Side effects of long acting cholinesterase inhibitors.
This paper reviews the side effects of the two long acting cholinesterase inhibitors tacrine and velnacrine. It will focus on tacrine which has been most studied. The two drugs are special as the dosage of them is guided mainly by side effects and not by therapeutic effects in contrast to most drugs used for psychiatric disorders.
Beermann
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B
Medical Products Agency, Uppsala, Sweden.
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D013619:Tacrine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000637:Transaminases / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D013619:Tacrine; D000637:Transaminases; C056424:velnacrine