Pure red cell aplasia of pregnancy: a distinct clinical entity.
We describe a 31-year-old patient with pure red cell aplasia of pregnancy, successfully managed with regular blood transfusions. In vitro studies showed specific inhibition of day 14 erythroid colonies (BFU-E) using serum and purified immunoglobulin G (IgG) obtained from the patient at diagnosis (before blood transfusion). The inhibition of BFU-E disappeared when haematological remission occurred 3 weeks after delivery and she remains clinically well with a normal haemoglobin 4 years later.
Baker
R I
RI
Department of Clinical Haematology, St George Hospital, Sydney, Australia.
Manoharan
A
A
de Luca
E
E
Begley
C G
CG
D000328:Adult; D001803:Blood Transfusion; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000209:etiology* / Q000628:therapy
D004921:Erythropoietin