Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase.
Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.
Sandström
T
T
Department of Lung Medicine, University Hospital, Umeå, Sweden.
Bjermer
L
L
Rylander
R
R
D000280:Administration, Inhalation; D000328:Adult; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D004391:Dust / Q000009:adverse effects; D004926:Escherichia coli; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D007958:Leukocyte Count; D008070:Lipopolysaccharides / Q000009:adverse effects*; D008218:Lymphocytosis / Q000209:etiology* / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology
D004391:Dust; D005353:Fibronectins; D008070:Lipopolysaccharides