Phenothiazine treatment and respiratory distress syndrome in a child.
An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome. He required intensive treatment and support for 13 days. The persistent effects of methotrimeprazine meleate on various organs are typical of the prolonged biological action of the phenothiazine metabolites. The association of phenothiazine overdose and respiratory distress syndrome merits consideration.
Eshel
G
G
Assaf Harofeh Medical Center, Zerifin, Israel.
Usher
M
M
Barr
J
J
Heggesh
R
R
Lahat
E
E
D002648:Child; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000378:metabolism; D006801:Humans; D008297:Male; D008728:Methotrimeprazine / Q000506:poisoning* / Q000627:therapeutic use*; D019964:Mood Disorders / Q000188:drug therapy; D012120:Respiration Disorders / Q000139:chemically induced*
D008728:Methotrimeprazine