Rapid alterations in cAMP accumulation in brain nuclei of rats following microinjections of vasoactive intestinal polypeptide (VIP) into the lateral ventricle.
The in vivo effect of exogenous vasoactive intestinal polypeptide (VIP) on the accumulation of cAMP in 21 microdissected brain nuclei was investigated 3 and 7 min after intraventricular injections in rats. VIP elicited significant (up to 20-fold) increases in cAMP levels. This effect is region specific varying considerably among the brain regions investigated. VIP dramatically increased the cAMP content of the lateral septal nucleus, several hypothalamic nuclei, the habenula, the midbrain central gray and the locus coeruleus. Smaller increases were observed elsewhere including some VIP-rich brain areas such as the cerebral cortex and the hippocampus.
Palkovits
M
M
Laboratory of Neuromorphology, Semmelweis University Medical School, Budapest, Hungary.
Schmid
G
G
Bahner
U
U
Hempel
K
K
Heidland
A
A
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP