title: Failure of neutrophils to recover their ability to produce superoxide after stunning by a conventional, acidic, lactate-based peritoneal dialysis solution.
abstract: Exposure of human neutrophils to conventional, acidic, lactate-based peritoneal dialysis solutions for 5 minutes results in a depression of superoxide generation. In spite of restoration of extracellular pH to 7.4, these stunned cells failed to recover their ability to generate the anion after a period of an hour.
authors.affiliation: Department of Medicine, Veterans Affairs Hospital, Hines, Illinois.
authors.forename: T S
authors.initials: TS
authors.lastname: Ing
authors.forename: A W
authors.initials: AW
authors.lastname: Yu
authors.forename: P V
authors.initials: PV
authors.lastname: Podila
authors.forename: F Q
authors.initials: FQ
authors.lastname: Zhou
authors.forename: E W
authors.initials: EW
authors.lastname: Kun
authors.forename: P
authors.initials: P
authors.lastname: Strippoli
authors.forename: Z M
authors.initials: ZM
authors.lastname: Nawab
mesh_terms: D000328:Adult; D015314:Dialysis Solutions / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010530:Peritoneal Dialysis; D013481:Superoxides / Q000378:metabolism*
chemical_list: D015314:Dialysis Solutions; D007773:Lactates; D013481:Superoxides