title: The influence of thoracic epidural analgesia alone and in combination with general anesthesia on cardiovascular function and myocardial metabolism in patients receiving beta-adrenergic blockers.
abstract: Thoracic epidural analgesia combined with chronic beta-adrenergic blocker medication may cause cardiac depression. We investigated the cardiovascular and myocardial metabolic effects of a T1-T12 epidural block in 18 patients (age < 65 yr, ejection fraction > 0.5), receiving chronic beta-adrenergic blocker medication and scheduled for aortocoronary bypass surgery. After randomization into a light or deeper general anesthetic group, the cardiovascular and myocardial metabolic effects of a subsequent general anesthesia induction were investigated. Thoracic epidural analgesia induced a moderate decrease in mean arterial pressure, coronary perfusion pressure, free fatty acids, and myocardial consumption of free fatty acids. General anesthesia with thiopental (2-4 mg/kg) and a low fentanyl dose (5 micrograms/kg) increased heart rate, coronary perfusion pressure, and coronary vascular resistance, whereas mean pulmonary arterial pressure and pulmonary capillary wedge pressure decreased. After thiopental (2-4 mg/kg) and a high fentanyl dose (30 micrograms/kg), mean arterial pressure and left ventricular stroke work index decreased. We conclude that a T1-T12 epidural block in well sedated, beta-adrenergic blocked patients does not induce clinically significant cardiovascular effects. Induction of general anesthesia was well tolerated, but the light general anesthetic could not prevent an increase in heart rate and coronary vascular resistance, whereas the deeper anesthetic induced slight myocardial depression. No effect on the atrioventricular conduction, as measured by the PQ-time, was noted.
authors.affiliation: Department of Anaesthesiology, Regional Hospital, University of Trondheim, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Stenseth
authors.forename: E M
authors.initials: EM
authors.lastname: Berg
authors.forename: L
authors.initials: L
authors.lastname: Bjella
authors.forename: O
authors.initials: O
authors.lastname: Christensen
authors.forename: O W
authors.initials: OW
authors.lastname: Levang
authors.forename: S E
authors.initials: SE
authors.lastname: Gisvold
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000698:Analgesia; D000768:Anesthesia, General; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism*; D004347:Drug Interactions; D005283:Fentanyl; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*
chemical_list: D000319:Adrenergic beta-Antagonists; D005283:Fentanyl