title: Intestinal absorption of manganese: an in vitro study.
abstract: Our work on isolated rat intestine aimed at studying the hypothesis that the intestinal transport of manganese was carrier-mediated and, consequently, subjected to saturation. Our results confirm this hypothesis, assessing the concentration of carrier saturation for manganese at 0.5 mM. As this concentration, which may determine self-limitation in the intestinal absorption of this metal, is much higher than the maximal allowed concentration of the EEC Standard (50 mg/l), food and water should be carefully monitored for their manganese content in order to avoid reaching toxic concentrations in blood and tissues.
authors.affiliation: Department of Food Science and Microbiology, University of Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Testolin
authors.forename: S
authors.initials: S
authors.lastname: Ciappellano
authors.forename: A
authors.initials: A
authors.lastname: Alberio
authors.forename: F
authors.initials: F
authors.lastname: Piccinini
authors.forename: L
authors.initials: L
authors.lastname: Paracchini
authors.forename: A
authors.initials: A
authors.lastname: Jotti
mesh_terms: D000818:Animals; D005260:Female; D007408:Intestinal Absorption; D007700:Kinetics; D008345:Manganese / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008345:Manganese