title: Effect of age and streptozocin concentration on the induction by streptozocin of hyperglycaemia in fasting rats.
abstract: The effect of age and streptozocin concentration on the induction by streptozocin of hyperglycaemia in fasting rats is investigated. The data show that there is a dose dependent effect of streptozocin on the hyperglycaemia induced by streptozocin, and 60 mg/kg streptozocin is significantly more effective than 20 or 40 mg/kg streptozocin in inducing hyperglycaemia. Moreover, the hyperglycaemia induced by 60 mg/kg streptozocin is greater in 8 week old rats than in 4 or 6 week old rats, suggesting an influence of age on streptozocin-induced hyperglycaemia.
authors.affiliation: Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China.
authors.forename: K K
authors.initials: KK
authors.lastname: Wong
authors.forename: H M
authors.initials: HM
authors.lastname: Wu
mesh_terms: D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005215:Fasting; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced*; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D013311:Streptozocin; D006003:Glycogen