title: Effects of dietary phytosterols on liver lipids and lipid metabolism enzymes.
abstract: The effects of dietary phytosterols on lipid metabolism have been assessed through determination of liver lipids (sterols and fatty acids) and lipid metabolism enzymes (acetyl-CoA carboxylase, malic enzyme, glucose-6-phosphate dehydrogenase) in rats fed 12 or 24 mg cholesterol a day and 0-96 mg phytosterols. The results indicate that, provided the dietary phytosterol to cholesterol ratio is at least 1 and in the presence of a dietary cholesterol excess, phytosterols do exert a regulatory role through decreases of both acetyl-CoA carboxylase and malic enzyme activities. A ratio of 2 enhances this effect. At the same time, liver fatty acids and cholesterol contents significantly decrease.
authors.affiliation: Centre de Nutrition Humaine, Université de Nancy I, France.
authors.forename: L
authors.initials: L
authors.lastname: Laraki
authors.forename: X
authors.initials: X
authors.lastname: Pelletier
authors.forename: J
authors.initials: J
authors.lastname: Mourot
authors.forename: G
authors.initials: G
authors.lastname: Debry
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004032:Diet; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D006153:Guanosine Diphosphate / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D010840:Phytosterols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013261:Sterols / Q000378:metabolism
chemical_list: D002791:Cholesterol, Dietary; D005227:Fatty Acids; D010840:Phytosterols; D013261:Sterols; D006153:Guanosine Diphosphate; D008291:Malate Dehydrogenase; D000103:Acetyl-CoA Carboxylase