Antitussive effect of oxatomide on citric acid-induced cough in conscious guinea pig. Preliminary communication.
Oxatomide (CAS 60607-34-3), a diphenylmethyl-piperazine benzimidazole derivative is a new oral antiallergic drug useful in asthma in preventing allergic attacks. Using the model of citric acid-induced coughing in the unanesthetized, unrestrained guinea pig the antitussive effect of oxatomide was investigated. The animals were treated with logarithmically increasing doses of oxatomide (0.5, 1, 2 mg/kg, suspended in 0.5 ml of polyethylene glycol 200 + 0.5 ml of saline) and with the vehicle alone administered intraperitoneally (1 ml) 45 min before the challenge. Oxatomide reduced the number of coughs during the 3 min of challenge, lengthened the time of onset and reduced the number of coughs after cessation of the challenge significantly and a linear dose-effect regression was observed.
Braga
P C
PC
Center for Respiratory Pharmacology, School of Medicine, University of Milan, Italy.
Bossi
R
R
Piatti
G
G
Dal Sasso
M
M
D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002951:Citrates; D019343:Citric Acid; D003371:Cough / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D012044:Regression Analysis
D000996:Antitussive Agents; D002951:Citrates; D006634:Histamine H1 Antagonists; D010879:Piperazines; D019343:Citric Acid; C015408:oxatomide