Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma.
We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.
Hashimoto
S
S
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Imai
K
K
Kobayashi
T
T
Amemiya
E
E
Takahashi
Y
Y
Tomita
Y
Y
Iwata
T
T
Suguro
H
H
Yamaguchi
M
M
Yachi
A
A
D000328:Adult; D001249:Asthma / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood; D018799:Intercellular Adhesion Molecule-1; D008875:Middle Aged
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1