title: Effects of polyaspartic acid on pharmacokinetics of tobramycin in two strains of rat.
abstract: To provide insight into polyaspartic acid nephroprotection and differences in aminoglycoside renal toxicity between two rat strains, the single-dose pharmacokinetics of tobramycin was examined in the presence and absence of polyaspartic acid. Following a single subcutaneous 6.5-mg/kg dose of tobramycin alone, higher aminoglycoside concentrations were measured in Sprague-Dawley rats than in Fischer rats (P < 0.05). Simultaneous administration of polyaspartic acid (50 mg/kg) and tobramycin did not alter the concentrations of tobramycin in serum. The amount of tobramycin in renal tissue and the amount recovered in urine over a 24-h period were greater in both rat strains when tobramycin and polyaspartic acid were given concomitantly. In summary, polyaspartic acid did not alter the concentrations in serum achieved after a single dose of tobramycin in two different rat strains but did result in higher renal concentrations and greater urinary excretion of tobramycin.
authors.affiliation: Fujisawa Pharmaceutical Co., Deerfield, Illinois 60015.
authors.forename: M K
authors.initials: MK
authors.lastname: Reinhard
authors.forename: I
authors.initials: I
authors.lastname: Bekersky
authors.forename: T W
authors.initials: TW
authors.lastname: Sanders
authors.forename: B J
authors.initials: BJ
authors.lastname: Harris
authors.forename: G H
authors.initials: GH
authors.lastname: Hottendorf
mesh_terms: D000818:Animals; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D010455:Peptides / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D014031:Tobramycin / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D010455:Peptides; C017645:polyaspartate; D014031:Tobramycin