title: Comparison of clinical outcomes for women and men after acute myocardial infarction. The Thrombolysis in Myocardial Infarction Investigators.
abstract: OBJECTIVE
  To assess differences in morbidity and mortality between men and women with acute myocardial infarction treated with thrombolytic therapy and the relation of differences to baseline patient characteristics and clinical features.
  
  
  METHODS
  Secondary analysis of observational findings among women and men enrolled in a clinical trial.
  
  
  METHODS
  Hospitals participating in the Thrombolysis in Myocardial Infarction Phase II trial.
  
  
  METHODS
  Recurrent infarctions and deaths were assessed.
  
  
  RESULTS
  The 6-week mortality rate was greater for women than for men (9% compared with 4%; adjusted relative risk, 1.54; P = 0.01). Death or reinfarction occurred in 15.9% of women and 9.5% of men (adjusted relative risk, 1.33; P = 0.02). Among patients enrolled for treatment with 100 mg of recombinant tissue plasminogen activator and assigned to a conservative strategy of watchful waiting with appropriate backup, the 6-week incidence of death was 7.5% for women and 3.8% for men (P = 0.01). The 6-week incidences of death or reinfarction were 14.2% and 8.9% (P = 0.01) among women and men, respectively.
  
  
  CONCLUSIONS
  Among patients in the Thrombolysis in Myocardial Infarction Phase II Trial, who all were diagnosed with myocardial infarction and were eligible to receive thrombolytic therapy, women had higher rates of mortality and morbidity than did men. Older age at the time of myocardial infarction and a history of diabetes accounted for much but probably not all of this difference.
authors.affiliation: Thrombosis Research Center, University of Massachusetts Medical School, Worcester.
authors.forename: R C
authors.initials: RC
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Terrin
authors.forename: R
authors.initials: R
authors.lastname: Ross
authors.forename: G L
authors.initials: GL
authors.lastname: Knatterud
authors.forename: P
authors.initials: P
authors.lastname: Desvigne-Nickens
authors.forename: J M
authors.initials: JM
authors.lastname: Gore
authors.forename: E
authors.initials: E
authors.lastname: Braunwald
mesh_terms: D000367:Age Factors; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016277:Ventricular Function, Left
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator