title: Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.
abstract: We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI). Clinical manifestations including vomiting, diarrhoea and dyspnoea were identical in both cases. Biological data mainly revealed hepatic failure and lactic acidosis. Histological examination of liver biopsies showed diffuse microvesicular steatosis. The outcome was fatal in both patients. The only comparable case previously reported (Lai et al., 1991) showed close similarities in the clinical, biological and histological manifestations with microvesicular steatosis. This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients. This toxic effect may be added to the list of potential adverse events occurring during ddI therapy.
authors.affiliation: Hepato-gastroenterology Second AIDS Unit, Hôtel-Dieu Hospital, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Bissuel
authors.forename: F
authors.initials: F
authors.lastname: Bruneel
authors.forename: F
authors.initials: F
authors.lastname: Habersetzer
authors.forename: D
authors.initials: D
authors.lastname: Chassard
authors.forename: L
authors.initials: L
authors.lastname: Cotte
authors.forename: M
authors.initials: M
authors.lastname: Chevallier
authors.forename: J
authors.initials: J
authors.lastname: Bernuau
authors.forename: J C
authors.initials: JC
authors.lastname: Lucet
authors.forename: C
authors.initials: C
authors.lastname: Trepo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000140:Acidosis, Lactic / Q000139:chemically induced*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000368:Aged; D016049:Didanosine / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D006501:Hepatic Encephalopathy / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016049:Didanosine