[The blood coagulation system under overdoses of the copolymer of 1-vinyl-3-methylimidazole iodide with the diethyl ether of maleic acid demonstrating antiheparin activity].
The effects of the active heparin antagonist--1-vinyl-3-methylimidazolium iodide-maleic acid diethyl ether copolymer--on the blood coagulative system were investigated. The effect of polycation was shown to appear only when the therapeutical dose was significantly increased and to manifest itself in the development of hypocoagulation. Hypocoagulative changes occurred only by inhibiting the activity of clotting factors V and VIII. Also, there was a moderate reduction in platelet counts.
Afanas'eva
G V
GV
Smirnov
A I
AI
Efimov
V S
VS
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000633:toxicity; D007093:Imidazoles / Q000494:pharmacology* / Q000633:toxicity; D008298:Maleates / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors
D006494:Heparin Antagonists; D007093:Imidazoles; D008298:Maleates; C073477:1-vinyl-3-methylimidazole-maleic acid diethyl ester copolymer
Issledovanie sistemy svertyvaniia krovi v usloviiakh peredozirovok sopolimera 1-vinil-3-metilimidazoliia ĭodida s diétilovym éfirom maleinovoĭ kisloty, proiavliaiushchego antigeparinovuiu aktivnost'.