title: Genetic polymorphism of factor B (Bf) and C3 component of complement in type 1 (insulin-dependent) diabetes mellitus: BFQO allele observed in a diabetic child.
abstract: C3 and Bf polymorphisms were studied in 215 and 192 children with type 1 diabetes mellitus (IDDM), respectively. No significant differences in C3 phenotypes and allele frequencies were found between IDDM patients and a healthy population. The rare allele BfF1 was found in 9.37% of diabetic patients but in only 0.35% of the general Slovak population (0.0468 vs. 0.0017). An increased frequency rate of BfSO.7 was also observed in 8.85% of IDDM patients compared with 3.57% of healthy controls (0.0442 vs. 0.0178). The relative risk was 28.83 for BfF1 and 2.55 for BfSO.7. One diabetic child was found to be heterozygous for a silent allele BfQO. This rare Bf allele was transmitted to the boy from his healthy mother.
authors.affiliation: Institute of Preventive and Clinical Medicine, Bratislava.
authors.forename: D
authors.initials: D
authors.lastname: Staneková
authors.forename: M
authors.initials: M
authors.lastname: Niks
authors.forename: M
authors.initials: M
authors.lastname: Buc
authors.forename: Z
authors.initials: Z
authors.lastname: Starsia
authors.lastname: Michalková
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000235:genetics*; D011415:Complement Factor B / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D003176:Complement C3; D011415:Complement Factor B