title: Persistence of type-specific human papillomavirus infection among cytologically normal women.
abstract: Determinants of genital human papillomavirus (HPV) persistence in 393 women initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged > or = 30 years had a higher percentage of persistence (65%) than those < or = 24 years (32%, P = .02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = .11). These findings were independent of each other and of timing between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection.
authors.affiliation: Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: A
authors.initials: A
authors.lastname: Hildesheim
authors.forename: M H
authors.initials: MH
authors.lastname: Schiffman
authors.forename: P E
authors.initials: PE
authors.lastname: Gravitt
authors.forename: A G
authors.initials: AG
authors.lastname: Glass
authors.forename: C E
authors.initials: CE
authors.lastname: Greer
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: D R
authors.initials: DR
authors.lastname: Scott
authors.forename: B B
authors.initials: BB
authors.lastname: Rush
authors.forename: P
authors.initials: P
authors.lastname: Lawler
authors.forename: M E
authors.initials: ME
authors.lastname: Sherman
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001483:Base Sequence; D002584:Cervix Uteri / Q000821:virology; D017931:DNA Primers / Q000737:chemistry; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes / Q000737:chemistry; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D013997:Time Factors; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*
chemical_list: D017931:DNA Primers; D015344:DNA Probes, HPV; D015345:Oligonucleotide Probes