[The protective action of sodium hypochlorite on the morphology and transcription of the central neurons in rats with acute nembutal poisoning].
NaClO effect on rat central neuron morphology and transcription after injection of high doses (500 mg/kg b.w.) of nembutal (NB) was studied. Cortical pyramids, Purkinje, basket and granule cells were examined. NaClO (3 mg/kg b.w) was injected 45 min after NB injection, and 45 min later animals were sacrificed. Intact rats and rats injected NB or NaClO alone were controls. NB treatment resulted in toxic-hypoxic injury of cerebral and cerebellar neurons. Transcription in all types of neurons was lower than in control cells. NaClO injected alone had virtually no effect on neuronal morphology while transcription in the middle pyramids and Purkinje cells was activated. NaClO injected after NB normalized morphology and transcription in all neuronal populations under study. In cortical pyramids transcription was even higher than in control group.
Sergienko
V I
VI
Grigor'eva
A V
AV
Artemkina
I V
IV
Bul'chuk
O V
OV
Lopukhin
Iu M
IuM
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010424:Pentobarbital / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012973:Sodium Hypochlorite / Q000627:therapeutic use*; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects* / Q000502:physiology
D012973:Sodium Hypochlorite; D010424:Pentobarbital
Protektornoe deĭstvie gipokhlorita natriia na morfologiiu i transkriptsiiu tsentral'nykh neĭronov krysy pri ostrom otravlenii nembutalom.