[Effect of SC1001-sodium on ADA activity of the thymus, spleen and brain in repeated seizure rats].
Twenty nine adult SD rats in the experiment were randomly separated into two groups. Nineteen rats of them were intramuscularly injected (i.m.) with Coriaria lactone (CL, 2.5 mg/kg for female rat; 30 mg/kg for male rat) two days a time, continued 28 times, to induce repeated seizures, as the experimental group. The control group (n = 10) was injected with normal saline (N.S.) in the same volume as that of CL. The rats of experimental group were subdivided into a treatment group (n = 9) with SC1001Na (200 mg/kg) and a placebo group (n = 10) receiving N.S. in the same volume as that of SC1001 Na. All rats of repeated seizure were administered once every day for a week. The results indicated that SC1001Na (200 mg/kg) could inhibit in some degree the growth of immune organs (spleen and thymus) and significantly decrease the ADA activity of thymus, cerebrum and cerebellum, suggesting that the antiepileptic mechanism of SC1001Na is probably related with the decreased activity of ADA and the increased adenosine level in brain.
He
J
J
Chai
H
H
Chen
Q
Q
Li
Y
Y
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D007783:Lactones; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000627:therapeutic use*; D013154:Spleen / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology
D000927:Anticonvulsants; D007783:Lactones; C072444:SC 1001; C049836:coriaria lactone; D012964:Sodium; D000243:Adenosine Deaminase