Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: implications for prevention of osteoporosis.
In 14 women aged 37-68 y with a history of renal calcium calculi, bone densities were 12.0% below those of age-matched control subjects at the L2-4 lumbar spine (P = 0.007) and 6.4% less at the femoral neck (P = 0.095). A low-oxalate diet was supplemented with 1 g Ca/d as citrate. In 6 mo, plasma 1,25(OH)2D concentrations fell from 53.2 +/- 18.8 to 41.9 +/- 15.2 ng/L (P = 0.02) and parathyroid hormone from 39.1 +/- 17.0 to 30.8 +/- 12.5 ng/L (P = 0.02). Calcium oxalate saturation was 2.15 +/- 1.38 at baseline, 2.27 +/- 1.00 at 1 mo, and 2.06 +/- 1.57 at 6 mo. The increase in urinary calcium at 1 mo from 4.411 +/- 1.87 to 6.514 +/- 2.82 mmol/24 h (P = 0.01) was offset by a parallel increase in citrate excretion from 2.909 +/- 1.45 to 3.455 +/- 1.34 mmol/24 h (P = 0.03). Calcium citrate supplementation did not increase the lithogenicity of the women in this protocol.
Levine
B S
BS
Department of Medicine, Cornell University Medical College, New York, NY.
Rodman
J S
JS
Wienerman
S
S
Bockman
R S
RS
Lane
J M
JM
Chapman
D S
DS
D000328:Adult; D000368:Aged; D015519:Bone Density; D002118:Calcium / Q000652:urine; D002129:Calcium Oxalate / Q000652:urine*; D002951:Citrates / Q000009:adverse effects* / Q000627:therapeutic use / Q000652:urine; D019343:Citric Acid; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced / Q000652:urine*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D013997:Time Factors
D002951:Citrates; D002129:Calcium Oxalate; D019343:Citric Acid; D002118:Calcium