Increased soluble ICAM-1 in tracheal aspirates of infants with bronchopulmonary dysplasia.
Raised concentrations of soluble intracellular adhesion molecule 1 (sICAM-1) in tracheal aspirates from premature infants may predict development of bronchopulmonary dysplasia (BPD). We measured sICAM-1 in tracheal aspirates and serum samples from 15 newborn babies (9 with BPD, 6 without BPD) at 2-4, 6-7, and 12-14 days of age. sICAM-1 concentrations in tracheal aspirates were significantly raised at 6-7 and 12-14 days of age in infants who later developed BPD compared with infants who did not develop BPD. Serum samples from the two groups did not differ significantly in sICAM-1. Raised sICAM-1 in tracheal aspirate was a good predictor of lung injury in infants who later developed BPD.
Kojima
T
T
Department of Paediatrics, Kansai Medical University, Osaka, Japan.
Sasai
M
M
Kobayashi
Y
Y
D015703:Antigens, CD / Q000032:analysis* / Q000737:chemistry; D001424:Bacterial Infections / Q000378:metabolism; D001997:Bronchopulmonary Dysplasia / Q000097:blood / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000737:chemistry; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018799:Intercellular Adhesion Molecule-1; D007442:Intubation, Intratracheal; D008297:Male; D011014:Pneumonia / Q000097:blood / Q000378:metabolism; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000378:metabolism; D012189:Retrospective Studies; D012995:Solubility; D013396:Suction; D014132:Trachea / Q000737:chemistry*
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1