title: Persistent movement disorders induced by buspirone.
abstract: Buspirone, an azospirone compound, is a nonsedative anxiolytic that has achieved wide usage since its introduction in 1987. Although relatively free of side-effects, there have been several instances of dyskinesia and dystonia associated with the use of buspirone. We report two patients with persistent movement disorders that developed after prolonged treatment with the drug. One patient developed a lasting problem of cervical-cranial dystonia and tremors after treatment with buspirone at a dosage of 40 mg/day for several weeks. Another, receiving 30 mg/day for 6 weeks, experienced an exacerbation of preexisting spasmodic torticollis and tardive dyskinesia as well as the onset of involuntary phonations. As shown by these and other examples, buspirone poses the risk for inducing or exacerbating several types of movement disorders.
authors.affiliation: Clinical Neuroscience Program, Sinai Hospital, Detroit, Michigan.
authors.forename: P A
authors.initials: PA
authors.lastname: LeWitt
authors.forename: A
authors.initials: A
authors.lastname: Walters
authors.forename: W
authors.initials: W
authors.lastname: Hening
authors.forename: D
authors.initials: D
authors.lastname: McHale
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects; D002065:Buspirone / Q000009:adverse effects* / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D004421:Dystonia / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D010699:Phonation; D014103:Torticollis / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D002065:Buspirone