Adriamycin, cyclophosphamide and vindesine (ACV) versus mitoxantrone, cyclophosphamide and vindesine (NCV) in advanced breast cancer.
The choice of chemotherapy for advanced breast cancer patients is based on both response rates and anticipated side effects. Two polychemotherapy regimens, ACV and NCV, were compared in an open study with 90 patients of whom 69 were evaluable both for efficacy and toxicity. Both ACV and NCV are active in metastatic breast cancer. ACV leads to more remissions in a relatively short time. NCV treatment results in a larger proportion of stable diseases. ACV causes more important alopecia, nausea and vomiting. NCV gives more anemia. The characteristics of both treatment results give the oncologist the opportunity to choose in particular clinical situations.
Janssens
J P
JP
Limburgs Oncologisch Centrum, Hasselt-Genk, Belgium.
Chin
Y
Y
Deleu
M
M
Bonte
J
J
Staelens
Y
Y
D000328:Adult; D000368:Aged; D000505:Alopecia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D009422:Nervous System Diseases / Q000139:chemically induced; D013922:Thrombocytosis / Q000139:chemically induced; D014751:Vindesine / Q000008:administration & dosage
D004317:Doxorubicin; D003520:Cyclophosphamide; D008942:Mitoxantrone; D014751:Vindesine