Asthma, inflammation, and airway hyperresponsiveness in children.
Consensus recommendations for the management of childhood asthma have focused on the inflammatory nature of the disease as the principal problem. Recent publications on both the pathogenesis and the treatment of childhood asthma confirmed this approach. Bronchoalveolar lavage studies showed elevated numbers of inflammatory cells in the airways of children with asthma. Long-term studies showed that anti-inflammatory therapy is superior to bronchodilators for improving pulmonary function and decreasing bronchial hyperreactivity. Previous suggestions that bronchodilator therapy may increase bronchial hyperreactivity have not been supported.
Murphy
S
S
University of New Mexico School of Medicine, Albuquerque.
Kelly
H W
HW
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000485:Allergens; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D017835:Nedocromil; D015363:Quinolones / Q000627:therapeutic use; D013806:Theophylline / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D000485:Allergens; D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D015363:Quinolones; D017835:Nedocromil; D013806:Theophylline