Macrophage response to experimental implantation of polypropylene prostheses.
We have assessed the macrophage response to polypropylene mesh (Marlex) implanted into the abdominal wall of New Zealand white rabbits, using RAM-11, a monoclonal antibody specific for rabbit macrophages. The response diminishes during the course of the first 90 days after implantation, although the presence of other cell types typical of foreign-body reactions increases. We have also confirmed the high degree of integration of the biomaterial into the wall achieved after 9 weeks. This has been determined using light and scanning electron microscopy. Likewise, we have observed the formation of numerous adhesions between the polypropylene mesh and the viscera of the abdominal cavity.
Bellón
J M
JM
Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala de Henares, Madrid, Spain.
Bujan
J
J
Contreras
L
L
Hernando
A
A
Jurado
F
F
D000818:Animals; D000911:Antibodies, Monoclonal; D001672:Biocompatible Materials / Q000009:adverse effects; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011095:Polyethylenes / Q000009:adverse effects; D011126:Polypropylenes / Q000009:adverse effects; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D013526:Surgical Mesh / Q000009:adverse effects; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology
D000911:Antibodies, Monoclonal; D001672:Biocompatible Materials; C016674:Plastipore; D011095:Polyethylenes; D011126:Polypropylenes