title: Extracranial absorbed doses with Gamma Knife radiosurgery.
abstract: Radiosurgery is used with increasing frequency, not only for the treatment of cerebral arteriovenous malformations (AVMs), but also for the treatment of other well-defined lesions including acoustic neuromas, meningiomas, pituitary adenomas as well as solitary metastases. Although investigators have addressed dosimetric aspects of stereotactic radiosurgery in terms of target volume, little if any attention has been focused on the absorbed doses received at extracranial sites. Therefore, absorbed doses to the eye, thyroid, sternum and gonads were measured in 111 patients (100 adults and 11 children) using thermoluminescent dosimetry (TLDs). For the 100 adults, the average maximum target absorbed dose was 35 +/- 8 Gy. The measured absorbed dose in selected organs of adults from Gamma Knife radiosurgery using one or more isocenters was 9 +/- 8 cGy for the eye, 15 +/- 7 cGy for the thyroid, 20 +/- 10 cGy for the sternum and 3 +/- 2 cGy for the gonads. The absorbed doses received by the children (13 years and younger) was similar with the exception of a marked increase in gonadal dose. The use of multiple isocenters is associated with higher absorbed doses to extracranial sites.
authors.affiliation: Lars Leksell Center for Radiosurgery, University of Virginia Health Sciences Center, Charlottesville.
authors.forename: H W
authors.initials: HW
authors.lastname: Berk
authors.forename: J M
authors.initials: JM
authors.lastname: Larner
authors.forename: C
authors.initials: C
authors.lastname: Spaulding
authors.forename: S K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: M R
authors.initials: MR
authors.lastname: Scott
authors.forename: L
authors.initials: L
authors.lastname: Steiner
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery*; D002648:Child; D005123:Eye / Q000528:radiation effects; D005260:Female; D005836:Genitalia, Female / Q000528:radiation effects; D005837:Genitalia, Male / Q000528:radiation effects; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008297:Male; D008953:Models, Anatomic; D011829:Radiation Dosage; D016634:Radiosurgery / Q000295:instrumentation*; D012542:Scattering, Radiation; D013249:Sternum / Q000528:radiation effects; D013819:Thermoluminescent Dosimetry / Q000295:instrumentation*; D013961:Thyroid Gland / Q000528:radiation effects