title: [Development of antifactor VIII circulating anticoagulant after surgery of the biliary tract].
abstract: In a 25-year-old woman, admitted with a haemorrhagic syndrome following biliary surgery, an inhibitor of factor VIII was detected. As bleeding was major, she was re-operated on under perioperative administration of the anti-inhibitory coagulant complex Autoplex-T, associated with polyvalent i.v. immunoglobulins. The other therapeutic agents are also considered and their indications discussed, after a review of the circumstances of the diagnosis of this disease.
authors.affiliation: Département d'Anesthésie-Réanimation, CHU de Brabois, Vandoeuve-lés-Nancy.
authors.forename: C
authors.initials: C
authors.lastname: Huraux
authors.forename: M
authors.initials: M
authors.lastname: Hidou
authors.forename: J F
authors.initials: JF
authors.lastname: Perrier
authors.forename: P
authors.initials: P
authors.lastname: Strub
authors.forename: M E
authors.initials: ME
authors.lastname: Briquel
mesh_terms: D000328:Adult; D001662:Biliary Tract Surgical Procedures / Q000009:adverse effects*; D001779:Blood Coagulation Factors / Q000008:administration & dosage; D002763:Cholecystectomy; D015529:Choledochal Cyst / Q000601:surgery; D005169:Factor VIII / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification*
chemical_list: D001779:Blood Coagulation Factors; D007136:Immunoglobulins; C019158:circulating anticoagulants; C025667:prothrombin complex concentrates; D005169:Factor VIII
vernacular_title: Apparition d'un anticoagulant circulant antifacteur VIII après chirurgie de la voie biliare.