title: [The mechanisms of the hepatotoxicity of complex platinum compounds].
abstract: Cisplatin and platin given in LD50 to mice caused significant changes in hepatic metabolism. There was enhanced lipid peroxidation with accumulation of malonic dialdehyde, dienic conjugates, Schiff bases, decreased antiradical activity and alterations in the fractional composition of phospholipids with higher concentrations of membranotoxic ingredients. There was also an increase in the serum activity of transaminases and alkaline phosphatase.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Dubskaia
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000633:toxicity; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D017671:Platinum Compounds / Q000633:toxicity*; D013997:Time Factors
chemical_list: D017671:Platinum Compounds; D002945:Cisplatin
vernacular_title: Mekhanizmy gepatotoksichnosti kompleksnykh soedineniĭ platiny.