Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis.
The effects of psychological stress on serotonin (5-HT) release were studied in the basolateral amygdaloid nucleus and the prefrontal cortex in conscious rats with in vivo microdialysis. Psychological stress, wherein emotional factors were predominantly involved, significantly increased extracellular 5-HT levels in these two areas. These findings suggest that activation of serotonergic neurons in these brain regions is involved in the emotional and/or cognitive states in animals.
Kawahara
H
H
Department of Dental Anesthesiology, Kyushu Dental College, Fukuoka, Japan.
Yoshida
M
M
Yokoo
H
H
Nishi
M
M
Tanaka
M
M
D000161:Acoustic Stimulation; D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D004597:Electroshock; D005110:Extracellular Space / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D017374:Paroxetine / Q000378:metabolism; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D012903:Smell / Q000502:physiology; D013315:Stress, Psychological / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D012701:Serotonin; D017374:Paroxetine; D013779:Tetrodotoxin