[Jejunal myenteric denervation induced by benzalkonium chloride].
The effects of benzalkonium chloride (BAC) on the number of myenteric neurons, muscle thickness and external perimeter after acute (until 10 days after BAC application) and chronic (30 and 60 days after BAC application) denervation of the proximal jejunum were determined in rats. There was a significant reduction in the number of myenteric neurons of all segments treated with BAC. The extent of denervation varied along the time, and it was reduced in the denervated segments of the chronic group in comparison with the acute group. This may be due to the neuroplasticity phenomenon appearing during the chronic phase. Myenteric denervation increased the thickness of the propria muscle layer, especially in the longitudinal muscle layer, suggesting a higher sensitivity of this layer to myenteric denervation.
Ramalho
F S
FS
Departamento de Patologia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo.
Santos
G C
GC
Ramalho
L N
LN
Kajiwara
J K
JK
Zucoloto
S
S
D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D016022:Case-Control Studies; D007583:Jejunum / Q000294:innervation*; D008297:Male; D009121:Muscle Denervation; D009197:Myenteric Plexus / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001548:Benzalkonium Compounds
Desnervação mioentérica jejunal induzida pelo cloreto de benzalcônio.