[Human echinococcosis: the role of histocompatibility antigens in realizing infestations and the characteristics of their course].
The role of histocompatibility antigens in the realization of invasions and the nature of its course were studied in 71 patients with Echinococcus granulosus infection and in 18 with E. multilocularis infection. It has been shown that the effects of HLA antigens on the realization of invasion is heterodirectional; the factors predisposing to the occurrence of echinococcosis are HLA-B5, B18, and A28 antigens, whereas those preventing their realization are HLA-B14 antigen. The carriage of HLA-B5 and B18 antigens determines a high risk of E. granulosus infection of the lungs and liver. The realization of the latter is prevented by the carriage of HLA-B27 antigen. The development of E. multilocularis infection of the liver is promoted by that of HLA-A11, whereas the carriage of HLA-A9 antigen prevents the occurrence of this lesion. Solitary hepatic lesion in E. granulosus infection correlates with HLA-A10 and B18 antigens, while multiple lesion with HLA-B5 antigen, but the development of E. multilocularis infection metastases is associated with HLA-B8 antigen. The occurrence of spontaneous cystic ruptures of E. granulosus correlates with HLA-A32, A26, and B5 antigens, which is likely to associated with cystic formation defect due to the influence of these factors.
Shcherbakov
A M
AM
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002353:Carrier State / Q000276:immunology; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D004198:Disease Susceptibility; D004443:Echinococcosis / Q000209:etiology / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009031:Moscow
D006680:HLA Antigens
Ekhinokokkozy cheloveka: rol' antigenov gistosovmestimosti v realizatsii invaziĭ i osobennostiakh ikh techeniia.