[The value of cognitive psychophysiological studies in a comprehensive approach to schizophrenia (treatment of information and attention capacities in acute-stage schizophrenia)].
According to information processing theory, attention deficits appear to be a nuclear disorder in schizophrenia which the study has been renewed with the development of neurophysiology technique. The originality of our research was to study in a same subject Event-Related-Potentials in three different conditions: passive and active auditory oddball paradigm for Mismatch Negativity (MMN) and P 300, and a simple reaction time task with warming stimulus for the Contingent Negative Variation (CNV). The study was carried out among 20 schizophrenic subjects (paranoid subtype with acute exacerbation, DSM-III-R) and 20 healthy volunteers. Patients differed from controls as the following: a lower amplitude of N1-P2 components of the auditive evoked potentials, a lower amplitude of MMN (absent in 20% of the psychotic subjects), a lower amplitude and a longer latency of P300, and a lower amplitude of CNV. These results suggest a fundamental dysfunction of information processing which involves the early stages of automatic and voluntary attentional cognitive processes in schizophrenia.
Lembreghts
M
M
Laboratoire Universitaire de Psychophysiologie Cognitive Appliquée, Hôpital Le Petit Bourgogne, Liège.
Timsit-Berthier
M
M
D000328:Adult; D000367:Age Factors; D001288:Attention; D003071:Cognition; D003265:Contingent Negative Variation; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012737:Sex Factors
Intérêts de l'exploration en psychophysiologie cognitive dans l'approche compréhensive des schizophrénies (traitement de l'information et capacités attentionnelles dans la schizophrénie en phase aiguë).