Pharmacokinetics of succinylcholine in man.
The pharmacokinetics of succinylcholine (SCh) 1 or 2 mg/kg was studied in 14 anesthetized patients. Arterial blood concentrations of SCh were measured using a high-performance liquid chromatographic assay. The arterial concentration vs. time data were analyzed by log-linear regression and fitted to an one-compartment model. The pharmacokinetic parameters were (SCh 1, n = 8 and 2 mg/kg, n = 6): apparent volume of distribution (16.4 +/- 14.7 and 5.6 +/- 6.8 ml/kg, mean +/- S.D.), total body clearance (40.5 +/- 38.7 and 15.0 +/- 14.8 liter/min), area under the plasma concentration-time curve (124.3 +/- 163.2 and 695.3 +/- 1008.9 min.micrograms/ml), and elimination half-life (16.6 +/- 4.8 and 11.7 +/- 4.5 sec). The rapid disappearance of SCh from the blood may be due to diffusion out of the blood vessel.
Hoshi
K
K
Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Japan.
Hashimoto
Y
Y
Matsukawa
S
S
D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013390:Succinylcholine / Q000097:blood / Q000493:pharmacokinetics*
D013390:Succinylcholine