title: Aortic dissection in the thrombolytic era: early recognition and optimal management is a prerequisite for increased survival.
abstract: Based on two case reports, problems of diagnosis and treatment of aortic dissection are discussed. Thrombolytic treatment given to patients with aortic dissection presenting symptoms mimicking acute MI seems to have a fatal outcome. Indications, as well as contra-indications, for thrombolytic therapy are therefore of great importance, when this treatment is given to patients suspected of having acute myocardial infarction, especially where diagnosis is uncertain or as prehospital treatment. In patients with chest pain symptoms without typical history and electrocardiographic changes the diagnosis should be reconsidered within a few hours and, if possible, together with echocardiographic findings. In doing so patients with coronary heart disease will get all the benefits of thrombolytic treatment. Furthermore the importance of quick accurate diagnosis, especially in type A aortic dissection is pointed out, as emergency surgical intervention can be lifesaving. A more aggressive medical and surgical approach has contributed to the improved survival among patients with aortic dissections.
authors.affiliation: Department of Cardiology, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Melchior
authors.forename: D
authors.initials: D
authors.lastname: Hallam
authors.forename: B E
authors.initials: BE
authors.lastname: Johansen
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000175:diagnosis* / Q000401:mortality; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000401:mortality; D000075202:Contraindications; D003937:Diagnosis, Differential; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy*; D015912:Thrombolytic Therapy