title: Histological evaluation of thyroid carcinomas: reproducibility of the "WHO" classification.
abstract: OBJECTIVE
  Thyroid carcinomas display several pathologic features, show different behavior and necessitate different treatment; thus correct classification is mandatory.
  
  
  METHODS
  The kappa statistic was used as a measure of agreement in a panel of seven pathologists who reviewed 200 cases of thyroid tumors.
  
  
  RESULTS
  Overall agreement was 83% (k = 68). Good agreement was found for anaplastic (k = 0.85) and papillary carcinomas (k = 0.81); agreement for medullary carcinoma was acceptable (k = 0.80), suboptimal for other (k = 0.67), and poor for follicular carcinoma (k = 0.54).
  
  
  CONCLUSIONS
  Central pathology review of thyroid carcinomas is recommended when clinical and epidemiologic trials are planned.
authors.affiliation: Institute of Pathology, University of Padua, Italy.
authors.forename: A S
authors.initials: AS
authors.lastname: Fassina
authors.forename: M C
authors.initials: MC
authors.lastname: Montesco
authors.forename: V
authors.initials: V
authors.lastname: Ninfo
authors.forename: P
authors.initials: P
authors.lastname: Denti
authors.forename: G
authors.initials: G
authors.lastname: Masarotto
mesh_terms: D006801:Humans; D015203:Reproducibility of Results; D013964:Thyroid Neoplasms / Q000145:classification / Q000473:pathology*; D014944:World Health Organization