Different requirements for membrane fusion mediated by the envelopes of human immunodeficiency virus types 1 and 2.
CD4+ cells derived from the human cell lines U87MG and SCL1 cannot be infected by human immunodeficiency virus type 1 (HIV-1) or fuse with cells expressing the HIV-1 envelope. This block was complemented in heterokaryons with HeLa cells and probably reflects the absence of cellular factors necessary for membrane fusion. Since U87MG cells expressing CD4 are permissive to HIV-2, distinct cellular factors could be required for fusion mediated by two related human retroviruses.
Dragic
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T
Institut National de la Santé et de la Recherche Médicale U332, Institut Cochin de Génétique Moléculaire, Paris, France.
Alizon
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M
D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000382:microbiology*; D002459:Cell Fusion; D002478:Cells, Cultured; D015686:Gene Products, env / Q000378:metabolism*; D015497:HIV-1 / Q000472:pathogenicity*; D015498:HIV-2 / Q000472:pathogenicity*; D006367:HeLa Cells; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D008561:Membrane Fusion; D051379:Mice; D011991:Receptors, Virus / Q000378:metabolism; D014760:Viral Fusion Proteins / Q000502:physiology*
D015704:CD4 Antigens; D015686:Gene Products, env; D011991:Receptors, Virus; D014760:Viral Fusion Proteins