title: Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats.
abstract: The possible role of nitric oxide (NO) on vibrissa-stimulated increase of regional cerebral cerebral blood flow (rCBF) and cerebral metabolic rate of glucose (rCMRglu) was investigated in conscious Wistar rats by using an inhibitor of NO synthase, NG-nitro-L-arginine (NOLAG) at a concentration of 30 mg/kg. In vivo autoradiography distribution with 14C-iodoantipyrine and 14C-deoxyglucose in two separate series showed CBF of 174% of control and CMRglu of 196% of control in the primary sensory cortex opposite the stimulated side in saline treated control animals. Similar increases were found in NOLAG-treated animals. Furthermore, NOLAG did not change either basal CMRglu or CMRO2. The findings suggest, that NO is not involved in coupling flow to the increased metabolism accompanying physiological sensory stimuli.
authors.affiliation: Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital, Denmark.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Kjaer
authors.forename: M B
authors.initials: MB
authors.lastname: Jørgensen
authors.forename: O B
authors.initials: OB
authors.lastname: Paulson
authors.forename: N A
authors.initials: NA
authors.lastname: Lassen
authors.forename: N H
authors.initials: NH
authors.lastname: Diemer
authors.forename: H C
authors.initials: HC
authors.lastname: Lou
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004734:Energy Metabolism / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D019335:Nitroarginine; D051381:Rats; D017208:Rats, Wistar; D014738:Vibrissae / Q000502:physiology*
chemical_list: D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D005947:Glucose