title: Molecular mimicry in Lyme disease: monoclonal antibody H9724 to B. burgdorferi flagellin specifically detects chaperonin-HSP60.
abstract: A monoclonal antibody (H9724), specific for the 41-kDa flagellar protein of the Lyme disease pathogen Borrelia burgdorferi, cross-reacts with human axons and detects one major protein in human neuroblastoma cell extracts. The homologous cross-reacting protein has now been isolated from calf adrenal and identified as chaperonin-HSP60 by N-terminal sequencing.
authors.affiliation: Center for Advanced Biotechnology and Medicine, Piscataway, NJ.
authors.forename: Z
authors.initials: Z
authors.lastname: Dai
authors.forename: H
authors.initials: H
authors.lastname: Lackland
authors.forename: S
authors.initials: S
authors.lastname: Stein
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Radziewicz
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: L H
authors.initials: LH
authors.lastname: Sigal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001369:Axons / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002417:Cattle; D018834:Chaperonin 60; D018833:Chaperonins; D003429:Cross Reactions; D005408:Flagellin / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis / Q000276:immunology*; D008969:Molecular Sequence Data; D011506:Proteins / Q000276:immunology*; D016415:Sequence Alignment; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D001426:Bacterial Proteins; D018834:Chaperonin 60; D006360:Heat-Shock Proteins; D011506:Proteins; D005408:Flagellin; D018833:Chaperonins