Establishment and characteristics of two new human mammary carcinoma lines serially transplantable in nude mice.
Two human mammary carcinomas of postmenopausal women were successfully transplanted into nude mice. Both tumours were classified as epidermal-growth-factor-, oestradiol- and progesterone-receptor-negative and c-erbB2-protein-positive. Histological studies of the primary tumours (4000 and 4151) revealed ductal invasive mammary carcinomas. In the first passages the precondition for the growth of breast carcinoma 4000 were pretreatments of the nude mice with oestradiol and peanut oil before transplantation. The mammary carcinomas 4000 and 4151 described here are suitable for in vivo testing of antineoplastic substances and for biological studies.
Naundorf
H
H
Max Delbrück Centre (MDC) for Molecular Medicine, Berlin-Buch, Germany.
Fichtner
I
I
Saul
G J
GJ
Haensch
W
W
Büttner
B
B
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D009856:Oncogene Proteins, Viral / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000737:chemistry / Q000187:drug effects / Q000637:transplantation*
D000970:Antineoplastic Agents; D066246:ErbB Receptors; D009856:Oncogene Proteins, Viral; D018719:Erb-b2 Receptor Tyrosine Kinases; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone