title: Some 'difficult sequences' made easy. A study of interchain association in solid-phase peptide synthesis.
abstract: Case studies of the solid-phase synthesis of some 'difficult sequences' using continuous-flow Fmoc-polyamide techniques are presented. Solvent change and peptide side chain and backbone modification procedures recently found to reduce association effects are applied, and the results compared to syntheses under standard conditions.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Hyde
authors.forename: T
authors.initials: T
authors.lastname: Johnson
authors.forename: D
authors.initials: D
authors.lastname: Owen
authors.forename: M
authors.initials: M
authors.lastname: Quibell
authors.forename: R C
authors.initials: RC
authors.lastname: Sheppard
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids; D005449:Fluorenes; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012997:Solvents
chemical_list: D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; D012997:Solvents