Blockade of thalamic GABAB receptors decreases EEG synchronization.
The gamma-aminobutyric acid (GABA)B receptor antagonists 2-OH-saclofen and CGP 35348 were injected in the thalamus of freely moving cats via a microdialysis probe while recording the sleep-walking cycle. The results obtained with the two antagonists were similar: wakefulness and the total sleep time were not affected by the blockade of GABAB receptors, but deep slow wave sleep and the mean power of slow waves (< 10 Hz) were decreased, while light slow wave sleep was increased. These data suggest an involvement of thalamic GABAB receptors in the regulation of EEG slow waves.
Juhász
G
G
Department of Comparative Physiology, Eötvös Lóránd University, Budapest, Hungary.
Emri
Z
Z
Kékesi
K A
KA
Salfay
O
O
Crunelli
V
V
D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives / Q000494:pharmacology; D002415:Cats; D003344:Cortical Synchronization / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D004585:Electrooculography / Q000187:drug effects; D058788:GABA-B Receptor Antagonists; D017551:Microdialysis; D009943:Organophosphorus Compounds / Q000494:pharmacology; D012890:Sleep / Q000502:physiology; D013788:Thalamus / Q000187:drug effects* / Q000378:metabolism; D014851:Wakefulness / Q000187:drug effects
D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348; D001418:Baclofen; C057491:2-hydroxysaclofen