title: The effects of pregnancy on the mouse thymic epithelium.
abstract: Changes in the murine thymus during pregnancy were studied using immunocytochemistry with monoclonal antibodies against thymic epithelial, neuroendocrine, and thymulin-producing cells, fibroblasts, blood vessels and connective tissue components. Extensive alterations occur in mid-pregnancy. The medulla was greatly enlarged in the involuted thymus, and there were greater numbers of epithelial cells. These epithelial cells had an altered distribution forming large structures surrounding spherical masses of mononuclear cells, lacked epithelial cells and often contained a central blood vessel with fibroblasts and connective tissue. We have called these structures 'medullary epithelial rings' (MERs). To our knowledge these structures have not been described before. Late in pregnancy the loss of the central mononuclear cells leaves collapsed structures in a smaller medulla that nevertheless retains many epithelial cells. In virgins and early-pregnancy, there are cortical channels free of epithelial cells that are very infrequent later in pregnancy. This may reflect the loss of steroid-sensitive thymocytes from the cortex. The influence of sex-steroids, neurological impulses and immune activity in causing the changes are discussed, as are the possible consequences in pregnancy of a reduced, thymocyte-depleted cortex and an enlarged medulla that shows great complexity and activity.
authors.affiliation: Department of Obstetrics and Gynaecology, Queen's Medical Centre, University of Nottingham, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Clarke
authors.forename: A L
authors.initials: AL
authors.lastname: Gil
authors.forename: M D
authors.initials: MD
authors.lastname: Kendall
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D004848:Epithelium / Q000033:anatomy & histology / Q000276:immunology / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D013935:Thymic Factor, Circulating / Q000378:metabolism; D013950:Thymus Gland / Q000033:anatomy & histology* / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D013935:Thymic Factor, Circulating