[Gold salt-induced pneumonia and CD4 alveolitis].
In a 62-year old man who consulted for dyspnoea, clinical, radiological and functional examinations led to the diagnosis of immunoallergic lung disease caused by gold salt therapy. Regression of the symptoms when gold salt therapy was withdrawn supported this diagnosis. Contrary to previously published cases concerning treatment with gold salts, the study of bronchoalveolar lavage (BAL) fluid yielded a lymphocytic alveolitis with a very high CD4/CD8 ratio, as already reported with methotrexate, cyclothiazide and nitrofurantoin. This case can be added to the list of drugs that may induce CD4 alveolitis; it also reminds the existence of gold salt pneumonia and permits to discuss the value of a lymphocyte subpopulation study in the BAL fluid in patients with drug-induced immunoallergic lung diseases.
Breton
J L
JL
Service de Pneumologie, Centre Hospitalier, Belfort.
Westeel
V
V
Garnier
G
G
Louis
J M
JM
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D015496:CD4-Positive T-Lymphocytes; D006801:Humans; D008297:Male; D008875:Middle Aged; D050607:Organogold Compounds; D011014:Pneumonia / Q000139:chemically induced*; D012129:Respiratory Function Tests
D018501:Antirheumatic Agents; D050607:Organogold Compounds
Pneumopathie médicamenteuse aux sels d'or et alvéolite à CD4.