title: Prediction of a putative fusion peptide in the S protein of hepatitis B virus.
abstract: Sequence analysis of the S protein of hepatitis B virus (HBV) reveals a stretch of 23 hydrophobic amino acids in the amino-terminal region which shows a high degree of similarity with known fusogenic peptides from other viruses. Additionally, this sequence also appears to be highly conserved within the hepadnavirus family. Taken together, the different criteria used in this work suggest fusogenic activity in the amino-terminal region of the S protein of the envelope of HBV.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Quimicas, Universidad Complutense, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Rodríguez-Crespo
authors.forename: J
authors.initials: J
authors.lastname: Gómez-Gutiérrez
authors.forename: M
authors.initials: M
authors.lastname: Nieto
authors.forename: D L
authors.initials: DL
authors.lastname: Peterson
authors.forename: F
authors.initials: F
authors.lastname: Gavilanes
mesh_terms: D000595:Amino Acid Sequence; D017124:Conserved Sequence; D006514:Hepatitis B Surface Antigens / Q000737:chemistry*; D006515:Hepatitis B virus / Q000737:chemistry*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014760:Viral Fusion Proteins / Q000737:chemistry*
chemical_list: D006514:Hepatitis B Surface Antigens; D014760:Viral Fusion Proteins