title: Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
authors.affiliation: Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105.
authors.forename: D R
authors.initials: DR
authors.lastname: Sliskovic
authors.forename: B R
authors.initials: BR
authors.lastname: Krause
authors.forename: J A
authors.initials: JA
authors.lastname: Picard
authors.forename: M
authors.initials: M
authors.lastname: Anderson
authors.forename: R F
authors.initials: RF
authors.lastname: Bousley
authors.forename: K L
authors.initials: KL
authors.lastname: Hamelehle
authors.forename: R
authors.initials: R
authors.lastname: Homan
authors.forename: T N
authors.initials: TN
authors.lastname: Julian
authors.forename: Z A
authors.initials: ZA
authors.lastname: Rashidbaigi
authors.forename: R L
authors.initials: RL
authors.lastname: Stanfield
mesh_terms: D000042:Absorption; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001682:Biological Availability; D002219:Carbamates / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006937:Hypercholesterolemia / Q000517:prevention & control; D007093:Imidazoles / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D010671:Phenylurea Compounds / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology; D014867:Water
chemical_list: D000924:Anticholesteremic Agents; D002219:Carbamates; D002788:Cholesterol Esters; D007093:Imidazoles; D008055:Lipids; D010671:Phenylurea Compounds; D014867:Water; C086204:((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester; D014508:Urea; C050492:CL 277082; D002784:Cholesterol; C084073:lecimibide; D002785:Sterol O-Acyltransferase