Influence of salt intake on the antihypertensive effect of carvedilol.
OBJECTIVE
To investigate whether moderate sodium restriction can increase the proven antihypertensive effect of carvedilol, a newly developed beta-blocker with vasodilating properties.


METHODS
A randomly allocated double-blind crossover in 19 patients.


RESULTS
Lowering dietary salt increased the fall in blood pressure obtained with carvedilol.
Ruilope
L M
LM
Hypertension Unit, 12 de Octubre Hospital, Madrid, Spain.
Lahera
V
V
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology / Q000627:therapeutic use*; D000077261:Carvedilol; D004039:Diet, Sodium-Restricted; D004311:Double-Blind Method; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011412:Propanolamines / Q000494:pharmacology / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002227:Carbazoles; D011412:Propanolamines; D014665:Vasodilator Agents; D000077261:Carvedilol