title: Early cystometrograms can predict the response to intravesical instillation of oxybutynin chloride in myelomeningocele patients.
abstract: Recent reported experiences with intravesical medications in neurogenic bladder patients prompted us to evaluate this form of therapy in 28 myelomeningocele patients who could not tolerate oral anticholinergic agents or did not have adequate control on these agents. A pretreatment cystometrogram was performed followed by intravesical administration of oxybutynin chloride, with a repeat cystometrogram 3 hours later. Patients then began twice daily intravesical oxybutynin for a minimum of 4 months. The mean bladder capacity increased by 41%, the mean intravesical pressure decreased by 47% and compliance improved. Five patients achieved continence and 62% had less wetting while on intravesical therapy. The immediate posttreatment cystometrogram was predictive of the response to intravesical therapy on followup studies. Unfortunately, patient compliance was poor, with only 13 of the 28 patients remaining on therapy for the duration of the study.
authors.affiliation: Children's Hospital of Michigan, Detroit.
authors.forename: J P
authors.initials: JP
authors.lastname: Connor
authors.forename: G
authors.initials: G
authors.lastname: Betrus
authors.forename: P
authors.initials: P
authors.lastname: Fleming
authors.forename: A D
authors.initials: AD
authors.lastname: Perlmutter
authors.forename: C
authors.initials: C
authors.lastname: Reitelman
mesh_terms: D000283:Administration, Intravesical; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D008591:Meningomyelocele / Q000150:complications*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D011312:Pressure; D001743:Urinary Bladder / Q000502:physiology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000209:etiology
chemical_list: D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin