Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father. A case report.
We report a case of neonatal allo-immune thrombocytopenia due to fetomaternal human platelet antigen (HPA)-1 incompatibility. Anit-HPA-1b antibodies were detectable in maternal serum. Repeated treatment of the infant with high-dose IgG effectively raised platelet counts transiently, but the patient remained thrombocytopenic for more than 6 weeks. Serological and DNA analysis revealed that the mother was homozygous HPA-1a and the father homozygous HPA-1b.
Moser
R
R
Department of Paediatrics, Krankenhaus Loeben, Austria.
Fae
I
I
Neumeister
A
A
Pober
M
M
Mutz
I
I
Panzer
S
S
D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology*; D005260:Female; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D010976:Platelet Count; D011247:Pregnancy; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000276:immunology*
D016824:Antigens, Human Platelet; D007518:Isoantibodies