title: Effect of moderate obesity on glucose transport in human muscle.
abstract: We have shown that maximally stimulated glucose transport is reduced in in vitro incubated muscle of morbidly obese subjects. To investigate the possibility that a "threshold" of obesity exists, above which glucose transport is significantly decreased, hormone (insulin, IGF-I, or IGF-II) stimulation of glucose transport was correlated with body mass index using muscle biopsies from a group of 30 lean to obese females with BMI ranging from 16 to 40. There was a significant negative relationship between stimulation for glucose transport and BMI (R = 0.765). These data suggest there is no obesity threshold for insulin resistance in skeletal muscle but a continuous decline in glucose transport below a BMI of approximately 30 kg/m2, after which insulin and the IGFs no longer stimulate glucose transport.
authors.affiliation: Department of Biochemistry, East Carolina University School of Medicine, Greenville, North Carolina.
authors.forename: C W
authors.initials: CW
authors.lastname: Elton
authors.forename: E B
authors.initials: EB
authors.lastname: Tapscott
authors.forename: W J
authors.initials: WJ
authors.lastname: Pories
authors.forename: G L
authors.initials: GL
authors.lastname: Dohm
mesh_terms: D019325:3-O-Methylglucose; D000293:Adolescent; D000328:Adult; D001835:Body Weight / Q000502:physiology; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology; D008757:Methylglucosides / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D017568:Rectus Abdominis / Q000187:drug effects / Q000378:metabolism
chemical_list: D007328:Insulin; D008757:Methylglucosides; D019325:3-O-Methylglucose; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D003847:Deoxyglucose; D005947:Glucose