A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area.
The distribution of glutamate receptors in the rat hippocampus was investigated 24 h after the social stress of confrontation with a dominant opponent. AMPA-type glutamate receptors were labeled with the antagonist [3H]CNQX, and NMDA-type receptors were labeled with the competitive antagonist [3H]CGP39653. Increased [3H]CGP39653 labeling was exclusively found in the CA3 stratum radiatum and a decreased [3H]CNQX labeling was found in several hippocampal areas. Consequently, the ratio NMDA/AMPA binding was significantly increased in CA3 stratum oriens and CA3 stratum radiatum. These results suggest that a single unescapable social stress of defeat alters the impact of the excitatory neurotransmitter glutamate, which is restricted to hippocampal CA3 neurons. Possible consequences of the present findings are discussed.
Krugers
H J
HJ
Department of Biological Psychiatry, University of Groningen, The Netherlands.
Koolhaas
J M
JM
Bohus
B
B
Korf
J
J
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives / Q000494:pharmacology; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D018691:Excitatory Amino Acid Antagonists; D006624:Hippocampus / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D018091:Receptors, AMPA; D017470:Receptors, Glutamate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D012919:Social Behavior; D013315:Stress, Psychological / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D011810:Quinoxalines; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C069052:CGP 39653; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D015763:2-Amino-5-phosphonovalerate