[Malignant hyperthermia in swine: a study of atracurium in MH-susceptible swine].
Since muscle relaxants have been implicated in triggering malignant hyperthermia (MH) in MH-susceptible humans and animals, the potential of new muscle relaxants for triggering MH needs to be assessed in vivo in MH-susceptible pigs. The triggering potential of atracurium was evaluated in six MH-susceptible pigs during one hour infusion of a 90% blocking dose (0.4 mg/kg/h) of atracurium. The mean recovery time (25% to 75%) was 10.2 min and a slight increase in heart rate (142 to 170 beats per minute) was observed. Rectal temperature decreased slightly (36.4 to 35.6 degrees C) and end tidal CO2 was stable at 5.46 kpa. In this study atracurium did not trigger MH in susceptible pigs.
Williams
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C
Abteilungen für Anästhesiologie und Biochemie des Texas Tech University Health Sciences Center, El Paso, Texas.
Dozier
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S
Ilias
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W
Fulfer
R
R
D000818:Animals; D001279:Atracurium / Q000009:adverse effects*; D004198:Disease Susceptibility; D008305:Malignant Hyperthermia / Q000209:etiology*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced*
D001279:Atracurium
Maligne Hyperthermie des Schweines: Untersuchung von Atracurium an MH-empfindlichen Schweinen.