Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway.
In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.
Raybould
H E
HE
Department of Medicine, CURE/UCLA Digestive Diseases Center.
Holzer
H
H
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology*
D012633:Secretin; D002766:Cholecystokinin; D002211:Capsaicin