Human prostate cancer cells: inhibition of proliferation by vitamin D analogs.
1,25-Dihydroxyvitamin D [1,25(OH)2D3, calcitriol] can inhibit the proliferation of some human prostate cancer cells but its clinical use is limited by hypercalcemia. We therefore explored the bioactivity of less calcemic vitamin D analogs. We studied the effects of calcitriol and 3 synthetic analogs at concentrations of 10(-6) to 10(-12) M on the in vitro proliferation of 3 human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. Calcitriol and analogs showed significant antiproliferative activity on PC-3 and LNCaP cells. DU 145 cells were inhibited by the analogs only. We conclude that vitamin D analogs warrant further investigation as therapeutic agents in prostate cancer.
Schwartz
G G
GG
Department of Clinical Epidemiology and Family Medicine, University of Pittsburgh Medical Center, PA.
Oeler
T A
TA
Uskoković
M R
MR
Bahnson
R R
RR
D002117:Calcitriol / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured; D014807:Vitamin D / Q000494:pharmacology*; D014809:Vitamin D-Binding Protein / Q000502:physiology
D014809:Vitamin D-Binding Protein; D014807:Vitamin D; D002117:Calcitriol