title: Intrafamilial clustering of hepatitis A.
abstract: The intrafamilial clustering of hepatitis A virus infections (HAV) in families with an index case of sporadic hepatitis A was studied. Four hundred and three family members (84.3%) of 113 children with acute hepatitis A admitted to the Paediatric Department of the West Attica Hospital were included in the study. Epidemiological data and serum samples were collected within 1 week after the patient's admittance to the hospital. Enzyme-immunoassays were used to detect recent or past HAV infections. The attack rate of HAV infections in susceptible family members was found to be similar in susceptible fathers (16.6%, 1/6), mothers (23.5%, 4/17) and siblings (18.1%, 37/204). The infected family members belonged to 22 families. The attack rate was found to be higher in families with a lower immunity level, while the social class was not found to play an important role. The administration of ISG prevented further spread of hepatitis A among those susceptible. Our data suggest that immunoglobulin for HAV prevention should be given not only to children but also to parents and other adult family members in areas with a low prevalence of anti-HAV among adults.
authors.affiliation: Athens School of Public Health, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Roumeliotou
authors.forename: A
authors.initials: A
authors.lastname: Papachristopoulos
authors.forename: D
authors.initials: D
authors.lastname: Alexiou
authors.forename: V
authors.initials: V
authors.lastname: Papaevangelou
authors.forename: G
authors.initials: G
authors.lastname: Stergiou
authors.forename: G
authors.initials: G
authors.lastname: Papaevangelou
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D006506:Hepatitis A / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D015995:Prevalence; D012008:Recurrence; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D013029:Space-Time Clustering