title: Determination of 17-hydroxycorticosteroids in dialysate solution as a measure of adrenocortical function in hemodialysis patients.
abstract: Dialysate contents of 17-hydroxycorticosteroids (17-OHCS) in hemodialysis patients were studied as a potential measure of adrenocortical function. Dialysate 17-OHCS contents after a 2-day interval of hemodialysis in 15 hemodialysis patients were determined. Dialysate 17-OHCS increased after intravenous injection of cortisol the evening prior to hemodialysis (n = 4). Dialysate 17-OHCS content was suppressed, as was plasma cortisol, after a standard dexamethasone (Dex) suppression test (n = 1). Their plasma cortisol was suppressible or nonsuppressible by an overnight Dex suppression test, as reported previously. However, basal dialysate 17-OHCS contents were not different between them, indicating that the nonsuppressible patients with overnight Dex seem not to have hypercortisolism. We conclude that determination of dialysate 17-OHCS seems a useful noninvasive technique for the evaluation of adrenocortical function in hemodialysis patients.
authors.affiliation: Third Department of Internal Medicine, Kumamoto University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kohda
authors.forename: R
authors.initials: R
authors.lastname: Hiramatsu
authors.forename: K
authors.initials: K
authors.lastname: Kuwahara
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000032:analysis*; D000302:Adrenal Cortex / Q000503:physiopathology*; D000304:Adrenal Cortex Function Tests / Q000379:methods; D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage; D015314:Dialysis Solutions / Q000737:chemistry*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D015065:17-Hydroxycorticosteroids; D015314:Dialysis Solutions; D003907:Dexamethasone; D006854:Hydrocortisone