Genotypic analysis of Epstein-Barr virus associated with nasopharyngeal carcinoma of Japanese patients.
Types and certain genetic markers were studied for Epstein-Barr virus present in 10 specimens of nasopharyngeal carcinoma (NPC) from Japanese patients. The type 1 virus was predominant in our NPC specimens, as in the general Japanese population, and the type 2 virus was found only in one NPC specimen. The type C variant, which lacks the BamHI site between the BamHI-W1* and -I1* regions, appeared to be common among Japanese strains as in those in Southern China. The type f variant which has an extra BamHI site in the BamHI-F region and has been shown to be strongly associated with NPC in Southern China was found in only one NPC specimen. This virus strain was also the only type 2 virus among our specimens. The present study, therefore, does not show any specific association of the type f variant with NPC in Japan.
Tamura
S
S
Shionogi Institute for Medical Science, Osaka.
Kunimoto
M
M
Tabata
T
T
Yoshie
O
O
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D015139:Blotting, Southern; D002277:Carcinoma / Q000382:microbiology*; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D004277:DNA, Single-Stranded / Q000737:chemistry; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000145:classification / Q000235:genetics*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007564:Japan; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009303:Nasopharyngeal Neoplasms / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014412:Tumor Virus Infections / Q000382:microbiology*
D000914:Antibodies, Viral; D004277:DNA, Single-Stranded; D004279:DNA, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G