Reversibility of the differentiated state in somatic cells.
Analysis of de novo gene activation in multinucleated heterokaryons has shown that the differentiated state, although stable, is not irreversible, and can be reprogrammed in the presence of appropriate combinations of trans-acting regulatory molecules. These properties have been exploited to design strategies for identifying novel regulators of cellular differentiation.
Baron
M H
MH
Harvard University, Cambridge.
D000818:Animals; D002454:Cell Differentiation; D002459:Cell Fusion; D004268:DNA-Binding Proteins / Q000502:physiology; D015672:Erythroid Precursor Cells / Q000166:cytology; D050981:Erythroid-Specific DNA-Binding Factors; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D051379:Mice; D009132:Muscles / Q000166:cytology; D009928:Organ Specificity; D013234:Stem Cells / Q000166:cytology; D014157:Transcription Factors / Q000502:physiology; D015533:Transcriptional Activation
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D006133:Growth Substances; D014157:Transcription Factors