Influence of bromfenvinphos alone, and in mixture with methoxychlor, on levels of gamma-glutamyl transpeptidase, ceruloplasmin and cholesterol in the blood plasma of laboratory mice.
Bromfenvinphos [0,0-diethyl-1-(2,4-dichlorophenyl)-2-bromovinyl phosphate], (BrV), 12.33 mg/kg/day alone and in combination with methoxychlor [1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane], (MeOCl), 24.66 mg/kg/day were administered daily per os (intragastrically) in pure olive-oil for 6 weeks to male laboratory mice. The activity of gamma-glutamyl transpeptidase (GGTP), ceruloplasmin (CRP), and cholesterol in the blood plasma were determined. The hematocrit value, the erythrocyte count and the weights of the liver, spleen, heart, kidney and gonads were also measured after the end of treatment. BrV and BrV + MeOCl increased the activity of gamma-glutamyl transpeptidase. The activity of ceruloplasmin and the level of cholesterol in the blood plasma as well as the erythrocyte count in the blood were also similar in the control and experimental mice. The hematocrit value decreased after BrV and MeOCl administration. The relative weight of liver was higher in mice receiving both drugs in combination, than in control and in mice receiving BrV alone. The relative weight of spleen was significantly higher in animals receiving BrV alone, than in other groups.
Zaleska-Freljan
K I
KI
Department of Vertebrate Animal Physiology, University of Warsaw, Poland.
Wolewicz
J T
JT
D000818:Animals; D002570:Ceruloplasmin / Q000032:analysis*; D002709:Chlorfenvinphos / Q000031:analogs & derivatives* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood*; D004338:Drug Combinations; D004906:Erythrocyte Count; D006400:Hematocrit; D008297:Male; D008731:Methoxychlor / Q000494:pharmacology*; D051379:Mice; D009929:Organ Size; D005723:gamma-Glutamyltransferase / Q000097:blood*
D004338:Drug Combinations; C014369:bromfenvinphos; D002784:Cholesterol; D002570:Ceruloplasmin; D005723:gamma-Glutamyltransferase; D002709:Chlorfenvinphos; D008731:Methoxychlor