title: [Acute-phase reaction and parasitism in the central adrenal vein in Chagas' disease patients].
abstract: The systemic reaction to severe trauma and/or infection, acute phase response (APR), are often associated with immunosuppression and reactivation of chronic latent infection. Our main purpose was to verify, in a group of 71 autopsied chronic chagasic with or without APR, the frequency of T. cruzi nests in the central vein of adrenal gland (CVAG). APR, defined by: 1) death secondary to sepsis and/or trauma plus, 2) bleeding stress gastric ulcerations or 3) spleen reactional state or 4) liver steatosis, was observed in 30 chronic chagasic (APR+). Weight, height and body mass index (BMI) were obtained. APR(+) chronic chagasic had worse nutritional status than APR(-) ones: weight = 49.0 vs 54.5 kg; BMI = 17.5 vs 20.6 kg/m2 (median p < 0.05). CVAG T. cruzi nests frequency were similar (43.3% and 43.9%, respectively) between both Groups. We conclude that APR(+) chronic chagasic had worse nutritional status than APR(-) ones, and that APR development did not change the CVAG T. cruzi nests frequency.
authors.affiliation: Disciplina de Nutrologia, Faculdade de Medicina do Triângulo Mineiro (FMTM), Uberaba, MG.
authors.forename: D F
authors.initials: DF
authors.lastname: da Cunha
authors.forename: C de O
authors.initials: Cde O
authors.lastname: Vieira
authors.forename: G
authors.initials: G
authors.lastname: de Paula e Silva
authors.forename: G R
authors.initials: GR
authors.lastname: Erédia
authors.forename: V de P
authors.initials: Vde P
authors.lastname: Teixeira
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology* / Q000469:parasitology*; D000311:Adrenal Glands / Q000098:blood supply* / Q000469:parasitology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D014349:Trypanosoma cruzi / Q000302:isolation & purification; D014680:Veins / Q000469:parasitology
vernacular_title: Reação de fase aguda e parasitismo na veia central da supra-renal de chagásicos crônicos.