Perspectives of monoclonal antibodies for detection and treatment of head and neck tumours.
Monoclonal antibodies (mabs) are potentially powerful tools for the detection and treatment of cancer. To date, only a limited number of mabs are available to head and neck cancer. We produced 5 different groups of mabs to head and neck cancer. These mabs were characterized for their reactivity tumour and non-tumour tissues. Furthermore, biochemical elucidation of recognized antigens was provided. In animal studies the effectiveness of mabs for diagnoses and therapy of cancer is clearly demonstrated. The first results of a clinical study for the detection of head and neck cancer with mabs are shown. Finally, the future of mabs in clinical oncology is discussed.
Quak
J
J
University Hospital, Department of Otolaryngology, Amsterdam, The Netherlands.
Gerretsen
M
M
De Bree
R
R
Brakenhof
R
R
Van Dongen
G
G
Snow
G
G
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D002450:Cell Communication / Q000276:immunology; D002985:Clinical Protocols; D005544:Forecasting; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D051379:Mice; D008819:Mice, Nude; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm