title: [The pharmacokinetic and biopharmaceutical evaluation of the new tranquilizer gidazepam].
abstract: The pharmacokinetics of the new tranquilizer gidazepam and its desalkyl metabolite was studied in rats. Some biopharmaceutical characteristics of the agents under study were defined. Gidazepam was found to have much advantage over the principal active ingredient (desalkylgidazepam) in its higher bioavailability. The methodological approaches developed by the authors to evaluate the efficacy of gidazepam may be applied in designing novel drugs.
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Kruchenkov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: S G
authors.initials: SG
authors.lastname: Otabekova
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000737:chemistry / Q000493:pharmacokinetics*; D001702:Biopharmaceutics; D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D011355:Prodrugs / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011355:Prodrugs; D001569:Benzodiazepines; C077010:gidazepam
vernacular_title: Farmakokineticheskaia i biofarmatsevticheskaia otsenka novogo trankvilizatora gidazepama.