title: Perfluoropropane 12% versus 20%. Effect on intraocular pressure and gas tamponade after pars plana vitrectomy.
abstract: A randomized prospective study was performed on 30 nonglaucomatous eyes undergoing pars plana vitrectomy and intraoperative fluid-gas exchange, comparing the effect of two perfluoropropane gas concentrations (12% and 20%) on postoperative intraocular pressure, early postoperative bubble size, and intravitreal longevity. No significant differences in mean intraocular bubble size at 36 to 48 hours and mean peak and final follow-up intraocular pressure were found between the 12% group (n = 15) and the 20% group (n = 15, unpaired T-test). Intravitreal longevity was significantly greater for the 20% concentration (mean +/- standard deviation = 8.4 +/- 1.8 weeks) compared with the 12% concentration (mean +/- standard deviation = 6.7 +/- 1.6 weeks). In nonglaucomatous eyes under careful observation and appropriate antiglaucoma therapy, the choice between a 12% or 20% concentration of perfluoropropane gas determined primarily longevity of gas tamponade rather than postoperative pressure or early bubble size.
authors.affiliation: Department of Ophthalmology, Medical College of Wisconsin, Milwaukee.
authors.forename: D P
authors.initials: DP
authors.lastname: Han
authors.forename: G W
authors.initials: GW
authors.lastname: Abrams
authors.forename: S R
authors.initials: SR
authors.lastname: Bennett
authors.forename: D F
authors.initials: DF
authors.lastname: Williams
mesh_terms: D004311:Double-Blind Method; D005260:Female; D005466:Fluorocarbons; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000503:physiopathology* / Q000601:surgery*; D014065:Tonometry, Ocular; D014821:Vitrectomy / Q000379:methods*
chemical_list: D005466:Fluorocarbons; C042852:perflutren