title: A lipoprotein signal peptide encoded by the staphylococcal conjugative plasmid pSK41 exhibits an activity resembling that of Enterococcus faecalis pheromone cAD1.
abstract: The traH gene of the staphylococcal conjugative plasmid pSK41 has recently been shown to encode a lipoprotein (N. Firth, K. P. Ridgway, M. E. Byrne, P. D. Fink, L. Johnson, I. T. Paulsen, and R. A. Skurray, Gene 136:13-25, 1993). Here we report that traH encodes a product recognized as a pheromone by Enterococcus faecalis cells harboring the conjugative plasmid pAD1. The mature traH product is not essential for this phenomenon, as expression of pheromone-like activity was found to require sequences encoding only the pro-TraH signal peptide.
authors.affiliation: School of Biological Sciences, University of Sydney, New South Wales, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Firth
authors.forename: P D
authors.initials: PD
authors.lastname: Fink
authors.forename: L
authors.initials: L
authors.lastname: Johnson
authors.forename: R A
authors.initials: RA
authors.lastname: Skurray
mesh_terms: D000595:Amino Acid Sequence; D001422:Bacterial Adhesion; D001426:Bacterial Proteins; D001483:Base Sequence; D003227:Conjugation, Genetic / Q000235:genetics; D013293:Enterococcus faecalis / Q000737:chemistry; D008074:Lipoproteins / Q000235:genetics; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism*; D010675:Pheromones / Q000378:metabolism*; D010957:Plasmids / Q000235:genetics*; D021382:Protein Sorting Signals / Q000235:genetics*; D013211:Staphylococcus aureus / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins; D009687:Nuclear Proteins; D009842:Oligopeptides; D010675:Pheromones; D021382:Protein Sorting Signals; C065598:TraH protein, Bacteria; C043691:cAD1 bacterial sex hormone