title: Serotypes and extended spectrum beta-lactam resistance in aminoglycoside resistant Pseudomonas aeruginosa isolates from two Belgian general hospitals: a seven year study.
abstract: A total of 1896 isolates of Pseudomonas aeruginosa resistant to aminoglycosides and isolated during the period 1983-1989 in two Belgian general hospitals were included in this study. The most frequently encountered O serotypes were O4, O11, O12 and non-typable isolates. The majority of the isolates showed resistance to extended spectrum beta-lactam antibiotics (cefotaxime, ceftriaxone and cefepime). However, a low degree of resistance was found for ceftazidime. By contrast, amikacin and isepamicin, remained active on a significant number of aminoglycoside resistant isolates. In both hospitals, impermeability and AAC(3)II enzyme production were the most prevalent aminoglycoside resistance mechanisms. There were marked differences between the two hospitals with regard to the distribution of the O-serotypes and resistance profiles.
authors.affiliation: Unit of Antibiotic Research, Institute Pasteur of Brabant, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Vanhoof
authors.forename: C
authors.initials: C
authors.lastname: Godard
authors.forename: E
authors.initials: E
authors.lastname: Nulens
authors.forename: H J
authors.initials: HJ
authors.lastname: Nyssen
authors.forename: C
authors.initials: C
authors.lastname: Wildemauwe
authors.forename: J M
authors.initials: JM
authors.lastname: Hubrechts
authors.forename: P
authors.initials: P
authors.lastname: Maes
authors.forename: E
authors.initials: E
authors.lastname: Hannecart-Pokorni
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001530:Belgium; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology; D006761:Hospitals; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000187:drug effects*; D012703:Serotyping; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D047090:beta-Lactams; D000583:Amikacin; C016927:isepamicin