[The development of a new experimental model of pneumocystosis].
The corticosteroid tricort-40 (triamcinolone acetonide) was found to induce the reactivation of endogenous pneumocystic injection caused by P. carinii in Wistar rats given 5-9 infections subcutaneously in median doses of 0.5-4.0 mg/kg at 6-22 days intervals each. Manifest P. carinii infection in the animals was characterized by early detection of its agent (starting from week 2 of immunosuppression), a progression of the infection and its transition to the generalized stage. The combined use of tricort-40 and infection of the animals with Leishmania infantum as an immunosuppressive cofactor ensured an increase in reproducibility of a manifest pneumocystosis model and its more rapid transition to the generalized stage. The experimental model of mixed infection of two AIDS-associated parasite infections--generalized pneumocystosis and visceral leishmaniasis--was first reproduced in inbred rats, which may be suitable for simultaneous screening of new antipneumocystic and antileishmanial drugs.
Lavdovskaia
M V
MV
Kovalenko
F P
FP
Lysenko
A Ia
AIa
Strelkova
M V
MV
Chernov
Iu V
IuV
D000818:Animals; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology; D018314:Leishmania infantum / Q000472:pathogenicity; D008297:Male; D011010:Pneumocystis / Q000472:pathogenicity; D016720:Pneumocystis Infections / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide
Razrabotka novoĭ éksperimental'noĭ modeli pnevmotsistoza.