Expression of P-glycoprotein in relation to clinical manifestation, treatment and prognosis of adrenocortical cancer.
The presence of P-glycoprotein, associated with multiple drug resistance and present in the normal adrenal cortex, was studied in 15 cases of adrenocortical carcinoma. P-glycoprotein was found in eight tumours; no correlation was found with clinical presentation, steroid production or histological index. 10 patients received mitotane. Remarkably, 3 patients with P-glycoprotein-positive tumours achieved complete remission. On the other hand, 2 patients with P-glycoprotein-negative tumours showed progression of the disease despite mitotane treatment. These findings suggest that the expression of P-glycoprotein in adrenocortical carcinoma is not related to clinical manifestations, steroid production, histological index or response to mitotane therapy.
Haak
H R
HR
Department of Internal Medicine, Diaconessenhuis, Eindhoven, The Netherlands.
van Seters
A P
AP
Moolenaar
A J
AJ
Fleuren
G J
GJ
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008939:Mitotane / Q000627:therapeutic use; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D008939:Mitotane