[The effect of a diet enriched with polyunsaturated fatty acids on the state of the Ca-transport system in the myocardial sarcoplasmic reticulum].
It was studied the influence of diet enriched with PUFA on the level of lipid peroxidation (LP) and rate of Ca-transport of sarcoplasmic reticulum (SR) of heart. The initial myocardial level of products of LP after the diet enriched with PUFA was two times higher than in control and this was associated with uneffected rate of Ca-transport. When kinetic analysis of myocardial Ca-transport with different concentration of Ca and process of autolysis were effectuated we could'nt show qualitative changes of state of Ca-transport system during diet with PUFA. For estimation of this effects comparison of two process were carried out--the increase of LP products and inhibition of Ca-transport of SR during LP induction in vitro. We shown, that after died enriched with PUFA identical level of LP products was accompanied with 3.5 times higher rate of inhibition of Ca-transport. As a result, we can say, that diet enriched with PUFA lead to considerable increase of resistance of Ca-transport system for LP induction and for high level of its oxidative products. The repeated compensated activation of LP was connected with adaptive effect, which could support the basic level of rate of Ca-transport. The mechanisms of these effect were discussed and comparison with adaptation for hypoxia was carried out.
Sazontova
T G
TG
Fu
S Ts
STs
Belkina
L M
LM
Arkhipenko
Iu V
IuV
Meerson
F Z
FZ
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000378:metabolism / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism
D004042:Dietary Fats, Unsaturated; D005609:Free Radicals; D002118:Calcium
Vliianie diety, obogashchennoĭ polinenasyshchennymi zhirnymi kislotami, na sostoianie Ca-transportiruiushcheĭ sistemy sarkoplazmaticheskogo retikuluma miokarda.