Effect of UVB and AS101 on interleukin-2 production and helper activity in psoriatic patients.
Peripheral blood lymphocytes were obtained from eight untreated patients suffering from long-standing plaque-type psoriasis 1 h following UVB treatment and at the end of 15 UVB treatments. Before treatment and following in vivo treatment with 0.01-0.3 J/cm2, the patients' lymphocytes were tested for interleukin-2 (IL-2) production, and helper activity with and without addition of the immunomodulator AS101. AS101 is a synthetic organotellurium compound, ammonium trichloro-(O,O'-dioxyethylene) tellurate. UVB at a flow of 0.01 J/cm2 did not affect any of these functions. However, after 15 UVB treatments, when the dose given had reached 0.3 J/cm2, a complete inhibition of IL-2 production and helper activity was observed. In vitro addition of AS101 at 0.1 micrograms/ml to the in vivo UVB-treated lymphocytes raised IL-2 production to approximately double the initial level, and improved the helper activity of CD4 cells.
Shohat
B
B
Department of Dermatology, Beilinson Medical Center, Petah-Tikva, Israel.
Kozenitzki
L
L
David
M
M
Albeck
M
M
Sredni
B
B
D000276:Adjuvants, Immunologic; D000368:Aged; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D005030:Ethylenes / Q000276:immunology*; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology* / Q000532:radiotherapy*; D051381:Rats; D011917:Rats, Inbred Lew; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000528:radiation effects; D013691:Tellurium; D014467:Ultraviolet Therapy
D000276:Adjuvants, Immunologic; D005030:Ethylenes; D007376:Interleukin-2; C054105:ammonium trichloro(dioxoethylene-O,O'-)tellurate; D013691:Tellurium