title: The influence of middle ear pressure changes on the primary vestibular neurons in guinea pigs.
abstract: The responses of primary vestibular neurons and perilymphatic pressure changes to middle ear pressure stimuli in guinea pigs were investigated in order to clarify the direct effects of pressure stimulus on the vestibular apparatus. The vestibular response was related to the amount of middle ear pressure change applied at a rate of +/- 100 mmH2O/s. The neural response rates of vestibular units to positive pressure in the middle ear were significantly larger than those to negative pressure. The time course pattern of the perilymphatic pressure change resembled that of the response of the vestibular units, indicating that the vestibular response is elicited by middle ear pressure via the pressure transmitted in the inner ear.
authors.affiliation: Department of Otolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kitahara
authors.forename: H
authors.initials: H
authors.lastname: Kitano
mesh_terms: D000818:Animals; D004432:Ear, Middle / Q000502:physiology*; D005071:Evoked Potentials; D006168:Guinea Pigs; D009474:Neurons / Q000502:physiology*; D010498:Perilymph / Q000502:physiology*; D011312:Pressure; D012444:Saccule and Utricle / Q000294:innervation; D012665:Semicircular Canals / Q000294:innervation; D013997:Time Factors; D014725:Vestibular Nerve / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000294:innervation*