Linkage analysis on complex pedigrees by simulation.
A Markovian scheme for simulating the genotypes of individuals in a pedigree subject to constraints imposed by observed phenotypes is used to estimate the logarithm of a likelihood ratio in linkage analysis. The method is illustrated on a fictitious pedigree by comparison with exactly calculated results.
Thomas
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School of Mathematical Sciences, University of Bath, UK.
D000818:Animals; D003198:Computer Simulation; D008040:Genetic Linkage; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability