Synthesis of new C-19-functionalized cholesterols.
A series of new derivatives of cholesterol bearing polar functional groups on carbon-19 were synthesized, including 19-oximino-, 19-amino-, 19-(methylamino)-, 19-mercapto-, and 19-(methylthio) cholesterol, and 3 beta-hydroxycholest-5-en-19-oic acid, as well as an unusual cyclosterol, 5,19-cyclocholest-6-en-3 beta-ol.
Mathai
M S
MS
Department of Chemistry, Princeton University, NJ 08544.
Pascal
R A
RA
D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008958:Models, Molecular; D015394:Molecular Structure; D013261:Sterols / Q000138:chemical synthesis*
D013261:Sterols; D002784:Cholesterol