Amelioration by aniracetam of abnormalities as revealed in choice reaction performance and shuttle behavior.
To delineate the possible effects of aniracetam PO on abnormal behaviors, we analyzed disrupted shuttle behavior and choice reaction (CR) performance in both aged and juvenile animals subjected to an ischemic (permanent occlusion of both carotid arteries)-hypoxic (17-min exposure to 93% N2 and 7% O2 mixture gas) or ischemic (20-min occlusion of both carotid arteries) insult and/or treated with methamphetamine given IP. Aniracetam at single PO doses of 10 and 30 mg/kg significantly decreased the number of incorrect lever pressings induced by IP methamphetamine in young adult rats subjected to the CR test battery. A 21-day PO regimen with aniracetam (30 mg/kg/day) resulted in an increase in the number of correct responses and a decrease in the CR latency as detected in the CR task with young adult rats inflicted with an ischemic-hypoxic insult. Aniracetam (1-100 mg/kg PO) was also evaluated in the electrostimulation-induced hyperreactivity assay (an increase in the number of shuttle responses) in both juvenile and aged mice subjected to a 20-min ischemic insult; there again a significant improvement of performance was clearly observed. The outcomes of these behavioral pharmacological analyses suggest that aniracetam has the ability to normalize the disrupted behavior, cognition, and self-regulation or decision-making process in a comprehensive way.
Himori
N
N
Department of Pharmacology, Nippon Roche Research Center, Kamakura, Japan.
Mishima
K
K
D000818:Animals; D002545:Brain Ischemia / Q000523:psychology; D003216:Conditioning, Operant / Q000187:drug effects*; D004558:Electric Stimulation; D002534:Hypoxia, Brain / Q000523:psychology; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects*
D011760:Pyrrolidinones; D008694:Methamphetamine; C036466:aniracetam