Changes in urinary excretion of endothelin-1-like immunoreactivity before and after unilateral nephrectomy in humans. Comparison with other urinary parameters and unilateral adrenalectomy.
To assess the value of endothelin-1 (ET-1) as a parameter of renal functional overload and the process of hyperfiltration, urinary excretion of ET-1-like immunoreactivity (U-ET-1) and urinary excretion of other parameters [beta 2-microglobulin (beta 2-MG), N-acetyl-beta-D-glucosaminidase (NAG), albumin (Alb) and 24-hour creatinine clearance (Ccr24)] were measured before, 1, 2 and 7 days after unilateral nephrectomy in 15 patients with unilateral renal lesions (renal cell cancer, renal pelvic cancer, ureteral cancer and renal tuberculosis) and after unilateral adrenalectomy in 5 patients with adrenal lesions. In the nephrectomy group (NX), Ccr24 significantly decreased at 1 and 2 days after the operation, but the other 4 parameters significantly increased after the operation as compared to preoperative values. In the adrenalectomy group (ADX), neither Ccr24 nor ET-1/Cr showed any change after the operation, but the other 3 parameters (beta 2-MG/Cr, NAG/Cr and Alb/Cr) significantly increased. Comparing the NX and ADX groups, both ET-1/Cr and beta 2-MG/Cr in NX were significantly higher than in ADX after the operation. On the other hand, neither NAG/Cr nor Alb/Cr in NX differed from values in ADX. Comparing ET-1/Cr and other parameters, only beta 2-MG showed a positive significant correlation. These results suggest that U-ET-1 may be an indicator of functional overload of the kidney.
Takeda
M
M
Department of Urology, Niigata University School of Medicine, Japan.
Komeyama
T
T
Tsutsui
T
T
Mizusawa
T
T
Katayama
Y
Y
Go
H
H
Tamaki
M
M
Hatano
A
A
D000118:Acetylglucosaminidase / Q000652:urine; D000311:Adrenal Glands / Q000502:physiology / Q000601:surgery; D000315:Adrenalectomy; D000368:Aged; D000419:Albuminuria / Q000209:etiology / Q000652:urine; D003404:Creatinine / Q000652:urine; D016232:Endothelins / Q000276:immunology* / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D009399:Nephrons / Q000502:physiology; D001613:beta 2-Microglobulin / Q000652:urine
D016232:Endothelins; D001613:beta 2-Microglobulin; D003404:Creatinine; D000118:Acetylglucosaminidase