Myelodysplastic syndrome with prolonged reticulocyte survival mimicking hemolytic disease.
A patient with myelodysplastic syndrome (refractory anemia) with marked and persistent reticulocytosis is presented. A referring diagnosis of hemolytic disease had been made. However, the 51Cr red cell survival was normal (T1/2 24 days). Reticulocyte morphology, red cell creatine content, and in vitro reticulocyte survival studies have suggested that the reticulocytosis arose as a consequence of delayed maturation of the reticulocytes. Two patients with myelodysplastic syndrome and delayed reticulocyte maturation have previously been described; in both patients, however, red cell survival was also shortened. Anemia with reticulocytosis, mimicking hemolytic disease, may be an unusual presentation of myelodysplastic syndrome.
Sher
G D
GD
Department of Laboratory Hematology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Pinkerton
P H
PH
Ali
M A
MA
Senn
J S
JS
D000368:Aged; D000743:Anemia, Hemolytic / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D012156:Reticulocytes / Q000737:chemistry / Q000473:pathology*
D002860:Chromium Radioisotopes; D003404:Creatinine