Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
Sangeeta
Department of Pharmacology & Therapeutics, Govt. Medical College, Jammu Tawi.
Raina
R K
RK
Bano
G
G
D000042:Absorption; D000328:Adult; D003692:Delayed-Action Preparations; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D004435:Eating / Q000502:physiology; D005215:Fasting; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D013806:Theophylline / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D013806:Theophylline