Plasma insulin-like growth factor-I, CA-125, estrogen, and progesterone in women with leiomyomas.
OBJECTIVE
To determine plasma levels of insulin-like growth factor-I (IGF-I), CA-125, estrone (E1), E2, and P in women with uterine leiomyomas compared with normal women.


METHODS
Women with leiomyomas were compared with normal women (control).


METHODS
University Department of Obstetrics and Gynecology.


METHODS
Fifty-one premenopausal women with uterine myomas > 14 weeks gestation and 30 normal fertile women (controls) were studied. Peripheral blood samples were obtained before myomectomy or hysterectomy and during the nonmenstruating phase in the controls.


METHODS
Plasma levels of E1, E2, P, CA-125, and IGF-I were determined by specific and sensitive RIAs and immunoradiometric assays.


RESULTS
Plasma IGF-I levels were 2,006 +/- 185 mU/mL (mean +/- SEM, n = 35) and 2,335 +/- 287 mU/mL (n = 16) in women with leiomyomas during the follicular and luteal phases, respectively, whereas the corresponding values for normal women were 1,702 +/- 120 (n = 30) and 1,774 +/- 239 mU/mL (n = 30). Similarly, plasma CA-125 levels were unchanged in women with leiomyomas (myomas: 18.8 +/- 2.4, 21.5 +/- 3.7 U/mL; normal: 15.9 +/- 1.5, 15.8 +/- 1.3 U/mL during follicular and luteal phases, respectively). Women with leiomyomas had plasma E1, E2, and P levels during the follicular phase (91.9 +/- 11.5 pg/mL; conversion factor to SI unit, 3.699; 94.6 +/- 19.0 pg/mL; conversion factor to SI unit, 3.671; and 1.5 +/- 0.4 ng/mL; conversion factor to SI unit, 3.180, respectively) and the luteal phase (105.8 +/- 11.2 pg/mL; conversion factor to SI unit, 3.699; 128.7 +/- 24.8 pg/mL; conversion factor to SI unit, 3.671; and 9.6 +/- 1.6 ng/mL; conversion factor to SI unit, 3.180) similar to normal women.


CONCLUSIONS
Plasma levels of IGF-I, CA-125, E1, E2, and P are normal in women with leiomyomas.
Dawood
M Y
MY
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Medical School at Houston 77030.
Khan-Dawood
F S
FS
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000097:blood*; D004970:Estrone / Q000097:blood; D005260:Female; D005498:Follicular Phase / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007889:Leiomyoma / Q000097:blood*; D008183:Luteal Phase / Q000097:blood; D008875:Middle Aged; D011374:Progesterone / Q000097:blood*; D014594:Uterine Neoplasms / Q000097:blood*
D015295:Antigens, Tumor-Associated, Carbohydrate; D004967:Estrogens; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I