[The interaction of human natural killers with target cells of the K562 line and its sublines characterized by multiple drug resistance and thermoresistance].
Target cells, K562 strain and its sublines characterized by multiple drug resistance (MDR) do not differ in their susceptibility to human natural killer cells (NK) but MDR cells are more susceptible to cytotoxic action of lymphokine-activated cells (LAC) and to NK cells in the presence of a selective agent adriamycin. Target cells death is characterized by fragmentation of nuclear DNA. It has been established that K562 thermotolerant subclone is more resistant to NK and LAC than other clones. Heat shock protein synthesis may have a protective impact in target cells death during interaction with NK and LAC cells.
Davtian
T K
TK
Blinova
G I
GI
Ignatova
T N
TN
Aleksanian
Iu T
IuT
Meliksetian
M B
MB
D002450:Cell Communication / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D002467:Cell Nucleus / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D004273:DNA, Neoplasm / Q000276:immunology; D004351:Drug Resistance; D006358:Hot Temperature; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D014407:Tumor Cells, Cultured / Q000276:immunology
D004273:DNA, Neoplasm
Vzaimodeĭstvie estestvennykh killerov cheloveka s kletkami-misheniami linii K562 i ee subliniiami, kharakterizuiushchimisia mnozhestvennoĭ lekarstvennoĭ ustoĭchivost'iu i teploustoĭchivost'iu.