[Synaptonemal complexes of chromosomes of male mice after prolonged administration of neoaquasept].
A long-term (during 4 months) daily peroral injections of neoaquasept (NA) (a drinking water disinfections agent) at a dose corresponding to the normal level of consumption increases the number of spermatocytes in which the sexual bivalent associates with normal autosomal bivalents (up to 18.2%). In single cells a premature desynapsis of sex chromosomes at late pachytene was observed. There was the appearance of single cells with the X0 karyotype. A 3-fold excess of the normal consumption of NA causes an increase in the number of cells with the above disturbance in the SC structure and behaviour and causes the appearance of heteromorphic bivalents. On the 7th day after a single MTD injection of NA male mice displayed a sharp (up to 27.9%) increase in the number of cells in which the sexual bivalent associated with autosomal bivalents, formation of univalents of autosomal and sex chromosomes, SC degeneration.
Kolomiets
O L
OL
Mazurova
T F
TF
Bogdanov
Iu F
IuF
Bogush
T A
TA
Mal'tsev
M V
MV
D000293:Adolescent; D000328:Adult; D000818:Animals; D002875:Chromosomes / Q000187:drug effects* / Q000648:ultrastructure; D004202:Disinfectants / Q000494:pharmacology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D011418:Prophase / Q000187:drug effects*; D012730:Sex Chromosomes / Q000187:drug effects / Q000648:ultrastructure; D013090:Spermatocytes / Q000187:drug effects / Q000648:ultrastructure; D013573:Synaptonemal Complex / Q000187:drug effects*; D014227:Triazines / Q000494:pharmacology*
D004202:Disinfectants; D014227:Triazines; C011765:troclosene
Issledovanie sinaptonemnykh kompleksov khromosom samtsov mysheĭ posle dlitel'nogo vvedeniia neoakvasepta.