title: Hypercalcemia, monoclonal protein, and osteolytic bone lesions in chronic lymphocytic leukemia.
abstract: We describe a patient with a long history of typical chronic lymphocytic leukemia (CLL) who developed hypercalcemia, osteolytic bone lesions, and a monoclonal protein, all features of a secretory plasma cell disorder. These features in CLL have been reported in only four previous cases. The hypercalcemia in our patient is felt to result from an increase in the osteoclastic process.
authors.affiliation: University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Van de Casteele
authors.forename: G E
authors.initials: GE
authors.lastname: Verhoef
authors.forename: H
authors.initials: H
authors.lastname: Demuynck
authors.forename: P
authors.initials: P
authors.lastname: Zacheé
authors.forename: M A
authors.initials: MA
authors.lastname: Boogaerts
mesh_terms: D000328:Adult; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D007075:Immunoglobulin M / Q000378:metabolism*; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000378:metabolism*; D008297:Male; D010014:Osteolysis / Q000150:complications*
chemical_list: D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains