title: Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity.
abstract: Hb Cemenelum [alpha 92 (FG4) Arg-->Trp] carries a structural modification at the same position as Hb Chesapeake, a very high oxygen affinity variant. Hb Cemenelum was found in a French diabetic patient with no abnormal hematological features. The purified abnormal hemoglobin, like Hb J Cape Town, another variant of position alpha 92(FG4), displayed only a 1.5- to 2-fold increased oxygen affinity and a reduced cooperativity. This hemoglobin demonstrates that, even for some key residues of the alpha 1/beta 2 interface, the degree at which the functional properties are altered depends upon the specific residue occupying this position.
authors.affiliation: INSERM U299, Hôpital de Bicêtre, Le Kremlin, France.
authors.forename: H
authors.initials: H
authors.lastname: Wajcman
authors.forename: J
authors.initials: J
authors.lastname: Kister
authors.forename: A
authors.initials: A
authors.lastname: M'Rad
authors.forename: A M
authors.initials: AM
authors.lastname: Soummer
authors.forename: F
authors.initials: F
authors.lastname: Galacteros
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004586:Electrophoresis; D005260:Female; D006454:Hemoglobins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; C086688:hemoglobin Cemenelum; D010100:Oxygen