Angiotensin converting enzyme in renal ontogeny: hypothesis for multiple roles.
Angiotensin converting enzyme (ACE) has multiple effects both as the enzyme which cleaves angiotensin II from angiotensin I and as that which breaks down bradykinin. The present study examines ACE mRNA and protein expression in the rat kidney during development. Changes in distribution and expression during development are consistent with suggestions that the renin angiotensin system is important in growth modulation, vascular development and regulation, and protein reabsorption.
Jung
F F
FF
Pediatric Renal Research Laboratory, Massachusetts General Hospital, Boston, 02114.
Bouyounes
B
B
Barrio
R
R
Tang
S S
SS
Diamant
D
D
Ingelfinger
J R
JR
D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007668:Kidney / Q000196:embryology* / Q000201:enzymology*; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000096:biosynthesis; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology
D012333:RNA, Messenger; D007703:Peptidyl-Dipeptidase A; D012083:Renin