title: Serotonin immunoreactivity in the carotid body of adult humans.
abstract: The distribution of serotonin immunoreactivity (-IR) was studied in adult human carotid bodies, obtained at post-mortem, using both the peroxidase-antiperoxidase method on paraffin sections and a double-labelling immunofluorescence on frozen sections. Antibodies against synaptophysin and protein gene product (PGP) 9.5 were used for identification of serotonin-IR cells. Serotonin-IR was demonstrable in the carotid bodies of adult humans and it was coexpressed mostly with synaptophysin or PGP 9.5 in type I cells. Some serotonin immunopositive type I cells were located in close proximity to capillaries. Serotonin-IR was also observed in a few endothelial cells.
authors.affiliation: Institute of Pathology, Muncipal Hospital, Chemnitz, Germany.
authors.forename: J O
authors.initials: JO
authors.lastname: Habeck
authors.forename: D J
authors.initials: DJ
authors.lastname: Pallot
authors.forename: W
authors.initials: W
authors.lastname: Kummer
mesh_terms: D000293:Adolescent; D000368:Aged; D002344:Carotid Body / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D016612:Paraffin Embedding; D012701:Serotonin / Q000276:immunology / Q000378:metabolism*; D016708:Synaptophysin / Q000276:immunology / Q000378:metabolism; D013869:Thiolester Hydrolases / Q000276:immunology / Q000378:metabolism; D043222:Ubiquitin Thiolesterase
chemical_list: D016708:Synaptophysin; D012701:Serotonin; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase