title: Cervical carcinoma in young patients: clinical and pathological variables.
abstract: Twenty-five (10.2%) out of 243 untreated patients with invasive cervical carcinoma were 35 years old or younger. When matching the clinical and pathological variables between the younger and the older women, the former were characterized by a higher rate of Stage IB disease (P = 0.10), G3 and G4 tumors (P = 0.25), bulky lesions (P = 0.05) and node metastases (P = 0.50). In spite of this poorer pathological profile, both the 5-year disease-free survival rate (75%) and survival according to stage of the younger women were similar to those reported in larger series, regardless of the patients' age. No modification of the standard therapy is therefore required in younger patients.
authors.affiliation: Department of Gynecologic Oncology, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Mariani
authors.forename: A
authors.initials: A
authors.lastname: Iacovelli
authors.forename: C
authors.initials: C
authors.lastname: Vincenzoni
authors.forename: F F
authors.initials: FF
authors.lastname: Diotallevi
authors.forename: M
authors.initials: M
authors.lastname: Atlante
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
mesh_terms: D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy