[The choice of the optimal regimen for apheresis of the low-density lipoproteins in patients with familial hypercholesterolemia by using mathematical modelling].
The study was undertaken to enhance the effectiveness of a low-density lipoprotein apheresis procedure by using the mathematical approach to choosing an individual sorption regimen for each patient when the cholesterol concentration given by a physician was achieved in the shortest time. The experimental estimation of time course of changes in plasma cholesterol levels at the column inlet and outlet during low-density lipoprotein apheresis allowed the optimal parameters of the procedure to be calculated. The adequacy of the proposed methods to the real data was examined by the paired t-test (p < 0.0001). The optimal regimen was chosen for 5 patients with familial hypercholesterolemia. It is shown that the optimization of the regime will reduce the time of the procedure to 47 min, by removing the same amount of a substance.
Iarovaia
E B
EB
Rostapshova
T V
TV
Susekov
A V
AV
Kukharchuk
V V
VV
D000293:Adolescent; D000328:Adult; D001055:Apolipoproteins B / Q000032:analysis; D001781:Blood Component Removal / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D008875:Middle Aged; D008954:Models, Biological; D012044:Regression Analysis; D013997:Time Factors
D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D002784:Cholesterol
Vybor optimal'nogo rezhima afereza lipoproteidov nizkoĭ plotnosti u bol'nykh s semeĭnoĭ giperkholesterinemieĭ s ispol'zovaniem matematicheskogo modelirovaniia.