Protection by BTCP of cultured dopaminergic neurons exposed to neurotoxins.
This study presents 'in vitro' evidence for a protection of cultured dopaminergic neurons against the toxicity of 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenylpyridinium (MPP+) by pretreatment with BTCP, a selective and potent dopamine (DA) uptake blocker. Moreover, we show that, at low concentration (10 nM), treatment with MPP+, which is more selective than 6-OHDA for dopaminergic neurons, is followed by some regeneration of these neurons.
Cerruti
C
C
INSERM U336, USTL, Montpellier, France.
Drian
M J
MJ
Kamenka
J M
JM
Privat
A
A
D015655:1-Methyl-4-phenylpyridinium / Q000037:antagonists & inhibitors*; D000818:Animals; D002478:Cells, Cultured; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology*; D007091:Image Processing, Computer-Assisted; D009416:Nerve Regeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D016627:Oxidopamine / Q000037:antagonists & inhibitors*; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014741:Video Recording
D015259:Dopamine Agents; C056415:1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine; D016627:Oxidopamine; D010622:Phencyclidine; D015655:1-Methyl-4-phenylpyridinium; D004298:Dopamine