[Effect of three antihypertensive drug groups on lipid metabolism. Effects of alpha receptor blockers, central sympatholytic drugs and vasodilators].
Basic remarks and aims: Alpha-receptor blockers, central sympathicolytic agents and vasodilators are all drugs that are often used to treat hypertension. On the basis of a study of the literature, the effects of these groups of substances on lipid metabolism are described. Main points discussed: Although the data available are few, vasodilators, in particular dihydralazine and hydralazine appear to have no unfavorable effect on serum lipids. Nor do the centrally acting alpha-receptor agonists, such as methyldopa and clonidine have any unfavorable effect, with the exception of the decrease in the HDL cholesterol observed under methyldopa. The selective alpha-1-receptor blockers, prazosin, doxazosin and urapidil, even have a positive effect of varying degree on lipid metabolism: increase in HDL cholesterol and decrease in triglycerides. Long-term studies over a number of years are, however, lacking. The effect of labetalol, reserpine and guanethidine on lipid metabolism cannot yet be definitively assessed owing to a lack of data.
Jacob
B G
BG
Richter
W O
WO
Schwandt
P
P
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D013565:Sympatholytics / Q000009:adverse effects* / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D008055:Lipids; D013565:Sympatholytics; D014665:Vasodilator Agents
Einfluss dreier antihypertensiver Wirkgruppen auf den Fettstoffwechsel. Effekte von Alpharezeptorenblockern, zentralen Sympatholytika und Vasodilatatoren.