[The role of oxygen radicals in adult respiratory distress syndrome].
A traumatic adult respiratory distress syndrome (ARDS) model was made with 3 intravenous bolus of homologous bone marrow extract in rabbits. Variables were then measured including the metabolites of oxygen radicals in plasma and expired gases, serum lactic dehydrogenase (LDH) isoenzymes and plasma fibronectin (Fn). A two peak increase was found in expired ethane and plasma conjugated dienes following decrease of periphery white blood and polymorphonuclear neutrophil (PMN) differential count; continuous increase of serum LDH3 and severe descent of plasma Fn were also found after the trauma. The above results suggest that PMN releasing oxygen radicals play an important role in RDS pathogenesis; and expired ethane, circulating conjugated dienes, LDH3 and Fn may be useful for making diagnosis and prognosis assessment of ARDS.
Chen
Z T
ZT
Respiratory Disease Centre, Xin Qiao Hospital, Third Military Medical University of PLA, Chongqing.
Mao
B L
BL
Gou
J
J
D000818:Animals; D004195:Disease Models, Animal; D005353:Fibronectins / Q000097:blood*; D005609:Free Radicals; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008054:Lipid Peroxides / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011817:Rabbits; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000378:metabolism
D005353:Fibronectins; D005609:Free Radicals; D007527:Isoenzymes; D008054:Lipid Peroxides; D007770:L-Lactate Dehydrogenase; D010100:Oxygen