title: Transcriptional activation of Drosophila homeotic genes from distant regulatory elements.
abstract: In Drosophila the genes responsible for specifying segment identity (the homeotic genes) are transcribed in complex patterns during development. Mutations that mimic loss of homeotic gene activity identify cis-acting DNA sequences and trans-acting proteins required for transcriptional activation. Some of the trans-acting proteins may facilitate interactions between cis-regulatory elements and the promoter by bringing together distant chromosomal elements.
authors.affiliation: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
authors.forename: J A
authors.initials: JA
authors.lastname: Kennison
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators; D014158:Transcription, Genetic
chemical_list: D015534:Trans-Activators