title: Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined immunodeficiency mouse model.
abstract: The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56 degrees C but lower than 72 degrees C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100 degrees C was necessary to completely inactivate HPV type 11 genome expression.
authors.affiliation: Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.
authors.forename: W
authors.initials: W
authors.lastname: Bonnez
authors.forename: R C
authors.initials: RC
authors.lastname: Rose
authors.forename: C
authors.initials: C
authors.lastname: Borkhuis
authors.forename: C
authors.initials: C
authors.lastname: Da Rin
authors.forename: R C
authors.initials: RC
authors.lastname: Reichman
mesh_terms: D000818:Animals; D001483:Base Sequence; D003218:Condylomata Acuminata / Q000821:virology*; D015344:DNA Probes, HPV; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000145:classification / Q000502:physiology*; D010412:Penile Neoplasms / Q000821:virology*; D016511:Severe Combined Immunodeficiency / Q000821:virology; D012867:Skin / Q000821:virology; D016038:Skin Transplantation; D013370:Subrenal Capsule Assay; D013696:Temperature; D014183:Transplantation, Heterologous
chemical_list: D015344:DNA Probes, HPV