On the mechanism of action of quinolone drugs.
Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.
Palumbo
M
M
Dept of Pharmaceutical Sciences, University of Padova, Italy.
Gatto
B
B
Zagotto
G
G
Palù
G
G
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D004250:DNA Topoisomerases, Type II / Q000235:genetics / Q000378:metabolism*; D004352:Drug Resistance, Microbial / Q000235:genetics; D008274:Magnesium / Q000502:physiology; D008954:Models, Biological
D042462:4-Quinolones; D000890:Anti-Infective Agents; D004250:DNA Topoisomerases, Type II; D008274:Magnesium