Paroxysmal cold hemoglobinuria associated with non-Hodgkin's lymphoma.
This report describes a patient with severe unexplained recurrent hemolytic anemia and congestive heart failure. Donath-Landsteiner antibodies, suggestive of paroxysmal cold hemoglobinuria (PCH), were detected. On postmortem examination, a diagnosis of non-Hodgkin's lymphoma, primarily involving the heart, was made. This previously undescribed association expands on the clinical and serologic spectrum of non-Hodgkin's lymphoma and PCH. Unexplained hemolytic anemia in the elderly should raise the suspicion of an underlying lymphoproliferative disorder.
Sharara
A I
AI
Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710.
Hillsley
R E
RE
Wax
T D
TD
Rosse
W F
WF
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006338:Heart Neoplasms / Q000150:complications* / Q000473:pathology; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000473:pathology