title: A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen.
abstract: BACKGROUND
  There have been conflicting data in literature about the value of Phyllanthus amarus in treating hepatitis B virus-related disorders.
  
  
  OBJECTIVE
  To evaluate the role of Phyllanthus amarus in eradication of the virus in hepatitis B carriers.
  
  
  METHODS
  Phyllanthus amarus was administered to 30 asymptomatic carriers of hepatitis B surface antigen (HBsAg) in a dosage of 250 to 500 mg thrice daily for 4 to 8 weeks.
  
  
  RESULTS
  None of the 30 subjects cleared HBsAg. Phyllanthus amarus was well tolerated, with no clinical side effects or changes in the organ profiles for safety evaluation.
  
  
  CONCLUSIONS
  Phyllanthus amarus is not effective in clearing HBsAg in asymptomatic carriers of the antigen.
authors.affiliation: Dr Balabhai Nanavati Hospital and Research Center, Juhu, Bombay.
authors.forename: J C
authors.initials: JC
authors.lastname: Doshi
authors.forename: A B
authors.initials: AB
authors.lastname: Vaidya
authors.forename: D S
authors.initials: DS
authors.lastname: Antarkar
authors.forename: R
authors.initials: R
authors.lastname: Deolalikar
authors.forename: D H
authors.initials: DH
authors.lastname: Antani
mesh_terms: D000328:Adult; D002353:Carrier State / Q000628:therapy*; D006509:Hepatitis B / Q000628:therapy*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007194:India; D008297:Male; D008519:Medicine, Traditional; D010946:Plants, Medicinal
chemical_list: D006514:Hepatitis B Surface Antigens