[Blood ethanol levels and the CTP2E1 C2 allele].
The effect of CYP2E1 upon the blood ethanol level was investigated. Blood ethanol concentrations in 2 volunteers whose ADH2, ADH3 and ALDH2 genotypes were identical, were determined after intravenous administrations of 0.15 g/kg of ethanol by gas chromatography. beta 60 (0.28 mg/ml/hr) of the blood ethanol concentration-time curve in one with the CYP2E1 C2 allele was higher than that (0.25 mg/ml/hr) in the other with no C2 allele. It is possible that the C2 allele may correspond to the higher CYP2E1 activity of ethanol metabolism.
Iwahashi
K
K
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Miyatake
R
R
Suwaki
H
H
Kinoshita
H
H
Ameno
K
K
Ijiri
I
I
Ishikawa
Y
Y
Matsuo
Y
Y
D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000431:Ethanol / Q000097:blood*; D005483:Flushing / Q000235:genetics; D005838:Genotype; D006801:Humans; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; D000444:Aldehyde Dehydrogenase; D010089:Oxidoreductases, N-Demethylating