title: Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction.
abstract: Using papaverine, papaverine/phentolamine, or prostaglandin E1 (PGE1), intracavernosal pharmacotherapy has been successful in treating erectile dysfunction. The limiting factor of using these medicines is intracorporeal fibrosis with the first two and a high cost with PGE1. Our experience with intracavernosal therapy in patients with impotence secondary to neurogenic disease has included 35 men, 30 of whom are spinal cord injured, 3 after radical prostatectomy, 1 with multiple sclerosis, and 1 with lower extremity weakness after surgery. Patients ranged in age from 22 to 59 years, with an average of 36.3 years; mean follow-up was 13.8 months. Intracavernosal therapy has been performed with a tri-mixture of papaverine hydrochloride (smooth muscle relaxant), phentolamine mesylate (alpha-adrenergic blocking agent) and alprostadil (PGE1- a vasodilator and smooth muscle relaxant). Of the patient population, all 35 patients were able to have adequate erections for sexual relations with minimal complications. Acting synergistically, the ingredients promote erectile activity using small doses and without a significant incidence of priapism or fibrosis. Techniques of injection, dosing and followup are discussed.
authors.affiliation: Department of Urology and Spinal Cord Injury, Veterans Administration Medical Center, Seattle, WA.
authors.forename: R
authors.initials: R
authors.lastname: Chao
authors.forename: D E
authors.initials: DE
authors.lastname: Clowers
mesh_terms: D000328:Adult; D000527:Alprostadil / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D004338:Drug Combinations; D016527:Drug Costs; D016903:Drug Monitoring; D004357:Drug Synergism; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005355:Fibrosis; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D010208:Papaverine / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D017060:Patient Satisfaction; D010409:Penile Diseases / Q000139:chemically induced / Q000473:pathology; D010410:Penile Erection / Q000187:drug effects*; D010646:Phentolamine / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D011317:Priapism / Q000139:chemically induced; D011468:Prostatectomy / Q000009:adverse effects*; D013119:Spinal Cord Injuries / Q000150:complications*
chemical_list: D004338:Drug Combinations; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine