title: Time course of action and endotracheal intubating conditions of Org 9487, a new short-acting steroidal muscle relaxant; a comparison with succinylcholine.
abstract: In a randomized study, we evaluated lag time (time from the end of injection of muscle relaxant until the first depression of the train-of-four response [TOF]), onset time (time from the end of injection of muscle relaxant until the maximum depression of the first twitch of the TOF [T1]), neuromuscular block, and endotracheal intubating conditions at 1 min after 1 mg/kg succinylcholine (n = 15) and 1.5 mg/kg Org 9487 (n = 30). Two minutes after administration of Org 9487, 15 of the 30 patients received neostigmine for reversal. Recovery of neuromuscular block after succinylcholine, Org 9487 without and Org 9487 with neostigmine were compared using the time until T1 was 90% for the succinylcholine group, and the time until TOF was 70% for the Org 9487 groups. Neuromuscular transmission was monitored mechanomyographically. Onset time was similar (67 [20] and 83 [38] s for succinylcholine and Org 9487, respectively) and endotracheal intubating conditions were also similar after both muscle relaxants. Times until clinically sufficient recovery of neuromuscular block induced by succinylcholine (time until T1 = 90%: 10.6 [3.3] min) and Org 9487 with neostigmine (time until TOF = 70%: 11.6 [1.4] min) were not different. In contrast, in the Org 9487 without neostigmine group, more time was required until complete recovery (24.1 [6.2] min) (P < 0.05). In conclusion, ORg 9487 is a muscle relaxant suitable for endotracheal intubation and short-lasting interventions.
authors.affiliation: Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Wierda
authors.forename: L
authors.initials: L
authors.lastname: van den Broek
authors.forename: J H
authors.initials: JH
authors.lastname: Proost
authors.forename: B W
authors.initials: BW
authors.lastname: Verbaan
authors.forename: P J
authors.initials: PJ
authors.lastname: Hennis
mesh_terms: D000328:Adult; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D011930:Reaction Time; D013390:Succinylcholine / Q000494:pharmacology*; D009435:Synaptic Transmission; D013997:Time Factors; D014673:Vecuronium Bromide / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; D014673:Vecuronium Bromide; C082938:rapacuronium; D013390:Succinylcholine