title: Extracorporeal circulation as a blood conservation technique for extensive pelvic operations.
abstract: Difficult pelvic operations for malignancy or complex benign conditions can be associated with extensive blood loss. Religious beliefs that preclude transfusion and the known risks of homologous blood have prompted investigators to seek alternatives to transfusion. We used the Haemonetics-V50 Cell Separator (Haemonetics Corporation) to provide for extracorporeal circulation of the patient's own blood with associated normovolemic hemodilution as a means of conserving blood during operations. This technique was used in eight patients undergoing extensive pelvic operations. The procedure was accepted by Jehovah's Witnesses and was well tolerated by all patients. Estimated blood loss ranged from 75 to 2,000 milliliters. One instance of mild intraoperative disseminated intravascular coagulation was encountered. Two patients were given homologous transfusions. While clinical judgment is necessary to determine the safety of complicated operations, this technique is useful in expanding surgical options for some patients who object to blood transfusion.
authors.affiliation: Department of Gynecology, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: J L
authors.initials: JL
authors.lastname: Kelley
authors.forename: T W
authors.initials: TW
authors.lastname: Burke
authors.forename: B
authors.initials: B
authors.lastname: Lichtiger
authors.forename: J F
authors.initials: JF
authors.lastname: Dupuis
mesh_terms: D016063:Blood Loss, Surgical; D001793:Blood Preservation / Q000295:instrumentation; D001803:Blood Transfusion / Q000295:instrumentation / Q000379:methods; D001804:Blood Transfusion, Autologous / Q000295:instrumentation; D002469:Cell Separation / Q000295:instrumentation; D002835:Christianity; D005112:Extracorporeal Circulation / Q000295:instrumentation*; D005260:Female; D006438:Hemodilution; D006801:Humans; D008297:Male; D010386:Pelvic Neoplasms / Q000601:surgery*; D012068:Religion and Medicine