DNA profiles of chimeric twins, TS and MR using the single-locus-probe technique.
A pair of blood-group-chimeric twins, TS and MR and their family have been investigated with the single-locus-probe DNA technique for restriction fragment length polymorphism in five variable-numbers-of-tandem-repeat systems. An admixture of DNA from the other twin could be demonstrated in both twins, leading to a possible false-genotype determination in at least one system. Chimerism is a potential pitfall in DNA investigations with single-locus probes in forensic genetics.
Hansen
H E
HE
Institute of Forensic Genetics, University of Copenhagen, Denmark.
Søndervang
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D015139:Blotting, Southern; D002678:Chimera / Q000235:genetics*; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D008297:Male; D015336:Molecular Probe Techniques; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics*
D015342:DNA Probes; D004247:DNA