Selective immunosuppression of class II-restricted T cells by MHC class II-binding peptides.
Administration of major histocompatibility complex (MHC) class II-binding synthetic peptides can induce selective immunosuppression via different mechanisms of action. In this review four different ways to induce selective immunosuppression by peptide administration will be examined: MHC blockade, T cell receptor (TCR) antagonism, induction of peripheral tolerance, and activation of regulatory cells. These approaches to selective immunosuppression target three types of cells: antigen-presenting cells, antigen-specific T cells, and regulatory T cells. Understanding these forms of immunosuppression will provide new insights in basic immunology and may offer strategies for selective immunointervention in autoimmune diseases, allograft rejection, and allergy.
Guéry
J C
JC
Roche Milano Ricerche, Italy.
Adorini
L
L
D000818:Animals; D001667:Binding, Competitive; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D010455:Peptides / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000037:antagonists & inhibitors*
D000949:Histocompatibility Antigens Class II; D010455:Peptides; D011948:Receptors, Antigen, T-Cell