Seizure after reversal of benzodiazepine treatment with flumazenil: a report of two cases.
Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam. The use of benzodiazepine for sedation in ICU may mask valuable information relevant to an ongoing pathological change. The seizure in our patients seemed most likely to result from septic encephalopathy which was unmasked by flumazenil. However, flumazenil has the potential to provoke seizure and should be used with caution.
Ng
K O
KO
Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Tang
G J
GJ
Hseu
S S
SS
Hsing
C H
CH
Lee
T Y
TY
D000368:Aged; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005442:Flumazenil / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018079:Receptors, GABA / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*
D018079:Receptors, GABA; D005442:Flumazenil; D003975:Diazepam