title: Congenital anorchism: diagnostic and therapeutic aspects.
abstract: Eight patients with congenital anorchism were examined and treated. Plasma LH, FSH, and testosterone concentrations and the saliva testosterone level were measured by RIA in 3 patients. The results showed a 2.75 times increase in LH level, a 1.66 times increase in FSH level, and hardly measurable serum and saliva testosterone amounts. A dynamic provocating test was applied in 4 patients by Pregnyl (2000 and 4000 IU) and the results showed absence of the gonads. The semen quality control manifested a low volume of ejaculate and aspermia. Scyntiscanning of 6 patients demonstrated no functional testicular parenchyma. Substitute androgen therapy in patients with diagnosed anorchism gave good results, which suggests that this treatment is appropriate and promising. Implantation of testiculo-prostheses by using silicon alloplastic material corrects the cosmetic defect and overcomes the physiological barrier caused by the biological inferiority complex.
authors.affiliation: Clinical Centre of Urology, Medical Faculty, Sofia, Bulgaria.
authors.forename: D
authors.initials: D
authors.lastname: Tzvetkov
authors.forename: P
authors.initials: P
authors.lastname: Tzvetkova
authors.forename: L
authors.initials: L
authors.lastname: Kanchev
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D000013:Congenital Abnormalities / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013737:Testis / Q000002:abnormalities*; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone