Immunohistochemical analysis of gastrointestinal carcinoids.
Clinicopathological and immunohistochemical analyses were performed on ten samples of gastrointestinal carcinoids resected in Ishikawa Prefectural Central Hospital. All samples showed positive reaction to chromogranin A. Serotonin was detected in 8 samples, somatostatin in 4 samples, gastrin in 2 samples. Glucagon/Glicentin in 1 sample, and PYY production in 2 samples. CEA production was detected in 8 samples, and microvascular invasion was observed in 6 of these 8 patients. The PCNA/cyclin labeling index (L.I.) of the cases with metastases was significantly higher than those without metastases. In conclusion, the expression of CEA and the PCNA/cyclin L.I. may be useful markers of the malignant potential of carcinoid tumors.
Hayashi
H
H
Department of Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Nakagawa
M
M
Kitagawa
S
S
Yamada
T
T
Ishida
K
K
Kurumaya
H
H
D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002276:Carcinoid Tumor / Q000737:chemistry* / Q000453:epidemiology / Q000556:secondary; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry; D005770:Gastrointestinal Neoplasms / Q000737:chemistry* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen