The effect of chronic ingestion of ethanol on modulation of granulomatous inflammation in experimental schistosomiasis in mice.
We studied the role of ethanol on the modulation of liver granulomata around Schistosoma mansoni eggs in mice. Albino mice, receiving 7% ethanol as the sole drinking liquid, at 60 and 90 days post-infection, presented smaller granulomata than controls did, when sacrificed at 120 days post-infection. No differences in diameters could be observed, when ethanol was given 4 months before up to 120 days after infection. The results suggested that modulation of schistosome granulomata by ethanol ingestion varies with time and duration of drug consumption.
Castro
L P
LP
Departamento de Anatomia Patológica e Medicina Legal, Faculdade de Medicina da UFMG, Belo Horizonte.
Bambirra
E A
EA
Coelho
P M
PM
Silva
M E
ME
D000818:Animals; D004334:Drug Administration Schedule; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006099:Granuloma / Q000469:parasitology / Q000473:pathology*; D008109:Liver Diseases, Parasitic / Q000473:pathology*; D051379:Mice; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000473:pathology*
D000431:Ethanol