Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite.
Conney
A H
AH
Department of Chemical Biology and Pharmacognsoy, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08855.
Chang
R L
RL
Jerina
D M
DM
Wei
S J
SJ
D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001483:Base Sequence; D001564:Benzo(a)pyrene / Q000378:metabolism* / Q000633:toxicity; D001711:Biotransformation; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008969:Molecular Sequence Data; D016296:Mutagenesis; D009153:Mutagens
D009153:Mutagens; D001564:Benzo(a)pyrene; D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide