title: Antitussive effects of levodropropizine in the dog.
abstract: The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate from which it is derived. The antitussive activity of levodropropizine in the dog was approximately 1/20 of that of codeine phosphate.
authors.affiliation: Department of Pharmacology, Huntingdon Research Centre, UK.
authors.forename: P L
authors.initials: PL
authors.lastname: Munt
authors.forename: G
authors.initials: G
authors.lastname: Clavenna
authors.forename: D R
authors.initials: DR
authors.lastname: Algate
authors.forename: R M
authors.initials: RM
authors.lastname: Leach
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D003061:Codeine / Q000494:pharmacology; D003371:Cough / Q000188:drug therapy; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D008297:Male; D011409:Propylene Glycols / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000996:Antitussive Agents; D011409:Propylene Glycols; C035916:dipropizine; D003061:Codeine