Magnetometric measurements of macrophage activity in the liver after administration of different perfluorochemicals.
The activity of liver macrophages was evaluated using a magnetometric method after administration of different perfluorochemicals. Following treatment with perfluoroctylbromide a significant shorter time period of diminished macrophage activity was found compared with a mixture of perfluorodecalin and perfluorotripropylamine. Results obtained with the magnetometric method on liver macrophages were more sensitive compared with those of colloidal carbon clearance of total body RES.
Koester
M B
MB
Physiologisches Institut, Universitaet Wuerzburg, Germany.
Lutz
J
J
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D004338:Drug Combinations; D004655:Emulsions; D005290:Ferric Compounds; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D006842:Hydrocarbons, Brominated; D006895:Hydroxyethyl Starch Derivatives; D007275:Injections, Intravenous; D007728:Kupffer Cells / Q000187:drug effects* / Q000502:physiology; D008280:Magnetics; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001802:Blood Substitutes; D004338:Drug Combinations; D004655:Emulsions; D005290:Ferric Compounds; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D006895:Hydroxyethyl Starch Derivatives; C001215:ferrite; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; C003072:perflubron