title: Retrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Côte d'Ivoire.
abstract: OBJECTIVE
  To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children.
  
  
  METHODS
  Retrospective cohort study with cross sectional study of concordance for HIV antibodies.
  
  
  METHODS
  Hospital, tuberculosis clinic, and maternal and child health centre in Abidjan, Côte d'Ivoire, west Africa.
  
  
  METHODS
  986 women who had had a total of 2758 pregnancies since 1980. The last born children of 194 of these women.
  
  
  METHODS
  Pregnancy outcomes; mortality for all children born since 1980; and outcome for last born children. Serological concordance between mothers and last born children.
  
  
  RESULTS
  Women with HIV-1 and HIV-2 infections had higher rates of spontaneous abortion and stillbirth than uninfected women (86/769 in HIV-1 positive women, 48/421 in HIV-2 positive, 31/234 in dually reactive, and 96/1131 in uninfected). Compared with children born to uninfected mothers (mortality 10.3%), greater proportions of children of HIV-1 positive (20.6%) and dually reactive (20.3%) mothers had died; mortality in children of HIV-2 infected women (13.1%) was not significantly increased. Infant mortalities for the last born children of HIV-1 positive, dually reactive, HIV-2 positive, and seronegative women were, respectively, 133, 82, 32, and 40 per 1000 live births. Nine of 77 last born children of HIV-1 positive mothers were concordantly seropositive compared with none of 21 children of HIV-2 infected mothers.
  
  
  CONCLUSIONS
  Maternal HIV-2 infection has less influence on child survival than infection with HIV-1, probably because of a lower vertical transmission rate.
authors.affiliation: Projet RETRO-CI, Abidjan, Côte d'Ivoire.
authors.forename: K M
authors.initials: KM
authors.lastname: De Cock
authors.forename: F
authors.initials: F
authors.lastname: Zadi
authors.forename: G
authors.initials: G
authors.lastname: Adjorlolo
authors.forename: M O
authors.initials: MO
authors.lastname: Diallo
authors.forename: M
authors.initials: M
authors.lastname: Sassan-Morokro
authors.forename: E
authors.initials: E
authors.lastname: Ekpini
authors.forename: T
authors.initials: T
authors.lastname: Sibailly
authors.forename: R
authors.initials: R
authors.lastname: Doorly
authors.forename: V
authors.initials: V
authors.lastname: Batter
authors.forename: K
authors.initials: K
authors.lastname: Brattegaard
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D007560:Cote d'Ivoire / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000401:mortality; D015497:HIV-1; D015498:HIV-2; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000401:mortality; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D015996:Survival Rate