[The effects of various doses of lipopolysaccharide on endotoxin-induced uveitis in rats].
We induced intraocular inflammation by foot pad injection of lipopolysaccharide (LPS) in rats to investigate the inflammatory effects of the various doses of the LPS and the anti-inflammatory effects of prostaglandin (PG) synthetase inhibitor. The aqueous protein concentration curve showed two peaks, an early one at 3 hours and another at 24 hours after the injection, at doses higher than 12.5 micrograms per rat. The PG synthetase inhibitor reduced the aqueous protein concentration by 30 to 60% at both of the two peaks. These results suggest the involvement of PG in the mechanism of the endotoxin-induced uveitis.
Ishiguro
M
M
Department of Ophthalmology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Katayama
T
T
Tachinami
K
K
Hiraki
S
S
Kubota
Y
Y
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014605:Uveitis / Q000139:chemically induced*
D016861:Cyclooxygenase Inhibitors; D008070:Lipopolysaccharides; D011453:Prostaglandins