title: [The detection and significance of plasma atrial natriuretic peptide in advanced schistosomiasis patients].
abstract: The plasma levels of atrial natriuretic peptide (ANP) were determined with radioimmunoassay in 23 cases of advanced schistosomiasis, 16 cases of chronic schistosomiasis and 16 normal subjects. The results were: the plasma ANP level in advanced schistosomiasis (286.6 +/- 13.0 ng/L) was significantly higher than that in of chronic schistosomiasis (196.7 +/- 17.3 ng/L) and normal controls (157.2 +/- 16.0 ng/L) (P < 0.01 respectively). Among advanced schistosomiasis, the plasma ANP level in 12 cases with ascites (256.5 +/- 16.8 ng/L) was significantly lower than that in 11 cases with splenomegaly but without ascites (320.5 +/- 20.0 ng/L) (P < 0.05). There was no significant difference between the levels in chronic schistosomiasis and normal control (P > 0.05), the results suggested that ANP played a role in maintaining homeostasis of sodium and fluid in advanced schistosomiasis.
authors.affiliation: Department of Infections Diseases, First Affiliated Hospital, Hubei Medical University, Wuhan.
authors.forename: Y A
authors.initials: YA
authors.lastname: Jiang
authors.forename: S N
authors.initials: SN
authors.lastname: Yan
authors.forename: M Y
authors.initials: MY
authors.lastname: Guan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001201:Ascites / Q000097:blood / Q000209:etiology; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012554:Schistosomiasis japonica / Q000097:blood* / Q000150:complications; D013163:Splenomegaly / Q000097:blood / Q000209:etiology
chemical_list: D009320:Atrial Natriuretic Factor