Influence of time until emesis on the efficacy of decontamination using acetaminophen as a marker in a pediatric population.
OBJECTIVE
To determine the extent of drug removal by emesis at different times after the ingestion of a toxic substance.


METHODS
Multicenter retrospective chart review.


METHODS
Using the American Association of Poison Control Centers' aggregate data base, children who had ingested acetaminophen and who were referred to a health care facility by one of 11 poison centers during a two-year period were identified. Charts of these patients were reviewed to determine the quantity ingested per kilogram of body weight, method of decontamination used, the timing of decontamination, and the serum acetaminophen concentration obtained four hours after ingestion.


RESULTS
Charts of 455 patients met all requirements for inclusion. When emesis occurred within one-half hour after ingestion, mean serum acetaminophen concentration drawn four hours after ingestion was approximately half that in a control group that received no decontamination. Emesis had less impact when it was delayed further and had no demonstrable impact when it occurred more than 90 minutes after ingestion.


CONCLUSIONS
Many factors must be considered when deciding if and by what method a given patient should receive decontamination. When delayed gastric emptying is not expected, emesis can at best decrease a toxic burden by half if it occurs early. Medical care givers must continue to scrutinize management practice to ensure that syrup of ipecac is given only in situations in which it is likely to make a difference in outcome and in which it is the most effective agent to achieve this goal.
Bond
G R
GR
Samaritan Regional Poison Center, Phoenix, Arizona.
Requa
R K
RK
Krenzelok
E P
EP
Normann
S A
SA
Tendler
J D
JD
Morris
C L
CL
McCoy
D J
DJ
Thompson
M W
MW
McCarthy
T
T
Roblez
J
J
D000082:Acetaminophen / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D015415:Biomarkers; D001822:Body Burden; D002606:Charcoal / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D003666:Decontamination / Q000379:methods*; D004363:Drug Utilization; D005751:Gastric Lavage / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007486:Ipecac / Q000494:pharmacology* / Q000627:therapeutic use*; D011039:Poison Control Centers; D011041:Poisoning / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology; D012017:Referral and Consultation; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D014839:Vomiting / Q000139:chemically induced*
D015415:Biomarkers; D002606:Charcoal; D000082:Acetaminophen; D007486:Ipecac