Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.
OBJECTIVE
To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.


METHODS
Cross sectional population based study.


METHODS
980 people aged 69 to 78 (349 men, 631 women).


METHODS
Population of Kuopio, eastern Finland.


METHODS
Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.


RESULTS
46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.


CONCLUSIONS
Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.
Kuusisto
J
J
Department of Medicine, Kuopio University Hospital, Finland.
Koivisto
K
K
Kervinen
K
K
Mykkänen
L
L
Helkala
E L
EL
Vanhanen
M
M
Hänninen
T
T
Pyörälä
K
K
Kesäniemi
Y A
YA
Riekkinen
P
P
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D003430:Cross-Sectional Studies; D015161:Dementia, Multi-Infarct / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D011159:Population Surveillance; D015995:Prevalence; D011897:Random Allocation; D017678:Sex Distribution
D001057:Apolipoproteins E