The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32.
Using both chromosomal in situ hybridization and molecular techniques, we report the genetic localization of the gene coding for the alpha 1 subunit of the skeletal slow Ca2+ current channel/DHP receptor gene (Cchl1a3) on human Chromosome (Chr) 1 (1q31-1q32 region) and on mouse Chr 1 (region (F-G)). On the basis of single-strand conformation polymorphism (SSCP-PCR) analysis in an interspecific backcross, we have determined that the Cchl1a3 = mdg (muscular dysgenesis) locus is very closely linked to the myogenin (Myog) locus.
Drouet
B
B
Groupe de Biologie, Développement et Régénération du Système Neuromusculaire, INSERM U. 153, Paris, France.
Garcia
L
L
Simon-Chazottes
D
D
Mattei
M G
MG
Guénet
J L
JL
Schwartz
A
A
Varadi
G
G
Pinçon-Raymond
M
M
D000818:Animals; D001483:Base Sequence; D001842:Bone and Bones / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism; D020746:Calcium Channels, L-Type; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003433:Crosses, Genetic; D017931:DNA Primers; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009115:Muridae; D009124:Muscle Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011950:Receptors, Cholinergic / Q000235:genetics* / Q000378:metabolism
D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D017931:DNA Primers; D009124:Muscle Proteins; D011950:Receptors, Cholinergic