title: Polymorphic tandem repeat region in interleukin-1 alpha intron 6.
abstract: Analysis of polymerase chain reaction amplified products from the sixth intron of the human interleukin-1 alpha gene reveals a high polymorphism (polymorphism information content = 0.51) in a Caucasian population. Altogether, seven alleles have been defined ranging from 620 to 1220bp. This polymorphism is probably attributable to a variable number of 46-bp tandem repeats, each containing potential regulatory sequences.
authors.affiliation: University Department of Medicine, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bailly
authors.forename: F S
authors.initials: FS
authors.lastname: di Giovine
authors.forename: G W
authors.initials: GW
authors.lastname: Duff
mesh_terms: D001483:Base Sequence; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*
chemical_list: D007375:Interleukin-1