[The antioxidant system in the dynamic combined treatment of epilepsy patients with traditional anticonvulsant preparations and an antioxidant--alpha-tocopherol].
Examination of 13 patients suffering from generalized epilepsy has shown about 20-25% decreases in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GP) in red blood cells. Out of them 9 patients were treated with the antioxidant alpha-tocopherol (600 mg daily). Prior to alpha-tocopherol treatment all patients showed abnormal electroencephalographic (EEG) changes; 4 weeks later the effects of the antioxidant appeared as positive EEG changes, reduced frequency of epileptic seizures, increased SOD activity and patients' improved general state. Thus, the addition of the antioxidant to the multitherapy of epilepsy enhances antioxidative activity and therapeutical effects.
Tupeev
I R
IR
Kryzhanovskiĭ
G N
GN
Nikushkin
E V
EV
Bordiukov
M M
MM
Iuzefova
S M
SM
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D000975:Antioxidants; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004829:Epilepsy, Generalized / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D013997:Time Factors; D014810:Vitamin E / Q000097:blood / Q000627:therapeutic use*
D000927:Anticonvulsants; D000975:Antioxidants; D014810:Vitamin E
Antioksidantnaia sistema v dinamike kompleksnogo lecheniia bol'nykh épilepsieĭ traditsionnymi protivosudorozhnymi preparatami i antioksidantom--al'fa-tokoferolom.