Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26.
A genetic map of highly polymorphic microsatellite markers spanning the von Hippel-Lindau region (VHL) of 3p25 was constructed using the CEPH reference pedigrees. A greater than 1000:1 odds map of pter-D3S1038-RAF1-D3S651-D3S656-D3S110- D3S1255-cen was found. Genotyping of six multigenerational VHL families showed the region surrounding the D3S1038 marker to be the most likely location for the VHL gene with a peak location score of 10.04 with VHL completely linked to D3S1038. These data provide an initial high resolution genetic map of this region; D3S1038 appears to be a highly polymorphic marker that should prove useful in the future for presymptomatic diagnosis.
Pericak-Vance
M A
MA
Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710.
Nunes
K J
KJ
Whisenant
E
E
Loeb
D B
DB
Small
K W
KW
Stajich
J M
JM
Rimmler
J B
JB
Yamaoka
L H
LH
Smith
D I
DI
Drabkin
H A
HA
D000328:Adult; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D016384:Consensus Sequence; D004276:DNA, Satellite / Q000032:analysis; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid; D006623:von Hippel-Lindau Disease / Q000235:genetics*
D004276:DNA, Satellite; D005819:Genetic Markers