title: Successful treatment for a metastatic supratentorial malignant rhabdoid tumor.
abstract: The case of a boy with a familial history of Rendu-Osler disease, who successively developed a cerebellar pilocytic astrocytoma (at 3 years of age) and a metastatic supratentorial malignant rhabdoid tumor (at the age of 12 years) is reported. After a complete surgical removal, the CSF was cleared by 4 courses of chemotherapy, and the child received a craniospinal irradiation. He is currently alive and well 19 months after completion of the treatment. The authors discuss the ethiopathogeny of such intracranial tumors and argue for aggressive treatment.
authors.affiliation: Pediatric Unit, Centre Léon Bérard, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: D
authors.initials: D
authors.lastname: Dolbeau
authors.forename: H
authors.initials: H
authors.lastname: Sobol
authors.forename: A
authors.initials: A
authors.lastname: Jouvet
authors.forename: C
authors.initials: C
authors.lastname: Carrie
authors.forename: C
authors.initials: C
authors.lastname: Pondarre
authors.forename: M
authors.initials: M
authors.lastname: Brunat-Mentigny
authors.forename: T
authors.initials: T
authors.lastname: Philip
authors.forename: C
authors.initials: C
authors.lastname: Mottolese
mesh_terms: D001254:Astrocytoma / Q000601:surgery; D002528:Cerebellar Neoplasms / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000628:therapy*; D010375:Pedigree; D018335:Rhabdoid Tumor / Q000556:secondary / Q000628:therapy*; D015173:Supratentorial Neoplasms / Q000556:secondary / Q000628:therapy*