[The effect of fenazepam and phenobarbital on the course of pregnancy in rats and on the early postnatal development of their progeny].
Examining the effects of phenazepam and phenobarbital on the course of pregnancy and the development of offsprings has revealed that phenobarbital that has an embryotoxic effect reduced the number of rat offsprings and diminished their weight, but failed to affect the behavioral responses of newborn rats. On the contrary, phenazepam had no embryotoxic effect, but on entering the newborn rats' organism with milk it inhibited some behavioral reactions in the early postnatal period.
Chobanov
N G
NG
Voronina
T A
TA
Liubimov
B I
BI
Smol'nikova
N M
NM
Nemova
E P
EP
D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology* / Q000633:toxicity; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D010634:Phenobarbital / Q000494:pharmacology* / Q000633:toxicity; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D010634:Phenobarbital
Vliianie fenazepama i fenobarbitala na techenie beremennosti krys i rannee postnatal'noe razvitie ikh potomstva.