[Liver cell necrosis during administration of clozapine].
A 38-year-old woman was treated for mutism with clozapine. After a week liver function disturbances developed, which disappeared when the treatment was discontinued. Histopathological investigation of a liver biopsy specimen revealed extensive liver cell necrosis. So far two patients have been described with cholestatic jaundice induced by clozapine, and one patient with toxic hepatitis due to clozapine.
Hovens
J E
JE
Psychiatrisch Ziekenhuis H.C. Rümke groep, locatie Zeist.
Vogtländer
L M
LM
Verhoeve
H A
HA
Thunnissen
P L
PL
D000328:Adult; D003024:Clozapine / Q000506:poisoning* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008111:Liver Function Tests; D009155:Mutism / Q000188:drug therapy; D009336:Necrosis / Q000139:chemically induced
D003024:Clozapine
Levercelnecrose tijdens gebruik van clozapine.