title: Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum.
abstract: Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.
authors.affiliation: Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian.
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: R
authors.initials: R
authors.lastname: Ma
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000633:toxicity; D004365:Drugs, Chinese Herbal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D012503:Saponins / Q000494:pharmacology* / Q000633:toxicity; D014315:Triterpenes / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C051084:tubeimoside I