title: Increased ascitic fluid prorenin in the ovarian hyperstimulation syndrome.
abstract: Three patients developed severe ovarian hyperstimulation syndrome (OHS) as a complication of ovarian hyperstimulation for in vitro fertilization. These patients presented with ovarian enlargement, vascular volume depletion, pleural effusions, and exudative ascites. A unique feature of the ascites in OHS was the markedly elevated renin concentration, the majority of which was prorenin. We speculate the renin-angiotensin system (RAS) may play a pathophysiologic role in the localized capillary leak that develops in OHS.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis.
authors.forename: M E
authors.initials: ME
authors.lastname: Rosenberg
authors.forename: J K
authors.initials: JK
authors.lastname: Mckenzie
authors.forename: I M
authors.initials: IM
authors.lastname: Mckenzie
authors.forename: A
authors.initials: A
authors.lastname: Junaid
authors.forename: G E
authors.initials: GE
authors.lastname: Tagatz
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000201:enzymology*; D004792:Enzyme Precursors / Q000378:metabolism*; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000201:enzymology*; D012083:Renin / Q000378:metabolism*
chemical_list: D004792:Enzyme Precursors; D012083:Renin