Chronological loss of bone zinc during dietary zinc deprivation in neonatal pigs.
This research was conducted to measure the chronological changes in zinc concentrations of biopsied bone, hair, and plasma samples collected weekly during dietary zinc deprivation. Pigs 1-2 wk of age were fed a basal diet (< 1 microgram Zn/g) during a 1-wk depletion period and then assigned to one of three dietary regimens for 4 wk: a low-zinc diet (4 micrograms Zn/g) fed ad libitum, an adequate-zinc diet (100 micrograms/g) fed ad libitum, and an adequate-zinc diet restricted in intake to allow eight gain comparable with that of the low-zinc group. Bone zinc remained at approximately 120 micrograms/g dry wt for the control groups fed adequate zinc but steadily declined in pigs fed the low-zinc diet, leveling off at approximately 25% of the control values. Plasma and hair zinc concentrations also decreased but at a more rapid rate. Bone zinc is mobilizable in neonatal pigs, and biopsied bone zinc concentration is a reliable index of zinc status.
Bobilya
D J
DJ
Department of Animal Sciences, University of Missouri, Columbia 65211.
Johanning
G L
GL
Veum
T L
TL
O'Dell
B L
BL
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D001846:Bone Development / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D006197:Hair / Q000737:chemistry; D008297:Male; D013552:Swine; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism*
D015032:Zinc