title: Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.
abstract: Eight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.
authors.affiliation: Department of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.
authors.forename: A L
authors.initials: AL
authors.lastname: Hartley
authors.forename: J M
authors.initials: JM
authors.lastname: Birch
authors.forename: V
authors.initials: V
authors.lastname: Blair
authors.forename: P M
authors.initials: PM
authors.lastname: Jones
authors.forename: H R
authors.initials: HR
authors.lastname: Gattamaneni
authors.forename: A M
authors.initials: AM
authors.lastname: Kelsey
mesh_terms: D000293:Adolescent; D002277:Carcinoma; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000235:genetics / Q000628:therapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D012306:Risk; D009396:Wilms Tumor