Deformation kinetics of potassium bromide crystals predict tablet stress relaxation.
A model relating the interparticulate contact stress within a tablet matrix with the compaction stress was developed previously to permit the nonlinear deformation kinetic analysis of the viscoelastic behavior of pharmaceutical tablets with the known properties of the tablet constituents. The present research was undertaken to determine whether the inverse operation (i.e., using tablet stress relaxation to determine single crystal properties) was possible. The stress relaxation of potassium bromide (KBr) compacts was evaluated as a function of temperature and relative density, and an attempt was made to calculate the deformation kinetic parameters. The stress relaxation of KBr did not fit the model under ambient conditions for two reasons: (1) KBr has two slip systems with approximately the same shear stress at room temperature; and (2) KBr strain-hardens. When these complications were taken into consideration, the stress relaxation behavior could be explained. Therefore, whereas single crystal tests are capable of yielding parameters that can be used to predict compact behavior, the inverse process of quantifying fundamental material parameters from compact behavior is problematic due to the difficulty of determining, a priori, all the processes that operate simultaneously.
Duncan-Hewitt
W C
WC
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
Papadimitropoulos
E A
EA
D001965:Bromides / Q000008:administration & dosage*; D003460:Crystallization; D007700:Kinetics; D017680:Potassium Compounds / Q000008:administration & dosage*; D013607:Tablets; D013696:Temperature
D001965:Bromides; D017680:Potassium Compounds; D013607:Tablets; C039004:potassium bromide