Detection of plasma interleukin-8 in atopic dermatitis.
Plasma interleukin-8 (IL-8) concentrations were measured in patients with atopic dermatitis. Plasma IL-8 was not detected in 25 controls (0/25), in allergic rhinitis (0/20), or in bronchial asthma during remission (0/13), while low concentrations of IL-8 were detectable in a few patients with urticaria (1/19), contact dermatitis (4/17), and bronchial asthma at the time of attack (6/16). In contrast, IL-8 was detectable in most cases of atopic dermatitis (41/52). Moreover, IL-8 concentrations were significantly higher in severe than in mild or moderate atopic dermatitis. IL-8 concentrations decreased as atopic dermatitis was improved by treatment, and IgE production in vitro was also decreased while serum IgE concentrations remained unchanged. IL-8 measurement may be a useful tool for the study of the pathogenesis and clinical course of atopic dermatitis.
Kimata
H
H
Department of Paediatrics, Kyoto University Hospital, Japan.
Lindley
I
I
D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000276:immunology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D003877:Dermatitis, Contact / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007223:Infant; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D012220:Rhinitis / Q000097:blood / Q000276:immunology; D014581:Urticaria / Q000097:blood / Q000276:immunology
D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D007073:Immunoglobulin E