[Changes of plasma motilin concentration in pregnancy and early postpartum period].
Plasma motilin concentration were determined by radioimmunoaction from 180 women during pregnancy and early postpartum period as compared with 20 healthy non-pregnant women. The results showed that mean plasma motilin concentration (384.40 +/- 110.30 ng/L) was higher in the first trimester of pregnancy than that of healthy non-pregnant women (366.12 +/- 96.23 ng/L), however, this difference did not reach statistical significance (P > 0.05). The mean plasma motilin concentration (323.90 +/- 125.10 ng/L) was lower in the second trimester of pregnancy than in the first trimester of pregnancy (P < 0.05), while the mean plasma motilin concentration in the third trimester of pregnancy (121.04 +/- 27.00 ng/L) was significantly lower than in second (P < 0.01) and the mean plasma motilin concentration in 3-5 d after delivery (443.05 +/- 140.79 ng/L) reached an even higher value (P < 0.01). Our results suggests that pregnancy appears to have a profound inhibitory effect on plasma motilin and this may in part be responsible for the gastrointestinal hypomotility during pregnancy.
Qiu
X H
XH
Department of Obstetrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xian.
Yang
M G
MG
Peng
J J
JJ
Tong
P
P
Huang
Y X
YX
Xu
C F
CF
Wang
Q L
QL
Zhang
M N
MN
D000328:Adult; D005260:Female; D006801:Humans; D009037:Motilin / Q000097:blood*; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
D009037:Motilin