Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.
We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
Fest
T
T
Service de Médecine Interne et d'Immunologie Clinique, CHU Jean Minjoz, Besançon, France.
de Wazières
B
B
Lamy
B
B
Maskani
M
M
Vuitton
D
D
Dupond
J L
JL
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology / Q000628:therapy*; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006384:Hemagglutination; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D011994:Recombinant Proteins
D001323:Autoantibodies; D006454:Hemoglobins; D007075:Immunoglobulin M; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins