A comparative study of enzymuria, in the rat, of the drug combinations amikacin/vancomycin and amikacin/teicoplanin.
The aim of this study was to compare nephrotoxicity of the combinations amikacin/vancomycin and amikacin/teicoplanin. Eighteen male Wistar rats were divided into 3 groups of 6 animals each. The first group received 50 mg.kg-1 of amikacin (i.m. route) and 100 mg.kg-1 of vancomycin (i.p. route). The second group received 50 mg.kg-1 of amikacin (i.m. route) and 40 mg.kg-1 of teicoplanin (i.p. route). The third group received an isotonic solution of sodium chloride. The antibiotics were injected for a period of 6 days. Urine samples of animals were taken 24 h before the beginning of the experiment, then every day, throughout the duration of the treatment (6 days), continuing for an additional 3 days following completion of the administration of the drugs. There were no significant modifications in the urinary excretions of alanine aminopeptidase and the creatinine between the 3 groups; but in the group receiving amikacin/teicoplanin, we observed between days 3 and 8 an increase in the excretion of N-acetyl-beta-D- glucosaminidase when compared to the group receiving amikacin/vancomycin (p < or = 0.05) and to the control group (p < or = 0.01).
Fauconneau
B
B
Institut d'Etudes des Xénobiotiques Poitiers, France.
Pariat
C
C
Bouquet
S
S
Piriou
A
A
Ingrand
P
P
Courtois
P
P
D000118:Acetylglucosaminidase / Q000652:urine*; D000583:Amikacin / Q000008:administration & dosage / Q000633:toxicity; D000626:Aminopeptidases / Q000652:urine*; D000818:Animals; D018826:CD13 Antigens; D004359:Drug Therapy, Combination / Q000633:toxicity*; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017334:Teicoplanin / Q000008:administration & dosage / Q000633:toxicity; D014640:Vancomycin / Q000008:administration & dosage / Q000633:toxicity
D017334:Teicoplanin; D014640:Vancomycin; D000583:Amikacin; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens