title: Follow-up of patients with colorectal cancer. A meta-analysis.
abstract: OBJECTIVE
  The authors sought to determine whether intensive follow-up improves 5-year survival rates in patients with colorectal cancer who were operated on for cure.
  
  
  BACKGROUND
  Intensive follow-up of patients with colorectal cancer is still controversial. The present uncertainty in regard to the value of intensive follow-up could be the result of the absence of prospective randomized studies comparing patients with and without follow-up.
  
  
  METHODS
  Studies comparing two follow-up programs of different intensities were identified in the medical literature and were aggregated in a meta-analysis using the "random effects method." Seven nonrandomized studies describing 3283 patients were analyzed.
  
  
  RESULTS
  Patients with intensive follow-up did have 9% better 5-year survival rates than did those with minimal or no follow-up, only when intensive follow-up included carcinoembryonic antigen (CEA) assays. In addition, more asymptomatic recurrences were detected and more recurrences were resected in patients with intensive follow-up.
  
  
  CONCLUSIONS
  This meta-analysis indicated that intensive follow-up using CEA assays can identify treatable recurrences at a relatively early stage. Treatment of these recurrences appears to be associated with improved 5-year survival rates. However, not all intensive follow-up strategies will be equally effective. Follow-up may yield the best results if diagnostic tests are used only to detect those recurrences that can be operated on with curative intent and when follow-up is "individualized," according to patient characteristics.
authors.affiliation: Medical Decision Making Unit, University of Leiden, The Netherlands.
authors.forename: D J
authors.initials: DJ
authors.lastname: Bruinvels
authors.forename: A M
authors.initials: AM
authors.lastname: Stiggelbout
authors.forename: J
authors.initials: J
authors.lastname: Kievit
authors.forename: H C
authors.initials: HC
authors.lastname: van Houwelingen
authors.forename: J D
authors.initials: JD
authors.lastname: Habbema
authors.forename: C J
authors.initials: CJ
authors.lastname: van de Velde
mesh_terms: D000206:Actuarial Analysis; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D015996:Survival Rate