title: Dopamine D3 receptor: basic and clinical aspects.
abstract: The recently discovered dopamine D3 receptor can be considered as a D2-like receptor: it is encoded by a gene comprising several introns; it is both an autoreceptor and a postsynaptic receptor, well recognized by antipsychotics. It differs, however, from the D2 receptor by a much more discrete expression, mostly in few limbic brain areas, e.g. shell of nucleus accumbens, islands of Calleja, and a considerably higher affinity for dopamine. Two association studies preliminarily suggest that the homozygotes for a D3 receptor gene polymorphism display twofold higher risk of schizophrenia, whereas several linkage studies led to inconclusive results.
authors.affiliation: Unité de Neurobiologie et Pharmacologie (U.109), INSERM, Centre Paul Broca, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Schwartz
authors.forename: D
authors.initials: D
authors.lastname: Levesque
authors.forename: M P
authors.initials: MP
authors.lastname: Martres
authors.forename: P
authors.initials: P
authors.lastname: Sokoloff
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D011954:Receptors, Dopamine / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3
chemical_list: D014150:Antipsychotic Agents; C493593:DRD3 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3