[Detection of risk factors for hemodynamic dysadaptation under physical loading based on data from genetic studies (Part 1)].
Twenty-eight pairs of unisexual healthy twins were examined during exercise, on anapriline or their combination. The twin technique of calculating the additive component of blood pressure and catecholamine levels was used in each of the terms of the examination. beta-adrenoceptor blockade was found to be a highly potent environmental factor under whose influence both resting and exercise blood pressures were not provided by inheritable regulatory mechanisms. The latter resulted in tense synthetic function of the sympathoadrenal system and in disadaptation of the cardiovascular system when anapriline and exercise were used, which might serve an individual prognostic criterion of exercise tolerance.
Pereponov
Iu P
IuP
Belova
E V
EV
Lil'in
E T
ET
D000222:Adaptation, Physiological / Q000187:drug effects / Q000235:genetics; D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology; D000328:Adult; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D002395:Catecholamines / Q000652:urine; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects / Q000235:genetics; D006439:Hemodynamics / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D011433:Propranolol; D012016:Reference Values; D012307:Risk Factors; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology / Q000652:urine; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D002395:Catecholamines; D011433:Propranolol
Vyiavleniie faktorov riska gemodinamicheskoĭ dezadaptatsii pri fizicheskoĭ nagruzke po dannym geneticheskikh issledovaniĭ (soobshchenie 1).