Tosyl arginine methyl ester induces bronchoconstriction in rabbit bronchial tissues in vitro: a possible new mediator in asthma.
Tosyl arginine methyl ester induced bronchoconstriction in rabbit bronchial rings mounted in vitro with a calculated EC50 of 5.6 x 10(-5) M as compared with acetylcholine which induced sustainable constriction with an EC50 of 2.5 x 10(-6) M. Tosyl arginine methyl ester, however, had definite bronchoconstricting properties though less potent than acetylcholine. We concluded that our data support the hypothesis that tosyl arginine methyl ester could be a possible biochemical mediator of airway contraction.
Subratty
A H
AH
SSR Centre for Medical Studies and Research, Faculty of Science, University of Mauritius, Moka.
Kok-Shun
L H
LH
Yan
M Y
MY
Fakim
N
N
D000109:Acetylcholine / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001980:Bronchi / Q000187:drug effects / Q000502:physiology*; D016084:Bronchoconstriction / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D011817:Rabbits; D014106:Tosylarginine Methyl Ester / Q000009:adverse effects / Q000494:pharmacology*
D014106:Tosylarginine Methyl Ester; D000109:Acetylcholine