[An experimental model of depletion of the blood kallikrein-kinin system].
A new way of kallikrein-kinin system exhaustion in experiments on animals is suggested. This approach consists in a simultaneous rise in the activity of kinin formation and destruction. It is shown that insignificant activation of the kallikrein system and kininase activity leads to activation of the kinin system and rise in active kinin levels. A 1.5-3-fold increase in the total activity of kallikrein and a simultaneous 3-6-fold increase in kininase activity cause exhaustion of the blood kallikrein-kinin system in 2 hours and makes active kinin formation impossible by the body's requirements when the synthesis of kinin system components is maintained.
Shumilov
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D016234:Kallikrein-Kinin System / Q000187:drug effects / Q000502:physiology*; D007610:Kallikreins / Q000032:analysis* / Q000187:drug effects; D007704:Kininogens / Q000097:blood / Q000187:drug effects; D007705:Kinins / Q000097:blood* / Q000187:drug effects; D008297:Male; D010184:Pancreatic Extracts / Q000494:pharmacology; D011205:Povidone / Q000494:pharmacology; D011288:Prekallikrein / Q000032:analysis / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D004338:Drug Combinations; D007704:Kininogens; D007705:Kinins; D010184:Pancreatic Extracts; C019256:pancreatic extract, povidone drug combination; D011288:Prekallikrein; D007610:Kallikreins; D011205:Povidone
Eksperimental'naia model' istoshcheniia kallikrein-kininovoĭ sistemy krovi.