Flumazenil and lignocaine-induced toxicity: is the inverse agonist type activity circadian-time dependent?
We have investigated the possible influence of time of day on the activity of flumazenil on lignocaine-induced toxicity in mice. The circadian pattern of the period of latency for convulsions and the induced mortality for lignocaine alone and for lignocaine plus flumazenil was not statistically significant (cosinor or analysis of variance) but the influence of flumazenil on lignocaine-induced toxicity was circadian-time dependent (F = 27.8, P = 0.0001).
Bruguerolle
B
B
Medical and Clinical Pharmacology Laboratory, Faculty of Medicine, Marseille, France.
Emperaire
N
N
D000818:Animals; D002940:Circadian Rhythm; D004347:Drug Interactions; D005442:Flumazenil / Q000633:toxicity*; D008012:Lidocaine / Q000633:toxicity*; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced
D005442:Flumazenil; D008012:Lidocaine