Immunophenotyping of acute lymphoblastic leukaemia in Madras, India.
At the Cancer Institute, Madras, India, we have performed immunophenotyping in 125 untreated cases of acute lymphoblastic leukaemia using a panel of 16 monoclonal antibodies and the avidin-biotin immunoperoxidase technique in a haematology autoanalyser (Technicon Hi system). Our results demonstrate a marked difference in the phenotypic pattern of ALL compared to Western countries, the predominant finding being a relative excess of T-ALL and a paucity of C-ALL cases. Age distribution of C-ALL reveals a peak at 2-6 years in paediatric ALL cases.
Rajalekshmy
K R
KR
Haematology/Immunology Division, Cancer Institute, Adyar, Madras, South India.
Abitha
A R
AR
Pramila
R
R
Gnanasagar
T
T
Maitreyan
V
V
Shanta
V
V
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001322:Autoanalysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000276:immunology; D017678:Sex Distribution; D012959:Socioeconomic Factors