title: Graphical representations of the class I MHC cleft.
abstract: We describe computer graphics and computer aided manufacture of three-dimensional models designed specifically to elucidate the cleft in the class I human leukocyte antigen. The models evolve from computer graphical representations and provide a geometrically and chemically concise and detailed view of the antigen binding site. The techniques provide a new approach to representations of binding sites. The model provides sufficient detail to support binding specificities analysis of active sites involved in protein and DNA binding.
authors.affiliation: Department of Mathematics, Iowa State University, Ames 50011.
authors.forename: J L
authors.initials: JL
authors.lastname: Cornette
authors.forename: B L
authors.initials: BL
authors.lastname: King
authors.forename: M D
authors.initials: MD
authors.lastname: Silverman
authors.forename: C
authors.initials: C
authors.lastname: DeLisi
mesh_terms: D001665:Binding Sites; D003196:Computer Graphics; D004563:Electrochemistry; D015234:HLA-A Antigens / Q000737:chemistry*; D015789:HLA-A2 Antigen / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation
chemical_list: D015234:HLA-A Antigens; C053029:HLA-A*68 antigen; D015789:HLA-A2 Antigen