An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions.
To elucidate the anatomical features which predispose artery over vein (AV) crossings to be the preferential sites for retinal branch vein occlusions (RBVO), 11 AV and six vein over artery (VA) crossings in 12 eyes from non-hypertensive donors who were aged 35 to 82 years, were studied by light and electron microscopy. At AV crossings the veins were often observed to abruptly alter direction to pass under the artery. Here focal stratification of the vein basement membrane opposite the point of contact with the artery was seen. A focal reduction in the vein lumen occurred at three of 11 AV crossings. In contrast, deviation of the vein, focal basement membrane stratification or focal narrowing was not seen at VA crossings. Both types of crossings had a common adventitial sheath when each vessel was of large calibre. This study demonstrated anatomical features which predispose AV crossings to be the preferential site for venous occlusion.
Jefferies
P
P
Christchurch Hospital, New Zealand.
Clemett
R
R
Day
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012161:Retinal Artery / Q000033:anatomy & histology* / Q000502:physiology; D012169:Retinal Vein / Q000033:anatomy & histology* / Q000502:physiology; D012170:Retinal Vein Occlusion / Q000209:etiology* / Q000503:physiopathology