title: Reduced vitamin A tolerance in a hyperlipidaemia patient with rapid destructive and hyperostotic osteoarthritis of the hip.
abstract: A 59-year-old patient suffering from hyperlipidaemia developed a chronic vitamin A intoxication syndrome after ingestion of 30000 IE retinol/daily over a period of six years. Functional disability of the right hip was caused by radiologically documented hyperostosis of the acetabular circumference. Finally, a prosthesis had to be implanted because of rapid destructive osteoarthritis of the right hip. Implications of vitamin A for rheumatological management are discussed.
authors.affiliation: Department of Rheumatology and Pathology, University Hospital, Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Theiler
authors.forename: A
authors.initials: A
authors.lastname: Hanck
authors.forename: A
authors.initials: A
authors.lastname: Schreiber
authors.forename: A R
authors.initials: AR
authors.lastname: Von Hochstetter
authors.forename: F J
authors.initials: FJ
authors.lastname: Wagenhaeuser
authors.forename: B A
authors.initials: BA
authors.lastname: Michel
mesh_terms: D004361:Drug Tolerance; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D015576:Hyperostosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006986:Hypervitaminosis A / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014057:Tomography, X-Ray Computed