title: Selective radionuclide localisation in primary liver tumours (pilot study).
abstract: The therapeutic potential of 131I-Lipiodol was investigated in 8 patients with cholangiocarcinoma (CCA) and 15 patients with hepatocellular carcinoma (HCC). Patients received one or two doses of 131I-Lipiodol via hepatic arterial injection. The mean total administered activity was 668 (SD 325) MBq in CCA and 953 (SD 477) MBq in HCC. One patient with CCA retained 131I-Lipiodol. The cumulative radiation dose was 9.6 Gy to tumour, 6.4 Gy to liver and 1.5 Gy to lung. The patient remained asymptomatic with no evidence of tumour 30 months from the start of treatment, whereas the remaining 7 patients exhibited tumour progression. The mean survival in CCA was 11.6 (SD 14.5) months. All 15 patients with HCC retained 131I with tumour: liver ratios of up to 30:1. The mean cumulative radiation dose was 34.7 (SD 32.4) Gy to tumour, 3.3 (SD 1.5) Gy to liver and 4.4 (SD 2.3) Gy to lung. The mean dose per administered activity was 3.8 (SD 4.1) cGy/MBq. Partial response (reduction in tumour size > 50%) was observed in 6 patients (40%). The mean survival was 7.1 (SD 6.0) months. 131I-Lipiodol can deliver highly selective internal irradiation to foci of HCC with evidence of objective response and may be the treatment of choice for patients with cirrhosis and a small tumour.
authors.affiliation: University Dept of Surgery, Dept of Nuclear Medicine and Radiology, Clinical Oncology Unit, Royal Free Hospital, London, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Novell
authors.forename: A J
authors.initials: AJ
authors.lastname: Green
authors.forename: A J
authors.initials: AJ
authors.lastname: Hilson
authors.forename: G
authors.initials: G
authors.lastname: Dusheiko
authors.forename: R
authors.initials: R
authors.lastname: Dick
authors.forename: K E
authors.initials: KE
authors.lastname: Hobbs
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D015902:Gamma Cameras; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007459:Iodized Oil / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011877:Radionuclide Imaging; D012074:Remission Induction; D015996:Survival Rate; D013671:Technetium Tc 99m Sulfur Colloid; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid; D007459:Iodized Oil