Platelet-activating factor inhibits excitatory transmission in rat neostriatum.
Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.
Jiang
Z G
ZG
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201-3098.
Yue
T L
TL
Feuerstein
G
G
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D017072:Neostriatum / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010980:Platelet Membrane Glycoproteins; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D043562:Receptors, G-Protein-Coupled; D014230:Triazoles / Q000494:pharmacology
D001381:Azepines; D005971:Glutamates; C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011810:Quinoxalines; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D014230:Triazoles; C039351:platelet activating factor receptor; C064509:BN 50739; D018698:Glutamic Acid; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D015763:2-Amino-5-phosphonovalerate