A study of autoantibodies to phosphatidyl-serine in Babesia bovis and Babesia bigemina infections in cattle.
Sera from cattle infected with Babesia bovis were found to contain antibodies to phosphatidyl-serine (PS), a negatively charged phospholipid normally found on the internal membrane of erythrocytes. In contrast, no autoantibodies were detected following Babesia bigemina infection indicating that the autoimmunity is not genus specific. During infection with Babesia bovis, PS translocates to the external membrane and it is suggested that this may result in PS behaving as an autoantigen owing to a transitional change. These autoantibodies may also play some role in the pathology of infection, especially the disturbed coagulation system associated with acute Babesia bovis infection.
Orinda
G O
GO
CSIRO, Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, Qld., Australia.
Commins
M A
MA
Waltisbuhl
D J
DJ
Goodger
B V
BV
Wright
I G
IG
D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D016793:Babesia bovis / Q000276:immunology*; D001404:Babesiosis / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D010718:Phosphatidylserines / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D010718:Phosphatidylserines