title: Computer assisted CT-guided stereotactic transplantation of foetal ventral mesencephalon to the caudate nucleus and putamen in Parkinson's disease.
abstract: We report our preliminary results related to CT-guided stereotactic transplantation of foetal ventral mesencephalic cell suspension into the striatum of five patients with idiopathic Parkinson's disease. The mean age was 51 years, the evolution time of the disease ranged from 7 to 14 years, and all of them had motor complications associated with chronic L-dopa therapy. The patients were evaluated according to the Core Assessment Program for Intracerebral Transplantations (CAPIT) for one year before and three months after surgery. The postoperative clinical assessment demonstrated significant improvement of neurological symptoms and reduction of daily L-dopa dosage.
authors.affiliation: Centro Iberolatinoamericano de Trasplante y Regeneración del Sistema Nervioso, Ciudad de la Habana, Cuba.
authors.forename: H
authors.initials: H
authors.lastname: Molina
authors.forename: R
authors.initials: R
authors.lastname: Quiñones
authors.forename: I
authors.initials: I
authors.lastname: Ortega
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
authors.forename: J
authors.initials: J
authors.lastname: Muñoz
authors.forename: C
authors.initials: C
authors.lastname: Gonzalez
authors.forename: C
authors.initials: C
authors.lastname: Suárez
mesh_terms: D002421:Caudate Nucleus / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods*; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation*; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000601:surgery*; D011699:Putamen / Q000601:surgery*; D013238:Stereotaxic Techniques; D013813:Therapy, Computer-Assisted; D014057:Tomography, X-Ray Computed
chemical_list: D007980:Levodopa