Serum manganese superoxide dismutase (MnSOD) and histological virulence of ovarian cancer.
The serum level of a scavenging enzyme, manganese superoxide dismutase (MnSOD), was examined in 78 patients with ovarian cancer. Tumors included 27 stage I, 6 stage II, 37 stage III and 8 stage IV diseases. They were classified as 43 serous, 18 mucinous, 10 clear cell and 7 endometrioid neoplasms, and grouped into 25 grade I, 27 grade II and 26 grade III cancers. Factors affecting the MnSOD level were estimated by analysis of variance and Bonferroni t-test. From these, both the stage and histology were less-effectively affected by the level, while the histological grade was estimated as effective with p < 0.05. The MnSOD value increased significantly in accordance with the escalation of the tumor grade with p = 0.02 for grade I vs II, 0.005 for II vs III, and 0.0001 for I vs III respectively. MnSOD determination may be unique as a predictor of the histological virulence of ovarian carcinoma.
Nishida
T
T
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan.
Sugiyama
T
T
Kataoka
A
A
Tashiro
M
M
Yakushiji
M
M
Ishikawa
M
M
D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology*; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase