Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1.
Ohshima
E
E
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Shizuoka-ken, Japan.
Takami
H
H
Harakawa
H
H
Sato
H
H
Obase
H
H
Miki
I
I
Ishii
A
A
Ishii
H
H
Sasaki
Y
Y
Ohmori
K
K
D000818:Animals; D003990:Dibenzoxepins / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D011982:Receptors, Prostaglandin / Q000187:drug effects; D017482:Receptors, Thromboxane / Q000187:drug effects; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D003990:Dibenzoxepins; D006634:Histamine H1 Antagonists; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D013449:Sulfonamides; D013928:Thromboxane A2; C040624:sulotroban