title: Bleeding peptic ulcer: an audit of conservative management.
abstract: One hundred and twenty-six of 157 consecutive patients (80%) admitted for a bleeding peptic ulcer were treated conservatively and retrospectively analysed. There were 52% duodenal, 41% gastric and 7% combined ulcers. The initial shock index (pulse/systolic blood pressure) was in excess of one in 10%. For 22% of the patients no transfusion was required but 10% had more than 6 units of blood during their hospital stay. Forty-nine per cent were on nonsteroidal anti-inflammatory drugs and 83% had at least one coexisting systemic disease. Six patients (5%) had a further haemorrhage, four of whom died. A total of 10 patients (8%) died. Five of them were related to the peptic ulcer disease but also had terminal or multiple systemic diseases precluding any surgery. Their poor short-term prognosis shows how difficult it will be to effectively reduce the mortality in this particular group of conservatively treated patients, even with the recent advent of endoscopic haemostasis, and stresses the importance of carefully identifying high risk patients in trials mounted to improve on the current mortality figures.
authors.affiliation: Department Chirurgie, Kantonsspital Basel, Switzerland.
authors.forename: X
authors.initials: X
authors.lastname: Mueller
authors.forename: J M
authors.initials: JM
authors.lastname: Rothenbuehler
authors.forename: A
authors.initials: A
authors.lastname: Amery
authors.forename: F
authors.initials: F
authors.lastname: Harder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications*; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D011899:Ranitidine / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000150:complications*
chemical_list: D011899:Ranitidine