Urinary excretion of hexafluoroisopropanol glucuronide and fluoride in patients after sevoflurane anaesthesia.
The excretion of sevoflurane metabolites in the urine collected every 12 h after sevoflurane anaesthesia was measured by ion exchange chromatography. A metabolite, which was converted on incubation with glucuronidase to hexafluoroisopropanol was detected in the urine. The maximum excretion was found in the first 12 h after anaesthesia, none was found in the last collection 3 days after anaesthesia. The excretion half-life for the metabolite was calculated to be 55 h. A significant increase in the urinary excretion of organic and inorganic fluoride was also observed during the first 12 h after anaesthesia. The cumulative organic and inorganic fluoride excretion in the 3 days after sevoflurane anaesthesia was 1588 and 856 mumol, respectively (ratio = 1.85). The excreted half-lives for organic and inorganic fluoride were calculated to be 4028 and 2069 min, respectively. Our study showed that a hexafluoroisopropanol glucuronide is excreted in the urine, and the major part of urinary metabolites of sevoflurane, organic and inorganic fluoride, are excreted within 2 days of sevoflurane inhalation in man.
Ni
J
J
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Hiroshima University, Japan.
Sato
N
N
Fujii
K
K
Yuge
O
O
D000433:1-Propanol / Q000652:urine; D000328:Adult; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000493:pharmacokinetics*; D002852:Chromatography, Ion Exchange; D004987:Ethers / Q000493:pharmacokinetics*; D005459:Fluorides / Q000652:urine*; D005965:Glucuronates / Q000652:urine*; D005966:Glucuronidase / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008738:Methyl Ethers; D020005:Propanols; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D005965:Glucuronates; D008738:Methyl Ethers; D020005:Propanols; D000077149:Sevoflurane; D000433:1-Propanol; D005966:Glucuronidase; C079687:hexafluoroisopropanol glucuronide; D005459:Fluorides