Hsp70RY: further characterization of a novel member of the hsp70 protein family.
Hsp70RY was identified as a member of the hsp70 protein family on the basis of cDNA sequence homology (Fathallah, et. al. (1993) J. Immunol. 151, 810-813). We have shown that mRNA encoding hsp70RY is expressed in a variety of human cell lines and that mRNA expression remains unchanged in human promyelocytic HL-60 cells induced to differentiate with phorbol 12-myristate 13-acetate (PMA). We have also shown that the predicted amino acid sequence of hsp70RY diverges significantly from the other human hsp70 proteins and that it contains a unique glutamate-rich region near its carboxy-terminus. Finally, we have demonstrated the existence of a murine homolog of hsp70RY.
Dyer
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KD
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Lavigne
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Rosenberg
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D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D015152:Blotting, Northern; D015139:Blotting, Southern; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002461:Cell Line, Transformed; D015870:Gene Expression; D014644:Genetic Variation; D005971:Glutamates / Q000032:analysis; D050957:HSP110 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute; D051379:Mice; D012333:RNA, Messenger / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D005971:Glutamates; D050957:HSP110 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C121993:HSPA4 protein, human; D006360:Heat-Shock Proteins; D012333:RNA, Messenger; D013755:Tetradecanoylphorbol Acetate