title: [The effect of the long-term use of a diet enriched with omega-3 polyunsaturated fatty acids on the fatty acid composition, fibrinolytic system indices and lipid spectrum of the blood in patients with ischemic heart disease].
abstract: Fatty fish was included for 7 months into diet of 11 male patients with early stages of ischemic heart disease. Effects of this diet modification on serum fatty acids, lipids and some variables of hemostasis were studied. After control period, patients ate 120-160 g/day of canned Pacific sardine (about 5 g omega-3 polyunsaturated fatty acids) per day. Two patients refused to participate after 2 months and 1 was lost for follow-up. After 7 months of diet, the proportion of eicosapentaenoic acid (EPA) in blood lipids increased from 0.67 + 0.26 to 4.7 + 1.5% (p < 0.015) and of docosahexaenoic acid (DHA) from 2.3 + 1.1 to 4.3 + 1.1% (p < 0.015). Ratio of EPA to arachidonic acid (AA) rose from 0.1 + 0.02 to 0.9 + 0.4 (p < 0.015). Mean serum triglyceride concentration fell after first month from 179.5 + 79.0 to 99.1 + 30.0 mg/dl (p < 0.015) and remained at this level throughout the study. No significant changes were observed in serum total and high-density lipoprotein cholesterol. Plasma activities of tissue-type plasminogen activator inhibitor, contents of plasminogen, alpha 2-antiplasmin, antithrombin III and protein C also did not change. Plasma fibrinogen moderately decreased. Its decrease became statistically significant at month 5 (from 3.8 + 0.5 to 3.0 + 0.7, p = 0.021). Thus, the regimen used in this study led to a substantial and steady increase in plasma EPA, DHA and EPA/AA ratio. This was accompanied by sustained decrease in plasma triglycerides. There were no profibrinolytic changes in the parameters studied.
authors.forename: M V
authors.initials: MV
authors.lastname: Pyzh
authors.forename: N A
authors.initials: NA
authors.lastname: Gratsianskiĭ
authors.forename: A B
authors.initials: AB
authors.lastname: Dobrovol'skiĭ
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005342:Fibrinolysis / Q000187:drug effects*; D005395:Fish Oils / Q000008:administration & dosage; D005527:Food, Fortified; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000178:diet therapy*; D005082:Physical Exertion / Q000187:drug effects; D013997:Time Factors
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins
vernacular_title: Vliianie dlitel'nogo primeneniia diety, obogashchennoĭ omega-3 polinenasyshchennymi zhirnymi kislotami, na zhirnokislotnyĭ sostav, pokazateli fibrinoliticheskoĭ sistemy i lipidnyĭ spektr krovi u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.