Ca ions stabilize the binding of complement factor iC3b to the pseudohyphal form of Candida albicans.
The pseudohyphal form of Candida albicans is able to bind iC3b. This may play an important role in the pathogenesis of disseminated candidiasis and, in particular, in adherence to endothelium, protection against complement action, and iron acquisition from erythrocytes. Here we report that Ca2+ ions are required to maintain stable binding of iC3b to C. albicans pseudohyphae.
Spötl
L
L
Institut für Hygiene, Leopold-Franzens-Universität Innsbruck, Austria.
Möst
J
J
Dierich
M P
MP
D002118:Calcium / Q000494:pharmacology*; D002176:Candida albicans / Q000276:immunology / Q000472:pathogenicity*; D003179:Complement C3b / Q000378:metabolism*; D004492:Edetic Acid / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D003179:Complement C3b; D004492:Edetic Acid; D008274:Magnesium; D015032:Zinc; D002118:Calcium