title: Effect of ceftibuten on the normal intestinal microflora.
abstract: 14 healthy volunteers were given 400 mg ceftibuten orally once daily for ten days. Stool specimens were collected before, during and after ceftibuten administration. Ceftibuten was well absorbed; on average 123 mg was excreted in urine 0-6 h after dosing, while only two volunteers had detectable concentrations of ceftibuten in faeces (< or = 3.2 mg/kg). There was an overgrowth of enterococci during the administration period, while the numbers of Escherichia coli and anaerobic cocci were reduced. Six volunteers were colonized by Clostridium difficile during days 4 to 17. Beta-lactamase activity was detected in faecal samples from eight volunteers and increased significantly during the administration period.
authors.affiliation: Dept. of Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Brismar
authors.forename: C
authors.initials: C
authors.lastname: Edlund
authors.forename: C E
authors.initials: CE
authors.lastname: Nord
mesh_terms: D000328:Adult; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D000077722:Ceftibuten; D002511:Cephalosporins / Q000493:pharmacokinetics / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects; D005243:Feces / Q000201:enzymology / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D013211:Staphylococcus aureus / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D002511:Cephalosporins; D001618:beta-Lactamases; D000077722:Ceftibuten