title: Assessment of the oral administration of a high dose of retinol on vitamin E status of sheep.
abstract: The effect of dietary excess of retinol on vitamin E turnover in sheep's body was studied. Five of 10 adult Canadian Arcott sheep were given daily for 30 d an oral dose of 250 mg vitamin A as retinol palmitate, while the remaining sheep were used as control. Then a single oral dose of D-alpha(5-Me-3H) tocopherol (0.2 microCi/kg vitamin B) was administered to each sheep in both groups. The kinetic data were modelled as a 2-compartment model which provided a simple kinetic description of vitamin E absorption. The analysis showed no difference between the 2 groups of sheep regarding their various pharmacokinetic values. It is suggested that oversupply of dietary retinol does not antagonize vitamin E turnover in the sheep.
authors.affiliation: Food and Animal Research Center, Agriculture Canada, Ottawa, Ontario.
authors.forename: M
authors.initials: M
authors.lastname: Hidiroglou
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D004347:Drug Interactions; D008297:Male; D012756:Sheep / Q000378:metabolism*; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D002214:Capsules; D014801:Vitamin A; D014810:Vitamin E