title: [Parameters of thyroid status in children and adolescents living in one of the Kaluga regions contaminated with radionuclides].
abstract: Thyroid status was examined in 1214 children living in the Ulyanov district of the Kaluga region contaminated with radionuclides. Thyroid size and structure were assessed using ultrasonic examination, its function was characterized based on thyrotropin and free thyroxin measurements. Specific autoimmunity was evaluated from assays of antibodies to microsomal antigen and thyroglobulin. The resultant values were assessed with due consideration for the individual dose of 131I absorbed by the thyroid. Thyroid enlargement was detected in 21.2%, nodular goiter in 0.79% of the examinees. A reliable positive correlation was found between the degree of thyroid enlargement and 131I absorbed dose. Functional parameters (thyrotropin and free thyroxin) were within the normal range, no correlation was detected between hormonal parameters, thyroid size, and 131I absorbed dose. Antibodies to microsomal antigen were detected in 4.3%, to thyroglobulin in 7.2%, to both in 2.8% of the examinees, this being within the normal range in the population; but a relationship was detected between antibody production and absorbed dose of 131I. Hence, though no noticeable changes in the thyroid status were detected 5 years after the accident in the population examined, the revealed correlations between thyroid enlargement, presence of antithyroid antibodies, and 131I dose may be indicative of a possible growth of thyroid morbidity.
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
authors.forename: A F
authors.initials: AF
authors.lastname: Tsyb
authors.forename: E G
authors.initials: EG
authors.lastname: Matveenko
authors.forename: N V
authors.initials: NV
authors.lastname: Omel'chenko
authors.forename: M P
authors.initials: MP
authors.lastname: Borovikova
authors.forename: V A
authors.initials: VA
authors.lastname: Peterkova
authors.forename: A N
authors.initials: AN
authors.lastname: Tiul'pakov
authors.forename: V I
authors.initials: VI
authors.lastname: Kandror
authors.forename: N P
authors.initials: NP
authors.lastname: Goncharov
authors.forename: V S
authors.initials: VS
authors.lastname: Parshin
mesh_terms: D000059:Accidents; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004782:Environmental Health; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D009688:Nuclear Reactors; D011848:Radioactive Pollutants / Q000009:adverse effects*; D012426:Russia; D013961:Thyroid Gland / Q000473:pathology* / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014455:Ukraine
chemical_list: D007457:Iodine Radioisotopes; D011848:Radioactive Pollutants; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Nekotorye pokazateli, kharakterizuiushchie sostoianie shchitovidnoĭ zhelezy u deteĭ i podrostkov, prozhivaiushchikh v odnom iz zagriaznennykh radionuklidami raĭonov Kaluzhskoĭ oblasti.