[Effects of Ilexonin A on chemical salpingitis induced tubal obstruction in rats].
Ilexonin A, a new drug in improving the blood circulation and microcirculation, is extracted from Ilicis pubescentis. The preventive and therapeutic effects of Ilexonin A on chemical salpingitis induced tubal obstruction (CSTO) with morphological and hemorheological change in rats was studied. Results showed that Ilexonin A was effective in treating (CSTO by oppositing the degeneration and necrosis of epithelium, inhibiting the hyperplasia of connective tissue, and reducing the infiltration of inflammatory cells. The improvement of morphology was more significant in treated groups than that in controls (P < 0.05-0.01). The indices concerning model rat's hemorheology were also analysed between treated groups and controls. It indicated that Ilexonin A could improve the viscosity of blood and aggregation of red blood cells. It is suggested Ilexonin A could promote the absorption of inflammatory substances as a result of improving hemorheology.
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Dept. of Gynecology, Guangdong Provincial TCM Hospital, Guangzhou.
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D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D008297:Male; D009930:Organic Chemicals; D010636:Phenols; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012488:Salpingitis / Q000139:chemically induced / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D009930:Organic Chemicals; D010636:Phenols; D010975:Platelet Aggregation Inhibitors; C043587:ilexonin A