Early and delayed brain SPECT with technetium-99m-ECD and iodine-123-IMP in subacute strokes.
The brain distribution of 99mTc-ECD versus 123I-IMP was compared in patients with subacute stroke in order to compare diagnostic accuracy.


METHODS
A total of 25 patients with subacute stroke underwent early and delayed SPECT imaging with 99mTc-ECD and 123I-IMP. Washout of 99mTc-ECD was calculated and a differential percentage of activity (DPA) of ischemic versus normal zones was assessed. Images were analyzed twice by five independent observers.


RESULTS
Technetium-99m-ECD clearance was 12.5% from the whole brain during early imaging. Ischemic parietal zones had higher clearance than normal parietal zones. Technetium-99m-ECD images showed larger differences between abnormal and normal brain activity than 123I-IMP images. Detection accuracy was slightly, but not significantly, higher for 99mTc-ECD and 123I-IMP (sensitivity: 73.8% as 66.6%; specificity: 81.7% as 81.6%). Reproducibility among observers was similar for 99mTc-ECD and early 123I-IMP.


CONCLUSIONS
Technetium-99m-ECD demonstrates high diagnostic accuracy during subacute stroke, similar to 123I-IMP, but with more intense, better delineation of the perfusion defects.
Moretti
J L
JL
Service de Médecine Nucléaire, Hôpital Avicenne, Laboratoire de Radiopharmacologie CHU Bobigny, Créteil, France.
Tamgac
F
F
Weinmann
P
P
Caillat-Vigneron
N
N
Belin
C A
CA
Cesaro
P
P
Holman
B L
BL
Defer
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D008961:Models, Structural; D015609:Organotechnetium Compounds; D012680:Sensitivity and Specificity; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
D000662:Amphetamines; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D020367:Iofetamine; C059659:technetium Tc 99m bicisate; D003545:Cysteine