[RFLP analysis of Met and D7S23 loci, linked with the cystic fibrosis gene, in the populations of Bashkir and Komi].
The allelic polymorphism of MET and D7S23 loci closely linked to the cystic fibrosis gene was studied using polymerase chain reaction of DNA synthesis. Our studies failed to reveal any significant differences in the distribution of the allelic frequencies of these loci in the populations regarded. The distribution of the allelic frequencies of MET locus in Bashkir and Komi populations did not virtually differ from that in the populations of St. Petersburg and Kiev and those of North-West Europe and North America. Similarity in the distribution of allele frequencies between Bashkir, Komi, Lithuanian and Buryatian populations was observed for the D7S23 locus. At the same time, significant difference from the allelic frequencies for this locus was noted in populations of St. Petersburg and Azerbaijan. Genetic distances between the Bashkir and Komi populations under study were specified according to the data on the allelic frequencies of MET and D7S23 loci. Comparative analysis of these distances and those obtained on the basis of the allelic frequencies of biochemically polymorphic systems of AB0, Rh-Hr blood groups, haptoglobin protein (Hp) and the enzyme of acid erythrocyte phosphatase (AcP) was carried out as well.
Khidiiatova
I M
IM
Khusnutdinova
E K
EK
Ivashchenko
T E
TE
Rafikov
Kh S
KhS
D000135:Acid Phosphatase / Q000235:genetics; D001789:Blood Group Antigens / Q000235:genetics; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA; D004912:Erythrocytes / Q000201:enzymology; D005006:Ethnicity; D008040:Genetic Linkage; D006242:Haptoglobins / Q000235:genetics; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012426:Russia
D001789:Blood Group Antigens; D006242:Haptoglobins; D004247:DNA; D000135:Acid Phosphatase
PDRF-analiz lokusov MET i D7S23, stseplennykh s genom mukovistsidoza, v populiatsiiakh Bashkir i Komi.