Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs.
In the constant search for new compounds endowed with antitumor activity we have synthesized a series of anthraquinone hydrazones, which can bee seen either as opened-cycle modified anthrapyrazoles or as chromophore-modified anthracenediones. Seven 9,10-anthraquinone monoalkylaminoalkylhydrazones (3c-i) were synthesized from 10,10-dibromoanthrone (4) and a suitable N-alkylhydrazine. The hydrazones were converted into hydrochlorides and tested for their cytotoxic activity against L1210 murine leukemia cells. Two of them possess marginal activity in vitro.
Antonini
I
I
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Polucci
P
P
Cola
D
D
Palmieri
G
G
Martelli
S
S
Bontemps-Gracz
M
M
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice
D000880:Anthraquinones; D000970:Antineoplastic Agents; D006835:Hydrazones