title: Validation of esophageal pressure occlusion test after paralysis.
abstract: Measurements of respiratory mechanics are frequently made in ventilated infants and children. Esophageal pressure measurements (Pes) using a balloon on a catheter have been used to partition the respiratory mechanics into lung and chest wall components. Appropriate positioning of this balloon is crucial to obtain accurate estimates of pleural pressure. Traditionally, in spontaneously breathing subjects the balloon position is assessed with an occlusion test. In ventilated subjects, it is not always possible to perform an occlusion test prior to paralysis, and even if such a test is performed it may be relevant under conditions of positive pressure ventilation. By occluding the airway opening and applying gentle pressure to the abdomen or rib cage, positive swings in pressure can be measured by both Pes and airway opening pressure (Pao). We compared traditional occlusion tests measured in 16 spontaneously breathing puppies to the positive pressure occlusion test performed after paralysis. In 2 pups we were unable to obtain a reasonable traditional occlusion test (> 15% difference between Pes and Pao) but we obtained 10 traditional occlusion tests in each of the remaining 14 pups (2.1-14 kg). In 11 of these animals delta Pes was within 10% of delta Pao. This compared well to positive pressure occlusion test using abdominal pressure performed after analysis, where delta Pes was within 10% of delta Pao in 10 animals. In 9 of these pups occlusion tests were also performed by applying pressure on the rib cage, where delta Pes was within 10% of delta Pao in 6 animals.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Clinical Sciences, Western Australian Research Institute for Child Health, Perth.
authors.forename: C J
authors.initials: CJ
authors.lastname: Lanteri
authors.forename: S
authors.initials: S
authors.lastname: Kano
authors.forename: P D
authors.initials: PD
authors.lastname: Sly
mesh_terms: D000818:Animals; D002404:Catheterization; D004285:Dogs; D004947:Esophagus / Q000502:physiology*; D010197:Pancuronium / Q000494:pharmacology; D010243:Paralysis / Q000503:physiopathology; D010994:Pleura / Q000502:physiology*; D011175:Positive-Pressure Respiration; D011312:Pressure; D015203:Reproducibility of Results; D015656:Respiratory Mechanics / Q000502:physiology*
chemical_list: D010197:Pancuronium