The role of fast neutron therapy in unresectable pelvic osteosarcoma: preliminary report.
Primary osteosarcoma of the pelvic bones represents less than 10% of all osteosarcoma. Despite mutilating surgical procedures or high-dose radiotherapy and neoadjuvant chemotherapy, local failures and distant metastases remain common. The 2-year actuarial survival rate is less than 50% and the disease-free survival is under 20% at 2 years. We report 4 cases of pelvic osteosarcoma treated by a combination of chemotherapy, photon beam and neutron beam radiotherapy. After a median follow-up of 24 months, all 4 patients are alive and disease free.
Carrie
C
C
Radiotherapy Department, Centre Léon Bérard, Lyon, France.
Breteau
N
N
Negrier
S
S
Frappaz
D
D
Bouffet
E
E
Thiesse
P
P
Blay
J Y
JY
Clavel
M
M
Philip
T
T
Biron
P
P
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005214:Fast Neutrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000532:radiotherapy*; D010384:Pelvic Bones; D017785:Photons / Q000627:therapeutic use