Insulin-like growth factor-I comparisons in healthy twin children.
Insulin-like growth factor-I (IGF-I) levels in plasma were measured in healthy twin children. The within-pair correlation for 43 monozygotic pairs was r = 0.91 (P < or = 0.0001), an association significantly higher than that for same sex dizygotic pairs (r = 0.40; P < or = 0.06). The high correlation for monozygotic twins indicated a marked genetic influence on IGF-I levels. After correction for age and sex, the correlation between IGF-I level and height was r = 0.38 (P < or = 0.0001). These findings provide clear evidence that IGF-I levels correlate with height, a growth characteristic known to be genetically controlled.
Kao
P C
PC
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Matheny
A P
AP
Lang
C A
CA
D000375:Aging / Q000097:blood / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D001827:Body Height / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D008297:Male; D010641:Phenotype; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D015415:Biomarkers; D007334:Insulin-Like Growth Factor I