title: [Gamete donation in an in vitro fertilization program].
abstract: Two cases of gamete donation in an IVF program were reported in this paper. In the first case the wife with recurrent abortions was found to have chromosomal abnormality, her karyotype was 45,XX,-14,-14 + rob (14 Q 14 Q). She became pregnant after IVF-ET with donated ova, and was delivered of a normal male baby on June 12, 1992. The baby's karyotype was normal. The blood group of both the husband and wife was O, while that of the baby was B. The baby suffered from icterus neonatorum as a result of ABO incompatibility but recovered quickly after treatment. Further DNA finger print analysis of the husband, wife and baby, combined with the history of egg donation IVF, proved the relationship of the parents with the baby. In the second case the husband's karyotype was 46,XY, t(4; 9) (4Q+; 9Q-). The wife had also history of recurrent abortions. Since 1989, the wife received sperm donation IUI 5 times in another hospital without success. IVF-ET with donated sperms was performed in November 1991 resulting in clinical pregnancy. She was delivered of a pair of twins, one male and one female on July 20, 1992. The possibilities of different types of gamete formation during meiosis in carriers of chromosomal balanced translocation were briefly discussed. Donation of oocytes could be realized only in an IVF program, which is also the only way to propagate for the family. However, IVF with donated sperms is indicated in women with blocked tubes besides the male factor or after repeated failures of other assisted reproductive technologies.
authors.affiliation: Third Affiliated Hospital, Beijing Medical University.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007316:Insemination, Artificial, Heterologous; D008297:Male; D009865:Oocytes; D011247:Pregnancy; D011256:Pregnancy Outcome; D013094:Spermatozoa; D014019:Tissue Donors