[Poor results of treatment of echinococcosis with albendazole in 7 patients].
OBJECTIVE
To assess the effect of treatment of echinococcal disease with albendazole, a drug recently licensed in the Netherlands for this treatment.


METHODS
The University Hospital Utrecht and the Wilhelmina Children's Hospital, Utrecht.


METHODS
Follow-up study.


METHODS
Clinical symptoms, serology and size and morphology of cysts of all patients (n = 7) treated with albendazole with a therapeutical dose (10 mg/kg for adults and 6 mg/kg for children in two daily doses during three cycles of 28 days) were monitored for at least one year.


RESULTS
Two patients improved, two patients did not show any change, and the condition of three patients deteriorated.


CONCLUSIONS
The efficacy of albendazole treatment with this regimen for hydatid disease is disappointing. If patients are treated with albendazole, the total dose administered to adults should be more than 80 g.
Schneeberger
P M
PM
Academisch Ziekenhuis, Eijkman-Winkler Laboratorium voor Medische Microbiologie, Utrecht.
Kortbeek
L M
LM
Schneider
M M
MM
Geelen
S P
SP
van Leeuwen
M S
MS
Hoepelman
I M
IM
D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000601:surgery; D004445:Echinococcosis, Pulmonary / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure
D015766:Albendazole
Matig resultaat van behandeling van echinokokkose met albendazol bij 7 patiënten.