title: Phospholipase-like myotoxins induce rapid membrane leakage of non-hydrolyzable ether-lipid liposomes.
abstract: Two phospholipase-like myotoxins--ammodytin L from Vipera ammodytes and myotoxin II from Bothrops asper--are shown to be able to induce leakage of liposomes made from non-hydrolyzable ether-linked phospholipids. This demonstrates that the cytolytic activity of these toxins is completely independent of any remaining enzyme activity or contamination with active phospholipases.
authors.affiliation: Department of Biology, University of Rome Tor Vergata, Italy.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Pedersen
authors.forename: B F
authors.initials: BF
authors.lastname: de Arcuri
authors.forename: R D
authors.initials: RD
authors.lastname: Morero
authors.forename: S
authors.initials: S
authors.lastname: Rufini
mesh_terms: D003435:Crotalid Venoms / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D005454:Fluorescence Polarization; D054501:Group II Phospholipases A2; D008081:Liposomes / Q000737:chemistry*; D009498:Neurotoxins / Q000494:pharmacology*; D010741:Phospholipases A / Q000494:pharmacology*; D010742:Phospholipid Ethers / Q000737:chemistry; D030162:Reptilian Proteins; D014757:Viper Venoms / Q000494:pharmacology*
chemical_list: D003435:Crotalid Venoms; D008081:Liposomes; D009498:Neurotoxins; D010742:Phospholipid Ethers; D030162:Reptilian Proteins; D014757:Viper Venoms; C065419:ammodytin L; D010741:Phospholipases A; D054501:Group II Phospholipases A2; C061056:myotoxin II, Bothrops asper