title: Effect of lung transplantation on right and left ventricular volumes and function measured by magnetic resonance imaging.
abstract: To evaluate the effect of lung transplantation on right ventricular (RV) and left ventricular (LV) volumes and function, magnetic resonance imaging (MRI) was performed in 11 patients before and 6 to 24 months after single (n = 7) or double (n = 4) lung transplantation as well as in 15 healthy control subjects. Prior to transplantation, RV end-diastolic (RVEDVI, ml/m2) and end-systolic (RVESVI, ml/m2) volume indices were significantly increased in patients compared with those in control subjects. RV ejection fraction (RVEF, %), although within the lower normal range, was significantly reduced. In contrast, LV volume indices (ml/m2) were significantly smaller in patients than in control subjects, whereas LV ejection fraction (LVEF, %) was not different from that in normal subjects. After lung transplantation, MRI revealed a significant reduction in RVEDVI from 73 +/- 29 to 54 +/- 14 (p = 0.03) and RVESVI from 38 +/- 23 to 20 +/- 6 (p = 0.01) with a concomitant significant increase in RVEF from 48 +/- 14 to 63 +/- 6 (p = 0.01). Consecutively, the LV expanded to normal (LVEDVI from 49 +/- 12 to 65 +/- 14, p = 0.01; LVESVI from 23 +/- 9 to 28 +/- 7, p = 0.05), whereas LVEF remained unchanged (55 +/- 9 versus 56 +/- 8).
authors.affiliation: Second Department of Internal Medicine, University of Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Globits
authors.forename: O C
authors.initials: OC
authors.lastname: Burghuber
authors.forename: J
authors.initials: J
authors.lastname: Koller
authors.forename: P
authors.initials: P
authors.lastname: Schenk
authors.forename: H
authors.initials: H
authors.lastname: Frank
authors.forename: M
authors.initials: M
authors.lastname: Grimm
authors.forename: A
authors.initials: A
authors.lastname: End
authors.forename: D
authors.initials: D
authors.lastname: Glogar
authors.forename: H
authors.initials: H
authors.lastname: Imhof
authors.forename: W
authors.initials: W
authors.lastname: Klepetko
mesh_terms: D000328:Adult; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D016014:Linear Models; D008171:Lung Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D016040:Lung Transplantation / Q000502:physiology* / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right