title: Intracellular calcium dynamics and cerebral injury: modeling various insults in vitro.
abstract: The magnitude and time course of intracellular [Ca2+]i alterations were studied after excitatory amino acid challenge (EAA) or chemical energy depletion in mature spinal cultures. While either cytotoxic event led to prompt increases in [Ca2+]i, the pattern of these changes before and after exposure to the toxin was different. EAA [Ca2+]i changes seem primarily dependent on surface membrane alterations from which the cells rapidly recover while energy depletion effects release of [Ca2+]i from intracellular stores and produces a lasting compromise in the ability of these neurons in culture to recover from the initial insult.
authors.affiliation: Department of Physiology, Ohio State University, Columbus 43210.
authors.forename: M H
authors.initials: MH
authors.lastname: Kim-Lee
authors.forename: B T
authors.initials: BT
authors.lastname: Stokes
authors.forename: D K
authors.initials: DK
authors.lastname: Anderson
mesh_terms: D001930:Brain Injuries / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004734:Energy Metabolism / Q000502:physiology; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D008959:Models, Neurological; D016202:N-Methylaspartate / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D016202:N-Methylaspartate; D002118:Calcium