Human leukocyte antigen in hydatidiform mole.
OBJECTIVE
To find any possible association between human leukocyte antigen (HLA) as a genetic marker and the development of hydatidiform mole (HM).


METHODS
The lymphocyte microtoxicity technique was used to study the HLA antigens in 3 groups: 18 women with hydatidiform mole and their husbands (study group), 300 normal women (first control group), and 20 normal pregnant women and their husbands (second control group).


RESULTS
Hydatidiform mole is more frequent in women having HLA A1. The disease is more common in couples with partial compatibility of the B locus.


CONCLUSIONS
HM occurs more frequently in women with certain HLA antigens and when the husband and wife have partial compatibility at the B locus.
Souka
A R
AR
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt.
Kholeif
A
A
Zaki
S
S
Rocca
M
M
Ghanem
I
I
D016022:Case-Control Studies; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005819:Genetic Markers; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000276:immunology; D008285:Major Histocompatibility Complex; D008297:Male; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000235:genetics* / Q000276:immunology
D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens