Psoriatic arthritis: a clinical, radiological and genetic study of 58 Italian patients.
It is well known that genetic heterogeneity and/or the complex interaction of several MCH-linked risk factors can explain the onset and the broad spectrum of Psoriatic Arthritis (PsA) from the clinical point of view. Fifty-eight patients with PsA (Moll and Wright criteria), 35 men and 23 women, mean age of 45, 14, were studied; all the patients were assessed by both clinical and radiological examination, with particular attention to the sacroiliac joints. HLA typing of the patients confirmed the association between PsA and HLA-B39 (p = 0.0008) and Cw6 (p = 0.0011). In addition a significant increase in DQ2 antigen (p = 0.004) has been found. No correlation of any particular HLA antigen with clinical subsets (oligo-polyarticular peripheral PsA, axial PsA and axial with peripheral PsA) or erosive incidence of joint involvement-generally related to the duration of the disease--was found.
Trabace
S
S
Department of Experimental Medicine, La Sapienza University, Rome, Italy.
Cappellacci
S
S
Ciccarone
P
P
Liaskos
S
S
Polito
R
R
Zorzin
L
L
D000328:Adult; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography
D006680:HLA Antigens