title: Phospholipid hydroperoxide glutathione peroxidase in the normal human kidney: a possible role in protecting cell membranes.
abstract: Reactive oxygen species have been implicated in the pathogenesis of tissue injury. It is generally accepted that selenium-glutathione peroxidases form an integrated system defending the living organism against oxidative damage. Phospholipid hydroperoxide glutathione peroxidase (PHGPX) is thought to play a prominent role in preventing lipid peroxidation. Indeed, the function of PHGPX is to reduce the lipophilic substrates in membranes. In the present study, we evaluated the expression of PHGPX in normal human kidney by immunohistochemistry. The enzyme in glomeruli is mainly expressed in podocytes and parietal epithelial cells. In addition, PHGPX antigen was detected in tubule epithelial cells. Therefore, these results suggest that renal epithelial cells possess an important antioxidizing activity related to the presence of PHGPX.
authors.affiliation: Department of Nephrology, S. Bortolo Hospital, Vicenza, Italy.
authors.forename: P A
authors.initials: PA
authors.lastname: Conz
authors.forename: P A
authors.initials: PA
authors.lastname: Bevilacqua
authors.forename: G
authors.initials: G
authors.lastname: La Greca
authors.forename: D
authors.initials: D
authors.lastname: Danieli
authors.forename: M P
authors.initials: MP
authors.lastname: Rodighiero
authors.forename: L
authors.initials: L
authors.lastname: Cavarretta
authors.forename: M
authors.initials: M
authors.lastname: Maiorino
authors.forename: A
authors.initials: A
authors.lastname: Roveri
authors.forename: F
authors.initials: F
authors.lastname: Ursini
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000201:enzymology*; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D012016:Reference Values; D014018:Tissue Distribution
chemical_list: D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase