title: Suppressive effects of elimination diets on T cell responses to ovalbumin in hen's egg-sensitive atopic dermatitis patients.
abstract: We investigated the effect of elimination diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after elimination diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after elimination diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after elimination diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that elimination diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.
authors.affiliation: Department of Pediatrics, Gifu University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shinoda
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: O
authors.initials: O
authors.lastname: Fukutomi
authors.forename: H
authors.initials: H
authors.lastname: Agata
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Shimozawa
authors.forename: S
authors.initials: S
authors.lastname: Tomatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Takemura
authors.forename: A
authors.initials: A
authors.lastname: Noma
mesh_terms: D000293:Adolescent; D000954:Antigens, Surface / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000178:diet therapy* / Q000276:immunology; D004531:Eggs / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000178:diet therapy* / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007165:Immunosuppression Therapy; D007223:Infant; D008213:Lymphocyte Activation / Q000276:immunology; D008934:Mitogens / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D010047:Ovalbumin / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D008934:Mitogens; D010047:Ovalbumin