title: [Primary biliary cirrhosis: symptoms, laboratory data and diagnosis].
abstract: The most frequent and important symptoms in primary biliary cirrhosis (PBC) are pruritus and jaundice. In the majority, jaundice appears within one half to two years of onset of pruritus. Xanthoma, bone change and sicca syndrome are often observed. The recent increase in number of asymptomatic PBC is the result of progagation of medical examination. In the biochemical tests, elevation of the biliary enzymes, such as ALP and gamma-GTP, is characteristic, as well as, a high level of serum IgM. Serum bilirubin values are gradually raised along with the clinical course of the disease. Positive antimitochondrial antibody (AMA) is the most valuable immunological finding for the diagnosis of PBC. Anti-pyruvate dehydrogenase complex E2 component E2 has the same significance as AMA. Diagnostic criteria si shown in this paper.
authors.affiliation: Third Department of Internal Medicine, Miigata University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kamimura
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Tashiro
mesh_terms: D006801:Humans; D007565:Jaundice / Q000209:etiology; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*; D008111:Liver Function Tests / Q000379:methods; D011537:Pruritus / Q000209:etiology