[Intrathecal synthesis of IgG: comparative study of its determination with 5 different equations, in 733 neurologic patients].
In order to find out the degree to which rupture of the blood-brain barrier (BBB) could influence the diagnostic effectiveness of five equations used to determine the intrathecal synthesis of IgG, a comparative study was performed with results from 733 patients with different neurological processes either related to an immune response (PNI) or not (PNNI). Rupture of the BBB was determined by a quotient of cerebrospinal fluid (CSF)/serum albumin (COA) higher than that obtained in the control group. When the BBB was retained, there was no clear superiority of one formula over another, but an altered BBB was the conditioning factor in the divergence. The extended Index was the least influenced by the rupture of the BBB, while Tourtellotte's equation was the most affected. In agreement with the clinical information data, the IgG Index was the most sensitive equation, while the extended Index was the most specific.
Enguídanos
M J
MJ
Servicio de Laboratorio Clínico, Hospital La Fe, Valencia.
Coret
F
F
Vílchez
J
J
Chermá
M D
MD
D001812:Blood-Brain Barrier; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000096:biosynthesis*; D008433:Mathematics; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000378:metabolism; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013131:Spine / Q000378:metabolism*
D007074:Immunoglobulin G
Síntesis intratecal de IgG: estudio comparativo de su evaluación mediante cinco ecuaciones diferentes, en 733 pacientes neurológicos.