Heparin surface treatment of poly(methylmethacrylate) alters adhesion of a Staphylococcus aureus strain: utility of bacterial fatty acid analysis.
Bacterial adhesion on biomaterials is an important cause of associated infection. Many authors have studied the adhesion mechanisms of bacteria on biomaterials. These studies were useful in making materials more and more refractory to bacterial adhesion. We analysed the gas chromatographic modifications of structural fatty acids of a Staphylococcus aureus strain after adhesion on two polymers, poly(methylmethacrylate) (PMMA), whose biological compatibility is known, and heparin-surface-modified PMMA (HSM-PMMA). We noted changes to the chromatographic peaks peculiar to the fatty acids of S. aureus for each tested material and particularly for HSM-PMMA.
Arciola
C R
CR
Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy.
Radin
L
L
Alvergna
P
P
Cenni
E
E
Pizzoferrato
A
A
D001422:Bacterial Adhesion / Q000187:drug effects* / Q000502:physiology; D001424:Bacterial Infections / Q000517:prevention & control; D001672:Biocompatible Materials / Q000009:adverse effects / Q000494:pharmacology*; D002473:Cell Wall / Q000737:chemistry; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D008768:Methylmethacrylates / Q000009:adverse effects / Q000494:pharmacology*; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000737:chemistry / Q000187:drug effects; D013499:Surface Properties
D001672:Biocompatible Materials; D005227:Fatty Acids; D008768:Methylmethacrylates; D006493:Heparin