Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP.
Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins.
Saito
M
M
Department of Cellular and Molecular Biology, University of Tokyo, Japan.
Moritoyo
T
T
Park
J H
JH
Lee
B I
BI
Kim
J S
JS
Fujisawa
J
J
Osame
M
M
Yoshida
M
M
D000328:Adult; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology*
D004279:DNA, Viral; D015335:Molecular Probes