Interleukin-6 does not activate protein breakdown in rat skeletal muscle.
The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein synthesis or that of alpha-(methyl)-aminoisobutyric acid (MeAIB) uptake by the muscle preparations. It is concluded that IL-6 is not the mediator in activating muscle protein turnover during sepsis in the rat.
García-Martínez
C
C
Department de Bioquimica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
López-Soriano
F J
FJ
Argilés
J M
JM
D000818:Animals; D005260:Female; D015850:Interleukin-6 / Q000494:pharmacology* / Q000502:physiology; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D015850:Interleukin-6; D009124:Muscle Proteins; D009584:Nitrogen