Prevalence of peptic ulcer in Helicobacter pylori positive blood donors.
This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought.
Vaira
D
D
1st Medical Clinic, University of Bologna, Italy.
Miglioli
M
M
Mulè
P
P
Holton
J
J
Menegatti
M
M
Vergura
M
M
Biasco
G
G
Conte
R
R
Logan
R P
RP
Barbara
L
L
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D001782:Blood Donors; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000453:epidemiology*; D004382:Duodenitis / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013276:Stomach Ulcer / Q000175:diagnosis / Q000453:epidemiology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G