A new synthesis of Rink's polymer, 4-(2',4'-dimethoxyphenylhydroxymethyl)phenoxymethylpolystyrene .
For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxbenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenozophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.
Váradi
G
G
Department of Medical Chemistry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Tóth
G K
GK
Penke
B
B
D000596:Amino Acids; D001894:Borohydrides / Q000737:chemistry; D002254:Carbonates; D005449:Fluorenes; D018020:Lithium Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D011137:Polystyrenes / Q000138:chemical synthesis*; D011188:Potassium; D012116:Resins, Plant / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
D000596:Amino Acids; D001894:Borohydrides; D002254:Carbonates; D005449:Fluorenes; D018020:Lithium Compounds; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D011137:Polystyrenes; D012116:Resins, Plant; C086438:Rink's polymer; C040936:lithium borohydride; C037593:potassium carbonate; D011188:Potassium