Preferential hindquarter vasodilation in the hypotension induced by GABA injection into the cisterna magna of conscious rats.
Injection of GABA into the cisterna magna of conscious rats induced a vasodilation in the hindquarter without significant change in the renal and superior mesenteric areas, when arterial pressure and heart rate markedly decreased. This circulatory change indicates that GABA decreased arterial pressure as an effect on the CNS, in particular, through a hindquarter resistance reduction, along with a bradycardia.
Takemoto
Y
Y
Department of Physiology, Hiroshima University School of Medicine, Japan.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology* / Q000502:physiology
D005680:gamma-Aminobutyric Acid