title: 7-OH-DPAT antagonizes dopamine D2 receptor-inhibited adenylyl cyclase activity.
abstract: (+/-)7-OH-DPAT (7-hydroxy-2-(di-n-propylamino) tetralin) binds to both dopamine D2 and D3 receptor subtypes. In 7315c pituitary tumor cell membranes, which express only the D2 type of dopamine receptor, dopamine inhibited, and 7-OH-DPAT had no effect on adenylyl cyclase activity. When combined, 7-OH-DPAT antagonized the inhibition of adenylyl cyclase produced by dopamine. Thus, it appears that 7-OH-DPAT acts as an antagonist at dopamine D2 receptors.
authors.affiliation: Psychobiology Section, NIDA Intramural Research Program, Baltimore, MD 21224.
authors.forename: S
authors.initials: S
authors.lastname: Izenwasser
authors.forename: J L
authors.initials: JL
authors.lastname: Katz
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D001667:Binding, Competitive; D005576:Colforsin / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology*; D013469:Sulpiride; D013764:Tetrahydronaphthalenes / Q000378:metabolism / Q000494:pharmacology*; D014316:Tritium
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D013764:Tetrahydronaphthalenes; D014316:Tritium; D005576:Colforsin; D013469:Sulpiride; D000262:Adenylyl Cyclases; C031349:7-hydroxy-2-N,N-dipropylaminotetralin; D004298:Dopamine