title: Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.
abstract: K252c-related compounds were synthesized with different framework flexibilities and different functions (imide, amide and amide-alcohol) on the non-indolic heterocycle. The inhibitory activities towards protein kinase C and protein kinase A are compared.
authors.affiliation: Université Blaise Pascal, Laboratoire de Chimie Organique Biologique, URA 485, Aubière, France.
authors.forename: S
authors.initials: S
authors.lastname: Fabre
authors.forename: M
authors.initials: M
authors.lastname: Prudhomme
authors.forename: M
authors.initials: M
authors.lastname: Rapp
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D002227:Carbazoles; D026121:Indole Alkaloids; C049985:staurosporine aglycone; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C