A study on the antigenic nature of circulating immune complexes in hemolytic uremic syndrome: no evidence of platelet membrane glycoprotein antigens.
Circulating immune complexes (CIC) have been described in the hemolytic uremic syndrome (HUS) in children. They may represent an epiphenomenon or could be related to the platelet activation and endothelial damage observed in this disease. In an attempt to define this relationship, we investigated the CIC isolated in 17 patients with the classic form of HUS, by means of monoclonal antibodies against platelet surface glycoprotein Ib and IIb-IIIa complex. The negative results obtained do not support the possibility of platelet antigens being constituents of CIC and make an antibody-induced platelet activation in HUS very unlikely.
Olavarria
F
F
Division of Nephrology, School of Medicine, Universidad Austral de Chile, Valdivia.
Pereira
J
J
Mezzano
S
S
Kunick
M
M
Castillo
A
A
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex / Q000097:blood* / Q000276:immunology*; D000941:Antigens / Q000097:blood*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D015539:Platelet Activation / Q000276:immunology; D010980:Platelet Membrane Glycoproteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000941:Antigens; D010980:Platelet Membrane Glycoproteins