Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences.
Simple-sequence tandem repeat sequences in the 3' UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25-p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.
Jacob
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Syntex Research R7-201, Palo Alto, California 94304.
Mykytyn
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Varcony
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Drabkin
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D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D017124:Conserved Sequence; D004274:DNA, Recombinant; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D015847:Interleukin-4 / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid
D004274:DNA, Recombinant; D005819:Genetic Markers; D011971:Receptors, Immunologic; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5; D015847:Interleukin-4