title: Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands.
abstract: Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.
authors.affiliation: Department III, Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Constant
authors.forename: F
authors.initials: F
authors.lastname: Davodeau
authors.forename: M A
authors.initials: MA
authors.lastname: Peyrat
authors.forename: Y
authors.initials: Y
authors.lastname: Poquet
authors.forename: G
authors.initials: G
authors.lastname: Puzo
authors.forename: M
authors.initials: M
authors.lastname: Bonneville
authors.forename: J J
authors.initials: JJ
authors.lastname: Fournié
mesh_terms: D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D002478:Cells, Cultured; D002852:Chromatography, Ion Exchange; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013942:Thymine Nucleotides / Q000032:analysis / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000942:Antigens, Bacterial; D008024:Ligands; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013942:Thymine Nucleotides; C024157:thymidine 5'-triphosphate