Identification of complex t(15;17) in APL by FISH.
Fluorescence in situ hybridization (FISH) provides a sensitive and effective approach in identifying the RAR-alpha/PML fusion event in acute promyelocytic leukemia (APL) with the t(15;17). In the present study we describe the use of this assay for the identification of the RAR-alpha/PML fusion in bone marrow (BM) cells from three APL patients with complex t(15;17) translocations.
Chen
Z
Z
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona.
Morgan
R
R
Stone
J F
JF
Sandberg
A A
AA
D000293:Adolescent; D000328:Adult; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic