title: Effects of sterigmatocystin and T-2 toxin on the induction of unscheduled DNA synthesis in primary cultures of human gastric epithelial cells.
abstract: Primary cultures of human gastric epithelial cells were tested for induction of unscheduled DNA synthesis (UDS) by sterigmatocystin (ST) and T-2 toxin. Autoradiographic results indicated that ST (10(-6)-10(-4)M) induced UDS in the presence of S9 activation system. The repair rates were 24-91% (net grains > or = 3) and 2-71% (net grains > or = 5). T-2 toxin did not induce UDS in this study.
authors.affiliation: Laboratory of Mycotoxicology, Beijing Institute for Cancer Research, China.
authors.forename: X
authors.initials: X
authors.lastname: Ji
authors.forename: Y
authors.initials: Y
authors.lastname: Ke
authors.forename: T
authors.initials: T
authors.lastname: Ning
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Shi
mesh_terms: D000818:Animals; D001345:Autoradiography; D001711:Biotransformation; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013241:Sterigmatocystin / Q000493:pharmacokinetics / Q000633:toxicity*; D013605:T-2 Toxin / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D013241:Sterigmatocystin; D004247:DNA; D013605:T-2 Toxin