title: Cardiorespiratory effects of conventional and high frequency ventilation in rabbits with bilateral pneumothoraces and surfactant depleted lungs.
abstract: We compared high frequency ventilation (HFV) to conventional mechanical ventilation (CMV) under normoxic and normocapnic condition in surfactant depleted rabbits with bilateral pneumothoraces. We hypothesized that lower airway pressures would be required with HFV under these conditions. We applied CMV and HFV in 8 anaesthetized rabbits with a prototype ventilator at frequencies of 30, 100, 200, and 300 cycles/min. A positive end-expiratory pressure (PEEP) just below the pressure sufficient to open the air leak from the pneumothoraces was applied at all frequencies. Airway pressures, gas exchange, heart rate, and mean arterial pressure were recorded. Peak airway pressure decreased significantly from 2.50 to 2.10 kPa when the frequency of ventilation was increased from 30 to 300 cycles/min. There were no significant changes in mean airway pressure, PaO2, arterial pH, heart rate, and mean arterial pressure when HFV was compared to CMV. In conclusion, during HFV peak airway pressures measured at the mouth were decreased. Our ability to maintain adequate gas exchange in the face of ongoing pulmonary air leaks may reflect lower alveolar pressures.
authors.affiliation: Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: M E
authors.initials: ME
authors.lastname: Nicol
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
authors.forename: A
authors.initials: A
authors.lastname: Holdcroft
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006612:High-Frequency Ventilation; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D011030:Pneumothorax / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D011175:Positive-Pressure Respiration; D011312:Pressure; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000172:deficiency; D011817:Rabbits; D012121:Respiration, Artificial
chemical_list: D011663:Pulmonary Surfactants