[Increase in spontaneous growth hormone secretion in asthmatic children--a symptom of atopic disposition?].
BACKGROUND
Asthmatic children tend towards hyposomia. Although quite a number of suggestions have been made, the real cause of this phenomenon has not yet been revealed. Investigation of the growth hormone secretion and the IGF-I serum levels aims at clarifying whether an atopy-caused disturbance in the interaction between both the hormones is responsible for retardations in the growth and development of asthmatic children.


METHODS
In 19 prepubertal extrinsic asthmatics the spontaneous growth hormone secretion was reviewed in form of a 24 h-profile. In addition, the IGF-I serum levels were measured.


RESULTS
With a mean 24 h-secretion of 10.7 +/- 1.0 ng/ml and a maximum growth hormone peak of 39.5 +/- 5.8 ng/ml prepubertal extrinsic asthmatics showed an increased hormone secretion which, however, could not be observed with all the children. The IGF-I mean values were in 11 asthmatics within the normal range, decreased in 5 cases and increased in only 3 children.
Baum
W F
WF
Kinderklinik, Martin-Luther-Universität Halle.
Klöditz
E
E
Hesse
V
V
Jahreis
G
G
Schneyer
U
U
Giebler
H
H
D000293:Adolescent; D001249:Asthma / Q000097:blood*; D001827:Body Height / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D012016:Reference Values; D012130:Respiratory Hypersensitivity / Q000097:blood*; D012894:Sleep Stages / Q000502:physiology
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
Steigerung der spontanen Wachstumshormon-Sekretion bei asthmakranken Kindern--Ein Symptom der atopischen Disposition?