title: The incidence of acute arthritis in stroke patients, and its impact on rehabilitation.
abstract: To investigate the occurrence of acute arthritis after stroke, we prospectively studied 111 patients presenting with their first stroke and no history of previous arthritis. Clinical, biochemical and serological assessment was complemented by brain CT scan; appropriate X-rays were taken of any inflamed joints and synovial fluid was collected and analysed. Those with aseptic arthritis were randomly chosen to receive either intra-articular steroids or non-steroidal anti-inflammatory drugs (NSAIDs). Patients with significant renal impairment were excluded. Acute arthritis was observed within 8.34 (median) days, on the paretic side in 19 patients (10 crystal, 4 inflammatory osteoarthritis, 1 septic, 4 unexplained) and on the non-paretic side in 4 patients (1 inflammatory osteoarthritis, 1 septic, 2 unexplained). One patient had pseudogout affecting both sides. Thiazide therapy prior to the stroke was associated with gout in 3 patients. Hospital patients with arthritis had a longer median length of stay than those without (41 vs. 21 days: p = 0.01). Patients receiving intra-articular steroids recovered more rapidly than those treated with NSAIDs (p < 0.05). This prospective study demonstrates the occurrence of acute arthritis in paretic limbs after stroke. Physicians should be aware of this complication, and that administration of intra-articular steroids in aseptic cases speeds rehabilitation and recovery.
authors.affiliation: Oxford Regional Rheumatic Diseases Research Centre, Stroke Mandeville Hospital, Aylesbury, UK.
authors.forename: K
authors.initials: K
authors.lastname: Chakravarty
authors.forename: C J
authors.initials: CJ
authors.lastname: Durkin
authors.forename: A H
authors.initials: AH
authors.lastname: al-Hillawi
authors.forename: R
authors.initials: R
authors.lastname: Bodley
authors.forename: M
authors.initials: M
authors.lastname: Webley
mesh_terms: D000208:Acute Disease; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000150:complications / Q000453:epidemiology* / Q000534:rehabilitation; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000534:rehabilitation; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal