[Effect of high doses of tocopherol on the processes of lipid peroxidation and insulin secretion in patients with non-insulin-dependent diabetes mellitus].
Forty-one patients with type II diabetes mellitus were examined, divided into four groups administered various types of treatment: (1) diets, (2) predian, (3) glibenclamide, and (4) sugar-reducing drugs and insulin. All the patients were prescribed vitamin E in daily doses 600 and 1200 mg. The results indicate that vitamin E in high doses stimulates pancreatic insulin-producing function and is conducive to normalization of lipid peroxidation no matter what kind of therapy is administered.
Balabolkin
M I
MI
Mikhaĭlova
E V
EV
Kniazeva
A P
AP
Pankova
S S
SS
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D014810:Vitamin E / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D014810:Vitamin E; D005905:Glyburide
Vliianie bol'nykh doz tokoferola na protsessy perekisnogo okisleniia lipidov i sekretsiiu insulina u bol'nykh insulinnezavisimym sakharnym diabetom.