Bloodstream infections after interventional procedures in the biliary tract.
OBJECTIVE
To assess the adequacy of prophylaxis for interventional radiologic biliary procedures and the etiologic organisms of subsequent bloodstream infections.


METHODS
Data from 148 patients who underwent 480 interventional radiologic biliary procedures were evaluated for evidence of bloodstream infection. Data analyzed included type of procedure performed, whether an antibiotic was used, and evidence of infectious complications occurring during and within 72 hours after the procedure. All culture data obtained before and after the procedure were recorded.


RESULTS
Seven cases of new bloodstream infection were identified, five of which were caused by Enterococcus species. No substantial risk factors for bloodstream infection were identified, although it occurred only in patients who had recently undergone biliary surgery or underwent manipulations other than simple cholangiography. Microbial colonization of the bile was associated with older age. Evidence of possible or proved infection after the first interventional procedure was more common in patients with positive bile cultures.


CONCLUSIONS
Although the importance of enterococcal bacteremia is uncertain, current recommendations for cephalosporin prophylaxis for interventional radiologic biliary procedures should be reevaluated.
Clark
C D
CD
Department of Pharmacy, Indiana University Medical Center, Indianapolis, MO 63110.
Picus
D
D
Dunagan
W C
WC
D016470:Bacteremia / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D001646:Bile / Q000382:microbiology; D001659:Biliary Tract; D002511:Cephalosporins / Q000627:therapeutic use; D002758:Cholangiography / Q000009:adverse effects*; D016983:Enterococcus / Q000302:isolation & purification; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D015642:Radiology, Interventional; D012307:Risk Factors
D002511:Cephalosporins