Systemic lupus erythematosus. Antibodies to ribonuclear proteins.
This review has emphasized that utility of measuring the autoimmune responses to several RNP antigens in the diagnosis of SLE, as well as their use in delineating clinical subsets. The future of this area lies in the definition of the pathogenetic mechanisms that link these autoimmune responses to clinical expression of disease.
Reichlin
M
M
Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City.
D000974:Antibodies, Antinuclear / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D020733:RNA, Small Cytoplasmic; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D017412:Ribonucleoprotein, U1 Small Nuclear; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human