title: Restriction of T cell receptor variable region in lymph nodes of adult T cell leukemia/lymphoma.
abstract: Adult T cell leukemia/lymphoma (ATLL) is a mature T cell malignancy, especially derived from the CD4 positive T cell. To characterize the T cell, we examined the representation of T cell antigen receptor variable region, using the monoclonal antibodies [beta V 5 (a), beta V 5 (b), beta V 6 (a), beta V 8 (a), beta V 12 (a), alpha V 2 (a), alpha-beta V (a)]. Clinicopathologically we classified the lymph nodes of patients with ATLL into three states (1) human T cell leukemia virus type I (HTLV-I) associated lymphadenitis, reactive state; (2) incipient ATLL, early or pre-neoplastic state; and (3) ATLL, neoplastic state. The lymph nodes of all three states were composed of unvarying CD4 positive T cells. Most of the lymph nodes with ATLL consistently presented alpha V 2 antigen, but no others. In HTLV-I associated lymphadenitis, only a few cells reacted for alpha V 2, as in non-specific lymphadenitis without ATLL features. One of three cases with incipient ATLL presented alpha V 2. The selected expression of T cell antigen receptor V region might be associated with the presence of HTLV-I encoded superantigen, similar to human immunodeficiency virus (HIV).
authors.affiliation: Department of Pathology, School of Medicine, Fukuoka University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Yoneda
authors.forename: S
authors.initials: S
authors.lastname: Kobari
authors.forename: Y
authors.initials: Y
authors.lastname: Sumiyosi
authors.forename: M
authors.initials: M
authors.lastname: Takeshita
authors.forename: N
authors.initials: N
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis* / Q000235:genetics
chemical_list: D004279:DNA, Viral; D016693:Receptors, Antigen, T-Cell, alpha-beta