[Rubomycin-induced cardiomyopathy in rats and the potential for therapy with a peptide preparation from the heart].
The study has shown the efficiency of heart peptide preparation (HP) in the management of rubomycin cardiomyopathy. HP does not prevent rat mortality if rubomycin doses are very large, but it can improve a state of survived animals. HP affects restoration processes in myocardium improving the myocardial contractibility.
Andreeva
L I
LI
Khavinson
V Kh
VKh
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D003630:Daunorubicin / Q000008:administration & dosage / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D010455:Peptides; D003630:Daunorubicin
Rubomitsinovaia kardiomiopatiia u krys i vozmozhnost' terapii peptidnym preparatom iz serdtsa.