title: In-vitro permeation of some beta-blockers across the hairless mouse skin.
abstract: To support the development of a suitable transdermal dosage form for beta-blockers, in-vitro, skin permeation studies of nine beta-blockers were conducted at 37 degrees C across the excised abdominal skin of hairless mouse mounted on the receptor compartment of a two-chambered Valia-Chien glass diffusion cell. The drugs varied in lipophilicity, whereas pKa values were comparable. Permeability coefficients were calculated from the steady-state flux values. Agreement was found between the permeability coefficient and the drug lipophilicity, expressed as the octanol-buffer distribution coefficient.
authors.affiliation: Division of Medicinal Chemistry and Pharmaceutics, School of Pharmacy, Northeast Louisiana University, Monroe 71209.
authors.forename: T K
authors.initials: TK
authors.lastname: Ghosh
authors.forename: C S
authors.initials: CS
authors.lastname: Chiao
authors.forename: R D
authors.initials: RD
authors.lastname: Gokhale
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012869:Skin Absorption
chemical_list: D000319:Adrenergic beta-Antagonists