title: Selective immunosuppression.
abstract: Experimental models of autoimmune diseases have demonstrated that such disease can be prevented or treated by selectively interfering with activation of any of these cell types: antigen-presenting cells, autoreactive T cells and regulatory T cells. Luciano Adorini and colleagues discuss these approaches to selective immunosuppression and examine how similar strategies may become applicable to the treatment of human autoimmune diseases.
authors.affiliation: Roche Milano Ricerche, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Adorini
authors.forename: J C
authors.initials: JC
authors.lastname: Guéry
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez-Tarduchy
authors.forename: S
authors.initials: S
authors.lastname: Trembleau
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D011948:Receptors, Antigen, T-Cell