Coordinate and independent effects of cocaine, alcohol, and morphine on accumulation of IgG aggregates in the rat glomeruli.
Focal glomerulosclerosis is the predominant glomerular lesion in patients with drug addiction. Since mesangial expansion has been considered a precursor of glomerulosclerosis we investigated whether the use of these drugs can cause accumulation of macromolecules into mesangium which may contribute to the expansion of mesangium. The majority of drug addicts at times take drugs in groups and may thus be exposed to a variety of drugs (cocaine, alcohol, and heroin). Therefore, we studied the effect of cocaine, alcohol, and morphine alone or in combination on the accumulation of radiolabeled human immunoglobulin-G (IgG) aggregates (AHIgG125I) into glomeruli/mesangium. Cocaine enhanced accumulation of AHIgG125I at 8 hr. Glomerular levels of AHIgG125I levels were also higher in morphine treated rats when compared with untreated animals. Alcohol did not alter the deposition of AHIgG125I. But at an earlier time (4 hr) alcohol enhanced the effect of cocaine on accumulation of IgG aggregates into the mesangium. The combined effects of morphine and cocaine, or morphine and alcohol were not different than the effect of morphine alone. The enhanced accumulation of phlogogenic macromolecules into the mesangium may not only increase the quantity of mesangial matrix but may also alter the quality of matrix. This may be playing an important role in the development of glomerular injury.
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Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Singhal
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D000437:Alcoholism / Q000150:complications; D000818:Animals; D003042:Cocaine / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D005920:Glomerular Mesangium / Q000378:metabolism* / Q000648:ultrastructure; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology*; D006046:Gold; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D019966:Substance-Related Disorders / Q000150:complications
D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D000431:Ethanol; D006046:Gold; D009020:Morphine; D003042:Cocaine