A patient with anaplastic large cell lymphoma (Ki-1 lymphoma) showing clonal integration of HTLV-1 proviral DNA.
We encountered a patient with anaplastic large cell lymphoma (Ki-1 lymphoma) that originated in the stomach and showed histiocytic lymphoma-like morphology. CD43 antigen was positive, and rearrangement of TCR-beta gene was observed. The lymphoma was the T-cell type. Though no atypical lymphocytes or histological images specific to adult T-cell leukemia were observed, clonal integration of HTLV-1 proviral DNA was noted. Viruses such as HTLV-1 appear to be involved in the development of some anaplastic large cell lymphomas.
Takimoto
Y
Y
Department of Internal Medicine, Hiroshima University, Japan.
Tanaka
H
H
Tanabe
O
O
Kuramoto
A
A
Sasaki
N
N
Nanba
K
K
D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015481:HTLV-I Antibodies / Q000032:analysis; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D008297:Male; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology
D004279:DNA, Viral; D015481:HTLV-I Antibodies