In-vitro synthesis of antibodies to Toxoplasma gondii by lymphocytes from HIV-1-infected patients.
Toxoplasma-specific in-vitro antibody production by peripheral blood lymphocytes (PBL) was investigated in 124 adults infected with human immunodeficiency virus (HIV-1). PBL from 20 of 21 patients with cerebral toxoplasmosis showed spontaneous in-vitro secretion of antibodies to Toxoplasma gondii antigens. Among 103 HIV-1-infected patients without signs or symptoms of toxoplasmosis, PBL from 19 produced toxoplasma-specific antibodies in vitro; 5 of these patients, who discontinued prophylaxis for toxoplasmic encephalitis, showed in-vitro antibody production 3-15 months before the diagnosis of toxoplasmic encephalitis. In-vitro production of toxoplasma-specific antibodies could improve the diagnosis of toxoplasmic encephalitis in HIV-1-infected patients.
Vendrell
J P
JP
Department of Immunology, INSERM unit 249, Institut de Biologie, Montpellier, France.
Reynes
J
J
Huguet
M F
MF
Ngou
J
J
Michard
C
C
Atoui
N
N
Pratlong
F
F
Segondy
M
M
Serre
A
A
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000276:immunology; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis*; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D015497:HIV-1; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014122:Toxoplasma / Q000276:immunology*; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis / Q000276:immunology
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan