title: Lymphatic absorption of enterally fed structured triacylglycerol vs physical mix in a canine model.
abstract: The lymphatic absorption of a structured triacylglycerol vs an equivalent physical mixture of the constituent medium-chain triacylglycerol and fish oils was studied. Each of four canines served as its own control in a crossover feeding design with the investigators unaware of diet contents. Lymphatic absorption of n-3 and medium-chain fatty acids peaked within 4-8 h of feeding either diet. The lymph contained more 10:0 fatty acids than 8:0 despite an overall ratio of 10:0 to 8:0 of 0.3 for the diets. The mass of medium-chain fatty acids absorbed in the lymph at measured time points was 2.6 +/- 0.5-fold higher (mean +/- SE of 12 determinations) for the structured triacylglycerol compared with the physical mix. Molecular species analyses revealed that the medium-chain fatty acids in lymph were present as mixed triacylglycerols. The unique molecular structure of these mixed triacylglycerols and the fatty acids at the 2-position may account for the improved absorption.
authors.affiliation: Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, PA 17822.
authors.forename: G L
authors.initials: GL
authors.lastname: Jensen
authors.forename: N
authors.initials: N
authors.lastname: McGarvey
authors.forename: R
authors.initials: R
authors.lastname: Taraszewski
authors.forename: S K
authors.initials: SK
authors.lastname: Wixson
authors.forename: D L
authors.initials: DL
authors.lastname: Seidner
authors.forename: T
authors.initials: T
authors.lastname: Pai
authors.forename: Y Y
authors.initials: YY
authors.lastname: Yeh
authors.forename: T W
authors.initials: TW
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: DeMichele
mesh_terms: D000042:Absorption; D000818:Animals; D004285:Dogs; D004750:Enteral Nutrition; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008208:Lymphatic System / Q000378:metabolism*; D014280:Triglycerides / Q000008:administration & dosage* / Q000032:analysis / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D014280:Triglycerides