title: Post-mortem limitations of body composition analysis by computed tomography.
abstract: Few of the indirect methods for measuring body composition have every been validated against direct human cadaver evidence. Computed tomography (CT), like NMR, has proved to be an important diagnostic tool and they appear to be the techniques of the future for body composition studies. The purpose of the present study (Cadaver Analysis Study III), undertaken at the Vrije Universiteit Brussel in a joint venture with the University of Göteborg, Sweden, was to validate tomographic measurements of volumes and areas from different tissues using data from CT-scanning of unembalmed deep-frozen cadavers and data collected by dissection of the same cadavers. Six Belgian adults were extensively measured and dissected. The body was divided into several slices for comparison of the CT image with photography of the same slice and comparison of tissue-volumes per segment for the whole body. Due to post-mortem changes and the frozen state of the cadavers, the CT measurements were greatly affected by artefacts disturbing adipose tissue (AT) and muscle area determinations. Only the bone area measurements were similar between the two techniques. However, when the volumes (per segment) of the same tissues were considered, no apparent difference was found between CT and dissection data for the muscle volume.
authors.affiliation: Department of Diagnostic Radiology, University of Göteborg.
authors.forename: V
authors.initials: V
authors.lastname: Janssens
authors.forename: P
authors.initials: P
authors.lastname: Thys
authors.forename: J P
authors.initials: JP
authors.lastname: Clarys
authors.forename: H
authors.initials: H
authors.lastname: Kvis
authors.forename: B
authors.initials: B
authors.lastname: Chowdhury
authors.forename: E
authors.initials: E
authors.lastname: Zinzen
authors.forename: J
authors.initials: J
authors.lastname: Cabri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology*; D015925:Cryopreservation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D012016:Reference Values; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed