title: [Acceptance, side-effects and reactive ability after medicamentous anxiolysis with midazolam. A prospective study with 519 gastroscopy and 506 colonoscopy patients].
abstract: In a prospective study 519 patients had gastroscopy (393 with and 126 without midazolam-premedication) and 506 patients had colonoscopy (377 with and 129 without midazolam-premedication) to evaluate acceptance, adverse reactions and reactivity after midazolam-premedication in outpatients immediately and 24 hours later by standard telephone interview. Patients could choose whether they would have midazolam or not. Normally 2 mg midazolam for gastroscopy and 4 mg for colonoscopy were given intravenously directly before endoscopy. 71.5% of gastroscopy and 75.3% of colonoscopy patients who received midazolam afterwards accepted endoscopy only with premedication. 27.7% of our gastroscopy and 14.1% of the colonoscopy patients who than received midazolam were beforehand unable to decide about premedication by themselves. 27.5% of the gastroscopy and 13.8% of the colonoscopy group were persuaded to have midazolam by the doctor examining. 12.7% of our gastroscopy- and 27.1% of our colonoscopy-patients who wished to have midazolam were persuaded to withdraw from it. There were no cardio-pulmonal complications but fatigue was found in 35.4% of the gastroscopy Patients with and 11.9% of those without premedication; colonoscopy patients: 50.4% with and 34.9% without premedication. The incidence of headache was: gastroscopy patients: 6.4% vs. 4%; colonoscopy patients: 11.1% vs. 10.9%. Dizziness: gastroscopy patients: 6.4% vs. 3.2%; colonoscopy patients: 7.6% vs. 7%. Nausea and vomiting were rare (0 to 5%).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Institut für Endoskopie und Proktologie, Köln.
authors.forename: K
authors.initials: K
authors.lastname: Landefeld
authors.forename: H
authors.initials: H
authors.lastname: Rohde
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Eisebitt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D003113:Colonoscopy / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005773:Gastroscopy / Q000523:psychology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010865:Pilot Projects; D011292:Premedication; D011446:Prospective Studies
chemical_list: D008874:Midazolam
vernacular_title: Akzeptanz, unerwünschte Wirkungen und Reaktionsvermögen nach medikamentöser Anxiolyse mit Midazolam. Eine prospektive Studie mit 519 Gastrokopie- und 506 Koloskopiepatienten.