title: Effect of vitreous fluidity on the measurement of blood-retinal barrier permeability using contrast-enhanced MRI.
abstract: Breakdown of the blood-retinal barrier (BRB), frequently an early clinical sign in retinopathy, can be accurately determined using contrast-enhanced MRI. However, increased vitreous fluidity with age and disease may affect the accuracy of the MRI method. We compared the permeability surface area product per area of leaky retina in eyes with normal vitreous (5.42 +/- 0.48 x 10(-4) cm/min, mean +/- SEM, n = 5) to the contralateral gas-compressed vitrectomized eyes (5.41 +/- 0.54 x 10(-4) cm/min, n = 5). The effect of vitrectomy was not significant (P = 0.325) using a Wilcoxon matched pairs signed rank test on the signed differences of the PS' values.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-8592.
authors.forename: B A
authors.initials: BA
authors.lastname: Berkowitz
authors.forename: C A
authors.initials: CA
authors.lastname: Wilson
authors.forename: P S
authors.initials: PS
authors.lastname: Tofts
authors.forename: R M
authors.initials: RM
authors.lastname: Peshock
mesh_terms: D000818:Animals; D001813:Blood-Retinal Barrier; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010539:Permeability; D011817:Rabbits; D014821:Vitrectomy; D014822:Vitreous Body / Q000502:physiology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA