[Effects of fentanyl on renal sympathetic nerve activity, heart rate and systemic blood pressure in anesthetized rabbits--an evaluation in both rabbits and human].
This study was designed to evaluate effects of fentanyl (F) on heart rate (HR), systemic blood pressure (SBP) and renal sympathetic nerve activity (RNA) in urethane- or halothane-anesthetized rabbits. Twenty three urethane-anesthetized rabbits were divided into the following four groups: animals with neuraxis intact (Intact group, N = 8), cervical vagotomized animals (Vagotomy group, N = 5), animals treated with sino-aortic denervation (SAD group, N = 5), and those with sino-aortic denervation with vagotomy (SADV group, N = 5). In the intact group, administration of F (20 micrograms.kg-1, i.v.) caused a significant decrease in HR, but not in SBP, even in the presence of increase in RNA. In the Vagotomy group, no significant alterations in HR and SBP occurred despite activation of RNA. In the SAD group, F caused a significant decrease in HR and an increase in both SBP and RNA. In the SADV group, a decrease in HR disappeared but a significant increase in both SBP and RNA developed. In halothane-anesthetized rabbits having intact baroreceptors (N = 5), similar hemodynamic and sympathetic responses to F were observed. In human (N = 5), F (6 micrograms.kg-1, i.v.) caused a decrease in HR but the effect was not significant on SBP. Thus similar hemodynamic changes occurred in both human and in the animals. These results suggest that F may cause a simultaneous activation of vagal nerve and sympathetic nervous system, which might contribute to the hemodynamic stability when F is administered in human.
Honda
K
K
Department of Anesthesiology and Emergency Medicine, Kagawa Medical School.
Aibiki
M
M
Ogura
S
S
Umegaki
O
O
D000328:Adult; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000294:innervation*; D008297:Male; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D014520:Urethane; D014628:Vagotomy
D014520:Urethane; D005283:Fentanyl; D006221:Halothane