Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined immunodeficiency mouse model.
The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.
Bonnez
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Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.
Rose
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RC
Borkhuis
C
C
Da Rin
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C
Reichman
R C
RC
D000818:Animals; D001483:Base Sequence; D003218:Condylomata Acuminata / Q000821:virology*; D015344:DNA Probes, HPV; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000145:classification / Q000502:physiology*; D010412:Penile Neoplasms / Q000821:virology*; D016511:Severe Combined Immunodeficiency / Q000821:virology; D012867:Skin / Q000821:virology; D016038:Skin Transplantation; D013370:Subrenal Capsule Assay; D013696:Temperature; D014183:Transplantation, Heterologous
D015344:DNA Probes, HPV