Telomeric DNA binding proteins.
The physical ends of eukaryotic chromosomes form a specialized nucleoprotein complex composed of DNA and DNA binding proteins. This nucleoprotein complex, termed the telomere, is essential for chromosome stability. In most organisms, the DNA portion of the nucleo-protein complex consists of simple tandem DNA repeats with one strand guanine rich. The protein portion of the complex is less well understood. The experiments presented in two recent papers represent different stages in the characterization of the telomeric DNA binding proteins. The first paper presents a structure-function study of the Oxytricha telomeric DNA binding proteins and the second paper shows the identification and initial characterization of a telomeric DNA binding activity from Xenopus laevis. These two reports provided valuable information in understanding the structure and function of telomeres.
Lin
J J
JJ
Fred Hutchinson Cancer Research Center, Seattle, WA 98105.
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000378:metabolism*; D016054:DNA, Protozoan / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D016813:Oxytricha / Q000378:metabolism; D015800:Protozoan Proteins / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D016615:Telomere / Q000378:metabolism*; D014981:Xenopus / Q000235:genetics / Q000378:metabolism
D016054:DNA, Protozoan; D004268:DNA-Binding Proteins; D015800:Protozoan Proteins; D011994:Recombinant Proteins; D004247:DNA