[The antioxidant defense system in hypertension patients on a diet enriched with omega 3 polyunsaturated fatty acids and alpha-tocopherol].
A state of the anti-oxidation system in blood and the rate of lipid peroxidation were studied in patients with hypertension. High sensitivity of the anti-oxidation system enzymes to alterations in the diet fat composition was detected in the patients, nutrition of whom was evaluated in detail. Excessive doses of alpha-tocopherol, added to the diet enriched with omega 3-polyunsaturated fatty acids normalized lipid peroxidation and stabilized the enzyme activity involved in the anti-oxidation system. The integral parameter, proposed for evaluation of the anti-oxidation protection state and designated as "anti-oxidation index" involved estimation of catalase, superoxide dismutase, glutathione reductase and peroxidase activities as well as of content of malonic dialdehyde and diene conjugates in erythrocytes.
Vasil'ev
A V
AV
Biiasheva
I R
IR
Pokrovskaia
G R
GR
Mal'tsev
G Iu
GIu
Varsanovich
E A
EA
Orlova
L A
LA
Soto
S Kh
SKh
D000975:Antioxidants; D002374:Catalase / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000178:diet therapy / Q000201:enzymology; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
Issledovanie sistemy antiokislitel'noĭ zashchity u bol'nykh gipertonicheskoĭ bolezn'iu pri obogashchenii diety polinenasyshchennymi zhirnymi kislotami omega3 i alpha-tokoferolom.