[The effect of the yeast polysaccharide rodexman on the function of the immunocompetent cells in patients with pulmonary tuberculosis].
In vitro experiments established immunomodulatory effect of yeast-originated polysaccharide rodexamen. Functional state of lymphocytes and monocytes of peripheral blood before and after the contact with the drug was studied in 50 patients with pulmonary tuberculosis and in 20 healthy subjects. Effect of rodexamen on lymphocytes and monocytes was assessed by rosette-forming abilities and phagocytic activity respectively. The results demonstrated dependence of immunocorrective effect on the initial level of cell's functional activity and quantity of the drug.
Podgaĭnaia
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D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D012248:Rhodotorula; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C048935:rodexman
Vliianie drozhzhevogo polisakharida rodéksmana na funktsional'noe sostoianie immunokompetentnykh kletok u bol'nykh tuberkulezom legkikh.