[Hydrodynamics of the rabbit eye after general administration of cytostatics].
The aim of the experimental studies, carried-out on 32 rabbits, was to explain the hypotensive effect of cytostatic drugs. It was found that a statistically significant lowering of the intraocular pressure without any changes in the coefficient of the outflow of intraocular fluid occurred on the 1st, 2nd, 3rd and 4th day after administration of cytostatic drugs. On the 2nd and 3rd day, there were also observed a decrease of sodium and an increase of potassium blood concentrations. It ought to be supposed that those changes caused disturbances in Na/K ATP-ase activity with an inhibition of the active transport in the ciliary epithelium and a decrease of the secretion of intraocular fluid in ciliary body.
Kacki
K
K
Klinicznego Oddziału Okulistycznego, Wojskowego Szpitala Klinicznego, Bydgoszczy.
Paradowski
M
M
Goś
R
R
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002924:Ciliary Body / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008727:Methotrexate / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011817:Rabbits; D012964:Sodium / Q000097:blood; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D012964:Sodium; D011188:Potassium; D005472:Fluorouracil; D008727:Methotrexate
Hydrodynamika oka królików po ogólnym podaniu cytostatyków.