Development of neurologic symptoms in a patient with asymptomatic Wilson's disease treated with penicillamine.
OBJECTIVE
To report a case of presymptomatic Wilson's disease in a patient who became severely neurologically disabled after treatment with penicillamine and to discuss alternative initial therapy for such patients.


METHODS
Case report. The patient described is briefly compared with a previously studied group of 13 similar presymptomatic patients who received zinc therapy without any clinical worsening and who have had 3 to 9 years of follow-up.


METHODS
Referral hospital.


METHODS
The patient was referred to us.


METHODS
The patient had initially been treated with penicillamine.


METHODS
The main outcome of interest is permanent neurologic disability, depending on type of initial treatment.


RESULTS
The result of initial penicillamine therapy in the patient described is permanent neurologic disability. This is believed to be due to mobilization and redistribution of hepatic copper causing higher levels of copper in key areas of the brain.


CONCLUSIONS
We conclude that penicillamine used as initial therapy, even in patients with neurologically asymptomatic Wilson's disease, increases the risk of inducing permanent neurologic damage.
Brewer
G J
GJ
Department of Human Genetics, University of Michigan Medical School, Ann Arbor.
Turkay
A
A
Yuzbaziyan-Gurkan
V
V
D000328:Adult; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000150:complications; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D010396:Penicillamine