Colocalization of Fos- and glucocorticoid receptor-immunoreactivities is present only in a very restricted population of dorsal horn neurons of the rat spinal cord after nociceptive stimulation.
Immunocytochemical techniques were used to study the colocalization of proto-oncogene c-fos protein (Fos)-like immunoreactivity and of glucocorticoid receptor immunoreactivity in the spinal cord dorsal horn of adult male rats after nociceptive stimulation. About 5-10% of the stimulus evoked Fos-immunoreactive profiles colocalized glucocorticoid receptor immunoreactivity. The results suggest the possibility of a corticosteroid action in a small neuronal population of the dorsal horn implicated in processing nociceptive inputs.
Cintra
A
A
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Molander
C
C
Fuxe
K
K
D000818:Animals; D004558:Electric Stimulation; D005455:Fluorescent Antibody Technique; D015870:Gene Expression; D016762:Genes, fos; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D010146:Pain / Q000378:metabolism / Q000503:physiopathology; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000096:biosynthesis*; D012584:Sciatic Nerve / Q000502:physiology; D013116:Spinal Cord / Q000378:metabolism* / Q000502:physiology / Q000503:physiopathology
D016760:Proto-Oncogene Proteins c-fos; D011965:Receptors, Glucocorticoid