Effect of protein kinase inhibitors on the invasion process of macrophages by Trypanosoma cruzi.
The interaction of Trypanosoma cruzi with different vertebrate cells involves two distinct steps, attachment and internalization. Genistein and staurosporine, drugs which inhibit protein kinases, specially tyrosine kinase, are able to block the infection of macrophages by T. cruzi, suggesting that protein phosphorylation is a key event on this process.
Vieira
M C
MC
Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
de Carvalho
T U
TU
de Souza
W
W
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D019833:Genistein; D007529:Isoflavones / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000469:parasitology*; D051379:Mice; D047428:Protein Kinase Inhibitors; D019311:Staurosporine; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000502:physiology*
D000470:Alkaloids; D007529:Isoflavones; D047428:Protein Kinase Inhibitors; D019833:Genistein; D019311:Staurosporine