title: Comparative effects of chronic administration of some psychotropic drugs on rat brain cortex acetylcholinesterase activity.
abstract: The response of central cholinergic neurotransmission to the chronic administration of some psychotropic drugs to rats was investigated using brain acetylcholinesterase activity as a neurochemical marker for cholinergic neurons. Rats were divided into four groups. Three experimental groups were given chlorpromazine, amitriptyline, or diazepam respectively, for a period of 30 days; and the control group received physiological saline only. Long-term treatment of chlorpromazine and amitriptyline resulted in significant increases in rat brain cortex enzyme activity, whereas only a slight increase was observed in the diazepam-treated group. These results indicate that the chronic treatment with some psychotropic drugs causes changes in central cholinergic transmission.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Bekpinar
authors.forename: P
authors.initials: P
authors.lastname: Oner
authors.forename: F G
authors.initials: FG
authors.lastname: Eryürek
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D015415:Biomarkers; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology*; D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D015415:Biomarkers; D011619:Psychotropic Drugs; D000639:Amitriptyline; D000110:Acetylcholinesterase; D003975:Diazepam; D002746:Chlorpromazine