Congo red inhibition of scrapie agent replication.
Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.
Caughey
B
B
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840.
Ernst
D
D
Race
R E
RE
D000818:Animals; D003224:Congo Red / Q000633:toxicity*; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D051379:Mice; D009447:Neuroblastoma; D018620:PrPSc Proteins; D011328:Prions / Q000096:biosynthesis* / Q000187:drug effects* / Q000302:isolation & purification; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects*
D008562:Membrane Glycoproteins; D018620:PrPSc Proteins; D011328:Prions; D003224:Congo Red