title: Impact of stereotactic interstitial radiation on brain capillary physiology.
abstract: rCBF, capillary permeability and vascular volume have been measured during the time course of interstitial stereotactic radiosurgery in normal and tumour-bearing dog brain. For rCBF measurement the stable Xenon-CT-technique with a modified Kety-Schmidt equation has been used, and for measurement of blood-to-brain transport of meglumine iothalamate the two-compartment CT-method as developed by Groothuis, which also reflects vascular volume. Anaplastic gliomas had been induced by intracerebral injection of avian sarcoma virus. Radiation sources have been 192-iridium and 198-gold. Both of the isotopes caused spherical blood-brain-barrier lesions with a more than 10-fold blood-to-brain transport increase. These effects occurred earlier and more pronounced with 192-iridium, but much longer lasting with 198-gold. Interstitial radiosurgery of the tumours led to a further increase of capillary permeability. Blood flow was significantly lowered not only within radionecrosis but also in the adjacent brain areas.
authors.affiliation: Abteilung Stereotaktische Neurochirurgie, Neurochirurgische Universitätsklinik Freiburg, Federal Republic of Germany.
authors.forename: P C
authors.initials: PC
authors.lastname: Warnke
authors.forename: F J
authors.initials: FJ
authors.lastname: Hans
authors.forename: C B
authors.initials: CB
authors.lastname: Ostertag
mesh_terms: D000708:Anaplasia / Q000601:surgery; D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects; D001918:Brachytherapy; D001921:Brain / Q000098:blood supply* / Q000528:radiation effects / Q000601:surgery*; D002199:Capillary Permeability / Q000502:physiology* / Q000528:radiation effects*; D002560:Cerebrovascular Circulation / Q000528:radiation effects; D004285:Dogs; D005260:Female; D005910:Glioma / Q000601:surgery; D008297:Male; D016634:Radiosurgery; D012039:Regional Blood Flow / Q000528:radiation effects; D014057:Tomography, X-Ray Computed