title: Trends in the susceptibility of tuberculosis in New York City, 1987-1991. New York City Area Tuberculosis Working Group.
abstract: The annual number of cases of tuberculosis in New York City has increased since 1978. In addition, in 1991 a 1-month survey of cases of tuberculosis in New York City found that 33% of all cases were resistant to at least one drug. To determine susceptibility trends from 1987 to 1991, a period during which an unprecedented rise in resistant tuberculosis occurred in New York City, we reviewed the microbiology records of 44 New York City hospitals (comprising > 14,000 cases). The percentage of cases resistant to at least one drug rose from 19% in 1987 to 28% in 1991, and the percentage of cases resistant to isoniazid rose from 13% in 1987 to 23% in 1991, while resistance to at least both isoniazid and rifampin rose from 6% to 14%. The rise of multidrug-resistant tuberculosis occurred in all four surveyed boroughs (counties) of New York City. These data demonstrate how rapidly multidrug-resistant tuberculosis can appear, and they suggest that initial empirical regimens should be broadened at certain hospitals.
authors.affiliation: Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: K A
authors.initials: KA
authors.lastname: Sepkowitz
authors.forename: E E
authors.initials: EE
authors.lastname: Telzak
authors.forename: S
authors.initials: S
authors.lastname: Recalde
authors.forename: D
authors.initials: D
authors.lastname: Armstrong
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D015982:Bias; D004352:Drug Resistance, Microbial; D006801:Humans; D015994:Incidence; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D012189:Retrospective Studies; D013997:Time Factors; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents