Increasing complexity of the dystrophin-associated protein complex.
Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease caused by lack of the protein dystrophin. The exact function of dystrophin remains to be determined. However, analysis of its interaction with a large oligomeric protein complex at the sarcolemma and the identification of a structurally related protein, utrophin, is leading to the characterization of candidate genes for other neuromuscular disorders.
Tinsley
J M
JM
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
Blake
D J
DJ
Zuellig
R A
RA
Davies
K E
KE
D000818:Animals; D002135:Calcium-Binding Proteins; D002874:Chromosome Mapping; D003598:Cytoskeletal Proteins / Q000502:physiology*; D049030:Dystroglycans; D016189:Dystrophin / Q000502:physiology*; D005796:Genes; D006801:Humans; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D009124:Muscle Proteins / Q000502:physiology*; D009132:Muscles / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology; D049411:Utrophin
D002135:Calcium-Binding Proteins; D003598:Cytoskeletal Proteins; C483081:DAG1 protein, human; D016189:Dystrophin; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D049411:Utrophin; C091825:syntrophin alpha1; D049030:Dystroglycans