title: Serotonin (5-HT) fibers of the rat dura mater: 5-HT-positive, but not authentic serotoninergic, tryptophan hydroxylase-like fibers.
abstract: Serotonin (5-HT)-positive, but not tryptophan-5-hydroxylase (TPOH)-positive, authentic serotoninergic fibers were shown in the rat dura mater. 5-HT immunoreactive fibers in the dura are postulated to result from 5-HT uptake from circulating blood elements (e.g. platelets, mast cells) by perivascular sympathetic nerve fibers. A robust TPOH-immunoreactive mast cell population was identified in the dura; this result confirms the TPOH antibody specificity to cells known to synthesize 5-HT. While these results indicate that there are no authentic serotoninergic fibers in the dura mater, the mast cells, platelets and cerebrospinal fluid can serve as a source of 5-HT activating 5-HT receptors known to be present in this tissue.
authors.affiliation: Department of Neurosurgery, College of Medicine, University of Cincinnati, OH 45267-0515.
authors.forename: M I
authors.initials: MI
authors.lastname: Stanley
authors.forename: R J
authors.initials: RJ
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Zuccarello
authors.forename: J T
authors.initials: JT
authors.lastname: Keller
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D004299:Dopamine beta-Hydroxylase / Q000276:immunology / Q000378:metabolism; D004388:Dura Mater / Q000166:cytology* / Q000201:enzymology; D007150:Immunohistochemistry; D008297:Male; D008407:Mast Cells / Q000201:enzymology; D009412:Nerve Fibers / Q000201:enzymology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000502:physiology*; D014365:Tryptophan Hydroxylase / Q000502:physiology*
chemical_list: D012701:Serotonin; D014365:Tryptophan Hydroxylase; D004299:Dopamine beta-Hydroxylase