On the effect of ageing on the distribution of vasoactive intestinal polypeptide and calcitonin gene-related peptide in the rat brain.
The distribution of calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) was investigated by the use of immunohistochemical techniques in the brain of young and aged rats. CGRP-like immunoreactivity (CGRP-LI) showed a significant decrease only in the amygdala, whereas a substantial age-dependent decrease in VIP-like immunoreactivity (VIP-LI) was observed in the cortex, amygdala, substantia nigra, hippocampus and suprachiasmatic nucleus.
Andreose
J S
JS
Department of Pharmacology, School of Medicine, University of Milano, Italy.
Fumagalli
G
G
Clementi
F
F
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology / Q000378:metabolism*; D015536:Down-Regulation / Q000502:physiology; D007150:Immunohistochemistry; D051381:Rats; D011921:Rats, Inbred WKY; D014660:Vasoactive Intestinal Peptide / Q000276:immunology / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide