Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies.
We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Lewy body variant [LBV]), and normal controls. Dopamine and homovanillic acid (HVA) were severely depleted in basal ganglia of the LBV cases but were not significantly altered in pure AD cases; tyrosine hydroxylase levels in putamen were also significantly reduced in LBV but not AD cases. These reductions in basal ganglia dopamine and HVA suggest that LBV cases have a level of dopamine depletion similar to Parkinson's disease (PD). Additionally, ChAT activity in caudate and norepinephrine concentration in putamen were significantly reduced in the LBV group, which may have contributed to the absence of resting tremor and the milder presentation of parkinsonian features in this group compared with classic PD. In frontal, parietal, and temporal cortex, activity of ChAT in the LBV group was significantly reduced compared with controls and lower than in pure AD.
Langlais
P J
PJ
Department of Neurosciences, University of California at San Diego, School of Medicine.
Thal
L
L
Hansen
L
L
Galasko
D
D
Alford
M
M
Masliah
E
E
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis*; D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D001479:Basal Ganglia / Q000737:chemistry* / Q000201:enzymology; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000737:chemistry; D002540:Cerebral Cortex / Q000737:chemistry* / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis*; D006719:Homovanillic Acid / Q000032:analysis*; D006801:Humans; D016631:Lewy Bodies / Q000737:chemistry* / Q000201:enzymology; D010296:Parietal Lobe / Q000737:chemistry; D011699:Putamen / Q000737:chemistry; D012016:Reference Values; D012044:Regression Analysis; D013702:Temporal Lobe / Q000737:chemistry; D014443:Tyrosine / Q000032:analysis; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism
D015102:3,4-Dihydroxyphenylacetic Acid; D014443:Tyrosine; D014446:Tyrosine 3-Monooxygenase; D002795:Choline O-Acetyltransferase; D004298:Dopamine; D006719:Homovanillic Acid