title: In vitro antifungal activity of triterpenoid saponins.
abstract: The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. alpha-Hederin was the most active compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.
authors.affiliation: Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Favel
authors.forename: M D
authors.initials: MD
authors.lastname: Steinmetz
authors.forename: P
authors.initials: P
authors.lastname: Regli
authors.forename: E
authors.initials: E
authors.lastname: Vidal-Ollivier
authors.forename: R
authors.initials: R
authors.lastname: Elias
authors.forename: G
authors.initials: G
authors.lastname: Balansard
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D010944:Plants / Q000737:chemistry; D012503:Saponins / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D012503:Saponins; D014315:Triterpenes