Electroretinographic effects of haloperidol on the mouse retina.
The effects of haloperidol on the electroretinogram were studied in mice injected intraperitoneally with haloperidol. A dose-related study was performed. A significant decrease in the amplitude of the b-wave was found in the mice injected with more than 20 mg/kg of haloperidol. However, the peak latency of the b-wave and the stimulus intensity required to elicit a b-wave of one half of the maximum b-wave amplitude remained unchanged. No significant changes were found in the a-wave. This change in the electroretinogram recovered 24 hours after the injection. These results suggest that functional change occurred at the retinal level after intraperitoneal injection of haloperidol.
Mizota
A
A
Department of Ophthalmology, Chiba University School of Medicine, Japan.
Adachi-Usami
E
E
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography / Q000187:drug effects*; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051379:Mice; D008813:Mice, Inbred ICR; D012160:Retina / Q000502:physiology*
D006220:Haloperidol