The effect of (-)-4-(2-hydroxy-3(N-isopropylamino)-propoxyimino)-cis-carane on basal and forskolin-stimulated accumulation of cyclic AMP in the cerebral cortical slices of the rat.
(-)-4-(2-Hydroxy-3(N-isopropylamino)-propoxyimino)-cis-carane++ +, a local anaesthetic and platelet aggregation inhibitor which is much more potent than lignocaine, facilitated forskolin-induced cyclic (c) AMP accumulation in cerebral cortical slices of the rat. Lignocaine was ineffective in this respect. It is hypothesized that a cAMP-related mechanism may be involved in increased efficacy of the compound.
Librowski
T
T
Department of Pharmacodynamics, Copernicus Medical Academy, Kraków, Poland.
Nalepa
I
I
Czarnecki
R
R
Vetulani
J
J
D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000081008:Bicyclic Monoterpenes; D002540:Cerebral Cortex / Q000187:drug effects*; D005576:Colforsin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D003514:Cyclohexylamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015290:Second Messenger Systems / Q000187:drug effects
D000779:Anesthetics, Local; D000081008:Bicyclic Monoterpenes; D003514:Cyclohexylamines; D010975:Platelet Aggregation Inhibitors; C079300:4-(2-hydroxy-3-(N-isopropylamino)propoxyimino)carane; D005576:Colforsin; D008012:Lidocaine; D000242:Cyclic AMP