title: Application of topical lomefloxacin against experimental Pseudomonas endophthalmitis in rabbits.
abstract: Lomefloxacin is a new quinolone compound with a broad antibacterial spectrum and excellent penetration into the aqueous humor by topical application. Therefore, an experimental study was done to evaluate the efficacy of topical lomefloxacin against experimental endophthalmitis with Pseudomonas aeruginosa. Lomefloxacin eye drops were instilled six times a day onto infected rabbit eyes and gentamicin, sulbenicillin and saline were also tested comparatively in the same manner as lomefloxacin. Clinical observation for 1 week and counting viable pseudomonas cell numbers in the anterior chamber were done. Among all topical eye drops tested, lomefloxacin was shown to be most effective in lowering clinical scores and viable cell numbers in the anterior chamber. In conclusion, lomefloxacin is expected to be a useful ophthalmic solution in the treatment of pseudomonal endophthalmitis.
authors.affiliation: Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hatano
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Shia
authors.forename: W
authors.initials: W
authors.lastname: Liping
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects / Q000382:microbiology; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D015169:Colony Count, Microbial; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D024841:Fluoroquinolones; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000254:growth & development; D015363:Quinolones / Q000008:administration & dosage* / Q000627:therapeutic use; D011817:Rabbits; D013408:Sulbenicillin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D005839:Gentamicins; D009883:Ophthalmic Solutions; D015363:Quinolones; C053091:lomefloxacin; D013408:Sulbenicillin