Enhancement of Y-maze learning by piracetam, 2-thio-1-pyrrolidine-acetamide and 2-thio-1-pyrrolidine-thio-acetamide in rats.
Learning of rats given either piracetam, 2-thio-1-pyrrolidine-acetamide (thioacet) or 2-thio-1-pyrrolidine-thio-acetamide (thiothio) was studied in order to investigate nootropic effects of the compounds. Learning ability was measured using a Y-maze with water reward for the correct choice in a black-white discrimination task. Thioacet and thiothio enhanced learning ability of the rats at doses that were 2.5-10 times lower than those required for obtaining nootropic effects of piracetam. Thus the thio-derivatives of piracetam might be of value for studying mechanisms of action of nootropic drugs.
Soerensen
J B
JB
Department of Organic Chemistry, University of Aarhus, Denmark.
Smith
D F
DF
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D010889:Piracetam / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
D011619:Psychotropic Drugs; C086137:2-thioxo-1-pyrrolidinethioacetamide; C086136:2-thioxo-1-pyrrolidineacetamide; D010889:Piracetam