[Genetics and cancer of the breast].
Breast carcinoma is the commonest cancer in women. Segregation analyses support the existence of a major susceptibility gene with a dominant pattern of inheritance in 4 to 10% of cases. Three genes involved in the genetic predisposition to breast tumors have recently been identified: BRCA-1 associated with early onset familial breast cancer and breast/ovarian carcinoma syndrome, p53 associated with Li-Fraumeni syndrome, and the androgen receptor gene in male breast cancer with Reinfenstein syndrome. A better understanding of inherited contribution may have important implications for screening individuals at high-risk in families.
Sobol
H
H
Bignon
Y J
YJ
Eisinger
F
F
Birnbaum
D
D
Fervers
B
B
D001260:Ataxia Telangiectasia / Q000235:genetics; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics*; D008297:Male; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics*
Génétique et cancer du sein.