title: In vitro evidence of delayed-type hypersensitivity to hydrocortisone.
abstract: Hypersensitivity to topical hydrocortisone is becoming increasingly recognized. We present further evidence that this is mediated via a delayed-type hypersensitivity reaction. A hydrocortisone: albumin complex was able to induce a proliferative response in the peripheral blood mononuclear cells of patients allergic to hydrocortisone. Protein binding of hydrocortisone or a degradation product may be important in the development of corticosteroid allergy.
authors.affiliation: Department of Dermatology, Staffordshire Hospital Centre, Stoke-on-Trent, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Wilkinson
authors.forename: J S
authors.initials: JS
authors.lastname: English
authors.forename: D L
authors.initials: DL
authors.lastname: Mattey
mesh_terms: D000279:Administration, Cutaneous; D002455:Cell Division; D002478:Cells, Cultured; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000276:immunology*; D003875:Drug Eruptions / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D011485:Protein Binding; D012709:Serum Albumin / Q000009:adverse effects / Q000494:pharmacology; D013936:Thymidine
chemical_list: D012709:Serum Albumin; D013936:Thymidine; D006854:Hydrocortisone