Pharmacokinetics of ciclopirox olamine after vaginal application to rabbits and patients.
The authors reported the plasma levels and pharmacokinetic parameters of ciclopirox olamine in rabbits after i.v. and intravaginal administrations and in female patients after vaginal administration. Plasma levels of total and free ciclopirox were determined by a HPLC method. In rabbit ciclopirox showed a half-life of 2.22 h and an intravaginal bioavailability of about 2%. In female patients ciclopirox showed low intravaginal absorption; this value might explain the good local and systemic tolerability and also the penetration of drug in deep tissue.
Coppi
G
G
Pharmacological and Toxicological Department, Poli Industria Chimica, Rozzano, Milan, Italy.
Silingardi
S
S
Girardello
R
R
De Aloysio
D
D
Manzardo
S
S
D000282:Administration, Intravaginal; D000328:Adult; D000818:Animals; D000077768:Ciclopirox; D005260:Female; D006207:Half-Life; D006801:Humans; D011728:Pyridones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits
D011728:Pyridones; D000077768:Ciclopirox