title: IgM and IgA rheumatoid factors in canine polyarthritis.
abstract: IgM and IgA rheumatoid factor (RF) were detected by ELISA using a purified dog IgG as antigen in normal controls (N = 84), dogs with unclassified polyarthritis (N = 95), dogs with rheumatoid arthritis (RA) (N = 22), dogs with systemic lupus erythematosus (SLE) (N = 35), dogs with leishmaniasis or heart worm disease (N = 20) and dogs with pyometra (N = 16). Frequency and titre of IgM and IgA RF are low and comparable (P < 0.05) in dogs with unclassified polyarthritis or RA: respectively 24.2% and 27.3% for IgM RF and 21.0% and 18.2% for IgA RF; the mean titre being respectively 0.781 +/- 0.581 and 0.649 +/- 0.365 for IgM RF, and 0.774 +/- 1.331 and 0.740 +/- 1.169 for IgA RF. The frequencies of IgM and IgA RF are a little higher in dogs with SLE (IgM RF: 37.1%, IgA RF: 25.7%) and higher in dogs with leishmaniasis or heart worm disease (45.0% and 30.0%), especially in dogs with pyometra (68.7% and 37.5%). So, although dogs can produce IgM and IgA RF, these auto-antibodies are uncommon in dogs with RA. Furthermore, when RF are present their titre is much lower than in human RA.
authors.affiliation: Laboratoire d'Immunopathologie, Ecole Vétérinaire de Lyon, Marcy l'Etoile, France.
authors.forename: L
authors.initials: L
authors.lastname: Chabanne
authors.forename: C
authors.initials: C
authors.lastname: Fournel
authors.forename: J R
authors.initials: JR
authors.lastname: Faure
authors.forename: C M
authors.initials: CM
authors.lastname: Veysseyre
authors.forename: D
authors.initials: D
authors.lastname: Rigal
authors.forename: J P
authors.initials: JP
authors.lastname: Bringuier
authors.forename: J C
authors.initials: JC
authors.lastname: Monier
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D007070:Immunoglobulin A / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007841:Latex Fixation Tests / Q000662:veterinary; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000662:veterinary; D008297:Male; D011528:Protozoan Infections / Q000276:immunology; D011529:Protozoan Infections, Animal; D012217:Rheumatoid Factor / Q000276:immunology*; D014591:Uterine Diseases / Q000276:immunology / Q000662:veterinary
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D012217:Rheumatoid Factor