[Positive modulating action of shengmaisan with Astragalus membranaceus on anti-tumor activity of LAK cells].
Enhancing the anti-tumor activity of LAK cells is one of problems which are expected to be solved in tumor clinic at present. The effects of Shengmaisan with Astragalus membranaceus (SMAM) on anti-tumor activity of LAK cells with the 3H release assay were studied. The LAK cells taken from 43 persons showed obvious killing activity to acute leukemia cells from 8 patients in different types. The results showed that the activity of LAK cells could be enhanced markedly by the synergic action of SMAM in proper concentration (100 micrograms/ml) with IL-2. The effect of ginsenoside with appropriate concentration (10 micrograms/ml) was slightly better than that of SMAM. The treatment for malignant tumor using SMAM assisting LAK cells could replace the application of some cell factors which were expensive and toxic at present.
Zhao
T H
TH
Chengde Medical College.
D000328:Adult; D027885:Astragalus propinquus; D002675:Child, Preschool; D003602:Cytotoxicity, Immunologic; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D036145:Ginsenosides; D006801:Humans; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000276:immunology; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects* / Q000276:immunology; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012503:Saponins / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D007376:Interleukin-2; D012503:Saponins