In-vitro permeability to salicylic acid of human, rodent, and shed snake skin.
In-vitro permeability to salicylic acid of human, rodent, and shed snake skin has been examined for the purpose of selecting model membranes for human skin corresponding to different anatomic sites, since a marked regional variation is suggested among the different sites. The greatest permeability to salicylic acid was observed in the scrotum, that of the sole was negligible. The cheek, neck, and inguinal skin seemed more permeable than the breast, back, thigh, lower leg, or foot skin. Shed snake and skin of hairless rat were found to show similar permeability to human breast and thigh skin. Wistar rat and nude mouse skin showed similar permeability to human cheek, neck, and inguinal skin.
Harada
K
K
Department of Pharmaceutics and Therapeutics, Hiroshima University School of Medicine, Japan.
Murakami
T
T
Kawasaki
E
E
Higashi
Y
Y
Yamamoto
S
S
Yata
N
N
D000818:Animals; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D012459:Salicylates / Q000493:pharmacokinetics*; D020156:Salicylic Acid; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012911:Snakes; D013045:Species Specificity
D012459:Salicylates; D020156:Salicylic Acid