title: Internal ablative sinostomy using a fiber delivered Q-switched CTE: YAG laser (2.69 microns).
abstract: Current trends of laser technology towards low-thermal photoablative pulsed mid-infrared lasers open new, more adequate approaches to experimental surgical procedures which have already been evaluated in the past. Transcorneal laser ablation of the trabecular meshwork (internal sinostomy) in human autopsy eyes was performed with a Q-switched CTE:YAG laser (wavelength: 2.69 microns, pulse width: 1 microsecond). Beam delivery was achieved with conventional optical quartz fibers (Low-hydroxy-fused-silica: 0.3 ppm, 50 cm length, 200 microns diameter). Light- and scanning-electron-microscopy were used for histological examination and micromorphological analysis. By applying two laser pulses (6 J/cm2) to the functional trabecular meshwork, a round sinostomy with a diameter corresponding to the diameter of the fiber-tip was achieved. It was possible to set several internal sinostomies into the chamber angle opposite to the entering paracentesis of the laser fiber-tip. Collateral thermal tissue alteration reached up to 50 microns, and since fiber-tip contact was maintained during laser application, thermal tissue alteration was also found around the opposite wall of Schlemm's canal. At higher energy fluences mechanical (disruptive vaporization) effects were significantly enhanced. It can be concluded, that low-thermal pulsed mid-infrared lasers are adequate instruments to perform transcorneal trabecular ablation (abinterno sinostomy). The laser used in this study (CTE:YAG) bears the advantage that its radiation can easily be delivered in conventional optical quartz fibers.
authors.affiliation: University Eye Hospital of Cologne, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Kermani
authors.forename: H
authors.initials: H
authors.lastname: Lubatschowski
authors.forename: W
authors.initials: W
authors.lastname: Ertmer
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
mesh_terms: D005336:Fiber Optic Technology; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D053685:Laser Therapy; D008855:Microscopy, Electron, Scanning; D010030:Ostomy / Q000379:methods; D014129:Trabecular Meshwork / Q000601:surgery* / Q000648:ultrastructure