title: [Rhinorrhea and otorrhea: rare complications of the medical treatment in invasive prolactinomas].
abstract: Cerebrospinal fluid rhinorrhea and otorrhea are rare complications of conservative and medical management of invasive macroprolactinomas. The slow shrinkage of the tumor during therapy is responsible for delayed rhinorrhea and otorrhea which carry the risk of meningitis. The operative procedure for closure of the fistulae is needed. We report the occurrence of CSF rhinorrhea in two patients with macroprolactinoma who were treated by bromocriptine. In one patient the fistulae is surgically treated and the treatment by bromocriptine is maintained. In the other patient the rhinorrhea is associated with otorrhea and the operation is not required because of the massive destruction of skull base. The CSF rhinorrhea and otorrhea stopped after diminution of bromocriptine doses.
authors.affiliation: Clinique Médicale et Endocrinologique, CHU de Nancy-Brabois, Vandoeuvre les Nancy.
authors.forename: V
authors.initials: V
authors.lastname: Pascal-Vigneron
authors.forename: G
authors.initials: G
authors.lastname: Weryha
authors.forename: M
authors.initials: M
authors.lastname: Braun
authors.forename: J
authors.initials: J
authors.lastname: Morel-Jean
authors.forename: S
authors.initials: S
authors.lastname: Bisset
authors.forename: J
authors.initials: J
authors.lastname: Leclère
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D002558:Cerebrospinal Fluid Otorrhea / Q000139:chemically induced*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015175:Prolactinoma / Q000188:drug therapy* / Q000473:pathology
chemical_list: D001971:Bromocriptine
vernacular_title: La rhinorrhée et l'otorrhée: des complications rares du traitement médical des prolactinomes invasifs.