Synthesis of the metabolites of clentiazem.
The metabolites of clentiazem in the urine or bile of rats and dogs were investigated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present paper, fourteen reference compounds as shown in Charts 1, 2 and 3 were synthesized to identify the structures of the metabolites in procedures fundamentally similar to those employed in the synthesis of the corresponding metabolites of diltiazem.
Inoue
H
H
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Nakamura
S
S
Otsuka
H
H
Gaino
M
M
Harada
T
T
Matsuki
K
K
Takeda
M
M
D000818:Animals; D001711:Biotransformation; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000378:metabolism* / Q000493:pharmacokinetics; D004110:Diltiazem / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
D002121:Calcium Channel Blockers; C056595:clentiazem; D004110:Diltiazem