Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes.
The effect of mycophenolic acid (MPA) on the growth of Epstein-Barr virus (EBV)-transformed B cells and on EBV lytic-cycle gene expression was investigated. MPA inhibited the proliferation of newly infected or established EBV-transformed B-cell lines but was not able to block cell growth transformation or the viral lytic cycle. These results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders.
Alfieri
C
C
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Allison
A C
AC
Kieff
E
E
D001402:B-Lymphocytes / Q000382:microbiology*; D002455:Cell Division / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D006566:Herpesviridae Infections / Q000382:microbiology*; D004854:Herpesvirus 4, Human; D006801:Humans; D008856:Microscopy, Fluorescence; D009173:Mycophenolic Acid / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis
D014764:Viral Proteins; D009173:Mycophenolic Acid