Modulation of MHC class II expression in the absence of lymphocytic infiltrates in Alzheimer's retinae.
This study describes the expression of MHC class II antigens in retinal flat mounts from normal donors and patients with Alzheimer's disease (AD). We confirm previous observations of MHC class II immunoreactivity on microglia in normal retinae, while observing insignificant levels of reactivity on endothelial cells (EC). A significantly increased level of MHC class II expression was detected in AD retinae. This increased immunoreactivity was found to occur in the absence of lymphocytic infiltrates, suggesting that the pathogenesis of AD in the retina may be distinct from that reported to occur in some regions of the brain. MHC class II expression, measured using computerized optical densitometry, appeared to be increased principally as a result of induced MHC class II immunoreactivity on EC. Ramified microglia and perivascular macrophages, although hypertrophied, appeared to show unchanged levels of MHC class II expression. These findings are consistent with earlier suggestions that both aberrant MHC class II expression and suppressor activity of resident macrophages may restrict immune responses.
Liew
S C
SC
Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Australia.
Penfold
P L
PL
Provis
J M
JM
Madigan
M C
MC
Billson
F A
FA
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D000544:Alzheimer Disease / Q000276:immunology* / Q000473:pathology; D006681:HLA-D Antigens / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D017628:Microglia / Q000166:cytology / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D012016:Reference Values; D012160:Retina / Q000166:cytology / Q000276:immunology* / Q000473:pathology
D006681:HLA-D Antigens