Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748.
Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central alpha 1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few alpha 1-agonists have been tested to date using the systemic route of exposure, the present study examined the effects of the alpha 1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50 = 0.49 mg/kg) and water intake (ED50 = 0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50 = 0.37 mg/kg) and was less potent in suppressing water intake (ED50 = 0.76 mg/kg). These results document that systemic injection of the alpha 1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of alpha 1-adrenoceptors suppresses food intake.
Morien
A
A
Department of Psychology, Texas A&M University, College Station 77843-4235.
McMahon
L
L
Wellman
P J
PJ
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects*; D004983:Ethanolamines / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D004983:Ethanolamines; D013764:Tetrahydronaphthalenes; C016980:amidephrine; C039140:SK&F 89748