title: [Defect bridging and augmentation of the mandible by transplantation of locally cultured bone in a porous matrix].
abstract: In the present study, 9 Göttingen Minipigs received one porous hydroxylapatite block each on the buccal cortex of their mandibles. Autogenous bone was gained inside these blocks by using a polylactic membrane covering for guided tissue regeneration. The blocks showed thorough penetration by bone tissue after 5 months and were transplanted as onlay grafts and for restoration of mandibular defects. The onlay grafts were fixed by titanium fixtures and miniplates respectively. Histologic examination 3 months after transplantation showed maintenance and remodelling of the transplanted bone inside the pores of the blocks in most specimens. There war a soft tissue free contact between the transplanted bone and the inserted fixtures and screws. Results indicate that autogenous bone may be gained inside a porous matrix of calcium phosphate and be transplanted for reconstruction of contour and discontinuity defects.
authors.affiliation: Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie Medizinische Hochschule Hannover.
authors.forename: H
authors.initials: H
authors.lastname: Schliephake
authors.forename: F W
authors.initials: FW
authors.lastname: Neukam
authors.forename: D
authors.initials: D
authors.lastname: Hutmacher
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation / Q000473:pathology / Q000502:physiology*; D017886:Durapatite; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D016348:Osseointegration / Q000502:physiology*; D019736:Prostheses and Implants; D013552:Swine; D013556:Swine, Miniature
chemical_list: D017886:Durapatite
vernacular_title: Defektüberbrückung und Augmentation des Unterkiefers durch Transplantation von ortsständig angezüchtetem Knochen in einer porösen Matrix.