[P53 in atherosclerotic plaques].
The methylation and expression of P53 were studied in atherosclerotic plaques. Atherosclerosis was initiated in 2.5-3.0 kg New Zealand white Rabbits by feeding cholesterol, oil and endothelial debridement of the aorta. There were the methylation of the partial CCGG sites, low levels of expression of the wild-type P53 and mutant P53 protein in the plaques. These might be an important cause of the cellular proliferation during development of atherosclerosis.
Yang
H P
HP
Cardiovascular Institute, Beijing Medical University.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000235:genetics* / Q000473:pathology; D015870:Gene Expression; D016158:Genes, p53; D017403:In Situ Hybridization; D008297:Male; D008745:Methylation; D017354:Point Mutation; D011817:Rabbits; D017422:Sequence Analysis, DNA; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D016159:Tumor Suppressor Protein p53