Utilization of a glucose/fructose/xylitol carbohydrate solution during surgery.
The utilization of a 4:2:1 mixture of glucose, fructose, and xylitol (GFX) was studied by indirect calorimetry in patients undergoing abdominal surgery. Sixteen patients undergoing gastrectomy under general anesthesia received GFX intravenously at 0.25 g/kg h-1 during surgery. VO2, VCO2, and RQ were measured continuously for 150 min using an Engström metabolic computer, and urea nitrogen excretion was determined at 30-min intervals during surgery. Blood levels of glucose, fructose, and xylitol plateaued after 1 h. The RQ decreased over the first 90 min from 0.84 +/- 0.06 to 0.75 +/- 0.05 and then gradually increased to 0.79 +/- 0.04 at 150 min. VO2 did not change significantly over the 150-min period. From the RQ, VO2, and nitrogen excretion data, carbohydrate oxidation was estimated. The amount of carbohydrate oxidized was 9.7 +/- 6.9 g during the first 30-min period, 3.5 +/- 5.2 g during the 60 to 90-min period, and 7.5 +/- 4.5 g in the 120 to 150-min study period. Simultaneously, lipid oxidation increased. These observations suggest that the GFX solution is adequately metabolized during surgery and therefore may be a suitable energy source for patients.
Kawachi
S
S
Department of Anesthesia, Matsue Red Cross Hospital, Japan.
Sumiyoshi
N
N
Yamamori
Y
Y
Kaneko
M
M
Yuge
O
O
D000005:Abdomen / Q000601:surgery*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism*; D005743:Gastrectomy; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D012123:Pulmonary Ventilation; D014993:Xylitol / Q000008:administration & dosage / Q000378:metabolism*
D005632:Fructose; D005947:Glucose; D014993:Xylitol