The influence of beta-adrenoceptor and muscarinic receptor agonists and antagonists on the static urethral closure function in healthy females.
The effects of terbutaline, propranolol, carbachol, and atropine on the static urethral closure function were investigated in 20 healthy women. Terbutaline caused a statistically reduction of the urethral pressure in the high pressure zone, but not at the bladder neck or in the distal urethra. The other drugs caused no significant pressure changes. None of the drugs used produced significant changes in the static viscoelastic properties, elastance, and hysteresis of the resting urethra. It is suggested that terbutaline partly reduces intraurethral pressure by reducing muscular tone in the rhabdosphincter and pelvic floor.
Thind
P
P
Department of Urology, Rigshospitalet, University of Copenhagen, Denmark.
Lose
G
G
Colstrup
H
H
Andersson
K E
KE
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004548:Elasticity; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009116:Muscarine / Q000037:antagonists & inhibitors*; D010277:Parasympathomimetics / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013726:Terbutaline / Q000494:pharmacology; D014521:Urethra / Q000294:innervation*; D014563:Urodynamics / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D010277:Parasympathomimetics; D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D001285:Atropine; D009116:Muscarine; D002217:Carbachol; D011433:Propranolol; D013726:Terbutaline