title: The use of esmolol to attenuate the haemodynamic response when extubating patients following cardiac surgery--a double-blind controlled study.
abstract: We have assessed the cardiovascular changes associated with emergence from anaesthesia, reversal of neuromuscular blockade and extubation in a group of 14 patients immediately after coronary artery bypass graft surgery had been completed. Patients were randomly allocated to receive either esmolol 500 micrograms.kg-1 over 1 min followed by 100 micrograms.kg-1.min-1 or placebo starting prior to reversal. Significant hypertension and tachycardia occurred in the placebo group, whilst these changes were prevented by the administration of esmolol.
authors.affiliation: Department of Anaesthetics, St Thomas' Hospital, London, U.K.
authors.forename: J P
authors.initials: JP
authors.lastname: O'Dwyer
authors.forename: D
authors.initials: D
authors.lastname: Yorukoglu
authors.forename: M N
authors.initials: MN
authors.lastname: Harris
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000762:Anesthesia Recovery Period; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011412:Propanolamines / Q000008:administration & dosage* / Q000009:adverse effects; D015300:Ventilator Weaning
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol