title: [The development of a new experimental model of pneumocystosis].
abstract: The corticosteroid tricort-40 (triamcinolone acetonide) was found to induce the reactivation of endogenous pneumocystic injection caused by P. carinii in Wistar rats given 5-9 infections subcutaneously in median doses of 0.5-4.0 mg/kg at 6-22 days intervals each. Manifest P. carinii infection in the animals was characterized by early detection of its agent (starting from week 2 of immunosuppression), a progression of the infection and its transition to the generalized stage. The combined use of tricort-40 and infection of the animals with Leishmania infantum as an immunosuppressive cofactor ensured an increase in reproducibility of a manifest pneumocystosis model and its more rapid transition to the generalized stage. The experimental model of mixed infection of two AIDS-associated parasite infections--generalized pneumocystosis and visceral leishmaniasis--was first reproduced in inbred rats, which may be suitable for simultaneous screening of new antipneumocystic and antileishmanial drugs.
authors.forename: M V
authors.initials: MV
authors.lastname: Lavdovskaia
authors.forename: F P
authors.initials: FP
authors.lastname: Kovalenko
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Lysenko
authors.forename: M V
authors.initials: MV
authors.lastname: Strelkova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Chernov
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology; D018314:Leishmania infantum / Q000472:pathogenicity; D008297:Male; D011010:Pneumocystis / Q000472:pathogenicity; D016720:Pneumocystis Infections / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide
vernacular_title: Razrabotka novoĭ éksperimental'noĭ modeli pnevmotsistoza.