title: Synthesis and nematocidal activity of arylmercaptovinyltetrahydropyrimidines.
abstract: A set of mercaptovinyl tetrahydropyrimidines was synthesized in good yields by lithiation of 1,2-dimethyltetrahydropyrimidine with n-butyl lithium in tetrahydrofurane, followed by condensation with aromatic thioesters. Against three nematode genera, anthelminthic screening shows little activity; 2b and 2d were the most potent against Molinema dessetae.
authors.affiliation: Département de Chimie, Faculté de Pharmacie, Toulouse.
authors.forename: N
authors.initials: N
authors.lastname: Kraouti
authors.forename: S
authors.initials: S
authors.lastname: Labidalle
authors.forename: R
authors.initials: R
authors.lastname: Caujolle
authors.forename: M
authors.initials: M
authors.lastname: Payard
authors.forename: C
authors.initials: C
authors.lastname: Bories
authors.forename: P M
authors.initials: PM
authors.lastname: Loiseau
authors.forename: P
authors.initials: P
authors.lastname: Gayral
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000969:Antinematodal Agents; D011743:Pyrimidines