[Effect of vaporizing high doses of ipratropium bromide on lung ventilation in patients with chronic obstructive pulmonary disease and bronchial asthma].
Authors compared efficacy of high Atrovent doses and Salbutamol on pulmonary ventilation. Examinations were performed in 20 patients with BA and 20 patients with COPD. Each drug was given on separate days in increasing doses (0.04; 0.25 and 0.5 mg) of Atrovent and 0.2 mg of Salbutamol. Bronchodilatation was assessed by measurement of FEV1; FEF25%, FEF50%, FEF75%. Maximal effect in patients with COPD was reached with doses of 0.25 and 0.5 mg of Atrovent (delta FEV1(%) +22). Salbutamol and 0.04 mg of Atrovent were significantly less effective. In patients with BA Salbutamol (delta FEV1(%) +49) are likely to be more effective bronchodilator an Atrovent (delta FEV1(%) +26).
Dor
A
A
Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM we Wrocławiu.
Krasnowska
M
M
Małolepszy
J
J
D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005540:Forced Expiratory Flow Rates / Q000187:drug effects; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D016896:Treatment Outcome
D009241:Ipratropium; D000420:Albuterol
Wpływ nebulizacji duzych dawek bromku ipratropium na wentylacje płuc u chorych na przewlekła obturacyjna chorobe płuc i astme oskrzelowa.