title: [Structure-activity relationship of synthetic and semisynthetic opioid agonists and antagonists].
abstract: This account presents the chemical structure-pharmacological activity relationships of semi-synthetic morphine and synthetic morphinan and benzomorphan derivatives. Substitution of nitrogen confers the analgesic or morphine antagonist activity. Opiate receptor selectivity of these compounds is also discussed. The importance of morphine agonists, and antagonists is mentioned with particular reference to the opiate receptor mapping.
authors.affiliation: Alkaloida Gyógyszergyár, Tiszavasvári.
authors.forename: S
authors.initials: S
authors.lastname: Hosztafi
authors.forename: T
authors.initials: T
authors.lastname: Friedmann
authors.forename: Z
authors.initials: Z
authors.lastname: Furst
mesh_terms: D015394:Molecular Structure; D009022:Morphine Derivatives / Q000737:chemistry*; D009292:Narcotic Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D009294:Narcotics / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D009022:Morphine Derivatives; D009292:Narcotic Antagonists; D009294:Narcotics; D011957:Receptors, Opioid
vernacular_title: Hatás-szerkezet összefüggések a szintetikus és félszintetikus opioid agonisták és antagonisták körében.