title: [Hypernephroma and associated AL-amyloidosis with polyneuropathy in monoclonal gammopathy].
abstract: Malignant neoplasms may have secondary (reactive, AA), amyloidosis as a sequel. Among carcinomas, this is most frequent with hypernephroma. We report a 60-year-old male patient with progressive polyneuropathy and monoclonal gammopathy of the kappa type. A renal tumor was histologically diagnosed as hypernephroma at nephrectomy. The patient did not improve postoperatively and died three and a half months later from pulmonary embolism. Autopsy revealed a systemic amyloidosis, predominantly with prominent deposits in peripheral nerves. Immunohistochemical staining demonstrated the amyloidosis as of the primary (AL) type, rather than of the expected AA type. A plasmocytoma was not detected, either clinically or at autopsy. We assume here a coincidental rather than causal connection between the hypernephroma and the monoclonal gammopathy with AL amyloid and the neuropathy.
authors.affiliation: Neurologische Abteilung, Markusovszky Krankenhaus, Szombathely, Ungarn.
authors.forename: F
authors.initials: F
authors.lastname: Garzuly
authors.forename: E
authors.initials: E
authors.lastname: Meszaros
authors.forename: F
authors.initials: F
authors.lastname: Brittig
authors.forename: Z
authors.initials: Z
authors.lastname: Viniczai
authors.forename: M
authors.initials: M
authors.lastname: Mazlo
authors.forename: H
authors.initials: H
authors.lastname: Budka
mesh_terms: D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D001797:Blood Protein Electrophoresis; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications* / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology; D011115:Polyneuropathies / Q000150:complications* / Q000473:pathology
chemical_list: D000682:Amyloid; C035222:amyloid protein AL
vernacular_title: Hypernephrom und assoziierte AL-Amyloidose mit Polyneuropathie bei monoklonaler Gammopathie.