title: Long-term intraocular pressure control by trabeculectomy: a ten-year life table.
abstract: A retrospective study of 179 eyes in 127 patients who underwent trabeculectomy at Sydney Eye Hospital under the supervision of two surgeons between 1977 and 1982 was carried out. Survival analysis by life table method shows cumulative two, five, and 10 year success rates to be 78%, 70%, and 67% respectively, with mean duration of intraocular pressure control (IOP < 21 mmHg) being 88 months. Antiglaucoma medication improved the long-term survival significantly (Hazard Ratio of 0.49 and P = 0.01) so that when the definition for failure is taken as IOP > 20 mmHg while using medication, the two, five and 10 year success rates were 89%, 87% and 86% respectively. A rise in average intraocular pressure is seen between two weeks and three months after trabeculectomy. The improvement in long-term success rate with use of topical steroids was suggestive (Hazard Ratio of 0.69) but not conclusive (P = 0.21). No difference was found in survival comparing fornix versus limbal based flap technique.
authors.affiliation: Sydney Eye Hospital, Sir John Young Crescent, Woolloomooloo, NSW.
authors.forename: D I
authors.initials: DI
authors.lastname: Robinson
authors.forename: S
authors.initials: S
authors.lastname: Lertsumitkul
authors.forename: F A
authors.initials: FA
authors.lastname: Billson
authors.forename: L P
authors.initials: LP
authors.lastname: Robinson
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects; D015993:Life Tables; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000453:epidemiology / Q000517:prevention & control*; D012189:Retrospective Studies; D016019:Survival Analysis; D014130:Trabeculectomy
chemical_list: D000319:Adrenergic beta-Antagonists; D005938:Glucocorticoids