title: Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro.
abstract: The effect of ethanol on hepatic lipoprotein secretion is not fully understood. This study shows that exposure of HepG2 cells to ethanol significantly increases intracellular apolipoprotein B, apo B mRNA and secreted apolipoprotein B. No other agent has been shown to produce such an increase in apolipoprotein B synthesis or apolipoprotein B mRNA levels.
authors.affiliation: Department of Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK.
authors.forename: T W
authors.initials: TW
authors.lastname: Wang
authors.forename: C D
authors.initials: CD
authors.lastname: Byrne
authors.forename: C N
authors.initials: CN
authors.lastname: Hales
mesh_terms: D001055:Apolipoproteins B / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D018197:Hepatoblastoma; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008113:Liver Neoplasms; D012333:RNA, Messenger / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D001055:Apolipoproteins B; D012333:RNA, Messenger; D000431:Ethanol