[The effect of immunosuppressive substances on the zinc content in cells].
Decreases in zinc levels in the cells of various organs were observed in mice received cyclosporin A and sodium diethyldithiocarbamate. Glucocorticoid therapy induced a decrease of zinc levels in the granulocytes of human peripheral blood. The role of alterations in cell zinc metabolism in the mechanism of action of immunosuppressive agents is discussed in the paper.
Gol'berg
E D
ED
Eshchenko
V A
VA
Bovt
V D
VD
Tolok
A Ia
AIa
D000818:Animals; D005938:Glucocorticoids / Q000627:therapeutic use; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D015032:Zinc / Q000378:metabolism*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D015032:Zinc
Vliianie immunosupressivnykh veshchestv na soderzhanie tsinka v kletkakh.