title: Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea.
abstract: In experimental immunogenic keratitis, provoked in rabbits by intracorneal injection of 20 microliters of human serum albumin (HSA), various anti-inflammatory agents were studied in their effects on corneal edema, neovascularisation and leukocyte infiltration. Prophylactic treatment with a corticosteroid completely prevented the occurrence of keratitis. Nonsteroidal anti-inflammatory drugs such as a cyclooxygenase inhibitor partly prevented neovascularisation and corneal edema, a lipoxygenase inhibitor, a leukotriene antagonist or platelet-activating factor (PAF)-antagonist BN 52021 partially prevented mainly leukocyte infiltration. Prophylactic topical treatment with the poly-unsaturated fatty acids eicosapentaenoic acid and columbinic acid or a dietary supplement with fish oil showed less symptoms of keratitis in all respects.
authors.affiliation: The Netherlands Ophthalmic Research Institute, Amsterdam.
authors.forename: N J
authors.initials: NJ
authors.lastname: van Haeringen
authors.forename: N L
authors.initials: NL
authors.lastname: Verbey
authors.forename: J L
authors.initials: JL
authors.lastname: van Delft
mesh_terms: D000818:Animals; D002867:Chromones / Q000627:therapeutic use; D004224:Diterpenes; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use; D005469:Fluorometholone / Q000627:therapeutic use; D046934:Ginkgolides; D007634:Keratitis / Q000378:metabolism* / Q000517:prevention & control; D007783:Lactones / Q000627:therapeutic use; D008042:Linolenic Acids / Q000627:therapeutic use; D008055:Lipids / Q000037:antagonists & inhibitors*; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011817:Rabbits; D013189:SRS-A / Q000037:antagonists & inhibitors; D013496:Suprofen / Q000627:therapeutic use
chemical_list: D002867:Chromones; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D008042:Linolenic Acids; D008055:Lipids; D016859:Lipoxygenase Inhibitors; D010972:Platelet Activating Factor; D013189:SRS-A; C034302:5,9,12-octadecatrienoic acid; C052027:SC 39070; D013496:Suprofen; D015118:Eicosapentaenoic Acid; C045856:ginkgolide B; D005469:Fluorometholone