title: [Extra-abdominal fibromatosis. An immunohistochemical analysis].
abstract: A 49-year-old patient presented with a slow-growing tumour on his back, which had been present for 10 years. Histologically an infiltrating spindle-cell tumour without cell polymorphism was found. Each cell was surrounded by collagen fibrils. Immunohistochemically the tumour cells showed positive staining with antibodies to alpha-smooth muscle actin, factor XIIIa, CD34 and vimentin. In contrast, antibodies to the intermediate filament protein desmin, glial fibrillary acid protein (GFAP), the neurofilament (NF), neuron-specific enolase (NSE), S-100 protein, carcinoembryonic antigen (CEA) and keratin protein (LU-5) revealed no staining of the spindle cells. This immunohistochemical profile supports myofibroblastic differentiation of the spindle cell in extra-abdominal fibromatosis.
authors.affiliation: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
authors.forename: C G
authors.initials: CG
authors.lastname: Schirren
authors.forename: H
authors.initials: H
authors.lastname: Schirren
authors.forename: B
authors.initials: B
authors.lastname: Gyzicki-Nienhaus
authors.forename: P
authors.initials: P
authors.lastname: Kind
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D013524:Surgical Flaps
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Extraabdominale Fibromatose. Eine immunhistochemische Analyse.