Comparative study of flow parameters of excipients for direct compression excipients determined using a ring shear.
In a previous research it has been attempted to define the selective criteria for excipients used in direct compression by measuring their flow rate and their flow regularity. The control of flowability of Avicel PH 101 and Cellutab has now been realized using a ring shear cell. A comparison of results obtained shows a different behavior in both excipients. In this way, we obtained higher values of cohesion and friction coefficients for Avicel PH 101 than for Cellutab, and values of flow factor that indicate good flow for Avicel PH 101 and excellent flow for Cellutab.
Velasco
M V
MV
Departemento de Farmacia y Technología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Spain.
Muñoz
A
A
Monedero
M C
MC
Jiménez-Castellanos
M R
MR
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients; D014783:Viscosity
D005079:Excipients