title: Implications of upright gastro-oesophageal reflux.
abstract: The presentation, oesophageal profile and management of 27 symptomatic patients with daytime (upright) gastro-oesophageal reflux only is reported. Oesophagitis was a presenting feature in 11 patients and its development was most closely correlated with postprandial reflux, which was characterized by cumulative acid exposure rather than by clearance abnormalities. Upright reflux was not associated with a hypotensive lower oesophageal sphincter or with oesophageal dysmotility. Antireflux surgery is indicated when conservative measures fail and was not associated with gas-bloat syndrome after operation.
authors.affiliation: University Department of Surgery, Trinity College Medical School, St James's Hospital, Dublin, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: Gillen
authors.forename: J
authors.initials: J
authors.lastname: Thornton
authors.forename: P J
authors.initials: PJ
authors.lastname: Byrne
authors.forename: T N
authors.initials: TN
authors.lastname: Walsh
authors.forename: T P
authors.initials: TP
authors.lastname: Hennessy
mesh_terms: D000328:Adult; D000368:Aged; D016099:Endoscopy, Gastrointestinal; D004941:Esophagitis / Q000150:complications / Q000503:physiopathology; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011187:Posture; D011312:Pressure; D016896:Treatment Outcome