title: Antidiarrhoeic activity of quercitrin in mice and rats.
abstract: Quercitrin, a flavonoid isolated from Euphorbia hirta, shows antidiarrhoeic activity at doses of 50 mg kg-1, against castor oil- and PGE2-induced diarrhoea in mice, but not when magnesium sulphate is used as a cathartic agent. It also delays rat small intestinal transit if this is accelerated with castor oil. However, the flavonoid does not modify the fluid transport across the colonic mucosa when it is administered intraluminally, either in normal conditions or when this transport is altered by PGE2 or sodium picosulphate. However, quercetin, the aglycone of quercitrin, increases the colonic fluid absorption only in the presence of secretagogue compounds, such as PGE2 and sodium picosulphate. It is concluded that the antidiarrhoeic activity of quercitrin is due to its aglycone, quercetin, which is released by the glycoside in the intestine.
authors.affiliation: Department of Pharmacology, School of Pharmacy, University of Granada, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gálvez
authors.forename: M E
authors.initials: ME
authors.lastname: Crespo
authors.forename: J
authors.initials: J
authors.lastname: Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Suárez
authors.forename: A
authors.initials: A
authors.lastname: Zarzuelo
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D002400:Cathartics / Q000494:pharmacology; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000930:Antidiarrheals; D000975:Antioxidants; D002400:Cathartics; C012526:quercitrin; D011794:Quercetin