[Calcitonin gene-related peptide (CGRP): a vasodilator neuropeptide with many potential applications].
CGRP (calcitonin gene-related peptide) is a potent vasodilator neuropeptide which acts on peri-arteriolar neurones and is implicated in the pathogenesis of numerous cardiovascular diseases. The synthesis of CGRP antagonists should be useful for the treatment of Raynaud's disease as well as migraine. There exists an homology between the structures of CGRP and pancreatic amylin and therefore an eventual role of CGRP in type II diabetes pathophysiology is currently being studied.
Grunenberger
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Service de Médecine Interne, CHRU, Hôpital de Hautepierre, Strasbourg, France.
D000450:Aldosterone / Q000096:biosynthesis; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004066:Digestive System Diseases / Q000503:physiopathology; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy*; D012083:Renin / Q000096:biosynthesis; D014664:Vasodilation / Q000187:drug effects*
D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin; D015740:Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide (CGRP): un neuropeptide vasodilatateur aux nombreuses potentialités.