title: Prevalence and duration of hot flushes after surgical or medical castration in men with prostatic carcinoma.
abstract: A total of 77 men with prostatic carcinoma treated with orchiectomy or a gonadotropin releasing hormone analogue before September 1987 underwent evaluation by a questionnaire regarding vasomotor symptoms. Answers were received from 84% of the patients. Of 63 patients 43 (68%) reported hot flushes during treatment, while 30 (48%) still had flushes 5 years after treatment. Of the latter 30 patients 28 (median 7.6 years after treatment) had vasomotor symptoms at the time of the study. Only 13 of 43 men with vasomotor symptoms after the start of treatment had relief 5 years later. At the time of the study 13 of 30 patients (more than 40%) still had flushes 8 years after castration. Most men reported that the flushes presently had the same frequency and duration as when they started therapy. Contrary to the general belief that the symptoms disappear with time, our study highlighted a long persistence of hot flushes after castration.
authors.affiliation: Department of Obstetrics and Gynecology, University of Health Sciences, Linköping, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Karling
authors.forename: M
authors.initials: M
authors.lastname: Hammar
authors.forename: E
authors.initials: E
authors.lastname: Varenhorst
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D002979:Climacteric; D017273:Goserelin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000628:therapy*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D000726:Androgen Antagonists; D017273:Goserelin