title: The effect of zidovudine on neuropsychiatric measures in HIV-infected men.
abstract: The authors examined the effects of zidovudine on neuropsychiatric measures, at three assessment points separated by 6 months, in 25 HIV-positive men who took zidovudine for at least 6 months and a comparison group of 25 HIV-positive men with similar CD4+ T cell counts who had never taken zidovudine. Zidovudine had no statistically significant effect except for a slight improvement in Global Assessment of Functioning scale score. In this small group of subjects there was little benefit but also little evidence of CNS toxicity from zidovudine.
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, NY 10032.
authors.forename: J M
authors.initials: JM
authors.lastname: Gorman
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: J B
authors.initials: JB
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Rabkin
authors.forename: R R
authors.initials: RR
authors.lastname: Goetz
authors.forename: A A
authors.initials: AA
authors.lastname: Ehrhardt
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009483:Neuropsychological Tests; D015215:Zidovudine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D015215:Zidovudine