New biomaterials through surface segregation phenomenon: new quaternary ammonium compounds as antibacterial agents.
Five new trisiloxane quaternary ammonium compounds were synthesized from hydrotrisiloxane with allyl glycidyl ether to yield the epoxy function. Various amines were then reacted to yield trisiloxane amines which were further reacted to methyl substitute or oxidize the beta-carbons in order to provide thermal stability. These new compounds were employed as melt additives in a nonwoven polypropylene fiber extrusion process to produce, through surface segregation, a new biomaterial with antibacterial properties.
Nohr
R S
RS
Kimberly-Clark Corporation, Roswell, GA 30076.
Macdonald
J G
JG
D000588:Amines / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D004926:Escherichia coli / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012833:Siloxanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013499:Surface Properties
D000588:Amines; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D000644:Quaternary Ammonium Compounds; D012833:Siloxanes