Malignant rhabdoid tumor of the kidney expresses insulin-like growth factor II transcripts.
Insulin-like growth factor II (IGF-II) is thought to play a major role in fetal growth and development. High levels have been demonstrated in blastemal cells of both normal fetal kidney and Wilms' Tumor (WT). In this report, 2 cases of malignant rhabdoid tumor of the kidney (MRTK) were studied to detect the expression of IGF-II mRNA by in situ hybridization using 35S labelled RNA riboprobes. Results showed highly strong and specific IGF-II mRNA expression by tumor cells.
Sharifah
N A
NA
Department of Pathology, University of Otago Medical School, Dunedin, New Zealand.
Yun
K
K
D002648:Child; D002675:Child, Preschool; D012321:DNA-Directed RNA Polymerases / Q000032:analysis; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D015347:RNA Probes; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012334:RNA, Neoplasm / Q000032:analysis; D018335:Rhabdoid Tumor / Q000235:genetics* / Q000473:pathology
D015347:RNA Probes; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D007335:Insulin-Like Growth Factor II; D012321:DNA-Directed RNA Polymerases