title: Glomerular lesions in fibrotic kidneys of Norwegian slaughter pigs. Light microscopic and immunohistochemical studies.
abstract: An abattoir survey of renal lesions in Norwegian slaughter pigs demonstrated the presence of a macroscopic evident nephropathy characterised by pale, slightly enlarged and fibrotic kidneys in 143 out of 668 (21.4%) examined carcasses. At light microscopy fibrotic kidneys revealed glomerular lesions characterised by a diffuse mesangial proliferative glomerulopathy. Immunohistochemical examination demonstrated mesangial and paramesangial immune complex deposition containing IgM and C3, and to a lesser degree IgA and IgG in the glomeruli of fibrotic kidneys. Our observation of glomerular lesions caused by immune complex depositions in fibrotic pig kidneys are compared with mesangial nephropathies in man.
authors.affiliation: Department of Morphology, Genetics and Aquatic Biology, Norwegian College of Veterinary Medicine, Oslo.
authors.forename: J H
authors.initials: JH
authors.lastname: Jansen
authors.forename: K
authors.initials: K
authors.lastname: Nordstoga
mesh_terms: D000003:Abattoirs; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D005355:Fibrosis; D005921:Glomerulonephritis / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D009664:Norway; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*
chemical_list: D000936:Antigen-Antibody Complex