Age-related increase of CD45RO+ lymphocytes in physically active adults.
The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD45RO+ (r = 0.648) within the CD4+ population, percentage of CD8+ CD45RO+ cells within the CD8+ lymphocytes (r = 0.498) and total lymphocyte number (r = -0.242) correlated significantly (p < 0.001) with age. We conclude that the age-related increase of CD45RO+ T cells indicates a gradual increase of activated T cells.
Gabriel
H
H
Institute of Sports and Performance Medicine, University of Saarland, Saarbrücken, FRG.
Schmitt
B
B
Kindermann
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D016827:CD8 Antigens / Q000378:metabolism; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000378:metabolism*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010809:Physical Fitness; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
D016827:CD8 Antigens; D017493:Leukocyte Common Antigens