Effects of melatonin and the melatonin receptor agonist S-20098 on the vigilance states, EEG spectra, and cortical temperature in the rat.
The effects of melatonin (3 mg/kg i.p.) and the melatonin receptor agonist S-20098 (3 mg/kg i.p.) on the vigilance states, electroencephalogram power spectra (0.25-25.0 Hz), and cortical temperature were determined in eight rats in the first 6-hr interval of the 12-hr light period. Compared to the vehicle injection both compounds reduced the power density in non-rapid eye movement sleep in the low frequency range (1-8 Hz) but did not affect the vigilance states and brain temperature. The present findings do not indicate that the stimulation of the melatonin receptor exerts a hypnotic effect at doses that had been shown to affect the circadian rest-activity rhythm.
Tobler
I
I
Institute of Pharmacology, University of Zürich, Switzerland.
Jaggi
K
K
Borbély
A A
AA
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000187:drug effects*; D044094:Receptors, Melatonin; D009281:Naphthalenes
D000081:Acetamides; D008550:Melatonin; D011956:Receptors, Cell Surface; D044094:Receptors, Melatonin; C084711:agomelatine; D009281:Naphthalenes