Pretreatment with alfentanil reduces pain caused by propofol.
We have compared two groups (n = 22) of unpremedicated patients to determine if the pain caused by injection of propofol could be modified by alfentanil. In group I, alfentanil 1 mg was given as a bolus i.v. injection 15 s before administration of propofol i.v., while group II received saline. Propofol was given in 20-mg increments every 4 s. All injections were given through the same i.v. cannula on the dorsum of one hand. We found that alfentanil pretreatment reduced pain on injection of propofol (P = 0.001).
Fletcher
J E
JE
Department of Anaesthetics, Royal Hampshire County Hospital, Winchester.
Seavell
C R
CR
Bowen
D J
DJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D015760:Alfentanil / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011229:Preanesthetic Medication; D015742:Propofol / Q000009:adverse effects*; D013997:Time Factors
D015760:Alfentanil; D015742:Propofol