[The stress-protective effect of a new derivative of n-3-polyunsaturated fatty acids].
It has been established that prophylactic oral administration of the new derivative of n-3 polyunsaturated fatty acids--P-55 in a daily dose of 0.2 g/kg during 30 days prevents some morphological and physiological manifestations of the chronic stress-syndrome in white rats. There were normalized body and some internal organs weights, content and distribution of ascorbic acid in the adrenal tissue; decreased intensity of gastric ulcerogenesis. The behaviour of animals became more quiet. It is concluded that the preparation P-55 has a stress-protective effect during its prophylactic administration.
Kresiun
V I
VI
Iurlov
V M
VM
Tishchenko
A V
AV
Oleĭnik
N N
NN
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006651:Histocytochemistry; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation; D013276:Stomach Ulcer / Q000378:metabolism / Q000517:prevention & control; D013312:Stress, Physiological / Q000378:metabolism / Q000517:prevention & control*
D015525:Fatty Acids, Omega-3; C086068:P-55 omega-3 fatty acid; D001205:Ascorbic Acid
Stress-protektornyĭ éffekt novogo proizvodnogo n-3-polinenasyshchennykh zhirnykh kislot.