[The effect of triorthocresyl phosphate on the toxicity of GABA-lytics for mice].
The toxicity of the picrotoxin bicuculline, but not of 3-mercaptopropionic acid increased in mice pretreated with triorthocresyl phosphate (TOCP). TOCP decreased the affinity of brain GABA receptors of intact mice for [3H] GABA. The binding of [3H]-t-butylcycloorthobenzoate was unchanged. The increased toxicity of GABA-antagonists may be associated with inhibition of blood carboxylesterases. The possibility of direct influence of TOCP and its metabolites on the GABA/benzodiazepine receptor complex cannot be excluded.
Golovko
A I
AI
Sofronov
G A
GA
Nikolaeva
T V
TV
Pluzhnikov
N N
NN
Kliuntina
T V
TV
D015097:3-Mercaptopropionic Acid / Q000633:toxicity; D000818:Animals; D001640:Bicuculline / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000378:metabolism; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000187:drug effects; D004347:Drug Interactions; D018756:GABA Antagonists; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D051379:Mice; D010852:Picrotoxin / Q000633:toxicity; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism; D014317:Tritolyl Phosphates / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism
D015097:3-Mercaptopropionic Acid; D001640:Bicuculline; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002265:Carboxylic Ester Hydrolases; D018756:GABA Antagonists; D008024:Ligands; D010852:Picrotoxin; D014317:Tritolyl Phosphates; D005680:gamma-Aminobutyric Acid; C046308:tert-butylbicyclo-2-benzoate; C025541:tri-o-cresyl phosphate
Vliianie triortokrezilfosfata na toksichnost' GAMK-litikov dlia mysheĭ.