The influence of thyroxine and propyl thiouracil on Parastrongylus malaysiensis infection in rats.
Daily intramuscular injection with thyroxine (T4) at a dose of 2.5 micrograms/100 g body weight decreased the larvae and adult worm burden of Parastrongylus malaysiensis in the brain and pulmonary arteries of male Sprague-Dawley albino rats. In contrast, rats treated with propyl thiouracil (PTU), an antithyroid drug, at a dose of 3.75 mg/100 g body weight retained greater numbers of larvae and adult worms. The results may reflect the contrasting immunomodulatory effects of T4 and PTU that influence the susceptibility of the host.
Kamis
A B
AB
Jabatan Zoologi, Universiti Kebangsaan Malaysia, Bangi.
Ahmad
R A
RA
Chang
J S
JS
Ambu
S
S
D000801:Angiostrongylus; D000818:Animals; D001921:Brain / Q000469:parasitology; D007107:Immune System / Q000187:drug effects; D008168:Lung / Q000469:parasitology; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017206:Strongylida Infections / Q000209:etiology* / Q000276:immunology / Q000469:parasitology; D013974:Thyroxine / Q000494:pharmacology*
D011441:Propylthiouracil; D013974:Thyroxine