Evaluation of the effect of formulation type of povidone/iodine preparations on infection and wound healing.
Different povidone/iodine (PI) dosage forms (e.g. solution, ointment, gel) in various PI concentrations and percentage of water were prepared. The efficacy of these formulations was assessed in vitro bacteriologically and clinically in large number of human and animal subjects. Comparison of their effect with those of other agents in some cases was made. The results obtained indicated that the antibacterial activity of PI in different formulation types was in the order: aqueous solution > water soluble ointment base containing 20% (w/w) water > aqueous gel base > water soluble ointment base containing 10% (w/w) water > water soluble ointment base > oleaginous base. PI is more efficient when comparing it with some conventional antiseptics, used clinically, and enhances wound healing process.
el-Sayed
A M
AM
Pharmaceutics Department, Faculty of Pharmacy, Assiut University, Egypt.
el-Khalek el-Timawy
A
A
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002162:Camelus; D002417:Cattle; D002418:Cattle Diseases; D004304:Dosage Forms; D005782:Gels; D006734:Horse Diseases; D006736:Horses; D006801:Humans; D008826:Microbial Sensitivity Tests; D009824:Ointments; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000662:veterinary*
D004304:Dosage Forms; D005782:Gels; D009824:Ointments; D011206:Povidone-Iodine