title: [Kaposi-Irgang lupus erythematosus profundus. Lupus erythematosus panniculitis].
abstract: Lupus panniculitis is a rare variant of cutaneous lupus erythematosus. Two typical cases demonstrate the association of lupus panniculitis with signs of discoid lupus erythematosus and systemic lupus erythematosus. Clinically it is characterised by subcutaneous nodules or plaques, which may ulcerate leaving depressed atrophic scars. Histologically the lesions show lobular panniculitis. A positive immunofluorescent band test with deposition of IgG, IgM and C3 at the dermal-epidermal junction and blood vessel walls helps to confirm the diagnosis. The knowledge of the clinical features and histopathology of the disease is important because lupus panniculitis may precede systemic lupus erythematosus by some years.
authors.affiliation: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
authors.forename: R
authors.initials: R
authors.lastname: Süss
authors.forename: M
authors.initials: M
authors.lastname: Meurer
authors.forename: C G
authors.initials: CG
authors.lastname: Schirren
authors.forename: S
authors.initials: S
authors.lastname: Lübke
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D001379:Azathioprine / Q000008:administration & dosage; D001485:Basement Membrane / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D003238:Connective Tissue / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005355:Fibrosis; D005455:Fluorescent Antibody Technique; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D015435:Panniculitis, Lupus Erythematosus / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D003176:Complement C3; D005938:Glucocorticoids; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D001379:Azathioprine
vernacular_title: Lupus erythematodes profundus Kaposi-Irgang. Lupus erythematosus panniculitis.