[Oxygen free radical injury after delayed fluid resuscitation in burn patients].
Sixty seven burn patients (TBSA > 30%) were entered in a prospective study. Among them, twenty seven experienced delayed fluid resuscitation (DFR group) and the rest had early resuscitation (non-DFR group). Oxygen free radical (OFR) content in the blood was measured with ESR technic, and levels of blood SOD, blood GSHpx, serum MDA were also determined. The results showed: 1 The morbidity and mortality of burn shock and MSOF were higher in DFR group as compared with non-DFR group. 2 There was a significant increase of blood OFR content subsequent to resuscitation in DFR group as compared with that in non-DFR group. 3 The level of MDA in the serum of patients with burn shock was higher in DFR group than that in non-DFR group. 4 In DFR group, the level of serum MDA is higher in patients who developed MSOF as compared with that in patients who did not develop MSOF. The data indicated that DFR augmented the morbidity and mortality of burn shock and MSOF, in which OFR might play a role.
Yang
H M
HM
Burn Unit, Postgraduate Medical College.
D000293:Adolescent; D000328:Adult; D002056:Burns / Q000097:blood*; D005260:Female; D005440:Fluid Therapy; D005609:Free Radicals; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology; D011446:Prospective Studies; D012774:Shock, Traumatic / Q000097:blood* / Q000628:therapy; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
D005609:Free Radicals; D008315:Malondialdehyde; D013482:Superoxide Dismutase