Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil.
Four aryl vinyl diethyl benzylphosphonates related to Fostedil were synthesized and evaluated for their in vitro calcium-inhibitory activity. None of these compounds exhibited any calcium antagonistic profile. Unlike a series of diethyl-styryl benzylphosphonates, previously described, the presence of two aromatic rings linked by a vinyl group did not improve the calcium antagonistic activity.
Tchani
G
G
Laboratoires Pierre Fabre, Castres, France.
Baziard-Mouysset
G
G
Stigliani
J L
JL
Payard
M
M
Bonnafous
R
R
Tisne-Versailles
J
J
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D052160:Benzothiazoles; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D013844:Thiazoles / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D052160:Benzothiazoles; D002121:Calcium Channel Blockers; D013844:Thiazoles; D014753:Vinyl Compounds; C035950:fosfedil