[The effect of long-term probucol intake on the lipoprotein cholesterol content and glutathione peroxidase activity in the blood of patients with coronary arteriosclerosis and hyperlipidemia].
The authors present results of 6-month probucol (lipomal) therapy in patients with coronary heart disease concurrent with Types 2a and 2b hyperlipidemia. There were 22 and 23% increases in total cholesterol and low density lipoprotein cholesterol, respectively, whereas the levels of high density lipoprotein decreased and triglycerides remained unchanged. Having antioxidative properties, probucol enhanced the activity of the antioxidative enzyme glutathione peroxidase on an average twice, which should be borne in mind in evaluating the efficiency of treatment.
Lankin
V Z
VZ
Revenko
V M
VM
Lupanov
V P
VP
Tikhaze
A K
AK
Liakishev
A A
AA
Kukharchuk
V V
VV
D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects*; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011341:Probucol / Q000008:administration & dosage*; D013997:Time Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005979:Glutathione Peroxidase; D011341:Probucol
Vliianie dlitel'nogo priema probukola na soderzhanie kholesterina lipoproteidov i aktivnost' glutationperoksidazy v krovi bol'nykh koronarnym aterosklerozom s giperlipidemieĭ.