Comparison of ivermectin and benzyl benzoate for treatment of scabies.
A randomized investigator-blinded trial of oral ivermectin 100 micrograms/kg single dose vs. benzyl benzoate 10% application in the treatment of scabies, was conducted in 1992 in French Polynesia. In total, 44 patients aged 5-56 years were included in the study: 23 in the group ivermectin (IVER) and 21 in the group benzyl benzoate (BB). At day 30 after treatment, the cumulative recovery rates were 70% (16/23) in the group IVER, and 48% (10/21) in the group BB, 95% confidence intervals 51-87% and 29-70% respectively. The rates of recovery were greater in the group IVER at day 7, 14 and 30, but the difference was not statistically significant. Our results show that oral ivermectin is a valuable alternative to benzyl benzoate local treatment.
Glaziou
P
P
Institut Territoreal de Recherches Médicales Louis Malardé, Papeete, Tahiti, French Polynesia.
Cartel
J L
JL
Alzieu
P
P
Briot
C
C
Moulia-Pelat
J P
JP
Martin
P M
PM
D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007306:Insecticides / Q000627:therapeutic use*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012532:Scabies / Q000188:drug therapy*; D016037:Single-Blind Method
D001565:Benzoates; D007306:Insecticides; D007559:Ivermectin; C006723:benzyl benzoate