title: Long-term prognosis of symptomatic lacunar infarcts. A hospital-based study.
abstract: OBJECTIVE
  This study concerns the long-term prognosis of lacunar infarcts.
  
  
  METHODS
  We report the analysis of our hospital-based series of 178 patients consecutively admitted for a lacunar syndrome due to a lacunar infarct diagnosed with computed tomography and magnetic resonance imaging. Demographic data, medical history, vascular risk factors, and imaging data were recorded for each patient. The follow-up was 35 +/- 22 months.
  
  
  RESULTS
  The lacunar syndrome was pure motor hemiparesis in 69 patients (39%), ataxic hemiparesis in 45 patients (25.4%), pure sensory stroke in 15 patients (8.5%), sensorimotor stroke in 14 patients (7.9%), and miscellaneous syndrome in 34 patients (19.2%). The 4-year survival rate was 80 +/- 4% and the 4-year survival rate without recurrent stroke was 85 +/- 3.5%. Using Cox proportional-hazards analysis, the predictors of death were age (P < .02), diabetes mellitus (P < .05), and cigarette smoking (P < .05). We did not find any predictors of recurrence. After 1 year, 74% of the patients had mild or no disability. Using logistic regression analysis, the predictive factors of disability were age more than 70 years (P < .01), diabetes (P < .01), history of stroke or transient ischemic attack (P < .05), and type of lacunar syndrome (P < .01). Imaging data, number of lacunes, and presence of leukoaraiosis were not predictors of outcome.
  
  
  CONCLUSIONS
  Our study suggests that with a high survival rate, a low recurrence rate, and a relatively good functional recovery, lacunar infarcts have a relatively favorable prognosis.
authors.affiliation: Stroke Unit, Clinique Neurologique, Department of Clinical and Biological Neurosciences, Grenoble, France.
authors.forename: I
authors.initials: I
authors.lastname: Clavier
authors.forename: M
authors.initials: M
authors.lastname: Hommel
authors.forename: G
authors.initials: G
authors.lastname: Besson
authors.forename: B
authors.initials: B
authors.lastname: Noèlle
authors.forename: J E
authors.initials: JE
authors.lastname: Perret
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D006332:Cardiomegaly / Q000150:complications / Q000503:physiopathology; D002544:Cerebral Infarction / Q000503:physiopathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006429:Hemiplegia / Q000503:physiopathology; D006760:Hospitalization; D006801:Humans; D008297:Male; D011379:Prognosis; D012008:Recurrence; D012678:Sensation Disorders / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology; D015996:Survival Rate; D013997:Time Factors