title: Anti-rotavirus G type-specific and isotype-specific antibodies in children with natural rotavirus infections.
abstract: Serum VP7 (G) type- and isotype-specific anti-rotavirus antibodies were assessed among children monitored longitudinally over one or two rotavirus seasons in day care centers. Seventy-five pairs of blood specimens from 63 children were tested for anti-rotavirus antibodies. Stool specimens were collected weekly and tested for rotavirus antigen. G typing of detected rotaviruses showed that seven outbreaks of G1 and one of G3 occurred during the two seasons. G type-specific responses to the outbreak strain occurred among 79% of infected children and 9% of children with infection not detected (P < .001). Of children infected with G1, 54% had a heterotypic response; they were older (P = .048) and had higher preexisting G1 antibody levels than children who had only homotypic responses (P = .012). Higher IgA, IgG, and homotypic antibody levels to the antigenic site C of the G1 and G3 VP7s correlated with protection against infection and illness, homotypic antibody independently of IgA or IgG titers.
authors.affiliation: Division of Pediatric Infectious Diseases, University of Texas Medical School, Houston.
authors.forename: M L
authors.initials: ML
authors.lastname: O'Ryan
authors.forename: D O
authors.initials: DO
authors.lastname: Matson
authors.forename: M K
authors.initials: MK
authors.lastname: Estes
authors.forename: L K
authors.initials: LK
authors.lastname: Pickering
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D002656:Child Day Care Centers; D004196:Disease Outbreaks; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007132:Immunoglobulin Isotypes; D007223:Infant; D007231:Infant, Newborn; D012401:Rotavirus / Q000145:classification / Q000276:immunology; D012400:Rotavirus Infections / Q000453:epidemiology / Q000276:immunology*; D012703:Serotyping; D013781:Texas / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes