title: Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain.
abstract: The distribution of DNase I hypersensitive sites upstream of the chicken alpha-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5-14.5 kb upstream of the pi gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at -8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (-3 kb), still belongs to the domain of the alpha-globin genes.
authors.affiliation: Institute of Biology of the Gene, Russian Academy of Sciences, Moscow.
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
authors.forename: C V
authors.initials: CV
authors.lastname: De Moura Gallo
authors.forename: K
authors.initials: K
authors.lastname: Scherrer
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000235:genetics; D002645:Chickens / Q000235:genetics*; D002843:Chromatin; D002874:Chromosome Mapping; D003850:Deoxyribonuclease I; D005914:Globins / Q000235:genetics*; D005810:Multigene Family
chemical_list: D002843:Chromatin; D005914:Globins; D003850:Deoxyribonuclease I