[A study on nephrotoxicity of arbekacin and vancomycin in rats].
Nephrotoxicities of arbekacin (ABK) and/or vancomycin (VCM) were examined by administrating rats intravenously with single doses or 10 times repeated daily doses. ABK was found less toxic to kidney than VCM, and the toxicity was strengthened by combined treatment with VCM and ABK. Fosfomycin decreased the nephrotoxicity when added to the single or combined treatment with ABK and VCM.
Niizato
T
T
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
Ohnishi
M
M
Nishiyama
S
S
Asaoka
H
H
Saito
A
A
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D003982:Dibekacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000633:toxicity; D005578:Fosfomycin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014640:Vancomycin / Q000633:toxicity*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D003982:Dibekacin; D014640:Vancomycin; C031986:arbekacin