[Effect of parathyroidectomy (PTX) on aluminum (Al) induced bone disease].
Al-treated or untreated decalcified sections of bone matrix were implanted subcutaneously into the abdominal wall of parathyroidectomized (PTX) or control rats for 21 or 28 days. The bone remodeling and Al, Ca content in the implants were measured by using histomorphometry and atomic absorption spectrum method. The results showed that bone area, osteoclast number, osteoblast number and bone mineralization rate of Al-treated or untreated bone in PTX rats and of Al-treated bone in control rats were significantly lower than those of untreated bone in control rats (P < 0.05). There was no marked difference between these parameters of Al-treated bone in control rats and untreated bone in PTX rats (P > 0.05), and these of Al-treated bone in PTX rats were the lowest (P > 0.05- < 0.05). Ca contents were consistent with the histological parameters. Bone Al removing rate between PTX and control rats was not markedly different. In conclusion, both PTX and Al impair bone formation and mineralization, bone biopsy and removal of Al from bone is necessary before PTX treatment in uremic patients with secondary hyperparathyroidism.
Zhu
J M
JM
Renal Research Laboratory, Second Affiliated Hospital, Xi'an Medical University.
Alfrey
A C
AC
Huffer
W E
WE
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001847:Bone Diseases / Q000139:chemically induced*; D001857:Bone Matrix; D001842:Bone and Bones / Q000378:metabolism; D008297:Male; D016105:Parathyroidectomy; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley
D000535:Aluminum