title: Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
abstract: Chloroquine resistance in Plasmodium falciparum was reversed in vitro by the neuronal monoamine reuptake inhibitors and antidepressants desipramine, sertraline, fluoxetine, and norfluoxetine but not by carbamazepine, an antiseizure and mood-stabilizing tricyclic drug resembling desipramine which only weakly inhibits neuronal monoamine reuptake. These findings have important clinical implications for drug combination therapy.
authors.affiliation: Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts 02115.
authors.forename: A F
authors.initials: AF
authors.lastname: Coutaux
authors.forename: J J
authors.initials: JJ
authors.lastname: Mooney
authors.forename: D F
authors.initials: DF
authors.lastname: Wirth
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology; D004351:Drug Resistance; D004357:Drug Synergism; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000494:pharmacology; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D020280:Sertraline
chemical_list: D014179:Neurotransmitter Uptake Inhibitors; D005473:Fluoxetine; D002738:Chloroquine; D015057:1-Naphthylamine; C036139:norfluoxetine; D020280:Sertraline; D003891:Desipramine