Transplantation of autologous peripheral blood stem cells mobilized using GM-CSF for acute leukemia with myelofibrosis.
A patient with acute mixed lineage leukemia had marked marrow fibrosis at presentation. The fibrosis persisted despite achievement of complete remission. Because the marrow was inaspirable, granulocyte-monocyte colony-stimulating factor (GM-CSF) was used to mobilize stem cells into the peripheral blood which were used for autologous transplantation. Myeloid engraftment was rapid. The extent of the fibrosis decreased after transplantation. GM-CSF-mobilized peripheral blood stem cells may be used for autologous transplantation in patients with fibrotic marrows who are not candidates for allografting.
Mehta
J
J
Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey, U.K.
Powles
R L
RL
Shepherd
V
V
Dainton
M
M
Treleaven
J
J
D000208:Acute Disease; D000328:Adult; D002469:Cell Separation; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000628:therapy*; D055728:Primary Myelofibrosis / Q000097:blood* / Q000150:complications / Q000628:therapy; D014182:Transplantation, Autologous
D016178:Granulocyte-Macrophage Colony-Stimulating Factor