Pharmacokinetic study of bisaramil in man.
Six healthy volunteers received an oral dose of 100 mg and an intravenous dose of 35 mg of bisaramil in a cross over study. Plasma concentrations were measured by HPLC. Bisaramil was eliminated from the plasma with a half life of 8.6 +/- 1.8 h and 9.0 +/- 4.1 h after iv. and oral administration, respectively. The mean total plasma clearance and volume of distribution were found to be 70 +/- 13.1 l/h and 864 +/- 204 l, respectively. The calculated oral bioavailability of bisaramil in tablets amounted to 56 +/- 20%.
Gémesi
L
L
Chemical Works of Gedeon Richter Ltd., Budapest.
Kapás
M
M
Matos
L
L
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D001643:Bridged Bicyclo Compounds / Q000097:blood / Q000493:pharmacokinetics*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002722:Chlorobenzenes; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D000889:Anti-Arrhythmia Agents; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002722:Chlorobenzenes; C045644:bisaramil