Organ changes after intravenous trinonanoin administration in rabbits.
For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.
Linseisen
J
J
Institute of Nutrition Science, Technical University of Munich, FRG.
Wolfram
G
G
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects*; D000818:Animals; D002149:Energy Intake; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010289:Parenteral Nutrition, Total; D011817:Rabbits; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*
D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D014280:Triglycerides; C031461:tripelargonin; C008776:pelargonic acid