title: Histopathological and adhesion formation after incision using ultrasonic vibrating scalpel and regular scalpel in the rat.
abstract: OBJECTIVE
  To evaluate and to compare changes that occur in the uterine tissue of the rat after a standard incision with an ultrasonic vibrating scalpel and with a regular scalpel.
  
  
  METHODS
  Sprague-Dawley white rats (Charles River Canada Inc., St. Constant, Quebec, Canada) in a conventional laboratory setting.
  
  
  METHODS
  A standardized incision was performed on the uterine horn with a regular scalpel on one uterine horn and with an ultrasonic scalpel on the opposite horn.
  
  
  METHODS
  Degree of adhesions and histopathological changes of the uterine horns.
  
  
  RESULTS
  The degree of adhesion formation was similar, but the uterine horn distal to the incision was dilated in most uterine horns that were incised with ultrasonic scalpel. The degree of coagulation necrosis was significantly higher 7 and 14 days after incision with an ultrasound scalpel than after incision with a regular scalpel.
  
  
  CONCLUSIONS
  The use of an ultrasonic vibrating scalpel is associated with more tissue injury than that of a regular scalpel, but it does not produce more adhesion formation.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Tulandi
authors.forename: K L
authors.initials: KL
authors.lastname: Chan
authors.forename: J
authors.initials: J
authors.lastname: Arseneau
mesh_terms: D000818:Animals; D005260:Female; D007813:Laparotomy; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012086:Reoperation; D013525:Surgical Instruments; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology; D014464:Ultrasonic Therapy / Q000009:adverse effects*; D014591:Uterine Diseases / Q000209:etiology* / Q000473:pathology; D014599:Uterus / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery*