Functional activity in host and graft lymphoid tissue of rats receiving syngeneic heterotopic small bowel transplants with portal or systemic drainage.
Adult Lewis rats received syngeneic accessory small bowel transplants (SBT) with venous drainage to the portal vein (PV) or the inferior vena cava (IVC)/hetero-portal (HP) or hetero-systemic (HS) grafts, respectively. At varying times thereafter (5-300 days post-transplantation) animals were killed and cells from different lymphoid organs were tested in vitro for their generation of lymphoproliferative and cytotoxic T-cell responses, as well as their ability to produce a variety of lymphokines after alloantigen or mitogen stimulation. Despite marked decreases in cell recovery in Peyer's Patches of HS rats, no significant loss of cell function (on a per cell basis) was noted in any animal group. Total recovered activity per organ was decreased in small intestinal tissue (host and graft) of HS recipients regardless of the assay under study.
Gorczynski
R M
RM
Department of Surgery, University of Toronto, Ontario, Canada.
Cohen
Z
Z
Plapler
H
H
Levy
G
G
Wojcik
D
D
Koh
I
I
D000818:Animals; D003602:Cytotoxicity, Immunologic; D007421:Intestine, Small / Q000098:blood supply / Q000276:immunology* / Q000637:transplantation*; D007959:Lymphocyte Culture Test, Mixed; D008221:Lymphoid Tissue / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis; D010581:Peyer's Patches / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D016042:Transplantation, Heterotopic
D008222:Lymphokines