title: Comparison of human and canine external femoral morphologies in the context of total hip replacement.
abstract: The canine is frequently used as a model for human hip arthroplasty research. In order to better understand the appropriateness of the canine as a model for human total hip replacement studies, the external morphology of canine and human femurs were examined and compared. Several differences were found between canine and human femora, including angular measurements, anterior bow, and femoral head position relative to the femoral diaphysis. In addition, the human femur was noted to undergo age-related changes in several of the measured parameters. The canine femur did not exhibit any age-related changes in the measured parameters. This study suggests that there are limitations to the use of the canine model in human hip arthroplasty research, and that discretion must be exercised when attempting to extrapolate results from a canine study to the human clinical condition.
authors.affiliation: Bone and Joint Research Laboratories, V.A. Medical Center, Salt Lake City, Utah 84148.
authors.forename: R D
authors.initials: RD
authors.lastname: Bloebaum
authors.forename: D T
authors.initials: DT
authors.lastname: Ota
authors.forename: J G
authors.initials: JG
authors.lastname: Skedros
authors.forename: J P
authors.initials: JP
authors.lastname: Mantas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D004285:Dogs; D005260:Female; D005269:Femur / Q000033:anatomy & histology*; D005270:Femur Head / Q000033:anatomy & histology; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013045:Species Specificity