Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism.
We tested for an association between autism and genes coding for enzymes involved in monoaminergic metabolism and for a linked marker, c-Harvey-Ras-1 (HRAS 1), using restriction fragment length polymorphisms. We did not find evidence of an association between autism and genes coding for tyrosine hydroxylase, dopamine-beta-hydroxylase (DBH), and tryptophan hydroxylase. However, we report a positive association between autism and the locus containing the gene for HRAS-1.
Hérault
J
J
National Institute for Health and Medical Research, Tours, France.
Perrot
A
A
Barthélémy
C
C
Büchler
M
M
Cherpi
C
C
Leboyer
M
M
Sauvage
D
D
Lelord
G
G
Mallet
J
J
Müh
J P
JP
D000293:Adolescent; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
D005819:Genetic Markers; D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase; D004299:Dopamine beta-Hydroxylase; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)