title: Increased c-fos expression in nucleus of the solitary tract correlated with conditioned taste aversion to sucrose in rats.
abstract: The pattern of neuronal activation in the rat nucleus of the solitary tract (NTS) in response to a standard gustatory stimulus was examined using c-Fos-like immunoreactivity (c-FLI) before and after conditioned taste aversion (CTA) formation. While unconditioned oral infusions of sucrose solution did not induce c-FLI in the NTS, after three pairings of sucrose with lithium chloride injections, sucrose induced c-FLI in the medial intermediate NTS 1 h after oral infusion. Extinction of the CTA by repeated infusions of sucrose alone reversed the induction of c-FLI.
authors.affiliation: E.W. Bourne Behavioral Research Laboratory, Department of Psychiatry, New York Hospital-Cornell Medical Center, White Plains 10605.
authors.forename: T A
authors.initials: TA
authors.lastname: Houpt
authors.forename: J M
authors.initials: JM
authors.lastname: Philopena
authors.forename: T C
authors.initials: TC
authors.lastname: Wessel
authors.forename: T H
authors.initials: TH
authors.lastname: Joh
authors.forename: G P
authors.initials: GP
authors.lastname: Smith
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D015870:Gene Expression / Q000187:drug effects*; D016762:Genes, fos / Q000187:drug effects*; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D051381:Rats; D017552:Solitary Nucleus / Q000187:drug effects / Q000502:physiology*; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000187:drug effects / Q000502:physiology*
chemical_list: D013395:Sucrose; D018021:Lithium Chloride