[The relation between Behçet's disease and interleukin-1 beta production].
Interleukin-1 beta (IL-1 beta) is an inflammatory cytokine. We measured its production in 21 Behçet's disease patients, 4 healthy controls, and 4 sarcoidosis patients, by enzyme-linked immunosorbent assay (ELISA) after stimulation with lipopolysaccharide from peripheral blood monocytes. IL-1 beta production of the posterior segment type was significantly greater (p < 0.001) than in healthy controls, sarcoidosis patients, and anterior segment type. In all posterior segment type cases, IL-1 beta production in the active period was greater than in the remission period. IL-1 beta production is considered to be related to posterior segment type attacks of Behçet's disease.
Katayama
T
T
Department of Ophthalmology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Tachinami
K
K
Ishiguro
M
M
Kubota
Y
Y
D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology
D007375:Interleukin-1