Differential efficacies of dopamine D1 receptor agonists for stimulating adenylyl cyclase in squirrel monkey and rat.
Adenylyl cyclase activity was stimulated by dopamine to approximately 200% over basal activity in both squirrel monkey caudate and rat caudate-putamen. The selective dopamine D1 receptor agonists SKF 82958, A68930, dihydrexidine, CY 208-243, and SKF 75670 each produced similar maximal stimulation across the two species. SKF 38393, SKF 81297, and 6-Br-APB, however, each had higher efficacy in rat than in monkey. These results suggest differences in dopamine D1 receptors in the two species.
Izenwasser
S
S
Psychobiology Section, NIDA Addiction Research Center, Baltimore, MD.
Katz
J L
JL
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology; D004298:Dopamine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D011699:Putamen / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D012453:Saimiri; D013045:Species Specificity; D013268:Stimulation, Chemical
D015259:Dopamine Agents; D017447:Receptors, Dopamine D1; D000262:Adenylyl Cyclases; D004298:Dopamine