Effects of stress and ebiratide (Hoe-427) on free-choice ethanol consumption: comparison of Lewis and Sprague-Dawley rats.
The effects of immobilization stress, isolation stress and administration of Hoe-427 on free-choice consumption of ethanol by Lewis and Sprague-Dawley rats were studied. The animals were offered two-bottle choice consumption of 0.2% saccharin and 10% ethanol/0.2% saccharin, then exposed to 4 days of immobilization stress or isolation stress on an irregular, unpredictable schedule or 4 days of i.p. doses of Hoe-427 at 1800 hours. Both stresses resulted in significant decreases in ethanol consumption during the stress period. Hoe-427 produced a significant decrease in ethanol consumption, in a dose-dependent manner. Saccharin consumption was not significantly affected by any of the treatments. The ability to correlate the Lewis and Sprague-Dawley rat response further aids in supporting the role of the adrenocorticotropic peptide in the development of ethanol consumption.
Sprague
J E
JE
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907-1334.
Maickel
R P
RP
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000428:Alcohol Drinking; D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D012439:Saccharin; D012934:Social Isolation; D013045:Species Specificity; D013315:Stress, Psychological
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C057139:ebiratide; D012439:Saccharin