title: An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study.
abstract: The plasticizer di-2-(ethylhexyl) adipate (DEHA), which may be present in food-contact films, can migrate into certain foodstuffs. Results from plasticizer migration studies into food have enabled an indirect estimate of the maximum daily dietary intake of DEHA. A previous study of the metabolism and pharmacokinetics of DEHA in humans identified the urinary metabolite 2-ethylhexanoic acid (EHA) as a useful marker metabolite for assessing DEHA intake. The present study was designed to investigate urinary EHA concentrations following a controlled dose of DEHA presented with food, and to assess the average daily intake of DEHA in a limited population survey. The urinary elimination profile of EHA, following a dose of DEHA in food, showed that in order to extrapolate DEHA intake from EHA measurements, a 24-hr urine sample was required. In the survey the elimination of EHA was determined in 24-hr urine samples in 112 individuals from five different geographical locations in the UK. No restrictions were placed on age or gender. Estimates of daily intake of DEHA show a skewed distribution with a median value of 2.7 mg. This is similar to an estimated maximum daily intake of 8.2 mg/day, derived using an indirect method by the UK Ministry of Agriculture, Fisheries and Food.
authors.affiliation: Zeneca Central Toxicology, Investigative Toxicology Section, Macclesfield, Cheshire, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Loftus
authors.forename: B H
authors.initials: BH
authors.lastname: Woollen
authors.forename: G T
authors.initials: GT
authors.lastname: Steel
authors.forename: M F
authors.initials: MF
authors.lastname: Wilks
authors.forename: L
authors.initials: L
authors.lastname: Castle
mesh_terms: D000272:Adipates / Q000008:administration & dosage* / Q000652:urine; D000293:Adolescent; D000328:Adult; D002208:Caproates / Q000652:urine*; D004032:Diet; D005260:Female; D005506:Food Contamination; D006801:Humans; D008297:Male; D006113:United Kingdom
chemical_list: D000272:Adipates; D002208:Caproates; C040668:2-ethylhexanoic acid; C013966:dioctyl adipate