title: Oral piritrexim in advanced bladder cancer: an effective drug after progression on MVAC chemotherapy?
abstract: Four patients with advanced or metastatic bladder cancer progressing after MVAC chemotherapy were treated with oral piritrexim. Three of the four patients were evaluable for response, and all three had a partial response to treatment. Piritrexim may be an effective drug for bladder cancer after progression on MVAC chemotherapy.
authors.affiliation: Sylvester Comprehensive Cancer Center, University of Miami, Florida 33136.
authors.forename: L G
authors.initials: LG
authors.lastname: Feun
authors.forename: N
authors.initials: N
authors.lastname: Savaraj
authors.forename: P
authors.initials: P
authors.lastname: Benedetto
authors.forename: S
authors.initials: S
authors.lastname: Waldman
authors.forename: M
authors.initials: M
authors.lastname: Collier
authors.forename: N J
authors.initials: NJ
authors.lastname: Clendennin
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D011743:Pyrimidines; D014747:Vinblastine; D004317:Doxorubicin; C024530:piritrexim; D002945:Cisplatin; D008727:Methotrexate