Maternal vitamin D status has no effect on the ontogeny of calcium-binding proteins in the duodenum, kidney and cerebellum of fetal mice.
The effects of vitamin D3 deficiency on the ontogeny of calcium-binding proteins (CaBPs) and the vitamin D receptor in the duodenum, kidney and cerebellum of the mouse were examined. Maternal vitamin D status did not affect the time of appearance of the fetal 28 kDa CaBP (CaBP-D28k) in the cerebellum, kidney and duodenum, and the 9 kDa CaBP (CaBP-D9k) in the intestine and kidney. Vitamin D receptor was undetectable in all fetal tissues, regardless of maternal vitamin D status, at all stages of gestation examined. Thus it appears that maternal vitamin D status does not affect the ontogeny of CaBP-D9k or CaBP-D28k in the mouse fetus. The factors that influence the appearance of calbindins in the fetus are unclear.
Shamley
D R
DR
Department of Anatomy, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Buffenstein
R
R
Veale
G
G
Pettifor
J M
JM
D000818:Animals; D002531:Cerebellum / Q000196:embryology* / Q000378:metabolism; D002762:Cholecalciferol / Q000008:administration & dosage / Q000172:deficiency*; D004032:Diet; D004386:Duodenum / Q000196:embryology* / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D007668:Kidney / Q000196:embryology* / Q000378:metabolism; D008650:Mesonephros / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009752:Nutritional Status; D011247:Pregnancy; D011270:Pregnancy, Animal; D018167:Receptors, Calcitriol / Q000032:analysis; D064030:S100 Calcium Binding Protein G / Q000032:analysis / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000378:metabolism*
D018167:Receptors, Calcitriol; D064030:S100 Calcium Binding Protein G; D002762:Cholecalciferol