The human paired domain gene PAX7 (Hup1) maps to chromosome 1p35-1p36.2.
The human PAX7 gene encodes a protein containing a domain homologous to the Drosophila paired box first described in three segmentation genes. In addition to the paired box, the gene contains the conserved octapeptide and a paired-type homeobox. Two of the five known human PAX genes have been implicated in human disorders so far. Here we have used a somatic cell hybrid panel to localize PAX7 to human chromosome 1. In situ hybridization shows that PAX7 is confined to the short arm of chromosome 1 at 1p35-1p36.2.
Schäfer
B W
BW
University of Zurich, Department of Pediatrics, Switzerland.
Mattei
M G
MG
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006224:Cricetinae; D004330:Drosophila / Q000235:genetics; D005796:Genes; D005801:Genes, Homeobox; D018398:Homeodomain Proteins; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009928:Organ Specificity; D051763:PAX7 Transcription Factor; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D018398:Homeodomain Proteins; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D051763:PAX7 Transcription Factor; C497321:PAX7 protein, human; C497322:Pax7 protein, mouse