Astrocytoma with a unique telomere association.
Many primary pediatric brain tumors are characterized by nonrandom cytogenetic abnormalities involving specific structural rearrangements and loss or gain of specific chromosomes. We describe a low-grade cerebellar astrocytoma with telomeric association of chromosomes 18 and 21 in a 7-year old girl. The nonrandom telomeric association of these chromosomes represents a unique cytogenetic finding in this type of pediatric brain tumor.
Harrison
K J
KJ
Cytogenetics/Embryopathology Laboratory, British Columbia Children's Hospital, Vancouver.
Neumann
E
E
Kalousek
D K
DK
Norman
M G
MG
Masui
S
S
Harrison
K
K
D001254:Astrocytoma / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D016615:Telomere