title: Circulatory and respiratory effects of the combination medetomidine-ketamine in beagles.
abstract: The cardiovascular and respiratory parameters of eight laboratory beagles were measured before and after the simultaneous injection of medetomidine (40 micrograms/kg bw) and ketamine (5 mg/bg bw). This combination produced a significant alteration in cardiovascular function. The heart rate, the stroke volume and cardiac output decreased while the systemic vascular resistance increased. These effects were attributed principally to the alpha 2 agonist compound combined with the moderate stimulatory effect of ketamine. The respiratory parameters were little affected by this protocol.
authors.affiliation: Service d'Anesthésiologie, Faculté de Médecine Vétérinaire Université de Liège, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Serteyn
authors.forename: P
authors.initials: P
authors.lastname: Coppens
authors.forename: R
authors.initials: R
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Verstegen
authors.forename: C
authors.initials: C
authors.lastname: Philippart
authors.forename: M
authors.initials: M
authors.lastname: Lamy
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs / Q000502:physiology*; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D020926:Medetomidine; D012119:Respiration / Q000187:drug effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D007649:Ketamine; D020926:Medetomidine