Glucocorticoid responsive ACTH secreting bronchial carcinoid tumours contain high concentrations of glucocorticoid receptors.
Cushing's syndrome due to a bronchial ACTH secreting carcinoid tumour may be difficult to distinguish from a pituitary microadenoma (corticotrophinoma) causing Cushing's disease, since in both disorders ACTH secretion may be responsive to glucocorticoids. Why some bronchial carcinoid tumours are responsive is unknown but it could be because of co-secretion of corticotrophin releasing factor (CRF) and/or expression of glucocorticoid receptors. We report two patients with glucocorticoid responsive ACTH secreting bronchial carcinoid tumours, neither of whom produced or responded to CRF. Significant glucocorticoid receptor binding capacity (92 and 102 pmol/g protein), compared with control lung tissue, was found in extracts from both tumours. These findings suggest that corticotrophinoma-like responses to glucocorticoids observed in some ACTH secreting bronchial carcinoids result from expression of glucocorticoid receptors and are not necessarily related to the production of CRF.
Florkowski
C M
CM
Department of Endocrinology, Christchurch Hospital, New Zealand.
Wittert
G A
GA
Lewis
J G
JG
Donald
R A
RA
Espiner
E A
EA
D000182:ACTH Syndrome, Ectopic / Q000209:etiology* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001984:Bronchial Neoplasms / Q000150:complications* / Q000378:metabolism; D002276:Carcinoid Tumor / Q000150:complications* / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D003907:Dexamethasone; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D008797:Metyrapone; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000378:metabolism*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D003346:Corticotropin-Releasing Hormone; D008797:Metyrapone