Effects of concurrent administration of lead and selenium on some haematological and biochemical parameters of broiler chickens.
As compared to intoxication with lead or selenium alone, the concurrent administration of lead and selenium to broiler chickens produced more deleterious effects characterized by adverse changes in haematological parameters and severe alterations in serum total protein, aspartate aminotransferase (AST), cholesterol and alkaline phosphatase levels. Deleterious effects were more pronounced when lead was administered as second toxic chemical in the presence of selenium in the diet of the birds. Significant haematological depressions leading to anaemia were recorded during subacute lead toxicosis when selenium was concurrently administered in the feed, indicating an enhancement of lead toxicity in the presence of selenium.
Khan
M Z
MZ
University of Agriculture and Technology, Department of Forensic Veterinary Medicine, Olsztyn, Poland.
Szarek
J
J
Krasnodebska-Depta
A
A
Koncicki
A
A
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis; D002645:Chickens / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004357:Drug Synergism; D004798:Enzymes / Q000097:blood; D007854:Lead / Q000633:toxicity*; D012643:Selenium / Q000633:toxicity*
D001798:Blood Proteins; D004798:Enzymes; D007854:Lead; D002784:Cholesterol; D012643:Selenium