title: The treatment and follow up of adult chlamydial ophthalmia.
abstract: Sixty two patients diagnosed as having adult chlamydial ophthalmia were treated with oral doxycycline and roxithromycin in association and tetracycline eye wash for 2 weeks. Chlamydial ophthalmia was diagnosed by laboratory detection of the micro-organism in ocular specimens using direct immunofluorescent monoclonal antibody staining for Chlamydia trachomatis, chlamydial culture in cycloheximide treated McCoy cells, and Giemsa staining. An immunoenzymatic method for detection of specific IgG and IgA in patients' serum was used as an additional test to confirm the diagnosis. All patients were reexamined 3 weeks after completing their course of antibiotics and in the case of persistent infection a further course of treatment was given. With this treatment regimen 48 out of 62 patients (77.4%) were cured after three courses. Because of the risks of an inadequate response to therapy, we recommend a proper post-treatment follow up in all patients with chlamydial eye infections.
authors.affiliation: Istituto di Clinica Oculistica, Università di Sassari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Carta
authors.forename: S
authors.initials: S
authors.lastname: Zanetti
authors.forename: A
authors.initials: A
authors.lastname: Pinna
authors.forename: M
authors.initials: M
authors.lastname: Sotgiu
authors.forename: G
authors.initials: G
authors.lastname: Fadda
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D003235:Conjunctivitis, Inclusion / Q000188:drug therapy*; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D015575:Roxithromycin / Q000627:therapeutic use; D013752:Tetracycline / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D009883:Ophthalmic Solutions; D015575:Roxithromycin; D013752:Tetracycline; D004318:Doxycycline