title: Treating periodontal diseases by blocking tissue-destructive enzymes.
abstract: A new therapeutic approach involves the discovery by the "Stony Brook group," that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.
authors.affiliation: Department of Oral Biology and Pathology, School of Dental Medicine, SUNY at Stony Brook 11794-8700.
authors.forename: L M
authors.initials: LM
authors.lastname: Golub
authors.forename: M
authors.initials: M
authors.lastname: Wolff
authors.forename: S
authors.initials: S
authors.lastname: Roberts
authors.forename: H M
authors.initials: HM
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Leung
authors.forename: G S
authors.initials: GS
authors.lastname: Payonk
mesh_terms: D005883:Gingival Crevicular Fluid / Q000201:enzymology; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000201:enzymology*; D010514:Periodontal Pocket / Q000201:enzymology; D013752:Tetracycline / Q000627:therapeutic use; D013754:Tetracyclines / Q000627:therapeutic use*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D013754:Tetracyclines; C053450:4-des-dimethylaminotetracycline; D008666:Metalloendopeptidases; D013752:Tetracycline