[The comparative characteristics and receptor mechanism of the effect of adenosine-receptor agonists in total cerebral ischemia].
The duration of gasping has no normal distribution, so nonparametric statistic criteria should be used. Three adenosine receptor agonists have a highly cerebro-protective effect which decreases in the order: N-ethylcarboxamide adenosine > > cyclohexyl adenosine > adenosine. Theophylline completely blocks these effects. Thus, they act through adenosine receptors. Adenosine receptor agonist are likely to protect themselves neurons.
Kulinskiĭ
V I
VI
Usov
L A
LA
Sufianova
G Z
GZ
Lidak
M Iu
MIu
Iurkevich
A M
AM
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D001049:Apnea / Q000188:drug therapy / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008297:Male; D051379:Mice; D018047:Receptors, Purinergic P1 / Q000187:drug effects* / Q000502:physiology; D013806:Theophylline / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use
D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D019830:Adenosine-5'-(N-ethylcarboxamide); C027513:N(6)-cyclohexyladenosine; D013806:Theophylline; D000241:Adenosine
Sravnitel'naia kharakteristika i retseptornyĭ mekhanizm éffekta agonistov adenozinovykh retseptorov pri polnoĭ ishemii golovnogo mozga.