Repair of avulsed cervical nerve roots. An experimental study in sheep.
An experimental model was established to investigate the possibility of repairing cervical nerve roots avulsed from the spinal cord, as occurs in traction injuries of the brachial plexus. In five sheep the C6 root was avulsed and the ventral root was reattached using freeze-thawed muscle as a short graft (0.5 cm). Recovery was assessed after one year by electrophysiology and histology. Stimulation of the root produced muscle contractions in four out of five sheep. Action potentials were recorded distal to the grafts in all five sheep. Histological examination showed regenerated fibres in the ventral roots in all cases. These fibres could be traced distally to the brachial plexus. Our study confirms that motor fibres can regenerate out of the spinal cord into the ventral roots and reinnervate muscles, and suggests that reimplantation of avulsed roots is a surgical option in selected cases of traction injury of the brachial plexus.
Hems
T E
TE
University of Edinburgh Medical School, Scotland, UK.
Clutton
R E
RE
Glasby
M A
MA
D000200:Action Potentials; D000818:Animals; D001917:Brachial Plexus / Q000293:injuries / Q000503:physiopathology / Q000601:surgery*; D004558:Electric Stimulation; D004576:Electromyography; D008954:Models, Biological; D009119:Muscle Contraction; D009132:Muscles / Q000294:innervation / Q000503:physiopathology; D009333:Neck; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009416:Nerve Regeneration; D012092:Replantation; D012421:Rupture; D012756:Sheep; D013126:Spinal Nerve Roots / Q000293:injuries* / Q000503:physiopathology / Q000601:surgery*