title: Intramuscular selenium administration in selenium-deficient cattle.
abstract: Nine recently weaned Hereford heifers were randomly assigned to a control group (n = 3) or a treatment group (n = 6). The animals were selenium (Se) deficient (mean +/- SD blood Se concentration = 0.024 +/- 0.012 microgram/mL). They were maintained on a selenium-deficient diet, and on day 0 of the study the treatment group was given 0.05 mg Se/kg body weight intramuscularly, while the control group received a placebo. The Se concentration of blood, serum, and urine as well as the glutathione peroxidase (GSH-Px) activity of blood and serum was measured over an 84-day period. Peak blood Se and serum Se concentrations (mean +/- SD) in the treatment group occurred at 5 hours postinjection and were 0.131 +/- 0.028 microgram/mL and 0.154 +/- 0.027 microgram/mL, respectively. The mean blood Se concentration of the treatment group was greater (P < .05) than that of the control group for the first 28 days after injection. The mean serum Se concentration of the treatment group was greater (P < .05) than that of the control group for all times after injection, except for day 56. The mean (+/- SD) blood GSH-Px activity of the treatment group (12.0 +/- 2.3 mU/min/mg hemoglobin) was increased (P < .05) over the control group (2.0 +/- 1.4 mU/min/mg hemoglobin) by day 28 and continued to be greater (P < .05) throughout the 84 day postinjection period.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: California Veterinary Diagnostic Laboratory System (CVDLS), School of Veterinary Medicine, University of California-Davis 95610.
authors.forename: J
authors.initials: J
authors.lastname: Maas
authors.forename: J R
authors.initials: JR
authors.lastname: Peauroi
authors.forename: T
authors.initials: T
authors.lastname: Tonjes
authors.forename: J
authors.initials: J
authors.lastname: Karlonas
authors.forename: F D
authors.initials: FD
authors.lastname: Galey
authors.forename: B
authors.initials: B
authors.lastname: Han
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003677:Deficiency Diseases / Q000188:drug therapy / Q000662:veterinary; D005260:Female; D005979:Glutathione Peroxidase / Q000187:drug effects; D007273:Injections, Intramuscular / Q000662:veterinary; D012643:Selenium / Q000008:administration & dosage* / Q000172:deficiency* / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium