C-erbB-2/HER-2 protein in human intracranial tumours.
Normal and neoplastic human intracranial tissues were examined by immunohistochemistry for c-erbB-2/HER-2 protein expression. Positive staining was observed in 1/41 gliomas, 1/2 medulloblastomas, 1/1 germinoma, 11/16 meningiomas, 1/3 anaplastic meningiomas and 11/19 metastatic brain carcinomas. No positive staining was observed in normal intracranial tissues. Thus, the expression of the c-erbB-2/HER-2 protein is limited to intracranial tumour tissues, principally meningiomas and metastatic carcinomas to the brain.
Torp
S H
SH
Institute of Cancer Research, University of Trondheim, Norway.
Helseth
E
E
Unsgaard
G
G
Dalen
A
A
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000737:chemistry* / Q000556:secondary; D002675:Child, Preschool; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000737:chemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D018719:Erb-b2 Receptor Tyrosine Kinases
D066246:ErbB Receptors; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases