[Distribution of immunoglobulin-containing cell subclasses in the mucosa of the small intestine in children with celiac disease].
The number of cells containing the various subclasses of IgG and IgA were measured using monoclonal in 20 small intestinal biopsy specimens taken from 16 coeliac children. From 8 coeliac patients specimens were taken before dietary treatment. Specimens were analysed from 7 patients on gluten free diet and from 5 after gluten challenge. In addition, 11 control specimens were studied. The cells of each IgG and IgA subclass were present in significantly higher densities in the specimens from the children with coeliac disease on a normal diet than in those from controls. The distribution of the different IgA and IgG subclasses did not differ significantly from that of controls. The significant increase of cells containing the different IgG and IgA subclasses in the small intestinal mucosa of coeliac children indicates that these cells play a role in the pathogenesis of this disease. The analysis of these cells may help in the histological diagnosis of coeliac disease.
Arató
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A
I. Gyermekklinika, Semmelweis Orvostudományi Egyetem, Budapest.
Savilahti
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E
D000911:Antibodies, Monoclonal / Q000276:immunology; D001706:Biopsy; D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000145:classification / Q000276:immunology; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology*; D008297:Male
D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007074:Immunoglobulin G
Az immunglobulin-tartalmú sejtek alosztálymegoszlása a coeliakiás gyermekek vékonybél-nyálkahártyájában.