title: Blood lipid changes in hypertensive, dyslipidemic patients under long term quinapril treatment.
abstract: OBJECTIVE
  The present study aimed at verifying Quinapril effects on both pressure and lipid profile in 15 patients (5 M, 10 F), aged 45 to 80 years (63 +/- 9), complaining for mild to moderate hypertension and dyslipidemia (total cholesterol > 200 mg/dl and triglycerides > 200 mg/dl). No relevant associated disease was present, including diabetes mellitus not any lipid lowering drugs were given.
  
  
  METHODS
  After a wash-out period of one week, all patients, who had been hypertensive for 2 to 120 months (33 +/- 11), were given Quinapril 20 mg orally once a day for 6 months and kept on a low lipid diet from before treatment to the end of the study. Lipid profile we assessed at three-month intervals.
  
  
  RESULTS
  Blood pressure, monitored at two-week intervals, significantly decreased on the 1st month (p < 0.001), and kept lower thereafter. Mean total cholesterol, triglycerides and low density lipoprotein cholesterol levels, after 6 months of therapy, were reduced by 44 mg/dl (p < 0.001), 29 mg/dl (p < 0.001) and 39 mg/dl (p < 0.002) respectively.
  
  
  CONCLUSIONS
  Our results seen indicate that Quinapril antihypertensive effects are accompanied by a significant improvement of the lipid profile.
authors.affiliation: Unità Operativa Cardiologica, INRCA, National Institute of Research, Rome, Italy.
authors.forename: M M
authors.initials: MM
authors.lastname: Cangelosi
authors.forename: M
authors.initials: M
authors.lastname: Gaudio
authors.forename: A M
authors.initials: AM
authors.lastname: Brancati
authors.forename: F
authors.initials: F
authors.lastname: Leggio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D007546:Isoquinolines / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D007546:Isoquinolines; D008055:Lipids; D008077:Lipoproteins, LDL; D044005:Tetrahydroisoquinolines; D014280:Triglycerides; D002784:Cholesterol; D000077583:Quinapril