title: Efficacy and retention time of a new tear substitute.
abstract: The tear substitute Lacrozym has been compared with Tears Naturale in a double-blind study. Baseline tear film break-up time, efficiency by determining the maximum of the break-up time values after tear substitute administration, and retention time has been established. A similar increase of break-up time values were found after 10, 15, 20 and 30 min administration of Lacrozym and Tears Naturale, respectively. Retention times of both tear substitutes were found to be about two hours, more exactly 110 and 120 min for Lacrozym and Tears Naturale, respectively.
authors.affiliation: Second Eye Clinic, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Pálfalvi
authors.forename: I L
authors.initials: IL
authors.lastname: Kahán
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000494:pharmacology*; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D013666:Tears / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D002951:Citrates; D004338:Drug Combinations; C086626:Lacrozym; D009883:Ophthalmic Solutions; D019343:Citric Acid; D009113:Muramidase