[Effect of polychlorinated biphenyls on the activity of antioxidant enzymes and lipid peroxidation in muscles and liver of two species of black sea fish].
The effect of polychlorinated biphenyls (PCB) on the state of the antioxidant system and lipid peroxidation in the liver and muscles of two Black Sea fish species-Mullus barbatus and Scorpaena porcus-has been studied. It was found that in the muscles PCB were accumulated in lesser amounts than in the liver. In the liver the activity of antioxidant enzymes did not differ significantly in the fishes kept in sea water, aquarium or aquarium plus PCB, whereas in the muscles there was an increase in the lipoxygenase activity and a decrease in the peroxidase activity. The levels of antioxidants (glutathione, carotenoids, vitamins A, E and K) and the lipid component ratio did not change considerably in control and experimental fishes. In the muscles and livers of fishes exposed to PCB there was a tendency of triene conjugate and lipid hydroperoxide content to increase. There was an increase in the correlations in the sequence: sea water-->aquarium-->aquarium plus PCB between all the parameters under study in the muscles and livers which is suggestive of mobilization of molecular protective mechanisms in response to detrimental factors.
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D000818:Animals; D005260:Female; D005399:Fishes; D015227:Lipid Peroxidation / Q000187:drug effects*; D008084:Lipoxygenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls; D010105:Oxygenases; D008084:Lipoxygenase
Deĭstvie polikhlorirovannykh bifenilov na aktivnost' antioksidantnykh fermentov i perekisnoe okislenie lipidov v myshtsakh i pecheni dvukh vidov chernomorskikh ryb.