Preferential expansion and activation of V beta 5+ CD4+ T cells in murine acquired immunodeficiency syndrome.
Infection of B6 mice with LP-BM5 MuLV results in a syndrome characterized by progressive and profound immunodeficiency, termed murine acquired immunodeficiency syndrome (MAIDS). In this report we show that preferential expansion and activation of V beta 5+ CD4+ spleen cells occurs early in the course of disease, which then progresses to more widespread polyclonal activation of CD4+ T cells. V beta 5 expansion occurs only on infection with MAIDS-associated MuLV and is not observed after infection with other MuLV. The possible role of V beta 5 activation and expansion as a necessary early step in the pathogenesis of MAIDS is discussed.
Selvey
L A
LA
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Morse
H C
HC
Granger
L G
LG
Hodes
R J
RJ
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D016130:Immunophenotyping; D009052:Leukemia Virus, Murine / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D013997:Time Factors
D015703:Antigens, CD; D000956:Antigens, Viral; D016693:Receptors, Antigen, T-Cell, alpha-beta