Potential new therapies for perinatal cerebral hypoxia-ischemia.
Recent studies in neonatal animals have shown that hypoxic-ischemic brain damage can be reduced by interventions initiated after the hypoxic-ischemic insult. In this article, the authors focus on potentially new modalities of therapy capable of preventing--or at least reducing--brain damage arising from perinatal cerebral hypoxia-ischemia. Management strategies include oxygen-free radical inhibitors and scavengers, excitatory amino acid antagonists, and calcium channel blocker. Additional information is provided regarding the critical role of glucose in perinatal cerebral hypoxia-ischemia and also the protective effect of hypothermia on preventing brain damage.
Palmer
C
C
Division of Neonatology, Pennsylvania State University School of Medicine, Milton S. Hershey Medical Center, Hershey.
Vannucci
R C
RC
D001238:Asphyxia Neonatorum / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers; D005947:Glucose / Q000502:physiology; D018698:Glutamic Acid; D006801:Humans; D007036:Hypothermia, Induced; D007231:Infant, Newborn; D011322:Primary Prevention
D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers; D018698:Glutamic Acid; D005947:Glucose