title: Pathophysiology of hearing impairment in acoustic neuroma with profound deafness: analysis by evoked otoacoustic emission and promontory stimulation test.
abstract: Evoked otoacoustic emissions (e-OAEs) were examined and promontory stimulus test (PST) done prior to tumor removal in 15 cases of surgically proven unilateral acoustic neuroma (AN) with more than 80 dB in pure-tone hearing level. The e-OAEs were elicited by tone-bursts at 1 kHz and 2 kHz, and an interaural difference in pseudothreshold of more than 10 dB was defined as a significant impairment of the cochlear function. In PST, electrical stimulation was applied by a burst mode at 6 stimulus frequencies between 50 Hz and 1600 Hz. The number of stimulus frequencies with a positive response was defined as the PST score. The results obtained were as follows; i) Mean interaural difference in e-OAE pseudothreshold was 16.0 dB at 1 kHz and 8.0 dB at 2 kHz, ii) Positive PST was found in only 40% of the subjects and the mean PST score was 0.93, iii). When the pathophysiology of hearing impairment was inferred from the combination of the findings in e-OAEs and PST, it was found that 33.3% of the subjects had pure cochlear impairment, 13.3% pure retrocochlear impairment and 46.7% cochlear-retrocochlear impairment. It is concluded that analysis of both e-OAEs and PST could clarify the pathophysiology of hearing impairment in AN with profound deafness, which cannot be determined by conventional psychoacoustic tests.
authors.affiliation: Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: O-Uchi
authors.forename: J
authors.initials: J
authors.lastname: Kanzaki
authors.forename: A
authors.initials: A
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Mashino
authors.forename: S
authors.initials: S
authors.lastname: Yoshihara
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D001307:Auditory Perception / Q000502:physiology*; D001309:Auditory Threshold / Q000502:physiology*; D003051:Cochlea / Q000503:physiopathology*; D003055:Cochlear Microphonic Potentials / Q000502:physiology; D003638:Deafness / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006309:Hearing / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000503:physiopathology*