Glucose strongly stimulates rate of the rRNA synthesis in Ehrlich ascites carcinoma cells.
A change in glucose concentration in an Ehrlich ascites carcinoma cell suspension from 0.1 mM to 20 mM causes a more than 50-fold stimulation of the rate of ribosomal RNA synthesis. Such an effect occurs without any dramatic effect on the rate of protein synthesis in cells. This process parallels a decrease in intracellular pH which may be a reason of Na+/H(+)-antiport activation.
Buzhurina
I M
IM
Laboratory of Cell Physiology, A.N. Belozersky Institute of Physical and Chemical Biology, Moscow State University, Russia.
Chernaya
N G
NG
Panov
M A
MA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012322:RNA Precursors / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism
D009363:Neoplasm Proteins; D012322:RNA Precursors; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D017923:Sodium-Hydrogen Exchangers; D000255:Adenosine Triphosphate; D005947:Glucose