[Effect of veinotonyl 75 on the capillary permeability test using technetium albumin in cyclic orthostatic edemas].
The purpose of this trial was to evaluate the clinical effect of Veinotonyl 75 in 42 women, 42 +/- 11 years old, with orthostatic cyclic edema. The main evaluation criterion was the result of a capillary filtration test with 99 mTc albumin which was performed at day 0 and at day 30 after treatment. At day 0, all the women had abnormal results ie an albumin retention > or = 8% (mean: 14.3% +/- 4.8%). At day 30, 75% of the patients were normalized in the Veinotonyl 75 group versus 38% in the placebo group (p < 0.02). The albumin retention in Veinotonyl 75 group was under the pathological level (mean: 5.2% +/- 4.8%) while it was over in the placebo group (mean: 9.4% +/- 7%). This study confirms the activity of Veinotonyl 75 on capillar protein hyperfiltration and on return venous circulation.
Behar
A
A
Service de Biophysique et Médecine Nucléaire, Hôtel-Dieu, Paris, France.
Nathan
P
P
Lavieuville
M
M
Allaert
F A
FA
D000328:Adult; D002199:Capillary Permeability / Q000187:drug effects*; D004311:Double-Blind Method; D004487:Edema / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D008875:Middle Aged; D010507:Periodicity; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
D010936:Plant Extracts; D013668:Technetium Tc 99m Aggregated Albumin; C085954:Veinotonyl 75
Effet du veinotonyl 75 sur le test de perméabilité capillaire a l'albumine technetiée dans les oedèmes cycliques orthostatiques.