Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of young and old mice.
The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.
Dozmorov
I M
IM
Department of Immunology, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Kuzin
I I
II
Lutsan
N I
NI
Lutsenko
G V
GV
Prokhorova
A L
AL
Sapozhnikov
A M
AM
Andronova
T M
TM
Ivanov
V T
VT
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000375:Aging / Q000276:immunology*; D000818:Animals; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007107:Immune System / Q000166:cytology / Q000187:drug effects*; D007375:Interleukin-1 / Q000096:biosynthesis; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine