Syntheses and biological activities of chemically stable prostacyclin mimics with cis-bicyclo[4.3.0]nonene ring system: the novel homoisocarbacyclin analogues.
The synthetic studies concerning a series of homoisocarbacyclin analogues, which are homologous compounds of isocarbacyclin, with cis-bicyclo[4.3.0]non-2-ene or cis-bicyclo[4.3.0]non-3-ene as a nucleus have been carried out. The general synthetic methods of homoisocarbacyclin analogues have been accomplished starting with the versatile Corey lactone. Among the analogues synthesized in the present studies, a promising compound (TY-11223) exhibiting a good selectivity in biological actions was found to be studied further.
Narita
S
S
Fukushima Research Laboratories, TOA EIYO Ltd., Japan.
Takahashi
A
A
Aoki
T
T
Sato
H
H
Satoh
S
S
Yamada
S
S
Kudo
M
M
Yamaguchi
T
T
Kogi
K
K
Shibasaki
M
M
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004285:Dogs; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared
D000897:Anti-Ulcer Agents; D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors; C061099:homoisocarbacyclin; C074379:TY 11223; D011464:Epoprostenol