title: A genetic linkage map of chromosome 21: a look at meiotic phenomena.
abstract: We have developed a genetic linkage map of chromosome 21 using 17 microsatellite marker polymorphisms. The markers span virtually the entire length of 21q, and define a sex-equal map of 56 cM. Extensive error checking has been used to provide an accurate map. All recombination events have been identified, allowing us to place within a small interval any new markers by genotyping only a few critical individuals. The resulting segregation data has been examined for several meiotic phenomena, including sex differences in recombination, age differences in recombination, interference, and segregation distortion.
authors.affiliation: Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129.
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: W
authors.initials: W
authors.lastname: Guillemette
authors.forename: D
authors.initials: D
authors.lastname: Rosen
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Donaldson
authors.forename: D
authors.initials: D
authors.lastname: Patterson
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D008540:Meiosis