Nephrogenic diabetes insipidus: causes revealed.
In congenital NDI, the failure of the renal tubules to respond to antidiuretic hormone is caused by mutation of the arginine vasopressin receptor gene. Two dozen different mutations have been identified to date--all with the same clinical consequences. Several causes of acquired NDI, of which lithium is the most common, are also discussed.
Holtzman
E J
EJ
Harvard University.
Ausiello
D A
DA
D001127:Arginine Vasopressin / Q000097:blood* / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA; D003707:Demeclocycline / Q000009:adverse effects; D003919:Diabetes Insipidus / Q000097:blood / Q000139:chemically induced / Q000151:congenital* / Q000235:genetics* / Q000652:urine; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008094:Lithium / Q000009:adverse effects; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D017483:Receptors, Vasopressin / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D014960:X Chromosome
D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D003707:Demeclocycline; D004247:DNA; D008094:Lithium