[Veno-occlusive disease after liver transplantation. Association of acute cellular rejection and toxicity of azathioprine].
Azathioprine vascular hepatotoxicity has been described mainly after renal transplantation. We report a new case in a patient who developed veno-occlusive disease of the liver 3 weeks after liver transplantation; regression of lesions were observed after discontinuation of azathioprine therapy. In this case, azathioprine hepatotoxicity may have been enhanced by a previous episode of severe, acute rejection prevailing in the hepatic veins. After liver transplantation, the diagnosis of azathioprine hepatotoxicity is difficult but should be suspected in the presence of non-inflammatory small hepatic veins lesions. Early withdrawal of the drug is mandatory for complete recovery.
Mion
F
F
Unité de Transplantation Hépatique, Hôpital Edouard-Herriot, Lyon.
Cloix
P
P
Boillot
O
O
Gille
D
D
Bouvier
R
R
Paliard
P
P
Berger
F
F
D000208:Acute Disease; D001379:Azathioprine / Q000633:toxicity*; D001706:Biopsy; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000150:complications* / Q000473:pathology; D006504:Hepatic Veno-Occlusive Disease / Q000097:blood / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
D001379:Azathioprine
Maladie veino-occlusive après transplantation hépatique. Association d'un rejet aigu cellulaire et de la toxicité de l'azathioprine.