Capacity of the retinogeniculate pathway to reorganize following ablation of visual cortical areas in developing and mature cats.
The purpose of the present study was to determine the pattern and density of retinal projections to the dorsal lateral geniculate nucleus (dLGN) following ablation of visual cortical areas in developing cats of different postnatal ages and in mature cats. The terminations of retinal projections to the dLGN were evaluated following the injection of tritiated amino acids into one eye. Regardless of age, a visual cortical ablation of areas 17 and 18 induces massive death of neurons within the regions of the dLGN that are linked topographically to the cortical areas removed. However, the pattern of retinal projections to these degenerated regions of the dLGN differs depending upon whether the cortical lesion is incurred early in postnatal life or in adulthood. Following ablation on the day of birth (P1), virtually all surviving cells were found in the C-complex of dLGN with only a token number in the A-laminae. Correspondingly, retinal projections were maintained to the C-complex of the nucleus and were barely detectable in the degenerated A-laminae. However, in cats in which areas 17 and 18 had been removed in adulthood (> or = 6 months of age) retinal projections were maintained to the A-laminae even though nearly all neurons in those laminae had degenerated. Moreover, a subgroup of animals that incurred area 17 and 18 ablations at P1 showed that the modification of retinal projections to the A-laminae occurs within the first postnatal month, and an additional subgroup showed that retinal projections become increasingly resistant to the degenerative events in the dLGN that follow ablation of areas 17 and 18 at progressively older ages during the first postnatal month. Furthermore, retinal inputs also respond, in an age-dependent way, to degeneration of neurons in the C-complex induced by extension of the cortical ablation to include extrastriate visual areas.
Lomber
S G
SG
Department of Anatomy and Neurobiology, Boston University School of Medicine, Massachusetts 02118.
Payne
B R
BR
Cornwell
P
P
Pearson
H E
HE
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D001931:Brain Mapping; D002415:Cats / Q000254:growth & development / Q000502:physiology*; D005829:Geniculate Bodies / Q000254:growth & development / Q000502:physiology*; D009416:Nerve Regeneration; D009473:Neuronal Plasticity; D012160:Retina / Q000254:growth & development / Q000502:physiology*; D012183:Retrograde Degeneration; D013045:Species Specificity; D014793:Visual Cortex / Q000293:injuries*; D014795:Visual Pathways / Q000254:growth & development / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*