title: Initial clinical experience in MR imaging of the brain with a fast fluid-attenuated inversion-recovery pulse sequence.
abstract: OBJECTIVE
  To evaluate fast fluid-attenuated inversion-recovery (FLAIR) technique for imaging brain abnormalities.
  
  
  METHODS
  A fast FLAIR sequence was developed that provided 36 5-mm contiguous sections in 5 minutes 8 seconds. Resulting images were compared with dual-echo T2-weighted spin-echo images of 41 consecutive patients with brain abnormalities.
  
  
  RESULTS
  Contrast and contrast-to-noise ratios (C/Ns) (for contrast between the lesion and background and between the lesion and cerebrospinal fluid) for fast FLAIR exceeded the corresponding values for T2-weighted spin-echo images for all but the second-echo lesion-to-background C/N. Fast FLAIR provided equivalent or greater overall lesion conspicuity and enabled greater lesion detection in 98% and 100%, respectively, of the evaluations. Fast FLAIR images more often had image artifact, but this did not interfere with image interpretation in a significantly (P < or = .05) greater number of evaluations.
  
  
  CONCLUSIONS
  Fast FLAIR provides images that are superior to proton-density- and T2-weighted images for many image quality criteria.
authors.affiliation: Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905.
authors.forename: J N
authors.initials: JN
authors.lastname: Rydberg
authors.forename: C A
authors.initials: CA
authors.lastname: Hammond
authors.forename: R C
authors.initials: RC
authors.lastname: Grimm
authors.forename: B J
authors.initials: BJ
authors.lastname: Erickson
authors.forename: C R
authors.initials: CR
authors.lastname: Jack
authors.forename: J
authors.initials: J
authors.lastname: Huston
authors.forename: S J
authors.initials: SJ
authors.lastname: Riederer
mesh_terms: D016477:Artifacts; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D013997:Time Factors