Inhibition of delta aminolevulinic acid dehydratase activity by aluminum.
1. Studies were performed regarding the effects of aluminum chloride and aluminum nitrate in concentrations of 5 mg/kg of body weight on the delta aminolevulinic acid dehydratase activity, iron level and hematological parameters. Wistar rats were exposed to these pollutants for 10, 20, 40 and 80 days. 2. The results demonstrated that aluminum chloride was more toxic than aluminum nitrate and both treatments brought about significant changes in these parameters in Wistar rats bone marrow. 3. The toxic effects of aluminum chloride and aluminum nitrate are manifested by a significant decrease of delta aminolevulinic acid dehydratase activity in the bone marrow of rats. 4. The iron level in bone marrow with aluminum chloride and aluminum nitrate gradually dropped after 10, 20, 40 and 80 days of intoxication. 5. In the peripheral blood a significant decrease in the erythrocyte count, hemoglobin level, hematocrit value and an increase in mean corpuscular hemoglobin (MCH) were also found in experimental animals.
Zaman
K
K
Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia.
Zaman
W
W
Dabrowski
Z
Z
Miszta
H
H
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008297:Male; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar
D000535:Aluminum; D007501:Iron; D000623:Porphobilinogen Synthase