Influence of glucocorticoids and activated charcoal on the lethality of rats after acute poisoning with T-2 toxin, diacetoxyscirpenol, or roridin A.
Lethal doses of the trichothecene mycotoxins T-2 toxin (1.5 mg/kg), diacetoxyscirpenol (DAS; 2.3 mg/kg) or roridin A (1.3 mg/kg) were intravenously administered to rats. When rats were treated with either activated charcoal (Superchar liquid, Norit A; 1 g/kg, po) or dexamethasone (8 mg/kg, iv) 30 min after poisoning with one of the trichothecenes, lethality was only marginally reduced. However, when the combination of activated charcoal (Superchar liquid or Norit A) and dexamethasone was administered, the survival rate of animals after 30 days was significantly enhanced by up to 50%. Comparison between 2 preparations of activated charcoal, Norit AR with a surface area of 1,000 m2/g and Superchar liquidR with a surface area of 3,000 m2/g, each in combination with dexamethasone, revealed no difference in their therapeutic efficacy. Prednisolone (60 mg/kg) was as effective as dexamethasone (8 mg/kg), each administered with activated charcoal, in preventing death in acute T-2 toxicosis.
Hunder
G
G
Walther Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Germany.
Fichtl
B
B
Forth
W
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000506:poisoning; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000506:poisoning; D002606:Charcoal / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D007275:Injections, Intravenous; D008297:Male; D011041:Poisoning / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013605:T-2 Toxin / Q000008:administration & dosage / Q000506:poisoning; D014255:Trichothecenes / Q000008:administration & dosage / Q000506:poisoning*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D014255:Trichothecenes; D002606:Charcoal; D003907:Dexamethasone; D011239:Prednisolone; D013605:T-2 Toxin; C038849:roridin A; C001809:diacetoxyscirpenol