Inhaled nitric oxide in patients with normal and increased pulmonary vascular resistance after cardiac surgery.
We studied the haemodynamic effects of inhaled nitric oxide 40 p.p.m. in two groups of patients after cardiac surgery (mitral valve surgery or coronary artery bypass grafting). Nitric oxide caused a significant reduction in pulmonary vascular resistance after mitral valve surgery in patients who had pre-existing pulmonary hypertension, but no change in haemodynamic state in the coronary artery bypass group of patients, who had normal pulmonary arterial pressures.
Snow
D J
DJ
Department of Anaesthesia, Papworth Hospital, Cambridge.
Gray
S J
SJ
Ghosh
S
S
Foubert
L
L
Oduro
A
A
Higenbottam
T W
TW
Wells
F C
FC
Latimer
R D
RD
D000280:Administration, Inhalation; D001026:Coronary Artery Bypass; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D008943:Mitral Valve / Q000601:surgery; D009569:Nitric Oxide / Q000494:pharmacology*; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects*
D009569:Nitric Oxide