Aberrations of chromosome 22 and polysomy of chromosome 8 as non-random changes in clear cell sarcoma.
Cytogenetic analysis was performed on a primary tumor and a metastatic lesion of a clear cell sarcoma of tendons and aponeuroses (CCS), a rare soft tissue neoplasm of uncertain histopathologic origin. Clonal chromosomal abnormalities resulting in two related clones were found in both tumors. The karyotype was near-triploid with several structural and numerical changes, comprising a der(15;22) (q10;q10). Including the present case, 14 of 15 cases of CCS have had structural or numerical aberrations of chromosome 22 and nine of them (65%) displayed a similar or identical t(12;22)(q13-14;q12-13). Our findings suggest that in the absence of specific t(12;22), other abnormalities of chromosome 22 may be significant. In addition, increased doses of chromosome 8 found in 70% of the tumors strongly suggest a significant role for this chromosome in the development of clear cell sarcoma.
Limon
J
J
Department of Biology and Genetics, Medical Academy Gdańsk, Poland.
Debiec-Rychter
M
M
Nedoszytko
B
B
Liberski
P P
PP
Babińska
M
M
Szadowska
A
A
D000328:Adult; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D018227:Sarcoma, Clear Cell / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*