Oral retention of glucose at pharmacologically reduced salivary flow in man.
The aim was to study the influence of mouthrinses with glucose, at concentrations ranging from 1 to 50%, on oral retention at two different locations in the oral cavity. Salivary secretion was reduced in 10 subjects by injection of methylscopolamine nitrate submucosally. The volunteers were randomly assigned to rinse with 10 ml of either 1%, 10%, or 50% glucose solution for 30 s, after which measurements of glucose concentration and parotid salivary secretion rate were performed during a 10-min period. The results showed higher salivary glucose levels vestibularly than sublingually. The difference in glucose retention between the two locations increased when the salivary flow rate recovered. The relationship between secretion rate and area under the curve for glucose measured sublingually, but not in the vestibule, was bilinear.
Hase
J C
JC
Department of Cardiology, University of Lund, Centre for Oral Health Sciences, Malmö, Sweden.
Birkhed
D
D
Lagerlöf
F
F
Thornqvist
E
E
D000328:Adult; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism*; D009067:Mouthwashes; D019832:N-Methylscopolamine; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology; D010306:Parotid Gland / Q000187:drug effects* / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D012602:Scopolamine Derivatives / Q000008:administration & dosage / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects
D009067:Mouthwashes; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; D005947:Glucose; D019832:N-Methylscopolamine