title: Bloom's syndrome cells GM1492 lack detectable p53 protein but exhibit normal G1 cell-cycle arrest after UV irradiation.
abstract: The tumor suppressor gene p53 is thought to be a key factor in the onset of G1 cell-cycle arrest following DNA damage. However, here we describe cells derived from a patient with Bloom's syndrome, lacking any detectable p53 protein, that still shows a functional G1 cell-cycle checkpoint after irradiation with UV-C. Comparison with cells from other Bloom's patients showed that the absence of p53 protein is not a specific characteristic of Bloom's syndrome.
authors.affiliation: Laboratory of Molecular Carcinogenesis, Sylvius Laboratories, Leiden University, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van Laar
authors.forename: W T
authors.initials: WT
authors.lastname: Steegenga
authors.forename: A G
authors.initials: AG
authors.lastname: Jochemsen
authors.forename: C
authors.initials: C
authors.lastname: Terleth
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Eb
mesh_terms: D001816:Bloom Syndrome / Q000378:metabolism / Q000473:pathology*; D002460:Cell Line; D016193:G1 Phase / Q000528:radiation effects; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D016159:Tumor Suppressor Protein p53