Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation.
The antioxidant property of dehydrozingerone and its analogs were investigated in the ferric-ascorbate induced lipid peroxidation model in rat brain homogenate. All the non phenolic compounds were either inactive or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Based on their IC50 values several of these compounds are more potent than vitamin E and hence may be of potential use in various diseases caused by oxidant stress.
Rajakumar
D V
DV
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Rao
M N
MN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000737:chemistry / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005290:Ferric Compounds; D013343:Styrenes; D017392:Thiobarbituric Acid Reactive Substances; C052933:methyl-3-methoxy-4-hydroxystyryl ketone; C061126:iron(III)-ascorbic acid complex; D001205:Ascorbic Acid