title: Fc receptor-mediated signal transduction.
abstract: Receptors for the Fc domain of IgG (Fc gamma Rs) on leukocytes mediate a pleiotropic response following cross-linking by immune complexes. Signaling events following cross-linking of B and T cell antigen receptors, Fc epsilon RI, and Fc gamma Rs share common elements. In each, signaling is initiated by receptor cross-linking by antigen or immune complexes and results in the activation of src family kinases and ZAP-70-related tyrosine kinases, which associate with members of the receptor complex. Subsequent events include phosphorylation on tyrosine of multiple cellular substrates including phospholipase C gamma 1 and PI3-kinase. The [Ca2+]i flux is an event secondary to phospholipase C gamma 1 activation. Protein tyrosine kinase inhibitors block both early events such as [Ca2+]i flux and the later effects of cytokine release and cellular proliferation.
authors.affiliation: Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029-6574.
authors.forename: C T
authors.initials: CT
authors.lastname: Lin
authors.forename: Z
authors.initials: Z
authors.lastname: Shen
authors.forename: P
authors.initials: P
authors.lastname: Boros
authors.forename: J C
authors.initials: JC
authors.lastname: Unkeless
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D002460:Cell Line; D017261:Glycosylphosphatidylinositols / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011961:Receptors, Fc / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D017261:Glycosylphosphatidylinositols; D007074:Immunoglobulin G; D011961:Receptors, Fc; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases