Detection of HTLV-I and HTLV-II infection in Africans using type-specific envelope peptides.
Antibodies to HTLV were determined in 4,630 black African individuals from Zaire, Ghana and South Africa; 185 (4%) were confirmed as seropositive. Seroprevalance was 0.2% in a group of South African women, 0.9% among Ghanaian refugees in Belgium and from less than 1% to over 15% in various sites and populations in Zaire. With the use of HTLV-I and HTLV-II type-specific envelope peptides, 93% of confirmed HTLV seropositives were classified as HTLV-I. Five persons from the Haut Zaire region had HTLV-II serological reactivities, suggesting the presence of HTLV-II or a related retrovirus in central Africa. A cluster of HTLV-I-like indeterminate western blot patterns lacking anti-p24 antibody was found in Bas Zaire.
Goubau
P
P
Department of Microbiology, Rega Institute, Leuven, Belgium.
Desmyter
J
J
Swanson
P
P
Reynders
M
M
Shih
J
J
Surmont
I
I
Kazadi
K
K
Lee
H
H
D001530:Belgium / Q000453:epidemiology; D015153:Blotting, Western; D015480:Deltaretrovirus Antibodies / Q000097:blood* / Q000276:immunology; D015485:Deltaretrovirus Antigens / Q000032:analysis / Q000276:immunology*; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005260:Female; D015686:Gene Products, env / Q000276:immunology; D005869:Ghana / Q000453:epidemiology / Q000208:ethnology; D015490:HTLV-I Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D015491:HTLV-II Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D015367:Human T-lymphotropic virus 2 / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D015682:Retroviridae Proteins, Oncogenic / Q000276:immunology; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D013019:South Africa / Q000453:epidemiology; D014759:Viral Envelope Proteins / Q000276:immunology; D054299:env Gene Products, Human Immunodeficiency Virus
D015480:Deltaretrovirus Antibodies; D015485:Deltaretrovirus Antigens; D015686:Gene Products, env; D015682:Retroviridae Proteins, Oncogenic; D014759:Viral Envelope Proteins; D054299:env Gene Products, Human Immunodeficiency Virus; C055266:gp46 protein, Human T-cell leukemia virus type I; C069568:gp46 protein, Human immunodeficiency virus 2