title: The determination of anabolic steroids by MECC, gradient HPLC, and capillary GC.
abstract: Methodologies are presented for the qualitative and quantitative determinations of anabolic steroids in forensic exhibits using micellar electrokinetic capillary chromatography (MECC), high performance liquid chromatography (HPLC) and capillary gas chromatography (GC). Analyses of representative pharmaceutical dosage forms (including a commercial aqueous suspension, a commercial tablet, several commercial oil samples and various simulated dosage units) were performed using a simple, one step quantitative extraction procedure with methanol. Good agreement was obtained between all three techniques. Retention, migration and linearity data are presented and compared for over twenty anabolic steroids commonly encountered in forensic exhibits. A principal component analysis study confirmed the orthogonality of the three techniques.
authors.affiliation: Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, VA.
authors.forename: I S
authors.initials: IS
authors.lastname: Lurie
authors.forename: A R
authors.initials: AR
authors.lastname: Sperling
authors.forename: R P
authors.initials: RP
authors.lastname: Meyers
mesh_terms: D045930:Anabolic Agents / Q000032:analysis*; D002845:Chromatography / Q000379:methods*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D005554:Forensic Medicine / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D045930:Anabolic Agents