Atrial natriuretic peptide and acute myocardial infarction: critical reappraisal.
The present investigation was designed to assess the correlation of atrial natriuretic peptide (ANP) with the ordinary markers of acute myocardial infarction (AMI). In 15 patients with uncomplicated AMI, no remarkable variation in ANP plasma levels was found. On the other hand, serum myoglobin and cardiac enzymes behaved as usual. Our results show that ANP is not correlated with serum myoglobin, creatine-phosphokinase and its isoenzyme MB, being completely independent from these markers of myocardial injury. These observations suggest that the plasma ANP variations observed in AMI by other investigators are probably dependent on hemodynamic dysfunction.
Viti
A
A
Institute of Human Physiology, University of Siena, Italy.
Maioli
E
E
Billi
M
M
Pacini
A
A
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009211:Myoglobin / Q000097:blood
D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D009320:Atrial Natriuretic Factor; D003402:Creatine Kinase