title: Insulin independence in type I diabetes after transplantation of unpurified islets from single donor with 15-deoxyspergualin.
abstract: Islet transplantation has been slow to develop as a therapy for type I diabetes mellitus. Conventional immunosuppression does not protect islet allografts from early failure and by current techniques the yield of purified islets from a single pancreas is inadequate or only marginally in excess of the number needed to sustain normoglycaemia. We transplanted unpurified islets from a single pancreas concomitantly with a kidney to two uraemic diabetic patients. The novel agent 15-deoxyspergualin, along with antilymphocyte globulin, was used for induction immunosuppression, and azathioprine, prednisone, and cyclosporin for maintenance. Islet function has been sustained in both, and the second patient is insulin-independent and euglycaemic more than 6 months after transplantation.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis.
authors.forename: P F
authors.initials: PF
authors.lastname: Gores
authors.forename: J S
authors.initials: JS
authors.lastname: Najarian
authors.forename: E
authors.initials: E
authors.lastname: Stephanian
authors.forename: J J
authors.initials: JJ
authors.lastname: Lloveras
authors.forename: S L
authors.initials: SL
authors.lastname: Kelley
authors.forename: D E
authors.initials: DE
authors.lastname: Sutherland
mesh_terms: D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage*; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014019:Tissue Donors
chemical_list: D000961:Antilymphocyte Serum; D006146:Guanidines; D007166:Immunosuppressive Agents; D007328:Insulin; D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; C037258:gusperimus; D011241:Prednisone