Effect of ethanol on extracellular 5-hydroxytryptamine output in rat frontal cortex.
The effect of acute administration of ethanol on the release of 5-hydroxytryptamine (5-HT) in the frontal cortex of "Sardinian alcohol preferring" rats, "Sardinian non-preferring" rats and control rats was investigated using in vivo microdialysis. At the dosage of 2.5 g/kg i.p. ethanol increased the level of 5-HT in the dialysate by approximately 80 +/- 20% of basal values in the Sardinian alcohol preferring rats whereas no effect was observed in Sardinian non-preferring and control rats.
Portas
C M
CM
Department of Neuroscience B.B. Brodie, University of Cagliari, Italy.
Devoto
P
P
Gessa
G L
GL
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D017551:Microdialysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D000431:Ethanol