Severe rhabdomyolysis after doxylamine overdose.
Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines. The easy availability of these substances increases the potential not only for intentional overdose by adults but also for inadvertent ingestion by children. Prompt intervention and careful assessment of renal function, urinary output, and serum creatine kinase levels may represent the difference between an uncomplicated course and acute renal failure.
Soto
L F
LF
Northeastern Ohio Universities College of Medicine.
Miller
C H
CH
Ognibere
A J
AJ
D000328:Adult; D001639:Bicarbonates / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D004319:Doxylamine / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D062787:Drug Overdose / Q000097:blood / Q000150:complications; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D006634:Histamine H1 Antagonists / Q000097:blood / Q000506:poisoning*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D012206:Rhabdomyolysis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012563:Schizophrenia, Paranoid / Q000150:complications; D012964:Sodium / Q000627:therapeutic use; D017693:Sodium Bicarbonate; D013406:Suicide, Attempted
D001639:Bicarbonates; D006634:Histamine H1 Antagonists; D017693:Sodium Bicarbonate; D004319:Doxylamine; D012964:Sodium; D003402:Creatine Kinase; C035385:doxylamine succinate