title: Mitral valve prolapse in persons with Down syndrome.
abstract: This study was designed to determine the prevalence of mitral valve prolapse and aortic insufficiency in home-reared, young persons with Down syndrome. Of the 36 individuals (ages 20-32 years) enrolled in this study, 20 had abnormal echocardiographic findings. Thirteen patients had mitral valve prolapse, 3 had both mitral valve prolapse and aortic insufficiency, 2 had only aortic insufficiency, and 2 had other mitral valve disorders. In 14 of the 16 patients with mitral valve prolapse, a midsystolic click was heard. Theories of the pathogenesis and possible complications of mitral valve prolapse and its relationship to exercise and sport activities are discussed.
authors.affiliation: Rhode Island Hospital.
authors.forename: S M
authors.initials: SM
authors.lastname: Pueschel
authors.forename: J C
authors.initials: JC
authors.lastname: Werner
mesh_terms: D000328:Adult; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008945:Mitral Valve Prolapse / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D012237:Rhode Island / Q000453:epidemiology; D013177:Sports / Q000502:physiology