[Evolution of resistance to antibiotics and antiseptics of hospital Staphylococcus aureus strains isolated from 1980 to 1991].
From 1980 to 1991, 925 non epidemic hospital isolates of S. aureus were selected and phage typed. MIC of 20 antibiotics and 4 antiseptics were determined by agar dilution method. The proportion of isolates susceptible to all antibiotics remains constant; however the trend to the resistance is strong during the study period (oxacillin 10-->20%, erythromycin 17-->28%, pefloxacin 4-->19%...). Strains resistant to oxacillin become more and more multiple resistant; some of recent isolates are resistant to 7 antibiotic families. There are very few products active against these strains i.e, glycopeptides (100%), pristinamycin (96%), fusidic acid (94%). This finding implies the need for continuous surveillance at the local and national level.
Reverdy
M E
ME
Centre National de Référence des Staphylocoques, Faculté de Médecine Alexis Carrel, Lyon, France.
Bes
M
M
Brun
Y
Y
Fleurette
J
J
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D006757:Hospital Units; D006801:Humans; D066298:In Vitro Techniques; D018942:Macrolides; D010068:Oxacillin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology*; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001548:Benzalkonium Compounds; D018942:Macrolides; D013754:Tetracyclines; D010068:Oxacillin
Evolution de la résistance aux antibiotiques et aux antiseptiques de souches hospitalières de Staphylococcus aureus isolées de 1980 à 1991.