title: Fibrin adhesive in radical mastectomy.
abstract: OBJECTIVE
  To find out if fibrin adhesive glue applied locally would reduce the incidence of seroma after modified radical mastectomy for breast cancer.
  
  
  METHODS
  Prospective randomised study.
  
  
  METHODS
  City hospital, Sweden.
  
  
  METHODS
  68 women undergoing modified radical mastectomy with axillary clearance for breast cancer.
  
  
  METHODS
  Amount of postoperative drainage, number of seromas aspirated volumes; length of hospital stay, influence of surgeon operating.
  
  
  RESULTS
  Seromas developed in a total of 40/68 patients (59%), 23/36 in the fibrin adhesive group (64%) and 17/32 in the control group (53%); p = 0.5 (95% confidence interval of the difference--0.13 to 0.34). There were no significant differences in the volume of aspirations or in hospital stay. The skill of the surgeon influenced the incidence of seromas, but the differences were not significant (p = 0.5).
  
  
  CONCLUSIONS
  Local application of a fibrin adhesive glue has no effect on the incidence of seroma formation after modified radical mastectomy.
authors.affiliation: Department of Surgery, Malmö Allmänna sjukhus, Lund University, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Udén
authors.forename: K
authors.initials: K
authors.lastname: Aspegren
authors.forename: G
authors.initials: G
authors.lastname: Balldin
authors.forename: J P
authors.initials: JP
authors.lastname: Garne
authors.forename: S A
authors.initials: SA
authors.lastname: Larsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000601:surgery; D004322:Drainage; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D007902:Length of Stay; D015409:Mastectomy, Radical / Q000379:methods; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011446:Prospective Studies
chemical_list: D015718:Fibrin Tissue Adhesive