title: Detection of brain activation using oxygenation sensitive functional spectroscopy.
abstract: A nonwater-suppressed localized spectroscopy experiment using the PRESS-sequence has been used to study the signal changes of the water resonance during cortical activation. Significant effects with an effect-to-noise ratio up to 50:1 for a single shot experiment have been observed upon photic stimulation. The exceedingly high signal-to-noise ratio of the experiment was used to demonstrate signal changes as low as 0.1% after electrical stimulation of the median nerve.
authors.affiliation: Radiologische Klinik, Abt. Röntgendiagnostik, Neurologische Klinik, University Freiburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Hennig
authors.forename: T
authors.initials: T
authors.lastname: Ernst
authors.forename: O
authors.initials: O
authors.lastname: Speck
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: E
authors.initials: E
authors.lastname: Feifel
mesh_terms: D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010775:Photic Stimulation