An early haematopoietic defect in mice lacking the transcription factor GATA-2.
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.
Tsai
F Y
FY
Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts.
Keller
G
G
Kuo
F C
FC
Weiss
M
M
Chen
J
J
Rosenblatt
M
M
Alt
F W
FW
Orkin
S H
SH
D000740:Anemia / Q000196:embryology; D000818:Animals; D001483:Base Sequence; D001853:Bone Marrow / Q000196:embryology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D005313:Fetal Death; D050989:GATA2 Transcription Factor; D005786:Gene Expression Regulation; D005804:Genes, Lethal; D006410:Hematopoiesis / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016296:Mutagenesis; D015183:Restriction Mapping; D013154:Spleen / Q000166:cytology / Q000196:embryology; D013234:Stem Cells; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D017931:DNA Primers; D004268:DNA-Binding Proteins; D050989:GATA2 Transcription Factor; C494712:Gata2 protein, mouse; D014157:Transcription Factors