title: The effect of chronic ingestion of ethanol on modulation of granulomatous inflammation in experimental schistosomiasis in mice.
abstract: We studied the role of ethanol on the modulation of liver granulomata around Schistosoma mansoni eggs in mice. Albino mice, receiving 7% ethanol as the sole drinking liquid, at 60 and 90 days post-infection, presented smaller granulomata than controls did, when sacrificed at 120 days post-infection. No differences in diameters could be observed, when ethanol was given 4 months before up to 120 days after infection. The results suggested that modulation of schistosome granulomata by ethanol ingestion varies with time and duration of drug consumption.
authors.affiliation: Departamento de Anatomia Patológica e Medicina Legal, Faculdade de Medicina da UFMG, Belo Horizonte.
authors.forename: L P
authors.initials: LP
authors.lastname: Castro
authors.forename: E A
authors.initials: EA
authors.lastname: Bambirra
authors.forename: P M
authors.initials: PM
authors.lastname: Coelho
authors.forename: M E
authors.initials: ME
authors.lastname: Silva
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006099:Granuloma / Q000469:parasitology / Q000473:pathology*; D008109:Liver Diseases, Parasitic / Q000473:pathology*; D051379:Mice; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000473:pathology*
chemical_list: D000431:Ethanol