[Anxiolytic activities of pentanthrene type heterocyclic compounds].
A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.
Imamura
T
T
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Noda
A
A
Shibata
S
S
Watanabe
S
S
Noda
H
H
Ono
Y
Y
Goto
S
S
Inoue
Y
Y
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D006571:Heterocyclic Compounds