title: Prevalence of peptic ulcer in Helicobacter pylori positive blood donors.
abstract: This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought.
authors.affiliation: 1st Medical Clinic, University of Bologna, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Vaira
authors.forename: M
authors.initials: M
authors.lastname: Miglioli
authors.forename: P
authors.initials: P
authors.lastname: Mulè
authors.forename: J
authors.initials: J
authors.lastname: Holton
authors.forename: M
authors.initials: M
authors.lastname: Menegatti
authors.forename: M
authors.initials: M
authors.lastname: Vergura
authors.forename: G
authors.initials: G
authors.lastname: Biasco
authors.forename: R
authors.initials: R
authors.lastname: Conte
authors.forename: R P
authors.initials: RP
authors.lastname: Logan
authors.forename: L
authors.initials: L
authors.lastname: Barbara
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D001782:Blood Donors; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000453:epidemiology*; D004382:Duodenitis / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013276:Stomach Ulcer / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G