title: Prognostic significance of estrogen receptor expression in ovarian cancer. Immunoreactive Score (IRS) vs. Composition Adjusted Receptor Level (CARL).
abstract: An Immunoreactive Score (IRS) was compared to the Composition Adjusted Receptor Level (CARL) evaluating prognostic significance of estrogen receptor (ER) expression in 61 ovarian cancers after > or = 8 years. CARL of ER allowed for calculating individual risk curves in stage III and IV, Grade 2 and 3, serous ovarian carcinoma after surgical debulking to < or = 2 cm residual and platinum based chemotherapy. In overall analysis and in subsets defined by tumor stage, grade or a combination thereof significant prognostic distinction became possible using a cutoff IRS of 4 vs. 0 or vs. scores < or = 3. This study substantiates ER as a prognostic variable in human ovarian cancer and for the first time establishes the value of an IRS.
authors.affiliation: Department of Obstetrics & Gynecology, University of Ulm, Germany.
authors.forename: D G
authors.initials: DG
authors.lastname: Kieback
authors.forename: M F
authors.initials: MF
authors.lastname: Press
authors.forename: E N
authors.initials: EN
authors.lastname: Atkinson
authors.forename: G L
authors.initials: GL
authors.lastname: Edwards
authors.forename: V J
authors.initials: VJ
authors.lastname: Möbus
authors.forename: I B
authors.initials: IB
authors.lastname: Runnebaum
authors.forename: R
authors.initials: R
authors.lastname: Kreienberg
authors.forename: L A
authors.initials: LA
authors.lastname: Jones
mesh_terms: D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D016019:Survival Analysis
chemical_list: D011960:Receptors, Estrogen