title: Metabolism of 5 beta-cholestane-3 alpha,7 alpha-diol in ileectomized rats.
abstract: The effect of ileectomy on the composition of biliary bile acids and the metabolism of 5 beta-cholestane-3 alpha,7 alpha-diol was studied in rats. In the ileectomized rats, there was an increase in the percentage of cholic acid group (cholic acid and deoxycholic acid) as compared with the normal rats. After rats with a bile fistula were given intravenously 5 beta-[7 beta-3H] cholestane-3 alpha,7 alpha-diol, there was a 3-fold increase in the percentage of [3H]cholic acid in the ileectomized rats compared to the normal rats. The findings have suggested that an increase in the percentage of cholic acid group in the ileectomized rats is due to the increased formation of cholic acid through an alternative pathway which involves 5 beta-cholestane-3 alpha,7 alpha-diol.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Tottori University, Yonago.
authors.forename: Y
authors.initials: Y
authors.lastname: Ogura
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakabou
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001835:Body Weight; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002777:Cholestanols / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism* / Q000601:surgery; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001647:Bile Acids and Salts; D002777:Cholestanols; D002635:Chenodeoxycholic Acid; C007426:dihydroxycoprostane