title: The role of radiation treatment in management of extrahepatic biliary tract metastasis from gastric carcinoma.
abstract: OBJECTIVE
  To determine the proper role of radiation treatment in the management of patients with extrahepatic biliary tract metastasis due to recurrent gastric cancer.
  
  
  METHODS
  Twenty patients with malignant biliary obstruction due to recurrent gastric carcinoma after gastrectomy were treated with palliative intent at the Yonsei University College of Medicine from 1986 to 1990. Treatment consisted of external drainage alone in 11 patients (Group I) and external drainage followed by radiation treatment in nine patients (Group II). Five of nine patients in Group II underwent external irradiation in combination with intraluminal brachytherapy using high dose rate Iridium-192 (Ir-192) sources within the expandable intrabiliary prosthesis, a Gianturco stent, inserted transhepatically at the site of obstruction.
  
  
  RESULTS
  An excellent local response was observed in five of nine patients in Group II, in whom biliary patency was restored following treatment so that the external drainage catheter could be removed. Prolongation of median survival was observed in Group II (9 months) as compared to Group I (2 months). There were no serious treatment-related complications with this approach.
  
  
  CONCLUSIONS
  This treatment approach with external radiotherapy +/- intraluminal brachytherapy could achieve effective palliation and improve the quality of life in selected patients with extrahepatic biliary metastasis from gastric carcinoma.
authors.affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Seoul, Korea.
authors.forename: G E
authors.initials: GE
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Shin
authors.forename: J S
authors.initials: JS
authors.lastname: Seong
authors.forename: J J
authors.initials: JJ
authors.lastname: Loh
authors.forename: C O
authors.initials: CO
authors.lastname: Suh
authors.forename: J T
authors.initials: JT
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Roh
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: W H
authors.initials: WH
authors.lastname: Kim
authors.forename: M W
authors.initials: MW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D017734:Bile Ducts, Extrahepatic; D001918:Brachytherapy; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D007496:Iridium Radioisotopes