Calcitonin gene-related peptide-like immunoreactive (CGRPI) elements in the circadian system of the mouse: an immunohistochemistry combined with retrograde transport study.
This study was based on immunohistochemical detection of calcitonin gene-related peptide-like immunoreactive (CGRPI) neurons and fibers in the suprachiasmatic nucleus (SCN) and intergeniculate leaflet (IGL) of the mouse. CGRPI neurons and fibers were found within the ventrolateral part of the SCN, in the whole extent of IGL and sparsely distributed in ventral lateral geniculate body. The presence of CGRPI structures in the SCN and IGL of the mouse further supports the hypothesis of differences in the content of neuroactive substances in the circadian clock between mammalian species. Fluorogold retrograde transport combined with CGRP immunofluorescence demonstrates that CGRPI neurons in the IGL constitute a part of IGL reciprocal connections.
Park
H T
HT
Department of Anatomy, College of Medicine, Pusan National University, Suh-Gu, South Korea.
Baek
S Y
SY
Kim
B S
BS
Kim
J B
JB
Kim
J J
JJ
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005456:Fluorescent Dyes; D005829:Geniculate Bodies / Q000378:metabolism* / Q000502:physiology; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009412:Nerve Fibers / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D013266:Stilbamidines; D013493:Suprachiasmatic Nucleus / Q000378:metabolism* / Q000502:physiology
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines; D015740:Calcitonin Gene-Related Peptide