[Immune status in patients with bone and joint tuberculosis and effect of HLA genotype].
The study included 41 patients (Uzbeks by nationality) with tuberculosis of the bones and joints. Of them 19 had localized tuberculosis and 22 disseminated process. The condition of T lymphocytes, B-lymphocytes and specific immunity were investigated by standard immunological methods. Typing by antigens HLA-DR was made with the help of standard microlymphocytotoxic test. It was established that patients with tuberculosis of the bones and joints have worse qualitative and quantitative characteristics of T lymphocytes, reduced number of B-lymphocytes, high specific response of lymphocytes to tuberculin compared to healthy subjects. Such patients have low B-cell level when they are free of antigen HLA-DR4. Carriers of HLA-DR2 antigen exhibit inhibited specific cellular immunity compared to those without this antigen.
Nazirov
P Kh
PKh
Ubaĭdullaev
A M
AM
Vakhidova
G A
GA
Pospelov
L E
LE
D001402:B-Lymphocytes / Q000276:immunology*; D005838:Genotype; D015802:HLA-DR2 Antigen / Q000276:immunology*; D015804:HLA-DR4 Antigen / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D014374:Tuberculin Test; D014394:Tuberculosis, Osteoarticular / Q000097:blood / Q000235:genetics / Q000276:immunology*
D015802:HLA-DR2 Antigen; D015804:HLA-DR4 Antigen
Immunnyĭ status bolńykh kostno-sustavnym tuberkulëzom i vliianie na nego genotipa HLA patsientov.