The effects of synthetic thymopoietin on binding of alpha-bungarotoxin to rat neural membranes.
Chemically synthesized bovine thymopoietin I (TPO-I) and thymopoietin II (TPO-II) were evaluated as inhibitors of 125I alpha-Bungarotoxin binding to rat brain neural membranes and found to be over 1,000 x less potent (IC50 = 10 microM) than reported for thymopoietin isolated from bovine thymus.
Jennings
K R
KR
Department of Biology, York University, North York, Ontario, Canada.
Shieh
H M
HM
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002038:Bungarotoxins / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013946:Thymopoietins / Q000138:chemical synthesis / Q000494:pharmacology*
D002038:Bungarotoxins; D011978:Receptors, Nicotinic; D013946:Thymopoietins