Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.
We describe the synthesis and characterization of novel phosphorothioate-methylphosphonate backbone-modified oligodeoxynucleotide co-polymers. These may have potential use as antisense constructs.
Zhou
L
L
Pharmacology Department, Georgetown University Medical Center, Washington, DC 20007.
Morocho
A M
AM
Chen
B C
BC
Cohen
J S
JS
D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000138:chemical synthesis*; D013873:Thionucleotides / Q000138:chemical synthesis*
D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D013873:Thionucleotides