title: Acute autoimmune response in a case of pyromellitic acid dianhydride-induced hemorrhagic alveolitis.
abstract: A 17-year-old man was occupationally exposed to pyromellitic acid dianhydride dust during the production of epoxy resin in a chemical factory. He was clinically diagnosed as having acute hemorrhagic alveolitis associated with anemia. The serologic analysis revealed a high concentration of IgG antibodies against pyromellitic acid dianhydride-treated human serum albumin (PMDA-HSA). Immunoblotting with PMDA-treated human serum as antigen and the patient's serum as the first antibody showed that additional PMDA-modified serum proteins other than HSA were recognized by the patient's IgG antibodies in the higher mol. mass range (> 67 kDa). No specific IgG could be detected against other anhydride conjugates (maleic acid, MA; phthalic acid, PA) with the exception of a reaction with the trimellitic acid anhydride-conjugated HSA (TMA-HSA). No specific IgE antibodies could be detected against any of the above mentioned antigens, but immunoblotting of the patient's serum indicated IgG4-type autoantibodies against in vitro PMDA-treated Ig molecules of normal serum proteins.
authors.affiliation: Department of Allergology, Ruhr-University of Bochum, Germany.
authors.forename: A B
authors.initials: AB
authors.lastname: Czuppon
authors.forename: V
authors.initials: V
authors.lastname: Kaplan
authors.forename: R
authors.initials: R
authors.lastname: Speich
authors.forename: X
authors.initials: X
authors.lastname: Baur
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D000542:Alveolitis, Extrinsic Allergic / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D001565:Benzoates / Q000009:adverse effects* / Q000276:immunology; D001798:Blood Proteins / Q000276:immunology; D002617:Chemical Industry; D003429:Cross Reactions; D004391:Dust / Q000009:adverse effects*; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008970:Molecular Weight; D016273:Occupational Exposure; D010796:Phthalic Anhydrides / Q000009:adverse effects / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology
chemical_list: D000485:Allergens; D001565:Benzoates; D001798:Blood Proteins; D004391:Dust; D007074:Immunoglobulin G; D010796:Phthalic Anhydrides; D012709:Serum Albumin; C012019:pyromellitic dianhydride; D007073:Immunoglobulin E; C015559:trimellitic anhydride