Serum coenzyme Q10 in uremic patients on chronic hemodialysis.
In a group of 48 chronic hemodialysis patients, serum levels of coenzyme Q10 (CoQ) have been measured and appeared abnormally low in 62% of cases. Figures were positively correlated to those of serum vitamin E (vit E), although the latter were within a normal range. The chronic hemodialysis (CHD) patients with normal serum values of CoQ exhibited higher blood triglycerides. Pathologically low levels of serum vit E were found only in uremic subjects on conservative regimen with dietary restrictions and low compliance to protein-caloric intake. The reduced CoQ levels may contribute to the defective serum antioxidant activity and the increased peroxidative damage in uremic patients on CHD.
Triolo
L
L
Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma, Italia.
Lippa
S
S
Oradei
A
A
De Sole
P
P
Mori
R
R
D000368:Aged; D002784:Cholesterol / Q000097:blood; D003067:Coenzymes; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014511:Uremia / Q000097:blood / Q000201:enzymology*; D014810:Vitamin E / Q000097:blood
D003067:Coenzymes; D014280:Triglycerides; D014451:Ubiquinone; D014810:Vitamin E; D002784:Cholesterol; C024989:coenzyme Q10