title: [A case of congenital protein C deficiency with pulmonary thromboembolism].
abstract: A 47-year-old woman, with a history of recurrent venous thrombosis in her lower limbs (1988 and June, 1992), was admitted because of pulmonary thromboembolism in the right middle lung lobe. She was given anti-coagulant therapy with warfarin. The consolidation in the right middle lobe disappeared within two months. Hematological examinations concerning the coagulation and fibrinolytic system showed a significant decrease in both the serum concentration and the activity of protein C, a vitamin K-dependent hepatic protein which acts as an anticoagulant by shutting off fibrin formation and stimulating fibrinolysis. Since a sister of the patient also has a history of venous thrombosis, several members of her family were tested for protein C deficiency. The familial study revealed that her sister and mother had both a decreased concentration and depressed activity of protein C, indicating that this is a case of congenital protein C deficiency. Warfarin therapy has been continued to reduce the prothrombin time to 70% of the normal control level, resulting in no further episodes of thrombosis.
authors.affiliation: Department of Internal Medicine III, Osaka University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Kumagai
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanio
authors.forename: I
authors.initials: I
authors.lastname: Kawase
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
authors.forename: M
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency; D011517:Prothrombin Time; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D011486:Protein C; D014859:Warfarin