title: Alpha 2-adrenergic activity is normal in patients with thyroid disease.
abstract: OBJECTIVE
  Several studies indicate an inverse relationship between the sympathetic nervous system activity and thyroid function. Altered adrenoceptor sensitivity, particularly alpha 1 and beta, have been described in hypothyroid and hyperthyroid patients. No information in patients with thyroid disease is available on the main mechanism regulating sympathetic nervous system outflow, i.e. the alpha 2-adrenoceptor pathway. In our study we evaluated alpha 2-adrenergic activity in patients with thyroid disease by the assessment of cardiovascular and catecholamine response to clonidine, a central alpha 2 adrenergic agonist.
  
  
  METHODS
  Ten patients with hypothyroidism, six patients with hyperthyroidism before and during adequate therapy, and ten healthy subjects.
  
  
  METHODS
  After three blood samples for the basal determination of noradrenaline and adrenaline, the subjects swallowed 4 micrograms/kg body weight of clonidine. Blood pressure and pulse rate were measured 30, 60, 90, 120, 130 and 140 minutes after clonidine administration; blood samples for determination of catecholamines were drawn at 120, 130 and 140 minutes.
  
  
  RESULTS
  At presentation the decrease in plasma noradrenaline after clonidine in the patients was similar to that of the control group (hypothyroids: 1.07 +/- 0.23 nmol/l mean +/- SEM; hyperthyroids: 0.54 +/- 0.06 nmol/l; controls; 0.36 +/- 0.10 nmol/l; F = 1.2, P = NS). No differences were detected in the fall in adrenaline and mean arterial pressure (MAP) after clonidine. The adequate therapy induced in hypothyroid patients a decrease in the basal levels of noradrenaline (1.88 +/- 0.28 vs 0.67 +/- 0.10 nmol/l; P < 0.05) and a lesser fall in mean arterial pressure after clonidine (delta MAP 20.4 +/- 2.0 vs 9.7 +/- 2.8 mmHg; P < 0.05). No variations were detected in hyperthyroid patients after therapy either in basal hormones levels or in the magnitude of decrement in MAP and noradrenaline induced by clonidine.
  
  
  CONCLUSIONS
  We conclude that in spite of the previously reported abnormalities in alpha 1 and beta-adrenergic receptor activity, the inhibitory alpha 2-receptor pathway is normal in patients with altered thyroid function.
authors.affiliation: Department of Endocrinology and Metabolism, University of Modena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Del Rio
authors.forename: G
authors.initials: G
authors.lastname: Zizzo
authors.forename: P
authors.initials: P
authors.lastname: Marrama
authors.forename: M G
authors.initials: MG
authors.lastname: Venneri
authors.forename: L
authors.initials: L
authors.lastname: Della Casa
authors.forename: A
authors.initials: A
authors.lastname: Velardo
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood*; D003000:Clonidine / Q000008:administration & dosage; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D007037:Hypothyroidism / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D011674:Pulse / Q000187:drug effects; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000378:metabolism*; D013268:Stimulation, Chemical; D013959:Thyroid Diseases / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D018341:Receptors, Adrenergic, alpha-2; D003000:Clonidine; D009638:Norepinephrine; D004837:Epinephrine