title: Influence of humate on calcium hydroxyapatite implants.
abstract: Implanted bovine apatite is highly osteoconductive, since it serves the host tissue as a "guide-line" for the deposition of newly developing bone tissue. It is well tolerated, but it showed no signs of being resorbed during the course of the experiment. Previous impregnation of the bovine hydroxyapatite with a low molecular humate substance obviously encourages its resorption. This is most easily explained by the known ability of humate to induce the activation of leucocytes. The occasional over-resorption of the apatite is dependent (1) upon the preparation of the implant (granulate) and (2) the local concentration of the humate. Future research is being directed towards the production of a satisfactorily usable form of humate and apatite and the investigation of its HIV blocking action on heterologous cancellous bone.
authors.affiliation: Department of Surgery (Traumatology), University Hospital, Freiburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Schlickewei
authors.forename: U N
authors.initials: UN
authors.lastname: Riede
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: W
authors.initials: W
authors.lastname: Ziechmann
authors.forename: E H
authors.initials: EH
authors.lastname: Kuner
authors.forename: B
authors.initials: B
authors.lastname: Seubert
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D016025:Bone Transplantation / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002417:Cattle; D017886:Durapatite; D006812:Humic Substances; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000502:physiology*; D019736:Prostheses and Implants; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D006812:Humic Substances; D017886:Durapatite