The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. V. Minor metabolites.
The isolation and structure determination of 3H and 13C NMR and MS of 24 novel squalestatins from cultures of Phoma sp. C2932 is described.
Blows
W M
WM
Department of Natural Products Discovery, Glaxo Research and Development Ltd., Greenford, Middlesex, United Kingdom.
Foster
G
G
Lane
S J
SJ
Noble
D
D
Piercey
J E
JE
Sidebottom
P J
PJ
Webb
G
G
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D014233:Tricarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*
D000935:Antifungal Agents; D001643:Bridged Bicyclo Compounds; D014233:Tricarboxylic Acids; D013186:Farnesyl-Diphosphate Farnesyltransferase