Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum.
Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.
Yu
L
L
Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian.
Ma
R
R
Wang
Y
Y
Nishino
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000633:toxicity; D004365:Drugs, Chinese Herbal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D012503:Saponins / Q000494:pharmacology* / Q000633:toxicity; D014315:Triterpenes / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C051084:tubeimoside I