[Interconnection of poly-ADP-ribosylation of histones and NAD level in rat liver during repair of induced DNA damage].
The changes in the DNA single strands induced by MNU and the levels of poly(ADP)ribosylation of the histone fractions have been studied under conditions of increased NAD content in rat liver during the recovery incubation of tissue in Hank's solution at 37 degrees C. In the presence of high (in the physiological range) NAD concentrations the DNA repair was more active in comparison with the control. This process was accompanied by activation of poly(ADP)ribosylation of predominantly core histone fractions.
Vasil'eva
S M
SM
Muliavko
N A
NA
Donchenko
G V
GV
D000818:Animals; D004249:DNA Damage / Q000187:drug effects; D004260:DNA Repair; D006657:Histones / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity; D009243:NAD / Q000096:biosynthesis / Q000378:metabolism*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D051381:Rats
D006657:Histones; D009243:NAD; D011064:Poly Adenosine Diphosphate Ribose; D008770:Methylnitrosourea
Vzaimosviaz' poli-ADP-ribozilirovaniia gistonov i soderzhanie NAD v pecheni krys v protsesse reparatsii indutsirovannykh povrezhdeniĭ DNK.