4',6-Diamidino 2-phenylindole is a new reversible inhibitor of diamine oxidase and S-adenosyl-L-methionine decarboxylase from mammalian tissues.
1. 4',6-Diamidino-2-phenylindole is a powerful reversible inhibitor of porcine kidney diamine oxidase and partially purified rabbit liver S-adenosyl-L-methionine decarboxylase. 2. This diamidine has shown to be a competitive inhibitor of porcine kidney diamine oxidase with a Ki value of 13 microM. 3. A similar inhibitory pattern has been found on rat liver S-adenosyl-L-methionine decarboxylase with an estimated Ki of 21 microM.
Cubría
C
C
Departamento de Fisiología, Farmacología y Toxicología, Universidad de León, Spain.
Alvarez-Bujidos
M
M
Negro
A
A
Balaña-Fouce
R
R
Ordóñez
D
D
D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors*; D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D007364:Intercalating Agents / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D011817:Rabbits / Q000378:metabolism*; D013552:Swine
D007211:Indoles; D007364:Intercalating Agents; C007293:DAPI; D006631:Amine Oxidase (Copper-Containing); D012437:Adenosylmethionine Decarboxylase