title: [Poor results of treatment of echinococcosis with albendazole in 7 patients].
abstract: OBJECTIVE
  To assess the effect of treatment of echinococcal disease with albendazole, a drug recently licensed in the Netherlands for this treatment.
  
  
  METHODS
  The University Hospital Utrecht and the Wilhelmina Children's Hospital, Utrecht.
  
  
  METHODS
  Follow-up study.
  
  
  METHODS
  Clinical symptoms, serology and size and morphology of cysts of all patients (n = 7) treated with albendazole with a therapeutical dose (10 mg/kg for adults and 6 mg/kg for children in two daily doses during three cycles of 28 days) were monitored for at least one year.
  
  
  RESULTS
  Two patients improved, two patients did not show any change, and the condition of three patients deteriorated.
  
  
  CONCLUSIONS
  The efficacy of albendazole treatment with this regimen for hydatid disease is disappointing. If patients are treated with albendazole, the total dose administered to adults should be more than 80 g.
authors.affiliation: Academisch Ziekenhuis, Eijkman-Winkler Laboratorium voor Medische Microbiologie, Utrecht.
authors.forename: P M
authors.initials: PM
authors.lastname: Schneeberger
authors.forename: L M
authors.initials: LM
authors.lastname: Kortbeek
authors.forename: M M
authors.initials: MM
authors.lastname: Schneider
authors.forename: S P
authors.initials: SP
authors.lastname: Geelen
authors.forename: M S
authors.initials: MS
authors.lastname: van Leeuwen
authors.forename: I M
authors.initials: IM
authors.lastname: Hoepelman
mesh_terms: D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000601:surgery; D004445:Echinococcosis, Pulmonary / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D015766:Albendazole
vernacular_title: Matig resultaat van behandeling van echinokokkose met albendazol bij 7 patiënten.