title: [Gonadal tumor and Y chromosome].
abstract: The histologic features of gonads occurrence of gonadal tumor, and RIA reproductive hormone levels in 50 cases containing a Y chromosome karyotype were analysed. The correlation between gonadal tumor and Y chromosome, clinical manifestation and genotype, and the principle of diagnosis and treatment are discussed. There were seven cases of gonadal tumor in these fifty cases the frequency of gonadal tumor is 14% (7/50). All of them were present in cases with gonadal dysgenesis, with the frequency rate of 27% (7/26). Five cases were bilateral, and two were unilateral, that made a total of twelve tumors in these seven cases. Gonadoblastoma was type of tumor commonly found, about 75% (9/12). The above date suggested that there is a higher frequency of gonadal tumor in cases of gonadal dysgenesis with a Y chromosome. Both hypergonadotropins and low sex steroids levels were the feature of gonadal dysgenesis, but no relative with occurrence of the tumor. The phenotype of these fifty cases were largely due to the process of abnormal sexual differentiation not only depend on the sex chromosome complement. In treatment, prophylactic bilateral gonadectomy is emphasized.
authors.affiliation: Obstet and Gynecol Hospital, Shanghai Medical University.
authors.forename: C X
authors.initials: CX
authors.lastname: Yu
mesh_terms: D005260:Female; D006059:Gonadal Dysgenesis / Q000150:complications*; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications; D018238:Gonadoblastoma / Q000209:etiology; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000209:etiology*; D012729:Sex Chromosome Aberrations; D013736:Testicular Neoplasms / Q000209:etiology*; D014424:Turner Syndrome / Q000150:complications; D014998:Y Chromosome