title: Tissue reactions to subcutaneously implanted, surface-modified silicones.
abstract: To evaluate the influence of surface properties on tissue reactions, the surface of a medical-grade silicone elastomer was modified without changing the bulk properties. Surface modifications employed were oxidation by corona discharge in air, graft polymerization of water-soluble monomers, coating a polysaccharide through polyion complex formation, and covalent immobilization of cell-adhesive proteins. Surface-modified silicone sheets were implanted in the subcutaneous tissue of rats, and tissue reactions such as infiltration of inflammatory cells, appearance of foreign-body giant cells, and collagenous capsule formation were studied. It was found that the thickness of collagenous capsules formed after 16 weeks' implantation was in the range of 85-95 microns for the nontreated ones and all the modified silicones except the acrylic acid-grafted and the collagen-immobilized silicones.
authors.affiliation: Research Center for Biomedical Engineering, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D003238:Connective Tissue / Q000378:metabolism*; D003239:Connective Tissue Cells; D005549:Foreign-Body Reaction / Q000378:metabolism*; D015743:Giant Cells, Foreign-Body / Q000502:physiology; D007249:Inflammation / Q000378:metabolism; D019736:Prostheses and Implants; D051381:Rats; D013499:Surface Properties
chemical_list: D003094:Collagen