title: Disturbances of fluid balance reduce the image quality of bone scintigraphy. Experimental studies in mice.
abstract: The effects of hydration, dehydration and osmotic diuresis on the activity distribution of bone-seeking radiopharmaceuticals have been studied in an experimental mouse system. It was found that any change of the water balance impairs the activity distribution of the radiolabelled phosphonate in the potential bone scintigraphic image. The findings suggest that in order to maintain image quality, elderly patients should not be instructed to drink a large volume of fluid after the administration of a bone-seeking radiopharmaceutical. Further investigations, though, have to be performed in humans.
authors.affiliation: Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Cronhjort
authors.forename: P O
authors.initials: PO
authors.lastname: Schnell
authors.forename: H
authors.initials: H
authors.lastname: Jacobsson
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D004164:Diphosphonates; D004231:Diuresis; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012965:Sodium Chloride / Q000494:pharmacology; D013669:Technetium Tc 99m Medronate; D014018:Tissue Distribution; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D004164:Diphosphonates; D015609:Organotechnetium Compounds; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid; D008353:Mannitol; D012965:Sodium Chloride; D003894:Deamino Arginine Vasopressin; D013669:Technetium Tc 99m Medronate