Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists.
Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non-peptide antagonists have been proposed but they are mostly of low potency and non-selective. Our recent observations that alpha-trinositol (D-myo-inositol 1.2.6-trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non-peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down-regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders.
Edvinsson
L
L
Department of Internal Medicine, University Hospital, Lund, Sweden.
Erlinge
D
D
Sun
X Y
XY
Hedner
T
T
D000818:Animals; D006801:Humans; D007295:Inositol Phosphates / Q000494:pharmacology; D009412:Nerve Fibers / Q000502:physiology; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D017476:Receptors, Neuropeptide Y / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D007295:Inositol Phosphates; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C059368:atrinositol; D009638:Norepinephrine