An in vivo study on active cytomegalovirus infection in relation to active HIV replication in HIV-I infected drug addicts.
Human cytomegalovirus (CMV) is a major cause of severe disease in HIV-infected persons and some findings suggest that it may accelerate HIV disease. In this study, a total of 621 blood samples from patients with LAS-ARC and AIDS were analysed in parallel for CMV and HIV-I antigenaemias. Results indicate that the presence of CMV antigenaemia and the presence of HIV-I p24 in the blood are highly correlated statistically and encourage other studies on the role of CMV in the evolution of AIDS. In a smaller group of cases, CMV was also isolated from saliva and/or urine. The correlation with HIV replication was positive (although much lower) with CMV detected in saliva and completely negative with CMV isolated from urine.
Lazzarotto
T
T
Institute of Microbiology, University of Bologna, Italy.
Campisi
B
B
Re
M C
MC
Albertini
F
F
Furlini
G
G
Dala Casa
B
B
Landini
M P
MP
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000382:microbiology; D000956:Antigens, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000382:microbiology; D016655:HIV Core Protein p24 / Q000097:blood; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D012463:Saliva / Q000382:microbiology; D019966:Substance-Related Disorders; D014779:Virus Replication
D000956:Antigens, Viral; D016655:HIV Core Protein p24