[Effects of the inhibition by catecholaminergic and opiatergic pathways of the electroencephalographic and vegetative pattern induced by corticotropin-releasing factor (CRF) in the rabbit].
The effects of catecholaminergic and opiatergic transmission inhibitors on CRF induced neurophysiological and autonomic patterns were tested. No interactions resulted between naloxone and CRF. Both DDC and MPT significantly reduced electrocortical and vegetative actions of CRF. Only the bradycardia was unmodified after premedications. Therefore our data confirmed the interactions between CRF and catecholaminergic pathways. The bradycardic effect seemed independent from the "stress-like" syndrome induced by CRF.
Marchioni
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E
Istituto Neurologico C. Mondino, Università di Pavia.
Maurelli
M
M
Tartara
A
A
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001919:Bradycardia / Q000139:chemically induced; D002395:Catecholamines / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology* / Q000633:toxicity; D004050:Ditiocarb / Q000494:pharmacology*; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects*; D004723:Endorphins / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D008781:Methyltyrosines / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D013312:Stress, Physiological / Q000139:chemically induced; D019805:alpha-Methyltyrosine
D002395:Catecholamines; D004723:Endorphins; D008781:Methyltyrosines; D009270:Naloxone; D019805:alpha-Methyltyrosine; D003346:Corticotropin-Releasing Hormone; D004050:Ditiocarb
Effetti dell'inibizione della via catecolaminergica e opiatergica sul pattern elettroencefalografico e vegetativo indotto dal corticotropin releasing factor (CRF) nel coniglio.