Glycemic thresholds for hypoglycemic responses in obese subjects.
The objective of this study was to compare glycemic thresholds for hypoglycemic responses in obese and control subjects. A modified glucose-clamp technique was used to produce a standardized fall in plasma glucose (0.5 mmol/l per 40 min) in nine morbidly obese and ten control subjects. The release of the counter-regulatory hormones was measured and a symptom questionnaire was filled out every 10 min. The hypoglycemic thresholds (taken as the plasma glucose level where the response exceeded the basal level +2 s.d.) were practically identical in the two groups both for the hormones and the symptoms (including hunger). Our results argue against the hypothesis that an increased sensitivity to a falling plasma glucose is of importance in the pathogenesis of obesity.
Vea
H
H
Department of Internal Medicine, University Hospital of Tromsø, Norway.
Jorde
R
R
Sager
G
G
Vaaler
S
S
Sundsfjord
J
J
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000150:complications; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications
D001786:Blood Glucose