title: Age-related changes in auditory evoked potentials of gerbils. II. Response latencies.
abstract: Auditory brainstem responses (ABR) were recorded in young (6-10 month) and aged (36 month) Mongolian gerbils. Data from the young animals served as the baselines for comparison to aged animals which were categorized on the basis of ABR thresholds. Aged gerbils with normal thresholds (re young controls) had wave i and ii latencies of the ABR which were relatively normal at 1-4 kHz and slightly reduced at 8 and 16 kHz. Wave iv latencies in the aged gerbils with normal thresholds were reduced at all frequencies. Aged gerbils with 10-30 dB of hearing loss had wave i, ii, and iv latencies which were prolonged at low sound pressure levels and normal at high stimulus levels. Aged gerbils with 30 dB or greater losses had prolonged wave i, ii, and iv latencies at most levels. Slopes of latency-intensity (L/I) functions were steeper at 1-4 kHz than controls in aged subjects with hearing losses of 10 dB or greater. Slopes of L/I functions for wave iv were normal in aged subjects. The wave i-iv interval was shorter than normal in aged subjects with no hearing loss, normal in aged subjects with 10-30 dB of loss, and prolonged in subjects with greater than 30 dB of loss.
authors.affiliation: Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston 29425-2242.
authors.forename: F A
authors.initials: FA
authors.lastname: Boettcher
authors.forename: J H
authors.initials: JH
authors.lastname: Mills
authors.forename: B L
authors.initials: BL
authors.lastname: Norton
authors.forename: R A
authors.initials: RA
authors.lastname: Schmiedt
mesh_terms: D000161:Acoustic Stimulation; D000375:Aging / Q000502:physiology*; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005849:Gerbillinae / Q000502:physiology; D016011:Normal Distribution; D011930:Reaction Time