title: Acute toxicity of vitamin A given with vaccines in infancy.
abstract: A double-blind, randomised, placebo-controlled trial was conducted to evaluate the safety and toxicity of vitamin A supplementation within the Expanded Programme on Immunisation (EPI) in rural Bangladesh. 191 infants received 3 doses of either 50,000 IU of vitamin A or placebo at about 1.5, 2.5, and 3.5 months and were examined on days 1, 2, 3, and 8 after supplementation. 11 infants (11.5%) supplemented with vitamin A had episodes of bulging of the fontanelle as opposed to 1 (1%) in the placebo group. 16 of the 17 events occurred in the vitamin A supplemented group. No other side effects were noted. There was a tendency towards a cumulative effect of toxicity with increasing doses.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
authors.forename: A
authors.initials: A
authors.lastname: de Francisco
authors.forename: J
authors.initials: J
authors.lastname: Chakraborty
authors.forename: H R
authors.initials: HR
authors.lastname: Chowdhury
authors.forename: M
authors.initials: M
authors.lastname: Yunus
authors.forename: A H
authors.initials: AH
authors.lastname: Baqui
authors.forename: A K
authors.initials: AK
authors.lastname: Siddique
authors.forename: R B
authors.initials: RB
authors.lastname: Sack
mesh_terms: D001459:Bangladesh; D003393:Cranial Sutures / Q000187:drug effects* / Q000473:pathology; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007427:Intracranial Pressure; D014611:Vaccination; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014801:Vitamin A