title: [Acute myelitis after vaccination against hepatitis B].
abstract: A 56-year old man was hospitalized for spasmodic paraparesis with sphincter disorders. After exclusion of spinal cord compression and all other inflammatory, infectious or neoplastic causes, the possibility of a connexion with an hepatitis B vaccination performed with a recumbent vaccine three weeks before the neurological disorders appeared was considered. The pathogenesis of such a myelitis remains uncertain. It is based on the possible reactivation of a dormant virus or a crossed antigenic reaction between a protein of the vaccine and the nervous system. The course of the disease is usually favourable. The frequency of this complication would be more accurately determined if all neurological manifestations occurring after hepatitis B vaccination were reported.
authors.affiliation: Service de Clinique médicale, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Mahassin
authors.forename: J P
authors.initials: JP
authors.lastname: Algayres
authors.forename: J
authors.initials: J
authors.lastname: Valmary
authors.forename: H
authors.initials: H
authors.lastname: Bili
authors.forename: G
authors.initials: G
authors.lastname: Coutant
authors.forename: D
authors.initials: D
authors.lastname: Bequet
authors.forename: J P
authors.initials: JP
authors.lastname: Daly
mesh_terms: D000208:Acute Disease; D000212:Acyclovir / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000139:chemically induced; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009187:Myelitis / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D017325:Hepatitis B Vaccines; D000212:Acyclovir; D008775:Methylprednisolone
vernacular_title: Myélite aiguë après vaccination contre l'hépatite B.