Pregnancy after liver transplantation.
Two patients who became pregnant after liver transplantation for end-stage liver disease were carefully monitored using pulsed Doppler waveform measurements. One patient with Wilson's disease, on triple immunosuppressive therapy including prednisone, azathioprine and low-dose cyclosporin A, delivered a healthy girl weighing 2650 g after 38 weeks' gestation. The other patient, with HBV-related postnecrotic cirrhosis, became pregnant less than 3 months postoperatively, under triple therapy, after being amenorrheic for 6 years. Episodes of elevation in liver enzymes were noted, and severe osteoporosis with low back pain developed. A healthy boy weighing 2975 g was born at 35 weeks' gestation. Our cases add to previous reports of successful pregnancies under cyclosporin A immunosuppression.
Baruch
Y
Y
Department of Medicine B, Rambam Medical Center, Haifa, Israel.
Weiner
Z
Z
Enat
R
R
Ronen
N
N
Blumenfeld
Z
Z
D000328:Adult; D001379:Azathioprine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D001783:Blood Flow Velocity; D016572:Cyclosporine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation; D011182:Postoperative Care; D011241:Prednisone / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy / Q000187:drug effects / Q000502:physiology*; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000187:drug effects; D014599:Uterus / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects
D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone