title: A pulsatile cardiopulmonary bypass system that prevents negative pressure at the membrane oxygenator.
abstract: Negative pressure is a problem in pulsatile cardiopulmonary bypass (CPB). To avoid this, the authors designed a pulsatile CPB system containing a Sarns centrifugal pump (CP) and a Univox membrane oxygenator, in which the inertial flow is not obstructed by the CP. In both an in vitro study and a clinical study, negative pressure was not observed in the arterial line of the CPB circuit when this system was used. When a roller pump (RP) was used, however, instead of a CP, negative pressure did occur. In a clinical study using this system, mean pulse pressure was 36 mmHg and hemolysis, expressed as the rate of rise in plasma free hemoglobin from 10 to 70 min of CPB, was 26.2 mg/dl/hr, which did not exceed that seen with a pulsatile CPB using an RP instead of a CP. The hemolysis seen in the study caused no clinical problems. Thus, pulsatile CPB using a CP and Univox membrane oxygenator should be considered for clinical use to prevent the occurrence of negative pressure.
authors.affiliation: First Department of Surgery, Kagawa Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Komoda
authors.forename: H
authors.initials: H
authors.lastname: Maeta
authors.forename: S
authors.initials: S
authors.lastname: Imawaki
authors.forename: Y
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: I
authors.initials: I
authors.lastname: Arioka
authors.forename: S
authors.initials: S
authors.lastname: Fukunaga
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Nasu
mesh_terms: D002315:Cardiopulmonary Bypass; D006801:Humans; D010107:Oxygenators, Membrane; D010976:Platelet Count; D011312:Pressure