Polymorphism of pentanucleotide repeats in the 5' flanking region of glutathione S-transferase (GST) pi gene.
The upstream sequence of the glutathione S-transferase pi gene contains pentanucleotide (ATAAA) repeats. Analysis of the region using polymerase chain reaction indicated that the repeat sequence was polymorphic and segregation of the polymorphic alleles was codominant heredity. Heterozygosity of the new VNTR was 0.818 in healthy Japanese and 0.794 in American whites. Allelic frequencies among healthy controls and alcoholics as well as other diseases were not significantly different.
Harada
S
S
Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan.
Nakamura
T
T
Misawa
S
S
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005787:Gene Frequency; D005796:Genes; D005982:Glutathione Transferase / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014481:United States; D044465:White People
D017931:DNA Primers; D009711:Nucleotides; D005982:Glutathione Transferase