Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.
We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.
Roth
M
M
Department of Research, University Hospital Basel, Switzerland.
Rogers
S
S
Roberts
S S
SS
Boyle
J M
JM
Müller
H J
HJ
Weber
W
W
D000477:Alkylating Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D014466:Ultraviolet Rays
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D004247:DNA