[The etiological aspects of the sick sinus syndrome].
A clinico-genetic study of sick sinus syndrome in Krasnoyarsk population established its prevalence as 0.296%. The disease affected females more frequently than males. The highest morbidity was registered at the age 60-69. Genetic evaluation demonstrated high hereditary predisposition to the syndrome as it developed in 60 out of 309 (19.4%) relatives of the patients, the inheritance being autosomal dominant and in part sex-limited. Females predominated among the disease-affected relatives and among those whose relatives had the syndrome. The syndrome is also age-related. The authors discuss the role of ischemic heart disease in the origin of sick sinus syndrome.
Shul'man
V A
VA
Nikulina
S Iu
SIu
Puzyrev
V P
VP
Saliukov
V B
VB
Matiushin
G V
GV
Kusaev
V V
VV
D000328:Adult; D017677:Age Distribution; D000368:Aged; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution; D012800:Siberia / Q000453:epidemiology; D012804:Sick Sinus Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D014505:Urban Population / Q000706:statistics & numerical data
Nekotorye étiologicheskie aspekty sindroma slabosti sinusovogo uzla.