An absence of changes in sigma receptor subtypes in the brains of genetically dystonic (dt) rats.
Binding sites for the sigma ligand [3H]di-o-tollylguanidine ([3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective sigma 1 and sigma 2 assay conditions were utilized in an effort to define which subpopulation of [3H]DTG binding sites is altered in the dystonic strain (dt). Both this approach and a re-examination using conditions similar to the previous report failed to confirm a difference between the brains of dystonic and normal rats in terms of sigma binding. Although not directly negating the possible involvement of sigma receptors in dystonia, these results indicate that sigma 1 and sigma 2 receptors appear unchanged in dystonic rats.
Weissman
A D
AD
Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD.
McCann
D J
DJ
Lorden
J F
JF
Su
T P
TP
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D004421:Dystonia / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006146:Guanidines / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011922:Rats, Mutant Strains; D017480:Receptors, sigma / Q000235:genetics*
D006146:Guanidines; D017480:Receptors, sigma; C050232:1,3-ditolylguanidine