Sulphatide and sulphatide antibodies in insulin-dependent diabetes mellitus.
Insulin-dependent diabetes mellitus (IDDM) is associated with neurological disorders. Sulph I, a monoclonal antibody to sulphatide (a neural epitope), stained secretory granules in alpha and beta cells of rat islets of Langerhans, but not exocrine tissue. Sera from 88% of 57 newly diagnosed IDDM patients was anti-sulphatide positive, and 76% were positive 6 months later. All 135 healthy controls were negative. Sulphatide antibody may be an IDDM marker.
Buschard
K
K
Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark.
Josefsen
K
K
Horn
T
T
Fredman
P
P
D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013433:Sulfoglycosphingolipids / Q000276:immunology*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D013433:Sulfoglycosphingolipids