Altered prolactin response to clomipramine rechallenge in healthy subjects.
The effect of an initial challenge with the serotonin (5-HT) uptake inhibitor clomipramine (CMI) on subsequent rechallenge was studied in healthy men who served as volunteers. Carefully screened volunteers were assigned to one of three conditions: (1) CMI challenge followed 2 weeks later by CMI rechallenge; (2) placebo challenge followed 2 weeks later by CMI challenge; and (3) CMI challenge followed 4 weeks later by CMI rechallenge. We found significant blunting of the prolactin response to CMI rechallenge 2 weeks (Signed Rank = -12, p = 0.05), but not 4 weeks after an initial challenge. Placebo challenge did not effect CMI challenge 2 weeks later. These findings suggest that a single exposure to IV CMI may cause 5-HT receptor changes that are present 2, but not 4 weeks later. The ramifications of this finding with regard to the use of 5-HT challenge paradigms in a test-retest design are discussed.
Gilmore
J H
JH
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599.
Ruegg
R G
RG
Ekstrom
R D
RD
Knight
B
B
Carson
S W
SW
Mason
G A
GA
Golden
R N
RN
D000293:Adolescent; D000328:Adult; D002997:Clomipramine / Q000494:pharmacology*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology
D011985:Receptors, Serotonin; D011388:Prolactin; D002997:Clomipramine