Does high MHC class II gene expression in normal lungs account for the strong immunogenicity of lung allografts?
Clinical experience has demonstrated that lung allografts are considerably more immunogenic than liver allografts although both organs contain equivalent amounts of lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC class II expression in lungs is semiquantitatively higher than in the liver and other organs with the exception of the spleen. We conclude that this high MHC class II expression strongly suggests that the lymphoreticular tissue in the lungs is in a state of activation. This may be an important reason for the strong immunogenicity of lung allografts.
Alwayn
I P
IP
Leiden University Medical School, The Netherlands.
Xu
R
R
Adler
W H
WH
Kittur
D S
DS
D000818:Animals; D015152:Blotting, Northern; D015870:Gene Expression; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D008168:Lung / Q000276:immunology*; D016040:Lung Transplantation / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000378:metabolism; D014184:Transplantation, Homologous
D006183:H-2 Antigens; D015345:Oligonucleotide Probes; D012333:RNA, Messenger