A comparison of the effect on gastric emptying of alfentanil or morphine given during anaesthesia for minor surgery.
Twenty patients, scheduled for minor gynaecological surgery, were studied. Anaesthesia was induced with propofol and maintained with oxygen, nitrous oxide and enflurane. Patients were randomly allocated to two groups: group 1 were given alfentanil 0.2 mg; group 2 were given morphine 5 mg. The rate of gastric emptying was measured indirectly by the paracetamol absorption technique. The results showed that morphine caused greater delay in gastric emptying compared with alfentanil (p < 0.05). The observed effect on gastric emptying rate may potentially affect the risk of peri-operative regurgitation and aspiration. This study provides further evidence that in short day-case procedures, when oral medication may be required postoperatively, alfentanil may be preferable to morphine as an intra-operative opioid.
Bennett
M W
MW
General Infirmary, Leeds.
Shah
M V
MV
Bembridge
J L
JL
D000082:Acetaminophen / Q000097:blood; D000328:Adult; D015760:Alfentanil / Q000494:pharmacology*; D000698:Analgesia / Q000379:methods; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D013511:Minor Surgical Procedures; D009020:Morphine / Q000494:pharmacology*; D013997:Time Factors
D015760:Alfentanil; D000082:Acetaminophen; D009020:Morphine