title: Rectal indomethacin for analgesia after appendicectomy in children.
abstract: A prospective randomised controlled trial comparing rectal indomethacin with placebo was performed in children. Thirty children aged seven years and over undergoing open appendicectomy were given suppositories of either indomethacin 2 mg/kg or placebo. Suppositories were given at the conclusion of surgery and again 12 and 24 hours later. All children were given morphine by a patient-controlled analgesia pump. After 36 hours, children given indomethacin had used 0.51 (SD 0.34) mg/kg, and children given placebo 0.91 (SD 0.46) mg/kg (P < 0.02). Pain scores measured with a visual analogue scale, sedation scores and the incidence of vomiting were similar in both groups. Children given indomethacin suppositories used 44% less morphine than children given placebo, and at the same time obtained similar postoperative analgesia.
authors.affiliation: Department of Anaesthesia, Princess Margaret Hospital for Children, Perth, W.A.
authors.forename: C
authors.initials: C
authors.lastname: Sims
authors.forename: C M
authors.initials: CM
authors.lastname: Johnson
authors.forename: R
authors.initials: R
authors.lastname: Bergesio
authors.forename: S J
authors.initials: SJ
authors.lastname: Delfos
authors.forename: E A
authors.initials: EA
authors.lastname: Avraamides
mesh_terms: D000285:Administration, Rectal; D000698:Analgesia; D016058:Analgesia, Patient-Controlled; D001062:Appendectomy / Q000009:adverse effects*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007260:Infusion Pumps; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D008787:Metoclopramide / Q000627:therapeutic use; D009020:Morphine / Q000008:administration & dosage; D010149:Postoperative Pain / Q000517:prevention & control*; D010919:Placebos; D011446:Prospective Studies; D013488:Suppositories; D013997:Time Factors; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control
chemical_list: D010919:Placebos; D013488:Suppositories; D009020:Morphine; D008614:Meperidine; D008787:Metoclopramide; D007213:Indomethacin