title: The oxygen cost of breathing may predict weaning from mechanical ventilation better than the respiratory rate to tidal volume ratio.
abstract: OBJECTIVE
  To compare the respiratory rate to tidal volume ratio with the oxygen cost of breathing to see which could more accurately predict the outcome of ventilator weaning for surgical patients.
  
  
  METHODS
  Prospective comparison of two modalities used to predict the likelihood of successful ventilator weaning.
  
  
  METHODS
  Twenty-eight consecutive patients with chronic respiratory insufficiency requiring long-term mechanical ventilation in the surgical intensive care unit at New England Deaconess Hospital, Boston, Mass, were studied.
  
  
  METHODS
  The oxygen cost of breathing and the respiratory rate to tidal volume ratio were measured during spontaneous breathing. Patients extubated within 2 weeks of being studied were designated as extubated while patients not extubated within this period or requiring reintubation were recorded as not extubated.
  
  
  RESULTS
  The oxygen cost of breathing predicted successful extubation in all five patients who were extubated, and failure in 20 of 23 patients who could not be extubated (sensitivity, 100%; specificity, 87%). In contrast, the respiratory rate to tidal volume ratio predicted extubation for only two of five patients who were extubated and predicted failure in only 12 of 23 patients who could not be extubated (sensitivity, 40%; specificity, 52%).
  
  
  CONCLUSIONS
  For this group of patients requiring prolonged ventilation, the oxygen cost of breathing proved to be a more reliable predictor of both successful extubation and failure.
authors.affiliation: Department of Surgery, Wilford Hall USAF Medical Center, Lackland AFB, Texas.
authors.forename: S A
authors.initials: SA
authors.lastname: Shikora
authors.forename: P N
authors.initials: PN
authors.lastname: Benotti
authors.forename: J A
authors.initials: JA
authors.lastname: Johannigman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000502:physiology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012119:Respiration / Q000502:physiology*; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy; D012680:Sensitivity and Specificity; D013990:Tidal Volume / Q000502:physiology*; D015300:Ventilator Weaning; D014939:Work of Breathing / Q000502:physiology*
chemical_list: D010100:Oxygen