title: Synthesis and muscle relaxant activity of cyclic baclofen analogues.
abstract: Some new cyclic analogues of baclofen have been prepared and characterized, starting from 4-(4-chlorophenyl)-pyrrolidone. When tested in comparison with the parent compound, they exhibited only a moderate muscle relaxant activity.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pifferi
authors.forename: R
authors.initials: R
authors.lastname: Nizzola
authors.forename: A
authors.initials: A
authors.lastname: Cristoni
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D013569:Synapses / Q000187:drug effects / Q000502:physiology
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen