[Modulation of Na pump in proximal kidney tubules cells of the rat].
The present paper shows evidence indicating that one of the active mechanisms of sodium extrusion shown to be present in basolateral plasma membranes of the proximal tubular cells of mammalian kidney, the Na-pump (which extrudes sodium from the cells accompanied by chloride and water), is modulated in its activity by the cell volume. An increase of the cell volume, produces a concomitant increase of the activity of the Na-pump. On the other hand, the activity of the Na, K-pump, which extrudes sodium from the cells in exchange for potassium, is totally independent of the cell volume. The modulating effect of the cell volume on the activity of the Na-pump, can be either demonstrated under "in vitro" or "in vivo" conditions.
Proverbio
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Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas.
Marín
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D000818:Animals; D001834:Body Water / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology; D004909:Erythrocyte Indices / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011189:Potassium Chloride / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D011189:Potassium Chloride; D000254:Sodium-Potassium-Exchanging ATPase
Modulación de la bomba de Na en células de túbulo proximal de riñón de rata.