title: Psychiatric morbidity in the first-degree relatives of schizophrenic patients.
abstract: First-degree relatives (FDRs) of 162 schizophrenic and 106 control probands were investigated [corrected]. Psychiatric morbidity was present in 34.8% of FDRs of schizophrenic probands and in 9.2% of FDRs of controls. There was significantly more psychiatric illness in the siblings and parents than in the offspring of both schizophrenic and control subjects. The morbidity risks for schizoid-schizotypal personality disorders, cannabis-use disorder and paranoid personality disorder were significantly higher in the FDRs of schizophrenic patients than in those of controls, suggesting a biological relationship.
authors.affiliation: Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan.
authors.forename: S L
authors.initials: SL
authors.lastname: Varma
authors.forename: I
authors.initials: I
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D002188:Cannabis; D005260:Female; D003932:Heroin; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D019966:Substance-Related Disorders / Q000150:complications / Q000523:psychology
chemical_list: D003932:Heroin