Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease.
A survey of 8080 subjects was conducted in Baltimore, examining the association between infection with hantaviruses and renal disease. Two groups (N = 6060) with no known risk factors were selected to establish a baseline antibody prevalence. Overall, antibody prevalence was 0.25%. Seroprevalence increased with age, without sex- or race-related differences. Patients with proteinuria showed the same patterns of infection but were more commonly seropositive (1.46%) than the reference group (OR, 3.23; P < .05). Infection among dialysis patients with end-stage renal disease was 2.76%, significantly higher than in the reference group (OR, 5.03; P < .05). In the proteinuria and the dialysis groups, hantavirus infection was consistently associated with a diagnosis of hypertensive renal disease. The association was unrelated to other chronic renal disease diagnoses. Overall, 6.5% of patients with end-stage renal disease due to hypertension were seropositive for a hantavirus. These data suggest that hantavirus infection is associated with hypertensive renal disease.
Glass
G E
GE
Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
Watson
A J
AJ
LeDuc
J W
JW
Kelen
G D
GD
Quinn
T C
TC
Childs
J E
JE
D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D015142:Baltimore / Q000453:epidemiology; D002908:Chronic Disease; D005260:Female; D006476:Orthohantavirus / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D011507:Proteinuria / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006435:Renal Dialysis
D000914:Antibodies, Viral