title: The expression of a neuronal nuclear antigen (Ri) recognized by the human anti-Ri autoantibody in the developing rat nervous system.
abstract: Anti-Ri is a human autoantibody that recognizes a neuronal nuclear antigen (Ri) of unknown function. To ascertain the possible role of the Ri antigen in neuronal development, we analysed the pattern of the anti-Ri immunoreactivity in the developing rat nervous system. Neurons of the retina, except the photoreceptors, and central but not peripheral nervous system were anti-Ri-positive. The intensity of the immunoreactivity followed the sequence of neuronal maturation. Germinal cells of the periventricular layer and migrating neuroblasts in the intermediate zone were Ri-negative. These data suggest Ri antigen may play a role in the postmigratory maturation of neurons of the CNS.
authors.affiliation: Hospital del Mar, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Fueyo
authors.forename: I
authors.initials: I
authors.lastname: Ferrer
authors.forename: F
authors.initials: F
authors.lastname: Valldeoriola
authors.forename: F
authors.initials: F
authors.lastname: Graus
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm; D001323:Autoantibodies / Q000276:immunology*; D002467:Cell Nucleus / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009419:Nerve Tissue Proteins; D009420:Nervous System / Q000276:immunology*; D000090682:Neuro-Oncological Ventral Antigen; D011247:Pregnancy; D016601:RNA-Binding Proteins / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000166:cytology / Q000254:growth & development / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D001323:Autoantibodies; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins