Partial deficiency of thyroxine-binding globulin: an HLA study.
Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothyroidism during 1988-1990. Analysis of the HLA system revealed the possibility that antigen DR6 may be considered as a risk factor for TBG deficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37.5%). Similar laboratory findings were also present in 16 mothers and 1 father.
Hníková
O
O
Clinic of Children and Adolescents, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
Ivasková
E
E
Kracmar
P
P
Kupková
L
L
Sajdlová
H
H
Zikmund
J
J
D003409:Congenital Hypothyroidism; D005260:Female; D015802:HLA-DR2 Antigen / Q000097:blood*; D015808:HLA-DR6 Antigen / Q000097:blood*; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D013975:Thyroxine-Binding Proteins / Q000032:analysis / Q000172:deficiency*
D015802:HLA-DR2 Antigen; D015808:HLA-DR6 Antigen; D013975:Thyroxine-Binding Proteins