[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Antiepileptic effects of a novel amino acid-containing 1,4-dihydropyridine glutapyrone and sodium valproate during combined therapy on generalized pentylenetetrazol- and focal 4-aminopyridine-induced epileptic activity in rat brain cortex were studied, as were combined effects of glutapyrone and phenobarbital on maximal electroshock in mice. The results of these investigations suggest that combined treatment by glutapyrone and sodium valproate or phenobarbital is reasonable and helps potentiate the effect of each drug, thus significantly reducing their doses, and minimize the risk of side effects of the drugs id used in higher doses in case of long treatment.
Karpova
M N
MN
Pankov
O Iu
OIu
Germane
S K
SK
Klusha
V E
VE
Duburs
G
G
D015761:4-Aminopyridine; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004095:Dihydropyridines / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004597:Electroshock; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000188:drug therapy; D005971:Glutamates / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D010634:Phenobarbital / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D004095:Dihydropyridines; D005971:Glutamates; C086069:glutapyrone; D014635:Valproic Acid; D015761:4-Aminopyridine; D010433:Pentylenetetrazole; D010634:Phenobarbital
Antiépilepticheskie éffekty sochetannogo vozdeĭstviia novogo proizvodnogo 1,4-digidropirina glutapirona s val'proatom natriia i fenobarbitalom.