title: Estimation of impurity profiles in drugs and related materials. Part 11--The role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses.
abstract: Impurities in drugs are classified on the basis of the types of side-reactions in drug syntheses resulting in their formation. This is shown by summarizing the authors' earlier results in the field of impurity profiling of 19-nor-steroids, ethynodiol diacetate, mazipredone, pipecuronium bromide, flumecinol, enalapril, pyridinol carbamate, phenylbutazone, thymotrinan and some new results related to danazol and famotidine.
authors.affiliation: Chemical Works of G. Richter Ltd., Budapest, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Görög
authors.forename: G
authors.initials: G
authors.lastname: Balogh
authors.forename: A
authors.initials: A
authors.lastname: Csehi
authors.forename: E
authors.initials: E
authors.lastname: Csizér
authors.forename: M
authors.initials: M
authors.lastname: Gazdag
authors.forename: Z
authors.initials: Z
authors.lastname: Halmos
authors.forename: B
authors.initials: B
authors.lastname: Hegedüs
authors.forename: B
authors.initials: B
authors.lastname: Herényi
authors.forename: P
authors.initials: P
authors.lastname: Horváth
authors.forename: A
authors.initials: A
authors.lastname: Laukó
mesh_terms: D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000138:chemical synthesis* / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004364:Pharmaceutical Preparations