title: GPI anchor-hydrolyzing phospholipases.
abstract: Glycosylphosphatidylinositol(GPI) anchor-hydrolyzing phospholipases include C- and D-type phospholipases and have been described in a number of organisms including bacteria, protozoan parasites, plants, and mammals. Although these phospholipases efficiently cleave GPI structures in vitro, the physiological role of GPI hydrolysis by anchor-specific phospholipases is still unclear. In order to permit comparison of the known GPI anchor-hydrolyzing phospholipases, we studied the kinetic parameters of these enzymes and provide an overview of the currently available information.
authors.affiliation: Institute of Biochemistry and Molecular Biology, University of Bern, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Brodbeck
authors.forename: P
authors.initials: P
authors.lastname: Bütikofer
mesh_terms: D000818:Animals; D017261:Glycosylphosphatidylinositols / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D010739:Phospholipase D / Q000378:metabolism / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism / Q000502:physiology*
chemical_list: D017261:Glycosylphosphatidylinositols; D010738:Type C Phospholipases; D010739:Phospholipase D