[The effects of superoxide dismutase on acute myocardial ischemia and lipid peroxidation in rabbits].
There are controversies about the action of superoxide dismutase (SOD) on acute myocardial ischemia, but report about the serial changes of serum malondialdehyde (MDA) levels after myocardial infarction and the relationship between serum levels of MDA and size of myocardial infarct has not yet been found in literature. We made a study, using the acute myocardial infarct model of New Zealand rabbits. The results indicated that SOD significantly reduced the total number of pathologic Q-wave, the myocardial infarct size and serum MDA levels. A significant correlation was found between 48-hour serum MDA levels and 48-hour infarct size. Therefore, it is suggested that free radicals might play an important role in pure acute myocardial ischemic injury; SOD, administered early, could inhibit lipid peroxidation and thus protect the myocardium, and serum MDA levels might be regarded as a specific criterion for the diagnosis of myocardial infarction.
Wang
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Luo
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Chen
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H
Xue
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D000818:Animals; D004562:Electrocardiography; D008026:Ligation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D013482:Superoxide Dismutase / Q000494:pharmacology / Q000627:therapeutic use*
D008315:Malondialdehyde; D013482:Superoxide Dismutase