title: Chromosomic findings in patients with paroxysmal nocturnal hemoglobinuria.
abstract: The chromosomes of 14 patients (9 males, 5 females) suffering from paroxysmal nocturnal hemoglobinuria in Merida, Mexico between April 1989 and July 1992 were analyzed. Four of the patients were children (range, 3-15 years old) and 9 were adults (range, 19-62 years old). None of the patients had any evidence of leukemic transformation and 9 of them had antecedent insecticide exposure. In 50%, the clinical presentation was anemia plus hemorrhagic syndrome. Only 1 case had thrombosis. The lapse between the beginning of the disease and the karyotypic analysis was 14.5 months on average (range, 1-172 months). In all cases we found a normal chromosomic complement. In addition, 5 patients had an acentric fragment in only 1 metaphase and one of these had a mar and Cq chromatid break in another metaphase, but neither could be considered as specific chromosomal abnormality for paroxysmal nocturnal hemoglobinuria.
authors.affiliation: Department of Hematology, Dr. Hideyo Noguchi Regional Research Center, University of Yucatan, Mexico.
authors.forename: R A
authors.initials: RA
authors.lastname: Gongora-Biachi
authors.forename: P
authors.initials: P
authors.lastname: Gonzalez-Martinez
authors.forename: D
authors.initials: D
authors.lastname: Pinto-Escalante
authors.forename: J M
authors.initials: JM
authors.lastname: Ceballos-Quintal
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies