[ROC analysis of tumor identification using 201Tl-(I)-chloride and 99mTc-(I)-hexakis (2-methoxy-2-isobutylisonitrile].
We investigated tumor detectability of bronchial carcinoma using 201Tl and 99mTc-MIBI with planar scintigraphy and SPECT. We studied 30 tumor patients and 7 patients with coronary artery disease in a clinical phase III trial. The lung was partitioned into 6 areas, which were read independently, to provide a sufficiently large sample of tumor-free reference regions. We calculated the statistical power for the comparison of sensitivities at a given specificity of 95% (TPF-test) to demonstrate that the subdivision of the lung and the application of the bivariate bi-normal ROC model allows an objective assessment of diagnostic performance even for the small sample size of our study. There were no significant differences between 201Tl and 99mTc-MIBI for both observers; therefore, no advantage of 99mTc-MIBI over 201Tl for tumor scintigraphy could be demonstrated. SPECT was significantly superior to planar scintigraphy and should be preferred for tumor detection in the thorax.
Müller
S P
SP
Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Essen, FRG.
Paas
M
M
Reiners
C
C
D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D002283:Carcinoma, Bronchogenic / Q000000981:diagnostic imaging*; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi
ROC-Analyse der Tumorerkennbarkeit mit 201Tl (I) Chlorid und 99mTc (I) Hexakis (2-Methoxy-2-Isobutylisonitril).