Precise localization on chromosome 12 of the ATF-1 gene by fluorescence in situ hybridization.
The ATF-1 gene encodes for a transcription factor normally regulated by cAMP (Hai et al. 1989, Yoshimura et al. 1990). Recently, it has been shown to be involved in the recurrent t(12;22) translocation observed in soft tissue malignant melanoma, in a fusion gene with the EWS gene (Zucman et al. 1993). We report here on its precise localization on chromosome 12 by fluorescence in situ hybridization.
Desmaze
C
C
Laboratoire de Génétique des Tumeurs, INSERM CJF 9201, Institut Curie, Paris, France.
Zucman
J
J
Delattre
O
O
Melot
T
T
Thomas
G
G
Aurias
A
A
D051697:Activating Transcription Factor 1; D002881:Chromosomes, Human, Pair 12 / Q000737:chemistry*; D004268:DNA-Binding Proteins; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D014157:Transcription Factors / Q000235:genetics*
D051697:Activating Transcription Factor 1; D004268:DNA-Binding Proteins; D014157:Transcription Factors