title: Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin.
abstract: Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration.
authors.affiliation: Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
authors.forename: N D
authors.initials: ND
authors.lastname: Brown
authors.forename: D L
authors.initials: DL
authors.lastname: Butler
authors.forename: P K
authors.initials: PK
authors.lastname: Chiang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000595:Amino Acid Sequence; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D000087522:Cyanobacteria Toxins; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008387:Marine Toxins / Q000494:pharmacology; D052998:Microcystins; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D016305:Thymopentin / Q000737:chemistry* / Q000494:pharmacology; D014326:Tropanes; D047392:beta-Cyclodextrins
chemical_list: D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D003505:Cyclodextrins; D008387:Marine Toxins; D052998:Microcystins; D014326:Tropanes; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C509783:anatoxin a; D016305:Thymopentin