Influence of various compounds on the degradation of hyaluronic acid by a myeloperoxidase system.
Myeloperoxidase in the presence of 0.7 mM hydrogen peroxide degrades hyaluronic by a mechanism which involves iron. Degradation is enhanced in the presence of chloride ion, which is attributed to the formation of hypochlorous acid. Myeloperoxidase-dependent degradation of hyaluronic acid is inhibited by superoxide dismutase, desferrioxamine, iodide ion, bromide ion, mannitol, histidine and various antiinflammatory agents. The destructing agent is presumably the hydroxyl radical.
Lindvall
S
S
Preclinical R & D, Astra Arcus AB, Söderälje, Sweden.
Rydell
G
G
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D012965:Sodium Chloride / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D017665:Hydroxyl Radical; D012965:Sodium Chloride; D006820:Hyaluronic Acid; D006861:Hydrogen Peroxide; D007501:Iron; D009195:Peroxidase