[Immunophenotypic study of acute myeloid leukemia (AML): biological significance and prognostic implications].
The immunophenotype of 61 de novo AML referring to the Institute of Hematology of Ferrara between January 1988 and September 1992 was studied in order to evaluate the prognostic impact and the biological implications of this approach. In this study we confirm the possible aberrant expression of some antigens and the lack of a strict correlation between FAB classification and immunophenotype. The expression of the CD14 and CD34 was correlated with a worse prognosis, while the CD34+ patients further showed a lower probability to achieve a complete remission.
Rigolin
G M
GM
Istituto di Ematologia, Università di Ferrara.
Latorraca
A
A
Moretti
S
S
Previati
R
R
Lanza
F
F
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor
Studio immunofenotipico nelle leucemie acute mieloidi (LMA): significato biologico ed implicazioni prognostiche.