[The modulation of the function of the immunocompetent system and of nonspecific body resistance in rats with different ratios of essential fatty acids in the diet].
The influence of dietary essential fatty acids on the immune functions and nonspecific resistance of male Wistar rats weighing 135.0 +/- 3.2 g was investigated after 3 months feeding. Rats were fed isocaloric purified diets containing 24% of fat (combinations of lard, sunflower oil and fish oil, eiconol, this providing the ratios of omega 6/omega 3 fatty acids equal to 1.1; 2.1; 6.1; and 49.0. An increase of immune responsiveness and nonspecific resistance in the groups fed diets with the minimal ratios of omega 6/omega 3 fatty acids as compared to that in rats fed a diet with ratio 49.0 was noted. Fatty acid analysis of peripheral lymphoid organs tissue lipids showed an increase in percentage of eicosenic omega 3 fatty acids in rats fed diets with increased content of polyunsaturated fatty acids omega 3.
Volgarev
M N
MN
Levachev
M M
MM
Trushchina
E N
EN
Sergeeva
K V
KV
Kulakova
S N
SN
Aseeva
L E
LE
Mustafina
O K
OK
Tokareva
T V
TV
D000818:Animals; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D007113:Immunity, Innate / Q000187:drug effects*; D007121:Immunocompetence / Q000187:drug effects*; D008297:Male; D010938:Plant Oils; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D010938:Plant Oils; D000074242:Sunflower Oil; C029310:lard
Moduliatsiia sostoianiia immunokompetentnoĭ sistemy i nespetsificheskoĭ rezistentnosti organizma krys razlichnymi sootnosheniiami éssentsial'nykh zhirnykh kislot ratsiona.