title: [Developmental changes in the concentrations of CSF neurotransmitter metabolites].
abstract: Changes in cerebrospinal fluid (CSF) neurotransmitter metabolite concentrations in 32 neurologically normal children aged 0 month to 7 years were analyzed to assess maturation of the central nervous system and compared to CSF from adults. Significant inverse correlations with aging were observed for tryptophan, 5-hydroxyindoleacetic acid, kynurenine, tyrosine, L-dihydroxyphenylalanine, dopamine, homovanillic acid and 3-methoxy-4-hydroxyphenylglycol concentrations. There were no significant differences with aging in CSF serotonin or 3-hydroxykynurenine concentrations. These findings demonstrated that changes in major CSF neurotransmitters occurred with aging during childhood. The importance of age-matched controls in studies of CSF neurotransmitter metabolites in the developing brain was emphasized.
authors.affiliation: Department of Pediatrics, St. Marianna University School of Medicine, Kanagawa.
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: B
authors.initials: B
authors.lastname: Egawa
authors.forename: K
authors.initials: K
authors.lastname: Horiguchi
authors.forename: A
authors.initials: A
authors.lastname: Kaku
authors.forename: K
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000375:Aging / Q000134:cerebrospinal fluid*; D001921:Brain / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018377:Neurotransmitter Agents / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents