Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.
K252c-related compounds were synthesized with different framework flexibilities and different functions (imide, amide and amide-alcohol) on the non-indolic heterocycle. The inhibitory activities towards protein kinase C and protein kinase A are compared.
Fabre
S
S
Université Blaise Pascal, Laboratoire de Chimie Organique Biologique, URA 485, Aubière, France.
Prudhomme
M
M
Rapp
M
M
D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D002227:Carbazoles; D026121:Indole Alkaloids; C049985:staurosporine aglycone; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C