Injection of an aromatase inhibitor after the critical period of sexual differentiation.
We have investigated the possible role of the second week of life in the differentiation of sexually dimorphic behaviours, dependent on the androgenic aromatization, and its possible relationship with the serotonergic systems. For this purpose, 5 mg/kg of a suspension of an aromatase inhibitor, LY43578, has been intraventricularly injected to males on day 12 of life. Studies have been made in adulthood on exploratory and motor activities, anxiety, sexual motivation, and sexual performance. Indoleamine levels in the hypothalamus and corpus striatum have been measured. Sexual behaviour, exploration, and serotonergic metabolism were not affected by the treatment. Sex partner preference and anxiety in the plus-maze showed a feminized tendency in the treated group that, however, did not reach statistical significance. From these results we have confirmed the restriction of the critical period of androgenic aromatization for the organization of reproductive and exploratory behaviour.
Gonzalez
M I
MI
Departamento de Biologia Animal II (Fisiologia Animal), Facultad de Ciencias Biologicas, Universidad Complutense, Madrid, Spain.
Leret
M L
ML
D000818:Animals; D001007:Anxiety / Q000523:psychology; D001141:Aromatase / Q000008:administration & dosage / Q000494:pharmacology; D047072:Aromatase Inhibitors; D015306:Biogenic Monoamines / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011187:Posture; D011743:Pyrimidines; D051381:Rats; D017208:Rats, Wistar; D012733:Sex Differentiation / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects
D047072:Aromatase Inhibitors; D015306:Biogenic Monoamines; D011743:Pyrimidines; C085949:LY 43578; D001141:Aromatase