title: The health status of women following cosmetic surgery.
abstract: A retrospective study was performed to determine the frequency of new symptoms and diseases after silicone breast implantation. Questionnaires were mailed to 826 women who made up a breast implant group (n = 516) and a control group who had undergone blepharoplasty (n = 124), liposuction (n = 111), or rhinoplasty (n = 75). Responses were obtained from 370 women (45 percent); however, 68 of these patients (18 percent) were considered ineligible. The overall response rate was 59 percent for the breast implant group and 46 percent for controls. The 302 eligible women included patients with silicone breast implants (n = 222) and controls (n = 80). Women with implants were significantly younger than controls, the median age of women with breast implants being 37 years compared with 46.5 years for controls (p < 0.0001). We compared the incidence of 23 symptoms and 4 connective-tissue diseases after cosmetic surgery in the two groups. The symptoms of swollen glands under arms (p < 0.05) and tender glands under arms (p < 0.01) were statistically more frequent in the breast implant group. The symptom change in skin color was more common in the controls (p < 0.001). The Bonferroni correction for multiple (27) endpoints adjusts the 5 and 1 percent significance cutoff points to 0.00185 and 0.00037, respectively, leaving only change of skin color significant at the 5 percent level on the adjusted data. No cases of scleroderma or lupus were found, and the incidence of arthritis was not significantly different between the implant and control groups.
authors.affiliation: Department of Surgery, University of South Florida College of Medicine, Tampa.
authors.forename: K E
authors.initials: KE
authors.lastname: Wells
authors.forename: C W
authors.initials: CW
authors.lastname: Cruse
authors.forename: J L
authors.initials: JL
authors.lastname: Baker
authors.forename: S M
authors.initials: SM
authors.lastname: Daniels
authors.forename: R A
authors.initials: RA
authors.lastname: Stern
authors.forename: C
authors.initials: C
authors.lastname: Newman
authors.forename: M J
authors.initials: MJ
authors.lastname: Seleznick
authors.forename: F B
authors.initials: FB
authors.lastname: Vasey
authors.forename: S
authors.initials: S
authors.lastname: Brozena
authors.forename: S E
authors.initials: SE
authors.lastname: Albers
mesh_terms: D000328:Adult; D003240:Connective Tissue Diseases / Q000209:etiology; D005143:Eyelids / Q000601:surgery; D005260:Female; D006801:Humans; D015187:Lipectomy; D016462:Mammaplasty / Q000009:adverse effects; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D019736:Prostheses and Implants; D012189:Retrospective Studies; D012225:Rhinoplasty; D012828:Silicones; D013518:Surgery, Plastic / Q000009:adverse effects; D011795:Surveys and Questionnaires; D016387:Women's Health
chemical_list: D012828:Silicones