title: Hemophilia A presenting with intracranial hemorrhage in neonate: a case report.
abstract: Intracranial hemorrhage (ICH) in a neonate is an uncommon presentation of hemophilia. Its occurrence is invariably preceded by mild-to-moderate head injury, unlike adult hemophiliacs in whom ICH occurs without prior head injury in half the cases. The bleeding event may follow a minor injury of labor (eg, prolonged second stage of labor or the use of forceps). In a recent experience at our hospital, a 6 D/O male baby with hemophilia A presenting with ICH after traumatic delivery was later found to have factor VIII deficiency. We suggest that prenatal management for suspected cases should take family history of bleeding disorders and carrier testing into consideration. Any term neonate with ICH should eliminate the possibility of hemophilia until proved otherwise. Some specific diagnostic and therapeutic recommendations to assist the clinician to evaluate an infant with ICH and prolonged PTT are discussed.
authors.affiliation: Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.forename: W J
authors.initials: WJ
authors.lastname: Soong
authors.forename: Y L
authors.initials: YL
authors.lastname: Hsieh
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Hwang
mesh_terms: D002543:Cerebral Hemorrhage / Q000209:etiology*; D006467:Hemophilia A / Q000150:complications* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male