Successful management of a pregnancy with maternal phenylketonuria: report of a case.
Maternal phenylketonuria (PKU) is associated with significant complications such as mental retardation, microcephaly and congenital heart defects in nonphenylketonuric offspring. Dietary control with a low phenylalanine diet during the gestation period is effective in improving perinatal outcome in these cases. We present the case of a 27-year-old woman with classical features of PKU who had previously given birth to three babies, all of whom died of congenital heart disease. A low phenylalanine diet was started one month prior to the pregnancy and satisfactory fetal outcome was achieved.
Huang
R T
RT
Department of Obstetrics & Gynecology, National Cheng-Kung University Medical Center, Tainan, Taiwan, R.O.C.
Lin
S J
SJ
Kuo
P L
PL
Peng
C J
CJ
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010661:Phenylketonurias / Q000178:diet therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy*; D011295:Prenatal Care