title: [In vitro antibacterial activity of isoxazolyl++ naphthoquinones. I].
abstract: The in vitro antibacterial activity of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl) 1,4 naphthoquinone-4-imine (I) and three of this derivatives against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis y Morganella morganii was investigated. From the four naphthoquinone-imine studied, compound I exhibited activity against S. aureus. This effect was observed even in oxygen atmosphere with 5% CO2 and in the presence of human albumin. The development of drug-resistant strains by serial passage in media with concentrations lower than the C.I.M. was determined in 31 strains of S. aureus from clinical material and one from collection. No significant differences in C.I.M. were observed.
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
authors.forename: P M
authors.initials: PM
authors.lastname: Bogdanov
authors.forename: I
authors.initials: I
authors.lastname: Albesa
authors.forename: N R
authors.initials: NR
authors.lastname: Sperandeo
authors.forename: M
authors.initials: M
authors.lastname: Martínez de Bertorello
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones
vernacular_title: Actividad antibacteriana in vitro de isoxazolilnaftoquinonas. I.