title: Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil.
abstract: Four aryl vinyl diethyl benzylphosphonates related to Fostedil were synthesized and evaluated for their in vitro calcium-inhibitory activity. None of these compounds exhibited any calcium antagonistic profile. Unlike a series of diethyl-styryl benzylphosphonates, previously described, the presence of two aromatic rings linked by a vinyl group did not improve the calcium antagonistic activity.
authors.affiliation: Laboratoires Pierre Fabre, Castres, France.
authors.forename: G
authors.initials: G
authors.lastname: Tchani
authors.forename: G
authors.initials: G
authors.lastname: Baziard-Mouysset
authors.forename: J L
authors.initials: JL
authors.lastname: Stigliani
authors.forename: M
authors.initials: M
authors.lastname: Payard
authors.forename: R
authors.initials: R
authors.lastname: Bonnafous
authors.forename: J
authors.initials: J
authors.lastname: Tisne-Versailles
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D052160:Benzothiazoles; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D013844:Thiazoles / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
chemical_list: D052160:Benzothiazoles; D002121:Calcium Channel Blockers; D013844:Thiazoles; D014753:Vinyl Compounds; C035950:fosfedil