Migraine: possible role of platelet insensitivity to prostaglandin E1 (PGE1).
Platelet aggregation inhibition, induced by prostaglandin E1 (PGE1), was evaluated in 38 patients affected by migraine. Our data indicate a complete insensitivity to PGE1 in these subjects. The insensitivity to PGE1 leads to decreased cyclic-AMP (cAMP) levels, determining an imbalance in the inhibitory mechanism. From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.
Cerneca
F
F
Clinical Pathology Laboratory Haemostasis Service, Pediatric Hospital Burlo Garofolo, Trieste, Italy.
de Luyk
S
S
Radillo
O
O
Simeone
R
R
Mangiarotti
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000494:pharmacology* / Q000502:physiology; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002648:Child; D000242:Cyclic AMP / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values
D000244:Adenosine Diphosphate; D000242:Cyclic AMP; D000527:Alprostadil