EDU decreases polymorphonuclear leukocyte production of reactive oxygen intermediates.
The ability of the heterocyclic compound EDU (N-[2-(2-oxo-1-imidazolindinyl)-ethyl]-N'-phenylurea) to affect polymorphonuclear leukocyte (PMNL) activation was examined by measuring superoxide anion, hydrogen peroxide and hydroxyl radical release from human PMNLs stimulated by phorbol ester. Results demonstrated that EDU effectively interferes with PMNLs reactive oxygen intermediate production, making it a potentially useful compound to be used to modulate PMNL-associated oxidant damage of inflamed tissues.
Leanderson
P
P
University of Linköping, Sweden.
Zackrisson
A L
AL
Tagesson
C
C
Boswell
G A
GA
Kerr
J S
JS
Bassett
D J
DJ
D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D009504:Neutrophils / Q000378:metabolism*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000975:Antioxidants; D010671:Phenylurea Compounds; D017382:Reactive Oxygen Species; D013481:Superoxides; D017665:Hydroxyl Radical; C032766:ethylene diurea; D006861:Hydrogen Peroxide; D013755:Tetradecanoylphorbol Acetate