title: Limitations of adenosine in assessing the efficacy of radiofrequency catheter ablation of accessory pathways.
abstract: Adenosine has been shown to reliably confirm the success of accessory pathway catheter ablation by producing transient atrioventricular (AV) block during atrial and ventricular pacing. This is due to the insensitivity of accessory pathway conduction to adenosine (with the rare exception of accessory pathways with decremental conduction properties). However, 4 of 204 consecutive patients who underwent successful accessory pathway ablation (as shown by adenosine-induced transient AV block) had recurrent AV reciprocating tachycardia involving a second, previously nonmanifest accessory pathway. In each case, the second accessory pathway was localized to a site disparate from the original pathway. No pathway showed decremental anterograde or retrograde conduction properties. In 2 patients, adenosine initially did not show the presence of the second concealed accessory pathway, because the refractory period of the accessory pathway was longer than the pacing cycle length used to assess ventriculoatrial conduction. Only when the refractory period of this second accessory pathway was shortened by infusion of isoproterenol did adenosine reveal the presence of the pathway during follow-up electrophysiologic study. In another patient, a non-decremental accessory pathway was shown to be sensitive to adenosine. In the remaining patient, the second accessory pathway may have been transiently injured during the initial study, thereby simulating adenosine sensitivity.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021.
authors.forename: E D
authors.initials: ED
authors.lastname: Engelstein
authors.forename: D
authors.initials: D
authors.lastname: Wilber
authors.forename: M
authors.initials: M
authors.lastname: Wadas
authors.forename: K M
authors.initials: KM
authors.lastname: Stein
authors.forename: N
authors.initials: N
authors.lastname: Lippman
authors.forename: B B
authors.initials: BB
authors.lastname: Lerman
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000328:Adult; D001283:Atrioventricular Node / Q000002:abnormalities / Q000187:drug effects / Q000601:surgery*; D017115:Catheter Ablation; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D013610:Tachycardia / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000241:Adenosine; D007545:Isoproterenol