title: P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme.
authors.affiliation: Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
authors.forename: R E
authors.initials: RE
authors.lastname: Dolle
authors.forename: D
authors.initials: D
authors.lastname: Hoyer
authors.forename: C V
authors.initials: CV
authors.lastname: Prasad
authors.forename: S J
authors.initials: SJ
authors.lastname: Schmidt
authors.forename: C T
authors.initials: CT
authors.lastname: Helaszek
authors.forename: R E
authors.initials: RE
authors.lastname: Miller
authors.forename: M A
authors.initials: MA
authors.lastname: Ator
mesh_terms: D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D020170:Caspase 1; D002401:Cathepsin B / Q000037:antagonists & inhibitors; D002460:Cell Line; D002723:Chlorobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data
chemical_list: D002723:Chlorobenzoates; C086205:N-benzyloxycarbonyl-3-amino-5-carboxy-2-oxopent-1-yl 2,6-dichlorobenzoate; D001224:Aspartic Acid; D002401:Cathepsin B; D020170:Caspase 1; D008666:Metalloendopeptidases