Risk of secondary cutaneous malignancies in patients with long-standing mycosis fungoides.
BACKGROUND
Patients with mycosis fungoides (MF) are frequently treated with UV light and psoralen (PUVA), nitrogen mustard, and electron beam irradiation, modalities known to predispose persons to development of cutaneous malignancies.


OBJECTIVE
We assessed the relation between these therapeutic modalities and the development of secondary cutaneous malignancies.


METHODS
We reviewed the charts of all patients observed during the past year.


RESULTS
We found that 7 of 71 patients had cutaneous neoplasms in an average follow-up time of 8.3 years. Orthovoltage radiation was used in five of seven cases and PUVA in four of seven. Five of seven patients had multiple neoplasms.


CONCLUSIONS
The risk of the development of second malignancies from the treatment of MF is relatively small and appears to be related to the type of therapy.
Smoller
B R
BR
Department of Pathology, Stanford University Medical Center, CA 94305.
Marcus
R
R
D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000209:etiology; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D011701:PUVA Therapy / Q000009:adverse effects; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D013997:Time Factors
D008466:Mechlorethamine