Gangliosides modulate the development of ethyl-nitrosourea induced brain tumors in rats.
The possible effect of gangliosides as biological modifiers of the ethyl-nitrosourea (ENU) model of neurocarcinogenesis in rats is studied. Wistar rats that were exposed to ENU during fetal life, were treated with gangliosides at a postnatal age corresponding to a stage of pretumor or microtumor development. The results obtained suggest that postnatal administration of gangliosides can influence the development of ENU-induced brain tumors, delaying the appearance of symptomatic neoplasms and improving survival with respect to controls. This finding suggests the potential usefulness of gangliosides in the control of neuroectodermal tumors.
Vaquero
J
J
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Morales
C
C
Zurita
M
M
Oya
S
S
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002417:Cattle; D005038:Ethylnitrosourea; D005260:Female; D005732:Gangliosides / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D005732:Gangliosides; D007155:Immunologic Factors; D005038:Ethylnitrosourea