[A fraction derived from non-protector extract of Leishmania infantum protects Balb/c mice against Leishmania major infection].
We report the identification of a subfraction isolated by gel filtration liquid chromatography from a non-protective Leishmania infantum extract, which protects Balb/c mice against Leishmania major infection, in conjunction with a bacterial adjuvant. Protected mice exhibited cell-mediated immunity, as assessed by increased numbers of CD4+ and CD8+ spleen cells, and the production of IFN gamma, as compared to mice who received only the adjuvant before infection.
Rolland
L
L
Laboratoire de Parasitologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Mookambeswaran Vijayalakshmi
S V
SV
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D000950:Antigens, Ly / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000032:analysis; D018314:Leishmania infantum / Q000737:chemistry*; D018320:Leishmania major; D016773:Leishmaniasis, Cutaneous / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C
D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D007371:Interferon-gamma
Une fraction dérivée d'un extrait non protecteur de Leishmania infantum protège des souris Balb/c contre l'infection à Leishmania major.