Cardiovascular disorders in Turner's syndrome and its correlation to karyotype.
Forty-nine out of 66 patients with Turner's syndrome and different karyotypes underwent full cardiological evaluations (physical examination, electrocardiography, chest X-ray and echocardiography). Congenital cardiovascular anomalies were found in 11 patients (22.4%). Among the cardiac anomalies in patients with Turner's syndrome, aortic malformations (aortic coarctation [27%], aortic stenosis [18%] and bicuspid aortic valve [18%]) were the most frequent. We observed that the most severe malformations were found in those with karyotype 45,X or 45,X/46,XX. No anomalies were detected in patients with the X isochromosome or those mosaic with the Y component.
Hou
J W
JW
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
Hwu
W L
WL
Tsai
W Y
WY
Lee
J S
JS
Wang
T R
TR
Lue
H C
HC
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics*