title: Astrocytoma with a unique telomere association.
abstract: Many primary pediatric brain tumors are characterized by nonrandom cytogenetic abnormalities involving specific structural rearrangements and loss or gain of specific chromosomes. We describe a low-grade cerebellar astrocytoma with telomeric association of chromosomes 18 and 21 in a 7-year old girl. The nonrandom telomeric association of these chromosomes represents a unique cytogenetic finding in this type of pediatric brain tumor.
authors.affiliation: Cytogenetics/Embryopathology Laboratory, British Columbia Children's Hospital, Vancouver.
authors.forename: K J
authors.initials: KJ
authors.lastname: Harrison
authors.forename: E
authors.initials: E
authors.lastname: Neumann
authors.forename: D K
authors.initials: DK
authors.lastname: Kalousek
authors.forename: M G
authors.initials: MG
authors.lastname: Norman
authors.forename: S
authors.initials: S
authors.lastname: Masui
authors.forename: K
authors.initials: K
authors.lastname: Harrison
mesh_terms: D001254:Astrocytoma / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D016615:Telomere