title: Focal necrotising herpes simplex encephalitis: a report of two cases with good clinical and neuropsychological outcomes.
abstract: Two patients with atypical focal necrotising herpes simplex encephalitis are described. They presented with relatively mild clinical disease but despite treatment with acyclovir (10 mg/kg/day for three days in case 1 and 10 days in case 2) they developed dramatic, progressive changes (shown on brain CT) that mimicked space occupying lesions of the temporal lobes. Both patients therefore had a diagnostic and therapeutic temporal lesionectomy followed by further 10 day courses of acyclovir. They subsequently went on to make good clinical and neuropsychological recoveries.
authors.affiliation: Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Counsell
authors.forename: R
authors.initials: R
authors.lastname: Taylor
authors.forename: I R
authors.initials: IR
authors.lastname: Whittle
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology / Q000523:psychology*; D006561:Herpes Simplex / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology*; D006801:Humans; D008297:Male; D009336:Necrosis; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed