Valproate-associated acute pancreatitis in a child with neuronal ceroid lipofuscinosis.
An 11-year-old girl with juvenile neuronal ceroid lipofuscinosis developed acute pancreatitis secondary to valproic acid treatment, which resolved after discontinuation of the medication and conservative treatment. To my knowledge, this is the first reported case of neuronal ceroid lipofuscinosis with valproate-associated pancreatitis. Children with neuronal ceroid lipofuscinosis may be susceptible to developing this complication.
Talwar
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Section of Pediatric Neurology, University of Arizona Health Sciences Center, Tucson 85724.
D000208:Acute Disease; D002648:Child; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D010195:Pancreatitis / Q000139:chemically induced* / Q000503:physiopathology; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D014635:Valproic Acid / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use*
D014635:Valproic Acid