Is fibromyalgia caused by a glycolysis impairment?
Glycolysis was studied in people with fibromyalgia syndrome (FMS), hypothyroidism (HO), chronic osteoarticular pain (OACP), and normal control subjects. Comparisons between the controls and the three study groups revealed increased pyruvate and increased lactate (L) production in FMS and HO; decreased adenosine triphosphate (ATP) and lactase dehydrogenase (LDH) isoenzymes in FMS only; and no glycolytic impairment in OACP.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005356:Fibromyalgia / Q000209:etiology* / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism; D010146:Pain