Postnatal differentiation and development of the rat epididymis: a stereological study.
Postnatal development and differentiation of the rat epididymis was studied in the rat from 15 to 120 days of life using stereological techniques. Both the relative volume (volume density) and absolute volume of the epithelial, interstitial, and luminal compartments in the initial segment, caput, corpus, and cauda epididymides were determined. In all segments the volume density of the epithelial compartment increased between days 15 and 30 before falling to adult values at 45 days in the initial segment (0.476 +/- 0.031), at 60 days in the caput (0.258 +/- 0.028) and at 90 days in the corpus (0.245 +/- 0.007) and cauda (0.140 +/- 0.004). The relative volume of the interstitium decreased, whilst that of the lumen increased over the same period with adult values being achieved earlier in the proximal segments than in the distal segments. In contrast to volume fraction the absolute volume of all compartments in all segments increased from day 15 to day 90. Between 90 and 120 days the absolute volumes of compartments in the initial segment and caput showed little volume change. All compartments in the corpus and cauda showed significant increases in volume over the same period. A similar pattern of development was observed with respect to the surface area of both the luminal and basement membrane aspects of the epithelium; surface area per unit volume (surface density) in all segments reached adult values at approximately 60 days, whilst the increase in absolute area of the surfaces ceased at 90 days in the initial segment and caput and continued to 120 days in the corpus and cauda.(ABSTRACT TRUNCATED AT 250 WORDS)
Jiang
F X
FX
Department of Anatomy, Monash University, Clayton, Vic, Australia.
Temple-Smith
P
P
Wreford
N G
NG
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001485:Basement Membrane / Q000648:ultrastructure; D004822:Epididymis / Q000254:growth & development*; D004848:Epithelium / Q000254:growth & development; D008297:Male; D051381:Rats / Q000254:growth & development*; D017207:Rats, Sprague-Dawley