Somatostatin inhibits cell proliferation and corticosterone secretion in the early stage of adrenal regeneration.
Somatostatin was given to male Wistar rats subjected to adrenal enucleation combined with monoadrenalectomy. It was found that somatostatin (25 micrograms/kg) inhibited both cell proliferation and corticosterone output on the fourth and on the eighth days of adrenal regeneration.
Zieleniewski
W
W
Clinic of Endocrinology, Institute of Endocrinology, Lódź, Poland.
Zieleniewski
J
J
D000305:Adrenal Cortex Hormones / Q000097:blood / Q000378:metabolism*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D008297:Male; D008940:Mitotic Index; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D013004:Somatostatin