Early hematologic changes in rhesus macaques (Macaca mulatta) infected with pathogenic and nonpathogenic isolates of SIVmac.
Early hematologic changes were studied over a 14 day period in three groups of six rhesus macaques intravenously infected with pathogenic and nonpathogenic isolates of SIVmac. Abnormalities in blood included a mild blood loss anemia, sporadic lymphopenia, and variable CD4+ and CD8+ T lymphocyte numbers. Prominent bone marrow findings in macaques inoculated with pathogenic uncloned SIVmac and molecularly cloned pathogenic SIVmac-239 were hypercellularity, myeloid and megakaryocytic hyperplasia, and lymphoid aggregates. Infrequent mild morphologic abnormalities were present in macaques infected with a nonpathogenic molecular clone, SIVmac-1A11.
Mandell
C P
CP
Department of Clinical Pathology, School of Veterinary Medicine, University of California, Davis 95616.
Jain
N C
NC
Miller
C J
CJ
Marthas
M
M
Dandekar
S
S
D000740:Anemia / Q000209:etiology; D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens; D003001:Cloning, Molecular; D008231:Lymphopenia / Q000209:etiology; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000209:etiology / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000472:pathogenicity*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013997:Time Factors
D016827:CD8 Antigens