title: Digoxin toxicity. Recognizing the varied visual presentations.
abstract: We report three cases of digoxin toxicity presenting with decreased visual acuity, unaccompanied by the classic visual symptom of xanthopsia. Visual function improved and symptoms diminished upon lowering of blood digoxin level. Electroretinographic (ERG) abnormalities in the first case were suggestive of a cone deficit, which supports recent electrodiagnostic and labeled tracer studies implicating retinal dysfunction in the pathogenesis of digoxin toxicity. The second patient presented with visual symptoms exclusively. Evaluation of the third case was hampered by advanced retinitis pigmentosa and the presentation was complicated by a syncopal episode. Digoxin toxicity is a potentially life-threatening condition. Ophthalmologists and neurologists may be the first physicians consulted. It must be considered in the differential diagnosis in patients with otherwise unexplained visual loss.
authors.affiliation: Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: J R
authors.initials: JR
authors.lastname: Piltz
authors.forename: C
authors.initials: C
authors.lastname: Wertenbaker
authors.forename: S E
authors.initials: SE
authors.lastname: Lance
authors.forename: T
authors.initials: T
authors.lastname: Slamovits
authors.forename: H F
authors.initials: HF
authors.lastname: Leeper
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003623:Dark Adaptation; D004077:Digoxin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D006801:Humans; D008027:Light; D008875:Middle Aged; D014786:Vision Disorders / Q000139:chemically induced / Q000175:diagnosis*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D004077:Digoxin