title: [Population genetics, immunologic evaluation and Buerger's disease. Projection through a personal study comprising 127 cases of juvenile arteriopathy].
abstract: The analysis of anamnestic, clinical and arteriographic parameters in 127 young patients with arterial disease of the lower limbs allowed a definite distinction between thromboangiitis obliterans (TAO) and early-onset atheroma, even if the etiopathogenic of TAO is still obscure. The HLA gene frequency has been determined in 54 patients (14 TAO, 40 early atheroma) and has been compared with local blood donors and with caucased subjects from the IXth Workshop. The results (higher frequency of HLA A28, AX, B53 and BX in the TAO group) have, however, a dubious significance. Furthermore, there were no differences between TAO and early atheroma in a comparative study of immunological parameters (anti-nuclear antibodies, circulating immune complexes, C3, C4 and CH50, cryoglobulin) in 72 patients (22 TAO, 50 early atheroma). So, neither a genetic predisposition nor a dysimmunity could be involved in the pathogenesis of TAO.
authors.affiliation: Service de Médecine H-Hôpital Central (CHRU), Nancy.
authors.forename: J
authors.initials: J
authors.lastname: Schmitt
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.forename: C
authors.initials: C
authors.lastname: Alan
authors.forename: C
authors.initials: C
authors.lastname: Haller
authors.forename: P
authors.initials: P
authors.lastname: Perrier
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000235:genetics* / Q000276:immunology; D005500:Follow-Up Studies; D005787:Gene Frequency; D006801:Humans; D013919:Thromboangiitis Obliterans / Q000235:genetics* / Q000276:immunology
vernacular_title: Génétique des populations, bilan immunitaire et maladie de Buerger. Projection à travers une étude personnelle regroupant 127 cas d'artériopathies juvéniles.