Uterus estrogen receptors' binding capacity is reduced in rat if exposed by benzpyrene neonatally.
During the critical period of receptor maturation within the first 5 days after birth female rats were treated with benzpyrene three times and their uterus estrogen receptor characteristic were examined in adulthood. Estrogen receptor density decreased significantly. There was no alteration in receptor affinity. Present experiment draws attention to the disadvantageous effect of aromatic hydrocarbons coming from the polluted air on steroid receptor development.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
D000818:Animals; D000831:Animals, Newborn; D001580:Benzopyrenes / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D001580:Benzopyrenes; D011960:Receptors, Estrogen