Dietary modulation of alcohol-induced pancreatic injury.
This is a review of current progress in studies of alcohol-induced pancreatic injury using the rat intragastric ethanol infusion model. This model has been shown to reproduce the histopathologic characteristics of human ethanol-related pancreatic disease in a rodent model. A high fat liquid diet infused with ethanol potentiated the histologic and cellular effects of ethanol on the exocrine pancreas when compared to a low fat diet-ethanol infusion. Hypogranulation and apoptosis of pancreatic acinar cells are proposed as precursor lesions induced by ethanol leading to the subsequent development of acinar atrophy. A reduction in acinar cell sensitivity and responsiveness to cholecystokinin (CCK) is documented and proposed as a mechanism for the development of regressive changes through a reduction in the trophic effect of CCK.
Horne
W I
WI
Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109-1998.
Tsukamoto
H
H
D000818:Animals; D004032:Diet; D000431:Ethanol; D010179:Pancreas / Q000473:pathology / Q000503:physiopathology; D010182:Pancreatic Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D000431:Ethanol