title: Hepatic vagotomy effects on metabolic challenges during parenteral nutrition in rats.
abstract: During parenteral nutrition (PN) glucoprivic-induced feeding appeared to be neutralized by the oxidation of infused fatty acids. With the use of a latin-square design, the feeding response to 2-deoxy-D-glucose (2-DG) and/or 2-mercaptoacetate (MA) was evaluated in male Sprague-Dawley rats with hepatic branch vagotomy (HV) or sham operations (SO). Rats received continuous infusions of 0.9% saline or PN providing 100% of daily caloric needs (PN-100) for four consecutive days. During PN-100, food intake was stimulated by 2-DG in HV rats and when fatty acid oxidation was simultaneously inhibited by MA. 2-DG-induced hyperglycemia was apparent under all conditions. Lipoprivic-induced feeding and increased plasma free fatty acid concentrations were absent in HV rats, whether MA was administered alone or with 2-DG. The feeding response to glucoprivic challenges is influenced by the relative availability of alternate energy sources. The lack of feeding response to 2-DG during PN-100 is mediated by vagal input of hepatic fatty acid oxidation status.
authors.affiliation: Department of Surgery, State University of New York Health Science Center, University Hospital, Syracuse 13210.
authors.forename: J L
authors.initials: JL
authors.lastname: Beverly
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Yang
authors.forename: M M
authors.initials: MM
authors.lastname: Meguid
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D002149:Energy Intake; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000294:innervation*; D008297:Male; D010288:Parenteral Nutrition; D051381:Rats; D017207:Rats, Sprague-Dawley; D013864:Thioglycolates / Q000494:pharmacology; D014628:Vagotomy
chemical_list: D005230:Fatty Acids, Nonesterified; D013864:Thioglycolates; C017487:2-mercaptoacetate; D003847:Deoxyglucose