title: High-fructose diet does not raise 24-hour mean arterial pressure in rats.
abstract: High intakes of the simple sugars--glucose, sucrose, and fructose--have been reported to raise significantly systolic pressure in rats. It is not clear, however, if under those conditions the acute measurement of blood pressure, especially with the tail-cuff technique, represents accurately the effect of the diet on mean arterial pressure throughout the day. In this study, 15 Sprague-Dawley rats (approximately 325 g) were chronically instrumented with arterial and venous catheters and placed on a diet containing 61% vegetable starch and 5% dextrose; seven rats remained on this diet throughout the study. After 4 days of control measurements, eight rats were switched to a diet that substituted 66% fructose for the vegetable starch and dextrose. Mean arterial pressure (MAP) was measured 20 h/day by computerized methods. MAP during the 4 control days averaged 100 +/- 3 and 105 +/- 3 mm Hg in low-fructose (LF) and high-fructose (HF) diet rats, respectively. Switching to the HF diet caused no change in MAP, and after 11 days MAP averaged 104 +/- 2 and 108 +/- 3 mm Hg in the LF and HF rats, respectively. In addition, the variability of MAP over the 20-h period each day was not altered by the HF diet, and raising sodium intake fourfold caused a similar rise in MAP in both groups. There also were no significant changes in plasma glucose or insulin concentrations. Thus, a change in dietary simple sugar content from 5% dextrose to 66% fructose did not change MAP or alter blood pressure variability or sodium sensitivity.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
authors.forename: M W
authors.initials: MW
authors.lastname: Brands
authors.forename: C A
authors.initials: CA
authors.lastname: Garrity
authors.forename: M G
authors.initials: MG
authors.lastname: Holman
authors.forename: H L
authors.initials: HL
authors.lastname: Keen
authors.forename: M
authors.initials: M
authors.lastname: Alonso-Galicia
authors.forename: J E
authors.initials: JE
authors.lastname: Hall
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005632:Fructose / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004040:Dietary Carbohydrates; D005632:Fructose