title: Ferric reductases or flavin reductases?
abstract: Assimilation of iron by microorganisms requires the presence of ferric reductases which participate in the mobilization of iron from ferrisiderophores. The common structural and catalytic properties of these enzymes are described and shown to be identical to those of flavin reductases. This strongly suggests that, in general, the reduction of iron depends on reduced flavins provided by flavin reductases.
authors.affiliation: Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Unité de Recherche Associée au CNRS 332, Université Joseph Fourier, Grenoble, France.
authors.forename: M
authors.initials: M
authors.lastname: Fontecave
authors.forename: J
authors.initials: J
authors.lastname: Covès
authors.forename: J L
authors.initials: JL
authors.lastname: Pierre
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D004579:Electron Transport; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D038181:FMN Reductase; D005798:Genes, Bacterial; D007501:Iron / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000502:physiology; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D017262:Siderophores / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D017262:Siderophores; D009249:NADP; D007501:Iron; D038181:FMN Reductase; D009247:NADH, NADPH Oxidoreductases; C023903:ferric citrate iron reductase