Prognostic significance of estrogen receptor expression in ovarian cancer. Immunoreactive Score (IRS) vs. Composition Adjusted Receptor Level (CARL).
An Immunoreactive Score (IRS) was compared to the Composition Adjusted Receptor Level (CARL) evaluating prognostic significance of estrogen receptor (ER) expression in 61 ovarian cancers after > or = 8 years. CARL of ER allowed for calculating individual risk curves in stage III and IV, Grade 2 and 3, serous ovarian carcinoma after surgical debulking to < or = 2 cm residual and platinum based chemotherapy. In overall analysis and in subsets defined by tumor stage, grade or a combination thereof significant prognostic distinction became possible using a cutoff IRS of 4 vs. 0 or vs. scores < or = 3. This study substantiates ER as a prognostic variable in human ovarian cancer and for the first time establishes the value of an IRS.
Kieback
D G
DG
Department of Obstetrics & Gynecology, University of Ulm, Germany.
Press
M F
MF
Atkinson
E N
EN
Edwards
G L
GL
Möbus
V J
VJ
Runnebaum
I B
IB
Kreienberg
R
R
Jones
L A
LA
D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D016019:Survival Analysis
D011960:Receptors, Estrogen