title: An evaluation of bone density and turnover in premenopausal women with type 1 diabetes mellitus.
abstract: Measurement of bone density and turnover was assessed in 20 premenopausal females with Type 1 diabetes mellitus and 27 age-sex-matched controls. Measurement was made of spinal (L2-4) and neck of femur bone density by dual-energy X-ray absorptiometry. L2-4 density was significantly higher in the diabetic patients compared with controls (1.224 +/- 0.021 g cm-2 vs. 1.161 +/- 0.020 g cm-2: p = 0.016). No significant difference was noted between the groups in neck of femur density. Measurement of bone formation was assessed by serum alkaline phosphatase and bone resorption by fasting urinary hydroxyproline/creatinine ratio. Alkaline phosphatase was significantly higher in the diabetic patients (185 +/- 16 Ul-1 vs 135 +/- 10 Ul-1: p < 0.01) as was hydroxyproline/creatinine ratio (0.028 +/- 0.003 vs 0.017 +/- 0.002: p = 0.002). No significant correlation was found between L2-4 density and glycated haemoglobin, duration of diabetes or daily dose of insulin taken. These data suggest that osteopenia is not associated with Type 1 diabetes mellitus; however these patients do have evidence of increased bone turnover and may therefore be at risk of osteoporosis in later life, particularly after the menopause.
authors.affiliation: University Department of Medicine, Glasgow Royal Infirmary, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Gallacher
authors.forename: J A
authors.initials: JA
authors.lastname: Fenner
authors.forename: B M
authors.initials: BM
authors.lastname: Fisher
authors.forename: J D
authors.initials: JD
authors.lastname: Quin
authors.forename: W D
authors.initials: WD
authors.lastname: Fraser
authors.forename: F C
authors.initials: FC
authors.lastname: Logue
authors.forename: R A
authors.initials: RA
authors.lastname: Cowan
authors.forename: I T
authors.initials: IT
authors.lastname: Boyle
authors.forename: A C
authors.initials: AC
authors.lastname: MacCuish
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood / Q000652:urine; D000242:Cyclic AMP / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008593:Menopause; D010281:Parathyroid Hormone / Q000097:blood; D011877:Radionuclide Imaging; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D003404:Creatinine; D000242:Cyclic AMP; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium