Age-related proliferative activity in dermal melanocytic naevi detected by PCNA/cyclin expression.
A monoclonal antibody was used to demonstrate proliferating cell nuclear antigen in routine, formalin-fixed, paraffin-embedded tissue sections of dermal melanocytic naevi, including naevus naevocellularis partim lipomatodes, in different age-groups. The labelling indices of the melanocytic naevus cells were < 1% of those in the overlying epidermal basal cells, and showed a statistically significant decrease with ageing, and also in naevus naevocellularis partim lipomatodes, whereas the indices of the basal cells in the overlying interfollicular epidermis did not show any age-related changes.
Tu
P
P
Department of Dermatology, University of Ehime School of Medicine, Japan.
Miyauchi
S
S
Miki
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology / Q000473:pathology*; D000951:Antigens, Neoplasm / Q000032:analysis; D002452:Cell Count; D002455:Cell Division / Q000502:physiology; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000473:pathology; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D009508:Nevus, Pigmented / Q000276:immunology / Q000473:pathology*; D009687:Nuclear Proteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen