Lactate mapping with full sensitivity by spin-filtered NMR imaging.
The mechanism of the fourfold signal loss during the cyclic polarization-transfer (CYCLPOT) sequence for lactate filtering is analyzed using the spin-product-operator formalism. Based on the results of the analysis, a new sequence, RECYCLPOT (refocused CYCLPOT), is proposed and experimentally tested for lactate filtering with full sensitivity and specificity. Lactate mapping is performed by spin filtering using the RECYCLPOT sequence prior to imaging by spatial encoding.
Zhang
W
W
Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Ho
C
C
D000818:Animals; D007091:Image Processing, Computer-Assisted; D007773:Lactates / Q000737:chemistry*; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D007773:Lactates; D019344:Lactic Acid