title: Scirrhous adenocarcinoma of the rectum in a cow.
abstract: Clinical and pathological examinations were performed on a 3-year-old Holstein-Friesian cow with scirrhous adenocarcinoma of the rectum. Hemorrhagic diarrhea causing rectal stenosis was a principal clinical manifestation. Microscopically, cancerous transformation of the intestinal epithelium was observed in the rectal crypts. Irregular glandular arrangements containing PAS positive and eosinophilic mucus were observed in the lumen, which were surrounded by scirrhous collagenous fibers. The neoplastic epithelial cell had round or ovoid nucleus and slightly eosinophilic cytoplasm. Metastatic lesions were localized in the marginal and medullary sinuses of the anorectal lymph nodes.
authors.affiliation: Veterinary Clinic and Training Center, Miyagi Prefectural Federation of Agricultural Mutual-Aid Association, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D003967:Diarrhea / Q000209:etiology / Q000662:veterinary; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000662:veterinary; D007413:Intestinal Mucosa / Q000473:pathology; D008207:Lymphatic Metastasis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*