title: Methylphenidate decreases regional cerebral blood flow in normal human subjects.
abstract: To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5 mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25 +/- 11%) and at 30 minutes (20 +/- 10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.
authors.affiliation: Medical Department, Brookhaven National Laboratory, Upton, New York, 11973.
authors.forename: G J
authors.initials: GJ
authors.lastname: Wang
authors.forename: N D
authors.initials: ND
authors.lastname: Volkow
authors.forename: J S
authors.initials: JS
authors.lastname: Fowler
authors.forename: R
authors.initials: R
authors.lastname: Ferrieri
authors.forename: D J
authors.initials: DJ
authors.lastname: Schlyer
authors.forename: D
authors.initials: D
authors.lastname: Alexoff
authors.forename: N
authors.initials: N
authors.lastname: Pappas
authors.forename: J
authors.initials: J
authors.lastname: Lieberman
authors.forename: P
authors.initials: P
authors.lastname: King
authors.forename: D
authors.initials: D
authors.lastname: Warner
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003864:Depression, Chemical; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008774:Methylphenidate / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D008774:Methylphenidate