title: [Synthesis and analgesic activity of non-aryl analogues of 4-methoxycarbonyl fentanyl].
abstract: In this paper, the synthesis and analgesic activities of some derivatives of 4-methoxycarbonyl fentanyl are reported, in which the 4-N-phenyl group or both the 4-N-phenyl group and the 1-beta-phenyl group were replaced by some nonaromatic groups. In the last case, some compounds showed very strong analgesic activity. For example, the analgesic activities of compounds 4 and 6 were shown to be 695 and 818 times more potent than that of morphine respectively. The structure-analgesic activity relationships were discussed.
authors.affiliation: Nanjing General Hospital of Nanjing Armed Forces.
authors.forename: S T
authors.initials: ST
authors.lastname: Wen
authors.forename: Y L
authors.initials: YL
authors.lastname: Yang
authors.forename: H Z
authors.initials: HZ
authors.lastname: Shao
authors.forename: K G
authors.initials: KG
authors.lastname: Zhang
authors.forename: Y L
authors.initials: YL
authors.lastname: Li
authors.forename: J S
authors.initials: JS
authors.lastname: Chen
mesh_terms: D000701:Analgesics, Opioid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000701:Analgesics, Opioid; C017114:carfentanil; D005283:Fentanyl