The retinoblastoma gene and its significance.
The first human tumour suppressor gene, the Retinoblastoma Susceptibility gene (RB1) was first demonstrated in retinoblastoma, a rare paediatric eye tumour which has been studied extensively over the last century. Genetic studies of retinoblastoma have yielded unique insights into familial cancer syndromes and the mechanisms of oncogenesis by tumour suppressor genes such as the RB1 gene. In this view, we will summarize past research into the genetics of retinoblastoma that led to the discovery of the RB1 gene and discuss the influence these results have had on the field of cancer research. In addition, we will discuss current research into RB1 as it relates to cancer and its potential for new therapies.
Schubert
E L
EL
Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Hansen
M F
MF
Strong
L C
LC
D000818:Animals; D005134:Eye Neoplasms / Q000175:diagnosis / Q000235:genetics; D016161:Genes, Retinoblastoma / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D011379:Prognosis; D012175:Retinoblastoma / Q000175:diagnosis / Q000235:genetics; D016160:Retinoblastoma Protein / Q000502:physiology
D005819:Genetic Markers; D016160:Retinoblastoma Protein