title: Modification of glycopeptide antibiotic eremomycin by the action of alkyl halides and study on antibacterial activity of the compounds obtained.
abstract: Alkylation of glycopeptide antibiotic eremomycin by the action of different alkyl halides leads, depending on the structure of alkyl halides used, to eremomycin derivatives of six types; alkylated at the N-terminus, quaternary compounds at the N-terminus, eremomycin esters, esters of eremocycin alkylated at the N-terminus, esters of eremomycin quaternised at the N-terminus, esters of eremomycin alkylated both at the N-terminus and at the aminogroup of disaccharide branch. Five compounds demonstrated high antibacterial activity in vitro, N-allyleremomycin and methyl ester of N,N-dimethyleremomycin being at least as good as the parent eremomycin.
authors.affiliation: Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow.
authors.forename: A Y
authors.initials: AY
authors.lastname: Pavlov
authors.forename: E N
authors.initials: EN
authors.lastname: Olsufyeva
authors.forename: T F
authors.initials: TF
authors.lastname: Berdnikova
authors.forename: I V
authors.initials: IV
authors.lastname: Malkova
authors.forename: M N
authors.initials: MN
authors.lastname: Preobrazhenskaya
authors.forename: G D
authors.initials: GD
authors.lastname: Risbridger
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D006846:Hydrocarbons, Halogenated; C053759:eremomycin