Translocation (8;17)(p21;q21), a possible variant of t(15;17), in acute promyelocytic leukemia.
We report a 64-year old man with typical features of acute promyelocytic leukemia (APL) [M3, French-American-British (FAB) classification] in whom a variant, t(8;17)(p21;q21), was detected. This is the second case of the same variant translocation to be reported. The breakpoint on 17q was similar to those described in cases with a standard translocation 15;17. Consequently, this chromosome break or rearrangement at band 17q21, rather than the recipient site of translocation of the deleted material, appears to be of crucial importance in the genesis of APL.
Miura
I
I
Third Department of Internal Medicine, Akita University School of Medicine, Japan.
Nishinari
T
T
Hashimoto
K
K
Nimura
T
T
Miura
S
S
Miura
A B
AB
D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002898:Chromosomes, Human, Pair 8; D014644:Genetic Variation; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic