title: Experiments on an early protection against foot-and-mouth disease virus.
abstract: The influence of the peptide diacetylsplenopentin (SP5) on an early protection of guinea pigs against foot-and-mouth disease (FMD) was investigated. 80% protection was achieved if SP5 was applied in a dose of 2 mg one day before challenge with FMD virus (FMDV) type O1 Lausanne strain. In comparison with this a conventional commercial adsorbate vaccine protected guinea pigs about 7 days after vaccination. An earlier protection can be obtained in general by vaccination with a higher content of the immunogen. A tenfold increase of the 146 S particle dose in a conventional oil adjuvanted FMDV vaccine protected pigs about 2 days earlier as observed after inoculating a "normal" vaccine (about 11 days).
authors.affiliation: KAI e.v./Institut für Medizinische Mikrobiologie, E.-M.-Arndt-Universität, Greifswald, Germany.
authors.forename: H T
authors.initials: HT
authors.lastname: Liebermann
authors.forename: G
authors.initials: G
authors.lastname: Thalmann
authors.forename: T
authors.initials: T
authors.lastname: Bartels
authors.forename: A
authors.initials: A
authors.lastname: Nöckler
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D005537:Aphthovirus / Q000276:immunology*; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D006168:Guinea Pigs; D010446:Peptide Fragments / Q000276:immunology*; D013946:Thymopoietins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D010446:Peptide Fragments; D013946:Thymopoietins; D014765:Viral Vaccines; C041898:splenopentin