Biology of interleukin-1 (IL-1), with respect to otorhinolaryngology-head and neck surgery.
Interleukin-1 (IL-1) has a number of fundamental immunoregulatory, hematologic, metabolic, and physiologic effects and thus is instrumental in the coordination of tissue interactions, such as wound healing, inflammation, and host tumor response. IL-1 stimulates the activation and differentiation of pre-B cells and T cells, chemotaxis of neutrophils, recruitment of bone marrow stem cells, stimulation of arachidonic acid metabolism, degradation of proteoglycans, and increase in basal body temperature. Altered production of IL-1 or IL-1 regulatory factors may have profound clinical consequences, such as seen in AIDS, other viral and malignant diseases, and in uncontrolled inflammatory processes. A variety of positive and negative feedback mechanisms for regulation of IL-1 production have been found; therapeutic interventions are aimed at these regulatory pathways. Through approaches interfering with the signal transduction or processing of IL-1, especially by interleukin-1-receptor antagonists (IL-1RA), future treatment modalities are on the horizon.
Wustrow
T P
TP
Klinik und Poliklinik fur Hals-Nasen-Ohrenkranke, Ludwig-Maximilians-Universitat, Munich, Germany.
D001669:Biochemical Phenomena; D001671:Biochemistry; D001695:Biology; D006257:Head / Q000601:surgery; D006801:Humans; D007375:Interleukin-1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D009333:Neck / Q000601:surgery; D010038:Otorhinolaryngologic Diseases / Q000601:surgery*
D007375:Interleukin-1