title: CNQX infused into rat hippocampus or amygdala disrupts the expression of memory of two different tasks.
abstract: The bilateral infusion of CNQX (0.5 or 1.25 micrograms) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocked the expression of stepdown inhibitory avoidance in rats 24 h after training. When infused into both the amygdala and the hippocampus at a dose of 0.5 microgram. CNQX caused a complete blockade of the expression of that task. Retention test performance recovered 2 h after the infusions. In rats trained for habituation to a novel environment and tested 24 h later, pretest intrahippocampal CNQX (0.5 microgram) blocked the expression of retention at a dose of 0.5 microgram, and intra-amygdala CNQX (0.5 or 1.25 micrograms) had no effect. The data suggest that, up to at least 1 day after training, memory of the avoidance task depends on glutamate acting on non-NMDA receptors in both the hippocampus and the amygdala, whereas memory of the habituation task depends on non-NMDA receptor activity in the hippocampus but not the amygdala.
authors.affiliation: Departamento de Bioquimica, Instituto de Biociencias, U.F.R.G.S., Porto Alegre, RS, Brazil.
authors.forename: I
authors.initials: I
authors.lastname: Izquierdo
authors.forename: M
authors.initials: M
authors.lastname: Bianchin
authors.forename: M B
authors.initials: MB
authors.lastname: Silva
authors.forename: M S
authors.initials: MS
authors.lastname: Zanatta
authors.forename: R
authors.initials: R
authors.lastname: Walz
authors.forename: A C
authors.initials: AC
authors.lastname: Ruschel
authors.forename: R C
authors.initials: RC
authors.lastname: Da Silva
authors.forename: N
authors.initials: N
authors.lastname: Paczko
authors.forename: J H
authors.initials: JH
authors.lastname: Medina
mesh_terms: D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D004357:Drug Synergism; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D011810:Quinoxalines / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
chemical_list: D011810:Quinoxalines; D016194:Receptors, N-Methyl-D-Aspartate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione