The synthesis of trans-3,4-bis-(3,4-dihydroxyphenyl)pyrrolidine, a novel DA1 agonist.
The synthesis of trans-3,4-bis-(3,4-dihydroxyphenyl)pyrrolidine by the Michael reaction of esterenolate with nitro olefin is described. This compound was expected to be the agonist toward dopamine (DA1) receptor with equipotent affinity and to be more selective than dopamine itself.
Hoshiko
T
T
Eisai Tsukuba Research Laboratories, Ibaraki, Japan.
Ishihara
H
H
Shino
M
M
Mori
N
N
D000818:Animals; D002396:Catechols / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D015259:Dopamine Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D012079:Renal Circulation / Q000187:drug effects
D002396:Catechols; D015259:Dopamine Agents; D011759:Pyrrolidines; D017447:Receptors, Dopamine D1; C080923:3,4-bis(3,4-dihydroxyphenyl)pyrrolidine