Sedation from H1 antagonists: evaluation methods and experimental results.
Sedation is the most frequent and troublesome side effect of H1-antagonists, since it can impair many psycho-motor performances of working and social life. As these drugs are largely employed for the treatment of allergic diseases, both in adults and children, an evaluation of sedation must be accurately performed by standardized tests. In the present work, authors briefly describe the most important clinical tests and summarize the results from the recent literature about the new H1-antagonists.
Passalacqua
G
G
Allergy and Clinical Immunology, DIMI Dipartimento di Medicina Interna, University of Genoa.
Scordamaglia
A
A
Ruffoni
S
S
Parodi
M N
MN
Canonica
G W
GW
D000328:Adult; D016589:Astemizole / Q000009:adverse effects; D017332:Cetirizine / Q000009:adverse effects; D002648:Child; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D017336:Loratadine / Q000009:adverse effects; D009483:Neuropsychological Tests; D011596:Psychomotor Disorders / Q000139:chemically induced / Q000175:diagnosis; D011597:Psychomotor Performance / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects*; D016593:Terfenadine / Q000009:adverse effects
D006634:Histamine H1 Antagonists; D017336:Loratadine; D016593:Terfenadine; D016589:Astemizole; D017332:Cetirizine