title: Role of steroid hormones in potentiating transformation of cervical cells by human papillomaviruses.
abstract: Human papillomaviruses (HPVs) are etiologically involved in cervical neoplasia, and epidemiological evidence suggests that steroid hormones can increase the risk of this cancer in HPV-infected women. Steroids can interact with hormone-response elements in the viral long control region, enhancing HPV transcription and resulting in transformation of cervical cells. Subsequent malignant progression may involve virus-induced chromosomal instability, facilitating viral DNA integration and deregulation of gene expression.
authors.affiliation: Divn of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John's, Canada.
authors.forename: M M
authors.initials: MM
authors.lastname: Pater
authors.forename: R
authors.initials: R
authors.lastname: Mittal
authors.forename: A
authors.initials: A
authors.lastname: Pater
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003907:Dexamethasone / Q000009:adverse effects / Q000633:toxicity; D005260:Female; D006801:Humans; D008954:Models, Biological; D027383:Papillomaviridae / Q000187:drug effects / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000821:virology*; D011374:Progesterone / Q000009:adverse effects / Q000633:toxicity; D013256:Steroids / Q000009:adverse effects* / Q000633:toxicity*; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000821:virology*
chemical_list: D013256:Steroids; D011374:Progesterone; D003907:Dexamethasone