Oral piritrexim in advanced bladder cancer: an effective drug after progression on MVAC chemotherapy?
Four patients with advanced or metastatic bladder cancer progressing after MVAC chemotherapy were treated with oral piritrexim. Three of the four patients were evaluable for response, and all three had a partial response to treatment. Piritrexim may be an effective drug for bladder cancer after progression on MVAC chemotherapy.
Feun
L G
LG
Sylvester Comprehensive Cancer Center, University of Miami, Florida 33136.
Savaraj
N
N
Benedetto
P
P
Waldman
S
S
Collier
M
M
Clendennin
N J
NJ
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage
D011743:Pyrimidines; D014747:Vinblastine; D004317:Doxorubicin; C024530:piritrexim; D002945:Cisplatin; D008727:Methotrexate