[The effect of pyridinolcarbamate (parmidine) on the microcirculation and immunity of patients with stable angina].
A comparison of the efficacy of treating two patient group (Group 1, patients receiving nitrates in combination with parmidin and Group 2, those taking nitrates) revealed that the two groups did not differ greatly in the clinical effects. In heart failure patients with high capillary permeability, parmidin substantially decreased the permeability to protein, which was associated with decreases in the baseline high activity of primary lipid peroxidation product in plasma red blood cells, which was not observed in the controls. At the same time parmidin was demonstrated to exert an unfavourable effect on microhemocirculation and to increase the patient's autosensibilisation.
Atroshchenko
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ES
Karpova
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D000787:Angina Pectoris / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D000917:Antibody Formation / Q000187:drug effects; D015551:Autoimmunity / Q000187:drug effects; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D005082:Physical Exertion / Q000187:drug effects; D011727:Pyridinolcarbamate / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D009566:Nitrates; D011727:Pyridinolcarbamate
Vliianie piridinolkarbomata (parmidina) na mikrotsirkuliatsiiu i immunitet bol'nykh so stabil'noĭ stenokardieĭ.