title: Comparison of different bolus doses of morphine for patient-controlled analgesia in children.
abstract: Forty children undergoing appendicectomy were allocated randomly to receive one of two PCA regimens with morphine. Group B10 received bolus doses of 10 micrograms kg-1 and group B20 received bolus doses of 20 micrograms kg-1. In both groups there was a lockout interval of 5 min and a background infusion of 4 micrograms kg-1 h-1. Group B20 self-administered considerably more morphine (P < 0.01) than group B10. There was no difference between the pain scores of the groups at rest. Group B20 had significantly (P < 0.05) smaller pain scores during movement than group B10 and the latter group suffered significantly (P < 0.01) more hypoxaemic episodes than group B20. There were no differences between the groups in the incidence of vomiting, excess sedation or the amount of time spent asleep at night.
authors.affiliation: Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill, Glasgow.
authors.forename: E
authors.initials: E
authors.lastname: Doyle
authors.forename: K J
authors.initials: KJ
authors.lastname: Mottart
authors.forename: C
authors.initials: C
authors.lastname: Marshall
authors.forename: N S
authors.initials: NS
authors.lastname: Morton
mesh_terms: D000293:Adolescent; D016058:Analgesia, Patient-Controlled; D001062:Appendectomy; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009325:Nausea / Q000139:chemically induced; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
chemical_list: D009020:Morphine