Alterations in Pseudomonas aeruginosa exoproducts by sub-MICs of some antibiotics.
Aminoglycoside antibiotics, most effective at the level of 1/4 of the MIC, suppressed all the tested activities of P. aeruginosa, except cytotoxicity. Proteinase activity was decreased to 60% (gentamicin) and 63% (streptomycin), permeability was reduced to 61% (gentamicin) and 73% (streptomycin), phospholipase C to 13% (gentamicin) and 51% (streptomycin) of the control values. Subinhibitory concentrations of beta-lactams inhibited only phospholipase C activity to 89% (ticarcillin) and 64% (cefotaxim) of the control values. These antibiotics did not suppress the cytotoxic activity and increased protease activity up to 155% (ticarcillin) and 192% (cefotaxim) as well as permeability up to 121% (ticarcillin) and 154% (cefotaxim) of the control values.
Hostacká
A
A
Research Institute of Preventive and Clinical Medicine, Bratislava.
Majtán
V
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D002463:Cell Membrane Permeability; D010450:Endopeptidases / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology; D013982:Ticarcillin / Q000494:pharmacology; D010738:Type C Phospholipases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010738:Type C Phospholipases; D010450:Endopeptidases; D013982:Ticarcillin; D002439:Cefotaxime; D013307:Streptomycin