title: Abnormalities of lung volume at follow-up after antenatal rhesus iso-immunization.
abstract: Rhesus iso-immunization is associated with fatal pulmonary hypoplasia. We have examined the hypothesis that abnormalities of lung volume, as an index of lung growth, may also be found in survivors. At a median age of nine months, lung volume was assessed by measurement of functional residual capacity in 23 patients affected antenatally by rhesus iso-immunization. Seventeen of the patients had required at least one intrauterine transfusion. Five patients (group A) had an FRC < 24 ml/kg (median 21 ml/kg, range 19-22 ml/kg) and the other 18 (group B) an FRC > or = 24 ml/kg (median 27 ml/kg, range 24-36 ml/kg) (p < 0.01). The only significant difference between these two groups was the timing of the first foetal blood sampling and intrauterine transfusion, being a median of 22 weeks (range 20-23 weeks) in group A and 30 weeks (range 17-36 weeks) in group B (p < 0.01).
authors.affiliation: Department of Child Health, King's College Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Greenough
authors.forename: B
authors.initials: B
authors.lastname: Yuksel
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D001805:Blood Transfusion, Intrauterine; D002675:Child, Preschool; D005260:Female; D005315:Fetal Diseases / Q000628:therapy; D005652:Functional Residual Capacity; D005865:Gestational Age; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D012203:Rh Isoimmunization / Q000503:physiopathology* / Q000628:therapy