Ligand binding model for G-protein-linked receptors: an update.
A ligand binding model for receptors linked to G-protein activation proposes that antagonists and agonists are able to distinguish two different binding sites on the receptor.
Saunders
J
J
Medicinal Chemistry II, Glaxo Group Research, Greenford, Middlesex, UK.
D000318:Adrenergic beta-Agonists / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D001665:Binding Sites; D019204:GTP-Binding Proteins / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D008956:Models, Chemical; D018727:Muscarinic Antagonists; D017433:Protein Structure, Secondary; D011943:Receptors, Adrenergic, beta / Q000378:metabolism* / Q000502:physiology; D011976:Receptors, Muscarinic / Q000378:metabolism* / Q000502:physiology
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D008024:Ligands; D018727:Muscarinic Antagonists; D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D019204:GTP-Binding Proteins