N-myc expression in the embryonic cochlea of the mouse.
N-myc expression in the mouse embryo was examined during the late cochlear organogenesis. Tissue distribution of N-myc expression was histologically analyzed by in situ hybridization of the transcript in the cochlea between 15 and 18 days of gestation. At 15 days of gestation, N-myc expression was found very conspicuous in nervous structure of the cochlea such as the auditory nerve and the spiral ganglion. Moreover, N-myc was also present in the Köllikers organ and in the epithelium surrounding the cochlear canal. A few days later, N-myc expression was still clearly present in the Köllikers organ but less so in nervous structures. This study shows that cochlear tissues derived from the otic placode present a significant level of N-myc transcript during late embryogenesis. N-myc expression seems to be related to cell differentiation in the inner ear.
Romand
R
R
Laboratoire de Neurobiologie et Physiologie du développement, Université Blaise Pascal Clermont-II, Aubière, France.
Hirning-Folz
U
U
Ehret
G
G
D000818:Animals; D003051:Cochlea / Q000196:embryology* / Q000378:metabolism; D005629:Frozen Sections; D015870:Gene Expression; D016259:Genes, myc; D005865:Gestational Age; D017403:In Situ Hybridization; D051379:Mice; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000235:genetics*; D013136:Spiral Ganglion / Q000196:embryology / Q000378:metabolism; D014158:Transcription, Genetic; D000159:Vestibulocochlear Nerve / Q000196:embryology / Q000378:metabolism
D016271:Proto-Oncogene Proteins c-myc