Systemic absorption and systemic effects of ocularly administered dexmedetomidine in rabbits.
Dexmedetomidine is a selective alpha 2-adrenoceptor agonist which has previously been shown to reduce the ocular pressure of normotensive rabbits as well as those with pressures artificially elevated by laser irradiation. In this study instillation of an equivalent hypotensive dose (12.5 micrograms) did not cause changes in heart rate, blood pressure, blood glucose or plasma catecholamine content even though dexmedetomidine could be detected in plasma. However, this dose given intravenously (i.v.) was also without effect. Higher ocular doses resulted in equivalent bradycardia and changes in blood glucose levels as when the dose was given i.v. These two parameters proved to be most sensitive indicators of systemic alpha 2-agonism, blood pressure did not change and plasma catecholamine levels were too low to be reliably assayed. It is concluded that when hypotensive doses of dexmedetomidine are instilled into the eye, intraocular concentrations are sufficiently high to exert pharmacological effects. As it is absorbed into the general circulation, it is diluted such that its systemic effects are minimal.
MacDonald
E
E
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
Vartiainen
J
J
Jäsberg
K
K
Vuorilehto
L
L
Salonen
J S
JS
Urtti
A
A
D000042:Absorption; D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood; D005123:Eye / Q000378:metabolism*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D020926:Medetomidine; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011817:Rabbits
D000316:Adrenergic alpha-Agonists; D001786:Blood Glucose; D002395:Catecholamines; D007093:Imidazoles; D009883:Ophthalmic Solutions; D020926:Medetomidine