title: [Enterosorbent with immobilized trimethylaminoethanol chloride. I. Hypolipidemic properties].
abstract: Hypolipidemic properties of the synthesized enterosorbent, water soluble polymer containing covalently immobilized trimethylamine ethanol chloride, were studied. Content of cholesterol in blood was decreased by 29% and accumulation of cholesterol in liver tissue--by 22% after oral administration of the enterosorbent at a dose of 250 mg/kg into rats with hypercholesterolemia. Cholestyramine exhibited the similar effect only at a dose of 2.5 g/kg. Except for the hypocholesterolemic effect, the enterosorbent altered also the lipoprotein spectrum in rat blood serum.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Lopukhin
authors.forename: I P
authors.initials: IP
authors.lastname: Andrianova
authors.forename: V E
authors.initials: VE
authors.lastname: Ryzhenkov
authors.forename: N A
authors.initials: NA
authors.lastname: Samoĭlova
authors.forename: A M
authors.initials: AM
authors.lastname: Chistiakova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Frolova
authors.forename: I A
authors.initials: IA
authors.lastname: Iamskov
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
authors.forename: Ia I
authors.initials: IaI
authors.lastname: Lapuk
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D016061:Enterosorption / Q000379:methods*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats
chemical_list: D000960:Hypolipidemic Agents; D000644:Quaternary Ammonium Compounds; D002784:Cholesterol
vernacular_title: Enterosorbent s immobilizovannym khloridom trimetilaminoétanola. I. gipolipidemicheskie svoĭstva.