[Portal-transfer of an orally administered anti-cancer agent analysis of the time course of portal blood and systemic blood levels of preoperatively administered UFT].
The transfer of an orally administered anti-cancer agent, UFT, into the portal vein was examined in 21 patients with hepatic metastasis of colorectal cancer (synchronous metastasis in 9 and metachronous metastasis in 12 cases) encountered at our department. The time course of tegafur, 5-FU and uracil levels in portal blood was traced for maximum 6 hrs, starting 2 hrs after the final oral dose of UFT. The portal blood tegafur level was 11.89 +/- 4.31 micrograms/ml at 2 hrs after the final dose and decreased gradually thereafter, reaching to 8.48 +/- 8.42 micrograms/ml at 6 hrs after the final dose. Unlike the portal blood tegafur level, the portal blood 5-FU level did not show any similar tendency; it remained almost unchanged at 0.018 +/- 0.006 microgram/ml and approximately equal to the serum 5-FU level throughout the observation period.
Yoshikawa
K
K
Dept. of Surgery, Osaka Rosai Hospital.
Hashimoto
T
T
Yamaguchi
T
T
Dousei
T
T
Moriguchi
S
S
Taniguchi
M
M
Ueda
H
H
Taketani
S
S
Utsumi
T
T
Suhara
H
H
D000284:Administration, Oral; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015179:Colorectal Neoplasms / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000378:metabolism*; D005641:Tegafur / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D014498:Uracil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
D005641:Tegafur; D014498:Uracil