Guidelines for the safe administration of inhaled nitric oxide.
Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.
Miller
O I
OI
Cardiothoracic Unit, Hospital for Sick Children, London.
Celermajer
D S
DS
Deanfield
J E
JE
Macrae
D J
DJ
D000280:Administration, Inhalation; D004334:Drug Administration Schedule; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy; D007223:Infant; D008954:Models, Biological; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D009585:Nitrogen Dioxide / Q000378:metabolism; D012121:Respiration, Artificial / Q000592:standards*
D009569:Nitric Oxide; D009585:Nitrogen Dioxide