Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules.
Carboni
J M
JM
Department of Experimental Therapeutics, and Antitumor Chemistry, Bristol Myers Squibb Research Institute, Wallingford, Connecticut 06492.
Farina
V
V
Rao
S
S
Hauck
S I
SI
Horwitz
S B
SB
Ringel
I
I
D000230:Adenocarcinoma; D000345:Affinity Labels / Q000138:chemical synthesis*; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002460:Cell Line; D003110:Colonic Neoplasms; D005455:Fluorescent Antibody Technique; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000378:metabolism*; D010777:Photochemistry; D014407:Tumor Cells, Cultured
D000345:Affinity Labels; D017239:Paclitaxel