Psychometric analysis in children with mental retardation due to perinatal hypoxia treated with fibroblast growth factor (FGF) and showing improvement in mental development.
Basic fibroblast growth factor (bFGF) has shown a neurotrophic effect in the neurons of several CNS areas. In vivo, it contributes to restore neurochemical and morphological deficits in different rodent models of brain damage, including rats with brain damage induced by hypoxia/ischemia when FGF was intramuscularly (i.m.) administered. Toxicological and immunological studies performed in rats, mice and volunteers showed no evidence of side-effects. Bovine FGF was i.m. administered in children with mental retardation caused by perinatal hypoxia, aged 1-15 years, at dosages of 0.4 or 0.28 microgram kg-1, once or twice a month, over 7-12 months. Group A [n = 12; 6 treated (T), 6 controls (Ct)], group B (n = 16; 8 T, 8 Ct) and group C (n = 67; 45 T, 22 Ct) were evaluated with the P. A. R. scale, the WISC-RM and the Gesell scale, respectively. Development increased significantly in treated children from groups A (P < 0.02) and C (P < 0.001), and IQ rose by more than 10 points (P < 0.001) in group B patients.
Aguilar
L C
LC
Instituto de Investigaciones en Neuroplasticidad y Desarrollo Celular, Guadalajara, Jal. Mexico.
Islas
A
A
Rosique
P
P
Hernandez
B
B
Portillo
E
E
Herrera
J M
JM
Cortes
R
R
Cruz
S
S
Alfaro
F
F
Martin
R
R
D000293:Adolescent; D000818:Animals; D001921:Brain / Q000196:embryology; D002417:Cattle; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005346:Fibroblast Growth Factors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications*; D066298:In Vitro Techniques; D007223:Infant; D007273:Injections, Intramuscular; D008607:Intellectual Disability / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014888:Wechsler Scales
D005346:Fibroblast Growth Factors