title: Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus).
abstract: Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with 123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower 123I-IBZM binding in the basal ganglia compared to the control group. The results indicate a loss of central D2 receptors in PMS.
authors.affiliation: Department of Psychiatry, Georg August University, Göttingen, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Staedt
authors.forename: G
authors.initials: G
authors.lastname: Stoppe
authors.forename: A
authors.initials: A
authors.lastname: Kögler
authors.forename: D
authors.initials: D
authors.lastname: Munz
authors.forename: H
authors.initials: H
authors.lastname: Riemann
authors.forename: D
authors.initials: D
authors.lastname: Emrich
authors.forename: E
authors.initials: E
authors.lastname: Rüther
mesh_terms: D000328:Adult; D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D010507:Periodicity; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012893:Sleep Wake Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015259:Dopamine Agents; D017448:Receptors, Dopamine D2