title: [Immunologic isolation of transplanted islets of Langerhans: microcapsules with defined molecular limits].
abstract: Immunoisolated transplantation of islets of Langerhans in barium alginate microcapsules is a promising therapeutic approach to cure diabetes. An improved membrane for the coating of barium alginate microcapsules has been developed. Chemically stable barium alginate microcapsules with a controlled molecular weight cutoff between 9400 and 40,500 D were obtained after coating of barium alginate capsules in Polybrene solutions. Microcapsules prepared by this new method were still freely permeable to low molecular weight substances.
authors.affiliation: Lehrstuhl für Biotechnologie, Biozentrum der Universität Würzburg.
authors.forename: G
authors.initials: G
authors.lastname: Klöck
authors.forename: U
authors.initials: U
authors.lastname: Siebers
authors.forename: A
authors.initials: A
authors.lastname: Pfeffermann
authors.forename: J
authors.initials: J
authors.lastname: Schmitt
authors.forename: R
authors.initials: R
authors.lastname: Houben
authors.forename: K
authors.initials: K
authors.lastname: Federlin
authors.forename: U
authors.initials: U
authors.lastname: Zimmermann
mesh_terms: D000464:Alginates; D001464:Barium; D006801:Humans; D066298:In Vitro Techniques; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008567:Membranes, Artificial; D008970:Molecular Weight; D010539:Permeability
chemical_list: D000464:Alginates; D008567:Membranes, Artificial; D001464:Barium
vernacular_title: Immunisolation transplantierter Langerhansscher Inseln: Mikrokapseln mit definierter molekularer Ausschlussgrenze.