title: Knowledge-based protein modeling.
abstract: Knowledge, both from the three-dimensional structures of homologous proteins and from the general analysis of protein structure, is of value in modeling a protein of known sequence but unknown structure. While many models are still constructed at least in part by manual methods on graphics devices, automated procedures have come into greater use. These procedures include those that assemble fragments of structure from other known structures and those that derive coordinates for the model from the satisfaction of restraints placed on atomic positions.
authors.affiliation: Imperial Cancer Research Fund, Department of Crystallography, Birkbeck College, London.
authors.forename: M S
authors.initials: MS
authors.lastname: Johnson
authors.forename: N
authors.initials: N
authors.lastname: Srinivasan
authors.forename: R
authors.initials: R
authors.lastname: Sowdhamini
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D012984:Software
chemical_list: D011506:Proteins