title: Case report: Castleman disease in association with POEMS.
abstract: Castleman disease, or angiofollicular lymph node hyperplasia, and POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), are associated and can lead to a clinical conundrum. The physician caring for a patient with Castleman disease should be alert to the development of multiple endocrine deficiencies, including primary hypogonadism, diabetes mellitus, hypothyroidism, and adrenal insufficiency. Avoidance of treating hypothyroidism alone when there is concomitant subclinical adrenal insufficiency is important, to avoid precipitating an adrenal crisis. A better outcome may result from earlier recognition of the endocrinopathies of this syndrome. This article describes a patient with Castleman disease in whom the features of POEMS unfolded over the ensuing years.
authors.affiliation: Department of Internal Medicine, University of South Florida Health Sciences Center, Tampa.
authors.forename: H M
authors.initials: HM
authors.lastname: Adelman
authors.forename: M L
authors.initials: ML
authors.lastname: Cacciatore
authors.forename: J F
authors.initials: JF
authors.lastname: Pascual
authors.forename: J M
authors.initials: JM
authors.lastname: Mike
authors.forename: W M
authors.initials: WM
authors.lastname: Alberts
authors.forename: P M
authors.initials: PM
authors.lastname: Wallach
mesh_terms: D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007037:Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone