title: Ascorbic acid increases synaptosomal potassium-induced dopamine release.
abstract: On synaptosomes prepared from striata of mice, increasing concentrations of ascorbic acid (from 0.01 mM to 0.5 mM) did not modify the 3H-dopamine uptake. However, at the 0.1 mM concentration, ascorbic acid increased the potassium-induced release of 3H-dopamine by synaptosomes previously loaded with the amine. This effect was dependent on the presence of Ca2+ in the superfusion medium and was not shared by dehydroascorbic acid (from 1 mM to 0.01 mM). This effect of ascorbic acid, which occurs in the range of its endogenous concentrations, suggests that it is a putative modulator of dopaminergic transmission.
authors.affiliation: Unité de Neuropsychopharmacologie, CNRS URA 1170, Faculté de Médecine et Pharmacie de Rouen, Saint-Etienne du Rouvray, France.
authors.forename: F
authors.initials: F
authors.lastname: Girbe
authors.forename: C
authors.initials: C
authors.lastname: Ramassamy
authors.forename: C
authors.initials: C
authors.lastname: Piton
authors.forename: J
authors.initials: J
authors.lastname: Costentin
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003683:Dehydroascorbic Acid / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
chemical_list: D001205:Ascorbic Acid; D011188:Potassium; D004298:Dopamine; D003683:Dehydroascorbic Acid