title: [Clinical significance of changes in plasma renin-angiotensin aldosterone system in patients with high altitude pulmonary edema].
abstract: Plasma levels of renin activity, angiotensin II and aldosterone were determined in 16 patients with high altitude pulmonary edema (HAPE) with radioimmunoassay and compared with those in the controls including 9 patients with high altitude acute response (HAAR) and 14 health subjects. All of them arrived recently in Lhasa, a place with an altitude of 3,658 m. The results showed that the concentration of plasma renin activity, angiotensin II, and aldosterone was significantly increased (P < 0.05-0.001) in patients with HAPE and higher than that in the controls. It is suggested that the increase plays a role in the development of pulmonary edema in patients with HAPE.
authors.affiliation: PLA General Hospital of Xi Zang, Lhasa.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.forename: D C
authors.initials: DC
authors.lastname: Luo
authors.forename: Q
authors.initials: Q
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000532:Altitude Sickness / Q000378:metabolism*; D000804:Angiotensin II / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000378:metabolism*; D011863:Radioimmunoassay; D012084:Renin-Angiotensin System
chemical_list: D000804:Angiotensin II