title: Metal compounds in therapy and diagnosis.
abstract: There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension. The use of metal radionuclides in diagnosis and radiotherapy and the role of paramagnetic metal complexes as contrast agents in magnetic resonance imaging are also discussed.
authors.affiliation: Biomedical Research Worldwide, Johnson Matthey, Inc., West Chester, PA 19380.
authors.forename: M J
authors.initials: MJ
authors.lastname: Abrams
authors.forename: B A
authors.initials: BA
authors.lastname: Murrer
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy; D003952:Diagnostic Imaging; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy; D009569:Nitric Oxide / Q000378:metabolism; D009599:Nitroprusside / Q000378:metabolism / Q000627:therapeutic use; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use; D013667:Technetium; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D000970:Antineoplastic Agents; D018501:Antirheumatic Agents; D050607:Organogold Compounds; D009942:Organometallic Compounds; D011868:Radioisotopes; D014665:Vasodilator Agents; D009599:Nitroprusside; D009569:Nitric Oxide; D013667:Technetium