Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping.
OTF3 (octamer transcription factor 3) is a transcription factor containing a POU-specific domain and a homeodomain that could play a role in early development. In situ hybridization and pairwise linkage analysis showed that OTF3 gene maps close to the human MHC (major histocompatibility complex). In this paper, we define its localization within the MHC, around 100 kb telomeric to HLA-C, using a combination of physical and genetic analyses.
Crouau-Roy
B
B
CRPG CNRS, UPR 8291, CHU Purpan, Toulouse, France.
Amadou
C
C
Bouissou
C
C
Clayton
J
J
Vernet
C
C
Ribouchon
M T
MT
Pontarotti
P
P
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods; D018244:Chromosomes, Artificial, Yeast; D003434:Crossing Over, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics*; D005314:Embryonic and Fetal Development / Q000235:genetics; D005796:Genes; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008285:Major Histocompatibility Complex; D008540:Meiosis; D050814:Octamer Transcription Factor-3; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; D014157:Transcription Factors