title: [Cytokines and immune response].
abstract: This review paper briefly describes the principal cytokines involved in immune response, and in particular their role in some of its key-steps: antigen presentation; activation, proliferation and differentiation of CD4+ T cell subsets; antibody response by B cells; manifestations of hypersensitivity. The role played by cytokines in cytotoxic T cell (CTL) differentiation and in T cell-mediated suppression phenomena is also discussed. It seems that the auxiliary CD4+ memory cells secrete either IL-2 and interferon gamma (Th1) or IL-4 and IL-5 (Th2). It has recently been suggested that cytotoxic/suppressor CD8+ cells can also be divided into cells that secrete interferon gamma and no IL-4 (CTL) and cells that secrete IL-4 and IL-5 (suppressor T cells). The reciprocal regulatory effects of these cell populations through these interleukins is also discussed.
authors.affiliation: INSERM U28, hôpital Broussais, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Pelletier
authors.forename: B
authors.initials: B
authors.lastname: Bellon
authors.forename: P
authors.initials: P
authors.lastname: Druet
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology*; D007378:Interleukins / Q000276:immunology
chemical_list: D016207:Cytokines; D007378:Interleukins
vernacular_title: Cytokines et réponse immune.