Intracytoplasmic lumina in a case of bilaterally multifocal renal oncocytomas.
We report a case of bilaterally multifocal renal oncocytomas in a patient with chronic renal disease and a long history of hypertension. Histologic study of the multiple oncocytic neoplasms with hematoxylin-eosin, periodic acid-Schiff, trichrome, and colloidal iron stains revealed novel, intracytoplasmic lumina, which were accentuated by immunoperoxidase staining with high-molecular-weight cytokeratin, epithelial membrane antigen, and Arachis hypogaea lectin. Ultrastructural studies demonstrated multiple microvilli lining the intracytoplasmic lumina. We also review the literature on bilaterally multifocal oncocytomas.
Lyzak
J S
JS
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston.
Farhood
A
A
Verani
R
R
D018249:Adenoma, Oxyphilic / Q000150:complications / Q000473:pathology*; D000328:Adult; D003593:Cytoplasm / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000150:complications / Q000473:pathology*; D008854:Microscopy, Electron