title: Evolution of the human immunodeficiency virus type 2 envelope gene in preimmunized and persistently infected rhesus macaques.
abstract: The V3 and V4 domains of human immunodeficiency virus type 2 (HIV-2) env genes from 14 rhesus macaques experimentally infected by HIV-2 SBL6669/H5 were sequenced. No variation was observed in viral sequences from sera and from uncultured peripheral blood mononuclear cells during primary infection. The first mutations were detected 17 months after infection; they mainly concerned the region between the V3 and V4 domains and not those domains themselves, which are known to be hypervariable, suggesting that variation of V3 is a late event of HIV infection.
authors.affiliation: Laboratoire de Neuropathologie Expérimentale et Neurovirologie, Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France.
authors.forename: M H
authors.initials: MH
authors.lastname: Bäyon-Auboyer
authors.forename: F D
authors.initials: FD
authors.lastname: Boussin
authors.forename: G
authors.initials: G
authors.lastname: Vogt
authors.forename: R
authors.initials: R
authors.lastname: Le Grand
authors.forename: B
authors.initials: B
authors.lastname: Vaslin
authors.forename: I
authors.initials: I
authors.lastname: Nicol-Jourdain
authors.forename: D
authors.initials: D
authors.lastname: Dormont
mesh_terms: D016915:AIDS Vaccines; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002986:Clinical Trials as Topic; D015752:Genes, env / Q000235:genetics*; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015658:HIV Infections / Q000097:blood* / Q000517:prevention & control; D015498:HIV-2 / Q000235:genetics*; D006801:Humans; D007114:Immunization; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008137:Longitudinal Studies; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008264:Macrophages / Q000382:microbiology; D008969:Molecular Sequence Data; D016296:Mutagenesis; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D016915:AIDS Vaccines; D015699:HIV Envelope Protein gp120