[The effect of D-glucuronic acid on the regenerative processes of granulomonocytopoiesis in cytostatic-induced myelodepression].
Whether cytostatic-induced disorders of the blood system can be corrected with D-glucuronic acid has been studied in murine experiments. D-glucuronic acid has been demonstrated to selectively stimulate the processes of bone marrow granulomonocytopoiesis both in intact animals and in rats with bone marrow hypoplasia induced by cyclophosphanum. During D-glucuronic acid administration, stimulation of hemopoietic regenerative processes is followed by the development of granulocyte lineage hyperplasia in bone marrow, the rapid restoration of blood polymorphonuclear leukocyte and monocyte counts and the development of neutrophilia and monocytosis.
Gol'dberg
E D
ED
Dygaĭ
A M
AM
Karpova
G V
GV
Simanina
E V
EV
Khlusov
I A
IA
Shakhov
V P
VP
Agafonov
V I
VI
D000704:Analysis of Variance; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D003864:Depression, Chemical; D004347:Drug Interactions; D005965:Glucuronates / Q000494:pharmacology*; D020723:Glucuronic Acid; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D005965:Glucuronates; D020723:Glucuronic Acid; D003520:Cyclophosphamide
Vliianie D-gliukuronovoĭ kisloty na protsessy regeneratsii granulomonotsitopoéza pri tsitostaticheskoĭ mielodepressii.