title: Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhaha.
abstract: OBJECTIVE
  To determine the efficacy of antibiotics for prophylaxis of recurrent otitis media and treatment of otitis media with effusion (OME) in children.
  
  
  METHODS
  MEDLINE from 1966 through April 1993, textbooks, Current Contents, and bibliographies of selected articles.
  
  
  METHODS
  Thirty-three studies initially identified were reviewed by three blinded reviewers assessing study quality and suitability for inclusion. Twenty-seven met inclusion criteria for the meta-analyses.
  
  
  METHODS
  We abstracted quantitative data and calculated rate differences (RDs) using tympanometry as the preferred outcome measure.
  
  
  RESULTS
  Nine studies of antibiotic prophylaxis of recurrent otitis media with 958 subjects had an RD of 0.11 (95% confidence interval [Cl], 0.03 to 0.19) favoring antibiotic treatment. Twelve studies of short-term patient outcomes of OME with 1697 subjects had an RD favoring antibiotics of 0.16 (95% Cl, 0.03 to 0.29), while eight studies using the ear as the outcome measure with 2052 ears studied had an RD of 0.25 (95% Cl, 0.10 to 0.40). No significant difference was shown between placebo and antibiotics (RD, 0.06; 95% Cl, -0.03 to 0.14) in the eight studies of longer-term outcome of OME. Subgroup analyses by antibiotic grouping, duration of treatment, and duration of disease did not show significant differences.
  
  
  CONCLUSIONS
  Antibiotics appear to have beneficial but limited effect on recurrent otitis media and short-term resolution of OME. Longer-term benefit for OME has not been shown. The findings are limited by the failure of most studies to consider potential confounders and by inability to identify groups of patients most likely to benefit.
authors.affiliation: MetroHealth Clement Center, Cleveland, OH.
authors.forename: R L
authors.initials: RL
authors.lastname: Williams
authors.forename: T C
authors.initials: TC
authors.lastname: Chalmers
authors.forename: K C
authors.initials: KC
authors.lastname: Stange
authors.forename: F T
authors.initials: FT
authors.lastname: Chalmers
authors.forename: S J
authors.initials: SJ
authors.lastname: Bowlin
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D010033:Otitis Media / Q000188:drug therapy / Q000517:prevention & control*; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000517:prevention & control; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents