title: [Molluscacidal activity of spiro-alpha-methylene-gamma-butyrolactone].
abstract: The alpha-methylene-gamma-butyrolactones 1-28 were tested in vitro for molluscicidal activity against Biomphalaria glabrata. The racemic compound 25 shows the best activity. The synthesis was carried out by modified Reformatzky reaction of the corresponding carbonyl compounds and bromomethylacrylic acid ethyl ester. 7-10, 17 and 22-27 have been synthesized for the first time.
authors.affiliation: Pharmazeutisches Institut, Rheinischen Friedrich-Wilhelms-Universität Bonn.
authors.forename: G
authors.initials: G
authors.lastname: Rücker
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
authors.forename: W
authors.initials: W
authors.lastname: Gajewski
authors.forename: M
authors.initials: M
authors.lastname: Löbbert
authors.forename: P
authors.initials: P
authors.lastname: Böken
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001700:Biomphalaria / Q000502:physiology*; D008975:Molluscacides / Q000138:chemical synthesis* / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D008975:Molluscacides; D013141:Spiro Compounds; D015107:4-Butyrolactone
vernacular_title: Molluskizid wirksame Spiro-alpha-methylen-gamma-butyrolactone.