Anti-inflammatory active polyacetylenes from Bidens campylotheca.
The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E,10E,16-tetraene-4,6-diyne (1), heptadeca-2E,8Z,10E,16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new compound, safynol-2-O-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.
Redl
K
K
Institut für Pharmazeutische Biologie, Universität München, Federal Republic of Germany.
Breu
W
W
Davis
B
B
Bauer
R
R
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006254:Hawaii; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053279:Polyynes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011108:Polymers; D053279:Polyynes; D000114:Acetylene