title: Unresolved issues in the pathogenesis of Bartter's syndrome and its variants.
abstract: Recent physiologic information concerning the renal response to potassium deprivation has been used to reevaluate potassium wasting in Bartter's syndrome. Experimental patient data support the notion that failure of potassium conservation is due to an imbalance between tubular secretory and reabsorptive processes. Suggestions are presented for the further evaluation of potassium reabsorptive pathways in the distal tubule.
authors.affiliation: Department of Medicine, University of North Carolina, Chapel Hill 27599-7155.
authors.forename: H J
authors.initials: HJ
authors.lastname: Gitelman
mesh_terms: D001477:Bartter Syndrome / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D011188:Potassium / Q000378:metabolism*
chemical_list: D011188:Potassium