Radiation-induced angiosarcoma of the breast. Case report and review of the literature.
Angiosarcoma is a rare, highly malignant soft tissue sarcoma that sometimes occurs in the breast as a late sequela of treatment for breast cancer. The conventional treatment for radiation-induced angiosarcoma is surgery, which is associated with a poor overall prognosis. We report a case of radiation-induced angiosarcoma of the intact breast that occurred 6 years after breast conservation therapy. Simple mastectomy was performed; however, rapid chest wall recurrence of angiosarcoma ensued. After salvage therapy with combined radiotherapy and hyperthermia, the patient has been disease-free for more than 3 years.
Buatti
J M
JM
Department of Radiation Oncology, University of Florida Health Science Center, Gainesville 32610-0385.
Harari
P M
PM
Leigh
B R
BR
Cassady
J R
JR
D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006979:Hyperthermia, Induced; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects