title: The effect of phospholipase A2 on mitochondrial glycerol-3-phosphate oxidation.
abstract: Glycerol-3-phosphate oxidation in brown adipose tissue mitochondria of cold-adapted hamster is strongly inhibited by phospholipase A2 (PLA2). Our data show that the glycerol-3-phosphate branch of the respiratory chain is sensitive to PLA2 action more than the succinate branch and that the transfer of reducing equivalents from the glycerol-3-phosphate dehydrogenase to artificial electron acceptor is especially sensitive to the PLA2 action.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
authors.forename: H
authors.initials: H
authors.lastname: Rauchová
authors.forename: M
authors.initials: M
authors.lastname: Kalous
authors.forename: Z
authors.initials: Z
authors.lastname: Drahota
mesh_terms: D000818:Animals; D006224:Cricetinae; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D005994:Glycerophosphates / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D008928:Mitochondria / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D012710:Serum Albumin, Bovine / Q000494:pharmacology
chemical_list: D005230:Fatty Acids, Nonesterified; D005994:Glycerophosphates; D012710:Serum Albumin, Bovine; C029620:alpha-glycerophosphoric acid; D005993:Glycerolphosphate Dehydrogenase; D010741:Phospholipases A; D054467:Phospholipases A2