title: 6-Hydroxy dopamine does not affect lens-induced refractive errors but suppresses deprivation myopia.
abstract: Degradation of the retinal image by translucent occluders during postnatal development induces axial myopia in chickens, tree shrews and monkeys. Local visual deprivation produces myopia even in local regions of the eye and neither accommodation nor intact connection between the eye and the brain are necessary. Therefore, it is an important question whether a similar local-retinal pathway translating visual information into growth or stretch signals to the underlying sclera is acting to emmetropize the growing eye. It is not known until now whether occluder deprivation triggers similar eye growth (or scleral stretch) mechanisms that are also responsible for visual guidance of normal refractive development. We here report that, in chickens, 6-hydroxy dopamine suppresses deprivation-induced myopia but has no effect on the magnitude of changes in axial eye elongation that are induced by spectacle lenses. The result suggests that, in chickens with normal accommodation, two pharmacologically different feedback loops may be responsible for deprivation myopia and lens-induced refractive errors.
authors.affiliation: Department of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, Tübingen, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Schaeffel
authors.forename: G
authors.initials: G
authors.lastname: Hagel
authors.forename: M
authors.initials: M
authors.lastname: Bartmann
authors.forename: K
authors.initials: K
authors.lastname: Kohler
authors.forename: E
authors.initials: E
authors.lastname: Zrenner
mesh_terms: D000818:Animals; D001699:Biometry; D002645:Chickens; D005123:Eye / Q000473:pathology; D007909:Lenses; D009216:Myopia / Q000517:prevention & control*; D016627:Oxidopamine / Q000627:therapeutic use*; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000209:etiology; D012683:Sensory Deprivation / Q000502:physiology*
chemical_list: D016627:Oxidopamine