Transfer of a genetic form of epilepsy in the chicken by embryonic brain grafts.
The genetic photosensitive epilepsy of the Fayoumi chickens was transferred to normal chickens by grafting, in situ, on the 2nd day of incubation, the prosencephalic and mesencephalic vesicles from epileptic embryos. Such chimeras displayed typical interictal EEG and developed intermittent light stimulation-induced seizures phenotypically and electrically similar to the epileptic strain seizures.
Teillet
M A
MA
Institut d'Embryologie Cellulaire et Moléculaire, CNRS-UMRC 9924, Collège de France, Nogent-sur-Marne, France.
Guy
N T
NT
Schuler
B
B
Le Gal La Salle
G
G
Batini
C
C
Le Douarin
N M
NM
Naquet
R
R
D000818:Animals; D016380:Brain Tissue Transplantation; D002642:Chick Embryo / Q000637:transplantation*; D004569:Electroencephalography; D004576:Electromyography; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology; D004848:Epithelium / Q000637:transplantation; D016332:Fetal Tissue Transplantation; D018183:Transplantation Chimera