[Pharmacologic analysis of the free radical mechanism of poisoning-induced memory disorders].
Ethylene glycol, the pyrethroid pesticide deltametrin, and the m-cholinolytics atropine and scopolamine disturb the formation and storage of signs of memory in rats appraised in the test for conditional reaction of passive and active avoidance. The antioxidants alpha-tocopherol and sodium selenite, the nootropic agent piracetam, and the amino acid L-tryptophan prevent amnesia. Spectrometry of optic density in a "diphenylpicrylhydrazil-drug" model system showed the existence of anti-radical activity in piracetam and L-tryptophan. It is suggested that the anti-amnestic efficacy of piracetam and L-tryptophan is associated, to a certain measure, with their antioxidant properties.
Gromov
L A
LA
Portniagina
V A
VA
Sereda
P I
PI
Bobkova
L S
LS
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005609:Free Radicals; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D011041:Poisoning / Q000188:drug therapy*; D051381:Rats
D000975:Antioxidants; D005609:Free Radicals
Farmakologicheskiĭ analiz svobodnoradikal'nogo mekhanizma intoksikatsionnykh narusheniĭ pamiati.