Fatal methemoglobinemia due to inhalation of isobutyl nitrite.
Isobutyl nitrite is a popular recreational drug among both homosexuals and heterosexuals as it is alleged to enhance sexual pleasure and prolong orgasm. In contrast to the ingestion of this volatile nitrite, inhalation is associated only rarely with serious sequelae, though symptomatic methemoglobinemia may occur. The case reported is the first documented fatality from inhalation of isobutyl nitrite. The widespread use of isobutyl nitrite is a cause for concern and physicians should be aware of the potentially fatal consequence of abuse, particularly in those with ischemic heart disease, and its management.
Bradberry
S M
SM
National Poisons Information Service (Birmingham Center), West Midlands Poisons Unit, Dudley Road Hospital, Birmingham, United Kingdom.
Whittington
R M
RM
Parry
D A
DA
Vale
J A
JA
D000280:Administration, Inhalation; D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D009573:Nitrites / Q000008:administration & dosage / Q000506:poisoning*; D019966:Substance-Related Disorders
D009573:Nitrites; C018086:isobutyl nitrite