Effects of a fish oil rich diet on hyperoxic lung damage in mice.
Mice were fed a chow diet plus 10% cellulose, 10% fish oil or 10% sunflower oil for 3 weeks, then exposed to 100% oxygen for 75 h. Large changes in lung fatty acid composition occurred, but this did not affect hyperoxic lung damage nor levels of thiobarbituric acid reactive substances or myeloperoxidase in lungs of mice following exposure to hyperoxia. Thus there is no evidence that the ingestion of large quantities of fish oil increased the susceptibility to the oxidative stress induced by hyperoxia.
Jamieson
D
D
School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia.
Lin
Y
Y
Gibson
R
R
D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects*; D005395:Fish Oils / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D055370:Lung Injury; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000633:toxicity*; D009195:Peroxidase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D017392:Thiobarbituric Acid Reactive Substances; D009195:Peroxidase; D010100:Oxygen