Reduction of collagen degradation in experimental granulation tissue by vitamin E and selenium.
The importance of antioxidants in inflammatory tissues has been studied in vivo. Degradation of homologous 3H-collagen powder by experimental granulation tissue induced by cellulose sponges in the rat was monitored as the radioactivity excreted in urine. By administering pharmacological doses of both vitamin E and selenium subcutaneously and by injection into sponges implanted subcutaneously, this breakdown of collagen was reduced. Injections in the sponges also arrested the maturation of the granulation tissue. Vitamin E and selenium are potential inhibitors of the free oxygen radicals from phagocytic inflammatory cells. It is therefore suggested that these radicals may play a rôle in the collagen destruction by granulation tissues, as in periodontitis.
Asman
B
B
Department of Periodontology, Karolinska Institute, Huddinge University Hospital, Sweden.
Wijkander
P
P
Hjerpe
A
A
D000818:Animals; D003094:Collagen / Q000187:drug effects* / Q000378:metabolism* / Q000652:urine; D004487:Edema / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D007279:Injections, Subcutaneous; D008297:Male; D009504:Neutrophils / Q000473:pathology; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015503:Surgical Sponges; D014316:Tritium; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D014316:Tritium; D014810:Vitamin E; D003094:Collagen; D012643:Selenium