A possible interpretation for a wide range of resting membrane potentials in human term placental cells.
Membrane potentials of human term placental cells ranged from 0 mV to -85 mV with two peaks. Two different conductances were recognized. One is the inwardly rectifying K conductance which was responsible for one peak at -75 mV. The other one was the outwardly rectifying conductance which was responsible for another peak at -10 mV. The outwardly rectifying current was suggested to be carried mainly by Cl ions because of the reversal potential and a sensitivity to a Cl channel blocker (DIDS). Membrane potentials in human term placental cells were suggested to range between K and Cl equilibrium potentials.
Yamamoto
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Ste-Justine Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Montreal, Quebec, Canada.
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D002478:Cells, Cultured; D004553:Electric Conductivity; D005260:Female; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D010920:Placenta / Q000166:cytology / Q000502:physiology*; D011247:Pregnancy
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid