The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related T-cell dysfunction.
Differences in the in vivo and in vitro responses of T lymphocytes from chimpanzees and human subjects were compared for evidence of HIV-1 related T-cell dysfunction. There was no increased level of programmed cell death (PCD) in HIV-1 infected chimpanzees in contrast to asymptomatic individuals. Anergy could be induced with HIV-1 gp120 in human but not chimpanzee TH lymphocytes, however in vitro infection of chimpanzee TH cultures with HIV-1 resulted in complete lysis of cells within three weeks. These findings suggest that the resistance of HIV-1 infected chimpanzees to progression to AIDS is due to their relative resistance to the systemic effects of HIV-1 on T-cell dysfunction.
Heeney
J
J
Laboratory of Viral Pathogenesis, TNO-Rijswijk, The Netherlands.
Jonker
R
R
Koornstra
W
W
Dubbes
R
R
Niphuis
H
H
Di Rienzo
A M
AM
Gougeon
M L
ML
Montagnier
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000276:immunology*; D000818:Animals; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003588:Cytopathogenic Effect, Viral; D004195:Disease Models, Animal; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D007108:Immune Tolerance; D066298:In Vitro Techniques; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D015699:HIV Envelope Protein gp120