[The pharmacological mechanisms of the radioprotective effect under whole-body conditions and the prospects of the search for radioprotectors].
On the basis of the current views of the pharmacological agents action and the analysis of the structural and functional mechanisms of the radioprotection realization a unitary hypothesis of the radioprotective effect development has been formulated. Three stages of its development in animals and humans have been distinguished. The proposed hypothesis allows to substantiate a strategy of the search for new antiradiation drugs.
Vladimirov
V G
VG
Krasil'nikov
I I
II
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004347:Drug Interactions; D006801:Humans; D011832:Radiation Injuries / Q000517:prevention & control; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000009:adverse effects / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents
Farmakologicheskie mekhanizmy radiozashchitnogo éffekta v usloviiakh tselostnogo organizma i perspektivy izyskaniia radioprotektorov.