title: Late recurrence of testicular cancer.
abstract: Late recurrence of nonseminomatous germ cell tumours of the testis is rare. The authors report on a 35-year-old man treated initially for embryonal cell carcinoma of the testis with metastases, who presented 12 years later with an increasing serum alpha-fetoprotein level and a biopsy-proven embryonal cell cancer in the hilus of the left lung. Because the tumour was highly resistant to two separate courses of cis-platinum-based chemotherapy and one course of radiotherapy, surgical resection for salvage was carried out. The patient was free of disease 3.5 years after the second operation. The possible reasons for the occurrence of this highly resistant metastatic testicular cancer are discussed. They include a second primary tumour and malignant degeneration of the original tumour. In this patient the latter cause was the most plausible.
authors.affiliation: Department of Medicine, University of Manitoba, Winnipeg.
authors.forename: J M
authors.initials: JM
authors.lastname: Embil
authors.forename: B H
authors.initials: BH
authors.lastname: Weinerman
authors.forename: E A
authors.initials: EA
authors.lastname: Pascoe
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018240:Endodermal Sinus Tumor / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009919:Orchiectomy; D011182:Postoperative Care; D011879:Radiotherapy Dosage; D016879:Salvage Therapy; D013736:Testicular Neoplasms / Q000473:pathology / Q000628:therapy*; D013997:Time Factors