title: In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species.
abstract: Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.
authors.affiliation: Institut für Pharmazeutische Biologie der Universität München, Federal Republic of Germany.
authors.forename: B
authors.initials: B
authors.lastname: Müller-Jakic
authors.forename: W
authors.initials: W
authors.lastname: Breu
authors.forename: A
authors.initials: A
authors.lastname: Pröbstle
authors.forename: K
authors.initials: K
authors.lastname: Redl
authors.forename: H
authors.initials: H
authors.lastname: Greger
authors.forename: R
authors.initials: R
authors.lastname: Bauer
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D012756:Sheep; D013552:Swine
chemical_list: D000577:Amides; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors