title: Anti-inflammatory ketoprofen in the treatment of field cases of bovine mastitis.
abstract: The efficacy of ketoprofen in the treatment of acute clinical mastitis was evaluated in a clinical trial comprising a non-blind controlled study and a blind, placebo-controlled study. All the cows were treated with 20 g sulphadiazine and 4 g trimethoprim intramuscularly upon diagnosis, and half the dosage was given once daily thereafter. In addition, the ketoprofen treatment groups received 2 g ketoprofen intramuscularly once daily for the duration of the antimicrobial therapy. Recovery rates for the non-blind contemporary controls and the blind placebo-controls were 83.7 per cent and 70.7 per cent, respectively. In the non-blind controlled ketoprofen and the placebo-controlled ketoprofen treatment groups, recovery rates were 94.7 per cent and 92.3 per cent, respectively. The odds ratio (OR) of recovery was significantly (P < or = 0.01) high in the placebo-controlled study (OR = 6.75, confidence interval [CI] = 1.45 to 31.4), and high but not significant in the non-blind controlled study (OR = 2.64, CI = 0.53 to 13.10). It was concluded that ketoprofen significantly improved recovery in clinical mastitis in dairy cows.
authors.affiliation: Hachaklait Veterinary Services, Hebrew University of Jerusalem, Israel.
authors.forename: N Y
authors.initials: NY
authors.lastname: Shpigel
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Winkler
authors.forename: A
authors.initials: A
authors.lastname: Saran
authors.forename: G
authors.initials: G
authors.lastname: Ziv
authors.forename: F
authors.initials: F
authors.lastname: Longo
mesh_terms: D000818:Animals; D002417:Cattle; D004338:Drug Combinations; D005260:Female; D007660:Ketoprofen / Q000627:therapeutic use*; D008414:Mastitis, Bovine / Q000188:drug therapy*; D016037:Single-Blind Method; D013411:Sulfadiazine / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D000096926:Benzenesulfonamides
chemical_list: D004338:Drug Combinations; D007660:Ketoprofen; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides