title: [Role of phenotype in liver function in adolescents with change of the tuberculin reaction during chemoprophylaxis].
abstract: A total of 92 adolescents aged 13-17 with a turn in the tuberculin reactions underwent clinicomorphological and laboratory examinations at sanatorium where they received chemoprophylaxis for tuberculosis. The clinicomorphological examination involved description of phenotypical characteristics of dysembryogenetic stigmas by 22 anatomical units. Hepatic function was assessed before and during chemoprophylaxis by serum biochemistry: total and direct bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, cholesterol, triglycerides, urea, uric acid. High stigmatization of the phenotype, the presence of dysembryogenetic stigmas of the face and skull, nose, jaws, chest, abdomen and pelvis occurred more frequently in adolescents with changes in serum biochemistry reflecting hepatic condition.
authors.forename: I A
authors.initials: IA
authors.lastname: Sirenko
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Grechanina
authors.forename: L S
authors.initials: LS
authors.lastname: Ozerova
mesh_terms: D000293:Adolescent; D001823:Body Composition; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests; D010641:Phenotype; D014374:Tuberculin Test; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control
chemical_list: D007538:Isoniazid
vernacular_title: Znachenie fenotipa dlia funktsionalńogo sostoianiia pecheni u podrostkov s virazhom tuberkulinovykh reaktsiĭ pri provedenii khimioprofilaktiki.