Ultrastructure of heat-deproteinated compact bone.
Heat-deproteinated bone (calcined bone) is a natural candidate for an osteoreproductive biomaterial. Ultrastructural investigation has pointed out an important aspect of the preparation technique. Treatment of bone at temperatures exceeding 500 degrees C causes complete disruption of the tissue architecture and the reorganization of the mineral phase into tightly packed, dense crystals. At 500 degrees C or less the structure and distribution of the mineral phase remain unaffected, so that cross-banded 'shadows' of collagen fibrils are still readily observable, although collagen is no longer present in the samples. By its excellent structural preservation and natural porosity, low-temperature calcined bone seems to be a promising alternative for osteoreproduction.
Raspanti
M
M
Institute of Human Anatomy, University of Bologna, Italy.
Guizzardi
S
S
De Pasquale
V
V
Martini
D
D
Ruggeri
A
A
D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000648:ultrastructure*; D002417:Cattle; D003460:Crystallization; D005269:Femur; D006358:Hot Temperature; D017348:Microscopy, Electron, Scanning Transmission; D016062:Porosity
D001672:Biocompatible Materials