title: Coagulopathy with piperacillin administration in cystic fibrosis: two case reports.
abstract: Two cases are reported of coagulopathy in association with the administration of piperacillin to patients with cystic fibrosis. In both cases the coagulopathy was associated with the development of a serum sickness-like illness with fever, rash and abnormal liver function tests occurring on day 12 and day 16 of treatment, respectively. On withdrawal of the piperacillin, both the serum sickness and the coagulopathy resolved rapidly, without sequelae.
authors.affiliation: Department of Pulmonary Medicine, Adelaide Children's Hospital, North Adelaide, Australia.
authors.forename: P J
authors.initials: PJ
authors.lastname: Rye
authors.forename: G
authors.initials: G
authors.lastname: Roberts
authors.forename: R E
authors.initials: RE
authors.lastname: Staugas
authors.forename: A J
authors.initials: AJ
authors.lastname: Martin
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000139:chemically induced*; D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000188:drug therapy*; D003875:Drug Eruptions / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D010878:Piperacillin / Q000009:adverse effects*; D012713:Serum Sickness / Q000097:blood / Q000139:chemically induced*
chemical_list: D010878:Piperacillin