title: Lipoprotein(a) in restenosis after percutaneous transluminal coronary angioplasty and coronary artery disease.
abstract: BACKGROUND
  The purpose of the study was to investigate the relation of lipoprotein(a) and serum lipid parameters to restenosis after percutaneous transluminal coronary angioplasty (PTCA) and to assess the association of these same biochemical markers to coronary artery disease (CAD) in individuals with angiographically defined normal and diseased coronary arteries.
  
  
  RESULTS
  Sixty-two patients with successful PTCA had follow-up angiography at 35 +/- 10 weeks. Restenosis occurred in 21 male patients (46%) and 6 female patients (38%). Elevated apolipoprotein B (P < .01) and decreased high-density lipoprotein-2 cholesterol (P < .02) were found to be independently associated with restenosis after angioplasty, whereas lipoprotein(a) was not. Eighty-five patients undergoing PTCA were compared with 46 subjects who had no evidence of CAD on angiography. Elevated lipoprotein(a) (P < .001) and reduced apolipoprotein A1 to B ratio (P < .001) were found to be strong independent risk factors for the presence of CAD when adjustment was made for age (P < .005), male sex (P < .01), smoking (P < .005), and hypertension (P = .06).
  
  
  CONCLUSIONS
  Serum lipoprotein(a) levels are not associated with restenosis after PTCA, but elevated levels are strongly associated with CAD. Low-serum, high-density lipoprotein-2 cholesterol concentration and elevated apolipoprotein B concentration were found to be associated with restenosis after PTCA.
authors.affiliation: Department of Biological Sciences, Dublin Institute of Technology, Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Cooke
authors.forename: R
authors.initials: R
authors.lastname: Sheahan
authors.forename: D
authors.initials: D
authors.lastname: Foley
authors.forename: M
authors.initials: M
authors.lastname: Reilly
authors.forename: G
authors.initials: G
authors.lastname: D'Arcy
authors.forename: W
authors.initials: W
authors.lastname: Jauch
authors.forename: M
authors.initials: M
authors.lastname: Gibney
authors.forename: G
authors.initials: G
authors.lastname: Gearty
authors.forename: P
authors.initials: P
authors.lastname: Crean
authors.forename: M
authors.initials: M
authors.lastname: Walsh
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001053:Apolipoproteins / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D003251:Constriction, Pathologic / Q000097:blood / Q000453:epidemiology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001053:Apolipoproteins; D008076:Cholesterol, HDL; D017270:Lipoprotein(a)