The effects of antibiotics and steroids on the carriage of vaginal bacteria into the uterus during insertion of intra-uterine monofilaments in the guinea-pig.
The effects of systemic norethisterone acetate and oxytetracycline hydrochloride on the levels of vaginal microorganisms found in the uterus after the insertion of transcervical, intra-uterine monofilaments in the guinea-pig were determined. The results indicated that bacteria were transferred to the uterus from the vagina during the insertion process and, in the presence of an intra-uterine substrate, persisted for up to 6 months. Daily treatment with norethisterone acetate or oxytetracycline hydrochloride whilst the monofilament was in-situ failed to reduce the bacterial numbers in the uterus. Similarly, daily treatment with oxytetracycline hydrochloride for the 5 days before monofilament insertion had no effect on these bacteria.
Malhi
J S
JS
Department of Pharmacy, University of Brighton, UK.
Gard
P R
PR
Hanlon
G W
GW
D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D015169:Colony Count, Microbial; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007434:Intrauterine Devices / Q000009:adverse effects*; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D010118:Oxytetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology*
D045167:Progesterone Congeners; D000077563:Norethindrone Acetate; D009640:Norethindrone; D010118:Oxytetracycline