title: Effect of diclofenac on fixation of hydroxyapatite-coated implants. An experimental study.
abstract: We studied the effect of non-steroidal anti-inflammatory drugs on the fixation of hydroxyapatite-coated implants. Cylindrical plugs of pure titanium, coated with hydroxyapatite (HA), were inserted into both femora of 10 adult rabbits, 5 of which received 7 daily doses of 30 mg diclofenac. Three weeks after implantation the interface strengths were measured by the pull-out test. The mean peak force for the diclofenac-treated group was 290 +/- 57 N compared with 369 +/- 37 N for the control group (p < 0.025). We conclude that the inhibitory effect of diclofenac on bone repair is not neutralised by HA-coating of an implant.
authors.affiliation: University Hospital, Linköping, Sweden.
authors.forename: S A
authors.initials: SA
authors.lastname: Jacobsson
authors.forename: K
authors.initials: K
authors.lastname: Djerf
authors.forename: I
authors.initials: I
authors.lastname: Ivarsson
authors.forename: O
authors.initials: O
authors.lastname: Wahlström
mesh_terms: D000818:Animals; D004008:Diclofenac / Q000494:pharmacology*; D004347:Drug Interactions; D017886:Durapatite; D005260:Female; D006622:Hip Prosthesis / Q000295:instrumentation / Q000379:methods*; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D009999:Ossification, Heterotopic / Q000503:physiopathology / Q000517:prevention & control*; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium; D016474:Weight-Bearing
chemical_list: D004008:Diclofenac; D017886:Durapatite; D014025:Titanium