title: Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation.
abstract: Our results confirm the previous report that rapid suppression by GnRH-a is favorable relative to delayed suppression (1). They further indicate that the pattern of E2 production during GnRH-a-induced ovarian suppression may be predictive of cycle outcome. We suggest that imperfect pituitary suppression of bioactive LH as indicated by an aberrant rise in E2 during GnRH-a down-regulation may compromise oocyte quality and ultimately impair implantation. Further study of follicular phase E2 response to GnRH-a suppression may provide a prognostic marker for implantation.
authors.affiliation: Department of Obstetrics and Gynecology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111.
authors.forename: A S
authors.initials: AS
authors.lastname: Penzias
authors.forename: G
authors.initials: G
authors.lastname: Lee
authors.forename: D B
authors.initials: DB
authors.lastname: Seifer
authors.forename: F N
authors.initials: FN
authors.lastname: Shamma
authors.forename: A H
authors.initials: AH
authors.lastname: DeCherney
authors.forename: R H
authors.initials: RH
authors.lastname: Reindollar
authors.forename: E E
authors.initials: EE
authors.lastname: Jones
mesh_terms: D010064:Embryo Implantation; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000494:pharmacology; D017274:Nafarelin / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017274:Nafarelin; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide