title: Brain-applied magnetic fields and immune response: role of the pineal gland.
abstract: In an attempt to clarify the mechanisms underlying immunopotentiation induced by prolonged exposure of the rat brain to static magnetic fields, and to evaluate the role of the pineal gland in that phenomenon, experiments were carried out on the following groups of adult rats (maintained under a 12 hr light/12 hr dark photoperiod): pinealectomized rats (Px); rats with micromagnets implanted to the occipito-parietal region of the skull (M); rats pinealectomized and implanted with micromagnets to the skull (PxM); sham-pinealectomized rats with non-magnetic beads implanted to the occipito-parietal area of the skull (ShPxMx); and intact controls (IC). Twenty-one days after surgery, animals of all groups were immunized with sheep red blood cells and tested for plaque forming cell (PFC) response and serum hemagglutinin level. Humoral immune reactions decreased significantly in Px rats, while increased markedly in M rats in comparison to the ShPxMx and IC controls. Compromised immune function induced by pinealectomy was restored by prolonged exposure of the brain to magnetic fields (PxM rats). Thus reconstituted immune responsiveness in PxM rats reached the level observed in controls, but was lower than that in M rats. The results imply that magnetic fields applied to the rat brain may exert their immunoenhancing activity in the absence of the pineal gland. However, this activity of magnetic fields is more pronounced in the presence of the pineal organ. The latter finding suggests the involvement of the pineal in the immunopotentiation induced by magnetic fields, but does not imply that magnetic fields operate solely via the pineal gland.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Immunology Research Center, Belgrade, Yugoslavia.
authors.forename: B D
authors.initials: BD
authors.lastname: Janković
authors.forename: K
authors.initials: K
authors.lastname: Jovanova-Nesić
authors.forename: V
authors.initials: V
authors.lastname: Nikolić
authors.forename: P
authors.initials: P
authors.lastname: Nikolić
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001921:Brain / Q000276:immunology*; D002940:Circadian Rhythm; D004574:Electromagnetic Fields; D006388:Hemagglutinins / Q000097:blood; D008027:Light; D008297:Male; D008550:Melatonin / Q000378:metabolism; D015213:Neuroimmunomodulation; D010870:Pineal Gland / Q000276:immunology* / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006388:Hemagglutinins; D008550:Melatonin