[Protective effect of sodium ferulate on damage of the rat liver mitochondria induced by oxygen free radicals].
This paper reports the protective effect of sodium ferulate (SF) on mitochondrial morphology and functions. Sodium ferulate was found to significantly inhibit the mitochondria abnormal swelling and TBA reaction induced by Fe2+/Vit C system. This compound was also shown to modulate the uncoupling effect of malondialdehyde (MDA) on oxidative phosphorylation of mitochondria. Respiratory control rate for blank, MDA and MDA+SF were 4.75, 3.64 and 4.50 respectively. SF was shown to inhibit the cross reaction of MDA with biological macromolecules of rat liver mitochondria assayed by SDS-polyacrylamide gel electrophoresis. The results suggest that the injury action of oxygen free radicals to rat liver mitochondria can be prevented by SF.
Lin
Y H
YH
Central Laboratory, Beijing College of Traditional Chinese Medicine.
Zhang
J J
JJ
Chen
W W
WW
D000818:Animals; D003373:Coumaric Acids / Q000494:pharmacology*; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D008315:Malondialdehyde; C004999:ferulic acid