title: [Serum levels of vitamin B12 in epileptic patients treated with carbamazepine].
abstract: In 21 epileptic patients (11 females and 10 males) aged 18-55 years on carbamazepine (CBZ) therapy the serum levels of vitamin B12 were measured. Mean serum level of vitamin B12 in epileptic patients was in the same range as compared to the values in healthy subjects. However, there were differences depending on the drug dose, treatment duration and course of epilepsy. The mean serum level of vitamin B12 was lower in epileptic patients with earlier age of disease onset, frequent seizures and with higher drug dose (above 600 mg/d). In patients treated longer than 15 years the vitamin B12 serum level amounted to 65 per cent of the values in control group.
authors.affiliation: II Katedry i Kliniki Neurologii Sl. Akademii Medycznej w Zabrzu.
authors.forename: D
authors.initials: D
authors.lastname: Rościszewska
authors.forename: E
authors.initials: E
authors.lastname: Motta
authors.forename: I
authors.initials: I
authors.lastname: Guz
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014805:Vitamin B 12 / Q000097:blood*
chemical_list: D002220:Carbamazepine; D014805:Vitamin B 12
vernacular_title: Poziom witaminy B12 u chorych na padaczke leczonych karbamazepina.