[Electrophysiological studies in patients with familial myasthenia and health family members].
Three cases are presented of familial myasthenia gravis: two sisters and their cousin. Healthy members of this family were also examined. Myasthenia gravis was diagnosed on the ground of the clinical and electrophysiological examination (decrement test and SF EMG with jitter evaluation) as well as of the immunological tests (anti AChR antibodies and HLA antigens B8, DR3). Several healthy relatives of myasthenic patients had HLA B8 and DR3 antigens and/or presented neuromuscular transmission disturbances detected on SF EMG examination. Occurrence of myasthenia in two or more members of a family can be a risk factor for the remaining members.
Owczarek
E
E
Kliniki Neurologicznej AM., Warszawie.
Emeryk-Szajewska
B
B
Strugalska-Cynowska
M
M
D000110:Acetylcholinesterase / Q000276:immunology; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D015795:HLA-B8 Antigen / Q000276:immunology; D015803:HLA-DR3 Antigen / Q000276:immunology; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000235:genetics*; D010375:Pedigree; D009435:Synaptic Transmission
D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000110:Acetylcholinesterase
Badania elektrofizjologiczne u chorych z rodzinna miastenia i zdrowych członków ich rodzin.