Effects of alprazolam on a model of human absences--rhythmic metrazol activity in rats.
Two doses of alprazolam (0.1 and 0.5 mg.kg-1) were tested against a model of human absences--rhythmic EEG activity elicited by low doses of pentylenetetrazol (35 mg.kg-1)--in 10 unrestrained rats with implanted cortical electrodes. Alprazolam delayed the onset of epileptic EEG activity, decreased the number of rhythmic episodes and shortened the total duration of rhythmic activity in a dose-dependent manner. The average duration of episodes of rhythmic activity remained unchanged; other benzodiazepines studied previously were able to influence this measure.
Kubová
H
H
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Mares
P
P
D000525:Alprazolam / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010433:Pentylenetetrazole; D010507:Periodicity; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time
D010433:Pentylenetetrazole; D000525:Alprazolam