Cytogenetic findings in primary uveal melanoma.
We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.
Singh
A D
AD
Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania.
Boghosian-Sell
L
L
Wary
K K
KK
Shields
C L
CL
De Potter
P
P
Donoso
L A
LA
Shields
J A
JA
Cannizzaro
L A
LA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000235:genetics* / Q000473:pathology