title: Effect of transdermal oestradiol on the haemostatic balance of menopausal women.
abstract: OBJECTIVE
  To determine the effect of transdermal oestrogen replacement therapy on the haemostatic balance of menopausal women.
  
  
  METHODS
  Open, parallel group, prospective study.
  
  
  METHODS
  Three hospital-based menopause clinics.
  
  
  METHODS
  Fifty-two postmenopausal women receiving transdermal hormone replacement therapy (Estrapak 50) for 6 months. Comparison group of 48 untreated postmenopausal women studied in parallel.
  
  
  METHODS
  Changes in platelet number, plasma concentrations of coagulation factors and their natural inhibitors, fibrinolytic activity, and rheological parameters.
  
  
  RESULTS
  Estrapak 50 had no significant thrombophilic effect on any of the outcome measures.
  
  
  CONCLUSIONS
  The haemostatic balance and thus the risk of thrombosis would not appear to be upset by this dose of transdermal oestrogen.
authors.affiliation: Midlands Menopause Study Group: Birmingham Maternity Hospital, UK.
authors.forename: J
authors.initials: J
authors.lastname: Fox
authors.forename: A J
authors.initials: AJ
authors.lastname: George
authors.forename: J R
authors.initials: JR
authors.lastname: Newton
authors.forename: A D
authors.initials: AD
authors.lastname: Parsons
authors.forename: G K
authors.initials: GK
authors.lastname: Stuart
authors.forename: J
authors.initials: J
authors.lastname: Stuart
authors.forename: D W
authors.initials: DW
authors.lastname: Sturdee
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000032:analysis / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011446:Prospective Studies
chemical_list: D001779:Blood Coagulation Factors; D004958:Estradiol