The association between 'faint-positive' amniotic fluid acetylcholinesterase and fetal malformations.
The finding of a 'faint-positive' acetylcholinesterase band in amniotic fluid samples of women at 15 weeks' gestation or above is associated with an increased risk of fetal abnormalities, most commonly gastroschisis. This finding warrants a targeted sonographic evaluation, in order to rule out significant fetal malformations.
Sadovsky
Y
Y
Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco.
Robbin
M L
ML
Crandall
B F
BF
Filly
R A
RA
Golbus
M S
MS
D000110:Acetylcholinesterase / Q000032:analysis*; D000653:Amniotic Fluid / Q000201:enzymology*; D000013:Congenital Abnormalities / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D012307:Risk Factors
D000110:Acetylcholinesterase