[An intranasal method of revaccination against mumps].
The effectiveness of revaccination against mumps was studied using different routes for administration of a live mumps vaccine from L-3 strain. Poor reactogenicity of the vaccine was observed after intranasal administration. The highest rise in titres of virus-neutralizing antibody was demonstrated in volunteers given the vaccine by the intranasal route. Revaccination of adults by both intranasal and subcutaneous routes induced production of antigen-specific memory cells. The results of the study attest to the usefulness of the intranasal route of vaccine administration in revaccinations against epidemic parotitis.
Krasnova
V P
VP
Iuminova
N V
NV
Liashenko
V A
VA
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D007279:Injections, Subcutaneous; D008213:Lymphocyte Activation; D009107:Mumps / Q000276:immunology / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D009109:Mumps virus / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D009108:Mumps Vaccine
Intranazal'nyĭ sposob revaktsinatsii protiv épidemicheskogo parotita.