Four-week toxicity study of 4-methoxytoluene in rats.
4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg-1 body weight/day was determined.
Brunsborg
B
B
Institute of Toxicology, National Food Agency, Soeborg, Denmark.
Meyer
O
O
Würtzen
G
G
Olsen
P
P
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005421:Flavoring Agents / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D014508:Urea / Q000097:blood
D000840:Anisoles; D005421:Flavoring Agents; C008412:4-methyl anisole; D014508:Urea; D003404:Creatinine