title: Adaptive behavior of children with symptomatic HIV infection before and after zidovudine therapy.
abstract: Assessed longitudinally the effects of HIV infection and zidovudine on the adaptive behavior of 25 children with symptomatic disease (M age = 5.3 years; range = 1-12; 52% classified as encephalopathic) by parent report using the Vineland Adaptive Behavior Scales. Patients also were evaluated with an age-appropriate intelligence test and Q-sort Behavioral Rating Scale. Before treatment, encephalopathic children exhibited greater impairments in adaptive behavior than those without encephalopathy. After 6 months of zidovudine, all behavioral domains (communication, daily living, socialization) except for motor skills showed overall significant improvement. Children with or without encephalopathy showed a similar degree of change. Improvements in adaptive behavior correlated with increases in cognitive ability and decreases in severity of aberrant social-emotional behavior.
authors.affiliation: Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892.
authors.forename: P L
authors.initials: PL
authors.lastname: Wolters
authors.forename: P
authors.initials: P
authors.lastname: Brouwers
authors.forename: H A
authors.initials: HA
authors.lastname: Moss
authors.forename: P A
authors.initials: PA
authors.lastname: Pizzo
mesh_terms: D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000523:psychology; D000203:Activities of Daily Living / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003142:Communication; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D009042:Motivation; D011779:Q-Sort; D011788:Quality of Life; D012919:Social Behavior; D012951:Socialization; D015215:Zidovudine / Q000008:administration & dosage*
chemical_list: D015215:Zidovudine