title: Sequential manifestation of different forms of early-onset periodontitis. A case report.
abstract: Pathogenic bacteria constitute the primary extrinsic agent in the etiology of early onset periodontitis. However, the risk of developing periodontal disease is not equal for all individuals, suggesting host factors are involved in determining an individual's disease susceptibility. In this report, a case of an otherwise healthy female, who exhibited prepubertal periodontitis (PPP) at age 10, juvenile periodontitis (JP) at age 13, and rapidly progressive periodontitis (RPP) at age 29 years, is presented. Microbial, immunological, and genetic features of the case are presented. PPP, JP, and RPP are considered distinct disease entities, albeit with similar pathology and pathogenesis, yet all were manifest sequentially in the same individual. This report presents the idea that certain individuals are predisposed to early-onset periodontal diseases and the early identification of risk factors is important in the management of these individuals.
authors.affiliation: Department of Periodontics, Hebrew University, Hadassah School of Medicine, Jerusalem, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Shapira
authors.forename: A
authors.initials: A
authors.lastname: Smidt
authors.forename: T E
authors.initials: TE
authors.lastname: Van Dyke
authors.forename: V
authors.initials: V
authors.lastname: Barak
authors.forename: A W
authors.initials: AW
authors.lastname: Soskolne
authors.forename: C
authors.initials: C
authors.lastname: Brautbar
authors.forename: M N
authors.initials: MN
authors.lastname: Sela
authors.forename: E
authors.initials: E
authors.lastname: Bimstein
mesh_terms: D000293:Adolescent; D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000302:isolation & purification; D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D001439:Bacteroides / Q000302:isolation & purification; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D009000:Monocytes / Q000276:immunology; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D006680:HLA Antigens