title: p53 protein expression in squamocellular carcinomas of the lip.
abstract: Twenty-six cases of squamocellular carcinomas of the lip were immunostained for p53 protein. Nuclear accumulation of p53 protein was observed in 88% of the 26 carcinomas, in 64% of adjacent "normal" epithelium and in all four cases with adjacent atypical squamous epithelium. 93% of the specimens (13/14) with p53 protein accumulation in "normal" epithelium demonstrated evidence of solar elastosis. UV radiation may induce p53 gene mutation as an early event in the neoplastic transformation.
authors.affiliation: Department of Pathology, Norwegian Radium Hospital, Montebello, Oslo.
authors.forename: A
authors.initials: A
authors.lastname: Berner
authors.forename: R
authors.initials: R
authors.lastname: Holm
authors.forename: A
authors.initials: A
authors.lastname: Naess
authors.forename: O
authors.initials: O
authors.lastname: Hjortdal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D002467:Cell Nucleus / Q000737:chemistry; D006801:Humans; D008048:Lip Neoplasms / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D016159:Tumor Suppressor Protein p53