P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme.
Dolle
R E
RE
Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
Hoyer
D
D
Prasad
C V
CV
Schmidt
S J
SJ
Helaszek
C T
CT
Miller
R E
RE
Ator
M A
MA
D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D020170:Caspase 1; D002401:Cathepsin B / Q000037:antagonists & inhibitors; D002460:Cell Line; D002723:Chlorobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data
D002723:Chlorobenzoates; C086205:N-benzyloxycarbonyl-3-amino-5-carboxy-2-oxopent-1-yl 2,6-dichlorobenzoate; D001224:Aspartic Acid; D002401:Cathepsin B; D020170:Caspase 1; D008666:Metalloendopeptidases