Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family.
The interleukin-1 receptor in mammals and the product of the Toll gene in Drosophila are related transmembrane receptors, involved in the activation of transcription factors of the rel family. Whereas the interleukin-1 receptor mediates the effects of interleukin-1 in the immune system, Toll is part of the system that determines dorsoventral polarity in the Drosophila embryo, although Toll may also have a function in the immune response in the fly. Here, I demonstrate that the open reading frame of MyD88, a gene induced in myeloid differentiation, is related to the cytoplasmic domains of the interleukin-1 receptor and the Toll gene product. The three related proteins define a family of signal transmitters, the original function of which may be to mediate responses in the immune system.
Hultmark
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Department of Molecular Biology, Stockholm University, Sweden.
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation; D002454:Cell Differentiation; D002645:Chickens; D029721:Drosophila Proteins; D004331:Drosophila melanogaster; D006801:Humans; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D008969:Molecular Sequence Data; D053594:Myeloid Differentiation Factor 88; D011506:Proteins / Q000235:genetics*; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1 / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; D029721:Drosophila Proteins; C507779:MYD88 protein, human; C499312:Myd88 protein, Drosophila; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D011506:Proteins; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1