The interaction of mediators with the processes of protein synthesis in neurons of the visual cortex in the goal-directed behavior of cats.
The chemical sensitivity of neurons of the visual area of the cerebral cortex of cats at sequential stages of food-procuring instrumental behavior, formed under the conditions of intraventricular administration of a protein synthesis blocker, cycloheximide, was investigated in the present study. It was demonstrated that in animals with cycloheximide there is a low level of chemical sensitivity of cortical neurons to microiontophoretically applied solutions of acetylcholine and norepinephrine. As compared with intact animals, in the animals with cycloheximide the number of neurons reacting with a change in impulse activity at the stages of instrumental behavior and the number of areactive cells did not depend on the nature of the applied neuromediator.
Andrianov
V V
VV
P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002415:Cats; D003216:Conditioning, Operant / Q000502:physiology; D003513:Cycloheximide / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D007478:Iontophoresis; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D003513:Cycloheximide; D000109:Acetylcholine; D009638:Norepinephrine