[Heparin-induced extracorporeal LDL precipitation (H.E.L.P.). A new therapeutic possibility in vascular occlusion of the retina--initial results].
Heparin-induced extracorporeal LDL precipitation (HELP) eliminates selectively fibrinogen, LDL cholesterol, cholesterol, triglycerides and LP(a) from the blood plasma using extracorporeal circulation. The reduction of fibrinogen and LDL about 50% after only one procedure immediately improves the hemorrheological situation, which has so far not been achieved by any hemorrheologically active substance. Five patients (1 central retinal vein occlusion, 3 branch vein occlusions, 1 central arterial occlusion) ranging from 59-76 years underwent HELP treatment six times over a 5-week period. After the first HELP procedure the fibrinogen was lowered from 278 +/- 57.8 to 157 +/- 22.2 mg/dl and LDL from 162.2 +/- 58 to 82.4 +/- 32.5 mg/dl. Plasma viscosity decreased from 1.3 +/- 0.07 to 1.1 +/- 0.05 mPa/s. At the end of the treatment an increase in visual acuity of 3 or more lines and an improvement in the visual field was seen in all patients. Measurements of the arteriovenous passage time with laser scan video fluorescein angiography before and at the end of the therapy showed a significant decrease from 3.5 +/- 1.59 to 2.88 +/- 1.54 s (P < 0.05) without influencing the arm-retina time. This first clinical and hemorrheological data on the HELP procedure in retinal vessel occlusion demonstrate a promising regimen in the treatment of acute retinal microcirculatory diseases.
Haas
A
A
Universitäts-Augenklinik, Graz.
Walzl
M
M
Faulborn
J
J
Walzl
B
B
Berglöff
J
J
Eckhardt
M
M
D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D005112:Extracorporeal Circulation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005590:Fractional Precipitation; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015356:Retinal Artery Occlusion / Q000097:blood / Q000628:therapy*; D012170:Retinal Vein Occlusion / Q000097:blood / Q000628:therapy*
D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D005340:Fibrinogen; D006493:Heparin
Heparin-induzierte extrakorporale LDL-Präzipitation (H.E.L.P.). Eine neue Therapiemöglichkeit bei Gefässverschlüssen der Netzhaut--Erste Ergebnisse.