Two components of repair in irradiated kidney colony forming cells.
Data describing the response of mouse kidney colony-forming cells to fractionated X-irradiation using different interfraction intervals were analysed in order to detect the presence of one or more components of repair. A two-component repair model gave a superior fit, with reference to a single-repair rate model, giving distinct repair halftimes of 0.15 (approximate 95% confidence limits: 0.0, 0.40) and 5.03 (1.23, 8.84) h. These values are the first reported for normal cells in vivo, and they are similar to values calculated for tissue responses in skin, lung and the spinal cord. The slow component of repair is important in radiotherapy, in particular regarding novel hyperfractionation regimens when interfraction intervals much less than 1 day are employed.
Millar
W T
WT
Department of Radiation Oncology, Beatson Laboratories, University of Glasgow, UK.
Jen
Y M
YM
Hendry
J H
JH
Canney
P A
PA
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D007668:Kidney / Q000166:cytology / Q000502:physiology* / Q000528:radiation effects*; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology; D008432:Mathematical Computing; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology* / Q000528:radiation effects*