The influence of ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of temazepam in the young and elderly.
The effect of pretreatment with a 4-day course of ciprofloxacin (500 mg twice daily) on the pharmacokinetics and pharmacodynamics of a single oral dose of temazepam (10 mg) was investigated in 12 healthy young and nine elderly patient volunteers in a crossover design study. Temazepam clearance was lower in the elderly than in the young, but this difference was not statistically significant. Ciprofloxacin had no significant effect on temazepam pharmacokinetics or pharmacodynamics in either age group.
Kamali
F
F
Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, U.K.
Herd
B
B
Edwards
C
C
Nicholson
E
E
Wynne
H
H
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013693:Temazepam / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology
D002939:Ciprofloxacin; D013693:Temazepam