title: Analysis of polycystic kidney disease with two new microsatellite markers.
abstract: Two (CA) microsatellite polymorphisms have been studied in 209 subjects from Northern Italy, members of 27 Polycystic Kidney Disease families. Polymorphic alleles were analyzed by using a labelled PCR. Results obtained show that these markers highly improve the presymptomatic diagnosis of the disease in subjects at risk. In addition, our findings suggest that a region with a high recombination frequency should exist between PKD1 and SM7.
authors.affiliation: Dipartimento di Biochimica e Biologia Molecolare, Universitá degli Studi di Ferrara.
authors.forename: A
authors.initials: A
authors.lastname: Bozza
authors.forename: S
authors.initials: S
authors.lastname: Stefani
authors.forename: E
authors.initials: E
authors.lastname: De Paoli Vitali
authors.forename: L
authors.initials: L
authors.lastname: Perini
authors.forename: L
authors.initials: L
authors.lastname: del Senno
mesh_terms: D001483:Base Sequence; D002885:Chromosomes, Human, Pair 16; D004247:DNA / Q000032:analysis; D017931:DNA Primers / Q000737:chemistry; D004276:DNA, Satellite; D004591:Electrophoresis, Polyacrylamide Gel; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D010375:Pedigree; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D016133:Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D004276:DNA, Satellite; D005819:Genetic Markers; D004247:DNA