[Possible new modulators of the calcium pump of human erythrocytes].
A review on the human erythrocyte Ca pump is presented, discussing general aspects of the catalytic cycle and the effect of some naturally occurring modulators such as calmodulin, acidic phospholipids and polyunsaturated fatty acids, controlled calpain proteolysis and protein kinases. The effect of both ATP, mono and divalent cations and recent experiments by the author and coworkers are also discussed in the same context, pinpointing Ca and Mg as new Ca ATPase modulators.
Romero
P J
PJ
Instituto de Biología Experimental, Fac. Ciencias, Universidad Central de Venezuela, Caracas.
D000255:Adenosine Triphosphate / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
D015220:Calcium Channels; D000255:Adenosine Triphosphate; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases
Posibles nuevos moduladores de la bomba de calcio de los eritrocitos humanos.