Antimicrobial activity of 5,6-dihydrobenzo-[a]-carbazoles.
A new series of 5,6-dihydrobenzo[a]carbazoles was synthesized, some showing good antibacterial activity. The presence of a dialkylamino ethyl chain on the 2-, 3- or 4-O-substituent seems to be critical for such activity.
Pappa
H
H
Departmento de Tecnologia Farmacéutica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina.
Segall
A
A
Pizzorno
M T
MT
Radice
M
M
Amoroso
A
A
Gutkind
G O
GO
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
D000890:Anti-Infective Agents; D002227:Carbazoles