title: Comparison of oral pulse methotrexate with placebo in the treatment of severe glucocorticosteroid-dependent asthma.
abstract: BACKGROUND
  This study compared the efficacy of weekly oral administration of methotrexate and placebo in treatment of 24 subjects with chronic glucocorticosteroid-dependent asthma.
  
  
  METHODS
  The 33-week randomized, double-blind, placebo-controlled crossover trial compared once weekly 15 mg doses of methotrexate with placebo. At the time of entry, the subjects' mean dosage of prednisone was 23.8 mg/day (range, 12.5 to 85 mg) and glucocorticosteroid therapy had been used continuously for a mean duration of 78 months (range, 5 to 360 months).
  
  
  RESULTS
  Of the 21 subjects who completed the study, 13 tolerated lower daily prednisone doses during methotrexate treatment compared with placebo. When treated with methotrexate, subjects required 14.2% less prednisone than when treated with placebo (p = 0.0447), their subjective symptom scores improved 21.4% (p < 0.05), and mean forced expiratory volume in 1 second values tended to improve. Mean serum theophylline levels did not change significantly between the methotrexate and placebo arms of the study. Adverse effects were minimal, with nausea and headache occurring twice as often during methotrexate therapy compared with placebo.
  
  
  CONCLUSIONS
  Short-term, low-dose, pulse therapy with orally administered methotrexate results in a decrease in the daily glucocorticosteroid requirement in a majority of subjects with severe asthma and is accompanied by improvement in subjective symptom scores without unacceptable side effects or deterioration of pulmonary function.
authors.affiliation: Division of Allergy and Clinical Immunology, University of South Florida, Tampa.
authors.forename: G E
authors.initials: GE
authors.lastname: Stewart
authors.forename: J D
authors.initials: JD
authors.lastname: Diaz
authors.forename: R F
authors.initials: RF
authors.lastname: Lockey
authors.forename: M J
authors.initials: MJ
authors.lastname: Seleznick
authors.forename: W L
authors.initials: WL
authors.lastname: Trudeau
authors.forename: D K
authors.initials: DK
authors.lastname: Ledford
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008168:Lung / Q000502:physiology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011241:Prednisone / Q000627:therapeutic use*; D013806:Theophylline / Q000008:administration & dosage
chemical_list: D010919:Placebos; D013806:Theophylline; D011241:Prednisone; D008727:Methotrexate