The release of oxytocin from spinal cord synaptosomes by high KCl depolarizing stimulus: a calcium dependent process.
Oxytocin (OT) release from synaptosomes isolated from the thoracic (T) and lumbosacral (LS) regions of the spinal cord was evoked by 56 mM potassium chloride (KCl). The release mechanism was shown to be a calcium dependent process. The ability of high KCl to evoke OT release from isolated nerve terminals in a calcium dependent manner provides additional support for the role of OT as a neurotransmitter in the spinal cord.
Daddona
M M
MM
Department of Biological Sciences, St. John's University, Jamaica, New York 11439.
Haldar
J
J
D000818:Animals; D002118:Calcium / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D010121:Oxytocin; D011189:Potassium Chloride; D002118:Calcium