[Experimental study of Chinese Agkistrodon acutus venom in activation of rabbit platelets in vivo].
Fourteen Albino rabbits, male and female, were allocated randomly into two groups: control group which had intravenous infusion of normal saline, and experimental group which had intravenous infusion of Chinese Agkistrodon Acutus venom (CAAV) 0.075 mg/kg. Platelet was reduced, plasma PF4 activity and 5-HT concentration increased, 5-HT content in platelets was reduced in the experimental group 10, 20, and 50 minutes after the infusion. It had a significant difference (P < 0.01), compared with that in the control group. Platelets were aggregated into masses under electron microscope 10 minutes after the infusion of CAAV. The study has proved that blood platelets in rabbits are activated by Chinese Agkistrodon Acutus venom.
Wang
C
C
Deng
C
C
Li
G
G
D017836:Agkistrodon; D000818:Animals; D003435:Crotalid Venoms / Q000494:pharmacology*; D005260:Female; D008297:Male; D010972:Platelet Activating Factor / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011817:Rabbits; D011897:Random Allocation; D012701:Serotonin / Q000097:blood
D003435:Crotalid Venoms; D010972:Platelet Activating Factor; D012701:Serotonin