The effect of a cyclooxygenase inhibitor on the in vivo polymorphonuclear leukocyte migration to Pseudomonas aeruginosa peptide chemotactins.
Pseudomonas aeruginosa chemotactic peptides (PAPCs) induced migration of polymorphonuclear leukocytes (PMNL) into the lungs when administered by the aerosol route. Migration of PMNL into the lungs and total protein content of lung lavage fluids in response to PAPCs aerosol challenge, and mortality from lethal challenge with P. aeruginosa were decreased by piroxicam treatment.
Fontán
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PA
Departamento de Microbiología, Parasitología and Immunología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Amura
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CR
Sordelli
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DO
D000336:Aerosols; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D002630:Chemotactic Factors / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003470:Culture Media; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D008168:Lung / Q000166:cytology / Q000187:drug effects; D051379:Mice; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D010894:Piroxicam / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000737:chemistry*
D000336:Aerosols; D002630:Chemotactic Factors; D003470:Culture Media; D016861:Cyclooxygenase Inhibitors; D010894:Piroxicam; D009240:N-Formylmethionine Leucyl-Phenylalanine