[The immunogenic properties and prophylactic efficacy of a live polyvalent influenza vaccine in children 5 to 14 years old].
Production lots of a live influenza vaccine made of strains A/47/T (N1H1), A/47/6/2 (H3N2), and B/60/32 were used for vaccination of 3663 children aged from 5 to 14 years inoculated twice with monovaccines, a trivaccine made of the above strains, or placebo. Both mono- and polyvaccine were practically areactogenic. An average per cent of subjects with a significant rise in antibody titres to the respective three antigens was 60%. The efficacy of the vaccination was 31.0-42.8% for monopreparations and 36.3% for the trivaccine. The studies showed the possibility and expedience of using for children the live influenza vaccine in the form of a polyvalent preparation including current influenza type A and B viruses.
Grigor'eva
E P
EP
Rekstin
A R
AR
Rudenko
L G
LG
Ramirez
A
A
Barro
M
M
Lisovskaia
K V
KV
Klimov
A I
AI
Aleksandrova
G I
GI
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003462:Cuba; D004341:Drug Evaluation; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D009981:Influenza B virus / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000235:genetics / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control*; D014505:Urban Population; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000235:genetics / Q000276:immunology*
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014614:Vaccines, Synthetic
Izuchenie immunogennykh svoĭstv i profilakticheskoĭ éffektivnosti zhivoĭ grippoznoĭ polivalentnoĭ vaktsiny u deteĭ 5--14 let.