Interaction of glucose signals between the nucleus of the vagus nerve and the portal vein area in the regulation of gastric motility in rats.
Intragastric pressures were examined after glucose injection into the nucleus of the vagus nerve (X) of the medulla oblongata or into the portal vein (PV) or both in bilaterally adrenalectomized rats. Ten mM glucose (500 nl) injected into the X or into the PV (25 microliters) decreased gastric pressure associated with insulin-hypoglycemia. Simultaneous injection of glucose into the X and PV produced a reduction in gastric pressure in an additive manner. In addition, a significant fall in gastric pressure was seen when an ineffective concentration of glucose was injected into the X and PV simultaneously. The results suggest that the X and PV signals interact with each other to inhibit gastric motility.
Sakaguchi
T
T
Department of Physiology, Niigata University School of Medicine, Japan.
Aono
T
T
Ohtake
M
M
Sandoh
N
N
D000315:Adrenalectomy; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000502:physiology*; D005947:Glucose / Q000502:physiology*; D007328:Insulin / Q000097:blood; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D011169:Portal Vein / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose