Immunohistochemical and histological studies on internal derangement and organic disturbance of temporomandibular joint.
The study examined the articular cartilages of 14 patients who suffered from temporomandibular joint disturbance syndrome (TMJDS) and 3 healthy fresh cadavers by light microscopy and immunofluorescence, and assayed 14 patients' synovial fluids and sera with indirect hemoagglutination. The results showed that there were antibodies to type II collagen in synovial fluids in 5 of 14 patients and there were some immune complexes in cartilage. So, the authors think that there are autoimmune reactions in the articular tissues in TMJDS because of the exposure of some sequestered antigens.
Gu
Z Y
ZY
School of Stomatology, Beijing Medical University.
Zhang
Z K
ZK
Sun
K H
KH
Wu
Q G
QG
Xu
H C
HC
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000378:metabolism*; D002358:Cartilage, Articular / Q000473:pathology*; D003094:Collagen / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology; D008875:Middle Aged; D013582:Synovial Fluid / Q000276:immunology; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000276:immunology* / Q000473:pathology*
D001323:Autoantibodies; D003094:Collagen