title: Crystal and molecular structures of pyridazinone cardiovascular agents.
abstract: The crystal and molecular structures of 11 6-substituted pyridazinone derivatives: 6-phenyl-3(2H)-pyridazinone-acetic acid (1/1) (1), 6-(4-aminophenyl)- 3(2H)-pyridazinone (2), 6-(4-aminophenyl)- 5-methyl-3(2H)-pyridazinone (3), 6-(4-acetamidophenyl)- 3(2H)-pyridazinone (4), 6-(4-acetamido-2- methoxyphenyl)-3(2H)-pyridazinone (5), 6-(2-aminophenyl)-3(2H)- pyridazinone (6), 6-phenyl-3(2H)- pyrazinone (7), 6-(4-aminophenyl)-4,5-dihydro- 3(2H)-pyridazinone (8), (R)-(-)-6[4-(3-bromopropionamido)phenyl]- 4,5-dihydro-5-methyl-3(2H)-pyridazinone (9), (R)-(-)-6-(4-ammoniophenyl)-4,5- dihydro-5-methyl-3(2H)-pyridazinone (-)-tartrate-dichloromethane-methanol (1/1/1) (10), 4,5-dihydro-6-methyl-3(2H)-pyridazinone (11) have been determined as part of a study to determine the relationship between their cardiovascular properties and molecular structure and dimensions. For the two optically resolved chiral derivatives (9) and (10) the absolute configuration has been determined.
authors.affiliation: Chemical Crystallography Laboratory, Oxford University, England.
authors.forename: K
authors.initials: K
authors.lastname: Prout
authors.forename: C
authors.initials: C
authors.lastname: Bannister
authors.forename: K
authors.initials: K
authors.lastname: Burns
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: B H
authors.initials: BH
authors.lastname: Warrington
authors.forename: J G
authors.initials: JG
authors.lastname: Vinter
mesh_terms: D002317:Cardiovascular Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D011724:Pyridazines / Q000737:chemistry*
chemical_list: D002317:Cardiovascular Agents; D011724:Pyridazines