[Effects of fructose on left ventricular function during hypoxia].
The effects of fructose on cardiac function and myocardial metabolism during hypoxia were compared with those of saline infusion in the anesthetized mongrel dogs. Hypoxia was induced with inhalation of low fraction of oxygen (PaO2 = 15 mmHg) for two hours. Fructose (N = 7) was infused intravenously at a rate of 1 g.kg-1.h-1 and saline (N = 7) was infused at 5 ml.kg-1.h-1, in the same volume as fructose infusion. Both infusions were started at the induction of hypoxia. In the fructose group, two of seven dogs died within 90 min, and other dogs within 120 min. After 120 min, only one dog survived. In saline group, three of seven dogs died within 60 min, another within 90 min, and three others died within 120 min. In both groups, the dogs with cardiac arrest at an early period tended to show low levels of blood glucose and high levels of lactic acid. Blood glucose levels were similar in both groups, but % increase of blood glucose from control and myocardial glucose uptake tended to be higher in fructose group than in saline group. Blood lactic acid (LA) levels increased significantly in both groups, but, in fructose group, LA levels were higher, and arterial pH decreased more than those in saline group. In fructose group maximum rate of rise of left ventricular pressure (LV dp/dt max) correlated with intramyocardial pH (r = 0.834, P < 0.01), but not with LA levels nor with difference of blood lactic acid from control (d-LA).(ABSTRACT TRUNCATED AT 250 WORDS)
Mori
K
K
Department of Anesthesiology, Tokushima University School of Medicine.
Kohyama
A
A
D000140:Acidosis, Lactic / Q000209:etiology; D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005632:Fructose / Q000009:adverse effects / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009206:Myocardium / Q000378:metabolism; D016277:Ventricular Function, Left / Q000187:drug effects*
D001786:Blood Glucose; D007773:Lactates; D005632:Fructose; D019344:Lactic Acid