Protein kinase C activity in the rat ovary: increasing enzyme activity and presence of an endogenous inhibitor during pregnancy.
1. Protein kinase C (PKC) activity was measured in corpora lutea and ovarian interstitial tissues obtained from rats on days 7, 13/14 and 20 of normal pregnancy. 2. PKC activity increased steadily from day 7 to day 20 of pregnancy in luteal tissue but not in ovarian interstitial tissues. 3. Cytosolic fractions of both tissue types inhibited PKC activity in a control preparation of the enzyme, suggesting that both tissues contain an endogenous inhibitor of PKC throughout pregnancy.
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Department of Physiology and Pharmacology, University of South Dakota, School of Medicine, Vermillion 57069-9986.
D000818:Animals; D003338:Corpus Luteum / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D005260:Female; D010053:Ovary / Q000201:enzymology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011493:Protein Kinase C