Parental origins of chromosome 7 loss in childhood monosomy 7 syndrome.
Bone marrow monosomy 7 (Mo 7) is associated with childhood preleukemic myeloproliferative and myelodysplastic syndromes (MPS and MDS). We used a series of polymorphic markers to investigate the parental origins of chromosomes lost from the bone marrows of 12 children with MPS/MDS and Mo 7. Eight Mo 7 bone marrows lost a maternal chromosome 7 and four cases lost the paternal homologue. Our data and the results of previous laboratory and clinical observations in the familial and sporadic forms of childhood Mo 7 suggest that chromosome 7 deletions contribute to leukemogenesis by gene dosage.
Savage
P
P
Department of Internal Medicine, US Naval Hospital, Oakland, CA.
Frenck
R
R
Paderanga
D
D
Emperor
J
J
Shannon
K M
KM
D001853:Bone Marrow; D002648:Child; D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D008297:Male; D009006:Monosomy / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D010375:Pedigree; D011289:Preleukemia / Q000235:genetics
D005819:Genetic Markers