title: Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene maps on chromosome 1.
abstract: Thioredoxins are involved in various biochemical systems and mediate both redox and nonredox functions. In mammalian cells, thioredoxin functions as an endogenous glucocorticoid receptor activating factor and as an adult T-cell leukemia-derived factor (ADF) that stimulates expression of interleukin-2 receptor in human T-cell leukemia virus (HTLV)-I transformed T cells. We have mapped the thioredoxin gene (Txn) and its processed pseudogene (Txn-ps1) in the mouse using a panel of interspecific backcross mice. Txn maps to Chr 4, whereas Txn-ps1 maps to the proximal region of Chr 1.
authors.affiliation: Banyu Tsukuba Research Institute (Merck), Japan.
authors.forename: M
authors.initials: M
authors.lastname: Taketo
authors.forename: M
authors.initials: M
authors.lastname: Matsui
authors.forename: J M
authors.initials: JM
authors.lastname: Rochelle
authors.forename: J
authors.initials: J
authors.lastname: Yodoi
authors.forename: M F
authors.initials: MF
authors.lastname: Seldin
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D006801:Humans; D008540:Meiosis; D051379:Mice / Q000235:genetics*; D008809:Mice, Inbred C3H; D009115:Muridae / Q000235:genetics; D011544:Pseudogenes; D013045:Species Specificity; D013879:Thioredoxins / Q000235:genetics*
chemical_list: D013879:Thioredoxins