title: Prenatal diagnosis of an extranumerary i(22p) with normal phenotype.
abstract: A DA-Dapi and AgNOR-negative extranumerary chromosome was identified prenatally in a male fetus and also found in his normal father. Fluorescence in situ hybridization using repetitive DNA probes showed that the minute marker was positive at both ends for beta-satellite sequences, while its centromere was recognized by a 22 alphoid probe. It is concluded that the non-mosaic familial marker represents a 22p isochromosome.
authors.affiliation: Dept of Biology and Genetics, Medical Faculty, University of Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Doneda
authors.forename: L
authors.initials: L
authors.lastname: Dalprà
authors.forename: M G
authors.initials: MG
authors.lastname: Tibiletti
authors.forename: L
authors.initials: L
authors.lastname: Larizza
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics*; D025063:Chromosome Disorders; D002892:Chromosomes, Human, Pair 22; D005190:Family; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D010641:Phenotype; D011247:Pregnancy; D011296:Prenatal Diagnosis