title: Topical treatment of acute sprains.
abstract: In a randomised, placebo-controlled, double-blind study with parallel group comparison, the efficacy and tolerability of topical treatment with a mucopolysaccharide polysulphate/salicylic acid cream was investigated in 156 patients with acute sprains of the knee or ankle joint. There was a more rapid reduction in pain on movement (the main parameter) in the active drug group compared with the placebo group. On day 9 after randomisation the difference was highly significant. There were no adverse events in the active drug group.
authors.affiliation: Biometrical Department, Luitpold Pharma, Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Frahm
authors.forename: U
authors.initials: U
authors.lastname: Elsasser
authors.forename: A
authors.initials: A
authors.lastname: Kämmereit
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D016512:Ankle Injuries / Q000188:drug therapy*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D006854:Hydrocortisone; D007718:Knee Injuries / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012459:Salicylates / Q000008:administration & dosage*; D013180:Sprains and Strains / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009824:Ointments; D012459:Salicylates; C019018:movelat; D006493:Heparin; D006854:Hydrocortisone