title: The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes.
abstract: The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT effects in a variety of in vitro and in vivo assays. Here, we show that, in contrast to its antagonistic action on NT-induced hypomotility in the rat, SR 48692 failed to antagonize NT-induced hypothermia and analgesia in the mouse and rat. We suggest that these effects might be mediated through a subtype of SR 48692-insensitive NT receptor.
authors.affiliation: Unité de Neuropsychopharmacologie Expérimentale, UA 1170 CNRS, Faculté de Médecine-Pharmacie de Rouen, St-Etienne du Rouvray, France.
authors.forename: I
authors.initials: I
authors.lastname: Dubuc
authors.forename: J
authors.initials: J
authors.lastname: Costentin
authors.forename: J P
authors.initials: JP
authors.lastname: Terranova
authors.forename: M C
authors.initials: MC
authors.lastname: Barnouin
authors.forename: P
authors.initials: P
authors.lastname: Soubrié
authors.forename: G
authors.initials: G
authors.lastname: Le Fur
authors.forename: W
authors.initials: W
authors.lastname: Rostène
authors.forename: P
authors.initials: P
authors.lastname: Kitabgi
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009496:Neurotensin / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D010147:Pain Measurement / Q000187:drug effects; D011720:Pyrazoles; D011804:Quinolines; D051381:Rats; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors* / Q000145:classification*
chemical_list: D000700:Analgesics; D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C079087:SR 48692; D009496:Neurotensin