Marine antitumor agents: 14-deoxycrassin and pseudoplexaurol, new cembranoid diterpenes from the Caribbean gorgonian Pseudoplexaura porosa.
Two new cytotoxic antitumor diterpenoids of the cembrane class, named 14-deoxycrassin (3) and pseudoplexaurol (4), have been isolated from the Caribbean gorgonian octocoral Pseudoplexaura porosa. The structure of lactone 3, possessing the infrequently encountered alpha-methylene-delta-lactone ring, has been established from spectral and chemical data and that of alcohol 4 has been established from spectral data.
Rodríguez
A D
AD
Department of Chemistry, University of Puerto Rico, Río Piedras 00931-3346.
Martínez
N
N
D000818:Animals; D000970:Antineoplastic Agents; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy
D000970:Antineoplastic Agents; D004224:Diterpenes; C079901:14-deoxycrassin; C079902:pseudoplexaurol