Gamma Knife radiosurgery in the treatment of ocular melanoma.
Ocular melanoma, the most common primary adult intraocular neoplasm, has a very high morbidity and mortality despite multiple alternative therapies. Consequently, we decided to study Gamma Knife radiosurgery (GKR) for the treatment of ocular melanoma in a clinical trial format. We describe the modifications of standard GKR to treat intraocular tumors, the objective, inclusion and exclusion criteria, treatment parameters, measurement of effect, and statistical evaluation of the clinical trial. The major adverse effects (i.e., cataract, vitreous hemorrhage, blindness, and loss of the eye) of the study are correctable or infrequent, whereas the benefits (i.e., tumor stasis or regression, preservation of sight, lower metastatic potential, and preservation of the globe) are substantial. This study is designed to evaluate GKR as a treatment option for ocular melanoma, although results are not yet available.
Logani
S
S
Department of Ophthalmology, University of California School of Medicine, Los Angeles.
Helenowski
T K
TK
Thakrar
H
H
Pothiawala
B
B
D000328:Adult; D002830:Choroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D016634:Radiosurgery; D015996:Survival Rate; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology