Overexpression of p53 protein and c-erbB-2 protein in small cell carcinoma of the cervix uteri.
Twenty-eight primary small cell carcinomas of the cervix uteri were examined immunohistochemically for overexpression of p53 protein and c-erbB-2 protein. Twenty-one per cent of the cases showed positive immunostaining for p53 protein, whereas no staining was observed using the antibody against c-erbB-2. Our results indicate that altered expression of p53 protein may be involved in the development of small cell carcinoma of the cervix uteri.
Holm
R
R
Department of Pathology, Norwegian Radium Hospital, Oslo.
Abeler
V M
VM
Skomedal
H
H
Nesland
J M
JM
D014408:Biomarkers, Tumor / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000096:biosynthesis; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000096:biosynthesis; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53