Endothelin-1 in children with chronic renal failure.
Endothelin-1 (ET-1) was measured after extraction from plasma of normal adults (5.9 +/- 1.9 pg/ml, n = 22), normal children (7.1 +/- 1.86 pg/ml, n = 29), non-haemodialysed children with chronic renal failure (CRF) (11.1 +/- 1.8 pg/ml), n = 10), renal graft recipients (9.5 +/- 3.4 pg/ml, n = 37), haemodialysed children 24 h after a haemodialysis session (20.02 +/- 10.9 pg/ml, n = 26) and haemodialysed children before and after a haemodialysis session (15.31 +/- 10.6 and 13.8 +/- 8.5 respectively, n = 14). A sensitive and specific radioimmunoassay was used. ET-1 was significantly higher in non-haemodialysed CRF children and in renal graft recipients than in normal children (P < 0.001 and P < 0.01, respectively) and significantly higher in haemodialysed children when compared with normal children, non-haemodialysed CRF children and renal graft recipients (P < 0.001). ET-1 concentrations were similar in normal children and normal adults. ET-1 was inversely correlated with glomerular filtration rate in non-haemodialysed CRF children (r = -0.39, P < 0.01) and positively correlated with extracellular volume in haemodialysed children (r = 0.435, P < 0.03). After haemodialysis, ET-1 increased in 6 and decreased in 8 of the 14 children studied before and after a haemodialysis session.
Blazy
I
I
Department of Physiology, C.H.U. Necker-Enfants Malades, Paris, France.
Déchaux
M
M
Charbit
M
M
Brocart
D
D
Souberbielle
J C
JC
Gagnadoux
M F
MF
Guillot
F
F
Sachs
C
C
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016232:Endothelins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D006435:Renal Dialysis
D016232:Endothelins