Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens.
Rats initiated to self-administer 10% ethanol (v/v) in an operant situation using the sucrose-substitution technique received bilateral n. accumbens or caudate nucleus microinjections of d-amphetamine (4, 10, and 20 micrograms/brain), quinpirole (4 micrograms/brain), and/or raclopride (0.1, 0.5, and 1.0 micrograms/brain). Only microinjections into the n. accumbens produced changes in rate and pattern of responding. With d-amphetamine, an increase in total responding and a slowing of initial response rate was seen, whereas with raclopride administration a dose-related decrease in total responding was observed with no alteration in momentary response rates. Drug-dependent behavioral rate and pattern differences suggest that DA activity in the n. accumbens influences ethanol reinforced behavior.
Samson
H H
HH
Alcohol and Drug Abuse Institute, University of Washington, Seattle 98195.
Hodge
C W
CW
Tolliver
G A
GA
Haraguchi
M
M
D000704:Analysis of Variance; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000008:administration & dosage / Q000494:pharmacology*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D019257:Quinpirole; D020891:Raclopride; D051381:Rats; D012054:Reinforcement, Psychology; D012457:Salicylamides / Q000008:administration & dosage / Q000494:pharmacology*; D012646:Self Administration; D013395:Sucrose / Q000494:pharmacology
D015259:Dopamine Agents; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines; D012457:Salicylamides; D019257:Quinpirole; D000431:Ethanol; D020891:Raclopride; D013395:Sucrose; D003913:Dextroamphetamine