Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5.
Autosomal dominant cyclic hematopoiesis (ADCH), or cyclic neutropenia, is a genetic disorder characterized by cyclic oscillations of neutrophils and other blood cells. To determine if the gene for ADCH mapped within the major hematopoietic regulatory gene cluster at 5q23.3-q33.3, we tested five families with ADCH for genetic linkage between the disorder and loci on chromosome 5q. Two-point analyses gave significant evidence in favor of excluding linkage between ADCH and the hematopoietic genes granulocyte-macrophage colony-stimulating factor (CSF), interleukins 3, 4, 5, and 9, and the receptor of macrophage-CSF. Furthermore, the exclusion data provide evidence for rejecting the hypothesis that ADCH may be encoded by a new gene mapping within this cluster.
Palmer
S E
SE
Department of Medicine, University of Washington, Seattle 98195.
Dale
D C
DC
Livingston
R J
RJ
Wijsman
E M
EM
Stephens
K
K
D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008040:Genetic Linkage; D006410:Hematopoiesis / Q000235:genetics*; D016298:Hematopoietic Cell Growth Factors / Q000235:genetics*; D006801:Humans; D008297:Male; D005810:Multigene Family / Q000235:genetics*; D009503:Neutropenia / Q000235:genetics*; D010375:Pedigree; D016133:Polymerase Chain Reaction
D016298:Hematopoietic Cell Growth Factors