Predictors of response to alprazolam and placebo in patients with panic disorder.
Date from a panic disorder treatment study with 506 patients, comparing alprazolam and placebo in a double-blind manner for 8 weeks, were analyzed to identify demographic and clinical characteristics of the patients that might predict response to treatment. The strongest predictors of response to alprazolam were age over 40, and lower baseline levels of anxiety and phobic symptoms. Predictors of response to placebo were weaker and, in addition to lower levels anxiety and panic attacks, included a lack of previous psychiatric treatment.
Woodman
C L
CL
University of Iowa, Department of Psychiatry, Iowa City 52242.
Noyes
R
R
Ballenger
J C
JC
Lydiard
R B
RB
Sievers
G
G
Mihalko
D
D
D000328:Adult; D000525:Alprazolam / Q000009:adverse effects / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000188:drug therapy* / Q000523:psychology; D010555:Personality Inventory; D012917:Social Adjustment
D000525:Alprazolam