Effects of implantation of Alzet 1007D osmotic minipumps upon 2-deoxyglucose uptake in the cerebral cortex of mice.
The smallest Alzet osmotic minipumps (1007D) were implanted into mouse cerebral cortex. The flow of saline from a minipump produced a large necrosis of cortical tissue and still larger zone of decreased metabolic activity around the site of cannula implantation. Stimulus evoked uptake of 2-deoxyglucose located several millimeters from the implantation site was not affected.
Jabłońska
B
B
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Gierdalski
M
M
Kublik
A
A
Skangiel-Kramska
J
J
Kossut
M
M
D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D051379:Mice; D010812:Physical Stimulation; D014738:Vibrissae / Q000502:physiology
D003847:Deoxyglucose