Hypothermia decreases astroglial injury and arachidonate release during combined glucose-oxygen deprivation.
Hypothermia provides significant protection when initiated during or after cerebral ischemia in vivo. However, the mechanisms producing this protective effect are not known. Astroglial cultures were prelabeled with [3H]arachidonic acid. Hypothermia reduced both cellular injury and release of [3H]-labeled arachidonic acid metabolites during combined glucose-oxygen deprivation. Inhibition of phospholipid degradation may be one of the mechanisms that contributes to the protective effect of hypothermia.
Haun
S E
SE
Department of Pediatrics, Ohio State University, Columbus 43210.
Trapp
V L
VL
Horrocks
L A
LA
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism / Q000502:physiology*; D002478:Cells, Cultured; D003080:Cold Temperature; D005947:Glucose / Q000502:physiology*; D002534:Hypoxia, Brain / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D010743:Phospholipids; D016718:Arachidonic Acid; D005947:Glucose