Potentiation of ionophorous anticoccidials with dihydroquinolines: reduction of adverse interactions with antimicrobials.
In two experiments, the compatibility of the anticoccidial combinations of monensin and duokvin, as well as that of maduramicin and duokvin, with some antimicrobials widely used in the broiler production was studied in cockerels. The monensin-duokvin combination was found to be fully compatible with erythromycin, sulphachlorpyrazine, and sulphaquinoxaline. With tiamulin, a slight interaction was observed, but it was far less severe than the toxic interaction between monensin and the diterpene antibiotic. The maduramicin-duokvin combination proved to be compatible with all of the chemotherapeutics tested, including tiamulin. The results of the studies indicate that the adverse interactions of monensin and maduramicin with certain antimicrobials can be considerably diminished or even abolished by using them in reduced doses in combination with the dihydroquinoline compound duokvin.
Laczay
P
P
Department of Pharmacology and Toxicology, University of Veterinary Science, Budapest, Hungary.
Varga
I
I
Mòra
Z
Z
Lehel
J
J
Romvåry
A
A
Semjén
G
G
Fekete
J
J
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D002645:Chickens; D003049:Coccidiostats / Q000633:toxicity*; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007476:Ionophores / Q000633:toxicity*; D007783:Lactones / Q000633:toxicity; D008297:Male; D008985:Monensin / Q000633:toxicity*; D011804:Quinolines / Q000494:pharmacology*
D000890:Anti-Infective Agents; D003049:Coccidiostats; D007476:Ionophores; D007783:Lactones; D011804:Quinolines; C089026:duokvin; C018091:maduramicin; D008985:Monensin