title: The regulation of human globin gene switching.
abstract: This paper describes the mechanism of regulation of the human beta-globin on the basis of a number of natural mutations and experiments in transgenic mice. From these data we conclude that this multigene locus is regulated at a number of different levels involving specific interactions between the Locus Control Region (LCR) and the individual genes. Most important is the action of stage specific transcription factors acting on sequences immediately flanking the genes. In addition, specificity is obtained through specific interaction of the genes with the LCR and through competition of the genes for interaction with the LCR.
authors.affiliation: Laboratory of Gene Structure & Expression, National Institute for Medical Research, Mill Hill, London, U.K.
authors.forename: F
authors.initials: F
authors.lastname: Grosveld
authors.forename: M
authors.initials: M
authors.lastname: Antoniou
authors.forename: M
authors.initials: M
authors.lastname: Berry
authors.forename: E
authors.initials: E
authors.lastname: De Boer
authors.forename: N
authors.initials: N
authors.lastname: Dillon
authors.forename: J
authors.initials: J
authors.lastname: Ellis
authors.forename: P
authors.initials: P
authors.lastname: Fraser
authors.forename: O
authors.initials: O
authors.lastname: Hanscombe
authors.forename: J
authors.initials: J
authors.lastname: Hurst
authors.forename: A
authors.initials: A
authors.lastname: Imam
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005786:Gene Expression Regulation; D005812:Genes, Switch; D005914:Globins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D005810:Multigene Family
chemical_list: D005914:Globins