title: Sucralfate suspension as a treatment of recurrent aphthous stomatitis.
abstract: METHODS
  A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups.
  
  
  METHODS
  In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years.
  
  
  RESULTS
  After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission.
  
  
  CONCLUSIONS
  Sucralfate suspension should be added to the armament of treatment modalities of RAS.
authors.affiliation: Department of Gastroenterology, Tel Aviv Medical Centre, Sackler School of Medicine, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Rattan
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: N
authors.initials: N
authors.lastname: Arber
authors.forename: M
authors.initials: M
authors.lastname: Gorsky
authors.forename: D
authors.initials: D
authors.lastname: Dayan
mesh_terms: D000278:Administration, Buccal; D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D013392:Sucralfate / Q000008:administration & dosage / Q000627:therapeutic use*; D013535:Suspensions; D016896:Treatment Outcome
chemical_list: D000863:Antacids; D013535:Suspensions; D013392:Sucralfate