title: Borderline nuclear abnormality in cervical smears: a cytological review of 200 cases with histological correlation.
abstract: The cervical cytology and histology specimens from 200 patients referred to colposcopy with borderline nuclear abnormality were reviewed. Human papillomavirus (HPV)-associated changes were identified in 103 of 200 (53%) referral smears and in 139 of 150 (91%) biopsy specimens. Cervical intraepithelial neoplasia (CIN) was less frequently diagnosed on review compared with the original histopathology reports (30.7% vs 45.4%); the discrepancy was largely attributable to a lower incidence of CINI. There was agreement in the grading of borderline nuclear abnormality in 161 of 200 referral smears following review. Twenty-three smears were upgraded to mild dyskaryosis, whereas 16 were reclassified as negative.
authors.affiliation: Department of Cytology, Royal Infirmary, Glasgow, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Stewart
authors.forename: D
authors.initials: D
authors.lastname: Livingstone
authors.forename: A F
authors.initials: AF
authors.lastname: Mutch
mesh_terms: D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000473:pathology; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology