title: Improved sensitivity of colour Doppler flow imaging of colorectal hepatic metastases using galactose microparticles: a preliminary report.
abstract: The clinical application of ultrasonographic contrast agents in colour Doppler flow imaging of hepatic tumours is receiving increasing attention. Levovist is a suspension of galactose microparticles that provides reproducible concentrations of stabilized air bubbles with transpulmonary stability. Its effect on colour Doppler imaging was assessed in 26 patients with colorectal cancer and histologically proven hepatic metastases. Colour Doppler flow imaging was performed before and after intravenous injection of 10 ml Levovist 300 mg/ml. At 5-10 s after injection there was significant enhancement of the hepatic lesions with colour Doppler signals in 23 patients, lasting for a mean(s.d.) of 180(45) s. A consistent pattern of colour Doppler signal was observed, with increased enhancement predominantly around the tumour periphery and little or no central enhancement. These data suggest that Levovist may increase the sensitivity and specificity of colour Doppler flow imaging of colorectal hepatic metastases.
authors.affiliation: Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: E
authors.initials: E
authors.lastname: Leen
authors.forename: W J
authors.initials: WJ
authors.lastname: Angerson
authors.forename: H W
authors.initials: HW
authors.lastname: Warren
authors.forename: P
authors.initials: P
authors.lastname: O'Gorman
authors.forename: B
authors.initials: B
authors.lastname: Moule
authors.forename: E C
authors.initials: EC
authors.lastname: Carter
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000328:Adult; D000368:Aged; D003116:Color; D015179:Colorectal Neoplasms; D003287:Contrast Media; D006801:Humans; D008099:Liver / Q000098:blood supply; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000556:secondary*; D008875:Middle Aged; D011134:Polysaccharides; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508