[Changes of endogenous opioid peptides content in RPGL during acupuncture analgesia].
By push-pull perfusion technique and RIA of neuro-peptides, it was found that after 20 minutes' electroacupunture (EA), the release of LEK from the RPGL in the EA group was significantly higher than that in the control group (P < 0.05). The release of beta-EP from the RPGL in the EA group with higher efficacy was significantly higher than that in the control group (P < 0.05), but no significant changes were found in the EA group with lower efficacy. There was a positive correlation between the changes of release of LEK or beta-EP and the increase of pain threshold. The release of DynA1-13 tends to show a barely significant extent (P > 0.05). The results indicate that acupuncture analgesia is able to increase the release of LEK and beta-EP in the RPGL.
Zhou
L
L
Department of Neurobiology, Shanghai Medical University.
Jiang
J W
JW
Wu
G C
GC
Cao
X D
XD
D015667:Acupuncture Analgesia; D000818:Animals; D004399:Dynorphins / Q000378:metabolism; D015671:Electroacupuncture; D004743:Enkephalin, Leucine / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D017288:Pain Threshold; D010446:Peptide Fragments / Q000378:metabolism; D051381:Rats; D012154:Reticular Formation / Q000378:metabolism; D001615:beta-Endorphin / Q000378:metabolism*
D010446:Peptide Fragments; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; C026843:dynorphin (1-13); D004399:Dynorphins