title: Uncomplicated peptic ulcer disease. An overview of formation and treatment principles.
abstract: The end point in peptic ulcer disease is a crater in the mucosa. The cause of gastric ulcers seems to be the breakdown of defensive factors, which then allows damage from endogenous and/or exogenous aggressive factors. Aggressive factors are more important in duodenal ulcer formation. Treatment options discussed herein have similar clinical effectiveness, and all have better results than placebo. Selection of a specific agent should be individualized. Helicobacter pylori infection has been implicated in both gastric and duodenal ulcer formation, and use of triple-drug therapy to eradicate or suppress the organism has decreased recurrence rates when maintenance therapy is not used. However, first-line treatment in acute peptic ulcer disease remains the use of antacids, sucralfate (Carafate), or histamine2 receptor antagonists. This approach to therapy is inexpensive, safe, and effective.
authors.affiliation: Gastroenterology Division, University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: S A
authors.initials: SA
authors.lastname: Ziller
authors.forename: C V
authors.initials: CV
authors.lastname: Netchvolodoff
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D011453:Prostaglandins / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use*; D012008:Recurrence; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic