title: Hemodynamic, hemorheologic, and hemocoagulative changes after treatment with picotamide in patients affected by peripheral arterial disease (PAD) of the lower limbs.
abstract: Effects of picotamide on platelet activity and on some hemorheologic, coagulative, and hemodynamic parameters were investigated in a randomized, double-blind, placebo-controlled study for eighteen months. Twenty patients, average age 61.5 +/- 9.6 (SD) years, with peripheral arterial disease (PAD) at functional stage 2 of the Fontaine classification and with intermittent claudication for at least six months were studied. Ten patients received tablets of picotamide, 300 mg three times a day, and 10 subjects received three identical placebo tablets each day. Similar atherosclerotic disease risk factors were present in both groups. Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmographic wave.
authors.affiliation: Institute of Geriatric Medicine and Surgery, University of Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Neirotti
authors.forename: M
authors.initials: M
authors.lastname: Molaschi
authors.forename: M
authors.initials: M
authors.lastname: Ponzetto
authors.forename: C
authors.initials: C
authors.lastname: Macchione
authors.forename: L
authors.initials: L
authors.lastname: Poli
authors.forename: F
authors.initials: F
authors.lastname: Bonino
authors.forename: F
authors.initials: F
authors.lastname: Fabris
mesh_terms: D001157:Arterial Occlusive Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001777:Blood Coagulation / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D004311:Double-Blind Method; D004907:Erythrocyte Deformability / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D018056:Hemorheology; D006801:Humans; D007383:Intermittent Claudication / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D017156:Photoplethysmography; D010795:Phthalic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D010795:Phthalic Acids; D010975:Platelet Aggregation Inhibitors; D001620:beta-Thromboglobulin; C011581:picotamide; D005340:Fibrinogen