[Plasma levels of the serum antioxidants (uric acid, ceruloplasmin, transferrin) in term and preterm neonates in the first week of life].
Development of serum antioxidants (ceruloplasmin, transferrin, uric acid and bilirubin) an the 1st, 4th, 7th days of life has been evaluated in 50 healthy NGA newborns (25 preterm with 35 +/- 0.6 week of gestational age and 2270 +/- 150 g of weight, 25 a term with 39 +/- 0.8 week of gestational age and 3480 +/- 220 g of weight) and in apparent absence of oxidant stress. The ceruloplasmin values increase from the 1st to 7th days of life and change significantly at the 4th day between a term and preterm newborns (p < 0.01); the transferrin values reduce significantly an the 1st (p < 0.01) and 7th days of life (p < 0.05); the uric acid values reduce in the two groups an the 1st day (p < 0.01). Our results show in the newborn a prevalent antioxidant activity of the studied substances. The plasma levels of uric acid may be compared, in the first week of life, to the hypoxanthine levels as acute ipoxia gauges.
Montagna
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Dipartimento di Biomedicina dell'Età Evolutiva, Università degli Studi di Bari.
Grosso
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Santoro
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Mautone
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D000367:Age Factors; D000975:Antioxidants / Q000032:analysis; D001663:Bilirubin / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis* / Q000502:physiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control; D007231:Infant, Newborn / Q000097:blood* / Q000502:physiology; D007234:Infant, Premature / Q000097:blood* / Q000502:physiology; D008297:Male; D014168:Transferrin / Q000032:analysis* / Q000502:physiology; D014527:Uric Acid / Q000097:blood*
D000975:Antioxidants; D014168:Transferrin; D014527:Uric Acid; D002570:Ceruloplasmin; D001663:Bilirubin
Livelli plasmatici degli antiossidanti sierici (acido urico, ceruloplasmina, transferrina) in neonati a termine e pretermine nella prima settimana di vita.