Species barrier prevents an abnormal isoform of prion protein from accumulating in follicular dendritic cells of mice with Creutzfeldt-Jakob disease.
The accumulation of abnormal prion protein in follicular dendritic cells did not occur in mice inoculated with materials from human Creutzfeldt-Jakob disease, whereas it always occurred in mice inoculated with mouse-adapted agents, suggesting an intense expression of the species barrier in the lymphoreticular system.
Muramoto
T
T
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kitamoto
T
T
Hoque
M Z
MZ
Tateishi
J
J
Goto
I
I
D000368:Aged; D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism*; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D008221:Lymphoid Tissue / Q000378:metabolism; D008297:Male; D051379:Mice; D008875:Middle Aged; D018620:PrPSc Proteins; D011328:Prions / Q000378:metabolism*; D013045:Species Specificity
D018620:PrPSc Proteins; D011328:Prions