title: [Prophylactic effect of oral terbinafine on the development of infection in guinea pigs inoculated with Trichophyton mentagrophytes].
abstract: Prophylactic effect was studies of a novel oral antifungal agent terbinafine (TBF) on the development of local infection in guinea pigs after inoculation of Trichophyton mentagrophytes. TBF was administered orally in a single dose of 6.25 or 12.5 mg/kg, 8, 24, 48 or 72 hrs before the inoculation, and the drug effect was assessed on the basis of local symptoms and culture study. The result of experiments demonstrated that oral TBF more or less prevented the development of the dermatophytic infection, depending on the dosage and the timing of administration, the complete prevention was achieved in the animals that were administered with 12.5 mg/kg of TBF 24 hrs prior to the inoculation of T. mentagrophytes. This suggests a good transferability and intracutaneous retaining of orally administered TBF.
authors.affiliation: Research Center for Medical Mycology, Teikyo University.
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000077291:Terbinafine; D014005:Tinea / Q000517:prevention & control*
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine