The ontogeny of morphological differences in the mandible in two inbred strains of mice.
We have analyzed the postnatal ontogeny of the mandible of two inbred strains of mice (C3HeB and C57/BL) with conventional statistical analysis of area traits and with Euclidian Distance Matrix Analysis (EDMA). The relative contribution of the distal tooth-bearing part of the mandible to the area of the whole mandible decreases over time. The most prominent differences in shape between mice of 10 days and 25 days postnatal age are found in the lower posterior part of the mandible. Between angular and condylar process intramembranous ossification proceeds at a high rate and gradually fills the space between these two processes. The position of the proximal end of the molar tooth-row is relocated ventrally during this period. Morphological differences between C3H and C57 are most pronounced at 15 days postnatal age. Regions that discriminate best between the two strains change during development. While differences in the coronoid process separate the two groups clearly at 10 and 25 days postnatal age, no significant differences in the coronoid process are found at 20 days postnatal age. Similarly, masseter area shows significant differences at 15 and 25 days postnatal age, while C57 and C3H mice are equivalent for this trait at the other times. The same qualitative results are obtained by Euclidian Distance Matrix Analysis (EDMA): regions of major differences between strains are not consistent among ages. These results suggest that the ontogeny of morphological differences between closely related taxa is quite an erratic process; development of morphometric differences does not proceed smoothly and continuously. This unpredictable pattern of development of morphometric differences is expected if development of the mandible is tightly integrated by epigenetic and regulatory processes.
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Department of Genetics, North Carolina State University, Raleigh 27695-7614.
Atchley
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Xu
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D000367:Age Factors; D000818:Animals; D008334:Mandible / Q000033:anatomy & histology* / Q000254:growth & development*; D008335:Mandibular Condyle / Q000033:anatomy & histology / Q000254:growth & development; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009024:Morphogenesis; D013045:Species Specificity; D013223:Statistics as Topic / Q000379:methods