Effect of swimming-to-exhaustion stress on the Tyr-aminopeptidase activity in different brain areas of the rat.
It has been proposed that enkephalins play a role in stress phenomena. However, little is known concerning the effect of stress on the enzymes that may control the enkephalinergic activity. In the present paper we report the changes, after acute and chronic swimming-to-exhaustion stressor, of Tyr-aminopeptidase (which cleave the Tyr-Gly amide-bond) in discrete areas of the rat brain. After acute stress, only significant decreases in the striatum were observed. After chronic application, decreases in the striatum and increases in the hypothalamus and the medulla were seen.
De Gandarias
J M
JM
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Irazusta
J
J
Echevarria
E
E
Lagüera
M D
MD
Casis
L
L
D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003342:Corpus Striatum / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism; D005470:Fluorometry; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological; D013550:Swimming
D004745:Enkephalins; D011506:Proteins; D000626:Aminopeptidases