title: An 18-month vitreous fluorophotometric follow-up study in juvenile diabetics.
abstract: The authors assessed a fluorophotometry follow-up study of 18 months in 24 juvenile insulin-dependent diabetic patients with no retinopathy. The initial duration of diabetes was 5.96 +/- 3.44 years and the glycosylated hemoglobin (HbA1c) was 10.12 +/- 2.27%. The baseline Vitreous Penetration Ratio transmittance value (VPRt) was 4.13 +/- 1.31 x 10-6 min-1 and after 18 months was 5.36 +/- 1.85 x 10-6 min-1, yielding a statistically significant difference (p < 0.01). The average HbA1c during the follow-up term was 9.80 +/- 1.72%. VPRt values were significantly correlated with the duration of diabetes and HbA1c. During the follow-up 3 patients developed foveal background diabetic retinopathy with respect to a high initial VPRt value (6.22 +/- 0.27 x 10-6 min-1), nevertheless, the other 7 patients with high baseline VPRt did not do so. We suggest that vitreous fluorophotometry could be a beneficial procedure in the management of insulin-dependent diabetic patients; however, there is not a cut-off value for VPRt values to help distinguish patients prone to develop retinopathy.
authors.affiliation: Department of Ophthalmology, Hospital Universitario San Carlos, Universidad Complutense de Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Benitez del Castillo
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: J
authors.initials: J
authors.lastname: Garcia Sanchez
authors.forename: J L
authors.initials: JL
authors.lastname: Ruibal
authors.forename: F
authors.initials: F
authors.lastname: Reverte
authors.forename: J M
authors.initials: JM
authors.lastname: Ibarra
mesh_terms: D000293:Adolescent; D001813:Blood-Retinal Barrier / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D015590:Fluorophotometry; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D019793:Fluorescein; D005452:Fluoresceins; D006442:Glycated Hemoglobin