[The action of nitrobenzene and its chlorine derivatives on the indices of antioxidative homeostasis in rat tissues].
The authors studied the rate of lipid peroxidation, antioxidative activity and content of vitamin E in the liver and spleen of rats given nitrobenzene, o-nitrochlorbenzene and p-nitrochlorbenezene. The xenobiotics increased LPO, antioxidative activity (AOA), splenic levels of vitamin E. The subchronic influence of the substances led to stabilization of LPO, changes in the activation of the body's adaptation. The AOA and vitamin E play an important role in the regulation of antioxidative homeostasis.
Paranich
L I
LI
Paranich
A V
AV
Vasilenko
N M
NM
Bugaĭ
E V
EV
D000818:Animals; D006706:Homeostasis / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009578:Nitrobenzenes / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D009578:Nitrobenzenes; D014810:Vitamin E; C010407:4-chloronitrobenzene; C032785:2-chloronitrobenzene
Deĭstvie nitrobenzola i ego khlor-proizvodnykh na nekotorye pokazateli antiokislitel'nogo gomeostaza v tkaniakh krys.