title: Group sequential testing in clinical trials with multivariate observations: a review.
abstract: Most group sequential testing procedures assume that each patient has only one response. Thus interim test statistics have independent increments. In many clinical trials, however, a response variable is measured at each follow-up visit. In this article, I review some recently developed group sequential methods for repeated measures and for other types of multivariate responses. Six parametric methods and three non-parametric methods are included. My review focuses on the comparison of the assumptions made and the applications of each of these methods.
authors.affiliation: Department of Preventive Medicine, University of Southern California, Arcadia 91066-6012.
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D016014:Linear Models; D015999:Multivariate Analysis; D016019:Survival Analysis