Tightly linked flanking microsatellite markers for the Usher syndrome type I locus on the short arm of chromosome 11.
Usher syndrome type I is an autosomal recessive disease characterized by profound congenital hearing impairment and vestibular dysfunction followed by the onset of progressive pigmentary retinopathy in childhood or early adolescence. A locus (USH1C) for one form of this disease was previously assigned to the short arm of chromosome 11 through linkage studies in the Acadian population of southwestern Louisiana. Linkage analyses of a set of microsatellite markers in 27 Acadian families provide evidence that USH1C lies between D11S861 and D11S928. Three markers (D11S419, D11S921, and D11S899) that lie between the flanking markers show no recombination with USH1C, and all 54 chromosomes with the abnormal allele at the disease locus have identical alleles for D11S419 and D11S921. This haplotype was found on only 10 of 50 chromosomes with the normal allele at the disease locus, suggesting a strong founder effect. Of the 54 chromosomes with the abnormal allele, 12 had a divergent allele at D11S899. These results suggest that USH1C is in the 2-3-cM interval between D11S861 and D11S899.
Keats
B J
BJ
Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112.
Nouri
N
N
Pelias
M Z
MZ
Deininger
P L
PL
Litt
M
M
D002880:Chromosomes, Human, Pair 11; D004276:DNA, Satellite / Q000032:analysis; D003638:Deafness / Q000151:congenital / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008145:Louisiana; D010375:Pedigree; D011792:Quebec / Q000208:ethnology; D012174:Retinitis Pigmentosa / Q000235:genetics*; D013577:Syndrome
D004276:DNA, Satellite; D005819:Genetic Markers