title: Linkage analysis between manic-depressive illness and 35 classical markers.
abstract: The present study used carefully established phenotypes, several methods to reduce misclassification, and conservative genetic parameters. For the 35 markers investigated no evidence of linkage to manic-depressive illness was found, especially not to the markers on chromosomes 4q, 9q, and 19, which earlier has been suggested as possibly being linked to subtypes of manic-depressive illness. Close linkage to FY and SS (GYPB) was excluded for all chosen phenotypic models and to ACP1 and ADA for broader phenotypic models.
authors.affiliation: Department of Psychiatric Demography, University Hospital, Aarhus, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Ewald
authors.forename: O
authors.initials: O
authors.lastname: Mors
authors.forename: H
authors.initials: H
authors.lastname: Eiberg
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype
chemical_list: D005819:Genetic Markers