[A new method for quantitative measurement of rCBF using graphic plot analysis: application to 123I-IMP dynamic study].
To estimate regional cerebral blood flow (rCBF) using the dynamic data, a new graphic plot analysis is proposed. By assuming a two-compartment model for the tracer kinetics, we derived the linear relationship as Y(t) = 1/K1 + theta t, where Y(t) is the ratio of time-integrated blood activity to brain tissue activity, t is the scan time, and theta is a proportional constant. A plot of Y(t) against the scan time t yields a straight line and the y-intercept of the line represents the value of inverse rCBF K1. This method was applied to five normal subjects with N-isopropyl-p(123I)iodoamphetamine. The mean value of K1 in the gray matter was 42.1 +/- 6.8 ml/100 g/min. We also produced the rCBF images within a few seconds using the present method. The present graphical method gives a reliable and rapid estimation of rCBF.
Yokoi
T
T
Department of Research for Medical Systems, Shimadzu Corporation, Kyoto, Japan.
Iida
H
H
Itoh
H
H
Kanno
I
I
D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008433:Mathematics; D008955:Models, Cardiovascular; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine