Immunohistochemical detection of proliferating tumor cells in cervical cancer using monoclonal antibody Ki-67.
Monoclonal antibody Ki-67 identifies cells in G1, S, G2, and M phases of the cell cycle. In this cytokinetic study, Ki-67 was used to characterize tumor cells in human cervical cancer specimen. This immunohistochemical study showed that Ki-67 staining gave a brown nuclear reactivity dispersed heterogeneously in a tumor cell population and correlated well with the mitotic activities of tumor cells. The finding suggested that Ki-67 staining provides an easily countable index for the study of proliferating cell populations in cervical cancer.
Wong
F W
FW
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Shatin, New Territories.
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins / Q000276:immunology; D009687:Nuclear Proteins / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins