title: Idiopathic CD4+ T-lymphocytopenia--an analysis of five patients with unexplained opportunistic infections.
abstract: BACKGROUND
  Although patients with idiopathic CD4+ T-lymphocytopenia and serious opportunistic infections have been described previously, the clinical and immunologic features of this condition have not been well defined.
  
  
  METHODS
  We studied in detail five patients with idiopathic CD4+ T-lymphocytopenia. The studies included serologic testing, culture, and polymerase chain reaction for the human immunodeficiency virus (HIV) types 1 and 2, serologic testing for the human T-cell lymphotropic virus (HTLV) types I and II, lymphocyte phenotyping, immunoglobulin quantitation, and lymphocyte-transformation assays, as well as attempts to isolate a retroviral agent. The results were compared with those in HIV-infected persons matched for CD4+ T-cell counts and with those in normal controls. We also studied the spouses of patients and the blood donors for one patient.
  
  
  RESULTS
  In these five patients, there was no evidence of either HIV or HTLV infection. All the patients had both low percentages and low counts of CD4+ T cells, with relative increases in percentages, but not counts, of CD8+ cells. Numbers of B cells and natural killer cells were generally normal. As compared with HIV-infected persons, our patients had lower percentages and counts of CD8+ cells and more lymphopenia. CD4+ counts were relatively stable over time. Instead of the high immunoglobulin levels seen in HIV infection, these patients had normal or slightly low levels of immunoglobulins. The lymphocyte-transformation response to mitogens and antigens was depressed. Results in spouses and blood donors were normal.
  
  
  CONCLUSIONS
  Idiopathic CD4+ T-lymphocytopenia differs from HIV infection in its immunologic characteristics and in its apparent lack of progression over time. Nothing about the immunologic or viral-culture studies performed in these patients or about their family members or blood donors suggests that a transmissible agent causes this condition.
authors.affiliation: Immunology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333.
authors.forename: T J
authors.initials: TJ
authors.lastname: Spira
authors.forename: B M
authors.initials: BM
authors.lastname: Jones
authors.forename: J K
authors.initials: JK
authors.lastname: Nicholson
authors.forename: R B
authors.initials: RB
authors.lastname: Lal
authors.forename: T
authors.initials: T
authors.lastname: Rowe
authors.forename: A C
authors.initials: AC
authors.lastname: Mawle
authors.forename: C B
authors.initials: CB
authors.lastname: Lauter
authors.forename: J A
authors.initials: JA
authors.lastname: Shulman
authors.forename: R A
authors.initials: RA
authors.lastname: Monson
mesh_terms: D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015483:HIV Antibodies / Q000032:analysis; D015497:HIV-1 / Q000302:isolation & purification; D015498:HIV-2 / Q000302:isolation & purification; D015367:Human T-lymphotropic virus 2 / Q000302:isolation & purification; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008231:Lymphopenia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications*; D016133:Polymerase Chain Reaction
chemical_list: D016827:CD8 Antigens; D015483:HIV Antibodies; D007136:Immunoglobulins