Longitudinal study of the effect of calcium pidolate on bone mass in eugonadal women.
Seventy-two eugonadal women, mean age 39 +/- 4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80 +/- 0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distributed into two groups: 36 women undergoing treatment with 1 g/day of elemental calcium in the form of calcium pidolate and 36 women not treated. One year later, total body BMC, regional BMC in arms, legs and trunk, 24-hour urinary calcium excretion (Ca 24 hour), fasting urinary calcium/creatinine ratio, and serum tartrate-resistant acid phosphatase concentration were measured in both groups. There was a significant increase in total body and regional BMC (P < 0.001) in the group taking calcium pidolate. The increase was greater in arms and legs (2.5%) than in trunk (1.7%), being 2.6% for total body BMC. The z score increased from -1.81 +/- 0.13 to -1.52 +/- 0.12 (16%, P < 0.001). The corporal index did not change, and total body BMC corrected for fat-free body mass increased by 6.7% (P < 0.001). These changes were accompanied by an increase in 24-hour urinary calcium excretion and a decrease in urinary calcium/creatinine ratio and serum tartrate-resistant acid phosphatase concentration (P < 0.05 for all). There was a correlation between cumulative calcium dose at the end of treatment and gain in total body BMC (r2 = 0.925, P < 0.001). The untreated group showed no changes.(ABSTRACT TRUNCATED AT 250 WORDS)
Rico
H
H
Department of Medicine, Príncipe de Asturias Hospital, Alcalá de Henares University, Madrid, Spain.
Revilla
M
M
Villa
L F
LF
Alvarez de Buergo
M
M
Arribas
I
I
D015502:Absorptiometry, Photon; D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*; D002118:Calcium / Q000652:urine; D003401:Creatine / Q000652:urine; D005260:Female; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D010053:Ovary / Q000502:physiology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D013131:Spine / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology
D000135:Acid Phosphatase; D003401:Creatine; D002118:Calcium; D011761:Pyrrolidonecarboxylic Acid