title: 4-Ethoxyamphetamine: effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats.
abstract: Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel "designer" amphetamine, with (+)-amphetamine and an earlier "designer" amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamphetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton Canada.
authors.forename: K M
authors.initials: KM
authors.lastname: Hegadoren
authors.forename: A J
authors.initials: AJ
authors.lastname: Greenshaw
authors.forename: G B
authors.initials: GB
authors.lastname: Baker
authors.forename: M T
authors.initials: MT
authors.lastname: Martin-Iverson
authors.forename: B
authors.initials: B
authors.lastname: Lodge
authors.forename: S
authors.initials: S
authors.lastname: Soin
mesh_terms: D000662:Amphetamines / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012653:Self Stimulation / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D013238:Stereotaxic Techniques
chemical_list: D000662:Amphetamines; D012701:Serotonin; D004298:Dopamine