Frequency of RAS and p53 mutations in acute promyelocytic leukemias.
The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.
Longo
L
L
Istituto Clinica Medica I, University of Perugia, Italy.
Trecca
D
D
Biondi
A
A
Lo Coco
F
F
Grignani
F
F
Maiolo
A T
AT
Pelicci
P G
PG
Neri
A
A
D001483:Base Sequence; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000209:etiology / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation