CD3, CD8 double-positive cells from HIV-1-infected chimpanzees show group-specific inhibition of HIV-1 replication.
The CD8-positive (CD8+) lymphocyte population in the chimpanzee is composed of two major subsets, a CD3-positive, CD8-positive (CD3+CD8+) and a CD3-negative, CD8-positive (CD3-CD8+) population. The aim of this study was to delineate the function of CD3+CD8+ T cells with respect to inhibition of HIV-1 replication. It could be shown that this cell population had the capacity to control the growth of HIV-1 in exogenously infected CD4-positive (CD4+) lymphocytes. This effect was observed only with cells from HIV-1-infected chimpanzees, was operative only in an autologous and not in a homologous situation, and was not due to cytotoxicity. CD3+CD8+ lymphocyte-mediated inhibition of HIV-1 replication was group-specific in that CD3+CD8+ cells of HIV-1 (IIIB)-infected chimpanzees were capable of inhibiting replication of HIV-1 strains IIIB, MN, and RF. The effect observed was operational during the early stages of HIV-1 replication only; the effector cells had to be added to CD4+ cells within 3 days after HIV-1 infection in order to suppress growth of the virus. The presence of CD3+CD8+ lymphocytes with anti-HIV-1 activity in the circulation of HIV-1-infected chimpanzees might contribute to the lack of progression toward AIDS observed in this species.
Husch
B
B
Department of Immunological Research, Immuno AG, Vienna, Austria.
Eibl
M M
MM
Mannhalter
J W
JW
D000818:Animals; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D016827:CD8 Antigens; D015658:HIV Infections / Q000276:immunology* / Q000382:microbiology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology; D008213:Lymphocyte Activation; D002679:Pan troglodytes; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014779:Virus Replication / Q000276:immunology
D017252:CD3 Complex; D016827:CD8 Antigens