Pneumocandin D0, a new antifungal agent and potent inhibitor of Pneumocystis carinii.
Pneumocandin D0 (9), a new member of the echinocandin class of antifungal agents, has been isolated as a minor constituent from fermentation broths of the filamentous fungi Zalerion arboricola (ATCC 20957). The structure of 9 has been determined mainly on the basis of spectroscopic analysis and by comparison with published data for similar compounds. To date, pneumocandin D0 has been found to be the most potent inhibitor of Pneumocystis carinii development in vivo within the natural-occurring echinocandin family of antifungal agents.
Morris
S A
SA
Merck Research Laboratories, Rahway, NJ 07065-0900.
Schwartz
R E
RE
Sesin
D F
DF
Masurekar
P
P
Hallada
T C
TC
Schmatz
D M
DM
Bartizal
K
K
Hensens
O D
OD
Zink
D L
DL
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D002177:Candidiasis / Q000188:drug therapy; D054714:Echinocandins; D005285:Fermentation; D051379:Mice; D008815:Mice, Inbred Strains; D003904:Mitosporic Fungi / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D011010:Pneumocystis / Q000187:drug effects*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; C089076:pneumocandin D(0)