Influence of the sterilization process on alginate dispersions.
The influence of different sterilization procedures on alginate dispersions was studied by measuring viscosity and molecular weight changes. Autoclaving caused a 64% decrease in viscosity. Heating at a low temperature over several cycles was less efficient in sterilizing alginates and there was a progressive breakdown of the alginate chain over the succeeding cycles. Heating during ethylene oxide sterilization also resulted in reduced viscosity and breakdown. Membrane filtration yielded a sterile product with no significant reduction in viscosity or mol. wt.
Vandenbossche
G M
GM
Laboratory of Pharmaceutical Technology, University of Ghent, Belgium.
Remon
J P
JP
D000464:Alginates / Q000737:chemistry*; D001709:Biotechnology / Q000379:methods; D002850:Chromatography, Gel; D005027:Ethylene Oxide; D008970:Molecular Weight; D013242:Sterilization / Q000379:methods; D014783:Viscosity
D000464:Alginates; D005027:Ethylene Oxide