The potential value of somatostatin receptor scintigraphy in medullary thyroid carcinoma.
In a prospective study, ten patients with recurrent medullary thyroid carcinoma (markedly elevated calcitonin levels) were investigated by means of somatostatin receptor scintigraphy (SRS) with 111Inpentetreotide. Scintigraphically, 30 sites of pathological uptake were found, mostly located in the neck and upper mediastinum. So far, 18 suspected tumour sites underwent histological examination and 14 of them could be verified as metastases of medullary thyroid carcinoma (MTC). The remaining four putative tumour lesions turned out to be false positive scintigraphic findings caused by chronic inflammation and somatostatin receptor positive tumours other than MTC. We conclude that SRS is a promising imaging modality for localization of MTC recurrence and may thus make a contribution to better management of this patient group.
Dörr
U
U
Department of Nuclear Medicine, Katharinenhospital, Stuttgart, Germany.
Frank-Raue
K
K
Raue
F
F
Sautter-Bihl
M L
ML
Guzman
G
G
Buhr
H J
HJ
Bihl
H
H
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000556:secondary*; D005069:Evaluation Studies as Topic; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000556:secondary*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000556:secondary*; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000502:physiology*; D013004:Somatostatin / Q000031:analogs & derivatives; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology
D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D013004:Somatostatin; C081788:pentetreotide