title: Periventricular nucleus lesioning modulates specific somatostatin binding in various brain regions and anterior pituitary.
abstract: The effects of periventricular nucleus (Pe) lesioning on the plasma growth hormone (GH) levels and the anterior pituitary (A.P.) and brain somatostatin (SRIF) receptors were studied. A transient significant increase in plasma GH level in lesioned rats was detected 1 day after the operation. This elevated level of plasma GH started to decrease 3 days after lesioning. These changes were paralleled by an increase in binding of 125I-Tyr11-SRIF-14 to the A.P. 1 day after lesioning. This result could further confirm that the SRIF inhibitory action on GH release takes place at the A.P. level. Also, a transient increase in binding of the radioligand was detected in some brain areas 1 and 4 days after the lesion. However, the mechanism by which this increase takes place remains to be elucidated.
authors.affiliation: Zoology Department, Faculty of Science, Alexandria University, Egypt.
authors.forename: I
authors.initials: I
authors.lastname: Sabry
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Kakegawa
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004558:Electric Stimulation; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism* / Q000473:pathology; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013004:Somatostatin / Q000097:blood / Q000378:metabolism*
chemical_list: D017481:Receptors, Somatostatin; D013004:Somatostatin