Two new polymorphisms in introns 2 and 3 of the human porphobilinogen deaminase gene.
Sequencing of the polymerase chain reaction amplified exon 2-4 fragment of the human porphobilinogen deaminase gene revealed a G/T polymorphism (I2G and I2T) in intron 2, and a G/A polymorphism (I3G and I3A) in intron 3 of the gene. The frequencies of these alleles are presented.
Daimon
M
M
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Morita
Y
Y
Yamatani
K
K
Igarashi
M
M
Fukase
N
N
Ohnuma
H
H
Sugiyama
K
K
Ogawa
A
A
Manaka
H
H
Tominaga
M
M
D000483:Alleles; D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11; D005787:Gene Frequency; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000235:genetics*; D007438:Introns; D007564:Japan; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D011163:Hydroxymethylbilane Synthase