Cognitive impairments induced by triazolam in healthy volunteers: antagonism by a partial inverse agonist of benzodiazepine receptor.
Pharmacological studies revealed that SR 25776 possesses marked stimulant activity characteristic of a partial inverse agonist of benzodiazepine receptor. The effects of SR 25776 500 mg alone and in combination with triazolam 0.25 mg on psychomotor performance and memory were assessed in 8 healthy consenting male volunteers in a double-blind placebo controlled trial. Treatment effects were monitored before and two and half hours following oral medication. The present study suggest that at the studied dose SR 25776 may incompletely antagonize the sedative and amnesic effects of a benzodiazepine agonist without producing marked effects of its own.
Warot
D
D
Département de Pharmacologie, Hôpital Pitié-Salpêtrière, Paris.
Danjou
P
P
Douillet
P
P
Keane
P
P
Puech
A J
AJ
D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced* / Q000453:epidemiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015989:Healthy Worker Effect; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D018079:Receptors, GABA / Q000187:drug effects*; D014229:Triazolam / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014838:Volunteers
D018079:Receptors, GABA; D014229:Triazolam