beta-Amyloid protein-induced Alzheimer's disease animal model.
To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD.
Nitta
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A
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Itoh
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A
Hasegawa
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T
Nabeshima
T
T
D000544:Alzheimer Disease / Q000139:chemically induced* / Q000473:pathology / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000473:pathology; D002795:Choline O-Acetyltransferase / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology; D009474:Neurons / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
D016229:Amyloid beta-Peptides; D002795:Choline O-Acetyltransferase