Forensic investigation of gentamicin sulfates by anion-exchange ion chromatography with pulsed electrochemical detection.
Many methods exist for the separation of gentamicin C complex components, C1, C1a, C2 and C2a. In an investigation of possible counterfeit suppliers of gentamicin sulfate, a new method utilized high-pH anion-exchange separation on a carbohydrate column, with pulsed electrochemical detection on a gold electrode. Component ratios and the presence and/or absence of additional peaks were used to link or dissociate forensic samples.
Kaine
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US Food and Drug Administration, National Forensic Chemistry Center, Cincinnati, OH 45202.
Wolnik
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D000837:Anion Exchange Resins; D002240:Carbohydrate Sequence; D002852:Chromatography, Ion Exchange / Q000379:methods*; D004304:Dosage Forms; D004563:Electrochemistry; D005554:Forensic Medicine; D005839:Gentamicins / Q000008:administration & dosage / Q000032:analysis*; D008969:Molecular Sequence Data
D000837:Anion Exchange Resins; D004304:Dosage Forms; D005839:Gentamicins