title: Malignant histiocytosis with multiple skin lesions in a dog.
abstract: A 7-year-old male Yorkshire terrier was examined for multiple plaques and nodules on the skin. The clinical, cytological and histopathological features indicated a malignant histiocytosis. Cytoreductive chemotherapy produced moderate clinical improvement, but died at day 90 after the first admission. Pathological examination revealed the neoplastic histiocytes in the skin as well as in the myocardium and skeletal muscles.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Uno
authors.forename: Y
authors.initials: Y
authors.lastname: Momoi
authors.forename: T
authors.initials: T
authors.lastname: Watari
authors.forename: R
authors.initials: R
authors.lastname: Goitsuka
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: T
authors.initials: T
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: N
authors.initials: N
authors.lastname: Goto
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004283:Dog Diseases; D004285:Dogs; D006338:Heart Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary; D054747:Histiocytic Sarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D009132:Muscles / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D014750:Vincristine; D003606:Dacarbazine; D003520:Cyclophosphamide; D011239:Prednisolone; D008942:Mitoxantrone