title: Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans.
abstract: The effect of rice bran oil, and oil not commonly consumed in the United States, on plasma lipid and apolipoprotein concentrations was studied within the context of a National Cholesterol Education Panel (NCEP) Step 2 diet and compared with the effects of canola, corn, and olive oils. The study subjects were 15 middle-aged and elderly subjects (8 postmenopausal women and 7 men; age range, 44 to 78 years) with elevated low-density lipoprotein (LDL) cholesterol (C) concentrations (range, 133 to 219 mg/dL). Diets enriched in each of the test oils were consumed by each subject for 32-day periods in a double-blind fashion and were ordered in a Latin square design. All food and drink were provided by the metabolic research unit. Diet components were identical (17% of calories as protein, 53% as carbohydrate, 30% as fat [< 7% as saturated fat], and 80 mg cholesterol/1000 kcal) except that two thirds of the fat in each diet was contributed by rice bran, canola, corn, or olive oil. Mean +/- SD plasma total cholesterol concentrations were 192 +/- 19, 194 +/- 20, 194 +/- 19, and 205 +/- 19 mg/dL, and LDL-C concentrations were 109 +/- 30, 109 +/- 26, 108 +/- 31, and 112 +/- 29 mg/dL after consumption of the rice bran, canola, corn, and olive oil-enriched diets, respectively. Plasma cholesterol and LDL-C concentrations were similar and statistically indistinguishable when the subjects consumed the rice bran, canola, and corn oil-enriched diets and lower than when they consumed the olive oil-enriched diet.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Lipid Metabolism Laboratory, HNRC/Tufts University, Boston, MA 02111.
authors.forename: A H
authors.initials: AH
authors.lastname: Lichtenstein
authors.forename: L M
authors.initials: LM
authors.lastname: Ausman
authors.forename: W
authors.initials: W
authors.lastname: Carrasco
authors.forename: L J
authors.initials: LJ
authors.lastname: Gualtieri
authors.forename: J L
authors.initials: JL
authors.lastname: Jenner
authors.forename: J M
authors.initials: JM
authors.lastname: Ordovas
authors.forename: R J
authors.initials: RJ
authors.lastname: Nicolosi
authors.forename: B R
authors.initials: BR
authors.lastname: Goldin
authors.forename: E J
authors.initials: EJ
authors.lastname: Schaefer
mesh_terms: D000328:Adult; D000368:Aged; D003314:Corn Oil / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004311:Double-Blind Method; D005227:Fatty Acids / Q000737:chemistry; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D012275:Oryza; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D000074262:Rapeseed Oil
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; D000074262:Rapeseed Oil; D003314:Corn Oil