[The virus-inhibiting activity of a preparation obtained from a mussel hydrolysate].
Antiviral properties were found with a preparation obtained from mussel meat by acid hydrolysis. In the experiments in vitro this mussel hydrolysate reduced the infectious activity of influenza viruses in neutralization tests by 3-6 log. Applications of the preparation to mice infected with a toxigenic influenza virus strain protected from death 66-84% of the animals, the survival rate in controls being from 9 to 16%. The protective effect of mussel hydrolysate was observed both after intranasal and oral administrations. The optimal protective effect was obtained when the preparation was used 5-24 hours before inoculation.
Bichurina
M A
MA
Nikitina
L E
LE
Sovetova
M G
MG
Rekhina
N I
NI
Besedina
T V
TV
Boĭkov
Iu A
IuA
Noskov
F S
FS
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D049872:Bivalvia; D002478:Cells, Cultured; D002642:Chick Embryo; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D008460:Meat; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000401:mortality; D011492:Protein Hydrolysates / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
D000998:Antiviral Agents; D011492:Protein Hydrolysates
Virusingibiruiushchaia aktivnost' preparata, poluchennogo iz midiĭnogo gidrolizata.