Inhibitory action of benidipine on balloon catheterization-induced intimal thickening of the carotid artery in rats.
We examined the effect of benidipine, a long lasting Ca2+ channel blocker, on balloon catheterization-induced intimal thickening of the carotid artery in rats. In the carotid arteries of vehicle-treated rats, neo-intima formation and elevation of DNA content was observed at 14 days after the surgery. Benidipine (5 mg/kg, p.o., b.i.d.) halved the intimal thickening and suppressed the elevated DNA-content in the balloon catheter-injured artery. These results suggest that benidipine may be useful for the treatment of vascular proliferative diseases like restenosis following percutaneous transluminal angioplasty.
Ide
S
S
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Kondoh
M
M
Satoh
H
H
Karasawa
A
A
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002339:Carotid Arteries / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure*; D002404:Catheterization; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004095:Dihydropyridines / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology; D006651:Histocytochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C061004:benidipine; D004247:DNA