title: The phase of the menstrual cycle has no influence on the disease-free survival of patients with mammary carcinoma.
abstract: We evaluated the outcome of treatment for mammary carcinoma in 89 premenopausal women in relation to the phase of the menstrual cycle. The phase of the cycle was determined on the basis of serum concentrations of 17 beta-oestradiol and progesterone. The serum samples were collected 1 day prior to or on the day of operation. After a median follow-up of 4.1 years no significant differences in disease-free survival were found between the preovulatory (proliferative), periovulatory and post-ovulatory (luteal) groups. No differences in survival were found in these subgroups between the N0 and N1 subgroup. On the basis of this study we cannot confirm that the phase of the menstrual cycle during surgery has any effect on the eventual outcome in mammary carcinoma patients. However larger studies of this type are required before definitive conclusions can be reached.
authors.affiliation: Department of Surgery, University Hospital Nijmegen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Wobbes
authors.forename: C M
authors.initials: CM
authors.lastname: Thomas
authors.forename: M F
authors.initials: MF
authors.lastname: Segers
authors.forename: P G
authors.initials: PG
authors.lastname: Peer
authors.forename: E D
authors.initials: ED
authors.lastname: Bruggink
authors.forename: L V
authors.initials: LV
authors.lastname: Beex
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D004958:Estradiol / Q000097:blood; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D008597:Menstrual Cycle / Q000097:blood / Q000502:physiology*; D008727:Methotrexate / Q000008:administration & dosage; D009367:Neoplasm Staging; D011374:Progesterone / Q000097:blood; D011987:Receptors, Steroid / Q000032:analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D011987:Receptors, Steroid; D011374:Progesterone; D004958:Estradiol; D003520:Cyclophosphamide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005472:Fluorouracil; D008727:Methotrexate