Influence of growth factors and substrates on differentiation of haemopoietic stem cells.
During the last few years there has been major progress in our understanding of the mechanisms underlying the regulation of haemopoietic stem cell proliferation and development. In the past 12 months, advances have been made in identifying how growth factor receptor expression is regulated in primitive haemopoietic cells, in determining the transcription factors that are associated with development, and in recognizing some of the specific molecular interactions that occur between the bone marrow stromal cells and the haemopoietic progenitor cells. These and previous studies clearly demonstrate that the environment can influence the survival, the proliferation and the differentiation of haemopoietic cells at every stage of development.
Whetton
A D
AD
Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Dexter
T M
TM
D000818:Animals; D017209:Apoptosis; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D003239:Connective Tissue Cells; D003470:Culture Media; D018014:Gene Transfer Techniques; D006131:Growth Inhibitors / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology
D003470:Culture Media; D006131:Growth Inhibitors; D016298:Hematopoietic Cell Growth Factors; D011956:Receptors, Cell Surface