title: Lipid intolerance does not account for susceptibility to alcoholic and gallstone pancreatitis.
abstract: OBJECTIVE
  Hypertriglyceridemia is an established cause of pancreatitis and has been suggested as a predisposing factor in alcohol and gallstone-induced pancreatitis. The aims of this study were to determine fasting and postprandial triglyceride levels of alcoholics with pancreatitis, alcoholics without pancreatitis, patients with previous gallstone pancreatitis, patients with choledocholithiasis, and healthy controls.
  
  
  METHODS
  Oral lipid tolerance studies were performed in the above groups.
  
  
  RESULTS
  No relationship was found between alcoholic pancreatitis and hypertriglyceridemia, regardless of whether subjects were studied in the fasting state, after ingestion of fat, or after ingestion of fat with ethanol. Plasma triglyceride levels of alcoholics with pancreatitis remained similar to those of alcoholics without pancreatitis, but levels in both groups varied in relation to recent alcohol intake. Plasma triglyceride levels from both groups of alcoholics were greater than those of nonalcoholic healthy subjects. In addition, the previously reported association between postprandial hypertriglyceridemia and gallstone pancreatitis was not observed.
  
  
  CONCLUSIONS
  Plasma triglyceride levels do not account for individual susceptibility to either alcoholic or gallstone pancreatitis.
authors.affiliation: Gastrointestinal Unit, Prince of Wales and Prince Henry Hospitals, Sydney, Australia.
authors.forename: P S
authors.initials: PS
authors.lastname: Haber
authors.forename: J S
authors.initials: JS
authors.lastname: Wilson
authors.forename: M V
authors.initials: MV
authors.lastname: Apte
authors.forename: W
authors.initials: W
authors.lastname: Hall
authors.forename: K
authors.initials: K
authors.lastname: Goumas
authors.forename: R C
authors.initials: RC
authors.lastname: Pirola
mesh_terms: D000437:Alcoholism / Q000097:blood / Q000150:complications*; D001057:Apolipoproteins E / Q000032:analysis / Q000235:genetics; D002769:Cholelithiasis / Q000097:blood / Q000150:complications*; D004198:Disease Susceptibility; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010195:Pancreatitis / Q000097:blood / Q000209:etiology*; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D008055:Lipids; D014280:Triglycerides; D000431:Ethanol