Seasonal variations of nasal resistance in allergic rhinitis and environmental pollen counts. II: Efficacy of preseasonal therapy.
We gave Mao-bushi-saishin-to, a Chinese blended medicine, and azelastine to an adult patient with hay fever due to Japanese cedar pollen and measured nasal resistance and ambient floating pollen counts throughout the time of Japanese cedar pollination in separated years. In the patient Mao-bushi-saishin-to was effective against preseasonal increases in nasal airway resistance but could not control severe episodes of allergic rhinitis caused by high dose exposure to Japanese cedar pollen and also perhaps caused by a priming effect. Azelastine inhibited both pre- and post-seasonal increases in nasal airway resistance but not only on high pollen counts days.
Naito
K
K
Department of Otolaryngology, Fujita Health University School of Medicine, Aichi, Japan.
Ishihara
M
M
Senoh
Y
Y
Takeda
N
N
Yokoyama
N
N
Iwata
S
S
D000328:Adult; D000403:Airway Resistance; D003131:Combined Modality Therapy; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D008516:Medicine, Chinese Traditional; D009296:Nasal Cavity / Q000187:drug effects* / Q000503:physiopathology; D009668:Nose Diseases / Q000188:drug therapy / Q000503:physiopathology; D010793:Phthalazines / Q000627:therapeutic use*; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D006634:Histamine H1 Antagonists; D010793:Phthalazines