title: The influence of triazolam and flunitrazepam on isokinetic and isometric muscle performance.
abstract: The influences of two benzodiazepines (triazolam 0.25 mg and flunitrazepam 2 mg) on isokinetic and isometric muscle performance and on cardiovascular parameters were examined after a standard period of sleep. A randomized and double-blind test procedure was used (n = 15). Triazolam had no significant (p < 0.05) influence on either of the test conditions. Administration of flunitrazepam significantly lowered values for maximal isometric force and for the cardiovascular parameters. It was concluded that triazolam does not influence performance. On the other hand, flunitrazepam does influence a number of strength characteristics and cardiovascular parameters in effort situations.
authors.affiliation: Free University of Brussels, Department of Experimental Anatomy, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Zinzen
authors.forename: J P
authors.initials: JP
authors.lastname: Clarijs
authors.forename: J
authors.initials: J
authors.lastname: Cabri
authors.forename: D
authors.initials: D
authors.lastname: Vanderstappen
authors.forename: T J
authors.initials: TJ
authors.lastname: Van den Berg
mesh_terms: D000328:Adult; D004300:Doping in Sports; D004311:Double-Blind Method; D016552:Ergometry; D005445:Flunitrazepam / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D014229:Triazolam / Q000494:pharmacology*
chemical_list: D014229:Triazolam; D005445:Flunitrazepam