[Effects of dimethylformamide on the monocytophagocytic system of rodents].
The effects of Dimethylformamide (DMF) on monocytophagocytic system (MPS) of rodents were studied. The results showed large dose of DMF (1/20 LD50) with oral administration could significantly inhibit the functions of colloidal carbon clearance of MPS in Wistar rats, and of non-specific phagocytosis of sheep red blood cells (SRBC) by peritoneal macrophage in Kunming mice, and could also lowered significantly the levels of Fc and C3b receptors on the surface of peritoneal macrophage in mice. This showed DMF could cause obvious damage to MPS.
Gao
X Q
XQ
Institute of Labor Hygiene and Occupational Diseases Shandong Academy of Medical Sciences, Ji'nan.
Zhang
W D
WD
Qiao
C B
CB
D000818:Animals; D002244:Carbon / Q000493:pharmacokinetics; D004126:Dimethylformamide / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017463:Receptors, Complement 3b / Q000378:metabolism; D011961:Receptors, Fc / Q000378:metabolism; D012397:Rosette Formation
D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D002244:Carbon; D004126:Dimethylformamide