title: Ploidy and survival in resectable pancreatic cancers. A retrospective study over 9 years.
abstract: OBJECTIVE
  To evaluate the association between ploidy and operability and prognosis in pancreatic cancer.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Ullevaal Hospital and the National Hospital of Norway, Oslo.
  
  
  METHODS
  148 patients with histologically verified pancreatic cancer diagnosed between 1980 and 1988.
  
  
  METHODS
  29 patients had radical resections (18 Whipple procedures and 11 total pancreatectomies). Archival tissue was investigated in the blocks from these tumours, and from five patients who had only a biopsy taken, by DNA flow cytometry.
  
  
  RESULTS
  26/29 tumours excised radically had diploid DNA stemlines. Two of the three aneuploid stemlines were hyperdiploid, and the third was almost triploid. Among the five inoperable tumours, two were aneuploid and three diploid. The patients who underwent radical operations lived a median of 11.5 months (range 0-82), compared with a median of 4 months (range 0-58) for those whose tumours were inoperable. Six of the 29 patients were still alive without signs of recurrent disease 51.5 months (range 41-82) after operation. All but one of these tumours had diploid DNA stemlines, and synthesis (S) phase fractions below the median value for the whole group.
  
  
  CONCLUSIONS
  DNA ploidy and S phase fraction are prognostic factors in pancreatic cancer.
authors.affiliation: Department of Surgery, Ullevaal Hospital, Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Schlichting
authors.forename: O P
authors.initials: OP
authors.lastname: Clausen
authors.forename: A S
authors.initials: AS
authors.lastname: Hanssen
authors.forename: T A
authors.initials: TA
authors.lastname: Buanes
mesh_terms: D000368:Aged; D000782:Aneuploidy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics* / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000601:surgery; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies; D016196:S Phase; D015996:Survival Rate
chemical_list: D004273:DNA, Neoplasm