title: Multigene families in African swine fever virus: family 505.
abstract: Sequencing of restriction fragment EcoRI A-SalI C of African swine fever virus has revealed the existence of a multigene family, designated family 505 because of the average number of amino acids in the proteins, composed of seven homologous and tandemly arranged genes. All the genes of family 505 are expressed during infection. Primer extension analysis showed that transcription is initiated a short distance (3 to 62 nucleotides) from the start codon of the corresponding open reading frame. The proteins of family 505 showed similarity to those of family 360 from African swine fever virus. In particular, a striking conservation of three regions at the amino terminus of the polypeptides was observed.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Facultad de Ciencias, Cantoblanco, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodriguez
authors.forename: R J
authors.initials: RJ
authors.lastname: Yañez
authors.forename: R
authors.initials: R
authors.lastname: Pan
authors.forename: J F
authors.initials: JF
authors.lastname: Rodriguez
authors.forename: M L
authors.initials: ML
authors.lastname: Salas
authors.forename: E
authors.initials: E
authors.lastname: Viñuela
mesh_terms: D000358:African Swine Fever Virus / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014709:Vero Cells
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger