Effects of LP-805, a newly developed vasodilator, on myocardial metabolism in ischaemic dog hearts.
The effects of LP-805, a newly developed vasodilator, on changes in the myocardial energy and carbohydrate metabolism induced by ischaemia were studied in open-chest anaesthetized dogs. Ischaemia was induced by ligating the left anterior descending coronary artery for 3 min. The myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered 3 min after the onset of ischaemia. Energy change potential was decreased, and ([G6P] + [F6P])/[FDP] and [lactate]/[pyruvate] ratios were increased by ischaemia. These findings indicated that the myocardial metabolism was converted from an aerobic to an anaerobic type by ischaemia. LP-805 (10, 30, or 100 micrograms kg-1) was injected intravenously 5 min before the onset of ischaemia. LP-805 prevented the myocardial energy depletion and alterations of myocardial carbohydrate metabolism due to ischaemia, indicating that it appeared to convert the anaerobic metabolism back to aerobic metabolism in the ischaemic myocardium. In conclusion, LP-805 may reduce the ischaemic influence on the myocardium.
Ichihara
K
K
Department of Pharmacology, Asahikawa Medical College, Japan.
Morimoto
T
T
Tsujitani
M
M
Abiko
Y
Y
D000227:Adenine Nucleotides / Q000378:metabolism; D000693:Anaerobiosis; D000818:Animals; D050260:Carbohydrate Metabolism; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D011773:Pyruvates / Q000378:metabolism; D014665:Vasodilator Agents / Q000494:pharmacology*
D000227:Adenine Nucleotides; D007773:Lactates; D011720:Pyrazoles; D011743:Pyrimidines; D011773:Pyruvates; D014665:Vasodilator Agents; D010725:Phosphocreatine; C073993:8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile