title: Influence of the sterilization process on alginate dispersions.
abstract: The influence of different sterilization procedures on alginate dispersions was studied by measuring viscosity and molecular weight changes. Autoclaving caused a 64% decrease in viscosity. Heating at a low temperature over several cycles was less efficient in sterilizing alginates and there was a progressive breakdown of the alginate chain over the succeeding cycles. Heating during ethylene oxide sterilization also resulted in reduced viscosity and breakdown. Membrane filtration yielded a sterile product with no significant reduction in viscosity or mol. wt.
authors.affiliation: Laboratory of Pharmaceutical Technology, University of Ghent, Belgium.
authors.forename: G M
authors.initials: GM
authors.lastname: Vandenbossche
authors.forename: J P
authors.initials: JP
authors.lastname: Remon
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001709:Biotechnology / Q000379:methods; D002850:Chromatography, Gel; D005027:Ethylene Oxide; D008970:Molecular Weight; D013242:Sterilization / Q000379:methods; D014783:Viscosity
chemical_list: D000464:Alginates; D005027:Ethylene Oxide