So, what about the molecular clock hypothesis?
Recent studies have provided strong evidence for significant variation in rates of nucleotide substitution among evolutionary lineages. They have also provided evidence for germ-cell division as a major source of mutation (i.e. the generation-time effect hypothesis). Moreover, they have suggested the importance of differences in metabolic rate as a cause of rate variation.
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Center for Demographic and Population Genetics, University of Texas, Houston 77225.
D000818:Animals; D005075:Biological Evolution; D005260:Female; D016678:Genome; D006801:Humans; D008297:Male; D008660:Metabolism; D008954:Models, Biological; D013997:Time Factors