title: Mapping of the X linked form of hyper IgM syndrome (HIGM1)
abstract: X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.
authors.affiliation: Molecular Genetics Unit, Institute of Child Health, London.
authors.forename: M
authors.initials: M
authors.lastname: Padayachee
authors.forename: R J
authors.initials: RJ
authors.lastname: Levinsky
authors.forename: C
authors.initials: C
authors.lastname: Kinnon
authors.forename: A
authors.initials: A
authors.lastname: Finn
authors.forename: C
authors.initials: C
authors.lastname: McKeown
authors.forename: C
authors.initials: C
authors.lastname: Feighery
authors.forename: L D
authors.initials: LD
authors.lastname: Notarangelo
authors.forename: R W
authors.initials: RW
authors.lastname: Hendriks
authors.forename: A P
authors.initials: AP
authors.lastname: Read
authors.forename: S
authors.initials: S
authors.lastname: Malcolm
mesh_terms: D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D004277:DNA, Single-Stranded / Q000737:chemistry; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics*; D007075:Immunoglobulin M; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010375:Pedigree; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013577:Syndrome; D014960:X Chromosome
chemical_list: D004277:DNA, Single-Stranded; D005819:Genetic Markers; D007075:Immunoglobulin M; D015345:Oligonucleotide Probes