Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy.
Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cis-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.
Zastawny
T H
TH
Department of Clinical Biochemistry, Medical School, Bydgoszcz, Poland.
Olejniczak
W
W
Oliński
R
R
D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure*; D018736:DNA Adducts; D006801:Humans; D066298:In Vitro Techniques; D016252:Microscopy, Scanning Tunneling; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation / Q000187:drug effects
D018736:DNA Adducts; C057270:cisplatin-DNA adduct; D004247:DNA; D002945:Cisplatin