Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma.
We report a case of lipoblastoma in a 17-month-old male patient with a pseudodiploid karyotype of 46,XY,der(14)t(8;14)(q11.2;q24). The tumor cells show two normal chromosome 8 homologs in addition to the extra 8q11.2-->qter segment, making it trisomic for the region 8q11.2-->qter, and monosomic for 14q24-->qter. Reports of chromosome studies in lipoblastoma are rare; however, a breakpoint in the long arm of chromosome 8q11-13 appears to be emerging as a consistent finding.
Sawyer
J R
JR
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Parsons
E A
EA
Crowson
M L
ML
Smith
S
S
Erickson
S
S
Bell
J M
JM
D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D010386:Pelvic Neoplasms / Q000235:genetics* / Q000473:pathology