[Anti-free radical damage of chronic glomerulonephritis with febrifugal and diuretic medicinal herbs].
A clinical trial to evaluate the method of removing Heat and eliminating Dampness (RHED) with febrifugal and diuretic medicinal herbs in treating chronic glomerulonephritis (CGN) patients was conducted. 45 cases of CGN were compared with 42 cases of healthy persons as control. The results showed that CGN patient's serum levels of lipid peroxide (LPO) increased, superoxide dismutase (SOD) and trace elements such as Zn, Cu, Se dropped down. After treatment with RHED the activity of LPO, SOD, catalase (CAT) revealed significant improvement. Serum levels of Zn, Cu, Se increased. It was considered that free radical damage was a general mechanisms of CGN and anti-free radical damage with RHED might play an important role in treatment.
Yu
E K
EK
Heilongjiang Institute of TCM, Harbin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002374:Catalase / Q000097:blood*; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*; D014131:Trace Elements / Q000097:blood
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D014131:Trace Elements; D002374:Catalase; D013482:Superoxide Dismutase