Potential antitumor agents. XXII. Synthesis and cytotoxic activity of imidazo [2,1-b]thiazole adamantylthioureas.
A series of imidazo[2,1-b]thiazole adamantylthioureas (3a-f) was synthesized by reaction of the methylsulfanylethylamines 2a-f (prepared in turn from the hydroxymethylimidazo[2,1-b]thiazoles 1a-f and cysteamine) with 1-adamantylisothiocyanate. 1-Adamant-1-yl-3-[2-(6-chloro-2,3- dihydroimidazo[2,1-b]thiazol-5-ylmethylsulfanyl)ethyl] thiourea (3d) was significantly active.
Andreani
A
A
Università di Bologna, Dipartimento di Scienze Farmaceutiche, Via Belmeloro 6, Italy.
Rambaldi
M
M
Locatelli
A
A
Bossa
R
R
Fraccari
A
A
Galatulas
I
I
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013844:Thiazoles; C086101:1-(adamant-1-yl)-3-(2-(6-chloro-2,3-dihydroimidazo(2,1-b)thiazol-5-ylmethylsulfonyl)ethyl)thiourea; D013890:Thiourea