Autism in thalidomide embryopathy: a population study.
Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism. Thalidomide embryopathy of the kind encountered in these cases affects fetal development early in pregnancy, probably on days 20 to 24 after conception. It is argued that the possible association of thalidomide embryopathy with autism may shed some light on the issue of which neural circuitries may be involved in autism pathogenesis.
Strömland
K
K
Department of Ophthalmology, University of Göteborg, Sweden.
Nordin
V
V
Miller
M
M
Akerström
B
B
Gillberg
C
C
D000328:Adult; D001321:Autistic Disorder / Q000139:chemically induced* / Q000175:diagnosis; D003638:Deafness / Q000139:chemically induced; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000139:chemically induced; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013792:Thalidomide / Q000009:adverse effects*
D013792:Thalidomide