title: 3-dimensional functional imaging of human brain using echo-shifted FLASH MRI.
abstract: A 3-dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo-shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.
authors.affiliation: Laboratory of Diagnostic Radiology Research, OIR, NIH, Bethesda, Maryland 20892.
authors.forename: J H
authors.initials: JH
authors.lastname: Duyn
authors.forename: V S
authors.initials: VS
authors.lastname: Mattay
authors.forename: R H
authors.initials: RH
authors.lastname: Sexton
authors.forename: G S
authors.initials: GS
authors.lastname: Sobering
authors.forename: F A
authors.initials: FA
authors.lastname: Barrios
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: J A
authors.initials: JA
authors.lastname: Frank
authors.forename: D R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: C T
authors.initials: CT
authors.lastname: Moonen
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*