The calf superoxide dismutase receptor of rat hepatocytes.
The presence of a specific SOD surface membrane receptor in rat hepatocyte cells was investigated using ligand blot analysis of the SOD receptor with 125I-SOD, and binding studies with iodinated and fluorescinated SOD. A specific SOD receptor with a molecular weight of about 320 kDa was identified. We suggest that the modulatory role of SOD on HMG-CoA reductase is exerted through this specific receptor.
Mondola
P
P
Istituto di Scienze Fisiologiche Umane, Facoltà di Medicina e Chirurgia dell'Università di Napoli Federico II, Italy.
Santillo
M
M
Santangelo
F
F
Garbi
C
C
Daniele
A
A
D000818:Animals; D002417:Cattle; D002460:Cell Line; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D011869:Radioligand Assay; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*
D011956:Receptors, Cell Surface; D013482:Superoxide Dismutase