DNA polymorphisms of apolipoprotein B in the population of Taiwan.
Four apolipoprotein B (apoB) genetic polymorphisms, the AluI, XbaI, MspI and EcoRI restriction fragment length polymorphisms (RFLPs), were analyzed for 162 individuals in Taiwan by polymerase chain reaction. Allele frequency determination revealed that this population has 0.86 AluI- (A-), 0.99 XbaI- (X-), 1.0 MspI+ (M+), and 0.98 EcoRI+ (E+) alleles. Major genotypes were A-/A- (0.75), X-/X- (0.98), M+/M+ (1.0) and E+/E+ (0.96). There were 0.22 A-/A+, 0.02 X-/X+ and 0.04 E+/E- heterozygous genotypes and one minor homozygous A+/A+ (0.03) genotype. The XbaI allele frequency is similar to that found in the Japanese population (XbaI- 0.96), but is significantly different from that in Caucasians (XbaI- 0.31-0.54). Significant differences (p < 0.001) between the Taiwanese and Caucasians were also observed for the AluI, EcoRI and MspI RFLP alleles of the apoB gene. More heterozygous genotypes are observed in Caucasians than in the Taiwanese.
Wu
J H
JH
Department of Microbiology and Immunology (Molecular Genetic Laboratory 3), Chang-Gung Medical College, Tao-Yuan, Taiwan, R.O.C.
Wen
M S
MS
Lo
S K
SK
Wu
D
D
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000235:genetics*; D044466:Asian People; D001483:Base Sequence; D004247:DNA; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D013624:Taiwan; D044465:White People
D001055:Apolipoproteins B; D004247:DNA