Alcoholysis of epsilon-decalactone with polyethylene glycol-modified lipase in 1,1,1-trichloroethane.
Lipase from Pseudomonas cepacia was modified with 2,4-bis[O-methoxypoly(ethylene glycol)]-6-chloro-s-triazine, activated PEG2, to form PEG-lipase. The PEG-lipase is soluble and active in organic solvents. It catalyzes alcoholysis of racemic epsilon-decalactone with ethanol in 1,1,1-trichloroethane to form (R)-hydroxydecanoic acid ethyl ester. No alcoholysis of (S)-decalactone takes place. These results were discussed in relation to carbon number of n-alcohol, optimum temperature and comparison with modified and non-modified lipases.
Furukawa
M
M
Department of Materials Science and Technology, Toin University of Yokohama, Japan.
Kodera
Y
Y
Uemura
T
T
Hiroto
M
M
Matsushima
A
A
Kuno
H
H
Matsushita
H
H
Inada
Y
Y
D005026:Ethylene Glycols / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D012997:Solvents; D014240:Trichloroethanes / Q000737:chemistry
D005026:Ethylene Glycols; D007783:Lactones; D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; C052208:epsilon-decalactone