Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen.
OBJECTIVE
To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole.


METHODS
Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIB1.


RESULTS
Ki67 immunoreactivity was significantly higher in the tissue from normal first trimester placentas than in that from normal term placentas and spontaneous abortions. Among the 87 patients with hydatidiform moles studied, 20 developed persistent gestational trophoblastic disease and required subsequent treatment. There was no statistically significant difference in the Ki67 index between the 20 patients who developed persistent disease and those who did not.


CONCLUSIONS
Hydatidiform moles which give rise to persistent trophoblastic disease do not have a higher proliferative rate than those which do not. The Ki67 index is not useful for predicting the prognosis of molar pregnancies.
Cheung
A N
AN
Department of Pathology, University of Hong Kong.
Ngan
H Y
HY
Collins
R J
RJ
Wong
Y L
YL
D000022:Abortion, Spontaneous / Q000276:immunology / Q000473:pathology; D000911:Antibodies, Monoclonal; D002455:Cell Division / Q000276:immunology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000276:immunology* / Q000473:pathology; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D009687:Nuclear Proteins / Q000032:analysis* / Q000276:immunology; D010920:Placenta / Q000276:immunology / Q000473:pathology; D011247:Pregnancy; D011379:Prognosis; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins