title: [Two cases of MERRF (myoclonus epilepsy associated with ragged red fibers) showing different clinical features in the same family].
abstract: A 73-year-old woman (patient 1) developed progressive mental deterioration at age 63, and seizures at age 70. On examination, she showed severe dementia, tonic clonic convulsion, hypotonia and muscular wasting. There was neither myoclonus nor cerebellar ataxia. Brain CT revealed a low density area in the right occipital lobe. A 44-year-old man (son of the patient 1) developed unsteady gait at age 15, muscle twitching at age 18 and then noticed speech disturbance at age 35. He had no history of convulsive seizure. Neurological examination showed cerebellar ataxia, myoclonus in the extremities and mild muscular weakness. His intelligence was normal. Brain CT showed moderate atrophy of the pons and the cerebellum. Both cases showed the same mitochondrial DNA mutation as reported previously in patients with MERRF. However, the clinical features, the age of onset and the brain CT findings were totally different between these 2 cases. In the progress of mitochondrial genetic analysis, atypical forms in MERRF like the patient 1 would increase in number, and the wide variation of clinical symptoms should be considered.
authors.affiliation: Department of Neurology, Hiroshima Red Cross, Atomic Bomb Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Ota
authors.forename: N
authors.initials: N
authors.lastname: Kotake
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D006801:Humans; D017243:MERRF Syndrome / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D004272:DNA, Mitochondrial