A diet containing the lectin phytohaemagglutinin (PHA) slows down the proliferation of Krebs II cell tumours in mice.
Mice injected intraperitoneally with Krebs II cells and then fed on a diet containing the lectin phytohaemagglutinin (PHA) developed ascites tumours more slowly than mice fed on a control diet. After an 8-day period following injection the number of cells recovered from mice maintained on the PHA diet was half that from those fed the control diet. A switch of diet from control to PHA on day 4 after injection resulted in a large decrease in number of tumour cells recovered. Mice injected s.c. also developed tumours at later times when fed on the PHA diet. A quantitative of ribosomes in polysome-containing fractions showed no major differences in protein synthesis in control mice and those fed the PHA diet.
Pryme
I F
IF
Department of Biochemistry and Molecular Biology, University of Bergen, Norway.
Pusztai
A J
AJ
Bardocz
S
S
D000818:Animals; D001201:Ascites; D001835:Body Weight / Q000187:drug effects; D002287:Carcinoma, Krebs 2 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004032:Diet; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011132:Polyribosomes / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
D009363:Neoplasm Proteins; D010835:Phytohemagglutinins