title: Field efficacy of injectable moxidectin in cattle naturally infested with Chorioptes bovis and Sarcoptes scabiei.
abstract: Field efficacy of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Chorioptes bovis and Sarcoptes scabiei. Eight animals were allocated to two groups of four animals each, based on parasitological and clinical status. Animals of the treated group received one subcutaneous injection of injectable moxidectin at 0.2 mg kg-1 body weight on Day 0. Individuals of the control group received emergency treatment of a single injection of moxidectin at 0.2 mg kg-1 body weight on Day 28. Efficacy was assessed by (a) taking skin samples from each animal on Days 0, 7, 14, 21, 28, 42 and 56 and observing the numbers of viable mite stages and species and (b) clinical examination of animals on Days 7, 14, 21, 28, 42 and 56 with the percentage of affected body surface calculated for each animal on Days 0, 28 and 56. On the basis of the geometric means from treated and control animals, the percentage reductions in the total numbers of living C. bovis mites on Days 7, 14, 21 and 28 were 69, 87, more than 99 and 98, respectively. However, at the end of the trial, only two animals were negative for C. bovis. The percentage reductions in the total numbers of S. scabiei on Days 7, 14, 21 and 28 were 93, 100, 100 and 100, respectively. Clinical indices of the treated animals showed a sharp decrease in the affected body surface area from a mean of 43.6% on Day 0 to 0.9% and 0% on Days 28 and 56, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Laboratory of Parasitology and Pathology of Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Losson
authors.forename: J F
authors.initials: JF
authors.lastname: Lonneux
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D008925:Mites / Q000254:growth & development; D012520:Sarcoptes scabiei / Q000254:growth & development; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D012867:Skin / Q000469:parasitology
chemical_list: D000900:Anti-Bacterial Agents; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin