Effect of maternal paraquat administration on the fetal ductus arteriosus in the rat.
The ductus arteriosus (DA) in the fetal rat was calibrated using a whole-body freezing method, 3 hr after maternal treatment with paraquat at a dose of 25 mg/kg of body weight on days 19-21 of gestation. On days 20 and 21, the DA was significantly constricted. The DA was also significantly constricted on day 19 2/3 but not on day 19 1/2. It is concluded that paraquat has a constrictive effect on the DA and that the onset of this effect occurs in the first half of day 19 of gestation.
Shirai
M
M
Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Arishima
K
K
Masaoka
T
T
Takagi
H
H
Yamamoto
M
M
Eguchi
Y
Y
Akahori
F
F
D000818:Animals; D002585:Cesarean Section; D004373:Ductus Arteriosus / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005865:Gestational Age; D008297:Male; D008431:Maternal-Fetal Exchange; D010269:Paraquat / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
D010269:Paraquat