Experimental and clinical observations on the role of endogenous and on the effect of exogenous prostacyclin in gastric mucosa. A personal view.
In the gastric mucosa the exogenously administered prostacyclin seems to have a polyphasic effect which contains the following consecutive steps: 1. Binding to the cell surface; 2. Effect on the intracellular "second messenger system", i.e. on the cyclic nucleotide (cAMP, cGMP) turnover; 3. Activation of the calmodulin-system; 4. cAMP-dependent protein kinase activation; Nucleic acid,--DNA,RNA,--changes; 6. Influence on protein synthesis and finally; 7. New cell formation. On the other hand, the endogenous (mucosal) prostacyclin exerts a natural protection against different damaging noxae.
Balint
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Department of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000818:Animals; D002147:Calmodulin / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D011464:Epoprostenol / Q000494:pharmacology* / Q000502:physiology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism; D051381:Rats
D002147:Calmodulin; D009696:Nucleic Acids; D011464:Epoprostenol; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D006152:Cyclic GMP