Philadelphia chromosome positive acute lymphoblastic leukemia masquerading as persistent asymptomatic bone marrow necrosis.
Bone marrow necrosis is an uncommon histologic finding of malignant diseases at presentation. Clinically it is characterized by pyrexia and severe bone pain, and heralds a poor prognosis if untreated. We report an unusual patient with asymptomatic bone marrow necrosis persisting for 10 mths, a hitherto undescribed length of time for this condition. The diagnosis of Philadelphia chromosome positive acute lymphoblastic leukemia was finally made after multiple bone marrow biopsies.
Kwong
Y L
YL
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Pollock
A
A
Wei
D
D
Lie
A K
AK
D000368:Aged; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D003582:Cytogenetics; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008297:Male; D009336:Necrosis; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*