Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon.
The susceptibility to alpha/beta interferon (IFN-alpha/beta) or to gamma interferon (IFN-gamma) of various lymphocytic choriomeningitis virus (LCMV) strains was evaluated in C57BL/6 mice and in various cell lines. Anti-IFN-gamma treatment in vivo revealed that the LCMV strains Armstrong, Aggressive, and WE were most susceptible to IFN-gamma whereas Traub, Cl 13-Armstrong, and Docile were resistant. The same pattern of susceptibility to recombinant IFN-gamma was observed in vitro. In vivo treatment with anti-IFN-alpha/beta showed a sizeable increase in replication of Aggressive, Armstrong, and WE; effects were less pronounced for Docile, Cl 13-Armstrong, or Traub. Correspondingly, WE, Armstrong, and Aggressive were all relatively sensitive to purified IFN-alpha/beta in vitro, and Cl 13-Armstrong, Docile, and Traub were more resistant. Overall, there was a good correlation between the capacity of LCMV strains to establish a persistent infection in adult immunocompetent mice and their relative resistance to IFN-gamma and IFN-alpha/beta.
Moskophidis
D
D
Institute of Experimental Immunology, University of Zurich, Switzerland.
Battegay
M
M
Bruendler
M A
MA
Laine
E
E
Gresser
I
I
Zinkernagel
R M
RM
D000818:Animals; D002460:Cell Line; D004352:Drug Resistance, Microbial; D005347:Fibroblasts / Q000382:microbiology; D016898:Interferon-alpha / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D008217:Lymphocytic choriomeningitis virus / Q000187:drug effects*; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
D016898:Interferon-alpha; D016899:Interferon-beta; D007371:Interferon-gamma