Long-term potentiation in the avian hippocampus does not require activation of the N-methyl-D-aspartate (NMDA) receptor.
Evoked potentials recorded from slices of pigeon hippocampus were reversibly attenuated by 2 mM kynurenic acid. High frequency stimulation (3 x 200 Hz for 1 sec, with 1 sec intervals) evoked a persistent increase in the evoked potential, lasting in a nondecremental form for at least 2 hr. This increase in the magnitude of the potential was not blocked by antagonists of the NMDA receptor (APV and MK-801). These data suggest that the synaptic facilitation observed in the pigeon hippocampus, which appears to be a form of long-term potentiation, does not depend on the activation of NMDA receptors.
Wieraszko
A
A
College of Staten Island/CUNY, Center for Developmental Neuroscience and Developmental Disabilities 10301.
Ball
G F
GF
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D010856:Columbidae; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007736:Kynurenic Acid / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate; D007736:Kynurenic Acid