title: Proliferating cell nuclear antigen (PCNA) in medullary thyroid carcinoma.
abstract: We investigated the expression of proliferating cell nuclear antigen (PCNA) in paraffin sections from 20 cases of medullary thyroid carcinoma (MTC). Follow-up data were available in eleven cases. PCNA index positively correlated with the degree of cellular pleomorphism (grade) of the tumor (p < 0.01), the pathologic stage (p < 0.01) and the poor clinical outcome (p < 0.05). These findings suggest that PCNA may be of prognostic significance in MTC.
authors.affiliation: Pathology Department, Asklepeion Hospital, Voula Attikis, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Skopelitou
authors.forename: P
authors.initials: P
authors.lastname: Korkolopoulou
authors.forename: A
authors.initials: A
authors.lastname: Papanikolaou
authors.forename: M
authors.initials: M
authors.lastname: Hadjiyannakis
mesh_terms: D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D002277:Carcinoma / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen; D013964:Thyroid Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen