title: Long-term function in the remote region after myocardial infarction: importance of significant coronary stenoses in the non-infarct-related artery.
abstract: BACKGROUND
  Left ventricular (LV) function is the most important determinant of outcome after a myocardial infarction. Global LV function after a myocardial infarction is affected not only by wall motion in the infarct zone but also by regional function in the contralateral territory. It was hypothesised that the presence of significant stenoses in coronary arteries supplying the contralateral territory might influence the ability of this region to compensate for damaged myocardium after a myocardial infarction.
  
  
  RESULTS
  79 patients treated with thrombolysis for acute myocardial infarction had coronary and ventricular angiograms within 24 h and at a mean follow up of 12 months after myocardial infarction. Wall motion in the contralateral territory was analysed and scored by the centre line method and the change over time was correlated with the presence or absence of significant (> 70%) diameter stenoses in the non-infarct-related artery. Mean (SD) contralateral territory motion worsened, from 0.74 (1.78) to -1.55 (2.06) SD chord (p < 0.001) in 40 patients with stenoses, whereas contralateral territory motion improved from -0.02 (2.4) to 0.63 (2.21) SD chord (p < 0.05) in the 39 patients without coronary stenoses. The same pattern was present whether or not the infarct artery was patent. The global left ventricular ejection fraction at 12 months was also related to contralateral territory motion (r = 0.71, p < 0.001) and to the presence of coronary stenoses (54 (15)% in those with coronary stenoses and 62 (16)% in those without, p < 0.05).
  
  
  CONCLUSIONS
  The results demonstrate that significant stenoses in arteries supplying the non-infarct territory adversely affect global and regional left ventricular function after a transmural infarction. Non-infarct artery anatomy should be considered in intervention strategies to improve left ventricular function after acute myocardial infarction.
authors.affiliation: Heart Institute, University of São Paulo, Brazil.
authors.forename: C P
authors.initials: CP
authors.lastname: de Albuquerque
authors.forename: R
authors.initials: R
authors.lastname: Kalil-Filho
authors.forename: G
authors.initials: G
authors.lastname: Gerstenblith
authors.forename: O
authors.initials: O
authors.lastname: Nakano
authors.forename: V
authors.initials: V
authors.lastname: Barbosa
authors.forename: G
authors.initials: G
authors.lastname: Bellotti
authors.forename: F
authors.initials: F
authors.lastname: Pileggi
authors.forename: B
authors.initials: B
authors.lastname: Tranchesi
mesh_terms: D017023:Coronary Angiography; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D015912:Thrombolytic Therapy; D016277:Ventricular Function, Left / Q000502:physiology*