Soil decreases the dermal penetration of phenol in male pig in vitro.
Skin is a primary route of exposure to phenol, a major chemical found in hazardous waste sites. The effect of soil adsorption on the dermal bioavailability of phenol was assessed by applying [14C]phenol alone (P) or with sandy (P-S) or clay (P-C) soil to dermatomed male pig skin samples in flow-through diffusion cells. Maximum penetration of P-S and P-C was significantly decreased by one-half and by two-thirds, respectively, compared to P. Furthermore, the penetration of phenol into receptor fluid and the amount bound to skin were significantly lower when phenol was adsorbed to either soil versus P. While less radioactivity penetrated skin with soil-adsorbed phenol treatment than P, significantly more radioactivity was loosely adsorbed to skin and could be easily washed off of the skin surface by soap and water. Only a small fraction (< 5%) of the chemical was metabolized by skin to hydroquinone and catechol in all treatment groups. The results of this study indicate that the bioavailability and thus the potential health risk from dermal exposure to phenol is reduced if the chemical is adsorbed to soil.
Skowronski
G A
GA
Pharmacology and Toxicology Department, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103-2714.
Kadry
A M
AM
Turkall
R M
RM
Botrous
M F
MF
Abdel-Rahman
M S
MS
D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D008297:Male; D019800:Phenol; D010636:Phenols / Q000378:metabolism / Q000493:pharmacokinetics*; D012869:Skin Absorption; D012987:Soil; D013552:Swine; D013997:Time Factors
D010636:Phenols; D012987:Soil; D019800:Phenol