title: Loss of heterozygosity in ovarian cancer: detection by PCR and microsatellite polymorphism.
abstract: Loss of chromosome 6q was investigated in endometrial and ovarian carcinomas by a PCR based-microsatellite polymorphism analysis. Results obtained show that this technique is able to detect frequent loss of heterozygosity in the ovarian cancers (10/27) and only in the serous type (8/17). Then, this kind of analysis can contribute to the understanding of tumor development and progression of ovarian cancers with different histopathological features.
authors.affiliation: Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara.
authors.forename: G L
authors.initials: GL
authors.lastname: Aguiari
authors.forename: N
authors.initials: N
authors.lastname: Bianchi
authors.forename: P
authors.initials: P
authors.lastname: Cavazzini
authors.forename: R
authors.initials: R
authors.lastname: Martinello
authors.forename: F
authors.initials: F
authors.lastname: Lovato
authors.forename: G
authors.initials: G
authors.lastname: Mollica
authors.forename: R
authors.initials: R
authors.lastname: Piva
authors.forename: L
authors.initials: L
authors.lastname: del Senno
mesh_terms: D001483:Base Sequence; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm; D004276:DNA, Satellite; D005260:Female; D006579:Heterozygote; D006801:Humans; D008969:Molecular Sequence Data; D010051:Ovarian Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics
chemical_list: D017931:DNA Primers; D004273:DNA, Neoplasm; D004276:DNA, Satellite; D011960:Receptors, Estrogen