[Biochemical and toxicological studies of fenvalerate on the lung].
Toxicological effects of fenvalerate on rat lungs by bronchoalveolar lavage (BAL) and biochemical changes in 20 workers exposed to fenvalerate were studied. The results showed that the levels of CPK, albumin, TP, AKP, ACP, alpha 1-AT, MDH, LDH, glucose, and lactic acid in BAL fluid increased significantly, with a CPK level the most sensitive one. most of the above parameters in BAL fluid changed four hours after exposure and returned basically to normal on the fourth day after exposure. Only the levels of ACP, alpha 1-AT and albumin were found increased in their blood. It showed a good linear relationship between blood and BAL levels of alpha 1-AT and ACP. Changes in some biochemical parameters were also found in workers exposed to fenvalerate, which correlated to the length of their employment. The results suggested inhalation of fenvalerate may cause alveolitis, pulmonary edema, and damage to lung cells.
Tian
H L
HL
Department of Public Health, Suzhou Medical College.
D000418:Albumins / Q000378:metabolism; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008171:Lung Diseases / Q000139:chemically induced; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000418:Albumins; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D003402:Creatine Kinase; C017690:fenvalerate