title: Evaluation of a new chelating agent for cadmium: a preliminary report.
abstract: The Plasma Mobilizing Index parameters of the newly synthesized chelating agent THP-12-ane N4, determined by computer simulation studies, have indicated that this chelating agent might be a good antagonist for cadmium intoxication. Experiments conducted on rats confirmed this observation and showed that THP-12-ane N4 might have the ability to chelate and mobilize cadmium in vivo.
authors.affiliation: Department of Biochemistry, Department of National Health and Population Development, Johannesburg, Republic of South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Gulumian
authors.forename: E
authors.initials: E
authors.lastname: Casimiro
authors.forename: P W
authors.initials: PW
authors.lastname: Linder
authors.forename: D B
authors.initials: DB
authors.lastname: Rama
authors.forename: R D
authors.initials: RD
authors.lastname: Hancock
mesh_terms: D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000097:blood* / Q000652:urine; D002614:Chelating Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D003198:Computer Simulation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D007928:Lethal Dose 50; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D011916:Rats, Inbred F344; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D002614:Chelating Agents; D006571:Heterocyclic Compounds; D002104:Cadmium; C082033:N,N',N'',N'''-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane