Influence of nosocomial infection on mortality rate in an intensive care unit.
OBJECTIVE
To assess the impact of nosocomial infection on the mortality rate in an intensive care unit (ICU).


METHODS
Prospective cohort study.


METHODS
The ICU of the University of Granada Hospital in Spain.


METHODS
All patients (n = 279) admitted for > or = 48 hrs at the ICU between December 1986 and April 1988.


METHODS
Nosocomial infections were diagnosed according to Study on the Efficacy of Nosocomial Infection Control (SENIC) and Centers for Disease Control criteria. Patient severity on admission (using Acute Physiology and Chronic Health Evaluation (APACHE II) and Therapeutic Intensity Scoring Systems were also used.


RESULTS
Mortality risk was 2.48 times higher in patients with a nosocomial infection than in noninfected patients. Relative risk of mortality in nosocomially infected patients was higher in young and less severely ill patients, in those patients with respiratory diseases, and in those patients with longer ICU stays. Logistic stepwise regression analysis, adjusting for several confounding factors (affected organ system, APACHE II score, and therapeutic intensity), showed that the risk of death in nosocomially infected patients was 2.1 times greater (95% confidence interval = 1.0 to 4.41) than in patients without such infection.


CONCLUSIONS
Nosocomial infection increases the risk of death. The effect is stronger in younger and less severely ill patients.
Bueno-Cavanillas
A
A
Department of Preventive Medicine, University of Granada Hospital, Spain.
Delgado-Rodríguez
M
M
López-Luque
A
A
Schaffino-Cano
S
S
Gálvez-Vargas
R
R
D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D003428:Cross Infection / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013030:Spain