title: Biochemical changes following parathyroidectomy.
abstract: Biochemical changes that had appeared after subtotal parathyroidectomy (PTx) in 26 patients with end-stage renal failure were observed. The volume of excised parathyroid glands was also measured. Serum calcium and inorganic phosphorus levels fell after PTx; only to rise in due course. Serum alkaline phosphatase levels rose after PTx, reaching a peak by the 14th post-operative day. These elevated levels returned to normal range at about three months after PTx. Strong correlation was noted among the degree of post-operative hypocalcemia, and increase in serum alkaline phosphatase, but not between absolute pre or post-operative alkaline phosphatase levels and changes in serum calcium or phosphorus concentrations. Nevertheless, significant correlation was seen between pre-PTx levels of alkaline phosphatase and its short-lived post-operative rise, indicating hastened osteoblastic activity.
authors.affiliation: Nephrology Clinic, University of Iowa College of Medicine, Des Moines.
authors.forename: P K
authors.initials: PK
authors.lastname: Chandran
authors.forename: T J
authors.initials: TJ
authors.lastname: Ulahannan
authors.forename: M
authors.initials: M
authors.lastname: Skiles
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010710:Phosphates / Q000097:blood; D012189:Retrospective Studies
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D000469:Alkaline Phosphatase; D002118:Calcium