Fungicidal and genotoxic activity of new substituted pyridazinones.
Some 2-sulfonyl- and 2-acylderivatives of the 4,5-dichloro-3(2H)-pyridazinone were prepared in order to test their fungicidal activity. Interesting results, both in vitro and in vivo, were obtained in particular from the alkylsulfonyl-derivatives. Genotoxic activity of 3(2H)-pyridazinones was evaluated in vitro by the Bacillus subtilis rec-assay and the Salmonella-microsome reversion assay.
Carmellino
M L
ML
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
Massolini
G
G
Pagani
G
G
Zani
F
F
Leri
G
G
D001412:Bacillus subtilis / Q000235:genetics; D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D010935:Plant Diseases; D011724:Pyridazines / Q000494:pharmacology* / Q000633:toxicity; D011995:Recombination, Genetic / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D004269:DNA, Bacterial; D005659:Fungicides, Industrial; D009153:Mutagens; D011724:Pyridazines; C020458:2-phenyl-4,5-dichloro-3-pyridazinone