Synthesis and muscle relaxant activity of cyclic baclofen analogues.
Some new cyclic analogues of baclofen have been prepared and characterized, starting from 4-(4-chlorophenyl)-pyrrolidone. When tested in comparison with the parent compound, they exhibited only a moderate muscle relaxant activity.
Pifferi
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Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Italy.
Nizzola
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R
Cristoni
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A
D000284:Administration, Oral; D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D009125:Muscle Relaxants, Central; D001418:Baclofen