title: Oral sotalol reduces the incidence of atrial fibrillation after coronary artery bypass surgery.
abstract: Episodes of atrial fibrillation or flutter frequently complicate the postoperative course after coronary bypass surgery. A hundred and one patients undergoing coronary artery bypass surgery were randomized to oral pre- and postoperative treatment with sotalol, a non-selective beta-blocking agent with class-III antiarrhythmic properties (50 patients), or to half the preoperative beta-blocking dose according to the routine of the department (51 patients). Thus, there was no equipotency regarding beta blockade in the two groups. The incidence of atrial fibrillation was 10% in the sotalol group and 29% in the comparison group, p = 0.028. In 10% of the sotalol patients the dose had to be reduced or stopped compared to in none the group given routine treatment. The patients who developed atrial fibrillation were older, but otherwise there was no statistically significant difference between the two groups. Sotalol was effective in reducing the incidence of atrial fibrillation. However, careful titration of the optimal dose should be performed in order to avoid side effects of the beta blockade.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Sahlgren's University Hospital, Göteborg, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Nyström
authors.forename: N
authors.initials: N
authors.lastname: Edvardsson
authors.forename: H
authors.initials: H
authors.lastname: Berggren
authors.forename: G P
authors.initials: GP
authors.lastname: Pizzarelli
authors.forename: K
authors.initials: K
authors.lastname: Rådegran
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000517:prevention & control*; D016009:Chi-Square Distribution; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011300:Preoperative Care / Q000706:statistics & numerical data; D012737:Sex Factors; D013015:Sotalol / Q000008:administration & dosage*
chemical_list: D000319:Adrenergic beta-Antagonists; D013015:Sotalol