[Experimental study on extract of Dunaliella salina in preventing NSAR-induced cancer of proventriculus in mice].
The preventive effect of the extracts of Dunaliella Salina (EDS) on NSAR-induced squamous cell cancer of proventriculus in mice was investigated. Results showed beta-carotene (BC) and DEC could significantly inhibit NSAR-induced carcinogenesis. The greatest inhibition effect was achieved in high-does- EDS group, with an inhibitory rate of 55.6%, but not significantly different from that in BC group (P > 0.05). The proliferation of spleen cells and production of tumour necrosis factor (TNF) by the peritoneal macrophages markedly enhanced in both BC and EDS groups of mice. These findings suggested the prevention of NSAR-induced cancer of proventriculus in mice may be resulted from enhancement of cell immunity.
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Laboratory Centre for Medical Sciences Henan Medical University, Zhengzhou.
D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000517:prevention & control*; D002338:Carotenoids / Q000627:therapeutic use*; D056890:Eukaryota / Q000737:chemistry; D005260:Female; D008297:Male; D051379:Mice; D009602:Nitrosamines; D010936:Plant Extracts / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D002273:Carcinogens; D009602:Nitrosamines; D010936:Plant Extracts; C028099:N-nitrososarcosine ethyl ester; D002338:Carotenoids