[Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil].
METHODS
We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a "hibernating myocardium" during continuous infusion of 5-FU.


CONCLUSIONS
In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogenic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.
Unverdorben
M
M
Medizinische Klinik II mit Poliklinik, Universität Erlangen-Nürnberg.
Birkenhake
S
S
Kunkel
B
B
Dunst
J
J
D001005:Anus Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D012307:Risk Factors; D013997:Time Factors; D016277:Ventricular Function, Left
D005472:Fluorouracil
Ausgedehnte reversible globale linksventrikuläre Kontraktionsstörung als Folge einer zytostatischen Therapie mit 5-Fluorouracil bei unauffälligem Koronarsystem.