title: Intracytoplasmic lumina in a case of bilaterally multifocal renal oncocytomas.
abstract: We report a case of bilaterally multifocal renal oncocytomas in a patient with chronic renal disease and a long history of hypertension. Histologic study of the multiple oncocytic neoplasms with hematoxylin-eosin, periodic acid-Schiff, trichrome, and colloidal iron stains revealed novel, intracytoplasmic lumina, which were accentuated by immunoperoxidase staining with high-molecular-weight cytokeratin, epithelial membrane antigen, and Arachis hypogaea lectin. Ultrastructural studies demonstrated multiple microvilli lining the intracytoplasmic lumina. We also review the literature on bilaterally multifocal oncocytomas.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston.
authors.forename: J S
authors.initials: JS
authors.lastname: Lyzak
authors.forename: A
authors.initials: A
authors.lastname: Farhood
authors.forename: R
authors.initials: R
authors.lastname: Verani
mesh_terms: D018249:Adenoma, Oxyphilic / Q000150:complications / Q000473:pathology*; D000328:Adult; D003593:Cytoplasm / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000150:complications / Q000473:pathology*; D008854:Microscopy, Electron