title: [Anti-gastric antibodies and gastritis in insulin-dependent diabetes in children].
abstract: BACKGROUND
  Adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. Knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance.
  
  
  METHODS
  68 patients (29 boys and 39 girls), aged from 5 yr 2 mo to 19 yr 10 mo, and treated for insulin-dependent diabetes from 1 mo to 14 yr 6 mo, were included in the study. Fasting blood concentrations of gastrin (G), pepsinogen (PG1), anti-gastric parietal cell antibodies (PCA) were measured. Fiberoptic endoscopy and biopsy of the gastroduodenal mucosa were performed in PCA+ patients and biopsy samples were examined for Helicobacter pylori (HP).
  
  
  RESULTS
  12 patients were PCA+; 3 of them had blood gastrin levels above 104 pg/ml and 4 had blood pepsinogen levels 24 ng/ml. Histologically, 3 patients had chronic diffuse gastritis (2 were HP+); 2 had chronic gastritis restricted to the antro-pyloric area (both were HP+); 3 had follicular lymphoid hyperplasia (without HP) and 4 had normal mucosa (without HP).
  
  
  CONCLUSIONS
  The presence of PCA can predict the risk of chronic gastritis, possibly auto-immune in origin, in children with insulin-dependent diabetes.
authors.affiliation: Service de Pédiatrie de l'Université de Parme, Italie.
authors.forename: G L
authors.initials: GL
authors.lastname: de'Angelis
authors.forename: G
authors.initials: G
authors.lastname: Apollionio
authors.forename: E
authors.initials: E
authors.lastname: Boselli
authors.forename: A
authors.initials: A
authors.lastname: De Fanti
authors.forename: F
authors.initials: F
authors.lastname: De Luca
authors.forename: S
authors.initials: S
authors.lastname: Fulgido
authors.forename: E
authors.initials: E
authors.lastname: Romanini
authors.forename: M
authors.initials: M
authors.lastname: Vanelli
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000276:immunology; D005756:Gastritis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D010295:Parietal Cells, Gastric / Q000276:immunology*; D010435:Pepsinogens / Q000097:blood; D011237:Predictive Value of Tests
chemical_list: D000906:Antibodies; D010435:Pepsinogens
vernacular_title: Anticorps antiestomac et gastrite au cours du diabète insulino-dépendant de l'enfant.