title: [The relation between Behçet's disease and interleukin-1 beta production].
abstract: Interleukin-1 beta (IL-1 beta) is an inflammatory cytokine. We measured its production in 21 Behçet's disease patients, 4 healthy controls, and 4 sarcoidosis patients, by enzyme-linked immunosorbent assay (ELISA) after stimulation with lipopolysaccharide from peripheral blood monocytes. IL-1 beta production of the posterior segment type was significantly greater (p < 0.001) than in healthy controls, sarcoidosis patients, and anterior segment type. In all posterior segment type cases, IL-1 beta production in the active period was greater than in the remission period. IL-1 beta production is considered to be related to posterior segment type attacks of Behçet's disease.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Tachinami
authors.forename: M
authors.initials: M
authors.lastname: Ishiguro
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology
chemical_list: D007375:Interleukin-1