A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic indices.
This study investigated potential therapeutic differences between Amlodipine 5 mg and Felodipine ER 10 mg in 12 normotensive/borderline hypertensive subjects by comparison of the plasma drug concentration-time profiles and the blood pressure and heart rate responses. There was significantly less trough-to-peak variability in plasma drug concentrations with amlodipine with a ratio of 67%, compared to 37% for felodipine. Correspondingly there was less variability with amlodipine in the blood pressure reductions across the dosage interval. Overall, amlodipine displayed a more consistent hypotensive effect across 24 hours and lower blood pressure values at trough, i.e. 24 hours post-dose.
Bainbridge
A D
AD
Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
Herlihy
O
O
Meredith
P A
PA
Elliott
H L
HL
D000368:Aged; D017311:Amlodipine / Q000493:pharmacokinetics* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D003692:Delayed-Action Preparations; D015736:Felodipine / Q000493:pharmacokinetics* / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D003692:Delayed-Action Preparations; D017311:Amlodipine; D015736:Felodipine