Graphical representations of the class I MHC cleft.
We describe computer graphics and computer aided manufacture of three-dimensional models designed specifically to elucidate the cleft in the class I human leukocyte antigen. The models evolve from computer graphical representations and provide a geometrically and chemically concise and detailed view of the antigen binding site. The techniques provide a new approach to representations of binding sites. The model provides sufficient detail to support binding specificities analysis of active sites involved in protein and DNA binding.
Cornette
J L
JL
Department of Mathematics, Iowa State University, Ames 50011.
King
B L
BL
Silverman
M D
MD
DeLisi
C
C
D001665:Binding Sites; D003196:Computer Graphics; D004563:Electrochemistry; D015234:HLA-A Antigens / Q000737:chemistry*; D015789:HLA-A2 Antigen / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation
D015234:HLA-A Antigens; C053029:HLA-A*68 antigen; D015789:HLA-A2 Antigen