title: Respiratory syncytial virus subgroup B dominance during one winter season between 1987 and 1992 in Vancouver, Canada.
abstract: A subgroup analysis of 613 specimens submitted to the British Columbia's Children's Hospital from 1987 to 1992 revealed that subgroups A and B of respiratory syncytial virus (RSV) were both circulating in our community, with some predominance for subgroup A during the period from October 1987 to September 1988 (the 1987-88 season) (64%), 1990-91 (60%), and 1991-92 (62%). During 1989-90 subgroup A represented the majority of isolates (80%). Subgroup B predominated during only one season, 1988-89 (94%). No microheterogeneity within subgroups was apparent as judged by the monoclonal antibody reactivity pattern. More male than female children were affected overall, but no sex-related difference between subgroup infections could be detected (P = 0.28). The majority of patients were less than 1 year of age, and no significant association between age and subgroup was detected after stratifying for year (P = 0.64). This is, to our knowledge, the first comprehensive longitudinal RSV subgroup prevalence study from the Pacific Northwest and from Canada.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of British Columbia.
authors.forename: E
authors.initials: E
authors.lastname: Thomas
authors.forename: M J
authors.initials: MJ
authors.lastname: Margach
authors.forename: C
authors.initials: C
authors.lastname: Orvell
authors.forename: B
authors.initials: B
authors.lastname: Morrison
authors.forename: E
authors.initials: E
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral / Q000032:analysis; D001955:British Columbia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D018357:Respiratory Syncytial Virus Infections / Q000145:classification / Q000453:epidemiology*
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral