[Vitamin D: clinical aspects and therapy].
This short review summarizes the metabolism and regulation of vitamin D3 with special emphasis on the regulation of renal 25-hydroxy-vitamin D3 1-alpha-hydroxylase. Vitamin D3 is of documented therapeutic utility in the following entities: Vitamin-D3 deficiency, involutional osteoporosis, glucocorticoid-induced osteoporosis and renal osteodystrophy. A therapeutic benefit of vitamin D3 is not yet established for hematological as well as for other neoplasias and for psoriasis. The introduction of noncalcemic vitamin-D3 analogs may lead to an increased use in these indications and will hopefully improve prevention and treatment of renal osteodystrophy.
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Klinik B für Innere Medizin, Kantonsspital St. Gallen.
D002117:Calcitriol / Q000378:metabolism / Q000494:pharmacology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy; D014807:Vitamin D / Q000378:metabolism* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy*
D014807:Vitamin D; D002117:Calcitriol
Vitamin D: Klinik und Therapie.