title: Expression of MHC class I antigen in Morris rat hepatoma and normal liver.
abstract: Expression of major histocompatibility complex (MHC) class I antigen in Morris rat hepatoma 7777 and normal rat liver tissues was studied by immunohistochemical techniques, Western blot and radiobinding assay. It was found that hepatoma tissue displayed a pattern of enhanced MHC class I antigen expression compared with normal liver. This phenomenon may represent an uncommon pattern of MHC class I antigen expression of liver tumor. The influence of enhanced MHC class I antigen expression on the development and spread of tumors as well as the possible mechanisms of this enhancement are discussed.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, National University of Singapore.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Yang
authors.forename: P
authors.initials: P
authors.lastname: Mach
authors.forename: L Y
authors.initials: LY
authors.lastname: Cheng
mesh_terms: D000818:Animals; D015153:Blotting, Western; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry* / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000737:chemistry* / Q000276:immunology*; D011869:Radioligand Assay; D051381:Rats; D011915:Rats, Inbred BUF
chemical_list: D015395:Histocompatibility Antigens Class I