[The enzymatic and electrocardiographic changes falsely indicative of an acute myocardial infarct during hypothyroidism].
Estimation of the enzymes CPK and LDH, with their isoenzymes, is useful in diagnosing myocardial infarction and monitoring its progress. However, increases of CPK-MB and LDH1, may be not associated with acute myocardial infarction, as in hypothyroidism, muscular dystrophy, polymyositis, malignant disease. We report a case of hypothyroidism with increased CPK-MB and LDH1. At the beginning the diagnosis was difficult because of altered electrocardiogram associated with one event of "burning" localized altered at the anterior thorax. This case illustrates that plasma enzyme activity and isoenzyme profiles should be interpreted with caution when clinical and instrumental (eco 2D) findings are not entirely associated with myocardial infarction.
Minutiello
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Divisione di Cardiologia, Presidio Ospedaliero di Camerino, Regione Marche, USL 20, Marcerata.
D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D004452:Echocardiography; D004562:Electrocardiography; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D013960:Thyroid Function Tests
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
Alterazioni enzimatiche ed elettrocardiografiche falsamente indicative di infarto miocardico acuto in corso di ipotiroidismo.