[The effect of ultrasound, the polyene antibiotic amphotericin B and their combination on the biomembranes of yeast-like fungi in the genus Candida].
The effect of ultrasound (US) and the antibiotic amphotericin (A-B) on the structure of Candida albicans membranes. The most expression of destructive processes and appearance of free radicals in mycetic cells was observed in combination of US and A-B by chemiluminescence and ultrastructural analyses. The mechanisms of action of US and A-B on mycetic cells were discussed in the article. The expedience of the combination of US and A-B in candidiasis as a factor, increasing fungicidal effect on the candidiasis agent of Candida albicans.
Sergeev
P V
PV
Romanenko
I M
IM
Ukhina
T V
TV
Chukaev
S A
SA
D000666:Amphotericin B / Q000494:pharmacology*; D000704:Analysis of Variance; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008163:Luminescent Measurements; D008854:Microscopy, Electron; D014465:Ultrasonics
D000666:Amphotericin B
Vliianie ul'trazvuka, polienovogo antibiotika amfoteritsina B i ikh sochetaniia na biomembrany drozhzhepodobnykh grinov roda Candida.