title: Comparative mapping of SRY in the great apes.
abstract: Cytogenetic studies of the primate Y chromosomes have suggested that extensive rearrangements have occurred during evolution of the great apes. We have used in situ hybridization to define these rearrangements at the molecular level. pHU-14, a probe including sequences from the sex determining gene SRY, hybridizes close to the early replicating pseudoautosomal segment in a telomeric or subtelomeric position of the Y chromosomes of all great apes. The low copy repeat detected by the probe Fr35-II is obviously included in Y chromosomal rearrangements during hominid evolution. These results, combined with previous studies, suggest that the Y chromosome in great apes has a conserved region including the pseudoautosomal region and the testis-determining region. The rest of the Y chromosome has undergone several rearrangements in the different great apes.
authors.affiliation: Institut für Humangenetik und Anthropologie, Universität Freiburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Toder
authors.forename: S
authors.initials: S
authors.lastname: Zeitler
authors.forename: P N
authors.initials: PN
authors.lastname: Goodfellow
authors.forename: W
authors.initials: W
authors.lastname: Schempp
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D006071:Gorilla gorilla / Q000235:genetics*; D015186:Hominidae / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D009687:Nuclear Proteins; D002679:Pan troglodytes / Q000235:genetics*; D011148:Pongo pygmaeus / Q000235:genetics*; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors / Q000235:genetics; D014998:Y Chromosome
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors