title: Effects of implantation of Alzet 1007D osmotic minipumps upon 2-deoxyglucose uptake in the cerebral cortex of mice.
abstract: The smallest Alzet osmotic minipumps (1007D) were implanted into mouse cerebral cortex. The flow of saline from a minipump produced a large necrosis of cortical tissue and still larger zone of decreased metabolic activity around the site of cannula implantation. Stimulus evoked uptake of 2-deoxyglucose located several millimeters from the implantation site was not affected.
authors.affiliation: Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Jabłońska
authors.forename: M
authors.initials: M
authors.lastname: Gierdalski
authors.forename: A
authors.initials: A
authors.lastname: Kublik
authors.forename: J
authors.initials: J
authors.lastname: Skangiel-Kramska
authors.forename: M
authors.initials: M
authors.lastname: Kossut
mesh_terms: D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D051379:Mice; D010812:Physical Stimulation; D014738:Vibrissae / Q000502:physiology
chemical_list: D003847:Deoxyglucose