title: Effects of human growth hormone therapy on melanocytic naevi.
abstract: Melanocytic naevi may grow more rapidly during human growth hormone (hGH) therapy. With standardised skin photographs, the growth rate of the naevi was two-fold greater in 14 hypopituitary and 5 Turner's syndrome girls treated with hGH than in untreated patients or controls. HMB-45 immunoreactivity, a marker of stimulated melanocytes, was absent in naevi from 18 of 19 individuals not treated with hGH, including 5 Turner's syndrome patients studied 2-43 months after stopping hGH. In naevi from 39 hGH-treated patients, 22 showed unusual HMB-45 reactivity in dermal naevocytes. During administration of hGH, melanocytic naevi grow faster and there is reversible stimulation of naevocytes.
authors.affiliation: Department of Paediatrics, University of Liège, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Bourguignon
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
authors.forename: C
authors.initials: C
authors.lastname: Ernould
authors.forename: C
authors.initials: C
authors.lastname: Heinrichs
authors.forename: M
authors.initials: M
authors.lastname: Craen
authors.forename: P
authors.initials: P
authors.lastname: Rochiccioli
authors.forename: J E
authors.initials: JE
authors.lastname: Arrese
authors.forename: C
authors.initials: C
authors.lastname: Franchimont
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000188:drug therapy; D009508:Nevus, Pigmented / Q000150:complications / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*; D014424:Turner Syndrome / Q000150:complications / Q000188:drug therapy
chemical_list: D013006:Growth Hormone