[Detection of risk factors for hemodynamic dysadaptation under physical loading by data of genetic studies (the beta-adrenoreceptor blockade test) (Part 3)].
Examinations in 28 pairs of twins who were studied by bicycle ergometry during a "pure" graded exercise and an exercise during oral administration of anapriline have shown that the functional features of the heart make some contribution to cardiovascular implementation of the "pure" graded exercise. When given exercise and anapriline, energy processes play a role in its implementation. It is suggested that exercise + anapriline will cause substantial metabolic changes which can be essential in cardiac decompensation if exercise is not limited in the use of beta-blockers.
Sokolov
E I
EI
Pereponov
Iu P
IuP
Belova
E V
EV
Zaev
A P
AP
Petrin
S V
SV
D000222:Adaptation, Physiological / Q000187:drug effects / Q000235:genetics*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects / Q000235:genetics; D006439:Hemodynamics / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D011433:Propranolol; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Vyiavlenie faktorov riska gemodinamicheskoĭ disadaptatsii pri fizicheskoĭ nagruzke po dannym geneticheskikh issledovaniĭ (proba s blokadoĭ beta-adrenoretseptorov) (soobshchenie 3).