Effects of dietary clenbuterol on net flux across the portal-drained viscera, liver and hindquarters of steers (Bos taurus).
1. Addition of the beta-adrenergic agonist clenbuterol to the diet of steers increased blood flow in portal-drained viscera, liver and tissues of the hindquarters. 2. Uptake of oxygen increased with clenbuterol feeding in hindquarters but not portal-drained viscera or liver. 3. On day 1 of clenbuterol feeding, the principal source of circulating L-lactate switched from portal-drained viscera to hindquarters. 4. Both net release of alpha-amino nitrogen by the portal-drained viscera and net uptake by the hindquarters decreased on day 1 of clenbuterol feeding. Over time of clenbuterol feeding, both release of alpha-amino nitrogen by the portal-drained viscera and uptake by the hindquarters increased to equal or greater than pretreatment values, respectively.
Eisemann
J H
JH
USDA-ARS, Roman L. Hruska U.S. Meat Animal Research Center, Clay Center, NE 68933.
Huntington
G B
GB
D000818:Animals; D002976:Clenbuterol / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D004734:Energy Metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008102:Liver Circulation; D008297:Male; D009584:Nitrogen / Q000097:blood; D010101:Oxygen Consumption; D012039:Regional Blood Flow / Q000187:drug effects; D014781:Viscera / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism
D007773:Lactates; D019344:Lactic Acid; D009584:Nitrogen; D002976:Clenbuterol