title: [The incidence of second neoplasms in advanced laryngeal cancer. Impact on survival].
abstract: BACKGROUND
  The incidence of second neoplasms in laryngeal cancer is greater than that of other neoplasms. The appearance of a second neoplasm in these patients represents an important decrease in survival. The prevalence of second neoplasms in laryngeal cancer and its impact on survival was determined in this study.
  
  
  METHODS
  Seventy-eight patients with advanced laryngeal cancer (stages III and IV of the UICC) who had been treated with erradicative surgery from January 1984 to December 1988; and who were attended in the Radiotherapy and Oncology Department of the Ciutat Sanitària i Universitària Vall d'Hebron were retrospectively studied. All were postoperatively submitted to radiotherapy.
  
  
  RESULTS
  Ten of the 78 patients studied (13%) developed a second neoplasm. The most frequent localization was pulmonary (70%). In 9 of the 10 patients the appearance of the second neoplasm was considered metachronic with 60% being detected within the first 24 months after the diagnosis of the laryngeal neoplasm. The survival of the whole group was 80% at 2 years and 51% at 5 years. Survival of the patients with the second neoplasm was lower: 71% at 2 years and 5% at 5 years (p < 0.0001).
  
  
  CONCLUSIONS
  The presence of a second neoplasm in patients with laryngeal cancer is high. The survival of patients with advanced laryngeal cancer who develop a second neoplasm is significantly lower than that of other patients with this neoplasm.
authors.affiliation: Servicios de Radioterapia y Oncología y Hematología Clínica, Universidad Autónoma de Barcelona.
authors.forename: A
authors.initials: A
authors.lastname: Rovirosa
authors.forename: J
authors.initials: J
authors.lastname: Bellmunt
authors.forename: A
authors.initials: A
authors.lastname: López
authors.forename: M
authors.initials: M
authors.lastname: Fernández
authors.forename: M
authors.initials: M
authors.lastname: Guerra
authors.forename: J
authors.initials: J
authors.lastname: Montagut
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000401:mortality*; D012189:Retrospective Studies; D016019:Survival Analysis
vernacular_title: Incidencia de segundas neoplasias en el cáncer de laringe avanzado. Impacto sobre la supervivencia.