Enhancement of migration activity in cholesterol-poor endothelial cells by pre-treating with HMG-CoA reductase inhibitors.
When bovine endothelial cells isolated from carotid arteries were cultured with a low density lipoprotein(LDL)-deficient serum for 2 days, their intracellular free cholesterol levels decreased. Under this condition, exposure of the endothelial cells to simvastatin and pravastatin, HMG-CoA reductase inhibitors used clinically, resulted in further decrease in the free cholesterol levels. The migration activity was enhanced in the cells cultured with the LDL-deficient serum and it was more enhanced in the cells treated with HMG-CoA reductase inhibitors under the LDL-deficient serum condition. These results suggest that cholesterol plays a negative role in wound healing in arterial walls and acts as one of the risk factors for arteriosclerosis.
Ma
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Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
Morita
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Murota
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D000818:Animals; D001769:Blood; D002339:Carotid Arteries; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects*; D002784:Cholesterol / Q000032:analysis / Q000502:physiology*; D003470:Culture Media; D004730:Endothelium, Vascular / Q000737:chemistry / Q000166:cytology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL / Q000502:physiology; D008148:Lovastatin / Q000031:analogs & derivatives / Q000494:pharmacology; D017035:Pravastatin / Q000494:pharmacology; D019821:Simvastatin
D003470:Culture Media; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin; D017035:Pravastatin