title: Helicobacter pylori reinfection rate, in patients with cured duodenal ulcer.
abstract: OBJECTIVE
  To determine the reinfection rate of the gastric mucosa in patients previously cured of duodenal ulcers, following the eradication of Helicobacter pylori. Only those remaining H. pylori-negative beyond 12 months of follow-up were studied, to minimize the potential inclusion of patients with H. pylori recrudescence.
  
  
  METHODS
  Patients with endoscopically proven duodenal ulcers who had been treated with triple therapy, resulting in documented eradication of H. pylori and cure of the ulcer for at least 4 years, were recalled and had their H. pylori status determined by the 14C-urea breath test. Those found positive for H. pylori underwent endoscopic confirmation of the infection.
  
  
  RESULTS
  Of the 94 patients restudied, with a follow-up period range of 48-96 months or a total of 549.8 yr, only two (2.2%) were again H. pylori positive. This gives an effective reinfection rate of 0.36% per patient year. In the two H. pylori-positive patients, one had normal mucosa endoscopically, whereas duodenitis without active ulceration was present in the other. The former was asymptomatic, whereas the latter patient was using ranitidine daily for symptom control.
  
  
  CONCLUSIONS
  In the Australian setting, following cure of duodenal ulcer disease by eradication of H. pylori, subsequent reinfection is an unusual phenomenon. We conclude that efforts aimed at eradication of H. pylori in duodenal ulcer are justified and are worthwhile.
authors.affiliation: Centre for Digestive Diseases, Five Dock, Australia.
authors.forename: T J
authors.initials: TJ
authors.lastname: Borody
authors.forename: P
authors.initials: P
authors.lastname: Andrews
authors.forename: N
authors.initials: N
authors.lastname: Mancuso
authors.forename: D
authors.initials: D
authors.lastname: McCauley
authors.forename: E
authors.initials: E
authors.lastname: Jankiewicz
authors.forename: N
authors.initials: N
authors.lastname: Ferch
authors.forename: N P
authors.initials: NP
authors.lastname: Shortis
authors.forename: S
authors.initials: S
authors.lastname: Brandl
mesh_terms: D001944:Breath Tests; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000382:microbiology*; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D013997:Time Factors