A dual embryonic origin for vertebrate mechanoreceptors.
Neuromasts, the mechanoreceptors of the lateral line system of fishes and aquatic amphibians, have previously been thought to develop exclusively from embryonic epidermal placodes. Use of fate mapping techniques shows that neuromasts of the head and body of zebrafish, Siamese fighting fish, and Xenopus are also derived from neural crest. Neural crest migrates away from the neural tube in developing vertebrates to form much of the peripheral nervous system, pigment cells, and skeletal elements of the head. The data presented here demonstrate that neuromasts are derived from both neural crest and epidermal placodes.
Collazo
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Division of Biology, Beckman Institute, California Institute of Technology, Pasadena 91125.
Fraser
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Mabee
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PM
D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D002490:Central Nervous System / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000166:cytology; D000078404:Epidermal Cells; D004817:Epidermis / Q000196:embryology*; D005399:Fishes / Q000196:embryology*; D005456:Fluorescent Dyes; D008465:Mechanoreceptors / Q000196:embryology*; D009432:Neural Crest / Q000166:cytology / Q000196:embryology*; D017933:Peripheral Nervous System / Q000196:embryology; D014981:Xenopus / Q000196:embryology*; D015027:Zebrafish / Q000196:embryology
D005456:Fluorescent Dyes