title: The effect of infection and lag screw fixation on the union of membranous bone grafts in a rabbit model.
abstract: Infection complicating craniofacial procedures contributes significantly to patient morbidity and health care costs. The role of fixation materials in this setting remains unclear. As foreign material, does fixation hardware increase patients' susceptibility to developing postoperative infection? Furthermore, once infection is established, should fixation hardware be removed? To answer these questions, we performed an onlay membranous bone grafting procedure to the mandible in 94 New Zealand White rabbits, applied lag-screw fixation in half the animals, and inoculated the wounds with different bacterial doses. We quantified the differential rates of infection and rates of graft union in the presence of infection. The infection rates for the rigidly fixated group were not significantly different from the rates for the nonfixated group for a range of bacterial inoculum doses. There was no significant difference in the rates of resolution of infection and sepsis between the two groups. Gross and histologic assessments revealed a significantly lower union rate for infected grafts when compared with uninfected grafts. Furthermore, grafts rigidly fixated with a lag screw showed a higher rate of union when compared with nonfixated grafts in the presence of infection. In the absence of infection, the union rates for fixated and nonfixated groups did not differ significantly. While fixation hardware has been cited as a risk factor for postoperative infection, we were unable to show that lag-screw fixation contributes to this risk. Although infection impaired the union of membranous bone grafts to the recipient mandible, fixation of the grafts with a lag screw significantly decreased this deleterious effect of infection.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Plastic Surgery, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Fialkov
authors.forename: J H
authors.initials: JH
authors.lastname: Phillips
authors.forename: S L
authors.initials: SL
authors.lastname: Walmsley
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D001863:Bone Screws / Q000009:adverse effects; D016025:Bone Transplantation / Q000473:pathology / Q000502:physiology*; D015169:Colony Count, Microbial; D005260:Female; D008334:Mandible / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010326:Pasteurella Infections / Q000503:physiopathology; D016979:Pasteurella multocida; D011817:Rabbits; D012307:Risk Factors; D018805:Sepsis / Q000382:microbiology / Q000503:physiopathology; D013203:Staphylococcal Infections / Q000503:physiopathology; D013530:Surgical Wound Infection / Q000503:physiopathology*; D014945:Wound Healing; D015050:Zygoma / Q000601:surgery