Plasma levels of fenbendazole metabolites in buffalo and cattle after long-term intraruminal administration.
Plasma metabolite levels were measured in buffalo and cross-bred cattle after daily intraruminal administration of fenbendazole at 0.5 mg/kg body weight. An equilibrium between the absorption of fenbendazole and disposition of its metabolites could be observed between days 3 to 6 and remained almost unchanged thereafter. The buffaloes had a lower uptake of the anthelmintic and lower plasma levels of its metabolites than in cattle. The findings were compared with those obtained after a single intraruminal therapeutic dose of fenbendazole.
Sanyal
P K
PK
Animal Disease Research Laboratory, National Dairy Development Board, Gujarat, India.
D000042:Absorption; D000818:Animals; D001562:Benzimidazoles / Q000032:analysis; D002020:Buffaloes / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005273:Fenbendazole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D007267:Injections / Q000662:veterinary; D008137:Longitudinal Studies; D008297:Male; D012417:Rumen
D001562:Benzimidazoles; D005273:Fenbendazole; C011030:oxfendazole