Muscimol-induced increase in dopamine release and metabolism is not observed in kainic acid-lesioned striatum of conscious rats: an in vivo microdialysis study.
Local application of muscimol through the striatal dialysis membrane caused a significant increase in both dopamine release and dopamine metabolism in the striatum of conscious rats, however, both elevations induced by muscimol were significantly lower in the kainic acid-lesioned striatum when assessed with in vivo brain microdialysis. These findings show that intra-striatal muscimol indirectly stimulates nigrostriatal dopaminergic function by possibly causing an inhibition of striatal gamma-aminobutyric acid neurons.
Yoshida
M
M
Department of Pharmacology, Kurume University School of Medicine, Japan.
Mizoguchi
K
K
Yokoo
H
H
Tanaka
T
T
Ishii
H
H
Emoto
H
H
Koga
C
C
Tanaka
M
M
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D004594:Electrophysiology; D007267:Injections; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D017551:Microdialysis; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology*; D017072:Neostriatum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D015102:3,4-Dihydroxyphenylacetic Acid; D009118:Muscimol; D007608:Kainic Acid; D004298:Dopamine