[An experimental study of treatment with superoxide dismutase for alkali burn in the anterior segment of the rabbit eye].
The level of malondialdehyde (MDA) increased and the activity of superoxide dismutase (SOD) decreased significantly in the aqueous humor 4, 24, and 72 hours after alkali burn in the anterior segment of the rabbit eye. The level of MDA decreased and the activity of SOD increased significantly after subconjunctival injection of exogenous SOD, and the two were negatively correlated. The results suggest that alkali burn causes disturbances in reaction to free radicals, which may be controlled by an early supply of exogenous SOD.
Yuan
H P
HP
Department of Ophthalmology, Second Teaching Hospital, Harbin Medical-University.
Lu
S R
SR
Wang
B L
BL
D000468:Alkalies; D000818:Animals; D000869:Anterior Eye Segment / Q000293:injuries*; D002057:Burns, Chemical / Q000188:drug therapy*; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D000468:Alkalies; D013482:Superoxide Dismutase