Specificity of leukocyte-endothelial interactions and diapedesis: physiologic and therapeutic implications of an active decision process.
In situ studies have revealed that an active multistep process regulates leukocyte-endothelial cell recognition and diapedesis in vivo. The requirement for sequential engagement of receptors mediating transient adhesion, leukocyte activation, activation-dependent sticking and diapedesis implies that leukocyte recruitment can be regulated at any of these 4 steps, and provides a combinatorial mechanism to explain the remarkable specificity and diversity of leukocyte homing events in vivo. The model will help direct therapeutic approaches to controlling leukocyte traffic.
Butcher
E C
EC
Department of Pathology, Stanford University School of Medicine, CA 94305.
D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D008954:Models, Biological; D009504:Neutrophils / Q000502:physiology*
D015815:Cell Adhesion Molecules