[Tuftsin-like peptides from a C-reactive protein molecule as regulators of lymphocyte proliferation].
Influence of synthetic peptides from human C-reactive protein (CRP) on proliferation of intact and mitogen stimulated peripheral blood lymphocytes was studied. Effect of the tetra-peptides from CRP was similar to that of tuftsin Thr-Lys-Pro-Arg. All the peptides studied did not increase the 3H-thymidine incorporation into the resting lymphocytes but accelerated it after mitogen stimulation. The peptides efficiency depended on T- or B-specificity of mitogens.
Polevshchikov
A V
AV
Nazarov
P G
PG
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D002097:C-Reactive Protein / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008934:Mitogens; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D014405:Tuftsin / Q000737:chemistry / Q000494:pharmacology*
D008934:Mitogens; D010455:Peptides; D002097:C-Reactive Protein; D014405:Tuftsin
Taftsinopodobnye peptidy iz molekuly C-reaktivnogo belka kak moduliatory proliferatsii limfotsitov.