Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers.
Acidic treatment of swinholide A (1), which was characterized as the major cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei, provided several isomeric macrolides having different size of the dilactone ring structure. From the structure-activity correlation viewpoint, the in vitro cytotoxicities and in vivo antitumor activities of these dimeric macrolides, together with two monomeric macrolides which were synthesized from 1, have been examined.
Kobayashi
M
M
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Kawazoe
K
K
Okamoto
T
T
Sasaki
T
T
Kitagawa
I
I
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D008297:Male; D008387:Marine Toxins / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003603:Cytotoxins; D008387:Marine Toxins; C068194:isoswinholide A; C086235:swinholide A