title: The role of transplantation in small hepatocellular carcinoma complicating cirrhosis of the liver.
abstract: Of 176 hepatic transplants performed from 1986 to December 1992, 27 patients had small hepatocellular carcinoma (< or = 5 centimeters) complicating cirrhosis of the liver. All patients were asymptomatic for the hepatic malignancy and the diagnosis was established in each instance preoperatively by means of serial sonographic scans and alpha-fetoprotein levels. Cirrhosis was classified as Child's A in eight instances, as Child's B in 16 and Child C's in three. The cause was alcoholic in three patients, posthepatitic in 21 patients (eight hepatitis B virus [HBV] positive and 13 hepatitis C virus [HCV] positive) and undetermined in three. The in-hospital mortality rate was 11 percent (three of 27). Additionally, five patients died at different intervals after transplantation: only two died of neoplastic recurrence at 12 and 32 months, respectively (7.4 percent rate). Actuarial survival rates were 82 percent at one year and 71 percent at three years, with a mean follow-up period of 32 months (range six to 78 months). Morbidity related to the procedure was a relevant problem: 21 percent of the patients had prompt resumption of normal life while 37 percent required repeated hospitalization and 42 percent required strict control on an outpatient basis. The most frequent problem was HBV or HCV reinfection of the grafted liver, which occurred in 42 percent. Based on this experience, transplantation of the liver has shown an excellent oncologic accuracy for small hepatocellular carcinoma in cirrhosis of the liver, thus representing the most rational surgical procedure for patients with Child's B and Child's C cirrhosis classification. The relevant mortality and morbidity rates, strictly related to this procedure, suggest other options as more appropriate in those with Child A cirrhosis at this time.
authors.affiliation: Department of Surgery Transplantation Unit Pizzamiglio 11, Niguarda Hospital, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Romani
authors.forename: L S
authors.initials: LS
authors.lastname: Belli
authors.forename: G F
authors.initials: GF
authors.lastname: Rondinara
authors.forename: L
authors.initials: L
authors.lastname: DeCarlis
authors.forename: P
authors.initials: P
authors.lastname: Rimoldi
authors.forename: F
authors.initials: F
authors.lastname: Riolo
authors.forename: G
authors.initials: G
authors.lastname: Bellati
authors.forename: G
authors.initials: G
authors.lastname: Ideo
authors.forename: L
authors.initials: L
authors.lastname: Belli
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000601:surgery; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000601:surgery; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D009364:Neoplasm Recurrence, Local; D015996:Survival Rate