Interaction of metals in nickel-sensitive patients.
Nickel (Ni) dermatitis is thought to involve the formation of complexes between Ni ions and suitable proteins. 4 groups of 30 subjects who gave positive patch test responses to NiSO4 2.9% aq. were each retested to 1 of 4 different solutions containing equimolar (0.1 M) amounts of NiSO4 plus MgSO4, NiSO4 plus CuSO4, NiSO4 plus ZnSO4, and NiSO4 plus Li2SO4, respectively. The results, evaluated at 2 days by visual scoring only, demonstrated that the 4 metals exerted a different influence on the nickel reactions, perhaps interfering with one or more factors affecting the formation of Ni+ + complexes.
Santucci
B
B
Servizio di Allergologia, Istituto S. Gallicano, Rome, Italy.
Cannistraci
C
C
Cristaudo
A
A
Picardo
M
M
D003300:Copper / Q000009:adverse effects / Q000378:metabolism; D019327:Copper Sulfate; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000276:immunology* / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D017136:Ion Transport; D007509:Irritants / Q000009:adverse effects* / Q000378:metabolism; D018020:Lithium Compounds / Q000009:adverse effects / Q000378:metabolism; D008278:Magnesium Sulfate / Q000009:adverse effects / Q000378:metabolism; D009532:Nickel / Q000009:adverse effects* / Q000378:metabolism; D010328:Patch Tests; D013431:Sulfates / Q000009:adverse effects / Q000378:metabolism; D017967:Zinc Compounds / Q000009:adverse effects / Q000378:metabolism; D019287:Zinc Sulfate
D007509:Irritants; D018020:Lithium Compounds; D013431:Sulfates; D017967:Zinc Compounds; C029938:nickel sulfate; D008278:Magnesium Sulfate; D019287:Zinc Sulfate; D003300:Copper; D009532:Nickel; C054097:lithium sulfate; D019327:Copper Sulfate