title: Sensitivity to sensitins and tuberculin in Swedish children. Part 5: A study of school children in an inland rural area.
abstract: METHODS
  Since 1986 we have tested approximately 7000 non-BCG-vaccinated Swedish children with tuberculin and with Mycobacterium avium or M. scrofulaceum sensitin. In Göteborg, an urban coastal area, 25% of 8-9-year-old school children reacted to M. avium sensitin and 32% of M. scrofulaceum sensitin using a 6 mm cut-off.
  
  
  OBJECTIVE
  To evaluate if geographical factors have an influence on the prevalence of children reacting to tuberculin and sensitins.
  
  
  METHODS
  2000 schoolchildren of the same age as those in Göteborg but living in an inland rural area were Mantoux-tested in a similar way (simultaneously on separate arms with PPD RT23 and either of the two sensitins).
  
  
  RESULTS
  15% reacted to PPD RT23, 9.7% to M. avium and 13.9% to M. scrofulaceum sensitin. None of the children with a PPD RT23 reaction > = 6 mm showed signs of tuberculosis or had any known exposure. A reaction to PPD RT23 was usually combined with a still larger sensitin reaction.
  
  
  CONCLUSIONS
  There was a considerable geographic difference in sensitin reactivity, low in an inland rural area compared to a coastal urban area. Children reacting to PPD RT23 had probably not been infected by M. tuberculosis but more likely by atypical mycobacteria. The reactions should be interpreted as cross-reactions.
authors.affiliation: Department of Pulmonary Medicine, University of Göteborg, Sweden.
authors.forename: L O
authors.initials: LO
authors.lastname: Larsson
authors.forename: M W
authors.initials: MW
authors.lastname: Bentzon
authors.forename: A
authors.initials: A
authors.lastname: Lind
authors.forename: M
authors.initials: M
authors.lastname: Magnusson
authors.forename: G
authors.initials: G
authors.lastname: Sandegård
authors.forename: B E
authors.initials: BE
authors.lastname: Skoogh
authors.forename: G
authors.initials: G
authors.lastname: Boëthius
mesh_terms: D000941:Antigens / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D002648:Child; D006801:Humans; D009162:Mycobacterium avium / Q000276:immunology*; D015359:Mycobacterium scrofulaceum / Q000276:immunology*; D012424:Rural Population; D012882:Skin Tests; D013548:Sweden; D014373:Tuberculin / Q000276:immunology*; D014505:Urban Population
chemical_list: D000941:Antigens; D000942:Antigens, Bacterial; D014373:Tuberculin; C012031:sensitin