[An immunoelectron microscopic study of growth hormone secretory granules in human pituitary].
Two fetal and 8 adult pituitaries as well as 12 pituitary growth hormone (GH) cell adenomas were studied with immunoelectron microscopy using immunogold double labelling. The secretory granules in the GH cells were GH-immunoreactive, and there were no differences in size, electron density and morphology among the samples. Large, pleomorphic secretory granules were often seen in the GH cell adenomas: they were GH-immunoreactive and prolactin-negative. The authors except that double labelling with immunogold will be useful for clarifying the nature of the large, pleomorphic secretory granules.
Xue
H
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PUMC Hospital, CAMS and PUMC, Beijing.
D000172:Acromegaly / Q000473:pathology; D000236:Adenoma / Q000648:ultrastructure*; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D005333:Fetus; D017979:Gold Colloid; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D016253:Microscopy, Immunoelectron; D010902:Pituitary Gland / Q000648:ultrastructure*; D010903:Pituitary Gland, Anterior / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000648:ultrastructure*
D017979:Gold Colloid; D013006:Growth Hormone