title: Elevated levels of interleukin-8 and leukotriene B4 in pulmonary edema fluid of a patient with reexpansion pulmonary edema.
abstract: We experienced a case of reexpansion pulmonary edema (RPE) after surgical treatment of pneumothorax. In this case, protein leakage and polymorphonuclear leukocyte (PMN) accumulation were observed in the reexpanded lung. Interleukin-8 and leukotriene B4 in edema fluid were increased at the onset of RPE. PMN elastase was also increased, though its peak was delayed. The plasma level of P-selectin, which mediates adhesion between PMN and endothelium, was elevated. We speculate that some of these fluid mediators may play important roles in chemotaxis and activation of PMN in the development of RPE.
authors.affiliation: Department of Medicine and Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Ishizaka
authors.forename: M
authors.initials: M
authors.lastname: Sawafuji
authors.forename: T
authors.initials: T
authors.lastname: Urano
authors.forename: S
authors.initials: S
authors.lastname: Fujishima
authors.forename: F
authors.initials: F
authors.lastname: Sakamaki
authors.forename: K
authors.initials: K
authors.lastname: Sayama
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: R
authors.initials: R
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D015633:Extravascular Lung Water / Q000737:chemistry*; D005122:Exudates and Transudates / Q000737:chemistry; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D007975:Leukotriene B4 / Q000032:analysis*; D008297:Male; D011030:Pneumothorax / Q000150:complications / Q000378:metabolism / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism*; D011654:Pulmonary Edema / Q000209:etiology / Q000378:metabolism*; D013997:Time Factors
chemical_list: D016209:Interleukin-8; D007975:Leukotriene B4