Adrenoceptor subtypes mediating catecholamine-induced thermogenesis in man.
The sympathetic nervous system plays an important role in energy metabolism. This review deals with the type of adrenoceptors involved in catecholamine-induced thermogenesis. In healthy lean males, both beta 1- and beta 2-adrenoceptors are involved in sympathetically-mediated thermogenesis, whereas alpha-adrenoceptors probably do not play an important role. Although there seem to be no firm data to support the involvement of beta 3-adrenoceptors in human energy metabolism, conclusive evidence to exclude a significant role of beta 3-adrenoceptors in man is also lacking. In normal weight man, skeletal muscle is an important site of localization for sympathetically-mediated thermogenesis, but a contribution of other tissues, such as adipose tissue, cannot be excluded.
Blaak
E E
EE
Department of Human Biology, University of Limburg, Maastricht, The Netherlands.
Saris
W H
WH
van Baak
M A
MA
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002395:Catecholamines / Q000494:pharmacology* / Q000502:physiology; D004734:Energy Metabolism; D006801:Humans; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology
D002395:Catecholamines; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta