Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis.
Interactions between clarithromycin and biofilms formed by Staphylococcus epidermidis were investigated by using a clarithromycin-resistant strain. Treatment of the colonization with a relatively low concentration of clarithromycin resulted in the eradication of slime-like structure and a decrease in the quantity of hexose. Another result was increased penetration of antibiotics through the biofilm of S. epidermidis.
Yasuda
H
H
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Ajiki
Y
Y
Koga
T
T
Yokota
T
T
D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005898:Glass; D006601:Hexoses / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D013055:Spectrophotometry, Infrared; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D006601:Hexoses; D017291:Clarithromycin