[Functional and morphological changes in the liver after hepatic resection].
Compensation of the functional condition of the liver after its resection is determined by the volume and structural changes of the remaining part of the organ and the injuriousness of the intervention rather than by the character of the affection; adequate and stable restoration of the function of the organ occurs in 12-18 months after extensive resections of the liver and in 2-4 months after economical resections. The parts of the liver remaining after extensive resection become sharply enlarged (by 100% and more) in the early postoperative period (up to 3 weeks) and then reduce gradually in 6-12 months to the size of the uninvolved parenchyma. In concurrent cirrhosis of the liver, complete restoration of the volume of the organ does not occur, the dynamics of the restoration of hepatic function is slowed down, and the terms of rehabilitation of the patients increase. Resection of the liver in humans is attended by marked activation of the processes of regeneration, which is manifested by hypertrophy of the cells and their nuclei, hyperplasia of the intracellular structures, providing for compensation of the disturbed functions of the organ. Removal of the pathological focus leads to abatement and disappearance of the inflammatory infiltration.
Vishnevskiĭ
V A
VA
Fedorov
V D
VD
Podkolzin
A V
AV
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
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