[The dynamics of the metabolic and functional activities of the immunocompetent cells in mice following immunization with different vaccines against Q fever].
It was shown that the immunization of mice by the chemical Q fever vaccine prepared with the use of the strain "Coxiella burnetii, Nine Mile", phase I did not markedly activate the oxidative metabolism of the peritoneal exudate cells and did not induce the non-specific cytotoxicity in them. However, it resulted in a significant suppression of the mitogen-induced proliferation of splenocytes on days 3-5. The immunization of mice by the combined (corpuscular/chemical) vaccine prepared with the use of the strain "Apodemus flavicollis-Luga", phase I induced a significant activation of the oxidative metabolism of the peritoneal exudate cells and the development of the nonspecific cytotoxicity in them, whereas no suppression of the mitogen-induced proliferation of splenocytes was observed. The differences are likely associated with the presence of the corpuscular component in the combined vaccine and the strain antigenic specificity.
Sidorenko
S V
SV
Matsela
A
A
Tokarevich
N K
NK
Daĭter
A B
AB
Tarasevich
I V
IV
Iablonskaia
V A
VA
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D001428:Bacterial Vaccines / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D016997:Coxiella burnetii / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007114:Immunization; D007121:Immunocompetence / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D017778:Vaccines, Combined / Q000276:immunology
D001428:Bacterial Vaccines; D017778:Vaccines, Combined
Dinamika metabolicheskoĭ i funktsional'noĭ aktivnosti immunokompetentnykh kletok mysheĭ posle immunizatsii razlichnymi vaktsinami protiv Ku-likhoradki.