Effects of repeated dopamine D1 receptor stimulation on rotation and c-fos expression.
Acute injections of the full dopamine D1 receptor agonist A-77636 ((1R,3S)-3-(1'adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1 H-2-benzopyran hydrochloride) induce ipsilateral Fos-like immunoreactivity and contralateral rotation into rats bearing unilateral dopamine depleting lesions. However, following repeated treatment, A-77636 fails to induce either striatal c-fos or rotation. Our results suggest that striatal c-fos activation mirrors behavioral indices of dopamine D1 receptor sensitivity.
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Neuroscience Research Division, Abbott Laboratories, Abbott Park, IL 60064.
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D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology*; D004361:Drug Tolerance; D005786:Gene Expression Regulation / Q000187:drug effects; D016762:Genes, fos; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000378:metabolism
D001578:Benzopyrans; D015259:Dopamine Agents; D016760:Proto-Oncogene Proteins c-fos; D017447:Receptors, Dopamine D1; C079415:A 77636; D000218:Adamantane