Entropy in biological binding processes: estimation of translational entropy loss.
The loss of translational degrees of freedom makes an important, unfavorable contribution to the free energy of binding. Examination of experimental values suggest that calculation of this entropy using the Sackur-Tetrode equation produces largely overestimated values. Better agreement is obtained using the cratic entropy. Theoretical considerations suggest that the volumes available for the movement of a ligand in solution and in a complex are rather similar, suggesting also that the cratic entropy provides the best estimate of the loss of translational entropy.
Murphy
K P
KP
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218.
Xie
D
D
Thompson
K S
KS
Amzel
L M
LM
Freire
E
E
D000804:Angiotensin II / Q000737:chemistry / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000737:chemistry; D004268:DNA-Binding Proteins; D004151:Dipeptides / Q000737:chemistry; D005656:Fungal Proteins / Q000737:chemistry; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D011494:Protein Kinases / Q000737:chemistry; D029701:Saccharomyces cerevisiae Proteins; D013816:Thermodynamics
D000911:Antibodies, Monoclonal; D004268:DNA-Binding Proteins; D004151:Dipeptides; D005656:Fungal Proteins; D010456:Peptides, Cyclic; D029701:Saccharomyces cerevisiae Proteins; D000804:Angiotensin II; D011494:Protein Kinases