[Amplification of C-myc oncogene in squamous cell carcinoma of the larynx].
C-myc amplification in 22 squamous cell carcinomas and 10 normal tissues (control) from the larynx was assessed by dot hybridization technique. Significant amplification of C-myc oncogene was found in malignant tumours as compared with the normal tissues. The extent of amplification also correlated with advanced tumour stages. There was a significant increase in C-myc amplification in TNM stages III and IV when compared with the stages I and II. These data suggested that C-myc oncogene might be activated by gene amplification and it might have a key role in determining the aggressiveness of laryngeal carcinoma.
Liu
S
S
Lin
D
D
Hong
B
B
Huang
G
G
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging