[Therapeutic effect of lisuride maleate on post-stroke depression].
Twenty post-stroke depressive patients who obtained more than 11 points on Self-Rating Questionnaire for Depression, were treated with 0.075 mg/day lisuride maleate for 12 weeks. The drug effect on depression was evaluated quantitatively by the Hamilton Rating Scale for Depression. The relationships between brain CT or MRI and SRQ-D score were investigated in 24 subjects. More than 80% of post-stroke depressive patients improved after lisuride maleate treatment for 8 or 12 weeks. In particular, depressed mood, hypobulia, sleep disturbance, anxiety, etc. were significantly improved compared to the baseline condition. As for the relationships with CT and/or MRI findings, the group with moderate to severe brain atrophy had a significantly higher grade of depressive state than those without.
Hougaku
H
H
First Department of Medicine, Osaka University Medical School.
Matsumoto
M
M
Hata
R
R
Handa
N
N
Imaizumi
M
M
Sugitani
Y
Y
Yoneda
S
S
Etani
H
H
Sueyoshi
K
K
Kusunoki
M
M
D000368:Aged; D002561:Cerebrovascular Disorders / Q000150:complications*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008090:Lisuride / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D008090:Lisuride