Search for a schizophrenia susceptibility locus on human chromosome 22.
We used 10 highly informative DNA polymorphic markers and genetic linkage analysis to examine whether a gene locus predisposing to schizophrenia is located on chromosome 22, in 105 families with schizophrenia and schizoaffective disorder. The LOD score method, including analysis for heterogeneity, provided no conclusive evidence of linkage under a dominant, recessive, or penetrance free model of inheritance. Affected sib-pair analysis was inconclusive. Affected pedigree member analysis gave only suggestive evidence for linkage. Multipoint APM analysis, using 4 adjacent loci including D22S281 and IL2RB, a region of interest from the APM analysis, gave non-significant results for the three different weighting functions.
Polymeropoulos
M H
MH
Laboratory of Biochemical Genetics, NIMH, Washington, District of Columbia.
Coon
H
H
Byerley
W
W
Gershon
E S
ES
Goldin
L
L
Crow
T J
TJ
Rubenstein
J
J
Hoff
M
M
Holik
J
J
Smith
A M
AM
D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*