title: In vitro comparison of E4868, a new trifluoroquinolone, with ciprofloxacin and temafloxacin tested against 5192 recent clinical isolates from five medical centers.
abstract: The in vitro activity of E4868 was compared with that of ciprofloxacin and temafloxacin in a multicenter study. More than 90% of Enterobacteriaceae and 82% of the 651 isolates of Pseudomonas aeruginosa, as well as > 95% of the oxacillin-susceptible staphylococci, 100% of the beta-hemolytic streptococci, and 76% of the enterococcal isolates were susceptible to E4868 (minimum inhibitory concentrations, < or = 2 micrograms/ml). E4868 was generally equivalent or slightly less active than ciprofloxacin against the Enterobacteriaceae and Pseudomonas and more active against staphylococci and beta-hemolytic streptococci. The activity of E4868 was generally equivalent to or slightly greater than that of temafloxacin against all major groups of organisms.
authors.affiliation: Department of Pathology, Washington University Medical Center, St. Louis, Missouri.
authors.forename: P R
authors.initials: PR
authors.lastname: Murray
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
authors.forename: E H
authors.initials: EH
authors.lastname: Gerlach
authors.forename: S D
authors.initials: SD
authors.lastname: Allen
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D024841:Fluoroquinolones; D006095:Gram-Positive Cocci / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C081131:E-4868; C054745:temafloxacin; D002939:Ciprofloxacin