Is man helpless against cancer? An environmental approach: antimutagenic agents from Egyptian food and medicinal preparations.
Sixty-two Egyptian food and medicinal preparations were extensively examined for antimutagenic/anticarcinogenic activity using short-term and host-mediated assays. The antimutagenic activity of the substances examined was ranked as follows: thirteen (strong), seven (mild) and five (weak) after metabolic activation. Metabolic activation seems to be necessary for most antimutagenic substances in this study, e.g. radish inhibits 29% of mutagenicity produced in direct antimutagenic assay and inhibits 89% of mutagenicity induced in host-mediated assay.
Badria
F A
FA
Department of Pharmacognosy, Faculty of Pharmacy Mansoura University, Egypt.
D000818:Animals; D016588:Anticarcinogenic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001711:Biotransformation; D004534:Egypt; D005502:Food; D051379:Mice; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology; D010946:Plants, Medicinal
D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D010936:Plant Extracts