[A comparative study of the effect of inhibitors of microbial origin on different alpha-glucosidases].
The action of a new alpha-glucosidase inhibitor from Streptomyces sp. and Acarbose on alpha-glucosidases of various origins has been studied. Differences in specificity, efficiency, nature and type of inhibition of microbial glucosidases and some enzymes of the small intestine mucosa by the biologically active substances studied were revealed. At certain concentrations these inhibitors can be substrates for some intestinal glucosidases. It is suggested that the inhibitor from Streptomyces sp. (in combination with a diet) can be used for regulation of some disturbances in carbohydrate metabolism.
Akulova
N Iu
NIu
Kazanina
G A
GA
Selezneva
A A
AA
D020909:Acarbose; D000818:Animals; D065089:Glycoside Hydrolase Inhibitors; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D013302:Streptomyces / Q000378:metabolism*; D013379:Substrate Specificity; D014312:Trisaccharides / Q000494:pharmacology
D065089:Glycoside Hydrolase Inhibitors; D007527:Isoenzymes; D014312:Trisaccharides; D020909:Acarbose
Sravnitel'noe izuchenie deĭstviia ingibitorov mikrobnogo proiskhozhdeniia na razlichnye alpha-gliukozidazy.