Passive transfer of hepatitis antibodies during intravenous administration of immune globulin.
We studied the effect of intravenous immune globulin (IVIG) infusion on the levels of hepatitis B and C antibodies in 10 premature babies. All four tested lots of a commercially purchased IVIG preparation were found to contain substantial amounts of hepatitis B core and hepatitis C antibodies. Our results show that passive transfer of hepatitis B and C virus antibodies occurred after IVIG infusion, and that the levels were dependent on the quantity of IVIG given. When assessing neonates for hepatitis, the factor of receipt of blood products, including IVIG, needs to be considered to interpret laboratory results.
Karna
P
P
Department of Pediatrics and Human Development, Michigan State University, East Lansing.
Murray
D L
DL
Valduss
D
D
Mattarella
N
N
Dyke
J W
JW
Maier
G A
GA
D005865:Gestational Age; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006510:Hepatitis B Antibodies / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D007230:Infant, Low Birth Weight / Q000097:blood / Q000276:immunology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000276:immunology*
D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D016756:Immunoglobulins, Intravenous