Neurotoxicity of immunotoxins.
Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to prevent or minimize this toxicity in future clinical trials.
Ilercil
O
O
Biochemistry Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Laske
D W
DW
Walbridge
S
S
Muaszko
K
K
Oldfield
E H
EH
Youle
R J
RJ
D000818:Animals; D001932:Brain Neoplasms / Q000628:therapy; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use / Q000633:toxicity*; D009369:Neoplasms / Q000628:therapy; D014407:Tumor Cells, Cultured
D000922:Immunotoxins