title: [UV irradiation of the cerebrospinal fluid in the treatment of patients with disseminated sclerosis].
abstract: Cerebrospinal fluid (SF) in the quantity 5-7 ml from 26 multiple sclerosis patients was exposed to UV radiation with subsequent reinfusion. The assessment of clinical symptoms and immunological indices 7 days later showed that positive results (6 scores by Sipe scale) were achieved in 14 patients with cell abundance in the SF. The improvement was indicated by positive trends in pelvic functions, sensory and coordination disorders, normalization of the blood immunological picture. The responders exhibited elevated SF levels of B-lymphocytes, phagocytosing cells and IgM concentrations. High levels of IgG registered in 58% of the patients did not change. The only side effect was represented by short-term postpuncture syndrome in 4 patients with arterial hypotension. In 12 patients with progressive sclerosis the treatment was ineffective.
authors.forename: N A
authors.initials: NA
authors.lastname: Totolian
authors.forename: I M
authors.initials: IM
authors.lastname: Barbas
authors.forename: A A
authors.initials: AA
authors.lastname: Skoromets
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Smirnov
authors.forename: A A
authors.initials: AA
authors.lastname: Totolian
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000528:radiation effects; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000528:radiation effects*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology / Q000532:radiotherapy*; D012074:Remission Induction; D014467:Ultraviolet Therapy / Q000295:instrumentation / Q000379:methods
vernacular_title: UF-obluchenie tserebrospinal'noĭ zhidkosti v lechenii bol'nykh rasseiannym sklerozom.