[The role of monoamin- and acidergic mechanisms of the hippocampus in anxiety states of different origins and their participation in the antiaversive effects of anxiolytics].
The experiments on rats with tests of avoiding "lighting square" and "threatening situation" and with the chemical stimulation of dorsal and ventral hippocampus with dopamine, 5-HT, GABA and glutamine acid, showed different functional significance of these monoamines and acidergic transmitters agents in the states of anxiety of heteromodal aversive genesis. It seems that the variations in the action spectrum of anxiolytics under study are due to unequal degree of 5-HT and GABA-ergic transmitter mechanisms of dorsal and ventral hippocampus.
Talalaenko
A N
AN
Krivobok
G K
GK
Stakhovskiĭ
Iu V
IuV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D002707:Chlordiazepoxide / Q000627:therapeutic use; D004195:Disease Models, Animal; D004298:Dopamine; D004353:Drug Evaluation, Preclinical; D005971:Glutamates; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin; D005680:gamma-Aminobutyric Acid
D014151:Anti-Anxiety Agents; D005971:Glutamates; D011956:Receptors, Cell Surface; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D002707:Chlordiazepoxide; D004298:Dopamine
O roli monoamin- i atsidergicheskikh mekhanizmov gippokampa v sostoianii trevogi razlichnogo geneza i ob ikh uchastii v antiaversivnykh éffektakh anksiolitikov.