title: The SBASE domain library: a collection of annotated protein segments.
abstract: SBASE is a database of annotated protein domain sequences representing various structural, functional, ligand binding and topogenic segments of proteins. The current release of SBASE contains 27,211 entries which are provided with standardized names in order to facilitate retrieval. SBASE is cross-referenced to the major protein and nucleic acid databanks as well as to the PROSITE catalog of protein sequence patterns [Bairoch, A. (1992) Nucleic Acids Res., 20, Suppl., 2013-2118]. SBASE can be used to establish domain homologies through database search using programs such as FASTA [Lipman and Pearson (1985) Science, 227, 1436-1441], FASTDB [Brutlag et al. (1990) Comp. Appl. Biosci., 6, 237-245] or BLAST3 [Altschul and Lipman (1990) Proc. Natl. Acad. Sci. USA, 87, 5509-5513], which is especially useful in the case of loosely defined domain types for which efficient consensus patterns cannot be established. The use of SBASE is illustrated on the DNA binding protein Brain-4. The database and a set of search and retrieval tools are freely available on request to the authors or by anonymous 'ftp' file transfer from < ftp.icgeb.trieste.it >.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology, Area Science Park, Trieste, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pongor
authors.forename: V
authors.initials: V
authors.lastname: Skerl
authors.forename: M
authors.initials: M
authors.lastname: Cserzö
authors.forename: Z
authors.initials: Z
authors.lastname: Hátsági
authors.forename: G
authors.initials: G
authors.lastname: Simon
authors.forename: V
authors.initials: V
authors.lastname: Bevilacqua
mesh_terms: D000595:Amino Acid Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry; D016208:Databases, Factual; D005801:Genes, Homeobox; D016247:Information Storage and Retrieval; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D017385:Sequence Homology; D012984:Software
chemical_list: D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D011506:Proteins