title: [Sedimentation analyser--calibration and testing of a newly developed device for recording separation behavior of blood and other dispersed systems].
abstract: A computer-aided sedimentation analyser is described, which can be used for the continuous monitoring of the separation of blood and other dispersed systems by recording the separation-dependent infrared transmission in the range between 100 xg to 700 xg. Up to eight samples can be measured simultaneously within a short period of time, and only a small amount of suspension is required (15 minutes, 350 microliters). For centrifugal acceleration more than 100 xg and a haematocrit range of between 0.2 and 0.7, the evolution of the height of the plasma column (HPC) over time is expressed in non-linear regression form by HPC(t) = HPC infinity*(1-e-kt) + c. The separation constant k is influenced by plasma viscosity, haematocrit, aggregability and erythrocyte deformability, is directly proportional to centrifugal acceleration, and declines in hyperbolic fashion with increasing haematocrit between 300 xg and 650 xg. The separation constant is closely related to the maximum velocity which, in fact, represents the sensitive parameter of separation. Thus, the sedimentation analyser can be applied as an alternative to the traditional measurement of erythrocyte sedimentation rate according to Westergren.
authors.affiliation: Institut für Medizinische Physik und Biophysik, Bereich Medizin (Charité) der Humboldt-Universität zu Berlin.
authors.forename: T
authors.initials: T
authors.lastname: Dschietzig
authors.forename: D
authors.initials: D
authors.lastname: Lerche
authors.forename: N
authors.initials: N
authors.lastname: Dunker
mesh_terms: D001799:Blood Sedimentation; D001809:Blood Viscosity; D002138:Calibration; D004903:Erythrocyte Aggregation / Q000502:physiology; D004907:Erythrocyte Deformability / Q000502:physiology; D006400:Hematocrit; D006801:Humans; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
vernacular_title: Sedimentationsanalysator--Eichung und Testung eines neuentwickelten Gerätes zur Aufzeichnung des Entmischungsverhaltens von Blut und anderen dispersen Systemen.