[The histology of mastopathy and cumulative ipsilateral breast cancer sequence].
In a retrolective and follow-up study the ipsilateral cumulative risk of breast carcinoma after histological benign diseases in women under 66 years of age (n = 1397) is investigated. The subtypes are mastopathy I (= changes without proliferative lesions), mastopathy II (= proliferative lesions without atypia), and mastopathy III (id sunt atypical ductal and lobular hyperplasias). The cumulative risk with mastopathy I and II over a 15 year time period corresponds with the ordinary age related risk, the cumulative risk with mastopathy III is four times higher (p = 0.001). There is no difference between atypical ductal and lobular hyperplasia (p = 0.7). Women in reproductive age have a higher risk (p = 0.03), which exists even after a carcinoma-free survival of more than 10 years. The mastopathy is more a stigma for a higher breast cancer risk than a direct precancerous lesion.
Prechtel
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K
Gehm
O
O
Geiger
G
G
Prechtel
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000145:classification / Q000401:mortality / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000145:classification / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000145:classification / Q000401:mortality / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000145:classification / Q000401:mortality / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000145:classification / Q000401:mortality / Q000473:pathology*; D012307:Risk Factors; D015996:Survival Rate
Die Histologie der Mastopathie und die kumulative ipsilaterale Mammakarzinomsequenz.