[Distribution of platinum in the female genital tract after intraarterial carboplatin infusion during the operation of uterine cervical cancer].
We investigated the platinum concentration in the female genital tract, the regional lymph nodes and serum after intraarterial carboplatin 150mg infusion during the operation of uterine cervical cancer. The following results were obtained. 1. The mean platinum concentration in the region of cervical cancer was highest (1.77 micrograms/g wet tissue of the female genital tract). However the other genital tract including the endometrium, ovary and fallopian tube showed the same platinum concentration. 2. The level of the serum total platinum concentration became maximum at 30 min and gradually decreased thereafter. From these results, intraarterial CBDCA infusion seemed to show the therapeutic effect against the primary region of uterine cancer and the other genital tract.
Nagai
N
N
Dept. of Obstetrics and Gynecology, Hiroshima University School of Medicine.
Murakami
T
T
Ohama
K
K
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D016190:Carboplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007430:Intraoperative Care; D008198:Lymph Nodes / Q000378:metabolism; D010984:Platinum / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery
D010984:Platinum; D016190:Carboplatin