title: Hypereosinophilic syndrome in childhood: trisomy 8 and transformation to mixed acute leukaemia.
abstract: We report a pediatric case of hypereosinophilic syndrome (HES) with trisomy 8 and terminal blastic transformation to mixed acute leukaemia. Literature cases are reviewed, with emphasis on prognostic factors to differentiating "benign" from malignant HES.
authors.affiliation: Laboratoire de Biologie, Faculté de Pharmacie, Hôpital d'Enfants de la Timone, Marseille, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Guitard
authors.forename: N
authors.initials: N
authors.lastname: Horschowski
authors.forename: M J
authors.initials: MJ
authors.lastname: Mozziconacci
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: F
authors.initials: F
authors.lastname: George
authors.forename: A M
authors.initials: AM
authors.lastname: Capodano
authors.forename: H
authors.initials: H
authors.lastname: Perrimond
mesh_terms: D000208:Acute Disease; D002648:Child; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics*; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008213:Lymphocyte Activation; D011237:Predictive Value of Tests; D014314:Trisomy