Enhanced aggressive behavior in mice lacking 5-HT1B receptor.
The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.
Saudou
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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U184 de l'INSERM, Faculté de Médecine, Strasbourg, France.
Amara
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DA
Dierich
A
A
LeMeur
M
M
Ramboz
S
S
Segu
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L
Buhot
M C
MC
Hen
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R
D000374:Aggression / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D002678:Chimera; D005260:Female; D007211:Indoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009154:Mutation; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D011995:Recombination, Genetic; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D007211:Indoles; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; C047975:cyanopindolol; D010869:Pindolol