[Clinical strategy of chronic obstructive pulmonary disease in the elderly].
Chronic obstructive pulmonary disease (COPD) is a disease involving either or both of chronic bronchitis and emphysema. In the elderly, bronchial asthma is usually called chronic asthma because of sustained asthma attacks and resistance to therapy. Although the absolute value of IgE is low in the asthma in the elderly, IgE values correlated to the symptoms of asthma in the elderly. Therefore, asthma in the elderly is supposed to be primarily caused by allergic reactions. Airway epithelium products histamine methyl-transferase (HMT) and cholinesterase. Allergic reactions and/or virus infection in the airway epithelium reduce productions of these enzymes, which exacerbate bronchoconstriction. Steroid hormones increase these enzymes and relieve bronchoconstriction. Silent aspiration may exacerbate asthma attack in the night and recurrent cough and sputum in COPD. Macrolide antibiotics relieve chronic infections in the elderly. Plural constriction against bullae using thoracoscopy reduce dyspnea dramatically in emphysema.
Sasaki
H
H
Department of Geriatric Medicine, Tohoku University School of Medicine.
Sekizawa
K
K
D000368:Aged; D001249:Asthma / Q000276:immunology; D001991:Bronchitis / Q000276:immunology; D005260:Female; D006637:Histamine N-Methyltransferase / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008173:Lung Diseases, Obstructive / Q000175:diagnosis* / Q000276:immunology; D008297:Male
D007073:Immunoglobulin E; D006637:Histamine N-Methyltransferase