Short-term corticosteroid treatment does not improve implantation for embryos derived from subzonal insertion of sperm.
A total of 111 patients undergoing treatment for male factor infertility using SUZI participated in the trial for one treatment cycle only. They were allocated to have either corticosteroid treatment to induce immunosuppression or placebo. An elevated beta-hCG was found in 25% (9 of 36) of patients having an ET and receiving treatment. The corresponding figure for the control group was 33% (10 of 30). On ultrasound examination, fetal hearts were found in 22% (8 of 36) and 20% (6 of 30), respectively, of patients having an ET. chi 2 analysis showed no difference in the results. When the results were analyzed on a per oocyte basis there was no significant difference in the implantation rate.
Catt
J W
JW
Human Reproduction Unit, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Ryan
J P
JP
Saunders
D M
DM
O'Neill
C
C
D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D012189:Retrospective Studies; D013997:Time Factors; D015044:Zona Pellucida
D008775:Methylprednisolone