Long-term survival after allogeneic bone marrow transplantation complicated by trichosporosis.
We report a case of sepsis due to Trichosporon cutaneum in a 20-year-old patient with acute promyelocytic leukemia. Neutropenia with a hypocellular marrow persisted for 90 days after two courses of induction chemotherapy with mitoxantrone and ara-C. Amphotericin B, fluconazole, and granulocyte-macrophage colony-stimulating factors were administered. Neutropenia (ANC < 1,000/microL) resolved 14 days after HLA-identical bone marrow transplantation. The patient is in remission, with a performance status of 100%, more than 1 year after transplantation.
Naum
S
S
West Penn Hospital, Western Pennsylvania Cancer Institute, Pittsburgh 15224.
Petursson
S R
SR
Weinbaum
D
D
Rosenfeld
C S
CS
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000401:mortality / Q000628:therapy*; D008297:Male; D009181:Mycoses / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D009503:Neutropenia / Q000503:physiopathology; D017741:Survivors; D014250:Trichosporon
D000935:Antifungal Agents; D000970:Antineoplastic Agents