title: Treatment of disseminated intravascular coagulation with gabexate mesilate.
abstract: Gabexate mesilate (FOY) was used to treat 215 patients with disseminated intravascular coagulation (DIC) and 146 patients with a predisposition to DIC (pre-DIC). Sixty percent of DIC patients and 48% of pre-DIC patients exhibited pretreatment organ failure, which resolved after FOY treatment in 16% of DIC patients and 17% of pre-DIC patients. Seventy percent of DIC patients and 49% of pre-DIC patients had a pretreatment bleeding tendency that was ameliorated by FOY treatment in 32% of DIC patients and 30% of pre-DIC patients. Comparison of pretreatment and posttreatment hemostatic studies of the DIC patients revealed that platelet count and levels of fibrinogen degradation products (FDP), thrombin-antithrombin-III complex, and FDP-D-dimer decreased significantly; fibrinogen level increased markedly; and prothrombin time was prolonged. DIC scores were significantly lowered in both leukemic and nonleukemic patients from the third day of treatment with FOY. Among leukemic DIC patients, 59% showed complete remission (CR), 21% partial remission (PR), and 7% exacerbation of their condition; 46% of the nonleukemic DIC patients demonstrated CR, 17% PR, and 17% exacerbation. Of the leukemic pre-DIC patients, 59% showed improvement and 7% exacerbation, whereas 55% of the nonleukemic pre-DIC patients showed improvement and 27% exacerbation.
authors.affiliation: Second Department of Internal Medicine, Mie University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tamaki
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Hiyoyama
authors.forename: M
authors.initials: M
authors.lastname: Shimura
authors.forename: K
authors.initials: K
authors.lastname: Minamikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Wakita
authors.forename: T
authors.initials: T
authors.lastname: Nakase
authors.forename: M
authors.initials: M
authors.lastname: Ohiwa
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: E
authors.initials: E
authors.lastname: Iwasaki
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D005260:Female; D016670:Gabexate / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000150:complications
chemical_list: D016670:Gabexate