title: Abnormal pattern of cerebral glucose metabolic rates involving language areas in young adults with Down syndrome.
abstract: Correlational and discriminant analyses were applied to "resting" state (eyes covered, ears plugged) regional cerebral glucose metabolic data, obtained with positron emission tomography (PET) and [18F] fluorodeoxyglucose in 14 retarded adults with Down syndrome (10 men, 4 women; age 26-38 years) and 17 age- and sex-matched controls. Down and control subjects showed no differences in the pattern of correlations. However, a discriminant function, reflecting regional interactions involving primary language areas, successfully classified the Down (100%) and control (88%) subjects. The results are consistent with a disruption of brain regional interactions involving language areas in adults with Down syndrome.
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging, Bethesda, Maryland 20892.
authors.forename: N P
authors.initials: NP
authors.lastname: Azari
authors.forename: B
authors.initials: B
authors.lastname: Horwitz
authors.forename: K D
authors.initials: KD
authors.lastname: Pettigrew
authors.forename: C L
authors.initials: CL
authors.lastname: Grady
authors.forename: J V
authors.initials: JV
authors.lastname: Haxby
authors.forename: K R
authors.initials: KR
authors.lastname: Giacometti
authors.forename: M B
authors.initials: MB
authors.lastname: Schapiro
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D004314:Down Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007361:Intelligence Tests; D007805:Language Development Disorders / Q000175:diagnosis; D007807:Language Tests; D008297:Male; D009483:Neuropsychological Tests; D012044:Regression Analysis; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose