Microbial contaminants found in low egg passage rabies vaccine used in Nigeria.
Bacteriological and mycological examinations (cultural and biochemical characteristics) identified 4 pathogenic organisms as contaminants in 6 out of 7 LEP batch 20 rabies vaccines produced 1990 in Nigeria. Cryptococcus neoformans and Penicillium spp. were isolated from 5 vaccine samples, while one sample additionally also contained Rhizopus and Pseudomonas. One vaccine sample was negative for microbial contaminants. Improper conditions of vaccine production and storage are discussed.
Adeyemi
I G
IG
Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Nigeria.
Ikheloa
J O
JO
Ogundipe
G A
GA
D000818:Animals; D001419:Bacteria / Q000302:isolation & purification*; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D004340:Drug Contamination; D005658:Fungi / Q000302:isolation & purification*; D009549:Nigeria; D010407:Penicillium / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D011819:Rabies Vaccines / Q000592:standards*; D012233:Rhizopus / Q000302:isolation & purification
D011819:Rabies Vaccines