Immunocytochemical characterization of intrarenal adrenal tissue.
Heterotopic adrenal tissue has been reported in multiple sites, but its functionality has seldom been assessed. In this case, immunocytochemistry was used to characterize adrenocortical tissue present in the subcapsular region of a nephrectomy specimen and to determine its potential for steroidogenesis. Immunodetectable cytochrome P450scc was detectable in the adrenal gland, but not in the renal tissue, clarifying the demarcation between the two tissue types. The high level of this key enzyme in steroid synthesis in the adrenocortical cells suggested that they were capable of producing steroids.
Chin
L
L
Department of Cell Biology, New York University School of Medicine, New York.
Brody
R I
RI
Morales
P
P
Black
V H
VH
D000302:Adrenal Cortex / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D002828:Choristoma / Q000473:pathology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy
D003577:Cytochrome P-450 Enzyme System