title: Analgesic efficiency of propacetamol hydrochlorid after lumbar disc surgery.
abstract: The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients scheduled for lumbar disc surgery were randomly allocated to two groups. They were given either propacetamol 2 g or saline every 6 hours, starting at the end of procedure for a 24 hours period. The pain intensity (VAS) was not significantly different between the two groups except 3 and 4 hours after surgery, where it was higher in the paracetamol group. The cumulative narcotic consumption (piritramide on request) was higher in the placebo group from 6 hours till 9 hours after surgery but not significantly different after 24 hours. Piritramide administration decreased VAS score significantly in both groups while propacetamol reduced it in a significant way only when given from 12 hours after surgery.
authors.affiliation: University Department of Anesthesiology and Intensive Care, CHR de la Citadelle, Liège.
authors.forename: P
authors.initials: P
authors.lastname: Hans
authors.forename: J F
authors.initials: JF
authors.lastname: Brichant
authors.forename: V
authors.initials: V
authors.lastname: Bonhomme
authors.forename: M
authors.initials: M
authors.lastname: Triffaux
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D010892:Pirinitramide / Q000627:therapeutic use; D011355:Prodrugs; D013997:Time Factors
chemical_list: D000700:Analgesics; D011355:Prodrugs; D000082:Acetaminophen; D010892:Pirinitramide; C063776:propacetamol