[Inductive differentiation effect of ginsenosides on human acute non-lymphocytic leukemic cells in 58 patients].
Ginsenosides are the main active component of Panax ginseng. It has been shown that ginsenosides have antineoplastic, antiaging, immunologic function enhancing and other pharmacological actions. In this article, result of experimental studies showed ginsenosides extracted from stem and leaf of Panax ginseng (GSL) has inductive differentiation effect on all types of acute nonlymphocytic leukemia cells in primary culture. The effect on M5, M4 was most potent, followed by M1, M2 and the least, on M3. Through analysis, it was considered that the inductive differentiation effect of ginsenosides might be due to the comprehensive effect of increasing intracellular cAMP and inducing interferon. Since GSL have some other important actions, therefore, if it could be used as a differentiation inducer in clinical practice or combined with other antineoplastic drugs, it would show co-antineoplastic actions in many aspect.
Yi
R L
RL
First Teaching Hospital, Norman Bathune Medical University of Medical Sciences, Changchun.
Li
W
W
Hao
X Z
XZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005260:Female; D036145:Ginsenosides; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D005894:Panax; D010946:Plants, Medicinal; D012503:Saponins / Q000627:therapeutic use*
D036145:Ginsenosides; D012503:Saponins