HLA DPB1 genotyping in Australian aborigines by amplified fragment length polymorphism analysis.
The HLA-DPB1 alleles in 93 Australian aborigines, from two geographically separate areas within Australia, were studied by AFLP analysis. There was a restricted range of DPB1 alleles seen in the aboriginal population, and the distribution of alleles varied between the two aboriginal groups. DPB1*0501 was the most common allele in the aborigines from the Central Desert, whereas DPB1*0401 was the most frequent allele in the Northern Coast aborigines. A new AFLP pattern was observed, and was found to correspond to the allele DPB1*2201, recently identified by SSO analysis. The DPB1 allele frequency distribution for both of the aboriginal groups was different from that seen for the Australian Caucasoid population.
Lienert
K
K
Transplantation Immunology Laboratory, Queen Elizabeth Hospital, Woodville, Australia.
Krishnan
R
R
Fowler
C
C
Russ
G
G
D000483:Alleles; D005787:Gene Frequency; D005802:Genes, MHC Class II; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D015876:Northern Territory; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011793:Queensland; D014904:Western Australia; D044465:White People / Q000235:genetics; D000095283:Australian Aboriginal and Torres Strait Islander Peoples
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen