Selective differentiation of CD4+ T helper cell subsets.
During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4 T helper cell subsets. These have been driven, in part, by the realization that signals (cytokines) from the innate immune response are critical in T cell subset differentiation. In addition, several studies have also elucidated how the antigen-presenting cell, the antigenic epitope and the antigen concentration may contribute to the selective development of a particular T helper cell subset.
Scott
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School of Veterinary Medicine, University of Pennsylvania, Philadelphia.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007239:Infections / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D016513:Mice, SCID / Q000276:immunology; D008822:Mice, Transgenic; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction
D016207:Cytokines; D011948:Receptors, Antigen, T-Cell