Neurobehavioral presentations of the antiphospholipid antibody syndrome.
Antiphospholipid antibodies, including lupus anticoagulant and anticardiolipin antibodies, are increasingly recognized as a cause of neurological morbidity. They may occur with or without evidence of systemic lupus erythematosus and have been associated with stroke, migraine, and confusional states. Their role as etiologic or contributing factors in neurobehavioral and neuropsychiatric syndromes of obscure etiology has not been emphasized. The cases of 7 patients who were referred for evaluation of behavior abnormalities and had antiphospholipid antibodies are presented, and the potential relationships of the antiphospholipid antibody syndrome to behavioral alterations are discussed.
Gorman
D G
DG
Department of Neurology, UCLA School of Medicine.
Cummings
J L
JL
D000328:Adult; D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000032:analysis / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000188:drug therapy / Q000276:immunology / Q000523:psychology*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D001923:Brain Chemistry; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis / Q000276:immunology*; D011859:Radiography; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D017153:Antibodies, Anticardiolipin; D014150:Antipsychotic Agents; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids