Measles virus-induced changes in leukocyte function antigen 1 expression and leukocyte aggregation: possible role in measles virus pathogenesis.
Measles virus (MV) infection of U937 cell or peripheral blood leukocyte cultures was shown to induce changes in the expression of leukocyte function antigen 1 (LFA-1) and cause marked aggregation of these cells. Addition of selected monoclonal antibodies specific for LFA-1 epitopes that did not neutralize MV in standard neutralization assays were found to block both virus-induced leukocyte aggregation and virus dissemination. These data suggest that MV modulation of LFA-1 expression on leukocytes may be an important step in MV pathogenesis.
Attibele
N
N
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas.
Wyde
P R
PR
Trial
J
J
Smole
S C
SC
Smith
C W
CW
Rossen
R D
RD
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015703:Antigens, CD / Q000096:biosynthesis*; D018821:CD18 Antigens; D002449:Cell Aggregation / Q000187:drug effects; D003470:Culture Media / Q000494:pharmacology; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006801:Humans; D016023:Integrins / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000382:microbiology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000096:biosynthesis*; D008457:Measles / Q000209:etiology*; D008459:Measles virus / Q000502:physiology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018821:CD18 Antigens; D003470:Culture Media; D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1