[The antiviral action of recombinant receptorotoxins based on the diphtheria toxin and the human T-lymphocyte CD4-receptor].
A number of vectors expressing in E. coli hybrid proteins (receptorotoxins) composed of diphtheria toxin lacking the C-terminal region and CD4-receptor fragment including N-terminal region of the natural protein have been constructed. The receptorotoxins consisting of the CD4 fragment in their N-terminal region were more stable. These recombinant receptorotoxins were cultured with HIV-infected Hut-78 cells and were shown to block HIV infection in vitro.
Sidorov
A V
AV
Zverev
V V
VV
Zdanovskiĭ
A G
AG
Pugach
A V
AV
Maliushova
V V
VV
Andzhaparidze
O G
OG
D000998:Antiviral Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D015704:CD4 Antigens / Q000235:genetics / Q000494:pharmacology*; D002460:Cell Line; D004167:Diphtheria Toxin / Q000235:genetics / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D005822:Genetic Vectors / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D010957:Plasmids / Q000235:genetics; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology; D014776:Virus Cultivation
D000998:Antiviral Agents; D001426:Bacterial Proteins; D015704:CD4 Antigens; D004167:Diphtheria Toxin; D011994:Recombinant Proteins
Protivovirusnoe deĭstvie rekombinantnykh retseptorotoksinov na osnove difteriĭnogo toksina i CD4-retseptora T-limfotsitov cheloveka.