Effects of kami-kihi-to (jia-wei-gui-pi-tang) on autoantibodies in patients with chronic immune thrombocytopenic purpura.
We studied the effect of Kami-kihi-to (Jia-Wei-Gui-Pi-Tang) on the production of autoantibodies in ten patients with chronic immune thrombocytopenic purpura. After administration of Kami-kihi-to, platelet count was increased in seven of the ten patients (p < 0.05). Using Western blotting, we demonstrated the disappearance of autoantibody reaction with antigen in one patient. However, platelet-associated IgG was decreased in eight of ten patients (p < 0.05). Kami-kihi-to appears to promote the suppression of autoantibodies in patients with chronic immune thrombocytopenic purpura. No side effects were observed in any patient. Thus, Kami-kihi-to may be a useful and safe drug in the management of chronic immune thrombocytopenia purpura.
Yamaguchi
K
K
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Kido
H
H
Kawakatsu
T
T
Fukuroi
T
T
Suzuki
M
M
Yanabu
M
M
Nomura
S
S
Kokawa
T
T
Yasunaga
K
K
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D015153:Blotting, Western; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology* / Q000628:therapy
D001323:Autoantibodies; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; C073747:kamikihi-to