title: Relationship between acute suppression of plasma renin activity and lymphocyte Na+:H+ exchange rate in young patients with borderline hypertension.
abstract: The participation of the cellular sodium content and renin-angiotensin-aldosterone system in the development of high blood pressure has been frequently suggested. To elucidate the role of a mechanism responsible for renal sodium reabsorption on the time-course of renin suppression, 16 young borderline hypertensive patients were studied by analyzing the relationship between the level of baseline activation of lymphocyte Na+:H+ exchange and the degree of plasma renin activity (PRA) suppression in response to saline loading. In the whole hypertensive population, a significant correlation (R = 0.64; p < 0.01) was found between the lymphocyte Na+:H+ exchange activity and the percentage degree of PRA suppression induced by saline loading. Urinary sodium excretion was enhanced in patients with lesser activation of lymphocyte Na+:H+ exchange and greater PRA suppression (3.5 +/- 5 vs. 2.4 +/- .1 umol/min/kg; p < 0.05). These findings suggest that a mechanism influencing renal sodium reabsorption as Na+:H+ exchange could also affect the control of plasma renin activity, and concur with the development of salt-sensitive high blood pressure.
authors.affiliation: 3rd Department of Internal Medicine, University of Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Borghi
authors.forename: A
authors.initials: A
authors.lastname: Mussi
authors.forename: S
authors.initials: S
authors.lastname: Boschi
authors.forename: F V
authors.initials: FV
authors.lastname: Costa
authors.forename: E
authors.initials: E
authors.lastname: Ambrosioni
mesh_terms: D000328:Adult; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D011522:Protons; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism*
chemical_list: D011522:Protons; D012964:Sodium; D012083:Renin