[Study of anti-HIV activity of azidothymidine and fluorothymidine 5'-phosphonates].
It was established that 5'-phosphonates of 3'-azido-2',3'-dideoxythymidine (AZT) inhibit HIV reproduction in the MT-4 cell line as well as AZT. However, the viability of HIV-infected MT-4 cells after treatment with phosphonates was considerable higher that after AZT treatment. Inhibitory activities of 5'-phosphonates of 3'-fluoro-2',3'-dideoxythymidine (FLT) on HIV-infected MT-4 cells were rather low. The mechanism of action of these derivatives and prospects for their application for suppressing HIV infection are discussed.
Mamaeva
O A
OA
Pliasunova
O A
OA
Pokrovskiĭ
A G
AG
Diatkina
N B
NB
Arzumanova
A A
AA
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival; D002478:Cells, Cultured; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D009943:Organophosphorus Compounds; C068636:2'-fluorothymidine; D015215:Zidovudine; D013936:Thymidine
Izuchenie anti-HIV-aktivnosti 5'-fosfonatov azidotimidina i ftortimidina.