Effect of rush immunotherapy in house-dust-mite (HDM)-sensitive adult bronchial asthma: changes in in vivo and in vitro responses to HDM.
An open study was conducted to evaluate the changes in in vivo and in vitro responses to house-dust-mite (HDM) after rush immunotherapy (RI). A 7-day RI protocol using an extract containing HDM allergen was administered to 12 subjects with HDM-sensitive asthma, and the effects on bronchial responsiveness and serum antibody levels were evaluated up to 16 or 20 weeks after RI. The levels of HDM-specific IgG, IgG1 and IgG4 antibodies were significantly elevated from 4 or 8 weeks after RI. Provocative doses causing a 20% fall in FEV1 (PD20) by allergen inhalation were elevated in all subjects at 16 to 20 weeks after RI. There was a high correlation between the increase in log-PD20 and the increase in the ratio of HDM-specific IgG4 to IgG1 (r = 0.68, p < 0.05). The results suggest that RI elicits the improvement of allergen-specific bronchial responsiveness and the increase in serum antibody levels within a relatively short period.
Nagata
M
M
Second Department of Internal Medicine, Saitama Medical School.
Yamamoto
H
H
Tabe
K
K
Kimura
I
I
Houya
I
I
Kuramitsu
K
K
Kiuchi
H
H
Yanagihara
Y
Y
Sakamoto
Y
Y
Yamamoto
K
K
D000293:Adolescent; D000328:Adult; D000485:Allergens; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D001985:Bronchial Provocation Tests; D004391:Dust / Q000009:adverse effects; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007167:Immunotherapy / Q000379:methods*; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D013997:Time Factors
D000485:Allergens; D004391:Dust; D007074:Immunoglobulin G; D007073:Immunoglobulin E