New cycloartanol sulfates from the alga Tydemania expeditionis: inhibitors of the protein tyrosine kinase pp60v-src.
Bioactivity-directed fractionation of the extracts of the green alga Tydemania expeditionis using the protein tyrosine kinase pp60v-src led to the isolation of three new cycloartanol disulfates, 1-3, which show modest inhibition of this enzyme. The structures were deduced by spectroscopic methods.
Govindan
M
M
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019.
Abbas
S A
SA
Schmitz
F J
FJ
Lee
R H
RH
Papkoff
J S
JS
Slate
D L
DL
D001358:Avian Sarcoma Viruses / Q000201:enzymology; D002478:Cells, Cultured; D000460:Chlorophyta / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015688:Oncogene Protein pp60(v-src) / Q000037:antagonists & inhibitors*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes
D010840:Phytosterols; D014315:Triterpenes; D015688:Oncogene Protein pp60(v-src); C100089:cycloartenol