Biochemical parameters of recovery in acute severe head injury.
Levels of urinary catecholamines (noradrenaline, adrenaline, dopamine), plasma acetylcholinesterase, serum serotonin and plasma 3-methoxy-4-hydroxyphenylglycol were recorded in 38 adult subjects during the first 21 days after severe head injury. Levels of acetylcholinesterase, serotonin and 3-methoxy-4-hydroxyphenylglycol differed significantly between survivors and those who died. For survivors, initially abnormal biochemical levels recovered toward the norm as time after injury progressed.
Johnson
D
D
Department of Psychology, Atkinson Morley's Hospital, UK.
Roethig-Johnston
K
K
Richards
D
D
D000110:Acetylcholinesterase / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D001925:Brain Damage, Chronic / Q000401:mortality / Q000503:physiopathology*; D002395:Catecholamines / Q000502:physiology; D005260:Female; D015600:Glasgow Coma Scale; D016489:Head Injuries, Closed / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D009460:Neurologic Examination; D018377:Neurotransmitter Agents / Q000502:physiology*; D011379:Prognosis; D012701:Serotonin / Q000502:physiology; D015996:Survival Rate; D009435:Synaptic Transmission / Q000502:physiology*
D002395:Catecholamines; D018377:Neurotransmitter Agents; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D000110:Acetylcholinesterase