Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.
We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use of exon 9 splice acceptor sites generated two 5-HT3R variants. The 5-HT3R gene, whose structure is closely related to neuronal and muscle AChR alpha genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.
Uetz
P
P
Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany.
Abdelatty
F
F
Villarroel
A
A
Rappold
G
G
Weiss
B
B
Koenen
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D018076:DNA, Complementary / Q000302:isolation & purification; D005260:Female; D015870:Gene Expression; D018014:Gene Transfer Techniques; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009132:Muscles / Q000737:chemistry; D009474:Neurons / Q000737:chemistry; D009865:Oocytes / Q000378:metabolism; D012326:RNA Splicing; D011985:Receptors, Serotonin / Q000737:chemistry / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014982:Xenopus laevis
D018076:DNA, Complementary; D011985:Receptors, Serotonin