Polymorphism in Plasmodium vivax MSA1 gene--the result of intragenic recombinations?
The diversity in a 925 bp portion of the Plasmodium vivax MSA1 gene in isolates from the Philippines, China, the Solomon Islands and Papua New Guinea was investigated. A total of 74 base pair changes was found in the amplified fragment from 18 isolates. Most of these changes were single or double base pair substitutions. In several regions, these point changes were tightly linked with one set always present or always absent in the different isolates. Seven such blocks were identified. These blocks were present in different combinations in the different isolates indicating that extensive intragenic recombination has occurred.
Cheng
Q
Q
Queensland Institute of Medical Research, Brisbane, Australia.
Stowers
A
A
Huang
T Y
TY
Bustos
D
D
Huang
Y M
YM
Rzepczyk
C
C
Saul
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002681:China / Q000453:epidemiology; D003001:Cloning, Molecular; D017125:Genes, Protozoan / Q000235:genetics*; D006801:Humans; D008542:Melanesia / Q000453:epidemiology; D020066:Merozoite Surface Protein 1; D008969:Molecular Sequence Data; D010219:Papua New Guinea / Q000453:epidemiology; D010679:Philippines / Q000453:epidemiology; D010966:Plasmodium vivax / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011498:Protein Precursors / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D020066:Merozoite Surface Protein 1; D011498:Protein Precursors; D015800:Protozoan Proteins