title: Chlorambucil for platinum-refractory ovarian cancer.
abstract: Chlorambucil is frequently given to patients with platinum refractory ovarian cancer, particularly if they are thought to have end-stage disease. We have examined the case records of 25 patients who have been treated in this way. No patient had an objective or subjective response. Chlorambucil is ineffective in platinum-refractory epithelial ovarian cancer.
authors.affiliation: Gynaecology Unit, Royal Marsden Hospital, London, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Taylor
authors.forename: M E
authors.initials: ME
authors.lastname: Gore
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy; D002699:Chlorambucil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D010984:Platinum / Q000627:therapeutic use*; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D002699:Chlorambucil; D010984:Platinum