title: Filum terminale ependymoma revealed by acute cauda equina compression syndrome following intratumoral and spinal subarachnoid hemorrhage in a patient on oral anticoagulants.
abstract: A 65 year-old woman with a filum terminale ependymoma is reported, presenting with acute cauda equina compression syndrome due to intratumoural and subsequent spinal subarachnoid hemorrhage (SAH) following therapy with oral anticoagulants. Few cases of spinal ependymoma have been reported with an acute cauda equina compression syndrome as the initial and only symptom, and the unique feature of our patient's anticoagulant status has only been described once in this setting. Although intratumoural hemorrhage is very well known since the myxopapillary variant is unique to the cauda equina and consists of loose connective tissue and numerous small blood vessels that are prone to bleeding, spinal SAH is seldom seen and the different hypotheses about the pathophysiological mechanisms that might promote bleeding still remain unresolved and will be discussed in this paper, as well as the special clinical features of spinal SAH and some diagnostic and therapeutic implications. A review of the literature (Medline search 1983-1993) revealed only 13 cases, including ours, of spinal SAH due to cauda equina ependymoma, and the results of this review together with our findings are described in this paper.
authors.affiliation: Department of Neurology, Stuivenberg General Hospital, Antwerpen.
authors.forename: M L
authors.initials: ML
authors.lastname: Malbrain
authors.forename: A M
authors.initials: AM
authors.lastname: Kamper
authors.forename: G L
authors.initials: GL
authors.lastname: Lambrecht
authors.forename: P
authors.initials: P
authors.lastname: Hermans
authors.forename: E
authors.initials: E
authors.lastname: Baeck
authors.forename: F
authors.initials: F
authors.lastname: Verhoeven
authors.forename: G
authors.initials: G
authors.lastname: Wyffels
authors.forename: H
authors.initials: H
authors.lastname: Verbraeken
mesh_terms: D000208:Acute Disease; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D002420:Cauda Equina; D004806:Ependymoma / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000150:complications; D006801:Humans; D009408:Nerve Compression Syndromes / Q000209:etiology*; D010524:Peripheral Nervous System Neoplasms / Q000150:complications* / Q000175:diagnosis; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced* / Q000150:complications
chemical_list: D000925:Anticoagulants