Expression of intercellular adhesion molecule-1 in hepatocellular carcinoma.
The expression of intercellular adhesion molecule-1 (ICAM-1) was investigated in frozen sections obtained from 40 resected liver specimens of patients with hepatocellular carcinoma using immunoperoxidase techniques and immunoelectron microscopy. ICAM-1 was expressed in 80% of the HCC specimens on the membrane of cancer cells. In noncancerous regions characterized by cirrhosis in 28 cases and chronic hepatitis in 12 cases, ICAM-1 was rarely expressed on hepatocytes but was expressed mainly on the endothelium of portal vessels and sinusoidal lining cells. These results suggest that expression of ICAM-1 in hepatocellular carcinoma may be induced by malignant transformation of hepatocytes.
Torii
A
A
Department of Surgery II, Nagoya University School of Medicine, Japan.
Harada
A
A
Nakao
A
A
Nonami
T
T
Ito
M
M
Takagi
H
H
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000737:chemistry*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D016009:Chi-Square Distribution; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1; D008113:Liver Neoplasms / Q000737:chemistry*; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1