Novel targets and catalytic activities of bacterial protein toxins.
Among bacterial protein toxins with intracellular targets, tetanus and botulinum toxins form a group with unique properties. They are absolutely neurospecific and act in the cytosol of neurons. Recent evidence indicates that they are zinc proteases specific for proteins of the neuroexocytosis apparatus.
Schiavo
G
G
Dipartimento di Scienze Biomediche, Università di Padova, Italy.
Poulain
B
B
Benfenati
F
F
DasGupta
B R
BR
Montecucco
C
C
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000494:pharmacology*; D001905:Botulinum Toxins / Q000494:pharmacology*; D008565:Membrane Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology*; D050683:R-SNARE Proteins
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D050683:R-SNARE Proteins; D001905:Botulinum Toxins