title: Microencapsulation within crosslinked polyethyleneimine membranes.
abstract: A microencapsulation technique is proposed involving the formation of a polyethyleneimine (PEI) membrane crosslinked by an acid dichloride. The membranes were formed at pH 8 in a non-polar solvent, conditions which are better suited for the encapsulation of biocatalysts or fragile biochemicals than those using polyamide membranes. The mean diameter and size distribution of the PEI microcapsules were similar to that observed with nylon membranes. The resultant microcapsules were spherical, free-flowing with a strong membrane. The mass of membrane was seen to be independent of the reaction time (1-4 min), insensitive to the PEI concentration and proportional to the concentration of crosslinking agent.
authors.affiliation: Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Poncelet
authors.forename: T
authors.initials: T
authors.lastname: Alexakis
authors.forename: B
authors.initials: B
authors.lastname: Poncelet de Smet
authors.forename: R J
authors.initials: RJ
authors.lastname: Neufeld
mesh_terms: D000473:Alkanes; D001979:Bromthymol Blue; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008567:Membranes, Artificial; D009994:Osmolar Concentration; D011094:Polyethyleneimine / Q000737:chemistry*; D012997:Solvents
chemical_list: D000473:Alkanes; D003432:Cross-Linking Reagents; D008567:Membranes, Artificial; D012997:Solvents; C061659:sebacoyl chloride; D011094:Polyethyleneimine; D001979:Bromthymol Blue