[Genetic and environmental factors implicated in recurrent calcium lithiasis].
In this prospective study, we compared the frequency of some genetic and environmental factors possibly implicated in the occurrence of calcium stone disease. A group of 439 patients (258 males and 181 females) with one episode of calcium stone was compared to a group of 191 patients (131 males and 60 females) with recurrent calcium stone disease. Population with stones was also compared to control population (n = 78, 40 males and 38 females) matched to age. Major results were as follow: 1) Family history of urinary calculi was more frequent in patients than in controls (28.4% vs 9%, p < 0.01). No difference was observed between patients with one episode and those with recurrent episodes (27% vs 31%, ns). 2) The recurrence was earlier in female than in male, so that in female with family history of urinary calculi (p < 0.05). 3) Mean plasma levels of 1-25OH2D3 was significantly higher in patients with family history than in controls (60% vs 38%, p < 0.01) 5) Restricted calcium diet (< 400 mg per day) was more often observed in patients than in controls (31% vs 14%, p < 0.05) and the most significant difference was found in patients with recurrent calcium stones.
Ang
K S
KS
Service de Néphrologie, Centre Hospitalier La Beauchée.
Mighard
J P
JP
Triffard
F
F
Cloup
C
C
Carlier
M
M
Catroux
B
B
Cam
G
G
Benziane
A
A
Simon
P
P
D000328:Adult; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood / Q000652:urine; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D014545:Urinary Calculi / Q000209:etiology* / Q000235:genetics*
D002117:Calcitriol; D002118:Calcium
Facteurs génétiques et environnementaux impliqués dans la lithiase calcique récidivante.