[Clinical significance of preoperative serum IAP levels in patients with gastric cancer].
We investigated the relationship between preoperative serum IAP levels and lymphocyte subsets in 81 gastric cancer patients to clarify the clinical significance of serum IAP level of cancer host. In the two groups divided by cut-off point of serum IAP 580 micrograms/ml, the percentage of CD4+ cells and CD4+/CD8+ ratio of the high IAP group was significantly lower than that of the low group and the percentage of CD11b+ cells and CD25+ cells of the high IAP group was significantly higher than that of the low group. There was positive correlation between the IAP levels and CD11b+ cells, CD25+ cells. These results suggest that BRM therapy will be more effective in the low IAP group. Assaying of serum IAP is thought to be useful as immunological parameter in BRM therapy for cancer patients.
Kohno
K
K
First Department of Surgery, Yamanashi Medical College.
Sekikawa
T
T
Ogawara
T
T
Matsumoto
Y
Y
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D018845:CD11 Antigens; D015704:CD4 Antigens / Q000097:blood; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000097:blood; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013274:Stomach Neoplasms / Q000097:blood* / Q000276:immunology / Q000628:therapy; D016176:T-Lymphocyte Subsets
D015703:Antigens, CD; D018845:CD11 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D007155:Immunologic Factors; D009363:Neoplasm Proteins; D015375:Receptors, Interleukin-2; C030193:immunosuppressive acidic protein