Detection of high-risk human papillomavirus in the cervix and semen of sex partners.
To investigate the possibility of sexual transmission of human papillomavirus (HPV), 53 married couples were examined for the presence of HPV-16 and -18 DNAs in the uterine cervix and semen using the polymerase chain reaction method. Twenty-three of the 53 women and 12 of the 53 male partners were positive for HPV-16 DNA. No HPV-18 DNA was detected in samples from any of the partners. In 27 pairs, both partners were negative for HPV DNA in cervix or semen; in the remaining 26 pairs, at least 1 of the partners was HPV-16-positive. In 9 (35%) of these 26 pairs, both partners were infected. Furthermore, 9 (75%) of the 12 women with HPV-positive partners were HPV-positive, while 9 (39%) of the 23 men with HPV-positive female partners were HPV-positive. These findings suggest an increased risk of HPV transmission via sexual intercourse, thereby underscoring the importance of preventive care against HPV infection during intercourse.
Kyo
S
S
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Inoue
M
M
Koyama
M
M
Fujita
M
M
Tanizawa
O
O
Hakura
A
A
D000328:Adult; D001483:Base Sequence; D002584:Cervix Uteri / Q000821:virology*; D017931:DNA Primers; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008393:Marriage; D008875:Middle Aged; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission; D016133:Polymerase Chain Reaction / Q000379:methods*; D011897:Random Allocation; D012307:Risk Factors; D012661:Semen / Q000821:virology*; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission
D017931:DNA Primers; D004279:DNA, Viral