Effect of Brassica nigra on benzo[a]pyrene mutagenicity.
Male rats were given diets containing Brassica nigra (mustard seed) powder at 0, 1, 5 or 10% for 1 month and then exposed to benzo[a]pyrene (B[a]P. 1 mg by ip injection). The antimutagenic effect due to mustard was assessed by testing the urine of rats fed diets with and without mustard. There was a significant (P < 0.001) reduction in reversion frequency of the TA98 and TA100 strains of Salmonella typhimurium in mustard-fed groups. This protective effect was seen with all three doses of mustard. The study demonstrated that mustard (Brassica nigra) can be a potent antagonist of the adverse biological effects of the ultimate metabolites of B[a]P, a ubiquitous environmental genotoxicant.
Polasa
K
K
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad.
Kumar
P U
PU
Krishnaswamy
K
K
D000818:Animals; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors / Q000633:toxicity*; D001937:Brassica; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014556:Urine / Q000737:chemistry
D009153:Mutagens; D001564:Benzo(a)pyrene