title: Blood glucose and insulin response to intravenous glucose by patients with chronic Chagas' disease and alcoholism.
abstract: Blood glucose and insulin responses to intravenous glucose 500 mg/kg in a group of alcoholic chagasic patients (Group I, N = 15) were assessed and compared to those of a group of patients with Chagas' disease without alcoholism (Group II, N = 16), a group of alcoholics without Chagas' disease (Group III, N = 22), and a group of non-alcoholics without Chagas' disease (Group IV, N = 15). Determinations of serum glucose and insulin were done under fasting conditions, 5 and 10 min after the injection of 50% glucose. There was no difference in mean serum glucose levels between groups. Mean serum insulin levels at times 5 and 10 min and for the total integrated response were lower (P < 0.05) in Groups I and II as compared to Group IV; at time 10 min the mean was lower (P < 0.05) in Group III as compared to Group IV. There was a nonsignificant trend for a lower insulinemic response in Group I as compared to Group II. These data suggest denervation of or injury to pancreatic B cell by Chagas' disease.
authors.affiliation: Departamento de Clínica Médica, Universidade Federal de Uberlândia, MG, Brasil.
authors.forename: L C
authors.initials: LC
authors.lastname: Oliveira
authors.forename: Y
authors.initials: Y
authors.lastname: Juliano
authors.forename: N F
authors.initials: NF
authors.lastname: Novo
authors.forename: M M
authors.initials: MM
authors.lastname: Neves
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D014355:Chagas Disease / Q000097:blood*; D002908:Chronic Disease; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D008297:Male; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose