Serum creatine phosphokinase elevations in patients with tardive dyskinesia.
We describe a case of marked increases in serum creatine phosphokinase (CPK) associated with a dramatic exacerbation of tardive dyskinesia (TD). Chart review of eight additional patients with severe TD revealed three cases with mild CPK elevations. These cases suggest that TD, especially when accompanied by dystonia, may be associated with pathology of striated muscle.
Egan
M F
MF
Neuropsychiatry Branch, NIMH Neuroscience Research Center, St Elizabeth's, Washington, DC 20032.
Dargham
A A
AA
Kirch
D G
DG
Wyatt
R J
RJ
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood*; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000201:enzymology* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy* / Q000201:enzymology; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D003402:Creatine Kinase