Uptake of ascorbic acid by human neutrophils.
Human neutrophils produce bacterial oxidants that could have a damaging effect on the neutrophils themselves. For protection, neutrophils acquire a high (10-20 mmol/L) level of intracellular ascorbic acid by oxidizing extracellular ascorbic acid to dehydroascorbic acid, rapidly taking up the dehydroascorbic acid and re-reducing it to ascorbic acid.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720.
D001205:Ascorbic Acid / Q000378:metabolism*; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction
D001205:Ascorbic Acid