Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde.
A cDNA clone of the E3 isozyme of human liver aldehyde dehydrogenase consisting of a 1320-base pair (bp) coding region and a 180-bp non-coding region at the 3' end was used for chromosomal localization of the E3 gene. Using a panel of human/hamster somatic cell hybrids we have localized, the gene coding for the E3 isozyme to human chromosome 1.
McPherson
J D
JD
Department of Biological Chemistry, University of California, Irvine 92717.
Wasmuth
J J
JJ
Kurys
G
G
Pietruszko
R
R
D000444:Aldehyde Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D015139:Blotting, Southern; D016466:CHO Cells; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000201:enzymology
D000447:Aldehydes; D007527:Isoenzymes; C006509:4-aminobutyraldehyde; D000444:Aldehyde Dehydrogenase