title: Prospective evaluation of cell kinetics in head and neck squamous carcinoma: the relationship to tumour factors and survival.
abstract: Tumour growth rates were measured in 105 patients using in vivo incorporation of bromodeoxyuridine (BrdU) and investigated for any relationship to tumour factors or survival. The median labelling index (LI) was 8.7%, the duration of S-phase (Ts) was 14 h and the potential doubling time (Tpot) was 5.9 days. The labelling index in aneuploid tumours was significantly higher than that in diploid tumours. However the total labelling index (TLI) did not differ significantly between aneuploid and diploid tumours, and so it would seem likely that the difference in LI is due to the dilutional effect of benign tissue upon the calculation of LI in diploid tumours. The total labelling index, duration of S-phase and potential doubling time were not related to the tumour factors examined (site, T stage, N stage, stage grouping). Interim survival analysis was carried out and there was no difference in survival between those patients with high values for TLI, Ts, and Tpot and those with low values.
authors.affiliation: Department of Surgery, Glasgow Royal Infirmary, UK.
authors.forename: L D
authors.initials: LD
authors.lastname: Cooke
authors.forename: T G
authors.initials: TG
authors.lastname: Cooke
authors.forename: G
authors.initials: G
authors.lastname: Forster
authors.forename: A S
authors.initials: AS
authors.lastname: Jones
authors.forename: P M
authors.initials: PM
authors.lastname: Stell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000782:Aneuploidy; D001973:Bromodeoxyuridine / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002452:Cell Count; D002455:Cell Division; D016009:Chi-Square Distribution; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D016196:S Phase; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D004273:DNA, Neoplasm; D001973:Bromodeoxyuridine