title: Benign myocardial uptake of hydroxymethylene diphosphonate.
abstract: During 'routine' bone scanning with diphosphonates, 10 elderly men were noted to show prominent myocardial uptake of Tc-hydroxymethylene diphosphonate (HDP) consistently, but no heart activity was seen with Tc-methylene disphosphonate (MDP). None had evidence of recent myocardial injury and the uptake persisted over a period of many months. In some, myocardial uptake defects were noted, analogous to 201Tl- and Tc-methoxyisobutyl isonitrile (MIBI) scans postinfarction. The condition appears to be essentially benign but its aetiology remains obscure. We have not been able to identify its cause; presumably atherosclerosis is one factor.
authors.affiliation: Department of Nuclear Medicine, Derriford Hospital, Plymouth, UK.
authors.forename: A
authors.initials: A
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Keeling
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002326:Cariogenic Agents / Q000493:pharmacokinetics; D004164:Diphosphonates / Q000493:pharmacokinetics*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism*
chemical_list: D002326:Cariogenic Agents; D004164:Diphosphonates; C029285:hydroxymethanediphosphonic acid