title: Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.
abstract: Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.
authors.affiliation: Department of Psychiatry and Human Behavior, Jefferson Cancer Institute, Philadelphia, Pennsylvania.
authors.forename: W H
authors.initials: WH
authors.lastname: Berrettini
authors.forename: T N
authors.initials: TN
authors.lastname: Ferraro
authors.forename: R C
authors.initials: RC
authors.lastname: Alexander
authors.forename: A M
authors.initials: AM
authors.lastname: Buchberg
authors.forename: W H
authors.initials: WH
authors.lastname: Vogel
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004276:DNA, Satellite; D004327:Drinking Behavior; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics* / Q000502:physiology; D008811:Mice, Inbred DBA / Q000235:genetics* / Q000502:physiology; D009021:Morphine Dependence / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction
chemical_list: D004276:DNA, Satellite