title: High frequency intergenomic recombination of suid herpesvirus 1 (SHV-1, Aujeszky's disease virus).
abstract: Examples are given of observations made with field isolates of suid herpesvirus 1 (SHV-1) which indicate that intergenomic recombination is a common phenomenon associated with the virus. This was further confirmed by experimental co-infection of a pig with 2 virus strains with different, stable and easily identifiable genomic markers, followed by natural transmission to a group of contact pigs. A variety of recombinants was subsequently isolated, while none of the parental strains were re-isolated from any of the pigs. It is suggested that co-invasion of cells and recombination between viral genomes play a role in the life cycle of the virus.
authors.affiliation: State Veterinary Institute for Virus Research Lindholm, Denmark.
authors.forename: L S
authors.initials: LS
authors.lastname: Christensen
authors.forename: B
authors.initials: B
authors.lastname: Lomniczi
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004279:DNA, Viral / Q000302:isolation & purification; D003718:Denmark / Q000453:epidemiology; D011558:Herpesvirus 1, Suid / Q000235:genetics* / Q000302:isolation & purification; D012150:Polymorphism, Restriction Fragment Length; D011557:Pseudorabies / Q000453:epidemiology / Q000382:microbiology; D011995:Recombination, Genetic; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000382:microbiology; D014765:Viral Vaccines / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014765:Viral Vaccines