Elevated concentrations of circulating intercellular adhesion molecule 1 (ICAM-1) in HIV-1 infection.
The membrane-bound glycoprotein intercellular adhesion molecule 1 (ICAM-1) plays an important role for many cell-contact-dependent immune functions. A soluble, circulating form of ICAM-1 (cICAM-1) has been detected in the serum of healthy persons and increased concentrations in tumor patients have been reported. We measured serum levels of cICAM-1 in HIV-1-infected individuals with a recently developed ELISA. In contrast to HIV-seronegative controls (median value of 294 ng/ml, range of 185-408 ng/ml; n = 22), significantly elevated concentrations were detected in 76 HIV-1-infected persons (median of 487 ng/ml, range of 231-1,524 ng/ml; p < 0.0001). In HIV-1-infected individuals, cICAM-1 values did not correlate with the absolute number of CD4+ T cells or with disease progression according to the Walter Reed staging classification. Concentrations of cICAM-1 correlated with the serum concentrations of IL-6 (p = 0.0015; Spearman's rank correlation analysis) and with urinary neopterin (p = 0.005), but not with the C-reactive protein. Since there is evidence that cICAM-1 can interfere with immunological functions, the high amounts circulating in HIV-1-positive individuals could contribute to the disturbance of the immune system in HIV-1 infection.
Möst
J
J
Institut für Hygiene, Leopold-Franzens-Universität, Innsbruck, Austria.
Zangerle
R
R
Herold
M
M
Fuchs
D
D
Wachter
H
H
Fritsch
P
P
Dierich
M P
MP
D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000652:urine; D015497:HIV-1; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D015850:Interleukin-6 / Q000652:urine; D007958:Leukocyte Count; D008297:Male; D019798:Neopterin; D012016:Reference Values; D013601:T-Lymphocytes
D015815:Cell Adhesion Molecules; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1; D001708:Biopterins; D019798:Neopterin; D002097:C-Reactive Protein