title: Use of X-linked clonal analysis in acute promyelocytic leukemia.
abstract: X-linked clonal analysis (XLCA) either using Glucose-6-phosphate dehydrogenase (G-6-P-D) polymorphisms or restriction fragment length polymorphisms (RFLP) and methylation analysis has provided considerable understanding of haematologic malignancy. Acute Promyelocytic Leukemia (APL) is characterized by a unique cytogenetic translocation t(15;17), frequent achievement of remission without a preceding phase of marrow hypocellularity after induction chemotherapy and a high rate of clinical response to all-trans retinoic acid (ATRA). In limited studies XLCA has provided insight into the pathogenesis and mechanism of drug action in this disease.
authors.affiliation: Department of Haematology, Mater Misericordiae Hospitals, Brisbane, Australia.
authors.forename: K M
authors.initials: KM
authors.lastname: Taylor
authors.forename: R L
authors.initials: RL
authors.lastname: Rodwell
authors.forename: S L
authors.initials: SL
authors.lastname: Elliott
authors.forename: D L
authors.initials: DL
authors.lastname: Taylor
mesh_terms: D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D014212:Tretinoin / Q000627:therapeutic use; D014410:Tumor Stem Cell Assay; D014960:X Chromosome
chemical_list: D014212:Tretinoin