Insulin-secretional effect of exogenic amino acids in rabbits.
D,L-arginine and L-lysine, introduced into the alimentary canal (IAC), caused significant secretion of insulin in rabbits, whereas D,L-methionine or L-phenylalanine evoked only a small effect. Also, intravenous (IV) injection of D,L-arginine caused dose dependent and biphasic insulin output. On the other hand, L-phenylalanine given IV decreased both basal and glucose--stimulated insulin level in blood.
Maćkowiak
P
P
Department of Animal Physiology and Biochemistry, Academy of Agriculture, Poznań, Poland.
Nogowski
L
L
Nowak
K W
KW
D000284:Administration, Oral; D000601:Amino Acids, Essential / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008239:Lysine / Q000494:pharmacology; D008297:Male; D008715:Methionine / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology; D011817:Rabbits
D000601:Amino Acids, Essential; D001786:Blood Glucose; D007328:Insulin; D010649:Phenylalanine; D001120:Arginine; D008715:Methionine; D005947:Glucose; D008239:Lysine