Effect of antibiotics on protein synthesis in filarial parasites.
Acanthocheilonema viteae, Litomosoides carinii and Setaria cervi were found to actively synthesize proteins in vitro. Different centrifugation fractions and their TCA-precipitable fractions were assessed for the distribution of newly synthesized proteins. Penicillin and streptomycin inhibited the process in A. viteae. The synthesis in S. cervi was susceptible to puromycin, chloramphenicol, cycloheximide, neomycin and polymyxin B. The process in L. carinii was strongly blocked by puromycin while chloramphenicol had no significant effect.
Wani
J H
JH
Division of Biochemistry, Central Drug Research Institute, Lucknow, U.P., India.
Srivastava
V M
VM
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002020:Buffaloes; D002701:Chloramphenicol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D004153:Dipetalonema / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005370:Filarioidea / Q000187:drug effects* / Q000378:metabolism; D015801:Helminth Proteins / Q000096:biosynthesis*; D008297:Male; D008925:Mites; D009115:Muridae; D009355:Neomycin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D011112:Polymyxin B / Q000494:pharmacology; D011691:Puromycin / Q000494:pharmacology; D017182:Setaria Nematode / Q000187:drug effects* / Q000378:metabolism; D016205:Sigmodontinae; D013307:Streptomycin / Q000494:pharmacology
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D015801:Helminth Proteins; D010406:Penicillins; D011691:Puromycin; D002701:Chloramphenicol; D003513:Cycloheximide; D009355:Neomycin; D011112:Polymyxin B; D013307:Streptomycin