Cancer-associated retinopathy with retinal phlebitis.
A 50-year-old man with cancer-associated retinopathy was investigated using light and electron microscopy, immunofluorescence studies, and western blotting. He had visual disturbance, ring-like scotoma, and night blindness bilaterally. There were narrowed retinal arterioles and dilated retinal venules. Oral corticosteroid therapy had positive effects. Immunostaining using the patient's serum revealed a positive reaction in the ganglion cell layer of normal retina. Western blotting showed that the patient's serum antibody reacted with normal retinal proteins of 24 and 48 kDa. Multiple metastases were evident at autopsy.
Ohnishi
Y
Y
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ohara
S
S
Sakamoto
T
T
Kohno
T
T
Nakao
F
F
D000951:Antigens, Neoplasm / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000150:complications*; D005136:Eye Proteins / Q000276:immunology; D005451:Fluorescein Angiography; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010689:Phlebitis / Q000209:etiology / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000276:immunology; D014794:Visual Fields
D000951:Antigens, Neoplasm; D005136:Eye Proteins