Reversal of inherent multidrug-resistance in primary human renal cell carcinoma cell cultures by S 9788.
In a panel of 14 primary cultures of human renal cell carcinomas the reversal of inherent multidrug-resistance by S 9788, a new triazinoaminopiperidine derivative, was analysed. In combination with doxorubicin S 9788 revealed an evident reversal of multidrug resistance in 12 cell cultures. Two cell cultures remained unaffected. An association between reversal and P-glycoprotein (P-170) expression suggests that S 9788 exerts its activity through P-glycoprotein.
Efferth
T
T
German Cancer Research Center, Heidelberg.
Dunn
T A
TA
Berlion
M
M
Langenbahn
H
H
Pommerenke
E W
EW
Volm
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002292:Carcinoma, Renal Cell; D002352:Carrier Proteins / Q000032:analysis* / Q000096:biosynthesis; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000633:toxicity*; D004347:Drug Interactions; D004351:Drug Resistance / Q000502:physiology*; D006801:Humans; D007680:Kidney Neoplasms; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000096:biosynthesis; D051379:Mice; D010880:Piperidines / Q000633:toxicity*; D012510:Sarcoma 180; D014227:Triazines / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D010880:Piperidines; D014227:Triazines; C077022:S 9788; D004317:Doxorubicin