title: Effect of nitrous oxide and volatile anaesthetics on platelet function in man.
abstract: Twelve otherwise healthy male volunteers scheduled for arthroscopy of the knee were studied. The influence in vivo of nitrous oxide (N2O) per se and the addition of a halogenated volatile anaesthetic (halothane or isoflurane) on ADP-induced platelet aggregation and release of beta-thromboglobulin into plasma was evaluated. All measurements were made before surgery. We found that N2O increased platelet aggregation. Adding a halogenated anaesthetic reversed the relative hyperaggregation induced by N2O. The concentrations in plasma of the platelet release product beta thromboglobulin were not influenced by the anaesthetics.
authors.affiliation: Department of Anaesthesia, Gentofte Hospital, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Nygård
authors.forename: O
authors.initials: O
authors.lastname: Naesh
authors.forename: I
authors.initials: I
authors.lastname: Hindberg
authors.forename: N
authors.initials: N
authors.lastname: Valentin
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D006221:Halothane; D006801:Humans; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D001620:beta-Thromboglobulin / Q000378:metabolism*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001620:beta-Thromboglobulin; D007530:Isoflurane; D009609:Nitrous Oxide; D006221:Halothane