title: Visualization of damaged brain tissue after ischemic stroke with cobalt-55 positron emission tomography.
abstract: In animal experiments, the radionuclide 55Co2+ has been shown to accumulate in degenerating cerebral tissue similar to Ca2+.
  
  
  METHODS
  The potential role of 55Co2+ for in vivo brain PET imaging was investigated in four patients after ischemic stroke.
  
  
  RESULTS
  PET showed uptake of 55Co2+ in damaged brain tissue irrespective of blood-brain barrier integrity, as affirmed by CT and MRI.
  
  
  CONCLUSIONS
  Our preliminary results indicate that 55CoCl2 may prove to be a useful and relatively inexpensive PET radiopharmaceutical for visualization of degenerative processes in brain tissue.
authors.affiliation: Department of Biological Psychiatry, Neurology, PET-Research Center, University Hospital Groningen, The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: Jansen
authors.forename: J
authors.initials: J
authors.lastname: Pruim
authors.forename: A M
authors.initials: AM
authors.lastname: vd Vliet
authors.forename: A M
authors.initials: AM
authors.lastname: Paans
authors.forename: J M
authors.initials: JM
authors.lastname: Hew
authors.forename: E J
authors.initials: EJ
authors.lastname: Franssen
authors.forename: B M
authors.initials: BM
authors.lastname: de Jong
authors.forename: J G
authors.initials: JG
authors.lastname: Kosterink
authors.forename: R
authors.initials: R
authors.lastname: Haaxma
authors.forename: J
authors.initials: J
authors.lastname: Korf
mesh_terms: D000368:Aged; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003037:Cobalt Radioisotopes; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D003037:Cobalt Radioisotopes