The genomic synteny at DNA level between human and chimpanzee chromosomes.
The evolutionary relationship between human (Homo sapiens) and chimpanzee (Pan troglodytes) has been the subject of debate and scrutiny for over two decades. The close relationship established by numerous parameters may or may not reflect homology at the DNA level. The recent advent of a molecular method termed the chromosome in situ suppression hybridization (CISS)-technique has prompted us to explore the phylogenetic relationship at the DNA sequence level. Cross-hybridization data using human-derived whole chromosome paints (WCPs) suggests an apparent genomic synteny with chimpanzee chromosomes at the DNA level, thus providing a better understanding of an evolutionary relationship between humans and chimpanzees.
Luke
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Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201.
Verma
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D000818:Animals; D005075:Biological Evolution; D004247:DNA / Q000235:genetics*; D015342:DNA Probes; D016678:Genome; D015894:Genome, Human; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D002679:Pan troglodytes / Q000235:genetics*; D010802:Phylogeny; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D015342:DNA Probes; D004247:DNA