title: Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism.
abstract: We tested for an association between autism and genes coding for enzymes involved in monoaminergic metabolism and for a linked marker, c-Harvey-Ras-1 (HRAS 1), using restriction fragment length polymorphisms. We did not find evidence of an association between autism and genes coding for tyrosine hydroxylase, dopamine-beta-hydroxylase (DBH), and tryptophan hydroxylase. However, we report a positive association between autism and the locus containing the gene for HRAS-1.
authors.affiliation: National Institute for Health and Medical Research, Tours, France.
authors.forename: J
authors.initials: J
authors.lastname: Hérault
authors.forename: A
authors.initials: A
authors.lastname: Perrot
authors.forename: C
authors.initials: C
authors.lastname: Barthélémy
authors.forename: M
authors.initials: M
authors.lastname: Büchler
authors.forename: C
authors.initials: C
authors.lastname: Cherpi
authors.forename: M
authors.initials: M
authors.lastname: Leboyer
authors.forename: D
authors.initials: D
authors.lastname: Sauvage
authors.forename: G
authors.initials: G
authors.lastname: Lelord
authors.forename: J
authors.initials: J
authors.lastname: Mallet
authors.forename: J P
authors.initials: JP
authors.lastname: Müh
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
chemical_list: D005819:Genetic Markers; D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase; D004299:Dopamine beta-Hydroxylase; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)