Nonsteroidal anti-inflammatory drug-induced diaphragm disease arising in a bypassed ileal segment.
The formation of mucosal ileal diaphragms has been previously reported in patients receiving nonsteroidal anti-inflammatory drugs over extended periods of time. Whether this effect is the result of a local or systemic action by the medication has remained unknown. We report the first known instance of diaphragm disease arising in a segment of ileum that had been bypassed for many years and therefore was not exposed normally to luminal contact with the drug. This case supports at least a partial systemic mechanism in the production of the lesion.
Monihan
J M
JM
Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC.
Hensley
S D
SD
Sobin
L H
LH
D000368:Aged; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D007082:Ileum / Q000473:pathology* / Q000601:surgery; D007413:Intestinal Mucosa / Q000473:pathology; D007581:Jejunoileal Bypass; D017116:Low Back Pain / Q000188:drug therapy; D008297:Male; D013997:Time Factors
D001241:Aspirin