[Significance of short-term cytotoxicity tests for hygienic assessment of industrial aerosols].
The evaluation of low-soluble particles toxicity for human phagocytes (primarily, for macrophages) was proved to have advantages in predicting their effects on the human body and in rapid toxico-hygienic regulation. The preference is given to tests "in vitro". If comparative toxicities of substances in group are discordant according to different "in vitro" tests the decision must be made after the "in vivo" evaluation of cytotoxicity: in 24 hours after the intratracheal administration of small doses of these low-soluble particles the bronchoalveolar lavage is examined cytologically. Reliable neutrophilia in lavage is of great value.
Katsnelśon
B A
BA
Privalova
L I
LI
Sharapova
N E
NE
Kislitsina
N S
NS
D000280:Administration, Inhalation; D000336:Aerosols / Q000009:adverse effects*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D007221:Industry; D015227:Lipid Peroxidation / Q000187:drug effects; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D009503:Neutropenia / Q000378:metabolism; D013997:Time Factors
D000336:Aerosols; D015386:Hazardous Substances
O znachenii sistemhy kratkovremennykh testov na tsitotoksichnost dlia gigienicheskoĭ kharakteristiki promyshlennykh aérozoleĭ.