title: Epilepsy in congenital lipodystrophy. Case report.
abstract: A case of congenital lipodystrophy complicated by complex-partial epilepsy is reported in a nine-year-old girl. The peculiarity of this rare case is represented by partial complex epilepsy with diffuse electroencephalographic alterations represented by a continuous seizure-like pattern that persisted unmodified despite the successful antiepileptic treatment. Although the etiopathology of lipodystrophy is, at present, still elusive, we hypothesize that the primitive dysfunction of lipidic metabolism plays a critical role in both determining central nervous system (CNS) alterations and the findings that characterized this extremely rare disease.
authors.affiliation: Institute of Neurology, School of Medicine, University of Cagliari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Marrosu
authors.forename: C
authors.initials: C
authors.lastname: Ottelio
authors.forename: M G
authors.initials: MG
authors.lastname: Rachele
authors.forename: M
authors.initials: M
authors.lastname: Giagheddu
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology; D002220:Carbamazepine / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D004576:Electromyography; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000151:congenital / Q000175:diagnosis / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology
chemical_list: D002220:Carbamazepine