title: The anticoagulant action of phospholipase A from Eresus niger spider venom.
abstract: Phospholipase A, named component EnPA, was isolated from Eresus niger spider venom. It was determined to be a single peptide chain with mol. wt of 13,000. Component EnPA showed high anticoagulant activity when the APTT was measured in spite of its low enzymatic activity (30 +/- 6 mumol/min/mg). It was concluded that anticoagulant action of compound EnPA is due to inactivation of the procoagulant activity of phospholipids because of its high binding with them.
authors.affiliation: Institute of Physiology and Biophysics, Uzbek Academy of Sciences, Tashkent.
authors.forename: P B
authors.initials: PB
authors.lastname: Usmanov
authors.forename: F A
authors.initials: FA
authors.lastname: Nuritova
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D006801:Humans; D010741:Phospholipases A / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013045:Species Specificity; D013111:Spider Venoms / Q000737:chemistry*
chemical_list: D013111:Spider Venoms; D010741:Phospholipases A