Four new C16 1,2-dioxene-polyketides from the sponge Plakortis aff. simplex.
Two new cyclic peroxide-containing polyketide C16 acids 2 and 4 with their methyl esters 3 and 5 have been isolated from the Indo-Pacific marine sponge Plakortis aff. simplex. Both 2 and 3 are proposed to contain a single 1,2-dioxene ring, while 4 and 5 incorporate two 1,2-dioxene rings. The structures were elucidated mainly through 1D and 2D nmr spectral analysis. The methyl esters 3 and 5 were found to be active against cultured P-388 murine leukemia cells.
Rudi
A
A
Department of Zoology, Tel Aviv University, Israel.
Talpir
R
R
Kashman
Y
Y
Benayahu
Y
Y
Schleyer
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones