A method for in vivo high resolution MRI of rat spinal cord injury.
We have developed an implanted radiofrequency coil to obtain high resolution in vivo MR images at 1.9 Tesla of rat spinal cords that have been injured using a standardized weight drop technique. The signal-to-noise ratio and motion artifact suppression of these images is superior to that achieved in earlier attempts at this field strength using an external surface coil. The high quality and spatial resolution provided by this technique afford the possibility for longitudinal studies of experimental spinal cord injury before and after treatment, as well as detailed correlation of in vivo MRI contrast, histopathological findings, and functional deficit, in a controlled setting.
Ford
J C
JC
Department of Radiology, Univeristy of Pennsylvania Medical Center, Philadelphia.
Hackney
D B
DB
Joseph
P M
PM
Phelan
M
M
Alsop
D C
DC
Tabor
S L
SL
Hand
C M
CM
Markowitz
R S
RS
Black
P
P
D000818:Animals; D003288:Contusions / Q000175:diagnosis / Q000473:pathology; D004487:Edema / Q000175:diagnosis / Q000473:pathology; D004867:Equipment Design; D006470:Hemorrhage / Q000175:diagnosis / Q000473:pathology; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000175:diagnosis* / Q000473:pathology; D013499:Surface Properties