title: Systemic mastocytosis involving the mandible.
abstract: Systemic mastocytosis is a rare and clinically fascinating disorder that usually involves the skin and hematopoietic tissues. We report a patient with systemic mastocytosis involving the mandible who had no other presenting bone lesions on scintigraphic exam. After noting the radiographic emergence of this osteolytic jaw lesion over a 6-month interval, a biopsy of the lesion was performed, and histologic and electron microscopic studies completed. It is believed that this is the first documented case of mastocytosis to involve an oral-maxillofacial bone. Careful preoperative evaluation and clinical management were conducted to avoid potentially life-threatening complications. A discussion of this condition and strategies for diagnosis and patient management are presented.
authors.affiliation: Department of Veterans Affairs Medical Center, Gainesville, Fla.
authors.forename: R
authors.initials: R
authors.lastname: Medina
authors.forename: R S
authors.initials: RS
authors.lastname: Faecher
authors.forename: D S
authors.initials: DS
authors.lastname: Stafford
authors.forename: D S
authors.initials: DS
authors.lastname: Zander
authors.forename: R A
authors.initials: RA
authors.lastname: Baughman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008415:Mastocytosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate
chemical_list: D013669:Technetium Tc 99m Medronate