title: Temporary change of compound action potential amplitude after intense sound exposure.
abstract: Intense sound induces a temporary or permanent threshold shift. The aim of this study is to make an experimental model for temporary threshold shift (TTS) using guinea pigs. In this study, two kinds of sound exposure were used for inducing a threshold shift in the guinea pig; one of 110 dB SPL at 10 kHz for 10 min and the other of 120 dB SPL at 10 kHz for 5 min. The former condition produced different levels of reduction in compound action potential (CAP) immediately after sound exposure and different steady levels of CAP amplitude after recovery (within 120 min) in 10 guinea pigs. The latter condition produced a total loss of CAP amplitude immediately after sound exposure in 8 of 9 guinea pigs, and this condition continued for 120 min in 7 of the 9 guinea pigs. Additionally, in 2 of 3 guinea pigs which were exposed the sound of 120 dB SPL at 10 kHz for 5 min, the CAP amplitudes were almost the same as those of control animals 1 day after the exposure. One the basis of these results, we consider the sound of 120 dB SPL at 10 kHz for 5 min to be the optimal intensity and frequency of sound and duration of exposure for producing a TTS in the guinea pig.
authors.affiliation: Department of Neurophysiology, Tokyo Medical and Dental University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Homma
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: A
authors.initials: A
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Tamura
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000503:physiopathology*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000502:physiology / Q000503:physiopathology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000166:cytology / Q000503:physiopathology