Exclusion of two candidate loci for autosomal recessive nemaline myopathy.
The putative gene for autosomal recessive nemaline myopathy has not been mapped, cloned, or otherwise characterised. We used linkage analysis with polymorphic CA repeats to test for the involvement of two candidate loci, APOA2 and ACTN2. Based on the segregation in five families both candidate loci could be excluded.
Tahvanainen
E
E
Department of Medical Genetics, University of Helsinki, Finland.
Beggs
A H
AH
Wallgren-Pettersson
C
C
D000185:Actinin / Q000235:genetics*; D016633:Apolipoprotein A-II / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D017696:Myopathies, Nemaline / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic
D016633:Apolipoprotein A-II; D000185:Actinin