Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control.
The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.
Zhang
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MRC Tuberculosis and Related Infections Unit, RPMS, Hammersmith Hospital, London, UK.
Young
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DB
D000818:Animals; D001426:Bacterial Proteins; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity; D010544:Peroxidases / Q000235:genetics / Q000502:physiology; D014774:Virulence
D001426:Bacterial Proteins; D010544:Peroxidases; C076136:catalase HPI; D007538:Isoniazid