Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro.
The effect of ethanol on hepatic lipoprotein secretion is not fully understood. This study shows that exposure of HepG2 cells to ethanol significantly increases intracellular apolipoprotein B, apo B mRNA and secreted apolipoprotein B. No other agent has been shown to produce such an increase in apolipoprotein B synthesis or apolipoprotein B mRNA levels.
Wang
T W
TW
Department of Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK.
Byrne
C D
CD
Hales
C N
CN
D001055:Apolipoproteins B / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D018197:Hepatoblastoma; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008113:Liver Neoplasms; D012333:RNA, Messenger / Q000378:metabolism; D014407:Tumor Cells, Cultured
D001055:Apolipoproteins B; D012333:RNA, Messenger; D000431:Ethanol