Euonymoside A: a new cytotoxic cardenolide glycoside from the bark of Euonymus sieboldianus.
A new cytotoxic cardenolide glycoside, euonymoside A (1), was isolated from the bark of Euonymus sieboldianus. The structure of 1 was elucidated as acovenosigenin A-3-O-beta-D-glucopyranosyl (1-->2)-alpha-L-rhamnopyranoside. The IC50 values of 1 against A549 (human lung carcinoma) and SK-OV-3 (human ovary adenocarcinoma) were 0.06 and 0.4 micrograms/ml, respectively.
Baek
N I
NI
Laboratory of Natural Products, Korea Ginseng and Tobacco Research Institute, Taejeon, Korea.
Lee
Y H
YH
Park
J D
JD
Kim
S I
SI
Ahn
B Z
BZ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004073:Digitoxigenin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; C086295:euonymoside A; D004073:Digitoxigenin