title: Synthesis and pharmacological evaluation of 7-substituted procaterol derivatives.
abstract: A series of procaterol derivatives having a substituent at the 7-position of the carbostyril moiety was synthesized. Halogenation of procaterol and its homologues gave the 7-halogeno derivatives (3). Nitration of the procaterol analogues afforded the 7-nitro derivatives (4), and the catalytic reduction of 4 gave the 7-amino derivatives (5). These compounds showed weak beta-adrenoceptor stimulant activities in anesthetized dog.
authors.affiliation: Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yoshizaki
authors.forename: S
authors.initials: S
authors.lastname: Tamada
authors.forename: E
authors.initials: E
authors.lastname: Yo
authors.forename: M
authors.initials: M
authors.lastname: Umezato
mesh_terms: D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D017265:Procaterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000318:Adrenergic beta-Agonists; D017265:Procaterol