title: [Effect of azathioprine on immunologic parameters in patients with newly diagnosed insulin-dependent diabetes mellitus].
abstract: Azathioprine immunosuppressive therapy prolongs remissions and stimulates residual beta-cell function, suppresses insulin antibody production, reduces the activity of the complement and CH50 components, reduces initially increased cellular immunity parameters (total T and B cell counts, T helper to T inductor ratio, and the count of DR carrier cells) in patients with newly detected insulin-dependent diabetes mellitus; this makes this drug effective at the first stages of the disease. When selecting patients for immunosuppressive therapy the following immunity parameters should be examined: complement status, total counts of T and B lymphocytes, T-helper-inductor/T-suppressor-cytotoxic immunoregulation index, DR carrier cell counts. Reduced levels thereof are a contraindication against immunosuppressant therapy. Male patients with insulin-dependent diabetes mellitus debut at the age of over 25 are particularly susceptible to immunosuppressive therapy with azathioprine.
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Shamkhalova
authors.forename: I A
authors.initials: IA
authors.lastname: Abugova
authors.forename: P I
authors.initials: PI
authors.lastname: Shishko
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
authors.forename: L V
authors.initials: LV
authors.lastname: Kozlov
authors.forename: V A
authors.initials: VA
authors.lastname: Aleshkin
authors.forename: M N
authors.initials: MN
authors.lastname: Rozina
mesh_terms: D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D001379:Azathioprine / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects; D002096:C-Peptide / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003165:Complement System Proteins / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D012074:Remission Induction / Q000379:methods; D012727:Sex Characteristics; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
chemical_list: D002096:C-Peptide; D003165:Complement System Proteins; D001379:Azathioprine
vernacular_title: Vliianie azatioprina na immunologicheskie pokazateli u bol'nykh s vpervye vyiavlennym insulinzavisimym sakharnym diabetom.