Autoimmune anemia, neutropenia, Eaton-Lambert syndrome, and cerebellar degeneration in a patient with lymphoid hyperplasia.
We report a case of Coombs-positive anemia, neutropenia, Eaton-Lambert syndrome, and cerebellar degeneration with anti-Purkinje cell antibodies. No definitive cause has been established despite an extensive search for a malignancy or a known autoimmune disease. The histology of spleen and lymph nodes showed marked polyclonal B and T cell hyperplasia, noncaseating granulomas, and increased eosinophils. The disease failed to improve after splenectomy and treatment with prednisone and cyclophosphamide; partial response was achieved with azathioprine plus prednisone.
Storek
J
J
Department of Medicine, University of California School of Medicine, Los Angeles.
Kunkel
L A
LA
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000503:physiopathology; D005871:Castleman Disease / Q000175:diagnosis*; D004576:Electromyography; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000503:physiopathology; D008297:Male; D009503:Neutropenia / Q000150:complications* / Q000503:physiopathology