The chemistry of desferrioxamine chelation for aluminum overload in renal dialysis patients.
The iron-chelating agent desferrioxamine now finds extensive use in the treatment and diagnosis of aluminum-related diseases in renal patients. We review the chemistry and pharmacokinetics of desferrioxamine in chelation therapy for patients on hemodialysis.
Day
J P
JP
Department of Chemistry, University of Manchester, England.
Ackrill
P
P
D000535:Aluminum / Q000506:poisoning*; D003676:Deferoxamine / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D006435:Renal Dialysis
D000535:Aluminum; D003676:Deferoxamine