GABAergic inputs modulate effects of interleukin-1 beta on supraoptic neurones in vitro.
We have previously reported that human recombinant interleukin (IL)-1 beta depolarizes membrane potentials in most rat hypothalamic supraoptic (SON) neurones in vitro. In the present study intracellular recordings have been made to examine contributions of local GABAergic interneurones to the effects of IL-1 beta on SON neurones in rat brain slice preparations. The results suggest that local GABAergic inputs modulate IL-induced excitatory responses, and are involved in tonic inhibition of SON neuronal activities.
Li
Z
Z
Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Inenaga
K
K
Yamashita
H
H
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002478:Cells, Cultured; D004357:Drug Synergism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007395:Interneurons / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D013495:Supraoptic Nucleus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D007375:Interleukin-1; D011994:Recombinant Proteins; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline