Effects of intraaccumbens dopamine agonist SK&F38393 and antagonist SCH23390 on locomotor activities in rats.
The present study examined the effects of the dopamine D1 and D5 subtype receptors agonist, R(+)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol (SK&F38393), and antagonist, R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-ben zaz epine (SCH23390), on locomotor activities after bilateral microinjection into the nucleus accumbens (Acb). SK&F38393 (0.1-10.0 micrograms) significantly potentiated and SCH23390 (0.01-1.0 microgram) significantly attenuated locomotor activity as measured by horizontal distance in cm. The data were supportive of the hypothesis that dose-related locomotor activities induced by microinjections of SK&F38393 into the Acb are independently mediated by D1 and D5 subtype receptors.
Meyer
M E
ME
Department of Psychology, University of Florida, Gainesville 32611.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D015259:Dopamine Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats
D001552:Benzazepines; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D004298:Dopamine