title: Fluorophotometry in myopic phakic eyes with anterior chamber intraocular lenses to correct severe myopia.
abstract: Implanting an anterior chamber intraocular lens in a phakic eye is an effective surgical procedure for the correction of severe myopia. However, the potential risks on the anterior segment structures are scarcely known. We conducted a prospective study to evaluate the permeability of the blood-aqueous barrier and the lens transmittance changes after Worst-Fechner lenses were implanted to correct myopia. Preoperative and serial postoperative fluorophotometry was done in 15 eyes that had a Worst-Fechner lens implanted to correct myopia. Lens transmittance was evaluated by lens autofluorescence, and permeability of the blood-aqueous barrier was estimated by anterior vitreous fluorophotometry, which was carried out before and after intravenous injection of fluorescein. Preoperative lens transmittance was 0.971 +/- 0.002 (mean +/- standard error), and, after the operation, lens transmittance decreased to 0.970 +/- 0.002 at one month, 0.966 +/- 0.001 at three months, 0.964 +/- 0.002 at six months, and 0.962 +/- 0.003 at 14 months. At three, six, and 14 months after the operation, lens transmittance values were significantly lower than preoperative values (P = .038 at three months, P < .001 at six months, and P = .005 at 14 months). Fluorescein concentration in the anterior vitreous was 18.522 +/- 1.797 ng/ml (mean +/- standard error) preoperatively and was 21.328 +/- 1.667 ng/ml at one month, 27.518 +/- 1.412 ng/ml at three months, 27.150 +/- 1.474 ng/ml at six months, and 27.012 +/- 1.980 ng/ml at 14 months postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Ophthalmology, Jiménez-Díaz Foundation, Autonomous University of Madrid School of Medicine, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Pérez-Santonja
authors.forename: J L
authors.initials: JL
authors.lastname: Hernández
authors.forename: J M
authors.initials: JM
authors.lastname: Benítez del Castillo
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez-Bermejo
authors.forename: M A
authors.initials: MA
authors.lastname: Zato
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000601:surgery*; D001082:Aqueous Humor / Q000378:metabolism; D001693:Biological Transport, Active; D002199:Capillary Permeability; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D015590:Fluorophotometry; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies
chemical_list: D005452:Fluoresceins; D019793:Fluorescein