Experimental evaluation of a new composite mesh with the selective property of incorporation to the abdominal wall without adhering to the intestines.
This preliminary study examined the possibility of preventing intestinal adhesions to biomaterials while preserving their incorporation with the abdominal wall. White New Zealand rabbits received intraperitoneal implants of different biomaterials for repair of defects created on the abdominal wall. The following biomaterials were used: polypropylene, polyester, expanded polytetraflueroethylene, polypropylene mesh/polypropylene sheeting (polypropylene mesh covered with polypropylene sheeting on the peritoneal side), polypropylene/silastic, polypropylene/polyglactin, polypropylene/polyglycolic acid, and polypropylene/fibrin. All biomaterials evaluated caused adhesions to the intestines except for polypropylene mesh/polypropylene sheeting and polypropylene mesh/silastic composites. Because adhesion of the intestine to the biomaterial is the first stage of biomaterial-related intestinal fistula, its prevention is logical for the elimination of this complication. Composites with the selective property of adhering to the abdominal wall, yet sparing the viscera, would facilitate thoracic and abdominal wall surgeries, as well as intraperitoneal laparoscopic hernioplasties.
Amid
P K
PK
Department of Surgery Harbor-UCLA.
Shulman
A G
AG
Lichtenstein
I L
IL
Sostrin
S
S
Young
J
J
Hakakha
M
M
D000009:Abdominal Muscles / Q000601:surgery*; D000818:Animals; D001557:Benzenesulfonates; D001672:Biocompatible Materials; D006555:Hernia, Ventral / Q000517:prevention & control; D007412:Intestinal Fistula / Q000517:prevention & control; D007813:Laparotomy / Q000009:adverse effects; D008422:Materials Testing; D011093:Polyethylene Terephthalates; D011098:Polyglactin 910; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D011817:Rabbits; D012826:Silicone Elastomers; D013526:Surgical Mesh; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D000267:Tissue Adhesions / Q000517:prevention & control*; D014945:Wound Healing
D001557:Benzenesulfonates; D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D011126:Polypropylenes; D012826:Silicone Elastomers; C025539:Lavsan; C007287:dexon (fungicide), sodium salt; D011098:Polyglactin 910; D011138:Polytetrafluoroethylene; C089227:celgard