A family of cellular proteins related to snake venom disintegrins.
Disintegrins are short soluble integrin ligands that were initially identified in snake venom. A previously recognized cellular protein with a disintegrin domain was the guinea pig sperm protein PH-30, a protein implicated in sperm-egg membrane binding and fusion. Here we present peptide sequences that are characteristic for several cellular disintegrin-domain proteins. These peptide sequences were deduced from cDNA sequence tags that were generated by polymerase chain reaction from various mouse tissue and a mouse muscle cell line. Northern blot analysis with four sequence tags revealed distinct mRNA expression patterns. Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions.
Weskamp
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Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Blobel
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CP
D051722:ADAM Proteins; D000595:Amino Acid Sequence; D000818:Animals; D016384:Consensus Sequence; D019483:Disintegrins; D000072196:Fertilins; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008666:Metalloendopeptidases; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010455:Peptides / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014688:Venoms / Q000235:genetics*
D019483:Disintegrins; D008562:Membrane Glycoproteins; D010455:Peptides; D012333:RNA, Messenger; D014688:Venoms; D051722:ADAM Proteins; D000072196:Fertilins; D008666:Metalloendopeptidases