[Developmental changes in the concentrations of CSF neurotransmitter metabolites].
Changes in cerebrospinal fluid (CSF) neurotransmitter metabolite concentrations in 32 neurologically normal children aged 0 month to 7 years were analyzed to assess maturation of the central nervous system and compared to CSF from adults. Significant inverse correlations with aging were observed for tryptophan, 5-hydroxyindoleacetic acid, kynurenine, tyrosine, L-dihydroxyphenylalanine, dopamine, homovanillic acid and 3-methoxy-4-hydroxyphenylglycol concentrations. There were no significant differences with aging in CSF serotonin or 3-hydroxykynurenine concentrations. These findings demonstrated that changes in major CSF neurotransmitters occurred with aging during childhood. The importance of age-matched controls in studies of CSF neurotransmitter metabolites in the developing brain was emphasized.
Yamamoto
H
H
Department of Pediatrics, St. Marianna University School of Medicine, Kanagawa.
Egawa
B
B
Horiguchi
K
K
Kaku
A
A
Yamada
K
K
D000328:Adult; D000375:Aging / Q000134:cerebrospinal fluid*; D001921:Brain / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018377:Neurotransmitter Agents / Q000378:metabolism*
D018377:Neurotransmitter Agents