The antioxidant system of the organism. Theoretical basis and practical consequences.
On the basis of the literature and our own investigations, the antioxidant mechanisms and substances of the human organism are described and classified as compartmentalization, detoxification, repair and utilization. The existence and the structure of an antioxidant system, which serves as support of the antioxidant homeostasis, are hypothesized. A parameter for characterizing the state of the antioxidant system and for detecting its changes under pathological conditions--the integral antioxidant capacity of blood plasma--and a method for its determination are suggested.
Lewin
G
G
Research Laboratory for Antioxidant Therapy, Medical Faculty (Charité) of Humboldt University, Berlin, Germany.
Popov
I
I
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005609:Free Radicals; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D010084:Oxidation-Reduction; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D013481:Superoxides