Neurotensin and oxyntomodulin-(30-37) potentiate PYY regulation of gastric acid and somatostatin secretions.
The present study was designed to investigate, in cats provided with both a gastric fistula and a denervated fundic Heidenhain pouch, the effect of peptide YY (PYY) on pentagastrin-stimulated gastric acid and somatostatin secretions and to determine whether neurotensin (NT) and the COOH-terminal octapeptide of oxyntomodulin [Oxm-(30-37)] would modify these secretions. Intravenous infusion of PYY (0.1 nmol.kg-1.h-1), NT (15 nmol.kg-1.h-1), or Oxm-(30-37) (60 nmol.kg-1.h-1) did not affect basal acid secretion. However, they significantly inhibited pentagastrin-stimulated gastric acid output up to 50% (P < 0.01) in the main stomach. Furthermore, they significantly increased gastric somatostatin release by +750, +1,700, and +600% over basal level (P < 0.01) for (in nmol.kg-1.h-1) 0.1 PYY, 15 NT, and 60 Oxm-(30-37), respectively. On the other hand, the effects of 0.1 nmol.kg-1.h-1 PYY were potentiated by subthreshold doses of NT (5 nmol.kg-1.h-1) or Oxm-(30-37) (15 nmol.kg-1.h-1). These findings suggest that there could be a cooperation between the three peptides in the intestinal regulation of gastric secretions.
Bado
A
A
Institut National de la Santé et de la Recherche Médicale Unité de Gastroentérologie U10, Hôpital Bichat, Paris, France.
Cloarec
D
D
Moizo
L
L
Laigneau
J P
JP
Bataille
D
D
Lewin
M J
MJ
D000818:Animals; D002415:Cats; D004357:Drug Synergism; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000502:physiology; D004763:Glucagon-Like Peptides / Q000494:pharmacology*; D009496:Neurotensin / Q000494:pharmacology*; D053772:Oxyntomodulin; D010418:Pentagastrin / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D019894:Peptide YY; D010455:Peptides / Q000502:physiology*; D013004:Somatostatin / Q000378:metabolism*
D005768:Gastrointestinal Hormones; D053772:Oxyntomodulin; D010446:Peptide Fragments; D010455:Peptides; D019894:Peptide YY; D009496:Neurotensin; D013004:Somatostatin; D004763:Glucagon-Like Peptides; D010418:Pentagastrin