DNA topoisomerases from Streptomyces noursei: influence of coumarins and quinolones on the enzymic activity.
DNA topoisomerases have been purified from Streptomyces noursei. DNA gyrase and topoisomerase I show a differential sensitivity against quinolones and coumarins compared to the E. coli enzymes. Streptomyces gyrase is resistant to much higher levels of various drugs than is the E. coli enzyme. The observed differences between the gyrases from streptomycetes and E. coli are discussed in the light of present literature data.
Störl
K
K
Department of Molecular Biology, University of Jena, Germany.
Störl
J
J
Roth
M
M
Zimmer
C
C
D003374:Coumarins / Q000494:pharmacology*; D004264:DNA Topoisomerases, Type I / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000254:growth & development; D015363:Quinolones / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D013379:Substrate Specificity; D059005:Topoisomerase II Inhibitors
D003374:Coumarins; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II