Reduced formation of high molecular weight DNA in murine gliomas treated with nitrosourea and chlorpromazine.
We have examined the formation of DNA in rat glioma cells. Cytotoxicity was induced in the cells using BCNU (1,3-bis(2-chloroethyl)-1-nitroso-urea) in the presence or absence of CPZ (chlorpromazine). There was impaired formation of DNA in cells treated with BCNU. This was further enhanced in cells treated with both BCNU and CPZ. In the latter case we did not find any intact high molecular weight DNA.
Aas
A T
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Department of Neurosurgery, University of Lund, Sweden.
Salford
L G
LG
Lönn
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Lönn
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D000818:Animals; D002147:Calmodulin / Q000502:physiology; D002330:Carmustine / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011916:Rats, Inbred F344; D014407:Tumor Cells, Cultured
D002147:Calmodulin; D004247:DNA; D002746:Chlorpromazine; D002330:Carmustine