title: Unexpected effects of coffee consumption on liver enzymes.
abstract: The effects of regular daily coffee consumption on liver enzymes were studied in a large number of subjects from the general population. In coffee drinkers, liver enzymes (gamma-glutamyl transferase, alanine-amino transferase, and alkaline phosphatase) and serum bilirubin were lower than in non-coffee-drinking subjects or in those consuming less than 3 cups daily. The hypothesis proposed is that liver enzymes are a target for caffeine contained in coffee.
authors.affiliation: Istituto di Medicina Clinica, Università di Padova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Casiglia
authors.forename: P
authors.initials: P
authors.lastname: Spolaore
authors.forename: G
authors.initials: G
authors.lastname: Ginocchio
authors.forename: G B
authors.initials: GB
authors.lastname: Ambrosio
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D000428:Alcohol Drinking / Q000009:adverse effects; D000469:Alkaline Phosphatase / Q000097:blood*; D000704:Analysis of Variance; D001663:Bilirubin / Q000097:blood*; D001794:Blood Pressure; D002302:Cardiac Output; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D003069:Coffee / Q000009:adverse effects*; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D015999:Multivariate Analysis; D009200:Myocardial Contraction; D015995:Prevalence; D011446:Prospective Studies; D011897:Random Allocation; D012307:Risk Factors; D013318:Stroke Volume; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D003069:Coffee; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin