[Syndrome of allopurinol hypersensitivity. Report of a new case and review of the Spanish literature].
Allopurinol is a drug of wide clinical use and good tolerance. Some patients develop severe hypersensitivity due to immunologic reaction to the drug. A new case which fulfills all the diagnostic criteria of the syndrome of allopurinol hypersensitivity with associated clinical manifestations of multiple mononeuritis and evidence of granulomas and vasculitis in liver biopsy as the most significant data is reported. The syndrome was favorably resolved following withdrawal of the drug without need for corticoid therapy. The characteristics of the cases described in the Spanish literature over the last few years are globally reviewed. The absence of mortality is of note. The inconvenience of prescribing allopurinol to patients with asymptomatic hyperuricemia is emphasized.
Berbegal
J
J
Servicio de Medicina Interna, Hospital Marina Alta, Denia, Alicante.
Morera
J
J
Andrada
E
E
Navarro
V
V
Lluch
V
V
López-Benito
I
I
D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000473:pathology; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D009443:Neuritis / Q000139:chemically induced / Q000473:pathology; D013030:Spain; D013577:Syndrome; D014657:Vasculitis / Q000139:chemically induced / Q000473:pathology
D000493:Allopurinol
Síndrome de hipersensibilidad al alopurinol. Aportación de un nuevo caso y revisión de la literatura española.