title: Fluoxetine abuse.
abstract: OBJECTIVE
  In this report, we describe the abuse of fluoxetine (an antidepressant) in two patients who had histories of substance abuse.
  
  
  METHODS
  Specific details of the stimulant effects of fluoxetine, used in excessive dosages and in conjunction with other drugs, are discussed.
  
  
  RESULTS
  After hospitalization, our two patients were able to discontinue use of fluoxetine and had improved mentation.
  
  
  CONCLUSIONS
  Although the mechanism for this phenomenon is unknown, we postulate that drug craving and behavioral factors are involved.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic Rochester, MN 55905.
authors.forename: J A
authors.initials: JA
authors.lastname: Tinsley
authors.forename: M W
authors.initials: MW
authors.lastname: Olsen
authors.forename: R R
authors.initials: RR
authors.lastname: Laroche
authors.forename: M A
authors.initials: MA
authors.lastname: Palmen
mesh_terms: D000328:Adult; D005260:Female; D005473:Fluoxetine; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000523:psychology
chemical_list: D005473:Fluoxetine