Pharmacological effects of ibudilast on cerebral circulation: a PET study.
To evaluate the pharmacological effects of ibudilast on cerebral circulation, we examined 5 ischaemic stroke patients, using positron emission tomography, and we measured cerebral blood flow (CBF). Ibudilast loading per os led to a remarkable increase in CBF after 30 min. This CBF elevation was observed in the lesion side as well as in the nonlesion hemisphere. Therefore, we can confirm that ibudilast ameliorates the chronic low perfusion state of CBF in the ischaemic stroke patient.
Fukuyama
H
H
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Kimura
J
J
Yamaguchi
S
S
Yamauchi
H
H
Ogawa
M
M
Doi
T
T
Yonekura
Y
Y
Konishi
J
J
D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D014055:Tomography, Emission-Computed; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007212:Indolizines; D011720:Pyrazoles
D011464:Epoprostenol; D011725:Pyridines; D014665:Vasodilator Agents; C038366:ibudilast; D007212:Indolizines; D011720:Pyrazoles