title: Haemodynamic evaluation of retrograde versus anterograde delivery of cardioplegic solution in aortic valve replacement.
abstract: A total of 44 patients undergoing isolated aortic valve replacement received either anterograde (20 patients) or retrograde (24 patients), cold St Thomas's Hospital cardioplegia. The patients were similar with respect to age, sex, left ventricular ejection fraction, left ventricular-aortic pressure gradient, cross-clamping time and mean dose of cardioplegia. After surgery, there were no differences in enzyme release, low cardiac output syndrome, rhythm disturbances or clinical outcome between the two groups. Analysis of the postoperative haemodynamic data, however, suggests better preservation of left ventricular contractility with retrograde delivery of cardioplegic solution.
authors.affiliation: Department of Thoracic and Cardiac Surgery, University Hospital Nijmegen St Radboud, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Noyez
authors.forename: J A
authors.initials: JA
authors.lastname: van Son
authors.forename: T
authors.initials: T
authors.lastname: van der Werf
authors.forename: W N
authors.initials: WN
authors.lastname: van Asten
authors.forename: L K
authors.initials: LK
authors.lastname: Lacquet
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000503:physiopathology / Q000601:surgery*; D001639:Bicarbonates / Q000008:administration & dosage / Q000009:adverse effects; D002122:Calcium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D002314:Cardioplegic Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006349:Heart Valve Diseases / Q000503:physiopathology / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology; D011189:Potassium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D001639:Bicarbonates; D002314:Cardioplegic Solutions; C041711:St. Thomas' Hospital cardioplegic solution; D012965:Sodium Chloride; D011189:Potassium Chloride; D008274:Magnesium; D002122:Calcium Chloride