Microbiological conversions of solamargine.
A strain of Aspergillus ochraceus, a microorganism classically used for bioconversions of the steroid nucleus, was tested on solasodine glucosides. It induced specific modifications to the oside chain of the solamargine molecule, without modifying the genin nucleus. These modifications depended on the composition of the culture medium and the aeration, and led under certain conditions to a single isomer of the secondary glucoside beta 2-solamargine or Khasianine: o-alpha-L-rhamnopyranosyl-(1-->4 glu)-O-(3)-beta-D-glucopyranosyl solasodine.
Regerat
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F
Laboratoire de Pharmacognosie et de Biotechnologie, Faculté de Pharmacie, Clermont-Ferrand, France.
Texier
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O
Barthomeuf
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C
Fraisse
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D
D001235:Aspergillus ochraceus / Q000378:metabolism*; D005285:Fermentation; D010840:Phytosterols / Q000378:metabolism*; D012991:Solanaceous Alkaloids / Q000378:metabolism*
D010840:Phytosterols; D012991:Solanaceous Alkaloids; C026609:beta-solamarine