[Structural protein of hemorrhagic fever renal syndrome virus in uric fusion cells in hemorrhagic fever renal syndrome].
The efoliative cells in the urine of 21 hemorrhagic fever patients with renal syndrome (HFRS) were examined with Swiss blue staining. Fusion cells were found in the urine of 18 HFRS patients. The quantity of fusion cells was closely related to the severity of patients' condition and renal damage. Specific antigen of HFRS virus (HFRSV) was found immunohistochemically in all fusion cells. Specific monoclonal antibodies (McAb) of membrane protein and nucleocapsid protein from HFRSV were used for analyzing antigen in fusion cells. The positive rate of membrane protein antigen was 72.2%. Nucleocapsid protein was not found in all fusion cells. The above results suggested that the forming of fusion cells in the urine of HFRS patients is related membrane protein of HFRSV.
Dai
W
W
First Affiliated Hospital, Harbin Medical University.
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000652:urine*; D005260:Female; D006476:Orthohantavirus / Q000276:immunology / Q000302:isolation & purification*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000382:microbiology* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D015678:Viral Structural Proteins / Q000276:immunology / Q000652:urine*
D000956:Antigens, Viral; D015678:Viral Structural Proteins