Estimation of impurity profiles in drugs and related materials. Part 11--The role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses.
Impurities in drugs are classified on the basis of the types of side-reactions in drug syntheses resulting in their formation. This is shown by summarizing the authors' earlier results in the field of impurity profiling of 19-nor-steroids, ethynodiol diacetate, mazipredone, pipecuronium bromide, flumecinol, enalapril, pyridinol carbamate, phenylbutazone, thymotrinan and some new results related to danazol and famotidine.
Görög
S
S
Chemical Works of G. Richter Ltd., Budapest, Hungary.
Balogh
G
G
Csehi
A
A
Csizér
E
E
Gazdag
M
M
Halmos
Z
Z
Hegedüs
B
B
Herényi
B
B
Horváth
P
P
Laukó
A
A
D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000138:chemical synthesis* / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004364:Pharmaceutical Preparations