title: Development of eosinophilia in dogs intradermically inoculated with sand fly saliva and Leishmania (Leishmania) Chagasi stationary-phase promastigotes.
abstract: Salivary gland lysates of the sand fly Lutzomia longipalpis have been shown to enhance the infectivity of Leishmania in mice. As shown herein, the simultaneous inoculation of Leishmania chagasi stationary-phase promastigotes and L. longipalpis salivary gland lysate by the intradermal route in a group of mongrel dogs induced a statistically significant eosinophilia, in relation to dogs inoculated with Leishmania or with salivary gland lysate only. These dogs had no evidence of infection, in spite of the high infectivity of the promastigotes when inoculated by the intravenous route.
authors.affiliation: Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, Salvador, BA, Brasil.
authors.forename: M
authors.initials: M
authors.lastname: Paranhos
authors.forename: W C
authors.initials: WC
authors.lastname: dos Santos
authors.forename: I
authors.initials: I
authors.lastname: Sherlock
authors.forename: G G
authors.initials: GG
authors.lastname: Oliveira
authors.forename: L C
authors.initials: LC
authors.lastname: de Carvalho
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000469:parasitology*; D004285:Dogs; D004802:Eosinophilia / Q000469:parasitology / Q000662:veterinary*; D018314:Leishmania infantum / Q000472:pathogenicity / Q000502:physiology*; D007898:Leishmaniasis, Visceral / Q000469:parasitology / Q000662:veterinary*; D011576:Psychodidae; D012463:Saliva / Q000469:parasitology*