High performance liquid chromatographic analysis of quinolone antibacterial agents.
Eleven quinolone antibacterials have been analyzed by HPLC. The effects of different pH values and organic modifiers on chromatographic behaviour are discussed. Moreover the influence on separation mechanism of different counter-ions at various concentrations in the eluent has been investigated. Two different chromatographic methods have been selected, that allow the simultaneous analysis of quinolones containing or not a piperazinyl moiety, respectively.
Barbato
F
F
Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Napoli Federico II, Italy.
Morrica
P
P
Seccia
S
S
Ventriglia
M
M
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006863:Hydrogen-Ion Concentration; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents