Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
Mierzwa
R
R
Schering Plough Research Institute, Kenilworth, New Jersey 07033.
King
A
A
Conover
M A
MA
Tozzi
S
S
Puar
M S
MS
Patel
M
M
Coval
S J
SJ
Pomponi
S A
SA
D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010091:Oximes / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D006633:Histamine Antagonists; D010091:Oximes; C086787:verongamine; D014443:Tyrosine; D003000:Clonidine