Adrenergic activity of methyl-alpha-(p-nitrophenyl)-beta-(1-pyrrolidinyl) propionate.
alpha-(p-nitrophenyl)-beta-(1-pyrrolidinyl) propionic acid and its methyl ester were prepared and their structures were assigned by elemental analysis, 1H-NMR and IR spectroscopy. The methyl ester derivative was tested in the following pharmacological assays: 1) Acute toxicity; 2) effect on the cat nictitating membrane; 3) effect on the isolated rat uterus; 4) Cardiovascular effects were studied by experiments on arterial pressure in dogs and cats as well as heart rate; 5) Locomotor activity in mice was explored and 6) The effects on the central nervous system in rabbits was studied by electroencephalography. The results showed that this compound presents alpha and beta adrenergic activity in the experimental preparations studied.
Riera de Narvaez
A J
AJ
Departamento de Farmacognosia y Medicamentos Orgánicos, Facultad de Farmacia, Universidad de Los Andes, Mérida-Venezuela.
Vicuña Fernández
N
N
D000818:Animals; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013566:Sympathomimetics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D010648:Phenylacetates; D011759:Pyrrolidines; D013566:Sympathomimetics; C086100:methyl alpha-(4-nitrophenyl)-beta-(1-pyrrolidinyl)propionate