[The clinical efficacy of plasmapheresis in the combined therapy of patients with chronic glomerulonephritis and nephrotic syndrome].
A clinical analysis of the effect of 64 plasmapheresis sessions in combined treatment of 16 chronic glomerulonephritis patients with nephrotic syndrome was made for 7 patients with mesangiocapillary, 1 with mesangioproliferative, 2 with mesangioproliferative with semilunums, 2 with fibroplastic glomerulonephritis. 12 of the patients had failed previous chemotherapy with prednisolone, curantil, cyclophosphamide. Each of the patients underwent 3-5 sessions of plasmapheresis. The domestic-made centrifuge pi phi-05 was employed. Plasmapheresis was combined with prednisolone (1.5 mg/kg/day) as early as session 1 in 6 patients, session 3 in 10 patients (pulse therapy with 1 mg). Plasmapheresis was followed by curantil and chlorbutin administration. The results evaluated 2 months after the treatment start showed that renal function became normal in 4 patients, proteinuria diminished by 50-80% in 9 cases, nephrotic syndrome transformed into the urinary one in 5 patients.
Kolesnik
N A
NA
Dudar'
I A
IA
Velichko
M B
MB
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000628:therapy*; D010956:Plasmapheresis / Q000379:methods
Klinicheskaia éffektivnost' plazmafereza v kompleksnoĭ terapii bol'nykh khronicheskim glomerulonefritom s nefroticheskim sindromom.