title: Direct immunofluorescent studies of skin biopsies in pemphigus.
abstract: Direct immunofluorescent studies of skin biopsies from 16 pemphigus vulgaris patients revealed immunoglobulin deposits in 12 (75%) cases with fluorescence at intercellular areas in epidermis. In 2 patients (12.5%) dermoepidermal junction also showed immunoglobulin deposits. IgG was the commonest type of immunoglobulin demonstrated in 12 out of 16 (75%) cases followed by IgM in 5 (31.25%) and IgA in 1 (6.25%) cases. Seven (43.75%) cases showed presence of IgG alone while IgM with IgG was found in 4 (25%) cases. One (6.25%) case showed deposition of IgG, IgM and IgA. The results indicated that demonstration of immunoglobulin in skin biopsies by direct immunofluorescent technique is quite a useful adjunct in diagnostic confirmation of pemphigus.
authors.affiliation: Department of Pathology, S.P. Medical College, Bikaner.
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: H L
authors.initials: HL
authors.lastname: Arora
authors.forename: P M
authors.initials: PM
authors.lastname: Sareen
authors.forename: H S
authors.initials: HS
authors.lastname: Kumar
mesh_terms: D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D008297:Male; D010392:Pemphigus / Q000276:immunology*; D012867:Skin / Q000276:immunology*
chemical_list: D007132:Immunoglobulin Isotypes