[An analysis of the amino acid sequence of the heavy subunit of the hemagglutinin in influenza virus A/Alma-Ata/1417/84].
An analysis of the amino acid sequence of influenza A/Alma-Ata/1417/84 (H1N1-Hsw1N1 serovariant) virus hemagglutinin heavy chain deduced from the nucleotide sequence of cloned full-size DNA complementary to the 4th segment of genome RNA was carried out. Unlike A/New Jersey/8/76 virus, the hemagglutinin of the virus under study was found to be more similar in the rate of HA1 homology, amino acid sequence of the signal peptide, antigenic sites Sa, Ca, and the receptor-binding site to human influenza viruses isolated in the 1930-1980-ies, in particular to influenza A/Taiwan/1/86 virus. It is assumed that an influenza virus more adapted to the human population like the strain A/Alma-Ata/1417/84 may be an etiological factor of a new influenza pandemic.
Chubakova
Z K
ZK
Beklemishev
A B
AB
Nazarova
L M
LM
Filimonov
N G
NG
Blinov
V M
VM
Grinev
A A
AA
Kim
E V
EV
Mukazhanova
G N
GN
D000595:Amino Acid Sequence; D006389:Hemagglutinins, Viral / Q000235:genetics* / Q000276:immunology; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000235:genetics* / Q000276:immunology; D017386:Sequence Homology, Amino Acid
D006389:Hemagglutinins, Viral; D010446:Peptide Fragments
Analiz aminokislotnoĭ posledovatel'nosti tiazheloĭ sub''edinitsy gemaggliutinina virusa grippa A/Ama-Ata/1417/84.