Cardiovascular protection by oestrogen--a calcium antagonist effect?
During their premenopausal years, women have a lower risk than men of getting cardiovascular disease. This protection continues after the menopause if women receive oestrogen replacement. Based on new experimental evidence we propose that some of the cardiovascular benefits of oestrogen replacement therapy may be due to a long-term calcium antagonist effect of oestrogen.
Collins
P
P
Department of Cardiac Medicine, National Heart and Lung Institute, London, UK.
Rosano
G M
GM
Jiang
C
C
Lindsay
D
D
Sarrel
P M
PM
Poole-Wilson
P A
PA
D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D002118:Calcium / Q000037:antagonists & inhibitors*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects*; D003327:Coronary Disease / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans
D002121:Calcium Channel Blockers; D004967:Estrogens; D002118:Calcium