Synthesis and anticonvulsant properties of some novel quinazolinone thiazolidine and 4-thiazolidone derivatives.
A series of quinazolinone thiazolidine and 4-thiazolidone derivatives were prepared. The structure of the isolated products have been confirmed by elemental analyses, spectroscopic data and ambiguous synthesis in certain cases. Some of these compounds were effective against seizures induced by pentetrazol.
el-Feky
S A
SA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Fateh University, Libya.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D011799:Quinazolines; D013844:Thiazoles; D010433:Pentylenetetrazole