[Synthesis of protected active peptide analogues of cholecystokinin and study of their biological activities].
A number of protected active peptide analogues of Cholecystokinin were prepared in solution by N-end stretching method with active esters. In the synthesis t-butoxycarbonyl (Boc-) and benzyloxycarbonyl (Z-) were applied as protecting groups. Six oligopeptides which contained protecting groups have not yet been reported in literature. Their structures were identified by amino acid analysis, opticity, IR and FAB-MS. The results of preliminary pharmacological tests show all the samples have biological activities in various degrees.
Guo
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Weng
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D000595:Amino Acid Sequence; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D009842:Oligopeptides; D012844:Sincalide / Q000138:chemical synthesis* / Q000737:chemistry
D009842:Oligopeptides; D002766:Cholecystokinin; D012844:Sincalide