title: Predicting pure tone thresholds in normal and hearing-impaired ears with distortion product emission and age.
abstract: Distortion product emission (DPE) growth functions, demographic data, and pure tone thresholds were recorded in 229 normal-hearing and hearing-impaired ears. Half of the data set (115 ears) was used by a discriminant analysis routine to classify DPE and demographic features into either a normal pure tone threshold (PTT) group or an impaired PTT group (PTT greater than 30 dB SPL) at six frequencies in the audiometric range. The six discriminant functions developed from this classification process were then used to predict pure tone threshold group membership in the remaining 114-ear data set. Frequency-specific prediction accuracy varied from 71% (correct classification of hearing impairment at 1025 Hz) to 92% (correct classification of normal hearing at 2050 Hz). Of the 45 DPE and demographic variables evaluated, the DPE amplitude associated with an f2 of moderate level (50 dB SPL) and a frequency corresponding to pure tone threshold was generally most predictive. DPE level was found to be weakly correlated with subject age and perhaps for this reason age was frequently included in discriminant functions. For our data, discriminant functions with one variable, two variables, or 5-10 variables showed no differences in predictive performance. This research suggests that DPE measures can reliably categorize pure tone thresholds as normal or impaired in large populations with varied cochlear hearing status.
authors.affiliation: University of Calgary, Department of Surgery, Faculty of Medicine, Alberta, Canada.
authors.forename: B P
authors.initials: BP
authors.lastname: Kimberley
authors.forename: I
authors.initials: I
authors.lastname: Hernadi
authors.forename: A M
authors.initials: AM
authors.lastname: Lee
authors.forename: D K
authors.initials: DK
authors.lastname: Brown
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology; D005072:Evoked Potentials, Auditory; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests