An analysis of intravenous hyperalimentation (IVH) catheter-related infection in a university hospital in Japan over a ten year period (1982-1991).
In order to follow changes in clinical characteristics of IVH catheter-related infections, 183 patients were analyzed in whom microorganisms had been isolated from the tips of IVH catheters over a ten year period (1982-1991) in our university hospital. In 183 patients, the male to female ratio was 2.4, the internal medicine departments (Int. Med. Depts.) to surgical departments (Surg. Depts.) ratio was 0.49, 58% of the patients were over 60 years old, 27% had surgical procedures within 30 days before isolation of organisms, and 44% died before discharge. Malignancies were the highest in number for underlying diseases. The same strains of microorganisms as tip cultures were isolated from blood in around 48% of cases in which blood cultures were employed. In the first 5 years (n = 71) and the latter 5 years (n = 112), the proportion of patients form the Int. Med. Depts. increased from 21 to 40% (p < 0.01), and the proportion of Gram positive bacteria from 44 to 64% (p < 0.01). Their antibiotic sensitivity was, as a whole, slightly lower in the latter 5 years. Among Gram-negative bacteria, P. aeruginosa has shown a tendency to increase (11 to 35%). Clinical features were different depending on the kinds of organisms or types of underlying diseases. Measures against IVH catheter-related infections are discussed.
Mizushima
Y
Y
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Daimon
Y
Y
Oota
T
T
Morinaga
S
S
Kashii
T
T
Nakagawa
K
K
Kobayashi
M
M
D000293:Adolescent; D000328:Adult; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D002648:Child; D015897:Comorbidity; D004352:Drug Resistance, Microbial; D004866:Equipment Contamination; D005260:Female; D016469:Fungemia / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D006748:Hospital Departments / Q000706:statistics & numerical data; D006785:Hospitals, University; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D010289:Parenteral Nutrition, Total; D011379:Prognosis; D012189:Retrospective Studies