The influence of radiotherapy and chemotherapy on regeneration at arterial microanastomoses: an experimental and clinical study.
The regeneration of anastomosed aortas after radiotherapy and chemotherapy was studied by light, scanning, and transmission electron microscopy in a rat model. At the ultrastructural level, it was observed that sublethal doses of these methods of cancer treatment did not severely block endothelial proliferation in the region of the microanastomosis. Based on the experimental results, myocutaneous free flap transfers were completed in patients with malignant tumors who had been undergoing radiotherapy and chemotherapy to cover defects resulting from their excision.
Sidorov
V B
VB
Department of Operative Surgery and Topographic Anatomy, Yaroslavl Medical Institute, Russia.
Minachenko
V K
VK
Rekhter
M D
MD
Pshenisnov
K P
KP
Mironov
A A
AA
Bauman
O A
OA
D000328:Adult; D000714:Anastomosis, Surgical; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001012:Aorta, Abdominal / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery; D003131:Combined Modality Therapy; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects* / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D013524:Surgical Flaps / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects* / Q000528:radiation effects*