Reconstruction of the anterior laryngeal wall with a composite graft of demineralized bovine bone matrix and autogenous perichondrium. An experimental study in adult rabbits.
In this study the feasibility to reconstruct the anterior laryngeal wall in adult rabbits with a composite graft of demineralized bovine bone matrix and autogenous perichondrium was investigated. It is demonstrated that demineralized bovine bone, which is a porous biomaterial, is completely transformed into autologous cartilage, once it is implanted in a vascularized perichondrial pocket. It appeared to be possible to reconstruct the anterior laryngeal wall in adult rabbits with this newly formed cartilage. As the biomaterial has been transformed into autologous tissue it is entirely incorporated at the recipient site giving rise to solid connections (cartilaginous and/or fibrous) with the surrounding tissues.
Bean
J K
JK
Department of Otorhinolaryngology, Dykzigt Hospital/Erasmus University, Rotterdam, The Netherlands.
Verwoerd-Verhoef
H L
HL
Verwoerd
C D
CD
D000818:Animals; D001705:Bioprosthesis; D001857:Bone Matrix / Q000637:transplantation; D002356:Cartilage / Q000637:transplantation; D002417:Cattle; D003413:Cricoid Cartilage / Q000601:surgery; D005260:Female; D007829:Laryngostenosis / Q000601:surgery; D007830:Larynx / Q000601:surgery*; D011817:Rabbits