title: Hyperaemia prior to acute cerebral swelling in severe head injuries: the role of transcranial Doppler monitoring.
abstract: Acute cerebrovascular congestion after a closed head injury is significantly related to intracranial hypertension. As an indirect method of cerebral blood flow measurement; transcranial doppler sonography (TCD) provides a rapid and noninvasive assessment of cerebral haemodynamics, including hyperaemic conditions. TCD examinations was serially performed in 35 patients with severe head injury with intact cerebral circulation; i.e. the mean flow velocity (MFV) patterns of the middle cerebral artery (MCA) did not show signs of cerebral circulatory arrest such as systolic spike, to and fro, or no flow. The results showed that the MFV of the MCAs and ipsilateral extracranial internal carotid arteries (ICAs) in 9 of these patients increased sharply and pulsatility index (PI) decreased during 48-96 hours after the injury. This was soon followed by patterns of high intracranial resistance, consistent with elevated intracranial pressure (ICP) in monitored patients and acute brain swelling on repeated computed tomographic (CT) scans. The correlation between increased MFVs, decreased PIs, and cerebral haemodynamic changes leading to acute brain swelling is discussed. The number of patients who ended with severe disability, vegetative state, or death was 66% in this group of 9 patients, compared to only 34% for the 35 patients overall with severe head injury. Though the morbidity and mortality rates largely depend on the primary injury, the presence of acute cerebral swelling aggravate the grave course in these patients. And the ability of TCD to monitor the hyperaemic state prior to oedema should lead us to adjust the therapy in order to minimize the secondary insult related to intracranial hypertension.
authors.affiliation: Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Muttaqin
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
authors.forename: S
authors.initials: S
authors.lastname: Kuwabara
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: K
authors.initials: K
authors.lastname: Kurisu
authors.forename: S
authors.initials: S
authors.lastname: Ohba
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Ogasawara
authors.forename: M
authors.initials: M
authors.lastname: Ohtani
authors.forename: T
authors.initials: T
authors.lastname: Mikami
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D001929:Brain Edema / Q000000981:diagnostic imaging* / Q000401:mortality; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D016489:Head Injuries, Closed / Q000000981:diagnostic imaging* / Q000401:mortality; D006801:Humans; D006940:Hyperemia / Q000000981:diagnostic imaging* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011673:Pulsatile Flow / Q000502:physiology; D015996:Survival Rate; D017585:Ultrasonography, Doppler, Transcranial