title: [The effect of endothelin-1 on vascular adrenoreactivity. The participation of G-proteins and protein kinase C in vascular constriction under the action of endothelin-1].
abstract: The experiments performed in endothelin-denuded preparations (the strips of thoracic aorta and perfused tail arteries) showed that: 1) ET-1 exerts dose-dependent and slowly developing contractions and in subthreshold doses it potentiates vasoconstriction reactions to stimulate sympathetic nerve endings or phenylephrine exposure. 2) ion F(-), that activates G-proteins in the cell membranes, at a dose of 2 microM increased about two times the ET-1-induced vasoconstriction. 3) the aortic strip incubation with the protein kinase C inhibitor staurosporin led to a 50% decrease in the contraction amplitude. Results suggest that G proteins and protein kinase C may participate in the development of ET-1 induced vascular smooth muscle contraction.
authors.forename: T P
authors.initials: TP
authors.lastname: Storozhevykh
authors.forename: D V
authors.initials: DV
authors.lastname: Zagulova
authors.forename: V G
authors.initials: VG
authors.lastname: Pinelis
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Markov
authors.forename: M A
authors.initials: MA
authors.lastname: Medvedev
authors.forename: M R
authors.initials: MR
authors.lastname: Baskakov
authors.forename: E P
authors.initials: EP
authors.lastname: Chabrier
authors.forename: P
authors.initials: P
authors.lastname: Braque
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D016232:Endothelins / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology; D019204:GTP-Binding Proteins / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011493:Protein Kinase C / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology
chemical_list: D016232:Endothelins; D011942:Receptors, Adrenergic, alpha; D011493:Protein Kinase C; D019204:GTP-Binding Proteins
vernacular_title: Vliianie éndotelina-1 na adrenoreaktivnost' sosudov. Uchastie G-belkov i proteinkinazy C v suzhenii sosudov pri deĭstvii éndotelina-1.