title: Yeast ts secretory mutation rgs1 is suppressed by the SEC4 gene of Saccharomyces cerevisiae.
abstract: Yeast rgs1 cells accumulate secretory vesicles in the cytoplasm and stop the secretion of proteins at the restrictive temperature. The ts mutation rgs1 may be suppressed by several different genes; the S. cerevisiae SEC4 gene, encoding the small G-protein involved in the late secretory stage, is one of them. Synthetic lethality of the double rgs1 sec4 mutant is demonstrated.
authors.affiliation: Department of Molecular Biology, Faculty of Biology, Moscow State University, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Gerassimenko
mesh_terms: D001692:Biological Transport; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005800:Genes, Fungal; D006023:Glycoproteins / Q000502:physiology; D008561:Membrane Fusion; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D013489:Suppression, Genetic; D013696:Temperature; D020691:rab GTP-Binding Proteins
chemical_list: D005656:Fungal Proteins; D006023:Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; D019204:GTP-Binding Proteins; C064320:SEC4 protein, S cerevisiae; D020691:rab GTP-Binding Proteins