title: Atrial natriuretic factor: plasma concentration and specific binding to renal glomeruli during the development of genetic hypertension in rats of the Lyon strain.
abstract: 1. The pathophysiologic role of atrial natriuretic factor (ANF) in genetic hypertension was investigated in 5- and 21-week-old genetically hypertensive (LH), normotensive (LN) and low blood pressure (LL) rats of the Lyon strain. 2. Plasma ANF was significantly higher in 5-week-old LH than in age-matched LN and LL animals. It tended to be lower in 21-week-old LH than in LN rats. 3. Left and right atrial ANF content was also significantly lower at 21 weeks in the LH group. 4. Glomerular ANF receptors showed a significant decrease in LH in comparison to LL and LN animals.
authors.affiliation: Laboratoire de Physiologie de l'Environement, Faculté de Médecine Lyon, Grange-Blanche, France.
authors.forename: G
authors.initials: G
authors.lastname: Gauquelin
authors.forename: J
authors.initials: J
authors.lastname: Gutkowska
authors.forename: M
authors.initials: M
authors.lastname: Vincent
authors.forename: J
authors.initials: J
authors.lastname: Sassard
authors.forename: C
authors.initials: C
authors.lastname: Gharib
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D006400:Hematocrit; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D011485:Protein Binding; D051381:Rats
chemical_list: D009320:Atrial Natriuretic Factor