title: Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis.
abstract: The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time. Pocket depth, attachment level, bleeding on probing, gingival index and plaque index were assessed at baseline, and on days 15, 30 and 90. Analysis of data from 28 patients indicated that both debridement and metronidazole therapy decreased pocket depth, bleeding on probing and gingival index, but results were significantly better with metronidazole. These results indicate that topical metronidazole provides an effective adjunctive treatment of advanced periodontitis.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Hitzig
authors.forename: Y
authors.initials: Y
authors.lastname: Charbit
authors.forename: C
authors.initials: C
authors.lastname: Bitton
authors.forename: T
authors.initials: T
authors.lastname: Fosse
authors.forename: M
authors.initials: M
authors.lastname: Teboul
authors.forename: L
authors.initials: L
authors.lastname: Hannoun
authors.forename: R
authors.initials: R
authors.lastname: Varonne
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003094:Collagen; D003692:Delayed-Action Preparations; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000175:diagnosis; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D010518:Periodontitis / Q000188:drug therapy* / Q000628:therapy; D013357:Subgingival Curettage
chemical_list: D003692:Delayed-Action Preparations; D008795:Metronidazole; D003094:Collagen