title: New-onset asthma after exposure to the steam system additive 2-diethylaminoethanol. A descriptive study.
abstract: Through a leak in the steam heating system, the anticorrosive agent 2-diethylaminoethanol was released into the air of a large office building. Irritative symptoms were experienced by most of the 2500 employees, and 14 workers developed asthma within 3 months of exposure. This study was undertaken to review clinical characteristics of these asthmatics. Environmental exposure monitoring data and medical records were reviewed. Seven of 14 cases were defined as "confirmed" and 7 of 14 as "suspect," using the National Institute for Occupational Safety and Health surveillance case definition of occupational asthma. Spirometry was positive in 4 of 14 of the cases and peak flow testing in 10 of 14. Three cases were diagnosed on the basis of work-related symptoms and physical examination alone. The study suggests that acute exposure to the irritating steam additive 2-diethylaminoethanol was a contributing factor in the development of clinical asthma in this population.
authors.affiliation: New York State Department of Health, Albany 12203.
authors.forename: M E
authors.initials: ME
authors.lastname: Gadon
authors.forename: J M
authors.initials: JM
authors.lastname: Melius
authors.forename: G J
authors.initials: GJ
authors.lastname: McDonald
authors.forename: D
authors.initials: D
authors.lastname: Orgel
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D004196:Disease Outbreaks; D004868:Equipment Failure; D004983:Ethanolamines / Q000009:adverse effects*; D006361:Heating / Q000295:instrumentation*; D006801:Humans; D008875:Middle Aged; D013147:Spirometry
chemical_list: D004983:Ethanolamines; C007369:2-diethylaminoethanol