title: Calcium kinetics in lactating women with low and high calcium intakes.
abstract: Absorption of calcium and its mobilization from bone during lactation are important for delivery of calcium to breast-feeding infants; whether calcium intake offsets bone resorption is not known. We hypothesized that calcium absorption is increased in lactation and greater in women on low calcium diets, resulting in similar rates of bone resorption and accretion. Calcium absorption and kinetic indexes were calculated by using two stable isotopic tracers in 8 women; 6 were studied both during lactation and nonlactation. Women consumed low calcium diets, with half receiving supplemental calcium. Intestinal absorption was related to serum 1,25-dihydroxyvitamin D and did not increase during lactation. Despite decreased urinary calcium excretion during lactation, especially in women with low calcium intake, net balance tended to be lower during lactation. Mean residence time decreased and bone resorption exceeded accretion in almost all lactating women. Calcium need for milk production appears to be met by decreased urinary excretion and increased bone resorption, and not by increased intestinal absorption.
authors.affiliation: Department of Pediatrics, University of Cincinnati Medical Center, OH 45267-0541.
authors.forename: B L
authors.initials: BL
authors.lastname: Specker
authors.forename: N E
authors.initials: NE
authors.lastname: Vieira
authors.forename: K O
authors.initials: KO
authors.lastname: O'Brien
authors.forename: M L
authors.initials: ML
authors.lastname: Ho
authors.forename: J E
authors.initials: JE
authors.lastname: Heubi
authors.forename: S A
authors.initials: SA
authors.lastname: Abrams
authors.forename: A L
authors.initials: AL
authors.lastname: Yergey
mesh_terms: D000328:Adult; D001942:Breast Feeding; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D002127:Calcium Isotopes; D002136:Calcium, Dietary; D004032:Diet; D005260:Female; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007700:Kinetics; D007774:Lactation / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism
chemical_list: D002127:Calcium Isotopes; D002136:Calcium, Dietary; D010758:Phosphorus; D002117:Calcitriol; D002118:Calcium