[Effects of inhaled beta-adrenergic and anticholinergic drugs on respiratory function and arterial blood gases in patients with pulmonary emphysema].
We studied the effects of inhaled anticholinergic (oxitropium bromide, 0.2 mg) and beta-adrenergic (fenoterol 0.4 mg) drugs on respiratory function and arterial blood gases in fourteen male patients with pulmonary emphysema (age 63 +/- 8 years; FEV1/FVC 1.41 +/- 0.73 L) using a three day, randomized, double-blind placebo-controlled design. Each day, spirometry and arterial blood gas analyses were performed before and 45 min after inhalation. Both fenoterol and oxitropium bromide significantly improved FEV1 by 21% and 16%, respectively, although there was no significant difference between the two drugs. However, the mean value of PaO2 significantly decreased from 74.5 +/- 2.6 to 69.3 +/- 2.7 Torr with fenoterol, but not with oxitropium and placebo. Change of PaO2 with fenoterol was significantly correlated with %FRC, but not with FEV1 nor change of FEV1. We therefore conclude that an anticholinergic inhalant bronchodilator is more favorable for patients with COPD than a beta-adrenergic agent.
Igarashi
T
T
First Department of Medicine, Hokkaido University School of Medicine.
Nishimura
M
M
Akiyama
Y
Y
Yamamoto
M
M
Kobayashi
S
S
Miyamoto
K
K
Kawakami
Y
Y
D000318:Adrenergic beta-Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D005280:Fenoterol / Q000494:pharmacology / Q000627:therapeutic use; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010276:Parasympatholytics / Q000494:pharmacology* / Q000627:therapeutic use; D010313:Partial Pressure; D011656:Pulmonary Emphysema / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D012602:Scopolamine Derivatives / Q000494:pharmacology / Q000627:therapeutic use
D000318:Adrenergic beta-Agonists; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; D005280:Fenoterol; C017590:oxitropium; D010100:Oxygen