[Transport of 2,5-dimethoxy-4-methylamphetamine by macroheterocycles across erythrocyte membranes].
Transport of 2,5-dimethoxy-4-methylamphetamine across human erythrocytes by the 18-crown-6, monoaza-15-crown-5 and diaza-18-crown-6 is studied and evaluated spectrophotometrically. It is shown that crown-ethers at low concentration (1-2 mM) protect erythrocytes against their natural homolysis. 2,5-dimethoxy-4-methylamphetamine provides 2-5% hemolysis of erythrocytes. In the presence of macrocycles (5 mM) hemolysis of erythrocytes increases from 6.5 to 30%. A hemolytic effect of 2,5-dimethoxy-4-methylamphetamine depends on the structure of the crown ethers and, apparently, confirms significant role of complexes of the crown-ethers with amine in these processes.
Karaseva
T L
TL
Iavorskiĭ
A S
AS
Pavlovskiĭ
V I
VI
Tsapenko
Zh N
ZhN
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000493:pharmacokinetics*; D001692:Biological Transport / Q000502:physiology; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000378:metabolism*; D006801:Humans
D006571:Heterocyclic Compounds; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine
Transport 2,5-dimetoksi-4-metilamfetamina makrogeterotsiklami cherez membrany éritrotsitov.