The growth hormone response to baclofen in obsessive compulsive disorder: does the GABA-B receptor mediate obsessive anxiety?
The growth hormone (GH) response to the gamma amino butyric acid type B (GABA-B) receptor agonist baclofen was measured in 10 Caucasian out-patients with DSM-III-R obsessive compulsive disorder (OCD) and 10 healthy comparison subjects. The patients also underwent a dexamethasone suppression test. The GH response was similar in both groups and there was a low rate of dexamethasone non-suppression in the patients. The data do not suggest that GABA-B receptor dysfunction is a feature of obsessive anxiety.
Lucey
J V
JV
Maudsley Hospital, London, United Kingdom.
Butcher
G
G
O'Flynn
K
K
Clare
A W
AW
Dinan
G
G
D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D018080:Receptors, GABA-B / Q000502:physiology*
D018080:Receptors, GABA-B; D013006:Growth Hormone; D001418:Baclofen