Effects of positive acceleration on atrial natriuretic peptide in humans.
To study the effects of positive acceleration on the plasma atrial natriuretic peptide (ANP) and renin concentration (PRC), students of the Korean Air Force Academy and pilots were exposed to +6 Gz for 30 s in a human centrifuge without anti-G suits. An acceleration to +6 Gz caused a significant increase (p < 0.01) in the heart rate of both the student and pilot groups. We performed blood collection within 2 min after terminating centrifugation. Systolic blood pressure was increased significantly (p < 0.01), and heart rates were elevated and did not return to control levels by 2 min after centrifugation. Plasma ANP decreased significantly in both groups (p < 0.05). The difference in the percentage of ANP decrement was not significant between student and pilot groups. PRC increased significantly (p < 0.05) in both groups. This study demonstrated that high +Gz exposure in man caused a significant reduction of plasma ANP concentration, although PRC, heart rate, and blood pressure increase.
Park
J K
JK
Aeromedical Training Center, ROKAF, Cheungwon, Republic of Korea.
Seul
K H
KH
Park
B O
BO
Kim
S H
SH
Cho
K W
KW
D000054:Acceleration; D000328:Adult; D000337:Aerospace Medicine; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D006112:Gravitation; D006339:Heart Rate; D006801:Humans; D012083:Renin / Q000097:blood
D009320:Atrial Natriuretic Factor; D012083:Renin