Pharmacokinetics and distribution of selenium in blood and organs of rats.
The dynamics of selenium concentration changes in blood, organs and tissues of rats after a single intragastric administration of selenium yeast and sodium selenite was determined. The course of selenium concentration changes in blood was described, the pharmacokinetic parameters were estimated according to the trivalent equation of dicompartment model and the selenium content in liver, kidneys, small intestine, spleen, heart, brain, stomach, testicles and prostate was determined 48 h after the administration of selenium preparations.
Ryszka
F
F
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Katowice, Poland.
Dróźdź
M
M
Dolińska
B
B
Zientarska
G
G
Szulc
B
B
D000818:Animals; D008297:Male; D051381:Rats; D012643:Selenium / Q000097:blood / Q000493:pharmacokinetics*; D012644:Selenium Radioisotopes; D018038:Sodium Selenite / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015003:Yeasts
D012644:Selenium Radioisotopes; D012643:Selenium; D018038:Sodium Selenite