title: [Acute anicteric hepatitis and intrahepatic cholestasis caused by administration of prajmalium bitartrate (Neo-Gilurytmal)].
abstract: The authors draw attention to a serious drug response to the derivative of the alkaloid ajmaline prajmalium (Neo-Gilurytmal, Giulini-GFR) which causes impairment of liver functions of various grades as a result of intrahepatic cholestasis. They draw attention to the necessity of a careful pharmacological case-history, evaluation of the premorbid stage, in particular former liver disease or contemporary administration of drugs which burden liver function (hormonal contraceptives, non-steroid antirheumatic drugs). It is essential to follow-up liver functions by laboratory tests already at the onset of treatment with Neo-Gilurytmal.
authors.affiliation: 1. interní klinika 2. LF UK, Praha.
authors.forename: J
authors.initials: J
authors.lastname: Trefanec
authors.forename: M
authors.initials: M
authors.lastname: Langmeierová
authors.forename: J
authors.initials: J
authors.lastname: Zelezná
mesh_terms: D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D006801:Humans; D008297:Male; D011219:Prajmaline / Q000009:adverse effects*
chemical_list: D011219:Prajmaline
vernacular_title: Akutní anikterická hepatitida s intrahepatální cholestázou vyvolaná podáváním prajmalium bitartarátu (Neo-Gilurytmal).