title: Frusemide attenuates the exercise-induced rise in pulmonary capillary blood pressure in horses.
abstract: Catheter mounted micro-tip-manometers (the signals from which were matched with fluid-filled pressure signals from same cardiovascular sites and zeroed at the point of the shoulder), were used to study pulmonary haemodynamics in 8 healthy sound horses at rest and during exercise performed at 8, 10, 12 and 14 m/s on a treadmill. Measurements were made without frusemide (control) and 4 h after iv administration of 250 mg frusemide. Post-frusemide data were also obtained on a separate day, and these observations were not significantly different from those made on the same day as controls. Pre-frusemide values of heart rate, mean right atrial pressure, mean pulmonary artery pressure, mean pulmonary artery wedge pressure and mean pulmonary capillary pressure at 14 m/s were 214 +/- 5 beats/min, 54 +/- 4, 92 +/- 4, 65 +/- 6 and 79 +/- 5 mmHg, respectively. Exercise at 14 m/s after frusemide resulted in a similar heart rate (216 +/- 4 beats/min), but the mean right atrial, pulmonary arterial, pulmonary artery wedge and pulmonary capillary pressures were all significantly lower, i.e. 34 +/- 5, 79 +/- 4, 45 +/- 4, and 62 +/- 3 mmHg, respectively. Attenuation, by frusemide, of the exercise-induced rise in pulmonary capillary pressure would lower the magnitude of the transmural force exerted on the pulmonary capillaries. If, therefore, exercise-induced pulmonary haemorrhage (EIPH) is caused by stress failure of pulmonary capillaries, frusemide pretreatment has the potential for reducing/limiting the extent of EIPH.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign 61801.
authors.forename: M
authors.initials: M
authors.lastname: Manohar
authors.forename: E
authors.initials: E
authors.lastname: Hutchens
authors.forename: E
authors.initials: E
authors.lastname: Coney
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects / Q000502:physiology; D005080:Exercise Test / Q000662:veterinary; D005665:Furosemide / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D008168:Lung / Q000098:blood supply* / Q000187:drug effects; D005082:Physical Exertion / Q000502:physiology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects*
chemical_list: D005665:Furosemide