Erythrocyte membrane structure in bipolar affective disorder: a non-replication.
Fifteen bipolar patients were compared with sixteen controls in an attempt to replicate the findings of Pettegrew et al. in 1982 of decreased fluidity in the hydrocarbon core of the erythrocyte membrane. No significant differences were seen between groups. The present control group shows very similar membrane characteristics to the original control series; however, the bipolar patient group is not similar. Possible explanations are discussed.
Nurnberger
J
J
Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis 46202-4887.
Miller
M
M
Bowman
E
E
Sullivan
J
J
Brittain
H
H
Lawrence
D
D
York
C
C
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D004359:Drug Therapy, Combination; D004907:Erythrocyte Deformability / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005454:Fluorescence Polarization; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D016651:Lithium Carbonate