title: Analysis of genotype and phenotype on the same interphase or mitotic cell. A manual of MAC (morphology antibody chromosomes) methodology.
abstract: The purpose of this paper is to serve as a MAC (Morphology Antibody Chromosome) manual describing combined methodologies that allow simultaneous and/or sequential analysis of cell morphology, immunophenotype, and banded chromosomes and/or in situ hybridization signals. The MAC techniques used at the Department of Medical Genetics of the University of Helsinki, Finland, are described and modifications or related techniques reported by other authors are discussed. A list of references concerning applications is also given.
authors.affiliation: Department of Medical Genetics, University of Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
authors.forename: S J
authors.initials: SJ
authors.lastname: Nylund
authors.forename: M
authors.initials: M
authors.lastname: Wessman
authors.forename: M L
authors.initials: ML
authors.lastname: Larramendy
mesh_terms: D002871:Chromosome Banding; D005455:Fluorescent Antibody Technique; D005821:Genetic Techniques; D005838:Genotype; D006801:Humans; D007038:Hypotonic Solutions; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D007399:Interphase; D008297:Male; D008938:Mitosis; D010641:Phenotype; D012854:Sister Chromatid Exchange
chemical_list: D007038:Hypotonic Solutions