title: Decrease in normal human corneal sensitivity with topical diclofenac sodium.
abstract: We tested the effect of topical diclofenac sodium on corneal sensitivity in the human eye. Corneal sensitivity was measured in ten adult subjects with the Cochet-Bonnet esthesiometer before, and immediately after, applying one drop of diclofenac sodium 0.1% in one eye and one drop of diclofenac vehicle in the other eye. Application was repeated every five minutes for 20 minutes; then no more drops were applied, and corneal sensitivity was measured every 15 minutes until sensitivity measurements returned to baseline levels. Diclofenac sodium decreased corneal sensitivity significantly (P = .0001) in all ten subjects, compared with eyes treated with the vehicle. The effect of diclofenac sodium increased as additional drops were administered. After the drug instillation was stopped, corneal sensitivity returned to baseline measurements within less than an hour in all the subjects. Diclofenac sodium substantially lowers sensitivity in normal, unoperated-on human corneas; the vehicle has no measurable effect on sensitivity.
authors.affiliation: Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: K
authors.initials: K
authors.lastname: Szerenyi
authors.forename: K
authors.initials: K
authors.lastname: Sorken
authors.forename: J J
authors.initials: JJ
authors.lastname: Garbus
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: P J
authors.initials: PJ
authors.lastname: McDonnell
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D003315:Cornea / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D004008:Diclofenac / Q000494:pharmacology*; D006801:Humans; D009883:Ophthalmic Solutions; D009885:Ophthalmology / Q000295:instrumentation; D014276:Trigeminal Nerve / Q000502:physiology
chemical_list: D009883:Ophthalmic Solutions; D004008:Diclofenac