title: Partial deficiency of thyroxine-binding globulin: an HLA study.
abstract: Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothyroidism during 1988-1990. Analysis of the HLA system revealed the possibility that antigen DR6 may be considered as a risk factor for TBG deficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37.5%). Similar laboratory findings were also present in 16 mothers and 1 father.
authors.affiliation: Clinic of Children and Adolescents, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Hníková
authors.forename: E
authors.initials: E
authors.lastname: Ivasková
authors.forename: P
authors.initials: P
authors.lastname: Kracmar
authors.forename: L
authors.initials: L
authors.lastname: Kupková
authors.forename: H
authors.initials: H
authors.lastname: Sajdlová
authors.forename: J
authors.initials: J
authors.lastname: Zikmund
mesh_terms: D003409:Congenital Hypothyroidism; D005260:Female; D015802:HLA-DR2 Antigen / Q000097:blood*; D015808:HLA-DR6 Antigen / Q000097:blood*; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D013975:Thyroxine-Binding Proteins / Q000032:analysis / Q000172:deficiency*
chemical_list: D015802:HLA-DR2 Antigen; D015808:HLA-DR6 Antigen; D013975:Thyroxine-Binding Proteins