title: The importance of extensive sampling and examination of cervix in suspected cases of amniotic fluid embolism.
abstract: Amniotic fluid embolism is an important complication of pregnancy with high mortality. The diagnosis of amniotic fluid embolism is generally made postmortem and rests upon the histological demonstration of amniotic fluid debris, including foetal epithelial squames and hair, in the pulmonary vasculature. We have made the diagnosis of amniotic fluid embolism in two patients by detection of the amniotic fluid debris in the blood vessels of the cervix in their hysterectomy specimens. These two patients presented with profuse primary postpartum haemorrhage and evidence of disseminated intravascular coagulation after uneventful deliveries. Amniotic fluid debris were only demonstrated in the blood vessels of the cervix but not in the corpus. This observation emphasizes the importance of a thorough histological examination of the cervix in cases of suspected amniotic fluid embolism.
authors.affiliation: Department of Pathology, Queen Mary Hospital, University of Hong Kong.
authors.forename: A N
authors.initials: AN
authors.lastname: Cheung
authors.forename: S C
authors.initials: SC
authors.lastname: Luk
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D004619:Embolism, Amniotic Fluid / Q000473:pathology*; D004630:Emergencies; D005260:Female; D006801:Humans; D007044:Hysterectomy; D006473:Postpartum Hemorrhage / Q000601:surgery; D011247:Pregnancy