Loss of heterozygosity in ovarian cancer: detection by PCR and microsatellite polymorphism.
Loss of chromosome 6q was investigated in endometrial and ovarian carcinomas by a PCR based-microsatellite polymorphism analysis. Results obtained show that this technique is able to detect frequent loss of heterozygosity in the ovarian cancers (10/27) and only in the serous type (8/17). Then, this kind of analysis can contribute to the understanding of tumor development and progression of ovarian cancers with different histopathological features.
Aguiari
G L
GL
Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara.
Bianchi
N
N
Cavazzini
P
P
Martinello
R
R
Lovato
F
F
Mollica
G
G
Piva
R
R
del Senno
L
L
D001483:Base Sequence; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm; D004276:DNA, Satellite; D005260:Female; D006579:Heterozygote; D006801:Humans; D008969:Molecular Sequence Data; D010051:Ovarian Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics
D017931:DNA Primers; D004273:DNA, Neoplasm; D004276:DNA, Satellite; D011960:Receptors, Estrogen