title: Central catheter infection by Trichosporon beigelii after autologous blood stem cell transplantation. A case report and review of the literature.
abstract: A case of localized Trichosporon beigelii infection is reported in a 40-year-old woman with Ph+ chronic granulocyte leukemia who underwent autologous blood stem cell transplantation. On day +14 after autograft, while severely neutropenic, she developed a local infection involving the soft tissues surrounding the central venous catheter (CVC) point of entry into the subclavian vein. Trichosporon beigelii was isolated from culture of the CVC tip; resolution occurred after removal of the CVC, neutrophil recovery and antifungal treatment with amphotericin B and 5-fluorocytosine. To our knowledge this is the first case of CVC localized infection from Trichosporon beigelii after transplantation.
authors.affiliation: Dipartimento di Ematologia, Ospedale V. Cervello, Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Vasta
authors.forename: M
authors.initials: M
authors.lastname: Menozzi
authors.forename: R
authors.initials: R
authors.lastname: Scimé
authors.forename: A
authors.initials: A
authors.lastname: Indovina
authors.forename: A
authors.initials: A
authors.lastname: Speciale
authors.forename: G
authors.initials: G
authors.lastname: Liberti
authors.forename: C
authors.initials: C
authors.lastname: Spanò
authors.forename: I
authors.initials: I
authors.lastname: Majolino
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001804:Blood Transfusion, Autologous; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy; D015465:Leukemia, Myeloid, Accelerated Phase / Q000150:complications / Q000628:therapy; D009181:Mycoses / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D014250:Trichosporon / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents