title: A diet rich in monounsaturated rapeseed oil reduces the lipoprotein cholesterol concentration and increases the relative content of n-3 fatty acids in serum in hyperlipidemic subjects.
abstract: The effects of 3 wk on a diet rich in monounsaturated rapeseed oil were compared with those of a diet containing sunflower oil within a lipid-lowering diet. Ninety-five subjects with moderate hyperlipoproteinemia were randomly assigned to one of the two well-controlled diets prepared at the hospital kitchen. Total serum, low-density- and high-density-lipoprotein cholesterol concentrations decreased by 15%, 16%, and 11% (P < 0.001), respectively, on the rapeseed oil diet and by 16%, 14%, and 13% (P < 0.001) on the sunflower oil diet. Serum triglycerides decreased more markedly (by 29%, P < 0.001) on the sunflower oil than on the rapeseed oil diet (14%, P < 0.01). The n-3 fatty acids (20:5 and 22:5) in the serum phospholipids increased significantly on the rapeseed oil diet but decreased on the sunflower oil diet. There was an increase in the alpha-tocopherol concentrations after both diets. The findings indicate that low erucic acid rapeseed oil can replace oils and fats rich in polyunsaturated fatty acids in a lipid-lowering diet.
authors.affiliation: Department of Geriatrics, Uppsala University, Sweden.
authors.forename: I B
authors.initials: IB
authors.lastname: Gustafsson
authors.forename: B
authors.initials: B
authors.lastname: Vessby
authors.forename: M
authors.initials: M
authors.lastname: Ohrvall
authors.forename: M
authors.initials: M
authors.lastname: Nydahl
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000032:analysis / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001937:Brassica; D002784:Cholesterol / Q000097:blood*; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D006368:Helianthus; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood* / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010938:Plant Oils; D000074262:Rapeseed Oil; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood*
chemical_list: D001053:Apolipoproteins; D001786:Blood Glucose; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D007328:Insulin; D008074:Lipoproteins; D010938:Plant Oils; D000074262:Rapeseed Oil; D000074242:Sunflower Oil; D014280:Triglycerides; D002784:Cholesterol