Short-term changes in lipid and protein metabolism in liver transplants from living-related donors.
The effects of liver transplantation involving living-related donors were investigated in 20 pediatric cases in terms of protein and lipid metabolism using the extent of cholesterol esterification and the levels of total cholesterol, lecithine-cholesterol acyltransferase, apolipoprotein A-I, cholinesterase, and rapid turnover proteins as parameters. Cholesterol esterification increased from preoperative values of 39% +/- 4% to 67% +/- 1% (mean +/- SEM, n = 17) at 3 weeks after liver transplantation in successful cases but decreased from the preoperative value of 45% +/- 10% to 26% +/- 6% (n = 3) at 3 weeks in unsuccessful cases. Cholinesterase, transferrin, and prealbumin levels remained low after 3 weeks even in successful cases. Patients who had partial liver transplantations from living-related donors showed rapid recovery of cholesterol esterification. However, patients with graft livers required an extensive period before normalization of protein metabolism occurred, indicating the necessity for long-term follow-up of recipient development.
Tanaka
A
A
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Sano
K
K
Tanaka
K
K
Honda
K
K
Uemoto
S
S
Takada
Y
Y
Yamaoka
Y
Y
Inamoto
T
T
Shimahara
Y
Y
Mori
K
K
D000293:Adolescent; D016632:Apolipoprotein A-I / Q000032:analysis / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000032:analysis / Q000378:metabolism; D001663:Bilirubin / Q000032:analysis / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D002788:Cholesterol Esters / Q000032:analysis / Q000378:metabolism; D002802:Cholinesterases / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D050356:Lipid Metabolism; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000032:analysis / Q000378:metabolism; D011228:Prealbumin / Q000032:analysis / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012177:Retinol-Binding Proteins / Q000032:analysis / Q000378:metabolism; D014019:Tissue Donors; D014168:Transferrin / Q000032:analysis / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000032:analysis / Q000378:metabolism
D016632:Apolipoprotein A-I; D002788:Cholesterol Esters; D011228:Prealbumin; D011506:Proteins; D012177:Retinol-Binding Proteins; D014168:Transferrin; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D002802:Cholinesterases; D001663:Bilirubin