Glycine: an important potential component of spinal shock.
Amino acid neurotransmitters (AANTs) play a major role in maintenance of muscle tone. Abnormal AANT concentrations are associated with hyper- or hypotonic states. Flaccidity from spinal shock commonly occurs after spinal cord injury (SCI) and may be associated with changes in AANT concentrations. Ischemic SCIs created in the lumbar region of rabbits by intraaortic balloon occlusion produced spastic or flaccid injuries. Microdialysis sampling of AANTs from the injured segmental structures was done 3 days after SCI. Evoked potentials were used to monitor spinal cord stability. No significant changes in AANT levels occurred in the spastic or flaccid group after 4 hour sampling. However, flaccid animals had baseline glycine levels 2-3 times higher (p < 0.001) than spastic animals or controls. High concentrations of the inhibitory AANT glycine is associated with flaccidity following SCI, or spinal shock, but not spasticity. Glycinergic compounds directed toward suppression of excess muscle tone deserve further study.
Simpson
R K
RK
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030.
Robertson
C S
CS
Goodman
J C
JC
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis; D005071:Evoked Potentials; D005998:Glycine / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011817:Rabbits; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000503:physiopathology*
D000596:Amino Acids; D018377:Neurotransmitter Agents; D005998:Glycine