[An observation of the anticarcinogenic effect of mitoxantrone-polybutylcyanoacrylate-nanosperes].
This paper reports the result of an experiment on the anticarcinogenic effect of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) by using a model of heterotopic and orthotopic transplantation of human hepatocellular carcinoma (HCC) in nude mice. No significant difference was noted between the anti-HCC effects of mitoxantrone and dexerubicin, but the anti-orthotopic transplanting HCC effect of mitoxantrone-nanospheres was obviously higher than that of mitoxantrone and dexerubicin by comparison of tumor inhibition rates and proliferating cell nuclear antigen (PCNA). The result showed the applicability of mitoxantrone-nanospheres.
Zhang
Z
Z
Liao
G
G
Hou
S
S
Bai
S
S
Zhang
X
X
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004659:Enbucrilate; D008113:Liver Neoplasms / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008863:Microspheres; D008942:Mitoxantrone / Q000008:administration & dosage*; D009368:Neoplasm Transplantation
D004337:Drug Carriers; D008942:Mitoxantrone; D004659:Enbucrilate