title: Combined use of cerebral spinal fluid drainage and naloxone reduces the risk of paraplegia in thoracoabdominal aneurysm repair.
abstract: OBJECTIVE
  This report summarizes our experience with the use of cerebral spinal fluid drainage (CSFD) and naloxone for prevention of postoperative neurologic deficit (paraplegia or paraparesis).
  
  
  METHODS
  We reviewed 110 consecutive patients with 86 thoracoabdominal aneurysms and 24 thoracic aneurysms. The status of 47 patients (43%) was acute (rupture or dissection), and the status of 52 (47%) was Crawford type I or II. None of the patients had intercostal artery reimplantation. There were two patient groups for analysis of neurologic deficit risk. Group A (61 patients) received naloxone and CSFD, and group B (49 patients) did not.
  
  
  RESULTS
  One deficit occurred in group A and 11 deficits occurred in group B (p = 0.001). By multiple logistic regression analysis, the variables acute status, Crawford type II, or group B classification were significant factors for deficit risk. Use of the same logistic regression analysis on the subgroup of 47 patients with acute aneurysms and 33 patients with Crawford type 2 aneurysms confirmed the protective effect of combined CSFD and naloxone (group A) and that clinical presentation and extent of aorta replaced are the primary risk factors for development of deficit. To test this conclusion we developed a highly predictive model (correlation coefficient 0.997 with 16 series of thoracoabdominal aneurysms) for neurologic deficit. We applied our data to this model. Group B had the predicted number of deficits, and group A had substantially fewer deficits than predicted.
  
  
  CONCLUSIONS
  We conclude that the combined use of CSFD and naloxone offers significant protection from neurologic deficits in patients undergoing thoracoabdominal and thoracic aortic replacement.
authors.affiliation: University of Wisconsin Hospital, Madison.
authors.forename: C W
authors.initials: CW
authors.lastname: Acher
authors.forename: M M
authors.initials: MM
authors.lastname: Wynn
authors.forename: J R
authors.initials: JR
authors.lastname: Hoch
authors.forename: P
authors.initials: P
authors.lastname: Popic
authors.forename: J
authors.initials: J
authors.lastname: Archibald
authors.forename: W D
authors.initials: WD
authors.lastname: Turnipseed
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D017544:Aortic Aneurysm, Abdominal / Q000145:classification / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000145:classification / Q000401:mortality / Q000601:surgery*; D002555:Cerebrospinal Fluid; D003131:Combined Modality Therapy; D004322:Drainage / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use*; D010264:Paraplegia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D009270:Naloxone