title: CD27: marker and mediator of T-cell activation?
abstract: CD27 is a lymphocyte-specific member of the tumour necrosis factor receptor (TNF-R) family, expression of which is tightly regulated during T-cell ontogeny. Recently, the ligand for CD27 was identified and was shown to be identical to CD70, a novel member of the TNF family. Functional experiments show that the interaction between CD27 and its ligand generates a co-stimulatory signal for T-cell activation. Here, Rogier Hintzen and colleagues integrate the phenotypic and functional data available on CD27 and its ligand, and propose a role for CD27 in the amplification of T-cell responses.
authors.affiliation: Dept of Clinical (Viro-) Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
authors.forename: R Q
authors.initials: RQ
authors.lastname: Hintzen
authors.forename: R
authors.initials: R
authors.lastname: de Jong
authors.forename: S M
authors.initials: SM
authors.lastname: Lens
authors.forename: R A
authors.initials: RA
authors.lastname: van Lier
mesh_terms: D000818:Animals; D015703:Antigens, CD; D015415:Biomarkers; D053282:CD27 Ligand; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D008565:Membrane Proteins / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D053282:CD27 Ligand; C505771:CD70 protein, human; D008024:Ligands; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7