title: A comparative analysis of management and prognosis in stage I and II fallopian tube carcinoma and epithelial ovarian cancer.
abstract: Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 with OC, in stage I and II were included into this study. A univariate as well as a multivariate analysis for survival was performed, including factors such as age, histological type, grading and surgical and adjuvant treatment. A significantly poorer outcome (P = 0.0002) for FTC patients with a 5-year survival of 50.8% compared with 77.5% for OC patients was observed. This finding was persistent and independent of any investigated factor, in univariate as well as multivariate analyses. Therefore, we feel that a more aggressive therapeutic approach to the treatment of FTC even in early stages can be recommended. On the other hand, the retrospective character of our study has to be taken into account.
authors.affiliation: Department of Obstetrics and Gynecology, SMZ-Ost, Vienna, Austria.
authors.forename: A C
authors.initials: AC
authors.lastname: Rosen
authors.forename: P
authors.initials: P
authors.lastname: Sevelda
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: A H
authors.initials: AH
authors.lastname: Graf
authors.forename: M
authors.initials: M
authors.lastname: Lahousen
authors.forename: A
authors.initials: A
authors.lastname: Reiner
authors.forename: L
authors.initials: L
authors.lastname: Auerbach
authors.forename: N
authors.initials: N
authors.lastname: Vavra
authors.forename: H R
authors.initials: HR
authors.lastname: Rosen
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D005185:Fallopian Tube Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D011336:Probability; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome