title: Adverse reactions due to indocyanine green.
abstract: BACKGROUND
  Although adverse reactions to indocyanine green (ICG) are known to occur, the dye has been used for more than 30 years in tests of cardiac and hepatic function, with a high level of safety. Improved digital video technology has renewed interest in the use of intravenous ICG in ophthalmic imaging. This report describes the authors' experience regarding the safety of ICG for digital angiography and their recommendations for its use in the ophthalmic setting.
  
  
  METHODS
  Digital ICG videoangiography was performed in 1226 consecutive patients, and 1923 ICG videoangiography tests were performed. A registry of adverse reactions to ICG was established. Criteria were used to define mild, moderate, and severe adverse reactions, and these data were recorded for every ICG study performed.
  
  
  RESULTS
  There were three (0.15%) mild adverse reactions, four (0.2%) moderate reactions, and one (0.05%) severe adverse reaction. There were no deaths.
  
  
  CONCLUSIONS
  This study documents the safety of intravenous ICG for use in ophthalmic videoangiography.
authors.affiliation: LuEsther T. Mertz Retinal Research Laboratory, Manhattan Eye, Ear and Throat Hospital, New York, NY 10021.
authors.forename: M
authors.initials: M
authors.lastname: Hope-Ross
authors.forename: L A
authors.initials: LA
authors.lastname: Yannuzzi
authors.forename: E S
authors.initials: ES
authors.lastname: Gragoudas
authors.forename: D R
authors.initials: DR
authors.lastname: Guyer
authors.forename: J S
authors.initials: JS
authors.lastname: Slakter
authors.forename: J A
authors.initials: JA
authors.lastname: Sorenson
authors.forename: S
authors.initials: S
authors.lastname: Krupsky
authors.forename: D A
authors.initials: DA
authors.lastname: Orlock
authors.forename: C A
authors.initials: CA
authors.lastname: Puliafito
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D000075202:Contraindications; D005260:Female; D006801:Humans; D015994:Incidence; D007208:Indocyanine Green / Q000009:adverse effects*; D007275:Injections, Intravenous; D008297:Male; D012164:Retinal Diseases / Q000175:diagnosis; D013575:Syncope / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced; D014741:Video Recording
chemical_list: D007208:Indocyanine Green