title: Propofol as an induction agent in the goat: a pharmacokinetic study.
abstract: The pharmacokinetics of propofol, 4 mg/kg, administered as a bolus dose intravenously (i.v.) prior to the maintenance of anaesthesia with halothane in oxygen, were determined in five goats, and a clinical impression of its use as an induction agent was made. Induction of anaesthesia was rapid and smooth, providing satisfactory conditions for intubation in all animals. Post-induction apnoea occurred in one goat and minimal regurgitation of ruminal contents was recorded in two animals. Recovery times were rapid with a mean time to standing after halothane inhalation ceased of 13.7 min. The blood propofol concentration time profile was best described by a bi-exponential decline in all five goats. The mean elimination half-life was short (15.5 min), the volume of distribution at steady state large (2.56 l/kg) and the clearance rapid (275 ml/min.kg). Propofol was shown to be a very satisfactory induction agent in the goat.
authors.affiliation: Department of Veterinary Surgery, University of Glasgow, Veterinary School, UK.
authors.forename: J
authors.initials: J
authors.lastname: Reid
authors.forename: A M
authors.initials: AM
authors.lastname: Nolan
authors.forename: E
authors.initials: E
authors.lastname: Welsh
mesh_terms: D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D002369:Castration / Q000662:veterinary; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005260:Female; D006041:Goats / Q000293:injuries / Q000378:metabolism*; D006207:Half-Life; D006221:Halothane; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013978:Tibial Fractures / Q000601:surgery
chemical_list: D006221:Halothane; D015742:Propofol