Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta.
OBJECTIVE
To determine whether myeloid proliferation was monoclonal or polyclonal in a woman with chronic neutrophilic leukaemia and myeloma.


METHODS
The X-linked probe, M27 beta was used to determine the clonality of the neutrophil population by analysis of restriction fragment length polymorphisms and X inactivation pattern.


RESULTS
A polyclonal pattern of X inactivation was obtained for the neutrophil population in this patient.


CONCLUSIONS
The myeloid expansion in chronic neutrophilic leukaemia associated with myeloma represents a polyclonal reactive response to the plasma cell clone rather than a co-existent myeloproliferative disorder.
Standen
G R
GR
Department of Haematology, Bristol Royal Infirmary.
Steers
F J
FJ
Jones
L
L
D000368:Aged; D015139:Blotting, Southern; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000209:etiology* / Q000235:genetics; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D015342:DNA Probes