title: [Study of anti-HIV activity of azidothymidine and fluorothymidine 5'-phosphonates].
abstract: It was established that 5'-phosphonates of 3'-azido-2',3'-dideoxythymidine (AZT) inhibit HIV reproduction in the MT-4 cell line as well as AZT. However, the viability of HIV-infected MT-4 cells after treatment with phosphonates was considerable higher that after AZT treatment. Inhibitory activities of 5'-phosphonates of 3'-fluoro-2',3'-dideoxythymidine (FLT) on HIV-infected MT-4 cells were rather low. The mechanism of action of these derivatives and prospects for their application for suppressing HIV infection are discussed.
authors.forename: O A
authors.initials: OA
authors.lastname: Mamaeva
authors.forename: O A
authors.initials: OA
authors.lastname: Pliasunova
authors.forename: A G
authors.initials: AG
authors.lastname: Pokrovskiĭ
authors.forename: N B
authors.initials: NB
authors.lastname: Diatkina
authors.forename: A A
authors.initials: AA
authors.lastname: Arzumanova
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival; D002478:Cells, Cultured; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D009943:Organophosphorus Compounds; C068636:2'-fluorothymidine; D015215:Zidovudine; D013936:Thymidine
vernacular_title: Izuchenie anti-HIV-aktivnosti 5'-fosfonatov azidotimidina i ftortimidina.