[Effects of the monosaccharide derivative 8RN-DAGal on the putative P-type calcium channel expressed in Xenopus oocytes].
P-type calcium channels are expressed in Xenopus oocytes after injection of rat cerebellar mRNA. The FTX and omega-Aga-IVa toxins extracted from Agelenopsis aperta venom are known to inhibit the activity of this channel. The present results demonstrate that 8RN-DAGal is also a antagonist of P-type calcium channels. The inhibition of the current, obtained with Ba2+, as charge carrier, is voltage dependent.
Fournier
F
F
Laboratoire de Neurobiologie Cellulaire, Université de Picardie Jules Verne, Faculté des Sciences, Amiens, France.
Charpentier
G
G
Lahyani
A
A
Bruner
J
J
Czternasty
G
G
Marlot
D
D
Ronco
G
G
Villa
P
P
Brule
G
G
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D005690:Galactose / Q000031:analogs & derivatives* / Q000494:pharmacology; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D014981:Xenopus
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D012333:RNA, Messenger; C086353:6-desoxy-6-n-octylamino-1,2-3,4-di-O-isopropylidenegalactopyranose; D005690:Galactose
Effets du dérivé monosaccharidique 8RN-DAGal sur un courant calcique apparenté au type P exprimé dans l'ovocyte de Xénope.