title: Fungicidal and genotoxic activity of new substituted pyridazinones.
abstract: Some 2-sulfonyl- and 2-acylderivatives of the 4,5-dichloro-3(2H)-pyridazinone were prepared in order to test their fungicidal activity. Interesting results, both in vitro and in vivo, were obtained in particular from the alkylsulfonyl-derivatives. Genotoxic activity of 3(2H)-pyridazinones was evaluated in vitro by the Bacillus subtilis rec-assay and the Salmonella-microsome reversion assay.
authors.affiliation: Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Carmellino
authors.forename: G
authors.initials: G
authors.lastname: Massolini
authors.forename: G
authors.initials: G
authors.lastname: Pagani
authors.forename: F
authors.initials: F
authors.lastname: Zani
authors.forename: G
authors.initials: G
authors.lastname: Leri
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics; D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D010935:Plant Diseases; D011724:Pyridazines / Q000494:pharmacology* / Q000633:toxicity; D011995:Recombination, Genetic / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D005659:Fungicides, Industrial; D009153:Mutagens; D011724:Pyridazines; C020458:2-phenyl-4,5-dichloro-3-pyridazinone