title: [Liver cell necrosis during administration of clozapine].
abstract: A 38-year-old woman was treated for mutism with clozapine. After a week liver function disturbances developed, which disappeared when the treatment was discontinued. Histopathological investigation of a liver biopsy specimen revealed extensive liver cell necrosis. So far two patients have been described with cholestatic jaundice induced by clozapine, and one patient with toxic hepatitis due to clozapine.
authors.affiliation: Psychiatrisch Ziekenhuis H.C. Rümke groep, locatie Zeist.
authors.forename: J E
authors.initials: JE
authors.lastname: Hovens
authors.forename: L M
authors.initials: LM
authors.lastname: Vogtländer
authors.forename: H A
authors.initials: HA
authors.lastname: Verhoeve
authors.forename: P L
authors.initials: PL
authors.lastname: Thunnissen
mesh_terms: D000328:Adult; D003024:Clozapine / Q000506:poisoning* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008111:Liver Function Tests; D009155:Mutism / Q000188:drug therapy; D009336:Necrosis / Q000139:chemically induced
chemical_list: D003024:Clozapine
vernacular_title: Levercelnecrose tijdens gebruik van clozapine.