title: Relationship between serum cyclo(His-Pro) concentrations and the nutritional status of HIV-infected patients.
abstract: Cyclo(His-Pro) (CHP) is a gut-neuropeptide that influences both appetite and carbohydrate metabolism. This study was undertaken to determine whether concentrations of CHP correlated with various clinical markers of nutritional status and progression of HIV infection. Serum concentrations of CHP were analyzed in a clinical sample of 100 HIV-positive patients whose HIV clinical status ranged from asymptomatic to advanced disease with weight loss. We found a relationship between CHP concentrations and serum albumin and hemoglobin levels, markers of chronic nutrition and disease. However, no correlation was seen between CHP and cortisol concentrations, a marker of acute stress. To analyze the relationship of HIV clinical stage and CHP, patients were divided into three subgroups: asymptomatic, mildly symptomatic, and clear-cut AIDS. CHP concentrations were significantly correlated with HIV clinical stage. These data lead to the hypothesis that CHP is a marker of disease progression and that it potentially plays a role in modulating the nutrition of HIV-infected patients.
authors.affiliation: Obesity Research Program, Louisiana State University Medical Center, School of Medicine, New Orleans.
authors.forename: T L
authors.initials: TL
authors.lastname: Wisniewski
authors.forename: E
authors.initials: E
authors.lastname: Mendel
authors.forename: E V
authors.initials: EV
authors.lastname: Morse
authors.forename: C W
authors.initials: CW
authors.lastname: Hilton
authors.forename: F
authors.initials: F
authors.lastname: Svec
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D006679:HIV Seropositivity / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D009752:Nutritional Status; D010456:Peptides, Cyclic / Q000097:blood*; D010879:Piperazines / Q000097:blood*; D012514:Sarcoma, Kaposi / Q000097:blood; D012709:Serum Albumin / Q000032:analysis
chemical_list: D006454:Hemoglobins; D010456:Peptides, Cyclic; D010879:Piperazines; D012709:Serum Albumin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; C015924:histidyl-proline diketopiperazine; D006854:Hydrocortisone