title: Doppler spectrum analysis to diagnose rejection during posttransplant acute renal failure.
abstract: During posttransplant acute renal failure (ARF), the diagnosis of allograft rejection constitutes a major problem. We evaluated the value of Doppler ultrasonography in identifying grafts at risk of rejection during ARF. In 184 recipients of a renal allograft, Doppler examinations were performed on the first and fifth postoperative day. Doppler spectra were quantitatively analyzed with a user-written computer program. Doppler findings were not used in clinical decision making. ARF was defined as a diuresis < 400 ml/24 hr and/or the necessity for dialysis. Doppler spectra obtained on the first day after transplantation showed a resistance index (RI) of 0.59 +/- 0.09 in recipients with immediately functioning cadaveric grafts (n = 123), while living related donor grafts (n = 20) showed a lower RI (0.55 +/- 0.07; P < 0.05). Grafts with ARF (n = 41) showed a considerably higher RI (0.67 +/- 0.13; P < 0.05). When grafts with a duration of ARF < or = 4 days (n = 17) were compared with ARF > 4 days (n = 24), RI was not significantly different (0.63 +/- 0.07 vs. 0.68 +/- 0.15; NS). However, the acceleration time of the systolic deflection of the spectrum waveform (Tmax) was shorter in grafts with ARF > 4 days (86 +/- 47 msec vs. 128 +/- 39 msec; P < 0.05). On the fifth day after transplantation, Doppler spectra in grafts with ARF > 4 days (n = 24) showed a Tmax < 90 msec in 9 patients, 8 of whom experienced rejection during ARF (positive predictive value, 8/9 = 89%). In the 15 patients with Tmax > or = 90 msec, only 2 rejections occurred (negative predictive value, 13/15 = 87%). For the RI (> 0.85), positive predictive value was 4/5 = 80% and negative predictive value (RI < or = 0.85) was 13/19 = 68%. In conclusion, a short acceleration time of the Doppler waveform on the first day after transplantation is associated with a longer duration of ARF. Quantitative analysis of Doppler spectra can be helpful in the identification of patients at risk for rejection and in the timing of allograft biopsy during ARF. Persistently short Tmax values on the fifth day after transplantation perform better in identifying grafts at risk of rejection than high RI values.
authors.affiliation: Clinical Vascular Laboratory, University Hospital St Radboud Nijmegen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Merkus
authors.forename: A J
authors.initials: AJ
authors.lastname: Hoitsma
authors.forename: W N
authors.initials: WN
authors.lastname: van Asten
authors.forename: R A
authors.initials: RA
authors.lastname: Koene
authors.forename: S H
authors.initials: SH
authors.lastname: Skotnicki
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D006084:Graft Rejection / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation / Q000009:adverse effects / Q000000981:diagnostic imaging* / Q000276:immunology*; D008722:Methods; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors; D014463:Ultrasonography; D014655:Vascular Resistance