title: Quantitative EEG correlates of cognitive deterioration in the elderly.
abstract: We report on the quantitative analysis of the EEG (QEEG), using the Neurometric method, in large samples of normal elderly; normal subjectively impaired elderly; patients with mild cognitive impairment; patients presenting with a continuum of primary cognitive deterioration from mild to moderately severe as measured by the Global Deterioration Scale (GDS), compatible with dementia of the Alzheimer's type (DAT). Neurometric QEEG measures were found to be a sensitive index of degree of cognitive impairment, especially reflected in increased absolute and relative power in the theta band, with delta increasing in later stages of deterioration. While these abnormalities were widespread, neither localized or lateralized, MANOVA's for GDS and relative power in theta reached highest significance in a bilateral temporo-parietal arc. A possible relationship between hippocampal dysfunction, cognitive deterioration, and theta abnormalities is discussed in relation to these findings. The results suggest that Neurometric QEEG features are sensitive to the earliest presence of subjective cognitive dysfunction and might be useful in the initial evaluation of patients with suspected dementia, as well as in estimating the degree of cognitive deterioration in DAT patients.
authors.affiliation: Department of Psychiatry, New York University Medical Center, NY 10016.
authors.forename: L S
authors.initials: LS
authors.lastname: Prichep
authors.forename: E R
authors.initials: ER
authors.lastname: John
authors.forename: S H
authors.initials: SH
authors.lastname: Ferris
authors.forename: B
authors.initials: B
authors.lastname: Reisberg
authors.forename: M
authors.initials: M
authors.lastname: Almas
authors.forename: K
authors.initials: K
authors.lastname: Alper
authors.forename: R
authors.initials: R
authors.lastname: Cancro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology / Q000523:psychology; D001931:Brain Mapping; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged