A novel variant of the human blood group K1 antigen.
A discrepancy in duplicate anti-K1 typing in a parentage case led to the discovery of an unusual K1 blood group antigen. Red blood cells from the propositus (JC) express a rare variant of the K1 antigen that is detectable by only 8 of 72 sera containing anti-K1. Absorption and elution studies using reactive anti-K1 confirmed the presence of a K1 antigen. Nonreactive anti-K1 was not absorbed by or eluted from JC's red blood cells. Red cells from 3 of the propositus's siblings also had the variant K1 antigen. The variant antigen exhibited qualitative as well as quantitative differences as compared to normal K1, and we have named it K1var.
Skradski
K
K
Memorial Blood Center of Minneapolis, Minn.
Reid
M E
ME
Mount
M
M
Polesky
H F
HF
Sausais
L
L
Yacob
M
M
Batts
R
R
D000328:Adult; D003298:Coombs Test; D005819:Genetic Markers; D014644:Genetic Variation; D006386:Hemagglutination Tests; D006801:Humans; D007626:Kell Blood-Group System / Q000235:genetics*; D008297:Male; D010334:Paternity
D005819:Genetic Markers; D007626:Kell Blood-Group System