title: Actions of acromelic acid on nervous system L-glutamate receptors.
abstract: Acromelic acid, a naturally occurring kainoid, isolated from the mushroom Clitocybe acromelalga, is a weak displacer of [3H]L-glutamate binding to cockroach (Periplaneta americana) nerve cord membranes. Acromelic acid (1 mM) displaces approximately 60% of specifically bound [3H]L-glutamate. When applied by bath perfusion to the cell body membrane of the cockroach fast coxal depressor motor neurone, acromelic acid generated slow, prolonged, dose-dependent depolarizations at concentrations of 0.3 microM and above. Thus acromelic acid is among the most potent of the excitatory amino acids tested to date on insect neurones.
authors.affiliation: Department of Zoology, University of Cambridge, United Kongdom.
authors.forename: D B
authors.initials: DB
authors.lastname: Sattelle
authors.forename: M I
authors.initials: MI
authors.lastname: Sepúlveda
authors.forename: H
authors.initials: H
authors.lastname: Shinozaki
authors.forename: M
authors.initials: M
authors.lastname: Ishida
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects; D010526:Periplaneta; D011869:Radioligand Assay; D017470:Receptors, Glutamate / Q000187:drug effects*
chemical_list: D017470:Receptors, Glutamate; C051743:acromelic acid A; D007608:Kainic Acid