Study of anticancer drug interaction with DNA by means of particle-induced desorption mass spectrometry: prospydine and deoxyguanosine-5'-monophosphate.
Using 252CF particle desorption mass spectrometry, the interaction between an antitumour drug prospydine (Pro) and deoxyguanosine-5'-monophosphate (pdG) has been studied. The adduct which corresponds to a peak at m/z 524.5 and which occurs as a result of the particular degradation of Pro during its alkylating of pdG has been found.
Sukhodub
L F
LF
Institute of Applied Physics, Academy of Sciences of Ukraine, Sumy.
Grebenik
L I
LI
Chivanov
V D
VD
D000970:Antineoplastic Agents / Q000737:chemistry*; D002142:Californium; D004247:DNA / Q000737:chemistry*; D003848:Deoxyguanine Nucleotides / Q000737:chemistry*; D013058:Mass Spectrometry; D011447:Prospidium / Q000737:chemistry*
D000970:Antineoplastic Agents; D003848:Deoxyguanine Nucleotides; C007257:2'-deoxyguanosine 5'-phosphate; D011447:Prospidium; D004247:DNA; D002142:Californium