title: Migraine: possible role of platelet insensitivity to prostaglandin E1 (PGE1).
abstract: Platelet aggregation inhibition, induced by prostaglandin E1 (PGE1), was evaluated in 38 patients affected by migraine. Our data indicate a complete insensitivity to PGE1 in these subjects. The insensitivity to PGE1 leads to decreased cyclic-AMP (cAMP) levels, determining an imbalance in the inhibitory mechanism. From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.
authors.affiliation: Clinical Pathology Laboratory Haemostasis Service, Pediatric Hospital Burlo Garofolo, Trieste, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cerneca
authors.forename: S
authors.initials: S
authors.lastname: de Luyk
authors.forename: O
authors.initials: O
authors.lastname: Radillo
authors.forename: R
authors.initials: R
authors.lastname: Simeone
authors.forename: M
authors.initials: M
authors.lastname: Mangiarotti
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000494:pharmacology* / Q000502:physiology; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002648:Child; D000242:Cyclic AMP / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values
chemical_list: D000244:Adenosine Diphosphate; D000242:Cyclic AMP; D000527:Alprostadil