Maternal mild hyperphenylalaninemia: results of treated and untreated pregnancies in two sisters.
The outcomes of mild hyperphenylalaninemia (MHP) in three children of two sisters were compared. The IQ of the child from an untreated pregnancy was 105; the developmental quotients of the two infant offspring from treated and untreated pregnancies were 122 and 114, respectively. The IQ of the sister with untreated MHP was 101; that of the sister who received dietary treatment for MHP during infancy was 90. Thus MHP and maternal MHP appear to have been clinically inconsequential in this family.
Levy
H L
HL
Department of Nutrition and Medical Dietetics, University of Illinois at Chicago.
Goss
B S
BS
Sullivan
D K
DK
Michals-Matalon
K
K
Dobbs
J M
JM
Guldberg
P
P
Güttler
F
F
D000328:Adult; D002657:Child Development; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence / Q000235:genetics; D008297:Male; D010649:Phenylalanine / Q000097:blood* / Q000235:genetics; D010661:Phenylketonurias / Q000097:blood / Q000178:diet therapy / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications
D010649:Phenylalanine