[The pharmacokinetic interaction of propranolol and nifedipine in patients with angina of effort].
A comprehensive study was undertaken to examine the pharmacokinetic and pharmacodynamic interaction of propranolol and nifedipine in 11 patients with stable angina of effort who were treated for a long time. It was shown that when the agents were given in combination, the patient's plasma generated the same profiles of their concentrations as used alone. This suggests that the propranolol + nifedipine combination is safe from the point of their pharmacokinetic interaction. The latter occurs at the level of their pharmacodynamic effects.
Kukushkin
S K
SK
Rumiantsev
D O
DO
Belolipetskaia
V G
VG
Kokurina
E V
EV
Piotrovskiĭ
V K
VK
Metelitsa
V I
VI
D000787:Angina Pectoris / Q000097:blood* / Q000188:drug therapy; D002908:Chronic Disease; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005082:Physical Exertion / Q000187:drug effects*; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D011433:Propranolol; D009543:Nifedipine
Izuchenie farmakokineticheskogo vzaimodeĭstviia propranolola i nifedipina u bol'nykh so stenokardieĭ napriazheniia.