title: Crohn's disease and cystic fibrosis.
abstract: Advances in investigative techniques have led to increasing reports of Crohn's disease in CF patients. A retrospective review of the literature on IBD in CF showed findings characterized by ileocolitis with fistula formation; 83% required surgery. A prospective survey of 11,321 CF patients attending 49 CF centers revealed 28 with IBD (25 Crohn's, three ulcerative colitis), ages 4-20 years, mean 15.6 years. The prevalence rate of IBD (247/10(5)) was 7x controls and was accounted for by Crohn's disease (221/10(5)) which was 17x controls. The mechanisms that predispose CF patients to Crohn's disease are discussed.
authors.affiliation: Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614.
authors.forename: J D
authors.initials: JD
authors.lastname: Lloyd-Still
mesh_terms: D000293:Adolescent; D000328:Adult; D015984:Causality; D003424:Crohn Disease / Q000453:epidemiology*; D003550:Cystic Fibrosis / Q000453:epidemiology*; D003625:Data Collection; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D011446:Prospective Studies