[Serum ACTH levels in patients treated for epilepsy].
In 27 epileptic patients (16 females and 11 males) aged 23-61 years, the serum ACTH levels were estimated by radioimmunoassay (RIA). The men serum ACTH level in epileptic patients was lower than in control group. In epileptic patients there were differences depending on the course of epilepsy and treatment applied. There were lower mean serum ACTH levels in patients with earlier age of epilepsy onset, frequent seizures and generalized discharges in eeg records. Lower serum ACTH amounts were found in patients with long-term treatment with phenytoin and polytherapy applied. It may be supposed that in patients long-term treated because of epilepsy the hormonal disturbances involve not only adrenal cortex but also higher parts of neuroendocrinological system.
Motta
E
E
Katedra i Klinika Neurologii Sl. AM, Zabrzu.
Rościszewska
D
D
Buntner
B
B
D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000276:immunology* / Q000378:metabolism; D000328:Adult; D017668:Age of Onset; D002220:Carbamazepine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000494:pharmacology / Q000627:therapeutic use; D011863:Radioimmunoassay
D002220:Carbamazepine; D010672:Phenytoin; D000324:Adrenocorticotropic Hormone
Poziom kortykotropiny (ACTH) w surowicy chorych leczonych z powodu padaczki.