Fine needle aspiration diagnosis of angiomyolipoma of the liver using a cell block with immunohistochemical study. A case report.
Fine needle aspiration diagnosis of hepatic angiomyolipoma has been reported rarely. Below we report one such case diagnosed by examination of a cell block. The presence of epithelioid smooth muscle cells, mature adipocytes, thick-walled vessels and extramedullary hematopoiesis established the diagnosis. It was further substantiated by positive staining of the epithelioid cells for muscle-specific actin (HHF-35). The epithelioid cells were also immunoreactive with a melanocytic marker, HMB-45, but not with desmin, vimentin, cytokeratin or S-100 protein. HMB-45 might prove to be a sensitive marker for the epithelioid smooth muscle component of the tumor. The advantage of the routine use of a cell block in fine needle aspiration is emphasized.
Ma
T K
TK
Institutes of Pathology, Queen Elizabeth Hospital, Hong Kong.
Tse
M K
MK
Tsui
W M
WM
Yuen
K T
KT
D000199:Actins / Q000032:analysis; D000328:Adult; D018207:Angiomyolipoma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology*; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology*
D000199:Actins