A 'pneumotaxic centre' in rats.
Electrical and chemical lesions in the ventrolateral pons produced apneustic breathing in anesthetized, vagotomized, paralyzed, ventilated adult rats (n = 13). Apneustic breathing did not develop if the vagi remained intact and was reversed partially with vagal (proximal end) stimulation. Physiologically, these data are similar to those obtained following dorsolateral pontine lesion in rat and other mammalian species and support the hypothesis that pontine neurons influence breathing similarly across mammalian species.
Jodkowski
J S
JS
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-5000.
Coles
S K
SK
Dick
T E
TE
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010791:Phrenic Nerve / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011149:Pons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*; D014628:Vagotomy
D009118:Muscimol