title: The ancient regulatory-protein family of WD-repeat proteins.
abstract: WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: E J
authors.initials: EJ
authors.lastname: Neer
authors.forename: C J
authors.initials: CJ
authors.lastname: Schmidt
authors.forename: R
authors.initials: R
authors.lastname: Nambudripad
authors.forename: T F
authors.initials: TF
authors.lastname: Smith
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000502:physiology; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D015293:Transducin / Q000737:chemistry; D044844:beta-Transducin Repeat-Containing Proteins
chemical_list: C471644:BTRC protein, human; D011506:Proteins; D044844:beta-Transducin Repeat-Containing Proteins; D019204:GTP-Binding Proteins; D015293:Transducin