[Androgens and the brain].
Recent years investigations provided, that androgens belong to the group of neurosteroids synthetized and metabolized in the brain tissue by both: the cells (neurons and glia) and the white matter. Two basal metabolic pathways of androgens: aromatisation and 5-alpha-reduction probably serve different physiological functions in different life periods. During the fetal life are the crucial processes for the organisation of the brain centers toward male patterns. At latter stages might play an important role in the feedback mechanisms controlling LH secretion. The action of neurosteroids is mediated by classic nuclear receptors, but also by cell-membrane receptors, and this effect is rapid and specific. Androgens can also modulate the action of others neurotransmitters by binding to their cell-membrane receptors, eg. GABA-A.
Kleinrok
Z
Z
Zakładu Farmakologii AM, Lublinie.
Sieklucka-Dziuba
M
M
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005246:Feedback / Q000502:physiology; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism; D012016:Reference Values
D000728:Androgens; D011944:Receptors, Androgen
Androgeny a mózg.