title: Partial sequence analysis of the hepatitis C viral genome in Singapore patients.
abstract: The distribution of hepatitis C viral (HCV) genotypes in Singapore has not been previously determined. We studied the sera of 40 Singapore patients which were PCR-positive for HCV. The HCV genotypes were determined by direct sequencing of amplified sequences of the 5' non-coding region, after reverse transcription. Of the 40 samples, 35/40 (87.5%) were of HCV type 1, 2/40 (5.0%) were of type 2 and 3/40 (7.5%) were of type 3. The most common HCV genotype in this study was the type 1 genotype. Our results confirm the wide geographical distribution of HCV genotypes.
authors.affiliation: Department of Clinical Research, Singapore General Hospital.
authors.forename: A S
authors.initials: AS
authors.lastname: Lee
authors.forename: K Y
authors.initials: KY
authors.lastname: Ng
authors.forename: M K
authors.initials: MK
authors.lastname: Chee
authors.forename: A
authors.initials: A
authors.lastname: Vathsala
authors.forename: H L
authors.initials: HL
authors.lastname: Choong
authors.forename: H S
authors.initials: HS
authors.lastname: Ng
authors.forename: C J
authors.initials: CJ
authors.lastname: Oon
mesh_terms: D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D006526:Hepatitis C / Q000382:microbiology*; D006801:Humans; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012689:Sequence Homology, Nucleic Acid; D012846:Singapore
chemical_list: D012367:RNA, Viral