Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity.
Streptomyces filipinensis NR 0484 produced a new DNA gyrase inhibitor, cyclothialidine. It showed potent activity against DNA gyrases from Escherichia coli and Micrococcus luteus.
Watanabe
J
J
Nippon Roche Research Center, Kanagawa, Japan.
Nakada
N
N
Sawairi
S
S
Shimada
H
H
Ohshima
S
S
Kamiyama
T
T
Arisawa
M
M
D000818:Animals; D002417:Cattle; D004926:Escherichia coli / Q000201:enzymology; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000201:enzymology; D010456:Peptides, Cyclic; D011758:Pyrroles / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D059005:Topoisomerase II Inhibitors
D006571:Heterocyclic Compounds; D010456:Peptides, Cyclic; D011758:Pyrroles; D059005:Topoisomerase II Inhibitors; C085889:cyclothialidine