Evaluation of a new chelating agent for cadmium: a preliminary report.
The Plasma Mobilizing Index parameters of the newly synthesized chelating agent THP-12-ane N4, determined by computer simulation studies, have indicated that this chelating agent might be a good antagonist for cadmium intoxication. Experiments conducted on rats confirmed this observation and showed that THP-12-ane N4 might have the ability to chelate and mobilize cadmium in vivo.
Gulumian
M
M
Department of Biochemistry, Department of National Health and Population Development, Johannesburg, Republic of South Africa.
Casimiro
E
E
Linder
P W
PW
Rama
D B
DB
Hancock
R D
RD
D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000097:blood* / Q000652:urine; D002614:Chelating Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D003198:Computer Simulation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D007928:Lethal Dose 50; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D011916:Rats, Inbred F344; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D002614:Chelating Agents; D006571:Heterocyclic Compounds; D002104:Cadmium; C082033:N,N',N'',N'''-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane