Evaluation of the mutagenicity of a-dihydroergocryptine in vitro and in vivo.
The mutagenic potential of the ergot alkaloid a-dihydroergocryptine (a-DEC, CAS 14271-05-7) was assessed in a series of 5 assays designed to measure gene mutation, chromosomal damage and primary DNA damage. All tests were carried out in accordance with appropriate EEC and OECD Guidelines. No indications of mutagenic potential were observed in any of the assays.
Adams
K
K
Department of Mutagenesis and Cell Biology, Huntingdon Research Centre Limited, Cambridgeshire, England.
Allen
J A
JA
Brooker
P C
PC
Jones
E
E
Proudlock
R J
RJ
Mailland
F
F
Coppi
G
G
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D016466:CHO Cells; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004088:Dihydroergotoxine / Q000633:toxicity*; D005260:Female; D005798:Genes, Bacterial / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014407:Tumor Cells, Cultured
D009153:Mutagens; D004088:Dihydroergotoxine; D004247:DNA