A case of cerebral glioblastoma with extensive cerebrospinal fluid dissemination: diagnostic value of immunohistochemical examination and MR imaging.
A 9-year, 6-month-old boy presented with peripheral-type multiple cranial nerve palsy due to extensive cerebrospinal fluid (CSF) dissemination of intracranial glioblastoma multiforme. Tissue obtained from biopsy did not stain for glial fibrillary acidic protein (GFAP). The relationship between GFAP-negative tumor cells and extensive CSF dissemination agreed with recent reports. Magnetic resonance imaging with gadolinium-DPTA enhancement clearly depicted not only the cranial meningeal dissemination but also spinal metastasis. Magnetic resonance imaging showed undoubted usefulness in demonstrating disseminated glioblastoma.
Minami
T
T
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kai
T
T
Hirabaru
C
C
Ishii
E
E
Ueda
K
K
Egami
H
H
Takeshita
I
I
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002555:Cerebrospinal Fluid / Q000166:cytology*; D002648:Child; D003131:Combined Modality Therapy; D003287:Contrast Media; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary / Q000628:therapy; D019786:Gadolinium DTPA; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy
D003287:Contrast Media; D005904:Glial Fibrillary Acidic Protein; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA