title: Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic sepsis.
abstract: We studied the mechanisms responsible for the changes in lung lymph flow (QL) in chronic sepsis induced by the continuous infusion of endotoxin [lipopolysaccharide (LPS), 10 ng.kg-1.min-1]. Sheep (n = 11) were studied in the unanesthetized state 7 days after preparation, and cardiopulmonary variables were measured. In the control group (n = 5) given lactated Ringer solution, no significant changes were observed in any measured variables. In the LPS group (n = 6), QL increased from 11.7 +/- 3.8 to 54.0 +/- 15.0 (SE) ml/h 24 h after LPS infusion had begun. This elevation in QL was associated with little or no change (P > 0.05) in reflection coefficient (0.80 +/- 0.03 to 0.87 +/- 0.05) or pulmonary microvascular pressure (14.3 +/- 0.4 to 16.7 +/- 1.2 mmHg). The filtration coefficient, however, was significantly elevated (0.018 +/- 0.006 to 0.083 +/- 0.024 ml.min-1.mmHg-1). In association with changes in QL that occur as a result of LPS administration, there was a significant increase in cardiac index (6.1 +/- 0.5 to 10.2 +/- 0.3 l.min-1.m-2) and a reduction in mean arterial pressure (90.2 +/- 4.4 to 73.7 +/- 7.3 mmHg) and systemic vascular resistance index (1,229 +/- 134 to 583 +/- 62 dyn.s.cm-5.m2), findings similar to those noted in septic humans.
authors.affiliation: Department of Anesthesiology, University of Texas Medical Branch, Galveston.
authors.forename: H
authors.initials: H
authors.lastname: Nakazawa
authors.forename: H
authors.initials: H
authors.lastname: Noda
authors.forename: S
authors.initials: S
authors.lastname: Noshima
authors.forename: J T
authors.initials: JT
authors.lastname: Flynn
authors.forename: L D
authors.initials: LD
authors.lastname: Traber
authors.forename: D N
authors.initials: DN
authors.lastname: Herndon
authors.forename: D L
authors.initials: DL
authors.lastname: Traber
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D002908:Chronic Disease; D015633:Extravascular Lung Water / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D007262:Infusions, Intravenous; D007267:Injections; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008208:Lymphatic System; D011652:Pulmonary Circulation / Q000502:physiology; D012756:Sheep; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D008070:Lipopolysaccharides