title: Topical glucocorticoid has no antinociceptive or anti-inflammatory effect in thermal injury.
abstract: We have studied the antinociceptive and anti-inflammatory effects of topical glucocorticoids in human thermal injury. The right and left legs of 12 healthy volunteers were allocated randomly to be treated with either 0.05% clobetasol propionate cream or placebo in a double-blind trial. Thermal injuries were induced with a thermode, which was heated to 49 degrees C for 5 min under standardized pressure. Clobetasol propionate or placebo cream was applied to the skin 1 h before burn injury, immediately after the injury and every 12 h for the next 3 days. Heat pain detection thresholds (HPDT), heat pain tolerance (HPT), mechanical pain detection thresholds (MPDT) and the intensity of burn-induced erythema (erythema index, EI) were assessed inside the thermal injury and areas of hyperalgesia to pinprick outside the injury were determined before and regularly for 72 h after the burn injury. Burn injury caused a decrease in HPDT, HPT and MPDT, an increase in EI and development of mechanical, secondary hyperalgesia. Clobetasol propionate had no effect on any of the nociceptive or inflammatory variables studied.
authors.affiliation: Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: J L
authors.initials: JL
authors.lastname: Pedersen
authors.forename: S
authors.initials: S
authors.lastname: Møiniche
authors.forename: H
authors.initials: H
authors.lastname: Kehlet
mesh_terms: D000328:Adult; D002056:Burns / Q000188:drug therapy*; D002990:Clobetasol / Q000627:therapeutic use*; D004311:Double-Blind Method; D004890:Erythema / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D012867:Skin / Q000293:injuries; D013997:Time Factors
chemical_list: D002990:Clobetasol