Immunohistochemical study of neu protein overexpression in clinging in situ duct carcinoma of the breast.
The expression of neu protein in 26 cases of clinging carcinoma (CC) of the breast was investigated. A distinction is made between two types of CC: one with pleomorphic nuclei (PN) and the other with monomorphic nuclei (MN). The PN type of CC overexpresses the neu protein in almost all cases (85.7%), its cells generally exhibit abundant cytoplasm and intraluminal necrosis is frequently observed. The MN type of CC does not overexpress the neu protein, exhibits bland cytological features and shows no necrosis. It is suggested that CC with PN is related to comedo-type carcinoma, while CC with MN is the forerunner of cribriform carcinoma in situ.
De Potter
C R
CR
N. Goormaghtigh Instituut voor Pathologische Anatomie, Universitair Ziekenhuis Gent, Belgium.
Foschini
M P
MP
Schelfhout
A M
AM
Schroeter
C A
CA
Eusebi
V
V
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry* / Q000145:classification; D002278:Carcinoma in Situ / Q000737:chemistry* / Q000145:classification; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry* / Q000145:classification; D005260:Female; D006801:Humans; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D018719:Erb-b2 Receptor Tyrosine Kinases
D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases