title: The probe BMS1271 identifies a new polymorphic locus (D3S1207) and maps to 3p26-pter.
abstract: We report here the characterization of a new polymorphic locus (D3S1207), shown by fluorescence in situ hybridization to map to 3p26-pter. The distal region of chromosome 3 has been implicated in both von Hippel-Lindau and 3p deletion syndrome, lung, uterine, breast, testicular, and ovarian cancers, renal cell and nasopharyngeal carcinomas, mesotheliomas, and various haematological malignancies, yet relatively few polymorphic marker probes are well mapped within this region. The identification of this new probe will therefore be particularly useful for the study of these diseases.
authors.affiliation: MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Heppell-Parton
authors.forename: M C
authors.initials: MC
authors.lastname: Daly
authors.forename: H A
authors.initials: HA
authors.lastname: Drabkin
authors.forename: P H
authors.initials: PH
authors.lastname: Rabbitts
mesh_terms: D015139:Blotting, Southern; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D015342:DNA Probes; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D006623:von Hippel-Lindau Disease / Q000235:genetics*
chemical_list: D015342:DNA Probes