title: Brain soluble and membrane-bound Tyr-aminopeptidase activities during the stages of estrous and proestrous in the female rat.
abstract: Brain Tyr-aminopeptidase activity levels during two stages of the rat estrous cycle (estrous and proestrous), are described in this research. The study includes the activities of the soluble and the membrane-bound forms. Soluble Tyr-aminopeptidase activity shows a significant increase during the proestrous stage in the hypothalamus. The complete membrane-bound activity did not significantly change at any point. However, a significant rise was found in the membrane-bound puromycin insensitive aminopeptidase activity in the hypothalamus and the pituitary gland during the proestrous phase.
authors.affiliation: Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: de Gandarias
authors.forename: J
authors.initials: J
authors.lastname: Irazusta
authors.forename: J
authors.initials: J
authors.lastname: Gil
authors.forename: D
authors.initials: D
authors.lastname: Fernández
authors.forename: L
authors.initials: L
authors.lastname: Casis
mesh_terms: D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D018826:CD13 Antigens; D004971:Estrus; D005260:Female; D005470:Fluorometry; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008566:Membranes / Q000201:enzymology; D011359:Proestrus; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility
chemical_list: D011691:Puromycin; D000626:Aminopeptidases; C025579:enkephalin degrading enzyme; D018826:CD13 Antigens; D007930:Leucine; C012211:ubenimex