title: Prognostic value of serum immunoglobulin A antibodies to pol gene products during HIV-1 infection.
abstract: Serum specimens from 66 HIV-1-infected subjects were tested by ELISA for the presence of IgA antibodies to HIV-1: 44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti-HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and to the level of serum IgA. A significative correlation (P < 0.03) was found between the absence of IgA to the subunit p68 of the reverse transcriptase and a count of CD4+ cell < 400/mm3 or total IgA level over 4.25 g/l. The same pattern was observed for the IgA antibodies to the p52 subunit but the association was just not significant (P < 0.07). No significant decrease was noted for the IgA directed towards the other proteins of HIV-1, especially the products of the gag gene.
authors.affiliation: Department of Immunology, Faculty of Medicine Jacques Lisfranc, Saint-Etienne, France.
authors.forename: A
authors.initials: A
authors.lastname: Quesnel
authors.forename: B
authors.initials: B
authors.lastname: Pozzetto
authors.forename: P
authors.initials: P
authors.lastname: Moja
authors.forename: F
authors.initials: F
authors.lastname: Grattard
authors.forename: F R
authors.initials: FR
authors.lastname: Lucht
authors.forename: J L
authors.initials: JL
authors.lastname: Touraine
authors.forename: O G
authors.initials: OG
authors.lastname: Gaudin
authors.forename: C
authors.initials: C
authors.lastname: Genin
mesh_terms: D000328:Adult; D000918:Antibody Specificity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015684:Gene Products, pol / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D011379:Prognosis
chemical_list: D015684:Gene Products, pol; D015483:HIV Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G