The intriguing link between modulation of both multidrug resistance and ligand-toxin conjugate cytotoxicity.
Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand-toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.
Jaffrézou
J P
JP
Department of Medicine, Stanford University Medical Center, CA 94305-5306.
Laurent
G
G
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects*; D004351:Drug Resistance / Q000235:genetics / Q000502:physiology*; D000922:Immunotoxins / Q000633:toxicity; D008024:Ligands; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010641:Phenotype; D014118:Toxins, Biological / Q000633:toxicity*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D000922:Immunotoxins; D008024:Ligands; D008562:Membrane Glycoproteins; D014118:Toxins, Biological