title: Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp.
abstract: The antimicrobial activity of 22 natural diterpenoids of endemic Sideritis from Eastern Andalusia (Spain) is described. Only ent-kaur-16-ene foliol and ent-beyer-15-ene isopusillatriol proved to be active towards Gram-positive and acid-fast bacteria. The introduction of a ketonic group at C-15 on ent-kaur-16-enic systems produced a remarkable degree of activity.
authors.affiliation: Department of Microbiology, University of Granada, Spain.
authors.forename: M E
authors.initials: ME
authors.lastname: Rodríguez-Linde
authors.forename: R M
authors.initials: RM
authors.lastname: Díaz
authors.forename: A
authors.initials: A
authors.lastname: García-Granados
authors.forename: J
authors.initials: J
authors.lastname: Quevedo-Sarmiento
authors.forename: E
authors.initials: E
authors.lastname: Moreno
authors.forename: M R
authors.initials: MR
authors.lastname: Onorato
authors.forename: A
authors.initials: A
authors.lastname: Parra
authors.forename: A
authors.initials: A
authors.lastname: Ramos-Cormenzana
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013030:Spain; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes