title: Pregnancy in neuromuscular and skeletal disorders.
abstract: Pregnancy often poses a risk to patients with neuromuscular and skeletal disorders when these affect the respiratory muscles or the rib cage. The outlook is determined both by the severity of the underlying condition and the physiological changes during pregnancy. Patients with a vital capacity of less than 1 to 1.5 litres, hypercapnia, severe scoliosis, diaphragm weakness or pulmonary hypertension before pregnancy are particularly at risk. Pregnancy may adversely affect the conducting airways, respiratory pump and gas exchange in the lungs. Close monitoring of high risk patients during pregnancy is required and either a termination of pregnancy or mechanical respiratory support may be indicated if ventilatory or cardiac failure develops.
authors.affiliation: Papworth Hospital, Cambridgeshire, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Shneerson
mesh_terms: D001847:Bone Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D009468:Neuromuscular Diseases / Q000503:physiopathology*; D007744:Obstetric Labor Complications / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012119:Respiration / Q000502:physiology*; D012120:Respiration Disorders / Q000209:etiology / Q000503:physiopathology