title: Relationship between membrane protein phosphorylation and intracellular translocation of casein kinase in human erythrocytes.
abstract: The present paper shows that an increased phosphorylation of the membrane proteins, promoted by the okadaic acid (strong inhibitor of P-Ser/Thr-protein phosphatase(s)), is accompanied by a release of casein kinase from the membrane into cytosol. Such an intracellular translocation might provide a feedback mechanism for the regulation of the casein kinase catalyzed phosphorylation of membrane proteins in the human erythrocytes.
authors.affiliation: Dipartimento di Chimica Biologica, Università di Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bordin
authors.forename: G
authors.initials: G
authors.lastname: Clari
authors.forename: B
authors.initials: B
authors.lastname: Baggio
authors.forename: G
authors.initials: G
authors.lastname: Gambaro
authors.forename: V
authors.initials: V
authors.lastname: Moret
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D047388:Casein Kinases; D003600:Cytosol / Q000201:enzymology; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008565:Membrane Proteins / Q000097:blood* / Q000302:isolation & purification; D010750:Phosphoproteins / Q000097:blood* / Q000302:isolation & purification; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D011494:Protein Kinases / Q000097:blood*
chemical_list: D008565:Membrane Proteins; D010750:Phosphoproteins; D010761:Phosphorus Radioisotopes; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D047388:Casein Kinases