Carotid artery disease in vascular ocular syndromes.
We prospectively investigated 83 consecutive patients with vascular ocular syndromes: 19 suffered from amaurosis fugax attacks, 23 had occlusions of the central retinal artery or a branch retinal artery occlusion, 26 had a central retinal vein occlusion or a branch retinal vein occlusion, and another 15 exhibited an anterior ischemic optic neuropathy. In 5 patients bilateral symptoms occurred; thus a total of 88 eyes were affected. All patients underwent a neurological examination and ultrasound investigations of the carotid arteries, including continuous wave (cw)-Doppler-sonography and duplex ultrasound. Stenosis of more than 50% diameter reduction and occlusion of the internal carotid artery ipsilateral to the symptomatic eye were significantly more frequent in amaurosis fugax attacks and central or branch retinal artery occlusion than in central or branch retinal vein occlusion or anterior ischemic optic neuropathy (p < .025). Additionally, the analysis of plaque surface and echogenicity of the plaques on the affected side with a high-resolution duplex scan uncovered that ulcerated plaque surfaces and plaques with a heterogeneous echogenicity were found significantly more frequent in the internal carotid arteries of patients with amaurosis fugax attacks and central or branch retinal artery occlusions than in patients with anterior ischemic optic neuropathy (p < .04) or central and branch retinal vein occlusion (p < .025). We conclude that amaurosis fugax attacks and central retinal artery or branch retinal artery occlusions are due to arterio-arterial embolization from ulcerated and heterogeneous carotid artery plaques.(ABSTRACT TRUNCATED AT 250 WORDS)
Müller
M
M
Department of Neurology, Medical University of Lübeck, Germany.
Wessel
K
K
Mehdorn
E
E
Kömpf
D
D
Kessler
C M
CM
D000368:Aged; D001161:Arteriosclerosis / Q000150:complications* / Q000000981:diagnostic imaging; D001766:Blindness / Q000209:etiology; D002340:Carotid Artery Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000000981:diagnostic imaging; D008297:Male; D009900:Optic Nerve / Q000098:blood supply; D011446:Prospective Studies; D015356:Retinal Artery Occlusion / Q000150:complications* / Q000000981:diagnostic imaging; D012307:Risk Factors; D013577:Syndrome; D014463:Ultrasonography