Monosomy 7, diabetes insipidus and acute myeloid leukemia in childhood.
The triad of diabetes insipidus (DI), monosomy 7, and acute myeloid leukemia in a 7-year-old boy is described. This triad has been described in adults but not in children. The DI ran a transient, self-limiting course and required no specific therapy. The pathogenesis of DI remains unknown, and its transient nature may result in this component of the triad going unnoticed.
Kanabar
D J
DJ
Department of Paediatric Oncology, St Bartholomew's Hospital, London, England.
Betts
D R
DR
Gibbons
B
B
Kingston
J E
JE
Eden
O B
OB
D000208:Acute Disease; D002648:Child; D002897:Chromosomes, Human, Pair 7; D003919:Diabetes Insipidus / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D009006:Monosomy