title: X-ray crystal structures of thrombin in complex with D-Phe-Pro-Arg and with small benzamidine- and arginine-based "non-peptidic" inhibitors.
authors.affiliation: Max-Planck-Institut für Biochemie, Martinsried, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Bode
mesh_terms: D000590:Amino Acid Chloromethyl Ketones / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D000991:Antithrombins / Q000378:metabolism*; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D001550:Benzamidines / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D013917:Thrombin / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000590:Amino Acid Chloromethyl Ketones; D000991:Antithrombins; D001550:Benzamidines; D001120:Arginine; D013917:Thrombin; C050815:phenylalanyl-prolyl-arginine chloromethyl ketone-thrombin