title: [Morpho- and pathogenesis of lesions in malignant tumors undergoing photodynamic therapy].
abstract: Morphogenesis of tumour lesions produced by photodynamic therapy (PDT) includes a direct cytotoxic effect, lesions due to the disturbance of microcirculation, lesions by the activated inflammatory cells and cytokines released by these cells (tumour necrosis factor, histamine, prostaglandins). Ultrastructurally, the cell death is due to the cell membrane and nucleus apparatus damage by active oxygen forms and biomolecular radicals.
authors.forename: E A
authors.initials: EA
authors.lastname: Kogan
authors.forename: A A
authors.initials: AA
authors.lastname: Nevol'skikh
authors.forename: N N
authors.initials: NN
authors.lastname: Zharkova
authors.forename: V B
authors.initials: VB
authors.lastname: Loshchenov
mesh_terms: D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D002462:Cell Membrane / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects; D009024:Morphogenesis; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D010778:Photochemotherapy / Q000009:adverse effects*
chemical_list: D016207:Cytokines
vernacular_title: Morfo- i patogenez povrezhdenniĭ zlokachestvennykh opukholeĭ pri fotodinamicheskoĭ terapii.