Cross-protection between species of the Schistosoma haematobium group induced by vaccination with irradiated parasites.
Mice vaccinated with irradiated cercariae of Schistosoma haematobium, S. bovis and S. margrebowiei showed good levels of resistance (38-62%) against an homologous challenge, and varying degrees of resistance (19-46%), against challenges with closely related species. No protection against S. mansoni was induced by vaccination with any of these species. This restricted cross-protection reflects the close phylogenetic relationship between species of the S. haematobium group and indicates that immunologically important epitopes are conserved within this species complex.
Navarrete
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Wellcome Research Centre for Parasitic Infections, Department of Biology, Imperial College, London, UK.
Rollinson
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D
Agnew
A M
AM
D000818:Animals; D003429:Cross Reactions; D051379:Mice; D008808:Mice, Inbred CBA; D016052:Protozoan Vaccines; D012548:Schistosoma haematobium / Q000528:radiation effects; D012552:Schistosomiasis / Q000276:immunology / Q000517:prevention & control; D012553:Schistosomiasis haematobia / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use*
D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated