title: Effects of dietary acidity on calcium balance and mobilisation, bone morphology and 1,25 dihydroxyvitamin D in prepartal dairy cows.
abstract: The effect of an acid or alkali diet was investigated in 14 mature dairy cows during the last 28 days of pregnancy. The acid diet reduced the incidence of parturient hypocalcaemia compared with the alkali diet and was associated with higher blood ionised calcium and plasma chloride concentrations and lower blood pH and acid-base excess before parturition. Plasma 1,25-dihydroxyvitamin D concentrations before parturition were increased by the acid diet but the concentrations of parathyroid hormone and intact 1-86 parathyroid-hormone-related peptide were unaffected. The estimated fractional calcium absorption and calcium mobilisation rate during an ethylenediamine tetraacetic acid infusion were increased by the acid diet 14 days before parturition. Cortical bone remodelling occurred in all the animals during late pregnancy but was particularly evident in the cows given the acid diet. The data suggest that an acid diet ameliorates parturient hypocalcaemia by enhancing calcium mobilisation before parturition by increasing calcium absorption and bone resorption, these increases possibly being mediated by increases in the plasma concentration of 1,25-dihydroxyvitamin D.
authors.affiliation: Rowett Research Institute, Bucksburn, Aberdeen.
authors.forename: H
authors.initials: H
authors.lastname: Abu Damir
authors.forename: M
authors.initials: M
authors.lastname: Phillippo
authors.forename: B H
authors.initials: BH
authors.lastname: Thorp
authors.forename: J S
authors.initials: JS
authors.lastname: Milne
authors.forename: L
authors.initials: L
authors.lastname: Dick
authors.forename: I M
authors.initials: IM
authors.lastname: Nevison
mesh_terms: D000821:Animal Feed; D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000166:cytology*; D002113:Calcification, Physiologic; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002417:Cattle; D002712:Chlorides / Q000097:blood; D004032:Diet; D005260:Female; D006863:Hydrogen-Ion Concentration; D007743:Labor, Obstetric / Q000097:blood*; D008274:Magnesium / Q000097:blood; D010710:Phosphates / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*
chemical_list: D002712:Chlorides; D010710:Phosphates; D002117:Calcitriol; D008274:Magnesium; D002118:Calcium