title: The effects of tannic acid on serum and liver lipids of RAIF and RICO rats fed on high fat diet.
abstract: 1. Male genetically hypercholesterolemic (RICO) and normocholesterolemic (RAIF) rats were divided into four groups and each group was fed one of the following diets for 10 weeks: a standard diet (STD); STD supplemented with tannic acid (STD + T); a high fat diet (HFD) and a high fat diet with tannic acid (HFD + T). 2. The RAIF and RICO rats when fed on HFD + T showed beneficial changes in serum lipids compared to the rats fed HFD. The lipid parameters between the groups fed STD and STD + T in both strains were unchanged. 3. The possible modes of hypocholesterolemic action of tannic acid in these rats is discussed.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, National University of Singapore.
authors.forename: T
authors.initials: T
authors.lastname: Yugarani
authors.forename: B K
authors.initials: BK
authors.lastname: Tan
authors.forename: N P
authors.initials: NP
authors.lastname: Das
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000097:blood / Q000187:drug effects; D006938:Hyperlipoproteinemia Type II / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D012016:Reference Values
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D047348:Hydrolyzable Tannins; D008055:Lipids; D006903:Hydroxymethylglutaryl CoA Reductases