Structural considerations on the iridoids as anti-inflammatory agents.
Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the highest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.
Recio
M C
MC
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
Giner
R M
RM
Máñez
S
S
Ríos
J L
JL
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D006027:Glycosides; D013729:Terpenes