title: [Transport of 2,5-dimethoxy-4-methylamphetamine by macroheterocycles across erythrocyte membranes].
abstract: Transport of 2,5-dimethoxy-4-methylamphetamine across human erythrocytes by the 18-crown-6, monoaza-15-crown-5 and diaza-18-crown-6 is studied and evaluated spectrophotometrically. It is shown that crown-ethers at low concentration (1-2 mM) protect erythrocytes against their natural homolysis. 2,5-dimethoxy-4-methylamphetamine provides 2-5% hemolysis of erythrocytes. In the presence of macrocycles (5 mM) hemolysis of erythrocytes increases from 6.5 to 30%. A hemolytic effect of 2,5-dimethoxy-4-methylamphetamine depends on the structure of the crown ethers and, apparently, confirms significant role of complexes of the crown-ethers with amine in these processes.
authors.forename: T L
authors.initials: TL
authors.lastname: Karaseva
authors.forename: A S
authors.initials: AS
authors.lastname: Iavorskiĭ
authors.forename: V I
authors.initials: VI
authors.lastname: Pavlovskiĭ
authors.forename: Zh N
authors.initials: ZhN
authors.lastname: Tsapenko
mesh_terms: D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000493:pharmacokinetics*; D001692:Biological Transport / Q000502:physiology; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000378:metabolism*; D006801:Humans
chemical_list: D006571:Heterocyclic Compounds; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine
vernacular_title: Transport 2,5-dimetoksi-4-metilamfetamina makrogeterotsiklami cherez membrany éritrotsitov.