title: A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic indices.
abstract: This study investigated potential therapeutic differences between Amlodipine 5 mg and Felodipine ER 10 mg in 12 normotensive/borderline hypertensive subjects by comparison of the plasma drug concentration-time profiles and the blood pressure and heart rate responses. There was significantly less trough-to-peak variability in plasma drug concentrations with amlodipine with a ratio of 67%, compared to 37% for felodipine. Correspondingly there was less variability with amlodipine in the blood pressure reductions across the dosage interval. Overall, amlodipine displayed a more consistent hypotensive effect across 24 hours and lower blood pressure values at trough, i.e. 24 hours post-dose.
authors.affiliation: Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Bainbridge
authors.forename: O
authors.initials: O
authors.lastname: Herlihy
authors.forename: P A
authors.initials: PA
authors.lastname: Meredith
authors.forename: H L
authors.initials: HL
authors.lastname: Elliott
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000493:pharmacokinetics* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D003692:Delayed-Action Preparations; D015736:Felodipine / Q000493:pharmacokinetics* / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003692:Delayed-Action Preparations; D017311:Amlodipine; D015736:Felodipine