title: Molybdenum but not copper counteracts cysteine-induced tibial dyschondroplasia in broiler chicks.
abstract: Studies were conducted to evaluate the ability of copper and molybdenum to prevent cysteine-induced tibial dyschondroplasia in broiler chicks. Experiment 1 was a 3 x 3 factorial arrangement of treatments used to investigate the interaction between Cu (0, 150 or 300 mg/kg diet) and Mo (0, 10, or 100 mg/kg diet) on cysteine-induced tibial dyschondroplasia. Molybdenum at both supplemental levels, but not Cu, prevented cysteine-induced tibial dyschondroplasia. In Experiment 2 (a 3 x 3 factorial arrangement of treatments with 0, 5 or 10 g/kg diet of cysteine and 0, 10 or 100 mg/kg diet of Mo), Mo prevented cysteine-induced but not spontaneous tibial dyschondroplasia. Cysteine and Mo did not affect the mechanical properties of the tibiotarsus. In Experiment 3, cysteine (0 or 10 g/kg diet) and Mo (0 or 100 mg/kg diet) were used to study the tissue concentrations of mineral and hepatic sulfite oxidase activity. Supplemental Mo increased Mo concentrations in the plasma and liver. Cysteine prevented these increases; however, cysteine, in the absence of supplemental Mo, did not affect concentrations of Mo in these tissues. Dietary cysteine and/or Mo did not affect tissue levels of Cu. We conclude that Mo prevents cysteine-induced tibial dyschondroplasia and that the induction of tibial dyschondroplasia by cysteine is not related to the Mo and Cu deficiency.
authors.affiliation: Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
authors.forename: Y
authors.initials: Y
authors.lastname: Bai
authors.forename: M L
authors.initials: ML
authors.lastname: Sunde
authors.forename: M E
authors.initials: ME
authors.lastname: Cook
mesh_terms: D000818:Animals; D002645:Chickens; D003300:Copper / Q000627:therapeutic use*; D003545:Cysteine; D005260:Female; D008297:Male; D008982:Molybdenum / Q000627:therapeutic use*; D010009:Osteochondrodysplasias / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced / Q000517:prevention & control*; D013977:Tibia
chemical_list: D003300:Copper; D008982:Molybdenum; D003545:Cysteine