Differential effects of the (+)- and (-)-gossypol enantiomers upon Entamoeba histolytica axenic cultures.
The in-vitro anti-amoebic effects of (+/-)-, (+)-, (-)-gossypol and emetine were tested against axenic trophozoites from five Entamoeba histolytica strains. The (-)-isomer was more active than the racemate and the (+)-isomer. These results indicate that the gossypol anti-amoebic activity is mainly due to its content of (-)-gossypol in all strains tested.
González-Garza
M T
MT
Unidad de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Leon.
Matlin
S A
SA
Mata-Cárdenas
B D
BD
Said-Fernández
S
S
D000818:Animals; D004748:Entamoeba histolytica / Q000187:drug effects*; D006072:Gossypol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
D006072:Gossypol