Cefadroxil concentrations in human serum, gingiva, and mandibular bone following a single oral administration.
Cefadroxil concentrations in human serum, gingiva, and mandibular bone were measured by a paper disk method following a single 500-mg oral dose. The mean peak concentrations in serum, gingiva, and mandibular bone occurred at the identical time, 3 hours, and were 12.92 micrograms/mL, 6.50 micrograms/g, and 2.67 micrograms/g, respectively. Mean cefadroxil concentration ratios of gingiva/serum and mandibular bone/serum at the peak time were 0.54 and 0.21, respectively. Mean concentrations in gingiva and mandibular bone at the peak time exceeded the minimum inhibitory concentrations for 90% of clinically isolated strains of a alpha-hemolytic streptococci.
Akimoto
Y
Y
Nihon University School of Dentistry at Matsudo, Japan.
Komiya
M
M
Kaneko
K
K
Fujii
A
A
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000539:Alveolar Process / Q000378:metabolism; D002433:Cefaclor / Q000097:blood / Q000493:pharmacokinetics; D002434:Cefadroxil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002506:Cephalexin / Q000097:blood / Q000493:pharmacokinetics; D002854:Chromatography, Paper; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D008297:Male; D008334:Mandible / Q000378:metabolism*; D008964:Molar, Third / Q000601:surgery*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014081:Tooth Extraction
D002434:Cefadroxil; D002433:Cefaclor; D002506:Cephalexin