title: A study on the hemostatic effect of sodium alginate on uterocervical hemorrhage.
abstract: We examined a sodium alginate preparation (Alto) to determine its hemostatic effect, in comparison with other topical drugs, on hemorrhages in the uterocervical area. A total of 149 patients with hemorrhage from cervical erosion or after-treatment bleeding of the cervix uteri were subjects in this trial, and 84 (79%) of 106 patients treated with this preparation experienced a hemostatic effect. A significant positive correlation (p < 0.001) was noted between the degree of tissue adhesiveness and the hemostatic effect in all the drugs tested. As for the tissue adhesiveness, Alto was significantly more favorable (p < 0.001) than both Thrombin and Francetin T powder. Because Alto was softened by tissue moisture, its topical adhesiveness could be increased, which suggested that Alto was superior in hemostasis.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishiya
authors.forename: H
authors.initials: H
authors.lastname: Hareyama
authors.forename: S
authors.initials: S
authors.lastname: Makinoda
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000464:Alginates / Q000627:therapeutic use*; D002648:Child; D005260:Female; D020723:Glucuronic Acid; D006490:Hemostatics / Q000627:therapeutic use*; D006603:Hexuronic Acids; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000188:drug therapy*
chemical_list: D000464:Alginates; D006490:Hemostatics; D006603:Hexuronic Acids; D020723:Glucuronic Acid