title: Restoration of tissue antioxidants and prevention of renal stone deposition in vitamin B6 deficient rats fed with vitamin E or methionine.
abstract: Observed loss in body weight gain, increased lipid peroxidation reaction, decreased concentrations of antioxidants, ascorbic acid, alpha-tocopherol and reduced glutathione and antioxidant enzymes, glutathione peroxidase and catalase and increased concentration of hydroperoxides and hydroxyl radicals in vitamin B6 deficient rat liver [J Nutri Biochem, 2 (1991) 245] and kidney [Biochem International, 21 (1991) 599] were nearly normalized on feeding with vitamin E or methionine. Accumulation of oxalate and calcium during vitamin B6 deficiency was abolished by feeding vitamin E or methionine. Calcium oxalate deposition observed in vitamin B6 deficient kidney was completely prevented when fed along with vitamin E or methionine. However the hyperoxaluria and hypercalciuria persisted even after feeding with vitamin E or methionine.
authors.affiliation: Department of Medical Biochemistry, Dr. A L Mudaliar Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, India.
authors.forename: R
authors.initials: R
authors.lastname: Selvam
authors.forename: V
authors.initials: V
authors.lastname: Ravichandran
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D007669:Kidney Calculi / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D026681:Vitamin B 6 Deficiency / Q000188:drug therapy* / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008715:Methionine