title: Binding of bovine transferrin by Pasteurella multocida serotype B:2,5, a strain which causes haemorrhagic septicaemia in buffalo and cattle.
abstract: Pasteurella multocida serotype B:2,5, which causes haemorrhagic septicaemia in buffalo and cattle, was examined for the presence of transferrin-binding proteins. An 82-kDa iron-regulated outer membrane protein was found which specifically binds bovine transferrin. In contrast, P. multocida serotype B:3,4, associated with haemorrhagic septicaemia in feral ruminants, did not express transferrin-binding proteins. These results might indicate a role for transferrin binding in the pathogenesis of haemorrhagic septicaemia in cattle and buffalo.
authors.affiliation: Department of Molecular Microbiology, BioCentrum Amsterdam, Vrije Universiteit, de Boelelaan, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Veken
authors.forename: B
authors.initials: B
authors.lastname: Oudega
authors.forename: J
authors.initials: J
authors.lastname: Luirink
authors.forename: F K
authors.initials: FK
authors.lastname: de Graaf
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002020:Buffaloes; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology; D006483:Hemorrhagic Septicemia / Q000382:microbiology; D016979:Pasteurella multocida / Q000737:chemistry* / Q000276:immunology / Q000472:pathogenicity; D011990:Receptors, Transferrin / Q000302:isolation & purification / Q000378:metabolism*; D012703:Serotyping; D013045:Species Specificity; D014168:Transferrin / Q000378:metabolism*; D014774:Virulence
chemical_list: D001425:Bacterial Outer Membrane Proteins; D011990:Receptors, Transferrin; D014168:Transferrin