human serum resistant promastigotes of Leishmania infantum in the midgut of Phlebotomus perniciosus.
abstract: Promastigotes of Leishmania infantum develop from early-stage normal human serum (nHS) sensitive forms to a partially nHS resistant stage in the midgut of Phlebotomus perniciosus. This development begins about day 7 after the sandfly has taken its initial infective bloodmeal. The onset of partial nHS-resistance occurs when mass proliferation of midgut promastigotes is already completed and the parasites have begun to differentiate into small, highly motile cells. In this parasite/vector interrelationship, the stomodeal valve seems to be a barrier which limits the development of L. infantum in P. perniciosus to the midgut.
authors.affiliation: Swiss Tropical Institute, Basel.
authors.forename: F
authors.initials: F
authors.lastname: Grimm
authors.forename: L
authors.initials: L
authors.lastname: Jenni
mesh_terms: D000818:Animals; D004064:Digestive System / Q000469:parasitology; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007303:Insect Vectors / Q000469:parasitology*; D007893:Leishmania donovani / Q000254:growth & development* / Q000276:immunology; D010691:Phlebotomus / Q000469:parasitology*; D013997:Time Factors
chemical_list: D007106:Immune Sera