title: Stability and compatibility of cisplatin and carboplatin with PVC infusion bags.
abstract: The availability and compatibility of drugs from solutions infused via PVC infusion bags through PVC administration sets have been examined. No significant drug loss was observed during simulated infusions using PVC infusion bags and administration sets over time periods used in hospitals (cisplatin, 2 h; carboplatin, 1 h). The stability of carboplatin was studied in 5% dextrose. In 0.9% NaCl, we observed that carboplatin could be converted to cisplatin in the presence of chloride ions. With cisplatin, no significant difference was found between infusion solutions (5% dextrose or 0.9% NaCl). The stability of cisplatin (5% dextrose or 0.9% NaCl) and carboplatin (5% dextrose) was also studied in PVC bags after storage in the dark at room temperature. The results show that the drugs were stable over the 9-day storage period studied.
authors.affiliation: Laboratoire de Pharmacologie, Pharmacocinétique et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Benaji
authors.forename: T
authors.initials: T
authors.lastname: Dine
authors.forename: M
authors.initials: M
authors.lastname: Luyckx
authors.forename: C
authors.initials: C
authors.lastname: Brunet
authors.forename: F
authors.initials: F
authors.lastname: Goudaliez
authors.forename: M L
authors.initials: ML
authors.lastname: Mallevais
authors.forename: M
authors.initials: M
authors.lastname: Cazin
authors.forename: B
authors.initials: B
authors.lastname: Gressier
authors.forename: J C
authors.initials: JC
authors.lastname: Cazin
mesh_terms: D001672:Biocompatible Materials; D016190:Carboplatin / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D007262:Infusions, Intravenous / Q000295:instrumentation*; D008954:Models, Biological; D011143:Polyvinyl Chloride / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011143:Polyvinyl Chloride; D016190:Carboplatin; D002945:Cisplatin