Simple, rapid and simultaneous measurement of eight different types of carbamate pesticides in serum using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
We have developed a method for simultaneous analysis of methylcarbamate pesticides in serum with an acute pesticide intoxication. This is performed by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Rapid detection of eight types of methylcarbamate pesticide can be achieved with this method, it only requires an extremely simple pre-treatment of the sample. The specificity of this method is equal to that of gas chromatography-mass spectrometry, and it satisfies the clinical requirements for detection sensitivity and specificity. Although some problems with this analytical method remain to be solved, we consider it to be superior to any other analytical method previously reported.
Kawasaki
S
S
Department of Laboratory Medicine, Saga Medical School Hospital, Japan.
Nagumo
F
F
Ueda
H
H
Tajima
Y
Y
Sano
M
M
Tadano
J
J
D000085:Acetates; D019342:Acetic Acid; D002254:Carbonates / Q000097:blood* / Q000506:poisoning; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D013058:Mass Spectrometry; D010575:Pesticides / Q000097:blood* / Q000506:poisoning
D000085:Acetates; D002254:Carbonates; D010575:Pesticides; D019342:Acetic Acid; C018824:ammonium acetate