[Epidermal growth factor receptor in non-small cell cancer of the lung].
In this study we determined the concentration of epidermic growth factor receptors (EGFr) in non-small cell carcinoma of the lung (NSCCL) and analyzed its relation to the anatomical, pathological and clinical factors of these neoplasms. The concentration of EGFr in 62 tumor tissue samples was 9.9 +/- 14 fmol/mg, higher than that found in 14 tissue samples from cases of spontaneous pneumothorax (3.9 +/- 3.6 fmol/mg) (p = 0.005). EGFr concentration in lung tissue with no signs of neoplasm was 6.5 +/- 10 fmol/mg. In 21 (33%) cases of NSCCL the concentration exceeded the normal threshold of 10 fmol/mg. EGFr concentration was higher in cases of epidermoid carcinoma than in other tissue samples (p = 0.042). No significant association was found between EGFr levels and status of tumor node metastasis, degree of differentiation and mitotic index. The probability of remaining free of tumor recurrence and of survival after 24 months among patients whose tumoral EGFr concentration was below 10 fmol/mg was 34 and 40%, respectively. The rates for patients with concentrations that exceeded the threshold were 20% (p = 0.32) and 25% (p = 0.26), respectively. The results seem to indicate that the study of EGFr concentration alone does not yield practically important information for the management of patients with NSCCL who have undergone surgery. The concentration of EGFr marks degree of differentiation in NSCCL and has prognostic implications derived from its association with other factors.
Díez
M
M
Servicio de Cirugía General, Hospital Universitario, Alcalá de Henares, Madrid.
Maestro
M L
ML
Torres
A
A
Hernando
F
F
Ortega
M D
MD
García-Asenjo
J A
JA
Picardo
A
A
Mugüerza
J M
JM
Sánchez-Pernaute
A
A
Balibrea
J L
JL
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D000368:Aged; D018287:Carcinoma, Large Cell / Q000737:chemistry / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009364:Neoplasm Recurrence, Local; D011030:Pneumothorax / Q000175:diagnosis; D011379:Prognosis
D066246:ErbB Receptors
Receptor para el factor de crecimiento epidérmico en el cáncer de pulmón no microcítico.