title: Effects of aluminum (III) and fluoride on the demineralization of bovine enamel: a longitudinal microradiographic study.
abstract: Longitudinal microradiography has been used to determine inhibiting effects of aluminum (III), Al, and fluoride on mineral loss from slices of bovine enamel exposed to a demineralizing solution 4 h daily for 35 days. Inhibitor treatment was 5 min four times daily. For the remaining time, the samples were immersed in a neutral calcium phosphate solution which allowed neither remineralization nor demineralization. This study indicates that a 1-mM (27 ppm) solution of Al in a 0.1-M lactate solution, pH 5, has an inhibitory effect on the in vitro demineralization of bovine enamel. Application of this solution alternating with 20 mM (380 ppm) fluoride gave the same total inhibition as treatment with 20 mM fluoride alone.
authors.affiliation: Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen.
authors.forename: M
authors.initials: M
authors.lastname: Höök
authors.forename: J
authors.initials: J
authors.lastname: Christoffersen
authors.forename: M R
authors.initials: MR
authors.lastname: Christoffersen
authors.forename: E S
authors.initials: ES
authors.lastname: Leonardsen
authors.forename: M R
authors.initials: MR
authors.lastname: Rassing
authors.forename: E
authors.initials: E
authors.lastname: Rostrup
mesh_terms: D000534:Alum Compounds / Q000008:administration & dosage / Q000494:pharmacology; D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D003743:Dental Enamel / Q000187:drug effects*; D017886:Durapatite / Q000737:chemistry; D005459:Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D007773:Lactates / Q000009:adverse effects; D008137:Longitudinal Studies; D008852:Microradiography; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology; D017001:Tooth Demineralization / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control
chemical_list: D000534:Alum Compounds; D007773:Lactates; C041524:aluminum sulfate; D012969:Sodium Fluoride; D017886:Durapatite; D000535:Aluminum; D005459:Fluorides