Use of X-linked clonal analysis in acute promyelocytic leukemia.
X-linked clonal analysis (XLCA) either using Glucose-6-phosphate dehydrogenase (G-6-P-D) polymorphisms or restriction fragment length polymorphisms (RFLP) and methylation analysis has provided considerable understanding of haematologic malignancy. Acute Promyelocytic Leukemia (APL) is characterized by a unique cytogenetic translocation t(15;17), frequent achievement of remission without a preceding phase of marrow hypocellularity after induction chemotherapy and a high rate of clinical response to all-trans retinoic acid (ATRA). In limited studies XLCA has provided insight into the pathogenesis and mechanism of drug action in this disease.
Taylor
K M
KM
Department of Haematology, Mater Misericordiae Hospitals, Brisbane, Australia.
Rodwell
R L
RL
Elliott
S L
SL
Taylor
D L
DL
D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D014212:Tretinoin / Q000627:therapeutic use; D014410:Tumor Stem Cell Assay; D014960:X Chromosome
D014212:Tretinoin