title: Introduction to the study of adult T-cell leukemia and HTLV-I sero-positivity in Romania.
abstract: The study presents 6 cases of leukemia/lymphoma (with mature T-cells) corresponding to the diagnostic criteria of adult T-cell leukemia (ATL): adult age onset of leukemia/lymphoma, organomegaly but normal mediastinum, leukemic cells with typical morphology and phenotype hypercalcemia. The evolution of disease was severe of subacute with resistance or partial response to therapy. The virologic assays were positive according to the ELISA test in four cases of which two presented, according to the Western blot assay, HTLV-I infection. The epidemic aspect of this infection is discussed as well as the possibility of contamination and the geographic spread of the places of origin of the patients. Emphasis is laid on the young age (22-26 years) of three of the patients infected, as a peculiar feature of the disease in Romania.
authors.affiliation: Clinic of Hematology, Fundeni Hospital, Bucharest, Romania.
authors.forename: I R
authors.initials: IR
authors.lastname: Moţoiu
authors.forename: M M
authors.initials: MM
authors.lastname: Pecek
authors.forename: A
authors.initials: A
authors.lastname: Dumitrescu
authors.forename: A
authors.initials: A
authors.lastname: Coliţă
authors.forename: A
authors.initials: A
authors.lastname: Necula
authors.forename: E
authors.initials: E
authors.lastname: Moldoveanu
authors.forename: D
authors.initials: D
authors.lastname: Coliţă
mesh_terms: D000328:Adult; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood*; D015490:HTLV-I Infections / Q000175:diagnosis / Q000453:epidemiology; D015482:HTLV-II Antibodies / Q000097:blood; D006801:Humans; D015458:Leukemia, T-Cell / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012383:Romania / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies