Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine.
Methdilazine (Md) could inhibit various Mycobacterium spp. at 5-15 micrograms/ml concentrations in vitro as well as in vivo. When Md was tested in combination with streptomycin (Sm), rifampicin (Rf) or methyl-DOPA (m-D), it showed synergistic effects only with respect to methyl-DOPA.
Chakrabarty
A N
AN
Department of Medical Microbiology and Parasitology, Calcutta University College of Medicine, India.
Bhattacharya
C P
CP
Dastidar
S G
SG
D000818:Animals; D004347:Drug Interactions; D006634:Histamine H1 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D010640:Phenothiazines / Q000494:pharmacology* / Q000627:therapeutic use; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D014376:Tuberculosis / Q000188:drug therapy
D006634:Histamine H1 Antagonists; D010640:Phenothiazines; C044642:methdilazine; D008750:Methyldopa; D012293:Rifampin; D013307:Streptomycin