title: Structural evolution of the annexin supergene family.
abstract: The annexin family of calcium-binding proteins is comprised of at least ten mammalian genes, with additional representatives in lower eukaryotes. Recent structural analyses of several annexin genes have provided insights into the relationship between exon organization and functional domains. We discuss the implications of these findings and speculate on the evolutionary origins of the annexin supergene family.
authors.affiliation: Department of Physiology, University College London, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Smith
authors.forename: S E
authors.initials: SE
authors.lastname: Moss
mesh_terms: D000595:Amino Acid Sequence; D017302:Annexins / Q000235:genetics*; D005075:Biological Evolution; D008969:Molecular Sequence Data; D005810:Multigene Family; D016415:Sequence Alignment
chemical_list: D017302:Annexins