title: Varicella-zoster virus (VZV) reactivation is related to the low response of VZV-specific immunity after chickenpox in infancy.
abstract: To clarify the cause of herpes zoster in immunocompetent children, specific humoral and cellular immunity was determined using an ELISA and a lymphoproliferative assay, respectively, in infants < 1 year of age and children > or = 1 year of age who had chickenpox. Thirteen (59.1%) of 22 infants, 17 (81.0%) of 21 children > or = 1 year of age (P < .02), and 13 (86.7%) of 15 children > or = 2 years of age (P < .001) had positive varicella-zoster virus (VZV)-specific cellular immunity. VZV-specific antibodies in infants were significantly lower than those in children > or = 1 year old (P < .01) and > or = 2 years old (P < .001). The possibility of subclinical reactivation was demonstrated by an increase in the specific cellular or humoral immunity (or both) in all of 6 infants who had negative specific cellular immunity. The low response of specific immunity and the immunologic evidence of reactivation in infants after chickenpox provide a possible explanation for the finding that chickenpox in infancy is a risk factor for herpes zoster.
authors.affiliation: Department of Pediatrics, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Terada
authors.forename: S
authors.initials: S
authors.lastname: Kawano
authors.forename: K
authors.initials: K
authors.lastname: Yoshihiro
authors.forename: T
authors.initials: T
authors.lastname: Morita
mesh_terms: D000917:Antibody Formation; D002644:Chickenpox / Q000276:immunology* / Q000382:microbiology; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D014645:Herpesvirus 3, Human / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D014775:Virus Activation