title: The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland.
abstract: The U.S. National Cancer Institute and the Finnish National Public Institute jointly sponsored a large double-blind, placebo-controlled primary-prevention trial to examine the effects of vitamin E and beta-carotene supplementation on reducing the incidence of lung cancers in male smokers, ages 50-69 years. Supplementation did not result in a significant reduction in lung cancer, and a higher incidence of lung cancer was observed in the group receiving beta-carotene. These results should be examined within the context of the population studied before they are cited as definitive.
authors.affiliation: USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
authors.forename: J
authors.initials: J
authors.lastname: Blumberg
authors.forename: G
authors.initials: G
authors.lastname: Block
mesh_terms: D000368:Aged; D002338:Carotenoids / Q000627:therapeutic use*; D015331:Cohort Studies; D004311:Double-Blind Method; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012042:Registries; D012907:Smoking / Q000009:adverse effects; D014810:Vitamin E / Q000627:therapeutic use*; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids