A developmentally regulated basic-leucine zipper-like gene and its expression in embryonic retina and lens.
Transcriptional regulators play important roles in the control of key developmental events. We have identified sw3-3, a likely candidate for such a function, in tissues of the eye and other neural organs. It encodes a basic-leucine zipper-like protein, in which two leucine zipper motifs flank a basic domain. The latter contains helix-disturbing amino acids such as glycine and proline, at positions occupied by conserved asparagine and alanine residues (respectively) in "conventional" basic-leucine zipper proteins. sw3-3 is widely expressed at early embryonic stages in the lens, retina, and other neural tissues and is down-regulated thereafter with a spatial and temporal pattern that correlates with the cessation of mitotic activity and the onset of cell migration and differentiation.
Wang
S Z
SZ
Retinal Degenerations Research Center, Wilmer Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21287-9257.
Adler
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002642:Chick Embryo; D018076:DNA, Complementary / Q000235:genetics; D004076:Digoxigenin; D015536:Down-Regulation; D017403:In Situ Hybridization; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000196:embryology*; D016350:Leucine Zippers / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015347:RNA Probes; D012160:Retina / Q000033:anatomy & histology / Q000196:embryology*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics*
D018076:DNA, Complementary; D015347:RNA Probes; D014157:Transcription Factors; D004076:Digoxigenin