Actions of interleukin-2 on amnion prostaglandin biosynthesis.
Preterm labor is associated with increased intrauterine prostaglandin (PG) production. Intrauterine infections are frequently associated with preterm labor and increased cytokine production. The cytokine interleukin-2 (IL-2) is a potent T-cell growth factor necessary for effective cell-mediated immunity. In this study we evaluated the effects of IL-2 on PGE2 biosynthesis by human amnion cells. IL-2 alone modestly but significantly inhibited amnion PGE2 production. Moreover, IL-2 also attenuated, in a concentration-related fashion, the stimulatory actions of IL-1 beta on PGE2 production by amnion cells. These data suggest that IL-2 could potentially represent a negative regulatory element in the mechanisms of preterm labor in association with intrauterine infection.
Coulam
C H
CH
Department of Obstetrics & Gynecology, University of Utah School of Medicine, Salt Lake City 84132.
Edwin
S S
SS
LaMarche
S
S
Mitchell
M D
MD
D000650:Amnion / Q000187:drug effects* / Q000378:metabolism*; D001424:Bacterial Infections / Q000150:complications / Q000378:metabolism; D015232:Dinoprostone / Q000096:biosynthesis*; D005246:Feedback; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D007752:Obstetric Labor, Premature / Q000209:etiology / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism
D007376:Interleukin-2; D015232:Dinoprostone