Possible involvement of endothelin in thromboxane A2 receptor agonist (U-46619)-induced angina in the rat.
The thromboxane A2 receptor agonist, U-46619 ((5Z, 9 alpha, 11 alpha, 13E, 15(S))-9,11-(methanoepoxy)prosta-5,13-dien-1-oic acid) (10 micrograms/kg), induced a typical ischemic change (ST elevation) in the electrocardiogram on intracoronary arterial administration in the rat. The elevation of the ST segment induced by U-46619 was significantly reduced by pretreatment with anti-endothelin-1 rabbit serum. The plasma concentration of endothelin-1 dose dependently increased at the time of ST segment elevation after U-46619. These results indicate that endogenous endothelin-1 partly contributes to coronary spasmodic angina induced by thromboxane A2 in rats.
Yamamoto
T
T
Department of Pharmacology, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
Hosoki
K
K
Karasawa
T
T
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000787:Angina Pectoris / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D004562:Electrocardiography / Q000187:drug effects; D016232:Endothelins / Q000097:blood / Q000502:physiology*; D007269:Injections, Intra-Arterial; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000503:physiopathology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000633:toxicity*; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013928:Thromboxane A2 / Q000031:analogs & derivatives* / Q000633:toxicity; D014662:Vasoconstrictor Agents / Q000633:toxicity*
D016232:Endothelins; D011450:Prostaglandin Endoperoxides, Synthetic; D014662:Vasoconstrictor Agents; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid