Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris.
We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris. A rebound decrease in exercise tolerance and increase of exercise-induced myocardial ischaemia were registered on the first day of nifedipine withdrawal.
Martsevich
S Y
SY
Department of Preventive Pharmacology, Research Centre for Preventive Medicine of Russia, Moscow.
Koutishenko
N
N
Metelitsa
V I
VI
D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology; D009543:Nifedipine / Q000009:adverse effects*; D010865:Pilot Projects; D013375:Substance Withdrawal Syndrome
D009543:Nifedipine