title: Cerebrospinal fluid-intracranial volume ratio measurements in patients with HIV infection: CLASS image analysis technique.
abstract: OBJECTIVE
  To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease.
  
  
  METHODS
  A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients.
  
  
  RESULTS
  The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03).
  
  
  CONCLUSIONS
  No substantial change in CSF/ICV occurs until development of late-stage AIDS.
authors.affiliation: Department of Neurology, University College London Medical School and Middlesex Hospital, England.
authors.forename: M N
authors.initials: MN
authors.lastname: Paley
authors.forename: W K
authors.initials: WK
authors.lastname: Chong
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: J K
authors.initials: JK
authors.lastname: Shepherd
authors.forename: A M
authors.initials: AM
authors.lastname: Clews
authors.forename: B J
authors.initials: BJ
authors.lastname: Sweeney
authors.forename: M A
authors.initials: MA
authors.lastname: Hall-Craggs
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: S P
authors.initials: SP
authors.lastname: Newman
authors.forename: M J
authors.initials: MJ
authors.lastname: Harrison
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000453:epidemiology; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006716:Homosexuality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008961:Models, Structural; D011446:Prospective Studies; D012307:Risk Factors