title: Omental-mesenteric inflammatory pseudotumor. Cytogenetic demonstration of genetic changes and monoclonality in one tumor.
abstract: BACKGROUND
  Extrapulmonary inflammatory pseudotumor (plasma cell granuloma) is an uncommon lesion in adults and children, and little is known either of its etiology or clinical characteristics. However, it remains a significant source of morbidity to patients and confusion to clinicians.
  
  
  METHODS
  Case reports are presented of three patients with intraabdominal inflammatory pseudotumor who recently underwent surgery. A review of the recent world literature is also presented. Clinical and laboratory characteristics of omental-mesenteric inflammatory pseudotumor are reviewed along with a discussion of its etiology.
  
  
  RESULTS
  Cytogenetic data from cells of one patient show a derivative chromosome evolved from a translocation between the long arm of chromosome 2 and the short arm of chromosome 9 [(2;9)(q1,3;p2,2)].
  
  
  CONCLUSIONS
  The lesion is monoclonal, and genetic changes may play a crucial role in the development of this neoplasm. Omental-mesenteric inflammatory pseudotumor appears to represent a distinct clinicopathologic entity as a benign neoplasm in children.
authors.affiliation: Department of General Surgery, Isaac Walton Killam Children's Hospital, Halifax, Nova Scotia, Canada.
authors.forename: S P
authors.initials: SP
authors.lastname: Treissman
authors.forename: D A
authors.initials: DA
authors.lastname: Gillis
authors.forename: C L
authors.initials: CL
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Giacomantonio
authors.forename: L
authors.initials: L
authors.lastname: Resch
mesh_terms: D002675:Child, Preschool; D002889:Chromosomes, Human, Pair 2; D002899:Chromosomes, Human, Pair 9; D006104:Granuloma, Plasma Cell / Q000235:genetics*; D006801:Humans; D007249:Inflammation; D007621:Karyotyping; D008297:Male; D008643:Mesentery; D009852:Omentum; D010532:Peritoneal Diseases / Q000235:genetics*; D014178:Translocation, Genetic