[Actions of new iminium compounds against bacteria and fungi. 30. 3-alkoxymethyl-1-hexyl-, 3-alkylthiomethyl-1-hexyl-, 3-alkoxymethyl-1-octyl- and 3-alkylthiomethyl-1-octylbenzimidazolium chlorides].
Syntheses and antimicrobial activity of the title compounds are described. They were obtained by reaction of 1-hexyl- or 1-octylbenzimidazol with chloromethylalkyl ether or chloromethylalkyl sulfide. The antibacterial properties were tested on 13 strains of bacteria and fungi. The best antibacterial activity was exhibited by chlorides with octylthiomethyl and decyloxymethyl groups.
Pernak
J
J
Institut für Chemische Technologie, Technischen Universität, Poznań, Polen.
Skrzypczak
A
A
Krysiński
J
J
Kaźmierczak
M
M
Jedraszczyk
J
J
Michalak
L
L
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001562:Benzimidazoles
Wirkung neuer Iminiumverbindungen gegen Bakterien und Pilze, 30. Mitt.: 3-Alkoxymethyl-1-hexyl-,3-Alkylthiomethyl-1-hexyl-, 3-Alkoxymethyl-1-oktyl- und 3-Alkylthiomethyl-1-oktylbenzimidazoliumchloride.