Serum enzymes in hypothyroidism.
OBJECTIVE
To report three cases of hypothyroidism detected because of unexplained elevation of serum enzyme levels on biochemical testing.


METHODS
Clinical details and serum enzyme results were obtained before and after L-thyroxine (T4) replacement therapy.


RESULTS
The three patients all had serum creatine kinase (CK) levels > 2000 U/L, aspartate aminotransferase (AST) > 90 U/L, and lactate dehydrogenase (LD) > 300 U/L at presentation, with these levels being 10-15, 2-6, and 2-3 times the upper reference limits respectively. CK isoenzyme determination was consistent with skeletal muscle origin. Thyroid function tests performed after consultation with the clinical biochemist confirmed the biochemical diagnosis of primary hypothyroidism. A rapid fall toward normal serum enzyme levels occurred in response to T4 replacement therapy.


CONCLUSIONS
Although serum enzymes are an integral part of both the liver and cardiac profiles provided by laboratory, they are not organ specific, and changes may reflect dysfunction elsewhere in the body. Elevations of serum CK (and other muscle enzymes) may occur in hypothyroid subjects, the cause of which has not been established. The clinical diagnosis of hypothyroidism requires a high index of suspicion and should be considered in patients with unexplained persistent elevations of serum muscle enzymes.
Burnett
J R
JR
Division of Chemical Pathology, Wellington Hospital.
Crooke
M J
MJ
Delahunt
J W
JW
Feek
C M
CM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000201:enzymology*; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D013974:Thyroxine