title: The t(14;18) in a patient with de novo acute lymphoblastic leukemia is associated with t(8;9).
abstract: Cytogenetic analysis of a bone marrow aspirate from a patient with acute lymphoblastic leukemia (ALL) revealed the presence of a complex karyotype containing the translocation, t(14;18)(q32;q21). Further investigations using fluorescence in situ hybridization (FISH) allowed the characterization of an additional translocation, t(8;9)(q24;p1?). The association of t(14;18)(q32;q21) and t(8;9)(q24;p13) has recently been described in two patients with de novo ALL (Nacheva et al. Blood 1993;82:231-240) and this report supports these findings.
authors.affiliation: ICRF Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Lillington
authors.forename: S
authors.initials: S
authors.lastname: Monard
authors.forename: P W
authors.initials: PW
authors.lastname: Johnson
authors.forename: M L
authors.initials: ML
authors.lastname: Evans
authors.forename: L U
authors.initials: LU
authors.lastname: Kearney
authors.forename: T A
authors.initials: TA
authors.lastname: Lister
authors.forename: B D
authors.initials: BD
authors.lastname: Young
authors.forename: B
authors.initials: B
authors.lastname: Gibbons
mesh_terms: D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic