title: Induction of matrix protein synthesis in human glomerular mesangial cells by the terminal complement complex.
abstract: Exposure of human glomerular mesangial cells (GMC) in culture to sublytic doses of the terminal complement proteins C5b-8 and C5b-9 caused a transient increase in abundance of mRNA specific for collagen type IV and fibronectin; mRNA of laminin was not affected. Since C5b-9 is found deposited in inflamed or sclerotic areas we propose that stimulation of matrix protein synthesis by C5b-9 might contribute to the development of glomerular sclerosis.
authors.affiliation: Institut für Immunologie, Universität Heidelberg, BRD.
authors.forename: C
authors.initials: C
authors.lastname: Wagner
authors.forename: M
authors.initials: M
authors.lastname: Braunger
authors.forename: M
authors.initials: M
authors.lastname: Beer
authors.forename: K
authors.initials: K
authors.lastname: Rother
authors.forename: G M
authors.initials: GM
authors.lastname: Hänsch
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D003094:Collagen / Q000096:biosynthesis / Q000235:genetics; D015938:Complement Membrane Attack Complex / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis*; D005353:Fibronectins / Q000235:genetics; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D007797:Laminin / Q000235:genetics; D010879:Piperazines / Q000494:pharmacology; D011392:Proline / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D015938:Complement Membrane Attack Complex; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D007546:Isoquinolines; D007797:Laminin; D010879:Piperazines; D012333:RNA, Messenger; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D003094:Collagen; D003513:Cycloheximide; D011392:Proline; D011493:Protein Kinase C