title: The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.
abstract: A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.
authors.affiliation: Cancer Research Campaign, Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Teare
authors.forename: K
authors.initials: K
authors.lastname: Rohde
authors.forename: M F
authors.initials: MF
authors.lastname: Santibáñez Koref
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*