Oncogene elements within an endogenous retrovirus.
The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.
Whartenby
K A
KA
Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642.
Insel
R A
RA
Freeman
S M
SM
Keng
P
P
Abraham
G N
GN
D001483:Base Sequence; D015139:Blotting, Southern; D002453:Cell Cycle; D002461:Cell Line, Transformed; D005814:Genes, Viral; D011905:Genes, ras; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D012190:Retroviridae / Q000235:genetics*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured