Atrial natriuretic factor: plasma concentration and specific binding to renal glomeruli during the development of genetic hypertension in rats of the Lyon strain.
1. The pathophysiologic role of atrial natriuretic factor (ANF) in genetic hypertension was investigated in 5- and 21-week-old genetically hypertensive (LH), normotensive (LN) and low blood pressure (LL) rats of the Lyon strain. 2. Plasma ANF was significantly higher in 5-week-old LH than in age-matched LN and LL animals. It tended to be lower in 21-week-old LH than in LN rats. 3. Left and right atrial ANF content was also significantly lower at 21 weeks in the LH group. 4. Glomerular ANF receptors showed a significant decrease in LH in comparison to LL and LN animals.
Gauquelin
G
G
Laboratoire de Physiologie de l'Environement, Faculté de Médecine Lyon, Grange-Blanche, France.
Gutkowska
J
J
Vincent
M
M
Sassard
J
J
Gharib
C
C
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D006400:Hematocrit; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D011485:Protein Binding; D051381:Rats
D009320:Atrial Natriuretic Factor