title: Relevance of chlorine-substituent for the antifungal activity of syringomycin and syringotoxin, metabolites of the phytopathogenic bacterium Pseudomonas syringae pv. syringae.
abstract: Structural analogues of syringomycin and syringotoxin were produced by fermentation, characterized by FAB-MS and amino acid analysis and compared to the parent compounds in the antibiosis test against Rhodotorula pilimanae. The C-terminal residue was shown to be important for the activity.
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi-Fanelli, Università La Sapienza di Roma, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Grgurina
authors.forename: A
authors.initials: A
authors.lastname: Barca
authors.forename: S
authors.initials: S
authors.lastname: Cervigni
authors.forename: M
authors.initials: M
authors.lastname: Gallo
authors.forename: A
authors.initials: A
authors.lastname: Scaloni
authors.forename: P
authors.initials: P
authors.lastname: Pucci
mesh_terms: D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000737:chemistry / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic; D011549:Pseudomonas / Q000187:drug effects* / Q000472:pathogenicity; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D010456:Peptides, Cyclic; C032677:syringomycin; C069036:syringotoxin B