title: Spontaneous bile reflux in the elderly.
abstract: Duodenogastric bile reflux is common in postoperative stomach but has been reported in intact stomachs. Spontaneous bile reflux in the elderly has not been studied before. This has been assessed in dyspeptic elderly and young patients. Total bile acid (TBA) levels and pH were measured in the samples of fasting gastric juice. Antral biopsies were taken for histological examination including Helicobacter pylori identification. TBA levels were significantly higher in elderly patients with gastritis in comparison to elderly and young normal groups. Only 10% of elderly patients with gastritis and 7% with gastric ulcer has abnormal TBA (> 1 mmol/l). There was some correlation between the pH and TBA but a significant proportion of elderly patients has pH > 4 with a normal TBA. TBA levels were not significantly different in H. pylori +ve and H. pylori -ve patients. Nineteen elderly patients had evidence of reactive gastritis. Five of these patients had raised TBA levels with severe H. pylori infection. The remaining 15 patients had normal TBA. These patients were on NSAIDs and 4 of them had H. pylori infection. We conclude that spontaneous bile reflux in the elderly is uncommon. Hypochlorhydria which is observed in the elderly is not caused by alkaline bile reflux. The main cause of reactive gastritis in the elderly is NSAIDs ingestion.
authors.affiliation: Department of Medicine, Bristol Royal Infirmary, UK.
authors.forename: A F
authors.initials: AF
authors.lastname: Safe
authors.forename: O M
authors.initials: OM
authors.lastname: Nwose
authors.forename: L
authors.initials: L
authors.lastname: Sheehan
authors.forename: R A
authors.initials: RA
authors.lastname: Mountford
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001647:Bile Acids and Salts / Q000378:metabolism; D001655:Bile Reflux / Q000150:complications / Q000209:etiology* / Q000378:metabolism; D005756:Gastritis / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001647:Bile Acids and Salts