Chirality of methamphetamine and amphetamine from workplace urine samples.
Several positive methamphetamine/amphetamine urine samples were reexamined to determine the chirality of the detected drug or drugs. (S)-N-(Trifluoroacetyl)prolyl derivatives were prepared and analyzed using GC/MS. In one case, pure d-isomers of methamphetamine and amphetamine were detected. In the remainder of the samples involving both drugs, skewed racemates were detected, with the l-isomer of methamphetamine and the d-isomer of amphetamine predominating slightly over their enantiomers. In samples involving amphetamine only, 50:50 mixtures of d- and l-isomers were detected. In no instance was pure i-methamphetamine (from a Vicks inhaler) detected.
Cooke
B J
BJ
Harrison & Associates Forensic Laboratories, Midland, TX 79702.
D000661:Amphetamine / Q000652:urine*; D003913:Dextroamphetamine / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008694:Methamphetamine / Q000652:urine*; D013237:Stereoisomerism; D015813:Substance Abuse Detection / Q000379:methods*; D017132:Workplace
D008694:Methamphetamine; D000661:Amphetamine; D003913:Dextroamphetamine