title: Familial scrapie cases with shortened incubation periods.
abstract: Two familial scrapie cases successively occurred in 29-month-old and 30-month-old Corriedale dams and in three of their offspring as early as 10-19 months of age in a small flock. They showed ataxy but no pruritus. Histopathological and immunochemical examinations of those sheep revealed vacuolation of nerve cells in brain tissue and presence of PrPsc, a component of scrapie-associated fibrils, in brain, spleen and lymph node tissues. We discuss about shortened incubation periods and lacking pruritus in the present scrapie cases.
authors.affiliation: Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shinagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Muramatsu
authors.forename: A
authors.initials: A
authors.lastname: Onodera
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Horiuchi
authors.forename: N
authors.initials: N
authors.lastname: Ishiguro
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D015153:Blotting, Western; D005260:Female; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D009474:Neurons / Q000473:pathology; D018620:PrPSc Proteins; D011328:Prions / Q000302:isolation & purification; D012608:Scrapie / Q000473:pathology* / Q000503:physiopathology / Q000635:transmission; D012756:Sheep
chemical_list: D018620:PrPSc Proteins; D011328:Prions