Differential modulation of brain benzodiazepine receptor subtypes by ricinelaidic acid in vitro.
The C-18 hydroxy fatty acids ricinelaidic acid and ricinoleic acid diminish the oleic acid-stimulated agonist benzodiazepine binding in the rat brain in vitro. The oleic acid-induced enhancement of [3H]diazepam binding was completely abolished in membranes from the cerebellum, but only partially decreased in membranes from the hippocampus, cortex and the whole brain from 7-day-old rat pups. Related hydroxy fatty acids as well as hydroxy fatty acid esters had no effect on the oleic acid-stimulated diazepam receptor binding.
Witt
M R
MR
Research Institute of Biological Psychiatry, St Hans Hospital, Roskilde, Denmark.
Nielsen
M
M
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects*; D012277:Ricinoleic Acids / Q000494:pharmacology*
D009829:Oleic Acids; D011963:Receptors, GABA-A; D012277:Ricinoleic Acids; D019301:Oleic Acid; C030521:ricinoleic acid