title: [The antimutagenic effect of adaptation to stress].
abstract: C57BL mice were adapted to moderate periodic hypoxia and repeated electric pain stresses of limited intensity. These animals adapted to each of the factors and control animals were given the potent mutagen, free radical oxidation activator dioxidine in a single dose of 300 mg/kg. Dioxidine administered to unadapted animals resulted in chromosomal aberrations in 11% of stem bone marrow cells mainly due to the appearance of single and multiple chromosomes. Preadaptation to stress decreased the number of these dioxidine-induced chromosomal aberrations nearly twice. Adaptation to periodic hypoxia had no defensive action. As previously shown, adaptation to repeated stresses leads to the accumulation of heat-shock proteins (HSP) in the cellular nuclei of animals and prevents the degradation of isolated nuclei when single-chain DNA is added. Adaptation to hypoxia does not cause nuclear accumulation of HSP or prevents their degradation when unicellular DNA is supplemented. This suggests that the antimutagenic effect of stress adaptation is likely to be accounted for by the stabilizing action of HSP.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Meerson
authors.forename: A V
authors.initials: AV
authors.lastname: Kulakova
authors.forename: V A
authors.initials: VA
authors.lastname: Saltykova
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000235:genetics*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations / Q000235:genetics / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D000860:Hypoxia / Q000235:genetics / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016296:Mutagenesis / Q000187:drug effects / Q000502:physiology*; D009153:Mutagens / Q000494:pharmacology; D010146:Pain / Q000235:genetics / Q000503:physiopathology; D010507:Periodicity; D011810:Quinoxalines / Q000494:pharmacology; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology*
chemical_list: D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine
vernacular_title: Antimutagennyĭ éffekt adaptatsii k stressu.