Effects of territrem-B on cholinergic responses of snail neuron.
Effects of territrem-B (TRB), a mycotoxin isolated from a rice culture of Aspergillus terreus, on the central neuron of the snail Achatina fulica were studied electrophysiologically. Territrem-B potentiated the acetylcholine (ACh) induced current of the neuron, while it had no effect on GABA or L-glutamate elicited currents. TRB and neostigmine increased the peak amplitude of the response elicited by the first perfusion of ACh and depressed the increase in current produced by a second perfusion. TRB and neostigmine showed different dose-dependent effects on ACh responses. The results suggested that TRB is a good tool for studying the physiological role of AChE in central neurons.
Arvanov
V L
VL
Department of Pharmacology and Neurology, College of Medicine, National Taiwan University, Taipei, ROC.
Ling
K H
KH
Chen
R C
RC
Tsai
M C
MC
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D009388:Neostigmine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D011714:Pyrans / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D005971:Glutamates; D011714:Pyrans; D009388:Neostigmine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C040405:territrem B; D000109:Acetylcholine