Structure-activity relationships of antitumor thiazolo[3,4-a]benzimidazole derivatives.
A series of thiazolo[3,4-a]benzimidazole derivatives were evaluated in vitro as antitumor agents against 60 human tumor cell-lines. The influence on the antitumor activity of the nature and type of substitution on the phenyl ring at C-1 is examined and a preliminary quantitative structure-activity relationships is presented.
Chimirri
A
A
Dipartimento Farmaco-Chimico, Università di Messina.
Grasso
S
S
Montforte
A M
AM
Montforte
P
P
Zappalà
M
M
Carotti
A
A
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D013844:Thiazoles; C080109:1H,3H-thiazolo(3,4-a)benzimidazole