beta-Lactamase inhibitors derived from N-tosyloxy-beta-lactams.
Electrophilic N-tosyloxy-beta-lactams, N-tosyloxy-4-phenyl-2-azetidinone (2b) and N-tosyloxy-3-(S)-phthalimido-4-(S)-2-azetidinone (2c), are described. These agents are novel potent beta-lactamase inhibitors.
Teng
M
M
Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556.
Miller
M J
MJ
Nicas
T I
TI
Grissom-Arnold
J
J
Cooper
R D
RD
D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014105:Tosyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
D001384:Azetidines; C089353:N-tosyloxy-3-phthalimido-4-methyl-2-azetidinone; C089352:N-tosyloxy-4-phenyl-2-azetidinone; D010797:Phthalimides; D014105:Tosyl Compounds; D065093:beta-Lactamase Inhibitors