Interleukin 6-producing malignant mesothelioma.
Systemic amyloidosis of the amyloid A (AA) type, is occasionally associated with various neoplasms, but the cause is still unclear. We obtained interleukin 6 (IL-6)-producing cells designated YO from a primary culture of a malignant peritoneal mesothelioma of epithelial type obtained from a 62-year-old woman. Post mortem examination revealed that the patient had systemic amyloidosis of the AA type. The supernatant media of YO cells, as well as recombinant human IL-6, successfully induced nonneoplastic liver cells to produce serum AA (SAA). Our data suggest that IL-6 produced by the tumor cells may have played an important role in the paraneoplastic syndrome of AA amyloidosis in this patient.
Motoyama
T
T
Department of Pathology, Niigata University School of Medicine, Japan.
Honma
T
T
Watanabe
H
H
Honma
S
S
Kumanishi
T
T
Abe
S
S
D000686:Amyloidosis / Q000209:etiology*; D015152:Blotting, Northern; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000096:biosynthesis*; D008654:Mesothelioma / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000032:analysis; D014407:Tumor Cells, Cultured
D015850:Interleukin-6; D000685:Serum Amyloid A Protein