The effect of cis-DDP and Pt mercaptopyridine complexes on cell lines in vitro.
The effect of Platinum (II) complexes with mercaptopyridines on cell lines (fibroblasts 3T3 and the tumour ones F10, Föhn, Lovo) were studied. Synthesis and characterization of the compounds are reported together with the preliminary in vitro tests. Data obtained on cytopathogenic effect (CPE), cell growth and colony forming ability demonstrated that all the platinum mercaptopyridines tested are more active than cisplatin in the same conditions.
Mazzo
M
M
Dipartimento di Farmacologia, Università di Padova.
Cherchi
V
V
Nicolini
M
M
Sindellari
L
L
Sitran
S
S
Manchiaro
P
P
D'Ancona
S
S
Berti
T
T
D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008546:Melanoma, Experimental / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D009944:Organoplatinum Compounds; D011725:Pyridines; D002945:Cisplatin