Host and environmental effects on plasma apolipoprotein B.
In this study, levels of apo B in an unselected sample of 487 middle-aged Caucasian spouses of patients and spouses of the patients' relatives are described. In males, apo B levels increased with age until the 7th decade, then declined; apo B levels in females, which were lower than in males, increased linearly with age across the entire life-span. Height and weight, smoking, and presence of noninsulin-dependent diabetes mellitus significantly influenced age- and gender-adjusted apo B levels in this sample, whereas use of alcohol, diuretics, beta-blockers, or insulin did not. Age, gender, height, weight, smoking, and noninsulin-dependent diabetes mellitus account for 21% of the total variation in apo B levels in this sample.
Jarvik
G P
GP
Department of Medicine, University of Washington, Seattle 98195.
Wijsman
E
E
Little
R E
RE
Albers
J J
JJ
Motulsky
A G
AG
Brunzell
J D
JD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood; D001055:Apolipoproteins B / Q000378:metabolism*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood*; D004782:Environmental Health; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017678:Sex Distribution
D001055:Apolipoproteins B