title: Striatal [11C]-N-methyl-spiperone binding in patients with focal dystonia (torticollis) using positron emission tomography.
abstract: Specific binding of [11C]-N-methyl-spiperone to striatal dopamine D2 receptors was assessed using positron emission tomography (PET) in 6 patients with adult-onset focal dystonia (predominantly spasmodic torticollis) and in 5 healthy subjects. No significant difference in average specific striatal tracer uptake between patients and healthy subjects was found. However, in the 5 patients showing lateralisation of clinical signs a trend to higher striatal tracer uptake in the contralateral hemisphere was observed.
authors.affiliation: Paul Scherrer Institute, Villigen, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Leenders
authors.forename: P
authors.initials: P
authors.lastname: Hartvig
authors.forename: L
authors.initials: L
authors.lastname: Forsgren
authors.forename: G
authors.initials: G
authors.lastname: Holmgren
authors.forename: B
authors.initials: B
authors.lastname: Almay
authors.forename: S A
authors.initials: SA
authors.lastname: Eckernäs
authors.forename: H
authors.initials: H
authors.lastname: Lundqvist
authors.forename: B
authors.initials: B
authors.lastname: Långström
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D015259:Dopamine Agents / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013134:Spiperone / Q000031:analogs & derivatives* / Q000378:metabolism; D014055:Tomography, Emission-Computed; D014103:Torticollis / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D015259:Dopamine Agents; D017448:Receptors, Dopamine D2; D013134:Spiperone; C039167:3-N-methylspiperone