Evaluation of two new liquid-liquid oxygenators.
The authors devised two liquid oxygenator units in which blood is directly oxygenated with oxygenated perfluorocarbon (PFC), a substance harmless to the blood that has a high specific gravity. 1) The droplet-type oxygenator unit is composed of a blood oxygenating chamber and a PFC oxygenating chamber. Blood is oxygenated by the infusion of PFC droplets into the blood oxygenating chamber; PFC is then spontaneously separated from the blood because of a difference in specific gravity, and reoxygenated in the PFC oxygenating chamber. Experimental results obtained using mongrel dogs indicated this oxygenator to have a high efficacy of oxygenation (Qp/Qt = 0.63-0.78 with blood flow of 450-300 ml, O2 Transfer Rate = 64 ml/min with blood flow of 300 ml), and high carbon dioxide discharge (delta CO2/PaCO2 = 0.07-0.13, CO2 Transfer Rate = 11 ml/min with blood flow of 300 ml). Pathology examination showed microthrombi containing PFC in the lung and liver. 2) The disk type oxygenator unit is composed of a cylinder and 18 rotors connected to an axle. Oxygenated PFC enters into the lower part of the oxygenator and mixes with venous blood flowing above the PFC layer. The rotation of the disk in the oxygenator causes the blood and PFC to mix. Experimental results obtained using mongrel dogs showed excellent O2 exchange (Qp/Qt = 0.48-0.83, O2 Transfer Rate = 52 ml/min with blood flow of 300 ml) and CO2 removal capacity (delta CO2/PaCO2 = 0.05-0.10, CO2 Transfer Rate = 9 ml/min at blood flow rate of 300 ml/min) for 2 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
Sueda
T
T
Department of Surgery, Hiroshima University, School of Medicine, Japan.
Fukunaga
S
S
Matsuura
Y
Y
Kajihara
H
H
D000818:Animals; D004285:Dogs; D005466:Fluorocarbons; D010106:Oxygenators; D011659:Pulmonary Gas Exchange
D005466:Fluorocarbons