title: Examination of fetuses after induced abortion for fetal abnormality--a follow-up study.
abstract: In the North-Western Region we offer a service to examine fetuses aborted after the diagnosis of fetal abnormalities. Many obstetricians use this service. We examined 343 mid-trimester fetuses over the last 5 years: 215 following an abnormal scan and 128 abnormal amniotic fluid or villus findings. When necessary, investigations were performed. A post-mortem examination was always required. As a result of fetal investigation, the scan diagnosis was modified or refined in 91 cases (42.3 per cent). In three of these cases no fetal abnormality was found. For the fetuses diagnosed as abnormal by amniocentesis or chorionic villus biopsy, in one (0.8 per cent) the pre-termination diagnosis was not confirmed. The results were similar to those of our previous 5-year study except (a) diagnosis of neural tube defects was rarely based on amniocentesis in the present study (2/62, 3.2 per cent) compared with the previous one (32/103, 31 per cent), and (b) renal abnormalities were more often diagnosed in the pre-termination scan in the present study. We conclude that the examination of aborted mid-trimester fetuses by dysmorphologists continues to improve diagnosis, allowing more accurate genetic counselling for the families.
authors.affiliation: Regional Genetics Centre, St. Mary's Hospital, Manchester, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Medeira
authors.forename: A
authors.initials: A
authors.lastname: Norman
authors.forename: J
authors.initials: J
authors.lastname: Haslam
authors.forename: J
authors.initials: J
authors.lastname: Clayton-Smith
authors.forename: D
authors.initials: D
authors.lastname: Donnai
mesh_terms: D000028:Abortion, Induced; D000649:Amniocentesis / Q000706:statistics & numerical data; D015193:Chorionic Villi Sampling / Q000706:statistics & numerical data; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy