[The possible neurochemical mechanisms of the neuroleptic action of buspirone-like serotonin agonists].
The experiments on animals (rats and mice) and pigeons have established that buspirone and other serotonin agonists such as 1-(2-pyrimidinyl)-piperazine derivatives such as ipsapirone (TVX Q 7821), levopirone, kampirone, and sepirone have some pharmacological properties which are typical of neuroleptics. The serotonin agonists under study accelerate rat brain dopamine metabolism show their antagonism with apomorphine in the stereotypy and climbing tests in mice, suppress the conditioned avoidance reflex in rats, and eliminate apomorphine-induced vomiting in pigeons. Serotonin agonists, like serotonin, have been shown to stimulate the impulse-dependent release of 3H-dopamine from the slices of the rat nucleus accumbens and striatum. The capacity of buspirone and other serotonin antagonists of modulating dopamine release is not eliminated by 1A/B and 2 serotonin antagonists such as propranolol (3 microM) and metesergide (1 microM), but it is inhibited by ICS 205-930, a selective antagonist of 3HT receptors.
Kharin
N A
NA
Dolzhenko
A T
AT
Titievskiĭ
A V
AV
Naletov
S V
SV
D000374:Aggression / Q000187:drug effects; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002065:Buspirone / Q000494:pharmacology*; D010856:Columbidae; D003214:Conditioning, Classical / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D051381:Rats; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D014150:Antipsychotic Agents; D017366:Serotonin Receptor Agonists; D001058:Apomorphine; D002065:Buspirone; D004298:Dopamine
Vozmozhnye neĭrokhimicheskie mekhanizmy neĭrolepticheskogo deĭstviia buspironopodobnykh agonistov serotonina.