Oxygenation of locally advanced recurrent rectal cancer, soft tissue sarcoma and breast cancer.
Oxygen tension distributions (pO2) were measured in 20 patients with recurrent soft tissue sarcoma (n = 8), recurrent breast cancer (n = 9) and recurrent rectal cancer (n = 3) using computerized pO2 histography. A total of 35 measurements could be performed pretherapeutically. In 8 measurements there exist some problems with regard to clinical relevant bleeding or uncertainties of the tumor/normal tissue boundary. In general, there is a marked tumor-to-tumor variability even for tumors of the same histology. 5 of 8 soft tissue sarcomas, 1 of 3 recurrent rectal cancers, 4 of 9 breast cancers exhibited pO2 values between zero and 2.5 mmHg, i.e. tissue areas with less than half-maximum radiosensitivity.
Molls
M
M
Department of Radiooncology, Technische Universität München, FRG.
Feldmann
H J
HJ
Füller
J
J
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism; D015687:Cell Hypoxia; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000532:radiotherapy; D010100:Oxygen / Q000378:metabolism*; D011836:Radiation Tolerance; D012004:Rectal Neoplasms / Q000378:metabolism; D012509:Sarcoma / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000378:metabolism
D010100:Oxygen