title: The dopamine D3 receptor gene: no association with bipolar affective disorder.
abstract: Bipolar affective disorder and schizophrenia share many clinical and genetic characteristics, and are thought by some to be different expressions of the same underlying disorder. A recent study showed an excess of homozygosity at a BalI polymorphism in the dopamine D3 receptor gene in schizophrenic patients compared with controls, from two independent centres. We have found no evidence of such an excess in a comparable sample of patients with bipolar affective disorder compared with matched controls. If these findings are confirmed then at least one genetic distinction between these two disorders will have been ascertained and doubt cast upon theories of a common genetic aetiology.
authors.affiliation: Genetics Section, Institute of Psychiatry, De Crespigny Park, London.
authors.forename: S
authors.initials: S
authors.lastname: Shaikh
authors.forename: D
authors.initials: D
authors.lastname: Ball
authors.forename: N
authors.initials: N
authors.lastname: Craddock
authors.forename: D
authors.initials: D
authors.lastname: Castle
authors.forename: N
authors.initials: N
authors.lastname: Hunt
authors.forename: R
authors.initials: R
authors.lastname: Mant
authors.forename: M
authors.initials: M
authors.lastname: Owen
authors.forename: D
authors.initials: D
authors.lastname: Collier
authors.forename: M
authors.initials: M
authors.lastname: Gill
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics
chemical_list: C493593:DRD3 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3