title: The study of histamine H1- and H2-receptors in human lung cancer.
abstract: Data on human lung histamine H1- and H2-receptors in cancer and chronic inflammatory processes are reported. It has been found that the number of histamine H1-receptors significantly increases both in cancer and chronic pneumonia and does not practically change in tuberculosis lung parenchyma. The binding parameters of histamine H2-receptors both in cancer and inflammatory processes were similar to those obtained for the normal tissue. The important role of parenchymal histamine H1-receptors in the neuromodulation of airways in human lung adenocarcinoma is discussed.
authors.affiliation: Research Center of Molecular Diagnostics and Therapy, Moscow, Russia.
authors.forename: T Y
authors.initials: TY
authors.lastname: Kondratenko
authors.forename: I V
authors.initials: IV
authors.lastname: Zacharova
authors.lastname: Katukov VYu
authors.forename: N V
authors.initials: NV
authors.lastname: Kuzina
authors.forename: E S
authors.initials: ES
authors.lastname: Severin
authors.forename: Z Ch
authors.initials: ZCh
authors.lastname: Kornilova
authors.forename: M I
authors.initials: MI
authors.lastname: Perelman
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000150:complications / Q000503:physiopathology; D000328:Adult; D000402:Airway Obstruction / Q000209:etiology / Q000503:physiopathology; D002908:Chronic Disease; D002927:Cimetidine / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis* / Q000502:physiology; D011014:Pneumonia / Q000378:metabolism; D011738:Pyrilamine / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000032:analysis* / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000032:analysis* / Q000502:physiology; D014375:Tuberculoma / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002927:Cimetidine; D011738:Pyrilamine