title: Cardiac nucleotide levels and mitochondrial respiration in copper-deficient rats.
abstract: 1. Male weanling Long-Evans rats were randomly assigned to either copper-adequate (6.0 mg Cu/kg feed) or copper-deficient (< 1.0 mg Cu/kg feed) diets for a 5 week period. 2. Cardiac ATP levels and energy charges did not differ between the two groups. Levels of NAD and phosphocreatine as well as the sum of pyridine nucleotides were greater in copper-deficient rats compared with copper-adequate rats using HPLC analysis. 3. Mitochondrial respiratory control ratios and oxygen consumption rates from copper-deficient rat hearts were depressed, although ADP:O ratios were similar to copper-adequate rat hearts.
authors.affiliation: Department of Human Nutrition and Food Management, Ohio State University, Columbus 43210-1295.
authors.forename: J C
authors.initials: JC
authors.lastname: Chao
authors.forename: D M
authors.initials: DM
authors.lastname: Medeiros
authors.forename: R A
authors.initials: RA
authors.lastname: Altschuld
authors.forename: C M
authors.initials: CM
authors.lastname: Hohl
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003300:Copper / Q000172:deficiency*; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000227:Adenine Nucleotides; D010725:Phosphocreatine; D009243:NAD; D000244:Adenosine Diphosphate; D003300:Copper; D000255:Adenosine Triphosphate