title: Comparison of diode and argon laser trabeculoplasty in cadaver eyes.
abstract: OBJECTIVE
  To evaluate differences in the effects of diode and argon trabeculoplasty on cadaver eye trabecular meshwork.
  
  
  METHODS
  The argon laser was used at a 50 mu spot size, 500 to 100 mW of power, and a 0.1 second time interval, and the diode laser was used at a 0.1 to 0.2 second time interval, 100 mu spot size, and 400 to 1200 mW of power. Analysis was performed using videography, microscopy, and scanning electron microscopy.
  
  
  RESULTS
  This study found grossly that burns with the argon laser caused tissue blanching and pigment dispersion, whereas no reaction was observed with the diode laser. The diode laser made no observable histologic alterations, but the argon caused fragmentation and coagulation of trabecular beams. Scanning electron microscopy showed that the diode laser caused an area of trabecular beam coalescence measuring 50 to 100 mu in diameter with energies > or = 0.12 J. A surrounding zone of more superficial trabecular beam fragmentation measuring 200 to 400 mu in diameter also was observed. Similar energy levels from the argon laser caused hole formation 200 to 400 mu in diameter. Lower argon energy levels (0.05 J) caused inconsistent coalescence 50 to 100 mu in diameter similar to the diode laser.
  
  
  CONCLUSIONS
  This study suggests that in the trabecular meshwork the diode laser causes a reaction at, but not at less than, energy levels shown previously to produce a clinical ocular hypotensive effect. Also, at similar energy per area, the tissue effects of the diode and argon laser are comparable.
authors.affiliation: Department of Ophthalmology, Medical University of South Carolina, Charleston 29425-2236.
authors.forename: T A
authors.initials: TA
authors.lastname: McMillan
authors.forename: W C
authors.initials: WC
authors.lastname: Stewart
authors.forename: U F
authors.initials: UF
authors.lastname: Legler
authors.forename: T
authors.initials: T
authors.lastname: Powers
authors.forename: M J
authors.initials: MJ
authors.lastname: Nutaitis
authors.forename: D J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D001128:Argon; D005126:Eye Burns / Q000473:pathology*; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation*; D008855:Microscopy, Electron, Scanning; D010857:Pigment Epithelium of Eye / Q000601:surgery / Q000648:ultrastructure; D014129:Trabecular Meshwork / Q000601:surgery* / Q000648:ultrastructure; D014130:Trabeculectomy / Q000379:methods; D014741:Video Recording
chemical_list: D001128:Argon