title: Effects of liposome-entrapped adenosine in the isolated rat aorta.
abstract: This study examined the effects of adenosine- and adenosine deaminase-loaded liposomes upon the contractile activity of the vascular smooth muscle, using the isolated, de-endothelised rat aorta ring as in vitro model. While control liposomes had no effect, intraliposomal adenosine (5 x 10(-3) M) induced contraction of the preparation. Intraliposomal adenosine deaminase induced partial relaxation of high K(+)-precontracted rings. The adenosine-induced contraction seems to involve Ca2+ influx through L-type channels as an essential component, but protein kinase C may also have a modulatory role.
authors.affiliation: Department of Physiology, University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Brailoiu
authors.forename: D N
authors.initials: DN
authors.lastname: Serban
authors.forename: S
authors.initials: S
authors.lastname: Slatineanu
authors.forename: C M
authors.initials: CM
authors.lastname: Filipeanu
authors.forename: B C
authors.initials: BC
authors.lastname: Petrescu
authors.forename: D D
authors.initials: DD
authors.lastname: Branisteanu
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000243:Adenosine Deaminase / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D015220:Calcium Channels / Q000502:physiology; D004337:Drug Carriers; D066298:In Vitro Techniques; D008081:Liposomes; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats
chemical_list: D015220:Calcium Channels; D004337:Drug Carriers; D008081:Liposomes; D011493:Protein Kinase C; D000243:Adenosine Deaminase; D000241:Adenosine; D011188:Potassium