title: Intravitreal application of membrane-permeable analogs of cyclic GMP increases serotonin N-acetyltransferase (NAT) activity in retinas of light-exposed chicks: comparison with the effect of cyclic AMP analogs and darkness.
abstract: Intravitreal administration of membrane-permeable analogs of cGMP and cAMP markedly enhanced serotonin N-acetyltransferase (NAT) activity in retinas of light-exposed chicks. The effects of cGMP analogs were usually weaker than the actions of cAMP analogs, however, they were more pronounced than the effects of non-cyclic derivative of GMP (i.e., 8-bromo-GMP). Combined treatment with dibutyryl-derivatives of cGMP and cAMP yielded NAT values that were similar to the values produced by the compounds administered separately, whereas NAT activity in chicks receiving a combination of db-cGMP and aminophylline was higher than the enzyme activity produced by the drugs individually. Neither db-cGMP nor aminophylline affected hydroxyindole-O-methyltransferase (HIOMT) activity in retinas of light-exposed chicks. It is hypothesized that cGMP analogs enhance the retinal NAT activity indirectly, via cAMP.
authors.affiliation: Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Nowak
authors.forename: M
authors.initials: M
authors.lastname: Wawrocka
mesh_terms: D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D003994:Bucladesine / Q000494:pharmacology; D002645:Chickens; D006152:Cyclic GMP / Q000008:administration & dosage / Q000494:pharmacology*; D003624:Darkness; D007267:Injections; D008027:Light; D008297:Male; D008550:Melatonin / Q000096:biosynthesis; D012160:Retina / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D014822:Vitreous Body
chemical_list: D015124:8-Bromo Cyclic Adenosine Monophosphate; D000628:Aminophylline; D003994:Bucladesine; D000121:Acetylserotonin O-Methyltransferase; D001191:Arylamine N-Acetyltransferase; D006152:Cyclic GMP; D008550:Melatonin