[Systems for regulating the level of Ca2+, cyclic nucleotides, and reverse absorption of neurotransmitters in isolated nerve endings of the rat brain during development of myocardial infarct].
The systems regulating the levels of Ca(2+)-Mg2+, Ca(2+)-ATPase and potential-dependent absorption of Ca2+ as well as content of cyclic nucleotides, beta-adrenoreceptors, activities of adenylate-, guanylate cyclases and phosphodiesterase were studied in the synaptosomes of rat brain cortex in evolving myocardial infarction. In addition, reverse absorption of noradrenaline, dopamine and serotonin was studied. In one of the animal groups myocardial infarction was simulated after stress. The myocardial infarction, affecting the systems of Ca2+ regulation, caused an increase in reverse absorption of dopamine and serotonin simultaneously with accumulation of lactate in the synaptosomes. In myocardial infarction developed after stress adenylate cyclase was activated, reverse absorption of dopamine was decreased and the content of lactate tended to decrease as compared with the infarction formed without stress effects.
Skurygin
V P
VP
Davidov
V V
VV
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004789:Enzyme Activation; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D018377:Neurotransmitter Agents; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D017301:Ca(2+) Mg(2+)-ATPase; D000262:Adenylyl Cyclases; D006152:Cyclic GMP; D002118:Calcium
Systemy reguliatsii urovnia Ca2+, tsiklicheskikh nukleotidov i obratnoe pogloshchenie neĭrotransmitterov v izolirovannykh nervnykh okanchaniiakh kory golovnogo mozga krys v usloviiakh razvitiia infarkta miokarda.