title: Hypotension during subarachnoid anaesthesia: haemodynamic analysis of three treatments.
abstract: We have compared three methods of preventing hypotension during subarachnoid anaesthesia. We attempted to maintain systolic arterial pressure (SAP) greater than 75% of baseline by use of i.v. fluids (preloading with normal saline 16 ml kg-1 and, if necessary, three subsequent boluses of 2.5 ml kg-1), an infusion of metaraminol titrated as necessary between 0 and 5 mg h-1 and an infusion of ephedrine titrated as necessary between 0 and 120 mg h-1. SAP and mean arterial pressure (MAP) were measured by automated oscillotonometry, central venous pressure (CVP) by a manometer and cardiac index (CI), stroke index (SI) and heart rate (HR) by transthoracic electrical bioimpedance. Systemic vascular resistance index (SVRI) was derived. Fluids alone failed to maintain SAP in five of 10 patients. Although CI and CVP were maintained, SVRI decreased (25 (SD 15)%; P = 0.02). Metaraminol maintained SAP in all 12 patients. The main cardiovascular change was decreased HR (15 (8)%; P = 0.0001). Ephedrine failed to maintain SAP in two of 12 patients and was accompanied by several cardiovascular changes: HR (21 (12)%; P = 0.001) increased and SI (16 (10)%; P = 0.0001), CVP (3.8 (1.5) cm H2O; P = 0.0001) and SVRI (24 (6)%; P = 0.0001) decreased. Treatment failures resulted from failures to maintain SVRI in the fluid group and CVP and SVRI in the ephedrine group.
authors.affiliation: Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
authors.forename: L A
authors.initials: LA
authors.lastname: Critchley
authors.forename: T G
authors.initials: TG
authors.lastname: Short
authors.forename: T
authors.initials: T
authors.lastname: Gin
mesh_terms: D000368:Aged; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D004809:Ephedrine / Q000627:therapeutic use; D005440:Fluid Therapy; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008680:Metaraminol / Q000627:therapeutic use; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012965:Sodium Chloride / Q000627:therapeutic use; D013599:Systole / Q000187:drug effects
chemical_list: D012965:Sodium Chloride; D008680:Metaraminol; D004809:Ephedrine