[Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes].
The genotypes of the CYP2E1 and ALDH2 loci in alcoholic and non-alcoholic (healthy) Japanese were investigated to examine the relationship between the polymorphisms of CYP2E1 (C1/C2) and ALDH2 (ALDH2*1/ALDH2*2), and the susceptibility to alcoholism. There was no significant difference in C2 gene frequency between alcoholics (0.20) and non-alcoholics (0.19), while there was a significant difference in ALDH2 allele frequency, suggesting that the C2 allele of CYP2E1 may have nothing to the risk of developing alcoholism in Japanese, whereas the ALDH2*1 allele may influence drinking behavior and the development of alcoholism.
Iwahashi
K
K
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Nakamura
K
K
Suwaki
H
H
Miyatake
R
R
Matsuo
Y
Y
Ichikawa
Y
Y
Orino
K
K
D000437:Alcoholism / Q000201:enzymology* / Q000235:genetics; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000447:Aldehydes / Q000378:metabolism*; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics*; D011110:Polymorphism, Genetic
D000447:Aldehydes; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D000444:Aldehyde Dehydrogenase; D010089:Oxidoreductases, N-Demethylating