title: Spontaneous altered hepatocellular foci (AHF) in captive aged male cotton rats (Sigmodon hispidus).
abstract: Spontaneous altered hepatocellular foci (AHF) of basophilic type were observed in adult male cotton rats. The histological features of these foci were similar to those observed in Fischer 344 rats. However, an immunohistochemical technique with antibody to glutathione S-transferase placental form (GST-P) failed to stain these foci. Also normal bile ducts were not immunoreactive for GST-P. The presence of a gall bladder and of non-GST-P immunoreactive liver foci and bile ducts suggests that these cotton rats are phylogenetically closer to mice than rats.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
authors.forename: M G
authors.initials: MG
authors.lastname: Paranjpe
authors.forename: C W
authors.initials: CW
authors.lastname: Qualls
authors.forename: A M
authors.initials: AM
authors.lastname: Chandra
authors.forename: R L
authors.initials: RL
authors.lastname: Lochmiller
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D005982:Glutathione Transferase / Q000032:analysis; D008113:Liver Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D016205:Sigmodontinae
chemical_list: D005982:Glutathione Transferase