title: Sequence of the S fragment of foot-and-mouth disease virus type A12.
abstract: The foot-and-mouth disease virus (FMDV) genome contains a 5' untranslated region (S fragment) capable of forming a stem-loop structure of over 350 bases, which is separated from the remainder of the genome by a homopolymeric cytidylic acid tract (poly(C)) of variable length. The sequence of the S fragment of serotype A12 appears more similar to those of type O1 or type C3 than to subtype A10. The relatively large difference between the S fragment sequences of two type A viruses suggests that the sequences per se of this region of the genome are not critical for the maintenance of function, and suggests the possibility of a relatively recent recombination event within the poly(C) region of the A12 genome.
authors.affiliation: Plum Island Animal Disease Center, United States Department of Agriculture, Greenport, NY 11944.
authors.forename: T
authors.initials: T
authors.lastname: Bunch
authors.forename: E
authors.initials: E
authors.lastname: Rieder
authors.forename: P
authors.initials: P
authors.lastname: Mason
mesh_terms: D000595:Amino Acid Sequence; D005537:Aphthovirus / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011066:Poly C / Q000235:genetics; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
chemical_list: D018076:DNA, Complementary; D012367:RNA, Viral; D011066:Poly C