Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.
The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD). We have examined epsilon 4 frequencies in four distinct, normal, elderly control groups and, most importantly, in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known (Creutzfeldt-Jakob disease, familial amyloidotic polyneuropathy, Down's syndrome). There were no differences between any of these controls and published control series, cementing the relevance of epsilon 4 for late-onset AD. The increase in late-onset AD was confirmed in two new series.
Saunders
A M
AM
Bryan Alzheimer's Disease Research Center, Division of Neurology, Duke University Medical Center, Durham, NC 27710.
Schmader
K
K
Breitner
J C
JC
Benson
M D
MD
Brown
W T
WT
Goldfarb
L
L
Goldgaber
D
D
Manwaring
M G
MG
Szymanski
M H
MH
McCown
N
N
D000367:Age Factors; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D000686:Amyloidosis / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics; D005787:Gene Frequency; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000235:genetics; D006801:Humans
D053327:Apolipoprotein E4; D001057:Apolipoproteins E