Persistent hepatitis C viraemia without liver disease.
In viral infections persistence of the virus is not always associated with virus-induced disease. To find out if active hepatitis C virus (HCV) infection can persist without liver disease we selected four symptom-free individuals with antibodies to HCV but normal aminotransferase levels. They were followed up for 3 years by monthly serology and a liver biopsy was done. At presentation, all four had both antibodies to HCV and circulating HCV RNA. During follow-up their sera remained persistently positive for all HCV antibodies and RNA yet aminotransferase levels did not increase and liver biopsy was normal. These findings indicate that persistent hepatitis C viraemia is not invariably associated with liver damage.
Brillanti
S
S
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
Foli
M
M
Gaiani
S
S
Masci
C
C
Miglioli
M
M
Barbara
L
L
D000328:Adult; D005260:Female; D006526:Hepatitis C / Q000097:blood / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014766:Viremia / Q000473:pathology*