Internal initiation of translation.
Although the 5' cap-dependent scanning mechanism can account for the translational initiation of most mRNAs in eukaryotic cells, several viral and cellular mRNAs contain nucleotide sequences in their 5' non-coding regions that can mediate binding of ribosomes to the mRNA, regardless of the modification state of the 5' ends. During the past year, some nuclear proteins normally involved in RNA processing have been shown also to facilitate 'internal' ribosome binding. Unexpected dual functions have, therefore, been suggested for these RNA-binding proteins, in both RNA biogenesis in the nucleus and RNA translation in the cytoplasm.
McBratney
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University of Colorado Health Sciences Center, Denver.
Chen
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CY
Sarnow
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D005537:Aphthovirus / Q000235:genetics; D001324:Autoantigens / Q000502:physiology; D001483:Base Sequence; D001692:Biological Transport; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000502:physiology; D006507:Hepatovirus / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism; D010442:Peptide Chain Initiation, Translational; D010849:Picornaviridae / Q000235:genetics; D038941:Polypyrimidine Tract-Binding Protein; D012333:RNA, Messenger / Q000235:genetics; D012343:RNA, Transfer / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D012045:Regulatory Sequences, Nucleic Acid; D012261:Ribonucleoproteins / Q000502:physiology; D000097585:SS-B Antigen
D001324:Autoantigens; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D009687:Nuclear Proteins; D038941:Polypyrimidine Tract-Binding Protein; D012333:RNA, Messenger; D012343:RNA, Transfer; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D000097585:SS-B Antigen