Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks.
Two antagonists of metabotropic glutamate receptors, L-AP4 and MCPG, were tested in a one-trial passive avoidance task in the chick to investigate whether these receptor subtypes play a role in learning and memory. Drugs were injected i.c. L-AP4 produced amnestic effects when injected pre- or post-training. When injected pretraining, amnesia onset was observed after 1 h post-training. D-AP4 had no effect on memory formation. MCPG in comparison had no effect when injected post-training. When injected pretraining, the onset of amnesia was dose-dependent, ranging from 2 to 1 h post-training. When injecting MCPG along with the mGluR agonist ACPD, no amnestic effect was visible. ACPD on its own had no effect at the dose used.
Hölscher
C
C
Open University, Milton Keynes, UK.
D000613:Aminobutyrates / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001565:Benzoates / Q000494:pharmacology; D002645:Chickens; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D003521:Cyclopropanes; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010768:Phosphoserine / Q000494:pharmacology; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*
D000613:Aminobutyrates; D001565:Benzoates; D003521:Cyclopropanes; D018094:Receptors, Metabotropic Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; C079694:alpha-methyl-4-carboxyphenylglycine; D010768:Phosphoserine; D016291:Dizocilpine Maleate; C012729:2-amino-4-phosphonobutyric acid; D005998:Glycine