[Generation of oxygen free radicals by blood leukocytes of children with thrombocytopenic purpura. Regulatory role of products of platelet degranulation].
We studied the free radical status in children with thrombocytopenic purpura. The formation of reactive oxygen species was evaluated using luminol-dependent chemiluminescence. The studied group consisted of 25 children divided in subgroups by the form of the disease and glucocorticoid treatment. We revealed that almost in all cases of the crisis spontaneous and activated chemiluminescence got intensified, though fell to normal values in clinical remission. The diversity of values can be explained by specific features of pathogenesis in different forms of the disease, neutrophil-platelet interactions, the influence of glucocorticoids.
Maĭorova
O A
OA
Deeva
I B
IB
Korkina
L G
LG
Rumiantsev
A G
AG
Soskov
G I
GI
Plakhuta
T G
TG
D001792:Blood Platelets / Q000502:physiology*; D015550:Cell Degranulation / Q000502:physiology*; D002648:Child; D005609:Free Radicals; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D011696:Purpura, Thrombocytopenic / Q000097:blood*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D005609:Free Radicals; D017382:Reactive Oxygen Species
Generatsiia svobodnykh radikalov kisloroda leĭkotsitami krovi deteĭ s trombotsitopenicheskoĭ purpuroĭ. Reguliatornaia rol' produktov degranuliatsii trombotsitov.