No association of multiple sclerosis to alleles at the TAP2 locus.
MS is associated with genes in the HLA complex. We have previously proposed that the primary HLA-associated susceptibility may be conferred by particular DQ alleles. Furthermore, we have previously found that there is no association of MS to DP alleles. This study shows that MS is not associated to alleles of the TAP2 locus, which is located close to DQ on its centromeric side. This observation provides further support to the notion that HLA-associated susceptibility to MS maps telomeric to the TAP2 locus.
Spurkland
A
A
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
Knutsen
I
I
Undlien
D E
DE
Vartdal
F
F
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D000483:Alleles; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004198:Disease Susceptibility; D008040:Genetic Linkage; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; C071692:TAP2 protein, human; D004247:DNA