Anti-HIV agents. III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines.
The one-pot synthesis of 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines is described. The antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained was explored: 1-(2',6'-dichlorophenyl) (5g) and 1-(2',6'-difluorophenyl)-1H,3H-thiazolo- [3,4-a]imidazo[4,5-b]pyridine (5h) exhibit reproducible in vitro anti-HIV activity.
Chimirri
A
A
Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Grasso
S
S
Montforte
A M
AM
Monforte
P
P
Zappalà
M
M
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D006678:HIV / Q000187:drug effects*; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000998:Antiviral Agents; D011725:Pyridines; D013844:Thiazoles