title: Early postoperative increase in defibrillation threshold with nonthoracotomy system in humans.
abstract: The stability of the defibrillation threshold (DFT) early after implantation of an implantable cardioverter defibrillator was evaluated in 15 patients. All but one patient had a three lead nonthoracotomy system using a subcutaneous patch, a right ventricular endocardial lead, and a lead in coronary sinus (n = 5) or superior vena cava (n = 9). Shocks were delivered using simultaneous in nine, sequential in three, and single pathway (coronary sinus not used) in one patient. DFTs were measured at implant (n = 15), 2-8 days postoperation (postop, n = 15), and 4-6 weeks later (n = 8). The DFT was defined as the lowest energy shock that resulted in successful defibrillation. The DFT was assessed with output beginning at 18 joules or 2-4 joules above the implant DFT. All shocks were delivered in 2- to 4-joule increments or decrements. DFTs were significantly higher postoperatively than DFTs at implant (22.7 +/- 7.0 J vs 16.9 +/- 3.9 J; P < 0.05). Eight of 15 patients had DFT determined at all three study periods. In these patients, DFT increased at postop (22.8 +/- 8.3 J vs 16.4 +/- 3.9 J at implant; P < 0.05) and returned to baseline at 4-6 weeks (16 +/- 7.1 J vs 16.4 +/- 3.9 J at implant; P = N.S.). Thus, in patients with a multilead nonthoracotomy system, a DFT rise was observed early after implant. The DFT appears to return to baseline in 4-6 weeks. These results have important implications for programming energy output after implantable cardioverter defibrillator implantation.
authors.affiliation: Clinical Cardiac Electrophysiology Laboratory, University of Pennsylvania Hospital 19104.
authors.forename: H H
authors.initials: HH
authors.lastname: Hsia
authors.forename: R L
authors.initials: RL
authors.lastname: Mitra
authors.forename: B T
authors.initials: BT
authors.lastname: Flores
authors.forename: F E
authors.initials: FE
authors.lastname: Marchlinski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017180:Tachycardia, Ventricular / Q000628:therapy; D013908:Thoracotomy; D014693:Ventricular Fibrillation / Q000503:physiopathology*