Failure of neutrophils to recover their ability to produce superoxide after stunning by a conventional, acidic, lactate-based peritoneal dialysis solution.
Exposure of human neutrophils to conventional, acidic, lactate-based peritoneal dialysis solutions for 5 minutes results in a depression of superoxide generation. In spite of restoration of extracellular pH to 7.4, these stunned cells failed to recover their ability to generate the anion after a period of an hour.
Ing
T S
TS
Department of Medicine, Veterans Affairs Hospital, Hines, Illinois.
Yu
A W
AW
Podila
P V
PV
Zhou
F Q
FQ
Kun
E W
EW
Strippoli
P
P
Nawab
Z M
ZM
D000328:Adult; D015314:Dialysis Solutions / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010530:Peritoneal Dialysis; D013481:Superoxides / Q000378:metabolism*
D015314:Dialysis Solutions; D007773:Lactates; D013481:Superoxides