title: [Immunodeficiency in The Netherlands: clinical and immunological survey, 1970-1983. Interfacultaire werkgroep Immunodeficiëntie].
abstract: OBJECTIVE
  Inventory of patients with immunodeficiency in the Netherlands.
  
  
  METHODS
  Retrospective over the period 1970-1983.
  
  
  METHODS
  Dutch Working Group on Immunodeficiency, University Children's Hospital, 'Het Wilhelmina Kinderziekenhuis', Utrecht.
  
  
  METHODS
  A questionnaire with specific information on immunodeficient patients was completed by clinical members of the Working Group i.e. paediatricians and internists. Diagnosis of the immunodeficiency was according to WHO recommendations.
  
  
  RESULTS
  The data of 336 patients could be included and analysed. Defects in humoral immunity were the most common (62.9%), followed by combined defects (18.75%), T cell defects (7.4%), phagocytic disorders (6.8%) and complement component deficiencies (2.7%). Sixty-two patients (15.5%) died, notably those with combined T and B cell defects, selective T cell defects and those with immunodeficiency based on DNA repair defects. Autoimmunity was relatively frequent in immunodeficiency (7.7%) as was cancer (2.7%).
  
  
  CONCLUSIONS
  Results were similar to those of other European countries.
authors.affiliation: Interfacultaire werkgroep Immunodeficiëntie, Wilhelmina Kinderziekenhuis, afd. Immunologie, Utrecht.
authors.forename: B J
authors.initials: BJ
authors.lastname: Zegers
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: R S
authors.initials: RS
authors.lastname: Weening
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
authors.forename: J M
authors.initials: JM
authors.lastname: Vossen
mesh_terms: D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology; D003165:Complement System Proteins / Q000172:deficiency; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010587:Phagocytosis; D012189:Retrospective Studies
chemical_list: D003165:Complement System Proteins
vernacular_title: Immuundeficiëntie in Nederland: klinische en immunologische inventarisatie, 1970-1983.