Epidemiological studies in monitoring reproductive effects.
The possible hazards of occupational exposure on the reproductive health of workers is of great interest. In this review, epidemiological study designs suitable for reproductive studies and sources of outcome and exposure data are described with a few examples. Studies have been conducted on hormonal changes, semen quality, fertility, and various outcomes of pregnancy, e.g., spontaneous abortion, congenital malformations, perinatal mortality, birth weight, and health and development of the children. Also, sex distribution of children has been investigated as a possible risk indicator in some recent studies. In epidemiological studies, retrospective or prospective cohort design, case referent and nested case referent designs have been used. The validity of epidemiological studies depend on reliable data on the health effect and the exposure. The registers on congenital malformations and on births and other outcomes of pregnancy are useful sources of data for epidemiological studies. The coverage of the register and the accuracy of its contents should be known if the register is used for research. Personal interview of the worker is an important source of information, although recall problems may weaken the quality of the data. The reliability of the answers may be increased by using a few complementary questions on possible medical confirmation of the event. If both the interview and register data are available, the reliability of the information increases, the same concerns exposure information also. Examples of some conducted studies are given.
Taskinen
H K
HK
Institute of Occupational Health, Helsinki, Finland.
D016208:Databases, Factual; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D016272:Occupational Health; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*