Inducibility of gamma-glutamyltransferase by dexamethasone in rat liver: relationship with the cytochrome P-450 content.
Gamma-glutamyltransferase (GGT) inducibility by dexamethasone (DEX) in rat liver decreased by about 95% within the first 14 days of life, while the liver content of cytochrome P-450 (P-450) increased by about 500%. Cobaltic Protoporphyrin IX (CPP), given on the 9th day of life, caused a temporary depression of the P-450 liver content, with maximal effects 3 and 4 days after the administration of CPP. GGT induction by DEX was significantly higher in CPP-treated rats than in untreated ones, with maximum induction coinciding with the maximal decrease of P-450. These effects were CPP dose-dependent.
Paolicchi
A
A
Dipartimento di Biomedicina, Università di Pisa, Italy.
Chieli
E
E
Rugiu
E S
ES
Tongiani
R
R
D000704:Analysis of Variance; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D011524:Protoporphyrins / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D011524:Protoporphyrins; C007095:cobaltiprotoporphyrin; D003907:Dexamethasone; D003577:Cytochrome P-450 Enzyme System; D005723:gamma-Glutamyltransferase