Carbohydrate metabolism studies after one year of using an oral contraceptive containing gestodene and ethinyl estradiol.
The objective of the study is to evaluate the effects of a gestodene-containing oral contraceptive on carbohydrate metabolism. The design of the study is prospective. The setting is at University of South Florida Outpatient Unit. The patients consisted of twenty-three normal women desiring contraception. Serum glucose and insulin levels were measured during a three-hour glucose tolerance test at control time and after one year of drug use.


RESULTS
All of the one-year glucose values were significantly elevated as well as the fasting and three-hour insulin values. These changes were mostly confined to women over 26 years of age and not in the younger 18 to 23 year olds. An oral contraceptive containing 75 micrograms of gestodene and 30 micrograms of ethinylestradiol can significantly alter carbohydrate metabolism in older women.
Spellacy
W N
WN
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33606.
Tsibris
A M
AM
Tsibris
J C
JC
George
S
S
Chez
R A
RA
O'Brien
W F
WF
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D015999:Multivariate Analysis; D009652:Norpregnenes / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies
D001786:Blood Glucose; D003276:Contraceptives, Oral; D007328:Insulin; D009652:Norpregnenes; C033273:Gestodene; D004997:Ethinyl Estradiol