Adrenal renin is localized in lysosomal granules.
Both renin and cathepsin B were co-localized in identical granules of adreno-cortical cells. At day 16 of gestation, many renin-containing granules were observed and gold particles showed homogeneous intragranular distribution; whereas, those for cathepsin B was distributed heterogeneously. At day 18 of gestation, renin immunoreactivity was decreased or undetectable, whereas cathepsin B was still demonstrated at the same level as on day 16 of gestation.
Kon
Y
Y
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Hashimoto
Y
Y
Sugimura
M
M
Murakami
K
K
D000302:Adrenal Cortex / Q000737:chemistry* / Q000196:embryology / Q000648:ultrastructure; D000818:Animals; D002401:Cathepsin B / Q000032:analysis; D005333:Fetus / Q000737:chemistry; D007150:Immunohistochemistry; D008247:Lysosomes / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D016253:Microscopy, Immunoelectron; D012083:Renin / Q000032:analysis*
D002401:Cathepsin B; D012083:Renin