title: [Considerations in Hodgkin's disease].
abstract: The Authors critically review the problem of Hodgkin's disease (HD) in the light of the most recent findings obtained by means of immunohistochemistry and molecular biology. The following topics are discussed in details: 1) the definition of the borders between HD and non-Hodgkin's lymphomas, 2) the histogenesis of Hodgkin's and Reed-Sternberg cells, 3) the relationships between neoplastic cells and microenvironment, and 4) the pathogenetic role of Epstein-Barr virus in the onset of HD.
authors.affiliation: Istituto di Anatomia e Istologia Patologica e di Ematologia L. & A. Seràgnoli dell'Università di Bologna.
authors.forename: S
authors.initials: S
authors.lastname: Pileri
authors.forename: B
authors.initials: B
authors.lastname: Falini
authors.forename: S
authors.initials: S
authors.lastname: Poggi
authors.forename: M
authors.initials: M
authors.lastname: Benni
authors.forename: M
authors.initials: M
authors.lastname: Bocchia
authors.forename: G
authors.initials: G
authors.lastname: Melilli
authors.forename: E
authors.initials: E
authors.lastname: Sabattini
authors.forename: P L
authors.initials: PL
authors.lastname: Tazzari
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003937:Diagnosis, Differential; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D009857:Oncogenes; D010641:Phenotype; D014412:Tumor Virus Infections / Q000382:microbiology
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Considerazioni in tema di malattia di Hodgkin.