[Change in the oxidative metabolism of macrophages during transformation into foam cells].
Oxidative metabolism of murine peritoneal macrophages was studied after cultivation in a mixture containing acetylated low density lipoproteins within 24 and 48 hr using luminol- and lucigenin-dependent chemiluminescence. Chemiluminescence of foamy cells, induced by opsonized zymosan, was not distinctly altered as compared with native macrophages; at the same time, the rate of both lucigenin- and luminol-dependent spontaneous chemiluminescence was distinctly decreased. The imbalance of the oxidative reactions observed enables the authors to propose the antioxidative mechanism of atherosclerotic lesion.
Zenkov
N K
NK
Dushkin
M I
MI
Liubimov
G Iu
GIu
Men'shchikova
E B
EB
D000107:Acetylation; D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D005487:Foam Cells / Q000166:cytology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008163:Luminescent Measurements; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010084:Oxidation-Reduction; D010529:Peritoneal Cavity / Q000166:cytology
D002788:Cholesterol Esters; D008077:Lipoproteins, LDL; D002784:Cholesterol
Izmenenie okislitel'nogo metabolizma makrofagov pri transformatsii v penistye kletki.