title: Method for detection of picornavirus capsid binders with soluble intercellular adhesion molecule 1.
abstract: A method utilizing immobilized major group rhinoviruses and biotinylated soluble intercellular adhesion molecule 1 has been developed for the detection of capsid binders. Binding measurements indicate a loss in relative affinity of biotinylated soluble intercellular adhesion molecule 1 for rhinoviruses by capsid binders. This method and a new class of capsid binders are discussed.
authors.affiliation: Department of Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877.
authors.forename: K
authors.initials: K
authors.lastname: Last-Barney
authors.forename: S D
authors.initials: SD
authors.lastname: Marlin
authors.forename: K
authors.initials: K
authors.lastname: Pal
authors.forename: C
authors.initials: C
authors.lastname: Cahill-Feehan
authors.forename: E J
authors.initials: EJ
authors.lastname: McNally
authors.forename: D D
authors.initials: DD
authors.lastname: Jeanfavre
authors.forename: V J
authors.initials: VJ
authors.lastname: Merluzzi
mesh_terms: D001710:Biotin / Q000378:metabolism; D002213:Capsid / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006367:HeLa Cells; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D010849:Picornaviridae / Q000378:metabolism*; D012229:Rhinovirus / Q000378:metabolism*; D012995:Solubility; D013844:Thiazoles / Q000032:analysis* / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D013844:Thiazoles; D018799:Intercellular Adhesion Molecule-1; D001710:Biotin