Diabetes disrupts copulatory behavior and neuroendocrine responses of male rats to female conspecifics.
Streptozotocin-induced diabetes disrupts copulatory behavior in the male rat. The increase in serum luteinizing hormone (LH) that occurs in the male rat in response to the presence of a receptive female is absent in most diabetic rats. A female-induced testosterone rise is not seen in diabetic male rats, including those showing an increase in LH. The female-induced LH rise appears to be secondary to increased hypothalamic norepinephrine metabolism, which is severely attenuated in diabetic rats not exhibiting an LH rise in response to a female.
Hails
R
R
Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901.
Fadden
C
C
Steger
R W
RW
D000818:Animals; D003307:Copulation / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000523:psychology*; D005260:Female; D007033:Hypothalamus, Middle / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008473:Median Eminence / Q000378:metabolism; D009490:Neurosecretory Systems / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood
D018377:Neurotransmitter Agents; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D009638:Norepinephrine