title: Effect of ceruletide on epileptogenesis in amygdaloid kindled rats.
abstract: The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 micrograms/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 micrograms/kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.
authors.affiliation: Department of Physiology, Kagawa Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Itano
authors.forename: O
authors.initials: O
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: N A
authors.initials: NA
authors.lastname: Janjua
authors.forename: H
authors.initials: H
authors.lastname: Suwaki
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Negi
authors.forename: T H
authors.initials: TH
authors.lastname: Murakami
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D004558:Electric Stimulation; D004827:Epilepsy / Q000517:prevention & control*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002108:Ceruletide