Comparison of computerized cystometry/micturition and contractile responses of the diabetic rat bladder.
Computerized data acquisition was used to achieve a comprehensive assessment of micturition and cystometry in rats made diabetic with streptozotocin. Diabetic rats had a greater mean voided volume and a significantly shorter interval between voiding during the light cycle. During volume expulsion, the rate of intraluminal pressure development was greater, but the mean duration of volume expulsion was less in the diabetic bladder. The increased rate of intraluminal pressure development in the diabetic bladder at the time of volume expulsion correlated with the greater tension development in bladder body strips in response to acetylcholine stimulation. The inability of the diabetic bladder body to maintain peak intraluminal pressure may contribute to the development of residual urine, increased bladder volume and increased voiding frequency in the diabetic rat.
Curley
R M
RM
Division of Urology/Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Wagner
C H
CH
Murty
V N
VN
Belis
J A
JA
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002940:Circadian Rhythm; D003558:Cystoscopy; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012815:Signal Processing, Computer-Assisted; D001743:Urinary Bladder / Q000503:physiopathology*; D014554:Urination / Q000502:physiology*
D000109:Acetylcholine