Odd-numbered medium-chain triglycerides (trinonanoin) in total parenteral nutrition: parameters of carbohydrate and protein metabolism.
To investigate the metabolic effects of intravenously administered odd-numbered medium-chain triglycerides in healthy non-stressed animals, trinonanoin/long-chain triglyceride (LCT) (7/3) fat emulsions were given in a high dose (46.5% energy) to rabbits (n = 8) for 11 days within a total parenteral nutrition regimen. In comparison with medium-chain triglyceride (MCT)/LCT fat emulsions, higher plasma glucose (day 4), plasma lactate and pyruvate (day 11) and liver glycogen concentrations were found for the test group, indicating a glucogenic effect of the trinonanoin/LCT emulsion. With the present study design, nitrogen balance of the rabbits was not significantly influenced by the kind of fat emulsion administered.
Linseisen
J
J
Institute of Nutrition Science, Technical University of Munich, FRG.
Wolfram
G
G
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005217:Fat Emulsions, Intravenous; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D011817:Rabbits; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D007773:Lactates; D011773:Pyruvates; D014280:Triglycerides; C031461:tripelargonin; D019344:Lactic Acid; D019289:Pyruvic Acid; D006003:Glycogen; D009584:Nitrogen