Disturbed release of growth hormone in mature dogs: a comparison with congenital growth hormone deficiency.
An acquired defect in growth hormone secretion in mature dogs has been associated with some forms of generalised alopecia. In an attempt to elucidate the pathogenesis of the disturbance in growth hormone release, the plasma concentrations of growth hormone and insulin-like growth factor I (IGF-I) were measured in two seven-year-old poodles with alopecia and, for comparison, in two young German sheperd dogs with congenital hyposomatotropism (pituitary dwarfism). In the poodles the basal concentrations of growth hormone were low, although often above the detection limit of the assay. The concentrations of IGF-I were in the reference range for healthy poodles. No growth hormone could be detected in the plasma of the German sheperd dogs and the concentrations of IGF-I were very low. Stimulation with clonidine and growth hormone releasing hormone (GHRH) before and after repeated injections of GHRH did not result in significant increases in growth hormone concentrations in plasma. The concentrations of growth hormone in the poodles fluctuated at low levels during the test period. In the German sheperd dogs the levels of growth hormone remained unmeasurable during the stimulation tests. It was concluded that in the two poodles the basal concentrations of growth hormone were sufficient to maintain normal IGF-I concentrations, and thus the release of growth hormone was considered appropriate. Based upon measurements of urinary corticoids and a review of the literature it is suggested that the lack of a growth hormone response to stimulation was due to the enhanced release of somatostatin as a result of mild and fluctuating hyperadrenocorticism.(ABSTRACT TRUNCATED AT 250 WORDS)
Rijnberk
A
A
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
van Herpen
H
H
Mol
J A
JA
Rutteman
G R
GR
D000305:Adrenal Cortex Hormones / Q000652:urine; D000367:Age Factors; D000505:Alopecia / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D003404:Creatinine / Q000652:urine; D003907:Dexamethasone / Q000494:pharmacology; D004283:Dog Diseases / Q000209:etiology* / Q000378:metabolism; D004285:Dogs; D004393:Dwarfism, Pituitary / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000172:deficiency* / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay
D000305:Adrenal Cortex Hormones; D007334:Insulin-Like Growth Factor I; D003907:Dexamethasone; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D003404:Creatinine; D003000:Clonidine