Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice.
Changes in immunoreactive somatostatin (SOM) and cholecystokinin (CCK-8) levels in the cerebellum and cerebrum were investigated in three types of genetically-determined ataxic mutant mice: rolling mouse Nagoya (RMN), weaver, and Purkinje cell degeneration (PCD) mice. The cerebellar pathology in each of these types differs. The concentration of both SOM and CCK-8 (ng/mg weight) was significantly higher in the cerebellum and the cerebrum of the three types of ataxic mutant mice than in these regions in the respective controls. SOM and CCK-8 content (ng/organ) was significantly higher in PCD and RMN than in controls but this was not in the weaver mice. The possible involvement of both peptides in manifestations of ataxia is discussed.
Matsui
K
K
National Institute of Neuroscience, NCNP, Tokyo, Japan.
Masui
A
A
Kato
N
N
Adachi
K
K
D000818:Animals; D001259:Ataxia / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin; D002766:Cholecystokinin