Effect of ketoprofen on Escherichia coli heat-stable enterotoxin-induced diarrhea of calves.
To evaluate the effect of ketoprofen on fecal output during secretory diarrhea, 16 calves were given approximately 200 micrograms of heat-stable Escherichia coli enterotoxin by suckling on 2 occasions. On one day, treatment was not administered. On the other day, either 3 mg of ketoprofen/kg of body weight (n = 8) or 6 mg of ketoprofen/kg (n = 8) was administered 1 hour before and 3 hours after administration of enterotoxin. Fecal output was no different after 8 or 24 hours from calves given 3 mg/kg, but fecal output was less at 8 hours and 24 hours for calves given 6 mg/kg (P = 0.0588), compared with the control day.
Roussel
A J
AJ
Department of Large Animal Medicine and Surgery, Texas A&M University, College Station 77843.
Dodson
S L
SL
Brumbaugh
G W
GW
Sriranganathan
N
N
Overbay
T D
TD
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D002417:Cattle; D003967:Diarrhea / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004768:Enterotoxins / Q000633:toxicity*; D029968:Escherichia coli Proteins; D005243:Feces; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male
D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli); D007660:Ketoprofen