Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.
The Min (multiple intestinal neoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for the Min mutation. Min, a mutant allele of Apc, the mouse homolog of the human APC (adenomatous polyposis coli) gene, maps to proximal chromosome 18. The synteny between Apc and Mcc, the mouse homolog of the human MCC (mutated in colorectal cancer) gene, is conserved between mouse and human, although the gene order in the Apc to Mcc interval is different from that in the APC to MCC interval.
Luongo
C
C
McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706.
Gould
K A
KA
Su
L K
LK
Kinzler
K W
KW
Vogelstein
B
B
Dietrich
W
W
Lander
E S
ES
Moser
A R
AR
D000236:Adenoma / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004277:DNA, Single-Stranded; D005260:Female; D007414:Intestinal Neoplasms / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D004277:DNA, Single-Stranded