[The beta-carotene stimulation of cellular immunity reactions in mice].
The immunomodulating properties of synthetic beta-carotene were studied in C57Bl/6 and BALB/c mice using the tests of proliferative, cytotoxic and suppressor activity, and evaluating the adhesive capacity of macrophage lineage cells. Long-term feeding of C57Bl/6 mice with beta-carotene microgranules (0.1-0.5 mg of active substance per mouse) led to enhanced T cell proliferative response to ConA, which lasted for 15-45 days. Administration of beta-carotene oil solution to BALB/c mice previously immunized with alloantigens (0.17-0.34 mg of beta-carotene per mouse) enhanced T-cell cytotoxicity against L-929 and YAC-1 cells and macrophage cytotoxicity against L-929 cells. The treatment also reduced T-suppressor activity as shown in the assays of inhibition of the lymphocyte blast transformation reaction and mixed lymphocyte culture. The treatment with both preparations of beta-carotene enhanced the adhesive properties of macrophages and related cells, and induced the increased production of oxygen active radicals by these cells.
Abronina
I F
IF
Ramanauskaĭte
R Iu
RIu
Andreĭchuk
T N
TN
Rytenko
A N
AN
Korostelev
S A
SA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007108:Immune Tolerance / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D019207:beta Carotene
D000276:Adjuvants, Immunologic; D019207:beta Carotene; D002338:Carotenoids
Stimuliatsiia beta-karotinom reaktsiĭ kletochnogo immuniteta u mysheĭ.