BK virus infection of the human urinary tract.
By screening consecutive autopsy cases with an antibody that recognizes human polyomaviruses, we found a case of malignant lymphoma in which the virus infection was confined to epithelia of the renal calyces, renal pelvis, ureter, and urinary bladder. The virus was confirmed as BK virus by a specific monoclonal antibody against BK virus T antigen, and numerous virus particles were identified by electron microscopy. The results showed that BK virus is a human urotheliotrophic virus.
Shinohara
T
T
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Matsuda
M
M
Cheng
S H
SH
Marshall
J
J
Fujita
M
M
Nagashima
K
K
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000276:immunology; D000952:Antigens, Polyomavirus Transforming / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001739:BK Virus / Q000276:immunology / Q000302:isolation & purification* / Q000648:ultrastructure; D002213:Capsid / Q000276:immunology; D036022:Capsid Proteins; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007577:JC Virus / Q000276:immunology; D008223:Lymphoma / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000382:microbiology* / Q000473:pathology; D013045:Species Specificity; D014412:Tumor Virus Infections / Q000382:microbiology* / Q000473:pathology; D014551:Urinary Tract / Q000382:microbiology* / Q000473:pathology; D014571:Urologic Neoplasms / Q000382:microbiology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000952:Antigens, Polyomavirus Transforming; D000956:Antigens, Viral; D036022:Capsid Proteins; C062481:VP1 protein, polyomavirus