Lack of association between bipolar affective disorder and tyrosine hydroxylase DNA marker.
Sixty-eight patients with bipolar affective disorder and 88 controls were investigated for genetic association of tyrosine hydroxylase (TH) restriction fragment length polymorphisms (RFLPs). No significant association between bipolar affective disorder and TH was found. Thus the hypothesis that TH is involved in the pathogenesis of bipolar affective disorder was not supported.
Inayama
Y
Y
Department of Neuropsychiatry, Osaka Medical College, Japan.
Yoneda
H
H
Sakai
T
T
Ishida
T
T
Kobayashi
S
S
Nonomura
Y
Y
Kono
Y
Y
Koh
J
J
Asaba
H
H
D000328:Adult; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D005819:Genetic Markers; D014446:Tyrosine 3-Monooxygenase