title: Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.
abstract: Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a clock mutation, timeless (tim), is described that produces arrhythmia for both behaviors. The effects of tim on behavioral rhythms are likely to involve products of the X chromosome-linked clock gene period (per), because tim alters circadian oscillations of per RNA. Genetic mapping places tim on the left arm of the second chromosome between dumpy (dp) and decapentaplegic (dpp).
authors.affiliation: Howard Hughes Medical Institute, National Science Foundation Science and Technology Center for Biological Timing, Rockefeller University, New York, NY 10021.
authors.forename: A
authors.initials: A
authors.lastname: Sehgal
authors.forename: J L
authors.initials: JL
authors.lastname: Price
authors.forename: B
authors.initials: B
authors.lastname: Man
authors.forename: M W
authors.initials: MW
authors.lastname: Young
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics*; D002874:Chromosome Mapping; D002940:Circadian Rhythm / Q000235:genetics*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D017344:Genes, Insect; D008675:Metamorphosis, Biological; D009043:Motor Activity; D016254:Mutagenesis, Insertional; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D056950:Period Circadian Proteins; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins; D012333:RNA, Messenger