title: Complications associated with the treatment of small cell lung cancer.
abstract: Major modalities of treatment in small cell lung cancer include chemotherapy, radiation therapy and surgery and all of these cause both early and late toxicities. Common toxicities, both early and late, are described in all of the modalities of treatment. Emphasis on new approaches such as the use of colony-stimulating factors to reduce myelosuppression, new antiemetics to make cisplatin and anthracyclines much more tolerable, the use of cardiotoxic anthracyclines such as Epirubicin and emphasis on the incidence of second malignancies in this population, some of which will likely decrease due to decreased use of procarbazine and nitrosoureas along with fewer courses of chemotherapy.
authors.affiliation: Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Feld
mesh_terms: D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D018288:Carcinoma, Small Cell / Q000150:complications / Q000628:therapy*; D009202:Cardiomyopathies / Q000209:etiology / Q000517:prevention & control; D003131:Combined Modality Therapy / Q000009:adverse effects; D004066:Digestive System Diseases / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use; D007239:Infections / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control; D008175:Lung Neoplasms / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D011013:Pneumonectomy / Q000009:adverse effects; D011183:Postoperative Complications / Q000209:etiology; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D011878:Radiotherapy / Q000009:adverse effects*; D013908:Thoracotomy / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D007155:Immunologic Factors