[Methodologic study of the stability of intravenous nutritive emulsions].
Stability studies are one of the main steps of emulsion development, since emulsions are thermodynamically unstable systems. This is even more critical for drugs, and especially for nutritive parenteral emulsions considering the large volumes which are infused to patients. Physico-chemical stability of emulsions can be estimated, either under real storage conditions, or using accelerated testing that are of great interest in formulation. After a literature review of stability testing applied to emulsions, we give an example of procedure which is especially useful for intravenous nutritive emulsions.
Koycha
M
M
Laboratoire de Pharmacie Galénique, Faculté de Pharmacie de Grenoble, France.
Harraki
B
B
Rochat-Gonthier
M H
MH
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004655:Emulsions; D006801:Humans; D010288:Parenteral Nutrition
D004655:Emulsions
Méthodologie d'étude de la stabilité des émulsions nutritives intraveineuses.