Electroconvulsive shock decreases excitatory responses to serotonin in the caudate nucleus of the rat.
1. The present study explored the changes on the firing rate of caudate neurons, and the response to serotonin locally applied in rats submitted to electroconvulsive shock. 2. Electroconvulsive shock diminished the firing rate of caudate neurons and blocked the excitatory response produced by serotonin in a small amount of serotonin-sensitive neurons. 3. Results are likely to be related with transient changes in the receptor's affinity and dissociation constants, which may impinge on immediate memory retrieval.
Contreras
C M
CM
Laboratorio de Neurofarmacología, Universidad Veracruzana, México.
Sánchez Estrada
G
G
Molina Hernández
M
M
Marvan
M L
ML
D000818:Animals; D002421:Caudate Nucleus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D004597:Electroshock; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012701:Serotonin