title: Selenium status, fatty acids, vitamins A and E, and aging: the Nove Study.
abstract: To investigate the relationships between aging and selenium status, vitamins A and E, and plasma and erythrocyte fatty acids, we studied 105 healthy subjects (53 women, 52 men) living in Nove, a village near Vicenza (Veneto Region, northern Italy). The subjects were distributed equally for age and sex into four groups: group 1, 20-39 y; group 2, 40-59 y; group 3, 60-75 y; and group 4, > 75 y. A careful selection of subjects to exclude those with chronic or acute diseases was obtained with the collaboration of the three general practitioners operating in Nove. Aging was associated with a progressive decrease in selenium status and in the ratio of plasma and erythrocyte polyunsaturated to saturated fatty acids (P:S). Stepwise multiple linear analysis revealed age, vitamin A, and n-6 polyunsaturated fatty acids (PUFAs) as useful predictors of a substantial proportion of the selenium variability (R = 0.618, R2 = 0.382; P < 0.001) and age and erythrocyte oleic acid as predictors of erythrocyte glutathione peroxidase variability (R = 0.413, R2 = 0.17; P < 0.001).
authors.affiliation: Institute of Medical Pathology, University of Verona, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Olivieri
authors.forename: A M
authors.initials: AM
authors.lastname: Stanzial
authors.forename: D
authors.initials: D
authors.lastname: Girelli
authors.forename: M T
authors.initials: MT
authors.lastname: Trevisan
authors.forename: P
authors.initials: P
authors.lastname: Guarini
authors.forename: M
authors.initials: M
authors.lastname: Terzi
authors.forename: S
authors.initials: S
authors.lastname: Caffi
authors.forename: F
authors.initials: F
authors.lastname: Fontana
authors.forename: M
authors.initials: M
authors.lastname: Casaril
authors.forename: S
authors.initials: S
authors.lastname: Ferrari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood*; D005231:Fatty Acids, Unsaturated; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007558:Italy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009752:Nutritional Status; D012044:Regression Analysis; D012643:Selenium / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium