[Long-term treatment of sleep apnea with evening administration of oral retard theophylline].
In 776 patients suffering from sleep apnoea long-term treatment with sustained-release theophylline was investigated. Responders show a significant reduction of apnoea phases. Using an individual theophylline dosage with morning theophylline concentrations between 5 and 8 micrograms/ml, only few side effects occurred. Positive effects on cardiopulmonary capacity were seen.
Dorow
P
P
Abt. Pneumologie, DRK-Krankenhaus Mark Brandenburg, Akademisches Lehrkrankenhaus, Freien Universität Berlin.
Thalhofer
S
S
Heinemann
S
S
Meissner
P
P
Kühler
U
U
D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D017286:Polysomnography / Q000187:drug effects; D012891:Sleep Apnea Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects
D013806:Theophylline
Langzeitbehandlung der Schlafapnoe mit einer abendlichen Gabe von oralem retardierten Theophyllin.