title: [The effect of butylhydroxyanisole, an antioxidant, on oxidative phosphorylation of myocardial mitochondria in experimental ischemia].
abstract: The present paper evaluated the effect of the antioxidatively acting agent butylhydroxyanisole (BHA) on the oxidative and energetic processes in the mitochondria of the myocardium, both normal and damaged with isoprenaline. BHA was administered for 20 days in a daily dose of 10 mg.kg-1. Experimental necrosis of the myocardium was induced by a single-dose administration of a dose of 25 mg.kg-1 s.c. The results shown in Graphs 1-7 indicate that BHA in the above-mentioned concentration did not act protectively on the metabolic processes taking place in the mitochondria during experimentally induced necroses of the myocardium.
authors.affiliation: Katedra farmakologie a toxikologie Farmaceutické fakulty Univerzity Komenského, Bratislava, SR.
authors.forename: B
authors.initials: B
authors.lastname: Kovácsová
authors.forename: E
authors.initials: E
authors.lastname: Pazin-Hricková
authors.forename: L
authors.initials: L
authors.lastname: Csabáková
authors.forename: P
authors.initials: P
authors.lastname: Svec
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002083:Butylated Hydroxyanisole
vernacular_title: Vliv antioxidacní látky butylhydroxyanizolu na oxidacní fosforylaci mitochondrií myokardu pri experimentálnĕ vyvolané ischemii.