Genetic control of polyketide biosynthesis in the genus Streptomyces.
The genetic control of polyketide metabolite biosynthesis in Streptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some two-component sensor kinase-response regulator systems. Translational and posttranslational control mechanisms are only briefly mentioned since very little is known about either of these processes. Examples of how enzyme levels and substrate supply affect polyketide metabolism also are discussed.
Hutchinson
C R
CR
School of Pharmacy, University of Wisconsin, Madison 53706.
Decker
H
H
Madduri
K
K
Otten
S L
SL
Tang
L
L
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D016384:Consensus Sequence; D003630:Daunorubicin / Q000096:biosynthesis; D005663:Furans / Q000138:chemical synthesis*; D005798:Genes, Bacterial; D007783:Lactones / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009876:Operon; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D005663:Furans; D007783:Lactones; D003630:Daunorubicin