title: Enhanced aggressive behavior in mice lacking 5-HT1B receptor.
abstract: The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.
authors.affiliation: Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U184 de l'INSERM, Faculté de Médecine, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Saudou
authors.forename: D A
authors.initials: DA
authors.lastname: Amara
authors.forename: A
authors.initials: A
authors.lastname: Dierich
authors.forename: M
authors.initials: M
authors.lastname: LeMeur
authors.forename: S
authors.initials: S
authors.lastname: Ramboz
authors.forename: L
authors.initials: L
authors.lastname: Segu
authors.forename: M C
authors.initials: MC
authors.lastname: Buhot
authors.forename: R
authors.initials: R
authors.lastname: Hen
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D002678:Chimera; D005260:Female; D007211:Indoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009154:Mutation; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D011995:Recombination, Genetic; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D007211:Indoles; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; C047975:cyanopindolol; D010869:Pindolol