Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
We have previously demonstrated that an antibody to phosphoinositide-specific phospholipase C (PLC) isozyme, PLC-delta, intensely stained neurofibrillary tangles (NFT) in the brain tissue of Alzheimer's disease (AD). This study was performed to determine if abnormal PLC-delta accumulation might be present in the filamentous inclusions of other neurodegenerative diseases. We found that the anti-PLC-delta antibody stained neuronal inclusions of Pick's disease, progressive supranuclear palsy and diffuse Lewy body disease while the inclusions of idiopathic Parkinson's disease lacked PLC-delta accumulation. These results suggest a possible role for PLC-delta interaction in the formation of intraneuronal filamentous inclusions in human neurodegenerative diseases.
Shimohama
S
S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Perry
G
G
Richey
P
P
Takenawa
T
T
Whitehouse
P J
PJ
Miyoshi
K
K
Suenaga
T
T
Matsumoto
S
S
Nishimura
M
M
Kimura
J
J
D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology; D003704:Dementia / Q000201:enzymology / Q000473:pathology; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000201:enzymology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000201:enzymology* / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000201:enzymology / Q000473:pathology; D010300:Parkinson Disease / Q000201:enzymology / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000201:enzymology / Q000473:pathology; D010738:Type C Phospholipases / Q000378:metabolism*
D010738:Type C Phospholipases