title: Intraperitoneal local anaesthetics after laparoscopic cholecystectomy: effects on postoperative pain, metabolic responses and lung function.
abstract: We have compared the efficacy of 0.9% NaCl 20 ml (n = 15), 0.25% bupivacaine 20 ml (n = 15) and 0.5% lignocaine 20 ml (n = 15), administered i.p., in reducing postoperative pain and opioid requirements, and modifying the metabolic response to surgery and postoperative lung function after laparoscopic cholecystectomy. There were no differences in postoperative pain scores (visual analogue scale and verbal rating scale) between the three groups in the first 4 h after operation and in analgesic requirements during the first 24 h. In all groups, forced vital capacity, peak expiratory flow and forced expiratory volume in 1 s decreased 2 h after surgery (P < 0.001). Ventilatory values recovered only partially in the first 2 days after operation (P < 0.05), with no significant differences between groups. Plasma concentrations of glucose and cortisol increased after surgery (P < 0.05). Cortisol concentrations returned to baseline 48 h after operation. There were no significant differences between the groups in any measured variable. These data suggest that the administration of 20 ml of local anaesthetics i.p. is not effective in reducing postoperative pain, improving lung function, or attenuating the metabolic endocrine response after laparoscopic cholecystectomy.
authors.affiliation: Department of Anaesthesiology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: B M
authors.initials: BM
authors.lastname: Rademaker
authors.forename: C J
authors.initials: CJ
authors.lastname: Kalkman
authors.forename: J A
authors.initials: JA
authors.lastname: Odoom
authors.forename: L
authors.initials: L
authors.lastname: de Wit
authors.forename: J
authors.initials: J
authors.lastname: Ringers
mesh_terms: D000328:Adult; D000368:Aged; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis*; D017081:Cholecystectomy, Laparoscopic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007274:Injections, Intraperitoneal; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D001786:Blood Glucose; D006854:Hydrocortisone