Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients.
Levels of CSF fluid interleukin-2, but not interleukin-1 alpha, were found to be higher in 10 neuroleptic-free schizophrenic patients than in 10 healthy subjects matched for sex and age. Because interleukin-2 increases dopaminergic neurotransmission and participates in autoimmunity and cell growth, the authors postulate that elevated levels of central interleukin-2 might contribute to the increased dopaminergic neurotransmission, autoimmune phenomena, and abnormal brain morphology described in some patients with schizophrenia.
Licinio
J
J
Department of Psychiatry, Yale University School of Medicine, West Haven Veterans Affairs Medical Center, CT 06516.
Seibyl
J P
JP
Altemus
M
M
Charney
D S
DS
Krystal
J H
JH
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000494:pharmacology; D015551:Autoimmunity; D004298:Dopamine / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000134:cerebrospinal fluid; D007376:Interleukin-2 / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011954:Receptors, Dopamine / Q000187:drug effects; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000503:physiopathology; D013312:Stress, Physiological / Q000276:immunology; D009435:Synaptic Transmission
D014150:Antipsychotic Agents; D007375:Interleukin-1; D007376:Interleukin-2; D011954:Receptors, Dopamine; D004298:Dopamine