title: Aggravation of ischemic neuronal damage in the rat hippocampus by impairment of histaminergic neurotransmission.
abstract: Delayed damage to hippocampal CA1 pyramidal cells was observed in rats subjected to cerebral ischemia caused by 10 min of 4-vessel occlusion. Animals pretreated with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, showed significantly more necrotic cells than did control animals. Mepyramine (H1-antagonist) and (R) alpha-methylhistamine (H3-agonist), but not zolantidine (H2-antagonist), significantly aggravated the delayed neuronal death. These results suggest that histaminergic neurons have a protective role, probably via H1-receptors, in the development of delayed neuronal death caused by cerebral ischemia.
authors.affiliation: Department of Pharmacology, Okayama University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Adachi
authors.forename: R
authors.initials: R
authors.lastname: Oishi
authors.forename: Y
authors.initials: Y
authors.lastname: Itano
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Hirakawa
authors.forename: K
authors.initials: K
authors.lastname: Saeki
mesh_terms: D000818:Animals; D052160:Benzothiazoles; D002545:Brain Ischemia / Q000139:chemically induced* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D006624:Hippocampus / Q000098:blood supply* / Q000166:cytology; D017442:Histamine Agonists / Q000633:toxicity; D006634:Histamine H1 Antagonists / Q000633:toxicity; D006635:Histamine H2 Antagonists / Q000633:toxicity; D008297:Male; D008761:Methylhistamines / Q000633:toxicity; D008762:Methylhistidines / Q000633:toxicity; D009474:Neurons / Q000187:drug effects*; D050198:Phenoxypropanolamines; D010880:Piperidines / Q000633:toxicity; D011738:Pyrilamine / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D011968:Receptors, Histamine / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013844:Thiazoles / Q000633:toxicity
chemical_list: D052160:Benzothiazoles; D017442:Histamine Agonists; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D008761:Methylhistamines; D008762:Methylhistidines; D050198:Phenoxypropanolamines; D010880:Piperidines; D011968:Receptors, Histamine; D013844:Thiazoles; C069357:alpha-methylhistamine; C028309:alpha-fluoromethylhistidine; D011738:Pyrilamine; C055302:zolantidine