Comparative effects of neutron irradiation and X irradiation on the embryonic development of the rat.
Our aim was to compare the dose-response relationship for the embryotoxic effects of 0.43 MeV neutrons with those of 240 kVp X rays after in utero exposures during early organogenesis in the rat. At 9.5 days after conception, pregnant rats were exposed to 0.025 to 0.35 Gy 0.43 MeV neutrons at a dose rate of 0.04 to 0.07 Gy/h. Comparable biological effects were produced using 0.50 to 2.05 Gy 240 kVp X rays. Neutron irradiation produced a greater proportion of offspring with very low body weight than with malformations when compared to X rays. There were no embryotoxic effects observed at neutron exposures of 0.025, 0.049, 0.079, 0.10, 0.15 and 0.20 Gy or X-ray exposures of 0.50 and 0.96 Gy. Taken together, the results suggest that the mechanisms by which neutron irradiation affects embryonic development may, in part, be both quantitatively and qualitatively different from those by which X irradiation affects development. These results support the generalization that the embryo exhibits a nonlinear response to increasing doses of ionizing radiations during the period of early organogenesis.
Solomon
H M
HM
Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
Beckman
D A
DA
Buck
S J
SJ
Gorson
R O
RO
Mills
R E
RE
Brent
R L
RL
D000016:Abnormalities, Radiation-Induced / Q000209:etiology; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005314:Embryonic and Fetal Development / Q000528:radiation effects*; D005260:Female; D008297:Male; D009502:Neutrons; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014965:X-Rays