title: Negative-type electroretinogram from cisplatin toxicity.
abstract: A 68-year-old woman with ovarian cancer suffered a loss of visual acuity and color perception after inadvertent overdosage with the antineoplastic agent cisplatin. Her acuity returned to normal but a tritan color defect persisted more than a year later. Her electroretinogram was stable between 7 weeks and 15 months after cisplatin administration, with a negative-type scotopic response, but also reduced cone b waves and a loss of some scotopic oscillatory potentials. With light stimuli between 10 and 100 ms in duration, the photopic on-responses were markedly reduced while the off-responses were normal or close to it. This case suggests that cisplatin may selectively injure on-pathways in the retina and indicates the need to expand the list of disorders that may cause a negative-type electroretinogram.
authors.affiliation: Department of Ophthalmology, Stanford University School of Medicine, California.
authors.forename: M F
authors.initials: MF
authors.lastname: Marmor
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000506:poisoning* / Q000627:therapeutic use; D003117:Color Vision Defects / Q000139:chemically induced / Q000503:physiopathology; D062787:Drug Overdose; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012160:Retina / Q000187:drug effects* / Q000502:physiology; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D002945:Cisplatin