title: Ascorbic acid, Helicobacter pylori and Lewis phenotype among blacks and whites in New Orleans.
abstract: Gastric juice ascorbic acid concentrations were examined in black and white patients. Significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin C between races. Blacks had higher prevalence of Helicobacter pylori infection, higher gastric pH, more severe acute and chronic inflammation of the gastric mucosa and higher frequency of Lewis (a-b-) phenotype. Although most of these factors have been related to low ascorbic acid levels in gastric juice, none of them could account entirely for the difference between races either individually or after joint consideration. These observations may help to explain the high incidence of gastric carcinoma among the black population in southern Louisiana.
authors.affiliation: Department of Pathology, Louisiana State University Medical Center, New Orleans 70012.
authors.forename: B
authors.initials: B
authors.lastname: Ruiz
authors.forename: P
authors.initials: P
authors.lastname: Correa
authors.forename: E T
authors.initials: ET
authors.lastname: Fontham
authors.forename: J C
authors.initials: JC
authors.lastname: Rood
authors.forename: G T
authors.initials: GT
authors.lastname: Malcom
authors.forename: J
authors.initials: J
authors.lastname: Torrado
authors.forename: A
authors.initials: A
authors.lastname: Perez
authors.forename: T
authors.initials: T
authors.lastname: Ramakrishnan
authors.forename: F M
authors.initials: FM
authors.lastname: Hunter
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D044383:Black People; D005750:Gastric Juice / Q000737:chemistry*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007983:Lewis Blood Group Antigens; D008145:Louisiana; D013274:Stomach Neoplasms / Q000453:epidemiology*; D044465:White People; D001741:Black or African American
chemical_list: D007983:Lewis Blood Group Antigens; D001205:Ascorbic Acid