title: Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D.
abstract: The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Tomoda
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Sunazuka
authors.forename: R
authors.initials: R
authors.lastname: Obata
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D001232:Aspergillus fumigatus / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
chemical_list: D011725:Pyridines; D012717:Sesquiterpenes; C082792:pyripyropene A; C082793:pyripyropene B; C082794:pyripyropene C; C082795:pyripyropene D; D002785:Sterol O-Acyltransferase