Blood lipid changes in hypertensive, dyslipidemic patients under long term quinapril treatment.
OBJECTIVE
The present study aimed at verifying Quinapril effects on both pressure and lipid profile in 15 patients (5 M, 10 F), aged 45 to 80 years (63 +/- 9), complaining for mild to moderate hypertension and dyslipidemia (total cholesterol > 200 mg/dl and triglycerides > 200 mg/dl). No relevant associated disease was present, including diabetes mellitus not any lipid lowering drugs were given.


METHODS
After a wash-out period of one week, all patients, who had been hypertensive for 2 to 120 months (33 +/- 11), were given Quinapril 20 mg orally once a day for 6 months and kept on a low lipid diet from before treatment to the end of the study. Lipid profile we assessed at three-month intervals.


RESULTS
Blood pressure, monitored at two-week intervals, significantly decreased on the 1st month (p < 0.001), and kept lower thereafter. Mean total cholesterol, triglycerides and low density lipoprotein cholesterol levels, after 6 months of therapy, were reduced by 44 mg/dl (p < 0.001), 29 mg/dl (p < 0.001) and 39 mg/dl (p < 0.002) respectively.


CONCLUSIONS
Our results seen indicate that Quinapril antihypertensive effects are accompanied by a significant improvement of the lipid profile.
Cangelosi
M M
MM
Unità Operativa Cardiologica, INRCA, National Institute of Research, Rome, Italy.
Gaudio
M
M
Brancati
A M
AM
Leggio
F
F
D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D007546:Isoquinolines / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D007546:Isoquinolines; D008055:Lipids; D008077:Lipoproteins, LDL; D044005:Tetrahydroisoquinolines; D014280:Triglycerides; D002784:Cholesterol; D000077583:Quinapril