Sulfamethizole capsule method. A new method for assessing gastric emptying of solids.
We have developed a new method that is capable of assessing gastric emptying in humans. This method is based on the rapid absorption of sulfamethizole in the upper small intestine. Sulfamethizole capsules are gelatin capsules that are filled with a solid composed of egg albumin and sulfamethizole. After subjects ingested of 15 capsules with ham and bread, blood concentrations of sulfamethizole were measured and the areas under the sulfamethizole concentration-time curve (AUC) were calculated as an index of gastric emptying. After ingestion of 99mTc-labeled sulfamethizole capsules, there was a statistically significant correlation between the percentage of radioactivity remaining in the stomach at 120 min and AUC for 120 min (r = -0.82, P < 0.01). This method yielded a reliable value for gastric emptying of a solid meal as estimated by AUC. This method can be considered safe and is easily applicable to human subjects for assessment of gastric emptying.
Asada
T
T
Department of Geriatric Medicine and Nuclear Medicine, Kyoto University Hospital, Japan.
Murakami
M
M
Sako
Y
Y
Fukushima
Y
Y
Yonekura
Y
Y
Konishi
J
J
Kita
T
T
Miyake
T
T
Asada
T
T
D000328:Adult; D000368:Aged; D002214:Capsules; D003920:Diabetes Mellitus / Q000503:physiopathology; D004063:Digestion / Q000502:physiology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012016:Reference Values; D015203:Reproducibility of Results; D013419:Sulfamethizole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D002214:Capsules; D013419:Sulfamethizole