Microvascular anastomoses utilizing new intravascular stents.
Evolving microsurgical technique has allowed for the anastomosis of smaller diameter vessels. Standard suture anastomoses cause a measure of stenosis and intimal damage during application and therefore cannot be dependably used in the anastomosis of very small vessels. We developed and tested a fibrin glue-based anastomosis applied over a meltable stent made of mono- di- and tri-glycerides. In vivo rodent studies using the 0.35 mm diameter inferior epigastric artery have shown immediate and short-term patency rates better than those associated with suture technique. The stent technique is significantly faster and easier than the suture technique. The glyceride stent method suffers from decreased late patency due to aneurysm formation. In addition, we developed a glyceride-coated polyethylene glycol-based stent for use in lasered anastomoses. Work on both projects is ongoing.
Moskovitz
M J
MJ
Department of General Surgery, Maimonides Medical Center, Brooklyn, NY.
Bass
L
L
Zhang
L
L
Siebert
J W
JW
D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D005989:Glycerides; D008297:Male; D008833:Microcirculation / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015607:Stents; D014654:Vascular Patency
D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D005989:Glycerides