Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D.
The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
Kim
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YK
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Tomoda
H
H
Nishida
H
H
Sunazuka
T
T
Obata
R
R
Omura
S
S
D001232:Aspergillus fumigatus / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
D011725:Pyridines; D012717:Sesquiterpenes; C082792:pyripyropene A; C082793:pyripyropene B; C082794:pyripyropene C; C082795:pyripyropene D; D002785:Sterol O-Acyltransferase