title: [Sodium oxybutyrate normalizes the central nervous system functions in the progeny of rats subjected to hypobaric hypoxia during pregnancy].
abstract: Two-hour hypobaric hypoxia of rats on day 15 of their pregnancy led to a reduction in weight gain of pups within 20 days after birth, disturbed memory in active and passive paradigms, changed adaptive behavior in the extrapolatory water avoidance test, and impaired sleep in adult animals. Postnatal treatment with sodium hydroxybutyrate given in a dose of 50 mg/kg/day on days 8 to 20 of life normalized mnestic functions of the brain, the process of falling asleep, and physical development which had been impaired by intrauterine hypoxia.
authors.forename: S S
authors.initials: SS
authors.lastname: Trofimov
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaia
authors.forename: N M
authors.initials: NM
authors.lastname: Smol'nikova
authors.forename: E V
authors.initials: EV
authors.lastname: Kravchenko
authors.forename: O A
authors.initials: OA
authors.lastname: Kutepova
authors.forename: N A
authors.initials: NA
authors.lastname: Bondarenko
authors.forename: L N
authors.initials: LN
authors.lastname: Nerobkova
authors.forename: E P
authors.initials: EP
authors.lastname: Nemova
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000818:Animals; D001273:Atmosphere Exposure Chambers; D002490:Central Nervous System / Q000187:drug effects* / Q000503:physiopathology; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008568:Memory / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D012978:Sodium Oxybate
vernacular_title: Natriia oksibutirat mormalizuet funktsii tsentral'noĭ nervnoĭ sistemy u potomstva krys, podvergshikhsia gipobaricheskoĭ gipoksii vo vremia beremennosti.