title: [Synthesis of p-substituted benzoylaminobenzoic acid (methyl esters) and its differentiation induction in activities of human promyelocytic leukemia cells HL-60].
abstract: Sixteen p-substituted benzoylaminobenzoic acids and their methyl esters were synthesized, of which nine were not found in literature. All of the topic compounds were evaluated for their differentiation induction in activities of human promyelotic leukemia cells HL-60. Compounds III1, III2, III4, and III5 possessed potential activities. The differentiation rate, of III4 and III5 was 70% respectively. But it was less than that of retinoic acid (97%).
authors.forename: B
authors.initials: B
authors.lastname: Yu
authors.forename: P
authors.initials: P
authors.lastname: Xu
authors.forename: Z
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D001565:Benzoates