Human T lymphotropic virus type 1 uveitis after Graves' disease.
A distinct clinical entity of uveitis associated with human T lymphotropic virus type 1 (HTLV-I) has been reported previously. During the period between January 1989 and April 1992, 93 patients were observed with HTLV-I uveitis and a significant correlation was found between Graves' disease and HTLV-I uveitis. Sixteen of the 93 patients with HTLV-I uveitis (17.2%) had a previous history of Graves' disease. Fifteen patients were female (15/60, 25.0%) and one was male (1/33, 3.0%). Interestingly, uveitis occurred after the onset of Graves' disease in all cases. On the other hand, none of 222 patients with idiopathic uveitis who were seronegative to HTLV-I had a history of Graves' disease. Although the mechanisms by which HTLV-I causes the correlation between uveitis and Graves' disease are unknown, the present data suggest that immune mediated or autoimmune mechanisms are involved in HTLV-I uveitis.
Yamaguchi
K
K
Blood Transfusion Service, Kumamoto University Medical School, Japan.
Mochizuki
M
M
Watanabe
T
T
Yoshimura
K
K
Shirao
M
M
Araki
S
S
Miyata
N
N
Mori
S
S
Kiyokawa
T
T
Takatsuki
K
K
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D015828:Eye Infections, Viral / Q000150:complications*; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000503:physiopathology; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008297:Male; D008875:Middle Aged; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology; D014605:Uveitis / Q000150:complications*