Serotonin modulation of pain responsiveness in the aged rat.
This study was designed to examine differences in basal nociceptive responsiveness between young (3 months) and old (25 months) male Fischer-344 rats and also to evaluate the effects of methysergide and fluoxetine on this behavioral paradigm. The results indicate that the aged animals were less sensitive than young animals to pain responsiveness in simple nociceptive tests such as the tail-flick, hot plate (55 degrees C), and hind-paw pressure tests. In both groups of animals, this behavioral response followed a circadian rhythm, with peak of pain latency during the dark phase and trough occurring in the light phase. In all three analgesic tests, treatment with methysergide, which is a serotonin antagonist, resulted in hyperalgesia in both groups of animals within the first hour, followed by a return to basal response level after 2 h. Fluoxetine treatment resulted in a nonsignificant increase in nociceptive response at 30 min posttreatment which returned to the baseline by 1 h. Moreover, in both young and old animals morphine produced moderate analgesia in the hot plate and hind-paw tests, which was potentiated by simultaneous treatment with fluoxetine. This study shows that noxious response was reduced in the aged male Fischer-344 rats, and the data obtained provide evidence that the serotonergic system modulates pain sensitivity similarly in young and old animals.
Akunne
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HC
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105.
Soliman
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KF
D000375:Aging / Q000523:psychology*; D000818:Animals; D004357:Drug Synergism; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000523:psychology*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*
D005473:Fluoxetine; D012701:Serotonin; D009020:Morphine; D008784:Methysergide