Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues.
The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.
Lai
Z C
ZC
Howard Hughes Medical Institute, University of California, Berkeley 94720.
Rushton
E
E
Bate
M
M
Rubin
G M
GM
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000032:analysis / Q000235:genetics*; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000502:physiology; D005260:Female; D005801:Genes, Homeobox; D007150:Immunohistochemistry; D008297:Male; D008648:Mesoderm / Q000502:physiology*; D008969:Molecular Sequence Data; D009132:Muscles / Q000166:cytology / Q000196:embryology; D009420:Nervous System / Q000196:embryology; D009424:Nervous System Physiological Phenomena; D009928:Organ Specificity; D012097:Repressor Proteins; D016335:Zinc Fingers / Q000235:genetics*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D012097:Repressor Proteins; C081010:zfh1 protein, Drosophila