title: Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
abstract: A new cancer cell line (Lu-165) producing a large amount of anti-diuretic hormone (ADH, 2.8 micrograms/g protein) was established from a 50-year-old small cell lung cancer patient presenting with a syndrome of inappropriate anti-diuretic hormone secretion. These cells grew well in serum-supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH-producing cancer.
authors.affiliation: Pathology Division, National Cancer Center Hospital, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Terasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Y
authors.initials: Y
authors.lastname: Shimosato
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Ichinose
authors.forename: T
authors.initials: T
authors.lastname: Nagatsu
authors.forename: K
authors.initials: K
authors.lastname: Kato
mesh_terms: D000818:Animals; D018288:Carcinoma, Small Cell / Q000378:metabolism* / Q000648:ultrastructure; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured; D014667:Vasopressins / Q000096:biosynthesis*
chemical_list: D014667:Vasopressins