title: The pharmacological reactivity of an isolated circular smooth muscle strip of the rabbit common bile duct.
abstract: An in vitro isolated spiral strip of rabbit common bile duct was prepared and tested for its pharmacological reactivity. It was found to be a suitable preparation with a long lasting and stable sensitivity when exposed to various drugs. The pharmacological reactivity proved to vary along the common bile duct; the different portions (sphincteric, median and hepatic) displayed different activities to the various agonists and antagonists. The following receptors were identified in different sections: alpha and beta-adrenergic, muscarinic cholinergic, bradykinin, H1 and prostaglandin F2 alpha. Only the sphinteric portion exhibited rhythmic peristalsis; the other portions produced merely small, irregular spontaneous contractions.
authors.affiliation: Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged.
authors.forename: E
authors.initials: E
authors.lastname: Minker
authors.forename: T
authors.initials: T
authors.lastname: Várkonyi
authors.forename: E
authors.initials: E
authors.lastname: Tamáskovits
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D003135:Common Bile Duct / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D010277:Parasympathomimetics / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology; D011817:Rabbits; D009803:Sphincter of Oddi / Q000187:drug effects / Q000502:physiology*
chemical_list: D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D010277:Parasympathomimetics; D011453:Prostaglandins; D001920:Bradykinin