Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.
PMEA was administered i.p. daily on 10 consecutive days to inbred LEW rats inoculated with leukemic lymphoblastic cells KPH-Lw-I. The treatment was started 24 h after the inoculation. The observed cytostatic effects consisted in a significant prolongation of survival time associated with a suppression of the number of bone marrow leukemia cells with characteristic chromosomal marker of KPH-Lw-I leukemia as well as with a depression of the number of lymphoblasts in the blood.
Otová
B
B
Department of Biology, 1st Faculty of Medicine, Charles University, Praha.
Sladká
M
M
Votruba
I
I
Holý
A
A
Kren
V
V
D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000473:pathology; D008297:Male; D063065:Organophosphonates; D051381:Rats; D011917:Rats, Inbred Lew
D000970:Antineoplastic Agents; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine