title: Toxicities associated with cryopreserved and thawed peripheral blood stem cell autografts in children with active cancer.
abstract: To evaluate the safety of cryopreserved and thawed peripheral blood stem cell (PBSC) autografts in children with active cancer, a toxicity assessment was made of 54 PBSC transfusions to 52 children (aged 1-16 years; median, 9 years). Patients were conditioned with high-dose chemotherapy without total body irradiation. The volume of PBSCs transfused varied from 46 to 500 mL (219.6 +/- 118.4 mL, mean +/- SD), with a mean of 0.91 g per kg of dimethyl sulfoxide. Insignificant and transient toxicities included hemoglobinuria in 40 patients (74%), headache in 38 (70%), nausea in 37 (69%), and vomiting in 25 patients (46%). Significant shock developed in 8 patients (15%), but they recovered quickly, whether they had supportive therapy or not. Vomiting and hyperbilirubinemia were the only toxicities that showed a correlation with the amount of PBSCs transfused. The data suggest that transient toxicity associated with PBSC autografts is rather common in children, and close observation of patients for possible serious morbidity is required.
authors.affiliation: Department of Pediatrics, University Hospital of Tokushima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Takaue
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Suzue
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Hirao
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D000293:Adolescent; D001793:Blood Preservation; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery; D008297:Male; D009447:Neuroblastoma / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D012175:Retinoblastoma / Q000601:surgery; D014182:Transplantation, Autologous / Q000009:adverse effects*