title: Colorectal cancer in patients with X-linked agammaglobulinaemia.
abstract: Primary immunodeficiency disorders can predispose to certain malignancies but hitherto no such relation has been established for X-linked agammaglobulinaemia (XLA). We have diagnosed rapidly progressive colorectal cancer in 3 unrelated young adults with XLA. We could find no explanation for the tumours. Since the calculated incidence of rectosigmoid cancer is increased 30-fold in patients with XLA, we advise the screening of these individuals, and perhaps people with other agammaglobulinaemias, for colorectal cancer.
authors.affiliation: Department of General Internal Medicine, University Hospital Nijmegen, Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
authors.forename: R S
authors.initials: RS
authors.lastname: Weening
authors.forename: P T
authors.initials: PT
authors.lastname: Schellekens
authors.forename: I P
authors.initials: IP
authors.lastname: van Munster
authors.forename: F M
authors.initials: FM
authors.lastname: Nagengast
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000150:complications*; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D014960:X Chromosome