Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus.
Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor-binding ability. In this study minor receptor-binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act as antigen-presenting cells, although they do not produce a productive infection in murine cells. This binding is specific and can be blocked by other serotypes of minor-group HRV. Pre-treatment of HRV 1A, a minor-group virus, with HRV 1A-specific antibodies inhibited the cellular proliferation of murine virus primed T helper cells, whereas antibody treatment of HRV 15, a non-binding major serotype, gave no inhibition. The cell binding ability of minor-group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major-group viruses in mice.
Hastings
G Z
GZ
Department of Biology, University College, London, GB.
Francis
M J
MJ
Rowlands
D J
DJ
Chain
B M
BM
D000276:Adjuvants, Immunologic; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D009500:Neutralization Tests; D011991:Receptors, Virus / Q000378:metabolism*; D012229:Rhinovirus / Q000276:immunology* / Q000378:metabolism
D000276:Adjuvants, Immunologic; D011991:Receptors, Virus