Synthesis of antitumour carbon-bridged imidazopyridazine carbamates.
Two carbon-bridged analogues 11 and 15 of the potent microtubule inhibitor BW1069C85 (1) have been synthesised and evaluated for antitubulin and antitumour activity in vitro. Though the compounds were somewhat less potent than BW1069C85, significant activity against tubulin polymerisation and cell proliferation was demonstrated in the assays.
Denyer
C V
CV
Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Reddy
M T
MT
Jenkins
D C
DC
Rapson
E
E
Watts
S D
SD
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006736:Horses; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014404:Tubulin / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C086346:BW 1069C85; D002219:Carbamates; D007093:Imidazoles; D011724:Pyridazines; D014404:Tubulin