title: [Peripheral benzodiazepine receptors and their possible biological role].
abstract: While specific BZD receptors in the central nervous system were identified using [3H]diazepam as radioligand, additional binding sites have been found also in peripheral tissues. These so-called "peripheral-type benzodiazepine receptors" occur ubiquitous in various tissues. Different actions on biological processes have been described to be connected with peripheral-type benzodiazepine receptors, but their definite physiological role has not yet been clarified. this review covers basic findings of this second binding site for benzodiazepines, trying to present a survey about those binding sites and their putative biological role.
authors.affiliation: Dr. Margarete-Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart.
authors.forename: B E
authors.initials: BE
authors.lastname: Alexander
authors.forename: U
authors.initials: U
authors.lastname: Klotz
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism; D001569:Benzodiazepines; D006801:Humans; D011963:Receptors, GABA-A / Q000502:physiology*
chemical_list: D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D001569:Benzodiazepines
vernacular_title: Periphere Benzodiazepinrezeptoren und deren mögliche biologische Bedeutung.