[A stereological analysis of the myocardium in rats adapting to the conditions at high latitudes].
Qualitative and quantitative morphologic analysis of myocardium of Wistar rats were carried out when they have been transferred to high latitudes (being in latitude 69 degrees north during 37 days). It was shown, that already in a day after transferring to high latitudes pronounced disorders of lymph and blood circulations developed and heterogeneity of cardiomyocyte lesions was noted. By the end of the experiment atrophic and necrobiotic cardiomyocytes resorbed by macrophages were registered. In the group of animals, whose were transported in middle latitudes morphologic changes in myocardium gradually increased by the end of the experiment. Stereologic analysis revealed stereotype dynamics of tissue reorganization of myocardium in both animal groups. A key event in tissue reorganization of myocardium was the significant decrease of volume and surface densities of capillaries at 12th day of experiment and as consequence of these changes the volume and surface-to-volume ratios of capillaries to cardiomyocytes were decreased. The decrease of these parameters was more pronounced in animals whose were transported to high latitudes.
Nepomniashchikh
L M
LM
Lushnikova
E L
EL
Nepomniashchikh
G I
GI
D000222:Adaptation, Physiological; D000818:Animals; D003081:Cold Climate; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D012800:Siberia; D013997:Time Factors
Stereologicheskiĭ analiz miokarda krys pri adaptatsii k usloviiam vysokikh shirot.