Vitamin E uptake into the brain and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.
The brain uptake index for vitamin E has not been reported previously. This study examined the possible involvement of altered brain vitamin E uptake as an explanation of alterations in vitamin E levels in the brain following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. The brain uptake index of vitamin E was evaluated in control mice and at 1 and 24 h after toxin treatment. Control mice had a brain uptake index of 6.1 +/- 1.2. The toxin induced more than a twofold increase in the vitamin E brain uptake index to 15.2 +/- 6.8 at 1 h after treatment, which returned to control values at 24 h. The dramatic increase in the brain uptake index of vitamin E may explain the increases in vitamin E levels found in some brain regions following MPTP administration.
Adams
J D
JD
Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, Los Angeles 90033.
Wang
B
B
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012016:Reference Values; D014810:Vitamin E / Q000493:pharmacokinetics*
D014810:Vitamin E