Dopa responsive dystonia with diurnal fluctuation (Segawa's syndrome).
A 10-year-old girl presented with progressive dystonia with diurnal fluctuation. Response to low dose L-Dopa was dramatic and sustained with no complications. Recurrence of symptoms was observed on attempted withdrawal. Because of the dramatic response to therapy, dopa-responsive dystonia must be considered in the differential diagnosis of disorders presenting as gait disorders in childhood.
Ong
L C
LC
Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur.
Tang
S F
SF
Lal
T R
TR
D002648:Child; D002940:Circadian Rhythm; D003937:Diagnosis, Differential; D004421:Dystonia / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*
D007980:Levodopa