title: [The resolution of a mitral valve prosthesis thrombosis with low-dose plasminogen tissue activator and the role of Doppler echocardiographic monitoring].
abstract: The case of a 63-year-old woman with a Bjork-Shiley mitral valve prosthesis who developed acute thrombosis of mitral prosthesis and acute pulmonary edema is described. Full clinical success was achieved with medical therapy with tissue-type plasminogen activator. The dosage of drug was titrated by serial echo-Doppler examinations of prosthetic structures and functional area. A low-dose (60 mg over 1 hour) of tissue-type plasminogen activator was sufficient to obtain thrombus resolution. Embolic or hemorrhagic complications were absent. This is the first report of successful use of Doppler echocardiography titrated low-dose of tissue-type plasminogen activator for acute thrombosis of mitral prosthetic valve.
authors.affiliation: Servizio di Cardiologia, Ospedale S. Bartolomeo, Sarzana.
authors.forename: D
authors.initials: D
authors.lastname: Bertoli
authors.forename: G
authors.initials: G
authors.lastname: Filorizzo
authors.forename: F
authors.initials: F
authors.lastname: Vivaldi
authors.forename: R
authors.initials: R
authors.lastname: Petacchi
mesh_terms: D000208:Acute Disease; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging; D011475:Prosthesis Failure; D011654:Pulmonary Edema / Q000000981:diagnostic imaging / Q000188:drug therapy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010959:Tissue Plasminogen Activator
vernacular_title: Risoluzione di trombosi di protesi valvolare mitralica con basso dosaggio di attivatore tissutale del plasminogeno e ruolo del monitoraggio ecocardiografico Doppler.