title: [Chronic active hepatitis and cirrhosis induced by wild germander. 3 cases].
abstract: We report 3 cases of chronic liver injury that were observed after prolonged treatment with wild germander, a herbal medicine recently prohibited by French Ministry of Health, following several reports suggesting its hepatotoxicity. Chronic active hepatitis was found in 2 cases, and active cirrhosis in 1 case. The onset of hepatitis occurred after 6 to 7 months of treatment. Serum anti-nuclear and anti-smooth muscle antibodies were present in 2 patients. In 2 cases, wild-germander involvement was recognized several months after appearance of liver injury. Following treatment discontinuation, outcome was favorable in the 3 patients. These observations suggest that diagnosis of acute or chronic liver injury of unknown origin should always include the search for herbal medicine treatment.
authors.affiliation: Service de Gastroentérologie, Hôpital Farhat, Hached, Sousse, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Ben Yahia
authors.forename: P
authors.initials: P
authors.lastname: Mavier
authors.forename: J M
authors.initials: JM
authors.lastname: Métreau
authors.forename: E S
authors.initials: ES
authors.lastname: Zafrani
authors.forename: M
authors.initials: M
authors.lastname: Fabre
authors.forename: G
authors.initials: G
authors.lastname: Gatineau-Saillant
authors.forename: D
authors.initials: D
authors.lastname: Dhumeaux
authors.forename: A
authors.initials: A
authors.lastname: Mallat
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001628:Beverages / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D056487:Chemical and Drug Induced Liver Injury, Chronic; D003920:Diabetes Mellitus / Q000188:drug therapy; D005260:Female; D005602:France; D006521:Hepatitis, Chronic / Q000097:blood; D006801:Humans; D007880:Legislation, Drug; D008103:Liver Cirrhosis / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects* / Q000627:therapeutic use; D010946:Plants, Medicinal
chemical_list: D010936:Plant Extracts; D000410:Alanine Transaminase
vernacular_title: Hépatite chronique active et cirrhose induites par la germandrée petit-chêne. Trois cas.