title: Evaluation of cardiovascular risk factors in overweight and obese subjects.
abstract: Twenty obese subjects (Males = 8, Females = 12; average age = 39.5 +/- 2.5 years; B.M.I. = 36.2 +/- 2.5), 20 overweight subjects (Males = 8, Females = 12; average age = 38.5 +/- 2 years; B.M.I. = 28.8 +/- 0.4) and 20 non obese healthy subjects as controls, matched for sex and age (Males = 8, Females = 12; average age = 37.5 +/- 2 years; B.M.I. = 22.4 +/- 0.8) were selected. We determined: blood glucose, triglycerides, total cholesterol, HDL-cholesterol, Apolipoproteins A1 and B, Factor VII, fibrinogen and plasminogen. Before and after a venous occlusion test were also measured: t-PA Antigen, PAI activity and haematocrit. Metabolic, coagulative and fibrinolytic pathological changes were observed in overweight and obese subjects and the interaction of these risk factors may contribute to the pathogenesis of atherosclerosis vascular disease and to the high rate of thromboembolic events reported in obesity.
authors.affiliation: Institute of Clinical Medicine, University of Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Avellone
authors.forename: V
authors.initials: V
authors.lastname: Di Garbo
authors.forename: R
authors.initials: R
authors.lastname: Cordova
authors.forename: G
authors.initials: G
authors.lastname: Cucinella
authors.forename: R
authors.initials: R
authors.lastname: De Simone
authors.forename: G
authors.initials: G
authors.lastname: Raneli
authors.forename: G
authors.initials: G
authors.lastname: Bompiani
mesh_terms: D000328:Adult; D000886:Anthropometry; D016632:Apolipoprotein A-I / Q000032:analysis; D001055:Apolipoproteins B / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005167:Factor VII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications*; D010958:Plasminogen / Q000032:analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D005167:Factor VII; D005340:Fibrinogen; D010958:Plasminogen; D002784:Cholesterol