SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins.
Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.
Jankowski
S A
SA
Department of Human Genetics, University of Michigan, Ann Arbor 48109-0668.
Mitchell
D S
DS
Smith
S H
SH
Trent
J M
JM
Meltzer
P S
PS
D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002478:Cells, Cultured; D002881:Chromosomes, Human, Pair 12; D016384:Consensus Sequence; D005784:Gene Amplification; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D015183:Restriction Mapping; D012509:Sarcoma / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D059470:Tetraspanins
C000715470:MAS1 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; C086385:TSPAN31 protein, human; D059470:Tetraspanins