13C-NMR assignments and cytotoxicity assessment of zoanthoxanthin alkaloids from zoanthid corals.
Zoanthoxanthin alkaloids can vary among skeletal types A, B, and C. Three type C zoanthoxanthins were examined, including a new compound 1, previously reported paragracine [2], and zoanthoxanthin 3. Their nmr and cytotoxic properties are reported. We have used 2D nmr data to complete the assignments for 1 and suggest that these benchmark nmr assignments will allow future investigators to establish new metabolites of this class as a member of families A, B, or C with only a 13C APT and a 1H-1H nmr spectra.
Jiménez
C
C
Department of Chemistry and Biochemistry, University of California, Santa Cruz 65064.
Crews
P
P
D000470:Alkaloids / Q000032:analysis* / Q000633:toxicity; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D006801:Humans; D007093:Imidazoles / Q000032:analysis* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D007093:Imidazoles; C009702:zoanthoxantin