[Anticardiolipin syndrome with only skin involvement].
In anticardiolipin syndrome (ACS) a typical antibody constellation is associated with thrombotic and hematologic disorders. Furthermore, recurrent abortion, cerebral ischemia and different skin disorders occur. We report the case of a 29-year-old female suffering for the first time from painful, necrotic deep ulcers on the upper and lower legs and livedo racemosa on the arms as a rare example of a merely cutaneous manifestation of ACS with no demonstrable underlying disease. After systemic treatment with high-dose methylprednisolone, azathioprin and hydrocolloid dressings, healing of the scar tissue occurred. Simultaneously, a maintenance dose of acetylsalicylic acid (100 mg/day) was administered. So far, neither cutaneous relapse nor other signs of ACS have occurred.
Bühler-Singer
S
S
Dermatologische Klinik und Poliklinik, Universität Erlangen-Nürnberg.
von Hintzenstern
J
J
Fartasch
M
M
Hornstein
O P
OP
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D001132:Arm; D001241:Aspirin / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003646:Debridement; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D007871:Leg Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage; D009336:Necrosis; D012867:Skin / Q000473:pathology
D017153:Antibodies, Anticardiolipin; D001379:Azathioprine; D001241:Aspirin; D008775:Methylprednisolone
Anticardiolipin-Syndrom mit alleinigem Hautbefall.