Translocation 4;13 with adjacent 1 and 3-1 segregations leading to complementary segmental trisomies 13.
A familial 4;13 translocation showed three different segregations and two kinds of imbalances: two brothers had a distal trisomy 13 [46,XY,-4,+der 4, t(4;13)(q35;q14)mat] and their maternal uncle had a proximal trisomy 13 [47, XY,+der13,t(4;13)(q35;q14)mat]. A relative excess of abortions was observed in this family, probably related to a lethal variety of segregation.
Barros-Nuñez
P
P
Division de Genética, Instituto Mexicano de Seguridad Social, Guadalajara Jal, Mexico.
Higareda
O
O
Cantu
J M
JM
D000328:Adult; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D002894:Chromosomes, Human, Pair 4; D005190:Family; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D010641:Phenotype; D014178:Translocation, Genetic; D014314:Trisomy