Differential effects of the D2 receptor agonist quinelorane on the secretion of prolactin and alpha-melanocyte-stimulating hormone.
The purpose of the present study was to determine the effects of quinelorane, a selective D2 receptor agonist, on concentrations of prolactin and alpha-melanocyte-stimulating hormone (alpha-MSH) in plasma of male rats. Quinelorane decreased plasma concentrations of prolactin but not of alpha-MSH, whereas, the D2 receptor antagonist raclopride increased plasma concentrations of both hormones. Quinelorane reversed the effects of raclopride on circulating levels of prolactin, but not alpha-MSH. The results of this study suggest that secretion of hormones from melanotrophs and lactotrophs is regulated by different subtypes of D2 receptors.
Eaton
M J
MJ
Department of Pharmacology and Toxicology Michigan State University, East Lansing 48824.
Moore
K E
KE
Lookingland
K J
KJ
D000704:Analysis of Variance; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D008297:Male; D011388:Prolactin / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*; D020891:Raclopride; D011863:Radioimmunoassay; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D012457:Salicylamides / Q000494:pharmacology; D000521:alpha-MSH / Q000097:blood / Q000187:drug effects* / Q000378:metabolism
D015259:Dopamine Agents; D065127:Dopamine D2 Receptor Antagonists; D011804:Quinolines; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D020891:Raclopride; D000521:alpha-MSH; D011388:Prolactin; C047726:quinelorane