title: Temporal changes in Trichuris trichiura infection intensity and serum isotype responses in children.
abstract: The present study describes Trichuris trichiura infections in a cohort of children over a period of approximately 5 years, and examines the relationships between changes in infection intensity and changes in parasite-specific isotype responses (measured by ELISA). The decrease in mean infection intensity with time was mirrored by time-dependent changes in IgG subclass responses, with IgA and IgE levels remaining relatively constant in the cohort. At the individual level, changes in infection intensity between the initial and final time-points correlated positively and significantly with changes in all isotype levels with the exception of IgA.
authors.affiliation: Wellcome Research Centre, Department of Biology, Imperial College, London, UK.
authors.forename: C S
authors.initials: CS
authors.lastname: Needham
authors.forename: J E
authors.initials: JE
authors.lastname: Lillywhite
authors.forename: J M
authors.initials: JM
authors.lastname: Didier
authors.forename: A E
authors.initials: AE
authors.lastname: Bianco
authors.forename: D A
authors.initials: DA
authors.lastname: Bundy
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D002675:Child, Preschool; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D010270:Parasite Egg Count; D013997:Time Factors; D014257:Trichuriasis / Q000276:immunology* / Q000469:parasitology; D014258:Trichuris / Q000254:growth & development / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D007132:Immunoglobulin Isotypes