Effects of glucagon-like peptide-1(7-36)amide on the concentrations of insulin and glucose in sheep.
1. The effects of glucagon-like peptide-1(7-36)amide (GLP-1) and/or glucose on the concentration of insulin in fed and starved sheep were studied. Insulin concentrations in starved sheep increased with increasing doses of GLP-1 (0.23-2.27 nmol) when given together with glucose. 2. Hyperglycaemia was necessary for GLP-1 to stimulate increases in serum insulin but the level required was low (0.4 mmol/l or less). 3. In fed sheep hyperglycaemia alone caused an increase in serum insulin. 4. GLP-1 improved the ability of both fed and starved sheep to remove exogenous glucose from the circulation. 5. GLP-1 did not augment insulin secretion in response to other known insulin secretagogues.
Martin
P A
PA
Hannah Research Institute, Ayr, U.K.
Faulkner
A
A
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D007328:Insulin / Q000097:blood*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D012756:Sheep
D001786:Blood Glucose; D007328:Insulin; D010455:Peptides; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; C055454:glucagon-like peptide 1 (1-36)amide