Ideal therapeutic range of cyclosporine in whole blood in kidney-transplanted patients.
Two hundred and eighty-seven renal-transplanted recipients treated with cyclosporine were monitored for their cyclosporine trough blood level periodically. Based on the monitor results, we now can define the ideal therapeutic range of cyclosporine in whole blood as follows: 500-600 ng/ml in the first week of post-transplantation, 600-800 ng/ml in the second week to sixth month of post-transplantation, 400-600 ng/ml in the seventh to twelfth month of post-transplantation and 350-400 ng/ml 1 year after post-transplantation.
Xu
F
F
Department of Clinical Pharmacology, Nanfang Hospital, Guangzhou, China.
Chen
Z L
ZL
Jin
W J
WJ
Xie
Q D
QD
Shi
X H
XH
D000293:Adolescent; D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D016572:Cyclosporine