Low doses of interleukin-2 can cure large bovine ocular squamous cell carcinoma.
Four cows bearing large Ocular Squamous Cell Carcinomas (BOSCC) were treated by 10 intratumoral injections (Monday-Friday for 2 consecutive weeks) of 200,000 U Interleukin-2 (Cetus). Tumors regressed in 2 out of 4 cases. This result shows that even large tumors may regress after local IL-2 treatment.
Den Otter
W
W
Department of Pathology, Academical Hospital Utrecht, The Netherlands.
Hill
F W
FW
Klein
W R
WR
Koten
J W
JW
Steerenberg
P A
PA
De Mulder
P H
PH
Rutten
V P
VP
Ruitenberg
E J
EJ
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology / Q000628:therapy*; D005142:Eyelid Neoplasms / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000008:administration & dosage*
D007376:Interleukin-2