title: Treatment of hypotonous maculopathy after trabeculectomy with mitomycin C.
abstract: We treated 34 eyes of 32 patients who developed a hypotonous maculopathy after a trabeculectomy with mitomycin C with various treatment strategies. Placement of a Megasoft Bandage Contact Lens in 24 eyes did not result in a notable increase in intraocular pressure or visual acuity. Intrableb injection of autologous blood in 22 eyes resulted in a mean +/- standard deviation (S.D.) increase in intraocular pressure from 4.3 +/- 1.8 mm Hg before injection to 8.6 +/- 4.6 mm Hg after injection. Mean logMAR visual acuity improved from 0.71 +/- 0.40 to 0.32 +/- 0.25. After a surgical revision of 16 eyes, intraocular pressure increased from 4.1 +/- 1.9 mm Hg to 11.3 +/- 4.0 mm Hg, and logMAR visual acuity improved from 0.61 +/- 0.30 to 0.22 +/- 0.24. At the last follow-up examination (12.2 +/- 5.1 months after the trabeculectomy), 31 eyes (91.2%) had an intraocular pressure greater than 6 mm Hg. Hypotonous maculopathy after trabeculectomy with mitomycin C can be treated successfully by autologous blood injection and surgical revision of the filtration site.
authors.affiliation: Department of Ophthalmology, University of Amsterdam, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Nuyts
authors.forename: E L
authors.initials: EL
authors.lastname: Greve
authors.forename: H C
authors.initials: HC
authors.lastname: Geijssen
authors.forename: C T
authors.initials: CT
authors.lastname: Langerhorst
mesh_terms: D000328:Adult; D000368:Aged; D001804:Blood Transfusion, Autologous; D003261:Contact Lenses; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*; D015814:Ocular Hypotension / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D012086:Reoperation; D012164:Retinal Diseases / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D013524:Surgical Flaps; D014130:Trabeculectomy / Q000009:adverse effects*; D014792:Visual Acuity
chemical_list: D016685:Mitomycin