Comparison of the pathogenicity of rinderpest virus in different strains of rabbits.
Pathogenicity of the lapinized Nakamura-III (L) strain of rinderpest virus (RPV) was examined in four strains of rabbits consisting of two inbred strains (NW-NIBS and DUY-NIBS) and two outbred strains maintained in closed colony (NW-NIBS and JW-NIBS) using a marmoset lymphoblastoid cell line, B95a cell-passaged virus and tissue homogenates of virus-infected rabbits. The cell culture virus was found to maintain virulence for rabbits of both closed colony and inbred NW-NIBS strain similar to the homogenate virus. Among the strains investigated, inbred NW-NIBS strain showed the highest susceptibility to RPV. Thus experimental model in an inbred rabbit using cell culture virus became useful.
Okita
M
M
Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Japan.
Ochikubo
F
F
Kamata
Y
Y
Kamata
H
H
Yamanouchi
K
K
Kai
C
C
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001065:Appendix / Q000382:microbiology / Q000473:pathology; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D002144:Callithrix; D002460:Cell Line; D004064:Digestive System / Q000382:microbiology / Q000473:pathology; D004198:Disease Susceptibility; D007150:Immunohistochemistry; D011817:Rabbits; D012301:Rinderpest / Q000382:microbiology* / Q000473:pathology; D012302:Rinderpest virus / Q000472:pathogenicity*; D013045:Species Specificity; D014774:Virulence
D000956:Antigens, Viral