Strategies in immunotherapy of insulin-dependent diabetes mellitus.
Complete and definitive prevention of diabetes obtained in animal models by using a number of diversified maneuvers has elicited major hope for immunoprevention of the disease in man. Therapeutic trials of immunosuppressive drugs in human IDDM have opened the way towards prevention or cure of the disease. Difficulties encountered, including requirement for chronic immunosuppression and risk of metabolic relapses, suggest two complementary approaches: precocious intervention based on early and reliable disease prediction, and tolerance-inducing regimens, hopefully using shorter and innocuous therapy. Animal data suggest that this is indeed an achievable goal.
Bach
J F
JF
Hopital Necker, Immunologie Clinique, Paris, France.
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D051379:Mice; D016688:Mice, Inbred NOD
D007166:Immunosuppressive Agents