Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs.
The effect of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on changes in myocardial energy and carbohydrate metabolism during ischemia was studied. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min during open-chest surgery in anesthetized dogs. The myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered by 3 and 30 min of ischemia, indicating that anaerobic myocardial metabolism had occurred. Amosulalol (0.3 or 1 mg.kg-1) was injected intravenously 5 min before ischemia. Pretreatment with amosulalol, particularly at a dose of 0.3 mg.kg-1, reduced the myocardial energy depletion and the alteration of carbohydrate metabolism induced by ischemia. This result indicates that amosulalol can reduce ischemic influences on the myocardium.
Hayase
N
N
Department of Hospital Pharmacy, Asahikawa Medical College, Japan.
Chiba
K
K
Ichihara
K
K
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000317:Adrenergic alpha-Antagonists / Q000037:antagonists & inhibitors; D000319:Adrenergic beta-Antagonists / Q000037:antagonists & inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005636:Fructosephosphates / Q000378:metabolism; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000378:metabolism*; D000096926:Benzenesulfonamides
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D005636:Fructosephosphates; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates; C027618:fructose-6-phosphate; C032473:amosulalol; D000096926:Benzenesulfonamides