title: Relapse of acute lymphoblastic leukemia in the inferior rectus muscle of the eye.
abstract: BACKGROUND
  Extramedullary involvement of acute lymphoblastic leukemia (ALL) in sites outside the central nervous system (CNS) or testes is rare and may signal a refractory form of leukemia.
  
  
  METHODS
  The authors describe a child with ALL who experienced a relapse involving the inferior rectus muscle of the eye. This patient had been treated with a bone marrow transplant for previous bone marrow and ovarian relapse.
  
  
  RESULTS
  The patients had a pre-B ALL with a t(1;19) chromosomal translocation and previously had experienced relapse during therapy. At the time of the muscle relapse, she had pancreatomegaly consistent with leukemic infiltration but no CNS or bone marrow disease.
  
  
  CONCLUSIONS
  Relapse of ALL in unusual sites may indicate disease that is particularly difficult to eradicate. Factors in addition to age and leukocyte count at diagnosis determined risk. Additional research is needed to define these factors and develop more effective therapy.
authors.affiliation: Department of Hematology/Oncology, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010.
authors.forename: A S
authors.initials: AS
authors.lastname: Hinkle
authors.forename: P A
authors.initials: PA
authors.lastname: Dinndorf
authors.forename: D I
authors.initials: DI
authors.lastname: Bulas
authors.forename: S
authors.initials: S
authors.lastname: Kapur
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D017254:Leukemic Infiltration / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009801:Oculomotor Muscles / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D010179:Pancreas / Q000473:pathology; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*