[Aspirin-induced asthma and arachidonic acid metabolites. In search of answers to an enigma. Part 2].
Acetylsalicylic acid is one of the most commonly used drugs and high on the list of causes of drug reactions. Since early publication on 1902 by Hirschberg, a great deal of information has emerged on aspirin sensitivity, including data on epidemiology, further characterization of the two major subtypes of sensitivity (bronchospastic and urticarial types), hereditary aspects, cross-reactions to other nonsteroidal antiinflammatory drugs, and methods of desensitization. Although the pathogenesis of aspirin-sensitive asthma remains unknown, several theories has been proposed to explain the disease enigma.
Salazar Villa
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RM
Div Allergy & Immunology, Scripps Clinic & Research Foundation, La Jolla, CA.
Zambrano Villa
S
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D016718:Arachidonic Acid / Q000378:metabolism*; D001241:Aspirin / Q000009:adverse effects* / Q000494:pharmacology; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D003888:Desensitization, Immunologic; D020022:Genetic Predisposition to Disease; D007249:Inflammation / Q000503:physiopathology; D008954:Models, Biological; D014777:Virus Diseases / Q000150:complications
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016718:Arachidonic Acid; D001241:Aspirin
Asma inducida por aspirina y metabolitos del ácido araquidónico. En búsqueda de respuestas a un enigma (segunda parte).