title: Fluconazole: pharmacokinetics and indications.
abstract: Fluconazole is a new systemic azole antifungal agent, with the imidazole group substituted by a triazole, presenting a decrease in lipophilicity, soluble in water, weakly bound to plasma proteins, and a wide range of formulations. The time to reach steady-state with a once daily dosage is approximately 7 days. Distribution of fluconazole is extensive and even throughout the tissues, and the drug circulates as a free drug. Half-life elimination is approximately 30 h. Indications are given for fungal infections in AIDS patients and mycoses.
authors.affiliation: Escuela de Ciencias Médicas, Universidad Autónoma de Centro América (UCA), San José, Costa Rica.
authors.forename: F
authors.initials: F
authors.lastname: Montero-Gei
mesh_terms: D000818:Animals; D015725:Fluconazole / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy*
chemical_list: D015725:Fluconazole