The primary structure of pancreatic ribonuclease from mole rat superspecies Spalax leucodon.
The primary structure of pancreatic ribonuclease of the superspecies Spalax leucodon has been determined. Only one difference with the previously determined sequence of the superspecies Spalax ehrenbergi was detected; the proline residue at position 42 has been replaced by alanine. Proline-42 is a well-conserved residue in mammalian pancreatic ribonucleases; the only other species with alanine at this position is the three-toed sloth. As the Muridae and the Spalacidae diverged 20-40 million years ago and the superspecies S. leucodon and S. ehrenbergi about 1-2 million years ago, and as pancreatic ribonuclease exhibits 24 substitutions in the line from the Muridae/Spalacidae ancestor to Spalax, a difference of one amino residue between the sequences of the two Spalax superspecies is what may be expected.
Zhao
W
W
Biochemisch Laboratorium, Rijksuniversiteit Groningen, The Netherlands.
Beintema
J J
JJ
Hofsteenge
J
J
Nevo
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E
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D017124:Conserved Sequence; D014644:Genetic Variation; D008322:Mammals / Q000235:genetics; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics; D010179:Pancreas / Q000201:enzymology*; D012260:Ribonucleases / Q000737:chemistry / Q000235:genetics*; D012377:Rodentia / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014421:Turkey
D012260:Ribonucleases