Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.
Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies in this series, feeding was chosen as the first route of administration. If the compound failed to induce mutations by this route, injection exposure was used. One gaseous chemical (1,3-butadiene) was tested only by inhalation. Those chemicals that were mutagenic in the sex-linked recessive lethal assay were further tested for the ability to induce reciprocal translocations. Eleven of the 50 chemicals tested were mutagenic in the SLRL assay. These included bis(2-chloroethyl) ether, 1,4-butanediol diglycidyl ether, 1-chloro-2-propanol, dimethyl methylphosphonate, dimethyl morpholinophosphoramidate, dimethyloldihydroxyethylene urea, 2,2-dimethyl vinyl chloride, hexamethylphosphoramide, isatin-5-sulfonic acid (Na salt), isopropyl glycidyl ether, and urethane. Five of these, including 1,4-butanediol diglycidyl ether, 2,2-dimethyl vinyl chloride, hexamethylphosphoramide, isopropyl glycidyl ether, and urethane, also induced reciprocal translocations.
Foureman
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Department of Zoology, University of Wisconsin, Madison.
Mason
J M
JM
Valencia
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R
Zimmering
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D000818:Animals; D002072:Butylene Glycols / Q000633:toxicity; D002728:Chlorohydrins / Q000633:toxicity; D016208:Databases, Factual; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D004852:Epoxy Compounds / Q000633:toxicity; D004986:Ether / Q000031:analogs & derivatives / Q000633:toxicity; D005804:Genes, Lethal; D008040:Genetic Linkage; D018095:Germ-Line Mutation; D006492:Hempa / Q000633:toxicity; D007093:Imidazoles / Q000633:toxicity; D007510:Isatin / Q000031:analogs & derivatives / Q000633:toxicity; D008297:Male; D015394:Molecular Structure; D009025:Morpholines / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry* / Q000145:classification / Q000633:toxicity*; D009316:National Institutes of Health (U.S.); D009943:Organophosphorus Compounds / Q000633:toxicity; D014178:Translocation, Genetic; D014481:United States; D014520:Urethane / Q000633:toxicity; D014752:Vinyl Chloride / Q000031:analogs & derivatives / Q000633:toxicity; D014960:X Chromosome / Q000187:drug effects*
D002072:Butylene Glycols; D002728:Chlorohydrins; D004852:Epoxy Compounds; D007093:Imidazoles; D009025:Morpholines; D009153:Mutagens; D009943:Organophosphorus Compounds; D004986:Ether; C043628:dimethylol dihydroxyethyleneurea; C031116:dimethyl methylphosphonate; D014520:Urethane; C086173:isopropyl glycidyl ether; C051950:1-chloro-2-methylpropene; C101013:dimethyl morpholinophosphoramidate; C006767:bis(2-chloroethyl)ether; C086177:isatin-5-sulfonic acid; D007510:Isatin; C014376:1,4-bis(2,3-epoxypropoxy)butane; D006492:Hempa; D014752:Vinyl Chloride; C015750:1-chloro-2-propanol