Nance-Horan syndrome: linkage analysis in a family from The Netherlands.
Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp.
Bergen
A A
AA
The Netherlands Ophthalmic Research Institute, Amsterdam.
ten Brink
J
J
Schuurman
E J
EJ
Bleeker-Wagemakers
E M
EM
D000015:Abnormalities, Multiple / Q000235:genetics*; D002386:Cataract / Q000235:genetics*; D004423:Ear / Q000002:abnormalities*; D005260:Female; D005808:Genes, Recessive; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008297:Male; D008540:Meiosis; D008850:Microphthalmos / Q000235:genetics*; D009426:Netherlands; D010375:Pedigree; D013577:Syndrome; D014071:Tooth Abnormalities / Q000235:genetics*; D014960:X Chromosome