Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis.
Borrelia burgdorferi, the causative agent of Lyme disease, is a potent inducer of interleukin-1 beta (IL-1 beta), a cytokine implicated in the pathogenesis of inflammatory arthritis. The balance between IL-1 and the IL-1 receptor antagonist (IL-1ra), a naturally occurring inhibitor of IL-1, might influence disease expression. To explore this possibility, we have done a retrospective study that compared the clinical course of Lyme arthritis in 83 patients with concentrations of IL-1 beta and IL-1ra in the patients' synovial fluid. Patients with high concentrations of IL-1ra and low concentrations of IL-1 beta had rapid resolution of attacks of arthritis, whereas patients with the reverse pattern of cytokine concentrations had long intervals to recovery. Thus, the balance between synovial fluid IL-1 beta and IL-1ra concentrations relates to the time to recovery from an episode of Lyme arthritis.
Miller
L C
LC
Department of Pediatrics, Tufts-New England Medical Center, Boston, Massachusetts 02111.
Lynch
E A
EA
Isa
S
S
Logan
J W
JW
Dinarello
C A
CA
Steere
A C
AC
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008193:Lyme Disease / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012189:Retrospective Studies; D013582:Synovial Fluid / Q000737:chemistry / Q000276:immunology*; D013997:Time Factors
D007375:Interleukin-1; D017472:Receptors, Interleukin-1