A placebo-controlled trial of trihexyphenidyl in unmedicated patients with schizophrenia.
Seventeen patients with schizophrenia who had been free of medication for at least 2 months entered a placebo-controlled, random-order crossover trial of 5 mg of trihexyphenidyl twice daily for 4 weeks. Ten patients completed trials of both drug and placebo. Ratings of anticholinergic symptoms and of feeling the effects of the drug, controlled for order effects, were significantly higher at week 4 of the trihexyphenidyl trial than at week 4 of the placebo trial. Measures of psychosis, negative symptoms, depression, and liking the drug did not differ between trihexyphenidyl and placebo trials.
Goff
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Erich Lindemann Mental Health Center, Boston, MA.
Amico
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Dreyfuss
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Ciraulo
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D000328:Adult; D001294:Attitude to Health; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D014282:Trihexyphenidyl / Q000627:therapeutic use*
D010919:Placebos; D014282:Trihexyphenidyl