[A study of CGRP receptor and its effect on the growth of human pancreatic carcinoma cells].
In the present studies the calcitonin gene-related peptide (CGRP) receptors were characterized by radioligand analysis and the effect of CGRP and CGRP receptor antagonist on the growth of human pancreatic carcinoma cells (PU-PAN-1) was determined by 3H-TdR incorporation assay. The results indicated that human pancreatic carcinoma cells possess distinct CGRP receptors. CGRP stimulated the growth of PU-PAN-1 tumor cells, and CGRP receptor antagonist CGRP8-37 inhibited these effects. These results suggests that CGRP receptors may play an important role in the growth of human pancreatic carcinoma cells (PU-PAN-1).
Zhou
Z
Z
PUMC Hospital, CAMS and PUMC, Beijing.
D001667:Binding, Competitive; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*; D010446:Peptide Fragments / Q000494:pharmacology*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000737:chemistry / Q000187:drug effects
D010446:Peptide Fragments; D018015:Receptors, Calcitonin Gene-Related Peptide; C058636:calcitonin gene-related peptide (8-37); D015740:Calcitonin Gene-Related Peptide