title: Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.
abstract: We have determined the chromosomal location of the human genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S alpha 3 and beta 3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3-4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor, Créteil, France.
authors.forename: G
authors.initials: G
authors.lastname: Giuili
authors.forename: N
authors.initials: N
authors.lastname: Roechel
authors.forename: U
authors.initials: U
authors.lastname: Scholl
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: G
authors.initials: G
authors.lastname: Guellaen
mesh_terms: D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006162:Guanylate Cyclase / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D012995:Solubility
chemical_list: D006162:Guanylate Cyclase