Proton nuclear magnetic resonance analysis of liver metabolites from mice infected with Mesocestoides vogae.
Proton NMR spectra of liver extracts from mice infected with Mesocestoides vogae for 24 or 133 days showed differences in the concentrations of liver metabolites when compared to those of normal liver. Moderately infected livers (24 d.p.i.) had significantly less glucose and significantly more glycine, cholines, alanine and lactate than uninfected controls. Similar changes in the concentrations of these metabolites were also found in mice with heavily infected livers (133 d.p.i.), and, in addition, there was significantly more succinate in this group than in the other 2 groups. Furthermore, the heavily infected livers contained more taurine and less acetate than the controls. Tetrathyridia extracts were rich in glycogen and contained high levels of betaine.
Blackburn
B J
BJ
Department of Chemistry, University of Winnipeg, Manitoba, Canada.
Hudspeth
C
C
Novak
M
M
D000818:Animals; D002590:Cestode Infections / Q000378:metabolism*; D005500:Follow-Up Studies; D006790:Host-Parasite Interactions; D008099:Liver / Q000378:metabolism* / Q000469:parasitology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008645:Mesocestoides / Q000502:physiology*; D051379:Mice