Recurrence of Wegener's granulomatosis following renal transplantation.
A 43-yr-old man with a 19-yr history of Wegener's granulomatosis presented with recurrent haematuria, pulmonary infiltrate, cutaneous vasculitis, nasal mucosal involvement and elevation of ANCA levels, 2 yr following successful cadaveric renal transplantation, despite continued immunosuppressive therapy with cyclosporine, azathioprine and prednisone. Re-introduction of cyclophosphamide therapy resulted in prompt resolution of clinical and laboratory abnormalities. The superiority of cyclophosphamide over cyclosporine for maintaining suppression of Wegener's granulomatosis is substantiated in a critical review of the literature.
Rosenstein
E D
ED
Division of Nephrology, Neward Beth Israel Medical Center, NJ.
Ribot
S
S
Ventresca
E
E
Kramer
N
N
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012008:Recurrence
D003520:Cyclophosphamide