title: The effect of dietary lipid changes on the fatty acid composition and function of liver, heart and brain mitochondria in the rat at different ages.
abstract: A correlation between dietary lipids and cellular enzyme activities is a problem that has only been partially addressed by nutritionists. Therefore, changes in the fatty acid composition and the activities of some key metabolic enzymes (ubiquinol-2-cytochrome c reductase (EC 1.10.2.2), cytochrome oxidase (EC 1.9.3.1) and ATPase (EC 3.6.1.3)) in the mitochondria of liver, heart and brain of rats fed on diets differing extensively in their polyunsaturated fatty acid compositions have been investigated. The results showed that fatty acid compositional changes brought about by the dietary differences were associated with extensive changes in the activities of these key enzymes in the mitochondria. The extent of the influence differed considerably with the period over which the diets were fed. The role of dietary lipids to effect changes through the preservation of membrane structural integrity is discussed.
authors.affiliation: Department of Biochemistry, University of Bologna, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Barzanti
authors.forename: M
authors.initials: M
authors.lastname: Battino
authors.forename: A
authors.initials: A
authors.lastname: Baracca
authors.forename: M
authors.initials: M
authors.lastname: Cavazzoni
authors.forename: M
authors.initials: M
authors.lastname: Cocchi
authors.forename: R
authors.initials: R
authors.lastname: Noble
authors.forename: M
authors.initials: M
authors.lastname: Maranesi
authors.forename: E
authors.initials: E
authors.lastname: Turchetto
authors.forename: G
authors.initials: G
authors.lastname: Lenaz
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D014450:Electron Transport Complex III / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases; D014450:Electron Transport Complex III