[The expression of activation markers on decidual lymphocytes in the first trimester of pregnancy].
To characterize the expression of activation markers CD69, IL-2R alpha, HLA-DR and transferrin receptor on decidual CD3+ and CD56+ lymphocytes, two color flow cytometry were used. Our data suggest the local activation of decidual lymphocytes. CD3+ and CD56+ cells from decidua expressed a high level of CD69 antigens. However, decidua CD3+ and CD56+ cells were different in expression of HLA-DR and IL-2R alpha. Vast majority of decidual CD3+ cells did not express IL-2R alpha and more than 50% of them were HLA-DR positive. Decidual CD56+ lymphocytes were mostly HLA-DR negative and 17% of them bore IL-2R alpha. Distinct patterns of expression of activation markers on decidual lymphocytes may be of immunobiological significance in maintenance of pregnancy.
Slukvin
I I
II
Chernyshov
V P
VP
Merkulova
A V
AV
D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D003656:Decidua / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D037181:Lectins, C-Type; D008213:Lymphocyte Activation / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D015375:Receptors, Interleukin-2 / Q000032:analysis; D011990:Receptors, Transferrin / Q000032:analysis; D012016:Reference Values; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D006684:HLA-DR Antigens; D037181:Lectins, C-Type; D015375:Receptors, Interleukin-2; D011990:Receptors, Transferrin; D000099192:CD69 Antigens
Ekspressiia aktivatsionnykh markerov na detsidual'nykh limfotsitakh v pervom trimestre beremennosti.