title: Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP.
abstract: Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins.
authors.affiliation: Department of Cellular and Molecular Biology, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Moritoyo
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: B I
authors.initials: BI
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Fujisawa
authors.forename: M
authors.initials: M
authors.lastname: Osame
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology*
chemical_list: D004279:DNA, Viral; D015335:Molecular Probes