[The status of various indicators of the protease inhibitor system in blood and synovial fluid in rheumatoid arthritis].
Elastase-like activity, alpha 1-inhibitor of proteinases and acid stable antitryptic activity were studied in blood of 26 patients and in synovial fluid of 11 patients with rheumatoid arthritis during acute stage of the disease and after treatment with salase pyridasine and orthophene. The higher values of the elastase-like activity were detected in synovial fluid as compared with that of blood. In blood of these patients, hyperproduction of alpha 1-inhibitor of proteinases and acid stable inhibitors was observed, while deficiency of these substances occurred in synovial fluid. Distinct decrease in the patterns of the blood protease-inhibitory system studied simultaneously with clear positive clinical effect were observed after treatment with salase pyridasine together with orthophene; estimation of these patterns may be used in the evaluation of the therapy.
Danilova
T G
TG
Platonova
L V
LV
Paskhina
T S
TS
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D004008:Diclofenac / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000097:blood*; D012460:Sulfasalazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013582:Synovial Fluid / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011480:Protease Inhibitors; D004008:Diclofenac; C009943:salazodin; D012460:Sulfasalazine
Sostoianie nekotorykh pokazateleĭ proteazno-ingibitornoĭ sistemy krovi i sinovial'noĭ zhidkosti pri revmatoidnom artrite.