[The change in dynamics of cell proliferation cycle by passive smoking in fetal rabbit].
An animal model of IUGR was induced in rabbit by passive smoking. The dynamics of cell proliferation cycle in fetal brain, liver and placenta was analysed by flow cytometry. The results showed that the ratio of cell number in phase G0+G1 to the total number of cells in all phases was increased, while the cell number in phase S+G2M to the total cell number of all phases was decreased. It means that the proliferation of fetal cell and placenta was inhibited significantly. The actual inhibition was occurred in the phase of transformation from phase G1 to S.
Zhang
X Q
XQ
Renji Hospital, Shanghai Second Medical University.
D000818:Animals; D001921:Brain / Q000473:pathology*; D002453:Cell Cycle; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000473:pathology*; D005434:Flow Cytometry; D008099:Liver / Q000473:pathology*; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011817:Rabbits; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D014028:Tobacco Smoke Pollution