Characteristics of an attenuated vaccinia virus strain, LC16m0, and its recombinant virus vaccines.
This article reviews studies concerning the characteristics of a vaccinia virus strain, LC16m0, and its recombinant virus vaccines. The LC16m0 strain is one of several temperature-sensitive and further attenuated variants derived from the Lister (Elstree) strain of vaccinia virus, which has a proven safety record in human populations. Several types of recombinant vaccinia viruses expressing a foreign antigen gene from a pathogenic virus have been constructed using the LC16m0 strain as a vector, and their immunological and virological characteristics have been investigated extensively. These studies indicate that the LC16m0 strain has potential as a vector in a live recombinant vaccine. The advantages, disadvantages and future prospects of vector are discussed.
Sugimoto
M
M
Department of Preventive Medicine, Nagasaki University, Japan.
Yamanouchi
K
K
D017325:Hepatitis B Vaccines / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000276:immunology; D012302:Rinderpest virus / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology*; D014616:Vaccinia virus / Q000472:pathogenicity*; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
D017325:Hepatitis B Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines