Biological actions of purines on rat megakaryocytes: potentiation by adenine of the purinoceptor-operated cytoplasmic Ca2+ oscillation.
We have found that adenine enhanced the purinoceptor-operated cytoplasmic Ca2+ oscillation in rat megakaryocytes at submillimolar concentrations. Guanine and other nucleic acid bases had no effect on this system. Adenine enhanced the reaction intensity but had no effect on the threshold concentration of ATP to evoke the oscillation.
Uneyama
C
C
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.
Uneyama
H
H
Takahashi
M
M
Akaike
N
N
D000225:Adenine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D004594:Electrophysiology; D006147:Guanine / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D008533:Megakaryocytes / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011687:Purines / Q000494:pharmacology*; D051381:Rats; D011983:Receptors, Purinergic / Q000187:drug effects*
D007546:Isoquinolines; D015221:Potassium Channels; D011687:Purines; D011983:Receptors, Purinergic; D006147:Guanine; C053177:N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide; D000255:Adenosine Triphosphate; D011493:Protein Kinase C; D000225:Adenine; D002118:Calcium