title: Pre-emptive administration of corticosteroids prevents the development of ARDS associated with Streptococcus mitis bacteremia following chemotherapy with high-dose cytarabine.
abstract: Adult respiratory distress syndrome (ARDS) complicating Streptococcus mitis bacteremia is a major cause of mortality in patients undergoing therapy for leukemia. In order to try to prevent the development of ARDS in 11 patients with S. mitis bacteremia following chemotherapy including cytarabine, high doses of corticosteroids were administered pre-emptively. None of these patients developed ARDS. In a historical control group of 21 comparable patients who had not been given corticosteroids, the incidence of ARDS was high (38%), with a death rate of 14%. Preemptive administration of high-dose corticosteroids appeared to be highly effective in suppressing the mechanisms that induce ARDS in patients with S. mitis bacteremia after cytarabine treatment. The results suggest that ARDS complicating S. mitis bacteremia is not merely a microbiological problem but may, at least in part, represent an immunologically mediated phenomenon.
authors.affiliation: Division of Hematology, University Hospital St. Radboud, Nijmegen, The Netherlands.
authors.forename: E C
authors.initials: EC
authors.lastname: Dompeling
authors.forename: J P
authors.initials: JP
authors.lastname: Donnelly
authors.forename: J M
authors.initials: JM
authors.lastname: Raemaekers
authors.forename: B E
authors.initials: BE
authors.lastname: De Pauw
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000382:microbiology* / Q000517:prevention & control*; D013290:Streptococcal Infections / Q000150:complications* / Q000188:drug therapy / Q000209:etiology
chemical_list: D000305:Adrenal Cortex Hormones; D003561:Cytarabine