[A comparative study of liposome-incorporated beta-lactam antibiotics, fluoroquinolones and cephalosporin conjugates with fluoroquinolones].
Beta-lactam antibiotics (some penicillins and cephalosporins), a fluorquinolone (pefloxacin) and cephalosporin conjugates with fluorquinolones were liposome-encapsulated by the method of detergent dialysis. Under the experimental conditions the entrapment of the beta-lactams and pefloxacin to liposomes did not exceed 20 and 12.5 per cent of the initial quantity respectively. The liposome entrapment of the cephalosporin conjugates with fluorquinolones was much higher. The entrapment of the cefotaxime conjugate with ciprofloxacin amounted to 40 per cent and that of the cefamandol conjugate with pefloxacin amounted to 95 per cent of the initial quantity.
Griaznova
N S
NS
Beliavskaia
I V
IV
Afonin
V I
VI
Zinchenko
E Ia
EIa
Sazykin
Iu O
IuO
Navashin
S M
SM
D000900:Anti-Bacterial Agents / Q000032:analysis*; D000890:Anti-Infective Agents / Q000032:analysis*; D002214:Capsules; D002511:Cephalosporins / Q000032:analysis*; D003902:Detergents; D003956:Dialysis; D004337:Drug Carriers; D004338:Drug Combinations; D024841:Fluoroquinolones; D008081:Liposomes / Q000032:analysis
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002214:Capsules; D002511:Cephalosporins; D003902:Detergents; D004337:Drug Carriers; D004338:Drug Combinations; D024841:Fluoroquinolones; D008081:Liposomes
Sravnitel'noe izuchenie vkliucheniia v liposomy betalaktamnykh antibiotikov, ftorkhinolonov i kon''iugatov tsefalosporinov s ftorkhinolonami.