[Prolactin inhibits gonadotropin-induced increase in ovarian plasminogen activator activity and ovulation in mouse].
We have demonstrated in this study that prolactin inhibits hCG-induced ovulation in PMSG-primed mice. At 18 h after the hormone treatment the number of ova in the oviducts was found to be 31.7 +/- 6.7 (mean +/- SE) in hCG treated group. The number was significantly decreased (19.7 +/- 4.9) when 100 micrograms of prolactin was injected simultaneously. The same effect of PRL on hCG induced ovulation could be also observed at 24 h after the hormone treatment; the values reached respectively to 32.3 +/- 10.8 and 20.3 +/- 5.4. Both in vivo and in vitro experiments further showed that the inhibition of the gonadotropin-induced ovulation by PRL is mediated through decreasing in the ovarian plasminogen activator activity.
Hu
Z Y
ZY
Laboratory of Reproductive Biology, Chinese Academy of Sciences, Beijing.
Liu
Y X
YX
D000818:Animals; D006063:Chorionic Gonadotropin; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism; D051379:Mice; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D010960:Plasminogen Activators / Q000378:metabolism*; D011388:Prolactin / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D011388:Prolactin; D010960:Plasminogen Activators