title: Further studies on the adjuvanticity of stearyl tyrosine and amide analogues.
abstract: Stearly tyrosine has been described in the literature as a candidate adjuvant for human vaccines. More recently, other stearyl esters have been reported to be adjuvant-active. This preliminary study assesses the adjuvanticity of stearyl amides, including the amide analogue of stearyl tyrosine: tyrosyl stearylamine. This study indicates that phenylalanylethanolamine O-stearate induces a significant antibody response and a favourable isotype distribution.
authors.affiliation: BioChem Therapeutic Inc., Laval, Québec, Canada.
authors.forename: C L
authors.initials: CL
authors.lastname: Penney
authors.forename: G
authors.initials: G
authors.lastname: Dionne
authors.forename: A
authors.initials: A
authors.lastname: Nixon-George
authors.forename: C A
authors.initials: CA
authors.lastname: Bona
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013228:Stearates / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; C089401:N-(phenylalanyl)ethanolamine O-stearate; C089400:N-(stearyl)tyrosinamide; D013228:Stearates; D014443:Tyrosine; D010649:Phenylalanine; C045245:stearyl tyrosine