title: Search for linkage to schizophrenia on the X and Y chromosomes.
abstract: Markers for X chromosome loci were used in linkage studies of a large group of small families (n = 126) with at least two schizophrenic members in one sibship. Based on the hypothesis that a gene for schizophrenia could be X-Y linked, with homologous loci on both X and Y, our analyses included all families regardless of the pattern of familial inheritance. Lod scores were computed with both standard X-linked and a novel X-Y model, and sib-pair analyses were performed for all markers examining the sharing of maternal alleles. Small positive lod scores were obtained for loci pericentromeric, from Xp11.4 to Xq12. Lod scores were also computed separately in families selected for evidence of maternal inheritance and absence of male to male transmission of psychosis. The lod score for linkage to the locus DXS7 reached a maximum of 1.83 at 0.08% recombination, assuming dominant inheritance on the X chromosome in these families (n = 34). Further investigation of the X-Y homologous gene hypothesis focussing on this region is warranted.
authors.affiliation: Department of Psychiatry, SUNY Stony Brook 11794.
authors.forename: L E
authors.initials: LE
authors.lastname: DeLisi
authors.forename: M
authors.initials: M
authors.lastname: Devoto
authors.forename: R
authors.initials: R
authors.lastname: Lofthouse
authors.forename: M
authors.initials: M
authors.lastname: Poulter
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Shields
authors.forename: N
authors.initials: N
authors.lastname: Bass
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Vita
authors.forename: C
authors.initials: C
authors.lastname: Morganti
mesh_terms: D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D012559:Schizophrenia / Q000235:genetics*; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D005819:Genetic Markers