The influence of ethanol on pentetrazol-induced seizures and anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice.
The effect of acute (1, 2, and 3 g/kg) and chronic (2 g/kg) ethanol administration and ethanol withdrawal on pentetrazol-induced seizures and influence of ethanol in a dose of 2 g/kg upon the protective efficacy of valproate and phenobarbital against maximal electroshock-induced seizures was investigated. In the acute study ethanol increased, in the chronic study ethanol had no effect on ED50 values for pentetrazol. During withdrawal the ED50 was reduced. In the acute study ethanol reduced ED50 values for valproate and phenobarbital, in the chronic study had no effect. During withdrawal ED50 values for phenobarbital were elevated.
Kleinrok
Z
Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Dziki
M
M
Janczarek
T
T
D000818:Animals; D004347:Drug Interactions; D004597:Electroshock; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006614:Hindlimb; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use*; D012044:Regression Analysis; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000494:pharmacology / Q000627:therapeutic use*
D000431:Ethanol; D014635:Valproic Acid; D010433:Pentylenetetrazole; D010634:Phenobarbital