Brain glucose metabolism in Alzheimer's disease.
In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer's disease showed a marked decrease when compared with nondemented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-dependent decline in the rate of glucose use. These data provide an in vitro correlate for positron emission tomography studies that suggest decreased brain glucose use in Alzheimer's disease.
Swerdlow
R
R
Department of Medicine, NYU Medical Center, NY 10016.
Marcus
D L
DL
Landman
J
J
Kooby
D
D
Frey
W
W
Freedman
M L
ML
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D013702:Temporal Lobe / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D005947:Glucose