title: Development of pattern ERG and pattern VEP spatial resolution in kittens with unilateral esotropia.
abstract: OBJECTIVE
  To follow the development of strabismic amblyopia longitudinally by comparing mean amplitudes and the visual spatial resolving ability of retinal and cortical pattern responses at various stages of postnatal development in unilateral iatrogenic convergent strabismic kittens.
  
  
  METHODS
  Surgery to produce iatrogenic convergent strabismus was performed on 20 kittens at 3 weeks of age; three kittens were used for controls. The monocular transient pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) were recorded simultaneously on the 23 kittens throughout development.
  
  
  RESULTS
  The PVEPs of the strabismic eyes were very reduced at 4 to 5 postnatal weeks (P < 0.01). The reduction increased at 6 to 16 weeks but was even worse at 17 to 30 weeks. The PERG of the squinting eye showed only a slight reduction in the first 4 to 5 weeks of age (P > 0.05), the decrease of responses was significant (P < 0.01) at 6 to 16 weeks and 17 to 30 weeks. At 4 to 8 weeks of age, the PVEP evoked through the unoperated eye in kittens consisted mainly of two positive components of similar amplitude. During development, the slow component decreased in comparison to the fast one, and its peak shifted forward until it merged into the fast (P100) component.
  
  
  CONCLUSIONS
  Esotropic amblyopia did affect the PERG and the PVEP in the amblyopic eye, but the effect on the PERG was less severe, had slower onset, and did not continue as long as for the PVEP.
authors.affiliation: Shanghai Institute of Physiology, Chinese Academy of Sciences.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Yin
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Pei
authors.lastname: Vaegan
authors.forename: Q X
authors.initials: QX
authors.lastname: Fang
mesh_terms: D000550:Amblyopia / Q000503:physiopathology; D000818:Animals; D002415:Cats; D004596:Electroretinography; D004948:Esotropia / Q000503:physiopathology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005123:Eye / Q000254:growth & development; D009801:Oculomotor Muscles / Q000601:surgery; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012160:Retina / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology