title: Myocardial lactate release during prolonged exercise under hypoxaemia.
abstract: The possible appearance of myocardial lactate production during exercise under hypoxaemia, simulating an altitude of about 4500 metres above sea-level (masl) was investigated. Twelve healthy men were studied, after coronary sinus catheterization, during prolonged exercise breathing 12% O2 compared with men breathing air. Coronary sinus blood flow was measured by thermodilution. Exercise duration under each breathing condition was 30 min and the order normoxaemia/hypoxaemia was varied between subjects so as to compensate for any influence of a preceding exercise period on a subsequent one. Work load was adjusted so as to produce a heart rate (HR) of 130-140 beats min-1 during both hypoxaemia and normoxaemia. [14C]lactate was infused at a constant rate i.v. throughout the study to detect a possible myocardial lactate release simultaneously with a net uptake. Myocardial O2 uptake did not differ significantly between hypoxaemia and normoxaemia. The compensation for reduced blood oxygen content was achieved entirely by a greater coronary blood flow. Yet, the arterial-coronary sinus (a-cs) lactate difference was lower during hypoxaemia than normoxaemia and isotope data indicated that this was caused by a myocardial lactate release of approximately 90 mumol min-1 which was at hand during hypoxaemia but not normoxaemia, whether hypoxaemic exercise preceded or succeeded normoxaemic exercise. In conclusion, A 27% reduction in arterial oxygen saturation is almost compensated for by an increased coronary blood flow. However, during hypoxaemic exercise cardiac energy demand is to a smaller part, about 1%, covered by anaerobic metabolism.
authors.affiliation: Karolinska Institute, Department of Clinical Physiology, Huddinge Hospital, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Kaijser
authors.forename: J
authors.initials: J
authors.lastname: Grubbström
authors.forename: B
authors.initials: B
authors.lastname: Berglund
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D013997:Time Factors
chemical_list: D007773:Lactates; D019344:Lactic Acid; D010100:Oxygen