title: The heme-copper oxidase family consists of three distinct types of terminal oxidases and is related to nitric oxide reductase.
abstract: Among aerobic prokaryotes, many different terminal oxidase complexes have been described. Sequence comparison has revealed that the aa3-type cytochrome c oxidase and the bo3-type quinol oxidase are variations on the same theme: the heme-copper oxidase. A third member of this family has recently been recognized: the cbb3-type cytochrome c oxidase. Here we give an overview, and report that nitric oxide (NO) reductase, a bc-type cytochrome involved in denitrification, shares important features with these terminal oxidases as well. Tentative structural, functional and evolutionary implications are discussed.
authors.affiliation: Department of Molecular and Cellular Biology, BioCentrum Amsterdam, Vrije Universiteit, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van der Oost
authors.forename: A P
authors.initials: AP
authors.lastname: de Boer
authors.forename: J W
authors.initials: JW
authors.lastname: de Gier
authors.forename: W G
authors.initials: WG
authors.lastname: Zumft
authors.forename: A H
authors.initials: AH
authors.lastname: Stouthamer
authors.forename: R J
authors.initials: RJ
authors.lastname: van Spanning
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000145:classification*; D003300:Copper; D003576:Electron Transport Complex IV / Q000145:classification; D006420:Hemeproteins / Q000737:chemistry / Q000145:classification*; D008667:Metalloproteins / Q000737:chemistry / Q000145:classification*; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000737:chemistry / Q000145:classification*
chemical_list: D001426:Bacterial Proteins; D006420:Hemeproteins; D008667:Metalloproteins; D003300:Copper; D010088:Oxidoreductases; C020094:duroquinol oxidase; C034747:nitric-oxide reductase; D003576:Electron Transport Complex IV