title: Urinary concentration of corticoids in normal horses and horses with hyperadrenocorticism.
abstract: The urinary corticoid:creatinine (c:c) ratio was determined in eight horses with hyperadrenocorticism (HAC). The mean (+/- SD) urinary c:c ratio of the eight horses with HAC (29 +/- 14 x 10(-6)) was significantly (P < 0.05) greater than the ratio in seven control horses (11 +/- 4.3 x 10(-6)). The urinary concentration of corticoids in control horses (201 +/- 60.4 nmol litre-1) was significantly (P < 0.05) lower than in horses with HAC (664 +/- 291 nmol litre-1). The urinary creatinine concentrations did not differ significantly (P > 0.05) between both groups. As both false negative and false positive cases were found, it is concluded that a measurement of the urinary c:c ratio in the horse should not be used as the sole test to confirm equine HAC.
authors.affiliation: Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: van der Kolk
authors.forename: H C
authors.initials: HC
authors.lastname: Kalsbeek
authors.forename: T
authors.initials: T
authors.lastname: Wensing
authors.forename: H J
authors.initials: HJ
authors.lastname: Breukink
mesh_terms: D000305:Adrenal Cortex Hormones / Q000652:urine*; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis / Q000652:urine / Q000662:veterinary*; D000818:Animals; D003404:Creatinine / Q000652:urine; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000652:urine*; D006736:Horses; D006854:Hydrocortisone / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D003404:Creatinine; D006854:Hydrocortisone