The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes.
The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT effects in a variety of in vitro and in vivo assays. Here, we show that, in contrast to its antagonistic action on NT-induced hypomotility in the rat, SR 48692 failed to antagonize NT-induced hypothermia and analgesia in the mouse and rat. We suggest that these effects might be mediated through a subtype of SR 48692-insensitive NT receptor.
Dubuc
I
I
Unité de Neuropsychopharmacologie Expérimentale, UA 1170 CNRS, Faculté de Médecine-Pharmacie de Rouen, St-Etienne du Rouvray, France.
Costentin
J
J
Terranova
J P
JP
Barnouin
M C
MC
Soubrié
P
P
Le Fur
G
G
Rostène
W
W
Kitabgi
P
P
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009496:Neurotensin / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D010147:Pain Measurement / Q000187:drug effects; D011720:Pyrazoles; D011804:Quinolines; D051381:Rats; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors* / Q000145:classification*
D000700:Analgesics; D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C079087:SR 48692; D009496:Neurotensin