[Effect of azathioprine on immunologic parameters in patients with newly diagnosed insulin-dependent diabetes mellitus].
Azathioprine immunosuppressive therapy prolongs remissions and stimulates residual beta-cell function, suppresses insulin antibody production, reduces the activity of the complement and CH50 components, reduces initially increased cellular immunity parameters (total T and B cell counts, T helper to T inductor ratio, and the count of DR carrier cells) in patients with newly detected insulin-dependent diabetes mellitus; this makes this drug effective at the first stages of the disease. When selecting patients for immunosuppressive therapy the following immunity parameters should be examined: complement status, total counts of T and B lymphocytes, T-helper-inductor/T-suppressor-cytotoxic immunoregulation index, DR carrier cell counts. Reduced levels thereof are a contraindication against immunosuppressant therapy. Male patients with insulin-dependent diabetes mellitus debut at the age of over 25 are particularly susceptible to immunosuppressive therapy with azathioprine.
Shamkhalova
M Sh
MSh
Abugova
I A
IA
Shishko
P I
PI
Dedov
I I
II
Kozlov
L V
LV
Aleshkin
V A
VA
Rozina
M N
MN
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D001379:Azathioprine / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects; D002096:C-Peptide / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003165:Complement System Proteins / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D012074:Remission Induction / Q000379:methods; D012727:Sex Characteristics; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
D002096:C-Peptide; D003165:Complement System Proteins; D001379:Azathioprine
Vliianie azatioprina na immunologicheskie pokazateli u bol'nykh s vpervye vyiavlennym insulinzavisimym sakharnym diabetom.