[The mechanisms of the antidotal action of bispyridinium oximes when used in combination with M-cholinolytics in dimethyl dichlorovinyl phosphate poisoning].
The results of in vitro and in vivo experiments were used to compare the capacity of bispiridinium oximes to modulate the presynaptic secretion of acetylcholine and to demonstrate the protective activity against organophosphate intoxication during combined application with various M-cholinolytics. It is suggested that bispiridinium oximes combined with M-cholinolytics can play a corrective role in eliminating the adverse presynaptic effect of a cholinolytic, thus lowering the severity of intoxication.
Filipppov
V N
VN
Podosinovikova
N P
NP
Kosmachev
A B
AB
Dolgo-Saburov
V B
VB
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000931:Antidotes / Q000494:pharmacology / Q000627:therapeutic use*; D004006:Dichlorvos / Q000506:poisoning*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D066298:In Vitro Techniques; D010091:Oximes / Q000494:pharmacology / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000494:pharmacology / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000503:physiopathology; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D011726:Pyridinium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D000931:Antidotes; D010091:Oximes; D010276:Parasympatholytics; D011726:Pyridinium Compounds; D004006:Dichlorvos; D000109:Acetylcholine
Mekhanizmy antidotnogo deĭstviia bispiridinievykh oksimov v usloviiakh ikh kombinirivannogo primeneniia s M-kholinolitikami pri otravlenii dimetildikhlorvinilfosfatom.