Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
Wooster
R
R
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.
Neuhausen
S L
SL
Mangion
J
J
Quirk
Y
Y
Ford
D
D
Collins
N
N
Nguyen
K
K
Seal
S
S
Tran
T
T
Averill
D
D
D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D005260:Female; D016161:Genes, Retinoblastoma; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D010641:Phenotype
D005819:Genetic Markers