Parasite enzymes and the control of roundworm and fluke infestation in domestic animals.
The potential application of parasite enzymes to the serodiagnosis and control of veterinary helminthiases is reviewed. Consideration is given to the use of secreted enzymes as potential antihelminth vaccine components, in the search for novel anthelmintic agents and as serodiagnostic targets. The discussion focuses on recent advances in the definition of the molecular and functional properties of helminth enzymes and the application of this information to the development of novel anthelmintics as well as vaccines. Enzymes included are acetylcholinesterases, enzymes of polyamine and carbohydrate metabolism, proteases and detoxifying activities such as superoxide dismutases and glutathione S-transferases.
Knox
D P
DP
Moredun Research Institute, Edinburgh, Scotland.
D000818:Animals; D000829:Animals, Domestic / Q000469:parasitology*; D000871:Anthelmintics / Q000627:therapeutic use; D000947:Antigens, Helminth / Q000276:immunology; D010450:Endopeptidases / Q000276:immunology / Q000378:metabolism; D006790:Host-Parasite Interactions; D009348:Nematoda / Q000201:enzymology* / Q000276:immunology; D009349:Nematode Infections / Q000175:diagnosis / Q000517:prevention & control / Q000662:veterinary*; D014200:Trematoda / Q000201:enzymology* / Q000276:immunology; D014201:Trematode Infections / Q000175:diagnosis / Q000517:prevention & control / Q000662:veterinary*
D000871:Anthelmintics; D000947:Antigens, Helminth; D010450:Endopeptidases