Reduced vitamin A tolerance in a hyperlipidaemia patient with rapid destructive and hyperostotic osteoarthritis of the hip.
A 59-year-old patient suffering from hyperlipidaemia developed a chronic vitamin A intoxication syndrome after ingestion of 30000 IE retinol/daily over a period of six years. Functional disability of the right hip was caused by radiologically documented hyperostosis of the acetabular circumference. Finally, a prosthesis had to be implanted because of rapid destructive osteoarthritis of the right hip. Implications of vitamin A for rheumatological management are discussed.
Theiler
R
R
Department of Rheumatology and Pathology, University Hospital, Basel, Switzerland.
Hanck
A
A
Schreiber
A
A
Von Hochstetter
A R
AR
Wagenhaeuser
F J
FJ
Michel
B A
BA
D004361:Drug Tolerance; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D015576:Hyperostosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006986:Hypervitaminosis A / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014057:Tomography, X-Ray Computed