Coagulase expression in Staphylococcus aureus is positively and negatively modulated by an agr-dependent mechanism.
Expression of staphylocoagulase by agr+ Staphylococcus aureus depends on the growth phase, being maximal during exponential growth and decreasing sharply postexponentially, while an agr-deleted strain continuously expresses an intermediate level of coagulase. Therefore, coagulase expression appears to be both positively and negatively modulated by an agr-dependent mechanism.
Lebeau
C
C
Département de Recherche en Bactériologie Médicale EA 1655, Faculté de Médecine Alexis Carrel, Lyon, France.
Vandenesch
F
F
Greenland
T
T
Novick
R P
RP
Etienne
J
J
D003030:Coagulase / Q000096:biosynthesis*; D017353:Gene Deletion; D015870:Gene Expression; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D005798:Genes, Bacterial; D005809:Genes, Regulator; D007700:Kinetics; D012333:RNA, Messenger / Q000096:biosynthesis; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D014158:Transcription, Genetic
D003030:Coagulase; D012333:RNA, Messenger