Transformation of myelomonocytic cells by the avian myeloblastosis virus is determined by the v-myb oncogene, not by the unique long terminal repeats of the virus.
The avian myeloblastosis virus (AMV) induces acute monoblastic leukemia in chickens and transforms only myelomonocytic cells in vitro. The long terminal repeat (LTR) regulatory region of AMV is unique among the known classes of avian retrovirus LTRs. We demonstrate that the substitution of the AMV LTRs by Rous sarcoma virus LTRs did not alter the cell type specificity or the transforming ability of the virus.
Engelke
U
U
Department of Pathology, Stanford University School of Medicine, California 94305-5324.
Lipsick
J S
JS
D000818:Animals; D009189:Avian Myeloblastosis Virus / Q000235:genetics*; D001483:Base Sequence; D002472:Cell Transformation, Viral / Q000235:genetics*; D002642:Chick Embryo; D016679:Genome, Viral; D006378:Helper Viruses / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000382:microbiology*; D008969:Molecular Sequence Data; D009857:Oncogenes; D011533:Proviruses / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid