[Sympathetic reinnervation following heart transplantation--a double-tracer study with 123I-MIBG and 201Tl].
Sympathetic reinnervation was evaluated in 15 patients 2-69 months after heart transplantation using a double-tracer technique with 123I-MIBG and 201Tl. Since MIBG is accumulated in the same manner as norepinephrine it may serve as a tracer of the integrity and function of the sympathetic nervous system. 201Tl was used for landmarking. Planar anterior imaging was performed 15 min and 4 h after i.v. injection of 220 MBq 123I-MIBG and 37 MBq 201Tl. Image quantitation was based on the ratio of myocardial to mediastinal MIBG-uptake. Cardiac regions of interest were defined according to the 201Tl uptake. There was no evidence of sympathetic reinnervation in 8 patients 2-34 months after transplantation. Increased MIBG-uptake could be observed in the anterior basal region in 6 long-term cardiac transplants (37-69 months). One patient with a 59-month-old transplanted heart did not reinnervate. Increased MIBG-uptake in the anterior basal region indicating partial sympathetic reinnervation could be shown in 40% of the investigated patients with an average organ age of 51 months.
Gürtner
C
C
Abteilung Nuklearmedizin, Universitätsklinikum Frankfurt/Main, FRG.
Klepzig
H
H
Lelbach
S
S
Krause
B J
BJ
Hartmann
A
A
Maul
F D
FD
Kranert
W T
WT
Hör
G
G
D019797:3-Iodobenzylguanidine; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013564:Sympathetic Nervous System / Q000502:physiology*; D013793:Thallium / Q000493:pharmacokinetics; D013997:Time Factors
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D013793:Thallium
Sympathische Reinnervation nach Herztransplantation--Doppelnuklidstudie mit 123J-MIBG und 201Tl.