title: Mechanism of eosinophil infiltration in the patient with subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura's disease). Mechanism of eosinophil chemotaxis mediated by candida antigen and IL-5.
abstract: Kimura's disease is a chronic granulomatous disease of unknown etiology. Although eosinophilia is one of the characteristic features in this disease, little is known about the mechanism of eosinophilia. In the present study it was demonstrated that interleukin-5 (IL-5) was produced and released from the site of a granuloma and lymph nodes after stimulation with candida antigen. It was also shown that peripheral blood eosinophils from patients with Kimura's disease contained a large proportion of hypodense eosinophils and that their viability was prolonged. These results strongly suggest that locally produced IL-5 induced by candida antigen contributes to the eosinophilia in this disease.
authors.affiliation: Department of Otorhinolaryngology, Akita University, School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Terada
authors.forename: A
authors.initials: A
authors.lastname: Konno
authors.forename: K
authors.initials: K
authors.lastname: Shirotori
authors.forename: T
authors.initials: T
authors.lastname: Fujisawa
authors.forename: J
authors.initials: J
authors.lastname: Atsuta
authors.forename: R
authors.initials: R
authors.lastname: Ichimi
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Takaki
authors.forename: K
authors.initials: K
authors.lastname: Takatsu
authors.forename: K
authors.initials: K
authors.lastname: Togawa
mesh_terms: D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000097:blood* / Q000209:etiology; D000946:Antigens, Fungal / Q000494:pharmacology*; D002175:Candida / Q000276:immunology*; D002631:Chemotactic Factors, Eosinophil / Q000009:adverse effects / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects*; D004802:Eosinophilia / Q000150:complications / Q000503:physiopathology; D004804:Eosinophils / Q000473:pathology*; D006099:Granuloma / Q000378:metabolism; D006801:Humans; D015848:Interleukin-5 / Q000378:metabolism / Q000494:pharmacology*; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male
chemical_list: D000946:Antigens, Fungal; D002631:Chemotactic Factors, Eosinophil; D015848:Interleukin-5