Lack of effect on the low density lipoprotein receptor in hamsters treated with 17 alpha-ethinyl estradiol.
High pharmacological doses of 17 alpha-ethinyl estradiol are known to increase the number of low density lipoproteins (LDL)-receptors in rats and rabbits, leading to a profound decrease in plasma cholesterol levels. Here, using rats as a positive control, we demonstrate that in hamsters ethinyl estradiol does not upregulate liver LDL-receptors, nor change plasma LDL turnover or plasma LDL-cholesterol. The lack of effect in estradiol-treated hamsters suggests that the hormonal control is different from that in rats.
Himber
J
J
Department of Cardiovascular Diseases, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Missano
B
B
Kuhl
H
H
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D051381:Rats; D011973:Receptors, LDL / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D014280:Triglycerides; D004997:Ethinyl Estradiol; D002784:Cholesterol