Odontogenic squamous cell carcinoma with osseous metaplasia.
Intra-osseous carcinomas of the jaw are rare tumours, thought to arise from residual elements of the odontogenic epithelium. We report an additional case which, unusually, was characterised by marked osseous metaplasia. We propose that the new bone formed around the tumour is the result of an epithelial-mesenchymal interaction between malignant odontogenic epithelium and osteogenic precursor cells in the surrounding stroma.
Bennett
J H
JH
Department of Oral Pathology, Eastman Dental Hospital, London, England.
Jones
J
J
Speight
P M
PM
D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D008339:Mandibular Neoplasms / Q000473:pathology*; D008679:Metaplasia; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000473:pathology*; D010006:Osteoblasts / Q000473:pathology