Murine experimental autoimmune uveoretinitis induced by interphotoreceptor retinoid-binding protein and Klebsiella pneumoniae 03 lipopolysaccharide (K03-LPS): a relation between H-2 haplotype and EAU induction.
The pathogenicity of interphotoreceptor retinoid-binding protein (IRBP) in the mouse and H-2 restriction of IRBP-induced experimental autoimmune uveoretinitis (EAU) was tested by repeated immunization using Klebsiella pneumoniae 03 lipopolysaccharide (K03-LPS) as an adjuvant. It was shown that IRBP had a greater capacity to induce EAU than S-antigen. Based on the incidence of EAU induction using B10 congenic mice and other strains, the susceptibility to EAU was, at least in part, controlled by the I-Ak haplotype of the H-2 subregion. The results also indicated that non-major histocompatibility complex (MHC) genes play some role in disease susceptibility.
Ando
K
K
Department of Ophthalmology, Tokyo University School of Medicine, Japan.
Yamamoto
J H
JH
Fujino
Y
Y
Kato
N
N
Mochizuki
M
M
D000818:Animals; D000941:Antigens; D019393:Arrestin; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D005136:Eye Proteins; D006183:H-2 Antigens / Q000276:immunology*; D006239:Haplotypes; D015994:Incidence; D007711:Klebsiella pneumoniae; D008070:Lipopolysaccharides; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D012173:Retinitis / Q000276:immunology* / Q000473:pathology; D012177:Retinol-Binding Proteins / Q000276:immunology; D015866:Uveitis, Posterior / Q000276:immunology* / Q000473:pathology; D000099214:Retinol-Binding Proteins, Interstitial
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D006183:H-2 Antigens; D008070:Lipopolysaccharides; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial; C043237:Klebsiella O3 lipopolysaccharide