Receptor-activated modulation in rat cortical slices as measured with a K-sensitive electrode.
The effects of a variety of presynaptic receptor-activating modulating agents on potassium efflux have been investigated using a potassium (K)-sensitive extracellular electrode in rat brain cortical slices that are electrically stimulated. Purinergic, alpha 2-adrenergic, opioid and muscarinic drugs all increased K outflow. When these agents were used in combination at maximal concentrations, only morphine promoted a further increase in K efflux, suggesting that it utilized a different K channel or acted on cellular elements different from those of the other modulators.
Zoltay
G
G
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Cooper
J R
JR
D015762:2-Chloroadenosine / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D004558:Electric Stimulation / Q000379:methods; D066298:In Vitro Techniques; D008839:Microelectrodes; D009020:Morphine / Q000494:pharmacology; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D018341:Receptors, Adrenergic, alpha-2; D011976:Receptors, Muscarinic; D011957:Receptors, Opioid; D011983:Receptors, Purinergic; D015762:2-Chloroadenosine; D009020:Morphine; D002217:Carbachol; D003000:Clonidine; D011188:Potassium