Striatal [11C]-N-methyl-spiperone binding in patients with focal dystonia (torticollis) using positron emission tomography.
Specific binding of [11C]-N-methyl-spiperone to striatal dopamine D2 receptors was assessed using positron emission tomography (PET) in 6 patients with adult-onset focal dystonia (predominantly spasmodic torticollis) and in 5 healthy subjects. No significant difference in average specific striatal tracer uptake between patients and healthy subjects was found. However, in the 5 patients showing lateralisation of clinical signs a trend to higher striatal tracer uptake in the contralateral hemisphere was observed.
Leenders
K
K
Paul Scherrer Institute, Villigen, Switzerland.
Hartvig
P
P
Forsgren
L
L
Holmgren
G
G
Almay
B
B
Eckernäs
S A
SA
Lundqvist
H
H
Långström
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D015259:Dopamine Agents / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013134:Spiperone / Q000031:analogs & derivatives* / Q000378:metabolism; D014055:Tomography, Emission-Computed; D014103:Torticollis / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology
D015259:Dopamine Agents; D017448:Receptors, Dopamine D2; D013134:Spiperone; C039167:3-N-methylspiperone