title: A numerical analysis of a focused ultrasound technique to measure perfusion.
abstract: A noninvasive technique to measure perfusion using a focused ultrasound heating source and a thermistor placed on the surface of a tissue is proposed. The method is numerically examined in a model of the canine kidney. The perfusion measurement is shown to depend on several transducer and tissue thermal properties. A two level fractional factorial design simulation is used to map out a parameter value combination that maximizes the sensitivity of the measurement. A technique to numerically assess the uncertainty in the measurement due to uncertainties in the tissue and transducer parameter values is also described. The effects of the medulla and a subcapsular surface layer in the kidney are examined. It is determined that the maximum error in the measured perfusion rate due to all the factors considered is 17 percent for a kidney with a nominal perfusion rate of 300 mL/100g-min and a surface layer of 0.04 cm thickness.
authors.affiliation: Department of Electronics and Instrumentation, University of Arkansas at Little Rock 72202.
authors.forename: G T
authors.initials: GT
authors.lastname: Anderson
authors.forename: X
authors.initials: X
authors.lastname: Ye
mesh_terms: D000818:Animals; D015982:Bias; D001831:Body Temperature; D004285:Dogs; D005069:Evaluation Studies as Topic; D005163:Factor Analysis, Statistical; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013814:Thermal Conductivity; D014159:Transducers; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography