Sequence of a cDNA encoding the p53 protein in rhesus monkey (Macaca mulatta).
A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.
Kay
H D
HD
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-6840.
Mountjoy
C P
CP
Wu
G
G
Cornish
K G
KG
Smith
L J
LJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D017931:DNA Primers; D018076:DNA, Complementary / Q000737:chemistry; D005091:Exons; D016158:Genes, p53; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics*
D017931:DNA Primers; D018076:DNA, Complementary; D016159:Tumor Suppressor Protein p53