Effect of transdermal oestradiol on the haemostatic balance of menopausal women.
OBJECTIVE
To determine the effect of transdermal oestrogen replacement therapy on the haemostatic balance of menopausal women.


METHODS
Open, parallel group, prospective study.


METHODS
Three hospital-based menopause clinics.


METHODS
Fifty-two postmenopausal women receiving transdermal hormone replacement therapy (Estrapak 50) for 6 months. Comparison group of 48 untreated postmenopausal women studied in parallel.


METHODS
Changes in platelet number, plasma concentrations of coagulation factors and their natural inhibitors, fibrinolytic activity, and rheological parameters.


RESULTS
Estrapak 50 had no significant thrombophilic effect on any of the outcome measures.


CONCLUSIONS
The haemostatic balance and thus the risk of thrombosis would not appear to be upset by this dose of transdermal oestrogen.
Fox
J
J
Midlands Menopause Study Group: Birmingham Maternity Hospital, UK.
George
A J
AJ
Newton
J R
JR
Parsons
A D
AD
Stuart
G K
GK
Stuart
J
J
Sturdee
D W
DW
D000279:Administration, Cutaneous; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000032:analysis / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011446:Prospective Studies
D001779:Blood Coagulation Factors; D004958:Estradiol