[Extra-abdominal fibromatosis. An immunohistochemical analysis].
A 49-year-old patient presented with a slow-growing tumour on his back, which had been present for 10 years. Histologically an infiltrating spindle-cell tumour without cell polymorphism was found. Each cell was surrounded by collagen fibrils. Immunohistochemically the tumour cells showed positive staining with antibodies to alpha-smooth muscle actin, factor XIIIa, CD34 and vimentin. In contrast, antibodies to the intermediate filament protein desmin, glial fibrillary acid protein (GFAP), the neurofilament (NF), neuron-specific enolase (NSE), S-100 protein, carcinoembryonic antigen (CEA) and keratin protein (LU-5) revealed no staining of the spindle cells. This immunohistochemical profile supports myofibroblastic differentiation of the spindle cell in extra-abdominal fibromatosis.
Schirren
C G
CG
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Schirren
H
H
Gyzicki-Nienhaus
B
B
Kind
P
P
D014408:Biomarkers, Tumor / Q000032:analysis*; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D013524:Surgical Flaps
D014408:Biomarkers, Tumor
Extraabdominale Fibromatose. Eine immunhistochemische Analyse.