Early morphometry of a retinal dystrophy in Labrador retrievers.
Retinal morphometry was assessed in 7 dogs from a colony of Labrador Retrievers with dystrophic retinas at 1,2,3,4 and 18 months of age. Rod outer segment length and outer nuclear layer width were measured in the central, midperipheral and peripheral retina at six locations along the vertical meridian. Early striking regional differences in onset and rate of progression were characteristic for this inherited retinal degeneration. Notably, some areas of the retina developed fully and normally before degenerating. The central parts of the vertical meridians showed slightly disorganized rod outer segments already at 1 month of age and they were significantly shorter than those of control animals at 3 and 4 months (p < 0.01 and p < 0.001, respectively). The rod outer segments of the midperipheral and peripheral regions were, however, comparable to control animals as late as at 4 months of age. At 18 months the rod outer segments of dystrophic animals were significantly shorter in all retinal regions (p < 0.0005). At the age the outer nuclear layer of the dystrophic animals had become significantly thinner than that of control animals in all retinal regions (p < 0.001), indicating a clear visual cell loss. It is reasonable to characterize this as a retinal degeneration having a relatively slow progression, which enhances its relevance to conditions of clinical significance.
Kommonen
B
B
Department of Surgery and Anatomy, College of Veterinary Medicine, Helsinki, Finland.
Penn
J S
JS
Kylmä
T
T
Karhunen
U
U
Dawson
W W
WW
Tolman
B
B
Ukkola
T
T
D000375:Aging / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D010375:Pedigree; D012162:Retinal Degeneration / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D012374:Rod Cell Outer Segment / Q000473:pathology