Clearance of infused triglyceride by resting horses.
1. Clearance of infused lipid was observed in six mature resting horses, 2 to 6 hr after receiving a meal of alfalfa hay. 2. Intralipid, a 10% triglyceride emulsion, was infused at a rate of 0.2 ml/kg into the jugular vein. 3. Blood samples were obtained for 80 min post-infusion and assayed for plasma triglyceride concentration. 4. Clearance rate of the infused lipid was very slow (mean t1/2 = 269 min). 5. The clearance rate of the infused lipid in these horses was much slower than has been observed in other species. 6. The slow clearance of infused triglyceride in horses may suggest an inability to efficiently metabolize lipoproteins.
Moser
L R
LR
Department of Animal Sciences, University of Illinois, Urbana 61801.
Lawrence
L M
LM
Novakofski
J
J
Powell
D M
DM
D000818:Animals; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics; D005260:Female; D006207:Half-Life; D006736:Horses / Q000097:blood*; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D012146:Rest / Q000502:physiology; D014280:Triglycerides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides