[In vitro study of anthelmintic influence on activities of digestive enzymes in extracts from the gut of Ascaris suum and pig's pancreas].
The effect of eight anthelmintics (Rintal, Fenbesan, Telmin, Banminth, Pyrantel, Nilverm, Levamisol and Bioscardina) on the alpha- and gamma-amylases, trypsin, and lipase from pig's pancreas and gut of Ascaris suum was determined. In extracts from A. suum gut also the maltase, trehalase and saccharose activities were examined. All drugs tested did not influence on the host's alpha-amylase. Telmin and Bioscardina were inhibitors of gamma-amylase, Rintal and Telmin--of trypsin, Fenbesan and Bioscardina--of lipase from pig's pancreas. Among the parasite's enzymes the lipase was the most sensitive. Its activity was decreased (35-60%) by Telmin, Nilverm and both pyrantel derivatives. The activity of maltase and trehalase was reduced by Levamisole and Banminth, that of saccharose by Levamisole. It is concluded that the anthelmintics Levamisole and Banminth seemed the most efficient among the tested drugs because they did not alter the activity of host's enzymes and, showed the inhibitory effect on three of parasite's enzymes.
Zółtowska
K
K
Katedra Biologii Ogólnej, Instytut Biologii WSP, Olsztyn.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001200:Ascaris / Q000187:drug effects* / Q000201:enzymology; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects* / Q000201:enzymology; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology; D012680:Sensitivity and Specificity; D013552:Swine
D000871:Anthelmintics
Badania in vitro wpływu leków przeciwrobaczych na aktywność enzymów trawiennych w wyciagach z jelita Ascaris suum i trzustki wieprzowej.