Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome.
Magnolol and honokiol, biphenyl compounds, were isolated as anti-emetic principles from the methanolic extract of Magnolia obovata bark. [6]-, [8]-, and [10]-shogaols and [6]-, [8]-, and [10]-gingerols were isolated from the methanolic extract of Zingiber officinale rhizome as anti-emetic principles. Some phenyl-propanoids with allyl side-chains were found to show the same activity. They inhibited the emetic action induced by the oral administration of copper sulfate pentahydrate to leopard and ranid frogs.
Kawai
T
T
Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.
Kinoshita
K
K
Koyama
K
K
Takahashi
K
K
D000818:Animals; D000932:Antiemetics / Q000302:isolation & purification / Q000494:pharmacology*; D001001:Anura; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology; D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D017705:Lignans; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D000498:Allyl Compounds; D010636:Phenols
D000932:Antiemetics; D001713:Biphenyl Compounds; D002396:Catechols; D005233:Fatty Alcohols; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C040115:shogaol; C007845:gingerol