title: Expression of functional trk tyrosine kinase receptors after T cell activation.
abstract: Increasing evidence indicates that nerve growth factor (NGF), in addition to its neurotrophic actions, exerts specific effects on cells of the immune system. This report show that the CD4-positive T cell line 9/6 expresses trk protooncogene, the signal transducing receptor unit for NGF, after TCR-mediated activation by Ag and APC. This receptor is of functional importance because interaction of NGF with Ag-stimulated 9/6 T cells induced the transcriptional activation of the c-fos gene, a hallmark of the biochemical response to NGF. Our findings that neither mitogen nor Ag stimulation induced the expression of the low affinity NGF receptor in 9/6 T cells indicate that trk alone is sufficient to mediate biologic activity of NGF in T lymphocytes.
authors.affiliation: Department of Physiology, University of Basel, Vesalianum, Switzerland.
authors.forename: P B
authors.initials: PB
authors.lastname: Ehrhard
authors.forename: P
authors.initials: P
authors.lastname: Erb
authors.forename: U
authors.initials: U
authors.lastname: Graumann
authors.forename: B
authors.initials: B
authors.lastname: Schmutz
authors.forename: U
authors.initials: U
authors.lastname: Otten
mesh_terms: D001483:Base Sequence; D016762:Genes, fos; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000494:pharmacology; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis* / Q000235:genetics; D020917:Receptor, trkA; D017475:Receptors, Nerve Growth Factor / Q000032:analysis* / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA