title: [Indications spectrum for beta-1-selective adrenergic receptor blockers].
abstract: The major indications for beta receptor blockers include, in addition to arterial hypertension, various clinical manifestations of coronary heart disease. Used as antihypertensive agents, beta receptor blockers bring about regression of myocardial hypertrophy and an improvement in diastolic ventricular function. Anti-anginal effects are utilized in the treatment of symptomatic and asymptomatic myocardial ischemia, as well as for secondary prophylaxis after acute myocardial infarction. A detailed knowledge of the subtypes of adrenoceptors--in particular beta-1 receptors in the case of the heart--led to the development of largely organ-specific antagonists. In contrast to nonspecific beta blockers, beta-1 selective substances, for example, atenolol, have only a mild, clinically non-relevant, effect on glucose and lipid metabolism.
authors.affiliation: Krankenhaus München-Perlach.
authors.forename: F
authors.initials: F
authors.lastname: Dotzer
authors.forename: H
authors.initials: H
authors.lastname: Gromer
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D001262:Atenolol / Q000009:adverse effects / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D018342:Receptors, Adrenergic, beta-1 / Q000502:physiology
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D018342:Receptors, Adrenergic, beta-1; D001262:Atenolol
vernacular_title: Indikationsspektrum beta-1-selektiver Adrenorezeptorenblocker.