title: Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism.
abstract: The gene encoding the human G-protein-coupled inwardly rectifying potassium channel designated GIRK1 (gene symbol, KCNJ3) was mapped to chromosome 2 by analyzing its segregation in a panel of human-hamster somatic cell hybrids. This assignment was confirmed by fluorescence in situ hybridization to metaphase chromosomes, and the gene was further localized to band 2q24.1. A highly informative simple tandem repeat DNA polymorphism of the form (CA)n was identified and used to localize KCNJ3 within the genetic map of the long arm of chromosome 2.
authors.affiliation: Howard Hughes Medical Institute, University of Chicago, Illinois 60637.
authors.forename: M
authors.initials: M
authors.lastname: Stoffel
authors.forename: R
authors.initials: R
authors.lastname: Espinosa
authors.forename: K L
authors.initials: KL
authors.lastname: Powell
authors.forename: L H
authors.initials: LH
authors.lastname: Philipson
authors.forename: M M
authors.initials: MM
authors.lastname: Le Beau
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D006224:Cricetinae; D019204:GTP-Binding Proteins; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D011976:Receptors, Muscarinic / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D015221:Potassium Channels; D011976:Receptors, Muscarinic; D019204:GTP-Binding Proteins