[Cytological features and prognosis of megakaryoblastic leukemia].
Nine patients with acute leukemia showing 10% or more positive blast cells with platelet peroxidase (PPO) or CD41b were diagnosed as megakaryoblastic leukemia. Three patients transformed from myelodysplastic syndromes or myeloproliferative disorders. The PPO positivity ranged from 7 to 55% (median 45%), and that for CD41b was 1.6 to 67.0% (median 16.4%). Because electron microscopic myeloperoxidase or glycophorin A were also positive in some patients, and also because CD41b positivity was often discordantly lower than PPO positivity, a possibility of mixed leukemia demonstrating myeloid or erythroid differentiation was suggested in 6 of these cases. As for the treatment results, all 3 pediatric cases who received combination chemotherapy achieved complete remission (CR). Among 6 adult cases CR was obtained in only one patient to whom low-dose cytosine arabinoside was administered. The remaining adult patients who received combination chemotherapy died relatively early.
Miyoshi
Y
Y
Department of Medicine, Kinugasa Hospital.
Takahashi
N
N
Tada
J
J
Higuchi
T
T
Maeda
T
T
Shimizu
T
T
Harada
H
H
Okada
S
S
Mori
H
H
Niikura
H
H
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008854:Microscopy, Electron; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D009195:Peroxidase / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage; D011379:Prognosis; D013920:Thrombocythemia, Essential / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
D000911:Antibodies, Monoclonal; D009607:Nitrosourea Compounds; D003561:Cytarabine; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D009195:Peroxidase; D008727:Methotrexate