Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula.
In rats treated systemically with either amphetamine, amfonelic acid or apomorphine, large numbers of cells displaying Fos-like immunoreactivity (FLI) could be seen in the lateral zone of the lateral habenula. The induction of FLI by amphetamine could be blocked either by pretreatment with haloperidol or by 6-hydroxydopamine lesions of ascending dopamine fibers at the level of the lateral hypothalamus. In contrast, a variety of stressors selectively induced FLI in the most medial portion of the lateral habenula. These findings support the concept of a functional differentiation of the medial and lateral regions of the lateral habenula and provide further evidence for involvement of the habenula in the circuitry of the basal ganglia.
Wirtshafter
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Department of Psychology, University of Illinois at Chicago 60680.
Asin
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KE
Pitzer
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MR
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004777:Environment; D006220:Haloperidol / Q000494:pharmacology; D007150:Immunohistochemistry; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D016761:Oncogene Proteins v-fos / Q000276:immunology / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology; D016548:Prosencephalon / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism*
D009287:Naphthyridines; D016761:Oncogene Proteins v-fos; D009268:Nalidixic Acid; D016627:Oxidopamine; D018021:Lithium Chloride; D006220:Haloperidol; D001058:Apomorphine; C006486:amfonelic acid; D003913:Dextroamphetamine; D004298:Dopamine