Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.
In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematologic and pneumologic toxicity is discussed.
Bolla
G
G
Service de Medecine Interne, Centre Hospitalo-Universitaire de la Timone, Marseille, France.
Disdier
P
P
Harle
J R
JR
Verrot
D
D
Weiller
P J
PJ
D000208:Acute Disease; D000749:Anemia, Megaloblastic / Q000139:chemically induced* / Q000188:drug therapy; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*
D011239:Prednisolone; D002955:Leucovorin; D008727:Methotrexate