[Hemostatic factors of endothelial origin in major vascular pathology].
There is an altered hemostatic balance in vascular-based diseases. The aim of this study was to compare a group (no. = 38) of vascular patients (aortic aneurysm, carotid obstructions arteriopathies of lower limbs) and a control group (no. = 40) and assess variations in the following endothelial factors: tPA, PAI1, vWf, fibronectin and dimer D, in differentiated degrees according to the type of pathology. These were the indicative signs of endothelial mobilization resulting in the renewed continuity of the stratum with the formation of a hemostatic plug. vWf was found to be particularly significant as a marker of an ongoing atheromasic process and its extension to various vascular districts.
Bianciardi
P
P
Istituto Chirurgia Generale e Cardiovascolare, IRCCS Ospedale Policlinico, Università degli Studi di Milano.
Giordanengo
G
G
Bortolani
E M
EM
Rampoldi
V
V
Rignano
A
A
Marenghi
M C
MC
La Penna
A
A
Giorgetti
P L
PL
D000328:Adult; D000368:Aged; D001014:Aortic Aneurysm / Q000097:blood* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000503:physiopathology; D016893:Carotid Stenosis / Q000097:blood* / Q000503:physiopathology; D016228:Endothelial Growth Factors / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014652:Vascular Diseases / Q000097:blood* / Q000503:physiopathology; D014841:von Willebrand Factor / Q000378:metabolism
D016228:Endothelial Growth Factors; D005353:Fibronectins; D014841:von Willebrand Factor; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator
Fattori emostatici di origine endoteliale in patologia vascolare maggiore.