title: Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia.
abstract: The cytokine macrophage migration inhibitory factor (MIF) is a major protein constituent of the anterior pituitary gland released into the bloodstream during endotoxaemia. For many years, MIF had been thought to be a T cell product associated with delayed-type hypersensitivity reactions. The identification of MIF as a pituitary 'stress' hormone provides an important link in the regulation of systemic inflammatory responses by the central nervous system.
authors.affiliation: Picower Institute for Medical Research, Manhasset, NY 11030.
authors.forename: J
authors.initials: J
authors.lastname: Bernhagen
authors.forename: T
authors.initials: T
authors.lastname: Calandra
authors.forename: A
authors.initials: A
authors.lastname: Cerami
authors.forename: R
authors.initials: R
authors.lastname: Bucala
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000097:blood / Q000378:metabolism*; D004731:Endotoxins / Q000097:blood*; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D010902:Pituitary Gland / Q000378:metabolism*
chemical_list: D004731:Endotoxins; D008263:Macrophage Migration-Inhibitory Factors