[Elevated levels of cytomegalovirus antibodies and increased lymphocyte reactivity in patients with chronic renal failure].
BASELINE: Cytomegaloviral infection is frequently encountered in patients with a reduced immunological reactivity, e.g. during chronic renal insufficiency; these patients have a markedly reduced cellular immunity and various lymphocytic anomalies. One of them is enhanced 3H-thymidine incorporation in non-stimulated lymphocyte cultures. The relationship between lymphocyte reactivity in vitro and activation of cytomegaloviral infection is the subject of the submitted paper.


RESULTS
In 30 patients with chronic renal insufficiency the 3H-thymidine incorporation into lymphocytes and antibodies IgG and IgM against cytomegalovirus and the Epstein-Barr virus were investigated. In 15 patients the 3H-thymidine incorporation into lymphocytes in non-stimulated cultures was elevated, in 15 patients the incorporation was normal. All patients with an elevated 3H-thymidine incorporation the IgG serum levels against cytomegalovirus were markedly higher than in patients with normal incorporation. Serum IgM against cytomegalovirus was present only in patients with an elevated lymphocytic activity. Serum levels of antibodies against the Epstein-Barr virus (IgG) were identical in both groups. None of the patients had IgM against the Epstein-Barr virus.


CONCLUSIONS
Enhanced 3H-thymidine incorporation into lymphocytes in uraemic patients reflects the defect of cellular immunity caused probably by elimination of some immunocompetent lymphocytes.
Korcáková
L
L
Imunologické pracovistĕ Institutu klinické a experimentální medicíny, Praha.
Svobodová
J
J
D000914:Antibodies, Viral / Q000032:analysis*; D003587:Cytomegalovirus / Q000276:immunology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000382:microbiology; D008213:Lymphocyte Activation
D000914:Antibodies, Viral
Zvýsené hladiny protilátek proti cytomegaloviru a zvýsená reaktivita lymfocytů u nemocných s chronickým selháním ledvin.