H+/base transport pathways in the cortical collecting duct.
The CCD possesses the unique ability to alter not only the magnitude but also the direction of transepithelial H+/base and Cl- transport during changes in systemic acid-base balance. The single cell transport processes which are responsible for mediating these changes are presently incompletely understood. Functional evidence is emerging that the subdivision of intercalated cells into 2 subtypes is overly simplistic. The complexity of CCD H+/base transport is further demonstrated by the species differences which exist between the rat and rabbit. With the finding of a third CCD intercalated cell subtype (gamma cell), it is expected that future studies will focus on the transport changes which occur in this cell during systemic acid-base disorders.
Emmons
C
C
Kurtz
I
I
D000136:Acid-Base Equilibrium; D000818:Animals; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007679:Kidney Medulla / Q000166:cytology / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000166:cytology / Q000378:metabolism*; D008954:Models, Biological
D002712:Chlorides; D006859:Hydrogen