Widespread deficits in somatostatin but not neuropeptide Y concentrations in Alzheimer's disease cerebral cortex.
Somatostatin-like immunoreactivity (SLI) and neuropeptide Y-like immunoreactivity (NPYLI) were measured in the cerebral cortex of 49 patients with Alzheimer's disease (AD), and 9 elderly controls. Concentrations of SLI were lower in AD patients relative to controls in 9 of 10 cortical regions. In contrast, no significant differences in NPYLI concentrations between the two groups were observed in any of 10 regions. These studies suggest a dissociation between SLI deficits and NPYLI concentrations in the postmortem cerebral cortex of AD patients. The apparent sparing of NPYLI-containing neurons suggests that neuropeptide Y may be located within a separate group of neurons compared to somatostatin.
Gabriel
S M
SM
Departments of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
Bierer
L M
LM
Harotunian
V
V
Purohit
D P
DP
Perl
D P
DP
Davis
K L
KL
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D002102:Cadaver; D002540:Cerebral Cortex / Q000378:metabolism*; D006801:Humans; D007106:Immune Sera; D007231:Infant, Newborn; D009478:Neuropeptide Y / Q000378:metabolism*; D009994:Osmolar Concentration; D011863:Radioimmunoassay; D012016:Reference Values; D013004:Somatostatin / Q000172:deficiency*; D014018:Tissue Distribution
D007106:Immune Sera; D009478:Neuropeptide Y; D013004:Somatostatin