Nifedipine in rat liver cirrhosis.
Rat liver cirrhosis induced by CCl4+ethanol was employed to assess the effectiveness of nifedipine in reducing liver injury. Nifedipine reduced the severity of hepatocellular necrosis, significantly decreased Mallory bodies (p < 0.01), decreased polymorphonuclear inflammatory infiltrate (p < 0.05) and reduced perivenular fibrosis. Plasma lactic acid levels were significantly increased in the CCl4+ethanol group (p < 0.01). Lactacidaemia remained at normal values when the calcium antagonist blocker was employed. Nifedipine did not significantly alter the incidence of cirrhosis in this experimental model.
Cutrin
C
C
Department of Medicine, Faculty of Medicine, University of Santiago de Compostela, Galicia, Spain.
Menino
J
J
Carballo
C
C
Parafita
M A
MA
Perez-Becerra
E
E
Barrio
E
E
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D000431:Ethanol / Q000633:toxicity; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D007773:Lactates; D019344:Lactic Acid; D000431:Ethanol; D002251:Carbon Tetrachloride; D009543:Nifedipine