Plasma xanthine oxidase level and alcohol administration.
The acute administration of ethanol by gastric catheter significantly increases the plasma xanthine oxidase activity in both rats and hamsters without changing other enzyme activities--alanine aminotransferase and aspartate aminotransferase. The plasma xanthine oxidase level seems to be a sensitive marker of liver damage. Its higher activity due to the acute ethanol intoxication may have an impact on ethanol organ damage.
Zima
T
T
First Department of Medical Chemistry and Biochemistry, School of Medicine I, Charles University, Prague, Czech Republic.
Novák
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L
Stípek
S
S
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D006224:Cricetinae; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D000860:Hypoxia / Q000139:chemically induced; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D014969:Xanthine Oxidase / Q000097:blood* / Q000378:metabolism*
D000431:Ethanol; D014969:Xanthine Oxidase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase