title: Single intraoperative applications of 5-fluorouracil during filtration surgery: early results.
abstract: Experimental studies from our laboratory have suggested that single exposures to 5-fluorouracil (5-FU) would have a similar effect to subconjunctival injections of 5-FU and a less permanent effect on subconjunctival fibroblasts than mitomycin C (MMC). Thirty four eyes of 33 glaucoma patients with an increased risk of filtration surgery failure were treated with a single intraoperative 5 minute exposure of sclera and subconjunctival tissues to 5-FU, 25 mg/ml. The follow up period ranged from 3-9 months, during which two high risk eyes failed completely and one required topical beta blockers to control intraocular pressure. No low/moderate risk eyes failed. Single 5 minute intraoperative exposures to 5-FU are convenient, inexpensive, have no significant corneal side effects, and may be a useful adjunctive treatment to optimise the results of glaucoma filtration surgery, particularly in the large group of low/moderate risk patients.
authors.affiliation: Moorfields Eye Hospital, London.
authors.forename: L
authors.initials: L
authors.lastname: Lanigan
authors.forename: J
authors.initials: J
authors.lastname: Stürmer
authors.forename: K A
authors.initials: KA
authors.lastname: Baez
authors.forename: R A
authors.initials: RA
authors.lastname: Hitchings
authors.forename: P T
authors.initials: PT
authors.lastname: Khaw
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002675:Child, Preschool; D005260:Female; D005374:Filtration; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D005472:Fluorouracil