A perspective: the role of disordered genetic control of neurogenesis in the pathogenesis of migration disorders.
Morphological features of cerebral cortical dysplasias generally regarded under the umbrella term 'migration disorders' have been reviewed and critically analyzed against current knowledge of gene activity involved in neurogenesis. Although data are plentiful regarding the nature and role of these genes in lower forms, i.e. C. elegans and Drosophila, relatively few human homologs have been identified. Multiple genes are involved in various specific aspects of neurogenesis, i.e. neuroblast proliferation, PCD, migration, etc., and it is postulated that there are parallel gene actions in human neural development. A hypothetical construct of specific gene defects in human neurogenesis accounting for the morphological variations observed in the migration disorders is postulated.
Rorke
L B
LB
Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104-4103.
D000818:Animals; D001927:Brain Diseases / Q000235:genetics / Q000473:pathology*; D017173:Caenorhabditis elegans / Q000235:genetics; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology*; D004330:Drosophila / Q000235:genetics; D006801:Humans; D009474:Neurons / Q000473:pathology*