title: [Acute monoblastic leukemia (M5a) with dysmegakaryocytopoiesis associated with t(16;21) (p11;q22)].
abstract: We report a 24-year-old woman who had acute monoblastic leukemia associated with t(16;21) (p11;q22). She was referred to our hospital in April 1992 because of high fever and hemorrhagic diathesis. Physical examination on admission showed no hepatosplenomegaly. The hemoglobin was 5.1g/dl, platelet count 1.7 x 10(4)/microliters, the white blood cell count 18,700/microliters. Bone marrow aspirate showed that 86% of nucleated cells were monoblasts which were positive for peroxidase and alpha-naphtyl butyrate esterase. She was diagnosed as having M5a. Dysmegakaryopoiesis, such as micromegakaryocytes and megakaryocytes with multiple small separated nuclei, was seen in the bone marrow. Chromosomal analysis revealed t(16;21). Complete remission was achieved after two courses of BHAC-DMP therapy, but dysmegakaryopoietic features remained. She relapsed in September 1992. Review of the literature and this patient indicate that acute nonlymphocytic leukemia with t(16;21) is associated with multilineage leukemic differentiation.
authors.affiliation: Third Department of Internal Medicine, Akita University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: I
authors.initials: I
authors.lastname: Miura
authors.forename: A
authors.initials: A
authors.lastname: Chubachi
authors.forename: H
authors.initials: H
authors.lastname: Ohtani
authors.forename: M
authors.initials: M
authors.lastname: Hirokawa
authors.forename: H
authors.initials: H
authors.lastname: Niitsu
authors.forename: A B
authors.initials: AB
authors.lastname: Miura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D003561:Cytarabine / Q000008:administration & dosage / Q000031:analogs & derivatives; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008533:Megakaryocytes / Q000473:pathology*; D015122:Mercaptopurine / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D014178:Translocation, Genetic
chemical_list: D003561:Cytarabine; D011239:Prednisolone; D015122:Mercaptopurine; D003630:Daunorubicin