Antidepressant/anxiolytic ipsapirone inhibits cold-induced hypothalamic TRH release.
Acute administration of the serotonin (5-HT)1A receptor agonist ipsapirone has been previously shown to elicit a dose-dependent decrease of cold-elicited thyrotropin (TSH) secretion. Therefore, the aim of the present study was to evaluate, by means of a push-pull cannula implanted in the median eminence (ME), whether ipsapirone acts primarily through an inhibition of cold-elicited thyrotropin-releasing hormone (TRH) release. Ipsapirone administration (10 mg kg-1 i.p., 30 min before cold) prevented cold-elicited TRH release, thereby confirming the above hypothesis. In addition, this study further validates push-pull perfusion in the ME as a key tool for measuring TRH secretion in vivo.
Broqua
P
P
Laboratoire de Pharmacologie, CNRS URA 1482, CHU Necker-E.M., Paris, France.
Benyassi
A
A
Grouselle
D
D
Arancibia
S
S
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003080:Cold Temperature; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008473:Median Eminence / Q000502:physiology; D010477:Perfusion; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D013973:Thyrotropin-Releasing Hormone; C043077:ipsapirone