title: Pro and anticonvulsant effects of xylazine on convulsion models in rodents.
abstract: Pretreatment of mice with 30 mg xylazine/kg ip protected against convulsions induced by amphetamine, but it intensified pentylenetetrazole- and strychnine-induced seizures. Xylazine pretreatment also protected rats against electroshock-induced convulsions. These findings support a noradrenergic mechanism being involved in the proconvulsant and/or anticonvulsant effects of xylazine.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Brazil.
authors.forename: H de S
authors.initials: Hde S
authors.lastname: Spinosa
authors.forename: S L
authors.initials: SL
authors.lastname: Gorniak
authors.forename: J
authors.initials: J
authors.lastname: Palermo-Neto
authors.forename: M M
authors.initials: MM
authors.lastname: Bernardi
authors.forename: F R
authors.initials: FR
authors.lastname: Spinosa
mesh_terms: D000661:Amphetamine; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003292:Convulsants / Q000633:toxicity*; D004597:Electroshock; D005260:Female; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control*; D013331:Strychnine; D014991:Xylazine / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D014991:Xylazine; D000661:Amphetamine; D013331:Strychnine; D010433:Pentylenetetrazole