title: Duration of spinal anaesthesia is determined by the partition coefficient of local anaesthetic.
abstract: We have compared the duration of motor block produced by four local anaesthetics administered into a chronically implanted subarachnoid catheter in rabbits. Each group (n = 6) received four different doses of amethocaine, bupivacaine, lignocaine or procaine, and the duration of the resulting motor block was assessed. Dose-response curves were plotted for each drug. As a measure of activity of the anaesthetics, we used the dose of each drug required to produce block of 60-min duration (D60 min) and the correlation between D60 min and different drug properties was examined. An inverse linear correlation (r = 0.995; P < 0.01) was observed between log D60 min and the log of the partition coefficient of the local anaesthetics. No correlation was found between the effect and degree of protein binding, pKa or molecular weight. These results suggest that, in spinal anaesthesia, the partition coefficient could be used as a predictor of the duration of anaesthetic action.
authors.affiliation: Department of Anaesthesiology, Rebecca Sieff Government Hospital, Safed, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Langerman
authors.forename: E
authors.initials: E
authors.lastname: Golomb
authors.forename: G J
authors.initials: GJ
authors.lastname: Grant
authors.forename: S
authors.initials: S
authors.lastname: Benita
mesh_terms: D000775:Anesthesia, Spinal; D000779:Anesthetics, Local; D000818:Animals; D002045:Bupivacaine; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D011343:Procaine; D011817:Rabbits; D012995:Solubility; D013748:Tetracaine; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D013748:Tetracaine; D011343:Procaine; D008012:Lidocaine; D002045:Bupivacaine