Carcinogenic evaluation of 2,3-dimethyl-2,3-dinitrobutane via the mouse skin bioassay.
Female SENCAR mice initiated with 2,3-dimethyl-2,3-dinitrobutane (DMDNB) and promoted with 12-O-tetradecanoylphorol-13-acetate (TPA) via the SENCAR mouse skin bioassay did not exhibit a significant increase in skin tumors. The mice received 20 mg kg-1 DMDNB divided into six intragastric doses over 2 weeks and were promoted three times per week for 20 weeks.
Reddy
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Environmental Monitoring Systems Laboratory, US Environmental Protection Agency, Cincinnati, Ohio 45268.
Olson
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Daniel
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Robinson
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D000818:Animals; D002073:Butanes / Q000633:toxicity*; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced
D002073:Butanes; D002273:Carcinogens; C089312:2,3-dimethyl-2,3-dinitrobutane