title: Resistance to nitroprusside neurotoxicity in perinatal rat brain.
abstract: Nitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the N-methyl-D-aspartate (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks at postnatal day 7. To assess whether NO toxicity exhibits a similar developmental profile, we injected the NO generator sodium nitroprusside into the immature and adult rodent hippocampal formation and striatum, using a dose known to damage the adult nervous system. Contrary to our expectations, we found the immature brain highly resistant to the toxic effects of sodium nitroprusside.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor.
authors.forename: W F
authors.initials: WF
authors.lastname: Maragos
authors.forename: F S
authors.initials: FS
authors.lastname: Silverstein
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology*; D006624:Hippocampus / Q000254:growth & development / Q000473:pathology; D007267:Injections; D008297:Male; D017072:Neostriatum / Q000254:growth & development / Q000473:pathology; D009599:Nitroprusside / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009599:Nitroprusside