Secretion of testosterone and epidermal growth factor in mice with oligozoospermia caused by doxorubicin hydrochloride.
Oligozoospermia was induced experimentally by treatment with doxorubicin hydrochloride, an anticancer drug, in mice. In the testes, almost all germ cells disappeared, but Leydig cells appeared to be unchanged. The secretion of testosterone and epidermal growth factor (EGF), both of which are involved in spermatogenesis, was not influenced by the treatment. These results suggest that doxorubicin hydrochloride does not act indirectly by affecting testosterone and EGF, but produces oligozoospermia by effecting directly germ cells.
Sawada
T
T
Department of Animal Reproduction, College of Agriculture, University of Osaka Prefecture, Japan.
Tamada
H
H
Mori
J
J
D000818:Animals; D000970:Antineoplastic Agents; D004317:Doxorubicin; D004815:Epidermal Growth Factor / Q000378:metabolism*; D008297:Male; D051379:Mice; D009845:Oligospermia / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D013076:Sperm Count; D013094:Spermatozoa / Q000473:pathology; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000378:metabolism*
D000970:Antineoplastic Agents; D013739:Testosterone; D004815:Epidermal Growth Factor; D004317:Doxorubicin