title: The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. V. Minor metabolites.
abstract: The isolation and structure determination of 3H and 13C NMR and MS of 24 novel squalestatins from cultures of Phoma sp. C2932 is described.
authors.affiliation: Department of Natural Products Discovery, Glaxo Research and Development Ltd., Greenford, Middlesex, United Kingdom.
authors.forename: W M
authors.initials: WM
authors.lastname: Blows
authors.forename: G
authors.initials: G
authors.lastname: Foster
authors.forename: S J
authors.initials: SJ
authors.lastname: Lane
authors.forename: D
authors.initials: D
authors.lastname: Noble
authors.forename: J E
authors.initials: JE
authors.lastname: Piercey
authors.forename: P J
authors.initials: PJ
authors.lastname: Sidebottom
authors.forename: G
authors.initials: G
authors.lastname: Webb
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D014233:Tricarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D001643:Bridged Bicyclo Compounds; D014233:Tricarboxylic Acids; D013186:Farnesyl-Diphosphate Farnesyltransferase