Prognostic value of serum immunoglobulin A antibodies to pol gene products during HIV-1 infection.
Serum specimens from 66 HIV-1-infected subjects were tested by ELISA for the presence of IgA antibodies to HIV-1: 44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti-HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and to the level of serum IgA. A significative correlation (P < 0.03) was found between the absence of IgA to the subunit p68 of the reverse transcriptase and a count of CD4+ cell < 400/mm3 or total IgA level over 4.25 g/l. The same pattern was observed for the IgA antibodies to the p52 subunit but the association was just not significant (P < 0.07). No significant decrease was noted for the IgA directed towards the other proteins of HIV-1, especially the products of the gag gene.
Quesnel
A
A
Department of Immunology, Faculty of Medicine Jacques Lisfranc, Saint-Etienne, France.
Pozzetto
B
B
Moja
P
P
Grattard
F
F
Lucht
F R
FR
Touraine
J L
JL
Gaudin
O G
OG
Genin
C
C
D000328:Adult; D000918:Antibody Specificity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015684:Gene Products, pol / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D011379:Prognosis
D015684:Gene Products, pol; D015483:HIV Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G