Circadian variations of gastrointestinal peptides and cell proliferation in rats: effects of adrenalectomy.
The hypothalamo-pituitary-adrenal axis appears to play an important role in regulating the circadian fluctuations of brain-gut peptides, as well as the cell cycle of the gastrointestinal mucosa. Since dexamethasone treatment tended to restore circadian fluctuations lost to adren-x, the influence of adrenal glucocorticoids in the coordination of the rhythms of regulatory peptides and cell cycle kinetics appears to be substantial.
Pasley
J N
JN
Department of Physiology, Biophysics, and Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205.
Burns
E R
ER
Rayford
P L
PL
D000315:Adrenalectomy; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002766:Cholecystokinin / Q000378:metabolism; D002940:Circadian Rhythm; D003907:Dexamethasone / Q000494:pharmacology; D004947:Esophagus / Q000166:cytology*; D016195:G2 Phase; D005755:Gastrins / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008938:Mitosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D016196:S Phase
D005755:Gastrins; D005768:Gastrointestinal Hormones; D003907:Dexamethasone; D002766:Cholecystokinin