Toxicity associated with severe inhalational and dermal exposure to dimethylacetamide and 1,2-ethanediamine.
We present the case of a worker who was accidentally exposed (inhalational and dermal routes) to the chemicals dimethylacetamide and ethylenediamine for 90 minutes in a confined space. Clinical effects included delirium, hallucinations, skin burns, cellulitis, bilateral conjunctivitis, hepatitis, secondary coagulopathy, rhabdomyolysis, and a grade 2 esophagitis. Urinary monomethylacetamide levels 6 days after the exposure were 61 ppm.
Marino
G
G
Department of Medicine, New England Deaconness Hospital, Boston, Massachusetts.
Anastopoulos
H
H
Woolf
A D
AD
D000062:Accidents, Occupational; D000081:Acetamides / Q000378:metabolism / Q000506:poisoning*; D000328:Adult; D002057:Burns, Chemical / Q000209:etiology* / Q000503:physiopathology; D002059:Burns, Inhalation / Q000209:etiology* / Q000503:physiopathology; D002617:Chemical Industry; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004941:Esophagitis / Q000139:chemically induced; D004945:Esophagoscopy; D005029:Ethylenediamines / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects; D012871:Skin Diseases / Q000139:chemically induced
D000081:Acetamides; D005029:Ethylenediamines; C031234:ethylenediamine; C013959:dimethylacetamide