title: [A comparison of two delivery devices on the bronchodilatory effects of procaterol from a metered dose inhaler].
abstract: The bronchodilatory response to procaterol delivery by a metered dose inhaler with a spacer device (Volumatic) and a corniced extension tube was studied in a double blind manner in 18 asthmatic children, who were brought to our emergency room with acute attacks. The mean percent increase in forced expiratory volume in 1 second (FEV1) with the Volumatic was 55.6 +/- 39.3%, and 46.2 +/- 37.4% with the extension tube. There were no significant differences in the mean percent increase in FEV1, forced vital capacity (FVC), maximal flow rate at 50% of vital capacity (V50), maximal flow rate at 25% of vital capacity (V25) and peak expiratory flow rate (PEFR) between the two devices. It is concluded that there is no difference in the bronchodilatory effects of the two devices. The corniced extension tube has the advantage of being less expensive and more convenient to carry around.
authors.affiliation: Second Department of Pediatrics, Toho University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Kishida
authors.forename: H
authors.initials: H
authors.lastname: Uchiyama
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: A
authors.initials: A
authors.lastname: Sasamoto
authors.forename: T
authors.initials: T
authors.lastname: Koshibu
authors.forename: I
authors.initials: I
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Iikura
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D017265:Procaterol / Q000008:administration & dosage*; D013224:Status Asthmaticus / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D001993:Bronchodilator Agents; D017265:Procaterol