[The effect of the physical status of the neutrophil membranes on their functional metabolic activity in hypertension patients].
In 76 untreated patients with Stages I-II hypertensive disease, spectrophotometry with lipid specific pyrene fluorescence probe revealed higher microviscosity in the lipid phase of neutrophilic membranes, which was induced by elevated levels of cholesterol and enhanced activation of lipid peroxidation. This resulted in increased functional and metabolic neutrophilic activity which was determined by luminol-dependent zimozan-induced chemiluminescence of whole venous blood. The correlation coefficient between the microviscosity of membranes and the chemiluminescence of neutrophils is 0.82 (p).
Malishevskiĭ
M V
MV
Zhmurov
V A
VA
Gapon
L I
LI
Kashuba
E A
EA
Argunova
G A
GA
D000328:Adult; D001809:Blood Viscosity; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008297:Male; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D008563:Membrane Lipids
Vliianie fizicheskogo sostoianiia membran neĭtrofilov na ikh funktsional'no-metabolicheskuiu aktivnost' u bol'nykh gipertonicheskoĭ bolezn'iu.