title: [Skin lesions as a rare initial symptom of Kahler's disease].
abstract: Multiple skin lesions developed in a 70 year-old-man. Pathological examination revealed plasmacytomas. Because of the presence of a IgD paraprotein and 15% abnormal plasma cells in the bone marrow Kahler's disease of the IgD type was diagnosed. In accordance with literature the course of the disease was rapidly progressive. After an initial favourable response to chemotherapy and radiotherapy, the patient died one year after diagnosis. Extraosseous tissue involvement and hepatosplenomegaly are well-known phenomenon of IgD-Kahler's disease. Skin plasmacytomas as the first symptom of the disease are very rare.
authors.affiliation: Locatie Lukas Ziekenhuis, afd. Inwendige Geneeskunde, Ziekenhuis Centrum Apeldoorn.
authors.forename: K M
authors.initials: KM
authors.lastname: van Tol
authors.forename: G
authors.initials: G
authors.lastname: Fedder
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011241:Prednisone / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
chemical_list: D008558:Melphalan; D011241:Prednisone
vernacular_title: Huidafwijkingen als zeldzaam eerste symptoom van de ziekte van Kahler.