Expression of versican mRNA is developmentally regulated in the brain of the embryonic chick and the developing rat.
RNA prepared from the brains of chick embryos at 12 days of incubation contained a 12-kb transcript that hybridized with a cDNA probe for the aggregating proteoglycan versican. No transcripts were detected in the brains of newborn rats while, at 3 days of postnatal development, three sizes of transcripts were present. None were detected in the 6-day old brain and, at later stages, the smallest transcript predominated.
Crawford
T J
TJ
Department of Zoology, University of British Columbia, Vancouver, Canada.
Melhado
I G
IG
Jirik
F R
FR
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development* / Q000378:metabolism; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002642:Chick Embryo; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics*; D037181:Lectins, C-Type; D051379:Mice; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D053675:Versicans
D011508:Chondroitin Sulfate Proteoglycans; D037181:Lectins, C-Type; D012333:RNA, Messenger; C508323:Vcan protein, mouse; C508324:Vcan protein, rat; D053675:Versicans