title: Radioiodine uptake by squamous-cell carcinoma of the lung.
abstract: A patient with a history of total thyroidectomy for papillary carcinoma showed a solitary hot spot in the chest on post-therapy radioiodine imaging. Subsequent evaluation demonstrated that this lesion was a primary squamous-cell lung cancer. Our case illustrates a rare but important differential diagnosis from lung metastasis of thyroid cancer in 131I scintigraphy. Alternatively, this "aberrant uptake" might be a rather common phenomenon for lung neoplasms, although the underlying mechanism is not yet known. Future experimental studies might lead to a new application of radioiodine imaging in pulmonary oncology.
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Misaki
authors.forename: R
authors.initials: R
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Kasagi
authors.forename: Y
authors.initials: Y
authors.lastname: Matsui
authors.forename: J
authors.initials: J
authors.lastname: Konishi
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000000981:diagnostic imaging / Q000556:secondary; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D007457:Iodine Radioisotopes; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000473:pathology
chemical_list: D007457:Iodine Radioisotopes