title: Effects of positive acceleration on atrial natriuretic peptide in humans.
abstract: To study the effects of positive acceleration on the plasma atrial natriuretic peptide (ANP) and renin concentration (PRC), students of the Korean Air Force Academy and pilots were exposed to +6 Gz for 30 s in a human centrifuge without anti-G suits. An acceleration to +6 Gz caused a significant increase (p < 0.01) in the heart rate of both the student and pilot groups. We performed blood collection within 2 min after terminating centrifugation. Systolic blood pressure was increased significantly (p < 0.01), and heart rates were elevated and did not return to control levels by 2 min after centrifugation. Plasma ANP decreased significantly in both groups (p < 0.05). The difference in the percentage of ANP decrement was not significant between student and pilot groups. PRC increased significantly (p < 0.05) in both groups. This study demonstrated that high +Gz exposure in man caused a significant reduction of plasma ANP concentration, although PRC, heart rate, and blood pressure increase.
authors.affiliation: Aeromedical Training Center, ROKAF, Cheungwon, Republic of Korea.
authors.forename: J K
authors.initials: JK
authors.lastname: Park
authors.forename: K H
authors.initials: KH
authors.lastname: Seul
authors.forename: B O
authors.initials: BO
authors.lastname: Park
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: K W
authors.initials: KW
authors.lastname: Cho
mesh_terms: D000054:Acceleration; D000328:Adult; D000337:Aerospace Medicine; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D006112:Gravitation; D006339:Heart Rate; D006801:Humans; D012083:Renin / Q000097:blood
chemical_list: D009320:Atrial Natriuretic Factor; D012083:Renin