Attention-deficit hyperactivity disorder: magnetic resonance imaging morphometric analysis of the corpus callosum.
OBJECTIVE
The following study seeks to document possible differences in corpus callosal area and shape between children with attention-deficit hyperactivity disorder (ADHD) and controls.


METHODS
Fifteen carefully diagnosed right-handed male subjects with ADHD with overactivity symptomatology were compared to 15 right-handed male control subjects. The corpus callosum was divided into seven areas on the midsagittal slice of a magnetic resonance image with shape analysis also conducted.


RESULTS
An exploratory shape analysis showed no significant differences in shape between the groups. No group differences were found in the area, length, or anterior regions of the corpus callosum. The ADHD subjects were found to have significantly smaller posterior corpus callosum regions than the control group, with the splenium accounting for most of the variance between the groups.


CONCLUSIONS
The splenial area of the corpus callosum is smaller in children with ADHD than in a sample of normally developing children. These smaller areas may relate to commonly seen sustained attention deficits which in turn negatively impact on the development of more advanced levels of attention such as self-regulation. Further study of the regions surrounding the splenial area is suggested to determine whether they are correlated in size to the smaller corpus callosum.
Semrud-Clikeman
M
M
University of Washington, Seattle 98195.
Filipek
P A
PA
Biederman
J
J
Steingard
R
R
Kennedy
D
D
Renshaw
P
P
Bekken
K
K
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002648:Child; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D003891:Desipramine / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D011859:Radiography
D008774:Methylphenidate; D003891:Desipramine