The neuropsychiatry of brain iron.
In the last two decades, many biological functions of iron have been identified, in particular its role in many enzymatic processes, its effect on dopamine D2 receptor function, its interaction with other neurotransmitters (gamma-aminobutyric acid, serotonin, opiate-peptides), and its catalytic role in the nonenzymatic mechanisms for oxidation, hydroxylation, and peroxidation reactions. The role of iron in Parkinson's disease, Alzheimer's disease, brain injury due to exogenous causes, neuroleptic-induced movement disorders, schizophrenia, and other neuropsychiatric disorders is currently being explored. This study summarizes current understanding of the anatomy and physiology of brain iron with special reference to these disorders.
Sachdev
P
P
School of Psychiatry, University of New South Wales, Australia.
D000544:Alzheimer Disease / Q000378:metabolism; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001923:Brain Chemistry; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000188:drug therapy; D010300:Parkinson Disease / Q000378:metabolism*; D011859:Radiography; D012559:Schizophrenia / Q000378:metabolism
D014150:Antipsychotic Agents; D007501:Iron