Phagocytosis of colloidal carbon after administration of perfluorochemicals of first and second generation.
By means of colloidal carbon clearance loading of cells of the reticulo-endothelial system (RES) in rats was estimated after administration of perfluorochemicals. Perfluorocylbromid revealed a significant lower depression of RES function than an equally dosed (g/kg b.wt.) mixture of perfluorodecalin and perfluorotripropylamine. Compared with a magnetometrical measurement of liver macrophage activity, shorter periods of cell loading was determined.
Jäger
L J
LJ
Physiologisches Institut, Universitaet Wuerzburg, Germany.
Lutz
J
J
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D002244:Carbon; D003102:Colloids; D004338:Drug Combinations; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D006842:Hydrocarbons, Brominated; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D008657:Metabolic Clearance Rate; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D001802:Blood Substitutes; D003102:Colloids; D004338:Drug Combinations; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D006895:Hydroxyethyl Starch Derivatives; D002244:Carbon; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; C003072:perflubron