[Diminished experimental alimentary atherogenesis under the influence of polymers that decrease the hydrodynamic resistance of the blood].
The experiments on adult rabbits have demonstrated that high-cholesterol diet given to the animals for 3 months causes a severe hypercholesterolemia and disseminated aortic lesion due to the formation of numerous fatty streaks and plaques of atherosclerotic genesis. The simultaneous intravenous injection of a special linear high molecular-weight polymer solution, which reduces hydrodynamic resistance once a week leads to a significantly less atherogenesis in the same hypercholesterolemia. The highest effect was observed in the descending portions of the aorta and just after its bifurcation, i.e. in the areas of the least unsteady blood flow.
Gannushkina
I V
IV
Antelava
A L
AL
Baranchikova
M V
MV
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology; D001769:Blood / Q000187:drug effects*; D001790:Blood Physiological Phenomena; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004036:Diet, Atherogenic; D006400:Hematocrit; D009994:Osmolar Concentration; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D002791:Cholesterol, Dietary; D011108:Polymers; D011092:Polyethylene Glycols; D002784:Cholesterol
Umen'shenie éksperimental'nogo alimentanogo aterogeneza pod vliianiem polimerov, snizhaiushchikh gidrodinamicheskoe soprotivlenie krovi.