Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke.
To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 +/- 15.6 ng ml-1) compared to controls (257.7 +/- 24.8) and risks (257.7 +/- 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 +/- 4.3%; n = 14) compared to controls (9.7 +/- 2.3%; n = 12) and risks (12.7 +/- 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occurring in acute stroke.
Clark
W M
WM
Department of Neurology, Oregon Health Sciences University, Portland 97201.
Coull
B M
BM
Briley
D P
DP
Mainolfi
E
E
Rothlein
R
R
D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000097:blood*; D002561:Cerebrovascular Disorders / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007797:Laminin; D009504:Neutrophils / Q000502:physiology*; D012307:Risk Factors
D015815:Cell Adhesion Molecules; D007797:Laminin; D018799:Intercellular Adhesion Molecule-1