Antilipid mediator and antioxidant therapy in adult respiratory distress syndrome.
The adult respiratory distress syndrome is now thought to be caused by or complicated by a variety of mediators for which potential antagonists exist. Lung dysfunction could be prevented by antagonists to metabolites of membrane phospholipids. Examples of such metabolites include thromboxane, prostacyclin, leukotrienes, and platelet-activating factor. Oxidant stress can also produce cytotoxicity through membrane lipid peroxidation, as evidenced by the generation of isoprostanes. N-acetylcysteine, by repletion of the endogenous antioxidant glutathione, may represent a novel approach to the therapy of acute lung injury.
Christman
B W
BW
Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN.
Bernard
G R
GR
D000111:Acetylcysteine / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D011464:Epoprostenol / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation; D007362:Intensive Care Units; D015289:Leukotrienes / Q000627:therapeutic use; D015227:Lipid Peroxidation; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D013931:Thromboxanes / Q000627:therapeutic use; D017211:Treatment Failure
D000305:Adrenal Cortex Hormones; D000975:Antioxidants; D015289:Leukotrienes; D010972:Platelet Activating Factor; D013931:Thromboxanes; D011464:Epoprostenol; D000111:Acetylcysteine