[Changes in oxygen free radical and prostacyclin in thromboangiitis obliterans and its relationship with syndrome differentiation].
Malondialdehyde (MDA) and 6-keto-PGF1 alpha levels in plasma and erythrocyte superoxide dismutase activities (Ery-SODA) were observed in 56 cases of thromboangiitis obliterans (TAO). The results showed that: (1) Ery-SODA and 6-keto-PGF1 alpha levels lowered and MDA raised significantly in TAO (P < 0.01), compared with that in control. (2) 6-keto-PGF1 alpha levels were markedly related with Ery-SODA and MDA in TAO (P < 0.01). (3) Ery-SODA and 6-keto-PGF1 alpha levels were lower and MDA higher in III phase of TAO than that in II phase. (4) Ery-SODA and 6-keto-PGF1 alpha levels markedly declined and MDA contents elevated significantly in Dampness-Heat (DH) and Heat-Toxin (HT) group, compared with that in Yin-Cold (YC) group and Blood-Stasis (BS) group, respectively (P < 0.05, P < 0.01); all above substances between YC and BS group or between DH and HT group had no significant differences (P > 0.05). (5) Ery-SODA and 6-keto-PGF1 alpha levels were lower and MDA higher in Heat Syndrome than that in Cold Syndrome (P < 0.01). It suggested that oxygen free radical and lipid peroxide response that might participate in vascular endothelial cell injury in TAO markedly increased and the detection of these substances might provide complementary evidences for syndrome differentiation of TAO.
Ge
J W
JW
Hunan College of TCM, Changsha.
Jiang
Y P
YP
He
S L
SL
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D003937:Diagnosis, Differential; D011464:Epoprostenol / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008516:Medicine, Chinese Traditional; D013482:Superoxide Dismutase / Q000097:blood; D013919:Thromboangiitis Obliterans / Q000378:metabolism*
D005609:Free Radicals; D008315:Malondialdehyde; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D013482:Superoxide Dismutase