Cytogenetic analysis of a leiomyosarcoma of the kidney.
Nonepithelial malignant renal tumors are very rare, comprising approximately 2-3% of all malignant renal tumors. We were able to culture and subsequently karyotype a leiomyosarcoma (LMS) of the kidney that showed the following representative karyotype: 84,XY,add(X)(q25),-Y,add(1)(p11),dic(1;20) (p34;q13.3),-5,-6,dup(6)(q24),i(7)(p10),add(8)(p11),-9,-11,add(13)(p11), -15,-15 , add(17)(q24)x2,-18,-19,-21,-22,-22, +mar1(?hsr),+mar2,+2mar. A clonal add(1)(q11) was also evident. The DNA index was 1.9. Our results as compared with data from the literature suggest that LMS of the kidney has most cytogenetic aberrations reported to be characteristic of LMS, especially those located in the abdomen, and that different genetic mechanisms of initiation and progression appear to play a role in LMS of similar histology but from different anatomic sites.
van den Berg
E
E
Department of Medical Genetics, University and University Hospital of Groningen, The Netherlands.
Molenaar
W M
WM
van Echten
J
J
Dam
A
A
Mensink
H J
HJ
de Jong
B
B
D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D007890:Leiomyosarcoma / Q000235:genetics*; D008297:Male; D008677:Metaphase / Q000235:genetics; D008875:Middle Aged
D004273:DNA, Neoplasm