Particle contamination in a ternary nutritional admixture.
During total parenteral nutrition, the intravenous infusion of large volumes over a prolonged period of time appears to involve risks of particle contamination for the patients. The aim of this work is to number, measure, and characterize inert particles in a standard ternary mixture prepared by sterile transfer technique. The distribution of particles is studied in each component of the admixture and in the final preparation using two different methods: the Coulter counter and an optical microscopic numbering after filtration. The nature and the origin of particles are determined by the use of scanning electron microscopy (SEM) coupled with a photon X spectrometer.
Foroni
L A
LA
School of Pharmacy, Université Joseph Fourier, Grenoble, France.
Rochat
M H
MH
Trouiller
P
P
Calop
J Y
JY
D005374:Filtration; D005506:Food Contamination; D008855:Microscopy, Electron, Scanning; D010289:Parenteral Nutrition, Total / Q000592:standards*; D010316:Particle Size; D012996:Solutions / Q000032:analysis*
D012996:Solutions