The progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one reduces K(+)-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: a semiquantitative immunocytochemical study.
5 alpha-Pregnan-3 alpha ol-20-one (3 alpha-OH-DHP) reduced the depolarization-induced loss of GABA and, to a lesser extent, the glutamate-like immunoreactivities from nerve terminals in the in vitro hippocampal slice. Phenobarbital (PB) had similar effects. These results suggest that 3 alpha-OH-DHP affects presynaptic transmitter release, possibly in a barbiturate-like manner.
Taubøll
E
E
Department of Neurology, Rikshospitalet, National Hospital, University of Oslo, Norway.
Ottersen
O P
OP
Gjerstad
L
L
D000818:Animals; D005260:Female; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D009411:Nerve Endings / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D011280:Pregnanolone / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D018698:Glutamic Acid; D011374:Progesterone; D005680:gamma-Aminobutyric Acid; D011280:Pregnanolone; D011188:Potassium