title: [The central vascular and metabolic effects of pyroglutamic acid].
abstract: The ability of pyroglutamic acid, a cyclic glutamic acid derivative, to increase cerebral blood flow, to decrease the resistance of brain vessels, and to relax the isolated grafts of cerebral arteries has been demonstrated. Pyroglutamic acid markedly stimulated brain metabolism: increased glucose uptake and utilization by cerebral tissues and decreased brain lactate dehydrogenase activity.
authors.forename: S A
authors.initials: SA
authors.lastname: Mirzoian
authors.forename: M G
authors.initials: MG
authors.lastname: Zalinian
authors.forename: M G
authors.initials: MG
authors.lastname: Balasanian
authors.forename: A V
authors.initials: AV
authors.lastname: Topchian
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects* / Q000378:metabolism*; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002250:Carbon Radioisotopes; D012701:Serotonin; D007770:L-Lactate Dehydrogenase; D005947:Glucose; D011761:Pyrrolidonecarboxylic Acid
vernacular_title: Tsentral'nye sosudistye i metabolicheskie éffekty piroglutaminovoĭ kisloty.