Locomotor stereotypy is produced by methylphenidate and amfonelic acid and reduced by haloperidol but not clozapine or thioridazine.
In addition to its well-known behavioral effects in rats, amphetamine also produces patterned locomotion (referred to below as locomotor stereotypy) in an open field. Locomotor stereotypy may be mediated by different mechanisms than those mediating the better-known behavioral effects of amphetamine. To determine whether the ability to produce locomotor stereotypy is an exclusive property of amphetamine or is a property of many amphetamine-like stimulants, several doses of methylphenidate and amfonelic acid were tested. The ability of both atypical and typical neuroleptics to block amphetamine-induced locomotor stereotypy was also tested. Both amfonelic acid and methylphenidate produced some degree of locomotor stereotypy. In addition, amphetamine-induced locomotor stereotypy was reduced by haloperidol but not by clozapine or thioridazine. These data suggest that locomotor stereotypy is more closely related to focused stereotypy than to hyperlocomotion.
Mueller
K
K
Department of Psychology, Texas Christian University, Fort Worth 76129.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008774:Methylphenidate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology
D014150:Antipsychotic Agents; D009287:Naphthyridines; D008774:Methylphenidate; D009268:Nalidixic Acid; D003024:Clozapine; D006220:Haloperidol; D013881:Thioridazine; C006486:amfonelic acid