Synthesis and nematocidal activity of arylmercaptovinyltetrahydropyrimidines.
A set of mercaptovinyl tetrahydropyrimidines was synthesized in good yields by lithiation of 1,2-dimethyltetrahydropyrimidine with n-butyl lithium in tetrahydrofurane, followed by condensation with aromatic thioesters. Against three nematode genera, anthelminthic screening shows little activity; 2b and 2d were the most potent against Molinema dessetae.
Kraouti
N
N
Département de Chimie, Faculté de Pharmacie, Toulouse.
Labidalle
S
S
Caujolle
R
R
Payard
M
M
Bories
C
C
Loiseau
P M
PM
Gayral
P
P
D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000969:Antinematodal Agents; D011743:Pyrimidines