Human insulin-like growth factor type I and type II receptors are not imprinted.
We have shown that the insulin-like growth factor type I and II receptors are expressed equally from the maternal and paternal alleles in human tissues. The imprinting status of the type I insulin-like growth factor receptor has not been reported while the type II receptor has previously been shown to be maternally expressed in the mouse. That the imprinting of the insulin-like growth factor type II receptor is not conserved between mouse and humans suggests that the physiological role of the IGF2 receptor may differ between these two species.
Ogawa
O
O
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
McNoe
L A
LA
Eccles
M R
MR
Morison
I M
IM
Reeve
A E
AE
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D005333:Fetus; D006801:Humans; D007668:Kidney / Q000196:embryology / Q000378:metabolism; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011247:Pregnancy; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis / Q000235:genetics*; D017527:Receptor, IGF Type 2 / Q000096:biosynthesis / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
D017931:DNA Primers; D017527:Receptor, IGF Type 2; D017526:Receptor, IGF Type 1