Influence of 1,3-di-o-tolylguanidine and rimcazole, selective sigma ligands, on apomorphine and neuroleptic effects.
1,3-di-o-tolylguanidine and rimcazole act as typical neuroleptics (antagonize the apomorphine-induced aggression and climbing) and at the same time, as dopamine stimulants (antagonize neuroleptic-induced catalepsy). When given alone, they exhibit no visible behavioral effects.
Maj
J
J
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Rogóz
Z
Z
Skuza
G
G
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced* / Q000188:drug therapy; D004298:Dopamine / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D008024:Ligands; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002227:Carbazoles; D006146:Guanidines; D008024:Ligands; C034931:rimcazole; C050232:1,3-ditolylguanidine; D001058:Apomorphine; D004298:Dopamine