title: New polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) not linked to schizophrenia in five Canadian pedigrees.
abstract: A new HincII polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) is reported. In light of evidence indicating possible dysfunction of the 5-HT neurotransmitter system in schizophrenia, this new 5-HT receptor polymorphism was tested for linkage to schizophrenia in 5 Canadian pedigrees. Although 1 of the 5 pedigrees tested had a slightly positive lod score, there was no evidence overall for linkage to schizophrenia under dominant, recessive, or two locus models.
authors.affiliation: Section of Neurogenetics, Laboratories of the Clarke Institute of Psychiatry, Toronto, Ont., Canada.
authors.forename: D G
authors.initials: DG
authors.lastname: Sidenberg
authors.forename: A S
authors.initials: AS
authors.lastname: Bassett
authors.forename: L
authors.initials: L
authors.lastname: Demchyshyn
authors.forename: H B
authors.initials: HB
authors.lastname: Niznik
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: A B
authors.initials: AB
authors.lastname: Kamble
authors.forename: W G
authors.initials: WG
authors.lastname: Honer
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D002170:Canada; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D011985:Receptors, Serotonin