[Membranotropic properties of conjugates of proteins with ethylene oxide and propylene oxide block copolymers].
It has earlier been established that conjugates of hydrophilic proteins with block copolymers of ethylene oxide and propylene oxide (proxanols) used at low concentrations decrease the oxidation of NAD-dependent substrates in mitochondria and cells. The dependence of this property on the chemical structure and structural organization of such conjugates has been studied. The conjugates have been shown to inhibit the oxygen consumption of lymphocytes when the hydrophobic (polypropylene oxide) blocks are located on the periphery of the conjugate and the polymer chains form domains that are irregularly distributed on the protein globule surface. The minimum number of the polymer chains in the conjugate sufficient to provide this property is three. Additional evidence has been obtained in favour of the ability of conjugates to penetrate through the cellular membrane of lymphocytes.
Topchieva
I N
IN
Mokhova
E N
EN
Kirillova
G P
GP
Efremova
N V
NV
D002462:Cell Membrane / Q000378:metabolism; D005027:Ethylene Oxide / Q000737:chemistry / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D011108:Polymers; D011506:Proteins; D009243:NAD; D011092:Polyethylene Glycols; D005027:Ethylene Oxide
Membranotropnye svoĭstva kon''iugatov belkov s blok-sopolimerami okisiétilena i okisi propilena.