title: Lateral migration of blood cells and microspheres in two-dimensional Poiseuille flow: a laser-Doppler study.
abstract: The inertia-induced lateral migration of rigid microspheres, platelets and erythrocytes is studied experimentally. The concentration and velocity profiles of the particles have been determined with a laser-Doppler anemometer designed for high resolution measurements. Data are compared with empirical and analytical models on inertia-induced lateral migration of rigid spheres. Experiments done in rectangular flow channels of high aspect ratio reveal that at a sufficiently high particle Reynolds number, platelets exhibit tubular pinch effects comparable with those of rigid polystyrene microspheres. Erythrocytes also exhibit inertia-induced lateral migration at high particle Reynolds number and low medium viscosity. At a higher medium viscosity, erythrocytes show deformation-induced lateral migration towards the center of the flow channel.
authors.affiliation: Department of Medical and Physiological Physics, University of Utrecht, The Netherlands.
authors.forename: W S
authors.initials: WS
authors.lastname: Uijttewaal
authors.forename: E J
authors.initials: EJ
authors.lastname: Nijhof
authors.forename: R M
authors.initials: RM
authors.lastname: Heethaar
mesh_terms: D001783:Blood Flow Velocity; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D002465:Cell Movement; D048429:Cell Size; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology*; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation; D008863:Microspheres; D008954:Models, Biological; D010316:Particle Size; D011137:Polystyrenes; D011673:Pulsatile Flow; D012212:Rheology; D012399:Rotation; D014783:Viscosity
chemical_list: D011137:Polystyrenes