title: Metabolic consequences of increasing energy intake by adding lipid to parenteral nutrition in full-term infants.
abstract: The effect on energy metabolism and fuel utilization of increasing energy intake by adding intravenous lipid to a glucose and amino acid regimen was examined. Twenty fullterm, appropriate-for-gestational-age, intravenously fed neonates were entered into one of two groups: total energy intake was 261 kJ.kg-1 x d-1 (62 kcal.kg-1 x d-1) in group 1 and 355 kJ.kg-1 x d-1 (85 kcal.kg-1 x d-1) in group 2. Both groups received 2.8 g protein.kg-1 x d-1 and 14 g glucose.kg-1 x d-1. Group 2 received an additional 2 g lipid.kg-1 x d-1. Metabolic rate, respiratory gas exchange, and nonprotein substrate oxidation were similar in both groups. The addition of energy as lipid enhanced nitrogen retention (230 vs 306 mg.kg-1 x d-1; P < 0.02) and utilization (52.8% vs 66.5%; P < 0.03). Our data suggest that nitrogen utilization is improved in parenterally fed neonates by adding fat and increasing energy intake without change in metabolic rate, carbon dioxide production, oxygen consumption, and nonprotein substrate utilization. Energy expenditure does not necessarily increase with increasing energy intake independently of diet composition.
authors.affiliation: Department of Pediatrics, University of Toronto, Canada.
authors.forename: J E
authors.initials: JE
authors.lastname: Van Aerde
authors.forename: P J
authors.initials: PJ
authors.lastname: Sauer
authors.forename: P B
authors.initials: PB
authors.lastname: Pencharz
authors.forename: J M
authors.initials: JM
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Heim
authors.forename: P R
authors.initials: PR
authors.lastname: Swyer
mesh_terms: D002151:Calorimetry; D002149:Energy Intake; D004734:Energy Metabolism; D005865:Gestational Age; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000008:administration & dosage*; D010101:Oxygen Consumption; D010288:Parenteral Nutrition
chemical_list: D008055:Lipids