title: Intratracheal pulmonary ventilation (ITPV): control of positive end-expiratory pressure at the level of the carina through the use of a novel ITPV catheter design.
abstract: A new mode of pulmonary ventilation called intratracheal pulmonary ventilation (ITPV) was studied. Briefly, a continuous flow of air/oxygen is introduced through a small catheter, the tip of which is positioned at the carina, with a diffuser mounted at its distal end. A timed expiration valve, when closed, provides for inspiration; when open, it provides for expiration. The system as first described had a potential for significant back pressure at the level of the carina, which was more at rapid gas flows and with smaller endotracheal tubes. We have now mounted a venturi on the tip of the catheter (reverse thrust catheter [RTC]) that avoids back pressure, and which facilitates expiration. At respiratory rates from 10 to 120/min, the ITPV system with the RTC maintained end-expiratory pressure at the level of the carina at, or near 0 cm H2O. Compared to conventional mechanical ventilation, at identical respiratory rates, this system reduced tidal volume by one half at the lowest respiratory rates, and by as much as two thirds at the highest respiratory rates, with a proportional decrease in peak inspiratory pressure. ITPV has the smallest minute volume ventilation of any conventional or nonconventional mode of pulmonary ventilation.
authors.affiliation: Pulmonary and Cardiac Assist Devices Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: T
authors.initials: T
authors.lastname: Kolobow
authors.forename: T
authors.initials: T
authors.lastname: Powers
authors.forename: S
authors.initials: S
authors.lastname: Mandava
authors.forename: M
authors.initials: M
authors.lastname: Aprigliano
authors.forename: A
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: K
authors.initials: K
authors.lastname: Tsuno
authors.forename: E
authors.initials: E
authors.lastname: Mueller
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation*; D011175:Positive-Pressure Respiration / Q000295:instrumentation / Q000379:methods*; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods*; D012756:Sheep