title: Physiological consequences of loss of plasminogen activator gene function in mice.
abstract: Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.
authors.affiliation: Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142.
authors.forename: P
authors.initials: P
authors.lastname: Carmeliet
authors.forename: L
authors.initials: L
authors.lastname: Schoonjans
authors.forename: L
authors.initials: L
authors.lastname: Kieckens
authors.forename: B
authors.initials: B
authors.lastname: Ream
authors.forename: J
authors.initials: J
authors.lastname: Degen
authors.forename: R
authors.initials: R
authors.lastname: Bronson
authors.forename: R
authors.initials: R
authors.lastname: De Vos
authors.forename: J J
authors.initials: JJ
authors.lastname: van den Oord
authors.forename: D
authors.initials: D
authors.lastname: Collen
authors.forename: R C
authors.initials: RC
authors.lastname: Mulligan
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology; D005337:Fibrin / Q000502:physiology; D005342:Fibrinolysis / Q000235:genetics / Q000502:physiology*; D006128:Growth / Q000235:genetics / Q000502:physiology; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D051379:Mice; D016296:Mutagenesis; D010960:Plasminogen Activators / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D013234:Stem Cells; D013927:Thrombosis / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000172:deficiency / Q000235:genetics / Q000502:physiology
chemical_list: D005337:Fibrin; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator