title: Surgical treatment of acute aortic dissection: efficacy of retrograde cardioplegia for myocardial protection.
abstract: The operative morbidity and mortality of patients with Stanford type A acute aortic dissection undergoing urgent operation using retrograde cardioplegia for myocardial protection were evaluated to assess the efficacy of such surgery. A total of 18 patients (12 men and six women, 19-71 years of age) were operated on 9-137 h after onset of dissection using cardiopulmonary bypass with deep hypothermia and retrograde cardioplegia. Graft replacement was performed in ten patients, primary anastomosis in three, and Cabrol and Bentall operations in five. All patients were weaned from cardiopulmonary bypass, but four died in hospital (mortality rate 22%). Thirteen patients were in good health at follow-up ranging from 3 to 98 months, and the remaining patient died from rectal cancer 5 months after surgery. It is concluded that urgent operation of patients with Stanford type A acute aortic dissection can be performed with reasonable operative and excellent follow-up results. Retrograde cardioplegia is an easy and reliable method of myocardial protection to repair the fragile aortic wall.
authors.affiliation: Department of Cardiovascular Surgery, Akita University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakurada
authors.forename: R
authors.initials: R
authors.lastname: Kuribayashi
authors.forename: S
authors.initials: S
authors.lastname: Sekine
authors.forename: H
authors.initials: H
authors.lastname: Aida
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Abe
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001014:Aortic Aneurysm / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001639:Bicarbonates / Q000008:administration & dosage; D001807:Blood Vessel Prosthesis; D002122:Calcium Chloride / Q000008:administration & dosage; D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D002423:Cause of Death; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D004630:Emergencies; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D008274:Magnesium / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011189:Potassium Chloride / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D015996:Survival Rate
chemical_list: D001639:Bicarbonates; D002314:Cardioplegic Solutions; D011093:Polyethylene Terephthalates; C041711:St. Thomas' Hospital cardioplegic solution; D012965:Sodium Chloride; D011189:Potassium Chloride; D008274:Magnesium; D002122:Calcium Chloride