Sex difference in sensitization to the locomotor effects of mazindol in rats.
Male and female rats were treated daily for 7 days with mazindol (5, 10, and 20 mg/kg), an anorectic drug, and tested in the open field. Mazindol developed sensitization to its locomotor stimulatory effect in both sexes on day 7 with a nondose-dependent pattern of response. However, the locomotor activity appeared to be sex dependent, female rats being more sensitive. Following a challenge dose of mazindol (10 and 20 mg/kg) on day 10, a marked enhancement of locomotion was seen in female rats. These findings indicate that repeated administration of mazindol produces sex-dependent sensitization to its effect on locomotor behavior.
Zanin
M
M
Departamento Farmacologia, Universidade Federal de Santa Catarina, Florianópolis Santa Catarina, Brasil.
Takahashi
R N
RN
D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008454:Mazindol / Q000008:administration & dosage / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013268:Stimulation, Chemical
D008454:Mazindol