title: Complex branch renovascular disease: management options and late results.
abstract: OBJECTIVE
  The purpose of this report is to review management options and late results of complex renovascular disease managed over the last 22 years.
  
  
  METHODS
  Complex branch renal artery disease in 84 kidneys was repaired during 75 operations performed in 68 consecutive patients. There were 61 females (90%) and 7 males (10%) whose predominant pathologic diagnosis was fibromuscular dysplasia manifesting as either renovascular hypertension or aneurysmal degeneration. These patients underwent 15 in situ, 52 ex vivo, and 8 combined reconstructions. In situ repair primarily with use of the bifurcated internal iliac artery autograft was used for primary lesions of the proximal renal artery bifurcation (two branches). Ex vivo repairs, primarily with use of the multibranch internal iliac autograft and hypothermic perfusion preservation, were used for all other patterns of distal renal artery branch disease and reoperative problems.
  
  
  RESULTS
  Renovascular reconstruction was successful in salvaging 83 of 84 kidneys (98.8%) in 67 of 68 patients. There were no operative deaths. Two reconstructions thrombosed in the early postoperative period. One was due to severe aortic disease, the other to branch artery dissection after a failed balloon angioplasty. Both patients continued to have hypertension. Before hospital discharge 65 patients had 81 renal revascularizations proven patent by arteriography. Their renal function was assessed and blood pressure was determined in a follow-up extending to 20 years (mean 7.5 years, median 7.9 years). Late arteriograms were obtained in 30 patients (46%) an average of 52 months after operation (range 6 months to 18 years). They demonstrate stable renal artery repair with no evidence of late graft failure in each. Hypertension was cured or improved in 51 of 53 patients (96%) with a proven patent reconstruction. Aneurysms were successfully repaired in 11 patients. Renal function was improved in four patients with ex vivo repairs, unchanged in 59 patients (15 in situ, 44 ex vivo), and persistently worse in only three patients, all of whom had in situ repairs.
  
  
  CONCLUSIONS
  The branched arterial autograft allows the restoration of normal renal arterial anatomy and function when inserted to replace complex distal renovascular disease. This provides a durable repair, essential for younger patients affected by this pattern of disease who anticipate a normal life span after renovascular repair. Successful long-term correction of diastolic hypertension and aneurysmal disease was accomplished without significant morbidity.
authors.affiliation: Division of Vascular Surgery, University of California, San Francisco 94143.
authors.forename: S P
authors.initials: SP
authors.lastname: Murray
authors.forename: C
authors.initials: C
authors.lastname: Kent
authors.forename: O
authors.initials: O
authors.lastname: Salvatierra
authors.forename: R J
authors.initials: RJ
authors.lastname: Stoney
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000783:Aneurysm / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis / Q000379:methods*; D002648:Child; D005260:Female; D005352:Fibromuscular Dysplasia / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D007036:Hypothermia, Induced; D007083:Iliac Artery / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012077:Renal Artery / Q000601:surgery*; D012079:Renal Circulation; D013997:Time Factors