[Effect of nitrendipine on hypoxic myocardial energy preservation].
To investigate the relationship between post-hypoxic myocardial dysfunction and myocardial energy reserve and the effect of nitrendipine on hypoxic myocardial energy preservation, we submitted the Langendorff isolated perfused rat hearts to 30 minutes of hypoxia and then 20 minutes of reoxygenation. Nitrendipine was infused continuously 10 minutes before hypoxia and throughout the following perfusion. The high energy phosphate contents of isolated perfused rat hearts before and 30 minutes after hypoxia were measured by using reverse high performance liquid chromatography. The results showed that nitrendipine, when administered prophylactically, enhanced myocardial energy reserve and relieved high energy phosphates' depletion during 30 minutes of hypoxia insult. It is suggested that nitrendipine has an effect on hypoxic myocardial energy preservation.
Zheng
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Lan
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D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D015687:Cell Hypoxia; D003401:Creatine / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009568:Nitrendipine / Q000494:pharmacology*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D010725:Phosphocreatine; D009568:Nitrendipine; D003401:Creatine