Two new cytotoxic peroxide-containing acids from a New Guinea sponge, Callyspongia sp.
Two new C14 cytotoxic, branched-chain acids, 1 and 2, containing a cyclic peroxide moiety were isolated from a sponge, Callyspongia sp., collected in New Guinea. The structures were elucidated through extensive spectral analysis.
Toth
S I
SI
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019.
Schmitz
F J
FJ
D000085:Acetates / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004146:Dioxanes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009512:New Guinea; D011161:Porifera / Q000737:chemistry*
D000085:Acetates; D000970:Antineoplastic Agents; D004146:Dioxanes