[Research of antiparasitic agents: 1(nitrophenyl)-3-(methyl-3-indolyl)-prop-2-ene-1-ones (Nitroindolylchalcones)].
The synthesis and the study of the antiparasitic properties of various 1-(nitro-phényl)-3-(méthyl-3-indolyl)-prop-2-ene-1-ones (Nitroindolylchalcones) show interesting antiprotozoal activities on E. histolytica and T. vaginalis. No significative activity appears in vivo with animals on helminthes.
Alaoui
M A
MA
Laboratoire de Chimie thérapeutique, Faculté de Pharmacie de Paris-Sud, Chatenay-Malabry.
Gayral
P
P
Kirkiacharian
S
S
D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects*; D005260:Female; D006926:Hymenolepis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009559:Nippostrongylus / Q000187:drug effects*; D051381:Rats; D014246:Trichomonas vaginalis / Q000187:drug effects*
D002599:Chalcone
Recherche d'agents antiparasitaires: 1-(nitrophényl)-3-(méthyl-3- indolyl)-prop-2-ène-1-ones (Nitroindolylchalcones).