Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs.
Aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF) in guinea pigs was used as a marker of bronchial inflammation. Drugs were administered orally 4 h after aeroallergen challenge. Allergic bronchial eosinophilia in guinea pigs was inhibited by orally administered dexamethasone and methylprednisolone. Terfenadine (a newer H1-receptor antagonist), theophylline (a nonspecific phosphodiesterase inhibitor), and salbutamol (a beta 2-agonist) did not influence allergic eosinophilic infiltration. Many of these agents, administered prophylactically, have been reported to suppress allergic eosinophilic infiltration in the BALF of guinea pigs. Methylprednisolone, a steroid, inhibits allergic bronchial eosinophilia regardless of the time of administration; that is, 2 h before or 4 h after aeroallergen challenge. The therapeutic approach used in this study may facilitate drug discovery for bronchial inflammation/asthma.
Chand
N
N
Department of Pharmacology, Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, NJ 08512.
Harrison
J E
JE
Rooney
S M
SM
Nolan
K W
KW
De Vine
C L
CL
Jakubicki
R G
RG
Pillar
J
J
Diamantis
W
W
Sofia
R D
RD
D000420:Albuterol / Q000627:therapeutic use; D000485:Allergens / Q000008:administration & dosage; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003907:Dexamethasone / Q000627:therapeutic use; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D004802:Eosinophilia / Q000188:drug therapy* / Q000473:pathology; D004804:Eosinophils / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010047:Ovalbumin / Q000276:immunology; D016593:Terfenadine / Q000627:therapeutic use; D013806:Theophylline / Q000627:therapeutic use
D000485:Allergens; D000893:Anti-Inflammatory Agents; D016593:Terfenadine; D003907:Dexamethasone; D010047:Ovalbumin; D013806:Theophylline; D000420:Albuterol; D008775:Methylprednisolone