[Calcified aortic stenosis due to healed experimental bacterial endocarditis].
We studied the role of bacterial endocarditis in the development of aortic valve stenosis. A femoral arterio venous shunt was performed in nine dogs with the method previously proposed by Lillehei. We induced bacteremic infection with the administration of streptococcus mitis (1 x 10(10)) 10 ml once a day for 15 days these bacterium were sensible to penicillin. All dogs were treated with 1,000,000 U of benzatinic penicillin and sacrificed between 28-102 days after the bacterial inoculation ended. In one dog we observed bacterial endocarditis in the mitral and aortic valves and in other three dogs there was an aortic valve stenosis with calcium deposits in the body and in the free edges of the aortic valve with evident irregular stenosis as seen in man.
Contreras Rodríguez
R
R
Departamento de Patología, Hospital Juárez de México, México D.F.
Rodríguez Velasco
A
A
Flores Miranda
J R
JR
Ramos Amaro
J
J
D000818:Animals; D001021:Aortic Valve / Q000473:pathology; D001024:Aortic Valve Stenosis / Q000209:etiology* / Q000473:pathology; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D008297:Male; D010401:Penicillin G Benzathine / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013297:Streptococcus pyogenes; D013997:Time Factors
D010401:Penicillin G Benzathine
Estenosis aórtica calcificada por endocarditis bacteriana experimental curada.