Beta-cyclodextrin as a direct compression excipient compared to conventional ones.
Beta-Cyclodextrin was evaluated as a direct compression excipient and compared to conventional excipients. The measured physical properties included particle size and particle size distribution, flowability, bulk density, and hygroscopicity. Compression characteristics were evaluated by measuring compactibility, compression force-hardness profiles and compression force requirements. The materials studied were directly compressed into tablets and the produced tablets were evaluated with regard to uniformity of weight, disintegration time, crushing strength and friability. The results suggest that beta-cyclodextrin is a good candidate as a direct compression excipient.
Saleh
S I
SI
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt.
D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000737:chemistry*; D004339:Drug Compounding; D005079:Excipients; D006244:Hardness; D013607:Tablets; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D005079:Excipients; D013607:Tablets; D047392:beta-Cyclodextrins; C031215:betadex