title: Expression of class I homeobox genes in fetal and adult murine skin.
abstract: We examined the expression patterns of several class I homeobox genes in mouse fetal and adult skin. All the genes of the Hox-B locus, except Hoxb-1, are expressed in skin from murine fetuses of 17 and 18 d gestation, at which time the epidermis is undergoing stratification and differentiation. The amount of individual Hox gene message varies considerably, but expression of all genes is detectable by RNase protection except Hoxb-1, which could not be detected even by the reverse transcription-polymerase chain reaction (RT-PCR) assay. Homeobox gene expression in skin is not confined to the Hox-B locus; the paralogous genes Hoxa-4, -b-4, -c-4, and -d-4 are all expressed. The amount of Hoxb-4, -b-2, and -c-4 message in skin is relatively constant from the earliest gestational day examined (day 16) through birth at day 19. Expression of several homeobox genes is also seen in adult skin.
authors.affiliation: San Francisco VA Medical Center, CA 94121.
authors.forename: K
authors.initials: K
authors.lastname: Detmer
authors.forename: H J
authors.initials: HJ
authors.lastname: Lawrence
authors.forename: C
authors.initials: C
authors.lastname: Largman
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001483:Base Sequence; D002874:Chromosome Mapping; D005314:Embryonic and Fetal Development; D005333:Fetus / Q000502:physiology*; D015870:Gene Expression; D005801:Genes, Homeobox; D051379:Mice / Q000196:embryology / Q000235:genetics*; D008815:Mice, Inbred Strains; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012867:Skin / Q000196:embryology; D012879:Skin Physiological Phenomena
chemical_list: D015335:Molecular Probes