Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: probable effects of family history of schizophrenia?
Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).
Nimgaonkar
V L
VL
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pennsylvania.
Zhang
X R
XR
Caldwell
J G
JG
Ganguli
R
R
Chakravarti
A
A
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011336:Probability; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3