Acute and chronic effect of ethanol on the occurrence of alloxan diabetes in rats.
We investigated the chronic and acute effect of ethanol on alloxan-induced diabetes in rats. When 1 ml/100 g b.w. of 35% ethanol solution was intraperitoneally injected into rats 10 min before intramuscular injection of alloxan, the alloxan-induced diabetes was completely prevented at the alloxan dosis (150, 200 mg/kg b.w.) at which the disease is unfailingly induced in control rats. This finding confirmed the results of Heikkila, Barden and Cohen. On the other hand, when rats were given 10% ethanol solution instead of water for 40 straight days, alloxan at a dose of 130 or 140 mg/kg caused diabetes in all cases, whereas no controls developed diabetes. This demonstrable effect of the promotion of alloxan-induced diabetes by chronic alcohol administration was the exact opposite of the acute effect of alcohol. We discussed the contradictory action of ethanol in relation to the occurrence of alloxan diabetes in rats.
Katsumata
K
K
Katsumata Hospital, Nagoya, Japan.
Katsumata
K
K
Katsumata
Y
Y
Ozawa
T
T
D000496:Alloxan / Q000008:administration & dosage; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D000431:Ethanol / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000431:Ethanol; D000496:Alloxan