[Human monoclonal antibodies directed to lung cancer].
The need for efficient production of human monoclonal antibodies to tumor-associated antigens is increasing. A study of human monoclonal antibody 904F produced from the regional lymph nodes of a patient with squamous cell carcinoma of the lung was described. By immunohistological study, the 904F antibody has been found to be a new human monoclonal antibody which might be a candidate for clinical application. The second part of the study reports the successful production of human monoclonal antibodies directed to lung cancer by active in vivo immunization of a PBL-SCID mouse (a severe combined immunodeficient mouse grafted with human peripheral blood lymphocytes) with squamous carcinoma cells. These human monoclonal antibodies are promising for the detection and therapy of cancer.
Kudo
T
T
Institute of Development, Aging and Cancer, Tohoku University.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D002459:Cell Fusion; D006801:Humans; D006825:Hybridomas; D008175:Lung Neoplasms / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice
D000911:Antibodies, Monoclonal