title: Relationship of five anthropometric measurements at age 18 to radiation dose among atomic bomb survivors exposed in utero.
abstract: Five body measurements--standing height, body weight, sitting height, chest circumference and intercristal diameter--of 18-year-old atomic bomb survivors exposed in utero in Hiroshima and Nagasaki were analyzed in relation to DS86 uterine dose. Age in utero was divided into four periods: 0-7, 8-15, 16-25 and > or = 26 weeks. This categorization is based upon the study of radiation-induced brain damage. The linear regression analyses for these five variables showed significant decreases with increasing dose. The regression coefficients were -2.65 cm/Gy for standing height, -2.46 kg/Gy for body weight, -0.92 cm/Gy for sitting height, -1.37 cm/Gy for chest circumference and -0.32 cm/Gy for intercristal diameter. The multivariate test statistic for the overall dose effect on five body measurements was significant, but the interaction between dose and gestational period was not significant. Principal-component analysis was applied to the five variables. For the first-component scores, the dose effect was significant, but the interaction between dose and gestational period was not significant. For the second-component scores, the dose effect was significant specifically at 0-7 weeks. The radiation dose effect on the second principal component found at 0-7 weeks of gestation suggests that malformations occur in this period.
authors.affiliation: Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Nakashima
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000528:radiation effects; D001835:Body Weight / Q000528:radiation effects; D002648:Child; D004622:Embryo, Mammalian / Q000528:radiation effects*; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005865:Gestational Age; D006128:Growth / Q000528:radiation effects*; D006801:Humans; D007564:Japan; D008297:Male; D009689:Nuclear Warfare; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012044:Regression Analysis; D013534:Survival