title: Immunochemical localization of integrin subunits in the human placenta.
abstract: Localization of integrins in the human placenta was examined in comparison with those of fibronectin and laminin. In the early chorionic villi, the alpha 5 and beta 1 subunits were localized on the basal surface of villous cytotrophoblastic cells, while the alpha 6 and beta 4 subunits were distributed around the entire surface of the cytotrophoblastic cells, suggesting that these cells attach to fibronectin rather than laminin on the epithelial basement membrane. In the term placenta, the alpha 5 subunit was not detected on the epithelial cells, but the beta 6 and beta 4 subunits were detected on the basal surface of syncytiotrophoblastic cells, suggesting that these cells make use of alpha 6 beta 4 integrin to attach to the trophoblastic basement membrane. These results suggest that cells utilize the specific receptor for their attachment in correspondence to the extracellular matrix component to which they attach.
authors.affiliation: Department of Food and Nutritional Sciences, University of Shizuoka.
authors.forename: M
authors.initials: M
authors.lastname: Isemura
authors.forename: T
authors.initials: T
authors.lastname: Kazama
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
mesh_terms: D002824:Chorionic Villi / Q000737:chemistry*; D005260:Female; D005353:Fibronectins / Q000032:analysis*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D016023:Integrins / Q000032:analysis*; D007797:Laminin / Q000032:analysis*; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy
chemical_list: D005353:Fibronectins; D016023:Integrins; D007797:Laminin