[Lipids metabolism evaluated of by vitamin E to total lipid ratio in maternal and cord sera in normal pregnancy].
Changes in plasma levels of lipids peroxide (LPO) and vitamin E(VE) are observed in pregnant women. We measured levels of VE and lipids in 80 maternal and cord sera in normal delivery and obtained the following results. 1. For each lipid and VE, the concentration gradients were preserved in maternal sera to cord sera through placentas. 2. The concentration of VE correlated with that of total lipids (TL) in both sera. 3. The VE to TL ratio (VE/TL ratio) inversely correlated with the concentration of LPO in both sera. 4. The concentration of VE correlated with the VE/TL ratio and there was a more significant correlation of the VE and VE/TL ratio than that of VE and TL in both sera. 5. The VE/TL ratio in maternal serum correlated with VE/TL ratio and the concentration of VE in cord serum. These results suggested that lipids in serum was a regulatory factor in VE and that VE and lipids maintained the gradation of the concentration according to their own placental transport systems. It seems that the fetus has a unique VE which is comparatively lowered. This may be due to the effects of the accelerated lipid metabolism in the fetus.
Mizumoto
Y
Y
Department of Obstetrics and Gynecology, SDF Central Hospital, Tokyo.
Okuyama
T
T
Horie
M
M
Endo
R
R
Tenmyo
M
M
Ogura
H
H
Abe
M
M
D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D008054:Lipid Peroxides; D014810:Vitamin E