HLA-type of cerebral vasospasm patients after aneurysmal subarachnoid hemorrhage.
We studied human lymphocyte antigen (HLA) types in a group of 45 patients who had aneurysmal subarachnoid hemorrhage (SAH). A significantly increased frequency of HLA antigen A31 and a significantly decreased frequency of HLA antigen B40 were found. In patients with delayed ischemic neurological deficit (DIND) following aneurysmal SAH and HLA typing, HLA-Bw60 antigen showed significant increases; in patients who did not develop HLA-Aw33 and -Cw4 antigens showed significant. Among the patients with Fisher's Group 3 on CT, in particular, these antigens significantly increased when compared with controls from the same geographic area. These results suggest that HLA-Bw60 antigen plays a role as predisposing factor of DIND resulting from vasospasm following aneurysmal SAH, and that HLA-Aw33 and -Cw4 exert protective influence against DIND.
Sakaguchi
J
J
Department of Neurosurgery, Tokyo Women's Medical College, Japan.
Takeshita
M
M
Kagawa
M
M
Izawa
M
M
Takakura
K
K
D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000150:complications; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D059947:HLA-B40 Antigen; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000150:complications*
D006680:HLA Antigens; D015234:HLA-A Antigens; C082945:HLA-A*33 antigen; C069527:HLA-A31 antigen; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; C081918:HLA-B60 antigen; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen