title: Characterization of the amyloid fibril from primary localized cutaneous nodular amyloidosis associated with Sjögren's syndrome.
abstract: BACKGROUND
  Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown.
  
  
  OBJECTIVE
  The purpose of this study was to know the origin of amyloid in PLCNA.
  
  
  METHODS
  Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis.
  
  
  RESULTS
  The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies.
  
  
  CONCLUSIONS
  Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones.
authors.affiliation: Department of Dermatology, Urawa Municipal Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inazumi
authors.forename: M
authors.initials: M
authors.lastname: Hakuno
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: W
authors.initials: W
authors.lastname: Naka
authors.forename: S
authors.initials: S
authors.lastname: Tajima
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
chemical_list: D000682:Amyloid; C035222:amyloid protein AL