[Kinetic changes of thymocyte responsiveness in vitro after thermal injury].
A kinetic observation of responsiveness of thymocytes stimulated by ConA in vitro was made in severe scalded mice. The N-beta-acetylglucosaminidase (NAG) activity and DNA synthesis of thymocyte decreased significantly within 24 hours after burn and NAG activity increased obviously at 48 hours after burn. The alteration of IL-2 produced by thymocytes was in the reverse direction. The early depression of NAG activity and DNA synthesis may be the direct action of scald, and the subsequent increase may be resulted from the compensation of thymocytes. The significant suppression of IL-2 production at 72 hours after burn indicated that the decompensation of thymocytes had occurred. Therefore, the changes of responsiveness of thymocytes in vitro might affect the development and maturation of T cells and the cell-mediated immunity of the body.
Peng
D Z
DZ
Burn Research Institute, Southwest Hospital, Third Military Medical University, Chongqing.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D002056:Burns / Q000276:immunology*; D004247:DNA / Q000096:biosynthesis; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D007376:Interleukin-2; D004247:DNA; D000118:Acetylglucosaminidase