The identification and quantitation of triamterene in blood and urine from a fatal aircraft accident victim.
Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base-extraction procedures, and the parent drug is unsuitable for analysis using gas chromatography. In this case, a thin-layer chromatography solvent system and high-performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by high-performance liquid chromatography.
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Toxicology and Accident Research Laboratory, Federal Aviation Administration, Department of Transportation, Oklahoma City, OK 73125-5066.
Canfield
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Hordinsky
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D000060:Accidents, Aviation; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D017809:Fatal Outcome; D006801:Humans; D013056:Spectrophotometry, Ultraviolet; D014223:Triamterene / Q000097:blood* / Q000652:urine*
D014223:Triamterene