[The evaluation of 1-hydroxypyrene as a bioindicator of industrial exposure to polycyclic aromatic hydrocarbons].
One hundred and twenty-two workers (16 from a coke production plant, 106 from a graphite electrode manufacturing plant) agreed to participate in this study designed to evaluate the relationship between the exposure to polycyclic aromatic hydrocarbons (PAHS) and the urinary excretion of 1-hydroxypyrene (1-HOP), the main metabolite of pyrene. The results show that the concentration of pyrene in air is highly correlated with total PAHS amount (r = 0.083, p < 0.001), with a the correlation coefficient between 1-HOP and total PAHS of r = 0.72 (p < 0.001). The biological half life of the 1-HOP was determined (18 hrs) and the non interference of smoking habits in relation to 1-HOP urinary was established, concluding that 1-HOP is a suitable bioindicator of the occupational exposure to PAHS.
Mercado-Calderón
F
F
Unidad de Toxicología Industrial, Hospital Central Norte, Petróleos Mexicanos.
D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D015415:Biomarkers / Q000652:urine; D003077:Coke; D006108:Graphite; D006207:Half-Life; D006801:Humans; D008800:Mexico; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011083:Polycyclic Compounds / Q000009:adverse effects* / Q000032:analysis; D011721:Pyrenes / Q000032:analysis* / Q000493:pharmacokinetics; D012907:Smoking / Q000652:urine; D013861:Thiocyanates / Q000652:urine
D000395:Air Pollutants, Occupational; D015415:Biomarkers; D003077:Coke; D011083:Polycyclic Compounds; D011721:Pyrenes; D013861:Thiocyanates; D006108:Graphite; C033146:1-hydroxypyrene; C031760:thiocyanate
Evaluación del 1-hidroxipireno como bioindicador de la exposición industrial a los hidrocarburos aromáticos policíclicos.