Vitamin E in tardive dyskinesia: time course of effect after placebo substitution.
Alpha-tocopherol (vitamin E) has been found to be effective in the treatment of tardive dyskinesia (TD). Studies to date have been short in duration and have not found long-term carryover effects of vitamin E. The present study examined the persistence of the effects of vitamin E after longer term (36-week) treatment was discontinued. Vitamin E significantly improved TD over this period. However, the effects of vitamin E persisted so that TD scores approached baseline only after 12 weeks of placebo substitution.
Adler
L A
LA
Psychiatry Service, New York Department of Veterans Affairs Medical Center (DVAMC), NY 10010.
Peselow
E
E
Duncan
E
E
Rosenthal
M
M
Angrist
B
B
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E