title: Two inhibitors of platelet aggregation from a Panus species (Basidiomycetes).
abstract: Two inhibitors of platelet aggregation were isolated from fermentations of Panus sp. 9096. One inhibitor proved to be identical to naematolon (2), an antibiotic previously isolated by S. Backens et al. from several Hypholoma species. The other metabolite, panudial (1), is a new nordrimane (cis-annelation of the bicyclus) lacking the carbon atom in position 10 of the drimane skeleton. Panudial is a potent inhibitor of bovine and human platelet aggregation stimulated by different inducers.
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Lorenzen
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: U
authors.initials: U
authors.lastname: Anders
authors.forename: H
authors.initials: H
authors.lastname: Hindermayr
authors.forename: F
authors.initials: F
authors.lastname: Hansske
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000633:toxicity; D016718:Arachidonic Acid / Q000494:pharmacology; D001487:Basidiomycota / Q000254:growth & development; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D003094:Collagen / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D012310:Ristocetin / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000935:Antifungal Agents; D001643:Bridged Bicyclo Compounds; D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; D013764:Tetrahydronaphthalenes; D012310:Ristocetin; C086704:panudial; D016718:Arachidonic Acid; D013928:Thromboxane A2; D000244:Adenosine Diphosphate; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D003094:Collagen; C086703:naematolon; D013917:Thrombin