title: Tamoxifen failure in medullary thyroid carcinoma.
abstract: We report the results of short-term tamoxifen treatment (20 mg two times a day orally) in 2 patients with metastatic medullary thyroid carcinoma. Patient A had a rapid tumor progression with development of Cushing's syndrome before initiation of tamoxifen treatment. Patient B had a slowly progressive course. In both cases, neither clinical nor biochemical improvement were observed, after 1 and 3 months of tamoxifen therapy, respectively.
authors.affiliation: Division of Endocrinology, Hospital Mutua de Terrassa, University of Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: García-Pascual
authors.forename: M
authors.initials: M
authors.lastname: Millán
authors.forename: J
authors.initials: J
authors.lastname: Anglada
authors.forename: J
authors.initials: J
authors.lastname: Garau
mesh_terms: D000328:Adult; D018276:Carcinoma, Medullary / Q000188:drug therapy*; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000627:therapeutic use*; D013964:Thyroid Neoplasms / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D013629:Tamoxifen