title: Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity.
abstract: Streptomyces filipinensis NR 0484 produced a new DNA gyrase inhibitor, cyclothialidine. It showed potent activity against DNA gyrases from Escherichia coli and Micrococcus luteus.
authors.affiliation: Nippon Roche Research Center, Kanagawa, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Nakada
authors.forename: S
authors.initials: S
authors.lastname: Sawairi
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: S
authors.initials: S
authors.lastname: Ohshima
authors.forename: T
authors.initials: T
authors.lastname: Kamiyama
authors.forename: M
authors.initials: M
authors.lastname: Arisawa
mesh_terms: D000818:Animals; D002417:Cattle; D004926:Escherichia coli / Q000201:enzymology; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000201:enzymology; D010456:Peptides, Cyclic; D011758:Pyrroles / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D059005:Topoisomerase II Inhibitors
chemical_list: D006571:Heterocyclic Compounds; D010456:Peptides, Cyclic; D011758:Pyrroles; D059005:Topoisomerase II Inhibitors; C085889:cyclothialidine