Heterogeneity of hematopoietic stem cells.
Hematopoietic stem cells are capable of multi-lineage differentiation to all blood cell types as well as self-renewal and radioprotection. Thy-1.1lo Lin-/lo Sca-1+ cells are a heterogeneous mixture of quiescent and self-renewing hematopoietic stem cells as well as multi-lineage expanding cells.
Uchida
N
N
Department of Pathology, Stanford University School of Medicine, California 94305.
Fleming
W H
WH
Alpern
E J
EJ
Weissman
I L
IL
D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D000954:Antigens, Surface / Q000235:genetics; D002454:Cell Differentiation; D015321:Gene Rearrangement; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000196:embryology / Q000254:growth & development; D016130:Immunophenotyping; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D018800:Thy-1 Antigens
D000943:Antigens, Differentiation; D000954:Antigens, Surface; D008562:Membrane Glycoproteins; D018800:Thy-1 Antigens