[Lymphocyte subsets and interleukin-2 receptor in breast cancer patients].
The lymphocyte subsets and IL-2R (p55/Tac) in breast cancer patients were analyzed using monoclonal antibody and flow cytometry until 6 post-operative month. Results were as follows: 1. Lymphocyte fraction of CD3, 4, 8 was maintained from pre-operative to post-operative 6 month. 2. IL-2R value was lower in recurrence group than in breast benign disease group and it was lower. In pre-operative IL-2R in Stage III group than in Stage I and, Stage II. It was lower in DNA aneuploidy group than in DNA diploidy group. 3. At the post-operative 6 month, IL-2R was higher in Stage III group, ly-factor positive group, v-factor positive group and DNA aneuploidy group than in recurrence group. When breast cancer recurred after resection, IL-2R value returned to initial value. In conclusion, IL-2R may be possibly one of the factors of recurrence of breast cancer.
Yokose
H
H
Department of Surgery, St. Marianna University School of Medicine, Toyoko Hospital, Kawasaki, Japan.
Komoriyama
H
H
Akaishi
O
O
Morikubo
M
M
Yamanaka
T
T
Yamaguchi
S
S
Katayama
K
K
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D017252:CD3 Complex / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D016131:Lymphocyte Subsets; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D017252:CD3 Complex; D016827:CD8 Antigens; D015375:Receptors, Interleukin-2