title: Distinction between focally accelerated bone formation and osteomalacia in carcinoma of prostate metastasised to bone.
abstract: We studied the histological indices of skeletal turnover in 40 patients with carcinoma of the prostate and skeletal metastases in order to determine the prevalence of osteomalacia. In 20 patients biopsied through uninvolved bone, the histological indices of bone turnover were normal. In particular, osteoid seam width and bone formation rates were consistently normal, indicating the absence of osteomalacia. In biopsies from tumour-laden bone, hyperosteoidosis was present, usually associated with increased amounts of woven collagen and consistently associated with high rates of bone formation and mineralisation. It was concluded that hyperosteoidosis in prostatic cancer is rarely due to osteomalacia.
authors.affiliation: WHO Collaborating Centre for Metabolic Bone Diseases, Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Taube
authors.forename: M N
authors.initials: MN
authors.lastname: Beneton
authors.forename: J L
authors.initials: JL
authors.lastname: Williams
authors.forename: E V
authors.initials: EV
authors.lastname: McCloskey
authors.forename: J A
authors.initials: JA
authors.lastname: Kanis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000150:complications* / Q000378:metabolism / Q000556:secondary*; D001862:Bone Resorption / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000737:chemistry; D003937:Diagnosis, Differential; D006801:Humans; D015576:Hyperostosis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*