The CYP1A1 gene and cancer susceptibility.
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.
Kawajiri
K
K
Department of Biochemistry, Saitama Cancer Center Research Institute, Japan.
Nakachi
K
K
Imai
K
K
Watanabe
J
J
Hayashi
S
S
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012907:Smoking / Q000009:adverse effects
D003577:Cytochrome P-450 Enzyme System