Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium.
Cardiac hypertrophy in response to systolic pressure loading frequently results in contractile dysfunction of unknown cause. In the present study, pressure loading increased the microtubule component of the cardiac muscle cell cytoskeleton, which was responsible for the cellular contractile dysfunction observed. The linked microtubule and contractile abnormalities were persistent and thus may have significance for the deterioration of initially compensatory cardiac hypertrophy into congestive heart failure.
Tsutsui
H
H
Department of Medicine, Medical University of South Carolina, Charleston.
Ishihara
K
K
Cooper
G
G
D008841:Actin Cytoskeleton / Q000187:drug effects / Q000502:physiology; D000818:Animals; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology*; D002415:Cats; D003078:Colchicine / Q000494:pharmacology; D015638:Cytochalasin D / Q000494:pharmacology; D003893:Desmin / Q000502:physiology; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000503:physiopathology; D007382:Intermediate Filaments / Q000187:drug effects / Q000502:physiology; D008297:Male; D008870:Microtubules / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology*; D017239:Paclitaxel / Q000494:pharmacology; D011312:Pressure; D012518:Sarcomeres / Q000187:drug effects / Q000502:physiology; D016278:Ventricular Function, Right
D003893:Desmin; D015638:Cytochalasin D; D017239:Paclitaxel; D003078:Colchicine