title: Deranged folic acid metabolism in diabetes-induced rats.
abstract: Metabolic changes in the folic acid and their conjugated polyglutamyl derivatives have been studied in streptozotocin-induced diabetic rats. Conjugated folates which constituted about 70% in normal rat liver get rapidly hydrolysed to simple unconjugated forms as the diabetes progressed leaving behind only 2% after 25 days of the onset of diabetes. Chromatographic analysis shows significant alterations in the formyl- and methyltetrahydrofolate derivatives and their polyglutamylation profiles. A 7-8 fold higher urinary excretion of mainly methyltetrahydrofolate is also observed in diabetic rats.
authors.affiliation: Radiation Biology & Biochemistry Division, Bhabha Atomic Research Centre, Bombay.
authors.forename: M S
authors.initials: MS
authors.lastname: Pote
authors.forename: V
authors.initials: V
authors.lastname: Kesavan
authors.forename: J M
authors.initials: JM
authors.lastname: Noronha
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005492:Folic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005492:Folic Acid