Urinary growth hormone in growth-impaired children with chronic inflammatory bowel disease.
Growth impairment of undefined aetiology occurs in approximately 30% of children with chronic inflammatory bowel disease. We measured urinary growth hormone concentrations in 36 children with chronic inflammatory bowel disease and 51 normal controls. The median urinary concentration of growth hormone in the stunted children with chronic inflammatory bowel disease was 15.8 ng/g creatinine (range 4.3-32.6), compared with 11.7 ng/g creatinine (range 4.1-35.9) in those with normal growth. The difference was statistically not significant (p = 0.15). Moreover, there was no significant difference between the patients and the control group. One stunted patient had a urinary growth hormone (UGH) concentration below the normal range, whereas four patients with normal height were also below the normal range. Four of these five patients (80%) were on corticosteroid treatment at the time of urinary collection, whereas only 26% of the patients with normal UGH were also on corticosteroid treatment. We conclude that growth retardation in children with chronic inflammatory bowel disease is probably not related to growth hormone deficiency but must involve other mechanisms.
Braegger
C P
CP
Department of Paediatric Gastroenterology, St. Bartholomew's Hospital, London, England.
Torresani
T
T
Murch
S H
SH
Savage
M O
MO
Walker-Smith
J A
JA
MacDonald
T T
TT
D000293:Adolescent; D000636:Aminosalicylic Acids / Q000627:therapeutic use; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy / Q000652:urine*; D003404:Creatinine / Q000652:urine; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005183:Failure to Thrive; D005260:Female; D006130:Growth Disorders / Q000150:complications / Q000652:urine*; D013006:Growth Hormone / Q000652:urine*; D006801:Humans; D008297:Male; D019804:Mesalamine; D011239:Prednisolone / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use
D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine; D013006:Growth Hormone; D011239:Prednisolone; D003404:Creatinine