Platelet monoamine oxidase activity in neuroleptic-naive schizophrenic patients: lack of influence of chronic perphenazine treatment.
We investigated the possible relationship between schizophrenia, neuroleptic treatment, and platelet monoamine oxidase (MAO) activity. Platelet MAO activity was similar in neuroleptic-naive schizophrenic patients and healthy controls and was not affected by chronic (10-week) perphenazine treatment. A relationship between platelet MAO activity and central disturbances in schizophrenia remains uncertain.
Spivak
B
B
Gehah Psychiatric Hospital, Petah Tiqva, Israel.
Kosower
N
N
Zipser
Y
Y
Shreiber-Schul
N
N
Apter
A
A
Tyano
S
S
Weizman
A
A
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D010546:Perphenazine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy
D008995:Monoamine Oxidase; D010546:Perphenazine