Postprandial thermogenesis of rats with glutamate induced obesity in relation to energy intake.
Postprandial thermogenesis was estimated in 4-month-old male rats with glutamate induced obesity after being fed with 300, 450 and 600 kJ/kg0.75 of a pellet diet, respectively by indirect calorimetry in computer-controlled open circuit metabolic cages over 8 h. After an intake of 600 kJ/kg0.75 (above the maintenance energy requirement) postprandial thermogenesis was significantly reduced in the obese animals to about 40% of control rats (12.0 versus 31.5 kJ/kg0.75 x 8h). It is concluded that the glutamate obese rat can be accepted as an animal model with impaired facultative thermogenesis, mainly caused by a reduction of sympathetic adrenergic activity.
Aust
L
L
German Institute for Human Nutrition, Bergholz-Rehbrücke, FRG.
Frenz
U
U
Noack
R
R
Proll
J
J
D000818:Animals; D001833:Body Temperature Regulation; D002153:Calorimetry, Indirect; D004195:Disease Models, Animal; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism; D005971:Glutamates; D018698:Glutamic Acid; D008297:Male; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005971:Glutamates; D018698:Glutamic Acid