title: A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
abstract: The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-type tetracycline resistance genes from members of the family Enterobacteriaceae. The new determinant has been assigned to class H.
authors.affiliation: Department of Veterinary Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: L M
authors.initials: LM
authors.lastname: Hansen
authors.forename: L M
authors.initials: LM
authors.lastname: McMurry
authors.forename: S B
authors.initials: SB
authors.lastname: Levy
authors.forename: D C
authors.initials: DC
authors.lastname: Hirsh
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016979:Pasteurella multocida / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D013752:Tetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013753:Tetracycline Resistance / Q000235:genetics* / Q000502:physiology; D014422:Turkeys
chemical_list: D004247:DNA; D013752:Tetracycline