Increased lipid peroxides and inflammatory parameters in the retina adjacent to choroidal melanoma.
Oxidative tissue damage and inflammatory reaction were investigated in the neurosensory retina of five eyes with malignant choroidal melanoma and correlated to the distance from the tumour. The results showed elevated levels of both lipid peroxides (expressed as thiobarbituric acid reactive substances) and myeloperoxidase in the retina adjacent to the tumour. The values declined with distance from the tumour. The results indicate that production of oxygen free radicals contributes to tumour associated retinopathy.
Augustin
A J
AJ
Department of Clinical Ophthalmology, University of Bonn, Germany.
Böker
T
T
Breipohl
W
W
D002830:Choroid Neoplasms / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism*; D012160:Retina / Q000378:metabolism; D012173:Retinitis / Q000473:pathology
D008054:Lipid Peroxides; D009195:Peroxidase