title: Synthesis of the metabolites of clentiazem.
abstract: The metabolites of clentiazem in the urine or bile of rats and dogs were investigated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present paper, fourteen reference compounds as shown in Charts 1, 2 and 3 were synthesized to identify the structures of the metabolites in procedures fundamentally similar to those employed in the synthesis of the corresponding metabolites of diltiazem.
authors.affiliation: Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Otsuka
authors.forename: M
authors.initials: M
authors.lastname: Gaino
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Matsuki
authors.forename: M
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000818:Animals; D001711:Biotransformation; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000378:metabolism* / Q000493:pharmacokinetics; D004110:Diltiazem / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
chemical_list: D002121:Calcium Channel Blockers; C056595:clentiazem; D004110:Diltiazem