title: Reproduction of progressive retinal degeneration (bright blindness) in sheep by administration of ptaquiloside contained in bracken.
abstract: The process of occurrence of bright blindness, progressive retinal degeneration (PRD), in sheep was observed using two Suffolk ram lambs fed on a diet containing bracken powder. The first sign of the bright blindness was detected 4 months after the start of experiment. Based on these preliminary results, the amount of bracken powder necessary to induce PRD was estimated (experiment I). In the following experiment, ptaquiloside (PT), a norsesquiterpene glucoside of the illudane type isolated from bracken, which is a bracken carcinogen and a causative principle of cattle bracken poisoning was administered to two Suffolk ram lambs. It was clearly demonstrated in this experiment (experiment II) that PT present in bracken is also a causative principle of PRD.
authors.affiliation: Department of Pathology, School of Medicine, Fujita Health University, Aichi, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Hirono
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Yagyu
authors.forename: M
authors.initials: M
authors.lastname: Haga
authors.forename: K
authors.initials: K
authors.lastname: Wakamatsu
authors.forename: T
authors.initials: T
authors.lastname: Kishikawa
authors.forename: O
authors.initials: O
authors.lastname: Nishikawa
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Ojika
authors.forename: H
authors.initials: H
authors.lastname: Kigoshi
mesh_terms: D000821:Animal Feed; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D007189:Indans; D008297:Male; D010786:Photoreceptor Cells / Q000473:pathology; D010939:Plant Poisoning / Q000473:pathology / Q000662:veterinary*; D012160:Retina / Q000473:pathology; D012162:Retinal Degeneration / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D012717:Sesquiterpenes; D012756:Sheep; D012757:Sheep Diseases; D013729:Terpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D007189:Indans; D012717:Sesquiterpenes; D013729:Terpenes; C043680:ptaquiloside