[The reaction of rejection. Elements of diagnosis, surveillance, therapeutic attitude in cases of kidney grafts].
Allograft rejection reaction must be integrated within the general framework of alloreactivity, i.e. involving a huge T cell repertoire with a high number of alloreactive precursors. This reaction is modulated by the particular immunological state induced by chronic renal insufficiency, haemodialysis and primary kidney disease. The inefficiency of current immunosuppressive drugs is illustrated by the tendency towards chronic rejection, involving many growth factors. It must be noted that allo-stimulating cells are different from target cells. Therapeutical armamentarium currently involves corticosteroids and serotherapy, but it is hoped that new immunosuppressive drugs will increase the efficiency of rejection crisis treatment.
Deglise-Favre
A
A
Service de Néphrologie, Hôpital de Bicêtre, Kremlin-Bicêtre.
Charpentier
B
B
D000208:Acute Disease; D006084:Graft Rejection / Q000175:diagnosis* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D013997:Time Factors
D007166:Immunosuppressive Agents
La réaction de rejet. Eléments de diagnostic, de surveillance, attitude thérapeutique dans le cas du rein.