Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia.
We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.
Crossen
P E
PE
Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
Morrison
M J
MJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016009:Chi-Square Distribution; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes / Q000235:genetics*
C024408:endodeoxyribonuclease SacI; D015252:Deoxyribonucleases, Type II Site-Specific