Peripheral blood stem cells in children with solid tumors. Part II. Immunocytologic detection of tumor cells in bone marrow and peripheral blood stem cell harvests.
Simultaneous comparative assessment of tumor contamination in bone marrow aspirates and peripheral blood stem cell collections using immunocytochemical techniques was done in 6 children with neuroectodermal tumors. In 3 neuroblastoma patients tumor cells were detected in 5 of 16 marrow samples but not in peripheral blood stem cells. Clonogenic tumor cell reinfusion in the autologous support setting may be avoided in neuroblastoma patients by using peripheral blood stem cells.
Dominici
C
C
Department of Pediatrics, University La Sapienza, Rome, Italy.
Deb
G
G
Angioni
A
A
Landolfo
A
A
Parisi
F
F
Helson
L
L
Donfrancesco
A
A
D000293:Adolescent; D001800:Blood Specimen Collection; D001853:Bone Marrow / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000097:blood / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D008527:Medulloblastoma / Q000097:blood / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009447:Neuroblastoma / Q000097:blood / Q000473:pathology*