Seven consecutive days of exercise lowers plasma insulin responses to an oral glucose challenge in sedentary elderly.
OBJECTIVE
To assess the effects of 1 and 7 consecutive days of exercise on glucose and insulin responses to an oral glucose challenge.


METHODS
Intervention group assessed at baseline and after 1 and 7 days of exercise.


METHODS
Academic medical institution.


METHODS
Nine healthy 60 to 80-year-old men and women.


METHODS
Seven days of 50 minutes of exercise at 70% VO2 max.


METHODS
Body weight, body composition, and glucose and insulin levels and responses to an oral glucose challenge at baseline and after 1 and 7 days of exercise.


RESULTS
Fasting plasma insulin levels and plasma insulin responses to an oral glucose challenge were reduced by 15% and 20%, respectively, with 7 consecutive days of exercise that resulted in no change in body weight or body composition. No changes in glucose or insulin levels or responses to the oral glucose challenge were evident after a single day of exercise.


CONCLUSIONS
The hyperinsulinemia associated with aging can be blunted significantly by repeated bouts of exercise in the elderly, independent of any changes in body composition.
Cononie
C C
CC
Division of Geriatric Medicine, Francis Scott Key Medical Center, Baltimore, Maryland.
Goldberg
A P
AP
Rogus
E
E
Hagberg
J M
JM
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D001786:Blood Glucose / Q000502:physiology*; D001823:Body Composition; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000517:prevention & control*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol