Is the elimination of endotoxin and cytokines with continuous lavage an alternative procedure in necrotizing enterocolitis?
Ascites fluid was obtained intraoperatively in 12 consecutively treated neonates (6M, 6F, mean weight 940 g, mean gestational age 27th week, lethality 3/12) suffering from necrotizing enterocolitis (NEC). The concentrations of endotoxin and cytokines (IL-1, IL-6, TNF) were determined. Endotoxin and interleukins were excessively elevated in all patients, TNF only in those who survived. Postoperative treatment included the use of a continuous abdominal lavage system. This therapeutical procedure allows the elimination of endotoxin and cytokines out of the abdominal cavity in order to reduce their adverse biological effect.
Birk
D
D
Department of General Surgery, University Ulm, Germany.
Berger
D
D
Limmer
J
J
Beger
H G
HG
D001201:Ascites / Q000276:immunology* / Q000382:microbiology; D003131:Combined Modality Therapy; D016207:Cytokines / Q000032:analysis* / Q000502:physiology; D004731:Endotoxins / Q000032:analysis* / Q000502:physiology; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology* / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007375:Interleukin-1 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D010533:Peritoneal Lavage; D015996:Survival Rate; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D004731:Endotoxins; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha