Fibrils from synthetic amyloid-related peptides enhance development of experimental AA-amyloidosis in mice.
Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small fibrils serving as nucleation centers for fibril elongation.
Ganowiak
K
K
Department of Pathology, University Hospital, Linköping, Sweden.
Hultman
P
P
Engström
U
U
Gustavsson
A
A
Westermark
P
P
D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry* / Q000494:pharmacology; D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D000818:Animals; D005260:Female; D006023:Glycoproteins; D058228:Islet Amyloid Polypeptide; D051379:Mice; D008969:Molecular Sequence Data; D011228:Prealbumin / Q000737:chemistry* / Q000494:pharmacology; D012835:Silver Nitrate / Q000494:pharmacology; D013154:Spleen / Q000473:pathology; D013997:Time Factors
D000682:Amyloid; D006023:Glycoproteins; D058228:Islet Amyloid Polypeptide; D011228:Prealbumin; C046748:amyloid enhancing factor; D012835:Silver Nitrate