title: Effect of acute edema on left ventricular function and coronary vascular resistance in the isolated rat heart.
abstract: The impact of acute myocardial edema on coronary flow and left ventricular performance was studied in isolated isovolumic rat hearts. After 15 min of aortic perfusion with Krebs-Henseleit buffer, hearts (10/group) were either removed for determination of water content or perfused for another 90 min. Three groups were perfused at a constant pressure of 60, 100, or 140 mmHg, and two groups were perfused at 60 or 140 mmHg with adenosine added. Compared with the 15-min group, there was a significant increase in water content in all groups except the 60-mmHg group (P < 0.005). There was a direct linear relationship between increases in coronary vascular resistance over time and water content (P < 0.0001). A decrease in developed pressure and peak +dP/dt was observed only in those groups that accumulated water. An inverse linear relationship was found between changes in developed pressure and water content (P = 0.0001). Water content had no effect on end-diastolic pressure below 5 ml/g; above 5 ml/g, a direct linear relationship was evident (P = 0.009). The results suggest that myocardial edema increases vascular resistance and decreases systolic performance. End-diastolic pressure is less influenced by edema than either systolic or coronary vascular function.
authors.affiliation: Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153.
authors.forename: A
authors.initials: A
authors.lastname: Rubboli
authors.forename: P A
authors.initials: PA
authors.lastname: Sobotka
authors.forename: D E
authors.initials: DE
authors.lastname: Euler
mesh_terms: D000208:Acute Disease; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001834:Body Water / Q000378:metabolism; D003326:Coronary Circulation / Q000187:drug effects; D003971:Diastole; D004489:Edema, Cardiac / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D013997:Time Factors; D014655:Vascular Resistance; D016277:Ventricular Function, Left
chemical_list: D000241:Adenosine