title: Active suppression induced by anti-CD4.
abstract: Treatment with a non-depleting monoclonal antibody to CD4 in the presence of mouse thyroglobulin (MTg) inhibits the development of murine autoimmune thyroiditis. This unresponsiveness was transferrable since such treatment generated a population of donor cells which could suppress the thyroiditis induced in lightly irradiated recipients by subsequent challenge with specific antigen. The suppression appears to be both antigen specific and antigen dependent and seems to discriminate between TH1 and TH2 helper subsets in that there is no significant effect on anti-MTg autoantibodies after challenge.
authors.affiliation: Immunology Department, University College and Middlesex Medical School, London.
authors.forename: P R
authors.initials: PR
authors.lastname: Hutchings
authors.forename: A
authors.initials: A
authors.lastname: Cooke
authors.forename: K
authors.initials: K
authors.lastname: Dawe
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: I M
authors.initials: IM
authors.lastname: Roitt
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D015704:CD4 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
chemical_list: D015704:CD4 Antigens; D013954:Thyroglobulin