title: A double-blind study of neurotropin in patients with acute ischemic stroke.
abstract: Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea-pig. A randomized double-blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo-randomized patients had to be excluded. 10 included patients in the neurotropin and 13 in the placebo-treated group died within the study period of 15 days. A better clinical outcome was observed in the 65 included surviving neurotropin compared with the 56 placebo-treated patients. The size of the infarct and of the oedema zones was significantly more decreased on CT scans from Day 11 compared with Day 3 after stroke in the neurotropin than in the placebo treated group. Neurotropin is helpful in treating brain oedema, related to acute ischemic stroke.
authors.affiliation: Department of Neurology, University Hospital, Ghent, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
authors.forename: D
authors.initials: D
authors.lastname: Decoo
authors.forename: P
authors.initials: P
authors.lastname: Vanderdonckt
authors.forename: A
authors.initials: A
authors.lastname: Dallenga
authors.forename: W
authors.initials: W
authors.lastname: Ceusters
authors.forename: J P
authors.initials: JP
authors.lastname: Kalala
authors.forename: K
authors.initials: K
authors.lastname: De Meulemeester
authors.forename: J
authors.initials: J
authors.lastname: Abdullah
authors.forename: P
authors.initials: P
authors.lastname: Santens
authors.forename: J
authors.initials: J
authors.lastname: Huybrechts
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010919:Placebos; D011134:Polysaccharides / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D011134:Polysaccharides; C010491:neurotropin