title: Chronological loss of bone zinc during dietary zinc deprivation in neonatal pigs.
abstract: This research was conducted to measure the chronological changes in zinc concentrations of biopsied bone, hair, and plasma samples collected weekly during dietary zinc deprivation. Pigs 1-2 wk of age were fed a basal diet (< 1 microgram Zn/g) during a 1-wk depletion period and then assigned to one of three dietary regimens for 4 wk: a low-zinc diet (4 micrograms Zn/g) fed ad libitum, an adequate-zinc diet (100 micrograms/g) fed ad libitum, and an adequate-zinc diet restricted in intake to allow eight gain comparable with that of the low-zinc group. Bone zinc remained at approximately 120 micrograms/g dry wt for the control groups fed adequate zinc but steadily declined in pigs fed the low-zinc diet, leveling off at approximately 25% of the control values. Plasma and hair zinc concentrations also decreased but at a more rapid rate. Bone zinc is mobilizable in neonatal pigs, and biopsied bone zinc concentration is a reliable index of zinc status.
authors.affiliation: Department of Animal Sciences, University of Missouri, Columbia 65211.
authors.forename: D J
authors.initials: DJ
authors.lastname: Bobilya
authors.forename: G L
authors.initials: GL
authors.lastname: Johanning
authors.forename: T L
authors.initials: TL
authors.lastname: Veum
authors.forename: B L
authors.initials: BL
authors.lastname: O'Dell
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D001846:Bone Development / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D006197:Hair / Q000737:chemistry; D008297:Male; D013552:Swine; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism*
chemical_list: D015032:Zinc