Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).
The acyclic nucleotide analogues, HPMPC and PMEA, differ in their in vitro effect on the genetic material of eukaryotic cells. While HPMPC exerts a cytostatic effect on eukaryotic cells in vitro, PMEA has a genotoxic activity. These results correspond with the mode of embryotoxic action of these compounds: HPMPC exhibits a general embryolethal effect, whereas PMEA is apparently teratogenic and interacts with the mutant allele producing preaxial polydactyly of the hind limbs.
Bílá
V
V
Department of Biology, 1st Faculty of Medicine, Charles University, Praha.
Otová
B
B
Jelínek
R
R
Sladká
M
M
Mejsnarová
B
B
Holý
A
A
Kren
V
V
D000225:Adenine / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D002460:Cell Line; D002478:Cells, Cultured; D002642:Chick Embryo; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008938:Mitosis; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000633:toxicity*; D017689:Polydactyly / Q000139:chemically induced; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C053001:adefovir; D003596:Cytosine; D000225:Adenine; D000077404:Cidofovir