[Evaluation of the gonadoliberin and niftolid tests in the diagnosis of male hypogonadism].
Comparative analysis with an antiandrogen niftolid and synthetic GnRH was carried out in 22 normal subjects, 14 patients with primary and 20 ones with secondary hypogonadism, and in 5 patients with clinical signs of gonadal insufficiency and obscure diagnosis in order to elucidate the pituitary gonadotropin reserves. Blood plasma and daily urine gonadotropin levels were measured. Changed gonadotropin excretion under the effect of niftolid in health and hypogonadism was in line with changed gonadotropin level in the blood after RF administration, this indicating a similar informative value of both tests for the differential diagnosis of various hypogonadism forms. In the first case measurements of blood gonadotropin were more informative, in the second daily urine analysis. Niftolid test, noninvasive and readily available, is recommended as an alternative test with RF administration.
Reznikov
A G
AG
Varga
S V
SV
Demchenko
V N
VN
Boiarskaia
O Ia
OIa
D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005485:Flutamide; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000652:urine; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis*; D007986:Luteinizing Hormone / Q000097:blood / Q000652:urine; D008297:Male; D011863:Radioimmunoassay
D007987:Gonadotropin-Releasing Hormone; D005485:Flutamide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Otsenka prob s gonadoliberinom i niftolidom v diagnostike muzhskogo gipogonadizma.