[CNS-active pyrans: amine- and aryl- substituted dioxabicyclooctanes].
The amin- and phenyl substituted 6,8-dioxabicyclooctanes 10 and 11 show distinct CNS-activities. Intensity and profile depend on the type of amine and the stereochemistry of the products. Therefore, we have synthesized 6,8-dioxabicyclooctanes with different amine-phenyl distances and examined their CNS-activities on mice as well as by receptor binding studies with the PCP-binding site which is part of the NMDA-receptor-complex.
Eiden
F
F
Institut für Pharmazie und Lebensmittelchemie, Ludwig-Maximilians-Universität, München.
Denk
F
F
Höfner
G
G
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011869:Radioligand Assay; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D017478:Receptors, Phencyclidine / Q000187:drug effects
D001643:Bridged Bicyclo Compounds; D002491:Central Nervous System Agents; D016194:Receptors, N-Methyl-D-Aspartate; D017478:Receptors, Phencyclidine
ZNS-wirksame Pyrane: Amin- und arylsubstituierte Dioxabicyclooctane.