title: Erythrocyte sodium cannot predict hypotensive effects of calcium channel blockers.
abstract: Antihypertensive efficacy of the calcium channel blocker, nilvadipine, was investigated in 21 patients with essential hypertension in relation to the intracellular sodium concentration ([Na]i) in erythrocytes and clinical variables, such as age, body weight, pretreatment blood pressure and plasma renin activity. Dihydropyridine nilvadipine reduced mean blood pressure from 120 +/- 6 to 106 +/- 8 mmHg (p < 0.01). The hypotensive effect of nilvadipine was positively correlated with age (r = 0.67, p < 0.01) and inversely correlated with plasma renin activity (r = -0.62, p < 0.01), but was not correlated with erythrocyte [Na]i or any other indices. Erythrocyte [Na]i was decreased with nilvadipine treatment (8.27 +/- 1.69 to 7.97 +/- 1.49 mM, p < 0.01). However, no link was found between the change in [Na]i and the hypotensive effect of the drug. In conclusion, the antihypertensive efficacy of nilvadipine was predictable by age and renin status, but not by erythrocyte [Na]i. A significant role of reduction of [Na]i in the hypotensive effect of the calcium channel blockers was not detected.
authors.affiliation: Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oshima
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: R
authors.initials: R
authors.lastname: Ozono
authors.forename: M
authors.initials: M
authors.lastname: Ishida-Kainouchi
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Ishibashi
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Okura
authors.forename: M
authors.initials: M
authors.lastname: Kanbe
authors.forename: G
authors.initials: G
authors.lastname: Kajiyama
mesh_terms: D000367:Age Factors; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; C035100:nilvadipine; D012964:Sodium; D012083:Renin; D009543:Nifedipine