Physiological consequences of loss of plasminogen activator gene function in mice.
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.
Carmeliet
P
P
Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142.
Schoonjans
L
L
Kieckens
L
L
Ream
B
B
Degen
J
J
Bronson
R
R
De Vos
R
R
van den Oord
J J
JJ
Collen
D
D
Mulligan
R C
RC
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology; D005337:Fibrin / Q000502:physiology; D005342:Fibrinolysis / Q000235:genetics / Q000502:physiology*; D006128:Growth / Q000235:genetics / Q000502:physiology; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D051379:Mice; D016296:Mutagenesis; D010960:Plasminogen Activators / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D013234:Stem Cells; D013927:Thrombosis / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000172:deficiency / Q000235:genetics / Q000502:physiology
D005337:Fibrin; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator