title: Introduction: treatment of malignancies poorly responsive to currently available antineoplastic therapy.
abstract: The decision whether to treat patients with malignancies that are poorly responsive to antineoplastic agents must be based on a number of important considerations, including the patients' performance status, co-morbid medical conditions, and the anticipated adverse effects of therapy. In appropriate patients, participation in experimental trials should be encouraged. In such circumstances, patients and their families must be given a realistic assessment of the limited or unknown benefits of treatment.
authors.affiliation: Cleveland Clinic Cancer Center, OH 44195.
authors.forename: M
authors.initials: M
authors.lastname: Markman
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D016879:Salvage Therapy; D017211:Treatment Failure
chemical_list: D000970:Antineoplastic Agents