Radiation induction of immediate early genes: effectors of the radiation-stress response.
Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NF kappa B are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy.
Weichselbaum
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RR
University of Chicago, Department of Radiation and Cellular Oncology, IL.
Hallahan
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D
Fuks
Z
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Kufe
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D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation / Q000528:radiation effects*; D005809:Genes, Regulator / Q000502:physiology* / Q000528:radiation effects*; D008969:Molecular Sequence Data; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000633:toxicity; D015398:Signal Transduction / Q000502:physiology / Q000528:radiation effects; D013312:Stress, Physiological / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics*; D014158:Transcription, Genetic / Q000502:physiology / Q000528:radiation effects
D017382:Reactive Oxygen Species