title: Cellular and subcellular alterations of the thyroid gland in rats caused by lithium carbonate.
abstract: Biochemical, hematologic, histometric, structural and ultrastructural changes were studied in the thyroid gland of rats, whom were administered Lithium carbonate. It was noted that (1) the Li carbonate had a cumulative effect on the serum; (2) T3 and T4 hormones in the blood decreased throughout the experiment; (3) the red blood cells, hemoglobin, hematocrit, platelets and leukocytes decreased gradually; (4) the diameter of the thyroid follicles, the size of the follicular cells and colloid droplets decreased, whereas the stroma was invaded by a greater number of collagen fibers and blood capillaries.
authors.affiliation: Faculty of Medicine of Santo Amaro, Brazil.
authors.forename: F C
authors.initials: FC
authors.lastname: Valle
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: J C
authors.initials: JC
authors.lastname: Prates
authors.forename: L J
authors.initials: LJ
authors.lastname: Didio
mesh_terms: D000818:Animals; D004906:Erythrocyte Count / Q000187:drug effects; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D016651:Lithium Carbonate / Q000494:pharmacology*; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D006454:Hemoglobins; D014284:Triiodothyronine; D016651:Lithium Carbonate; D013974:Thyroxine