title: Pancytopenia secondary to lymphoid leukemia in three horses.
abstract: Pancytopenia was observed in two 3-year-old geldings and one 11-year-old mare. All horses had a brief history (2 days to 4 weeks) of fever, anorexia, and depression. One of the three horses had blast cells present on a peripheral blood smear. Examination of the bone marrow showed substantial infiltration with neoplastic lymphoid cells. At necropsy, neoplastic cells were restricted to the bone marrow in one horse, present in bone marrow, liver, and spleen in the second horse, and reported in multiple tissues in the third horse, including bone marrow, kidneys, lung, myocardium and lymph nodes. The value of a bone marrow aspirate and core biopsy in the investigation of pancytopenia is highlighted.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
authors.forename: G D
authors.initials: GD
authors.lastname: Lester
authors.forename: A R
authors.initials: AR
authors.lastname: Alleman
authors.forename: R E
authors.initials: RE
authors.lastname: Raskin
authors.forename: J C
authors.initials: JC
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006734:Horse Diseases / Q000473:pathology; D006736:Horses; D007945:Leukemia, Lymphoid / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010198:Pancytopenia / Q000209:etiology / Q000473:pathology / Q000662:veterinary*