title: [Disorders of coagulation/fibrinolysis and bleeding tendency].
abstract: The liver produces almost all the factors involved in coagulation and fibrinolysis. The hepatic reticuloendothelial system also plays an important role in disposing activated coagulation/fibrinolysis-related factors and inhibitors. In liver cirrhosis, the production of coagulation/fibrinolysis-related factors is diminished, as well as its inhibitors. Moreover, the hematological profile is complicated by a decreased rate of clearance, thrombocytopenia induced by hypersplenism, and some qualitative abnormalities of the coagulation factor. Hence, treatment for bleeding tendency observed in cirrhotic patients is diverse.
authors.affiliation: Central Clinical Laboratory, Yamanashi Medical College.
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: N
authors.initials: N
authors.lastname: Amemiya
authors.forename: S
authors.initials: S
authors.lastname: Kume
mesh_terms: D000990:Antithrombin III / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006474:Hemorrhagic Disorders / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications*; D010958:Plasminogen / Q000378:metabolism; D011486:Protein C / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D011486:Protein C; D000990:Antithrombin III; D005340:Fibrinogen; D010958:Plasminogen