title: Beta 2-agonists and running economy in prepubertal boys.
abstract: Asthmatic athletes (adults and junior) have competed successfully at the highest level for many years assisted by pre-event medication with beta 2-agonists. To examine the impact of beta 2-agonists upon submaximal running economy (oxygen consumption at a given submaximal work load), we studied 10 nonasthmatic boys (age, 10.4 +/- 0.48 years, mean +/- SD). They each completed submaximal (speeds, 7.2, 8.0 and 8.8 km/hr) and peak treadmill running protocols preceded by treatment with beta 2-agonist (terbutaline, 500 micrograms via nebuhaler) or placebo in a randomized, crossover single-blind study. No significant differences were found between running economy and heart rate during the submaximal exercise tests or between peak oxygen consumption (VO2), peak respiratory exchange ratio, peak heart rate (HR), or total running time during the peak VO2 test. Pretreatment with terbutaline did produce small but nonsignificant increases in aerobic fractional utilization (percent peak VO2 on drug: 65.9%, 72.6%, and 76.7% vs. placebo: 65.1%, 70%, and 75.5%), at the three submaximal work loads. Respiratory exchange ratio (RER) values were elevated throughout the submaximal tests (on drug: 0.94, 0.93, and 0.94 vs placebo: 0.91, 0.92, and 0.91, P < 0.05). No significant differences were found between drug and placebo for minute ventilation (VE) and ventilatory equivalent for oxygen (VE/VO2), at both submaximal and peak exercise intensities.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Child Health, University of Glasgow, Royal Hospital for Sick Children, Scotland, UK.
authors.forename: V B
authors.initials: VB
authors.lastname: Unnithan
authors.forename: K J
authors.initials: KJ
authors.lastname: Thomson
authors.forename: T C
authors.initials: TC
authors.lastname: Aitchison
authors.forename: J Y
authors.initials: JY
authors.lastname: Paton
mesh_terms: D000280:Administration, Inhalation; D000704:Analysis of Variance; D001249:Asthma; D002648:Child; D005080:Exercise Test; D005541:Forced Expiratory Volume / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D010101:Oxygen Consumption / Q000187:drug effects*; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D012420:Running / Q000502:physiology; D016037:Single-Blind Method; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D016526:Workload
chemical_list: D013726:Terbutaline