Isolation of a polysaccharide with antiviral effect from Ulva lactuca.
A polysaccharide from the green marine algae Ulva lactuca has been isolated. The substance has been investigated after acid hydrolysis by thin-layer and gas chromatography. The following carbohydrate components have been found: arabinose-xylose-rhamnose-galactose-mannose-glucose in ratio 1:1:9:5:2.5:16 respectively. One unidentified sugar has been demonstrated too. The polysaccharide has been studied for antiviral activity in vitro against a number of human and avian influenza viruses. A considerable inhibition of the viral reproduction was found. The effect was dose-dependent, strain-specific and selective.
Ivanova
V
V
Institute of Microbiology, Bulgarian Academy of Science, Sofia.
Rouseva
R
R
Kolarova
M
M
Serkedjieva
J
J
Rachev
R
R
Manolova
N
N
D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001089:Arabinose / Q000032:analysis; D000460:Chlorophyta / Q000737:chemistry*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005690:Galactose / Q000032:analysis; D005947:Glucose / Q000032:analysis; D008358:Mannose / Q000032:analysis; D009975:Orthomyxoviridae / Q000187:drug effects; D011134:Polysaccharides / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D012210:Rhamnose / Q000032:analysis; D013055:Spectrophotometry, Infrared; D014994:Xylose / Q000032:analysis
D000998:Antiviral Agents; D011134:Polysaccharides; D014994:Xylose; D001089:Arabinose; D005947:Glucose; D008358:Mannose; D012210:Rhamnose; D005690:Galactose