[The effects of opioid peptides on postsynaptic potentials in slice preparation of nucleus accumbens of rats].
Behavioral studies indicate that nucleus accumbens (NAcc) is a key brain area for the rewarding effects of opiate and for opiate addiction. To find out the cellular correlates of opiate addiction, the effects of three kinds of opiate peptides on membrane potential and postsynaptic potentials (PSPs) in a slice preparation of NAcc were studies by intracellular recording and current-clamp technique. The results indicated that superfusion of opioid 7 peptides did not affect membrane potential and input resistance of NAcc neurons, but significantly reduced postsynaptic potentials. Naloxone superfusion significantly reversed the depressant effects of mu and sigma receptor agonist (DAGO, D-Pen) on PSPs, but not on those of kappa agonist (U-50). These results suggest that opioid peptides predominantly reduce synaptic transmission in NAcc.
Yuan
X R
XR
Department of Physiology, Nanjing Medical College.
Madamba
S
S
Siggins
G R
GR
D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D009293:Opioid-Related Disorders; D051381:Rats; D017207:Rats, Sprague-Dawley; D011957:Receptors, Opioid / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D004723:Endorphins; D011957:Receptors, Opioid