title: Reduction of free radical generation minimises lower limb swelling following femoropopliteal bypass surgery.
abstract: Oxygen-derived free radicals have been implicated as contributors to the development of lower limb oedema observed after femoropopliteal bypass grafting. This study investigates the occurrence of free radical-induced lipid peroxidation after this operation and the possible effects of allopurinol (xanthine oxidase inhibitor) in reducing free radical injury in order to minimise lower leg oedema. Twenty-nine patients undergoing femoropopliteal bypass surgery were randomised in a double blind fashion into two groups; those in one were given allopurinol 200 mg orally (n = 15) at 24 h and 2 h preoperatively and again at 24 h postoperatively, while those in the second group received a placebo (n = 14). Daily lower limb volume was calculated to assess swelling. Blood samples were taken from the femoral vein for measurements of malondialdehyde (MDA), an end product of lipid peroxidation, before the application of the femoral artery clamp, just prior to and immediately after clamp release, and at 20 minute intervals thereafter for 1 hour. The increase in lower limb volume in the placebo group was almost twice (8.9 +/- 1.6%) that of the allopurinol group (4.6 +/- 1%; p = 0.02). Six out of the 14 patients receiving placebo suffered swelling of 10% or more of original lower limb volume in comparison to only one out of 15 in those given allopurinol (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Vascular Surgery Unit, Royal Victoria Hospital Belfast, U.K.
authors.forename: C V
authors.initials: CV
authors.lastname: Soong
authors.forename: I S
authors.initials: IS
authors.lastname: Young
authors.forename: J H
authors.initials: JH
authors.lastname: Lightbody
authors.forename: J M
authors.initials: JM
authors.lastname: Hood
authors.forename: B J
authors.initials: BJ
authors.lastname: Rowlands
authors.forename: E R
authors.initials: ER
authors.lastname: Trimble
authors.forename: A A
authors.initials: AA
authors.lastname: Barros D'Sa
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use*; D001807:Blood Vessel Prosthesis; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control*; D005263:Femoral Artery / Q000601:surgery*; D016166:Free Radical Scavengers; D006801:Humans; D007383:Intermittent Claudication / Q000601:surgery*; D007866:Leg; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D011150:Popliteal Artery / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D016166:Free Radical Scavengers; D008315:Malondialdehyde; D000493:Allopurinol