title: [Left ventricular filling in young insulin-dependent diabetics].
abstract: Left ventricular function indices were measured by pulsed Doppler-echocardiography in 17 young patients (mean age: 25 +/- 5) with insulin-dependent diabetes and 17 controls (identical mean age: 25 +/- 5) free of heart disease. All subjects had normal left ventricular systolic function. Twenty three per cent of diabetics showed a left ventricular filling anomaly on the basis of at least two abnormal indices. Isovolumic relaxation time was significantly prolonged in diabetics as compared with normal individuals (83 +/- 7 v. 68 +/- 9 ms, p < 0.00015). Half-pressure time was also prolonged in the patients (46 +/- 9 v. 38 +/- 6 ms, p < 0.01), the same applying to rapid filling deceleration time (158 +/- 32 v. 136 +/- 29 ms, p < 0.05). Peak rapid filling rate, the proportion of total filling accounted for by rapid filling, peak atrial systole velocity and the atrial contribution to total filling did not differ between the diabetics and controls. Systolic blood pressure was significantly higher in diabetics as compared with controls (124 +/- 8 v. 114 +/- 10 mmHg, p = 0.007), although remaining within normal limits. This would not, however, explain the differences seen between the 2 groups regarding left ventricular profile. The filling anomalies reported here were not correlated with the duration of diabetes nor with other parameters such as glycosylated hemoglobin or 24-hour microalbuminuria. Our results suggest that approximately 20 p. cent of young diabetics have sub-clinical left ventricular anomalies.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service de Cardiologie, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre.
authors.forename: G
authors.initials: G
authors.lastname: Roul
authors.forename: P
authors.initials: P
authors.lastname: Bareiss
authors.forename: P
authors.initials: P
authors.lastname: Germain
authors.forename: J M
authors.initials: JM
authors.lastname: Mossard
authors.forename: F
authors.initials: F
authors.lastname: Grunenberger
authors.forename: J L
authors.initials: JL
authors.lastname: Schlienger
authors.forename: A
authors.initials: A
authors.lastname: Sacrez
mesh_terms: D000328:Adult; D000367:Age Factors; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging*; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D016277:Ventricular Function, Left
vernacular_title: Le remplissage ventriculaire gauche chez le diabétique insulino-dépendant jeune.