title: The role of insulin-like growth factors and epidermal growth factor-related peptides in intraovarian regulation in the pig ovary.
abstract: The autocrine and paracrine role of the insulin-like growth factors (IGFs) and epidermal growth factor (EGF)-related peptides in pig ovary are reviewed. For convenience, each of these regulatory systems is divided into several interactive components: regulated expression of the growth factors, growth factor reception at the cell surface and intracellular action of the growth factors. In addition, the concept of regulated bioavailability and targeting of growth factors in the extracellular space is developed as an important control locus and area for future study. With regard to the IGF system, these components include two ligands--IGF-I and -II, both expressed in the porcine ovary--and the possibility of three receptors. IGF-I and the type I IGF receptor appear to be the most important in stimulating ovarian function and amplifying hormone action. In addition, the 'set-point' of the ovarian IGF system may be determined by the activity of several IGF-binding proteins (IGFBPs). At least four of these proteins are expressed in the pig ovary. Studies of their regulation and action in ovarian cells indicate that they can function as antagonists to FSH and the IGFs. However, preliminary evidence suggests a more dynamic model in which these proteins may direct the site and timing of IGF effects. There are fewer data on the EGF system. At least four EGF-related peptides are expressed in pig ovaries, but insufficient information is available to predict their physiological regulation. These peptides are potent mitogens for ovarian cells.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Penn State University, Hershey 17033.
authors.forename: J M
authors.initials: JM
authors.lastname: Hammond
authors.forename: S E
authors.initials: SE
authors.lastname: Samaras
authors.forename: R
authors.initials: R
authors.lastname: Grimes
authors.forename: J
authors.initials: J
authors.lastname: Leighton
authors.forename: J
authors.initials: J
authors.lastname: Barber
authors.forename: S F
authors.initials: SF
authors.lastname: Canning
authors.forename: H D
authors.initials: HD
authors.lastname: Guthrie
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000502:physiology; D005260:Female; D006133:Growth Substances / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000502:physiology; D010053:Ovary / Q000254:growth & development* / Q000502:physiology; D013552:Swine / Q000254:growth & development*
chemical_list: D006133:Growth Substances; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II