[The treatment of histiocytosis X (Langerhans-cell histiocytosis) with alpha-interferon preparations].
Langerhans cell histiocytosis (LCH) and histiocytosis class II (without Langerhans cells) were treated in 10 and 2 patients, respectively, with alpha-interferon preparations: recombinant alpha 2-interferon and two combined preparations containing natural alpha-interferon and immune response phase 1 cytokines. The patients' age ranged from 18 to 61 years, all of them had multiple lesions. Six of them exhibited dysfunctions of the affected organs. As shown by the results of 16-52-month follow-up, LCH patients' disease persisted in chronic active stage without progression (8 cases) or reached a complete remission (1 case), one patient died. In histiocytosis class II alpha-interferon administration was uneffective.
Lukina
E A
EA
Kuznetsov
V P
VP
Beliaev
D L
DL
Kaplanskaia
I B
IB
Mokeeva
R A
RA
D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D013997:Time Factors
D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; C085827:cytoferon; C062252:leukinferon
Lechenie gistiotsitoza-X (gistiotsitoz iz kletok Langergansa) preparatami al'fa-interferona.