[Clonidine in the treatment of tobacco withdrawal. A comparison with nicotine chewing gum].
The objective of our work was to carry out a prospective study on the effectiveness of clonidine and nicotine gum in the treatment of tobacco withdrawal. Sixty smokers were randomly distributed in two groups and were included in a tobacco withdrawal program. One group received oral clonidine treatment while the other group was given nicotine gum. Adjuvant therapy such as group therapy or psychotherapy was not performed. At the end of one year there were no significant differences between the two groups with regards to the number of subjects who have continued to stop smoking. There were also no significant differences between the two groups with regards to the symptoms of tobacco abstinence. When we studied the relation between treatment fulfillment and tobacco withdrawal we observed that the clonidine treated group had a significantly greater number of success compared to the nicotine group (p < 0.01).
Aparici
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Departamento de Cardiología y Cirugía Cardiovascular, Clínica Universitaria de Navarra, Pamplona.
Fernández González
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Alegría
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D000328:Adult; D002638:Chewing Gum; D003000:Clonidine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D016540:Smoking Cessation / Q000379:methods / Q000706:statistics & numerical data; D013030:Spain / Q000453:epidemiology; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000453:epidemiology; D014029:Tobacco Use Disorder / Q000188:drug therapy* / Q000453:epidemiology
D002638:Chewing Gum; D009538:Nicotine; D003000:Clonidine
Clonidina en el tratamiento de la deshabituación tabáquica. Comparación con chicles de nicotina.