Regulation of interleukin-5 production by interleukin-4, interferon-alpha, transforming growth factor-beta and interleukin-6.
Normal lymphocytes produce IL-5 with PHA and PMA stimulation. In this system, IL-5 production was enhanced by IL-4 and was inhibited by IFN alpha, TGF beta and IL-6.
Enokihara
H
H
Third Department of Internal Medicine, Dokkyo University, School of Medicine, Tochigi, Japan.
Nakamura
Y
Y
Nagashima
S
S
Furusawa
S
S
Shishido
H
H
D004804:Eosinophils / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D015848:Interleukin-5 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000494:pharmacology*; D008214:Lymphocytes / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D016898:Interferon-alpha; D015848:Interleukin-5; D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D015847:Interleukin-4