Cesium uptake studies on human erythrocytes.
The uptake of Cs+ ions into the erythrocytes of abstemious volunteers and of alcoholic patients was followed using 133Cs NMR. The uptake rates are approximately linear with a rate of 0.33 mM.h-1 at an extracellular Cs+ concentration of 10 mM. There is no discernible difference in the uptake rate between the two classes of subject despite earlier reports that Cs+ distribution is different and consequently that Cs+ transport might be anomalous in alcoholics. There is no evidence of saturation of the input rate and Cs(+)-loaded cells retain their Cs+ when incubated in a Cs(+)-free buffer, strongly suggesting that there is no transport mechanism for the removal of Cs+ from the erythrocyte. Experiments designed to ascertain which intracellular ion is being replaced by Cs+ indicate that it predominantly displaces K+.
Bramham
J
J
Department of Chemistry, The University, St. Andrews, Scotland.
Riddell
F G
FG
D000437:Alcoholism / Q000097:blood; D002586:Cesium / Q000097:blood* / Q000493:pharmacokinetics; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D017136:Ion Transport; D009682:Magnetic Resonance Spectroscopy; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D002586:Cesium; D012964:Sodium; D011188:Potassium