Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis.
A 50-year-old woman allergic to penicillin with early latent syphilis was treated with two courses of doxycycline. Ten months after diagnosis, she had no evidence of serologic response. A lumbar puncture demonstrated asymptomatic neurosyphilis. Penicillin desensitization was performed and she was successfully treated. This case re-emphasizes the need for close serologic follow-up in patients with latent syphilis.
Zenilman
J M
JM
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Rand
S
S
Barditch
P
P
Rompalo
A M
AM
D003888:Desensitization, Immunologic; D004318:Doxycycline / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009494:Neurosyphilis / Q000175:diagnosis / Q000188:drug therapy*; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use*; D013129:Spinal Puncture; D013587:Syphilis / Q000188:drug therapy*; D013588:Syphilis Serodiagnosis; D017211:Treatment Failure
D010406:Penicillins; D004318:Doxycycline