title: Interstitial irradiation for newly diagnosed or recurrent malignant gliomas: preliminary results.
abstract: The preliminary results obtained in 19 patients treated with interstitial irradiation for malignant gliomas are reported. Three different groups are included in the study: I Newly diagnosed tumours not suitable for surgery: 13 cases (10 anaplastic astrocytomas (AA) and 3 glioblastomas (GBM), mean volume 46.56 cc, source Ir 192) were implanted permanently (n = 11, mean peripheral dose 93.54 Gy) or temporarily (n = 2, 50 Gy = 0.5 Gy/hr). External beam irradiation was additionally applied in all cases. II Residual or recurrent tumours: 5 patients (2 AA and 3 GBM, mean volume 7.2 cc, source Ir 192) received temporary implants (150 Gy peripheral dose = 1.5 Gy/hr) after surgery and conventional radiotherapy. III Newly diagnosed surgically removable tumours: only one patient with AA (15 cc volume, source Ir 192) received temporary implantation with the same dose regimen used in Group II before surgery and external beam irradiation. A median survival time of 26.75 mos (34.62 mos for AA, with 3 long-term survivors) was observed in the patients of Group I. Three patients of Group II are still alive after 8, 12 and 12 mos after brachytherapy, the other 2 (GBM) survived 7 and 12 mos. The single patient so far included in Group III is still alive after 6 mos. Although the study is still in progress, these preliminary data seem to indicate that interstitial radiotherapy can be effective in prolonging survival of patients with malignant gliomas.
authors.affiliation: Institute of Neurosurgery, Catholic University, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Scerrati
authors.forename: R
authors.initials: R
authors.lastname: Roselli
authors.forename: P
authors.initials: P
authors.lastname: Montemaggi
authors.forename: M
authors.initials: M
authors.lastname: Iacoangeli
authors.forename: A
authors.initials: A
authors.lastname: Prezioso
authors.forename: G F
authors.initials: GF
authors.lastname: Rossi
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D013238:Stereotaxic Techniques; D016896:Treatment Outcome