title: [Clinical evaluation of aciclovir granules in the treatment of chickenpox in otherwise healthy children].
abstract: The efficacy and safety of aciclovir granules (containing 40% w/w aciclovir) were evaluated in the treatment of chickenpox in otherwise healthy children. Patients presenting with chickenpox received aciclovir granules at a dose of 20 mg/kg four times daily for five to seven days. Overall 51 children received treatment with aciclovir. A further 53 patients receiving conventional symptomatic therapy acted as a control. In the aciclovir group the overall efficacy rate was 92.2%. There were reductions in the numbers of lesions, fever, itching and the duration of symptoms. No adverse experiences were reported. Overall this formulation of aciclovir appears to be a safe and effective treatment for chickenpox in this patient population. However the need for anti-viral therapy in otherwise healthy children is still the subject of debate and it might be appropriate to identify sub-groups for whom such therapy is justified.
authors.affiliation: Department of Pediatrics, Mie Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Kamiya
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
authors.forename: H
authors.initials: H
authors.lastname: Naruse
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Kajita
authors.forename: T
authors.initials: T
authors.lastname: Morishima
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: A
authors.initials: A
authors.lastname: Osuga
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D002644:Chickenpox / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D004304:Dosage Forms; D000212:Acyclovir