Successful treatment for a metastatic supratentorial malignant rhabdoid tumor.
The case of a boy with a familial history of Rendu-Osler disease, who successively developed a cerebellar pilocytic astrocytoma (at 3 years of age) and a metastatic supratentorial malignant rhabdoid tumor (at the age of 12 years) is reported. After a complete surgical removal, the CSF was cleared by 4 courses of chemotherapy, and the child received a craniospinal irradiation. He is currently alive and well 19 months after completion of the treatment. The authors discuss the ethiopathogeny of such intracranial tumors and argue for aggressive treatment.
Bouffet
E
E
Pediatric Unit, Centre Léon Bérard, Lyon, France.
Frappaz
D
D
Dolbeau
D
D
Sobol
H
H
Jouvet
A
A
Carrie
C
C
Pondarre
C
C
Brunat-Mentigny
M
M
Philip
T
T
Mottolese
C
C
D001254:Astrocytoma / Q000601:surgery; D002528:Cerebellar Neoplasms / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000628:therapy*; D010375:Pedigree; D018335:Rhabdoid Tumor / Q000556:secondary / Q000628:therapy*; D015173:Supratentorial Neoplasms / Q000556:secondary / Q000628:therapy*