title: The use of subconjunctivally administered tissue plasminogen activator after trabeculectomy.
abstract: Blockage of aqueous flow in the early postoperative period can be devastating to the success of trabeculectomy. We used tissue plasminogen activator (tPA) subconjunctivally in an attempt to release a trabeculectomy flap that appeared to be adherent to its scleral bed. No change was noted 90 minutes after injection, but a highly elevated bleb was present on the first postoperative day. Subconjunctivally administered tPA may be useful in releasing the fibrin "glue" in cases with adherent trabeculectomy flaps.
authors.affiliation: Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104.
authors.forename: J R
authors.initials: JR
authors.lastname: Piltz
authors.forename: R J
authors.initials: RJ
authors.lastname: Starita
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism; D003228:Conjunctiva / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007267:Injections; D011994:Recombinant Proteins; D012590:Sclera; D013524:Surgical Flaps; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014130:Trabeculectomy / Q000009:adverse effects
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator