Comparative analysis of the T cell receptor V beta repertoire in various lymphoid tissues from HIV-infected patients: evidence for an HIV-associated superantigen.
The search to identify HIV-associated molecules with superantigenic properties has focussed on demonstration of T cell receptor V beta subset-specific perturbations in HIV-infected patients. In this report, the V beta repertoire of two HIV patients was studied in lymph nodes, where HIV-1 replication is the most intense, and compared to the repertoire found in peripheral blood. Use of this fully MHC-compatible system has allowed identification of a small, partly overlapping set of V beta determinants which appear significantly perturbed in HIV-1 infection. These results are consistent with the presence of an HIV-associated superantigen.
Soudeyns
H
H
Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montréal, Québec, Canada.
Routy
J P
JP
Sékaly
R P
RP
D000328:Adult; D002478:Cells, Cultured; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D008297:Male; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis*; D018089:Superantigens / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens