title: Analysis of human growth hormone gene 5' sequences in isolated growth hormone deficiency patients.
abstract: Human growth hormone (hGH) gene deletion (6.7 to 7.6 kb) is one of the causes of isolated growth hormone deficiency (IGHD), named IGHD IA. IGHD IA, however, only accounts for about 10% of the total IGHD patients. Most IGHD is caused by unknown mechanisms. Here, hGH gene 5' sequences in three IGHD patients without hGH gene deletion were analysed to see if there was any mutation hindering the expression of the hGH gene.
authors.affiliation: Department of Biochemistry, Shanghai Second Medical University, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: L L
authors.initials: LL
authors.lastname: Yu
authors.forename: Q
authors.initials: Q
authors.lastname: Sheng
authors.forename: C
authors.initials: C
authors.lastname: Meng
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.forename: S S
authors.initials: SS
authors.lastname: Chen
mesh_terms: D001483:Base Sequence; D015870:Gene Expression; D013006:Growth Hormone / Q000172:deficiency* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D013006:Growth Hormone