title: Coupling of cell structure to cell metabolism and function.
abstract: The fact that cells make directed decisions regarding how to use energy, i.e., where to direct intracellular particles or where to move, suggests that energy can be, and is, harnessed in specific ways. It is now well established that the chemical reactions of the cell do not occur in nonorganized soup, but rather in the context of ordered structure. The physical components that make up this ordered structure of the cell are part of the tissue matrix, which consists of the dynamic linkages between the skeletal networks of the nucleus (the nuclear matrix), the cytoplasm (the cytoskeleton), and the extracellular environment (the extracellular matrix). To understand gene function and how the energy of the cell is directed towards accomplishing the tasks directed by DNA (gene expression), a further understanding of how cell structure is tied to cellular energy and function is required. We propose that the structural components of the cell harness cellular energy to direct cell functions by providing a dynamic bridge between thermodynamics and gene expression.
authors.affiliation: Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201.
authors.forename: K J
authors.initials: KJ
authors.lastname: Pienta
authors.forename: C N
authors.initials: CN
authors.lastname: Hoover
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D002477:Cells / Q000378:metabolism / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D015530:Nuclear Matrix / Q000502:physiology / Q000648:ultrastructure; D013329:Structure-Activity Relationship; D013816:Thermodynamics