title: Selective intrabronchial instillation of surfactant in a patient with pneumonia: a preliminary report.
abstract: The efficacy of treatment with exogenous surfactant has been reported in children with respiratory failure due to severe pneumonia. Its effect in adults with similar features has not been established. We therefore administered 240 mg of surfactant to a 71 year old man, who had developed right lower lobe pneumonia and hypoxaemia following abdominal aortic surgery. After this treatment, the patient's oxygenation, evaluated by arterial oxygen tension/fraction of inspired oxygen (PaO2/FIO2) ratio during artificial ventilation, gradually improved, and ventilator settings could be reduced whilst maintaining PaO2 at the appropriate level. Although the precise mechanism by which surfactant improves respiratory failure due to pneumonia is unclear, administration of the drug may have overcome a quantitative deficiency of endogenous surfactant attributable to the antagonistic effect of pulmonary exudates and reduced production following damage to type II pneumocytes. The present case provides an indirect suggestion of a possible causal relationship between the improvement of oxygenation and administration of surfactant in adult respiratory failure caused by pneumonia.
authors.affiliation: Dept of Anaesthesiology, Kobe University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mikawa
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Nishina
authors.forename: Y
authors.initials: Y
authors.lastname: Takao
authors.forename: H
authors.initials: H
authors.lastname: Yaku
authors.forename: H
authors.initials: H
authors.lastname: Obara
mesh_terms: D000368:Aged; D000818:Animals; D001688:Biological Products; D001980:Bronchi; D002417:Cattle; D006801:Humans; D008297:Male; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy*; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D012131:Respiratory Insufficiency / Q000188:drug therapy
chemical_list: D001688:Biological Products; D011663:Pulmonary Surfactants; C072197:beractant