title: Hematopoietic elements associated with adrenal glands. A study of the spectrum of change in nine cases.
abstract: We report nine cases of hematopoietic elements or myelolipomatous foci that were found in association with normal and neoplastic adrenal glands. A spectrum of change occurred that ranged from small clusters of purely erythroid or myeloid cells to microscopic myelolipomas that contained a mixture of hematopoietic elements. Recognition of the myeloid elements was facilitated with the use of the chloroacetate esterase (Leder) stain and a CD15 (myelomonocytic antigen) immunohistochemical stain. The majority (six of nine) of these cases were found in association with cortical adenomas in middle-aged women, but myelolipomatous foci were also found in association with an adrenocortical carcinoma, a pheochromocytoma, and a renal angiomyolipoma. The histogenesis of the foci remained speculative. However, the association with hormonally active neoplasms suggested that the hormonal microenvironment may have played a role in the development of the myelolipomatous foci.
authors.affiliation: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242-1009.
authors.forename: S P
authors.initials: SP
authors.lastname: Goetz
authors.forename: T H
authors.initials: TH
authors.lastname: Niemann
authors.forename: R A
authors.initials: RA
authors.lastname: Robinson
authors.forename: M B
authors.initials: MB
authors.lastname: Cohen
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D018246:Adrenocortical Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018209:Myelolipoma / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*