Allele frequencies of Mp6D-9 and GATT markers in 32 Turkish cystic fibrosis families.
The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the delta F508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.
Ozgüç
M
M
Department of Medical Biology, Hacettepe University School of Medicine, Ankara, Turkey.
Yilmaz
E
E
Erdem
H
H
Coşkun
T
T
Ozçelik
U
U
Togan
I
I
Göçmen
A
A
Ayter
S
S
Ozalp
I
I
D000483:Alleles; D001483:Base Sequence; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D014421:Turkey
D005819:Genetic Markers; D004247:DNA