[The participation of the renin-angiotensin system in regulating noradrenaline inactivation in the lungs during blood loss].
The previous study demonstrated that there are two stages in acute posthemorrhagic reaction (blood loss 1.5% of body weight) when cardiac output remains low: 1) increase of lung inactivation of norepinephrine (LIN) during the first 5 min after hemorrhage; 2) decrease of LIN 10 min after hemorrhage. The present study investigated effect of captopril (1 mg/kg, i.v.) at the second stage of this reaction. Captopril prevented posthemorrhagic decrease of LIN. It is proposed that angiotensin II inhibits LIN in hemorrhage.
Bonetskiĭ
A A
AA
Fedorov
V I
VI
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology*; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000097:blood; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D000804:Angiotensin II; D002216:Captopril; D009638:Norepinephrine
Uchastie renin-angiotenzinnoĭ sistemy v reguliatsii inaktivatsii noradrenalina v legkikh pri krovopotere.