title: Increase in c-erbA alpha 2 mRNA in the parvocellular region of the paraventricular nucleus of the hypothalamus following thyroidectomy in the adult male rat.
abstract: To examine thyroid hormone regulation of c-erbA alpha 2 mRNA expression in the parvo-cellular region of the paraventricular nucleus of the rat hypothalamus (pPVN), quantitative in situ hybridization was performed using 3H-labeled probe complementary to c-erbA alpha 2 mRNA. Thyroidectomy induced a significant increase in the number of silver grains overlying the cytoplasm in the pPVN relative to sham-operated controls. This effect was prevented by daily injection of thyroxine. These results indicate that hypothyroidism induced an increase in cellular c-erbA alpha 2 mRNA level in the pPVN.
authors.affiliation: Department of Physiology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Koibuchi
authors.forename: R B
authors.initials: RB
authors.lastname: Gibbs
authors.forename: K E
authors.initials: KE
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Yamaoka
authors.forename: W W
authors.initials: WW
authors.lastname: Chin
authors.forename: D W
authors.initials: DW
authors.lastname: Pfaff
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D017403:In Situ Hybridization; D008297:Male; D009857:Oncogenes / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016622:Silver Staining; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine