title: N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) excretion after acute administration of acetaminophen, salsalate and aspirin in rats.
abstract: The present study was performed to compare renal injury induced by high acute doses of both the nonacetylated salicylate, salsalate (SSA) and the acetylated salicylate, aspirin (ASA). As a marker of renal injury, urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) were measured after oral administration of 600 mg/kg of each drug. Other tests to detect renal injury were also performed. Serum salicylic levels after SSA or ASA were determined in a different experiment. Acetaminophen (APAP) was used as a standard of renal toxicity. Both drugs increase NAG and to a greater extent, AAP excretion. Proteinuria and polyuria appear after both drugs. Changes in urinary sodium and potassium were also shown. Our results support the view that both acetylated and non-acetylated salicylates induce renal injury at toxicological doses.
authors.affiliation: Department of Physiological Sciences, School of Pharmacy, Barcelona University, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Casadevall
authors.forename: J J
authors.initials: JJ
authors.lastname: Moreno
authors.forename: M A
authors.initials: MA
authors.lastname: Franch
authors.forename: J
authors.initials: J
authors.lastname: Queralt
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000633:toxicity*; D000118:Acetylglucosaminidase / Q000652:urine*; D000284:Administration, Oral; D000626:Aminopeptidases / Q000652:urine*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000633:toxicity*; D018826:CD13 Antigens; D004231:Diuresis / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012459:Salicylates / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D020156:Salicylic Acid; D012964:Sodium / Q000652:urine; D013054:Spectrophotometry, Atomic
chemical_list: D012459:Salicylates; D000082:Acetaminophen; D012964:Sodium; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens; D020156:Salicylic Acid; D001241:Aspirin; D011188:Potassium; C014182:salicylsalicylic acid