[The effect of intravenous cimetidine and histamine on splanchnic circulation in the dogs].
We investigated the effect of cimetidine and histamine on splanchnic circulation in the dogs. Hepatic artery, superior mesenteric artery and portal vein were cannulated to measure each blood pressure. Each blood flow was evaluated utilizing electromagnetic blood flowmetry. And vascular resistances were calculated by measured blood pressure and blood flow. Cimetidine, histamine, 2-PEA (H1-agonist), dimaprit (H2-agonist) and mepyramine maleate (H1-antagonist) were given by intravenous bolus to the dogs. Histamine caused vasodilation of hepatic artery but vasoconstriction of superior mesenteric artery and these effects were similar to the effect of 2-PEA. These hemodynamic responses to histamine were inhibited by H1-antagonist but not inhibited by H2-antagonist. Cimetidine produced dilatation of hepatic artery but constriction of portal vein, superior mesenteric artery and reduced total hepatic blood flow. These effects were not inhibited by H1-antagonist. We concluded that cimetidine did not stimulated H1, H2-receptors rather than had the own effects and that H1-receptor was superior to H2-receptor on splanchnic circulation in the dogs.
Sako
J
J
Department of Surgery, Ohmiya Medical Center, Jichi Medical School.
Yasuda
Y
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D017259:Dimaprit / Q000494:pharmacology; D004285:Dogs; D006499:Hepatic Artery / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008298:Maleates / Q000494:pharmacology; D008638:Mesenteric Arteries / Q000187:drug effects; D011969:Receptors, Histamine H1 / Q000502:physiology; D013152:Splanchnic Circulation / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D006635:Histamine H2 Antagonists; D008298:Maleates; D011969:Receptors, Histamine H1; D002927:Cimetidine; D006632:Histamine; C030272:maleic acid; D017259:Dimaprit