[The use of glutathione as a protector agent in hypoxic exposure].
The antihypoxic effect of glutathione was studied in a pressure chamber of acute hypoxic hypoxia and in the perfused heart of non-inbred rats. The body's natural metabolite glutathione was found to show the properties of an active antihypoxant, a protector of energy action. The mechanism of this action of glutathione may be associated with decreased hyper-recovery of the mitochondrial respiratory chain and with its restored capacity to synthesize ATP at the first point of oxidative phosphorylation.
Korneev
A A
AA
Komissarova
I A
IA
Nartsissov
Ia R
IaR
D000208:Acute Disease; D000818:Animals; D004198:Disease Susceptibility; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D005978:Glutathione
Ispol'zovanie glutationa v kachestve protektornogo sredstva pri gipoksicheskom vozdeĭstvii.