title: Non-melanoma skin cancer in renal transplant recipients: the extent of the problem and a strategy for management.
abstract: Over the past 2 years, we have examined all patients with a functioning renal allograft attending a regional nephrology unit. A total of 291 patients were examined. 172 (59%) were found to have cutaneous warts, and 64 (21.9%) had non-melanoma skin cancer (NMSC). The proportion of patients with both warts and NMSC increased with time from transplantation: 40% of patients who had been transplanted for more than 9 years had NMSC. Fifteen patients had extensive dysplastic change in all sun-exposed areas, particularly the dorsal aspect of the hands. This subgroup of patients develop large numbers of tumours, particularly squamous cell carcinomas (SCC), and require close surveillance and frequent surgery. One patient has died as a result of rapidly evolving metastases from an SCC on the dorsum of the hand. Excision and grafting of the backs of the hands in four patients, and long term etretinate therapy in 6 patients have led to a marked reduction in the frequency of surgery to remove tumours. The very high rate of NMSC, frequently multiple, found in this study of UK residents is a source of concern and indicates the need for close dermatological monitoring of allograft recipients, with intensive surveillance of patients with extensive dysplasia, who may develop tumours requiring surgery every few weeks.
authors.affiliation: Department of Dermatology, Royal London Hospital NHS Trust.
authors.forename: M T
authors.initials: MT
authors.lastname: Glover
authors.forename: N
authors.initials: N
authors.lastname: Niranjan
authors.forename: J T
authors.initials: JT
authors.lastname: Kwan
authors.forename: I M
authors.initials: IM
authors.lastname: Leigh
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000628:therapy; D005050:Etretinate / Q000627:therapeutic use; D006225:Hand; D006229:Hand Dermatoses / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009333:Neck; D012871:Skin Diseases / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology* / Q000628:therapy; D013997:Time Factors; D014860:Warts / Q000209:etiology*
chemical_list: D005050:Etretinate