Genetic epidemiologic study of hearing loss in an adult population.
Previous population studies of hearing loss have been limited to children with moderate to profound impairment, and have reported that heritability accounts for at least 50% of congenital or early-onset cases. The present study was designed to assess genetic factors associated with late-onset hearing impairment in an adult population. A brief family history and audiologic questionnaire was sent to approximately 11,200 members of the consumer organization, Self Help for the Hard of Hearing, Inc., and 4,039 questionnaires were returned. All respondents reported having at least one previous audiologic exam. Reported data were verified against audiograms when available. Regardless of the reported causes, 49% of early-onset cases (< or = 20 years of age) had one or two parent(s) with some form of hearing loss compared with 62% in later-onset cases. As expected, mean age at onset was substantially younger for cases with positive family histories than cases with negative family histories. Results from nuclear segregation analysis showed that fully recessive and dominant models failed to explain the early- or late-onset hearing loss data. In this nationwide survey, the large proportion of cases with positive family histories clearly indicates the importance of genetic factors in adult-onset forms of hearing loss. Comparison with younger-onset cases will permit further delineation of differences in inheritance patterns. This study should identify more homogeneous groups of adult-onset families for further genetic study, and provide empiric information for use in genetic counselling.
Sill
A M
AM
Division of Human Genetics, University of Maryland at Baltimore 21201.
Stick
M J
MJ
Prenger
V L
VL
Phillips
S L
SL
Boughman
J A
JA
Arnos
K S
KS
D000328:Adult; D017668:Age of Onset; D001299:Audiometry; D003710:Demography; D005260:Female; D006311:Hearing Disorders / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male