title: Investigations on the synthesis and properties of some N-arylpiperazinylalkyl derivatives of imides of 3,4-pyridinedicarboxylic acids.
abstract: The synthesis of N-arylpiperazinylalkyl derivatives of imides of 3,4-pyridinedicarboxylic acid is described. In pharmacological screening some of the obtained compounds displayed biological activity, but they were inactive as anxiolytic agents.
authors.affiliation: Department of Chemistry of Drugs, School of Medicine, Wroclaw, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007094:Imides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D007094:Imides; D011619:Psychotropic Drugs; D011725:Pyridines; D000661:Amphetamine