title: Infiltration of eosinophils in Hodgkin's disease involved lymph nodes predicts prognosis.
abstract: The number of infiltrating eosinophils were counted in tumour specimens from an unselected material of 140 cases of primary Hodgkin's disease (HD) and divided in three groups. Twenty-six cases (19 per cent) showed heavy infiltration (> 200 eosinophils/10 vision fields (VF)), 51 (36 per cent) moderate infiltration (11-200 eosinophils/10 VF and 63 virtually no infiltration (< 10 eosinophils/10 VF). The eosinophilic infiltration was significantly more pronounced in the nodular sclerosis subtype. Cases with heavy infiltration had a significantly worse disease-free survival compared to other cases. In a multivariate analysis, heavy eosinophilic infiltration was the most important factor for determining disease-free survival in all patients and also when patients above and below 60 were analysed separately.
authors.affiliation: Department of Oncology, University of Uppsala, Akademiska sjukhuset, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Enblad
authors.forename: C
authors.initials: C
authors.lastname: Sundstrom
authors.forename: B
authors.initials: B
authors.lastname: Glimelius
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004804:Eosinophils / Q000473:pathology*; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate