Genetic linkage of autosomal dominant juvenile glaucoma to 1q21-q31 in three affected pedigrees.
Glaucoma is a common disorder that results in irreversible damage to the optic nerve, causing absolute blindness. In most cases, the optic nerve is damaged by an elevation of the intraocular pressure that is the result of an abnormality in the normal drainage function of the trabecular meshwork. A family history of glaucoma is an important risk factor for the disease, suggesting that genetic defects predisposing to this condition are likely. Three pedigrees segregating an autosomal dominant juvenile glaucoma demonstrated significant linkage to a group of closely spaced markers on chromosome 1. These results confirm the initial mapping of this disease and suggest that this region on chromosome 1 contains an important locus for juvenile glaucoma. We describe recombination events that improve the localization of the responsible gene, reducing the size of the candidate region from 30 to 12 cM.
Wiggs
J L
JL
Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Haines
J L
JL
Paglinauan
C
C
Fine
A
A
Sporn
C
C
Lou
D
D
D000328:Adult; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000097:blood / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005901:Glaucoma / Q000453:epidemiology / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D012307:Risk Factors
D017931:DNA Primers; D004247:DNA