title: [Massive endocardial thrombosis in a patient with a peritoneo-jugular shunt for refractory ascites: the therapeutic success of tissue plasminogen activator and defibrotide].
abstract: The authors report a case of a patient with a refractory ascites due to extrahepatic portal thrombosis in course of idiopathic thrombocythemia. A peritoneovenous shunt was applied and as a late complication a massive thrombosis of the intracardiac portion of the duct developed. Thrombolysis was obtained with tissue plasminogen activator at doses usually administered for acute myocardial infarction. Prophylaxis of recurrence was pursued with pictomide and defibrotide.
authors.affiliation: Divisione di Medicina III, Università, USL 16, Modena.
authors.forename: C
authors.initials: C
authors.lastname: Sacchetti
authors.forename: S
authors.initials: S
authors.lastname: Pederzoli
authors.forename: E
authors.initials: E
authors.lastname: Tamborrino
authors.forename: M
authors.initials: M
authors.lastname: Grandi
mesh_terms: D000328:Adult; D001201:Ascites / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D010536:Peritoneovenous Shunt / Q000009:adverse effects; D010795:Phthalic Acids / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011089:Polydeoxyribonucleotides / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010795:Phthalic Acids; D010975:Platelet Aggregation Inhibitors; D011089:Polydeoxyribonucleotides; D011994:Recombinant Proteins; C036901:defibrotide; C011581:picotamide; D010959:Tissue Plasminogen Activator
vernacular_title: Trombosi massiva endocardica in paziente portatrice di dotto peritoneo-giugulare per ascite refrattaria: successo terapeutico dell'attivatore tessutale del plasminogeno e del defibrotide.