title: [CNS-active pyrans: amine- and aryl- substituted dioxabicyclooctanes].
abstract: The amin- and phenyl substituted 6,8-dioxabicyclooctanes 10 and 11 show distinct CNS-activities. Intensity and profile depend on the type of amine and the stereochemistry of the products. Therefore, we have synthesized 6,8-dioxabicyclooctanes with different amine-phenyl distances and examined their CNS-activities on mice as well as by receptor binding studies with the PCP-binding site which is part of the NMDA-receptor-complex.
authors.affiliation: Institut für Pharmazie und Lebensmittelchemie, Ludwig-Maximilians-Universität, München.
authors.forename: F
authors.initials: F
authors.lastname: Eiden
authors.forename: F
authors.initials: F
authors.lastname: Denk
authors.forename: G
authors.initials: G
authors.lastname: Höfner
mesh_terms: D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011869:Radioligand Assay; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D017478:Receptors, Phencyclidine / Q000187:drug effects
chemical_list: D001643:Bridged Bicyclo Compounds; D002491:Central Nervous System Agents; D016194:Receptors, N-Methyl-D-Aspartate; D017478:Receptors, Phencyclidine
vernacular_title: ZNS-wirksame Pyrane: Amin- und arylsubstituierte Dioxabicyclooctane.