[The search for the DNA sequences characterizing the granulocytic lineage of cell differentiation in the HL-60 line].
cDNA of HL-60 cells induced to differentiation into granulocytes was hybridized with the excess of mRNA of K 562 cells induced to differentiation into erythrocytes. Cloning of cDNA sequences characterizing the induced differentiation of HL-60 cells into granulocytes was performed. The clones obtained were shown to contain sequences encoding a zinc finger motif, which is specific for DNA-binding domain of protein activators of transcription.
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D002454:Cell Differentiation; D002999:Clone Cells / Q000166:cytology; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D004912:Erythrocytes / Q000166:cytology; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000473:pathology; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D014407:Tumor Cells, Cultured / Q000166:cytology; D016335:Zinc Fingers / Q000235:genetics
D018076:DNA, Complementary; D004273:DNA, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm
Poisk DNA-posledovatel'nosteĭ, kharakterizuiushchikh granulotsitarnoe napravlenie differentsirovki kletok linii HL-60.