Agonistic activity and charge driven interaction potentiality of PAF derivatives.
Taking into account the contribution of the C2 substituent to the interaction ability of PAF derivatives, an investigation has been undertaken on: i) the role of the presence of two unitary charges of opposite sign in the molecule; ii) the role of the spacing of the same charged moieties. For this purpose, the theoretical analysis of model compounds for newly synthesized and already known compounds has been performed by means of computer-aided modelling, molecular mechanics and semiempirical quantum chemical computational methods. The combination of the results with the available pharmacological data allows a discussion about the stereoelectronic features required for agonist interaction at the PAF receptor.
Villa
L
L
Istituto di Chimica Farmaceutica e Tossicologia, Università di Milano.
Pallavicini
M
M
Villa
A M
AM
Valoti
E
E
Ferri
V
V
Berti
F
F
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008297:Male; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D010980:Platelet Membrane Glycoproteins / Q000187:drug effects; D011487:Protein Conformation; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D013237:Stereoisomerism; D014132:Trachea / Q000187:drug effects
D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor