[Molluscacidal activity of spiro-alpha-methylene-gamma-butyrolactone].
The alpha-methylene-gamma-butyrolactones 1-28 were tested in vitro for molluscicidal activity against Biomphalaria glabrata. The racemic compound 25 shows the best activity. The synthesis was carried out by modified Reformatzky reaction of the corresponding carbonyl compounds and bromomethylacrylic acid ethyl ester. 7-10, 17 and 22-27 have been synthesized for the first time.
Rücker
G
G
Pharmazeutisches Institut, Rheinischen Friedrich-Wilhelms-Universität Bonn.
Hostettmann
K
K
Gajewski
W
W
Löbbert
M
M
Böken
P
P
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001700:Biomphalaria / Q000502:physiology*; D008975:Molluscacides / Q000138:chemical synthesis* / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D008975:Molluscacides; D013141:Spiro Compounds; D015107:4-Butyrolactone
Molluskizid wirksame Spiro-alpha-methylen-gamma-butyrolactone.