Low tissue gastrin content in the ovine distal duodenum is associated with increased percentage of G34.
1. In adult sheep and in lambs, over 95% of gastrin in the abomasal antrum was G17 with small amounts of G34 and lesser amounts of Component I. 2. Low gastrin concentration in the proximal duodenum was associated with a reduced percentage of G17. 3. The proportion of G34 increased progressively down the duodenum from a mean of 7% proximally to 47% in the most distal segment, and correlated negatively in any segment with the gastrin content. 4. In both the antrum and proximal duodenum, 60-70% of the G17 was in the sulphated form. 5. The gastroepiploic venous serum contained less G17 and more G34 than the tissues and up to 19% G14.
Simpson
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HV
Department of Physiology and Anatomy, Massey University, Palmerston North, New Zealand.
Reynolds
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GW
Carr
D H
DH
D000375:Aging / Q000378:metabolism; D000818:Animals; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D011498:Protein Precursors / Q000097:blood / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism; D011863:Radioimmunoassay; D012756:Sheep; D013431:Sulfates / Q000378:metabolism
D005755:Gastrins; D011498:Protein Precursors; D013431:Sulfates; C013706:big gastrin; C013550:gastrin 17