Detection of brain activation using oxygenation sensitive functional spectroscopy.
A nonwater-suppressed localized spectroscopy experiment using the PRESS-sequence has been used to study the signal changes of the water resonance during cortical activation. Significant effects with an effect-to-noise ratio up to 50:1 for a single shot experiment have been observed upon photic stimulation. The exceedingly high signal-to-noise ratio of the experiment was used to demonstrate signal changes as low as 0.1% after electrical stimulation of the median nerve.
Hennig
J
J
Radiologische Klinik, Abt. Röntgendiagnostik, Neurologische Klinik, University Freiburg, Germany.
Ernst
T
T
Speck
O
O
Deuschl
G
G
Feifel
E
E
D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010775:Photic Stimulation