title: Clinical significance of elevated serum soluble interleukin-2 receptor in gastric cancer.
abstract: This is China's pilot study in the assessment of the diagnostic value of serum soluble IL-2 receptor (sIL-2R) in gastric cancer. We measured its level by ELISA method in 45 patients with gastric cancer (without metastasis: 32; with metastasis: 5; recurrence: 8) 27 gastric ulcer, 27 superficial gastritis and 44 healthy controls. The mean-serum sIL-2R levels were significantly elevated in cancer patients, those with metastasis showed even higher levels than those without metastasis. These results suggested that sIL-2R can be used as a marker of host biological response in gastric cancer patients as well as a tumor marker for the diagnosis of the disease.
authors.affiliation: Central Research Laboratory, Shanghai First People's Hospital.
authors.forename: Y F
authors.initials: YF
authors.lastname: Wang
authors.forename: X N
authors.initials: XN
authors.lastname: Wu
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhou
authors.forename: X F
authors.initials: XF
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.forename: H J
authors.initials: HJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2