title: [In vitro resistance of Plasmodium falciparum strains isolated in the south of the Pará state, in different periods: occurrence of cases of multiple resistance].
abstract: The responses of Plasmodium falciparum to antimalarial drugs were evaluated through the in vitro test using blood sample collected from patients of 7 municipalities of the south of Pará State. Sixty nine microtests for chloroquine and mefloquine, 62 for amodiaquine and 61 for quinine were performed. The results showed a high resistance for chloroquine (71%), a relatively low resistance level for amodiaquine (25.8%) and little resistance to quinine (8.2%). For mefloquine 100% of sensitivity was found.
authors.affiliation: Programa de Malária, Instituto Evandro Chagas/Fundação Nacional de Saúde, FNS.
authors.forename: A A
authors.initials: AA
authors.lastname: Couto
authors.forename: V S
authors.initials: VS
authors.lastname: Calvosa
authors.forename: M A
authors.initials: MA
authors.lastname: Santos
authors.forename: J M
authors.initials: JM
authors.lastname: Souza
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001938:Brazil; D004351:Drug Resistance; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000962:Antimalarials
vernacular_title: Resistência in vitro de cepas do Plasmodium falciparum isoladas no sul do Estado do Pará, em diferentes períodos: emergência de casos de multirresistência.