BW-A522 blocks adenosine A3 receptor-mediated hypotensive responses in the rat.
The effects of 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)-1-propylxanthine (I-ABOPX; BW-A522), which has nanomolar affinity for the recently cloned human and sheep adenosine A3 receptor, on the putative A3 receptor mediated hypotensive response to N6-2-(4-aminophenyl)ethyl adenosine (APNEA) in the rat have been investigated. Following blockade of A1 and A2 receptors with 8-(p-sulphophenyl)theophylline, BW-A522, 10 and 40 mg/kg i.v., blocked dose-dependently and surmountable the hypotensive response to APNEA. The results provide direct evidence of an A3 receptor in the cardiovascular system of the rat which induces hypotension when activated.
Fozard
J R
JR
Sandoz Pharma Ltd., Basel, Switzerland.
Hannon
J P
JP
D000241:Adenosine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008297:Male; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology*
C086112:N(6)-2-(4-aminophenyl)ethyladenosine; D058915:Purinergic P1 Receptor Antagonists; D014970:Xanthines; C086749:BW A522; C031433:8-(4-sulfophenyl)theophylline; D013806:Theophylline; D000241:Adenosine