title: [Combined concomitant chemotherapy and radiotherapy with or without surgery in the treatment of non-metastatic squamous carcinoma of the esophagus].
abstract: Between June 1986 and October 1992 two prospective non-randomized and consecutive therapeutic schemes with a curative intent of non-metastatic squamous cell carcinoma of the esophagus were developed. The first scheme consisted of concomitant administration of chemotherapy (cisplatin and 5-fluorouracil, 2 cycles) and radiotherapy (30 Gys) after surgery (esophagectomy) (14 evaluable patients). Without surgery, a higher dose of chemotherapy (4 cycles) and radiotherapy (55 Gys) was given on the second scheme (12 evaluable patients). Complete histological response was 42.6% for the first scheme and 50% for the second one. Toxicity was moderate in both schemes. Palliation was important in the second scheme. Actuarial survival was 28% at 1 year for the first scheme and 71% for the second one. Operative mortality was 27%. Concomitant chemoradiotherapy might be a therapeutic choice for locoregional control of squamous esophageal carcinoma.
authors.affiliation: Servicio de Oncología Médica, Hospital Clínico Universitario, Zaragoza.
authors.forename: M D
authors.initials: MD
authors.lastname: Isla
authors.forename: A
authors.initials: A
authors.lastname: Sáenz
authors.forename: A
authors.initials: A
authors.lastname: Tres
authors.forename: P
authors.initials: P
authors.lastname: Escudero
authors.forename: C
authors.initials: C
authors.lastname: Jara
authors.forename: R
authors.initials: R
authors.lastname: Escó
authors.forename: M
authors.initials: M
authors.lastname: González
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000401:mortality / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016019:Survival Analysis
vernacular_title: Combinación de quimioterapia y radioterapia concomitantes con o sin cirugía en el tratamiento del carcinoma escamoso de esófago no metastásico.