[Botulinum toxin for palatal myoclonus and spastic dysphonia].
Botulinum toxin (B; Botox), produced by the anaerobic bacterium Clostridium botulinum, causes temporary paralysis by blocking the presynaptic release of acetylcholine at the neuromuscular junction. This action is clinically used to alleviate muscle spasm by injecting the toxin directly into the overactive muscle. We report our experience with B injections in 2 women, aged 20 and 21, respectively, 1 of whom had bilateral palatal myoclonus and the other adductor spastic dysphonia. Both showed remarkable improvement of conditions for which, until now, we had no effective treatment. These are the first cases in Israel treated with B for otorhinolaryngological conditions.
Greenberg
E
E
Dept. of Otorhinolaryngology, Carmel Hospital, Haifa.
Giladi
N
N
Meer
J
J
Uri
N
N
Honigman
S
S
D000328:Adult; D001905:Botulinum Toxins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009207:Myoclonus / Q000188:drug therapy* / Q000503:physiopathology; D010156:Palatal Muscles; D014832:Voice Disorders / Q000188:drug therapy* / Q000503:physiopathology
D001905:Botulinum Toxins