Ageing and acetylcholine release by tityustoxin from brain cortical slices.
The ability of tityustoxin to trigger acetylcholine release was studied in cerebral cortical slices from 2, 12 and 23-month-old rats. The effect of tityustoxin to induce the release of acetylcholine was reduced by 60% in senescent animals. This result suggests that ageing reduces the sensitivity of cerebral cortical nerve terminals to tityustoxin.
Queiroz
I B
IB
Departamento de Farmacologia, Faculdade, de Farmácia, Instituto de Ciências Biológicas-UFMG, Belo Horizonte, Brazil.
Turchetti-Maia
R M
RM
Moraes-Santos
T
T
Gomez
M V
MV
D000109:Acetylcholine / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*
D012604:Scorpion Venoms; C003609:tityustoxin; D000109:Acetylcholine