title: Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.
abstract: Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage of breast and breast-ovarian cancers is significant in France and supports the existence of more than one susceptibility gene.
authors.affiliation: Unité d'Oncologie Génétique, Centre Léon Bérard, Lyons, France.
authors.forename: S
authors.initials: S
authors.lastname: Mazoyer
authors.forename: P
authors.initials: P
authors.lastname: Lalle
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
authors.forename: Y J
authors.initials: YJ
authors.lastname: Bignon
authors.forename: F
authors.initials: F
authors.lastname: Courjal
authors.forename: B
authors.initials: B
authors.lastname: Jamot
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
authors.forename: D
authors.initials: D
authors.lastname: Stoppa-Lyonnett
authors.forename: H
authors.initials: H
authors.lastname: Sobol
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D016009:Chi-Square Distribution; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D005192:Family Health; D005260:Female; D005602:France; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes
chemical_list: D005819:Genetic Markers