Genomic imprinting: summary of an NICHD conference.
Compelling evidence for genomic imprinting as a pathogenetic mechanism in humans mandates re-evaluation of every genetic or multifactorial disease for parent-of-origin effects. In an expanding list of malformation syndromes, cancers, growth abnormalities, and chromosomal disorders, phenotypes may be determined by source rather than content of transmitted DNA. A multidisciplinary conference held on April 13-14, 1992, reviewed the substantial impact of genomic imprinting in mouse development and discussed in role in human pregnancy, childhood cancers, chromosomal translocations, X-inactivation, and several disorders associated with mental retardation. Topics for future research include the mechanism, timing, reversibility, and homology of the imprinting process.
Wilson
G N
GN
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
Hall
J G
JG
de la Cruz
F
F
D000818:Animals; D002869:Chromosome Aberrations; D004303:Dosage Compensation, Genetic; D005600:Fragile X Syndrome / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000235:genetics; D014481:United States