Successful pregnancies with unstimulated cycle oocyte donation using an antagonist of gonadotropin-releasing hormone.
We achieved two ongoing pregnancies in five older recipients with natural cycle oocyte donation from five young donors using a GnRH antagonist, with hMG and hCG to complete oocyte maturation. This provides a new alternative to ovarian stimulation for both oocyte donation and routine IVF.
Meldrum
D R
DR
Center for Advanced Reproductive Care, Redondo, California 90277.
Rivier
J
J
Garzo
G
G
Wisot
A
A
Stubbs
C
C
Hamilton
F
F
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors*; D009865:Oocytes; D011247:Pregnancy; D013048:Specimen Handling / Q000379:methods*; D014019:Tissue Donors
C057805:LHRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Pal(3)-Arg(5)-Glu(6)-AlaNH2(10)-; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone