title: Multinucleate cell angiohistiocytoma: a distinct entity diagnosable by clinical and histologic features.
abstract: BACKGROUND
  Multinucleate cell angiohistiocytoma is a newly described entity; examples from the United States have not yet been reported.
  
  
  OBJECTIVE
  Our purpose was to analyze the clinical and histologic features of this entity and confirm or refute its existence.
  
  
  METHODS
  Seven cases were analyzed clinically and by light microscopy.
  
  
  RESULTS
  Multinucleate cell angiohistiocytoma typically occurs in middle-aged women and consists of multiple, grouped, red-brown to violaceous papules that are dome-shaped or flat-topped, roundish and smooth in outline, sharply circumscribed, and occasionally coalescent. Typical sites are the legs, thighs, and backs of hands and fingers. Microscopic features are an increased number of blood vessels (usually capillaries and venules) that are small, rounded, and not well grouped, together with multinucleated histiocyte-like cells with scalloped borders.
  
  
  CONCLUSIONS
  Multinucleate cell angiohistiocytoma is a distinct entity that is diagnosable clinically and histopathologically.
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: P E
authors.initials: PE
authors.lastname: Shapiro
authors.forename: M P
authors.initials: MP
authors.lastname: Nova
authors.forename: L A
authors.initials: LA
authors.lastname: Rosmarin
authors.forename: A J
authors.initials: AJ
authors.lastname: Halperin
mesh_terms: D000368:Aged; D018322:Angiofibroma / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology