[Pulmonary surfactant in coal miners].
Healthy coal miners exposed to dust demonstrate the activated synthesis and secretion of surfactant on the alveolar surface, which is and act of defence and is aimed at prevention of the harmful effect of dust on the lung tissue. This idea is proved by the changes in biochemical parameters, such as increase of phospholipids in alveolar lavage and decrease of free fatty acids due to their use in alveolar surfactant synthesis. The stated changes are easily seen in the medium and lower parts of lungs, where the dust is most likely to enter. Surface activity of the lung surfactant is depressed, which is proved by the changed physical parameters of the alveolar lavage. Biochemical and physical parameters of the alveolar lavage could be used to reveal the dust influence on the respiratory system of miners during their work.
Korzh
E V
EV
Valutsina
V M
VM
Miroshnichenko
N I
NI
Bortnikov
K A
KA
Linnik
V I
VI
Lobachev
L M
LM
D000328:Adult; D003032:Coal Mining; D006801:Humans; D008875:Middle Aged; D016272:Occupational Health; D011663:Pulmonary Surfactants / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*
D011663:Pulmonary Surfactants
Sostoianie surfaktanta legkikh u gornorabochikh ugol'nykh shakht.