p53 protein expression in squamocellular carcinomas of the lip.
Twenty-six cases of squamocellular carcinomas of the lip were immunostained for p53 protein. Nuclear accumulation of p53 protein was observed in 88% of the 26 carcinomas, in 64% of adjacent "normal" epithelium and in all four cases with adjacent atypical squamous epithelium. 93% of the specimens (13/14) with p53 protein accumulation in "normal" epithelium demonstrated evidence of solar elastosis. UV radiation may induce p53 gene mutation as an early event in the neoplastic transformation.
Berner
A
A
Department of Pathology, Norwegian Radium Hospital, Montebello, Oslo.
Holm
R
R
Naess
A
A
Hjortdal
O
O
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D002467:Cell Nucleus / Q000737:chemistry; D006801:Humans; D008048:Lip Neoplasms / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53