[The effect of calcium-regulating pharmacological preparations on the formation of a generator of pathologically enhanced excitation in the system of the dorsal horns of the spinal cord].
A model of spinal pain syndrome induced by a generator of abnormally increased excitation in the system of dorsal horns of the spinal cord with penicillin was used to test the calcium channel blockers OF5015 and nimotop, as well as calcium gluconate for their effects. The drugs were administered orally, intraperitoneally, intracisternally and applied to the spinal cord in combination with penicillin which was used to induce the pain syndrome. The action of the agents were compared with that of analgin. OF5015 given in a dose orally was shown to attenuate the pain syndrome to a greater extent than analgin. Nimotop and calcium gluconate given orally or intrasystematically failed to affect the pain syndrome. When applied to the spinal cord, all the drugs substantially attenuated the pain syndrome or prevented its development.
Danilov
E I
EI
Grafova
V N
VN
Reshetniak
V K
VK
D000208:Acute Disease; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002125:Calcium Gluconate / Q000627:therapeutic use*; D004177:Dipyrone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D009553:Nimodipine / Q000627:therapeutic use; D009930:Organic Chemicals; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010406:Penicillins; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects*
D002121:Calcium Channel Blockers; C086070:OF 5015; D009930:Organic Chemicals; D010406:Penicillins; D009553:Nimodipine; D004177:Dipyrone; D002125:Calcium Gluconate
Vliianie kal'tsiĭreguliruiushchikh farmakologicheskikh preparatov na obrazovanie generatora patologicheski usilennogo vozbuzhdeniia v sisteme dorsal'nykh rogov spinnogo mozga.