Bilateral effect of unilateral vasectomy on testicular testosterone biosynthesis.
Twelve immature male dogs underwent a left vasectomy (group A). An additional five underwent a sham operation (group B). Sixteen weeks after the surgery, the bilateral mean values for caudal epididymal sperm content, the percentage of motile spermatozoa, intratesticular testosterone concentration, and testicular secretion of androgen-binding protein (in vitro) were significantly lower in group A. The mean peripheral serum testosterone responses 3 hours after human chorionic gonadotropin stimulation (3,000 IU) were significantly lower in group A than in group B (6.3 ng/mL v 9.5 ng/mL). These findings indicate a bilateral deficiency in both Leydig and Sertoli cell secretory function in unilaterally vasectomized dogs, resulting in impaired bilateral spermatogenesis and sperm maturation. The authors suggest that unilateral injuries of the vas deferens during hernia operations in children may result in bilateral testicular dysfunction.
Antypas
S
S
Department of Urology, Tottori University School of Medicine, Yonago, Japan.
Sofikitis
N
N
Rodriguez
F
F
Zavos
P M
PM
Miyagawa
I
I
D000727:Androgen-Binding Protein / Q000378:metabolism; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004285:Dogs; D005640:Follicle Stimulating Hormone / Q000097:blood; D007985:Leydig Cells / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D012708:Sertoli Cells / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000033:anatomy & histology / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis*; D014659:Vasectomy
D000727:Androgen-Binding Protein; D001323:Autoantibodies; D006063:Chorionic Gonadotropin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone