Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection.
The ability of conjugated linoleic acid to prevent endotoxin-induced growth suppression was examined. Mice fed a basal diet or diet with 0.5% fish oil lost twice as much body weight after endotoxin injection than mice fed conjugated linoleic acid. By 72 hours post injection, mice fed conjugated linoleic acid had body weights similar to vehicle injected controls; however, body weights of basal and fish oil fed mice injected with endotoxin were reduced. Conjugated linoleic acid prevented anorexia from endotoxin injection. Splenocyte blastogenesis was increased by conjugated linoleic acid.
Miller
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Poultry Science Dept., U.W. Madison 53706.
Park
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Pariza
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Cook
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ME
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002645:Chickens; D004041:Dietary Fats / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004926:Escherichia coli; D005260:Female; D005395:Fish Oils / Q000494:pharmacology; D008041:Linoleic Acids / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D014280:Triglycerides; D015431:Weight Loss / Q000187:drug effects
D004041:Dietary Fats; D004731:Endotoxins; D005395:Fish Oils; D008041:Linoleic Acids; D008070:Lipopolysaccharides; D014280:Triglycerides; C033266:Menhaden oil