Suppressive effects of elimination diets on T cell responses to ovalbumin in hen's egg-sensitive atopic dermatitis patients.
We investigated the effect of elimination diets on T cell responses to ovalbumin (OA) in hen's egg-sensitive atopic dermatitis (AD) patients. The proliferative responses of both peripheral blood mononuclear cells (PBMCs) and T cells with monocytes to OA decreased after elimination diets, but those to Candida albicans or phytohemagglutinin (PHA) did not decrease after elimination diets. The proliferative responses of CD4+ T cells with monocytes to OA decreased after elimination diets. In these patients, clinical symptoms of AD improved. These results indicate that T cells, especially CD4+ T cells, respond to food antigens in food-specific lymphocyte responses, and that elimination diets may be able to initiate reduction of the responsiveness of food-sensitive T cells, especially CD4+ T cells. Moreover, the surface marker phenotypes of the T cells responding to OA were analysed. Our results showed that CD4+CD45RA+ T cells tended to increase. The increase in circulating CD4+CD45RA+ T cells might function as systemic suppression against immune responses in the skin.
Shinoda
S
S
Department of Pediatrics, Gifu University School of Medicine, Japan.
Kondo
N
N
Fukutomi
O
O
Agata
H
H
Suzuki
Y
Y
Shimozawa
N
N
Tomatsu
S
S
Yamada
Y
Y
Takemura
M
M
Noma
A
A
D000293:Adolescent; D000954:Antigens, Surface / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000178:diet therapy* / Q000276:immunology; D004531:Eggs / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000178:diet therapy* / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007165:Immunosuppression Therapy; D007223:Infant; D008213:Lymphocyte Activation / Q000276:immunology; D008934:Mitogens / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D010047:Ovalbumin / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000954:Antigens, Surface; D008934:Mitogens; D010047:Ovalbumin