title: Long-term oral administration of aluminum in mice. Aluminum distribution in tissues and effects on calcium metabolism.
abstract: Six months of oral administration of aluminum lactate provokes an important accumulation of aluminum in various tissues of mice. The accumulation magnitude order is spleen > kidney > brain > liver > blood. No systemic toxic effects (weight loss or neurolytic effects) were observed. Values of calcium content and 45Ca-uptake by the different tissues showed no modifications of calcium metabolism. The lack of calcium homeostasis modification caused by a probable aluminum insolubilization, and the incidence of other individual factors on individual deviations from group behavior is discussed.
authors.affiliation: Biophysics Laboratory, Medicine Faculty, University of Nancy, France.
authors.forename: L J
authors.initials: LJ
authors.lastname: Anghileri
authors.forename: P
authors.initials: P
authors.lastname: Maincent
authors.forename: P
authors.initials: P
authors.lastname: Thouvenot
mesh_terms: D000535:Aluminum / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D005260:Female; D006706:Homeostasis; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D002132:Calcium Radioisotopes; D000535:Aluminum; D002118:Calcium