Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3.
Mucositis is a common, dose-limiting complication in patients receiving cancer chemotherapy, which appears to be a consequence of the rate of epithelial proliferation. The beta transforming growth factors have been shown to be negative regulators of epithelial cell proliferation. Here we show that transforming growth factor beta 3 administration reduced proliferation of oral epithelium in vitro and in vivo. Topical application of transforming growth factor beta 3 to the oral mucosa of the Syrian golden hamster prior to chemotherapy significantly reduced the incidence, severity, and duration of oral mucositis, reduced chemotherapy-associated weight loss, and increased survival.
Sonis
S T
ST
Division of Oral Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Lindquist
L
L
Van Vugt
A
A
Stewart
A A
AA
Stam
K
K
Qu
G Y
GY
Iwata
K K
KK
Haley
J D
JD
D000818:Animals; D016466:CHO Cells; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D004195:Disease Models, Animal; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005472:Fluorouracil / Q000009:adverse effects*; D008647:Mesocricetus; D008907:Mink; D009061:Mouth Mucosa / Q000166:cytology / Q000187:drug effects; D013280:Stomatitis / Q000139:chemically induced* / Q000517:prevention & control*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014456:Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control
D016212:Transforming Growth Factor beta; D004247:DNA; D005472:Fluorouracil