Identification of a cross-reactive allergen (presumably tropomyosin) in shrimp, mite and insects.
A monoclonal antibody to Dermatophagoides pteronyssinus is described that cross-reacts with an IgE-binding antigen present in insects, Crustacea (e.g. shrimp) and other invertebrates. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gel filtration and immunofluorescence it was shown that this monoclonal antibody presumably recognizes tropomyosin. Tropomyosin was shown to be involved in cross-reactivity between mite, shrimp and insects in shrimp-allergic patients.
Witteman
A M
AM
Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam.
Akkerdaas
J H
JH
van Leeuwen
J
J
van der Zee
J S
JS
Aalberse
R C
RC
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D003429:Cross Reactions; D033364:Decapoda / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007313:Insecta / Q000276:immunology*; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test; D014335:Tropomyosin / Q000276:immunology*
D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D014335:Tropomyosin; C026408:anti-IgE antibodies; D007073:Immunoglobulin E