Intracytoplasmic inclusion bodies of erythrocyte origin within hepatocytes in a hepatic allograft.
Intracytoplasmic inclusion bodies with an unusual immunohistochemical profile, histologically similar to alpha 1 antitrypsin globules and megamitochondria, were seen within hepatocytes in a liver allograft biopsy. Electron microscopy revealed that these structures were erythrocytes in various stages of degradation. Their appearance following an episode of Pneumocystis carinii pneumonia suggests a possible relationship between bouts of hypoxia and erythrocyte entry into hepatocytes.
Khettry
U
U
Department of Pathology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Federman
M
M
O'Hara
C J
CJ
Landis
W J
WJ
D000328:Adult; D004577:Electron Probe Microanalysis; D004912:Erythrocytes / Q000737:chemistry / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry / Q000648:ultrastructure*; D007501:Iron / Q000032:analysis; D008099:Liver / Q000648:ultrastructure*; D016031:Liver Transplantation / Q000473:pathology*; D014184:Transplantation, Homologous
D007501:Iron