title: Crystal structure of the ribosomal protein S6 from Thermus thermophilus.
abstract: The amino acid sequence and crystal structure of the ribosomal protein S6 from the small ribosomal subunit of Thermus thermophilus have been determined. S6 is a small protein with 101 amino acid residues. The 3D structure, which was determined to 2.0 A resolution, consists of a four-stranded anti-parallel beta-sheet with two alpha-helices packed on one side. Similar folding patterns have been observed for other ribosomal proteins and may suggest an original RNA-interacting motif. Related topologies are also found in several other nucleic acid-interacting proteins and based on the assumption that the structure of the ribosome was established early in the molecular evolution, the possibility that an ancestral RNA-interacting motif in ribosomal proteins is the evolutionary origin for the nucleic acid-interacting domain in large classes of ribonucleic acid binding proteins should be considered.
authors.affiliation: Chemical Center, University of Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lindahl
authors.forename: L A
authors.initials: LA
authors.lastname: Svensson
authors.forename: A
authors.initials: A
authors.lastname: Liljas
authors.forename: S E
authors.initials: SE
authors.lastname: Sedelnikova
authors.forename: I A
authors.initials: IA
authors.lastname: Eliseikina
authors.forename: N P
authors.initials: NP
authors.lastname: Fomenkova
authors.forename: N
authors.initials: N
authors.lastname: Nevskaya
authors.forename: S V
authors.initials: SV
authors.lastname: Nikonov
authors.forename: M B
authors.initials: MB
authors.lastname: Garber
authors.forename: T A
authors.initials: TA
authors.lastname: Muranova
mesh_terms: D000595:Amino Acid Sequence; D003196:Computer Graphics; D018360:Crystallography, X-Ray; D008969:Molecular Sequence Data; D011487:Protein Conformation; D038601:Ribosomal Protein S6; D012269:Ribosomal Proteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D016963:Thermus thermophilus / Q000737:chemistry*
chemical_list: D038601:Ribosomal Protein S6; D012269:Ribosomal Proteins