Serological definition of bovine MHC class II polymorphism in Holstein-Friesians.
Analysis of the reaction patterns of 57 putative class II MHC alloantisera revealed 18 B-cell serum clusters, named Ds01-Ds18. These clusters were grouped together in such a manner that 17 provisional serological class II haplotypes were defined. Segregation in half-sib families of these class II haplotypes with serologically defined class I and 1D-IEF defined DRB3 types indicated that the 18 clusters identify class II polymorphisms in cattle and can be considered as local specificities.
Nilsson
P R
PR
Department of Animal Husbandry, Agricultural University, Wageningen, The Netherlands.
Schreuder
G M
GM
D'Amaro
J
J
Joosten
I
I
Buis
R C
RC
Davies
C J
CJ
van der Poel
J J
JJ
D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000276:immunology*; D005260:Female; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007525:Isoelectric Focusing / Q000662:veterinary; D008214:Lymphocytes / Q000276:immunology; D011110:Polymorphism, Genetic / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera