title: Protection of the right ventricular myocardium during acute right heart failure from pulmonary hypertension.
abstract: Protection of the failing right ventricle (RV) in the surgical treatment of massive pulmonary embolism is a keystone for myocardial recovery. This study evaluated whether cardioplegia should be used or avoided. In a modified Langendorff rat heart model pulmonary embolism was simulated by afterload elevation (20 cm H2O) for 30 min. Hearts were arrested with cardioplegic solutions [St. Thomas Hospital (ST); University of Wisconsin (UW); oxygenated Krebs-Henseleit-Potassium (KHP)] and stored for 10 min or were allowed to beat empty (NoCP) for 15 min. After reestablishing of baseline conditions groups were measured for 60 min. Cardiac index (CI) decreased in all groups to 20% during afterload elevation. Group NoCP showed 68 and Group ST 65% recovery after 10 min and deteriorated after 30 min. After 60 min CI was 37 (ST) and 39% (NoCP). UW and KHP showed a significantly better recovery (KHP 100%; UW 88%). At 60 min CI decreased to 60 (KHP) and 64% (UW), but was still significantly higher than corresponding values of NoCP and ST. Following increased pulmonary afterload cardioplegia with UW or KHP solution is beneficial for RV recovery. The composition of the cardioplegia is obviously important and needs further study.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Surgical Center, Hannover Medical School, Hannover, FRG.
authors.forename: J M
authors.initials: JM
authors.lastname: Albes
authors.forename: R
authors.initials: R
authors.lastname: Rohde
authors.forename: A
authors.initials: A
authors.lastname: Haverich
mesh_terms: D000208:Acute Disease; D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D002314:Cardioplegic Solutions; D004195:Disease Models, Animal; D017128:Embolectomy; D005069:Evaluation Studies as Topic; D005112:Extracorporeal Circulation; D005947:Glucose; D005978:Glutathione; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D006976:Hypertension, Pulmonary / Q000150:complications*; D007328:Insulin; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D019188:Organ Preservation Solutions; D011655:Pulmonary Embolism / Q000601:surgery; D011887:Raffinose; D051381:Rats; D011917:Rats, Inbred Lew; D014325:Tromethamine; D016278:Ventricular Function, Right
chemical_list: D002314:Cardioplegic Solutions; D007328:Insulin; C074097:Krebs-Henseleit solution; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D014325:Tromethamine; D000493:Allopurinol; D005978:Glutathione; D005947:Glucose; D000241:Adenosine; D011887:Raffinose