[The relation of polymorphism of low-density lipoprotein receptor gene with serum cholesterol levels].
PvuII polymorphism of LDL receptor gene and serum lipid levels were analysed in 115 normolipidemic subjects and 57 individuals with hypercholesterolemia. A significant relationship was found between P2 allele and lower serum cholesterol level, suggesting that the LDL receptor may contribute to the variation in cholesterol levels in normolipidemic population. Although the frequency of P2 allele in the Chinese was lower than in westerners, the serum cholesterol levels in the Chinese were not higher or even lower than that in westerners. This might be attributed to the difference in diet, lifestyle or other genes which are related to cholesterol metabolism between the Chinese and westerners.
Fan
L M
LM
Atherosclerosis Research Center, Naj i ng Medical College.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005796:Genes; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011973:Receptors, LDL / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
D011973:Receptors, LDL; D014280:Triglycerides; D002784:Cholesterol