Cerebrospinal fluid concentrations of caffeine following oral drug administration: correlation with salivary and plasma concentrations.
Twelve hospitalized adult patients received 300 mg of oral caffeine 1 h before a diagnostic lumbar puncture. Caffeine concentrations were determined simultaneously in saliva, plasma, and cerebrospinal fluid (CSF). Mean caffeine concentrations in plasma, saliva, and CSF were 5.9 +/- 2.1, 4.4 +/- 1.5, and 2.9 +/- 1.1 micrograms/ml, respectively, with coefficients of correlation plasma-saliva, saliva-CSF, and plasma-CSF of 0.89, 0.79, and 0.77, respectively, all statistically significant (p < 0.001).
Soto
J
J
Clinical Pharmacology Unit, Hospital Santa Cruz, Liencres-Cantabria, Spain.
Sacristan
J A
JA
Alsar
M J
MJ
D000368:Aged; D002110:Caffeine / Q000097:blood / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D002110:Caffeine