title: The hypoxic moderation of systemic hypertension in spontaneously hypertensive rats.
abstract: The mechanism of hypoxic moderation of systemic systolic blood pressure was investigated in spontaneously hypertensive rats (SHR). Male SHR rats were divided into hypoxic (H, 5000 m for 15 d) and normoxic (N) groups. The systemic blood pressure of SHR-H (24.9 +/- 1.2 kPa) was found to be 3 kPa lower than that in SHR-N (27.0 +/- 1.3 kPa) (P < 0.05). This protective effect may have been related to the adaptive changes in vascular reactivity which manifested as an increase in the relaxation response of the aorta to ACh (P < 0.01) and a drop in its contraction in response to 5-HT (P < 0.05) following hypoxic exposure. The hypoxic moderating effect against the development of systemic hypertension may have also been related to the increased plasma levels of ANP observed.
authors.affiliation: Dept. of Physiology, Institute of Basic Medical Sciences, CAMS, Beijing.
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: X
authors.initials: X
authors.lastname: Deng
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Liang
authors.forename: Q
authors.initials: Q
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000531:Altitude; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012083:Renin / Q000097:blood
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D012083:Renin