title: Two new antiinflammatory elemanolides from Centaurea chilensis.
abstract: Two previously undescribed elemanolide esters, the 2-methylpropanoate and 2-methyl-2-propenoate of 11,13-dehydromelitensin, were isolated in the course of a bioassay-guided fractionation from the aerial parts of Centaurea chilensis Hook. et Arn., used traditionally to treat 'gout and rheumatism'. The mixture of both substances exhibits anti-inflammatory activity in the carrageenan-induced paw edema assay.
authors.affiliation: Pharmacognosy Laboratory, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago.
authors.forename: R E
authors.initials: RE
authors.lastname: Negrete
authors.forename: N
authors.initials: N
authors.lastname: Backhouse
authors.forename: I
authors.initials: I
authors.lastname: Cajigal
authors.forename: C
authors.initials: C
authors.lastname: Delporte
authors.forename: B K
authors.initials: BK
authors.lastname: Cassels
authors.forename: E
authors.initials: E
authors.lastname: Breitmaier
authors.forename: G
authors.initials: G
authors.lastname: Eckhardt
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D002351:Carrageenan; D002677:Chile; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C086499:11,13-dehydromelitensin 2-methyl-2-propenoate; C086498:11,13-dehydromelitensin 2-methylpropanoate; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; D010936:Plant Extracts; D002351:Carrageenan