Interrelationships of the concentrations of some ionic constituents of human milk and comparison with cow and goat milks.
1. Milk and milk ultrafiltrate samples from four women (Homo sapiens) during the first 16 weeks of lactation were analysed for the main salt constituents, protein and lactose and the interrelationships of these constituents were determined. 2. A good positive correlation was observed between ultrafiltrate calcium and citrate concentrations, as previously observed for cow (Bos taurus) and goat (Capra hircus) milk but the expected negative correlation of lactose with ultrafiltrate salts was poor. 3. An invariant ion activity product for milk calcium phosphate was found for a dicalcium phosphate stoichiometry but the milk serum was less supersaturated with respect to calcium phosphate and citrate salts than ruminant milks. 4. The observed interrelationships are discussed in relation to the constraints on human milk composition arising from a fixed osmotic pressure, overall charge neutrality and saturation with respect to calcium phosphate.
Holt
C
C
Hannah Research Institute, U.K.
D000818:Animals; D002118:Calcium / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D002417:Cattle; D003102:Colloids / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006041:Goats; D006801:Humans; D007774:Lactation / Q000502:physiology; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D009994:Osmolar Concentration; D011188:Potassium / Q000737:chemistry; D012995:Solubility; D014462:Ultrafiltration
D002130:Calcium Phosphates; D003102:Colloids; D004573:Electrolytes; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D011188:Potassium; D002118:Calcium