[Effect of erythromycin on production of cytotoxin and attachment factors of bacteria].
We studied the effect of erythromycin (EM) on the attachment of Pseudomonas aeruginosa and Neisseria gonorrhoeae to HeLa and HT-177 cell and on cytotoxin production of P. aeruginosa. 1. EM inhibited attachment of these bacteria. 2. EM inhibited manifestation of the pili of these bacteria. 3. EM inhibited production of protein II, the second attachment factor of N. gonorrhoeae. 4. EM inhibited production of 66 K cytotoxin of P. aeruginosa. On the basis of these findings, it was suggested that EM might inhibit infection by repressing manifestation of the attachment factor and production of cytotoxin of the bacteria.
Mikasa
K
K
Second Department of Internal Medicine, Nara Medical University.
Kita
E
E
Sawaki
M
M
Konishi
M
M
Maeda
K
K
Hamada
K
K
Takeuchi
S
S
Sakamoto
M
M
Kunimatsu
M
M
Kashiba
S
S
D001422:Bacterial Adhesion / Q000187:drug effects*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D003603:Cytotoxins / Q000096:biosynthesis*; D004917:Erythromycin / Q000494:pharmacology*; D010861:Fimbriae, Bacterial / Q000187:drug effects; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism
D001426:Bacterial Proteins; D003603:Cytotoxins; D004917:Erythromycin