[The dependence of the effects of naloxone on the type of nociceptive stimulus].
The dynamics of latent periods of the tail-flick reaction in response to thermal nociceptive stimulus (TNS) and electrocutaneous nociceptive stimulus (ENS) was studied in Wistar rats. Naloxone, 1.4 and 2.8 mg/kg, intraperitoneally injected evoked analgesia in response to TNS and hyperalgesia in response to ENS. It is suggested that the bidirectional effects of naloxone are associated with the specificity of nociceptive mechanisms activated by different pain stimuli.
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation / Q000009:adverse effects; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D009270:Naloxone / Q000008:administration & dosage*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
D009270:Naloxone
Zavisimost' éffektov naloksona ot vida notsitseptivnogo stimula.