Experimental study of the internal signal of alliesthesia induced by sweet molecules in rats.
To identify the preabsorptive signal that arouses alliesthesia, we compared the effects of five sweet molecules: glucose (3 g.5 ml-1), cyclamate (0.280 g.5 ml-1), saccharin (0.016 g.5 ml-1), aspartame (0.020 g.5 ml-1), and mannitol (3 g.5 ml-1) on the intestive aversive responses of rats. In Experiment 1, the sweet stimuli were adjusted to taste similarly sweet, and they were administered orally; they aroused similar ingestive responses. In Experiment 2, an isovolumetric load of each of the five molecules was administered in the stomach and its influence on ingestive/aversive response aroused by oral sucrose was recorded. Negative alliesthesia was obtained after gastric loads of glucose and mannitol, but not after gastric loads of cyclamate, saccharin, and aspartame.
Zhao
C
C
Département de Physiologie, Faculté de Médicine, Université Laval, Québec, Canada.
Cabanac
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M
D000284:Administration, Oral; D000818:Animals; D002149:Energy Intake / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D009042:Motivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012528:Satiety Response / Q000187:drug effects*; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*
D013549:Sweetening Agents; D013395:Sucrose