title: Preoperative plateletpheresis does not reduce blood loss during cardiac surgery.
abstract: Acute preoperative plateletpheresis has been reported to be effective in reducing blood loss and blood component transfusion while improving haematological profiles in patients undergoing open-heart surgery. However, in these studies, the concomitant use of cell saver techniques may have been responsible for the beneficial effects because they remove free haemoglobin and activated procoagulants and, therefore, could mask the deleterious effects of combined plateletpheresis and cardiopulmonary bypass (CPB). In the present study, 40 patients undergoing primary myocardial revascularization were randomly divided into two groups: a control group without plateletpheresis performed, and a second group in which preoperative platelet-rich plasma 10 ml.kg-1 (PRP group) was collected and later reinfused after reversal of heparin. Standardized surgery, anaesthesia and CPB without concomitant cell saver techniques were employed. In the PRP group, blood transfusion was reduced (1.5 +/- 1.3 vs 2.4 +/- 1.3 units, P < 0.05) but this was accompanied by lower postoperative haemoglobin concentrations. There were no differences in blood loss (992.6 +/- 327.4 vs 889.6 +/- 343.7 ml), fresh frozen plasma (2/19 vs 3/20 patients) or platelet requirements (1/19 vs 1/20 patients). Reinfusion of autologous PRP did not improve platelet count and function, nor tests of coagulation. Fibrinogen concentrations were lower in the PRP group on the operative day (P < 0.05), suggesting increased fibrinogen consumption; and more patients in the PRP group had low haptoglobin levels during CPB (8/19 vs 0/20 patients, P < 0.005), which indicated greater haemolysis in this group. We conclude that acute preoperative plateletpheresis offers no advantage in haemostasis during elective primary myocardial revascularization surgery.
authors.affiliation: Department of Anaesthesia, Singapore General Hospital.
authors.forename: S K
authors.initials: SK
authors.lastname: Boey
authors.forename: B C
authors.initials: BC
authors.lastname: Ong
authors.forename: S S
authors.initials: SS
authors.lastname: Dhara
mesh_terms: D000768:Anesthesia, General; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D017707:Erythrocyte Transfusion; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D010976:Platelet Count; D010983:Plateletpheresis / Q000379:methods; D011300:Preoperative Care; D011446:Prospective Studies; D012501:Saphenous Vein / Q000637:transplantation
chemical_list: D006242:Haptoglobins; D005340:Fibrinogen