[Cytokines and immune response].
This review paper briefly describes the principal cytokines involved in immune response, and in particular their role in some of its key-steps: antigen presentation; activation, proliferation and differentiation of CD4+ T cell subsets; antibody response by B cells; manifestations of hypersensitivity. The role played by cytokines in cytotoxic T cell (CTL) differentiation and in T cell-mediated suppression phenomena is also discussed. It seems that the auxiliary CD4+ memory cells secrete either IL-2 and interferon gamma (Th1) or IL-4 and IL-5 (Th2). It has recently been suggested that cytotoxic/suppressor CD8+ cells can also be divided into cells that secrete interferon gamma and no IL-4 (CTL) and cells that secrete IL-4 and IL-5 (suppressor T cells). The reciprocal regulatory effects of these cell populations through these interleukins is also discussed.
Pelletier
L
L
INSERM U28, hôpital Broussais, Paris.
Bellon
B
B
Druet
P
P
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology*; D007378:Interleukins / Q000276:immunology
D016207:Cytokines; D007378:Interleukins
Cytokines et réponse immune.