title: Antitumour activity of coumarin in prostate and mammary cancer models.
abstract: The antineoplastic and antimetastatic activities of coumarin were evaluated in transplanted prostate tumours of the rat. The growth of Noble Nb-R prostate tumours was strongly inhibited by coumarin (40 mg/kg; administered three times per week), whereas the hormonally more sensitive Dunning R3327-G rat prostate carcinoma did not respond. Coumarin was also shown to possess antimetastatic activity in a Dunning R3327-MatLu tumour model. The number of lung metastases was reduced significantly by 40%-50% following the administration of coumarin (40 mg daily). Preliminary data from experiments with rats bearing DMBA-induced mammary carcinomas showed that these tumours are as sensitive to coumarin as Noble-R-prostate tumours.
authors.affiliation: Universität Regensburg, Institut für Pharmazie, Germany.
authors.forename: E
authors.initials: E
authors.lastname: von Angerer
authors.forename: M
authors.initials: M
authors.lastname: Kager
authors.forename: A
authors.initials: A
authors.lastname: Maucher
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D003374:Coumarins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats
chemical_list: D003374:Coumarins; C030123:coumarin