[Retinal S-antigen and retinoblastoma--an immunohistochemical study].
A strain of monoclonal antibody, MabAgC6, which defines an epitope in S-antigen, was used to study S-antigen expression in 10 cases of retinoblastoma, where S-antigen immunoactivity was observed in different patterns: the "normal" photoreceptor elements incorporated in 3 cases of growing tumors, 3 of 4 fleurettes and E-W rosettes, and scattered tumor cells in 50% of the cases were stained positive. The results suggest that the expression of S-antigen in retinoblastoma may be used to assess the degree of tumor differentiation, as another of the tumor markers.
Song
Y
Y
Department of Ophthalmology, Second Clinical College, Norman Bethune University of Medical Sciences, Changchun.
Yao
G D
GD
Fu
C C
CC
D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D019393:Arrestin; D014408:Biomarkers, Tumor / Q000032:analysis*; D005134:Eye Neoplasms / Q000276:immunology*; D005136:Eye Proteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D012175:Retinoblastoma / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens; D019393:Arrestin; D014408:Biomarkers, Tumor; D005136:Eye Proteins