[The comparative efficacy of the membrane-protective action of piracetam and nikogamol in chronic stress].
It has been established that prophylactic doses of piracetam (500 mg/kg) and nicogamol (10 mg/kg) for 10 days prevent disorders in the morphofunctional status of membranes of brain mitochondria and erythrocytes due to stress. The membranoprotective effect which is more pronounced in nicogamol is shown by suppressing the activation of lipid peroxidation, nonspecific protection of the cell antioxidative system, by stabilizing the qualitative and quantitative relationships of structural components of a lipid matrix, and by subsequently normalizing the activity of membranous marker enzymes.
Kresiun
V I
VI
Rozhkovskiĭ
Ia V
IaV
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000502:physiology; D007425:Intracellular Membranes / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000648:ultrastructure; D009539:Nicotinic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
D009539:Nicotinic Acids; C041555:nikogamol; D010889:Piracetam
Sravnitel'naia éffektivnost' membranoprotektornogo deĭstviia piratsetama i nikogamola v usloviiakh khronicheskogo stressa.