title: Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA.
abstract: We report here the comparative DNA sequence analysis of nearly 100 kilobases of contiguous DNA in the C delta to C alpha region of the alpha/delta T cell receptor loci (TCRAC/TCRDC) of mouse and man. This analysis--the largest genomic sequence comparison so far--provides new insights into the functions of the T cell receptor genes as well as the surrounding chromosome structure through the identification of actively conserved DNA sequences. In this comparison we have identified a very high level of organizational and noncoding sequence similarity (approximately 71%) in contrast to previous findings in the beta-globin gene cluster. This observation begins to question the notion that much of the chromosomal non-coding sequence is junk.
authors.affiliation: Department of Biology, University of Victoria, British Columbia, Canada.
authors.forename: B F
authors.initials: BF
authors.lastname: Koop
authors.forename: L
authors.initials: L
authors.lastname: Hood
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005796:Genes; D006801:Humans; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
chemical_list: D011948:Receptors, Antigen, T-Cell