Ankyrin inhibits binding of erythrocyte spectrin to phospholipid vesicles.
The studies on binding of erythrocyte spectrin to frozen and thawed phospholipid liposomes and its inhibition by ankyrin were performed. It was found that ankyrin inhibited up to 60% binding of spectrin by phosphatidylethanolamine/phosphatidylcholine vesicles. It was able to dissociate up to 40% of spectrin from this complex. Ankyrin inhibition of binding of phosphatidylserine/phosphatidylcholine vesicles by spectrin, although much lower, was also observed.
Białkowska
K
K
University of Wrocław, Institute of Biochemistry, Poland.
Zembroń
A
A
Sikorski
A F
AF
D000818:Animals; D017487:Ankyrins / Q000494:pharmacology*; D001665:Binding Sites; D002417:Cattle; D004910:Erythrocyte Membrane / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D013049:Spectrin / Q000378:metabolism*
D017487:Ankyrins; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D013049:Spectrin