Myoglobin signal as an NMR tissue thermometer: implication for hyperthermia treatment of tumors.
Measuring local tissue temperature is critical in establishing a rational approach for hyperthermia treatment of tumors. We have found that the heme signals of myoglobin provide a unique basis for NMR thermometry in vivo. In particular the 5-methyl heme signal of MbCN exhibits a sharp, temperature-dependent resonance that is distinguishable in the tissue spectrum. Its calibrated chemical shift can then reflect the local tissue temperature in vivo.
Chung
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Department of Biological Chemistry, University of California Davis 95616-8635.
Jue
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D000818:Animals; D001831:Body Temperature; D006979:Hyperthermia, Induced; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles; D009211:Myoglobin / Q000031:analogs & derivatives* / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009211:Myoglobin; C086756:myoglobin cyanide