[Late anatomical lesions after cardiac transplantation. Study of 44 autopsies beyond 6-months survival].
The aim of this study was to attempt to determine which anatomical lesions were found late after cardiac transplant and could be fatal. A series of 44 autopsies, beyond a 6 month survival time, revealed the types of cardiac and extra-cardiac lesions encountered. They were viewed in the context of clinical findings. Three lesion patterns accounted for more than 9 cases out of 10: coronary disease affecting the transplant (accelerated atherosclerosis or chronic cardiac rejection: 48% of cases), infectious lesions (29%), more than half of which were due to aspergillosis, and neoplasia (14%), favourised by immune-depression. Three results show that graft coronary disease is currently the essential long term problem in the many patients who survive the early postoperative period of cardiac transplant.
Loire
R
R
Hôpital Louis Pradel, Lyon.
Tabib
A
A
Roux
N
N
D000328:Adult; D000368:Aged; D001344:Autopsy; D003327:Coronary Disease / Q000209:etiology / Q000473:pathology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007239:Infections / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors
Lésions anatomiques tardives après transplantation cardiaque. Etude de 44 autopsies au-delà de six mois de survie.