title: [Concept of causal implication in unexpected effects of drugs. An example of cardiotoxicity caused by anthracyclines].
abstract: Over the last 30 years, considerable progress have been made in developing methodologies to analyze unwanted drug effects. The aim of this study is to explain the French method utilized to impute the side effects of a drug. An example of anthracycline cardiotoxicity will be discussed.
authors.affiliation: Unité de Pharmacologie Clinique, Hôpital Necker-Enfants Malades, Paris.
authors.forename: O
authors.initials: O
authors.lastname: Ganry
authors.forename: X
authors.initials: X
authors.lastname: Tabone
authors.forename: C
authors.initials: C
authors.lastname: Vauzelle-Gardier
authors.forename: P
authors.initials: P
authors.lastname: Meyer
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D002303:Cardiac Output, Low / Q000139:chemically induced*; D004317:Doxorubicin / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008722:Methods; D008875:Middle Aged
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin
vernacular_title: Notion d'imputabilité des effets inattendus des médicaments. Exemple d'un cas de cardiotoxicité aux anthracyclines.