title: [The use of Enduracin--a prolonged-action form of nicotinic acid--in correcting atherogenic dyslipidemias].
abstract: The hypolipidemic effects of induracin, a new long-acting nicotinic acid dosage form based on the waxy matrix, and its tolerance were studied in 31 patients with Types IIa and IIb hyperlipoproteinemias in a 6-month blind crossover study. There were decreases in the levels of total cholesterol by 9-13% and low density lipoprotein cholesterol by 12-22%, an increase in high density lipoprotein cholesterol by 12-15%, and a good dynamics in the ratio of blood lipid-transport proteins--a 12-16% increase to the levels of apoprotein AI to a 29% decrease in those of apoprotein B. The drug is well tolerated by patients and may be recommended for correction of atherogenic dyslipidemias.
authors.forename: R G
authors.initials: RG
authors.lastname: Oganov
authors.forename: N G
authors.initials: NG
authors.lastname: Kiseleva
authors.forename: D M
authors.initials: DM
authors.lastname: Aronov
authors.forename: N M
authors.initials: NM
authors.lastname: Akhmedzhanov
authors.forename: A M
authors.initials: AM
authors.lastname: Olfer'ev
authors.forename: N S
authors.initials: NS
authors.lastname: Kiseleva
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D000960:Hypolipidemic Agents; D008055:Lipids; D008074:Lipoproteins; D009525:Niacin
vernacular_title: Primenenie enduratsina--prolongirovannoĭ formy nikotinovoĭ kisloty--v korrektsii aterogennykh dislipidemiĭ.