title: Rapidly fatal necrotising fasciitis caused by Streptococcus pyogenes.
abstract: OBJECTIVE
  To describe the morbid anatomical and bacteriological features in a series of five cases of rapidly fatal Streptococcus pyogenes necrotising fasciitis.
  
  
  METHODS
  Post mortem and bacteriological examinations were made of five patients dying within 48 hours from rapidly fatal necrotising fasciitis.
  
  
  RESULTS
  All five cases died rapidly from a toxic Streptococcus toxin syndrome as a result of developing necrotising fasciitis following trivial injury.
  
  
  CONCLUSIONS
  Necrotising fasciitis caused by Streptococcus pyogenes infection can be rapidly fatal. This is probably the result of a toxic shock syndrome. Rapid, early diagnosis and swift and probably empirical treatment is required to avoid a fatal outcome.
authors.affiliation: Department of Clinical medicine, University of Leeds.
authors.forename: P M
authors.initials: PM
authors.lastname: Donaldson
authors.forename: B
authors.initials: B
authors.lastname: Naylor
authors.forename: J W
authors.initials: JW
authors.lastname: Lowe
authors.forename: D R
authors.initials: DR
authors.lastname: Gouldesbrough
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005208:Fasciitis / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D009336:Necrosis; D012772:Shock, Septic / Q000209:etiology; D013290:Streptococcal Infections; D013297:Streptococcus pyogenes