Richter's syndrome associated with loss of response to transforming growth factor-beta.
A patient with chronic lymphocytic leukemia developed a large cell lymphoma apparently derived from the same neoplastic B-cell clone (Richter's syndrome). At the same time, mitogen-stimulated proliferation of the patient's circulating leukemic B-cells was no longer inhibited by the regulatory cytokine transforming growth factor-beta (TGF-beta), suggesting that such loss of inhibition might be contributing to the clinical and biological progression of the disease.
Nowell
P C
PC
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.
Moore
J S
JS
Fox
F E
FE
Capocasale
R J
RJ
Kant
J A
JA
Besa
E C
EC
D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology*; D002455:Cell Division; D003864:Depression, Chemical; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D013577:Syndrome; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000473:pathology
D016212:Transforming Growth Factor beta