[Rate of in vitro degradation of vecuronium in plasma of patients with renal failure and pregnancy].
The half-life of vecuronium in plasma by spontaneous desacetylation is about 120 minutes. We have to consider this degradation for examining the cause of prolonged duration of action of vecuronium. Therefore the rate of in vitro plasma spontaneous desacetylation of vecuronium bromide was measured in healthy women (n = 10), patients with renal failure (n = 10) and pregnant women (n = 10). There were no significant differences between three groups. It was concluded that the rate of spontaneous desacetylation was not responsible for the cause of prolonged neuromuscular blockade of vecuronium in patients with renal failure and pregnancy.
Kumagai
K
K
Department of Anesthesiology, Kanazawa Medical University, Ishikawa.
Hatashima
S
S
Mori
H
H
D004355:Drug Stability; D005260:Female; D006207:Half-Life; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy / Q000097:blood*; D051437:Renal Insufficiency / Q000097:blood*; D014673:Vecuronium Bromide / Q000097:blood*
D014673:Vecuronium Bromide