ICAM-1 tissue overexpression associated with increased serum levels of its soluble form in Hodgkin's disease.
We investigated ICAM-1/CD54 tissue immunoreactivity and serum levels of its soluble form (sICAM-1) in patients with Hodgkin's disease (HD) at diagnosis. ICAM-1 was strongly expressed in involved tissues, and sICAM-1 serum levels were higher in HD (79 patients) than in controls (P < 0.01), and in patients with more advanced or more active disease (stages III + IV vI + II: P = 0.002; stage 'B' v 'A': P < 0.0001; 'bulky' disease v non-'bulky': P = 0.042). We suggest that tissue ICAM-1 overexpression leading to increase of circulating sICAM-1 may interfere with the lymphocyte adhesion machinery thus contributing to the well-known immune derangement of HD.
Pizzolo
G
G
Department of Haematology, Verona University School of Medicine, Italy.
Vinante
F
F
Nadali
G
G
Ricetti
M M
MM
Morosato
L
L
Marrocchella
R
R
Vincenzi
C
C
Semenzato
G
G
Chilosi
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000097:blood; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008297:Male; D008875:Middle Aged; D012995:Solubility
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1