[Sodium oxybutyrate normalizes the central nervous system functions in the progeny of rats subjected to hypobaric hypoxia during pregnancy].
Two-hour hypobaric hypoxia of rats on day 15 of their pregnancy led to a reduction in weight gain of pups within 20 days after birth, disturbed memory in active and passive paradigms, changed adaptive behavior in the extrapolatory water avoidance test, and impaired sleep in adult animals. Postnatal treatment with sodium hydroxybutyrate given in a dose of 50 mg/kg/day on days 8 to 20 of life normalized mnestic functions of the brain, the process of falling asleep, and physical development which had been impaired by intrauterine hypoxia.
Trofimov
S S
SS
Ostrovskaia
R U
RU
Smol'nikova
N M
NM
Kravchenko
E V
EV
Kutepova
O A
OA
Bondarenko
N A
NA
Nerobkova
L N
LN
Nemova
E P
EP
Voronina
T A
TA
D000818:Animals; D001273:Atmosphere Exposure Chambers; D002490:Central Nervous System / Q000187:drug effects* / Q000503:physiopathology; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008568:Memory / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D012978:Sodium Oxybate
Natriia oksibutirat mormalizuet funktsii tsentral'noĭ nervnoĭ sistemy u potomstva krys, podvergshikhsia gipobaricheskoĭ gipoksii vo vremia beremennosti.