Fatty acid compositions of plasma lipids in atopic dermatitis/asthma patients.
The proportions of linoleic acid in total plasma lipids and phospholipids were significantly greater and those of oleic acid were lower in pre-puberal and puberal atopic patients as compared with age-matched healthy controls. The n-3/n-6 fatty acid ratio of the triacylglycerol fraction was also lower in atopic patients. However, no significant decreases in the proportions of dihomo-gamma-linolenic acid and arachidonic acid were observed in plasma lipids of atopic patients, suggesting that delta 6-desaturase activity is not impaired in atopic patients. We provide an explanation for the beneficial effects of raising the n-3/n-6 ratio of dietary oils in the context of suppressing allergic hyper-reactivity in humans.
Sakai
K
K
Faculty of Pharmaceutical Sciences, Nagoya City University.
Okuyama
H
H
Shimazaki
H
H
Katagiri
M
M
Torii
S
S
Matsushita
T
T
Baba
S
S
D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000178:diet therapy; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood* / Q000178:diet therapy; D005227:Fatty Acids / Q000032:analysis*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000032:analysis; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis; D008055:Lipids / Q000097:blood*; D019301:Oleic Acid; D009829:Oleic Acids / Q000032:analysis; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D008041:Linoleic Acids; D008055:Lipids; D009829:Oleic Acids; D010743:Phospholipids; D014280:Triglycerides; D019301:Oleic Acid; D019787:Linoleic Acid