Synthetic glucocorticoids potentiate IgE synthesis. Influence of steroid and nonsteroid hormones on human in vitro IgE secretion.
Recently, hydrocortisone (HC) has been shown significantly to enhance interleukin-4 (IL-4)-induced in vitro IgE synthesis. For investigation of possible effects of synthetic corticosteroids but also of effects of other important human hormones, peripheral blood mononuclear cells (PBMC) were incubated with IL-4 and various concentrations of the hormones. IgE secreted in the supernatant was determined after a 14-d culture period. Like HC, all synthetic corticosteroids potentiated IgE secretion. A minor effect was noted for the mineralocorticoid aldosterone. No modulating effect on IL-4-induced IgE formation was observed for adrenocorticotropic hormone (ACTH), somatotropin (STH), thyroid-stimulating hormone (TSH), triiodothyronine, thyroxine, epinephrine, noradrenaline, insulin, and glucagon.
Nüsslein
H G
HG
Department of Internal Medicine III, University of Erlangen, Germany.
Weber
G
G
Kalden
J R
JR
D000450:Aldosterone / Q000276:immunology / Q000494:pharmacology*; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D005938:Glucocorticoids / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000276:immunology / Q000494:pharmacology*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000097:blood / Q000187:drug effects / Q000276:immunology; D015847:Interleukin-4 / Q000037:antagonists & inhibitors* / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D010907:Pituitary Hormones / Q000276:immunology / Q000494:pharmacology
D005938:Glucocorticoids; D010907:Pituitary Hormones; D015847:Interleukin-4; D007073:Immunoglobulin E; D000450:Aldosterone; D006854:Hydrocortisone