[Effect of propranolol on circadian rhythm of Goldblatt hypertension in goat].
With the Goldblatt two-kidney two-clip method, persistent hypertension was reproduced in 7 goats. After hypertension was established and stabilized, a beta-receptor inhibitor Propranolol was given to the goats in the usual form of drug administration (20 mg, q 8 h) or in the form of chronotherapy (30 mg, QN). The mean value of BP was computed. The result suggested that, compared with the usual form of therapy, chronotherapy could reduce the hypertension to the same degree, but with less time and less amount of drug.
Xiao
J
J
Wang
D
D
Qiu
H
H
Luo
H
H
Chen
H
H
Xue
Z
Z
D000818:Animals; D002940:Circadian Rhythm; D006041:Goats; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011433:Propranolol / Q000008:administration & dosage*
D011433:Propranolol