title: Mid-latency auditory evoked potentials and circulatory response to loud sounds.
abstract: We investigated in 60 patients scheduled for elective aorto-coronary bypass grafting if loud sounds by themselves can induce cardiovascular responses and if these could be related to mid-latency auditory evoked potentials (MLAEP). Anaesthesia was induced in group I (n = 20) with flunitrazepam-fentanyl 0.01 mg kg-1 and maintained with flunitrazepam-fentanyl 1.2 mg h-1. Patients in groups II (n = 20) and III (n = 20) received etomidate 0.25 mg kg-1 and fentanyl 0.005 mg kg-1 for induction and 0.6-1.2 vol% isoflurane and fentanyl 1.2 mg h-1, or propofol 4-8 mg kg-1 h-1 and fentanyl 1.2 mg h-1 for maintenance of general anaesthesia. After preparation of the sternum the operation was stopped for several minutes. Then, as a loud auditory stimulus, the sound of the running sternotomy saw was presented to the patients by putting the saw inverted on the sternum for several seconds. Heart rate (HR), arterial pressure (SAP), pulmonary capillary wedge pressure (PCWP), cardiac index, systemic vascular resistance and MLAEP were measured in the awake state, before and after presentation of the sound. Latencies of the peak V, Na, Pa, Nb and P1 were measured. In group I there were statistically significant increases in HR (63.5-70.2 beat min-1), SAP (123.9-146-5 mm Hg) and PCWP (9.2-11.7 mm Hg) after presentation of the sound. These haemodynamic changes were not observed in patients in groups II and III. In the awake state, AEP had high peak -to-peak amplitudes and a periodic waveform.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Institute for Anaesthesiology, Ludwig-Maximilians-University, München, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Schwender
authors.forename: R
authors.initials: R
authors.lastname: Haessler
authors.forename: S
authors.initials: S
authors.lastname: Klasing
authors.forename: C
authors.initials: C
authors.lastname: Madler
authors.forename: E
authors.initials: E
authors.lastname: Pöppel
authors.forename: K
authors.initials: K
authors.lastname: Peter
mesh_terms: D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D005045:Etomidate; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005283:Fentanyl; D005445:Flunitrazepam; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007530:Isoflurane; D011897:Random Allocation; D013016:Sound; D013997:Time Factors
chemical_list: D005445:Flunitrazepam; D007530:Isoflurane; D005283:Fentanyl; D005045:Etomidate