[Natural history of non-alcoholic chronic pancreatitis. Study of 37 cases and comparison with 319 cases of alcoholic chronic pancreatitis].
We studied the etiology, complications, need for surgical treatment and survival in patients with non-alcoholic chronic pancreatitis (n = 37, including 5 familial, 2 postradiation and 30 idiopathic cases of pancreatitis) and with alcoholic chronic pancreatitis (n = 319). The median follow-up was 6 years. There was a higher frequency of onset of the disease in the fourth decade in alcoholic patients and a more regular pattern with a peak in the third decade in the non-alcoholic patients. The comparison between the two groups showed, in non-alcoholic patients: a lower M/F ratio (non-alcoholics: 1, alcoholics: 9; P < 0.0001), less smokers (P < 0.0001), a lower cumulative probability for development of pancreatic calcification (P < 0.02), insulin-dependent diabetes mellitus (P < 0.02) and pseudocysts (P < 0.01). Frequency and type of surgery were not different in the 2 groups. The observed survival of non-alcoholic patients was better than the observed survival in alcoholic patients and than the expected survival in a matched French population.


CONCLUSIONS
in this study, non-alcoholic chronic pancreatitis accounted for 10.4% of the disease; the comparison to alcoholic chronic pancreatitis shows that it is the same, however less evolutive, disease. Chronic pancreatitis by itself has no major influence on vital prognosis.
Dancour
A
A
Service de Gastroentérologie, Hôpital Beaujon, Clichy.
Lévy
P
P
Milan
C
C
Bernades
P
P
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D002114:Calcinosis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010192:Pancreatic Pseudocyst / Q000209:etiology*; D010195:Pancreatitis / Q000209:etiology* / Q000378:metabolism / Q000401:mortality / Q000601:surgery; D012307:Risk Factors
D000431:Ethanol
Histoire naturelle de la pancréatite chronique non alcoolique. Etude de 37 cas et comparaison avec 319 cas de pancréatite chronique alcoolique.