title: Surgical management of advanced squamous cell skin cancers.
abstract: Squamous cell cancer of the skin usually follows prolonged exposure to known carcinogens including ultraviolet light, ionizing radiation, chronic infection or irritation, chemicals, and immunologic suppression. The majority of squamous cell skin cancers metastasize infrequently and can be cured with aggressive wide local excision. However, on occasion they can be quite aggressive locally, with or without associated distant metastasis, and may require a radical surgical approach. We report a series of four male patients covering the spectrum of this disease with the following distribution: lower pole of the right ear, right posterior thigh below gluteal fold with positive inguinal nodes, lateral aspect of the foot with bone involvement, and as an incidental finding in a pilonidal cyst. We conclude that one should not hesitate to proceed with aggressive surgical resection as it may provide the only chance for cure. Finally, one should always look for lymph node metastasis, particularly with large (> 5 cm) lesions adjacent to a regional lymph node drainage basin.
authors.affiliation: Department of Surgery, State University of New York at Buffalo 14215.
authors.forename: E L
authors.initials: EL
authors.lastname: Hoover
authors.forename: R
authors.initials: R
authors.lastname: Marrero
authors.forename: H
authors.initials: H
authors.lastname: Bumpers
authors.forename: M
authors.initials: M
authors.lastname: Coles
authors.forename: S
authors.initials: S
authors.lastname: Parsh
authors.forename: R
authors.initials: R
authors.lastname: Doerr
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*