Effect of Aspergillus terreus extract on neoplastic and non-neoplastic cell replication.
There are very few and unconfirmed data regarding the antineoplastic activity of mycotic derivates in human cells. The effects on neoplastic and non-neoplastic cell replication of Aspergillus terreus extracts have been tested. In fact, among different species of Aspergillus mycotoxin producers. A terreus seems to be more suitable for hypothetical therapeutic purposes because of its low mycotoxin toxicity. Very evident antiblastic activity of alcoholic crude extract of A. terreus on tumor cells has been demonstrated. Doses between 3.1 and 6.2 inhibited more than 50% of tumor cells; the same effect was obtained with doses > 25 micrograms/ml on non-neoplastic cells. The action of the crude extract does not influence cellular cAMP in either neoplastic or non-neoplastic cells. The antiblastic action seems to depend primarily on the inhibitory effect of DNA duplication. Some chromatographed fractions of the mycotic extract showed inhibiting or enhancing effects on cell growth.
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Istituto Malattie Infettive Università di Torino, Corso Svizzera, Italy.
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Pollono
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Biglino
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D000882:Haplorhini; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009183:Mycotoxins / Q000494:pharmacology*; D012756:Sheep; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009183:Mycotoxins; D000242:Cyclic AMP