Preparation of new Schiff bases derived from beta-enaminonitriles and hetarylcarboxaldehydes. Anti-inflammatory and ulcerogenic activities.
Schiff bases 3a-j were prepared by reacting the beta-enaminonitriles (1a,b) with the appropriate hetarylcarboxaldehyde, in boiling ethanol. Structural elucidations for the new compounds (3a-j) were based upon compatible analytical and spectroscopic results. Compounds 1a, 1b, 3a, 3c, 3d and 3i were tested for their anti-inflammatory and ulcerogenic activities.
Atta
S M
SM
Department of the Chemistry of Natural Products, National Research Centre, Dokki-Cairo, Egypt.
Ameen
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005663:Furans; D009570:Nitriles; D012545:Schiff Bases; D002351:Carrageenan