Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment.
The induction of lupus-like syndromes with the appearance of single-stranded DNA antibodies is a well-known complication of drug therapy. In this report we present a patient with an erosive seropositive rheumatoid arthritis developing the clinical and serological features of systemic lupus erythematosus including the occurrence of double-stranded DNA antibodies under sulfasalazine treatment.
Wildhagen
K
K
Abt. Immunologie, Medizinische Hochschule Hannover, Germany.
Hartung
K
K
Hammer
M
M
Mau
W
W
Schmidt
R E
RE
Deicher
H
H
Zeidler
H
H
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D012460:Sulfasalazine / Q000627:therapeutic use*
D000974:Antibodies, Antinuclear; D012460:Sulfasalazine; D004247:DNA