Lymphatic fatty acids from rats fed human milk and formula containing coconut oil.
Human milk and infant formula containing coconut/soy oil were infused into the duodenum of rats to determine the incorporation of capric, lauric, myristic and palmitic acids into lymphatic triacylglycerol (TAG). The proportion of capric and lauric acids in the lymphatic TAG reflected the fatty acid composition of the diet. Based on positional analysis, it appears that more than 50% of the capric and lauric acids could have been absorbed from the intestine as sn-2 monoacylglycerols. In the rats fed human milk, 50% of palmitic acid in lymphatic TAG was in the sn-2 position. Because of the nonrandom distribution of palmitic acid in the lymphatic TAG, the nonspecific lipase in human milk, i.e., bile salt-stimulated lipase, did not appear to be a factor in milk lipid digestion.
Roche
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Department of Nutritional Sciences, University of Connecticut, Storrs 06269-4017.
Clark
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RM
D000818:Animals; D000074263:Coconut Oil; D003066:Coenzyme A Ligases / Q000378:metabolism; D004063:Digestion; D004386:Duodenum / Q000378:metabolism; D004951:Esterification; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007225:Infant Food; D007408:Intestinal Absorption; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D008895:Milk, Human / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000378:metabolism; D010938:Plant Oils / Q000378:metabolism*; D051381:Rats; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014280:Triglycerides / Q000378:metabolism; D000098859:Long-Chain-Fatty-Acid-CoA Ligase
D005227:Fatty Acids; D010712:Phosphatidic Acids; D010938:Plant Oils; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014280:Triglycerides; D003066:Coenzyme A Ligases; C090799:FAA2 protein, S cerevisiae; D000098859:Long-Chain-Fatty-Acid-CoA Ligase; D000074263:Coconut Oil