Evidence from desensitization studies for distinct receptors for ATP and UTP on the rat superior cervical ganglion.
Prolonged contact of the rat superior cervical ganglia (SCG) with the purine alpha,beta-methylene-ATP (alpha,beta-Me-ATP) selectively depressed responses to ATP and alpha,beta-Me-ATP but not responses to uridine 5'-triphosphate (UTP), potassium or adenosine. Prolonged contact with the pyrimidine UTP selectively depressed responses to UTP but not responses evoked by alpha,beta-Me-ATP, potassium or adenosine. These results are consistent with the presence of P2-purinoceptors and pyrimidinoceptors on the rat SCG and the hypothesis that pyrimidinoceptors exist within the nervous system.
Connolly
G P
GP
Department of Physiology, University College London.
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000378:metabolism*; D017783:Superior Cervical Ganglion / Q000187:drug effects / Q000378:metabolism*; D014544:Uridine Triphosphate / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D011956:Receptors, Cell Surface; D018048:Receptors, Purinergic P2; D014970:Xanthines; C074644:uridine triphosphate receptors; D000255:Adenosine Triphosphate; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D014544:Uridine Triphosphate