Granulomatous slack skin: cytogenetic and molecular analyses.
Granulomatous slack skin (GSS) is a rare disorder which is considered a slowly evolving T-cell lymphoma associated with granulomatous inflammation that mediates clastolysis. A combined cytogenetic, molecular, and cellular analysis was conducted on a clinically and histologically defined case of GSS. Cell cultures obtained from the skin biopsy showed trisomy of chromosome 8, and the DNA sample extracted from the skin biopsy showed a T-cell receptor beta-chain rearrangement.
Grammatico
P
P
Dipartimento di Medicina Sperimentale, Universita La Sapienza, Rome, Italy.
Balus
L
L
Scarpa
S
S
Varesco
L
L
Di Rosa
C
C
Grammatico
B
B
Del Porto
G
G
D000005:Abdomen; D002478:Cells, Cultured; D002898:Chromosomes, Human, Pair 8; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006099:Granuloma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology; D014314:Trisomy