title: Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.
abstract: We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
authors.affiliation: Service de Médecine Interne et d'Immunologie Clinique, CHU Jean Minjoz, Besançon, France.
authors.forename: T
authors.initials: T
authors.lastname: Fest
authors.forename: B
authors.initials: B
authors.lastname: de Wazières
authors.forename: B
authors.initials: B
authors.lastname: Lamy
authors.forename: M
authors.initials: M
authors.lastname: Maskani
authors.forename: D
authors.initials: D
authors.lastname: Vuitton
authors.forename: J L
authors.initials: JL
authors.lastname: Dupond
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology / Q000628:therapy*; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006384:Hemagglutination; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D011994:Recombinant Proteins
chemical_list: D001323:Autoantibodies; D006454:Hemoglobins; D007075:Immunoglobulin M; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins