[Cephalosporins as possible methods of etiotropic therapy of tuberculosis].
Cephalosporin antibiotics cefamezin (I generation drug sensitive to beta-lactamase) and cefotaxime (III generation drug resistant to beta-lactamase) have been tested for antituberculous activity. The latter was found dependent on resistance to mycobacterial beta-lactamase. A minimal inhibiting concentration of cefotaxime was similar to that of etambutol and tisamid. Cefotaxime also enhanced tuberculostatic and bactericidal effect of isoniazid and rifampicin. Combination cefotaxime+isoniazid+rifampicin proved more effective than cefotaxime+etambutol+tisamid. The effectiveness against tuberculosis of the beta-lactamase resistant cephalosporin points to the validity of further research for active phthisiatric drugs among III generation cephalosporins.
Vinogradova
T I
TI
Aleksandrova
A E
AE
Tschegoleva
R A
RA
D000818:Animals; D002437:Cefazolin / Q000627:therapeutic use; D002439:Cefotaxime / Q000627:therapeutic use; D002478:Cells, Cultured; D002511:Cephalosporins / Q000627:therapeutic use*; D003470:Culture Media; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D051379:Mice; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
D002511:Cephalosporins; D003470:Culture Media; D004977:Ethambutol; D002437:Cefazolin; D002439:Cefotaxime; D007538:Isoniazid; D012293:Rifampin
Tsefalosporiny kak vozmozhnye sredstva étiotropnoĭ terapii tuberkulëza.