Post-antibiotic effect of FK-037 and biapenem tested against five bacterial species.
The in-vitro post-antibiotic effect (PAE) was determined for two newer beta-lactams, FK-037 (a cephalosporin) and biapenem (a carbapenem). Our PAE results for these drugs were consistent with what has been reported previously for similar beta-lactams, e.g. Gram-positive organisms had measurable effects (0.4-2.2 hours), while Gram-negatives had variable results (0.0 to 1.4 hours). Even though the PAE test conditions generally coincided with achievable clinical levels for most organisms tested (< or = 4 mg/L for biapenem and < or = 8 mg/L for FK-037), the marginal or species dependent, short PAE values support the selection of multiple daily doses (two-to-four) based on conventional pharmacokinetic parameters such as the Cmax, AUC, and serum elimination half-life.
Houston
A K
AK
Medical Microbiology Division, University of Iowa College of Medicine, Iowa City 52242.
Jones
R N
RN
D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D016972:Enterobacter cloacae / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*
D013845:Thienamycins; C079769:cefoselis; D015296:Ceftizoxime; C065257:biapenem