title: Association of antihypertensive agents and blood lipids in a population-based survey.
abstract: Clinical trials indicate that many antihypertensive medications alter blood lipids. These lipid changes may be of sufficient magnitude to influence subsequent coronary heart disease rates. We examined this association in a large population sample (N = 15,918, ages 25-74, 12% on antihypertensive medication) surveyed cross-sectionally from 1980 to 1986. Subjects taking antihypertensive medication had a mean serum total cholesterol 4.0 mg per dl higher than those not taking these medications after we adjusted for age, sex, weight, smoking, alcohol, blood pressure, and exercise. High-density lipoprotein cholesterol was lower in the medicated group by 2.5 mg per dl. There was no evidence that the length of medication use was related to lipid levels.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.
authors.forename: D
authors.initials: D
authors.lastname: Strickland
authors.forename: J M
authors.initials: JM
authors.lastname: Sprafka
authors.forename: R V
authors.initials: RV
authors.lastname: Luepker
authors.forename: R H
authors.initials: RH
authors.lastname: Grimm
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D011159:Population Surveillance
chemical_list: D000959:Antihypertensive Agents; D008076:Cholesterol, HDL; D002784:Cholesterol