Sequence and structure similarities of cathepsin B from the parasite Schistosoma mansoni and human liver.
A three-dimensional structure of Schistosoma mansoni cathepsin B was modelled using the coordinates of the crystal structure of the human liver enzyme. Both enzymes appear to share remarkable structural similarity. However, an examination of the models complexed with two synthetic inhibitors revealed differences in inhibitor binding, as confirmed by differences in the 50% inhibitory concentration of the same inhibitor.
Klinkert
M Q
MQ
Institute of Cell Biology, Consiglio Nazionale delle Ricerche, Rome, Italy.
Cioli
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D
Shaw
E
E
Turk
V
V
Bode
W
W
Butler
R
R
D000595:Amino Acid Sequence; D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012550:Schistosoma mansoni / Q000201:enzymology*; D017386:Sequence Homology, Amino Acid
D002401:Cathepsin B