title: Clinical benefits of high and variable sodium concentration dialysate in hemodialysis patients.
abstract: Twenty-one hemodialysis patients were studied during 25 dialysis sessions with a dialysate sodium of 140 mEq/L and during 25 sessions with a high and variable sodium dialysate (145 mEq/L decreased to 140 mEq/L). Bicarbonate dialysate and ultrafiltration-controlled dialysis equipment were used. Neither the average interdialytic weight gain nor the predialysis and postdialysis blood pressures changed. The need for 5% saline infusions decreased from 168 + 137 ml/patient to 2 + 6 ml/patient for 25 dialyses. Use of 0.9% saline boluses remain unchanged. Fewer dialysis sessions required the use of the Trendelenburg position (p < .02) or a decrease in the transmembrane pressure (p < .05). With the use of high and variable sodium dialysate concentration, patients had less symptomatic hypotension (p < .05) and fewer symptoms of dialysis dysequilibrium, such as cramps or nausea.
authors.forename: B M
authors.initials: BM
authors.lastname: Jenson
authors.forename: S A
authors.initials: SA
authors.lastname: Dobbe
authors.forename: D P
authors.initials: DP
authors.lastname: Squillace
authors.forename: J T
authors.initials: JT
authors.lastname: McCarthy
mesh_terms: D000368:Aged; D001794:Blood Pressure; D015314:Dialysis Solutions; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology; D008297:Male; D011187:Posture; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods* / Q000451:nursing; D012964:Sodium; D015430:Weight Gain
chemical_list: D015314:Dialysis Solutions; D012964:Sodium