[Urinary minor proteins, beta 2-microglobulin (beta 2-MG) assay with pregnancy induced hypertension (PIH)].
Urinary minor protein (Alb, IgA, IgG, IgM) contents were determined by ELISA method and beta 2-MG were determined by Radioimmuno Assay (RIA) method in 50 patients with PIH and in 50 normal pregnant women. It was showed that A1b in all patients with PIH was significantly increased than that of the normal control (P < 0.001). There was a significantly difference of urine IgA, IgG, IgM in each type of PIH (P < 0.05). Serum beta 2-MG level was significantly increased in patients with severe PIH, (P < 0.001) and it was positively correlated with serum uric acid. This study indicated that the combination of ELISA and RIA may be helpful to understand both the location and severity of lesion in the kidney with PIH.
Zhang
S J
SJ
RuiJin Hospital, Shanghai Second Medical University.
D000328:Adult; D000419:Albuminuria / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine; D007074:Immunoglobulin G / Q000652:urine; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011863:Radioimmunoassay; D001613:beta 2-Microglobulin / Q000652:urine*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D001613:beta 2-Microglobulin