title: IgG avidity assay for estimation of the time after onset of hantavirus infection in colonized and wild bank voles.
abstract: An immunoglobulin G avidity assay was used to determine recent and past hantavirus infection in bank voles (Clethrionomys glareolus). Sera of experimentally infected bank voles were studied at different time intervals. The avidity of specific IgG increased over time after infection. This experimental data were used to estimate the time after onset of hantavirus infection in naturally infected bank voles caught in an endemic area. The possibility to discriminate between recently infected animals and animals infected some time ago is important since the proportion of recently infected bank voles represents the intensity of the epizootic which in turn correlates to the risk of humans to contract the disease.
authors.affiliation: Russian Academy of Medical Science (RAMS), Institute of Poliomyelitis and Viral Encephalitides, Moscow.
authors.forename: I
authors.initials: I
authors.lastname: Gavrilovskaya
authors.forename: N
authors.initials: N
authors.lastname: Apekina
authors.forename: N
authors.initials: N
authors.lastname: Okulova
authors.forename: V
authors.initials: V
authors.lastname: Demina
authors.forename: A
authors.initials: A
authors.lastname: Bernshtein
authors.forename: Y
authors.initials: Y
authors.lastname: Myasnikov
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D000835:Animals, Wild; D000914:Antibodies, Viral / Q000097:blood*; D000915:Antibody Affinity; D003411:Arvicolinae; D004199:Disease Vectors; D005455:Fluorescent Antibody Technique; D006480:Hemorrhagic Fever with Renal Syndrome / Q000175:diagnosis / Q000662:veterinary*; D007074:Immunoglobulin G / Q000097:blood*; D012376:Rodent Diseases / Q000175:diagnosis* / Q000276:immunology; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G