title: Endocrinological, ultrasonographic and clinical findings in adolescent and adult polycystic ovary patients: a comparative study.
abstract: This study was performed to compare clinical and endocrine features and ultrasonographic data of adolescent (< or = 18 years old) and adult (> or = 19 years old) patients with ultrasound-diagnosed polycystic ovaries (PCOs) in our Reproductive Endocrinology outpatient clinic. The adolescent group included 35 PCO patients while 125 were in the adult group. Hirsutism was present in 64.7% of the adolescent group and in 49.6% of the adult group. Menstrual irregularities were detected as oligomenorrhea (42.8%), amenorrhea (20%) and irregular but normal cycles (17.4%) in the adolescent group; the figures for the adult group were 46.4, 8.8 and 23.2%, respectively. These differences were not statistically significant. The mean body mass index of the adult PCO group was significantly higher than the adolescent PCO group (p < 0.05). The endocrine features (estradiol, follicle stimulating hormone, luteinizing hormone (LH), prolactin, total testosterone, free testosterone, 17-OH progesterone, androstenedione, thyroid stimulating hormone, dehydroepiandrosterone sulfate (DHEAS)) and the ovarian volume of both groups were comparable. There was a significant positive correlation between ovarian volume and serum LH, total testosterone, free testosterone, androstenedione and DHEAS in both groups. We conclude that polycystic ovarian syndrome is a disorder with perimenarchal onset, the clinical, endocrine and ultrasound features of which will not change by age, although patients are prone to gain weight as they get older.
authors.affiliation: Department of Reproductive Endocrinology and Infertility, Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Gülekli
authors.forename: N O
authors.initials: NO
authors.lastname: Turhan
authors.forename: S
authors.initials: S
authors.lastname: Senöz
authors.forename: S
authors.initials: S
authors.lastname: Kükner
authors.forename: H
authors.initials: H
authors.lastname: Oral
authors.forename: O
authors.initials: O
authors.lastname: Gökmen
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D000735:Androstenedione / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D009839:Oligomenorrhea / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D006908:Hydroxyprogesterones; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone; D011388:Prolactin; D005640:Follicle Stimulating Hormone