title: [Efficacy of a powder inhaler (Turbuhaler) in moderate asthmatic crises in children].
abstract: The use of a metered dose inhaler can be difficult in children, and requires the juxtaposition of an inhalation chamber. Powder inhalers offer different means of administration and are simpler to use and can be easily carried in the pocket or in a school satchel. The aim of this study is to assess the use of a beta-2-mimetic powder inhaler (Bricanyl Turbuhaler) in children presenting with an exacerbation of asthma. Thirty children aged from 4 to 14 years were included in an open random study in parallel groups. After a baseline measure of pulmonary function, the children inhaled 500 microgram of powdered terbutaline, or with metered dose aerosol attached to a spacer device (Nebuhaler). A significant bronchodilatation was apparent in the two groups of children which was measured at 15 and 30 minutes after the inhalation of the drug (measures of peak flow and forced expiratory volume in one second and of specific airways resistance were made). The bronchodilator response was similar whatever the method of inhalation. Although the inspiratory flow is decreased in an exacerbation this work shows that it is possible to advise the use of a powder inhaler in children presenting with a moderate exacerbation of asthma.
authors.affiliation: Laboratoire EFR, Hôpital des Enfants-Malades, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Rufin
authors.forename: M R
authors.initials: MR
authors.lastname: Benoist
authors.forename: P
authors.initials: P
authors.lastname: Panqueva
authors.forename: J J
authors.initials: JJ
authors.lastname: Brouard
authors.forename: J
authors.initials: J
authors.lastname: De Blic
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D000293:Adolescent; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D010366:Peak Expiratory Flow Rate; D011208:Powders; D013726:Terbutaline / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000336:Aerosols; D011208:Powders; D013726:Terbutaline
vernacular_title: Efficacité d'un inhalateur de poudre (Turbuhaler) dans la crise d'asthme modérée de l'enfant.