Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in a renal transplant recipient after the occurrence of pancreatitis due to stibogluconate.
A case of a renal transplant recipient who developed pancreatitis during stibogluconate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported. The features of this case are compared with those of the three previously reported cases of pancreatitis during stibogluconate treatment. Complete cure was achieved during the follow-up period of 15 months. If stibogluconate is used for treatment of renal transplant recipients, we advise extreme caution with close observation and combination therapy to be considered instead.
Halim
M A
MA
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Alfurayh
O
O
Kalin
M E
ME
Dammas
S
S
al-Eisa
A
A
Damanhouri
G
G
D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use*; D000967:Antimony Sodium Gluconate / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D016030:Kidney Transplantation; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010195:Pancreatitis / Q000139:chemically induced*
D000493:Allopurinol; D007654:Ketoconazole; D000967:Antimony Sodium Gluconate