Behavioral and neurochemical changes produced in rats by developmental treatments with psychotropic drugs.
The timing of developmental administration of psychotropic drugs affecting dopaminergic and GABAergic neurotransmission is crucial for the induction of specific neurobehavioral and neurochemical changes in rodents. Compensatory mechanisms occurring in response to a prolonged treatment with some neuroleptic and anxiolytic agents during development seem to be markedly different from those occurring in response to a prolonged administration in adult animals.
Cagiano
R
R
Istituto di Farmacologia, Facoltà di Medicina e Chirurgia, Università degli Studi, Bari, Italy.
De Salvia
M A
MA
Giustino
A
A
Siro Brigiani
G
G
Cuomo
V
V
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000633:toxicity; D018492:Dopamine Antagonists; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D058787:GABA-A Receptor Antagonists; D005865:Gestational Age; D006130:Growth Disorders / Q000139:chemically induced; D006220:Haloperidol / Q000633:toxicity; D008297:Male; D011247:Pregnancy; D011619:Psychotropic Drugs / Q000633:toxicity*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology
D018492:Dopamine Antagonists; D058787:GABA-A Receptor Antagonists; D011619:Psychotropic Drugs; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D006220:Haloperidol