Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone.
A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3 beta-ol dehydrogenase, 21-hydroxylase, and 11 beta-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.
Katz
E
E
Division of Reproductive Endocrinology, University of Maryland, Baltimore.
Scherzer
W J
WJ
Mansfield
R J
RJ
Adashi
E Y
EY
D000311:Adrenal Glands / Q000187:drug effects* / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D009154:Mutation; D010052:Ovariectomy; D013255:Steroid 21-Hydroxylase / Q000235:genetics; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D013255:Steroid 21-Hydroxylase