Triacylglycerol in biomembranes.
A better knowledge of the biochemical and biophysical properties of cell membranes has revealed fundamental concepts concerning the regulation of cell functions by intrinsic components of the lipid matrix. Membrane lipids exhibit high chemical heterogeneity, with hundreds of distinct chemical species; studies of structure-function relationships have unraveled new roles for an increasing number of these lipids as determinants of membrane structure, anchors for membrane-associated proteins or signalling agents. Recent observations have confirmed triacylglycerol (TG) as a quantitatively minor intrinsic membrane component which seems to play a specific role in important metabolic events such as cell stimulation or transformation and metastatic processes. The rapid turnover of the acyl chains into TG of cell membranes suggests an active metabolism. In the plasma membrane, TG appears to be implicated in the generation of transient non-bilayer domains suspected to be associated with specific cellular events. This paper summarizes the current information on TG metabolism and focuses on the potential role of this neutral lipid species on the structure and function of cell membranes.
Lerique
B
B
INSERM U.260, Faculté de Médecine Timone, Marseille, France.
Lepetit-Thévenin
J
J
Vérine
A
A
Delpéro
C
C
Boyer
J
J
D000818:Animals; D006801:Humans; D008566:Membranes / Q000502:physiology; D014280:Triglycerides / Q000502:physiology*
D014280:Triglycerides