Occurrence of craniosynostosis in neonates exposed to cocaine and tobacco in utero.
The occurrence of craniosynostosis (premature closure of cranial sutures) has been reported to be 3 to 5 per 10,000 live births. The incidence is even lower among African-American infants. The District of Columbia General Hospital serves primarily the African-American population with approximately 2000 deliveries a year. In the last 10 years, three neonates with craniosynostosis have been born at DC General Hospital; all three infants were African Americans. These infants were exposed to cocaine and tobacco in utero, which suggests a possible association between intrauterine cocaine and tobacco exposure and premature closure of cranial sutures. Possible pathogenesis of craniosynostosis in association with cocaine and tobacco use is discussed.
Beeram
M R
MR
Department of Pediatrics, District of Columbia General Hospital, Washington 20003.
Abedin
M
M
Shoroye
A
A
Jayam-Trouth
A
A
Young
M
M
Reid
Y
Y
D000328:Adult; D003042:Cocaine / Q000633:toxicity*; D003398:Craniosynostoses / Q000209:etiology*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D019966:Substance-Related Disorders; D014029:Tobacco Use Disorder
D003042:Cocaine