title: Influence of previous exposure to human parvovirus B19 infection in explaining susceptibility to rheumatoid arthritis: an analysis of disease discordant twin pairs.
abstract: OBJECTIVE
  To assess the association between exposure to parvovirus B19 and susceptibility to rheumatoid arthritis (RA).
  
  
  METHODS
  One hundred and fifty five twin pairs (76 monozygotic (MZ) and 79 dizygotic (DZ)), discordant for RA, were tested for the presence of IgG antiparvovirus antibodies using ELISA. The data obtained were analysed using conditional logistic regression, from which odds ratios and 95% confidence intervals were calculated.
  
  
  RESULTS
  Overall, there was no association between exposure to parvovirus and RA (OR = 1.2, 95% CI: 0.7-1.7). However, in two subgroups there was a suggestion of an association. These were: (1) pairs where the affected twin was rheumatoid factor (RF) seronegative (OR = 2.0, 95% CI: 0.9-12.4) and (2) in opposite-sexed twin pairs where the affected twin was female (OR = 3.0, 95% CI: 0.9-11.6).
  
  
  CONCLUSIONS
  Previous exposure to parvovirus infection did not explain disease susceptibility in both MZ and DZ discordant pairs with rheumatoid arthritis. This infection, however, might be relevant in some subgroups.
authors.affiliation: ARC Epidemiology Research Unit, Manchester University Medical School, United Kingdom.
authors.forename: A H
authors.initials: AH
authors.lastname: Hajeer
authors.forename: A J
authors.initials: AJ
authors.lastname: MacGregor
authors.forename: A S
authors.initials: AS
authors.lastname: Rigby
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
authors.forename: D
authors.initials: D
authors.lastname: Carthy
authors.forename: A J
authors.initials: AJ
authors.lastname: Silman
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D004198:Disease Susceptibility; D004200:Diseases in Twins; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016732:Parvovirus B19, Human / Q000276:immunology; D012307:Risk Factors; D012737:Sex Factors; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D000914:Antibodies, Viral