The study of histamine H1- and H2-receptors in human lung cancer.
Data on human lung histamine H1- and H2-receptors in cancer and chronic inflammatory processes are reported. It has been found that the number of histamine H1-receptors significantly increases both in cancer and chronic pneumonia and does not practically change in tuberculosis lung parenchyma. The binding parameters of histamine H2-receptors both in cancer and inflammatory processes were similar to those obtained for the normal tissue. The important role of parenchymal histamine H1-receptors in the neuromodulation of airways in human lung adenocarcinoma is discussed.
Kondratenko
T Y
TY
Research Center of Molecular Diagnostics and Therapy, Moscow, Russia.
Zacharova
I V
IV
Katukov VYu
Kuzina
N V
NV
Severin
E S
ES
Kornilova
Z Ch
ZCh
Perelman
M I
MI
D000230:Adenocarcinoma / Q000737:chemistry* / Q000150:complications / Q000503:physiopathology; D000328:Adult; D000402:Airway Obstruction / Q000209:etiology / Q000503:physiopathology; D002908:Chronic Disease; D002927:Cimetidine / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis* / Q000502:physiology; D011014:Pneumonia / Q000378:metabolism; D011738:Pyrilamine / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000032:analysis* / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000032:analysis* / Q000502:physiology; D014375:Tuberculoma / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000378:metabolism
D009363:Neoplasm Proteins; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002927:Cimetidine; D011738:Pyrilamine