title: Effect of heparin on hemagglutinin of herpes simplex virus type 1.
abstract: Heparin inhibited the hemagglutinin activity of herpes simplex virus (HSV) type 1. The minimal inhibitory concentration of heparin required to inhibit 8 hemagglutination (HA) U of HSV ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the HA inhibitory factor of heparin. On the other hand, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by HSV. Virus-heparin complex formation was observed by sedimenting heparin with the virus particles.
authors.affiliation: Division of 2nd Microbiology, Hiroshima Prefectural Institute of Public Health and Environment Science, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Noda
authors.forename: Y
authors.initials: Y
authors.lastname: Inaba
authors.forename: M
authors.initials: M
authors.lastname: Seno
authors.forename: Y
authors.initials: Y
authors.lastname: Kanamoto
authors.forename: S
authors.initials: S
authors.lastname: Tokumoto
mesh_terms: D000818:Animals; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006389:Hemagglutinins, Viral / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000276:immunology*; D051379:Mice
chemical_list: D006389:Hemagglutinins, Viral; D006493:Heparin