Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.
In hypophysectomized and thyroidectomized rats, cytosolic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase activity, immunoreactive protein and mRNA levels were all considerably decreased. Administration of L-tri-iodothyronine (T3) resulted in a large increase in all three in hypophysectomized rats and in only a 2-fold increase (reaching the values of control rats) in thyroidectomized rats.
Royo
T
T
Unit of Biochemistry, University of Barcelona, School of Pharmacy, Spain.
Haro
D
D
Hegardt
F G
FG
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D007016:Hypophysectomy; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013965:Thyroidectomy; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology*
D012333:RNA, Messenger; D014284:Triiodothyronine; D006904:Hydroxymethylglutaryl-CoA Synthase