[Biosynthetic growth hormone extracted from mammalian cells used in the management of growth hormone deficient children].
Biosynthetic growth hormone extracted from mammalian cells was used in eight children with growth hormone deficiency, in search for a clinical safety study. Each child received 0.6 U/kg/week, subcutaneously, during a period of six months, and was evaluated monthly for clinical, anthropometric and laboratory modifications induced by the drug in a physiological or pathological way. The growth velocity increased from less that 4 cm/year to 11.2 +/- 1.08 cm/year, the bone age maintained according to the chronological age, and the anthropometric evaluation showed an harmonious and physiological growth. There was not any undesirable nor secondary changes except transient hypothyroidism in two patients, and unmasked hypophyseal hypothyroidism in another two. We concluded that biosynthetic growth hormone extracted from mammalian cells is a safety drug, and that patients with growth hormone deficiency may be treated with it in order to improve their final height expectancy.
Calzada-León
R
R
Unidad de Crecimiento, Instituto Nacional de Pediatría, México, D.F.
Altamirano
N
N
Llanas
D
D
Páras
G
G
Robles-Váldes
C
C
D000293:Adolescent; D000365:Age Determination by Skeleton; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000188:drug therapy / Q000378:metabolism*; D013006:Growth Hormone / Q000008:administration & dosage / Q000096:biosynthesis* / Q000627:therapeutic use; D013007:Growth Hormone-Releasing Hormone / Q000172:deficiency*; D006801:Humans; D008297:Male; D008322:Mammals / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism
D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone
Hormona de crecimiento biosintética, extraída de células de mamífero en el manejo de niños con deficiencia de hormona de crecimiento.