title: Healing pattern of bone regeneration in membrane-protected defects: a histologic study in the canine mandible.
abstract: In this study, standard and prototype reinforced e-PTFE membranes were used to evaluate the pattern of bone regeneration in membrane-protected defects in the mandibles of four dogs. Following a healing period of 2 and 4 months, control sites without membranes exhibited incomplete osseous healing with a persisting defect. Test sites with membranes demonstrated significantly better bone healing, although bone regeneration was not yet completed at 4 months. The histologic evaluation showed that bone regeneration, once activated, progresses in a programmed sequence through a series of maturation steps, which closely resemble the pattern of bone development and growth.
authors.affiliation: Institute of Pathophysiology, University of Berne, Switzerland.
authors.forename: R K
authors.initials: RK
authors.lastname: Schenk
authors.forename: D
authors.initials: D
authors.lastname: Buser
authors.forename: W R
authors.initials: WR
authors.lastname: Hardwick
authors.forename: C
authors.initials: C
authors.lastname: Dahlin
mesh_terms: D000539:Alveolar Process / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D008297:Male; D008334:Mandible / Q000473:pathology* / Q000503:physiopathology; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D014945:Wound Healing
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene