title: Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
abstract: The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
authors.affiliation: Schering Plough Research Institute, Kenilworth, New Jersey 07033.
authors.forename: R
authors.initials: R
authors.lastname: Mierzwa
authors.forename: A
authors.initials: A
authors.lastname: King
authors.forename: M A
authors.initials: MA
authors.lastname: Conover
authors.forename: S
authors.initials: S
authors.lastname: Tozzi
authors.forename: M S
authors.initials: MS
authors.lastname: Puar
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: S J
authors.initials: SJ
authors.lastname: Coval
authors.forename: S A
authors.initials: SA
authors.lastname: Pomponi
mesh_terms: D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010091:Oximes / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D006633:Histamine Antagonists; D010091:Oximes; C086787:verongamine; D014443:Tyrosine; D003000:Clonidine