Molecular biology of brain tumors.
Molecular technology has opened new vistas in the analysis of brain tumors. It appears that, for most tumors, there is a complex interaction between two sets of genes--the oncogenes and tumor suppressor genes. The successive mutation and loss of these genes lead to the multistep process of tumor formation. In this article, current understanding of the genetic aberrations in a number of primary human brain tumors is discussed.
Wu
J K
JK
New England Medical Center, Boston, Massachusetts.
Naber
S P
SP
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D009857:Oncogenes / Q000235:genetics*