title: Ammonium urate nephrolithiasis in a variant of Bartter's syndrome with intact renal tubular function.
abstract: In two patients with Bartter's syndrome proximal tubular function and distal chloride reabsorption were intact on admission; however, chloride reabsorption and distal tubular acidifying capacity decreased in one patient over a period of 10 years. Renal prostaglandin E excretion and urinary and plasma uric acid were in the normal range, but urinary ammonium was significantly elevated during controlled diet. One patient developed ammonium urate nephrolithiasis. In both patients renal biopsy demonstrated lymphocytic infiltration of the interstitial tissue and hypercellularity of the macula densa. Indomethacin treatment improved serum potassium concentration and decreased plasma renin activity, plasma aldosterone concentration, and urinary prostaglandin E but had to be discontinued because of side effects. It is likely that our patients represent a variant form of the syndrome originally described by Bartter.
authors.affiliation: Second Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Yasuda
authors.forename: R
authors.initials: R
authors.lastname: Zierer
authors.forename: A
authors.initials: A
authors.lastname: Maio
authors.forename: H
authors.initials: H
authors.lastname: Shioniri
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000328:Adult; D001477:Bartter Syndrome / Q000150:complications* / Q000503:physiopathology; D002712:Chlorides / Q000097:blood; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D007669:Kidney Calculi / Q000737:chemistry* / Q000209:etiology / Q000503:physiopathology; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000503:physiopathology*; D008138:Loop of Henle / Q000503:physiopathology; D011458:Prostaglandins E / Q000032:analysis; D012083:Renin / Q000097:blood; D013577:Syndrome; D014513:Ureter / Q000002:abnormalities; D014527:Uric Acid / Q000032:analysis*
chemical_list: D002712:Chlorides; D011458:Prostaglandins E; D014527:Uric Acid; D012083:Renin