[Growth type of colorectal cancer invasion of the proper muscle in relation to DNA ploidy and distribution of PCNA].
In order to elucidate the biological characteristics of colorectal cancer invading the proper muscle, we analyzed DNA ploidy and PCNA labeling index. The growth patterns were divided into three types; those accompanied by intramucosal polypoid growth (PG+), those with non-polypoid growth (PG-), and those ranging between PG+ and PG- (PG+/-). The relationship of DNA ploidy to lymphatic vessel permeation and recurrence was also discussed. The results were as follows: 1) Growth types bore no relation to DNA ploidy and distribution of PCNA. 2) In aneuploidy cancer, it showed a high incidence of lymphatic vessel permeation. A trend of lymphatic metastasis was also observed. Aneuploidy cancer showed a poor prognosis compared with diploidy cancer.
Jin
Y
Y
First Dept. of Surgery, University of Tokyo.
Jin
Z
Z
Sawada
T
T
Kubota
Y
Y
Suzuki
K
K
Watanabe
T
T
Sameshima
S
S
Shinozaki
M
M
Tsuno
N
N
Muto
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002455:Cell Division; D003110:Colonic Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000032:analysis*; D011003:Ploidies; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen
D004273:DNA, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen