title: [Acebutolol in the therapy of mild and moderate hypertension].
abstract: Acebutolol (sectral) is one of the new types of cardioselective beta-blockers which has at the same time also qualities of ISA. The author made a 6-month clinical study comprising 20 patients, focused on the antihypertensive effectiveness and tolerance of the drug. Administration of acebutolol led already after two weeks to a significant effect on the systolic and diastolic blood pressure and during the period of 1-6-month administration the maximal antihypertensive effect was achieved (-29 mm Hg systolic BP, -19 mm Hg diastolic BP). 24-hour monitoring of the BP proved antihypertensive effectiveness of acebutolol regardless whether the drug was administered in two daily doses or only once a day. In the course of the investigation no negative metabolic effects of acebutolol were observed.
authors.affiliation: III. interní klinika 1. LF UK Praha.
authors.forename: J
authors.initials: J
authors.lastname: Widimský
mesh_terms: D000070:Acebutolol / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D000070:Acebutolol
vernacular_title: Acebutolol v terapii mírné az strední hypertenze.