Deconvolution method for assessing the absorption of a drug with reversible metabolic pathways.
A method has been established to determine the input rate for a drug with reversible metabolic processes. This method is based on linear system properties without imposing a compartment model for describing the disposition of the drug and the metabolite and their interconnections. The solution is a deconvolution method in N-dimensional space. A general solution has been obtained for calculating the parameters needed to describe the input function. The specific solution for a staircase input function (point-area deconvolution) is explicitly derived. Using a staircase input function is not a robust method and can give negative input values when applied to simulated data sets with a large amount of variability. This suggests the need for more robust functional forms to describe the input function.
Hwang
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Alza Corporation, Palo Alto, CA 94303.
Knowles
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D000042:Absorption; D000818:Animals; D008432:Mathematical Computing; D008722:Methods; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D051381:Rats; D013454:Sulfoxides / Q000097:blood; D013467:Sulindac / Q000031:analogs & derivatives / Q000097:blood
D004364:Pharmaceutical Preparations; D013454:Sulfoxides; D013467:Sulindac; C025462:sulindac sulfide