title: Clinical and pharmacokinetic observations on valproate: a 3 year follow-up study in 100 children with generalized epilepsy.
abstract: The results of a 36 month observation of therapeutic effects of various schemes of long-term monitored treatment of primary generalized epilepsy with Valproate (VPA) derivatives is presented. A hundred children and adolescents aged 5-15 constituted the experimental group. In each of 3 groups the drug was administered in individually assessed doses. An optimal antiepileptic clinical effect of VPA was achieved thanks to therapeutic monitoring, especially pharmacokinetic studies.
authors.affiliation: Department of Developmental Neurology, University of Medical Sciences, Poznań, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Steinborn
authors.forename: B
authors.initials: B
authors.lastname: Galas-Zgorzalewicz
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004829:Epilepsy, Generalized / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D014635:Valproic Acid / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid