Gravidin: an endogenous inhibitor of phospholipase A2.
Gravidin is a recently discovered protein inhibitor of phospholipase A2 and therefore prostaglandin synthesis. Transformed or rapidly growing cells are unaffected by gravidin, but in slow-growing cells arachidonate release is inhibited. Gravidin may play a physiological role in pregnancy maintenance. This review summarizes our current knowledge of the properties and activity of gravidin.
Wilson
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Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, University of Dundee, Scotland.
D000818:Animals; D006801:Humans; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011257:Pregnancy Proteins / Q000096:biosynthesis / Q000494:pharmacology* / Q000502:physiology; D011453:Prostaglandins / Q000096:biosynthesis
D011257:Pregnancy Proteins; D011453:Prostaglandins; C058795:gravidin; D010741:Phospholipases A; D054467:Phospholipases A2