title: Relationship between chimpanzee Rh-like genes and the R-C-E-F blood group system.
abstract: The antigenic closeness between the chimpanzee alloantigen Rc of the R-C-E-F system, and the human alloantigen Rho(D) suggests a phyloge-connection between their genes. To confirm at the molecular level the common origin of these genes, genomic DNA from 16 unrelated chimpanzees of various R-C-E-F phenotypes were digested by three restriction enzymes and analyzed by Southern blot using a human Rh cDNA probe and three exon-specific probes. Restrictions profiles displayed reach polymorphism. Correlations between some bands and certain R-C-E-F phenotypes demonstrate that the human Rh cDNA probe defines in chimpanzee genomic DNA some genes of the R-C-E-F system.
authors.affiliation: Centre Régional de Transfusion Sanguine, CHU Purpan, Toulouse, France.
authors.forename: I
authors.initials: I
authors.lastname: Salvignol
authors.forename: A
authors.initials: A
authors.lastname: Blancher
authors.forename: P
authors.initials: P
authors.lastname: Calvas
authors.forename: W W
authors.initials: WW
authors.lastname: Socha
authors.forename: Y
authors.initials: Y
authors.lastname: Colin
authors.forename: J P
authors.initials: JP
authors.lastname: Cartron
authors.forename: J
authors.initials: J
authors.lastname: Ruffié
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001789:Blood Group Antigens / Q000235:genetics*; D015342:DNA Probes; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII; D006801:Humans; D002679:Pan troglodytes / Q000097:blood* / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012204:Rh-Hr Blood-Group System / Q000235:genetics*; D013045:Species Specificity
chemical_list: D001789:Blood Group Antigens; D015342:DNA Probes; D018076:DNA, Complementary; D012204:Rh-Hr Blood-Group System; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII