Neuropeptide Y inhibits human and invertebrate immunocyte chemotaxis, chemokinesis, and spontaneous activation.
1. In a concentration-dependent manner neuropeptide Y was found to be a potent inhibitor of the spontaneous activation of human granulocytes and macrophages as well as Mytilus edulis immunocytes. 2. Neuropeptide Y also inhibited the chemotaxic response of these immunocytes to the chemoattractant f-MLP. 3. Incubation of both the human and the invertebrate immunocytes in f-MLP (10(-9) M) causes "activation" as noted by random locomotion (chemokinesis). Neuropeptide Y also blocked f-MLP-induced chemokinesis. 4. The results suggest that neuropeptide Y may, in addition to other functions, serve as an endogenous regulator of immunocyte function.
Dureus
P
P
Multidisciplinary Center for the Study of Aging, Old Westbury Neuroscience Research Institute, State University of New York/College at Old Westbury 11568.
Louis
D
D
Grant
A V
AV
Bilfinger
T V
TV
Stefano
G B
GB
D000818:Animals; D049872:Bivalvia; D002633:Chemotaxis / Q000187:drug effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology*
D009478:Neuropeptide Y; D009240:N-Formylmethionine Leucyl-Phenylalanine