Hypoglycemia caused by selegiline, an antiparkinsonian drug: can such side effects be predicted?
Treatment with selegiline produced profound hypoglycemia in a 70-year-old man with Parkinson's disease. The hypoglycemia was accompanied by hyperinsulinemia and persisted for 1 week after selegiline was discontinued. Although this side effect of antidepressant monoamine oxidase inhibitors was well documented in 1959-1968 publications, it was not known to the manufacturer of selegiline. Effects of drugs on glucose metabolism may be predictable through a novel molecular modeling technique developed in our laboratories, which shows that glucose exhibits stereochemical complementarity to a specific site in partially unwound DNA. Selegiline and other molecules affecting glucose metabolism fit into the same DNA base sequence. It therefore should be possible to employ this technique to identify pharmaceutical agents that possess hypoglycemic or hyperglycemic effects in vivo.
Rowland
M J
MJ
Department of Medicine, Medical College of Georgia, Augusta 30912-3115.
Bransome
E D
ED
Hendry
L B
LB
D000368:Aged; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood / Q000737:chemistry; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000737:chemistry; D009690:Nucleic Acid Conformation; D010300:Parkinson Disease / Q000188:drug therapy*; D012642:Selegiline / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use
D007328:Insulin; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D004247:DNA; D005947:Glucose