title: Comparison of two methods of i.v. insulin administration in the diabetic patient during the perioperative period.
abstract: We have examined the effects of two types of insulin therapy (continuous i.v. infusion (group A: 1.25 u. h-1) and direct i.v. bolus administration of 10 u. every 2 h (group B: 10 u./2 h)) on the metabolic and endocrine responses to surgery in 60 adult diabetic patients undergoing general anaesthesia for elective procedures. Blood glucose concentrations were measured every 15 min from just before induction of anaesthesia until 2 h after surgery. Plasma ketone bodies, lactate, pyruvate, insulin, C-peptide and counter-regulatory hormone concentrations were measured also. Blood glucose concentrations were comparable in both groups, except at 60 min, because of fluctuating blood glucose concentrations in group B. In each group, one patient became hyperglycaemic. One case of hypoglycaemia occurred in group B. There were no statistically significant differences for the other data except for C-peptide. We conclude that, during the operative period, the administration of a direct i.v. bolus of insulin 10 u. every 2 h is a simple and effective method to control blood glucose concentrations; the method can be used when an insulin infusion pump is not available.
authors.affiliation: Department of Anaesthesia, Hôpital Saint-Roche, Centre Hospitalier et Universitaire, Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Raucoules-Aime
authors.forename: C
authors.initials: C
authors.lastname: Ichai
authors.forename: L J
authors.initials: LJ
authors.lastname: Roussel
authors.forename: M J
authors.initials: MJ
authors.lastname: Romagnan
authors.forename: P
authors.initials: P
authors.lastname: Gastaud
authors.forename: C
authors.initials: C
authors.lastname: Dolisi
authors.forename: D
authors.initials: D
authors.lastname: Grimaud
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin