title: Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction.
abstract: In a European study an insertion (I)/deletion (D) polymorphism in the angiotensin converting enzyme (ACE) gene has been shown to be associated with the risk of myocardial infarction (MI). In the same study, we investigated the association of the polymorphism with a parental history of fatal MI. There was an excess of both DD (odds ratio 2.6, p = 0.02) and ID (odds ratio = 1.9, p = 0.08) genotypes among those having a parental history of MI, confirming that genetic variation in the ACE locus could be involved in the risk of MI.
authors.affiliation: INSERM U258, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Tiret
authors.forename: F
authors.initials: F
authors.lastname: Kee
authors.forename: O
authors.initials: O
authors.lastname: Poirier
authors.forename: V
authors.initials: V
authors.lastname: Nicaud
authors.forename: L
authors.initials: L
authors.lastname: Lecerf
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: J P
authors.initials: JP
authors.lastname: Cambou
authors.forename: D
authors.initials: D
authors.lastname: Arveiler
authors.forename: G
authors.initials: G
authors.lastname: Luc
authors.forename: P
authors.initials: P
authors.lastname: Amouyel
mesh_terms: D000328:Adult; D005260:Female; D005602:France; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality; D009660:Northern Ireland; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D007703:Peptidyl-Dipeptidase A