[Ambulatory monitoring of blood pressure with a new ACE inhibitor--cilazapril].
OBJECTIVE
To evaluate the tolerability and 24 hours efficacy of a new anti-hypertensive drug: cilazapril.


METHODS
In an open non comparative study 20 hypertensive patients (16 females, age from 30 to 60 years, average = 49.4) were followed for 6 weeks: 2 wash out and 4 treatment (5 mg OD). Blood pressure (BP) was measured by casual and ambulatory blood pressure monitoring (ABPM) readings.


RESULTS
Comparing washout and treatment periods, ABPM averages both for systolic and diastolic BP (mmHg) showed significant decrease in 24 hours, during day and night sub periods. The decrease was not significant between averages considering the "early morning rising pressure" sub period. Heart rate averages showed significant reduction at all sub periods except during night. Adverse effects were mild and resolved spontaneously (n = 3, 15%).


CONCLUSIONS
Cilazapril seems to be efficacious as antihypertensive. Tolerability is excellent. It preserved circadian rhythm despite significantly reducing blood pressure at all periods evaluated except early morning. A bradycardic effect observed mostly during day period should be better evaluated.
Spritzer
N
N
Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia e Cardiopress, Porto Alegre.
Oigman
W
W
D000328:Adult; D000553:Ambulatory Care; D001794:Blood Pressure / Q000187:drug effects*; D017315:Cilazapril / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D017315:Cilazapril
Monitorização ambulatorial da pressão arterial com um novo inibidor da ECA--cilazapril.