title: Hepatitis E virus transmission to a volunteer.
abstract: Hepatitis E virus (HEV) causes an enteric non-A, non-B hepatitis. The disease occurs in epidemic settings and sporadically, and viral transmission is thought to be faecal-oral. We present here a single volunteer study of HEV transmission followed by disease. Clinical and biochemical features of the infection correlated with HEV detection in the stools and sera by reverse transcription/polymerase chain amplification. IgG antibody has persisted for 2 years. The presence of HEV in serum before clinical signs appeared suggests that in endemic areas sporadic transmission of HEV may also occur parenterally.
authors.affiliation: Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A
authors.initials: A
authors.lastname: Chauhan
authors.forename: S
authors.initials: S
authors.lastname: Jameel
authors.forename: J B
authors.initials: JB
authors.lastname: Dilawari
authors.forename: Y K
authors.initials: YK
authors.lastname: Chawla
authors.forename: U
authors.initials: U
authors.lastname: Kaur
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
mesh_terms: D005243:Feces / Q000382:microbiology; D016751:Hepatitis E / Q000382:microbiology / Q000635:transmission*; D016752:Hepatitis E virus / Q000302:isolation & purification; D006801:Humans; D008297:Male