title: Intravitreal penetration of oral pefloxacin in humans.
abstract: We measured vitreous and serum levels of pefloxacin after oral administration. Twenty patients with retinal detachments undergoing vitrectomy were recruited into this study. Each patient received 400 mg pefloxacin orally 1 to 12 hours before vitrectomy. Vitreous fluid (0.1 mL) was aspirated at surgery. Vitreous levels of pefloxacin were determined by high-performance liquid chromatography. Six hours after oral administration, an average level of 1.37 microgram/mL of pefloxacin was measured in the vitreous samples. These levels were well above the minimum inhibitory concentration (MIC) for most organisms termed sensitive to pefloxacin. Oral administration of pefloxacin may play an important role in the prevention or management of endophthalmitis.
authors.affiliation: Ophthalmology Department, Cerrahpasa Medical School, Istanbul University, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Oncel
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015366:Pefloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000601:surgery; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D015366:Pefloxacin