Effects of intravenous superoxide dismutase and catalase on electroretinogram in the cat postischemic retina.
We examined the effects of the antioxidant enzymes, 10,000 U/kg of superoxide dismutase (SOD) and 50,000 U/kg of catalase (CAT) on cat electroretinograms during the reperfusion after retinal ischemia. The intravenous administrations of SOD and CAT promoted the recovery of the c-wave after 30 min of ischemia but not the b-wave. At 5 min after onset of reperfusion, SOD- and CAT-treated eyes showed 90 and 110% recovery of the c-wave amplitude respectively, against 50% recovery in the untreated eyes. These results suggested that the oxygen-derived free radicals affected the retinal pigment epithelium at the early period of reperfusion.
Yamamoto
F
F
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Hiroi
K
K
Honda
Y
Y
D000818:Animals; D002374:Catalase / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D004596:Electroretinography / Q000187:drug effects; D005609:Free Radicals; D007275:Injections, Intravenous; D007511:Ischemia / Q000503:physiopathology*; D010857:Pigment Epithelium of Eye / Q000502:physiology; D012160:Retina / Q000503:physiopathology*; D012171:Retinal Vessels / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000494:pharmacology*
D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase