Erythromycin ototoxicity in liver transplant patients.
We report on three liver transplant patients who developed erythromycin-related ototoxicity. This complication has been described in renal transplant patients and in patients with liver dysfunction, but to our knowledge it has not yet been reported in liver transplant patients. The influence of hepatic dysfunction, common renal failure, and the interaction between cyclosporin and erythromycin in the development of erythromycin ototoxicity are discussed.
Moral
A
A
Department of Surgery, Hospital Clinic, University of Barcelona, Spain.
Navasa
M
M
Rimola
A
A
García-Valdecasas
J C
JC
Grande
L
L
Visa
J
J
Rodés
J
J
D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage; D004347:Drug Interactions; D004917:Erythromycin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006312:Hearing Loss, Bilateral / Q000139:chemically induced*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy
D004917:Erythromycin; D016572:Cyclosporine