[The use of urea carbon 14 in breath tests as diagnostic method for Helicobacter pylori infections].
The Helicobacter Pylori has been indicated as a pathologic agent in the pathogenesis of antral gastritis, gastric and duodenal ulcers and probably in gastric cancer. Due to the high incidence of this infection in our place, we decided to look for a diagnostic method quick to perform, sensitive, reliable and no invasive. The breath test of 14C urea, based in the production of urea by the H. Pylori, represents this alternative. We have found, using does of 1 microCi, a high correlation with the diagnosis of H. Pylori by biopsies. We determined as negative less than 100 DPM, doubtful between 100 and 200 DPM and positive more than 200 DPM. The high pick of the curve keeps tight relation with the degree of infection. We checked this when we suppressed the H. Pylori with bismuth subsalicylate. The breath 14C Urea test showed high sensitivity (100%) and specificity (85.71%). We conclude that this breath test is an alternative way of diagnosing and follow up for H. Pylori infections. It is highly sensitive, reproducible and no invasive.
Vivas
J
J
Centro de Control de Cáncer Gastrointestinal Dr. Luis E. Anderson, San Cristóbal, Táchira, Venezuela.
Contreras
M
M
Mathew
C
C
Peraza
S
S
Maury de Tami
I
I
Oliver
W
W
Cano
E
E
Castro
D
D
Andrade
O
O
Sanchez
V
V
D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods*; D002250:Carbon Radioisotopes; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013997:Time Factors; D014508:Urea / Q000378:metabolism; D014510:Urease / Q000378:metabolism
D002250:Carbon Radioisotopes; D014508:Urea; D014510:Urease
Uso del test úrea carbono14 en el aliento como método de diagnóstico de infección por Helicobacter pylori.