A quantitative structure-activity relationship study of ligands exhibiting agonist and antagonist actions with cholecystokinin-receptors.
Observed biological activities of substituted phenyl urea/thiourea tetrapeptides as agonists with the cholecystokinin-alimentary canal (CCK-A) receptor, and (R)-4-benzamido-5-oxopentanoic acid derivatives with both peripheral (CCK-A) and the central (CCK-B) (brain) receptors have been shown to be correlated with various physicochemical, e.g. pi, sigma, and structural, e.g. Vw and dummy, I, parameters. These results were, then interpreted to predict promising criteria for having ligands with better affinity with the CCK receptors.
Singh
P
P
Department of Chemistry, S K Government College, Sikar, India.
Tiwari
S
S
Sharma
R C
RC
Ojha
T N
TN
D000595:Amino Acid Sequence; D008024:Ligands; D008969:Molecular Sequence Data; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000187:drug effects*; D013329:Structure-Activity Relationship
D008024:Ligands; D011949:Receptors, Cholecystokinin