title: Synthesis and antiviral activity of some new benzofuran derivatives.
abstract: New derivatives of benzofuran were prepared and evaluated for their in vitro activity against a number of DNA and RNA viruses in various cell systems. Compounds 1-(7-dodecyloxy-2-benzofuranyl)ethanone (3c) and 1-(7-tridecyloxy-2-benzofuranyl)ethanone (3d) exhibited a specific activity against respiratory syncytial virus in HeLa and compound [di(2-acetylbenzofuranyl-7-oxy)]-n-propane (5a) against influenza A virus in MDCK.
authors.affiliation: Department of Pharmacy, University of Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Papadaki-Valiraki
authors.forename: O
authors.initials: O
authors.lastname: Todoulou
authors.forename: E
authors.initials: E
authors.lastname: Filippatos
authors.forename: A
authors.initials: A
authors.lastname: Tsotinis
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004267:DNA Viruses / Q000187:drug effects*; D000882:Haplorhini; D006367:HeLa Cells; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D001572:Benzofurans