A genetic linkage map of chromosome 21: a look at meiotic phenomena.
We have developed a genetic linkage map of chromosome 21 using 17 microsatellite marker polymorphisms. The markers span virtually the entire length of 21q, and define a sex-equal map of 56 cM. Extensive error checking has been used to provide an accurate map. All recombination events have been identified, allowing us to place within a small interval any new markers by genotyping only a few critical individuals. The resulting segregation data has been examined for several meiotic phenomena, including sex differences in recombination, age differences in recombination, interference, and segregation distortion.
Haines
J L
JL
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129.
Guillemette
W
W
Rosen
D
D
Brown
R
R
Donaldson
D
D
Patterson
D
D
D000544:Alzheimer Disease / Q000235:genetics; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D008540:Meiosis