title: Eosinophil cationic protein in the sera of patients with Mycoplasma pneumonia.
abstract: In 1985 we reported that eosinophilia was found in many children with Mycoplasma pneumonia. We measured the serum concentrations of eosinophil cationic protein (ECP) produced by eosinophils in 25 children with Mycoplasma pneumonia, 25 with asthma and 11 with no disease (normal controls). The mean concentrations (+/- SD) of serum ECP in children with Mycoplasma pneumonia, with asthma and the normal controls were 18.7 +/- 12.6, 23.7 +/- 12.2 and 6.5 +/- 1.4 micrograms/ml, respectively. When compared with those of normal controls, these higher serum concentrations of ECP in children with Mycoplasma pneumonia and asthma were statistically significant (P < 0.001). The data were directly correlated with the presence of eosinophilia (r = 0.349). There was no relationship between the amount of ECP and the age of children with Mycoplasma pneumonia. These results suggest that ECP may work as a factor causing a persistent cough similar to asthma in children with Mycoplasma pneumonia.
authors.affiliation: Department of Pediatrics, Kitasato Institute Hospital, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Kitahara
authors.forename: T
authors.initials: T
authors.lastname: Kanemitsu
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001798:Blood Proteins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D047091:Eosinophil Granule Proteins; D006801:Humans; D011019:Pneumonia, Mycoplasma / Q000097:blood*; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases