Secondary solid malignant tumors occurring after bone marrow transplantation for severe aplastic anemia given thoraco-abdominal irradiation.
OBJECTIVE
We have evaluated irradiation doses received at location of secondary solid tumors occurring after bone marrow transplantation (BMT) in five of 147 patients grafted for severe aplastic anaemia.


RESULTS
All 5 tumors occurred within the radiation field penumbra. The estimated received dose varied from 6 Gy for one inner field secondary tumor, to 2.5 Gy for the remaining secondary tumors.


CONCLUSIONS
Tumors may arise in the zone where the delivered radiation dose drops dramatically. Irradiation, with associated cofactors, may promote the development of epidermoid carcinoma in irradiated patients for BMT.
Pierga
J Y
JY
Radiotherapy Department, Institut Gustave Roussy, Villejuif, France.
Socie
G
G
Gluckman
E
E
Devergie
A
A
Henry-Amar
M
M
Bridier
A
A
Girinsky
T
T
Nguyen
J
J
Cosset
J M
JM
D000005:Abdomen / Q000528:radiation effects; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D018277:Carcinoma, Mucoepidermoid / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D006084:Graft Rejection / Q000517:prevention & control; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D015182:Lymphatic Irradiation; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D011829:Radiation Dosage; D011879:Radiotherapy Dosage; D013909:Thorax / Q000528:radiation effects