title: The role of fast neutron therapy in unresectable pelvic osteosarcoma: preliminary report.
abstract: Primary osteosarcoma of the pelvic bones represents less than 10% of all osteosarcoma. Despite mutilating surgical procedures or high-dose radiotherapy and neoadjuvant chemotherapy, local failures and distant metastases remain common. The 2-year actuarial survival rate is less than 50% and the disease-free survival is under 20% at 2 years. We report 4 cases of pelvic osteosarcoma treated by a combination of chemotherapy, photon beam and neutron beam radiotherapy. After a median follow-up of 24 months, all 4 patients are alive and disease free.
authors.affiliation: Radiotherapy Department, Centre Léon Bérard, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Carrie
authors.forename: N
authors.initials: N
authors.lastname: Breteau
authors.forename: S
authors.initials: S
authors.lastname: Negrier
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: P
authors.initials: P
authors.lastname: Thiesse
authors.forename: J Y
authors.initials: JY
authors.lastname: Blay
authors.forename: M
authors.initials: M
authors.lastname: Clavel
authors.forename: T
authors.initials: T
authors.lastname: Philip
authors.forename: P
authors.initials: P
authors.lastname: Biron
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005214:Fast Neutrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000532:radiotherapy*; D010384:Pelvic Bones; D017785:Photons / Q000627:therapeutic use