Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology.
The Rpt-1 gene product is an intranuclear protein expressed by CD4+ T-cells, which may regulate expression of the interleukin-2 receptor. Structural analysis of Rpt-1 reveals structural motifs that are shared by a group of transcriptional regulatory proteins with oncogenic potential. We suggest that altered expression of Rpt-1 may be associated with HTLV-I-dependent T-cell leukemias.
Patarca
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E.M. Papper Laboratory of Clinical Immunology, University of Miami School of Medicine, FL 33101.
Fletcher
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MA
Cantor
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D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000235:genetics; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D006801:Humans; D016350:Leucine Zippers / Q000235:genetics; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D016335:Zinc Fingers / Q000235:genetics; D000099207:SS-A Antigen
D001324:Autoantigens; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human