Multiple adenovirus serotypes use alpha v integrins for infection.
The nucleotide sequence encoding the penton base integrin-binding domains of several human adenoviruses was obtained by homology PCR. Each of the penton base proteins contains a conserved Arg-Gly-Asp (RGD) sequence that is predicted to lie at the apex of two extended alpha helices. The penton base RGD domain promotes efficient infection of host cells by multiple adenovirus serotypes via interaction with alpha v integrins, thus indicating that alpha v integrins play a central role in the entry of adenoviruses into host cells.
Mathias
P
P
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.
Wickham
T
T
Moore
M
M
Nemerow
G
G
D000260:Adenoviruses, Human / Q000235:genetics / Q000502:physiology*; D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D002213:Capsid / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D036022:Capsid Proteins; D002460:Cell Line; D017931:DNA Primers; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008961:Models, Structural; D008969:Molecular Sequence Data; D009842:Oligopeptides; D016133:Polymerase Chain Reaction / Q000379:methods; D017433:Protein Structure, Secondary; D017386:Sequence Homology, Amino Acid
D036022:Capsid Proteins; D017931:DNA Primers; D016023:Integrins; D009842:Oligopeptides; C043322:penton protein, adenovirus; C047981:arginyl-glycyl-aspartic acid