Some new quinoline-based mono and dicarboxylic acids.
Some quinoline-based mono- and dicarboxylic acids structurally related to kynurenic acid have been synthesized and screened as antagonists of neurotransmission of NMDA, AMPA and KA excitatory amino acid receptors. Higher affinity for NMDA receptor was pointed out in the short series, but all the compounds, even those with key structural features of glutamic acid showed no significant activity.
Ferranti
A
A
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
Garuti
L
L
Giovanninetti
G
G
Roberti
M
M
Varoli
L
L
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D003998:Dicarboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D017459:Receptors, Amino Acid / Q000037:antagonists & inhibitors*; D018092:Kainic Acid Receptors / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D009435:Synaptic Transmission / Q000187:drug effects
D002264:Carboxylic Acids; D003998:Dicarboxylic Acids; D011804:Quinolines; D018091:Receptors, AMPA; D017459:Receptors, Amino Acid; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate