title: Purified antichick Thy-1 IgG abolishes intermediate and long-term memory.
abstract: One- to 2-day-old chicks administered purified antichick Thy-1 IgG showed substantial amnesia for a single-trial passive discriminated avoidance task. Amnesia was clearly evident at 30 min after learning, during the intermediate stage of a three-stage model of memory processing, and persisted for at least 3 h. A similar effect was also observed with Fab and F(ab')2 fragments. Fc fragments, the non-IgG fraction of ascites, and saline yielded normal retention levels at all times. These results contrast with our earlier reports that both polyclonal and monoclonal antibodies to chick Thy-1 inhibited long-term memory formation only. The present findings are interpreted as possibly representing a dual effect of the purified IgG.
authors.affiliation: Department of Psychology, La Trobe University, Bundoora, Vic. Australia.
authors.forename: H
authors.initials: H
authors.lastname: Feng
authors.forename: W Q
authors.initials: WQ
authors.lastname: Zhao
authors.forename: C C
authors.initials: CC
authors.lastname: Bernard
authors.forename: K T
authors.initials: KT
authors.lastname: Ng
authors.forename: G
authors.initials: G
authors.lastname: Sedman
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000954:Antigens, Surface / Q000276:immunology / Q000502:physiology*; D001202:Ascitic Fluid / Q000276:immunology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000276:immunology / Q000502:physiology; D002645:Chickens; D003118:Color Perception / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D007074:Immunoglobulin G / Q000494:pharmacology*; D007518:Isoantibodies / Q000494:pharmacology*; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology*; D013570:Synaptic Membranes / Q000276:immunology / Q000502:physiology; D013649:Taste / Q000187:drug effects / Q000502:physiology; D018800:Thy-1 Antigens
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007074:Immunoglobulin G; D007518:Isoantibodies; D008562:Membrane Glycoproteins; D018800:Thy-1 Antigens; C035678:anti-Thy antibody