[Levels of plasma proteins in patients with ene stage renal failure treated with peritoneal dialysis with an addition of furosemide to dialysis fluid].
This study aimed at evaluating an effect of repeated intraperitoneal furosemide administration on plasma proteins in patients with uremia given the drug to increase intermittent peritoneal dialysis efficiency. Patients (n = 6) dialysed for 48-60 hours per week furosemide was added to dialysis fluid in the dose of 1.2-2.0 g per 1 dialysis weekly for 3 months. A control group consisted of patients (n = 6) dialysed without furosemide. Plasma total proteins, albumin, total globulins, IgG, and IgA were determined in all patients. At the same time, plasma furosemide levels were monitored. A 3-month treatment with dialyses supplemented with furosemide decreased plasma protein levels especially IgG (p < 0.5) in comparison with dialyses without the drug. Furosemide plasma levels remained below ototoxic levels (over 50 micrograms/mL) during the treatment.
Grzegorzewska
A
A
Kliniki Nefrologii Instytutu Chorób Wewnetrznych AM im. K. Marcinkowskiego, Poznaniu.
Krzymański
M
M
Antoniewicz
K
K
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D005665:Furosemide / Q000008:administration & dosage* / Q000097:blood; D015312:Hemodialysis Solutions; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008875:Middle Aged; D010530:Peritoneal Dialysis
D001798:Blood Proteins; D015312:Hemodialysis Solutions; D005665:Furosemide
Stezenie białek w osoczu chorych na schyłkowa niewydolność nerek leczonych dializami otrzewnowymi z dodatkiem furosemidu do płynu dializacyjnego.