title: Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma.
abstract: We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.
authors.affiliation: First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: E
authors.initials: E
authors.lastname: Amemiya
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Suguro
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: A
authors.initials: A
authors.lastname: Yachi
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood; D018799:Intercellular Adhesion Molecule-1; D008875:Middle Aged
chemical_list: D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1