Obstructive nephropathy: from mechanical disturbance to immune activation?
Acute obstructive uropathy is a major cause of renal impairment world-wide and leads to end-stage renal failure if left untreated. It is now clear that obstructive nephropathy is not simply a mechanical impairment to urine flow but a complex syndrome resulting in the alteration in both glomerular haemodynamics and tubular function. This appears to result from the interactions of a variety of vasoactive factors and cytokines which are activated as a result of an obstruction in the urinary tract. A hitherto unrecognized leukocyte infiltrate appears to play a key role in such alterations in renal function, suggesting that ureteral obstruction should now be considered to have an immunological component.
Harris
K P
KP
Department of Nephrology, Leicester General Hospital, UK.
Klahr
S
S
Schreiner
G
G
D000804:Angiotensin II / Q000502:physiology; D001696:Biomechanical Phenomena; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D007684:Kidney Tubules / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology; D008954:Models, Biological; D012079:Renal Circulation / Q000502:physiology; D013928:Thromboxane A2 / Q000502:physiology; D014517:Ureteral Obstruction / Q000150:complications* / Q000276:immunology / Q000503:physiopathology
D016207:Cytokines; D000804:Angiotensin II; D013928:Thromboxane A2