Black-white differences in serum cotinine levels among pregnant women and subsequent effects on infant birthweight.
OBJECTIVE
Higher levels of serum cotinine (a metabolite of nicotine) have been found in Black smokers than in White smokers even after self-reported cigarette dose was controlled. It is unknown whether higher cotinine levels in Black pregnant smokers may increase the risk of delivering an infant of reduced birthweight.


METHODS
We analyzed serum cotinine levels of 374 Black and 829 White women who smoked during pregnancy and who delivered between April 1964 and April 1967. Racial differences in the relationship between cotinine and birthweight were examined.


RESULTS
Cotinine levels were 27.4 ng/mL higher in Black smokers after cigarette dose and confounding variables were controlled. Blacks had higher cotinine levels than Whites at each dose. No significant racial differences in the rate of decrease in birthweight per nanogram of cotinine per milliliter were found.


CONCLUSIONS
Our results confirm previous research showing higher cotinine levels at each smoking dose in Black smokers than in White smokers. Because there was no difference in the rate of decrease in birthweight due to cotinine, our results suggest that cigarette smoking among Blacks may have a greater effect on birthweight than it does among Whites.
English
P B
PB
Maternal and Child Health and Epidemiology Programs, School of Public Health, University of California, Berkeley 94720.
Eskenazi
B
B
Christianson
R E
RE
D001741:Black or African American; D001724:Birth Weight / Q000187:drug effects; D044383:Black People; D015331:Cohort Studies; D003367:Cotinine / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy / Q000097:blood*; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000208:ethnology*; D044465:White People
D003367:Cotinine