Intrastriatal injections of dynorphin A fragments potentiate the dorsal immobility response in rats.
The effects of bilateral intrastriatal injections (2.0 micrograms/side) of Dynorphin A 1-17 (Dyn A 1-17) and Dynorphin A 1-8 (Dyn A 1-8) and their related nonopioid fragments upon the dorsal immobility response (DIR) over a 1-h time course were investigated. Dyn A 1-17 and Dyn A 2-17 potentiated the duration of the DIR 5 min postinjection, whereas Dyn A 1-8 and Dyn A 2-8 potentiated the DIR duration at each time point over the hour with their greatest effect at 15 min. An SC injection of 4 mg/kg naloxone 15 min prior to central injections blocked the potentiation of the DIR effects of Dyn A.
Meyer
M E
ME
Department of Psychology, University of Florida, Gainesville 32611.
D000595:Amino Acid Sequence; D000818:Animals; D003342:Corpus Striatum; D004399:Dynorphins / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D008969:Molecular Sequence Data; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D010446:Peptide Fragments; D009270:Naloxone; D004399:Dynorphins; C026770:dynorphin (1-8)