Psychiatric morbidity in adults with hypopituitarism.
Forty-one adults with established hypopituitarism and deficiency of growth hormone (GHD) were compared to an age and sex-matched group with another chronic metabolic disorder (diabetes mellitus) using standardized psychiatric rating and diagnostic measures. Nineteen (46%) of the GHD group were identified as definite psychiatric cases compared with 10 (24%) of the diabetics (odds ratio 1:9:1). The most frequent DSM III-R axis I psychiatric diagnoses were major depression (32% GHD patients and 10% of diabetic patients) and dysthymia. The risk of being a psychiatric case showed an association with duration of illness in the diabetic group, but not in the GHD group. Biochemical indices were not related to the risk of being a case in either group. Hypopituitarism is associated with a higher prevalence of psychiatric disturbance than can be attributed solely to the presence of a chronic disorder.
Lynch
S
S
Academic Department of Psychiatry, St. Mary's Hospital Medical School, London, UK.
Merson
S
S
Beshyah
S A
SA
Skinner
E
E
Sharp
P
P
Priest
R G
RG
Johnston
D G
DG
D000328:Adult; D001007:Anxiety; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000453:epidemiology / Q000523:psychology*; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009770:Obsessive Behavior; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012307:Risk Factors; D013997:Time Factors
D013006:Growth Hormone