Fluconazole: pharmacokinetics and indications.
Fluconazole is a new systemic azole antifungal agent, with the imidazole group substituted by a triazole, presenting a decrease in lipophilicity, soluble in water, weakly bound to plasma proteins, and a wide range of formulations. The time to reach steady-state with a once daily dosage is approximately 7 days. Distribution of fluconazole is extensive and even throughout the tissues, and the drug circulates as a free drug. Half-life elimination is approximately 30 h. Indications are given for fungal infections in AIDS patients and mycoses.
Montero-Gei
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Escuela de Ciencias Médicas, Universidad Autónoma de Centro América (UCA), San José, Costa Rica.
D000818:Animals; D015725:Fluconazole / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy*
D015725:Fluconazole