title: Gamma-aminobutyric acidA receptor subunits in the mediation of selective drug action.
abstract: Pharmacologic and biochemical data indicate a variety of gamma-aminobutyric acidA receptor subtypes. The identification of gamma-aminobutyric acidA receptor subunits and their isoforms has yielded a more refined characterization of the pharmacologic selectivity of these sites. Such structural diversity may explain the different responses noted with drugs acting through gamma-aminobutyric acidA receptors and makes possible the design of new agents capable of selectively manipulating this neurotransmitter system.
authors.affiliation: University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics, Kansas City 66160-7700.
authors.forename: S J
authors.initials: SJ
authors.lastname: Enna
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D006801:Humans; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
chemical_list: D014151:Anti-Anxiety Agents; D002492:Central Nervous System Depressants; D011963:Receptors, GABA-A; D001569:Benzodiazepines