[Effect of glycerol-induced acute renal failure in rabbit with Ligusticum wallichii on thromboxane B2, 6-keto-prostaglandin F1 alpha/thromboxane B2].
The effect in preventing and treating glycerol-induced acute renal failure (ARF) in rabbit with Ligusticum wallichii (LW) has been studied. 33 male and female rabbits weighing 2.0-3.0 Kg were divided into three groups randomly: (1) LW treated group. (2) pathological control group and (3) normal control group. The measurement of plasma 6-keto-PGF1 alpha, TXB2 concentration and 6-keto-PGF1 alpha/TXB2 ratio were carried out with radioimmunoassay after 24 hr, 48 hr and 72 hr of ARF. The results showed that plasma TXB2 concentration obviously increased (P < 0.01), 6-keto-PGF1 alpha concentration had no obvious changes (P > 0.05), 6-keto-PGF1 alpha/TXB2 ratio markedly decreased and LW could reduce plasma TXB2 concentration, slightly increase the plasma 6-keto-PGF1 alpha concentration, keep 6-keto-PGF1 alpha/TXB2 ratio in normal level after ARF. It showed that LW could inhibit effectively platelet activation, correct 6-keto-PGF1 alpha/TXB2 imbalance and have a preventing and treating effect for ARF.
Hu
W L
WL
Dept. of Urology, Guangzhou General Hospital of PLA.
Ma
Y J
YJ
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005990:Glycerol; D008297:Male; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood*
D004365:Drugs, Chinese Herbal; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D005990:Glycerol