title: Deconvolution method for assessing the absorption of a drug with reversible metabolic pathways.
abstract: A method has been established to determine the input rate for a drug with reversible metabolic processes. This method is based on linear system properties without imposing a compartment model for describing the disposition of the drug and the metabolite and their interconnections. The solution is a deconvolution method in N-dimensional space. A general solution has been obtained for calculating the parameters needed to describe the input function. The specific solution for a staircase input function (point-area deconvolution) is explicitly derived. Using a staircase input function is not a robust method and can give negative input values when applied to simulated data sets with a large amount of variability. This suggests the need for more robust functional forms to describe the input function.
authors.affiliation: Alza Corporation, Palo Alto, CA 94303.
authors.forename: S
authors.initials: S
authors.lastname: Hwang
authors.forename: M
authors.initials: M
authors.lastname: Knowles
mesh_terms: D000042:Absorption; D000818:Animals; D008432:Mathematical Computing; D008722:Methods; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D051381:Rats; D013454:Sulfoxides / Q000097:blood; D013467:Sulindac / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D004364:Pharmaceutical Preparations; D013454:Sulfoxides; D013467:Sulindac; C025462:sulindac sulfide