title: Structural analysis of c-myc in human sporadic colorectal carcinomas.
abstract: Analysis of the DNA extracted from the colonic mucosa of 13 patients operated for colorectal carcinoma revealed c-myc rearrangements in three of them. In all cases, the alterations were found both in the histologically normal and in the tumoral mucosa. In one case, a different pattern of rearrangements characterized the two tissues. In all three individuals, the c-myc sequences appeared to be amplified. We suggest that c-myc rearrangements in the histologically normal colonic mucosa of colorectal carcinoma patients could represent a predisposition factor for the development of additional neoplasms.
authors.affiliation: Dipartimento di Biologia Cellulare e dello Sviluppo, University of Palermo, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Albanese
authors.forename: M
authors.initials: M
authors.lastname: Alberti
authors.forename: V
authors.initials: V
authors.lastname: Bazan
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: S
authors.initials: S
authors.lastname: Baiamonte
authors.forename: M
authors.initials: M
authors.lastname: Migliavacca
authors.forename: P
authors.initials: P
authors.lastname: Bazan
authors.forename: M
authors.initials: M
authors.lastname: La Farina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies