title: Impairment of neuromotor and cognitive development in iodine-deficient schoolchildren with normal physical growth.
abstract: In order to detect somatic and psychomotor disturbances in children and adolescents residing in areas of iodine deficiency, schoolchildren from three areas with different degrees of iodine deficiency were studied. In Randan, the prevalence of severe endemic goiter was accompanied by alteration in thyroid function, increased thyrotropin levels and retardation of both bone and psychomotor age and decreased intellectual quotient. In Tehran, where iodine deficiency is mild, visible goiter was present in 15% of schoolchildren but no alterations in thyroid function, serum thyrotropin, somatic or psychomotor development could be detected. In Zagoon, where the prevalence and severity of goiter was less than Randan but more than Tehran, thyroid function was normal but slightly decreased as compared to Tehran; somatic development was unaltered, but retardation in psychomotor development was evident and the mean intellectual quotient was less than that of Tehranian schoolchildren. These findings indicate the occurrence of physical and psychomotor disturbances in apparently normal schoolchildren from areas of iodine deficiency. Alteration in psychomotor development may occur in children with normal physical growth, due to iodine deficiency.
authors.affiliation: Endocrine Research Centre, Shaheed Bheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
authors.forename: F
authors.initials: F
authors.lastname: Azizi
authors.forename: A
authors.initials: A
authors.lastname: Sarshar
authors.forename: M
authors.initials: M
authors.lastname: Nafarabadi
authors.forename: A
authors.initials: A
authors.lastname: Ghazi
authors.forename: M
authors.initials: M
authors.lastname: Kimiagar
authors.forename: S
authors.initials: S
authors.lastname: Noohi
authors.forename: N
authors.initials: N
authors.lastname: Rahbar
authors.forename: A
authors.initials: A
authors.lastname: Bahrami
authors.forename: S
authors.initials: S
authors.lastname: Kalantari
mesh_terms: D000293:Adolescent; D001846:Bone Development; D002648:Child; D002657:Child Development; D003071:Cognition / Q000502:physiology*; D005260:Female; D006042:Goiter / Q000453:epidemiology; D006801:Humans; D007360:Intelligence; D007455:Iodine / Q000172:deficiency*; D007492:Iran; D008297:Male; D015995:Prevalence; D011594:Psychometrics; D011597:Psychomotor Performance / Q000502:physiology*; D012016:Reference Values; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D007455:Iodine