title: Evidence for GABAergic projections from the tegmental nuclei of Gudden to the mammillary body in the rat.
abstract: Immunochemical studies have demonstrated the presence of large numbers of cells immunoreactive for glutamic acid decarboxylase (GAD) within the dorsal and ventral tegmental nuclei of Gudden. Following injections of Fluoro-Gold into the medial mammillary nucleus, a substantial proportion of the retrogradely labeled neurons within the ventral tegmental nucleus displayed GAD-like immunoreactivity. Conversely, electrolytic or excitotoxic lesions of the ventral tegmental nucleus produced a large decrease in the number of fibers and terminals immunoreactive for GAD within the medial mammillary nucleus. In contrast, electrolytic lesions of the dorsal tegmental nucleus were found to produce a large decrease in GAD-like immunoreactivity which was restricted to the lateral mammillary nucleus. Control lesions placed caudal to the dorsal tegmental nucleus were without effect. These findings suggest that the dorsal and ventral nuclei send a substantial, topographically organized, GABAeregic input to the mammillary body.
authors.affiliation: Department of Psychology, University of Illinois at Chicago 60680.
authors.forename: D
authors.initials: D
authors.lastname: Wirtshafter
authors.forename: T R
authors.initials: TR
authors.lastname: Stratford
mesh_terms: D000818:Animals; D005455:Fluorescent Antibody Technique; D008297:Male; D008326:Mammillary Bodies / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013681:Tegmentum Mesencephali / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid