title: [Intractable bacterial infection--review].
abstract: The factors involved in the mechanism of intractable bacterial infections are systemic, local and iatrogenic compromised conditions which mean the deficiency of host defence. From our results, especially on diffuse panbronchiolitis with Pseudomonas aeruginosa, we have learned about the harmful effects of destroyed neutrophils accumulated in bronchial and bronchiolar trees. Although low doses of erythromycin therapy is effective for intractable DPB. There are many evidences on the mechanisms for this treatment reported by Japanese researchers. We also reported our data of IL-8 level in BALF after this treatment. Bacterial factors of intractable processes are also important.
authors.affiliation: Department of Internal Medicine, Nagasaki University.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Nagatake
authors.forename: K
authors.initials: K
authors.lastname: Oishi
authors.forename: A
authors.initials: A
authors.lastname: Kamrudin
mesh_terms: D001980:Bronchi / Q000166:cytology; D001988:Bronchiolitis / Q000188:drug therapy / Q000382:microbiology*; D004917:Erythromycin / Q000008:administration & dosage; D006801:Humans; D016867:Immunocompromised Host; D009504:Neutrophils; D011552:Pseudomonas Infections
chemical_list: D004917:Erythromycin