Theophylline misadventures: Part II.
Except for overdose ingestions, excessive theophylline serum concentrations can be attributed predominantly to therapeutic misadventure. Utilizing medico-legal case reports as a core, this article considers how theophylline toxicity is manifested in several major organ systems and discusses drug/disease interactions with theophylline that may alter serum theophylline concentrations, necessitating dose adjustments. Theophylline overdose is associated with significant morbidity and mortality risks. Overdose treatment, based on use of serum concentrations, is addressed. An understanding of all these factors can help caregivers avoid theophylline morbidity and mortality in neonatal patients.
O'Donnell
J
J
D002493:Central Nervous System Diseases / Q000139:chemically induced; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002648:Child; D004064:Digestive System / Q000187:drug effects; D004347:Drug Interactions; D062787:Drug Overdose; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D007223:Infant; D008297:Male; D008508:Medication Errors; D013806:Theophylline / Q000493:pharmacokinetics / Q000506:poisoning* / Q000633:toxicity
D013806:Theophylline