Oxygen free radicals and acute pancreatitis: fact or fiction?
The effect of oxygen free radical suppression was studied in the taurocholate model of acute pancreatitis in the rat using systemic allopurinol, superoxide dismutase (S.O.D.) and catalase. None of the treatments were beneficial which suggests that oxygen free radical suppression is unlikely to be clinically beneficial in acute pancreatitis.
Creagh
T A
TA
Department of Surgery, Beaumont Hospital, Dublin, Ireland.
Leahy
A L
AL
Bouchier-Hayes
D J
DJ
Tormey
W
W
Leader
M
M
Broe
P J
PJ
D000208:Acute Disease; D000818:Animals; D005609:Free Radicals; D008297:Male; D010100:Oxygen / Q000737:chemistry*; D010195:Pancreatitis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005609:Free Radicals; D010100:Oxygen