[Polypharmacotherapy: the risk of developing postoperative hemorrhages].
The impact of polypragmasy on the causes of endogenic heparinemia in the early postoperative period was studied in patients operated on the heart under extracorporeal circulation. It has been found that polypragmasy does not break down the heparin-protamine sulfate complex, but impairs the process of its formation to a certain degree. Ascorbic acid lowers the activity of heparin and hence it may be used as a hemostatic stabilizer during endogenous heparinemia.
Dement'eva
I I
II
Roĭtman
E V
EV
Pechennikov
V M
VM
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D004359:Drug Therapy, Combination; D064420:Drug-Related Side Effects and Adverse Reactions; D005112:Extracorporeal Circulation; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D006493:Heparin / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D011485:Protein Binding / Q000187:drug effects; D012189:Retrospective Studies
D001798:Blood Proteins; D006493:Heparin
Polifarmakoterapiia: risk razvitiia posleoperatsionnykh krovotecheniĭ.