title: Serum soluble tumour necrosis factor receptor 55 is increased in patients with haematological neoplasias and is associated with immune activation and weight loss.
abstract: Enhanced concentrations of soluble forms of the receptor for tumour necrosis factor (TNF)-alpha have been detected in the serum of cancer patients. We determined serum concentrations of soluble TNF receptor p55 (sTNF-R55) in patients with haematological neoplasias, 50 patients suffering from non-Hodgkin's lymphoma (n = 35), Hodgkin's disease (n = 10) and multiple myeloma (n = 5). Compared with healthy controls and with patients with potential thyroid disease, significantly elevated concentrations of sTNF-R55 were found (mean +/- standard error: 2.68 +/- 0.22 vs. 1.23 +/- 0.21 ng/ml, P < 0.0001 and 2.18 +/- 0.32 ng/ml, P = 0.03). Likewise, neopterin concentrations were raised (19.6 +/- 3.66 vs. 5.3 +/- 0.25 nmol/l in controls, P < 0.0001). We found a significant correlation between sTNF-R55 and neopterin concentrations (Rs = 0.544, P < 0.001). Patients with weight loss showed higher sTNF-R55 concentrations than patients with stable weight. Our results confirm the relevance of sTNF-R55 concentrations in serum of patients with cancer.
authors.affiliation: Clinic of Internal Medicine, Kantonsspital Liestal, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Denz
authors.forename: B
authors.initials: B
authors.lastname: Orth
authors.forename: G
authors.initials: G
authors.lastname: Weiss
authors.forename: H
authors.initials: H
authors.lastname: Gallati
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
authors.forename: P
authors.initials: P
authors.lastname: Huber
authors.forename: H
authors.initials: H
authors.lastname: Wachter
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
mesh_terms: D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D003602:Cytotoxicity, Immunologic; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000276:immunology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000276:immunology; D008297:Male; D009101:Multiple Myeloma / Q000097:blood* / Q000276:immunology; D019798:Neopterin; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D015431:Weight Loss
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D001708:Biopterins; D019798:Neopterin