[In vitro inhibition effect of tamoxifen on three cervical cancer cell lines].
The effect of tamoxifen, an antiestrogenic drug, on the growth of three squamous cervical cancer cell lines in serum-free medium was studied, using the breast cancer cell line MCF-7 as a tamoxifen-sensitive control. It was found that low concentration revealed growth inhibition effect and high concentration revealed cytotoxicity effect in the four cancer cell lines. Their sensitivity was different with respective thresholds. Breast cancer cell line MCF-7 had the lowest threshold of growth inhibition, whereas cervical cancer cell line HX151c had the lowest threshold of cytotoxicity.
Qiu
L X
LX
Jiangxi Provincial Women and Children Health Hospital, Nanchang.
Li
C X
CX
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D013629:Tamoxifen