[Levels of endothelin and atrial natriuretic peptide (ANP) in plasma of patients with chronic renal failure treated by hemodialysis].
Two groups of subjects were studied. The group A consisted of 40 patients treated by HD (haemodialysis) (mean age--x +/- SEM 38.6 +/- 1.47 years, duration of haemodialysis treatment 36.8 +/- 3.7 months, cuprophan dialyzers and acetate containing solution--38 mEg/l--were used, time of HD--4 hours 3 times weekly, predialysis serum creatinine was 900.8 +/- 32.1 mumol/l (10.2 +/- 0.4 mg%) postdialysis serum creatinine was 467.8 +/- 28.3 mumol/l (5.3 +/- 0.3 mg%). Patients were not treated with erythropoietin. The control group comprised 20 healthy subjects (mean age 36.7 +/- 2.7 years and serum creatinine level 76.7 +/- 3.5 mumol/l (0.9 +/- 0.1 mg%). In all examined subjects the following experimental protocol was used. In both group blood pressure (BP) and heart rate (HR) were determined at about 8 a.m. after an overnight rest. Then blood samples were withdrawn for estimation of ANP, endothelin, haematocrit value (Ht), haemoglobin (Hb) and creatinine concentrations. Between 8 and 12 a.m. all examined subjects of the group A were dialysed. After each hour of dialysis BP and HR were measured and blood samples were withdrawn ANP (Peninsula Lab.Kids.) and endothelin (Amersham Kids) were measured using RIA methods, but other biochemical parameters using routine methods. Serum creatinine and plasma ANP levels significantly decreased after HD. Plasma endothelin level was significantly higher than in the control subjects. After first hour of HD a significant decrease of plasma endothelin was observed and than plasma endothelin level started to increase. No significant correalations between creatinine, ANP and endothelin levels in examined group was observed.
Kowalska
K
K
Zakład Medycyny Nuklearnej Woj. Szpitala Zespolonego w Kielcach kierownik.
Grzeszczak
W
W
Kowalski
D
D
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D003404:Creatinine / Q000097:blood; D016232:Endothelins / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D006435:Renal Dialysis
D016232:Endothelins; D009320:Atrial Natriuretic Factor; D003404:Creatinine
Stezenie endoteliny oraz przedsionkowego polipeptydu natriuretycznego (ANP) w osoczu u chorych z przewlekła niewydolnościa nerek leczonych hemodializami.