Anorexia following the systemic injection of amylin.
The intravenous injection of 100 micrograms/kg of rat amylin reduced food intake in schedule-fed rats for 1 h of an 8 h measurement period. Associated with this brief anorexia was a hyperglycemic response, observed 30 min after a subsequent amylin administration. Determination of neurochemical alterations revealed increased concentration of serotonin in the hypothalamus and decreased level of the dopamine metabolite, 3-methoxytyramine, in the corpus striatum. Since similar neurochemical alterations were observed following the systemic injection of glucose, both the neurochemical changes and anorexia following intravenous amylin treatment may be secondary to hyperglycemia.
Chance
W T
WT
Department of Surgery, University of Cincinnati Medical Center, OH.
Balasubramaniam
A
A
Stallion
A
A
Fischer
J E
JE
D000682:Amyloid / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007275:Injections, Intravenous; D058228:Islet Amyloid Polypeptide; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000682:Amyloid; D001786:Blood Glucose; D058228:Islet Amyloid Polypeptide; D018377:Neurotransmitter Agents; D005947:Glucose