Hyperammonemia induced in rats by inhalation anesthesia with ether.
Transient hyperammonemia was observed in rats after inhalation anesthesia with ether. The elevation of blood ammonia concentration induced by ether anesthesia was greatest in carbon tetrachloride injured and indomethacin-treated rats, but not observed in phenobarbital-treated rats. The results suggest interaction between ether metabolism and ammonia metabolism in the liver.
Watanabe
A
A
Third Department of Internal Medicine, Faculty of Medicine, Toyama, Japan.
Kuwabara
Y
Y
D000641:Ammonia / Q000097:blood* / Q000378:metabolism; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004986:Ether / Q000633:toxicity*; D007213:Indomethacin / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D004986:Ether; D000641:Ammonia; D002251:Carbon Tetrachloride; D007213:Indomethacin; D010634:Phenobarbital