Synthesis, toxicity and immunomodulating activity of Co(II), Ni(II), Cu(II) and Zn(II) complexes of L(-)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole (levamisole).
Co(II), Ni(II), Cu(II) and Zn(II) complexes of levamisole (LMS) were prepared and characterized by elemental analyses, IR spectroscopy, 1H and 13C NMR and mass spectrometry. The following general formula was derived: M(LMS)2Cl2, where M = Co, Ni, Cu, Zn. It was established that LMS behaved as a monodentate ligand and the coordination was accomplished through the N-7 atom. The toxicity and the immunomodulating activity of the complexes on mice and rats in comparison with uncomplexed LMS was assayed. The metals in the complexes exerted different changes in the toxicity of LMS. The complex containing Zn(II) was less toxic and manifested higher immunomodulating activity than LMS.
Kovachev
T B
TB
Higher Medical Institute, Faculty of Pharmacy, Department of Chemistry, Sofia, Bulgaria.
Stamberov
P N
PN
Ivanov
D S
DS
Mitcheva
M K
MK
Marinova
S P
SP
Astroug
H A
HA
Stoychkov
J N
JN
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D007978:Levamisole / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep / Q000276:immunology; D013055:Spectrophotometry, Infrared
D000276:Adjuvants, Immunologic; D008670:Metals; D007978:Levamisole