[Uncoupling action of fatty acids in liver cells].
Oleate (10-60 microM) stimulates oxygen consumption in hepatocytes in the presence of oligomycin. This stimulation of respiration is partially suppressed by 20 microM carboxyatractylate but is insensitive to 0.5 microM cyclosporin A. The results obtained suggest that fatty acids can uncouple oxidative phosphorylation in hepatocytes and that the uncoupling mechanism is the same as that in isolated mitochondria in the presence of EGTA.
Bobyleva
V A
VA
Mokhova
E N
EN
D000818:Animals; D001278:Atractyloside / Q000031:analogs & derivatives / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D004357:Drug Synergism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology*; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014475:Uncoupling Agents / Q000378:metabolism*
D009829:Oleic Acids; D009840:Oligomycins; D014475:Uncoupling Agents; D001278:Atractyloside; D019301:Oleic Acid; D016572:Cyclosporine; D010100:Oxygen; C003853:carboxyatractyloside
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