High incidence of gastrointestinal cancer in a family with ataxia-telangiectasia.
Literature suggests that not only homozygotes but also heterozygotes for ataxia-telangiectasia have a high incidence of cancer, probably due to an impairment in DNA repair. The most frequent associations are with breast, lung, bladder, prostate and stomach tumors, while no correlation with colorectal cancer has been demonstrated. The affected family reported in this paper seems to have a high incidence of gastrointestinal tract tumors, including the colorectal ones.
Ceroni
M
M
Neurological Institute, IRCCS C. Mondino Foundation, University of Pavia, Italy.
Karau
J
J
Pergami
P
P
Ferrandi
D
D
Savoldi
F
F
D000328:Adult; D001260:Ataxia Telangiectasia / Q000150:complications* / Q000235:genetics*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004200:Diseases in Twins / Q000235:genetics; D005192:Family Health; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000453:epidemiology; D005796:Genes / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D008297:Male; D010375:Pedigree; D014429:Twins, Dizygotic / Q000235:genetics