[Isolated lung transplantation. Analysis of 17 consecutive operations. Munich Lung Transplant Group].
16 patients (nine men, seven women; mean age 45 [23-62] years) with end-stage pulmonary disease underwent lung transplantation, 14 unilateral, three bilateral (one bilateral retransplantation). The diagnoses were: emphysema (n = 5), idiopathic pulmonary fibrosis (n = 5), emphysema in alpha 1-antitrypsin deficiency (n = 1), mucoviscidosis (n = 1), drug-induced fibrosis (n = 1), chronic lung rejection after heart-lung transplantation (n = 1), secondary pulmonary hypertension with persistent ductus arteriosus (n = 1), sarcoidosis (n = 1) and chronic transplant failure after unilateral transplantation (n = 1). Eleven patients survived long-term (mean follow-up period 247 [8-585] days). Ten of these patients have been independent of additional oxygen after an average of 8 months postoperatively, eight are physically active according to their age. Three patients died of reperfusion damage intraoperatively or in the early postoperative period. The two other patients died from septicaemia 5 1/2 and 7 months postoperatively. It is concluded that lung transplantation in end-stage pulmonary disease provides the only therapeutic means with any expectation of physical rehabilitation.
Dienemann
H
H
Chirurgische Klinik und Poliklinik, Universität München.
Reichenspurner
H
H
Forst
H
H
Reichart
B
B
D000203:Activities of Daily Living; D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011788:Quality of Life; D012086:Reoperation; D012129:Respiratory Function Tests; D016019:Survival Analysis
D007166:Immunosuppressive Agents
Isolierte Lungentransplantation. Analyse von 17 konsekutiven Operationen. Munich Lung Transplant Group.