[Brain gangliosides and memory formation].
It is generally accepted that the process of molecular facilitation (= Bahnung) of neuronal circuits by means of stabilization of synaptic contacts represents the structural basis for memory formation. On the basis of physiological, electron microscopic, biochemical, and physicochemical data, a concept is presented speaking in favor of the idea that interactions between brain gangliosides (= amphiphilic sialic acid-containing glycosphingolipids with peculiar physicochemical properties), calcium, and functional membraneous proteins (ion channels, ion pumps, receptors, kinases) play a crucial modulatory role in the transmission and storage of information.
Rahmann
H
H
Zoologisches Institut der Universität, Stuttgart, Hohenheim.
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D002240:Carbohydrate Sequence; D005732:Gangliosides / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D008969:Molecular Sequence Data; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D005732:Gangliosides
Hirnganglioside und Gedächtnisbildung.