Enhanced sensitivity to salt-induced high blood pressure in diabetes mellitus.
Salt-induced high blood pressure in diabetic rats was compared with that in non-diabetic (control) rats. Before the rats had eaten the high-salt diet, the diabetic group exhibited significantly greater pressor response to noradrenaline (100 ng/100 g body weight) than the controls (P < 0.05). When the rats were given a high-salt diet, a significant increase in blood pressure was recorded 4 weeks earlier in the diabetic than in the control group (P < 0.05); this increase occurred after 2 weeks in the diabetic group, but after 6 weeks of high-salt diet in the controls. The enhanced state of vascular reactivity in the diabetic rats was probably responsible for their enhanced sensitivity to salt-induced high blood pressure.
Orie
N N
NN
Department of Physiology, College of Medical Sciences, University of Calabar, Nigeria.
Aloamaka
C P
CP
Iyawe
V I
VI
D000818:Animals; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012982:Sodium, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D014655:Vascular Resistance / Q000187:drug effects
D012982:Sodium, Dietary; D009638:Norepinephrine