title: Nomograms of fetal nuchal fold thickness for early detection of Down syndrome.
abstract: A prospective study was undertaken in North India to find the normative data on the nuchal fold thickness of randomly selected 150 fetuses between 16-22nd week of gestation. The data revealed that the width of nuchal fold thickness ranged between 2-5 mm. The mean for 16-18, > 18-20, and > 20-22 week's gestation was 2.6 +/- 0.2, 3.8 +/- 0.9, and 4.0 +/- 0.8 mm respectively. In one fetus nuchal fold thickness was 6mm at 18 weeks (> 2SD above the normal value) and thus Down Syndrome was suspected. This was later confirmed by amniocentesis and karyotyping.
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi.
authors.forename: K
authors.initials: K
authors.lastname: Buckshee
authors.forename: K K
authors.initials: KK
authors.lastname: Roy
authors.forename: I C
authors.initials: IC
authors.lastname: Verma
mesh_terms: D004314:Down Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D005333:Fetus / Q000033:anatomy & histology*; D006801:Humans; D009333:Neck / Q000000981:diagnostic imaging / Q000196:embryology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012016:Reference Values; D016216:Ultrasonography, Prenatal