title: Termination of pacemaker-mediated tachycardia by adenosine.
abstract: A 30-year-old woman was referred for follow-up right- and left-heart catheterization 4 years after cardiac transplantation. She had an implanted epicardial pacemaker for bradycardia; this was programmed to the DDD mode. At the time of her catheterization, as a pigtail catheter was pulled back across the aortic valve, runs of premature ventricular complexes occurred and tachycardia with ventricular pacing spikes and ventricular capture was initiated at a rate of 126 beats/min. Adenosine 6 mg was given intravenously through a femoral venous sheath and within 20 s the tachycardia broke. The tachycardia was consistent with pacemaker-mediated tachycardia (PMT), a circus movement tachycardia occurring when ventricular pacing causes retrograde atrial depolarization followed by triggering of ventricular pacing. With reprogramming of the pacemaker to an AV delay of 160 ms and a postventricular atrial refractory period of 300 ms, no further episodes of PMT have occurred. This case illustrates that intravenous adenosine can effectively terminate PMT by causing ventriculoatrial block, thus interrupting the reentrant circuit by eliminating retrograde atrial activation.
authors.affiliation: University of Florida College of Medicine, Division of Cardiology, Gainesville 32610-0277.
authors.forename: J B
authors.initials: JB
authors.lastname: Conti
authors.forename: A B
authors.initials: AB
authors.lastname: Curtis
authors.forename: J A
authors.initials: JA
authors.lastname: Hill
authors.forename: E R
authors.initials: ER
authors.lastname: Raymenants
mesh_terms: D000241:Adenosine / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D013610:Tachycardia / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000241:Adenosine