title: The use of dopexamine hydrochloride to increase oxygen delivery perioperatively.
abstract: Perioperative increases in oxygen delivery may reduce morbidity and mortality in certain groups of surgical patients. However positive inotropic drugs, such as dobutamine and epinephrine themselves, may increase oxygen demand. Dopexamine hydrochloride is a new dopamine analogue with action at beta 2-adrenoceptors and DA1 receptors, but it possesses no direct alpha-adrenoceptor activity. We assessed the suitability of dopexamine to increase oxygen delivery perioperatively in eight patients having vascular surgery and studied its effects on oxygen demand. Oxygen delivery was increased toward 600 mL.min-1.m-2 by intravenous (IV) fluid infusion and IV titration of dopexamine hydrochloride. Oxygen delivery could be increased preoperatively (375 +/- 43 to 552 +/- 50 mL.min-1.m-2, P < 0.05) with > 600 mL.min-1.m-2 being achieved in five patients. This increase was achieved without significant increase in total body oxygen consumption (114 +/- 10 to 123 +/- 7 mL.min-1.m-2 P > 0.05) or rate pressure product (13.7 +/- 2.8 x 10(3) to 13.5 +/- 2.1 x 10(3) mm Hg.beats/min, P > 0.05). Postoperatively oxygen delivery was increased again without an increase in oxygen consumption (126 +/- 10 mL.min-1.m-2, P > 0.05) or rate pressure product (14.2 +/- 0.9 x 10(3) mm Hg.beats/min, P > 0.05). Dopexamine hydrochloride may provide a method for increasing oxygen delivery perioperatively with only limited increase in total body or myocardial oxygen demand.
authors.affiliation: General Intensive Care Unit, St. George's Hospital, London, United Kingdom.
authors.forename: O
authors.initials: O
authors.lastname: Boyd
authors.forename: R M
authors.initials: RM
authors.lastname: Grounds
authors.forename: E D
authors.initials: ED
authors.lastname: Bennett
mesh_terms: D000322:Adrenergic Agonists / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D004298:Dopamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D014656:Vascular Surgical Procedures
chemical_list: D000322:Adrenergic Agonists; C046318:dopexamine; D010100:Oxygen; D004298:Dopamine