Possible implications of CpG avoidance in the flatworm Schistosoma mansoni.
We report the analysis of the biases of CpG, TpG, and CpA of all the DNA sequences data from the Trematode Schistosoma mansoni. Our results show CpG avoidance whereas TpG and CpA frequencies are over the expected values. These characteristics are similar to the biases displayed by methylated genomes, but in platyhelminths 5mC has not been detected by biochemical methods. The possible implications of this CpG shortage are discussed.
Musto
H
H
Departamento de Bioquímica, Facultad de Ciencias, Montevideo, Uruguay.
Rodríguez-Maseda
H
H
Alvarez
F
F
Tort
J
J
D000818:Animals; D001482:Base Composition; D004247:DNA / Q000235:genetics*; D004275:DNA, Ribosomal / Q000235:genetics; D015226:Dinucleoside Phosphates / Q000235:genetics*; D007438:Introns; D014176:Protein Biosynthesis; D012091:Repetitive Sequences, Nucleic Acid; D012550:Schistosoma mansoni / Q000235:genetics*
D004247:DNA; D004275:DNA, Ribosomal; D015226:Dinucleoside Phosphates; C015772:CpG dinucleotide; C013907:cytidylyl adenosine