Lack of effect of quinidine on divalent mineral absorption from the reticulorumen of sheep.
The effects of quinidine on divalent mineral absorption were studied using normal and high potassium intraruminal buffers with the in vivo isolated washed rumen technique. A concentration of 1 mmol litre-1 quinidine in the intraruminal buffer decreased the absorption rates of Na+ and C1- from the rumen but had no significant effect on the absorption rates of Mg2+, Ca2+ and K+. Prolonged oral administration of quinidine had no significant effect on the absorption of any of these ions from either a normal or a high potassium ruminal solution.
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Department of Biochemistry, University of Wales, Aberystwyth.
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D000818:Animals; D002413:Cations, Divalent / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D008903:Minerals / Q000378:metabolism*; D011802:Quinidine / Q000494:pharmacology*; D012417:Rumen / Q000187:drug effects* / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*
D002413:Cations, Divalent; D008903:Minerals; D011802:Quinidine