Resistance to intestinal parasites during murine AIDS: role of alcohol and nutrition in immune dysfunction.
A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.
Watson
R R
RR
Department of Family and Community Medicine, University of Arizona, Tucson 85724.
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000428:Alcohol Drinking / Q000276:immunology*; D000818:Animals; D003457:Cryptosporidiosis / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004032:Diet / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D005873:Giardiasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007411:Intestinal Diseases, Parasitic / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*
D016207:Cytokines