HLA mismatching and cytomegalovirus infection as risk factors for transplant failure in cyclosporin-treated renal allograft recipients.
In a study of the effects on renal allograft survival of HLA mismatching, mismatching for cytomegalovirus (CMV) antibody status, and post-transplant CMV infection, 148 cyclosporin-treated renal transplant recipients were given kidneys optimally matched for HLA-A, -B, and -DR antigens but not matched for CMV antibody status. Mismatching for HLA-B and -DR antigens was associated with a greater number of rejection episodes and a lower graft survival, but mismatching for CMV antibody status and posttransplant primary or recurrent CMV infection exerted no effect on graft survival. The role of matching of renal transplant recipients and donors for CMV antibody status in preference to HLA matching (proposed as a means of reducing the mortality associated with primary CMV infection) is discussed.
Morris
D J
DJ
North Manchester Virus Laboratory, Booth Hall Children's Hospital, UK.
Martin
S
S
Dyer
P A
PA
Hunt
L
L
Mallick
N P
NP
Johnson
R W
RW
D000914:Antibodies, Viral / Q000097:blood; D000961:Antilymphocyte Serum / Q000494:pharmacology; D003168:Complement Fixation Tests; D016572:Cyclosporine / Q000494:pharmacology; D003587:Cytomegalovirus / Q000187:drug effects / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D006084:Graft Rejection / Q000382:microbiology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects; D015235:HLA-B Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006650:Histocompatibility Testing / Q000706:statistics & numerical data; D006801:Humans; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008775:Methylprednisolone / Q000494:pharmacology; D009392:Nephrectomy; D011863:Radioimmunoassay; D006435:Renal Dialysis; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D017201:Virus Shedding
D000914:Antibodies, Viral; D000961:Antilymphocyte Serum; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D016572:Cyclosporine; D008775:Methylprednisolone