[A model of orthotopic transplantation of human hepatoma established in nude mice tumor inhibition studies].
We established a model of orthotopic transplantation of human hepato-carcinoma. The tissues from human hepatoma LTNM4 were surgically implanted into the livers of 32 BALB/c nu/nu nude mice. These led to the development of tum or masses in the livers of 31 nude mice; the rate of success was about 96.8% (31/32). Furthermore, this model was applied to the studies on the tumor inhibitory action of DHAQ-PBCA-NS, a hepatic targeting preparation for anticarcinoma. Satisfactory effect was attained. The result has proved the applicability of this animal model to researches on hepatic targeting preparations against carcinoma.
Bai
S
S
Zhang
X
X
Xie
C
C
Hou
S
S
Zhang
Z
Z
Liao
G
G
D000818:Animals; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D008113:Liver Neoplasms; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008942:Mitoxantrone / Q000008:administration & dosage; D009368:Neoplasm Transplantation
D008942:Mitoxantrone