Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism.
The gene encoding the human G-protein-coupled inwardly rectifying potassium channel designated GIRK1 (gene symbol, KCNJ3) was mapped to chromosome 2 by analyzing its segregation in a panel of human-hamster somatic cell hybrids. This assignment was confirmed by fluorescence in situ hybridization to metaphase chromosomes, and the gene was further localized to band 2q24.1. A highly informative simple tandem repeat DNA polymorphism of the form (CA)n was identified and used to localize KCNJ3 within the genetic map of the long arm of chromosome 2.
Stoffel
M
M
Howard Hughes Medical Institute, University of Chicago, Illinois 60637.
Espinosa
R
R
Powell
K L
KL
Philipson
L H
LH
Le Beau
M M
MM
Bell
G I
GI
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D006224:Cricetinae; D019204:GTP-Binding Proteins; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D011976:Receptors, Muscarinic / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
D015221:Potassium Channels; D011976:Receptors, Muscarinic; D019204:GTP-Binding Proteins