Isolation, structural determination and expression of a novel reg gene, human regI beta.
We have isolated a novel human gene and cDNA encoding a member of the regI proteins, regI beta. The gene encodes a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human reg protein, regI alpha. RegI beta was expressed only in pancreas, whereas regI alpha was expressed in kidney and stomach as well as in pancreas.
Moriizumi
S
S
Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan.
Watanabe
T
T
Unno
M
M
Nakagawara
K
K
Suzuki
Y
Y
Miyashita
H
H
Yonekura
H
H
Okamoto
H
H
D000595:Amino Acid Sequence; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D018076:DNA, Complementary / Q000032:analysis; D015870:Gene Expression; D006023:Glycoproteins; D006801:Humans; D051847:Lithostathine; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D010179:Pancreas / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D006023:Glycoproteins; D051847:Lithostathine; D009419:Nerve Tissue Proteins; C497617:REG1A protein, human; C497618:REG1B protein, human