title: Cefminox: correlation between in-vitro susceptibility and pharmacokinetics and serum bactericidal activity in healthy volunteers.
abstract: Plasma concentration of cefminox and serum bactericidal activity against four ATCC strains (Escherichia coli 25992, Klebsiella pneumoniae 13833, Serratia marcescens 8100 and Bacteroides fragilis 25285), were determined over a 24 h period after administration of cefminox 1 and 2 g to six healthy volunteers in a randomized, cross-over, single blind study. The increase observed in the area under the bactericidal curve (AUBC) with the 2 g dose was at least 3.5 times that seen with the 1 g dose for all four test strains and was larger than predicted by the corresponding increase (1.84 times) in the area under the serum concentration versus time curve (AUC); a correlation (r = 0.88, P = 0.0001) between the cefminox concentration and the serum bactericidal titres was, however, observed with all four strains tested. The MBC6h showed a better association with the serum bactericidal titre (P < 0.01) than did the MIC or MBC.
authors.affiliation: Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Aguilar
authors.forename: C
authors.initials: C
authors.lastname: Esteban
authors.forename: J
authors.initials: J
authors.lastname: Frias
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Balcabao
authors.forename: A J
authors.initials: AJ
authors.lastname: Carcas
authors.forename: R
authors.initials: R
authors.lastname: Dal-Ré
mesh_terms: D000328:Adult; D001419:Bacteria / Q000187:drug effects*; D001681:Biological Assay; D002513:Cephamycins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015610:Serum Bactericidal Test; D016037:Single-Blind Method
chemical_list: D002513:Cephamycins; C046079:cefminox