[EEG changes in type I and type II lissencephaly].
Lissencephaly syndromes are rare disturbances of the neuronal migration with agyria and/or pachygyria. Typical patterns in the EEG of 5 children with lissencephaly are presented. Rhythmic alpha- or beta-waves with high amplitudes of diffuse or fronto-precentral localisation are characteristic in type I lissencephaly. In type II lissencephaly initially theta- or delta-waves of somewhat lower amplitude are observed. Sharp and slow wave-complexes of very high amplitude are found more often in type I lissencephaly. They seem to correlate with the severity of the brain malformation and the epilepsy. In both types of lissencephaly the spatial organisation of the background activity and the sleep-wake differentiation are absent. The EEG of most type I lissencephalies show no reactivity to intravenous benzodiazepines. With increasing age the frequency of the background activity and of the high amplitude rhythmic waves decrease in type I and increase in type II lissencephaly. A complete dedifferentiation of the EEG tracings has been observed in the course of type I lissencephaly. Lissencephaly is diagnosed by imaging techniques. However, with a high probability lissencephaly can be suspected already by its EEG.
Bode
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H
Universitäts-Kinderspital, Basel/Schweiz.
Bubl
R
R
D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002886:Chromosomes, Human, Pair 17; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000145:classification; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male
EEG-Veränderungen bei Typ I und Typ II Lissenzephalien.