title: Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease.
abstract: Controversial data have been reported with regard to the diagnostic value of the positron emission tomographic (PET) measurement of striatal glucose consumption (rCMRGlc) in chorea-free subjects at risk of Huntington's disease (HD). For further clarification of this issue we measured striatal and cerebellar rCMRGlc in 27 chorea-free subjects at risk of HD, 20 patients with manifest HD and 20 control subjects, using PET and 18F-fluorodeoxyglucose. In 6 of the at-risk subjects cerebellar ratios of striatal rCMRGlc were decreased below the corresponding 99% confidence limit determined in the controls. This indicates that the PET measurement of rCMRGlc may, indeed, be valuable in establishing the diagnosis of incipient HD in presymptomatic at-risk subjects.
authors.affiliation: Institute of Medicine, Research Center, KFA Jülich, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kuwert
authors.forename: H W
authors.initials: HW
authors.lastname: Lange
authors.forename: H
authors.initials: H
authors.lastname: Boecker
authors.forename: H
authors.initials: H
authors.lastname: Titz
authors.forename: H
authors.initials: H
authors.lastname: Herzog
authors.forename: A
authors.initials: A
authors.lastname: Aulich
authors.forename: B C
authors.initials: BC
authors.lastname: Wang
authors.forename: U
authors.initials: U
authors.lastname: Nayak
authors.forename: L E
authors.initials: LE
authors.lastname: Feinendegen
mesh_terms: D000293:Adolescent; D000328:Adult; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004198:Disease Susceptibility / Q000000981:diagnostic imaging; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D020022:Genetic Predisposition to Disease; D005947:Glucose / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D012306:Risk; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose