[The calcium-binding properties of the plasma proteins from patients with aseptic necrosis of bone following a cadaveric kidney allograft].
Calcium-binding properties of plasma proteins in hypo- and hypercalcaemia, induced in vitro, were studied at late posttransplantation periods in 15 recipients of cadaveric kidney, 8 of whom showed aseptic necrosis (AN) of the femur heard. Immunosuppression included prednisolone and azathioprine with analogous mean monthly doses in all recipients. Langmuir and Scatchard analysis revealed lowering of specific and total buffer capacity of plasma proteins (beta SP., beta pr) in hypercalcemia only in AN recipients at the expense of decreased Na and increased Ka during calcium binding by independent protein sites.
Sokolova
T Iu
TIu
Pronchenko
I A
IA
Biriukova
L S
LS
Sevost'ianov
V A
VA
Ermakova
I P
IP
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D002102:Cadaver; D002135:Calcium-Binding Proteins / Q000097:blood* / Q000187:drug effects; D005271:Femur Head Necrosis / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000502:physiology* / Q000706:statistics & numerical data; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D011239:Prednisolone / Q000008:administration & dosage; D013997:Time Factors; D014184:Transplantation, Homologous
D002135:Calcium-Binding Proteins; D011239:Prednisolone; D001379:Azathioprine
Kal'tsiĭsviazyvaiushchie svoĭstva plazmennykh belkov u bol'nykh s asepticheskimi nekrozami kosteĭ posle allotransplantatsii trupnoĭ pochki.