Effects of nonsteroidal antiinflammatory drugs on bone loss in chronic inflammatory disease.
Several controlled clinical trials have indicated that nonsteroidal antiinflammatory drugs may slow alveolar bone loss in periodontitis. Demonstration of this efficacy is dependent on the development of accurate, sensitive, and specific quantitative methods for the assessment of bony change, such as digital subtraction radiography. Further studies of such methodologies are required to more fully investigate the effect of nonsteroidal antiinflammatory drugs in rheumatoid arthritis.
Jeffcoat
M K
MK
University of Alabama School of Dentistry, Birmingham 35294-0007.
Reddy
M S
MS
Moreland
L W
LW
Koopman
W J
WJ
D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001862:Bone Resorption / Q000517:prevention & control*; D002908:Chronic Disease; D006801:Humans; D011859:Radiography; D013382:Subtraction Technique
D000894:Anti-Inflammatory Agents, Non-Steroidal