[Assay of plasma amino acid concentration in maternal and growth-retarded fetuses caused by passive smoking in rabbits].
Rabbits were exposed to cigarette smoking in: (1) Group A: everyday exposure in the whole period of pregnancy (n = 9); (2) Group B: everyday exposure in the late half period of pregnancy (n = 7); (3) Group C: non-smoking (n = 7). The results showed that the fetal rabbits in group A had combined symmetric and asymmetric IUGR, Group B asymmetric IUGR. The maternal plasma total amino acid concentration in both experimental groups is not different significantly to that of the control group. All the essential amino acid concentrations were lower, some of the nonessential amino acid were lower and some were higher than that of the control group. The fetus in both experimental groups had significantly lower plasma concentrations of total amino acid and most of the essential and nonessential amino acids when compared with that of the control group. This was mainly because of a reduction of the branched chain amino acids lysine, phenylalanine, methionine, isoleucine, leucine, valine, serine, glutamine, alanine, tyrosine and histidine. Fetal plasma amino acid concentrations decreased more significantly than that of the maternal's and most of fetal/maternal amino acid concentration ratios in both experimental group were lower than that of the control group.
Zhang
X Q
XQ
Ren Ji Hospital Shanghai, Second Medical University.
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011817:Rabbits; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D000596:Amino Acids; D014028:Tobacco Smoke Pollution