Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp.
The antimicrobial activity of 22 natural diterpenoids of endemic Sideritis from Eastern Andalusia (Spain) is described. Only ent-kaur-16-ene foliol and ent-beyer-15-ene isopusillatriol proved to be active towards Gram-positive and acid-fast bacteria. The introduction of a ketonic group at C-15 on ent-kaur-16-enic systems produced a remarkable degree of activity.
Rodríguez-Linde
M E
ME
Department of Microbiology, University of Granada, Spain.
Díaz
R M
RM
García-Granados
A
A
Quevedo-Sarmiento
J
J
Moreno
E
E
Onorato
M R
MR
Parra
A
A
Ramos-Cormenzana
A
A
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013030:Spain; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes