[Frequency of chromosome aberrations induced by hypoxia in cells of the rat bone marrow differing in resistance to this trait].
The frequency of hypoxia induced chromosome aberrations in bone marrow cells of rats was researched. According to the resistance to acute hypoxia 2 groups from the population of the laboratory animals were singled out. One of the groups is low resistant animals capable of being at "the height" 11 thousand metres during 5 minutes, the other group is high resistant animals capable of being in the state of acute hypoxia during 25 minutes and even longer. It is shown that acute hypoxia causes chromosome aberrations in both the groups with the same frequency, whereas the following chronic hypoxia (being at "the height" of 8250 m during 3 hours daily for 9 days) induces a truly larger quantity of chromosome aberrations in high resistant rats as compared with low resistant rats.
Bykovskaia
N V
NV
Khaĭtsev
N V
NV
Shvartsman
P Ia
PIa
D000222:Adaptation, Physiological; D000818:Animals; D001854:Bone Marrow Cells; D015687:Cell Hypoxia / Q000235:genetics; D002869:Chromosome Aberrations / Q000502:physiology*; D008297:Male; D016296:Mutagenesis; D051381:Rats
Chastota khromosomnykh aberratsiĭ, indutsirovannykh gipoksieĭ v kletkakh kostnogo mozga krys razlichaiushchikhsia po ustoĭchivosti k étomu priznaku.