title: Both neurotoxin II from venom of Naja naja oxiana and its endogenous analogue induce apoptosis in tumor cells.
abstract: Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues significantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apoptosis in L929 and K562 cells.
authors.affiliation: Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
authors.forename: B N
authors.initials: BN
authors.lastname: Strizhkov
authors.lastname: Blishchenko EYu
authors.forename: D K
authors.initials: DK
authors.lastname: Satpaev
authors.forename: A A
authors.initials: AA
authors.lastname: Karelin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003039:Cobra Neurotoxin Proteins / Q000737:chemistry / Q000633:toxicity*; D003553:Cystine / Q000737:chemistry; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D013552:Swine; D014407:Tumor Cells, Cultured
chemical_list: D003039:Cobra Neurotoxin Proteins; D009419:Nerve Tissue Proteins; D003553:Cystine; C076649:neurotoxin II, Naja naja oxiana