Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation.
The pathophysiological mechanisms involved in the development of a spontaneous systemic capillary leak syndrome (CLS) are unknown. In contrast, CLS is a well-known side effect of high-dose interleukin-2 (IL-2) therapy in solid tumors. We report on a patient who developed CLS with high serum levels of endogenous IL-2 under immunosuppressive therapy for chronic graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT). Generalized edema persisted for 10 weeks. The condition resolved after antibiotic therapy of a septic shock with beta hemolyzing streptococci group A. Thus, a latent infection may alter cytokine homeostasis and may cause CLS in BMT patients.
Funke
I
I
Department of Internal Medicine III, University of Ulm, Germany.
Prümmer
O
O
Schrezenmeier
H
H
Hardt
D
D
Weiss
M
M
Porzsolt
F
F
Arnold
R
R
Heimpel
H
H
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002199:Capillary Permeability; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood; D006086:Graft vs Host Disease / Q000628:therapy; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes; D013577:Syndrome; D014184:Transplantation, Homologous
D000900:Anti-Bacterial Agents; D016207:Cytokines; D007376:Interleukin-2