title: Differential effects of the (+)- and (-)-gossypol enantiomers upon Entamoeba histolytica axenic cultures.
abstract: The in-vitro anti-amoebic effects of (+/-)-, (+)-, (-)-gossypol and emetine were tested against axenic trophozoites from five Entamoeba histolytica strains. The (-)-isomer was more active than the racemate and the (+)-isomer. These results indicate that the gossypol anti-amoebic activity is mainly due to its content of (-)-gossypol in all strains tested.
authors.affiliation: Unidad de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Leon.
authors.forename: M T
authors.initials: MT
authors.lastname: González-Garza
authors.forename: S A
authors.initials: SA
authors.lastname: Matlin
authors.forename: B D
authors.initials: BD
authors.lastname: Mata-Cárdenas
authors.forename: S
authors.initials: S
authors.lastname: Said-Fernández
mesh_terms: D000818:Animals; D004748:Entamoeba histolytica / Q000187:drug effects*; D006072:Gossypol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
chemical_list: D006072:Gossypol