Frameshifting and antigenic variation in respiratory syncytial virus.
Recent studies have suggested that frameshift mutations in the attachment protein gene of respiratory syncytial (RS) virus may contribute to its variability. Many pathogens use several mechanisms for antigenic variation to elude their hosts' immune responses, and the frameshift mechanism is not unique to RS virus. Indeed, it may turn out to be a widespread genetic phenomenon among pathogens.
Cane
P A
PA
Dept of Biological Sciences, University of Warwick, Coventry, UK.
D000956:Antigens, Viral / Q000235:genetics*; D001483:Base Sequence; D016368:Frameshift Mutation; D014644:Genetic Variation; D015707:HN Protein; D008969:Molecular Sequence Data; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000235:genetics*
D000956:Antigens, Viral; D015707:HN Protein; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C116204:attachment protein G