Hypothalamic control of water and salt intake and excretion.
This article provides a personal and historical review of research concerning the hypothalamic control of water and salt intake and excretion. The following major points will be considered: 1. Electrical, osmotic, cholinergic, alpha-adrenergic and peptidergic stimulation of the hypothalamus. 2. Determination of the pathways involved in these neuroendocrine responses. 3. The participation of ANP in the control of thirst and salt excretion. 4. The participation of the brain ANPergic neuronal system in ANP release. 5. The role of hypothalamic ANPergic neurons and of sinoaortic and renal baroreceptors in the regulation of volume expansion-induced release of ANP. 6. Effects of the brain ANP system on other hormones.
McCann
S M
SM
Department of Physiology, University of Texas Southwestern Medical Center at Dallas 75235-8873.
Gutkowska
J
J
Franci
C R
CR
Favaretto
A L
AL
Antunes-Rodrigues
J
J
D000804:Angiotensin II / Q000008:administration & dosage / Q000502:physiology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001921:Brain / Q000502:physiology; D002415:Cats; D004285:Dogs; D004326:Drinking / Q000502:physiology*; D006041:Goats; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology; D009318:Natriuresis / Q000502:physiology*; D010121:Oxytocin / Q000502:physiology; D051381:Rats; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D014667:Vasopressins / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*
D012462:Saline Solution, Hypertonic; D014667:Vasopressins; D000804:Angiotensin II; D010121:Oxytocin; D009320:Atrial Natriuretic Factor; D009074:Melanocyte-Stimulating Hormones