Non-cytolytic control of HIV replication by CD8+ T cells.
Replication of the human immunodeficiency virus (HIV) in CD4+ cells is suppressed in the presence of CD8+ cells from asymptomatic HIV-infected individuals. Although these CD8+ cells mediate HIV-specific, class I MHC restricted CTL activity, the predominant mechanism for inhibiting virus replication requires neither contact nor MHC matching between the CD8+ effector cells and CD4+ targets. Based on these data, a model involving two tiers of control on HIV replication by CD8+ cells is proposed. The first level would be mediated by a diffusible CD8+ cell-derived factor that prevents expression of the retroviral genome in a non-MHC restricted fashion. When this transcriptional control is lost, production of HIV proteins would sensitize the cell for lysis by class I MHC restricted, virus-specific CTL.
Walker
C M
CM
Chiron Corporation, Emeryville, CA 94608.
D000818:Animals; D000998:Antiviral Agents / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000382:microbiology; D002450:Cell Communication; D016207:Cytokines / Q000502:physiology*; D003602:Cytotoxicity, Immunologic; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology / Q000382:microbiology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D008253:Macaca mulatta / Q000276:immunology / Q000382:microbiology; D008954:Models, Biological; D002679:Pan troglodytes / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D016207:Cytokines; D015395:Histocompatibility Antigens Class I