Spontaneous regression in adult T-cell leukemia/lymphoma.
BACKGROUND
Spontaneous regression of adult T-cell leukemia/lymphoma (ATL) is considered to be extremely unusual. Of the 82 patients with ATL who the authors saw between 1981 and 1991, spontaneous regression occurred in 3 (3.7%), 2 of whom were previously untreated and one who had been previously treated. Surgical excisional biopsy triggered the spontaneous regression in these patients.


METHODS
In two of these patients with spontaneous regression, gene analysis studies of human T-cell leukemia virus type I (HTLV-I) proviral DNA, and T-cell receptor (TCR) were carried out by Southern blot analysis in lymph node cells or peripheral lymphocytes before regression and after recurrence.


RESULTS
One patient exhibited monoclonal integration of HTLV-I proviral DNA and the rearranged band of the TCR-beta gene at the same positions both before regression and after recurrence. The other patient showed them at the different positions before regression and after recurrence.


CONCLUSIONS
The authors' studies indicated heterogeneity in ATL patients with spontaneous regression. Temporary spontaneous regression could occur in typical ATL and might be associated with a longer survival time than that for prototypic ATL.
Shimamoto
Y
Y
Department of Internal Medicine, Saga Medical School, Japan.
Kikuchi
M
M
Funai
N
N
Suga
K
K
Matsuzaki
M
M
Yamaguchi
M
M
D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D015480:Deltaretrovirus Antibodies / Q000032:analysis; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics
D004273:DNA, Neoplasm; D004279:DNA, Viral; D015480:Deltaretrovirus Antibodies; D016693:Receptors, Antigen, T-Cell, alpha-beta