title: An automated liquid chromatography/mass spectrometry system coupled on-line with microdialysis for the in vivo analysis of contrast agents.
abstract: An automated high-performance liquid chromatography (HPLC)/mass spectrometry instrument coupled on-line with a microdialysis probe is described for the analysis of contrast agents in biological fluids. This system is used for pharmacokinetic and structure elucidation studies of contrast agents used in X-ray and magnetic resonance imaging investigations. Additionally an LC/MS system for the direct analysis of urine, that obviates the need for conventional sample clean-up, is described.
authors.affiliation: Nycomed Innovation AB, Malmö, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Michelsen
authors.forename: G
authors.initials: G
authors.lastname: Pettersson
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000032:analysis* / Q000493:pharmacokinetics; D008099:Liver / Q000737:chemistry; D008297:Male; D013058:Mass Spectrometry; D017551:Microdialysis; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003287:Contrast Media