Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver.
Male Wistar rats were fed a control diet or the control diet supplemented with 1% (by weight) turmeric for 10 wk. In rats injected with 30 mg Fe2+/kg body weight, lipid peroxidation was 29 and 35% lower in liver homogenates and microsomes, respectively, of turmeric-fed rats than in those of rats fed the control diet. The activities of superoxide dismutase, catalase and glutathione peroxidase were higher (by 19, 19 and 20%, respectively) in liver homogenates of rats fed the turmeric-containing diet in comparison with the controls. These studies indicate that dietary turmeric lowers lipid peroxidation by enhancing the activities of antioxidant enzymes.
Reddy
A C
AC
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
Lokesh
B R
BR
D000818:Animals; D002374:Catalase / Q000378:metabolism; D030024:Curcuma; D003474:Curcumin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D004032:Diet; D005296:Ferrous Compounds / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D012717:Sesquiterpenes; D013482:Superoxide Dismutase / Q000378:metabolism
D005296:Ferrous Compounds; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D012717:Sesquiterpenes; C020748:ferrous sulfate; C086829:alpha-curcumene; C012596:turmeric extract; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003474:Curcumin