title: Detection of high-risk human papillomavirus in the cervix and semen of sex partners.
abstract: To investigate the possibility of sexual transmission of human papillomavirus (HPV), 53 married couples were examined for the presence of HPV-16 and -18 DNAs in the uterine cervix and semen using the polymerase chain reaction method. Twenty-three of the 53 women and 12 of the 53 male partners were positive for HPV-16 DNA. No HPV-18 DNA was detected in samples from any of the partners. In 27 pairs, both partners were negative for HPV DNA in cervix or semen; in the remaining 26 pairs, at least 1 of the partners was HPV-16-positive. In 9 (35%) of these 26 pairs, both partners were infected. Furthermore, 9 (75%) of the 12 women with HPV-positive partners were HPV-positive, while 9 (39%) of the 23 men with HPV-positive female partners were HPV-positive. These findings suggest an increased risk of HPV transmission via sexual intercourse, thereby underscoring the importance of preventive care against HPV infection during intercourse.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kyo
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Koyama
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: O
authors.initials: O
authors.lastname: Tanizawa
authors.forename: A
authors.initials: A
authors.lastname: Hakura
mesh_terms: D000328:Adult; D001483:Base Sequence; D002584:Cervix Uteri / Q000821:virology*; D017931:DNA Primers; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008393:Marriage; D008875:Middle Aged; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission; D016133:Polymerase Chain Reaction / Q000379:methods*; D011897:Random Allocation; D012307:Risk Factors; D012661:Semen / Q000821:virology*; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission
chemical_list: D017931:DNA Primers; D004279:DNA, Viral