[Cultivation of cicatricial fibroblasts and kinetics of growth].
The fibroblasts from normal skin, hypertrophic scar and keloid were cultured in vitro and their growth property was compared. The results showed that there was similar density-dependent inhibition in these three strains, and there were no morphological differences among them. But, in normal skin, fibroblasts were parallelly arranged, showing "fingerprint" and marked polarization, while that in hypertrophic scar and keloid presented crisscross and overlapping with less polarization. All of three strains had same growth kinetics, i.e. the cell growth curve, DNA synthesis and mitosis index were similar during their logarithmic phase.
Shang
Q X
QX
Department of Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai Second Medical University.
D000328:Adult; D002455:Cell Division; D002478:Cells, Cultured; D017439:Cicatrix, Hypertrophic / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007627:Keloid / Q000473:pathology*; D008297:Male; D012867:Skin / Q000166:cytology*