Effects of alpha helical CRF 9-41 on neurophysiological and autonomic patterns induced by CRF in the rabbit.
The EEGraphic, behavioural and autonomic effects related to the separated and simultaneous central administration of CRF and CRF antagonist (alpha-helical CRF 9-41) were evaluated in the rabbit. CRF produced a decrease of cortical EEG power spectrum, a biphasic effect on the heart rate, a hyperthermia and tachypnoea. 9-41 CRF significantly increased the EEG power spectrum, but it did not affect the autonomic parameters. The simultaneous administration of these peptides resulted in a significative and rapid inhibition of all the CRF effects. The intrinsic properties of 9-41 CRF on EEG and the interaction with CRF were discussed.
Marchioni
E
E
Istituto Neurologico C. Mondino, Università di Pavia.
Maurelli
M
M
Tartara
A
A
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007276:Injections, Intraventricular; D010446:Peptide Fragments / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D017433:Protein Structure, Secondary; D011817:Rabbits; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D012119:Respiration / Q000187:drug effects; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; D018019:Receptors, Corticotropin-Releasing Hormone; D003346:Corticotropin-Releasing Hormone; C045089:corticotropin releasing hormone (9-41)