[Gonadal dysfunctions in liver cirrhosis].
Testicular atrophy, loss of libido and feminization are observed in patients with nonalcoholic liver cirrhosis, Serum total and free testosterone levels are decreased in patients with advanced liver cirrhosis and is normal in compensated cirrhotic patients. In compensated liver cirrhosis, sex hormone binding globulin is increased, and is related with increasing serum total testosterone. Serum total and free estradiol levels and ratio of estradiol to testosterone are increased in cirrhotic patients. Hyperestrogenization is related with female physical characteristics. Gonadal dysfunctions observed in cirrhotic patients are primary in the gonadal failure, then a concomitant with pituitary defect occurs. These abnormalities in liver cirrhosis are reversible.
Morimoto
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D000328:Adult; D004700:Endocrine System Diseases / Q000209:etiology; D004958:Estradiol / Q000097:blood; D005262:Feminization / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013733:Testicular Diseases / Q000209:etiology; D013739:Testosterone / Q000097:blood
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol