title: Amyloid bone disease and highly permeable synthetic membranes.
abstract: The effect of different highly permeable membranes on amyloid bone disease (ABD) was retrospectively evaluated in patients on renal replacement therapy (RRT) in our Unit with a dialytic age of more than 4 years. A group of 36 patients (age 60 +/- 12 years) after a variable period (28 +/- 29 months) on hemodialysis with cuprophane membrane (CU-HD), were moved to HDF with a reinfusate volume of 22 +/- 1 1/session, for a period of 65 +/- 26 months using the following membranes: AN69 1.6 m2, PAN 1.8, PMMA 2.1, PS 1.3, polyamide (PA) 1.3 and 1.6. Bone x-rays of wrists, hips and shoulders were taken annually and the presence of ABD was evaluated according to generally accepted criteria. ABD occurred in 4 patients after a period of 73 +/- 30 months on CU-HD only; it developed in 4/7 patients an AN69, in 4/6 on PAN, in 3/5 on PMMA, in 3/5 on PS; no patient of the 13 on PA developed ABD. Comparing patients on PA with those on other synthetic membranes, no significant difference was found in dialysis time (73 +/- 19 vs 83 +/- 28 months) as well as in age (59 +/- 13 vs 61 +/- 11 years) at ABD on set, when present. These data strongly encourage prospective studies enrolling more patients for a longer period of observation in order to evaluate possible differences on ABD development among various synthetic membranes.
authors.affiliation: Service of Radiology, General Hospital, Casale Monferrato, AL, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Boccalatte
authors.forename: G
authors.initials: G
authors.lastname: Pratesi
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: A
authors.initials: A
authors.lastname: Bignazzi
authors.forename: M
authors.initials: M
authors.lastname: Gonella
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010539:Permeability; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation; D012189:Retrospective Studies
chemical_list: D008567:Membranes, Artificial