[The functional role of monoaminergic and amino acid-ergic mechanisms of the locus coeruleus in anxiety from different aversive origins].
Dopamine and glutamine acid microinjection in the locus coeruleus of rats does not influence the alarm state in the test of "Threatening situation" avoidance, but weakens the state of alarm in the test of "illuminated site" avoidance. The local injection of GABA and noradrenaline mesatone effect imitators in this brain formation weakens the alarm state in the test of "threatening situation" avoidance but is not effective in the test of "illuminated site" avoidance. On the contrary, the chemical stimulation of locus coeruleus by serotonin influences the anxiolytic effect in two different experimentally modelled states of alarm. The participation of locus coeruleus and acidergic mechanisms in anxiety of diverse aversive genesis is discussed.
Talalaenko
A N
AN
Stakhovskiĭ
Iu V
IuV
Bogdanov
B A
BA
Babiĭ
Iu V
IuV
Perch
N N
NN
D000818:Animals; D001007:Anxiety / Q000209:etiology* / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D015306:Biogenic Monoamines / Q000502:physiology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008845:Microinjections; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017459:Receptors, Amino Acid / Q000187:drug effects / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*
D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D010656:Phenylephrine
Funktsional'naia rol' monoamin- i aminokislotergicheskikh mekhanizmov locus coeruleus v trevoge razlichnogo aversivnogo geneza.