title: Effect of balloon inflation in angiographically normal coronary segments during coronary angioscopy: a quantitative angiographic study.
abstract: Visualization of coronary stenoses by coronary angioscopy is facilitated by inflating an occlusive cuff located near the distal end of the device to temporarily interrupt blood flow. In animal models, this procedure induces substantial endothelial denudation. Experimental studies show that endothelial denudation may lead to neointimal hyperplasia at the denuded site. This study was designed to determine whether angioscopy was associated with significant changes in lumen diameter at the site of cuff inflation. We studied 52 consecutive patients undergoing coronary angioscopy. We measured with use of quantitative edge-detection angiography [computer-assisted evaluation of stenosis and restenosis (CAESAR) system] the mean and minimal lumen diameters at the site of cuff inflation localized by filming the inflated cuff during angioscopy and at control non-instrumented segments on angiograms performed before angioscopy, after angioscopy, and at 6 months follow-up. Follow-up angiograms were performed in 80% of eligible patients. At follow-up, the mean (3.22 +/- 0.54 mm) and minimal (2.76 +/- 0.58 mm) diameters of the segment exposed to the inflated cuff were not significantly different from the equivalent values (3.22 +/- 0.58 and 2.75 +/- 0.61 mm) before angioscopy. No significant changes occurred in the mean or minimal diameters of the control segments over the same period. The late change (follow-up minus pre-angioscopy) in mean lumen diameter at the cuff inflation site (-0.005 +/- 0.18 mm) was not significantly different from that at the control site (0.004 +/- 0.20 mm).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service de Cardiologie B et Hémodynamique, Hôpital Cardiologique, Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: J M
authors.initials: JM
authors.lastname: Lablanche
authors.forename: C
authors.initials: C
authors.lastname: Bauters
authors.forename: E P
authors.initials: EP
authors.lastname: McFadden
authors.forename: P
authors.initials: P
authors.lastname: Quandalle
authors.forename: M E
authors.initials: ME
authors.lastname: Bertrand
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D020677:Angioscopes; D017023:Coronary Angiography / Q000295:instrumentation*; D003327:Coronary Disease / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged