[Effect of alpha-tocopherol on the development of diabetic angiopathy, platelet aggregation and status of the prostacyclin-thromboxane system in rats with streptozotocin diabetes].
Under study were effects of intravenous infusions of a new emulsion, alpha-tocopherol, on the development of diabetic microangiopathy, platelet alpha-tocopherol level, ADP-induced platelet aggregation level, exogenic (from 14C-arachidonic acid) thromboxane (TxA2) biosynthesis in suspension of washed platelets and of prostacyclin (PgI2) one in isolated aortic rings of rats with streptozotocin-induced diabetes. Six-week injections of alpha-tocopherol in a dose 100 mg/100 g b. w. with 48 h intervals immediately after development of streptozotocin-induced diabetes prevented the development of diabetic angiopathy but did not normalize platelet functional activity and PgI2/TxA2 balance in vessels and platelets. Similar injections of alpha-tocopherol in the presence of developed angiopathy resulted in its regressive development and normalization of the before-said prostanoid balance and platelet characteristics.
Zadkova
G F
GF
Avakian
T Iu
TIu
Markov
Kh M
KhM
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D004655:Emulsions; D011464:Epoprostenol / Q000096:biosynthesis*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013928:Thromboxane A2 / Q000096:biosynthesis*; D014810:Vitamin E / Q000627:therapeutic use*
D004655:Emulsions; D014810:Vitamin E; D013928:Thromboxane A2; D011464:Epoprostenol
Vliianie alpha-tokoferola na razvitie diabeticheskoĭ angiopatii, agregatsiiu trombotsitov i sostoianie sistemy prostatsiklin-tromboksan u krys so streptozototsinovym diabetom.