title: Depressive mania associated with nonresponse to antimanic agents.
abstract: Of 39 patients consecutively admitted for the treatment of primary mania, 21 (53.8%) simultaneously met the Research Diagnostic Criteria for major depressive disorder ("mixed" or "depressive" mania). Only nine (42.9%) of the 21 patients with depressive mania responded to antimanic agents. In contrast, 16 (88.9%) of the 18 patients with pure mania responded to these drugs. This finding is consistent with previous reports suggesting that the mixed state is a virulent form of mania.
authors.affiliation: Harris County Psychiatric Center, Department of Psychiatry and Behavioral Sciences, University of Texas School of Medicine, Houston 77021.
authors.forename: S C
authors.initials: SC
authors.lastname: Dilsaver
authors.forename: A C
authors.initials: AC
authors.lastname: Swann
authors.forename: A M
authors.initials: AM
authors.lastname: Shoaib
authors.forename: T C
authors.initials: TC
authors.lastname: Bowers
authors.forename: M T
authors.initials: MT
authors.lastname: Halle
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D004359:Drug Therapy, Combination; D004565:Electroconvulsive Therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents