Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp.
Discobahamin A [1] and discobahamin B [2] are two bioactive peptides isolated from a new species of the Bahamian deep water marine sponge Discodermia. The discobahamins are inhibitors of the growth of Candida albicans, and the isolation and structure elucidation of 1 and 2 by nmr and chemical methods is described.
Gunasekera
S P
SP
Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34936.
Pomponi
S A
SA
McCarthy
P J
PJ
D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001444:Bahamas; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D010456:Peptides, Cyclic; C086775:discobahamin A; C086776:discobahamin B