[The characteristics of the pharmacological action of buspirone].
Some aspects of the anxiolytic action of buspirone were investigated by differentiating fear from anxiety. Buspirone showing anxiolytic and antineurotic action in the models of anxiety and conflicting situation was demonstrated to be inactive in the model of fear of falling down from the elevated cross-shaped labyrinth. The antiamnestic effect of buspirone was revealed in the electroshock amnesia model. It is assumed that serotonin receptors are possibly responsible both for the anxiety and for memory processes.
Dzhagatspanian
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IA
Asrian
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AB
D000818:Animals; D001007:Anxiety / Q000188:drug therapy; D002065:Buspirone / Q000494:pharmacology* / Q000627:therapeutic use; D003214:Conditioning, Classical / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D005239:Fear / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D051381:Rats; D013469:Sulpiride / Q000494:pharmacology
D013469:Sulpiride; D003975:Diazepam; D002065:Buspirone
Nekotorye osobennosti farmakologicheskogo deĭstviia buspirona.