title: [Atypical tricyclic neuroleptics for treatment of schizophrenia. Clothiapine and clozapine].
abstract: The main objective of the pharmacotherapy of schizophrenia has been, and still is, to obtain optimal therapeutic efficacy, which is seconded by the aim to restrict as far as possible the sometimes severe collateral effects which are acknowledged as being the major drawback to the regular use of neuroleptic agents. Tight from the start, some "atypical neuroleptics" were identified as being of interest for this reason; these included Clothiapine and Clozapine, a more recently discovered drug which is not yet commercially available in Italy. Both of these neuroleptics have been found to offer extremely interesting advantages. The authors now report data referring to the clinical use of these drugs during 1989-1990 in addition to those published in the literature on this subject.
authors.affiliation: Istituto di Clinica Psichiatrica, Università degli Studi di Catania.
authors.forename: G
authors.initials: G
authors.lastname: Seminara
authors.forename: V
authors.initials: V
authors.lastname: Trassari
authors.forename: N
authors.initials: N
authors.lastname: Prestifilippo
authors.forename: R
authors.initials: R
authors.lastname: Chiavetta
authors.forename: C
authors.initials: C
authors.lastname: Calandra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004361:Drug Tolerance; D005116:Extrapyramidal Tracts / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000145:classification / Q000188:drug therapy / Q000523:psychology; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000378:metabolism
chemical_list: D000929:Antidepressive Agents, Tricyclic; D003987:Dibenzothiazepines; D011985:Receptors, Serotonin; D012701:Serotonin; D003024:Clozapine
vernacular_title: Neurolettici triciclici atipici nella schizofrenia. Clotiapina e clozapina.