Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
A new cancer cell line (Lu-165) producing a large amount of anti-diuretic hormone (ADH, 2.8 micrograms/g protein) was established from a 50-year-old small cell lung cancer patient presenting with a syndrome of inappropriate anti-diuretic hormone secretion. These cells grew well in serum-supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH-producing cancer.
Terasaki
T
T
Pathology Division, National Cancer Center Hospital, Tokyo.
Matsuno
Y
Y
Shimosato
Y
Y
Yamaguchi
K
K
Ichinose
H
H
Nagatsu
T
T
Kato
K
K
D000818:Animals; D018288:Carcinoma, Small Cell / Q000378:metabolism* / Q000648:ultrastructure; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured; D014667:Vasopressins / Q000096:biosynthesis*
D014667:Vasopressins