title: Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women.
abstract: OBJECTIVE
  To determine whether weight loss in obese, hyperandrogenic, anovulatory women is associated with resumption of ovulation and/or with changes in insulin, androgen, and gonadotropin concentrations.
  
  
  METHODS
  Prospective, randomized, controlled study.
  
  
  METHODS
  University research center.
  
  
  METHODS
  Twelve obese, hyperandrogenic, anovulatory women.
  
  
  METHODS
  Twelve-week weight loss program in treatment (n = 6); 12-week "waiting list" in control group (n = 6).
  
  
  METHODS
  [1] Ovulation; [2] fasting insulin and glucose measurements; [3] sex hormone-binding globulin (SHBG), total and non-SHBG T concentrations; [4] LH pulse frequency, amplitude, and concentration; and [5] FSH concentration.
  
  
  RESULTS
  In contrast with the control group who showed no change in weight, ovulation status, or hormone levels, women in the treatment group lost an average of 16.2 kg and showed a significant increase in SHBG, a significant decline in non-SHBG T, and a decline (though nonsignificant) in fasting insulin. Four of six subjects resumed ovulation. However, no changes were evident in LH pulse frequency or amplitude or in mean LH and FSH concentrations.
  
  
  CONCLUSIONS
  Weight loss in obese, hyperandrogenic, anovulatory women appears to reduce insulin and non-SHBG T concentrations despite the absence of a change in gonadotropin secretion and may lead to resumption of ovulation.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: D S
authors.initials: DS
authors.lastname: Guzick
authors.forename: R
authors.initials: R
authors.lastname: Wing
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: S L
authors.initials: SL
authors.lastname: Berga
authors.forename: S J
authors.initials: SJ
authors.lastname: Winters
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D000858:Anovulation; D001786:Blood Glucose / Q000378:metabolism; D004038:Diet, Reducing; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D015431:Weight Loss
chemical_list: D000728:Androgens; D001786:Blood Glucose; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone