Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.
The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.
Kondo
M
M
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
Takeshita
T
T
Higuchi
M
M
Nakamura
M
M
Sudo
T
T
Nishikawa
S
S
Sugamura
K
K
D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D008040:Genetic Linkage; D015851:Interleukin-7 / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018123:Receptors, Interleukin / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D020395:Receptors, Interleukin-7; D016511:Severe Combined Immunodeficiency / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014960:X Chromosome
D000911:Antibodies, Monoclonal; D015851:Interleukin-7; D018123:Receptors, Interleukin; D015375:Receptors, Interleukin-2; D020395:Receptors, Interleukin-7