Activation of potassium channels by diazoxide and cromakalim in insulin-secreting cells is dependent upon internal ADP and channel run-down.
Jaggar
J H
JH
Department of Biomedical Science, The University, Western Bank, Sheffield.
Harding
E A
EA
Ayton
B A
BA
Dunne
M J
MJ
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002460:Cell Line; D019806:Cromakalim; D003981:Diazoxide / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007340:Insulinoma; D007515:Islets of Langerhans / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D010190:Pancreatic Neoplasms; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011758:Pyrroles / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D001578:Benzopyrans; D007328:Insulin; D015221:Potassium Channels; D011758:Pyrroles; D019806:Cromakalim; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003981:Diazoxide