title: [The effect of amiridin and tacrine on the potassium currents in a nerve fiber].
abstract: The experiments on isolated nerve fibers from the frog Rana ridibunda have demonstrated that aminoacridine tacrin and aminocholine amiridine given in a concentration of 1 microM induced a 3-4 mV increase in the resting potential of the intact Ranvier nodal membrane depolarized by several millivolts by external source current, accompanied by a rise in the amplitude and curvature of action potential. With the voltage clamp, the two agents shifted a steady state potassium conductivity vs. the voltage curve measured in the vicinity of the resting potential in isotonic KCl solution. The shift had a hyperpolarizing direction and magnitude of 1-2 mV at the agents' concentrations of 0.01-0.1 microM and 10 mV at concentrations higher than 1 microM. The resting potential change calculated on the basis of conductivity measurements was in agreement with that observed experimentally. It is suggested that the tacrin- and amiridine-induced shift of the voltage sensitivity region of potassium channels near the resting potential might underlie their therapeutic effects in patients with senile dementia of the Alzheimer type.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Burov
authors.forename: E M
authors.initials: EM
authors.lastname: Peganov
authors.forename: L M
authors.initials: LM
authors.lastname: Shapovalova
mesh_terms: D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011895:Rana ridibunda; D000077331:Ringer's Solution; D013619:Tacrine / Q000494:pharmacology*
chemical_list: D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D007552:Isotonic Solutions; D015221:Potassium Channels; D011619:Psychotropic Drugs; D013619:Tacrine; D000077331:Ringer's Solution; C049860:amiridine
vernacular_title: Vliianie amiridina i takrina na kalievye toki v nervnom volokne.