title: Rotavirus vaccine development for the prevention of severe diarrhea in infants and young children.
abstract: Rotaviruses were first detected 20 years ago and emerged rapidly as the single most important recognized etiological agents of severe diarrhea among infants and children under 2 years in both developed and developing countries. They are estimated to cause over 870,000 deaths annually in developing countries. This review highlights recent approaches to the development of a rotavirus vaccine.
authors.affiliation: Epidemiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: A Z
authors.initials: AZ
authors.lastname: Kapikian
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D007116:Immunization, Passive; D007223:Infant; D007224:Infant Care; D012401:Rotavirus / Q000145:classification / Q000276:immunology* / Q000648:ultrastructure; D012400:Rotavirus Infections / Q000517:prevention & control*; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines