The decanoates of flupenthixol and clopenthixol in the treatment of chronic schizophrenic in-patients. Implications for community psychiatry.
Vagrant chronic schizophrenic subjects in a stable untreated state received in-patient treatment with either Flupenthixol decanoate or Clopenthixol decanoate. Both drugs were found to be significantly effective and well tolerated. The apparent better response to Flupenthixol decanoate was seen as dose-dependent. The findings and their implications for Community Psychiatry, particularly in developing countries are discussed.
Martyns-Yellowe
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Neuropsychiatric Hospital, Rumuigbo, Port-Harcourt.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D003006:Clopenthixol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003158:Community Psychiatry; D003692:Delayed-Action Preparations; D003906:Developing Countries; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005475:Flupenthixol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006703:Ill-Housed Persons; D006801:Humans; D007297:Inpatients; D008297:Male; D009549:Nigeria; D011330:Prisons; D011446:Prospective Studies; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016312:Treatment Refusal
D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D014149:Tranquilizing Agents; C029674:clopenthixol decanoate; C007761:flupenthixol decanoate; D003006:Clopenthixol; D005475:Flupenthixol