Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.
1. Drugs were administered to a suprachiasmatic nucleus through a chronically implanted cannula at the second day of a torpor bout of hibernating ground squirrels. After naltrexone injection, the body temperature of the hibernating animals increased and they aroused from hibernation within 20 hr after the injection. 2. Further experiments show that intra-suprachiasmatic nucleus perfusion of 1 nmol of ICI 174864 or nor-BNI, not beta-FNA, were able to increase the body temperature of hibernating ground squirrels and aroused them from hibernation within 20 hr after the injection.
Yu
L C
LC
Department of Physiology, Peking University, Beijing, P.R. China.
Cai
Y P
YP
D000818:Animals; D004723:Endorphins / Q000502:physiology*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D006605:Hibernation / Q000187:drug effects / Q000502:physiology*; D007267:Injections; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009292:Narcotic Antagonists; D011957:Receptors, Opioid / Q000502:physiology*; D012589:Sciuridae / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000502:physiology*
D004723:Endorphins; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; C051844:norbinaltorphimine; D004743:Enkephalin, Leucine; D009271:Naltrexone; C024524:beta-funaltrexamine; C040643:N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine