Oxalosis associated with aluminum bone disease: a new type of mixed renal osteodystrophy.
An 18-year-old man suffering from uremia was hospitalized because of severe skeletal pain and multiple exostoses. The patient had been treated for 5 years by regular hemodialysis; primary oxalosis was the suspected cause of uremia. Transiliac bone biopsy and subsequent histomorphometric analysis of undecalcified bone specimen as well as specific aluminum staining revealed a picture of oxalosis combined with osteomalacia and a marked accumulation of aluminum at the front of mineralization. This combination of histological features of oxalosis and aluminum bone disease suggests a new type of mixed renal osteodystrophy.
Krpan
D
D
Internal Clinic, Saint Spirit Hospital, Zagreb, Croatia.
Milutinovic
S
S
Nikolic
V
V
Tomicic
D
D
Lajtman
Z
Z
Prot
F
F
D000293:Adolescent; D000535:Aluminum / Q000378:metabolism*; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000378:metabolism; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D008297:Male; D010018:Osteomalacia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D006435:Renal Dialysis
D000535:Aluminum