title: The fractional volume available to prolate spheroids in a network of randomly oriented fibers obtained by computer modeling: correlation with the Ogston equation.
abstract: Computer modeling was used to measure the fractional volumes available to prolate spheroid objects in a random, inert network of fibers. The data fit the Ogston equation exactly when the object was a sphere (axial ratio = 1). When the axial ratio was increased from 1 to 9, the Ogston equation was still obeyed if the fiber concentration is multiplied by a factor, A, which increases linearly in proportion to the axial ratio. The factor A allows one to adjust the retardation coefficient derived from gel electrophoresis, KR, for spherical objects to that of prolate spheroids with axial ratios from 1 to 9. Potentially, the same adjustment of KR is possible for objects of other shapes.
authors.affiliation: Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
authors.forename: D
authors.initials: D
authors.lastname: Wheeler
authors.forename: A
authors.initials: A
authors.lastname: Chrambach
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D008433:Mathematics; D008962:Models, Theoretical; D011897:Random Allocation; D012984:Software