Leishmaniasis of the tongue treated with liposomal amphotericin B.
A 66-year-old man, immunosuppressed because of a lymphoma and with severe ischaemic heart disease and proteinuria, presented with a swelling on the tongue due to leishmaniasis. His travel history suggested that he had acquired the infection in the Mediterranean area some years earlier. He was treated with liposomal amphotericin B for 21 days and made a good recovery despite a temporary deterioration in renal function. Oral lesions are a rare manifestation of Old World leishmaniasis. Liposomal amphotericin B is a novel treatment that may be well tolerated when there is concern about the toxicity of more established drugs.
Baily
G G
GG
Regional Department of Infectious Diseases and Tropical Medicine, Monsall Hospital, Manchester, U.K.
Pitt
M A
MA
Curry
A
A
Haboubi
N Y
NY
Tuffin
J R
JR
Mandal
B K
BK
D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D005455:Fluorescent Antibody Technique; D006801:Humans; D016867:Immunocompromised Host; D007896:Leishmaniasis / Q000188:drug therapy* / Q000473:pathology; D008081:Liposomes; D008297:Male; D014059:Tongue / Q000473:pathology; D014060:Tongue Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology
D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B