Insulin prophylaxis in individuals at high risk of type I diabetes.
Prevention of type I diabetes is now a practical goal thanks to the ability to define confidently a high-risk group and the success of preventive strategies in animal models. We describe here a pilot trial of low-dose insulin to prevent diabetes in relatives of patients with type I diabetes.
Keller
R J
RJ
Division of Endocrinology, Children's Hospital, Boston, MA 02115.
Eisenbarth
G S
GS
Jackson
R A
RA
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000097:blood; D007515:Islets of Langerhans / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008019:Life Style; D015993:Life Tables; D008297:Male; D008403:Mass Screening; D010375:Pedigree; D010865:Pilot Projects; D011322:Primary Prevention / Q000379:methods / Q000592:standards*; D012307:Risk Factors; D016896:Treatment Outcome
D001323:Autoantibodies; D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies