Phencyclidine reduces inherited neocortical spindling in DBA/2J mice.
The role of phencyclidine (PCP) in the control of the spike-and-wave spindling episodes (S&W) which can be spontaneously recorded in the electrocorticogram (ECoG) of DBA/2J mice was investigated. PCP (0.1-0.5-1.0-5.0 mg/kg/i.p.) dose dependently reduced both S&W number and duration of DBA/2J mice. PCP reduction is significant 30-60 min after drug administration and lasts for the whole duration of the recording period (240 min). These results suggest that PCP may play an important regulatory role on brain excitability.
Capasso
A
A
School of Pharmacy, University of Salerno, Italy.
Di Giannuario
A
A
Loizzo
A
A
Pieretti
S
S
Sorrentino
L
L
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010622:Phencyclidine / Q000494:pharmacology* / Q000627:therapeutic use
D010622:Phencyclidine