[Role of tumor necrosis factor in immunopathogenesis of pulmonary tuberculosis].
The activity of TNF-alpha in the serum was determined with ELISA basing on 2 monoclonal antibodies varying by epitopic specificity in 25 patients with pulmonary tuberculosis and 4 patients with chronic nonspecific respiratory diseases. TNF-alpha varied with tuberculosis severity and prognostic factors. Its level appeared the highest in fibrocavernous tuberculosis (405.0 +/- 82.9 pg/ml) against 355.0 +/- 32.5 pg/ml in tuberculoma. In the progressive disease TNF-alpha serum level was lower than in stabilization or inactive tuberculosis (334.6 +/- 36.8 pg/ml against 443.7 +/- 32.1). Low TNF-alpha concentrations indicate an adverse run of tuberculosis associated with destruction, intoxication and bacterial discharge.
Surkova
L K
LK
Paniutich
A V
AV
Shpakovskaia
N S
NS
D000328:Adult; D000911:Antibodies, Monoclonal; D002908:Chronic Disease; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012140:Respiratory Tract Diseases / Q000097:blood / Q000276:immunology; D012720:Severity of Illness Index; D014375:Tuberculoma / Q000097:blood / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000276:immunology* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha
Rol faktora nekroza opukholeĭ v immunopatogeneze tuberkulëza lëgkikh.