Carbonic anhydrase activators. VII. Isozyme II activation by bisazolyl-methanes, -ethanes and related azoles.
A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
Supuran
C T
CT
University of Bucharest, Department of Chemistry, Roumania.
Balaban
A T
AT
Cabildo
P
P
Claramunt
R M
RM
Lavandera
J L
JL
Elguero
J
J
D001393:Azoles / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004789:Enzyme Activation; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics
D001393:Azoles; D007527:Isoenzymes; D002256:Carbonic Anhydrases