title: New cycloartanol sulfates from the alga Tydemania expeditionis: inhibitors of the protein tyrosine kinase pp60v-src.
abstract: Bioactivity-directed fractionation of the extracts of the green alga Tydemania expeditionis using the protein tyrosine kinase pp60v-src led to the isolation of three new cycloartanol disulfates, 1-3, which show modest inhibition of this enzyme. The structures were deduced by spectroscopic methods.
authors.affiliation: Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019.
authors.forename: M
authors.initials: M
authors.lastname: Govindan
authors.forename: S A
authors.initials: SA
authors.lastname: Abbas
authors.forename: F J
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: R H
authors.initials: RH
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Papkoff
authors.forename: D L
authors.initials: DL
authors.lastname: Slate
mesh_terms: D001358:Avian Sarcoma Viruses / Q000201:enzymology; D002478:Cells, Cultured; D000460:Chlorophyta / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015688:Oncogene Protein pp60(v-src) / Q000037:antagonists & inhibitors*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes
chemical_list: D010840:Phytosterols; D014315:Triterpenes; D015688:Oncogene Protein pp60(v-src); C100089:cycloartenol