title: [Fibrinolytic and thrombolytic properties of the drug morikrase].
abstract: Fibrinolytic and thrombolytic properties of morikrase, a complex of proteinases obtained from hepatopancreatic tissues of king crab (Paralithodes camtschatica), were studied in vivo and in vitro. High fibrinolytic activity and dose-dependent activating properties were detected on standard and heated fibrin plates. The preparation maintained its properties during long-term storage at 4 degrees and 22 degrees C. The thrombolytic activity of the drug, affecting the preformed thrombus, was observed both in vitro and in vivo, in rats with experimental thrombosis. Two-phase alteration of the fibrinolytic system and moderate hypocoagulation were found after intravenous administration of morikrase.
authors.forename: G V
authors.initials: GV
authors.lastname: Andreenko
authors.forename: L V
authors.initials: LV
authors.lastname: Liutova
authors.forename: G N
authors.initials: GN
authors.lastname: Rudenskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Karabasova
authors.forename: O G
authors.initials: OG
authors.lastname: Kupenko
authors.forename: V A
authors.initials: VA
authors.lastname: Isaev
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D010450:Endopeptidases / Q000378:metabolism / Q000494:pharmacology*; D004795:Enzyme Stability; D005343:Fibrinolytic Agents / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000378:metabolism / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology; D051381:Rats
chemical_list: D005343:Fibrinolytic Agents; D009097:Multienzyme Complexes; D010450:Endopeptidases; C089174:morikrase
vernacular_title: Fibrinoliticheskie i tromboliticheskie svoĭstva preparata morikrazy.