[Anti-implantation action of nylestriol and its effect on endometrium in rabbits].
The anti-implantation action of nylestriol in rabbits was studied. Using the method of arresting mitosis by injection of colchicine, we detected the mitosis frequency of endometrial cells. The activities of carbonic anhydrase (CAH), A1P and PAS reaction were observed under light microscope combined with the histochemical method and microscopic autoexposure control device. The results were as follows: 1. Giving nylestriol orally to rabbits on day 1 of pregnancy produced an obvious anti-implantation effect; 2. The number of mitosis cells in glandular epithelium and stroma of the endometrium in the treatment group was less than that in the control group (P < 0.05); and 3. Compared with the control group, the activities of CAH and A1P, and glycogen content in the endometrium decreased significantly in the treatment group (P < 0.05). The result suggests that nylestriol may prevent the implantation of blastocyst by disturbing decidulization of the endometrium.
Xie
W
W
Zheng
Q
Q
Lei
G
G
Han
Z
Z
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002256:Carbonic Anhydrases / Q000378:metabolism; D010064:Embryo Implantation / Q000187:drug effects*; D004717:Endometrium / Q000187:drug effects* / Q000201:enzymology; D045166:Estradiol Congeners / Q000494:pharmacology; D005260:Female; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D011897:Random Allocation
D045166:Estradiol Congeners; C010722:nylestriol; D000469:Alkaline Phosphatase; D002256:Carbonic Anhydrases; D011800:Quinestrol