title: Effects of hypertonic saline solutions in the coronary circulation.
abstract: The use of small-volume injections of hypertonic saline solutions (HSS) in resuscitation from hemorrhagic shock is accompanied by well-maintained and pronounced increases in coronary blood flow (CBF) and by increases in myocardial contractility. The present study was performed in open-chest, anesthetized dogs to evaluate the contribution of direct coronary vasodilator and positive inotropic effects of HSS to these therapeutic responses. The left anterior descending coronary artery (LAD) was cannulated and perfused at constant pressure (100 mm Hg) with normal arterial blood. CBF in LAD was measured electromagnetically, and used to calculate myocardial oxygen consumption (MVO2) and coronary arterial plasma osmolality. Percent segmental shortening in LAD bed (% SS) was evaluated with ultrasonic crystals. Measurements were obtained during infusion into LAD of 2.5, 5.0, and 7.5% HSS at 2 ml/min. These HSS solutions yielded calculated plasma osmolalities of 329 +/- 3, 361 +/- 8, and 378 +/- 10 mOsm/kg, respectively. The increases in plasma osmolality by 2.5% HSS were in the therapeutic range, whereas those by 5.0 and 7.5% HSS were supertherapeutic. HSS caused initial peak increases in CBF (reflecting decreases in coronary vascular resistance), which waned rapidly to achieve modest steady-state increases within 2-3 min. The magnitude of the peak and steady-state increases in CBF by HSS correlated to osmolality. The 2.5% HSS had no effect on MVO2 and % SS, whereas the 5.0% and 7.5% HSS increased these variables in an osmolality-dependent manner.
  
  
  CONCLUSIONS
  (1) intracoronary infusions of HSS caused modest steady-state coronary vasodilation, (2) Supertherapeutic elevations of plasma osmolality by HSS were required for direct positive inotropic effects, and (3) the present findings suggest that the direct cardiac actions of HSS contribute minimally to the increases in coronary blood flow and myocardial contractility that follow the use of these solutions for resuscitation from hemorrhagic shock.
authors.affiliation: Department of Anesthesiology, Illinois Masonic Medical Center, Chicago 60657.
authors.forename: G J
authors.initials: GJ
authors.lastname: Crystal
authors.forename: J
authors.initials: J
authors.lastname: Gurevicius
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.forename: P K
authors.initials: PK
authors.lastname: Eckel
authors.forename: E F
authors.initials: EF
authors.lastname: Ismail
authors.forename: M R
authors.initials: MR
authors.lastname: Salem
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D006706:Homeostasis; D006982:Hypertonic Solutions; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D014664:Vasodilation
chemical_list: D006982:Hypertonic Solutions; D012462:Saline Solution, Hypertonic; D008353:Mannitol