Osteoporosis by ovariectomy: calcitonin effect in an experimental model on the rat.
The authors evaluate the efficacy of the aminosuberic derivative of eel calcitonin (eCT) in preventing post-ovariectomy osteoporosis in adult rats. The drug is administered in a dose of 0.5 U.I./day for four months starting from the moment of the ovariectomy. The results show that the treatment is efficacious in preventing bone mass loss due to ovariectomy and that the action of the drug does not bring about alterations in the normal crystalline structure of the bone.
Gnudi
S
S
Rizzoli Orthopaedic Institute, University of Bologna.
Giardino
R
R
Mongiorgi
R
R
Zati
A
A
Giavaresi
G L
GL
Bertocchi
G
G
Gandolfi
M G
MG
Avella
M
M
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002116:Calcitonin / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000737:chemistry; D008903:Minerals / Q000032:analysis; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D010052:Ovariectomy / Q000009:adverse effects*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley
D008903:Minerals; D010281:Parathyroid Hormone; D015675:Osteocalcin; D010758:Phosphorus; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium