Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver.
1. The kinetics and metabolism of diosmin and diosmetin were investigated in the isolated perfused rat liver in order to assess the role of the liver. 2. Diosmetin and especially diosmin disappeared quickly from the perfusion medium. 3. Both flavonoids were rapidly metabolized and diosmetin was partly excreted in bile as the glucuronide and sulphate and diosmin was partly excreted in bile as such and as the glucuronide conjugate. 4. Diosmin and diosmetin did not appear to affect various parameters of liver function.
Perego
R
R
CNR (National Research Council), Center of Cytopharmacology, Department of Pharmacology, Milan, Italy.
Beccaglia
P
P
Angelini
M
M
Villa
P
P
Cova
D
D
D000818:Animals; D001646:Bile / Q000378:metabolism; D004145:Diosmin / Q000378:metabolism / Q000493:pharmacokinetics*; D005419:Flavonoids / Q000378:metabolism / Q000493:pharmacokinetics*; D005965:Glucuronates / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D013431:Sulfates / Q000378:metabolism
D005419:Flavonoids; D005965:Glucuronates; D013431:Sulfates; D004145:Diosmin; C039602:diosmetin