title: Frequency of RAS and p53 mutations in acute promyelocytic leukemias.
abstract: The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.
authors.affiliation: Istituto Clinica Medica I, University of Perugia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Longo
authors.forename: D
authors.initials: D
authors.lastname: Trecca
authors.forename: A
authors.initials: A
authors.lastname: Biondi
authors.forename: F
authors.initials: F
authors.lastname: Lo Coco
authors.forename: F
authors.initials: F
authors.lastname: Grignani
authors.forename: A T
authors.initials: AT
authors.lastname: Maiolo
authors.forename: P G
authors.initials: PG
authors.lastname: Pelicci
authors.forename: A
authors.initials: A
authors.lastname: Neri
mesh_terms: D001483:Base Sequence; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000209:etiology / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation