title: Noninvasive evaluation of the influence of aortic wave reflection on left ventricular ejection during auxotonic contraction.
abstract: To develop a noninvasive method for evaluating the influence of aortic wave reflection on left ventricular ejection, the carotid pulse wave and the pulsed Doppler wave in the left ventricular outflow tract were evaluated in 35 patients. Agreement between the pulsed Doppler waveform and the aortic flow velocity contour (obtained invasively) was verified by Fourier analysis. The carotid augmentation index was used to determine the magnitude of the aortic pressure wave reflection. A Doppler index named "DR1/3" was defined as the ratio of deceleration at the first one-third in the deceleration phase to the peak flow velocity of the pulsed Doppler. This index was validated by close correlation with the carotid augmentation index (n = 48, r = 0.70, P < 0.01). Both nitrates and nifedipine induced a significant decrease in DR1/3 (indicating an increase in left ventricular ejection flow) in relation to a reduction of the reflected pressure wave. The new noninvasive index, DR1/3, is useful in evaluating the influence of aortic wave reflection as part of the left ventricular afterload and in assessing the benefit of treatment aimed at reducing wave reflection.
authors.affiliation: Department of Cardiology, Jichi Medical School, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyashita
authors.forename: U
authors.initials: U
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuruya
authors.forename: H
authors.initials: H
authors.lastname: Sekiguchi
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Yaginuma
mesh_terms: D001011:Aorta / Q000502:physiology*; D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology; D002339:Carotid Arteries / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D011673:Pulsatile Flow; D011674:Pulse; D013318:Stroke Volume / Q000502:physiology*; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents