Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans.
The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention.
Miller
L H
LH
Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
D017954:Africa South of the Sahara / Q000208:ethnology; D044383:Black People / Q000235:genetics*; D001789:Blood Group Antigens / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008107:Liver Diseases / Q000235:genetics; D008288:Malaria / Q000150:complications / Q000208:ethnology* / Q000401:mortality; D008659:Metabolic Diseases / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic; D014481:United States; D001741:Black or African American
D001789:Blood Group Antigens; D006680:HLA Antigens