Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.
Bertilsson
L
L
Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden.
Dahl
M L
ML
Ekqvist
B
B
Llerena
A
A
D014150:Antipsychotic Agents / Q000378:metabolism*; D003006:Clopenthixol / Q000378:metabolism; D003647:Debrisoquin / Q000378:metabolism*; D006220:Haloperidol / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D010546:Perphenazine / Q000378:metabolism; D011110:Polymorphism, Genetic
D014150:Antipsychotic Agents; D003006:Clopenthixol; D010546:Perphenazine; D006220:Haloperidol; D003647:Debrisoquin