Relevance of chlorine-substituent for the antifungal activity of syringomycin and syringotoxin, metabolites of the phytopathogenic bacterium Pseudomonas syringae pv. syringae.
Structural analogues of syringomycin and syringotoxin were produced by fermentation, characterized by FAB-MS and amino acid analysis and compared to the parent compounds in the antibiosis test against Rhodotorula pilimanae. The C-terminal residue was shown to be important for the activity.
Grgurina
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Dipartimento di Scienze Biochimiche A. Rossi-Fanelli, Università La Sapienza di Roma, Italy.
Barca
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Cervigni
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Gallo
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Scaloni
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Pucci
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D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000737:chemistry / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic; D011549:Pseudomonas / Q000187:drug effects* / Q000472:pathogenicity; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D010456:Peptides, Cyclic; C032677:syringomycin; C069036:syringotoxin B