Local tolerance of a new ciclopirox olamine vaginal preparation in rats and rabbits.
A new ciclopirox olamine vaginal preparation was tested for toxicity after topical vaginal administration for 28 days to rats and rabbits. At the end of the experiments animals were sacrificed for autopsy, the main organs were weighed, hematological, coagulative and biochemical parameters were checked and histological examinations were performed on uterus and vagina. The results demonstrated the good topical and systemic tolerance of this new vaginal formulation in rats and rabbits.
Manzardo
S
S
Pharmacological and Toxicological Department, Poli Industria Chimica, Rozzano, Milan, Italy.
Pinzetta
A
A
Coppi
G
G
D000282:Administration, Intravaginal; D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D000077768:Ciclopirox; D004361:Drug Tolerance; D005260:Female; D009929:Organ Size / Q000187:drug effects; D011728:Pyridones / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox