Dose-related increase of HDL-cholesterol levels after N-acetylcysteine in man.
Changes in plasma lipid-lipoprotein levels were evaluated in 10 hyperlipidemic patients during treatment with progressive doses (from 1200 mg day-1 to 3600 mg day-1) of N-acetylcysteine (NAC). Plasma total cholesterol and triglyceride levels, as well as those of lipoprotein (a) did not change to an appreciable extent, even with the highest dosage. However, the HDL-cholesterol levels showed a significant, dose-related rise, the mean absolute increase, with the highest NAC dose, being of approximately 10 mg dl-1 (16.2%). The rise of HDL-cholesterol was independent of changes in other lipid-lipoprotein parameters, suggesting a possible direct effect of NAC on the HDL system.
Franceschini
G
G
Centre E. Grossi Paoletti, University of Milano, Italy.
Werba
J P
JP
Safa
O
O
Gikalov
I
I
Sirtori
C R
CR
D000111:Acetylcysteine / Q000494:pharmacology*; D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D013268:Stimulation, Chemical; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D014280:Triglycerides; D000111:Acetylcysteine