title: [Effects of synergism during combined antioxidant action of phosphatidylcholine with natural and synthetic quinones].
abstract: The combined action of ovarian phosphatidylcholine and phylloquinone (vitamin K1), menadione, artificial analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl-1,4-naphthoquinone (AK-40, AK-49) recommended as promising membrane protectors was studied. Synergic effects were detected in the antioxidant action of the quinones studied and phosphatidylcholine; AK-40 was the most effective in the presence of phosphatidylcholine. The synergic effect correlated with the concentrations of the antioxidants. Alterations in the synergism, which depended on phosphatidylcholine concentrations, were similar for all the inhibitors studied: the effect was proportionally increased with the elevation of phosphatidylcholine concentrations in the mixture up to 2.5 x 10(-3) M and then the synergic effect was unaltered during the further increase in phosphatidylcholine content.
authors.forename: N M
authors.initials: NM
authors.lastname: Storozhok
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Drulle
authors.forename: Ia Ia
authors.initials: IaIa
authors.lastname: Login
authors.forename: Ia Ia
authors.initials: IaIa
authors.lastname: Dregeris
authors.forename: E B
authors.initials: EB
authors.lastname: Burlakova
authors.forename: N G
authors.initials: NG
authors.lastname: Krapova
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D004357:Drug Synergism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011809:Quinones / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010713:Phosphatidylcholines; D011809:Quinones
vernacular_title: Effekty sinergizma pri sovmestnom antioksidantom deĭstvii fosfatidilkholina s prirodnymi i sinteticheskimi khinonami.