[Genetic hypertension in the rat is partially dependent of parathyroid glands. Results of a crossed transplantation trial].
The parathyroid hypertensive factor (PHF) is present in the plasma of SHR rats. The authors of this study set out to determine whether this factor was also present in the Lyon (LH male and female) and Milan (MHS male) hypertensive rats. Five week old normotensive rats (LN and MNS) were transplanted with the parathyroid glands of LH and MHS rats immediately after parathyroidectomy (PTX). Plasma calcium fell rapidly after PTX but returned to physiological levels, confirming the functional activity of the graft. Systolic blood pressures of transplanted rats were significantly higher than normotensive LN and MNS controls. These results confirm the role of the parathyroid glands in the genesis of hypertension in Lyon and Milan male and female rats. They suggest that PHF may be implicated in the hypertensive mechanisms of these two models of genetic hypertension.
Pernot
F
F
Faculté de pharmacie, pharmacologie moléculaire et cellulaire, CNRS URA 600, université Louis-Pasteur, Strasbourg.
Burkard
C
C
Vincent
M
M
Ferrari
P
P
Sassard
J
J
Gairard
A
A
D000818:Animals; D001685:Biological Factors / Q000097:blood / Q000502:physiology*; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D010280:Parathyroid Glands / Q000637:transplantation; D016105:Parathyroidectomy / Q000009:adverse effects*; D051381:Rats; D011918:Rats, Inbred SHR
D001685:Biological Factors; C064505:parathyroid hypertensive factor; D002118:Calcium
L'hypertension artérielle génétique chez le rat est partiellement dépendante des glandes parathyroïdes. Résultats d'une expérience de transplantation croisée.