title: Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria.
abstract: Anaerobic incubation of strychnine N-oxide with human intestinal bacteria resulted in its transformation to strychnine and 16-hydroxystrychnine. Similarly, brucine N-oxide was transformed to brucine and 16-hydroxybrucine.
authors.affiliation: Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University.
authors.forename: S
authors.initials: S
authors.lastname: el-Mekkawy
authors.forename: M R
authors.initials: MR
authors.lastname: Meselhy
authors.forename: Y
authors.initials: Y
authors.lastname: Kawata
authors.forename: S
authors.initials: S
authors.lastname: Kadota
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Namba
mesh_terms: D001421:Bacteria, Anaerobic / Q000378:metabolism*; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D015394:Molecular Structure; D013331:Strychnine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: D003497:Cyclic N-Oxides; C083067:brucine N-oxide; C083068:strychnine N-oxide; D013331:Strychnine