title: A double-blind placebo controlled study of a 5% lidocaine/prilocaine cream (EMLA) for topical anesthesia during thermolysis.
abstract: BACKGROUND
  Electrolysis and thermolysis are commonly used electrosurgical methods for the permanent destruction of unwanted hair. However, patient fear of pain during treatment may interfere with or even prevent desired treatment of hirsutism on sensitive areas such as the upper lip.
  
  
  OBJECTIVE
  This study was conducted to assess the efficacy of EMLA (Eutetic Mixture of Local Anesthetics), a 5% lidocaine/prilocaine cream, as a topically applied local anesthetic during thermolysis on the upper lip.
  
  
  METHODS
  A double-blind placebo control study was conducted by the University of Texas Medical Branch thermolysis clinic. Thirty women with idiopathic hirsutism of the upper lip were studied. Pain was measured with a 100 mm visual analog scale (VAS).
  
  
  RESULTS
  Total paired VAS score differences comparing the placebo VAS scores to the EMLA VAS scores were significant by paired t-test (P = .0001). Adverse reactions were mild and transient.
  
  
  CONCLUSIONS
  EMLA cream may have multiple applications to the practice of dermatologic surgery, including topically achieved local anesthesia during thermolysis and electrolysis.
authors.affiliation: University of Texas Medical Branch Thermolysis Clinic, Department of Dermatology, Galveston 77555-0783.
authors.forename: R F
authors.initials: RF
authors.lastname: Wagner
authors.forename: C A
authors.initials: CA
authors.lastname: Flores
authors.forename: L F
authors.initials: LF
authors.lastname: Argo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006204:Hair Removal / Q000295:instrumentation / Q000379:methods*; D006628:Hirsutism / Q000628:therapy*; D006358:Hot Temperature; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects; D000077442:Lidocaine, Prilocaine Drug Combination; D008047:Lip Diseases / Q000628:therapy*; D008875:Middle Aged; D009824:Ointments; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D010919:Placebos; D011318:Prilocaine / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D010919:Placebos; D011318:Prilocaine; D008012:Lidocaine