title: Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response.
abstract: OBJECTIVE
  The present study was undertaken to investigate the relationship between thiamin intake and its biochemical status in 60 free-living (30 male, 30 female) elderly subjects (> or = 65 years).
  
  
  METHODS
  Dietary intake was estimated using a 3-nonconsecutive-day food record. Biochemical status was assessed by measuring the stimulating effect of thiamin pyrophosphate (TPP) on transketolase activity (TPP effect) in hemolyzed erythrocytes, which is a functional test indicative of metabolic availability of thiamin.
  
  
  RESULTS
  Average daily thiamin intake was above the recommended requirement (> 0.4 mg/1000 Kcal) for each gender; however, almost half of the total study population had TPP effect > 14%, suggesting thiamin deficiency. There was no correlation between thiamin intake and TPP effect.
  
  
  CONCLUSIONS
  These findings raise questions about the reliability of dietary intake in assessing metabolic availability of thiamin in the elderly.
authors.affiliation: Department of Food Science and Nutrition, University of Alberta, Edmonton, Canada.
authors.forename: H K
authors.initials: HK
authors.lastname: Nichols
authors.forename: T K
authors.initials: TK
authors.lastname: Basu
mesh_terms: D000368:Aged; D000375:Aging; D001682:Biological Availability; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status; D013831:Thiamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*; D014174:Transketolase / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D014174:Transketolase; D013835:Thiamine Pyrophosphate; D013831:Thiamine