Tremor-bursts induced by a combined application of chlorpromazine and pentobarbital in guinea pigs are asymmetrically influenced by right- and left-brain lesions.
The effect of right- and left-brain lesions on pentobarbitone-chlorpromazine induced tremor-bursts was studied in guinea pigs. The left-brain transections did not affect these tremor bursts except post-thalamic sections, which caused a complete disappearance of extensor jerks with coinciding tremors at four legs. These tremor bursts simultaneously occurring at four legs completely disappeared after a right-forebrain transection at the level of the rostral striatum. Extensor jerks without tremors continued to occur, however. It is concluded that the postural system is asymmetrically controlled and the rostral right brain is responsible for the tonic postural activity in guinea pigs.
Tan
U
U
Atatürk University, Medical Faculty, Department of Physiology, Erzurum, Turkey.
Kutlu
N
N
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology*; D004338:Drug Combinations; D007839:Functional Laterality; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D010424:Pentobarbital / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011187:Posture; D016548:Prosencephalon / Q000601:surgery; D014202:Tremor / Q000139:chemically induced*
D004338:Drug Combinations; D010424:Pentobarbital; D002746:Chlorpromazine