Low doses of natural human interferon alpha inhibit the development of Babesia microti infection in BALB/c mice.
Studies were undertaken to determine whether treatments with low doses of natural human interferon alpha (HuIFN-alpha) administered by various routes could inhibit the development of the intra-erythrocytic protozoan Babesia microti in BALB/c mice. HuIFN-alpha treatment given intramuscularly significantly inhibited development of the parasitaemia of the parasite compared with infections in control mice.
Orinda
G O
GO
Department of Parasitology, University of Queensland, St. Lucia, Australia.
Waltisbuhl
D J
DJ
Young
A S
AS
Wright
I G
IG
D000284:Administration, Oral; D000818:Animals; D001404:Babesiosis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000662:veterinary; D007274:Injections, Intraperitoneal / Q000662:veterinary; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation
D016898:Interferon-alpha