title: [A case report of miliary tuberculosis with acute respiratory failure diagnosed by polymerase chain reaction method].
abstract: A 51-year-old male was admitted because of cough and high fever. His chest X-ray and CT revealed miliary shadows, he was administered some antibiotics. But on the 8th day, his chest X-ray revealed ground glass shadows and he was under severe hypoxemia. We suspected miliary tuberculosis with acute respiratory failure due to his clinical course. The intensive therapy with antituberculosis drugs, hydrocortisone (1 g/day) was started and intubation was performed. The smear of the clinical samples did not show acid-fast bacilli on admission. However, by the polymerase chain reaction amplification method specific DNA fragments of Mycobacterium tuberculosis complex were detected from BALF and bone marrow. He was extubated after the 13th day and he recovered. It is difficult to separate and identify tubercle bacilli rapidly, but PCR is available for early diagnosis.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus.
authors.forename: N
authors.initials: N
authors.lastname: Kohagura
authors.forename: S
authors.initials: S
authors.lastname: Yara
authors.forename: T
authors.initials: T
authors.lastname: Oyama
authors.forename: H
authors.initials: H
authors.lastname: Miyagi
authors.forename: F
authors.initials: F
authors.lastname: Higa
authors.forename: J
authors.initials: J
authors.lastname: Inadome
authors.forename: H
authors.initials: H
authors.lastname: Fukuhara
authors.forename: A
authors.initials: A
authors.lastname: Saito
mesh_terms: D000208:Acute Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012131:Respiratory Insufficiency / Q000209:etiology*; D014391:Tuberculosis, Miliary / Q000150:complications / Q000175:diagnosis*