title: Dental plaque inhibition by a combination of triclosan and polydimethylsiloxane (silicone oil).
abstract: It has previously been shown that a toothpaste which contains triclosan and polydimethylsiloxane (silicone oil) improved gingival health in a test panel with established gingivitis more markedly than usually observed when testing commercial triclosan-containing toothpastes. In the present study the mode of action of combinations of silicone oil and triclosan was investigated. An in vitro experiment showed that triclosan was retained in a thin layer of silicone oil on the inner surfaces of test tubes that had been treated with the combination of triclosan and silicone oil. This triclosan was slowly released and inhibited the growth of bacteria in the test tubes. Silicone oil alone and in combination with triclosan was able to inhibit polysaccharide adhesion to the test tubes in the presence of a strain of Streptococcus sobrinus and a sucrose-containing medium. Corresponding in vivo experiments showed similar results; teeth topically treated with silicone oil and triclosan showed a marked plaque reduction, and those treated with silicone oil alone showed a moderate reduction, as compared with a placebo. The silicone oil plus 0.3% triclosan combination inhibited plaque formation also on proximal surfaces. It appears likely that this combination provides a reservoir of triclosan in the thin layer of silicone oil which binds strongly to teeth because of its low surface tension. Triclosan is then slowly released into saliva because of its low solubility in this fluid.
authors.affiliation: Department of Prosthetic Dentistry and Stomatognatic Physiology, Dental Faculty, University of Oslo, Norway.
authors.forename: J E
authors.initials: JE
authors.lastname: Ellingsen
authors.forename: G
authors.initials: G
authors.lastname: Rölla
mesh_terms: D000328:Adult; D003773:Dental Plaque / Q000517:prevention & control*; D004129:Dimethylpolysiloxanes / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D012828:Silicones / Q000494:pharmacology / Q000627:therapeutic use*; D016986:Streptococcus sobrinus / Q000187:drug effects / Q000254:growth & development; D014260:Triclosan / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004129:Dimethylpolysiloxanes; D012828:Silicones; D014260:Triclosan; C013830:baysilon