Genetic control of delayed-type hypersensitivity to chromium chloride.
Genetic control of delayed-type hypersensitivity (DTH) to chromium chloride antigen was studied in various strains of mice. Mice with I-Ab,d,f,k,r were high magnitude responders, whereas those with I-Aq,s were low magnitude responders. Studies with recombinant strains indicate that chromium chloride DTH may be influenced by the I-A region of H-2. DTH to chromium chloride is an antigen-specific response. We further revealed that response to chromium chloride does not cross-react with response to cobalt or nickel chloride. Also, transfer experiments using lymph node cells suggest that these responses are mediated by CD4+8-, Ia-T cells.
Ishii
N
N
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Takahashi
K
K
Kawaguchi
H
H
Nakajima
H
H
Tanaka
S
S
Aoki
I
I
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D002712:Chlorides; D002857:Chromium / Q000276:immunology*; D017608:Chromium Compounds; D002874:Chromosome Mapping; D006968:Hypersensitivity, Delayed / Q000235:genetics* / Q000276:immunology; D007116:Immunization, Passive; D016130:Immunophenotyping; D051379:Mice; D008815:Mice, Inbred Strains; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016827:CD8 Antigens; D002712:Chlorides; D017608:Chromium Compounds; D002857:Chromium; C017133:chromous chloride