Proteins with transcription regulatory properties encoded by human adenoviruses.
Of the more than 30 genes encoded by the adenovirus genome, no less than six have been shown to encode proteins that have transcription regulatory properties. None of them is a sequence-specific DNA-binding protein. They act to modulate the activity of cellular transcription factors by causing their phosphorylation or dephosphorylation, by physically interacting with them, or by dissociating transcription factor inhibitory protein complexes.
Akusjärvi
G
G
Dept of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden.
D017500:Adenovirus E1A Proteins / Q000494:pharmacology; D017501:Adenovirus E1B Proteins / Q000494:pharmacology; D017502:Adenovirus E2 Proteins / Q000494:pharmacology; D000260:Adenoviruses, Human / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D008957:Models, Genetic; D014158:Transcription, Genetic / Q000187:drug effects*; D014764:Viral Proteins / Q000494:pharmacology*
D017500:Adenovirus E1A Proteins; D017501:Adenovirus E1B Proteins; D017502:Adenovirus E2 Proteins; D014764:Viral Proteins