Tyr-MIF-1 precipitates abstinence syndrome in morphine-dependent rats.
The endogenous neuropeptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide) has been shown to counteract various opiate actions. In the current study, third ventricular injection of 35 micrograms Tyr-MIF-1 protected by the enzyme inhibitor bestatin precipitated an abstinence syndrome in morphine-dependent rats, but not in opiate-naive rats. The results raise the possibility that Tyr-MIF-1 might participate in opiate dependence and opiate abstinence syndrome.
Malin
D R
DR
University of Houston-Clear Lake, TX 77058.
Zadina
J E
JE
Lake
J R
JR
Rogillio
R B
RB
Leyva
J E
JE
Benson
T M
TM
Corriere
L S
LS
Handunge
B P
BP
Kastin
A J
AJ
D000818:Animals; D006801:Humans; D007231:Infant, Newborn; D009075:MSH Release-Inhibiting Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D009021:Morphine Dependence; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D009020:Morphine; C036930:tyrosyl-prolyl-leucyl-glycinamide; D009075:MSH Release-Inhibiting Hormone