Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria.
Anaerobic incubation of strychnine N-oxide with human intestinal bacteria resulted in its transformation to strychnine and 16-hydroxystrychnine. Similarly, brucine N-oxide was transformed to brucine and 16-hydroxybrucine.
el-Mekkawy
S
S
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University.
Meselhy
M R
MR
Kawata
Y
Y
Kadota
S
S
Hattori
M
M
Namba
T
T
D001421:Bacteria, Anaerobic / Q000378:metabolism*; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D015394:Molecular Structure; D013331:Strychnine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D003497:Cyclic N-Oxides; C083067:brucine N-oxide; C083068:strychnine N-oxide; D013331:Strychnine