title: Increased parental ages and uniparental disomy 15: a paternal age effect?
abstract: Parental ages associated with both maternal and paternal uniparental disomy (UPD) of chromosome 15 are highly elevated in comparison to Zurich population-based controls, with mean maternal and paternal ages of 35.6 and 38.1, respectively for UPD patients (diagnosed in Zurich) and 28.0 and 31.0, in controls. The parental ages are also significantly higher than observed for trisomies of other chromosomes diagnosed in Zurich. The higher age of UPD cases may be due to the fact that two errors, both a gain and a loss of a chromosome 15, are necessary. We suggest that gamete complementation, zygote formation from two gametes one of which is nullisomic and the other disomic for the same chromosome, may be a major mechanism of UPD formation, as well as secondary loss of a chromosome in a trisomic conception, and that there is an association between increased paternal age and nondisjunction.
authors.affiliation: Institute for Medical Genetics, University of Zurich, Switzerland.
authors.forename: W P
authors.initials: WP
authors.lastname: Robinson
authors.forename: I
authors.initials: I
authors.lastname: Lorda-Sanchez
authors.forename: S
authors.initials: S
authors.lastname: Malcolm
authors.forename: S
authors.initials: S
authors.lastname: Langlois
authors.forename: S
authors.initials: S
authors.lastname: Schuffenhauer
authors.forename: H
authors.initials: H
authors.lastname: Knoblauch
authors.forename: B
authors.initials: B
authors.lastname: Horsthemke
authors.forename: A A
authors.initials: AA
authors.lastname: Schinzel
mesh_terms: D000328:Adult; D017204:Angelman Syndrome / Q000235:genetics; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D009630:Nondisjunction, Genetic; D010331:Paternal Age; D011218:Prader-Willi Syndrome / Q000235:genetics