The mouse lysyl oxidase gene (Lox) resides on chromosome 18.
Lysyl oxidase initiates crosslink formation of the connective tissue matrix. This enzyme can also revert the ras phenotype in mouse NIH 3T3-transformed cells. Even though lysyl oxidase may participate in many different biological processes, its chromosomal assignment in the mouse genome remains to be addressed. Southern analysis of a panel of Chinese hamster x mouse somatic cell hybrids was utilized to assign the lysyl oxidase gene (Lox) to mouse Chromosome 18.
Chang
Y S
YS
Center for Molecular Biology, Wayne State University, Detroit, MI.
Svinarich
D M
DM
Yang
T P
TP
Krawetz
S A
SA
D000818:Animals; D015139:Blotting, Southern; D006224:Cricetinae; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics*; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics*
D008249:Protein-Lysine 6-Oxidase