title: Species barrier prevents an abnormal isoform of prion protein from accumulating in follicular dendritic cells of mice with Creutzfeldt-Jakob disease.
abstract: The accumulation of abnormal prion protein in follicular dendritic cells did not occur in mice inoculated with materials from human Creutzfeldt-Jakob disease, whereas it always occurred in mice inoculated with mouse-adapted agents, suggesting an intense expression of the species barrier in the lymphoreticular system.
authors.affiliation: Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Muramoto
authors.forename: T
authors.initials: T
authors.lastname: Kitamoto
authors.forename: M Z
authors.initials: MZ
authors.lastname: Hoque
authors.forename: J
authors.initials: J
authors.lastname: Tateishi
authors.forename: I
authors.initials: I
authors.lastname: Goto
mesh_terms: D000368:Aged; D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism*; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D008221:Lymphoid Tissue / Q000378:metabolism; D008297:Male; D051379:Mice; D008875:Middle Aged; D018620:PrPSc Proteins; D011328:Prions / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D018620:PrPSc Proteins; D011328:Prions