Evidence for downregulation of hypothalamic 5-hydroxytryptamine receptor function in endurance-trained athletes.
Serum prolactin (PRL) was used as a hormone marker of serotoninergic function following oral administration of an acute dose of a serotoninergic agonist. Five male endurance-trained athletes (ET) and five healthy non-endurance-trained controls (NT) were studied. The peak PRL concentration was lower (P = 0.031) for the ET athletes (486 +/- 208 mU l-1; mean +/- S.D.) than for the NT controls (1000 +/- 385 mU l-1); the total release of PRL was also lower (P = 0.042) for the ET subjects. The lower neuroendocrine response to a serotoninergic agonist in the endurance-trained athletes suggests a downregulation of central serotoninergic receptor function in response to endurance training in man.
Jakeman
P M
PM
Department of Medicine, University of Birmingham.
Hawthorne
J E
JE
Maxwell
S R
SR
Kendall
M J
MJ
Holder
G
G
D000328:Adult; D015536:Down-Regulation; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D010807:Physical Endurance; D011388:Prolactin / Q000097:blood; D011985:Receptors, Serotonin / Q000378:metabolism*; D012016:Reference Values
D011985:Receptors, Serotonin; D011388:Prolactin