[The effect of the peroxidation of ribamidil-containing liposomes on the results of chemotherapy in experimental viral infections].
A relationship between ribamydil concentration and the intensity of accumulation of peroxidation products was found while storing ribamydil-containing liposomes which indicated a significant pro-oxidant activity of ribamydil. Increasing lethality of guinea pigs and white mice infected with Venezuelan equine encephalomyelitis virus was shown while using liposomal ribamydil containing from 4.78 to 6.82 nmol. ml-1 malonic dialdehyde which appeared to be associated with disordered function of the antioxidant system of the experimental animals.
Khamitov
R A
RA
Grabareva
L P
LP
Pshenichnov
V A
VA
Eres'kina
O A
OA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004685:Encephalomyelitis, Venezuelan Equine / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D005609:Free Radicals; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D051381:Rats; D012254:Ribavirin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012295:Rift Valley Fever / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality
D004337:Drug Carriers; D005609:Free Radicals; D008081:Liposomes; D012254:Ribavirin; D008315:Malondialdehyde
Vliianie perekisnogo okisleniia ribamidilsoderzhashchikh liposom na rezul'taty khimioterapii nekotorykh éksperimental'nykh virusnykh infektsiĭ.