An interaction between Gemfibrozil and alpha 1-antitrypsin.
Previous studies have demonstrated such hydrophobic compounds as cholesterol and lithocholic acid, to interact with alpha 1-antitrypsin (alpha 1-AT). We observed a similar interaction between the anionic, hydrophobic lipid-lowering drug Gemfibrozil and alpha 1-AT in a deficient (PiZZ) patient, affecting the physicochemical and antiproteinase properties of the inhibitor protein. Gemfibrozil treatment in non-PiZ patients also resulted in a reduction of alpha 1-AT activity which could be reproduced in vitro.
Janciauskiene
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Lund University, Department of Medicine, Malmö General Hospital, Sweden.
Eriksson
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D004347:Drug Interactions; D015248:Gemfibrozil / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D000515:alpha 1-Antitrypsin / Q000494:pharmacology* / Q000627:therapeutic use
D000515:alpha 1-Antitrypsin; D015248:Gemfibrozil