[Effects of purified VLDL injection on experimental hyperlipidaemia].
Forty-two neonate NZW rabbits were randomly allocated to two experimental groups (II and III) and a control group (I). Groups II and III were intraperitoneally injected with purified VLDL 0.5mg and 1.0mg, respectively within 12 hours after their birth, and then were repeated with same doses twice on the 7th and 15th day, respectively. From the 18th day of their life, all the rabbits were fed with high cholesterol forage to establish atherosclerosis models. Serum levels of TG, TCh, and HDL-C were determined in the 17th, 30th, and 40th week of their life. Serum levels of TG in Groups II and III were much lower than those in Group I in the 17th week. Serum levels of TG and ratio of LDL-C to HDL-C were significantly lower and of HDL-C much higher in Groups II and III than those in Group I in the 30th week. The results determined in the 40th week were the same as above, and serum levels of TCh in Groups II and III were significantly lower than those in Group I. There Were no significant differences in serum levels of LDL-C and TCh among the three groups. The results suggested peritoneal injection of purified VLDL into rabbits in their earliest stage of life had effects on the formation of hyperlipidaemia, and could Prevent them from atherosclerosis. Its mechanism was briefly discussed in the paper.
Li
S C
SC
Department of Epidemiology Shandong Medical University, Jinan.
D000818:Animals; D000831:Animals, Newborn; D001161:Arteriosclerosis / Q000517:prevention & control*; D006949:Hyperlipidemias / Q000209:etiology*; D007274:Injections, Intraperitoneal; D008079:Lipoproteins, VLDL / Q000008:administration & dosage*; D008297:Male; D011817:Rabbits; D011897:Random Allocation
D008079:Lipoproteins, VLDL