[Mutagenic effect of pindone on D. melanogaster].
A commercial grade Pindone was tested for the induction of genetic damage in male germ cells of Drosophila melanogaster by adult ingestion. Adults were starved for 4 days and then fed pindone at a concentration of 1 mM in ethyl alcohol 15% containing sucrose 5%. Pindone was found to increase the frequency of sex chromosome loss. Results were significant at the 1% level (Kastenbaum-Bowman test). However no significant results were obtained by the sex linked recessive lethal assay.
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Dipartimento di Zoologia, Università degli Studi di Napoli.
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D000818:Animals; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D005260:Female; D017344:Genes, Insect / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D007189:Indans / Q000633:toxicity*; D008297:Male; D009152:Mutagenicity Tests; D009630:Nondisjunction, Genetic; D012378:Rodenticides / Q000633:toxicity*; D012730:Sex Chromosomes
D007189:Indans; D012378:Rodenticides; C014152:pindone
Effetti mutagenetici del pindone su D. melanogaster.