title: Activity of alpha-anilinobenzyl cyanides and 2-methoxycarbonylamino-1-phenylimidazoles, a new class of antifilarial agents.
abstract: The activity of alpha-anilinobenzyl cyanides (2a-f), 5-aryl-4,5-dihydro-2-methoxycarbonylamino-1-phenylimidazoles (5a-d) and 2-methoxycarbonylamino-1-phenyl-1,3-diazaspiro[4:5]dec-2-ene (5f) have been tested for their micro- and macrofilaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodents. In this test alpha-anilinobenzyl cyanides (2a-b), 5-(4-methoxyphenyl)-4,5-dihydro-2-methoxy-carbonylamino-1-phenylim idazole (5b) and 2-methoxycarbonylamino-1-phenyl-1,3-diazaspiro[4:5]dec-2-ene (5f) were found to possess marked filaricidal activity at doses ranging from 3-100 mg/kg given parenterally or orally for 5 days.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India.
authors.forename: S S
authors.initials: SS
authors.lastname: Naim
authors.forename: V
authors.initials: V
authors.lastname: Srivastava
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: S N
authors.initials: SN
authors.lastname: Singh
authors.forename: N
authors.initials: N
authors.lastname: Fatima
authors.forename: R K
authors.initials: RK
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D003486:Cyanides / Q000138:chemical synthesis* / Q000627:therapeutic use; D004153:Dipetalonema; D004154:Dipetalonema Infections / Q000188:drug therapy* / Q000469:parasitology; D004353:Drug Evaluation, Preclinical; D005369:Filaricides / Q000138:chemical synthesis* / Q000627:therapeutic use; D005370:Filarioidea; D007093:Imidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D016205:Sigmodontinae / Q000469:parasitology*
chemical_list: D003486:Cyanides; D005369:Filaricides; D007093:Imidazoles