title: Radiologic appearance of the irradiated larynx. Part II. Primary site response.
abstract: OBJECTIVE
  To evaluate the computed tomographic (CT) appearance of laryngeal tumors treated with radiation therapy and the ability of CT to depict persistent or residual tumor.
  
  
  METHODS
  Sixty-one patients with primary squamous cell carcinoma of the larynx or hypopharynx were treated with definitive radiation therapy. CT was performed in all patients before and after treatment.
  
  
  RESULTS
  In 32 of 41 patients with cancer controlled at the primary site, CT showed complete resolution of tumor, whereas in 10 of 14 patients in whom radiation therapy failed, there was minimal or no reduction in tumor. In a subpopulation of patients who underwent repeat imaging, 18 of 19 with tumor controlled at the primary site had complete resolution of tumor. Overall, in four of 13 patients with 50%-75% reduction in tumor size or persistent substantial asymmetry at CT, therapy eventually failed at the primary site.
  
  
  CONCLUSIONS
  Lesions that are reduced by 50% or less at 4-month follow-up CT are highly suspicious for treatment failure. Repeat CT studies every 4 months is recommended in addition to careful clinical follow-up.
authors.affiliation: Department of Radiology, University of Florida College of Medicine, Shands Teaching Hospital, Gainesville.
authors.forename: S K
authors.initials: SK
authors.lastname: Mukherji
authors.forename: A A
authors.initials: AA
authors.lastname: Mancuso
authors.forename: I M
authors.initials: IM
authors.lastname: Kotzur
authors.forename: W M
authors.initials: WM
authors.lastname: Mendenhall
authors.forename: P S
authors.initials: PS
authors.lastname: Kubilis
authors.forename: R P
authors.initials: RP
authors.lastname: Tart
authors.forename: D
authors.initials: D
authors.lastname: Freeman
authors.forename: W R
authors.initials: WR
authors.lastname: Lee
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000532:radiotherapy*; D007830:Larynx / Q000000981:diagnostic imaging* / Q000528:radiation effects*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000453:epidemiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure