[Hypersensitivity interstitial pneumopathy and ulcero-hemorrhagic rectocolitis: role of methotrexate].
The authors report the case of a 46-year-old man with refractory ulcerative colitis treated with methotrexate who was admitted in the hospital for asthenia, fever, cough and dyspnea. Owing to the development of adult respiratory distress syndrome despite broad spectrum antibiotherapy, the patient was transferred to the intensive care unit. A diagnosis of pneumonitis due to methotrexate was made. Patient's condition improved after discontinuation of the drug, mechanical ventilation, and corticosteroids. The increasing use of methotrexate in several gastroenterological diseases warrants further consideration of the potential devastating side effects of this drug, particularly on the lungs. A review of the literature on this topic is provided in the "discussion" section.
Bohon
P
P
Service de Soins Intensifs, Clinique St-Pierre, Ottignies.
Dugernier
T
T
Debongnie
J C
JC
Pirenne
B
B
D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
D008775:Methylprednisolone; D008727:Methotrexate
Pneumopathie interstitielle d'hypersensibilité et rectocolite ulcéro-hémorragique: rôle du methotrexate.