Antimicrobial agents from Heterotheca inuloides.
By bioassay directed fractionation, four sesquiterpenoids 1-4 were isolated as antimicrobial agents from the dried flowers of Heterotheca inuloides, a Mexican medicinal plant locally known as "arnica". 7-Hydroxy-3,4-dihydrocadalin (3) and 7-hydroxycadalin (4) exhibited potent antibacterial activity against Gram-positive bacteria with minimum inhibitory concentrations (MICs) ranging from 6.25 to 12.5 micrograms/ml. Notably, 7-hydroxy-3,4-dihydrocadalin showed bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum bactericidal concentration (MBC) of 12.5 micrograms/ml.
Kubo
I
I
Division of Environmental Science, Policy and Management, University of California, Berkeley 94720.
Muroi
H
H
Kubo
A
A
Chaudhuri
S K
SK
Sanchez
Y
Y
Ogura
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal
D000900:Anti-Bacterial Agents