Inversion (14)(q11q32) in childhood T-cell acute lymphoblastic leukemia.
Inversion (14)(q11q32) is a common cytogenetic aberration in T-cell chronic lymphoid malignancies but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We describe two cases of childhood T-ALL in which inv(14)(q11q32) was present concomitantly with other karyotypic aberrations typical of T-ALL. The possible significance of inv(14) in these cases is also discussed.
Kwong
Y L
YL
University Department of Pathology, Queen Mary Hospital, Hong Kong.
Shing
M K
MK
Wan
T M
TM
Yuen
P M
PM
Chan
A Y
AY
Wong
K F
KF
Chan
L C
LC
D002648:Child; D002675:Child, Preschool; D007446:Chromosome Inversion; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology