Role of metronidazole in radiation therapy (a review of 717 cancer cases).
The presence of Hypoxic cells in a tumor decreases their radiosensitivity; which blocks the efficacy of external tele cobalt irradiation. So a study was undertaken in various cancer patients to observe the role of metrnidazole as a selective radiosensitizer. 717 cancer cases were enlisted and were divided into a study and control group. The study group were given metronidazole at a dose of 2 grams orally, 4 hours before each irradiation, (5 days in a week) for 6-7 weeks. The control group were devoid of it. After completion of the treatment, as well as, after 3 years follow-up, it was observed that the patients receiving metronidazole had better treatment response and more number of recurrence free years. Since it is a cheaper drug it can be used freely in the form of a potential radiosensitizer, for external irradiation therapy.
Acharya
D K
DK
M.K.C.G. Medical College and Hospital, Berhampur, Ganjam, Orissa Pin.
D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D009062:Mouth Neoplasms / Q000532:radiotherapy; D009369:Neoplasms / Q000532:radiotherapy*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy
D008795:Metronidazole