The protective effect of prostaglandin I2 analog (OP-41483) on hemodynamics and oxygen metabolism in normothermic liver ischemia.
The purpose of this study was to estimate the effect of OP-41483 (Prostaglandin I2 analog) on normothermic liver ischemia by measuring the systemic and hepatic hemodynamics, oxygen metabolism, hematological and biochemical data. Sixty minutes of normothermic ischemia was induced by cross-clamping the hepatic artery and the portal vein with the bypass. The animals, weighing 10 to 15 kg, were divided into three groups: animals (n = 7) given no drugs (group I), those (n = 7) given OP-41483 (0.4 microgram/kg/min) for 30 minutes prior to the initiation of ischemia and after the beginning of reperfusion (group II), and those (n = 7) given OP-41483 (0.4 microgram/kg/min) for 30 minutes before ischemia and 3 hours after reperfusion (group III). The total hepatic blood flow was significantly higher 30 minutes after reperfusion in groups II and III than in group I (p < 0.05). The oxygen delivery to the liver and oxygen consumption in the liver decreased after reperfusion in group I, but there were no significant differences in these values before and after hepatic ischemia in groups II and III. The hepatic tissue blood flow was significantly higher in groups II and III than in group I after reperfusion. In group III, oxygen consumption in the liver was significantly higher 2 to 3 hours after reperfusion than in groups I and II. The systemic oxygen consumption after reperfusion recovered more rapidly in groups II and III than in group I. These results indicate that OP-41483 has a beneficial effect on the recovery of the hepatic microcirculation affected by ischemia.
Saito
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Department of Surgery I, Fukushima Medical College, Japan.
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D007511:Ischemia / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism; D008102:Liver Circulation; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects
D011464:Epoprostenol; C035847:ataprost; D010100:Oxygen