Renal synthesis of prostaglandins and thromboxane has no causative role for protein-induced glomerular hyperfiltration in healthy humans.
The study was devised to establish the role of prostaglandin E2, prostaglandin1 alpha and thromboxane A2 in the genesis of glomerular hyperfiltration response to a meat meal in healthy humans. To this end, a group of 8 healthy women was studied 4 times: in the control state (study 1), after a meat meal (study 2), following a meat meal associated with intravenous aspirin (study 3) and finally after a meat meal associated with intravenous aspirin following 2-day pretreatment with oral aspirin (study 4). Urinary excretion of prostaglandins and thromboxane increased during the glomerular hyperfiltration response to a meat meal and was suppressed by aspirin administration which did not suppress the renal hemodynamic response to the meat meal. The data do not support a causal role for prostaglandins and thromboxane A2 in the hemodynamic response to acute protein loading.
DeSanto
N G
NG
Chair of Nephrology, University of Naples, Italy.
Calò
L
L
Anastasio
P
P
Coppola
S
S
Cantaro
S
S
Favaro
S
S
Capasso
G
G
Borsatti
A
A
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D015232:Dinoprostone / Q000096:biosynthesis; D004435:Eating; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000502:physiology*; D008460:Meat; D011453:Prostaglandins / Q000096:biosynthesis* / Q000502:physiology; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000502:physiology; D013997:Time Factors
D004044:Dietary Proteins; D011453:Prostaglandins; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone; D001241:Aspirin