title: The effects of cisapride on the restoration of gut motility after surgery of the small intestine in horses; a clinical trial.
abstract: Seventy horses surgically treated for colic caused by disorders of the small intestine were included in a randomized blind trial to determine the effects of cisapride (0.1 mg/kg bw intramuscularly at 8-h intervals) on the post-operative restoration of gut motility. Cisapride appeared to reduce the incidence of post-operative ileus. It accelerated the restoration of bowel motility, reducing the period of post-operative intensive care. It is concluded that cisapride is an effective and useful drug in the post-operative treatment of horses after surgery of the small intestine.
authors.affiliation: Department of General and Large Animal Surgery, State University of Utrecht, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: van der Velden
authors.forename: W R
authors.initials: WR
authors.lastname: Klein
mesh_terms: D000818:Animals; D020117:Cisapride; D003085:Colic / Q000601:surgery / Q000662:veterinary*; D004311:Double-Blind Method; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology; D006734:Horse Diseases / Q000601:surgery*; D006736:Horses; D007410:Intestinal Diseases / Q000601:surgery / Q000662:veterinary*; D007421:Intestine, Small / Q000601:surgery*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride