Hypereosinophilic syndrome in childhood: trisomy 8 and transformation to mixed acute leukaemia.
We report a pediatric case of hypereosinophilic syndrome (HES) with trisomy 8 and terminal blastic transformation to mixed acute leukaemia. Literature cases are reviewed, with emphasis on prognostic factors to differentiating "benign" from malignant HES.
Guitard
A M
AM
Laboratoire de Biologie, Faculté de Pharmacie, Hôpital d'Enfants de la Timone, Marseille, France.
Horschowski
N
N
Mozziconacci
M J
MJ
Michel
G
G
George
F
F
Capodano
A M
AM
Perrimond
H
H
D000208:Acute Disease; D002648:Child; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics*; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008213:Lymphocyte Activation; D011237:Predictive Value of Tests; D014314:Trisomy