Patterns of proliferation and differentiation of adult myoblasts define a unique myogenic population.
In here we summarize some of our recent studies on adult chicken myoblasts. We discuss a) myosin isoform expression by the differentiated myoblasts, and b) the role of PDGF during proliferation of the cells. These studies demonstrate that adult myoblasts represent a unique myogenic population (or lineage) which emerges in late development. Furthermore, we discuss possible lineal relationship between adult and somitic/limb bud cells. Unless otherwise noted, the source of myoblasts was chicken pectoralis muscle, and all procedures and antibodies were as described in previous publications (Yablonka-Reuveni, et al., 1987; Yablonka-Reuveni and Seifert, submitted; Hartley, et al., 1991; 1992).
Yablonka-Reuveni
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Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D005121:Extremities / Q000196:embryology; D024510:Muscle Development; D009132:Muscles / Q000166:cytology* / Q000196:embryology; D009218:Myosins / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011784:Quail / Q000196:embryology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D009218:Myosins