[Gas exchange and transport in the body during acute anemia correction by modified hemoglobin solution or attributed to inhalation of a hyperoxic gas mixture].
Total and specific characteristics of changes in gas exchange and transport, tissue oxygenation, circulatory and respiratory compensatory reactions were examined in three groups of necrotized Wistar rats during acute anemia correction by two methods, replacement of red cell mass loss with modified hemoglobin solution (Hb 4.4 g/dl, P50 21.5 mm Hg) or respiration with a hyperoxic mixture (90% of oxygen in nitrogen). In control animals anemia was induced with blood replacement with 6% albumin solution during atmospheric air inhalation. The studied methods for anemia correction were found to increase oxygen levels in arterial blood and similarly effective in total gas exchange maintenance; however the mechanisms of oxygen delivery from arterial blood to tissues being quite different, use of hemoglobin solution was associated with a number of adverse features in gas transport system, acid-base balance, reactions of minute volumes of circulation and respiration which were caused by changed oxygen-binding characteristics of modified hemoglobin and the presence of high concentrations of free hemoglobin in blood plasma.
Chuĭkin
A E
AE
Ivanov
K P
KP
Stolbov
A L
AL
D000208:Acute Disease; D000280:Administration, Inhalation; D000740:Anemia / Q000378:metabolism* / Q000628:therapy; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism*; D006454:Hemoglobins / Q000627:therapeutic use*; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions
D006454:Hemoglobins; D012996:Solutions; D002245:Carbon Dioxide; D010100:Oxygen
Gazoobmen i transport gazov v organizme pri korrektsii ostroĭ anemii rastvorom modifitsirovannogo gemoglobina ili za schet dykhaniia giperoksicheskoĭ gazovoĭ smes'iu.