title: Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase.
abstract: We have isolated and characterized a new guanylyl cyclase gene (dgc1) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian soluble-type guanylyl cyclase alpha subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgc1 mRNA was detected in wild-type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgc1 is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgc1 may have a role in phototransduction.
authors.affiliation: Department of Molecular Neurobiology, University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: I
authors.initials: I
authors.lastname: Miyamoto
authors.forename: J
authors.initials: J
authors.lastname: Aruga
authors.forename: T
authors.initials: T
authors.lastname: Furuichi
authors.forename: H
authors.initials: H
authors.lastname: Okano
authors.forename: K
authors.initials: K
authors.lastname: Mikoshiba
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification; D004331:Drosophila melanogaster / Q000235:genetics*; D006162:Guanylate Cyclase / Q000737:chemistry / Q000235:genetics*; D006358:Hot Temperature; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
chemical_list: D012333:RNA, Messenger; D004247:DNA; D006162:Guanylate Cyclase