[The production by bone marrow cells of humoral factors in extreme exposures of different origins].
The intensification of cytokine-producing activity by mouse bone marrow cells forming the hemopoiesis-inducing microenvironment (HIM) was demonstrated to be an obligatory component of adaptation processes developing in the body under the influence of different extreme factors (immobilization, inflammation, cytostatics, irradiation). As a rule, the first stress reaction of adhesive and nonadhesive cells consists in interleukin-1 and interleukin-3 secretion with following erythropoietic and colony-stimulating activity induction. For all this, the levels and periods of production of hemopoiesis humoral regulators are comparable under hemopoiesis-stimulating or -suppressing influences. Finally Activation of HIM functional properties expresses the interaction of central and local regulating systems, which favours the formation of an optimal response of the blood system to stress.
Gol'dberg
E D
ED
Dygaĭ
A M
AM
Khlusov
I A
IA
Bogdashin
I V
IV
Shakhov
V P
VP
Agafonov
V I
VI
Zhdanov
V V
VV
Gumilevskiĭ
B Iu
BIu
Sherstoboev
E Iu
EIu
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D016207:Cytokines / Q000096:biosynthesis* / Q000187:drug effects / Q000528:radiation effects; D004927:Escherichia coli Infections / Q000276:immunology; D006410:Hematopoiesis / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010538:Peritonitis / Q000276:immunology; D012149:Restraint, Physical
D016207:Cytokines
Produktsiia kostnomozhgovymi kletkami gumoral'nykh faktorov pri ékstremal'nykh vozdeĭstviiakh razlichnogo geneza.