Evidence for autosomal dominant transmission in Tourette's syndrome. United Kingdom cohort study.
Complex segregation analyses were performed on families ascertained through 40 unselected consecutive patients with Tourette's syndrome to examine the hypothesis that its transmission is consistent with genetic inheritance. Analyses were done using several diagnostic classifications. All results were consistent with an autosomal dominant gene with high penetrance. The penetrances ranged from 0.882 to 1.000 for males and 0.452 to 0.980 for females, depending upon the specific classification scheme incorporated into the analyses.
Eapen
V
V
National Hospital for Neurology and Neurosurgery, London.
Pauls
D L
DL
Robertson
M M
MM
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics; D015995:Prevalence; D012737:Sex Factors; D005879:Tourette Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*