Synthesis and mutagenicity of a new mutagen, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline, and its analog.
A new mutagen, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline (1), isolated from beef extract, was synthesized from 3-fluoro-2-methylaniline via an intermediate, 2,8-dimethyl-7-methylaminoquinoxaline (7a). Its 2-methylanalog (2) was also synthesized from the same intermediate. The synthetic 1 showed the same mutagenic activity as the isolated mutagen. However, 2 was non-mutagenic.
Achiwa
I
I
Graduate School of Nutritional & Environmental Sciences, University of Shizuoka, Japan.
Shiozawa
T
T
Nukaya
H
H
Terao
Y
Y
D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis* / Q000633:toxicity*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics
C086687:2-amino-1,7,9-trimethylimidazo(4,5-g)quinoxaline; D009153:Mutagens; D011810:Quinoxalines