Hyperthyroidism with potent thyroid-stimulation-blocking antibodies and negative thyroid-stimulating antibodies after subtotal thyroidectomy for Graves' disease with follicular thyroid carcinoma.
A 39-year-old woman with Graves' disease associated with follicular thyroid carcinoma underwent subtotal thyroidectomy. TSH-binding inhibitor immunoglobulins (TBII) were positive, whereas thyroid-stimulating antibodies (TSAb) and thyroid-stimulation-blocking antibodies (TSBAb) were both negative before the operation. After the operation, TBII markedly increased above the pretreatment value. TSBAb became positive 3 months after the operation and then their activity increased, while TSAb remained negative after the operation. Subtotal thyroidectomy may have influenced the development of TSBAb in this patient. Irrespective of these findings, the patient became hyperthyroid again several months after the operation.
Sugimoto
M
M
Department of Internal Medicine, Gifu Red Cross Hospital, Japan.
Nakamura
S
S
Hattori
J
J
Yamada
T
T
Horiya
Y
Y
Hara
S
S
Shima
H
H
D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D000242:Cyclic AMP / Q000037:antagonists & inhibitors; D005260:Female; D006111:Graves Disease / Q000601:surgery*; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology*; D018828:Immunoglobulins, Thyroid-Stimulating; D013961:Thyroid Gland / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000276:immunology
D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D013972:Thyrotropin; D000242:Cyclic AMP