title: Nonsteroidal antiinflammatory drugs lower ethanol-mediated liver increase in lipids and thiobarbituric acid reactive substances.
abstract: Four nonsteroidal antiinflammatory drugs--namely, acetylsalicylic acid, naproxen, nimesulide, and dipyrone--were assayed to search their capability in preventing the hepatic increase of triacylglycerols and thiobarbituric acid reactive substances, as an indication of lipid peroxidation, resulting from the acute intoxication of rats with ethanol. The four antiinflammatory compounds inhibited the ethanol-mediated increase in triacylglycerols and thiobarbituric acid reactive substances. Furthermore, each one of these antiinflammatory drugs produced distinctive actions on blood ethanol levels: a temporal diminution with aspirin and naproxen, no changes with nimesulide, and an increase with dipyrone. It is concluded that the nonsteroidal antiinflammatory drugs contributed to controlling hepatic lipid peroxidation, and hence the oxidative stress promoted by ethanol intoxication.
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de Mexíco, D.F.
authors.forename: M
authors.initials: M
authors.lastname: Zentella de Piña
authors.forename: Y
authors.initials: Y
authors.lastname: Saldaña-Balmori
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Tobías
authors.forename: E
authors.initials: E
authors.lastname: Piña
mesh_terms: D000435:Alcoholic Intoxication / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D004177:Dipyrone / Q000494:pharmacology; D000431:Ethanol / Q000493:pharmacokinetics / Q000633:toxicity; D005235:Fatty Liver, Alcoholic / Q000473:pathology*; D005609:Free Radicals; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology; D009288:Naproxen / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013449:Sulfonamides / Q000494:pharmacology; D013858:Thiobarbiturates / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D013449:Sulfonamides; D013858:Thiobarbiturates; D014280:Triglycerides; D000431:Ethanol; D009288:Naproxen; D004177:Dipyrone; C029684:thiobarbituric acid; D001241:Aspirin; C012655:nimesulide