title: The effects of antibiotics and steroids on the carriage of vaginal bacteria into the uterus during insertion of intra-uterine monofilaments in the guinea-pig.
abstract: The effects of systemic norethisterone acetate and oxytetracycline hydrochloride on the levels of vaginal microorganisms found in the uterus after the insertion of transcervical, intra-uterine monofilaments in the guinea-pig were determined. The results indicated that bacteria were transferred to the uterus from the vagina during the insertion process and, in the presence of an intra-uterine substrate, persisted for up to 6 months. Daily treatment with norethisterone acetate or oxytetracycline hydrochloride whilst the monofilament was in-situ failed to reduce the bacterial numbers in the uterus. Similarly, daily treatment with oxytetracycline hydrochloride for the 5 days before monofilament insertion had no effect on these bacteria.
authors.affiliation: Department of Pharmacy, University of Brighton, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Malhi
authors.forename: P R
authors.initials: PR
authors.lastname: Gard
authors.forename: G W
authors.initials: GW
authors.lastname: Hanlon
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D015169:Colony Count, Microbial; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007434:Intrauterine Devices / Q000009:adverse effects*; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D010118:Oxytetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology*
chemical_list: D045167:Progesterone Congeners; D000077563:Norethindrone Acetate; D009640:Norethindrone; D010118:Oxytetracycline