title: Relationship between striatal glucose consumption and copper excretion in patients with Wilson's disease treated with D-penicillamine.
abstract: In 12 patients with Wilson's disease treated with D-penicillamine (DPA), the regional cerebral metabolic rate of glucose consumption of the lentiform and caudate nucleus was analysed using the 18Fluorodeoxyglucose method and correlated with the clinical symptoms of the patients, the ceruloplasmin level, the serum level of free copper and the 24-h copper excretion. The more copper was eliminated, the higher was the basal ganglia glucose consumption. On the other hand, in seven patients who had been treated for more than 7 years a significant decline of the basal ganglia glucose consumption was observed, suggesting too low a maintenance dose of DPA.
authors.affiliation: Neurologische Universitätsklinik, Düsseldorf, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hefter
authors.forename: T
authors.initials: T
authors.lastname: Kuwert
authors.forename: H
authors.initials: H
authors.lastname: Herzog
authors.forename: G
authors.initials: G
authors.lastname: Arendt
authors.forename: W
authors.initials: W
authors.lastname: Stremmel
authors.forename: L E
authors.initials: LE
authors.lastname: Feinendegen
mesh_terms: D000293:Adolescent; D000328:Adult; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000652:urine*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006527:Hepatolenticular Degeneration / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003300:Copper; D003847:Deoxyglucose; D002570:Ceruloplasmin; D010396:Penicillamine; D005947:Glucose