Evaluation of cellular proliferation in human biopsy samples of lymphoid tissue according to the expression of AgNORs.
The proportions of cells with a high expression of AgNORs, as directly assessed under the light microscope, and those of Ki-67-immunoreactive cells were divided into three categories (low, < 25%; intermediate, 25-50%; high, > 50%) and compared to a series of 41 human biopsy samples of lymphoid tissue. Irrespective of histological features a strong correlation was found between both variables (contingency coefficient = 0.8; P < 0.001). It is concluded that direct evaluation of cells with a high expression of AgNORs may serve as an index of proliferative activity in biopsy samples of lymphoid tissue.
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Department of Pathology, Hospital Clinico of Salamanca, Spain.
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Carbajo-Pérez
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D001706:Biopsy; D002455:Cell Division; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology* / Q000601:surgery; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D009697:Nucleolus Organizer Region / Q000473:pathology*; D016622:Silver Staining