title: Intra-articular therapy of experimental arthritis with a derivative of triamcinolone acetonide incorporated in liposomes.
abstract: Triamcinolone acetonide-21-palmitate was synthesized and incorporated into liposomes for intra-articular treatment of an experimentally-induced arthritis in the knee joints of rabbits. The liposomal formulation was more efficient than free triamcinolone acetonide in solution in suppressing the arthritis. Using radioactive tracers, it was found that triamcinolone acetonide-21-palmitate incorporated into liposomes was retained in the articular cavity, together with the liposomal lipids, for a much longer period than free triamcinolone acetonide, and this correlated with its anti-inflammatory effect.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de Murcia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: López-García
authors.forename: J M
authors.initials: JM
authors.lastname: Vázquez-Autón
authors.forename: F
authors.initials: F
authors.lastname: Gil
authors.forename: R
authors.initials: R
authors.lastname: Latoore
authors.forename: F
authors.initials: F
authors.lastname: Moreno
authors.forename: J
authors.initials: J
authors.lastname: Villalaín
authors.forename: J C
authors.initials: JC
authors.lastname: Gómez-Fernández
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002351:Carrageenan; D004337:Drug Carriers; D007270:Injections, Intra-Articular; D007719:Knee Joint; D008081:Liposomes; D011817:Rabbits; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D014316:Tritium
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D014316:Tritium; D002351:Carrageenan; D014222:Triamcinolone Acetonide