title: [Effects of the monosaccharide derivative 8RN-DAGal on the putative P-type calcium channel expressed in Xenopus oocytes].
abstract: P-type calcium channels are expressed in Xenopus oocytes after injection of rat cerebellar mRNA. The FTX and omega-Aga-IVa toxins extracted from Agelenopsis aperta venom are known to inhibit the activity of this channel. The present results demonstrate that 8RN-DAGal is also a antagonist of P-type calcium channels. The inhibition of the current, obtained with Ba2+, as charge carrier, is voltage dependent.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire, Université de Picardie Jules Verne, Faculté des Sciences, Amiens, France.
authors.forename: F
authors.initials: F
authors.lastname: Fournier
authors.forename: G
authors.initials: G
authors.lastname: Charpentier
authors.forename: A
authors.initials: A
authors.lastname: Lahyani
authors.forename: J
authors.initials: J
authors.lastname: Bruner
authors.forename: G
authors.initials: G
authors.lastname: Czternasty
authors.forename: D
authors.initials: D
authors.lastname: Marlot
authors.forename: G
authors.initials: G
authors.lastname: Ronco
authors.forename: P
authors.initials: P
authors.lastname: Villa
authors.forename: G
authors.initials: G
authors.lastname: Brule
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D005690:Galactose / Q000031:analogs & derivatives* / Q000494:pharmacology; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D014981:Xenopus
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D012333:RNA, Messenger; C086353:6-desoxy-6-n-octylamino-1,2-3,4-di-O-isopropylidenegalactopyranose; D005690:Galactose
vernacular_title: Effets du dérivé monosaccharidique 8RN-DAGal sur un courant calcique apparenté au type P exprimé dans l'ovocyte de Xénope.