[Age factors in natural mechanisms of detoxication and curative effect of enterosgel in burns].
In the experiment, the age peculiarities of the detoxication system of the liver in burn disease and the effect of enterosgel on them were studied. Decrease in hydroxylase and demethylase activity of hepatic microsomes in relatively stable activity of oxidoreductase as well as increase in activity of aminotransferases, especially that of alanine aminotransferase, which was more pronounced in aged animals, was noted. Under the influence of enterosorption, the increase in functional activity of monooxygenase system of the liver and stabilization of hepatocytic membranes are more pronounced in young animals. This contributed to reduction in lethality, activation of natural mechanisms of detoxication and reparative processes.
Naĭda
I V
IV
Zapadniuk
V I
VI
Povstianoĭ
N E
NE
Bezverkhaia
I S
IS
Zaika
M U
MU
Oranskaia
S A
SA
Shevchenko
Iu N
IuN
D000367:Age Factors; D000410:Alanine Transaminase / Q000032:analysis; D000633:Aminopyrine N-Demethylase / Q000032:analysis; D000815:Aniline Hydroxylase / Q000032:analysis; D000818:Animals; D002056:Burns / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D002462:Cell Membrane; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D005782:Gels / Q000627:therapeutic use; D008111:Liver Function Tests; D008862:Microsomes, Liver / Q000201:enzymology / Q000648:ultrastructure; D010084:Oxidation-Reduction; D051381:Rats; D016060:Sorption Detoxification
D005782:Gels; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D000410:Alanine Transaminase
Vozrastnye osobennosti estestvennykh mekhanizmov detoksikatsii i lechebnoe deĭstvie énterosgelia pri ozhogovoĭ bolezni.