Significance of alpha-tocopherol and interleukin 8 in septic adult respiratory distress syndrome.
To elucidate the relationship between active oxygen and interleukin 8 (IL-8) in patients with septic adult respiratory distress syndrome (ARDS), we determined the serum levels of alpha-tocopherol, which has an antioxidant action, and IL-8 in seven patients with this disease. Serum alpha-tocopherol and IL-8 levels determined at the time of diagnosis of septic ARDS were 0.97 +/- 0.36 mg/dl and 0.98 +/- 0.99 ng/ml, respectively. A significant correlation was found between serum alpha-tocopherol level and IL-8 level (r = -0.758, p = 0.0473). These findings suggest that IL-8 activates neutrophils, which produce active oxygen.
Nakae
H
H
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Endo
S
S
Inada
K
K
Kasai
T
T
Yoshida
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000097:blood* / Q000276:immunology; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000276:immunology; D014810:Vitamin E / Q000097:blood*
D016209:Interleukin-8; D017382:Reactive Oxygen Species; D014810:Vitamin E