title: Adrenocortical carcinoma--diagnostic and therapeutical implications.
abstract: OBJECTIVE
  To evaluate the results of treatment of a consecutive series of patients with adrenocortical carcinoma who presented during the six year period 1985 to 1991.
  
  
  METHODS
  Open study.
  
  
  METHODS
  Departments of Surgery, Pathology, Endocrinology, and Clinical Chemistry, Sahlgren Hospital, Göteborg, Sweden.
  
  
  METHODS
  10 consecutive patients, two with recurrent and eight with primary adrenocortical carcinoma.
  
  
  METHODS
  All patients were treated surgically. Two required preoperative embolisation of the tumour vessels to facilitate excision of particularly large tumours, and eight were given adjuvant treatment with mitotane (o,p'-DDD).
  
  
  RESULTS
  At a median follow up of 1.5 years (range 3 months, to 21 years) 6 patients were alive with no radiological or biochemical signs of disease; 2 were alive, but with signs of recurrence (at 3 months and 6 years, respectively); and two had died of their disease (at 4 and 8 months, respectively). For the past two years all patients have had their urinary steroid profiles monitored by gas chromatography and mass spectrometry to detect recurrence of the tumour at the earliest possible stage.
  
  
  CONCLUSIONS
  Operation is the treatment of choice for patients with adrenocortical carcinoma, particularly stages I-III. The role of mitotane as adjuvant treatment can be evaluated only in multicentre studies.
authors.affiliation: Department of Surgery, Sahlgren Hospital, Göteborg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Ahlman
authors.forename: S
authors.initials: S
authors.lastname: Jansson
authors.forename: B
authors.initials: B
authors.lastname: Wängberg
authors.forename: L E
authors.initials: LE
authors.lastname: Tisell
authors.forename: T
authors.initials: T
authors.lastname: Scherstén
authors.forename: G
authors.initials: G
authors.lastname: Hansson
authors.forename: B A
authors.initials: BA
authors.lastname: Bengtsson
authors.forename: I
authors.initials: I
authors.lastname: Ernest
authors.forename: C E
authors.initials: CE
authors.lastname: Jakobsson
authors.forename: S
authors.initials: S
authors.lastname: Lindstedt
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D000314:Adrenal Rest Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008939:Mitotane / Q000627:therapeutic use; D009362:Neoplasm Metastasis
chemical_list: D008939:Mitotane