title: In vitro MR imaging of the resected stomach with a 4.7-T superconducting magnet.
abstract: OBJECTIVE
  To study the effects of formalin fixation, signal intensity characteristics of the stomach-wall layers, and findings suggestive of cancerous invasion to the stomach wall in vitro with magnetic resonance (MR) imaging in humans.
  
  
  METHODS
  MR images of nine specimens of stomach cancer and 29 normal specimens were obtained at 4.7 T; 26 of the normal specimens were fixed in 10% formalin for 2 hours to 187 days before imaging. The field gradient was 10 G/cm; the spatial resolution, 0.1 mm.
  
  
  RESULTS
  The mucosal, submucosal, and proper-muscle layers were clearly identifiable. The submucosa of the fresh specimens had the lowest signal intensity of all specimens on both T1- and T2-weighted images (P < .01). No statistical correlation existed between signal intensity and duration of fixation. Tumor invasion was detected in seven of eight specimens with mucosal invasion, all eight specimens with submucosal invasion, and three of six specimens with muscle invasion.
  
  
  CONCLUSIONS
  In vitro MR imaging enabled differentiation of all three layers of the stomach wall, detection of the cancer, and measurement of the depth of invasion.
authors.affiliation: Department of Radiology, Asan Medical Center, University of Ulsan, Seoul, Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Auh
authors.forename: T H
authors.initials: TH
authors.lastname: Lim
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: M G
authors.initials: MG
authors.lastname: Lee
authors.forename: K S
authors.initials: KS
authors.lastname: Cho
authors.forename: C W
authors.initials: CW
authors.lastname: Mun
authors.forename: I
authors.initials: I
authors.lastname: Lee
mesh_terms: D005557:Formaldehyde; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology; D016707:Tissue Fixation
chemical_list: D005557:Formaldehyde