Effects of 2-buten-4-olide, an endogenous satiety substance, on plasma glucose, corticosterone, and catecholamines.
Effects of 2-buten-4-olide (2-B4O), an endogenous satiety substance, on levels of plasma glucose, corticosterone, and catecholamines were examined in fed, conscious, and unrestrained rats. A vascular indwelling catheter was inserted into the right atrium of the animal from the jugular vein 1 wk before the experiment. Injection of 2-B4O and blood sampling were performed through the catheter in an unanesthetized condition. The levels of plasma glucose, corticosterone, epinephrine, and norepinephrine increased significantly for 2 h after the start of intravenous injection of 2-B4O in a dose-dependent manner. The increases in glucose and catecholamines induced by 2-B4O injection were abolished by bilateral splanchnicotomy (SPX) but not by pretreatment with anti-corticotropin-releasing factor (CRF) antibody. The increase in corticosterone was abolished not by the SPX but by pretreatment with anti-CRF antibody. These findings suggest that 2-B4O, endogenously produced during food deprivation, may facilitate sympathoadrenal and hypothalamopituitary-adrenal functions through the central nervous system.
Matsumoto
I
I
Department of Physiology, Nagasaki University School of Medicine, Nagasaki, Japan.
Oomura
Y
Y
Nishino
H
H
Nemoto
S
S
Aou
S
S
Aikawa
T
T
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000097:blood*; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D012527:Satiation / Q000502:physiology*; D013997:Time Factors
D001786:Blood Glucose; D005663:Furans; C004511:butenolide; D015107:4-Butyrolactone; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine