Acute and chronic behavioural sequelae resulting from intrastriatal injection of an NMDA agonist.
Unilateral and bilateral injections of cis-2,4-methanoglutamate, a potent and selective NMDA agonist, were made into the striatum of rats. Unilateral injections elicited MK-801-sensitive dose-related increases in contralateral turning, beginning 10-15 min after injection. Bilateral injections elicited typical seizure-like behaviours commencing approximately 80 min postinjection. Forty-eight hours after unilateral injection, and presumably after lesion development, no spontaneous preference for turning was seen. Upon challenge with apomorphine (1 mg/kg SC), ipsilateral turning lasting approximately 60 min was seen. Correlates are drawn between this model and some of the features of Huntington's disease.
Black
M D
MD
Glaxo Institute of Applied Pharmacology, Department of Pharmacology, Cambridge, UK.
Crossman
A R
AR
Hayes
A G
AG
Elliott
P J
PJ
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000502:physiology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects
D005971:Glutamates; D016194:Receptors, N-Methyl-D-Aspartate; C066302:2,4-methanoglutamate; D016291:Dizocilpine Maleate; D001058:Apomorphine