Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin.
Fumonisins, mycotoxins found on corn and other grains, can act as carcinogens. Recent studies have shown that fumonisin B1 stimulates cell proliferation due to inhibition of sphinganine N-acyl-transferase, an important rate limiting enzymatic step in sphingolipid biosynthesis. Subsequent accumulation of free sphingoid bases in the cell can act as tumor promoters.
Wolf
G
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Department of Nutritional Sciences, University of California, Berkeley.
D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D037341:Fumonisins; D009183:Mycotoxins / Q000633:toxicity*; D013107:Sphingolipids / Q000096:biosynthesis / Q000378:metabolism
D002274:Carcinogens, Environmental; D037341:Fumonisins; D009183:Mycotoxins; D013107:Sphingolipids; C056933:fumonisin B1