Both neurotoxin II from venom of Naja naja oxiana and its endogenous analogue induce apoptosis in tumor cells.
Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues significantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apoptosis in L929 and K562 cells.
Strizhkov
B N
BN
Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Blishchenko EYu
Satpaev
D K
DK
Karelin
A A
AA
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003039:Cobra Neurotoxin Proteins / Q000737:chemistry / Q000633:toxicity*; D003553:Cystine / Q000737:chemistry; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D013552:Swine; D014407:Tumor Cells, Cultured
D003039:Cobra Neurotoxin Proteins; D009419:Nerve Tissue Proteins; D003553:Cystine; C076649:neurotoxin II, Naja naja oxiana