title: [Failure of intravenous immunoglobulins in certain systemic diseases. 5 cases].
abstract: Human polyvalent immunoglobulins administered intravenously have shown to be effective in some immune diseases. We administered high dose-IV Ig (2g/kg/session) in five patients with severe chronic systemic diseases. Their condition did not improve, except in one case where a transient response was noticed. Considering the inconsistent results and high cost of IV Ig, double blind studies are required to determine the conditions in which high dose IV Ig may be more effective than conventional treatments.
authors.affiliation: Service de Médecine Interne, Hôpital Avicenne, Bobigny.
authors.forename: P
authors.initials: P
authors.lastname: Bahadoran
authors.forename: M
authors.initials: M
authors.lastname: De Bandt
authors.forename: M
authors.initials: M
authors.lastname: Echard
authors.forename: B
authors.initials: B
authors.lastname: Jarrousse
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
mesh_terms: D000328:Adult; D003449:Cryoglobulinemia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000188:drug therapy*; D017285:Polymyositis / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D016756:Immunoglobulins, Intravenous
vernacular_title: Echec des immunoglobulines intraveineuses au cours de certaines maladies systémiques. 5 observations.