Protective effect of hachimi-jio-gan, an oriental herbal medicinal mixture, against cerebral anoxia.
The protective effect of Hachimi-jio-gan (HJ) against cerebral anoxia was investigated with various experimental models in mice. Minimal effective dose of HJ which significantly prolonged the survival time was 0.5 g/kg, p.o. for normobaric hypoxia and 0.5 g/kg, p.o. for KCN- (4 mg/kg, i.v.) induced anoxia. HJ reduced the duration of coma induced by a sublethal dose of KCN (1.8 mg/kg, i.v.) in a dose-dependent manner. Furthermore HJ potentiated the anti-anoxic effect of physostigmine and the effect of HJ was diminished by the treatment with atropine.
Hirokawa
S
S
Department of Pharmacognosy, Faculty of Pharmaceutical Science, Nagoya City University, Japan.
Nose
M
M
Amagaya
S
S
Oyama
T
T
Ogihara
Y
Y
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010830:Physostigmine / Q000494:pharmacology; D011190:Potassium Cyanide
D004365:Drugs, Chinese Herbal; C054591:hachimijiogan; D001285:Atropine; D010830:Physostigmine; D011190:Potassium Cyanide