Peripheral blood hairy cell leukemia cells express only low affinity IL-2 receptors.
Purified leukemia cells from three patients with hairy cell leukemia were studied for IL-2 receptor status. All samples expressed the p55IL-2 receptor subunit. However, none demonstrated sensitivity to the IL-2-diphtheria toxin conjugate, DAB486IL-2, which shows selective cytotoxicity for high affinity IL-2 receptor-bearing cells. In the one case studied with 125I-IL-2 binding, only low affinity IL-2 receptors were noted. These data suggest that hairy cell leukemia cells express only low affinity IL-2 receptors and are insensitive to DAB486IL-2.
Bulger
K
K
Section of Medical Oncology, Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118.
Murphy
J
J
Janckila
A
A
Nichols
J
J
McCaffrey
R
R
D004167:Diphtheria Toxin / Q000494:pharmacology; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D011993:Recombinant Fusion Proteins; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
C054780:DAB(486)-interleukin 2; D004167:Diphtheria Toxin; D000922:Immunotoxins; D007376:Interleukin-2; D010446:Peptide Fragments; D015375:Receptors, Interleukin-2; D011993:Recombinant Fusion Proteins