title: Effects of territrem-B on cholinergic responses of snail neuron.
abstract: Effects of territrem-B (TRB), a mycotoxin isolated from a rice culture of Aspergillus terreus, on the central neuron of the snail Achatina fulica were studied electrophysiologically. Territrem-B potentiated the acetylcholine (ACh) induced current of the neuron, while it had no effect on GABA or L-glutamate elicited currents. TRB and neostigmine increased the peak amplitude of the response elicited by the first perfusion of ACh and depressed the increase in current produced by a second perfusion. TRB and neostigmine showed different dose-dependent effects on ACh responses. The results suggested that TRB is a good tool for studying the physiological role of AChE in central neurons.
authors.affiliation: Department of Pharmacology and Neurology, College of Medicine, National Taiwan University, Taipei, ROC.
authors.forename: V L
authors.initials: VL
authors.lastname: Arvanov
authors.forename: K H
authors.initials: KH
authors.lastname: Ling
authors.forename: R C
authors.initials: RC
authors.lastname: Chen
authors.forename: M C
authors.initials: MC
authors.lastname: Tsai
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D009388:Neostigmine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D011714:Pyrans / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D005971:Glutamates; D011714:Pyrans; D009388:Neostigmine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C040405:territrem B; D000109:Acetylcholine