title: Post-antibiotic effects of cefdinir on Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyrogenes.
abstract: The post-antibiotic effects (PAEs) of a new cephalosporin, cefdinir, were determined against a range of organisms using a viable counting technique. Cefdinir exerted considerable PAEs against Staphylococcus aureus and Streptococcus pyogenes, but no overall post-antibiotic inhibition of growth was detected against Escherichia coli or Klebsiella pneumoniae. Exposure to cefdinir made the gram-negative organisms susceptible to the washing procedure used for drug removal, but this was followed by rapid recovery of viability in drug-free broth.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, University of London, UK.
authors.forename: B M
authors.initials: BM
authors.lastname: Howard
authors.forename: R J
authors.initials: RJ
authors.lastname: Pinney
authors.forename: J T
authors.initials: JT
authors.lastname: Smith
mesh_terms: D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000254:growth & development
chemical_list: D002511:Cephalosporins; D000077525:Cefdinir