The wound healing response to grafted tissues.
When a tissue graft is introduced into a healing wound, the inflammatory and proliferative stages of wound healing are significantly prolonged. This sustained stimulation at the surrounding graft site can develop into chronic inflammation, leading to fibrosis and connective tissue build-up around the graft. Persistence in chronic inflammation surrounding a tissue graft can lead to graft destruction or rejection. Thus, a basic understanding of soft-tissue wound healing in response to grafted tissue is important to optimize the long-term functional results of tissue grafts.
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University of Minnesota School of Medicine, Minneapolis.
D000273:Adipose Tissue / Q000637:transplantation; D002356:Cartilage / Q000637:transplantation; D006801:Humans; D012867:Skin / Q000528:radiation effects; D012879:Skin Physiological Phenomena; D016038:Skin Transplantation / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*