title: [Nocturnal spasmodic cough in the infant. Evolution after antireflux treatment].
abstract: Several studies have shown the relationship between gastro-oesophageal reflux, bronchial asthma and chronic nocturnal cough and this should not be neglected, particularly in patients who present an unfavourable development in spite of conventional treatment. For diagnosis of gastroesophageal reflux, amongst other investigations, esophageal gammagraphy of swallowing, that detects alterations in the mobility of the oesophagus, secondary to a possible oesophagitis. The objective of this study was to evaluate the clinical progress and gammagraphy of a group of children with chronic predominantly nocturnal cough (with or without bronchial asthma) with initially pathological esophageal gammagraphy, after three months of treatment with gastrokinetic drugs (cisapride against domperidone) and postural dietetic limits, in comparison with a reference group who, although having followed the limits in question had not received the pharmacological treatment. From the clinical viewpoint, cough disappeared in 64.5% of cases without significant statistical differences between the two groups. Gammagraphy became normal in 20/55 cases, improved in 10/55 cases and was unchanged in 25/55. Although there was no significant difference, gammagraphy development was better in children who received domperidone. The agreement between clinical progress and gammagraphy was 60% with a large number of false positives in the gammagraphy. We believe that the simple introduction of the postural-dietetic measures may improve the clinical control in the type of patients who present with a chronic nocturnally predominant cough that does not yield to conventional treatment.
authors.affiliation: Service d'Allergologie et d'Immunologie Clinique, Hôpital pour enfants et Maternité Vall d'Hebrón, Barcelone, Espagne.
authors.forename: M T
authors.initials: MT
authors.lastname: Dordal
authors.forename: M A
authors.initials: MA
authors.lastname: Baltazar
authors.forename: I
authors.initials: I
authors.lastname: Roca
authors.forename: L
authors.initials: L
authors.lastname: Marques
authors.forename: M T
authors.initials: MT
authors.lastname: Server
authors.forename: J
authors.initials: J
authors.lastname: Botoy
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D003371:Cough / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004294:Domperidone / Q000627:therapeutic use*; D005260:Female; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D010880:Piperidines / Q000627:therapeutic use; D011446:Prospective Studies; D011877:Radionuclide Imaging
chemical_list: D010880:Piperidines; D004294:Domperidone; D020117:Cisapride
vernacular_title: Toux spasmodique nocturne chez l'enfant. Evolution après traitement antireflux.