[The possible participation of gap junctions in the realization of the effects of stimulators of secretory processes in the hypophysis].
Sodium butyrate and octanol did not change the basal rate of GH secretion. However, octanol completely and partially suppressed GH release stimulated by thyroliberin and DbcAMP, respectively. Octanol did not influence GH secretion induced by DbcGMP. Besides, octanol did not change significantly basal prolactin release, but this agent blocked secretogenic action of on lactotrophs. The results show the important role of cell-to-cell communication mediated by gap junctions in stimulatory action of thyroliberin and cAMP analogue on GH release from neonatal pituitary cells, as well as in secretogenic action of thyroliberin on lactotrophs.
Fedotov
V P
VP
Gudoshnikov
V I
VI
Baranova
I N
IN
D000818:Animals; D000831:Animals, Newborn; D003994:Bucladesine / Q000494:pharmacology; D002087:Butyrates / Q000494:pharmacology; D020148:Butyric Acid; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D005260:Female; D017629:Gap Junctions / Q000187:drug effects* / Q000378:metabolism; D013006:Growth Hormone / Q000187:drug effects / Q000378:metabolism; D008297:Male; D000442:Octanols / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D002087:Butyrates; D000442:Octanols; D020148:Butyric Acid; D003995:Dibutyryl Cyclic GMP; D013973:Thyrotropin-Releasing Hormone; D003994:Bucladesine; D013006:Growth Hormone
Vozmozhnoe uchastie shchelevykh kontaktov v realizatsii éffektov stimuliatorov sekretornykh protsessov v gipofize.