title: The ocular penetration of oral sparfloxacin in humans.
abstract: The penetration of sparfloxacin into the aqueous humor after oral administration was studied in 28 patients undergoing cataract surgery. Each patient received a single, oral dose of 400 mg of sparfloxacin. In eight other patients scheduled to undergo vitreal surgery, multiple daily oral doses were administered for a total amount of 1,000 mg. The aqueous levels were (mean +/- SEM) 0.127 +/- 0.036 microgram/ml to 0.404 +/- 0.159 microgram/ml from two to 24 hours after ingestion. In the vitreous, the mean drug level was 0.840 microgram/ml (range, 0.480 to 2.060 microgram/ml), from 4.3 to 8.0 hours after the most recent oral dose. Blood samples obtained at the same time as vitreous and aqueous taps were assayed by high-performance liquid chromatography. These data demonstrate that therapeutic levels of sparfloxacin may be achieved in noninflamed, noninfected eyes undergoing cataract or vitreous surgery.
authors.affiliation: Department of Ophthalmology, University Hospital, Dijon, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Bron
authors.forename: A P
authors.initials: AP
authors.lastname: Pechinot
authors.forename: C P
authors.initials: CP
authors.lastname: Garcher
authors.forename: G A
authors.initials: GA
authors.lastname: Guyonnet
authors.forename: A M
authors.initials: AM
authors.lastname: Kazmierczak
authors.forename: D A
authors.initials: DA
authors.lastname: Schott
authors.forename: H
authors.initials: H
authors.lastname: Lecoeur
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015363:Quinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C061363:sparfloxacin