Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
Sliskovic
D R
DR
Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105.
Krause
B R
BR
Picard
J A
JA
Anderson
M
M
Bousley
R F
RF
Hamelehle
K L
KL
Homan
R
R
Julian
T N
TN
Rashidbaigi
Z A
ZA
Stanfield
R L
RL
D000042:Absorption; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001682:Biological Availability; D002219:Carbamates / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006937:Hypercholesterolemia / Q000517:prevention & control; D007093:Imidazoles / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D010671:Phenylurea Compounds / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology; D014867:Water
D000924:Anticholesteremic Agents; D002219:Carbamates; D002788:Cholesterol Esters; D007093:Imidazoles; D008055:Lipids; D010671:Phenylurea Compounds; D014867:Water; C086204:((2,6-bis(1-methylethyl)phenoxy)sulfonyl)carbamic acid 2,6-bis(1-methylethyl)phenyl ester; D014508:Urea; C050492:CL 277082; D002784:Cholesterol; C084073:lecimibide; D002785:Sterol O-Acyltransferase