[The replacement of accessory T-lymphocytes by synthetic peptides during the formation of splenic hematopoietic colonies].
Whether accessory T cells can be replaced by the synthetic immunomodulators thymogen (Glu-Trp) and thymohexin (Arg-Lys-Asp-Val-Tyr-Arg) was studied. The latter immunomodulator was found to show a 3-fold increase in splenic colony formation after incubation of bone marrow cells with rabbit antimouse brain serum (RAMBS). The former preparation failed to show the same action. Its effect was close to that of thymocytes. When the recipients exposed to lethal irradiation were administered the RAMBS-treated bone marrow cells and one of the peptides, it was shown that in concomitant administration, thymohexin and thymocytes lost their ability to restore colony formation by RAMBS-treated bone marrow. Thymogen did not suppress the stimulating activity of thymocytes. It is suggested that the differences observed between the tested peptides in their ability to recover colony formation were determined by their structure.
Semina
O V
OV
Semenets
T N
TN
Deĭgin
V I
VI
Korotkov
A M
AM
Poverennyĭ
A M
AM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D001921:Brain / Q000276:immunology; D003114:Colony-Forming Units Assay; D004151:Dipeptides; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D007106:Immune Sera / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D007106:Immune Sera; D009842:Oligopeptides; D010455:Peptides; C080035:thymohexin; C060736:thymogen
Zamena aktsessornykh T-limfotsitov sinteticheskimi peptidami v protsesse formirovaniia selezenochnykh krovetvornykh koloniĭ.