[Calcium channel blockers as antidepressants--a property of the class or of the individual preparation?].
Only did nifedipine and fendiline decrease immobilization time in mice in the tail suspension test. 5-Hydroxytryptophan-induced head-twitches were slightly (insignificantly) diminished by nifedipine and verapamil. The two drugs potentiated the hypothermic action of reserpine. Fendiline and cinnarizine increased the effect of 5-hydroxytryptophan, but did not modify the effect of reserpine. Diltiazem was virtually inactive in these tests. All the calcium channel blockers decreased the cataleptic action of haloperidol. It is concluded that nifedipine and fendiline are promising in stress-induced reactive depression.
Kozlovskiĭ
V L
VL
Prakh'e
I V
IV
D000275:Adjustment Disorders / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D007035:Hypothermia / Q000139:chemically induced / Q000188:drug therapy; D007103:Immobilization; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D051381:Rats
D000928:Antidepressive Agents; D002121:Calcium Channel Blockers
Blokatory kal'tsievykh kanalov kak antidepressanty--svoĭstvo klassa ili otdel'nogo preparata?