Toxic oil syndrome: a study of renal function in guinea pigs fed toxic oil.
1. Comparative studies of beta-N-acetylglucosaminidase (NAG, EC 3.2.1. 52) and beta-galactosidase (EC 3.2.1. 23) activities, protein concentration and creatinine clearance, were carried out in urine and kidney from guinea pigs treated with "toxic oil", orally administered under different conditions, related to controls. 2. Enzyme activities did not vary significantly in urine with any of the studied conditions of oil administration. By contrast, in kidney, beta-D-galactosidase disclosed a significant increase in all the treatments studied when compared to controls without treatment. 3. Urinary protein excretion, creatinine concentration and creatinine clearance were significantly greater in treated animals than in controls after 4 weeks of treatment. 4. Relative kidney weight (g/100 g body wt), was significantly lower in animals treated for 28 days with previously heated oil.
Sánchez-Bernal
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Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Salamanca, Spain.
Sánchez-Martín
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M
Sánchez Llorente
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A
Cabezas
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JA
Pérez González
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N
D000118:Acetylglucosaminidase / Q000378:metabolism* / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D001937:Brassica; D003404:Creatinine / Q000652:urine; D005229:Fatty Acids, Monounsaturated; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced*; D000074262:Rapeseed Oil; D013577:Syndrome; D001616:beta-Galactosidase / Q000378:metabolism* / Q000652:urine
D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D003404:Creatinine; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase