Staurosporine derivatives reverse multidrug resistance without correlation with their protein kinase inhibitory activities.
Wakusawa
S
S
Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Inoko
K
K
Miyamoto
K
K
Kajita
S
S
Hasegawa
T
T
Harimaya
K
K
Koyama
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D004351:Drug Resistance; D007941:Leukemia P388 / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors; D019311:Staurosporine; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000470:Alkaloids; D008562:Membrane Glycoproteins; D047428:Protein Kinase Inhibitors; D011493:Protein Kinase C; D019311:Staurosporine