title: Neurotrophic effects of annexin V on cultured neurons from embryonic rat brain.
abstract: Recombinant human annexin V showed survival promoting activity in embryonic rat neocortical and mesencephalic neurons in vitro. The neurotrophic effect was observed from a relatively low dose and in a dose-dependent manner. The neurotrophic activity of annexin V was completely blocked by anti-annexin V antibody. Northern blot analysis demonstrated that annexin V mRNA is expressed in non-neuronal cells in the CNS. These results suggest that annexin V plays certain roles in the CNS as a paracrine-type neurotrophic factor.
authors.affiliation: Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takei
authors.forename: K
authors.initials: K
authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: H
authors.initials: H
authors.lastname: Nakao
authors.forename: A
authors.initials: A
authors.lastname: Iwasaki
authors.forename: S
authors.initials: S
authors.lastname: Kohsaka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017304:Annexin A5 / Q000276:immunology / Q000494:pharmacology*; D001483:Base Sequence; D015152:Blotting, Northern; D001921:Brain / Q000166:cytology* / Q000187:drug effects / Q000196:embryology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D017304:Annexin A5; D012333:RNA, Messenger; D011994:Recombinant Proteins