Towards an understanding of Wilms' tumour.
Many areas of research are contributing to our understanding of WT and the role of WT1 in development of the renal and genitourinary systems. Characterization of putative target genes and the control of their expression continues. The importance of isoform ratios and imprinting effects are also under active investigation, often using animal models. The accumulating mutation data, together with evolutionary studies, illuminate WT1 structure-function relationships, highlighting the regions critical in normal development and tumorigenesis. And last, but by no means least, the hunt for the WT2 and WT3 genes continues.
Williamson
K A
KA
MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland.
Van Heyningen
V
V
D000818:Animals; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D016162:Genes, Wilms Tumor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D009154:Mutation; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics* / Q000473:pathology
D004268:DNA-Binding Proteins; D025721:WT1 Proteins