title: Aggregation and predisposition to Ascaris lumbricoides and Trichuris trichiura at the familial level.
abstract: This study examines the persistence of familial aggregation and familial predisposition to Ascaris lumbricoides and Trichuris trichiura infection over 2 periods of treatment and reinfection, in an urban community in Kuala Lumpur, Malaysia. Both parasite species were shown to be aggregated (assessed by the variance to mean ratio) within families at all 3 interventions, although no consistent trend in aggregation was observed over the period of the study. Associations between mean A. lumbricoides and T. trichiura infection levels of families, at all 3 interventions, were highly significant (P < 0.0001), suggesting persistent predisposition at the family level.
authors.affiliation: Department of Biology, Imperial College, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Chan
authors.forename: D A
authors.initials: DA
authors.lastname: Bundy
authors.forename: S P
authors.initials: SP
authors.lastname: Kan
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001196:Ascariasis / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D017164:Ascaris lumbricoides; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005192:Family Health; D006801:Humans; D008137:Longitudinal Studies; D008296:Malaysia / Q000453:epidemiology; D012008:Recurrence; D014257:Trichuriasis / Q000453:epidemiology* / Q000235:genetics