[The nephrotoxic action of heavy crude with a high vanadium content and of its refinery products].
The samples of vanadium-rich oil obtained from the field in Buzachi peninsula and of this oil products were applied subcutaneously to hybrid mice. In response to the application 27.5-56.6% of the animals developed renal impairment manifest morphologically in the range from acute proliferative glomerulonephritis to nephrosclerosis. Nephrotoxicity of the products increased with elevation of their sublimation temperature. Vanadium concentrations grew respectively. Intraperitoneal introduction of the products to rats provoked acute intracapillary glomerulonephritis with partial tubular and glomerular necrosis associated with acute renal failure.
Sarsebekov
E K
EK
Dzharbusynov
B U
BU
Doskeeva
R A
RA
D000818:Animals; D007623:Kazakhstan; D007668:Kidney / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010578:Petroleum / Q000633:toxicity*; D051381:Rats; D013696:Temperature; D014639:Vanadium / Q000633:toxicity*
D010578:Petroleum; D014639:Vanadium
Nefrotoksicheskoe deĭstvie tiazheloĭ, s vysokim soderzhaniem vanadiia nefti i produktov ee pererabotki.