[Antibiotic activity of cortalcerone and its 7-diphenylhydrazone derivative].
The present paper investigates the antibiotic properties of the novel antifungal antibiotic agent cortalceron and its semisynthetic derivative cortalceron 7-diphenylhydrazone. The MIC values were assayed by the agar diffusion method. Cortalceron was found to weakly inhibit the growth of E. coli and B. subtilis. The growth of yeast was not influenced. On i.v. administration to mice [correction of rats], the agent produced breathing disorders and convulsions which later disappeared. The diphenylhydrazine derivative of cortalceron inhibited the growth of most yeasts tested as well.
Gabriel
J
J
Mikrobiologický ústav AVCR, Praha.
Volfová
I
I
Palková
Z
Z
Pospísek
M
M
Urban
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D000935:Antifungal Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D011753:Pyrones / Q000494:pharmacology / Q000633:toxicity
C086504:2-hydroxy-2H-pyran-3(6H)-one-2-carboxaldehyde diphenylhydrazone; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006835:Hydrazones; D011753:Pyrones; C077712:cortalcerone
Antibiotická aktivita cortalceronu a jeho 7-difenylhydrazonu.