title: Pre-clinical and clinical studies on Hirulog: a potent and specific direct thrombin inhibitor.
authors.affiliation: Thrombosis and Hemostasis Research Group Biogen, Inc., Cambridge, MA 02142.
authors.forename: J M
authors.initials: JM
authors.lastname: Maraganore
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D024764:Hirudin Therapy; D006629:Hirudins / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; D013917:Thrombin; C074619:bivalirudin