title: Allele frequencies of Mp6D-9 and GATT markers in 32 Turkish cystic fibrosis families.
abstract: The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the delta F508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.
authors.affiliation: Department of Medical Biology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozgüç
authors.forename: E
authors.initials: E
authors.lastname: Yilmaz
authors.forename: H
authors.initials: H
authors.lastname: Erdem
authors.forename: T
authors.initials: T
authors.lastname: Coşkun
authors.forename: U
authors.initials: U
authors.lastname: Ozçelik
authors.forename: I
authors.initials: I
authors.lastname: Togan
authors.forename: A
authors.initials: A
authors.lastname: Göçmen
authors.forename: S
authors.initials: S
authors.lastname: Ayter
authors.forename: I
authors.initials: I
authors.lastname: Ozalp
mesh_terms: D000483:Alleles; D001483:Base Sequence; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D014421:Turkey
chemical_list: D005819:Genetic Markers; D004247:DNA