title: Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.
abstract: We describe the synthesis and characterization of novel phosphorothioate-methylphosphonate backbone-modified oligodeoxynucleotide co-polymers. These may have potential use as antisense constructs.
authors.affiliation: Pharmacology Department, Georgetown University Medical Center, Washington, DC 20007.
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: A M
authors.initials: AM
authors.lastname: Morocho
authors.forename: B C
authors.initials: BC
authors.lastname: Chen
authors.forename: J S
authors.initials: JS
authors.lastname: Cohen
mesh_terms: D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis*; D013873:Thionucleotides / Q000138:chemical synthesis*
chemical_list: D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D013873:Thionucleotides