title: Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin.
abstract: Fumonisins, mycotoxins found on corn and other grains, can act as carcinogens. Recent studies have shown that fumonisin B1 stimulates cell proliferation due to inhibition of sphinganine N-acyl-transferase, an important rate limiting enzymatic step in sphingolipid biosynthesis. Subsequent accumulation of free sphingoid bases in the cell can act as tumor promoters.
authors.affiliation: Department of Nutritional Sciences, University of California, Berkeley.
authors.forename: G
authors.initials: G
authors.lastname: Wolf
mesh_terms: D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D037341:Fumonisins; D009183:Mycotoxins / Q000633:toxicity*; D013107:Sphingolipids / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D002274:Carcinogens, Environmental; D037341:Fumonisins; D009183:Mycotoxins; D013107:Sphingolipids; C056933:fumonisin B1