Plasma lipoproteins, biliary lipids and bile acid profile differ in various strains of Syrian hamsters Mesocricetus auratus.
1. Plasma and biliary lipids were assessed in four strains of Syrian hamsters [Charles River Lakeview, (CHR), Biobreeder F1B (BIO), Harlan Sprague-Dawley (HAR) and Sasco (SAS)] fed a cholesterol-free diet. 2. Plasma cholesterol differed with SAS > CHR > HAR > BIO. 3. BIO Hamsters had the lowest HDL and highest VLDL + LDL/HDL ratio, but their biliary secretion of bile acids, phospholipids and cholesterol was 50% lower than other hamsters. 4. Chenodeoxycholate was highest in CHR and the cholate:cheno ratio depressed in CHR hamsters. 5. CHR hamsters had the highest lithogenic index and cholesterol-saturated bile.
Trautwein
E A
EA
Foster Biomedical Research Laboratory, Brandeis University, Waltham, MA 02254.
Liang
J
J
Hayes
K C
KC
D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism*; D001835:Body Weight / Q000502:physiology; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D006224:Cricetinae; D004032:Diet; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002635:Chenodeoxycholic Acid; D002784:Cholesterol