Colorectal cancer in patients with X-linked agammaglobulinaemia.
Primary immunodeficiency disorders can predispose to certain malignancies but hitherto no such relation has been established for X-linked agammaglobulinaemia (XLA). We have diagnosed rapidly progressive colorectal cancer in 3 unrelated young adults with XLA. We could find no explanation for the tumours. Since the calculated incidence of rectosigmoid cancer is increased 30-fold in patients with XLA, we advise the screening of these individuals, and perhaps people with other agammaglobulinaemias, for colorectal cancer.
van der Meer
J W
JW
Department of General Internal Medicine, University Hospital Nijmegen, Netherlands.
Weening
R S
RS
Schellekens
P T
PT
van Munster
I P
IP
Nagengast
F M
FM
D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000150:complications*; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D014960:X Chromosome