Optimum use of a spacer device.
Nedocromil sodium given by the Fisonair spacer should be inhaled immediately. Multiple actuations into the spacer should be avoided. Delay of 20 seconds before sampling reduced the amount of drug available for inhalation in the respirable range by 81%. Placing two actuations into the spacer reduced the amount of drug available by 47%.
Barry
P W
PW
Department of Child Health, University of Leicester.
Robertson
C F
CF
O'Callaghan
C
C
D000280:Administration, Inhalation; D000336:Aerosols; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006801:Humans; D017835:Nedocromil / Q000008:administration & dosage*
D000336:Aerosols; D000894:Anti-Inflammatory Agents, Non-Steroidal; D017835:Nedocromil