Glycosylated hemoglobins in pregnant women with normal and abnormal glucose tolerance.
Glycosylated hemoglobin (HbA1) levels were compared in low risk pregnant Singaporean women with normal and abnormal glucose response. HbA1 (mean +/- 1 SD) levels in normal and abnormal groups (489 and 72, respectively) were 4.65 +/- 0.49 and 4.85 +/- 0.50, respectively. While mean levels were significantly different, there was a considerable overlap of levels in both groups. At various gestation periods, mean HbA1 levels between normal and abnormal groups showed significant difference only at late gestation. The latter may have contributed to significant differences in HbA1 levels between normal and abnormal groups as a whole. The considerable overlap of HbA1 values in normal and abnormal groups indicate that HbA1 may be insensitive as a screening method for glucose intolerance.
Loke
D F
DF
Department of Obstetrics and Gynecology, National University of Singapore, National University Hospital.
Chua
S
S
Kek
L P
LP
Thai
A C
AC
Ratnam
S S
SS
D015415:Biomarkers / Q000032:analysis; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008403:Mass Screening; D011247:Pregnancy / Q000097:blood*
D015415:Biomarkers; D006442:Glycated Hemoglobin