Central catheter infection by Trichosporon beigelii after autologous blood stem cell transplantation. A case report and review of the literature.
A case of localized Trichosporon beigelii infection is reported in a 40-year-old woman with Ph+ chronic granulocyte leukemia who underwent autologous blood stem cell transplantation. On day +14 after autograft, while severely neutropenic, she developed a local infection involving the soft tissues surrounding the central venous catheter (CVC) point of entry into the subclavian vein. Trichosporon beigelii was isolated from culture of the CVC tip; resolution occurred after removal of the CVC, neutrophil recovery and antifungal treatment with amphotericin B and 5-fluorocytosine. To our knowledge this is the first case of CVC localized infection from Trichosporon beigelii after transplantation.
Vasta
S
S
Dipartimento di Ematologia, Ospedale V. Cervello, Palermo, Italy.
Menozzi
M
M
Scimé
R
R
Indovina
A
A
Speciale
A
A
Liberti
G
G
Spanò
C
C
Majolino
I
I
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001804:Blood Transfusion, Autologous; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy; D015465:Leukemia, Myeloid, Accelerated Phase / Q000150:complications / Q000628:therapy; D009181:Mycoses / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D014250:Trichosporon / Q000302:isolation & purification*
D000935:Antifungal Agents