title: Ageing and acetylcholine release by tityustoxin from brain cortical slices.
abstract: The ability of tityustoxin to trigger acetylcholine release was studied in cerebral cortical slices from 2, 12 and 23-month-old rats. The effect of tityustoxin to induce the release of acetylcholine was reduced by 60% in senescent animals. This result suggests that ageing reduces the sensitivity of cerebral cortical nerve terminals to tityustoxin.
authors.affiliation: Departamento de Farmacologia, Faculdade, de Farmácia, Instituto de Ciências Biológicas-UFMG, Belo Horizonte, Brazil.
authors.forename: I B
authors.initials: IB
authors.lastname: Queiroz
authors.forename: R M
authors.initials: RM
authors.lastname: Turchetti-Maia
authors.forename: T
authors.initials: T
authors.lastname: Moraes-Santos
authors.forename: M V
authors.initials: MV
authors.lastname: Gomez
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*
chemical_list: D012604:Scorpion Venoms; C003609:tityustoxin; D000109:Acetylcholine