Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.
The specification of the R7 photoreceptor cell fate in the developing eye of Drosophila depends on the local activation of the sevenless (Sev) receptor tyrosine kinase by Boss, a protein expressed on the membrane of the neighbouring R8 cell. Constitutive activation of the Sev receptor results in a dosage-dependent increase in the number of R7 cells per ommatidium. Genetic screens have been used to identify mutations that alter the efficiency of signal transduction. Subsequent molecular characterization of the corresponding genes has led to the identification of a number of proteins involved in transducing the signal from the receptor to the nucleus. In contrast to the receptor and its ligand, these components are shared between different signal transduction pathways not only in Drosophila but are also homologous to components involved in signal transduction in other organisms.
Hafen
E
E
Zoologisches Institut, Universität Zürich, Switzerland.
Dickson
B
B
Brunner
T
T
Raabe
T
T
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D004330:Drosophila / Q000201:enzymology / Q000502:physiology*; D029721:Drosophila Proteins; D005136:Eye Proteins / Q000378:metabolism*; D005808:Genes, Recessive; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009154:Mutation; D010786:Photoreceptor Cells / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf; D020794:Receptor Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D013045:Species Specificity; D014714:Vertebrates / Q000502:physiology
D029721:Drosophila Proteins; D005136:Eye Proteins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C056737:sev protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf