title: beta-Lactamase inhibitors derived from N-tosyloxy-beta-lactams.
abstract: Electrophilic N-tosyloxy-beta-lactams, N-tosyloxy-4-phenyl-2-azetidinone (2b) and N-tosyloxy-3-(S)-phthalimido-4-(S)-2-azetidinone (2c), are described. These agents are novel potent beta-lactamase inhibitors.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556.
authors.forename: M
authors.initials: M
authors.lastname: Teng
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
authors.forename: T I
authors.initials: TI
authors.lastname: Nicas
authors.forename: J
authors.initials: J
authors.lastname: Grissom-Arnold
authors.forename: R D
authors.initials: RD
authors.lastname: Cooper
mesh_terms: D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014105:Tosyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
chemical_list: D001384:Azetidines; C089353:N-tosyloxy-3-phthalimido-4-methyl-2-azetidinone; C089352:N-tosyloxy-4-phenyl-2-azetidinone; D010797:Phthalimides; D014105:Tosyl Compounds; D065093:beta-Lactamase Inhibitors