A comparison of the incorporation of model steroids into non-ionic micellar and microemulsion systems.
The incorporation of testosterone and two of its esters, and progesterone and one of its esters (log Poct varying from 3.3 to 6.9) into 2% w/w soybean oil/Brij 96 microemulsions and Brij 96 surfactant systems has been examined. Possible sites of incorporation have been investigated. The drug carrying improvement of an oil-in-water microemulsion over a micellar system appears to depend on the solubility of the drug in the dispersed oil phase and is significant only for very lipophilic drugs.
Malcolmson
C
C
Department of Pharmacy, King's College London, UK.
Lawrence
M J
MJ
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004655:Emulsions; D008823:Micelles; D010938:Plant Oils; D011092:Polyethylene Glycols; D011374:Progesterone / Q000737:chemistry; D012995:Solubility; D013024:Soybean Oil; D013256:Steroids / Q000737:chemistry*; D013739:Testosterone / Q000737:chemistry
D004655:Emulsions; D008823:Micelles; D010938:Plant Oils; D013256:Steroids; D011092:Polyethylene Glycols; D013739:Testosterone; D011374:Progesterone; D013024:Soybean Oil; C033084:polyethylene glycol oleyl ether