Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia.
The cytokine macrophage migration inhibitory factor (MIF) is a major protein constituent of the anterior pituitary gland released into the bloodstream during endotoxaemia. For many years, MIF had been thought to be a T cell product associated with delayed-type hypersensitivity reactions. The identification of MIF as a pituitary 'stress' hormone provides an important link in the regulation of systemic inflammatory responses by the central nervous system.
Bernhagen
J
J
Picower Institute for Medical Research, Manhasset, NY 11030.
Calandra
T
T
Cerami
A
A
Bucala
R
R
D000818:Animals; D001424:Bacterial Infections / Q000097:blood / Q000378:metabolism*; D004731:Endotoxins / Q000097:blood*; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D010902:Pituitary Gland / Q000378:metabolism*
D004731:Endotoxins; D008263:Macrophage Migration-Inhibitory Factors