[Clinical and experimental study on effects of ji shen mixture for infantile acute glomerulonephritis].
33 cases of acute glomerulonephritis treated with Ji Shen Mixture (JSM) were studied with 31 cases treated with Western medical therapy (WM) for comparison and 34 healthy subjects as controls. The levels of lipo-peroxide (LPO), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), theromboxane B2 (TXB2), 6-keto-PGF1 alpha and TXB2/6-keto-PGF1 alpha ratio were examined before and after treatment. Compared with healthy controls, the levels of LPO, TXB2, TXB2/6-keto-PGF1 alpha of patients increased and that of GSH-Px, 6-keto-PGF1 alpha decreased significantly, whereas SOD activity had no significant difference. After treatment, the level of LPO reduced and GSH-Px activities raised significantly, but the effect of JSM group was better than that of WM group. It indicated that JSM was more effective in clearing the free radicals. The TXB2, TXB2/6-keto-PGF1 alpha dropped and 6-keto-PGF1 alpha elevated significantly after treatment, the effects of JSM were markedly better than those of WM. Furthermore, JSM was more potent in raising the clearing rate of hematuria and proteinuria.
Wei
J
J
First Affiliated Hospital, Xi'an Medical University.
Yan
X C
XC
Wang
J A
JA
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D013482:Superoxide Dismutase / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase