T-cell-mediated response in Dupuytren's disease.
The cause of Dupuytren's disease is unknown, but inflammatory cells might have a role. Enzymatic digestion of diseased tissue permits identification and immunofluorescent labelling of a cell subset displaying inflammatory cell morphology. Cytofluorimetry of this cell population demonstrated the presence of CD3-positive lymphocytes and expression of major histocompatibility complex (MHC) class II proteins. These results raise the possibility that Dupuytren's disease is a T-cell-mediated autoimmune disorder. The development of medical treatment on this basis may reduce the need for surgery, with its associated morbidity and high recurrence rates.
Baird
K S
KS
Department of Orthopaedic Surgery, University of Glasgow, UK.
Alwan
W H
WH
Crossan
J F
JF
Wojciak
B
B
D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004387:Dupuytren Contracture / Q000276:immunology* / Q000473:pathology; D005205:Fascia / Q000276:immunology; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D006684:HLA-DR Antigens