title: Spontaneous reperfusion of cerebral infarcts in patients with acute stroke. Incidence, time course, and clinical outcome in the Copenhagen Stroke Study.
abstract: OBJECTIVE
  To determine the incidence, time course, and clinical importance of spontaneous reperfusion of cerebral infarcts in patients with acute stroke.
  
  
  METHODS
  Prospective, community based.
  
  
  METHODS
  Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
  
  
  METHODS
  Included in the incidence and time course study were 354 unselected patients with acute ischemic stroke. Clinical outcome was studied in a subgroup of 36 patients admitted on the day of stroke onset and in whom it was known whether spontaneous reperfusion occurred within the first week after stroke onset.
  
  
  METHODS
  Computed tomography and single photon emission computed tomography, with technetium Tc 99m exametazime used as a flow tracer. The Scandinavian Stroke Scale neurologic score was determined on admission, 1 and 2 weeks after stroke, and at discharge.
  
  
  RESULTS
  The incidence of spontaneous reperfusion was 77% in patients with cortical infarcts. The frequency of reperfusion increased rapidly from zero at the time of onset to 60% on day 7 after stroke, reaching a maximum on day 14, at which time 77% showed reperfusion. Marked clinical improvement was observed in patients with spontaneous reperfusion (P = .001), while no improvement occurred in patients without reperfusion. Reperfusion was not observed in subcortical infarcts.
  
  
  CONCLUSIONS
  The rate of spontaneous reperfusion increases gradually with time and occurs within the first 2 weeks after stroke onset in approximately four of five patients with cortical infarcts. Spontaneous reperfusion seemed to improve clinical outcome.
authors.affiliation: Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
authors.forename: H S
authors.initials: HS
authors.lastname: Jørgensen
authors.forename: B
authors.initials: B
authors.lastname: Sperling
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: H O
authors.initials: HO
authors.lastname: Raaschou
authors.forename: T S
authors.initials: TS
authors.lastname: Olsen
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply; D002544:Cerebral Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous; D014055:Tomography, Emission-Computed