title: Central nervous system lupus: concomitant occurrence of myelopathy and cognitive dysfunction.
abstract: Reported are two cases of patients with central nervous system systemic lupus erythematosus (SLE) with clinical features of a myelopathy confirmed by magnetic resonance imaging (MRI). In one case, further evaluation including Single Photon Emission Computerized Tomography (SPECT) and neuropsychological testing, indicated higher cortical deficits which improved after treatment with monthly pulse intravenous cyclophosphamide. Subsequent cessation of cyclophosphamide was associated with further progression of the neurological disease in this patient.
authors.affiliation: University Department of Rheumatology, Kantonsspital Basel, Switzerland.
authors.forename: H D
authors.initials: HD
authors.lastname: Stahl
authors.forename: T H
authors.initials: TH
authors.lastname: Ettlin
authors.forename: A
authors.initials: A
authors.lastname: Plohmann
authors.forename: E W
authors.initials: EW
authors.lastname: Radü
authors.forename: J
authors.initials: J
authors.lastname: Müller-Brand
authors.forename: U
authors.initials: U
authors.lastname: Steiger
authors.forename: A
authors.initials: A
authors.lastname: Tyndall
mesh_terms: D000328:Adult; D002493:Central Nervous System Diseases / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D009135:Muscular Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D009483:Neuropsychological Tests; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003520:Cyclophosphamide