title: Early detection of post-transplant pancreatic graft dysfunction with technetium-99m-HMPAO scintigraphy.
abstract: We present two cases of compromised pancreatic graft perfusion on a routine 99mTc-HMPAO-scan. The radiopharmaceutical, hexamethylpropyleneamine oxime (HMPAO), labeled with 99mTc-provided high-quality scintigraphic images of transplanted pancreatic grafts. Findings were compared with subsequently performed x-ray digital subtraction angiographs. Pathological examination of both resected grafts revealed venous thrombosis in one case and graft pancreatitis in the other case of disturbed graft perfusion on a 99mTc-HMPAO-scan. While 99mTc-HMPAO scans of pancreatic grafts are not specific for early thrombosis, they seem to be a helpful tool in diagnosing pancreatic dysfunction in general, necessitating further diagnostic steps to elucidate the specific cause.
authors.affiliation: Department of Surgery, University Hospital St. Radboud, Nijmegen, The Netherlands.
authors.forename: L G
authors.initials: LG
authors.lastname: van der Hem
authors.forename: C J
authors.initials: CJ
authors.lastname: van der Linden
authors.forename: C H
authors.initials: CH
authors.lastname: Ticheler
authors.forename: A J
authors.initials: AJ
authors.lastname: Hoitsma
authors.forename: F H
authors.initials: FH
authors.lastname: Corstens
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime