title: [The pharmacokinetics of propranolol when used with the propercuten transdermal therapeutic system (experimental data)].
abstract: The pharmacokinetic studies of propranolol following the application of the propercuten transdermal therapeutic system were performed in conscious rabbits previously assigned to 3 groups. Different forms of propercuten (forte and mite) were used in different groups, different areas of its application being employed. Pulsed intravenous injections of propranolol were given to Group 1 rabbits to conduct another series of pharmacokinetic studies. The rate of drug administration to the systemic bed was 0.08 mg/h per cm propercuten. The constant injection rate was maintained during 5 days, but when propercuten was withdrawn the elimination time of propranolol was 24 hours.
authors.forename: V K
authors.initials: VK
authors.lastname: Piotrovskiĭ
authors.forename: V G
authors.initials: VG
authors.lastname: Belolipetskaia
authors.forename: A E
authors.initials: AE
authors.lastname: Vasil'ev
authors.forename: V A
authors.initials: VA
authors.lastname: Shorr
authors.forename: O N
authors.initials: ON
authors.lastname: Chichenkov
authors.forename: M M
authors.initials: MM
authors.lastname: Fel'dshteĭn
authors.forename: V I
authors.initials: VI
authors.lastname: Metelitsa
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001702:Biopharmaceutics; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D011433:Propranolol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D013997:Time Factors
chemical_list: D011433:Propranolol
vernacular_title: Farmakokinetika propranolola pri primenenii transdermal'noĭ terapevticheskoĭ sistemy properkutena (éksperimental'nye dannye).