title: Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.
abstract: The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD). We have examined epsilon 4 frequencies in four distinct, normal, elderly control groups and, most importantly, in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known (Creutzfeldt-Jakob disease, familial amyloidotic polyneuropathy, Down's syndrome). There were no differences between any of these controls and published control series, cementing the relevance of epsilon 4 for late-onset AD. The increase in late-onset AD was confirmed in two new series.
authors.affiliation: Bryan Alzheimer's Disease Research Center, Division of Neurology, Duke University Medical Center, Durham, NC 27710.
authors.forename: A M
authors.initials: AM
authors.lastname: Saunders
authors.forename: K
authors.initials: K
authors.lastname: Schmader
authors.forename: J C
authors.initials: JC
authors.lastname: Breitner
authors.forename: M D
authors.initials: MD
authors.lastname: Benson
authors.forename: W T
authors.initials: WT
authors.lastname: Brown
authors.forename: L
authors.initials: L
authors.lastname: Goldfarb
authors.forename: D
authors.initials: D
authors.lastname: Goldgaber
authors.forename: M G
authors.initials: MG
authors.lastname: Manwaring
authors.forename: M H
authors.initials: MH
authors.lastname: Szymanski
authors.forename: N
authors.initials: N
authors.lastname: McCown
mesh_terms: D000367:Age Factors; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D000686:Amyloidosis / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics; D005787:Gene Frequency; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000235:genetics; D006801:Humans
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E