[Comparative analysis of several treatment methods for severe congestive heart failure].
Western medicines (WM) and the combining WM-TCM were used to treat congestive heart failure (CHF). The three groups of WM were: Digoxin with dihydro-chlorothiazide, captopril with nifedipium, and dobutamine. The three groups of combining WM-TCM were: the above-mentioned three groups of WM with Jisen Shenqi Pill (JSSQ) respectively. The result observed: Total effective rate was 82%, marked effective rate was 43%, the rates of the WM groups were 77% and 36% respectively, and the groups of combining WM-TCM were 88% and 53%. Total mortality was 8.66% (the WM groups was 11.76%, the groups of combining WM-TCM 5%). Cardio-function indexes observed in the groups of combining WM-TCM were obviously improved, including HR, SV, CI, EF, FS and A/E (P < 0.01). HR, CI and SV in the groups of WM were also significantly improved (P < 0.05) except for EF, FS and A/E (P > 0.05).


CONCLUSIONS
(1) The treatment of CHF should depend on various conditions and different symptoms in selecting medicines, so that individual treatment could reach the optimal effects. (2) The treatment method of combining WM-TCM could significantly promote effective rate, reduce toxic and side-effects and lower the rate of mortality. (3) JSSQ could obviously improve the function of ventricular diastole and its mechanism might be that the reduced density of beta-receptor was increased.
Lou
Z J
ZJ
Hangzhou TCM Hospital.
Zhu
G L
GL
Sun
X L
XL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002216:Captopril / Q000627:therapeutic use*; D004077:Digoxin / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; D006852:Hydrochlorothiazide; D004077:Digoxin; D002216:Captopril; D009543:Nifedipine