title: Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue.
abstract: A marijuana compound, cannabinol [1], was converted to two metabolites using in vitro tissue of Pinellia ternata. The structures of the metabolites were determined to be cannabinol-O-beta-D-glucopyranoside [2] and 9'-hydroxycannabinol-O-beta-D-glucopyranoside [3] by 1H nmr and 13C nmr. From the time course experiments, 1 was absorbed rapidly in the tissues and glycosylated. Hydroxylation at the pentyl group occurred, and its metabolite was secreted in the medium.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shoyama
mesh_terms: D001711:Biotransformation; D002187:Cannabinol / Q000737:chemistry / Q000493:pharmacokinetics*; D002188:Cannabis / Q000737:chemistry*; D002478:Cells, Cultured; D006027:Glycosides / Q000378:metabolism; D010944:Plants / Q000378:metabolism*
chemical_list: D006027:Glycosides; D002187:Cannabinol