title: Disposition of milrinone in patients after cardiac surgery.
abstract: We have evaluated the disposition of milrinone in seven patients with low cardiac output after elective cardiac surgery involving cardiopulmonary bypass. Patients received a loading dose of milrinone 50 micrograms kg-1 given over 10 min followed immediately by an infusion of 0.5 microgram kg-1 min-1, continued for a minimum of 5 h. Plasma concentrations of milrinone were measured at designated intervals during the infusion and for 6 h after its termination, by high pressure liquid chromatography. Concentrations greater than 100 ng ml-1 were produced in all patients within 2 min of starting the loading dose and were maintained for the duration of the infusion. Volume of distribution, clearance and terminal half-life were similar to those found in patients with chronic cardiac failure.
authors.affiliation: Department of Anaesthetics, Northern General Hospital, Sheffield.
authors.forename: P A
authors.initials: PA
authors.lastname: Das
authors.forename: J R
authors.initials: JR
authors.lastname: Skoyles
authors.forename: K M
authors.initials: KM
authors.lastname: Sherry
authors.forename: J E
authors.initials: JE
authors.lastname: Peacock
authors.forename: P A
authors.initials: PA
authors.lastname: Fox
authors.forename: S G
authors.initials: SG
authors.lastname: Woolfrey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002303:Cardiac Output, Low / Q000097:blood / Q000188:drug therapy*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020105:Milrinone; D011183:Postoperative Complications / Q000188:drug therapy; D011728:Pyridones / Q000097:blood* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D011728:Pyridones; D020105:Milrinone