title: No-go activity in the frontal association cortex of human subjects.
abstract: 'No-go potential', specific to the no-go reaction in go/no-go reaction-time hand movement with discrimination between different colour light stimuli, was recorded with electrodes chronically implanted in the prefrontal cortex of monkeys. Similar potentials were widely distributed over frontal-parietal parts of the human scalp on the same no-go reaction. In this report, MEG measurement was made over the scalp of five healthy subjects in order to localize current sources responsible for the scalp potential. We found in- and outflow of magnetic fields over the dorsolateral frontal parts of the head, contra- and ipsilateral to the operant hand. These magnetic fields were most reasonably interpreted to be due to current dipoles localized in the dorsolateral parts of frontal lobes in both contra- and ipsilateral hemispheres, presumably in the prefrontal-premotor areas. No-go decision and subsequent suppression of voluntary movements are suggested to be one of the functional features of the human frontal association cortex, as in the case of monkeys.
authors.affiliation: Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Gemba
authors.forename: A
authors.initials: A
authors.lastname: Nambu
authors.forename: R
authors.initials: R
authors.lastname: Matsuzaki
mesh_terms: D000328:Adult; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006225:Hand / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*