Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors.
The antimicrobial activities of twenty-two substances structurally related to staurosporine, aglycone in the indolocarbazole and bis-indole series were examined against Streptomyces chartreusis and Streptomyces griseus, Bacillus cereus, Escherichia coli, Candida albicans and Botrytis cinerea. Inhibition of sporulation was examined also on the two species of Streptomyces. Unlike literature reports for efficient protein kinase inhibitors, staurosporine and K-252a, no evident correlation could be found either between protein kinase inhibitory potencies and inhibition of sporulation of the Streptomyces species, or protein kinase inhibitory potencies and growth of all microorganisms tested. A weak activity against C. albicans was observed for the chloro-indolocarbazole compounds as already reported for structurally related substances from the cyanobacterium Tolypothrix tjipanasensis.
Sancelme
M
M
Université Blaise Pascal, Laboratoire de Chimie Organique Biologique, URA 485, Aubière, France.
Fabre
S
S
Prudhomme
M
M
D000470:Alkaloids / Q000494:pharmacology; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D000001:Calcimycin / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D002227:Carbazoles / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D026121:Indole Alkaloids; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019311:Staurosporine; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism; D013305:Streptomyces griseus / Q000187:drug effects
D000470:Alkaloids; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002227:Carbazoles; D026121:Indole Alkaloids; D007211:Indoles; D000001:Calcimycin; C053339:rebeccamycin; C049985:staurosporine aglycone; D011493:Protein Kinase C; D019311:Staurosporine