title: In-vitro synthesis of antibodies to Toxoplasma gondii by lymphocytes from HIV-1-infected patients.
abstract: Toxoplasma-specific in-vitro antibody production by peripheral blood lymphocytes (PBL) was investigated in 124 adults infected with human immunodeficiency virus (HIV-1). PBL from 20 of 21 patients with cerebral toxoplasmosis showed spontaneous in-vitro secretion of antibodies to Toxoplasma gondii antigens. Among 103 HIV-1-infected patients without signs or symptoms of toxoplasmosis, PBL from 19 produced toxoplasma-specific antibodies in vitro; 5 of these patients, who discontinued prophylaxis for toxoplasmic encephalitis, showed in-vitro antibody production 3-15 months before the diagnosis of toxoplasmic encephalitis. In-vitro production of toxoplasma-specific antibodies could improve the diagnosis of toxoplasmic encephalitis in HIV-1-infected patients.
authors.affiliation: Department of Immunology, INSERM unit 249, Institut de Biologie, Montpellier, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Vendrell
authors.forename: J
authors.initials: J
authors.lastname: Reynes
authors.forename: M F
authors.initials: MF
authors.lastname: Huguet
authors.forename: J
authors.initials: J
authors.lastname: Ngou
authors.forename: C
authors.initials: C
authors.lastname: Michard
authors.forename: N
authors.initials: N
authors.lastname: Atoui
authors.forename: F
authors.initials: F
authors.lastname: Pratlong
authors.forename: M
authors.initials: M
authors.lastname: Segondy
authors.forename: A
authors.initials: A
authors.lastname: Serre
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000276:immunology; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis*; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D015497:HIV-1; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014122:Toxoplasma / Q000276:immunology*; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan