Acute effect of topical carteolol on ocular pulsatile volume change.
To determine whether topical carteolol affects ocular blood flow, we studied effects of carteolol 2% on the ocular pulse waves in 9 normal volunteers, and analyzed the results as variations in pulsatile volume changes (PVC) for one minute (PVCm) using the Friedenwald's pressure-volume relationship. PVC means a volume for the pressure amplitude in each pulse. The pulse waves were recorded with a pneumatonometer and analyzed by a computer. The PVCm change 15 min after the carteolol instillation was evaluated with the control performed with biological salt solution in the same manner. The data showed a net increase in the PVCm of the carteolol-instilled eyes (21.3 +/- 6.4 microliters/min: mean +/- standard error, p < 0.05, paired t-test). Considering a finding that PVCm takes 50% of the total ocular blood flow, the results suggest a possible alteration in the total flow by a carteolol instillation.
Yamazaki
S
S
Department of Ophthalmology, Tokyo Medical and Dental University, Nagasaki, Japan.
Baba
H
H
D000287:Administration, Topical; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D002354:Carteolol / Q000494:pharmacology*; D005123:Eye / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011673:Pulsatile Flow / Q000187:drug effects; D014065:Tonometry, Ocular
D009883:Ophthalmic Solutions; D002354:Carteolol