title: [The virus-inhibiting activity of a preparation obtained from a mussel hydrolysate].
abstract: Antiviral properties were found with a preparation obtained from mussel meat by acid hydrolysis. In the experiments in vitro this mussel hydrolysate reduced the infectious activity of influenza viruses in neutralization tests by 3-6 log. Applications of the preparation to mice infected with a toxigenic influenza virus strain protected from death 66-84% of the animals, the survival rate in controls being from 9 to 16%. The protective effect of mussel hydrolysate was observed both after intranasal and oral administrations. The optimal protective effect was obtained when the preparation was used 5-24 hours before inoculation.
authors.forename: M A
authors.initials: MA
authors.lastname: Bichurina
authors.forename: L E
authors.initials: LE
authors.lastname: Nikitina
authors.forename: M G
authors.initials: MG
authors.lastname: Sovetova
authors.forename: N I
authors.initials: NI
authors.lastname: Rekhina
authors.forename: T V
authors.initials: TV
authors.lastname: Besedina
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Boĭkov
authors.forename: F S
authors.initials: FS
authors.lastname: Noskov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D049872:Bivalvia; D002478:Cells, Cultured; D002642:Chick Embryo; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D008460:Meat; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000401:mortality; D011492:Protein Hydrolysates / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D011492:Protein Hydrolysates
vernacular_title: Virusingibiruiushchaia aktivnost' preparata, poluchennogo iz midiĭnogo gidrolizata.