title: Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors.
abstract: Alterations of the short arm of chromosome 1 are recurrently found in cytogenetic analysis of malignant gliomas, and deletions of 1p36-p32 region characterize at least the higher-grade tumors, glioblastoma multiforme. Molecular analysis of tumor-derived and normal genomic DNA from 57 cases of gliomas, using a panel of chromosome 1-specific DNA probes showed LOH in 16 tumors. Allelic losses on 1p were primarily restricted to glioblastoma multiforme (2/11) and to tumors with a major oligodendroglial component: grade II oligodendrogliomas (6/6), grade III anaplastic oligodendrogliomas (5/6) and grade II-III mixed oligo-astrocytomas (2/3). Losses for 1q markers were detected in only 1 tumor (glioblastoma multiforme). Our data suggest that anomalies of 1p primarily characterize oligodendrogliomas, whereas they are rare events in astrocytic tumors and indicate that a tumor-suppressor gene on 1p36-p32 is involved in the development of brain tumors with oligodendroglial differentiation.
authors.affiliation: Biomedical Research Institute (CSIC), Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bello
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: J M
authors.initials: JM
authors.lastname: de Campos
authors.forename: M E
authors.initials: ME
authors.lastname: Kusak
authors.forename: J L
authors.initials: JL
authors.lastname: Sarasa
authors.forename: J
authors.initials: J
authors.lastname: Saez-Castresana
authors.forename: A
authors.initials: A
authors.lastname: Pestana
authors.forename: J A
authors.initials: JA
authors.lastname: Rey
mesh_terms: D000483:Alleles; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D005910:Glioma / Q000235:genetics*; D006801:Humans; D009837:Oligodendroglioma / Q000235:genetics*