title: [Synthesis and biological properties of delta-sleep peptide analogs. 2. Antimetastatic effect].
abstract: With the aim to investigate structure-functional relations of DSIP, 11 DSIP analogues were tested on antimetastatic activity, among them five new analogues, differing in positions 2 and 6 of the DSIP amino acid sequence were synthesized by the solid-phase method using Fmoc-approach. Experiments on C57B1 mice with metastatic Lewis lung carcinoma showed some analogues to be more efficient as antimetastatic agents then DSIP after i.v. (50 micrograms/kg) administration. Normalization of neuroendocrine status and activity of peritoneal, alveolar and spleen macrophages after the DSIP and some analogues injections in mice with metastatic Lewis lung carcinoma took place. Antimetastatic action of DSIP derivatives is considerably affected by structural changes, especially in the N-terminal part. Conformational factors rather than enhanced enzymatic resistance are essential for antimetastatic response.
authors.forename: I A
authors.initials: IA
authors.lastname: Prudchenko-
authors.forename: L V
authors.initials: LV
authors.lastname: Stashevskaia
authors.forename: E N
authors.initials: EN
authors.lastname: Shepel'
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
authors.forename: V T
authors.initials: VT
authors.lastname: Ivanov
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Shmal'ko
authors.forename: A P
authors.initials: AP
authors.lastname: Chalyĭ
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Umanskiĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Grinzhevskaia
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D008175:Lung Neoplasms / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D013329:Structure-Activity Relationship
chemical_list: D003701:Delta Sleep-Inducing Peptide
vernacular_title: Sintez i biologicheskie svoĭstva analogov peptida del'ta-sna. 2. Antimetastaticheskoe deĭstvie.