[Preparation of monoclonal antibodies against ovarian carcinoma bearing chemical drugs entrapped in liposomes and the cytotoxic tests to carcinoma cells].
Monoclonal antibodies COC166-9 were prepared bearing adriamycin and cis-Platinum entrapped in liposomes respectively as chemoimmunoliposomes MLA and MLP. In vitro growth inhibition of SKOV3 ovarian carcinoma cell lines were tested by MLA and MLP. The results showed that MLA had the same cytotoxic effects as single adriamycin (ADM) in high concentration. However MLA was much stronger than ADM if in low concentration. There was no difference between MLP and single cis-Platinum, of which neither were sensitive to SKOV3 cells.
Li
W J
WJ
People's Hospital, Beijing Medical University.
D000911:Antibodies, Monoclonal; D002945:Cisplatin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology*; D008081:Liposomes; D010051:Ovarian Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D008081:Liposomes; D004317:Doxorubicin; D002945:Cisplatin