title: [Neoadjuvant treatment with cisplatin, 5-FU and folinic acid in advanced head and neck cancer].
abstract: From May to February 1992, 32 patients diagnosed as advanced cancer of the head and neck were included in a program of neoadjuvant treatment with cisplatin, 5-FU, and folinic acid, followed by radiotherapy (45 at 70 Gy) and/or surgery. Twenty patients were considered fully evaluable; their global response rate was 75% (7 complete responses and 8 partial responses). Five patients had no appreciable response or progression. Radiotherapy after chemotherapy enhanced the response, yielding complete responses in 4 patients and partial response in 1. Toxicity was moderate, except for mucositis (9 cases grade 3-4), despite high doses of drugs and radiotherapy. Given the clinical results, this combination may be promising as a first-line treatment against advanced cancer of the head and neck.
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Regional de Málaga.
authors.forename: J
authors.initials: J
authors.lastname: Contreras
authors.forename: J A
authors.initials: JA
authors.lastname: Medina
authors.forename: A
authors.initials: A
authors.lastname: Albero
authors.forename: I
authors.initials: I
authors.lastname: Herruzo
authors.forename: E
authors.initials: E
authors.lastname: Marina
authors.forename: J M
authors.initials: JM
authors.lastname: Azcoaga
authors.forename: J J
authors.initials: JJ
authors.lastname: Bretón
mesh_terms: D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate
chemical_list: D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil
vernacular_title: Tratamiento neoadyuvante en el cáncer avanzado de cabeza y cuello con cisplatino, 5-fluorouracilo y ácido folínico.