Turning behavior induced by intrastriatal injection of neurotensin in mice: sensitivity to non-peptide neurotensin antagonists.
The intrastriatal injection of neurotensin (10 pg/mouse) elicited vigorous contralateral rotations which were not affected by disruption of dopaminergic transmission using 6-OHDA lesion of the striatum or systemic administration of spiroperidol (0.03 mg/kg). SR 48692, a selective non-peptide antagonist of neurotensin receptor, produced the following pattern of changes: a significant antagonism of rotations was observed at 0.04 and 0.08 mg/kg i.p. followed by a reinstatement of rotations at 0.16-0.64 mg/kg (at higher doses, a second antagonism occurred that lacked stereoselectivity). The reinstatement of rotations observed at 0.16 and 0.32 mg/kg of SR 48692 was abolished by spiroperidol and 6-OHDA lesions, suggesting the role of dopamine regulatory mechanisms.
Poncelet
M
M
Sanofi Recherche, Neuropsychiatry Department, Montpellier, France.
Gueudet
C
C
Gully
D
D
Soubrié
P
P
Le Fur
G
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001927:Brain Diseases / Q000139:chemically induced; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004347:Drug Interactions; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D009496:Neurotensin / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D016627:Oxidopamine; D011720:Pyrazoles / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013134:Spiperone / Q000494:pharmacology
D011720:Pyrazoles; D011804:Quinolines; C086487:SR 48527; C079087:SR 48692; D009496:Neurotensin; D013134:Spiperone; D016627:Oxidopamine; D004298:Dopamine