title: [Intraarterial thrombolytic therapy in obliterative thromboangiitis of the lower extremities].
abstract: The article analyses the immediate and late-term results of treatment of patients suffering from thromboangiitis of the lower limbs with acute forms of thromboses of the main arteries and shunts (13 persons) and chronic arterial insufficiency (60 patients). The treatment consisted in intraarterial drug infusion with the use of fibrinolysis activators (celiasa, awelysin) as well as other pathogenetically aimed agents in the form of microcrystal suspensions (hydrocortisone, oxytetracycline, zinc insulin). Regional thrombolysis in acute thrombosis allowed authentic lysis of fresh thrombi in the main arteries in two patients (15%). Local thrombolysis with subsequent course of arterial infusion made possible effective arrest of the local ischemic syndrome in patients with III-IV degree arterial insufficiency and affection of the distal arterial bed and allowed the limb to be preserved during a follow-up period of 2 years in 92.5% of patients.
authors.forename: V B
authors.initials: VB
authors.lastname: Gervaziev
authors.forename: O I
authors.initials: OI
authors.lastname: Kolobova
mesh_terms: D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D005263:Femoral Artery; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010118:Oxytetracycline / Q000627:therapeutic use; D013300:Streptokinase / Q000627:therapeutic use*; D013919:Thromboangiitis Obliterans / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015032:Zinc / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase; D015032:Zinc; D006854:Hydrocortisone; D010118:Oxytetracycline
vernacular_title: Vnutriarterialńaia tromboliticheskaia terapiia pri obliteriruiushchem trombangiite nizhnykh konechnosteĭ.