Site-specific recombinases: tools for genome engineering.
Site-specific recombinases from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.
Kilby
N J
NJ
Institute of Biotechnology, University of Cambridge, UK.
Snaith
M R
MR
Murray
J A
JA
D000818:Animals; D001483:Base Sequence; D004254:DNA Nucleotidyltransferases / Q000378:metabolism*; D005818:Genetic Engineering; D016678:Genome; D008969:Molecular Sequence Data; D013379:Substrate Specificity
D004254:DNA Nucleotidyltransferases