Relationship between hemorrheologic factors and insulin sensitivity in healthy young men.
The present study aimed at testing a possible relationship between hemorrheologic factors, such as hematocrit, fibrinogen, and whole-blood viscosity, and insulin sensitivity in healthy humans. Twenty-one 21-year-old men were studied with the hyperinsulinemic euglycemic glucose clamp technique. We found statistically significant negative correlations between the glucose disposal rate (GDR) and calculated whole-blood viscosity at both high (r = -.55, P = .01) and low (r = -.51, P = .01) shear rates. We observed negative associations between GDR and fibrinogen (r = -.66, P = .002), GDR and hematocrit (r = -.63, P = .002), GDR and body mass index (r = -.51, P = .007), and GDR and resting heart rate (r = -.46, P = .04). Using stepwise multiple regression considering whole-blood viscosity, body mass index, mean arterial blood pressure, and heart rate as independent variables, we found that only whole-blood viscosity and body mass index were independent explanatory variables of the GDR. Together they accounted for 63% of the variability in the GDR in our subjects. These results suggest hemorrheologic, and therefore indirectly hemodynamic, factors as correlates to insulin sensitivity.
Moan
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A
Department of Internal Medicine, Ullevaal Hospital, Oslo, Norway.
Nordby
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G
Os
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Birkeland
K I
KI
Kjeldsen
S E
SE
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D001809:Blood Viscosity / Q000502:physiology*; D002395:Catecholamines / Q000097:blood; D005340:Fibrinogen; D006400:Hematocrit; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011446:Prospective Studies; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000502:physiology
D001786:Blood Glucose; D001798:Blood Proteins; D002395:Catecholamines; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen