[Cryoglobulins in rheumatoid arthritis: exhaustive detection, immunochemical findings and clinical expression].
Cryoglobulins were measured in 29 patients (24 female, age 53.8 +/- 9.8 years) with rheumatoid arthritis (70% active). The cryoprecipitate was isolated, characterized and quantified. Cryoglobulinemia, always polyclonal or type III, was found in 83% of patients. The most frequent immunochemical isotypes found were IgG and A. Acrocyanosis was found in 50% and Raynaud phenomenon in 32% of patients with cryoglobulinemia. It is concluded that exhaustive detection of cryoglobulinemia in rheumatoid arthritis demonstrated a higher frequency than previously reported an is important for understanding pathogenesis of the disease.
Bekavac
J
J
Unidad de Fisiopatología, Facultad de Medicina, Universidad de Chile (Campus Occidente), Santiago de Chile.
Varas
M A
MA
Ardiles
A
A
Aris
H
H
Parra
M A
MA
Orellana
J
J
Santa Cruz
C
C
Silva
M C
MC
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications; D001797:Blood Protein Electrophoresis; D003449:Cryoglobulinemia / Q000150:complications; D003450:Cryoglobulins / Q000032:analysis*; D005260:Female; D006801:Humans; D007120:Immunochemistry; D008297:Male; D008875:Middle Aged
D003450:Cryoglobulins
Crioglobulinas en artritis reumatoide: detección exhaustiva, hallazgos inmunoquímicos y expresion clínica.