title: A patient with anaplastic large cell lymphoma (Ki-1 lymphoma) showing clonal integration of HTLV-1 proviral DNA.
abstract: We encountered a patient with anaplastic large cell lymphoma (Ki-1 lymphoma) that originated in the stomach and showed histiocytic lymphoma-like morphology. CD43 antigen was positive, and rearrangement of TCR-beta gene was observed. The lymphoma was the T-cell type. Though no atypical lymphocytes or histological images specific to adult T-cell leukemia were observed, clonal integration of HTLV-1 proviral DNA was noted. Viruses such as HTLV-1 appear to be involved in the development of some anaplastic large cell lymphomas.
authors.affiliation: Department of Internal Medicine, Hiroshima University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takimoto
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: O
authors.initials: O
authors.lastname: Tanabe
authors.forename: A
authors.initials: A
authors.lastname: Kuramoto
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Nanba
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015481:HTLV-I Antibodies / Q000032:analysis; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D008297:Male; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology
chemical_list: D004279:DNA, Viral; D015481:HTLV-I Antibodies