Identification of natural killer enhancing factor as a major antioxidant in human red blood cells.
Human natural killer enhancing factor genes (NKEF-A and B) share extensive homology with several genes from other organisms known to be induced by oxidative stress and to protect organisms and proteins from oxidative destruction. In this study, we have identified natural killer enhancing factor as an abundant protein in red blood cell cytosol. Highly purified natural killer enhancing factor blocks inactivation of enzymes by mixed metal-thiol oxidation. Thus, natural killer enhancing factor is a major antioxidant protecting red blood cells from oxidative injuries.
Shau
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H
Division of Surgical Oncology, UCLA Medical Center 90024-1782.
Kim
A
A
D000975:Antioxidants; D001483:Base Sequence; D001798:Blood Proteins / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006801:Humans; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D010544:Peroxidases; D054464:Peroxiredoxins
D000975:Antioxidants; D001798:Blood Proteins; D006360:Heat-Shock Proteins; D010544:Peroxidases; C086065:PRDX2 protein, human; D054464:Peroxiredoxins