[The therapeutic and prophylactic effect of 4-iodoantipyrine in experimental tick-borne encephalitis].
The antiviral activity of iodantipyrine-4 belonging to the group of nonsteroid anti-inflammatory compounds was studied in inbred white mice of 10-12 g given a single subcutaneous injection of the Absettarov strain of tick-borne encephalitis virus. Iodantipyrine-4 in different doses was administered orally or parenterally, and the animals were observed for 21 days. In the group of mice infected with 10 LD50 of TBE virus which were treated with the drug orally in a dose of 50 mg/kg a reliable therapeutic effect was established in 60%, after parenteral injection in 53.4%. Prophylactic administration of the drug followed by challenge with 10 LD50 of virus was effective in 47% of mice. In the group of mice infected with 100 LD50 of the virus the therapeutic effect was observed in 38% and prophylactic in 30%. Iodantipyrine-4 was found to induce interferon production.
Iavorovskaia
V E
VE
Saratikov
A S
AS
Fedorov
Iu V
IuV
Evstropov
A N
AN
Solianik
R G
RG
Anosova
G V
GV
Prishchep
T P
TP
Gritsenko
L N
LN
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004176:Dipyridamole / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use; D016898:Interferon-alpha / Q000097:blood; D008297:Male; D051379:Mice
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D007369:Interferon Inducers; D016898:Interferon-alpha; D004176:Dipyridamole; D000983:Antipyrine; C008135:iodoantipyrine
Lechebnyĭ i profilakticheskiĭ éffekt 4-ĭodantipirana pri éksperimental'nom kleshchevom éntsefalite.