Serotonin receptor subtypes and affective disorders.
The role of drugs that act at 5-hydroxytryptamine (5-HT or serotonin) receptor subtypes in the etiology and treatment of affective disorders is discussed. The mechanisms of action of drugs affecting 5-HT are described, with emphasis on those with anxiolytic and antidepressant activity. Evidence supporting a role for serotonin in the etiology and treatment of affective disorders in cited. Recent therapeutic advances have resulted in a new generation of serotonergic drugs.
Robinson
D S
DS
Central Nervous System Clinical Research, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492-7660.
D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy* / Q000209:etiology*; D011985:Receptors, Serotonin / Q000145:classification* / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists