Increased ascitic fluid prorenin in the ovarian hyperstimulation syndrome.
Three patients developed severe ovarian hyperstimulation syndrome (OHS) as a complication of ovarian hyperstimulation for in vitro fertilization. These patients presented with ovarian enlargement, vascular volume depletion, pleural effusions, and exudative ascites. A unique feature of the ascites in OHS was the markedly elevated renin concentration, the majority of which was prorenin. We speculate the renin-angiotensin system (RAS) may play a pathophysiologic role in the localized capillary leak that develops in OHS.
Rosenberg
M E
ME
Department of Medicine, University of Minnesota, Minneapolis.
Mckenzie
J K
JK
Mckenzie
I M
IM
Junaid
A
A
Tagatz
G E
GE
D000328:Adult; D001202:Ascitic Fluid / Q000201:enzymology*; D004792:Enzyme Precursors / Q000378:metabolism*; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000201:enzymology*; D012083:Renin / Q000378:metabolism*
D004792:Enzyme Precursors; D012083:Renin