title: Technetium-99m methoxy isobutyl isonitrile simultaneous evaluation of ventricular function and myocardial perfusion in patients with congenital heart disease.
abstract: The authors evaluated the clinical applications of Tc-99m methoxy isobutyl isonitrile (MIBI) in the simultaneous assessment of ventricular function and myocardial perfusion in patients with congenital heart disease. Global ventricular function was assessed by first-pass ECG gated study. Myocardial perfusion was evaluated on images performed 1 hour after the injection of the tracer. Regional wall motion and systolic thickening were assessed by gated study acquired after the perfusion study. Two young patients were studied after a surgical Glenn procedure. The first patient, with a history of transposition of the great vessels and univentricular heart, had an ejection fraction of 44%. The left ventricle was dilated and the right ventricle was not appreciable. The septal and inferoapical regions showed reduced perfusion and reduced systolic thickening. The second patient, with a history of pulmonary atresia, septal defect and left ventricular hypoplasia, had a right ventricular ejection fraction of 37%. Regional wall motion, systolic thickening, and myocardial perfusion were normal. The right ventricle was hypertrophic and larger than the left ventricle. Thus, a single injection of Tc-99m MIBI allows noninvasive simultaneous assessment of global and regional ventricular function and myocardial perfusion in young patients with complicated congenital heart disease.
authors.affiliation: Medical School, University Feolericolli, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Imbriaco
authors.forename: A
authors.initials: A
authors.lastname: Cuocolo
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: E
authors.initials: E
authors.lastname: Nicolai
authors.forename: A
authors.initials: A
authors.lastname: Nappi
authors.forename: L
authors.initials: L
authors.lastname: Celentano
authors.forename: G
authors.initials: G
authors.lastname: Palma
authors.forename: C
authors.initials: C
authors.lastname: Vosa
mesh_terms: D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D008297:Male; D017256:Technetium Tc 99m Sestamibi; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D017256:Technetium Tc 99m Sestamibi