Structural analysis of c-myc in human sporadic colorectal carcinomas.
Analysis of the DNA extracted from the colonic mucosa of 13 patients operated for colorectal carcinoma revealed c-myc rearrangements in three of them. In all cases, the alterations were found both in the histologically normal and in the tumoral mucosa. In one case, a different pattern of rearrangements characterized the two tissues. In all three individuals, the c-myc sequences appeared to be amplified. We suggest that c-myc rearrangements in the histologically normal colonic mucosa of colorectal carcinoma patients could represent a predisposition factor for the development of additional neoplasms.
Albanese
I
I
Dipartimento di Biologia Cellulare e dello Sviluppo, University of Palermo, Italy.
Alberti
M
M
Bazan
V
V
Russo
A
A
Baiamonte
S
S
Migliavacca
M
M
Bazan
P
P
La Farina
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies