title: Beware the builders: construction noise changes [14C]GABA release and uptake from amygdaloid and hippocampal slices in the rat.
abstract: The effects of exposure to chronic noise and vibration, produced by construction work, on the release and uptake of [3H]5-hydroxytryptamine ([3H]5-HT) and [14C]gamma-aminobutyric acid ([14C]GABA) from rat amygdaloid and hippocampal slices were investigated. Noise-exposure resulted in increased release, with no significant change in uptake, of [14C]GABA from amygdaloid slices. In hippocampal slices, [14C]GABA release was also increased, but the changes in release were dependent upon the marked decrease in uptake of [14C]GABA into these slices. There was an increase in peak K(+)-evoked release of [3H]5-HT from hippocampal slices, but no other changes in [3H]5-HT release or uptake in either region were observed following noise-exposure. These findings may have important practical implications for the research carried out in laboratories exposed to construction noise and vibrations.
authors.affiliation: Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy's Hospital, London, U.K.
authors.forename: C
authors.initials: C
authors.lastname: Fernandes
authors.forename: S E
authors.initials: SE
authors.lastname: File
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002250:Carbon Radioisotopes; D004781:Environmental Exposure; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009622:Noise / Q000009:adverse effects*; D009928:Organ Specificity; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D005680:gamma-Aminobutyric Acid; D011188:Potassium