[The morphofunctional instability of the lymphocyte membrane in patients with chronic kidney failure].
T-lymphocyte E-receptor activity, mobility of the surface and deep parts of lymphocytic membrane lipid bilayer and membrane transport function were studied in 47 patients with chronic renal failure (16 had a conservatively curable and 31 terminal stages). A rosette test, polarization of the fluorescent probes I-anilino-naphthaleno-8-sulfonate and pyrene, inclusion of 14C-uridine into immunocompetent cells were employed, respectively. The investigations demonstrate morphofunctional instability of the lymphocytic membranes as indicated by shifts in RFC E-receptor activity, in reduced microviscosity of the lipid bilayer and transport dysfunction. The disturbances progress with deterioration of renal function with their peak at the terminal stage of the disease. It is suggested that morphofunctional damage to the lymphocyte membranes cause, among other factors, lymphocytopenia and secondary immunodeficiency in chronic renal failure.
Grinshteĭn
Iu I
IuI
Osetrov
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Tereshchenko
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D002462:Cell Membrane / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000276:immunology*; D008231:Lymphopenia / Q000209:etiology / Q000276:immunology; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; C032193:glycoprotein receptor GPIb-IX
Morfofunktsional'naia nestabil'nost' membrany limfotsitov u bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu.