Variables affecting nicotine metabolism.
Nicotine metabolism is exceedingly sensitive to perturbation by numerous host factors. To reduce the large variations and discrepancies in the literature pertaining to nicotine metabolism, investigators in future studies need to recognize and better control these host factors. Recent advances in the understanding of nicotine metabolism have suggested new approaches to elucidating underlying mechanisms of certain toxic effects associated with cigarette smoking.
Seaton
M J
MJ
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033.
Vesell
E S
ES
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D009538:Nicotine / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D011247:Pregnancy / Q000378:metabolism; D012907:Smoking; D013045:Species Specificity
D004044:Dietary Proteins; D000431:Ethanol; D009538:Nicotine; D002927:Cimetidine