Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.
Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced only slightly. By contrast, the mRNA levels of interleukin 1 beta, colony-stimulating factor 1 receptor, and tumor necrosis factor alpha increased following infection.
Kyuwa
S
S
Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033.
Cohen
M
M
Nelson
G
G
Tahara
S M
SM
Stohlman
S A
SA
D000199:Actins / Q000096:biosynthesis; D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D017934:Coronavirus / Q000472:pathogenicity* / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D007375:Interleukin-1 / Q000096:biosynthesis; D007700:Kinetics; D007739:L Cells; D051379:Mice; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000302:isolation & purification; D012367:RNA, Viral / Q000096:biosynthesis* / Q000302:isolation & purification; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000199:Actins; D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I; D007375:Interleukin-1; D012333:RNA, Messenger; D012367:RNA, Viral; D014409:Tumor Necrosis Factor-alpha; D016186:Receptor, Macrophage Colony-Stimulating Factor