title: Atrial natriuretic factor potentiates the human forearm vasoconstrictor response to sympathetic stimulation.
abstract: 1. Atrial natriuretic factor has been suggested to affect human sympathetic nervous system activity. The interaction between atrial natriuretic factor and the sympathetic nervous system has not been fully elucidated yet, but may occur at different sites. We studied this modulator effect at the level of the forearm vascular bed: the forearm vasoconstrictor response was examined after alpha-adrenergic sympathetic stimulation in healthy subjects during the locoregional administration of atrial natriuretic factor, sodium nitroprusside and placebo. As a sympathetic stimulation test, the technique of the lower body negative pressure (-20 mmHg) was used. 2. Lower body negative pressure increased the forearm vascular resistance by +37 +/- 8% during concomitant intra-arterial infusion of placebo (n = 10). During a predilator state achieved by infusion of atrial natriuretic factor (10 ng min-1 100 ml-1 forearm volume) into the brachial artery, lower body negative pressure subsequently induced a forearm vasoconstrictor response of +153 +/- 22% (P < 0.05 versus placebo), whereas this was +64 +/- 14% when predilatation was achieved by infusion of an equipotent vasodilator dose of sodium nitroprusside (P > 0.1 versus placebo; P < 0.05 versus atrial natriuretic factor). The potentiation of the forearm vasoconstrictor response to lower body negative pressure by atrial natriuretic factor only occurred in the experimental and not in the contralateral arm. According to calculations on simultaneously sampled arterial and venous plasma catecholamine concentrations, the augmented forearm vasoconstrictor response seemed not to be caused by an increased release of noradrenaline.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University Hospital Nijmegen, The Netherlands.
authors.forename: T L
authors.initials: TL
authors.lastname: Jansen
authors.forename: P
authors.initials: P
authors.lastname: Smits
authors.forename: J W
authors.initials: JW
authors.lastname: Lenders
authors.forename: M C
authors.initials: MC
authors.lastname: Jacobs
authors.forename: J
authors.initials: J
authors.lastname: Willemsen
authors.forename: T
authors.initials: T
authors.lastname: Thien
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D008150:Lower Body Negative Pressure; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology
chemical_list: C472955:NPPA protein, human; D009599:Nitroprusside; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine