title: Renal pathology and the 99mTc-DMSA image before and after treatment of the evolving pyelonephritic scar: an experimental study.
abstract: This study reports the effects of 3-weeks' antimicrobial treatment on the pathology and appearance of the 99mTc-DMSA renal image in piglets with pyelonephritis induced by a combination of vesicoureteral reflux (VUR) and urinary infection. Before treatment, either photon-deficient (B1, B2) or photon-absent (C) scintigraphic abnormalities were present in the refluxing kidney in all 22 animals examined. All (100%) of the initially B1 and the majority (71%) of B2 photon deficient defects resolved with treatment, leaving only insignificant residual pathologic lesions. Conversely almost all (93%) of the C photon-absent scintigraphic abnormalities persisted after treatment and were always associated with significant scarred or cratered pathologic lesions in the refluxing kidney at sacrifice.
authors.affiliation: Institute of Child Health, London, United Kingdom.
authors.forename: R A
authors.initials: RA
authors.lastname: Risdon
authors.forename: M L
authors.initials: ML
authors.lastname: Godley
authors.forename: I
authors.initials: I
authors.lastname: Gordon
authors.forename: P G
authors.initials: PG
authors.lastname: Ransley
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000000981:diagnostic imaging* / Q000209:etiology*; D007668:Kidney / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D011704:Pyelonephritis / Q000150:complications*; D011877:Radionuclide Imaging; D004113:Succimer; D013552:Swine; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer