Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.
We have determined the chromosomal location of the human genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S alpha 3 and beta 3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3-4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.
Giuili
G
G
Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor, Créteil, France.
Roechel
N
N
Scholl
U
U
Mattei
M G
MG
Guellaen
G
G
D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006162:Guanylate Cyclase / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D012995:Solubility
D006162:Guanylate Cyclase