Toxicity of combined radiation and chemotherapy in non-small cell lung cancer.
The present paper reviews the different acute and late effects due to radiation and chemotherapy on the different organs lying within the chest (lung, esophagus, spinal cord, heart and skin) using available experimental and clinical data. Some specific issues are stressed, such as the problem of time interval between drug and radiation, the latency period for late effects, and the necessity to use an actuarial method to evaluate the real risk of late effects.
Van Houtte
P
P
Department of Radiotherapy, Institut Jules Bordet, Brussels, Belgium.
Danhier
S
S
Mornex
F
F
D000206:Actuarial Analysis; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D009202:Cardiomyopathies / Q000453:epidemiology / Q000209:etiology; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy / Q000009:adverse effects; D004941:Esophagitis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D015337:Multicenter Studies as Topic; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology; D013118:Spinal Cord Diseases / Q000453:epidemiology / Q000209:etiology
D000970:Antineoplastic Agents