Reduced kallikrein excretion by liposome-encapsulated cyclosporin in the rat.
Different phospholipids and methods of preparation were used to produce cyclosporin encapsulated in liposomes. The optimal formulation of cyclosporin-liposome was compared to the oily cyclosporin after intraperitoneal administration of 25 mg kg-1 body weight to rats. Urinary kallikrein excretion was significantly reduced with the liposomal form. The abrupt increase of kallikrein excretion after the tenth day with the control oil preparation suggests that cyclosporin toxicity could be present at the tubular level, and the encapsulation of cyclosporin in liposomes reduces tubular damage.
Akbarieh
M
M
Faculty of Pharmacy, University of Montreal, Quebec, Canada.
Adam
A
A
Legris
F
F
Tawashi
R
R
D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007610:Kallikreins / Q000652:urine*; D008081:Liposomes; D009821:Oils; D011188:Potassium / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000652:urine; D013053:Spectrophotometry; D013535:Suspensions
D008081:Liposomes; D009821:Oils; D013535:Suspensions; D016572:Cyclosporine; D012964:Sodium; D007610:Kallikreins; D011188:Potassium