[The fibrinolytic system and total parenteral nutrition].
A study is presented which was carried out in twenty-five patients operated on in a surgical service, and who received total parenteral nutrition. Samples were taken to check modifications to the fibrinolytic system occurring after administration of hyperosmotic solutions, principally lipidic emulsions, from a contemporary standpoint. We performed three extractions: on day one, day five and following the withdrawal of the fat emulsion, with study of modifications to antithrombin III, alpha 2 antiplasmin, plasminogen, C protein, plasminogen tissular activator (t-PA), plasminogen tissular activator inhibitor (PAI 1), fibrinogen, and fibrinogen/fibrin degradation products. The laboratory techniques used are shown, along with the results obtained: increased for alpha 2 antiplasmin and antigenic t-PA with significant values (p < 0.05) on the day of withdrawal in comparison with pre-PN values, plus increased values for plasminogen, fibrinogen/fibrin degradation products and t-PA activity. In conclusion, it is suggested that antithrombin III deficiency, along with reduction in C protein levels and increased fibrinogen and PAI 1 concentration predispose patients with t-PA release defects to thrombo-embolic complication.
Fernández Ruiz
M
M
Servicio de Cirugía, Hospital San Millán, Logroño, España.
Lasierra Cirujeda
J
J
D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D011300:Preoperative Care; D013514:Surgical Procedures, Operative; D013997:Time Factors
D001798:Blood Proteins
Sistema fibrinolítico y nutrición parenteral total.