[Prevention of toxicity of cyclosporine A on rat pancreatic islet beta-cells by Ligustrazine].
The toxic effect of cyclosporine A (CsA) on pancreatic islet beta-cells and the preventive effect of ligustrazine (LIG) on CsA-associated beta-cell toxicity in SD rats were investigated. The oral administration of CsA 50 mg/kg/day for ten days caused hyperglycaemia and lowering of plasma and pancreatic insulin levels that were prevented and/or minimized by the combined intra-peritoneal administration of LIG 50 mg/kg/day. An increase of urinary thromboxane B2 (TXB2) and urinary TXB2/6-keto-prostaglandin F1 alpha (6-k-PGF1 alpha) ratio in CsA-treated rats could also be prevented and/or minimized by the administration of LIG. The results suggested that the preventive effect of LIG on CsA-associated islet beta-cell toxicity was relevant to the improvement of prostacyclin-thromboxane A2 imbalance.
Gu
M J
MJ
Dept. of Endocrinology, Changzheng Hospital, Shanghai.
Liu
Z M
ZM
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000818:Animals; D016572:Cyclosporine / Q000633:toxicity*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013929:Thromboxane B2 / Q000652:urine
D005343:Fibrinolytic Agents; D011719:Pyrazines; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D016572:Cyclosporine; C017953:tetramethylpyrazine