A convenient synthesis of new substituted pyrazolo[4,3-c]quinolines with potential antiinflammatory activity.
2,4-Dichloro-quinoline-3-carbonitrile 1 reacts with hydrazines to afford pyrazolo[4,3-c]quinolines 5a, b. The reaction of 5a with sodium azide; hydrogen/Pd; triethylorthoformate; cyclohexylamine; piperidine; morpholine and acetic anhydride resulted in the corresponding heterocyclic derivatives 6-15.
Mekheimer
R
R
Chemistry Department, Faculty of Science, Minia University, Egypt.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D006834:Hydrazines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006834:Hydrazines; D009570:Nitriles; D011720:Pyrazoles; D011804:Quinolines