[The adrenergic regulation of interleukin production by bone marrow cells during immobilization stress].
Adrenergic regulation of interleukin-1 (IL-1) and interleukin-3 (IL-3) activities production by adhesive and nonadhesive bone marrow cells under immobilization stress has been studied in experiments on F1 (CBA x C57Bl/6) mice. 10-hour immobilization had been established to lead to rise of IL-1 and IL-3 activities in supernatants on days 2, 5 and 1, 2, 4, 5, 7 after stress, respectively. The use of Wilcoxon rank T-test demonstrated that alpha-adrenergic antagonist (dihydroergotaminum, 3.9 mg/kg) injection to stressed mice suppressed exclusively IL-1 activities production. At the same time, beta-adrenoblocker (propranolol, 5 mg/kg) inhibited IL-3 production. Thus, adrenergic structures take an active part in regulation of IL-1 and IL-3 production by haemopoiesis inducing microenvironment bone marrow cells under immobilization stress.
Khlusov
I A
IA
Dygaĭ
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000503:physiopathology*; D001854:Bone Marrow Cells; D004087:Dihydroergotamine / Q000494:pharmacology; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis*; D007377:Interleukin-3 / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
D007375:Interleukin-1; D007377:Interleukin-3; D011941:Receptors, Adrenergic; D004087:Dihydroergotamine; D011433:Propranolol
Adrenergicheskaia reguliatsiia produktsii interleĭkinov kletkami kostnogo mozga v usloviiakh immobilizatsionnogo stressa.