Etonitazene: an opioid selective for the mu receptor types.
Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu 1, mu 2, delta, kappa 1 and sigma receptors. Both etonitazene and morphine displayed a mu 1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies or morphine and etonitazene in various behavioral tests.
Moolten
M S
MS
Department of Pharmacology, University of Massachusetts Medical Center, Worcester 01655.
Fishman
J B
JB
Chen
J C
JC
Carlson
K R
KR
D000595:Amino Acid Sequence; D000818:Animals; D001562:Benzimidazoles / Q000378:metabolism* / Q000494:pharmacology; D006168:Guinea Pigs; D007700:Kinetics; D008969:Molecular Sequence Data; D009020:Morphine / Q000378:metabolism / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D017465:Receptors, Opioid, delta / Q000378:metabolism; D017473:Receptors, Opioid, kappa / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D017480:Receptors, sigma / Q000378:metabolism; D012680:Sensitivity and Specificity
D001562:Benzimidazoles; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; D009020:Morphine