title: Biochemical and genetic indices of marine pollution in Spanish littoral.
abstract: Increased activities of several detoxifying and antioxidant enzymes were detected in mollusc and fish from Spanish littoral areas with high metal contents. Ethanolic extracts from molluscs contained direct-acting and polar genotoxins of oxidative type, which were detected by strain TA102 of S. typhimurium and catalase-deficient strains of E. coli. Animals from contaminated sites contained less genotoxins than those from control areas. Polluted fishes displayed highly induced cytochrome P-450 activity and increased promutagen activation capabilities. In addition, specific forms of glutathione transferase and superoxide dismutase were induced, particularly highly acidic forms.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Ariza
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Lara
authors.forename: P
authors.initials: P
authors.lastname: Pascual
authors.forename: J R
authors.initials: JR
authors.lastname: Pedrajas
authors.forename: N
authors.initials: N
authors.lastname: Abril
authors.forename: G
authors.initials: G
authors.lastname: Dorado
authors.forename: F
authors.initials: F
authors.lastname: Toribio
authors.forename: J A
authors.initials: JA
authors.lastname: Bárcena
authors.forename: J
authors.initials: J
authors.lastname: Peinado
authors.forename: C
authors.initials: C
authors.lastname: Pueyo
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D005399:Fishes / Q000378:metabolism*; D008670:Metals / Q000032:analysis; D008974:Mollusca / Q000187:drug effects / Q000201:enzymology*; D009152:Mutagenicity Tests; D010088:Oxidoreductases / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects; D012623:Seawater; D013030:Spain; D014877:Water Pollution, Chemical / Q000032:analysis*
chemical_list: D008670:Metals; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases