Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?
Immune responses to bacterial antigens that appear unrestricted by the MHC may involve oligomorphic MHC class Ib molecules. One example is H-2M3, which binds N-formylated peptides and presents a Listeria peptide to cytotoxic T cells from infected mice. Lack of polymorphism makes these molecules a promising target for peptide vaccines.
Pamer
E G
EG
Infectious Disease Section, Yale University School of Medicine, New Haven, CT 06510-8056.
Bevan
M J
MJ
Lindahl
K F
KF
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D008089:Listeria monocytogenes / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000942:Antigens, Bacterial; D015395:Histocompatibility Antigens Class I; D011948:Receptors, Antigen, T-Cell