title: Unrelatedness of multiply resistant Staphylococcus aureus with resistance to methicillin and to quinolones (QR-MRSA) as evident from SmaI-digestion patterns of genomic DNA.
abstract: Methicillin-resistant S. aureus with quinolone-resistance (QR-MRSA) isolated in Germany from three outbreaks of nosocomial infections and from sporadic nosocomial infections in five hospitals exhibited different SmaI-restriction patterns of their genomic DNA. Phage-typing and determination of plasmid profiles performed in parallel confirmed this differentiation, with one exception. These results indicate that there is obviously no overregional spread of one particular QR-MRSA clone and that quinolone resistance has developed independently in different MRSA.
authors.affiliation: Robert Koch-Institute, Federal Health Office, Wernigerode, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Witte
authors.forename: C
authors.initials: C
authors.lastname: Cuny
authors.forename: H
authors.initials: H
authors.lastname: Claus
mesh_terms: D015373:Bacterial Typing Techniques; D003428:Cross Infection / Q000382:microbiology; D004269:DNA, Bacterial; D004352:Drug Resistance, Microbial / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D016106:Methicillin Resistance / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D015363:Quinolones / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D004269:DNA, Bacterial; D015363:Quinolones