title: Inhaled nitric oxide in patients with normal and increased pulmonary vascular resistance after cardiac surgery.
abstract: We studied the haemodynamic effects of inhaled nitric oxide 40 p.p.m. in two groups of patients after cardiac surgery (mitral valve surgery or coronary artery bypass grafting). Nitric oxide caused a significant reduction in pulmonary vascular resistance after mitral valve surgery in patients who had pre-existing pulmonary hypertension, but no change in haemodynamic state in the coronary artery bypass group of patients, who had normal pulmonary arterial pressures.
authors.affiliation: Department of Anaesthesia, Papworth Hospital, Cambridge.
authors.forename: D J
authors.initials: DJ
authors.lastname: Snow
authors.forename: S J
authors.initials: SJ
authors.lastname: Gray
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: L
authors.initials: L
authors.lastname: Foubert
authors.forename: A
authors.initials: A
authors.lastname: Oduro
authors.forename: T W
authors.initials: TW
authors.lastname: Higenbottam
authors.forename: F C
authors.initials: FC
authors.lastname: Wells
authors.forename: R D
authors.initials: RD
authors.lastname: Latimer
mesh_terms: D000280:Administration, Inhalation; D001026:Coronary Artery Bypass; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D008943:Mitral Valve / Q000601:surgery; D009569:Nitric Oxide / Q000494:pharmacology*; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D009569:Nitric Oxide