title: Reversal of muscle hypertrophy in the rat urinary bladder after removal of urethral obstruction.
abstract: We studied the ultrastructure of the bladder musculature after first inducing hypertrophy by means of urethral obstruction and subsequently removing the obstruction. With hypertrophy the bladder musculature increases ten-fold or more in volume; after de-obstruction approximately 4/5 of the hypertrophic muscle weight and volume is lost within six weeks. In spite of this very large decrease in muscle mass there is no degeneration of muscle cells or nerve endings or of other cell types in the de-obstructed bladder either at 5 days or at 6 weeks. The individual muscle cells are smaller in size than in the hypertrophic bladder but still larger than control muscle cells. The decrease in muscle cell size is more substantial than the decrease in muscle cell surface. There are no lysosomes or other signs of intracellular degradation in any cells of the muscle layer. The musculature contains a very large amount of intercellular material, mainly collagen. This study documents the great plasticity of the musculature in the reduction of muscle mass after de-obstruction. However, some of the fine structural features are almost as different from the controls as in the hypertrophic muscle.
authors.affiliation: Department of Anatomy and Developmental Biology, University College London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Gabella
authors.forename: B
authors.initials: B
authors.lastname: Uvelius
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006984:Hypertrophy; D008854:Microscopy, Electron; D009130:Muscle, Smooth / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014524:Urethral Obstruction / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D001743:Urinary Bladder / Q000378:metabolism / Q000473:pathology*
chemical_list: D003094:Collagen