Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus.
By systematically dissecting the Rev proteins of feline immunodeficiency virus (FIV) and equine infectious anemia virus (EIAV), we have identified within each a short peptide that is functionally interchangeable with the effector domains found in Rev-like proteins from other retroviruses. The active sequences from FIV and EIAV differ in several respects from other known effectors and may represent a distinct class of effector domain.
Mancuso
V A
VA
Department of Pathology, University of California, San Francisco 94143-0506.
Hope
T J
TJ
Zhu
L
L
Derse
D
D
Phillips
T
T
Parslow
T G
TG
D000595:Amino Acid Sequence; D004252:DNA Mutational Analysis; D015694:Gene Products, rev / Q000235:genetics* / Q000494:pharmacology; D016089:Immunodeficiency Virus, Feline / Q000235:genetics*; D004860:Infectious Anemia Virus, Equine / Q000235:genetics*; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
D015694:Gene Products, rev; D011994:Recombinant Proteins