[The effect of obzidan on the duodenogastric dyskinesia induced by the ulcerogenic action of pentagastrin].
The effects of pentagastrin on gastroduodenal myoelectric activity were investigated in chronic experiments on rabbits before and after beta adrenoceptor blocking by propranolol. Ulcerogenic dose of pentagastrin (0.2 mg/kg) leads to bilateral duodenogastric dyskinesia, during which duodenal activity increased, and gastric one decreased. Propranolol (2 mg/kg) provoked a more significant pentagastrin-induced disfunction, retrograde duodenogastric dyskinesia. The results indicate a protective effect of the adrenergic mechanisms during pentagastrin ulcerogenesis.
Shemerovskiĭ
K A
KA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004347:Drug Interactions; D004386:Duodenum / Q000187:drug effects* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010418:Pentagastrin / Q000494:pharmacology*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000503:physiopathology*; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D013270:Stomach / Q000187:drug effects / Q000502:physiology
D011433:Propranolol; D010418:Pentagastrin
Vliianie obzidana na duodenogastral'nuiu diskineziiu, vyzvannuiu ul'tserogennym deĭstviem pentagastrina.