Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.
Woodburn
K W
KW
Department of Biochemistry, La Trobe University, Bundoora, Australia.
Hill
J S
JS
Stylli
S
S
Kaye
A H
AH
Reiss
J A
JA
Phillips
D R
DR
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017324:Hematoporphyrin Derivative / Q000494:pharmacology; D006414:Hematoporphyrin Photoradiation; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar
D017324:Hematoporphyrin Derivative