Deranged folic acid metabolism in diabetes-induced rats.
Metabolic changes in the folic acid and their conjugated polyglutamyl derivatives have been studied in streptozotocin-induced diabetic rats. Conjugated folates which constituted about 70% in normal rat liver get rapidly hydrolysed to simple unconjugated forms as the diabetes progressed leaving behind only 2% after 25 days of the onset of diabetes. Chromatographic analysis shows significant alterations in the formyl- and methyltetrahydrofolate derivatives and their polyglutamylation profiles. A 7-8 fold higher urinary excretion of mainly methyltetrahydrofolate is also observed in diabetic rats.
Pote
M S
MS
Radiation Biology & Biochemistry Division, Bhabha Atomic Research Centre, Bombay.
Kesavan
V
V
Noronha
J M
JM
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005492:Folic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005492:Folic Acid