Gap junctions and tissue business: problems and strategies for developing specific functional reagents.
The complex and overlapping tissue distribution of different members of the gap junctional connexin protein family is reviewed. Intermixing of different connexins in the building of intercellular channels and translational and posttranslational regulation of gap junctional channels add additional challenges to the interpretation of the possible functions played by gap junction-mediated intercellular communication in tissue business.
Goodenough
D A
DA
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, MA 02115.
Musil
L S
LS
D000818:Animals; D030801:Animals, Genetically Modified; D000906:Antibodies; D002450:Cell Communication / Q000235:genetics / Q000502:physiology; D017630:Connexins / Q000235:genetics / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007202:Indicators and Reagents; D010455:Peptides
D000906:Antibodies; D017630:Connexins; D007202:Indicators and Reagents; D010455:Peptides