title: [Scintigraphy of parathyroid adenomas with 99mTc-sestamibi in an endemic goiter area].
abstract: Recently 99mTc-Sestamibi (MIBI) has been introduced into parathyroid imaging. The purpose of this study was to evaluate the MIBI scan in an endemic goiter area. 25 patients with primary and 9 with secondary hyperparathyroidism (HPT) underwent a MIBI scan one day prior to surgical exploration of the neck. Cervicothoracic planar scintigraphy was performed 5, 15 and 120 min after i.v. injection of 444 MBq of 99mTc-Sestamibi. The MIBI scan correctly detected 20 of 25 adenomas in 25 patients with pHPT. In only 6 of 9 patients with parathyroid hyperplasia a focal uptake was found. The cause of one false-positive result in the control group was an increased MIBI uptake by a follicular adenoma of the thyroid. Parathyroid scintigraphy using 99mTc-Sestamibi as a single radiopharmaceutical is as sensitive in detecting and localizing parathyroid adenomas as the Tl/Tc-scintigraphy. Due to a high prevalence of thyroid adenomas in an endemic goiter area a higher rate of falsely positive results may be expected.
authors.affiliation: Abteilung für Klinische Nuklearmedizin, Klinikums der Philipps-Universität Marburg, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Joseph
authors.forename: U
authors.initials: U
authors.lastname: Welcke
authors.forename: H
authors.initials: H
authors.lastname: Höffken
authors.forename: T
authors.initials: T
authors.lastname: Koppelberg
authors.forename: M
authors.initials: M
authors.lastname: Rothmund
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000601:surgery; D005188:False Negative Reactions; D005189:False Positive Reactions; D006043:Goiter, Endemic / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging*; D007275:Injections, Intravenous; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D015995:Prevalence; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D017256:Technetium Tc 99m Sestamibi
vernacular_title: Szintigraphische Darstellung von Adenomen der Nebenschilddrüse mit 99mTc-Sestamibi in einem Strumaendemiegebiet.