[Cell morphology and surface markers in three patients with granular lymphocyte proliferative disorders of the T-cell type].
We studied the relationship between cell morphology and surface markers in three patients with granular lymphocyte proliferative disorders. In the two patients with CD3+ CD4-CD8+ cells, there were no atypical cells, and the granules were uniformly fine: In the third patient, who had CD3+ CD4+ CD8- cells, atypical nuclei and the irregular granules in in size were observed. The granules were stained with beta-glucuronidase showing localized coarse features and made clumps, in the staining pattern characteristic of granular lymphocytes. The patient with CD4- CD8+ cells showed cytotoxic T cell phenotype, and the other DN cells type (usually associated with a CD3+ CD4- CD8- phenotype). We obtained conflicting data about OK-NK and Leu 11 antibodies, which recognized CD16 antigen.
Mishima
M
M
Kagoshima City Medical Association Clinical Examination Center.
Harada
K
K
Kozono
T
T
Maruyama
I
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000032:analysis*; D005260:Female; D006098:Granulocytes / Q000276:immunology / Q000648:ultrastructure*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000097:blood* / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface