Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.
The rum1+ gene is identified as a new regulator of G1 progression in fission yeast. It influences three aspects of G1 regulation: determination of the length of G1, dependence of S phase upon completion of mitosis, and restraint of mitosis until G1 is finished. We propose that it has a central role in regulating the G1 phase of the cell cycle.
Moreno
S
S
Department of Biochemistry, Oxford University, London, UK.
Nurse
P
P
D000595:Amino Acid Sequence; D001483:Base Sequence; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics*; D019926:Cyclin B; D016213:Cyclins / Q000378:metabolism; D004261:DNA Replication / Q000235:genetics; D004271:DNA, Fungal / Q000096:biosynthesis; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology; D016193:G1 Phase / Q000235:genetics; D005800:Genes, Fungal; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation; D016196:S Phase / Q000235:genetics; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins; D014170:Transformation, Genetic
D019926:Cyclin B; D016213:Cyclins; D004271:DNA, Fungal; D005656:Fungal Proteins; C086077:Rum1 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins; D016203:CDC2 Protein Kinase