Differential expression of interleukin-6, intracellular adhesion molecule 1, and major histocompatibility complex class II molecules in renal carcinoma cells stimulated with S fimbriae of uropathogenic Escherichia coli.
The production of interleukin-6, intracellular adhesion molecule 1, and major histocompatibility complex class II molecules by a renal carcinoma cell line (ACHN) in response to S fimbriae of uropathogenic Escherichia coli was studied. S fimbriae adhered to ACHN cells and stimulated the production of interleukin-6 and intercellular adhesion molecule 1 but did not affect major histocompatibility complex class II expression by renal carcinoma cells. Our data demonstrate that S fimbriae of E. coli display immunomodulating properties on kidney-derived epithelial cells.
Kreft
B
B
Klinik für Innere Medizin, Medizinischen Universität zu Lübeck, Germany.
Bohnet
S
S
Carstensen
O
O
Hacker
J
J
Marre
R
R
D002292:Carcinoma, Renal Cell / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D004926:Escherichia coli / Q000472:pathogenicity*; D010861:Fimbriae, Bacterial / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis*; D007680:Kidney Neoplasms / Q000276:immunology*; D014407:Tumor Cells, Cultured
D015815:Cell Adhesion Molecules; D000949:Histocompatibility Antigens Class II; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma