[Cyclic adenosine monophosphate metabolism in the peripheral blood lymphocytes of atopic patients exposed to histamine].
Radioisotopic assay has shown that in vitro histamine increases the metabolism of cyclic adenosine monophosphate (cAMP) through H-2 receptors in the peripheral blood lymphocytes of healthy individuals and patients with atopic bronchial asthma. In patients who have asphyxia the histamine-induced stimulation of the activity of cAMP phosphodiesterase metabolizing cAMP is considerably decreased. In is suggested that high cAMP metabolism may be a cause of desensitization of histaminic and adrenergic receptors in atopy whose aggravation is accompanied by histaminemia.
Kotova
S A
SA
Berezhnaia
N M
NM
Belova
O B
OB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000187:drug effects / Q000378:metabolism; D001249:Asthma / Q000097:blood; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002927:Cimetidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000097:blood*; D004155:Diphenhydramine / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*
D002927:Cimetidine; D006632:Histamine; D004155:Diphenhydramine; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Metabolizm tsiklicheskogo adenozinmonofosfata v limfotsitakh perifericheskoĭ krovi bol'nykh atopieĭ pri vozdeĭstvii gistamina.