Genetic relationships between foot-and-mouth disease type Asia 1 viruses.
The sequence of 165 nucleotides at the 3' end of the 1D (VP1) gene of foot-and-mouth disease (FMD) virus was determined for 44 type Asia 1 strains isolated from throughout Asia between 1954-92. Analysis of the relationships between the virus genomes showed epidemiological links not previously evident. The possible origin of the only outbreak of FMD Asia 1 to have occurred in Europe, in Greece in 1984, was identified because the nucleotide sequence of this virus was closely-related to the sequences of those present in the Middle East between 1983-5. Variation in the region sequenced was not as great as that seen in the other FMDV serotypes and all viruses shared greater than 85% nucleotide identity. Thus all the virus isolates examined were considered to belong to a single genotype. A database of Asia 1 virus sequences has been established which will facilitate the rapid analysis of new outbreaks strains.
Ansell
D M
DM
AFRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.
Samuel
A R
AR
Carpenter
W C
WC
Knowles
N J
NJ
D000595:Amino Acid Sequence; D000818:Animals; D005537:Aphthovirus / Q000145:classification / Q000235:genetics*; D001208:Asia; D001483:Base Sequence; D002417:Cattle; D016000:Cluster Analysis; D017931:DNA Primers / Q000737:chemistry; D005536:Foot-and-Mouth Disease / Q000382:microbiology*; D005814:Genes, Viral; D005838:Genotype; D008838:Microcomputers; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000737:chemistry
D017931:DNA Primers; D012367:RNA, Viral