title: Increased polymorphonuclear leukocyte Fc gamma-dependent chemiluminescence in active psoriasis is not related to FcRIII (CD16) receptor expression.
abstract: The role of the two main serum opsonins (IgG and C3b) in the induction of polymorphonuclear leukocyte chemiluminescence was studied in a group of psoriatic patients. Chemiluminescence was stimulated with zymosan opsonized by fresh plasma (IgG- and C3b-dependent chemiluminescence) or by complement-depleted plasma (IgG-dependent chemiluminescence). While C3b-dependent chemiluminescence was similar in patients with chronic or active forms of psoriasis, IgG-dependent chemiluminescence was significantly increased in patients with active disease. However, FcR-III expression, evaluated by means of flow cytofluorimetry, was similar in the different groups of patients studied. The discrepancy between Fc-receptor (CD16) expression and IgG-dependent chemiluminescence is, therefore, indicative of modifications that occur in psoriatic neutrophils that do not involve FcIII-receptor expression.
authors.affiliation: Department of Dermatology, School of Specialization in Dermatology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: C
authors.initials: C
authors.lastname: Guerriero
authors.forename: A
authors.initials: A
authors.lastname: Venier
authors.forename: C
authors.initials: C
authors.lastname: Rumi
authors.forename: S
authors.initials: S
authors.lastname: Bussa
authors.forename: R
authors.initials: R
authors.lastname: Fresu
authors.forename: P
authors.initials: P
authors.lastname: De Sole
mesh_terms: D000328:Adult; D000368:Aged; D003179:Complement C3b / Q000378:metabolism; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D009895:Opsonin Proteins / Q000378:metabolism; D011565:Psoriasis / Q000276:immunology* / Q000378:metabolism; D017463:Receptors, Complement 3b / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism*; D016897:Respiratory Burst; D015054:Zymosan / Q000494:pharmacology
chemical_list: D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D017463:Receptors, Complement 3b; D017452:Receptors, IgG; D003179:Complement C3b; D015054:Zymosan