title: Synthesis, spectroscopic and structural characterization, and biological activity of aquachloro (pyridoxal thiosemicarbazone) copper(II) chloride.
abstract: The synthesis, spectroscopic studies, x-ray crystal structure, and biological properties of the complex [Cu(H2L)(OH2)Cl]Cl (1) (H2L = pyridoxal thiosemicarbazone) are reported. The compound crystallizes in space group P2(1)/n, a = 12.128(2), b = 9.096(2), c = 13.592(2) A, beta = 108.65(2) degrees, U = 1420.7 A3, and Z = 4. The molecular structure consists of discrete cations [Cu(H2L)(OH2)Cl]+ and Cl- anions. Each copper atom is in an approximately square pyramidal environment involving the phenolic oxygen, the imine nitrogen, the sulphur, and a water oxygen in the equatorial positions, while a chlorine atom occupies the axial position. The structure of this complex is compared to that of the dimeric [(Cu(HL)(OH2))2]Cl2.2H2O (2) obtained under different experimental conditions, to that of a Co(III) complex with the same ligand [Co(HL)L].4.5H2O (3) and to that of the free ligand H2L, especially in relation to its biological activity. Compounds 1 and 2 have not antiviral action in vitro with respect to RNA viruses, show an inductive effect on Friend erythroleukemia cells (FLC), erythroid differentiation and a suppressive effect regarding FLC proliferation. Complex 3 and the free ligand do not have biological activity.
authors.affiliation: Istituto di Chimica Generale ed Inorganica, Centro di Studio per la Strutturistica Diffrattometrica del C.N.R., Parma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Belicchi Ferrari
authors.forename: G
authors.initials: G
authors.lastname: Gasparri Fava
authors.forename: P
authors.initials: P
authors.lastname: Tarasconi
authors.forename: R
authors.initials: R
authors.lastname: Albertini
authors.forename: S
authors.initials: S
authors.lastname: Pinelli
authors.forename: R
authors.initials: R
authors.lastname: Starcich
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003460:Crystallization; D018360:Crystallography, X-Ray; D004247:DNA / Q000096:biosynthesis; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D046911:Macromolecular Substances; D051379:Mice; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012328:RNA Viruses / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D046911:Macromolecular Substances; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C086284:aquachloro(pyridoxal thiosemicarbazone)copper(II) chloride; D004247:DNA