title: How would you manage extensive squamous cell carcinoma of the perineum?
abstract: Summary of the Case presented in full in the June issue (Eur J Surg Oncol 1994; 20: 248-50). A 57-year-old woman presented in December 1990 with an 8-cm warty lesion involving the whole perineum and adjacent vagina and anal canal. She had a history of carcinoma cervix uteri treated by abdominal hysterectomy 23 years earlier. Biopsies (x 3) showed the lesion to be a squamous cell carcinoma-in-situ with a thickness and depth of penetration at least suggestive of invasive cancer but no clear evidence of invasion. The initial decision at a joint clinic was that she be treated by radiotherapy, but that further biopsies be taken before a final decision. Examination under anaesthetic confirmed that the tumour was mobile on underlying tissues. Further biopsies (x 6) confirmed a diagnosis of extensive carcinoma in situ, but again showed no definite evidence of invasion.
mesh_terms: D002278:Carcinoma in Situ / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D010502:Perineum