Does HCG treatment induce inflammation-like changes in undescended testes in boys?
Twenty-two cryptorchid boys previously unsuccessfully treated with human chorionic gonadotropin (hCG) were operated. Testicular biopsies were taken and a routine orchidopexy was performed in each case. As controls eight cryptorchid boys without prior hormonal treatment were operated in the same way. A mild inflammation-like reaction was found in the cryptorchid testes in the period immediately following the last hCG injection. However, in testes studied 6 to 12 months after the last hCG injection there were no apparent signs of hCG-induced tubular damage.
Hjertkvist
M
M
Department of Surgery, University of Umeå, Sweden.
Läckgren
G
G
Plöen
L
L
Bergh
A
A
D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003456:Cryptorchidism / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004912:Erythrocytes / Q000187:drug effects; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D007249:Inflammation; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D013548:Sweden; D013997:Time Factors; D017211:Treatment Failure
D006063:Chorionic Gonadotropin