Immunohistochemical observations of macrophages and perisinusoidal cells in carbon tetrachloride-induced rat liver injury.
In rat liver injured by carbon tetrachloride, ED-1-positive monocytes and resident macrophages significantly increased in number in damaged perivenular zones on days 2 and 4 after single or double dosing, peaking on day 2 and being two-fold more after the 2nd dosing. ED-2-positive resident macrophages significantly increased in number only on day 4 after the single dosing and on days 2, 4 and 6 after the 2nd dosing with a peak on day 2. A significant increase in number of muscle actin-positive perisinusoidal cells was seen on day 4 and on days 2 and 4 after the 1st and 2nd dosings, respectively, reaching a peak on day 4 and being more remarkable after the 2nd dosing.
Yamate
J
J
Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
Tatsumi
M
M
Nakatsuji
S
S
Kuwamura
M
M
Kotani
T
T
Sakuma
S
S
D000199:Actins / Q000032:analysis; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006056:Golgi Apparatus / Q000473:pathology / Q000648:ultrastructure; D007150:Immunohistochemistry / Q000379:methods; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008264:Macrophages / Q000473:pathology*; D008854:Microscopy, Electron; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D000199:Actins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase