Gastric bicarbonate secretion in high-relapsing, smoking duodenal ulcer patients.
Gastric bicarbonate secretion has been evaluated by Feldman's method in 48 duodenal-ulcer patients. The relationship between smoking, clinical ulcer outcome (healing and recurrence) and bicarbonate secretion has been analysed. Heavy smokers secreted higher bicarbonate ions than did non-smokers. High-relapsing patients produced lower bicarbonate output. These preliminary data suggest that an impaired gastric bicarbonate secretion is associated with smoking, a well-known ulcer-associated factor; further-more, it may single out high-relapsing duodenal ulcer patients.
Dal Santo
P
P
Istituto di Medicina Interna, Università degli Studi di Padova, Italy.
Vianello
F
F
Germana
B
B
Del Bianco
T
T
Laino
G
G
Grassi
S A
SA
Plebani
M
M
Dotto
P
P
Battaglia
G
G
Di Mario
F
F
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology / Q000503:physiopathology*
D001639:Bicarbonates; D006635:Histamine H2 Antagonists