Impaired glucocorticoid induction of mononuclear leukocyte lipocortin-1 in rheumatoid arthritis.
OBJECTIVE
To investigate leukocyte lipocortin-1 production in rheumatoid arthritis (RA).


METHODS
Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin-1 was measured by enzyme-linked immunosorbent assay.


RESULTS
Hydrocortisone induced significant increases in lipocortin-1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin-1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014).


CONCLUSIONS
These results indicate that glucocorticoid-induced MNC lipocortin-1 production is impaired in RA.
Morand
E F
EF
Inflammation Research Group, Bath Institute for Rheumatic Diseases, England.
Jefferiss
C M
CM
Dixey
J
J
Mitra
D
D
Goulding
N J
NJ
D017302:Annexins / Q000096:biosynthesis*; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism
D017302:Annexins; D006854:Hydrocortisone