Induction of arousal in hibernating European hamsters (Cricetus cricetus L.) by vasopressin infusion in the lateral septum.
Vasopressin immunostaining in the lateral septum of the European hamster (Cricetus cricetus L.) disappears in autumn, at the time of the first appearance of hypothermic periods characteristic to hibernation. Previous results have shown that chronic administration of vasopressin in the lateral septum during winter prevents the expression of hypothermic periods, suggesting a role for this peptide in hibernation. It is now observed that acute infusion of vasopressin, and in 50% of the cases, of a specific vasopressin V1 receptor agonist, during a hypothermic period results in an immediate termination of hypothermia. Infusion of oxytocin or a vasopressin V2 receptor agonist were without effect. The results indicate that the seasonal variation in central vasopressin activity, possibly through an interaction with V1 receptors, may play an important role in the expression of hibernation in the European hamster.
Hermes
M L
ML
CNRS, URA 1332, Université Louis Pasteur, Strasbourg, France.
Kalsbeek
A
A
Kirsch
R
R
Buijs
R M
RM
Pévet
P
P
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001831:Body Temperature / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D003080:Cold Temperature; D006224:Cricetinae; D006605:Hibernation / Q000187:drug effects*; D007267:Injections; D008297:Male; D010121:Oxytocin / Q000494:pharmacology; D017483:Receptors, Vasopressin / Q000187:drug effects / Q000235:genetics; D013739:Testosterone / Q000494:pharmacology; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology*
D017483:Receptors, Vasopressin; D014667:Vasopressins; D013739:Testosterone; D010121:Oxytocin