New polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) not linked to schizophrenia in five Canadian pedigrees.
A new HincII polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) is reported. In light of evidence indicating possible dysfunction of the 5-HT neurotransmitter system in schizophrenia, this new 5-HT receptor polymorphism was tested for linkage to schizophrenia in 5 Canadian pedigrees. Although 1 of the 5 pedigrees tested had a slightly positive lod score, there was no evidence overall for linkage to schizophrenia under dominant, recessive, or two locus models.
Sidenberg
D G
DG
Section of Neurogenetics, Laboratories of the Clarke Institute of Psychiatry, Toronto, Ont., Canada.
Bassett
A S
AS
Demchyshyn
L
L
Niznik
H B
HB
Macciardi
F
F
Kamble
A B
AB
Honer
W G
WG
Kennedy
J L
JL
D002170:Canada; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D011985:Receptors, Serotonin