title: The induction of epidermal ornithine decarboxylase following UV-B irradiation is inhibited by estriol.
abstract: The induction of epidermal ornithine decarboxylase (ODC) can be partially blocked by corticosteroids, retinoic acid or active vitamin D3. The influence of the other members of this so-called "steroid hormone receptor superfamily", namely the sex-steroids and thyroid hormone, is unknown in epidermis, but they enhance ODC induction in certain other tissues. Here we investigated whether topical estriol leads to a spontaneous and/or enhanced epidermal ODC induction 8 h after UV-B irradiation of 6 postmenopausal women. Contrary to expectation, estriol did not stimulate induction but reduced induction by 44%. This observation raises the possibility that all members of the steroid hormone receptor superfamily may share a common AP-1 binding site.
authors.affiliation: Department of Dermatology, University Hospital Nijmegen, The Netherlands.
authors.forename: W P
authors.initials: WP
authors.lastname: Arnold
authors.forename: B J
authors.initials: BJ
authors.lastname: Pennings
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D004964:Estriol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000187:drug effects* / Q000528:radiation effects*; D065108:Ornithine Decarboxylase Inhibitors; D010865:Pilot Projects; D011829:Radiation Dosage; D012867:Skin / Q000201:enzymology / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D065108:Ornithine Decarboxylase Inhibitors; D009955:Ornithine Decarboxylase; D004964:Estriol