title: Immunophenotyping of acute lymphoblastic leukaemia in Madras, India.
abstract: At the Cancer Institute, Madras, India, we have performed immunophenotyping in 125 untreated cases of acute lymphoblastic leukaemia using a panel of 16 monoclonal antibodies and the avidin-biotin immunoperoxidase technique in a haematology autoanalyser (Technicon Hi system). Our results demonstrate a marked difference in the phenotypic pattern of ALL compared to Western countries, the predominant finding being a relative excess of T-ALL and a paucity of C-ALL cases. Age distribution of C-ALL reveals a peak at 2-6 years in paediatric ALL cases.
authors.affiliation: Haematology/Immunology Division, Cancer Institute, Adyar, Madras, South India.
authors.forename: K R
authors.initials: KR
authors.lastname: Rajalekshmy
authors.forename: A R
authors.initials: AR
authors.lastname: Abitha
authors.forename: R
authors.initials: R
authors.lastname: Pramila
authors.forename: T
authors.initials: T
authors.lastname: Gnanasagar
authors.forename: V
authors.initials: V
authors.lastname: Maitreyan
authors.forename: V
authors.initials: V
authors.lastname: Shanta
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001322:Autoanalysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000276:immunology; D017678:Sex Distribution; D012959:Socioeconomic Factors