title: Disomic locus content mapping.
abstract: A linear genetic map may be constructed from segregation of markers in DNA fragments broken by radiation or shearing and/or incorporated into a vector: this is locus content mapping. Theory for monosomic locus content mapping is extended to disomy, making the phase of heterozygous markers informative for linkage and each clone potentially informative for every chromosome. Because there is no interference among breaks and phase may be reliable inferred for all heterozygous loci, multiple pairwise mapping is especially appropriate.
authors.affiliation: Department of Child Health, University of Southampton, Princess Anne Hospital, United Kingdom.
authors.forename: N E
authors.initials: NE
authors.lastname: Morton
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D008040:Genetic Linkage; D006579:Heterozygote; D008957:Models, Genetic; D009006:Monosomy