title: Review article: lack of clinical significance of the interaction between H2-receptor antagonists and ethanol.
abstract: It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2-receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2-antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2-antagonists and ethanol is clinically insignificant.
authors.affiliation: Minneapolis Veterans Administration Medical Center, MN 55417.
authors.forename: M D
authors.initials: MD
authors.lastname: Levitt
mesh_terms: D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans
chemical_list: D006635:Histamine H2 Antagonists; D000431:Ethanol