Lupus erythematosus-like syndrome induced by thiamazole and propylthiouracil.
A 17-year-old Japanese woman developed a lupus erythematosus-like syndrome during treatment for Graves' disease with thiamazole and propylthiouracil. Erythema, arthralgia, and low grade fever developed during therapy with thiamazole; purplish-red erythema developed during therapy with propylthiouracil. Antinuclear antibodies, anti-single-stranded DNA antibodies, and anti-double-stranded DNA antibodies were positive throughout the administration of these two drugs. Eruptions and other symptoms improved after their discontinuation. The titers of autoantibodies also decreased two months after withdrawal. The patient had HLA DR4.
Sato-Matsumura
K C
KC
Department of Dermatology, Hokkaido University, Japan.
Koizumi
H
H
Matsumura
T
T
Takahashi
T
T
Adachi
K
K
Ohkawara
A
A
D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000276:immunology; D004277:DNA, Single-Stranded / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008713:Methimazole / Q000009:adverse effects*; D011441:Propylthiouracil / Q000009:adverse effects*; D012882:Skin Tests
D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D007075:Immunoglobulin M; D008713:Methimazole; D011441:Propylthiouracil; D004247:DNA