Rapid measurement of urinary IL-6 by ELISA: urinary IL-6 as a marker of mesangial proliferation.
To determine whether the urinary level of interleukin 6 (IL-6) measured by enzyme-linked immunosorbent assay (ELISA) can be used as a marker of mesangial proliferation, we studied urinary levels of IL-6 in 124 patients with primary and secondary glomerulonephritis, using ELISA. Although urinary levels of IL-6 were correlated with the degree of mesangial proliferation, there was no correlation between urinary levels of IL-6 and urinary protein excretion or renal function. Urinary levels of low-molecular-weight proteins, which are parameters of tubular dysfunction, were not correlated with the urinary excretion of IL-6. These results suggest that the urinary level of IL-6 may be a useful marker for mesangial proliferation.
Hirata
E
E
First Department of Internal Medicine, Nara Medical University, Japan.
Iwano
M
M
Hirayama
T
T
Horii
Y
Y
Kitamura
Y
Y
Kishimoto
T
T
Hanatani
M
M
Dohi
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D002455:Cell Division; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology*; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D015850:Interleukin-6 / Q000652:urine*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D015850:Interleukin-6