title: Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues.
abstract: We determined activities of adenosine deaminase (ADA), 5' nucleotidase (5NT), xanthine oxidase (XO), superoxide dismutase (Cu-Zn SOD), and catalase (CAT) enzymes in 15 human laryngeal tissues with well-differentiated squamous cell carcinomas, in 15 corresponding tumor-free adjacent tissues and in 7 normal laryngeal tissues. We found lower ADA and 5NT and higher XO, Cu-Zn SOD, and CAT activities in cancerous tissues than those in corresponding noncancerous ones. In the correlation analysis, we established one positive intercorrelation, which was between ADA activities of tumor tissues and noncancerous adjacent tissues. We also found some significant intracorrelations between enzyme activities of the tissues, all of which were positive in cancerous ones.
authors.affiliation: Department of Biochemistry, Ankara University, Faculty of Medicine, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Durak
authors.forename: A C
authors.initials: AC
authors.lastname: Işik
authors.forename: O
authors.initials: O
authors.lastname: Canbolat
authors.forename: O
authors.initials: O
authors.lastname: Akyol
authors.forename: M
authors.initials: M
authors.lastname: Kavutçu
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D007830:Larynx / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004273:DNA, Neoplasm; D005609:Free Radicals; D004247:DNA; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase