title: Hepatic metastases and cavernous hemangiomas: distinction with standard- and triple-dose gadoteridol-enhanced MR imaging.
abstract: OBJECTIVE
  To determine if hepatic metastases can be distinguished from cavernous hemangiomas by pattern analysis of magnetic resonance (MR) images obtained prior to and following administration of gadoteridol at standard (0.1 mmol/kg) and triple (0.3 mmol/kg) doses.
  
  
  METHODS
  Ninety-five patients with proved hepatic metastases (n = 71) or cavernous hemangiomas (n = 24) underwent MR imaging at 16 different institutions. T2-weighted spin-echo and T1-weighted images were obtained before and after gadoteridol administration. Two independent blinded reviewers rated individual features of benignancy versus malignancy on a five-point confidence scale.
  
  
  RESULTS
  The most useful diagnostic features, with 100% specificity, were nodular enhancement for hemangiomas and rim enhancement for metastases. Confident (definitely benign or definitely malignant) diagnoses were rendered in 80 of 95 cases (84%), with an accuracy of a confident diagnosis of 96%.
  
  
  CONCLUSIONS
  The pattern of enhancement on T1-weighted images is highly accurate for distinction between hemangiomas and metastases in images obtained with both doses.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital and Jefferson Medical College, Philadelphia, PA 19107.
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: S
authors.initials: S
authors.lastname: Saini
authors.forename: J
authors.initials: J
authors.lastname: Weinreb
authors.forename: E E
authors.initials: EE
authors.lastname: De Lange
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: J E
authors.initials: JE
authors.lastname: Kuhlman
authors.forename: Y
authors.initials: Y
authors.lastname: Parisky
authors.forename: C D
authors.initials: CD
authors.lastname: Johnson
authors.forename: J J
authors.initials: JJ
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Schnall
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D006392:Hemangioma, Cavernous / Q000175:diagnosis* / Q000453:epidemiology; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium