[The pharmacokinetics of propranolol when used with the propercuten transdermal therapeutic system (experimental data)].
The pharmacokinetic studies of propranolol following the application of the propercuten transdermal therapeutic system were performed in conscious rabbits previously assigned to 3 groups. Different forms of propercuten (forte and mite) were used in different groups, different areas of its application being employed. Pulsed intravenous injections of propranolol were given to Group 1 rabbits to conduct another series of pharmacokinetic studies. The rate of drug administration to the systemic bed was 0.08 mg/h per cm propercuten. The constant injection rate was maintained during 5 days, but when propercuten was withdrawn the elimination time of propranolol was 24 hours.
Piotrovskiĭ
V K
VK
Belolipetskaia
V G
VG
Vasil'ev
A E
AE
Shorr
V A
VA
Chichenkov
O N
ON
Fel'dshteĭn
M M
MM
Metelitsa
V I
VI
D000279:Administration, Cutaneous; D000818:Animals; D001702:Biopharmaceutics; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D011433:Propranolol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D013997:Time Factors
D011433:Propranolol
Farmakokinetika propranolola pri primenenii transdermal'noĭ terapevticheskoĭ sistemy properkutena (éksperimental'nye dannye).