title: Vigabatrin as an anticonvulsant against pentylenetetrazol seizures.
abstract: The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective. At both doses and both time spans of drug action, seizure latency was prolonged, compared to controls and VP group.
authors.affiliation: DETAM (Institute for Biological and Medical Research), Istanbul Faculty of Medicine, Capa, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Sayin
authors.forename: S
authors.initials: S
authors.lastname: Cengiz
authors.forename: T
authors.initials: T
authors.lastname: Altug
mesh_terms: D000614:Aminocaproates / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010433:Pentylenetetrazole; D012640:Seizures / Q000517:prevention & control*; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid
chemical_list: D000614:Aminocaproates; D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin; D010433:Pentylenetetrazole