[Mechanism of action of ecdysterone in chickens with D-hypovitaminosis. Early phase of effect].
Early action of ecdysterone in enterocytes of thin intestine of chickens with experimental D-hypovitaminosis has been studied with the aim to find out molecular mechanisms of its action. Changes in biosynthesis of nucleic acids accompanied with normalization of Ca translocation, biosynthesis of proteins, lipids and nucleic acid precursors (purine and pyrimidine nucleotides) as well as oxypurines were observed over the time interval (0-2 h) after ecdysterone administration. Multifunction character of the early action of ecdysterone indicates to the intermediary mechanism of gene activation by ecdysterone and provides for the availability of the secondary mediator for realization of its biological action in enterocytes.
Kotsiuruba
A V
AV
Akhmed
I
I
Tarakanov
S S
SS
Kholodova
Iu D
IuD
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D004247:DNA / Q000096:biosynthesis; D004441:Ecdysterone / Q000494:pharmacology*; D007422:Intestines / Q000166:cytology / Q000187:drug effects*; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D014176:Protein Biosynthesis; D011685:Purine Nucleotides / Q000096:biosynthesis; D011742:Pyrimidine Nucleotides / Q000096:biosynthesis; D013997:Time Factors; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000378:metabolism
D008055:Lipids; D011685:Purine Nucleotides; D011742:Pyrimidine Nucleotides; D004441:Ecdysterone; D004247:DNA; D002118:Calcium
Izuchenie mekhanizmov deĭstviia ékdisterona u tsypliat s D-gipovitaminozom. Ranniaia faza deĭstviia.