title: [5-fluorouracil in goniotrepanation with poor prognosis. Results of 1-year follow-up].
abstract: 14 eyes of 14 patients with medically untreatable glaucoma and extremely bad surgical prognosis because of young age, secondary glaucomas or following previous surgery were treated by means of goniotrephination with a scleral flap and a fornix-based conjunctival flap. Postoperatively, all eyes received 5 mg 5-fluorouracil in 0.5 ml NaCl 0.9% subconjunctivally daily for 7 days and weekly for another 6 weeks. IOP was lowered in all eyes from 33.9 +/- 5.0 mmHg preoperatively to 15.6 +/- 8.4 mmHg 1 year postoperatively. 71% of eyes were IOP controlled without further therapy. Results were unfavourable in eyes with irido-corneo-endothelial syndrome. Local side effects were less frequent than described previously, possible due to the reduced but prolonged administration of 5-fluorouracil. Also, all eyes received corneal supportive therapy with hyaluronic acid and polyvinyl alcohol.
authors.affiliation: Universitäts-Augenklinik Mainz.
authors.forename: N
authors.initials: N
authors.lastname: Pfeiffer
authors.forename: F
authors.initials: F
authors.lastname: Grehn
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014130:Trabeculectomy; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology
chemical_list: D005472:Fluorouracil
vernacular_title: 5-Fluorouracil bei Goniotrepanationen mit schlechter Prognose. 1-Jahres-Ergebnisse.