Influence of intra-articular sodium hyaluronate and polysulphated glycosaminoglycans on the biochemical composition of equine articular surface repair tissue.
The influence of repeated intra-articular injections of sodium hyaluronate and polysulphated glycosaminoglycan on the repair of full-thickness osteochondral defects was examined in the midcarpal joints of ponies. The study showed no significant difference between treated and control groups with regard to total collagen content, uronic acid content or the relative proportions of Type I and Type II collagen in the repair tissue, indicating that the drugs did not affect the biochemical composition of the repair tissue 11 weeks after defect induction.
Barr
A R
AR
Department of Veterinary Surgery, University of Bristol, Avon, UK.
Duance
V C
VC
Wotton
S F
SF
Waterman
A E
AE
D000818:Animals; D002350:Carpus, Animal / Q000737:chemistry / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D002358:Cartilage, Articular / Q000737:chemistry / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D003094:Collagen / Q000032:analysis; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000494:pharmacology*; D006736:Horses / Q000293:injuries* / Q000502:physiology; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007270:Injections, Intra-Articular / Q000662:veterinary; D010446:Peptide Fragments / Q000032:analysis; D014574:Uronic Acids / Q000032:analysis; D014945:Wound Healing / Q000187:drug effects*
D006025:Glycosaminoglycans; D010446:Peptide Fragments; D014574:Uronic Acids; D006820:Hyaluronic Acid; D003094:Collagen