Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum.
The impact of cocaine self-administration on the expression of striatal preprodynorphin and c-fos mRNA was examined with in situ hybridization histochemistry. Cocaine significantly increased preprodynorphin mRNA in the dorsal, but not ventral, striatum. Expression of c-fos mRNA in cocaine-administering rats did not differ from that in controls in all structures examined. These results indicate that the expression of preprodynorphin, but not c-fos, is upregulated in rat striatum as a consequence of cocaine self-administration. Furthermore, these data indicate that the regulation of preprodynorphin is dissociable from the expression of c-fos in rats exposed to repeated doses of cocaine.
Daunais
J B
JB
Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Roberts
D C
DC
McGinty
J F
JF
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004399:Dynorphins / Q000096:biosynthesis*; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos; D017403:In Situ Hybridization; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D011498:Protein Precursors / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012055:Reinforcement Schedule; D012646:Self Administration
D011498:Protein Precursors; D012333:RNA, Messenger; C036448:pre-prodynorphin; D004399:Dynorphins; D003042:Cocaine