Differential effects of ethanol on the firing rates of Golgi-like neurons and Purkinje neurons in cerebellar slices in vitro.
Previous studies have demonstrated that ethanol (EtOH) inhibits the firing rate of Purkinje neurons both in vitro and in vivo. However, little is known about the response of cerebellar interneurons to EtOH. In this report, we describe the effects of locally applied EtOH on the firing of one type of cerebellar interneuron, tentatively identified as Golgi neurons, and on Purkinje cells in brain slices in vitro. The Golgi neurons were excited by EtOH, whereas EtOH depressed the firing rate of Purkinje neurons. To the best of our knowledge, this is the first report of responses of cerebellar Golgi neurons to local applications of EtOH.
Freund
R K
RK
University of Colorado Health Sciences Center, Department of Pharmacology, Denver 80262.
Wang
Y
Y
Palmer
M R
MR
D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007395:Interneurons / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000431:Ethanol