The mechanism of action of gastrin releasing peptide (GRP) in stimulating avian gastric acid secretion.
The mechanisms of action of gastrin and gastrin releasing peptide (GRP) in stimulating gastric acid secretion were examined in the anaesthetized turkey. Gastrin and GRP produced dose-dependent increases in acid secretion that were inhibited by the gastrin/CCK-B antagonist CI988. The antagonist did not affect the acid secretory responses to histamine or carbachol. A GRP antagonist (M216140) inhibited the acid response to GRP, but not gastrin. The results suggest that in birds, GRP stimulates acid secretion by release of gastrin, which acts in turn on classical gastrin/CCK-B receptors in the proventriculus.
Campbell
B J
BJ
Physiological Laboratory, University of Liverpool, UK.
Garner
A
A
Dockray
G J
GJ
Hughes
J
J
Dimaline
R
R
D000704:Analysis of Variance; D000818:Animals; D001839:Bombesin / Q000037:antagonists & inhibitors; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D019886:Gastrin-Releasing Peptide; D005755:Gastrins / Q000378:metabolism* / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D014422:Turkeys
D005755:Gastrins; D007211:Indoles; D009842:Oligopeptides; D010455:Peptides; D011949:Receptors, Cholecystokinin; C061858:ICI 216140; C065599:PD 134308; D008536:Meglumine; D019886:Gastrin-Releasing Peptide; D001839:Bombesin