title: Cholesterol-lowering and blood pressure effects of immune milk.
abstract: The plasma cholesterol-lowering and blood pressure effects of a skim milk powder (immune milk) produced from dairy cows hyperimmunized with a multivalent bacterial vaccine were assessed in a double-blind crossover study of hypercholesterolemic subjects who consumed daily 90 g immune milk or a normal product. There was a significant reduction in plasma total and LDL cholesterol of 5.2% (95% CI 2.5, 7.9) and 7.4% (95% CI 4.1, 10.7), respectively, with 10 wk of immune milk consumption compared with control, but no change in HDL cholesterol or triglycerides. A significant systolic and diastolic blood pressure-lowering effect (5 and 4 mm Hg, respectively) was also demonstrated. Thus, immune milk may be a useful adjunct in the dietary management of hypercholesterolemia and the mechanisms of its cholesterol-lowering and blood pressure effects warrant further study.
authors.affiliation: Department of Medicine, University of Auckland School of Medicine, New Zealand.
authors.forename: S J
authors.initials: SJ
authors.lastname: Sharpe
authors.forename: G D
authors.initials: GD
authors.lastname: Gamble
authors.forename: D N
authors.initials: DN
authors.lastname: Sharpe
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000924:Anticholesteremic Agents; D001428:Bacterial Vaccines / Q000276:immunology; D001794:Blood Pressure; D002417:Cattle / Q000276:immunology*; D002784:Cholesterol / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000276:immunology* / Q000378:metabolism; D014611:Vaccination
chemical_list: D000924:Anticholesteremic Agents; D001428:Bacterial Vaccines; D002784:Cholesterol