title: Idiopathic progressive glomerulopathy with extensive subendothelial and mesangial immune deposit formation.
abstract: A 32-year-old Japanese male presented with abundant proteinuria, and renal biopsy revealed diffuse subendothelial and mesangial deposits in the glomeruli without hypercellularity or mesangial interposition. There was no clinical or laboratory evidence of systemic conditions such as collagen-vascular disease, paraproteinemia, or infection. Treatment with corticosteroid was ineffective and the patient eventually went into end-stage renal failure. To our knowledge, this is the first report of an idiopathic progressive glomerulopathy characterized by diffuse, global subendothelial and mesangial deposits, which suggests to us a novel insight into glomerular subendothelial/mesangial deposition.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Konishi
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Saruta
authors.forename: H
authors.initials: H
authors.lastname: Sakaguchi
mesh_terms: D000328:Adult; D001706:Biopsy; D003165:Complement System Proteins / Q000032:analysis*; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D006435:Renal Dialysis
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins