[Studies on the anticonvulsive activity of pyrazolidinones].
The anticonvulsive activity of three kinds of pyrazolidinones: 5-benzyl-substituted-3-pyrazolidinones; 5-benzyl-1-alkyl substituted and 1-alkyl substituted-3-pyrazolidinones were studied. Fourteen substitutes of these three kinds of pyrazolidinones were found to be potent anticonvulsants. In doses less than TD50, they were found to be able to protect mice and rats from seizures produced by maximal electroshock seizure (MES), such action appeared rapidly and lasted for a short period. II-f was shown to be the most potent anti-MES agent among these three kinds of pyrazolidinones. It also showed therapeutic effect in treating experimental epilepsy produced by intrahippocampal injection of zinc sulfate in rabbits and audiogenic seizures in rats. The third kind of pyrazolidinones also showed anti-metrazol induced seizures in mice.
Liu
J F
JF
Department of Pharmacology, Beijing Medical University.
Pei
Y Q
YQ
Wang
Z D
ZD
Xu
J G
JG
Lei
X P
XP
Ling
Y Z
YZ
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use* / Q000633:toxicity; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000627:therapeutic use* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D013431:Sulfates; D017967:Zinc Compounds; D019287:Zinc Sulfate
D000927:Anticonvulsants; D011720:Pyrazoles; D013431:Sulfates; D017967:Zinc Compounds; D019287:Zinc Sulfate