[Lipid metabolic disorders and lipid peroxidation in patients with the nephrotic syndrome].
Lipid metabolism was studied in 161 patients with renal diseases, 62 of them had nephrotic syndrome (NS). The measurements were made of cholesterol, triglycerides, dienic conjugates, B2-microglobulins in urine and blood, functional and morphological parameters, red cell resistance to peroxide hemolysis. It was found that NS patients, especially those with additional renal failure, displayed high-intensity lipoperoxidation (LPO). LPO intensity proved unrelated to NS etiology. NS-associated hyperlipidemia gives rise to multifunctional biomembrane instability responsible for antioxidant disorders.
Shishkin
A N
AN
Kolmakova
E V
EV
Ashirova
K V
KV
D000328:Adult; D000975:Antioxidants; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood* / Q000209:etiology; D001613:beta 2-Microglobulin / Q000032:analysis
D000975:Antioxidants; D015415:Biomarkers; D008054:Lipid Peroxides; D008055:Lipids; D001613:beta 2-Microglobulin
Narusheniia lipidnogo obmena i perekisnoe okislenie lipidov u bol'nykh s nefroticheskim sindromom.