[Anaphylactic shock after repeated injection of 99mTc-labeled CEA antibody].
In a 64-year old patient with a recurrent rectal carcinoma, immunoscintigraphies with 99mTc-labelled monoclonal antibody against CEA (BW 431/26) were performed in an interval of 14 months. A few minutes after the second injection the patient reacted with anaphylactic shock which could be controlled by epinephrine and cortisone. As far as we know, there is no report in the literature on an anaphylactic reaction to this antibody. An investigation for human anti-mouse antibodies before the second injection was negative with one method and positive with another method.
Rettenbacher
L
L
Institut für Nuklearmedizin und Endokrinologie Landeskrankenanstalten Salzburg, Osterreich.
Galvan
G
G
D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D003348:Cortisone / Q000627:therapeutic use; D004837:Epinephrine / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D051379:Mice / Q000276:immunology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011877:Radionuclide Imaging; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging*; D013667:Technetium
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D013667:Technetium; D003348:Cortisone; D004837:Epinephrine
Anaphylaktischer Schock nach wiederholter Injektion von 99mTc-markiertem CEA-Antikörper.