title: GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
abstract: We describe experiments which show that: 1) two previously identified members of the GATA family of transcription factors (both of which were originally called GATA-4) correspond to chicken cDNAs for two distinct factors (which we now refer to as cGATA-4 and cGATA-5); 2) another new member of this family corresponds to a third factor designated cGATA-6; 3) each of these mRNAs displays a differential expression pattern. The cGATA-5 gene is initially transcribed in the cardiac crescent prior to formation of the primordial heart tube. Following formation of the primitive heart, cGATA-5 transcripts are evident in both endocardium and myocardium as well as in other lateral plate derivatives. The cGATA-5 gene is also transcribed in the primitive embryonic gut and in late stage embryos is sequentially up-regulated in distinct segments of gastrointestinal epithelia as they undergo terminal differentiation. These studies thus provide novel insights into tissue-specific regulation by GATA-5, as well as into possibly overlapping regulatory functions for these three family members.
authors.affiliation: Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
authors.forename: A C
authors.initials: AC
authors.lastname: Laverriere
authors.forename: C
authors.initials: C
authors.lastname: MacNeill
authors.forename: C
authors.initials: C
authors.lastname: Mueller
authors.forename: R E
authors.initials: RE
authors.lastname: Poelmann
authors.forename: J B
authors.initials: JB
authors.lastname: Burch
authors.forename: T
authors.initials: T
authors.lastname: Evans
mesh_terms: D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002642:Chick Embryo; D002645:Chickens; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D004064:Digestive System / Q000196:embryology / Q000378:metabolism*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D050991:GATA4 Transcription Factor; D050992:GATA5 Transcription Factor; D050993:GATA6 Transcription Factor; D006321:Heart / Q000196:embryology; D008648:Mesoderm / Q000378:metabolism; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D050991:GATA4 Transcription Factor; D050992:GATA5 Transcription Factor; D050993:GATA6 Transcription Factor; D014157:Transcription Factors