Interleukin-8 antitumour effect is associated with a local infiltration but not with a systemic activation of T lymphocytes.
In a model of colon cancer in rats (peritoneal carcinomatosis), IL-8 was found to have a highly reproducible antitumoural effect. During IL-8-induced tumour regression the infiltration of nodules by CD4+ T lymphocytes was enhanced. However, splenic lymphocytes did not proliferate in response to tumour cells in vitro. IL-8 antitumour effect was associated with a local but not with a systemic activation of T lymphocytes.
Reisser
D
D
Groupe de Recherche sur les Cancers Digestifs, Faculty of Medicine, Dijon, France.
Lejeune
P
P
Lagadec
P
P
Onier
N
N
Dasilva
C
C
Lindley
I
I
Jeannin
J F
JF
D000818:Animals; D016209:Interleukin-8 / Q000494:pharmacology / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects*; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects*
D016209:Interleukin-8