title: Evaluation of postnatal renal function in fetuses with bilateral obstructive uropathies by proton nuclear magnetic resonance spectroscopy.
abstract: OBJECTIVE
  To precisely evaluate fetal renal function in cases of bilateral fetal urinary tract obstruction, we analyzed fetal urine metabolites by nuclear magnetic resonance spectroscopy.
  
  
  METHODS
  Fifty-six specimens of fetal urine samples in utero were retrospectively analyzed by proton nuclear magnetic resonance. Group 1 (n = 21) consisted of survivors for > or = 1 year with normal serum creatinine (< 50 mumol/L), for group 2 (n = 17) of survivors with abnormal serum creatinine (> 50 mumol/L), and group 3 (n = 18) of those with bilateral histologic dysplasia associated with fetal (termination of pregnancy) or neonatal death.
  
  
  RESULTS
  A specific nuclear magnetic resonance profile was obtained for each of the three groups of renal function. A two-dimensional representation of alanine-valine and valine-threonine concentrations allows clear differentiation between the three degrees of renal function, with a sensitivity and specificity of 88% and 86%, respectively.
  
  
  CONCLUSIONS
  In fetal bilateral urinary tract obstruction a fetal urine nuclear magnetic resonance profile allows an accurate identification of renal function at birth.
authors.affiliation: Laboratoire RMN, Hôpital Saint-Louis, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Eugène
authors.forename: F
authors.initials: F
authors.lastname: Muller
authors.forename: M
authors.initials: M
authors.lastname: Dommergues
authors.forename: L
authors.initials: L
authors.lastname: Le Moyec
authors.forename: Y
authors.initials: Y
authors.lastname: Dumez
mesh_terms: D000596:Amino Acids / Q000652:urine; D002241:Carbohydrates / Q000652:urine; D005315:Fetal Diseases / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D009682:Magnetic Resonance Spectroscopy; D014517:Ureteral Obstruction / Q000378:metabolism*; D014524:Urethral Obstruction / Q000378:metabolism*; D014556:Urine / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D002241:Carbohydrates