title: A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine.
abstract: A high performance liquid chromatographic method to measure plasma and urine fenoprofen levels in equine biofluids is described. Liquid-liquid extraction with diethylether was used to isolate the drug from plasma and urine. The accuracy and reproducibility of the method were within acceptable limits over the concentration range 0-10 micrograms/mL and 0-20 micrograms/mL respectively from plasma and urine. Detection limits were 0.05 microgram/mL (2 mL plasma) and 0.2 microgram/mL (0.5 mL urine). This procedure was applied to ascertain the pharmacokinetics of a 3 g dose of fenoprofen calcium in a horse.
authors.affiliation: Faculteit Diergeneeskunde, Universiteit Gent, Belgium.
authors.forename: F T
authors.initials: FT
authors.lastname: Delbeke
authors.forename: M
authors.initials: M
authors.lastname: Debackere
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000592:standards; D005260:Female; D005279:Fenoprofen / Q000097:blood* / Q000652:urine*; D006736:Horses / Q000097:blood* / Q000652:urine*; D015203:Reproducibility of Results
chemical_list: D005279:Fenoprofen