[Evaluation of low-flow sevoflurane anesthesia].
Six of twelve ASA 1 or 2 patients were allocated to the low-flow sevoflurane anesthesia group (LFA) and the other 6 to the high-flow sevoflurane anesthesia group (HFA). Sevoflurane consumption of LFA was 1-7th of that of HFA. Soda lime temperature was maintained below 40.0 degrees C and there was no danger of toxic sevoflurane degradation products. The serum inorganic fluoride concentration increased with the rise in % hours (the amount of inhaled sevoflurane in percent multiplied by the length of time under anesthesia in hours), but did not reach the nephrotoxic level of 50 microM in any patient. We conclude that low-flow sevoflurane anesthesia is a safe and clinically useful anesthetic method.
Igarashi
M
M
Department of Anesthesiology, Sapporo Medical University, School of Medicine and Hospital.
Watanabe
H
H
Iwasaki
H
H
Muraki
M
M
Homma
Y
Y
Namiki
A
A
D000328:Adult; D000758:Anesthesia; D000777:Anesthetics / Q000008:administration & dosage / Q000493:pharmacokinetics; D004341:Drug Evaluation; D004987:Ethers / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D005459:Fluorides / Q000097:blood; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D005459:Fluorides