The hyperperfusion of the psoriatic plaque correlates histologically with dilatation of vessels.
We examined psoriatic lesions on the upper legs in 20 patients, using a two-dimensional Laser-Doppler-Scanner (Laser Doppler Perfusion Imager LDI, Lisca Development, Linköping/Sweden). The plaques were evaluated weekly during therapy with dithranol. Five plaques were reconstructed three-dimensionally before and after therapy (reconstruction program ANAT 3D, SIS, Münster, Germany). The psoriatic plaque was represented in the Laser Doppler Perfusion image as a sharply demarcated, hyperperfused area. The perfusion of the plaques dropped during therapy with dithranol to just slightly increased values, compared with normal skin (2.04 arbitrary units AU, healthy skin 1.1 AU). Using three-dimensional reconstruction, we investigated the volume of dermal vessels and the density of papillae. When compared, the volume of papillary vessels was twice as large in psoriatic as in healthy skin. The number of the papillae per square millimetre, detected by three-dimensional reconstruction, was not reduced significantly during therapy. We think that the increased perfusion of the psoriatic plaque is due to the combination of morphological (dilatation of vessels), dynamic (increased blood flow) and optical effects (reduced scattering and increased sampling depth of the laser-beam in acanthotic tissue).
Auer
T
T
Dermatological Clinic, Ruhr University, Bochum, Germany.
Bacharach-Buhles
M
M
el-Gammal
S
S
Stücker
M
M
Panz
B
B
Popp
C
C
Hoffmann
K
K
Happe
M
M
Altmeyer
P
P
D000875:Anthralin / Q000627:therapeutic use; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017078:Laser-Doppler Flowmetry; D011565:Psoriasis / Q000188:drug therapy / Q000503:physiopathology*; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*
D000875:Anthralin