Production of additional squalestatin analogues by directed biosynthesis.
Cannell
R J
RJ
Department of Natural Products Discovery, Glaxo Group Research Ltd., Greenford, Middlesex, U.K.
Dawson
M J
MJ
Hale
R S
RS
Hall
R M
RM
Noble
D
D
Lynn
S
S
Taylor
N L
NL
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002851:Chromatography, High Pressure Liquid; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D005285:Fermentation; D051381:Rats; D014233:Tricarboxylic Acids / Q000302:isolation & purification* / Q000494:pharmacology*
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D014233:Tricarboxylic Acids; C075117:squalestatin 1; D013186:Farnesyl-Diphosphate Farnesyltransferase