[The GABA-ergic system of the myometrium: a basis for the clinical study of GABA-positive substances as pregnancy protectors].
Radioligand method was used to show 14C-GABA, 3H-flunitrazepam binding sites in human, rat, rabbit myometrium. We have used muscimol, bicucullin, picrotoxin, baclofen, thiosemicarbazide for identification of GABA-benzodiazepine receptor complexes and in pharmacologic analysis of uterine contractility. Receptor affinity depended on pregnancy term (early or late). A conclusion is drawn that GABAA, GABAB, and benzodiazepine receptors of the peripheral nervous system mediate the inhibitory effect of GABA-positive substances on mammalian uterine contractility.
Sergeev
P V
PV
Sizov
P I
PI
Dukhanin
A S
AS
D000818:Animals; D004031:Diestrus / Q000187:drug effects; D005260:Female; D018756:GABA Antagonists; D006801:Humans; D066298:In Vitro Techniques; D009215:Myometrium / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011817:Rabbits; D011869:Radioligand Assay; D051381:Rats; D018079:Receptors, GABA / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects
D018756:GABA Antagonists; D018079:Receptors, GABA
GAMKergicheskaia sistema miometriia: obosnovanie k klinicheskomu izucheniiu GAMK-polozhitel'nykh veshchestv v kachestve gravidoprotektorov.