Hepatobiliary changes in Nigerians with sickle cell anaemia.
The histology of a liver specimen from the autopsy of each of 58 sickle cell anaemia patients aged 3-45 years was examined. Sinusoidal distension (present in all specimens), haemosiderosis and erythrophagocytosis (56), portal triaditis (47), cholestasis (24), focal necrosis and fibrosis (23), and extra-medullary erythropoiesis (3) were observed. The livers from the older patients (30-45 years) showed severe haemosiderosis, chronic inflammation, pigment stones and fatty change.
Aken'ova
Y A
YA
Department of Haematology, College of Medicine, University of Ibadan, Nigeria.
Olasode
B J
BJ
Ogunbiyi
J O
JO
Thomas
J O
JO
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002780:Cholestasis, Intrahepatic / Q000473:pathology; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D006486:Hemosiderosis / Q000150:complications / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009549:Nigeria