Mixed connective tissue disease and Sjögren's syndrome, accompanied by HTLV-I infection.
A 48-year-old Japanese woman with mixed connective tissue disease (MCTD) and Sjögren's syndrome (SjS) was a carrier of HTLV-I and had anti-HTLV-I antibodies in her serum. Moreover, her peripheral blood lymphocytes contained proviral DNA for the pX region of HTLV-I as detected by the polymerase chain reaction. An immunohistological study was performed on her minor salivary gland to detect gene products of HTLV-I (P19 and P28 proteins); specific staining was demonstrated only in the epithelium of the salivary ducts. HTLV-I and its associated immune dysfunction may be responsible for MCTD and SjS in this patient.
Matsumoto
Y
Y
Second Department of Internal Medicine, Nagoya City University Medical School, Japan.
Muramatsu
M O
MO
Sato
K
K
D004279:DNA, Viral / Q000235:genetics; D015480:Deltaretrovirus Antibodies / Q000097:blood; D004848:Epithelium / Q000737:chemistry; D005260:Female; D015683:Gene Products, gag / Q000032:analysis; D015486:HTLV-I Antigens / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications*; D006579:Heterozygote; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000209:etiology*; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D015682:Retroviridae Proteins, Oncogenic / Q000032:analysis; D012469:Salivary Glands / Q000737:chemistry; D012859:Sjogren's Syndrome / Q000209:etiology*; D054301:gag Gene Products, Human Immunodeficiency Virus
D004279:DNA, Viral; D015480:Deltaretrovirus Antibodies; D015683:Gene Products, gag; D015486:HTLV-I Antigens; D015682:Retroviridae Proteins, Oncogenic; D054301:gag Gene Products, Human Immunodeficiency Virus; C060955:p19 protein, Human T-lymphotropic virus 1