Erythromycin-induced QT prolongation and polymorphic ventricular tachycardia (torsades de pointes): case report and review.
Although uncommon, ventricular arrhythmias associated with erythromycin use have been reported previously, usually in the presence of heart disease and/or situations causing abnormal cardiac electrophysiology (such as bradycardia, hypokalemia, and the administration of other cardioactive drugs). We report a case of QT prolongation and polymorphic ventricular tachycardia (torsades de pointes) that was precipitated by the intravenous administration of erythromycin. In contrast to most other previously described patients, our patient did not demonstrate significant heart disease or other apparent factors contributing to the genesis of the arrhythmia.
Brandriss
M W
MW
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester General Hospital, New York 14621.
Richardson
W S
WS
Barold
S S
SS
D000328:Adult; D004917:Erythromycin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy*; D016171:Torsades de Pointes / Q000139:chemically induced*
D004917:Erythromycin