Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study.
A multifaceted approach that involves early debridement and control of infection is critical to successful and rapid burn wound healing. This pilot study was conducted in 15 adult patients with burns to assess the usefulness of early enzymatic debridement with a combination of collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns. Combination treatment with collagenase and polymyxin B sulfate/bacitracin resulted in significantly shorter time to achieve a clean wound bed than silver sulfadiazine (median 6 vs 12 days; p = 0.0012) and significantly more rapid wound healing than silver sulfadiazine (median 10 vs 15 days; p = 0.0007). These results are encouraging and justify implementation of a larger, multicenter, comparative study.
Soroff
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HS
Department of Surgery, Health Sciences Center, SUNY at Stony Brook 11794-8191.
Sasvary
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DH
D000328:Adult; D000336:Aerosols; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001414:Bacitracin / Q000008:administration & dosage / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy*; D017364:Collagenases / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use; D009824:Ointments; D010865:Pilot Projects; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology
D000336:Aerosols; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009824:Ointments; D001414:Bacitracin; C001816:bacitracin zinc, neomycin sulfate, polymyxin B, drug combination; D017364:Collagenases; D009355:Neomycin; D011112:Polymyxin B; D012837:Silver Sulfadiazine