title: An appraisal of techniques for administration of gaseous nitric oxide.
abstract: Gaseous nitric oxide (NO) is a potent selective pulmonary vasodilator. When mixed with O2 for more than 10-15 minutes it forms toxic amounts of nitrogen dioxide (NO2). We describe two techniques to administer 20 parts per million (ppm) during mechanical ventilation. A technique using flows of NO and O2 at low pressure to drive a Siemens Servo 900C ventilator provided a constant inspired concentration of NO. Another technique in which NO was added to the inspiratory limb of a Siemens Servo 900C ventilator driven by high pressure oxygen provided a highly variable concentration (9-53 ppm) of inspired NO.
authors.affiliation: Intensive Care Unit, Royal Children's Hospital, Melbourne, Victoria.
authors.forename: J
authors.initials: J
authors.lastname: Tibballs
authors.forename: M
authors.initials: M
authors.lastname: Hochmann
authors.forename: B
authors.initials: B
authors.lastname: Carter
authors.forename: A
authors.initials: A
authors.lastname: Osborne
mesh_terms: D000769:Anesthesia, Inhalation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D015920:Gas Scavengers; D006801:Humans; D001239:Inhalation; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage* / Q000032:analysis; D011312:Pressure; D012212:Rheology / Q000295:instrumentation; D012122:Ventilators, Mechanical
chemical_list: D009569:Nitric Oxide; D010100:Oxygen