Mechanisms and meaning of cellular oxygen sensing in the organism.
Oxygen sensors in the body induce various cell activities to avoid any mismatch between oxygen demand and oxygen supply and to maintain an optimal level of oxygen partial pressure (PO2) in various organs. Oxygen sensing seems to be a well conserved process among procaryontic and eucaryontic cells. The molecular mechanism of oxygen sensing is unknown, but it has been suggested that a hemeprotein is involved that does not participate in the mitochondrial energy production. As examplified on the carotid body and on erythropoietin producing HepG2 cells, a cytochrome b was described for the NAD(P)H oxidase of neutrophiles might be an attractive candidate for this hemeprotein. It is hypothesised that hydrogen peroxide (H2O2) produced by this cytochrome b in direct correlation with cellular PO2, serves as a second messenger to regulate potassium channels or gene expression. One might forsee, that this new concept of oxygen sensing could have an impact on all processes in physiology and pathophysiology which are dealing with reactive oxygen intermediates.
Acker
H
H
Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany.
D000818:Animals; D002344:Carotid Body / Q000378:metabolism; D004921:Erythropoietin / Q000096:biosynthesis; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008954:Models, Biological; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D019255:NADPH Oxidases; D010100:Oxygen / Q000378:metabolism*; D015290:Second Messenger Systems
D004921:Erythropoietin; D006861:Hydrogen Peroxide; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D005978:Glutathione; D010100:Oxygen