Subversion of host immune responses by viral superantigens.
Recent experiments with mouse mammary tumor virus indicate that expression of a virally encoded superantigen by B cells and its subsequent recognition by T cells are essential steps for amplification of infection and virus transmission. Preliminary results suggest that superantigens may also be expressed during retroviral infection in humans.
Acha-Orbea
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Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
MacDonald
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D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology; D008214:Lymphocytes / Q000382:microbiology; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology*; D051379:Mice; D012192:Retroviridae Infections / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology
D000956:Antigens, Viral; D018089:Superantigens