title: [Diffuse aspiration bronchiolitis (DAB) produced in animals by repeated HCl microaspiration].
abstract: We recently reported that diffuse aspiration bronchiolitis (DAB) was detected in 1% of autopsied lungs of aged cases of pneumonia. We hypothesized whether repeated HCl micro-aspiration (RHMA) is involved in DAB and established an animal model by administering HCl intratracheally to rats every two days for 2 weeks. Saline was given to control animals in the same fashion. Then, we performed bronchio-alveolar lavage (BAL) or excised lungs for histologic examination. There was no difference in BAL cell counts, TNF alpha-production, elastase-like activity or albumin levels between the HCl and control groups. Histologically, DAB-like findings were observed in the HCl-treated animals. These data suggest that RHMA might be involved in DAB, while neither TNF alpha-production nor elastase-like activity may play a significant role in inducing DAB.
authors.affiliation: Department of Geriatrics, Faculty of Medicine, University of Tokyo.
authors.forename: E
authors.initials: E
authors.lastname: Sudo
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: K
authors.initials: K
authors.lastname: Ishida
authors.forename: T
authors.initials: T
authors.lastname: Matsuse
authors.forename: T
authors.initials: T
authors.lastname: Nagase
authors.forename: S
authors.initials: S
authors.lastname: Teramoto
authors.forename: C
authors.initials: C
authors.lastname: Jo
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Higashimoto
authors.forename: T
authors.initials: T
authors.lastname: Oka
mesh_terms: D000818:Animals; D001988:Bronchiolitis / Q000209:etiology / Q000473:pathology*; D004195:Disease Models, Animal; D006851:Hydrochloric Acid / Q000008:administration & dosage*; D011015:Pneumonia, Aspiration / Q000209:etiology / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006851:Hydrochloric Acid