title: Prevention of postoperative nausea and vomiting with transdermal hyoscine in children using patient-controlled analgesia.
abstract: We have studied 40 children aged 6-14 yr undergoing abdominal surgery under general anaesthesia with extradural block; they were allocated randomly to receive transdermal hyoscine (loading dose 140 micrograms, followed by 5 micrograms h-1) or placebo for the duration of postoperative analgesia with PCA morphine. There was a significant (P < 0.001) reduction in the incidence of postoperative nausea and vomiting in the treated group compared with the placebo group during the first 48 h after operation. The treated group also had a significantly increased incidence of sedation (P < 0.02) and dry mouth (P < 0.01).
authors.affiliation: Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill, Glasgow.
authors.forename: E
authors.initials: E
authors.lastname: Doyle
authors.forename: G
authors.initials: G
authors.lastname: Byers
authors.forename: L R
authors.initials: LR
authors.lastname: McNicol
authors.forename: N S
authors.initials: NS
authors.lastname: Morton
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D016058:Analgesia, Patient-Controlled; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009325:Nausea / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012601:Scopolamine / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D014839:Vomiting / Q000517:prevention & control*; D014987:Xerostomia / Q000139:chemically induced
chemical_list: D012601:Scopolamine