Therapeutic effects and side effects in patients with major depression treated with sulpiride once a day.
The effects of once a day dose of sulpiride efficacy and safety was evaluated in patients with major depressive disorder. The patients received sulpiride once a day in the morning or in the evening. There were no significant differences between two groups in the mean measures of efficacy. Side effects were rare and all of a mild degree. The most common side effects were sedation, constipation, and dryness of mouth. Out of regard for the administrative and psychological advantage of the once a day dosage this form should be preferred in the treatment of major depression.
Tsukamoto
T
T
Department of Psychiatry St. Marianna University, School of Medicine, Kanagawa, Japan.
Asakura
M
M
Tsuneizumi
T
T
Satoh
Y
Y
Shinozuka
T
T
Hasegawa
K
K
D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D013469:Sulpiride / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D013469:Sulpiride