[Effects of scorpion injection on interleukin 1 and pathology in experimental glomerulonephritis in situ].
The model of experimental glomerulonephritis in situ in rats was established by administration of C-BSA. 24 male Wistar rats were randomly assigned to three groups: C-BSA, control and C-BSA+scorpion (scorpion injection, ip, 1.0 g/kg, once/day). At the end of 4th week, the bioactivity of serum IL-1 was assayed by thymocyte proliferation method and the renal pathology was checked up. Urine sample was collected for 24 hour once/week for protein determination.


RESULTS
Quantity of proteinuria in scorpion group was reduced significantly in comparing with C-BSA group. Level of IL-1 was significantly lower in scorpion group than that in C-BSA group. Injury of renal tissue also was mild in the treated group. These results suggested that scorpion injection could suppress the activities of IL-1 and ameliorate the pathological injury in this experimental glomerulonephritis in situ.
Zheng
Z H
ZH
Kidney Research Inst., Sun Yat-sen University of Med. Sci., Guangzhou.
Ye
R G
RG
D000818:Animals; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D007375:Interleukin-1 / Q000097:blood*; D007672:Kidney Cortex / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D051379:Mice; D008809:Mice, Inbred C3H; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012605:Scorpions; D012710:Serum Albumin, Bovine
D007375:Interleukin-1; D008419:Materia Medica; D012710:Serum Albumin, Bovine