title: Olfactory deficits in neuroleptic naive patients with schizophrenia.
abstract: Because previous studies have shown deficits in olfactory identification for male patients with schizophrenia, either withdrawn from or receiving neuroleptic medication, the purpose of the current study was to determine if such deficits occurred in male patients who had never received neuroleptics. A sample of male (n = 30) and female (n = 10) patients as well as age appropriate controls (males, n = 28, females, n = 30) was assessed in terms of olfactory acuity and identification ability. No differences were found in olfactory acuity, but an olfactory identification deficit was present in 31% of the male patients with schizophrenia. As the olfactory pathways project through the limbic system and to the orbitofrontal cortex, odour identification may be a measure of the functional integrity of these structures. Therefore, these results suggest that for a sub-sample of male patients, the functional integrity of these structures is compromised.
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: L C
authors.initials: LC
authors.lastname: Kopala
authors.forename: C
authors.initials: C
authors.lastname: Clark
authors.forename: T
authors.initials: T
authors.lastname: Hurwitz
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001931:Brain Mapping; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects / Q000503:physiopathology; D009833:Olfactory Pathways / Q000187:drug effects / Q000503:physiopathology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents