title: [Infiltrating lobular carcinoma of the breast, alveolar variant, with stromal reactive osteoclast-like giant cells. Description of a case].
abstract: Authors report a case of alveolar variant of infiltrating lobular carcinoma of the breast with stromal osteoclast-like giant cells. Immunohistochemically the carcinoma cells were reactive for EMA and Cytokeratins; osteoclast-like giant cells (OCL-GC) were negative. OCL-GC and histiocytoid mononuclear cells with nuclei similar to those within the OCL-GC present in this case, were strongly immunoreactive with KP-1, a recently developed monoclonal antibody directed against cells of mononuclear phagocytic lineage in routinely processed tissue section and showed immunoreactivity to vimentin. These findings of our case provide evidence against a carcinoma cells derivation and support a monocytic/histiocytic origin for the OCL-GC.
authors.forename: D
authors.initials: D
authors.lastname: Reale
authors.forename: M
authors.initials: M
authors.lastname: Guarino
authors.forename: E
authors.initials: E
authors.lastname: Bianchini
authors.forename: C
authors.initials: C
authors.lastname: Crescini
authors.forename: M
authors.initials: M
authors.lastname: Pascale
authors.forename: M
authors.initials: M
authors.lastname: Mazzolari
authors.forename: G
authors.initials: G
authors.lastname: Micoli
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010010:Osteoclasts
vernacular_title: Carcinoma lobulare infiltrante della mammella, variante alveolare, con cellule giganti reatitive stromali osteoclasto-simili. Descrizione di un caso.