title: Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila.
abstract: Viable aristaless (al) mutations of Drosophila affect pattern elements at both ends of the proximodistal axis in a subset of adult appendages. The al gene has been cloned and identified by P-element-mediated germ-line transformation with a genomic DNA fragment, which rescues a lethal mutation of al as well as aspects of the adult al phenotype. The al gene contains a prd-type homeo domain and a Pro/Gln-rich domain and, hence, probably encodes a transcription factor. Its transcript distribution in third-instar imaginal discs closely corresponds to the anlagen of the tissues that later become visibly affected in adult al mutants. The striking similarity of a bimodal al expression in different imaginal discs indicates that al is under the control of a "prepattern," which is shared at least among antennal, leg, and wing discs. The al gene is also transcribed during embryogenesis. Apart from a function in the ontogeny of specific larval head and tail organs, its embryonic transcript pattern suggests a possible role in early imaginal disc development.
authors.affiliation: Institute for Molecular Biology II, University of Zürich, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Schneitz
authors.forename: P
authors.initials: P
authors.lastname: Spielmann
authors.forename: M
authors.initials: M
authors.lastname: Noll
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D029721:Drosophila Proteins; D005801:Genes, Homeobox; D005804:Genes, Lethal; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins; D011506:Proteins; C079410:al protein, Drosophila; D004247:DNA