[The presynaptic metabolic modulation of the impulse-dependent release of 3H-serotonin from rat brain slices by ipsapirone (TVX Q 7821) and other serotonin agonists].
The experiments with thin slices of the cortex and dorsal raphe nucleus of rat midbrain which were incubated with [3H]-hydroxytryptamine ([3H-]HT) have established that serotonin and its agonists inhibit 3H-HT release from the electrically stimulated slices. The serotonin agonists ipsapirone (TVX Q 7821), buspirone, gepirone, and 8-OH-DPAT which mainly stimulate the Type 1A serotonin receptors of somatodendritic synapses inhibit the release of [3H]-HT from the dorsal raphe nucleus slices to a greater extent rather from those of the cortex. On the contrary, the serotonin agonists TFMPP, mCPP, and Ru 24969 which predominantly affect 1B-HT receptors largely inhibit [3H]-HT release from the electrically stimulated cortical slices. Ipsapirone-induced inhibition of the impulse-dependent release of [3H]-HT has been found to be associated with changes in intracellular cAMP levels and protein kinase activity. The nature of serotonin agonist-induced modulation of the impulse-dependent release of [3H]-HT from serotoninergic neurons is discussed in the paper.
Dolzhenko
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AT
Traber
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Glaser
T
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De Vry
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003864:Depression, Chemical; D004558:Electric Stimulation; D066298:In Vitro Techniques; D011743:Pyrimidines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014316:Tritium
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D017981:Receptors, Neurotransmitter; D017366:Serotonin Receptor Agonists; D014316:Tritium; D012701:Serotonin; C043077:ipsapirone
Presinapticheskaia metabolicheskaia moduliatsiia impul'snogo vysvobozhdeniia 3H-serotonina srezami mozga krys ipsapironom (TVX Q 7821) i drugimi agonistami serotonina.