title: A membrane guanylate cyclase Drosophila homolog gene exhibits maternal and zygotic expression.
abstract: A putative membrane form of guanylate cyclase gene was identified in region 32 of the second chromosome of Drosophila melanogaster. The Drosophila protein has a single hydrophobic sequence that divides the protein into a putative extracellular region and a cytoplasmic catalytic region which contains tyrosine kinase and cyclase domains showing varying degrees of conservation with other guanylate and adenylate cyclases. The gene shows a very interrupted organization with small exons separated by small introns and a low level of expression. Transcripts have been localized in situ during oogenesis in the germarium and later in stages 10-14 of egg chamber development. The putative maternal transcript can be seen in very early embryos and reappears later as a product of zygotic gene expression.
authors.affiliation: Istituto Internazionale di Genetica e Biofisica, CNR, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gigliotti
authors.forename: V
authors.initials: V
authors.lastname: Cavaliere
authors.forename: A
authors.initials: A
authors.lastname: Manzi
authors.forename: A
authors.initials: A
authors.lastname: Tino
authors.forename: F
authors.initials: F
authors.lastname: Graziani
authors.forename: C
authors.initials: C
authors.lastname: Malva
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002462:Cell Membrane / Q000201:enzymology; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000302:isolation & purification; D004331:Drosophila melanogaster / Q000235:genetics*; D015870:Gene Expression; D006162:Guanylate Cyclase / Q000032:analysis / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D009928:Organ Specificity; D015053:Zygote / Q000378:metabolism*
chemical_list: D018076:DNA, Complementary; D006162:Guanylate Cyclase