Bedside assessment of skin-fold thickness. A useful measurement for distinguishing Cushing's disease from other causes of hirsutism and oligomenorrhea.
BACKGROUND
The known catabolic effects of glucocorticoid excess on protein metabolism prompted us to devise a method to assess this measure in reproductive-aged females with Cushing's disease. Since collagen protein is a major component of skin, decreased abundance of this protein should cause a reduction in skin-fold thickness. To determine whether skin-fold thickness is useful as an added tool in the diagnosis of Cushing's disease, we compared this value in female patients with Cushing's disease with those who presented with a similar set of symptoms.


METHODS
This open prospective study was conducted in an endocrinology clinic at a tertiary care center. The study population consisted of 88 females in the reproductive age group who presented to the clinic with hirsutism, oligomenorrhea, and/or obesity. Measurement of skin-fold thickness, body mass index, Ferriman-Gallwey index, and serum testosterone were performed in all patients.


RESULTS
Skin-fold thickness in the patients with Cushing's disease was 1.5 +/- 0.2 mm (range, 1.0 to 1.8 mm). This value was significantly (P < .01) lower than that in controls or subjects with other disorders that have a similar set of presenting symptoms.


CONCLUSIONS
Bedside assessment of skin-fold thickness is an easy, low-cost, and noninvasive test for distinguishing Cushing's disease from disorders with similar presenting symptoms in females of reproductive age. Assessment of skin-fold thickness should be used as an adjunct to current physical and biochemical study of patients with symptoms suggestive of Cushing's disease.
Corenblum
B
B
Department of Medicine, University of Calgary, Alberta.
Kwan
T
T
Gee
S
S
Wong
N C
NC
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003480:Cushing Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000209:etiology; D009839:Oligomenorrhea / Q000097:blood / Q000209:etiology*; D011446:Prospective Studies; D012885:Skinfold Thickness; D013739:Testosterone / Q000097:blood
D013739:Testosterone