title: Serum bactericidal activity after administration of four cephalosporins in healthy volunteers.
abstract: Serum bactericidal activity (SBA) was determined against ten strains each of Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris and Enterobacter cloacae in six volunteers 1 h and 4 h after intravenous infusion of 1 g and 2 g cefotaxime and cefmenoxime, and 2 g flomoxef, and against ten strains of Pseudomonas aeruginosa after infusion of 1 g and 2 g ceftazidime. Flomoxef showed the highest SBA against methicillin-susceptible Staphylococcus aureus. All cephalosporins had high SBA against gram-negative rods. Cefotaxime had the highest SBA against Klebsiella pneumoniae and Enterobacter cloacae. The SBA against Pseudomonas aeruginosa after 1 g and 2 g doses of ceftazidime was very similar.
authors.affiliation: Department of Environmental Medicine, University Hospital, Freiburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Lemmen
authors.forename: A
authors.initials: A
authors.lastname: Kropec
authors.forename: I
authors.initials: I
authors.lastname: Engels
authors.forename: A
authors.initials: A
authors.lastname: Busse
authors.forename: F D
authors.initials: FD
authors.lastname: Daschner
mesh_terms: D000328:Adult; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008297:Male; D015610:Serum Bactericidal Test; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D002511:Cephalosporins