Effect of ceruletide on epileptogenesis in amygdaloid kindled rats.
The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 micrograms/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 micrograms/kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.
Yamamoto
Y
Y
Department of Physiology, Kagawa Medical School, Japan.
Itano
T
T
Miyamoto
O
O
Tokuda
M
M
Matsui
H
H
Janjua
N A
NA
Suwaki
H
H
Okada
Y
Y
Negi
T
T
Murakami
T H
TH
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D004558:Electric Stimulation; D004827:Epilepsy / Q000517:prevention & control*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002108:Ceruletide