The effect of granulocyte-macrophage colony stimulating factor on paroxysmal nocturnal hemoglobinuria: a case report.
This case report concerns a woman thought to have a low blood count myelodysplastic syndrome who responded poorly to cytosine arabinoside. She was treated with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and had an adverse reaction resembling a capillary leak syndrome. Later on, an episode of post-transfusion hemoglobinuria led to the correct diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). This case report suggests an adverse effect of GM-CSF on PNH.
Webb
D I
DI
Pathology Department, Providence Hospital, Anchorage, Alaska 99508.
Bundtzen
J L
JL
D000368:Aged; D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000628:therapy; D012890:Sleep; D065227:Transfusion Reaction
D016178:Granulocyte-Macrophage Colony-Stimulating Factor