Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures.
OBJECTIVE
To determine whether the use of opioids could reduce the hypoxemia and hemodynamic instability associated with routine intensive care procedures in neonates with respiratory distress.


METHODS
Randomized and placebo-controlled study.


METHODS
Physiological, plasma beta-endorphin, cortisol, and glucose responses to routine treatment procedures were studied in 84 mechanically ventilated distressed neonates randomized into groups receiving 1 mg/kg meperidine or 0.9% saline 15 minutes before tracheal suction or routine nursing care.


RESULTS
The duration of hypoxemia (transcutaneous partial pressure of O2 < 6.6 kPa (< 50 mm Hg) and/or arterial blood oxygen saturation < 80%) during treatment procedures was significantly longer in the saline group (mean 82 vs 36 seconds, P = .001) and distress quantified by a novel behavioral scoring method was much higher. Changes in arterial blood pressure, heart rate, or plasma beta-endorphin, cortisol, and glucose concentration did not show any statistically significant differences between the groups.


CONCLUSIONS
Newborns with respiratory difficulties often suffer from hypoxemia during essential treatment procedures. The use of opioid analgesia may reduce the duration of hypoxemia and the associated distress and, therefore, may improve the long-term results of neonatal intensive care.
Pokela
M L
ML
Department of Paediatrics, University of Oulu, Finland.
D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D000860:Hypoxia / Q000517:prevention & control*; D007224:Infant Care; D007231:Infant, Newborn; D008614:Meperidine / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000628:therapy; D013312:Stress, Physiological / Q000209:etiology / Q000517:prevention & control; D013396:Suction / Q000009:adverse effects; D001615:beta-Endorphin / Q000097:blood
D001615:beta-Endorphin; D008614:Meperidine; D010100:Oxygen; D006854:Hydrocortisone