Animal models in experimental atherosclerosis: a critical review.
The most important features of lipoprotein metabolism are demonstrated and receptor-mediated endocytosis is emphasized. The different lipoprotein makeup of different animal species and humans is shown. The role of fibre, protein and polyunsaturated fatty acids in diet-induced hypercholesterolaemia is evaluated. The criteria of choosing the appropriate animal model for atherosclerosis research are discussed.
Fekete
S
S
Department of Animal Nutrition, University of Veterinary Science, Budapest, Hungary.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D004032:Diet / Q000009:adverse effects; D004043:Dietary Fiber; D004195:Disease Models, Animal; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013552:Swine
D004043:Dietary Fiber; D008074:Lipoproteins