The influence of monophosphoryl lipid A (MPL) on erythrocyte autoantibody formation.
The onset and the amount of erythrocyte autoantibodies induced by the injection of C57BL/6N mice with rat red blood cells (RRBC) were hastened and increased, respectively, after the administration of monophosphoryl lipid A (MPL); this was not the case for similarly treated BALB/cAnN mice, which make a lower autoantibody response after immunization with RRBC. The transfer of spleen cells from donor C57BL/6N mice immunized with RRBC suppressed autoantibody formation in recipient mice subsequently immunized with RRBC; however, treatment with MPL prevented neither the induction nor the expression of such suppression. This suggests that the increased autoantibody response in RRBC-immunized C57BL/6N mice treated with MPL is not due to the inactivation of suppressor cell activity which, in other studies, was found to be extremely sensitive to MPL.
Hraba
T
T
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook-II Research Facility, Rockville, MD.
Baker
P J
PJ
Taylor
C E
CE
Fauntleroy
M B
MB
Stashak
P W
PW
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D003298:Coombs Test; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D008050:Lipid A / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D051381:Rats / Q000276:immunology; D013154:Spleen / Q000166:cytology
D001323:Autoantibodies; D008050:Lipid A; C048436:monophosphoryl lipid A