title: Effect of oxytetracycline on metacarpophalangeal and distal interphalangeal joint angles in newborn foals.
abstract: Thirty-five newborn foals were assigned to 1 of 3 groups and treated with 0.9% NaCl solution (saline; group 1; n = 12), oxytetracycline (44 mg/kg of body weight; group 2; n = 12), or 2-pyrrolidone (oxytetracycline vehicle; group 3; n = 11) in saline solution during the first 36 hours after birth. Serum biochemical analyses were performed on samples obtained from group-1 and group-2 foals before treatment and 24 and 96 hours after treatment. Lateral to medial radiographic views of the forelimbs were obtained before treatment and 24 and 96 hours after treatment in all foals. Metacarpophalangeal and distal interphalangeal joint angles were measured from the radiographic images. Significant changes in blood chemistry values, other than those typically observed in newborn foals, were not detected. A significant decrease in mean metacarpophalangeal joint angle was observed in foals 24 hours after treatment with oxytetracycline, compared with that in foals of groups 1 and 3. The mean metacarpophalangeal joint angle returned to pretreatment values by 96 hours. Oxytetracycline appears to be an effective method for obtaining a short-term moderate decrease in metacarpophalangeal joint angle in newborn foals.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Gainesville 32610-0136.
authors.forename: J B
authors.initials: JB
authors.lastname: Madison
authors.forename: J L
authors.initials: JL
authors.lastname: Garber
authors.forename: B
authors.initials: B
authors.lastname: Rice
authors.forename: A J
authors.initials: AJ
authors.lastname: Stumf
authors.forename: A E
authors.initials: AE
authors.lastname: Zimmer
authors.forename: E A
authors.initials: EA
authors.lastname: Ott
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001806:Blood Urea Nitrogen; D000013:Congenital Abnormalities / Q000188:drug therapy / Q000662:veterinary; D003404:Creatinine / Q000097:blood; D005552:Forelimb; D006736:Horses / Q000002:abnormalities / Q000033:anatomy & histology*; D007596:Joints / Q000002:abnormalities / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D010118:Oxytetracycline / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011760:Pyrrolidinones / Q000494:pharmacology
chemical_list: D011760:Pyrrolidinones; D003404:Creatinine; C028537:2-pyrrolidone; D010118:Oxytetracycline