[Effect of fruit and vegetable juices on the changes in the production of carcinogenic N-nitroso compounds in human gastric juice].
The study was made of the effect of apple, grapefruit, orange and beet juices on in vitro formation of N-nitrosodimethylamine (NDMA) from sodium nitrite and amidopirin in human gastric juice (GJ). Experimental samples of GJ from outpatients attending the outpatient department of the AMS Cancer Research Center were used. The patients had various forms of gastritis and gastric cancer. It was found that fruit and beet juices may inhibit or enhance NDMA formation depending on the GJ composition, pH in particular. In acid medium (pH-1.3-3.4) there was a trend to inhibition of NDMA synthesis, while in neutral and alkaline (pH = 7.4-8.5) medium NDMA synthesis is activated. Practical implications of the findings are discussed.
Ilńitskiĭ
A P
AP
Iurchenko
V A
VA
D001628:Beverages; D002957:Citrus; D003470:Culture Media; D004128:Dimethylnitrosamine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005638:Fruit; D005750:Gastric Juice / Q000378:metabolism*; D005756:Gastritis / Q000178:diet therapy / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013274:Stomach Neoplasms / Q000178:diet therapy / Q000378:metabolism*; D014675:Vegetables
D003470:Culture Media; D004128:Dimethylnitrosamine
Modifitsiruiushchee vliianie fruktovykh i ovoshchnykh sokov na obrazovanie kantserogennykh N-nitrozosoedineniĭ v zheludochnom soke cheloveka.