[The effect of chorionic gonadotropin on the formation of a secondary immune response].
Investigations have been carried out in experimental systems in vivo on noncastrated and ovariectomized female [correction of male] mice and in vitro. The secondary immune response to sheep erythrocytes has been estimated on the 5-th day after reimmunization by IgM and IgG levels in the antibody-forming cells (AFC). It has been established, that in a dose of 40, IU, chorionic gonadotropin (CG) does not influence the formation of a secondary immune response. All the effects of the hormone are associated with the dose of 200 IU, extrapolated from the maximum CG level during pregnancy. CG in this dose reduces spleen cellularity and suppresses the PFC formation processes. Ovarian sexual steroids do not mediate CG immunodepressive effects, but they are able to abolish the effect of G-AFC depression. An hour preincubation of CG (200 IU) with sensitized splenocytes in vitro suppresses M-AFC formation processes. So, if CG (200 IU) interacts with immunocompetent cells before their repeated contact with antigen, the M-AFC counts decreases; after reimmunization the G-AFC counts decreases.
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D007114:Immunization; D007156:Immunologic Memory / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D010052:Ovariectomy; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D006063:Chorionic Gonadotropin
Vliianie khorionicheskogo gonadotropina na formirovanie vtorichnogo immunnogo otveta.