[Effects of allopurinol on uric acid metabolism and lipid peroxidation in ischemic heart disease patients with stable angina].
The study was undertaken to examine 20 healthy individuals and 60 IHD patients with stable angina of various functional classes. All the examinees were males. By the random sampling method, all the patients were divided into 2 groups: (1) 30 were on erinit and (2) 30 on erinit and allopurinol in conventional therapeutical doses. The level of uric acid in the serum and daily urine, lipid peroxidation, the antioxidative system and central hemodynamics were examined in all the examinees. The examination was performed on admission and every 10-14 days of their hospital stay. A combined therapy with erinit and allopurinol led to a significant decrease in serum and daily urinary levels of uric acid and lipid peroxidation antioxidative system and an improvement of central hemodynamics. It is concluded that it is useful to include allopurinol into the combined therapy for IHD patients with stable angina.
Kaliakin
I E
IE
Mit'kin
A F
AF
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000494:pharmacology*; D000787:Angina Pectoris / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010417:Pentaerythritol Tetranitrate / Q000008:administration & dosage; D014527:Uric Acid / Q000378:metabolism*
D010417:Pentaerythritol Tetranitrate; D014527:Uric Acid; D000493:Allopurinol
Vliianie allopurinola na obmen mochevoĭ kisloty i perekisnoe okislenie lipidov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa so stabil'noĭ stenokardieĭ.