[The infectiousness of 18- to 20-kd proteins isolated from the brain of people who have died from amyotrophic leukospongiosis].
Specific globular structures, 10-12 nm in diameter, having a high resistance to various physicochemical factors and infectivity have been isolated for the first time from the brain of 2 patients, who died of amyotrophic leukospongiosis (AL). It has been shown that these globules contain infectious major protease-resistant protein with a molecular weight of about 18-20 kD. The findings indicate the unique nature of a disease and they open new aspects of AL etiopathogenesis.
Poleshchuk
N N
NN
Kapitulets
S P
SP
Kapitulets
N N
NN
Kvacheva
E B
EB
Eremin
V F
VF
Votiakov
V P
VP
D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000382:microbiology*; D002540:Cerebral Cortex / Q000382:microbiology*; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D004591:Electrophoresis, Polyacrylamide Gel; D006168:Guinea Pigs; D006801:Humans; D008854:Microscopy, Electron; D008970:Molecular Weight; D017096:Prion Diseases / Q000209:etiology / Q000382:microbiology*; D011328:Prions / Q000032:analysis / Q000302:isolation & purification / Q000472:pathogenicity* / Q000648:ultrastructure; D012692:Serial Passage; D012897:Slow Virus Diseases / Q000209:etiology / Q000382:microbiology*
D011328:Prions
Infektsionnost' belkov 18--20 kd, vydelennykh iz mozga liudeĭ, umershikh ot amiotroficheskogo leĭkospongioza.