title: Relationship between hyperlipidemia, lipid mediators, and progressive glomerulosclerosis in the nephrotic syndrome.
abstract: Nephrotic syndrome is defined by proteinuria, hypoalbuminemia, edema and hypercholesterolemia. Evidence from both the experimental and clinical literature suggests that high lipid levels are not only a marker of disease, but also contribute to the process of glomerulosclerosis. Lipid mediators, including eicosanoids, platelet-activating factor, and chemotactic factors, can contribute by effecting leukocyte infiltration, mesangial proliferation, extracellular matrix protein production, vasoreactivity, and coagulation. Infiltrating macrophages may play a central role in these processes. Therapeutic maneuvers aimed at the correction of lipid abnormalities may halt or slow the progression of nephrotic syndrome to end-stage renal disease.
authors.affiliation: Department of Pediatrics, Milton S. Hershey Medical Center, Hershey, PA 17033.
authors.forename: D
authors.initials: D
authors.lastname: Kees-Folts
authors.forename: J R
authors.initials: JR
authors.lastname: Diamond
mesh_terms: D000818:Animals; D015777:Eicosanoids / Q000502:physiology; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D008264:Macrophages / Q000502:physiology; D009404:Nephrotic Syndrome / Q000150:complications* / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D010972:Platelet Activating Factor / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D015777:Eicosanoids; D010972:Platelet Activating Factor; D016212:Transforming Growth Factor beta