title: Cholesterol synthesis inhibitors inhibit more than cholesterol synthesis.
abstract: The beneficial effects of HMG-CoA reductase inhibition in models of progressive glomerular injury may not all be due to reductions in circulating lipoproteins and decreases in glomerular lipoprotein deposition. Indeed, HMG-CoA reductase inhibitors may have direct effects on glomerular mesangial cells that could explain the amelioration of renal injury. Specifically, HMG-CoA reductase inhibitors block the synthesis of isoprenoids that are necessary for mesangial cell proliferation and other important cell functions. Thus, protein isoprenylation may play a critical role in the pathogenesis and treatment of lipid-induced glomerular injury.
authors.affiliation: Department of Medicine Hennepin County Medical Center, Minneapolis, Minnesota.
authors.forename: B L
authors.initials: BL
authors.lastname: Kasiske
authors.forename: M P
authors.initials: MP
authors.lastname: O'Donnell
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: D
authors.initials: D
authors.lastname: Atluru
authors.forename: W F
authors.initials: WF
authors.lastname: Keane
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002455:Cell Division; D002633:Chemotaxis; D005920:Glomerular Mesangium / Q000166:cytology / Q000502:physiology; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017368:Protein Prenylation
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006903:Hydroxymethylglutaryl CoA Reductases