title: A single center's experience with 308 free flaps for repair of head and neck cancer defects.
abstract: Since its inception at our institution in 1988, microvascular reconstructive surgery has become an integral part of the treatment of head and neck cancer patients. This review of 308 free flaps performed over the last 4 years was done to evaluate the complication and flap loss rates and to investigate which factors may contribute to these rates. The overall complication rate was 36.1 percent, the vessel thrombosis rate was 6.8 percent, the flap loss rate was 5.5 percent, and the flap salvage rate was 19.0 percent. Multifactorial analysis of delayed reconstruction, tobacco use, alcohol consumption, previous radiation therapy, previous surgery, and use of vein grafts showed that only previous surgery and the use of vein grafts led to significantly higher rates of flap loss (p < 0.01 for both).
authors.affiliation: Department of Reconstructive and Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston.
authors.forename: M A
authors.initials: MA
authors.lastname: Schusterman
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
authors.forename: G P
authors.initials: GP
authors.lastname: Reece
authors.forename: S S
authors.initials: SS
authors.lastname: Kroll
authors.forename: M
authors.initials: M
authors.lastname: Marchi
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006085:Graft Survival; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D013524:Surgical Flaps / Q000009:adverse effects / Q000145:classification / Q000379:methods*; D015996:Survival Rate; D013927:Thrombosis / Q000209:etiology; D014680:Veins / Q000637:transplantation