Chemoprophylaxis for pulmonary aspergillosis during intensive chemotherapy.
Three children who developed pulmonary aspergillosis while being treated for leukaemia or non-Hodgkin's lymphoma. Each child continued with intensive myelosuppressive chemotherapy regimens during the infection and each was successfully treated with antifungal prophylaxis based on itraconazole by mouth. Amphotericin B was also given during periods of severe neutropenia. No reactivation of the fungal infection was seen.
Cowie
F
F
Children's Department, Royal Marsden Hospital, Sutton, Surrey.
Meller
S T
ST
Cushing
P
P
Pinkerton
R
R
D000666:Amphotericin B / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000517:prevention & control*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008168:Lung / Q000000981:diagnostic imaging; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000517:prevention & control*; D008297:Male; D009503:Neutropenia / Q000139:chemically induced; D009894:Opportunistic Infections / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011859:Radiography
D000970:Antineoplastic Agents; D017964:Itraconazole; D000666:Amphotericin B