Primary central nervous system involvement of the so called 'peripheral T-cell lymphoma'. Report of a case and review of the literature.
Primary central nervous system (CNS) involvement of non-Hodgkin's lymphoma is uncommon and a vast majority of reported cases are of B-cell origin. We present a 52-year-old woman with primary peripheral T-cell lymphoma of the brain. Immunostaining of paraffin-embedded sections proved tumor cells to be positive for T-cell markers MT1 and UCHL1, and negative for B-cell markers MB1, and 4KB5. Radiotherapy combined with steroid therapy rendered neurologic recovery and complete tumor remission confirmed by computed tomography and magnetic resonance imaging. From a review of documented 19 cases of primary CNS T-cell lymphoma including the present case, this disease is characterized by poor prognosis among CNS lymphomas.
Mineura
K
K
Neurosurgical Service, Akita University Hospital, Japan.
Sawataishi
J
J
Sasajima
T
T
Kowada
M
M
Sugawara
A
A
Ebina
K
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001254:Astrocytoma / Q000175:diagnosis; D001479:Basal Ganglia; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015993:Life Tables; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D016399:Lymphoma, T-Cell / Q000145:classification* / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy; D008727:Methotrexate / Q000008:administration & dosage; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D016019:Survival Analysis; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003907:Dexamethasone; D008775:Methylprednisolone; D008727:Methotrexate