title: Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation.
abstract: The pathophysiological mechanisms involved in the development of a spontaneous systemic capillary leak syndrome (CLS) are unknown. In contrast, CLS is a well-known side effect of high-dose interleukin-2 (IL-2) therapy in solid tumors. We report on a patient who developed CLS with high serum levels of endogenous IL-2 under immunosuppressive therapy for chronic graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT). Generalized edema persisted for 10 weeks. The condition resolved after antibiotic therapy of a septic shock with beta hemolyzing streptococci group A. Thus, a latent infection may alter cytokine homeostasis and may cause CLS in BMT patients.
authors.affiliation: Department of Internal Medicine III, University of Ulm, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Funke
authors.forename: O
authors.initials: O
authors.lastname: Prümmer
authors.forename: H
authors.initials: H
authors.lastname: Schrezenmeier
authors.forename: D
authors.initials: D
authors.lastname: Hardt
authors.forename: M
authors.initials: M
authors.lastname: Weiss
authors.forename: F
authors.initials: F
authors.lastname: Porzsolt
authors.forename: R
authors.initials: R
authors.lastname: Arnold
authors.forename: H
authors.initials: H
authors.lastname: Heimpel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002199:Capillary Permeability; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood; D006086:Graft vs Host Disease / Q000628:therapy; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes; D013577:Syndrome; D014184:Transplantation, Homologous
chemical_list: D000900:Anti-Bacterial Agents; D016207:Cytokines; D007376:Interleukin-2