title: Ligand binding characteristics of [3H] dihydroalprenolol in cerebral cortical membranes of young and old senescence-accelerated mouse.
abstract: 1. The values of both Kd and Bmax of [3H] dihydroalprenolol binding in the cerebral cortical membranes of old-aged (12 month old) SAM-P/1 were not significantly different compared with those of young (2 month old) SAM-P/1. 2. The values of Ki of metoprolol in the young and old aged SAM were 119 +/- 39.5 nM and 157 +/- 55 nM, respectively. 3. The values of beta 1/beta 2 ratio of the young and old aged SAM were 1.67 +/- 0.15 and 1.64 +/- 0.13, respectively. 4. These results suggest that there were no significant changes of binding characteristics of beta 1 and beta 2 adrenoceptors during aging in the cerebral cortex of SAM.
authors.affiliation: Department of Pharmacology, College of Medicine, Seoul National University, Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Suh
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Kim
authors.forename: W
authors.initials: W
authors.lastname: Choi
authors.forename: C W
authors.initials: CW
authors.lastname: Park
authors.forename: M H
authors.initials: MH
authors.lastname: Chung
authors.forename: J K
authors.initials: JK
authors.lastname: Lim
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004082:Dihydroalprenolol / Q000378:metabolism*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D051379:Mice; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D008790:Metoprolol