title: Experience with the management of ovarian germ cell tumors in Chinese patients.
abstract: Treatment results of 37 consecutive patients with primary ovarian germ cell tumors (OGCTs) were analyzed. Thirty-three were referred after initial laparotomy and four were first seen at relapse. Four patients with stage I dysgerminoma and grade 1 immature teratoma were observed after operation without recurrence. There was also no relapse in eight patients with dysgerminoma given postoperative irradiation (whole abdomen, median 30 Gy). Twenty-five patients (3 dysgerminomas, 11 immature teratomas, 9 endodermal sinus tumors, and 2 mixed germ cell tumors) received short-term cis-platinum-based chemotherapy. Six out of eight measurable tumors treated by chemotherapy had complete remission. Complete follow-up information was obtained in 35 out of 37 patients. The 4-year actuarial survival rates of the whole group and those referred immediately after initial surgery were 94.1 and 100%, respectively. cis-Platinum was substituted by carboplatin in eight cases but this did not affect treatment result. Nonetheless, deaths occurred in two of four patients referred at relapse with extensive disease and initially treated with suboptimal regimens. Chemotherapy-induced side effects were common but mostly tolerable and were related to cis-platinum and bleomycin. The results of this series show that cis-platinum-based chemotherapy is so effective that nearly 100% cure can be achieved in OGCTs and suggest that it is important to institute optimal chemotherapy from the start. On the other hand, common side effects of treatment and possible late toxicities make it desirable for future studies to see whether chemotherapy intensity could be reduced in patients with good prognosis.
authors.affiliation: Department of Radiotherapy & Oncology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: M M
authors.initials: MM
authors.lastname: Cheung
authors.forename: W H
authors.initials: WH
authors.lastname: Lau
authors.forename: M
authors.initials: M
authors.lastname: Chan
authors.forename: S K
authors.initials: SK
authors.lastname: Teng
authors.forename: J K
authors.initials: JK
authors.lastname: Chan
authors.forename: R K
authors.initials: RK
authors.lastname: Ngan
authors.forename: V C
authors.initials: VC
authors.lastname: Sin
authors.forename: S Y
authors.initials: SY
authors.lastname: Tung
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002648:Child; D002681:China / Q000208:ethnology; D003131:Combined Modality Therapy; D005260:Female; D018237:Germinoma / Q000628:therapy*; D006801:Humans; D010051:Ovarian Neoplasms / Q000628:therapy*; D012189:Retrospective Studies