Tetracycline resistance determinants in Mycobacterium and Streptomyces species.
Two of seven tetracycline-resistant (Tcr) Mycobacterium fortuitum group isolates and six Tcr clinical Streptomyces isolates carried gram-positive Tcr determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the acquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species.
Pang
Y
Y
Department of Pathobiology, University of Washington, Seattle 98195.
Brown
B A
BA
Steingrube
V A
VA
Wallace
R J
RJ
Roberts
M C
MC
D001483:Base Sequence; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000187:drug effects / Q000235:genetics*; D016133:Polymerase Chain Reaction; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics*; D013753:Tetracycline Resistance / Q000235:genetics*