title: Transitional cell carcinoma of fossa navicularis in a man with three other synchronous malignancies.
abstract: Transitional cell carcinoma arising from the anterior portion of the male urethra is rare, with less than 10 cases reported in the literature. Our patient had a high-grade, highly invasive transitional cell carcinoma originating in the fossa navicularis and extending proximally along the corpus spongiosum, the corpora cavernosa, and blood and lymphatic vessels. In addition, the patient had a concurrent low-grade prostatic adenocarcinoma, a large basal cell carcinoma of the nose, and a squamous cell carcinoma of the penile skin. The previously reported cases are reviewed, with particular reference to the possible association of these tumors with human papillomavirus infection.
authors.affiliation: Department of Pathology, Veterans Affairs Medical Center, Houston, Texas.
authors.forename: R M
authors.initials: RM
authors.lastname: Genta
authors.forename: M A
authors.initials: MA
authors.lastname: Rosen
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000473:pathology*; D010412:Penile Neoplasms / Q000473:pathology*; D010413:Penis / Q000473:pathology; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D014521:Urethra / Q000473:pathology; D014523:Urethral Neoplasms / Q000473:pathology*