title: Combined intracerebral microdialysis and electrophysiological recording: methodology and applications.
abstract: A microdialysis probe is described that can simultaneously monitor indices of electrical activity, ionic homeostasis and changes in the composition of the extracellular fluid at the same brain site in anaesthetised laboratory animals. The probe is no larger than its conventional counterpart and avoids tissue injury problems due to implantation of separate recording electrodes. Examples are given of its application to the study of changes following probe implantation, cerebral ischaemia and local high K(+)-induced depolarisation.
authors.affiliation: Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, UK.
authors.forename: T P
authors.initials: TP
authors.lastname: Obrenovitch
authors.forename: D A
authors.initials: DA
authors.lastname: Richards
authors.forename: G S
authors.initials: GS
authors.lastname: Sarna
authors.forename: L
authors.initials: L
authors.lastname: Symon
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000768:Anesthesia, General; D000818:Animals; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D002118:Calcium / Q000502:physiology; D003956:Dialysis / Q000379:methods*; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D005971:Glutamates / Q000032:analysis*; D018698:Glutamic Acid; D008297:Male; D008832:Microchemistry / Q000379:methods*; D008839:Microelectrodes; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D011188:Potassium; D002118:Calcium