title: Sulfasalazine-associated encephalopathy in a patient with Crohn's disease.
abstract: We report a case of acute encephalopathy in a patient with Crohn's disease who had taken sulfasalazine for 1 month. The development of a toxic hepatitis and dermatitis prompted interruption of the drug. Four days later, neurological symptoms became evident. These included acute monoparesis of the left arm, the development of stupor and coma, with endorotation of both arms and a left Babinski sign. CT and magnetic resonance imaging revealed multiple lesions in the white and gray brain matter, suggesting diffuse cerebral microangiitis. All cerebrospinal fluid examinations were negative. Methylprednisolone was given intravenously. Complete clinical normalization followed. Neurotoxicity secondary to sulfasalazine has seldom been reported in the literature. We found certain similarities between this case and two previous case reports suggesting a hypersensitivity reaction to sulfasalazine or one of its metabolites. For ethical reasons, no rechallenge was performed.
authors.affiliation: Department of Gastroenterology, Algemene Kliniek H. Familie, Ghent, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Schoonjans
authors.forename: A
authors.initials: A
authors.lastname: Mast
authors.forename: G
authors.initials: G
authors.lastname: Van Den Abeele
authors.forename: D
authors.initials: D
authors.lastname: Dewilde
authors.forename: E
authors.initials: E
authors.lastname: Achten
authors.forename: V
authors.initials: V
authors.lastname: Van Maele
authors.forename: W
authors.initials: W
authors.lastname: Pauwels
mesh_terms: D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003128:Coma / Q000139:chemically induced; D003424:Crohn Disease / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012460:Sulfasalazine / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D012460:Sulfasalazine