The role of cell-mediated immunity in candidiasis.
Clinical observations and animal models show that cell-mediated immunity (CMI) is an important host defense mechanism against Candida albicans infections. In HIV-infected patients, a switch from TH1- to TH2-type CMI responses correlates with the progression to AIDS, and may also increase susceptibility to mucosal candidiasis.
Fidel
P L
PL
Divn of Infectious Diseases, Wayne State University School of Medicine, Harper Hospital, Detroit, MI 48201.
Sobel
J D
JD
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000818:Animals; D002177:Candidiasis / Q000276:immunology*; D002181:Candidiasis, Vulvovaginal / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005759:Gastroenteritis / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D051379:Mice; D016513:Mice, SCID