The sigma receptor ligand SR 31742A increases neurotensin in the nucleus accumbens but not in the caudate-putamen of the rat.
The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.
Labie
C
C
Sanofi Recherche, Toulouse, France.
Keane
P E
PE
Soubrié
P
P
Le Fur
G
G
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001381:Azepines / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D009496:Neurotensin / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D011699:Putamen / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D014150:Antipsychotic Agents; D001381:Azepines; C080238:3-(hexahydroazepin-1-yl)-1-(3-chloro-4-cyclohexylphenyl)-1-propene hydrochloride; D009496:Neurotensin; D006220:Haloperidol