Mapping of a rat multidrug resistance gene by fluorescence in situ hybridization.
A cDNA clone encoding the rat mdr1b (Pgy2) gene was recently isolated and characterized. This gene has a high degree of sequence identity with other Pgy genes, particularly the mouse Pgy2 gene. By means of in situ fluorescence hybridization, the rat Pgy gene was localized on chromosome 4 band q12. This regional mapping will facilitate the identification of synteny groups on rat, mouse, and human genomes and chromosomal rearrangements during mammalian evolution.
Popescu
N C
NC
Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Silverman
J A
JA
Thorgeirsson
S S
SS
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D002874:Chromosome Mapping; D004247:DNA; D015342:DNA Probes; D004351:Drug Resistance / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D051381:Rats
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D015342:DNA Probes; D008562:Membrane Glycoproteins; D004247:DNA