title: [The immunological aspects of primary chronic septic endocarditis in acquired heart defects. The treatment approaches].
abstract: A total of 266 patients with degree I primary chronic septic endocarditis concurrent with acquired heart disease and 101 apparently healthy subjects were examined. The patients were found to have scarce T helper cells and higher levels of T suppressors (quite the reverse in some patients), decreased proliferative responses of T and B cells and normal levels of circulating immune complexes. It was conceived that there was a block in the synthesis of specific antibodies and a decrease in their affinity. It was proposed that cytokine (enzyme) genes (initiators or repressors) should be exposed at intervals as immunomodulating therapy of immune diseases, as well as in some hereditary diseases.
authors.forename: N N
authors.initials: NN
authors.lastname: Vel'tmander
authors.forename: G M
authors.initials: GM
authors.lastname: Bushmanova
authors.forename: A A
authors.initials: AA
authors.lastname: Blok
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001772:Blood Cell Count; D002908:Chronic Disease; D004697:Endocarditis, Bacterial / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
vernacular_title: Immunologicheskie aspekty pervychnogo khronicheskogo septicheskogo éndokardita na fone priobretennykh porokov serdtsa. Podkhody k lecheniiu.