title: Comparison of the effects of whey mineral complexes on bone metabolism in male growing rats.
abstract: The effects of whey mineral complexes (WMC1 and WMC2) on bone metabolism were studied in male growing rats. The contents of Ca, P, and protein in WMC1 were 18.2, 8.4, 2.3%, respectively, whereas those of WMC2 were 26.4, 14.6, and 10.5%, respectively. WMCs were added to diets as a sole source of Ca: the levels of dietary Ca were 0.3 and 0.6%. CaCO3 was used as a reference. There was no difference in body weight gain and quantitative values for Ca balance among the groups at the same level of dietary Ca. Rats fed WMC2 had a higher femoral Ca and bone density of humerus. The bone properties in rats fed WMC1 were not as high as those in rats fed WMC2. The P absorption and absorption rate were affected significantly by the type of dietary Ca source as well as the levels of dietary Ca. The percent of tubular reabsorption of P of rats fed WMC1 or WMC2 had a tendency to be higher than that of rats fed CaCO3 at each dietary Ca level. The results of urinary cAMP excretion showed that the parathyroid hormone function in rats fed WMC2 was relatively lower. The differences in minerals and other constituents between WMC1 and WMC2 are discussed from the viewpoint of bone metabolism.
authors.affiliation: Central Research Institute, Meiji Milk Products Co. Ltd., Higashimurayama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsuchita
authors.forename: I
authors.initials: I
authors.lastname: Sekiguchi
authors.forename: T
authors.initials: T
authors.lastname: Kuwata
mesh_terms: D000818:Animals; D001835:Body Weight; D015519:Bone Density; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000652:urine; D003611:Dairy Products; D004032:Diet; D005269:Femur / Q000737:chemistry / Q000502:physiology*; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D008903:Minerals / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008903:Minerals; D000242:Cyclic AMP; D006909:Hydroxyproline; D002118:Calcium