Recent studies on the metabolic activation of chemical carcinogens.
Xenobiotics continue to be found that are metabolized in mammals to electrophilic reactants that form covalently bound adducts to cellular DNA leading to tumor formation. This discussion will be limited to the following two topics: sulfonation in chemical carcinogenesis and endogenous etheno adducts in DNA.
Miller
J A
JA
McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism*
D002273:Carcinogens; D015262:Xenobiotics; D004247:DNA