Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine.
The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.
Kahn
R S
RS
Department of Psychiatry, Mount Sinai School of Medicine/Bronx Veterans Administration Hospital, New York, NY.
Davidson
M
M
Siever
L J
LJ
Sevy
S
S
Davis
K L
KL
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000037:antagonists & inhibitors*; D011388:Prolactin / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000037:antagonists & inhibitors*; D013997:Time Factors
D010879:Piperazines; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003024:Clozapine; C015068:1-(3-chlorophenyl)piperazine