title: Carbonic anhydrase activators. VII. Isozyme II activation by bisazolyl-methanes, -ethanes and related azoles.
abstract: A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
authors.affiliation: University of Bucharest, Department of Chemistry, Roumania.
authors.forename: C T
authors.initials: CT
authors.lastname: Supuran
authors.forename: A T
authors.initials: AT
authors.lastname: Balaban
authors.forename: P
authors.initials: P
authors.lastname: Cabildo
authors.forename: R M
authors.initials: RM
authors.lastname: Claramunt
authors.forename: J L
authors.initials: JL
authors.lastname: Lavandera
authors.forename: J
authors.initials: J
authors.lastname: Elguero
mesh_terms: D001393:Azoles / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004789:Enzyme Activation; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics
chemical_list: D001393:Azoles; D007527:Isoenzymes; D002256:Carbonic Anhydrases