title: Effects of human immunodeficiency virus and immune status on magnetic resonance imaging of the brain in hemophilic subjects: results from the hemophilia growth and development study.
abstract: To determine the effects of hemophilia and human immunodeficiency virus (HIV) infection on the nervous system, the authors examined the relationship of brain magnetic resonance imaging (MRI) findings to immunologic function and neurologic examination findings. Baseline examinations included physical and neurologic examination, immunologic and virologic testing, and MRI of the brain. On neurologic examination, muscle atrophy was considered to be related to hemophilia if adjacent joints had arthropathy due to bleeding. Muscle atrophy was considered non-hemophilia-related if unrelated to arthropathy or if muscle atrophy was diffuse. Subjects were boys aged 6 to 19 years, enrolled in a multicenter study of the effects of hemophilia and HIV infection on growth and development, all with congenital coagulopathies requiring factor infusions. Three hundred ten subjects had complete data including neurologic examination, T-cell subsets, HIV antibodies, and MRI. Subjects with HIV infection whose CD4+ counts were < 200/microL were compared with subjects with HIV infection and CD4+ counts > or = 200/microL and with HIV-negative subjects, all of whom had CD4+ counts > 200/microL. MRI studies were normal in 230. Abnormal MRI studies were more frequent in HIV-positive subjects with CD4+ counts < 200 (29.4% abnormal compared with 17% in HIV-positive subjects with CD4+ counts > or = 200 and 15.3% in HIV-negative subjects). Diffuse atrophy accounted for most of the excess abnormalities in HIV-positive subjects with CD4+ counts < 200 (77.3% of abnormal scans). Diffuse atrophy on MRI was associated with decreased muscle bulk on neurologic examination, but not with abnormal tendon reflexes.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neurology, University of Southern California School of Medicine.
authors.forename: W G
authors.initials: WG
authors.lastname: Mitchell
authors.forename: M D
authors.initials: MD
authors.lastname: Nelson
authors.forename: C F
authors.initials: CF
authors.lastname: Contant
authors.forename: J F
authors.initials: JF
authors.lastname: Bale
authors.forename: D A
authors.initials: DA
authors.lastname: Wilson
authors.forename: T P
authors.initials: TP
authors.lastname: Bohan
authors.forename: M J
authors.initials: MJ
authors.lastname: Fenstermacher
mesh_terms: D000293:Adolescent; D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications / Q000276:immunology / Q000473:pathology; D001921:Brain / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes; D016022:Case-Control Studies; D002648:Child; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology / Q000473:pathology*; D015497:HIV-1 / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications / Q000276:immunology / Q000473:pathology*; D002836:Hemophilia B / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male