[Enterosorbent with immobilized trimethylaminoethanol chloride. I. Hypolipidemic properties].
Hypolipidemic properties of the synthesized enterosorbent, water soluble polymer containing covalently immobilized trimethylamine ethanol chloride, were studied. Content of cholesterol in blood was decreased by 29% and accumulation of cholesterol in liver tissue--by 22% after oral administration of the enterosorbent at a dose of 250 mg/kg into rats with hypercholesterolemia. Cholestyramine exhibited the similar effect only at a dose of 2.5 g/kg. Except for the hypocholesterolemic effect, the enterosorbent altered also the lipoprotein spectrum in rat blood serum.
Lopukhin
Iu M
IuM
Andrianova
I P
IP
Ryzhenkov
V E
VE
Samoĭlova
N A
NA
Chistiakova
A M
AM
Frolova
Iu V
IuV
Iamskov
I A
IA
Sergienko
V I
VI
Lapuk
Ia I
IaI
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D016061:Enterosorption / Q000379:methods*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats
D000960:Hypolipidemic Agents; D000644:Quaternary Ammonium Compounds; D002784:Cholesterol
Enterosorbent s immobilizovannym khloridom trimetilaminoétanola. I. gipolipidemicheskie svoĭstva.