title: Adjunctive use of transconjunctival mitomycin-C in ab externo diode laser sclerostomy surgery in rabbits.
abstract: This study evaluates the role of transconjunctival mitomycin-C (MMC) in laser sclerostomy surgery. Sixteen albino rabbits underwent ab externo diode laser sclerostomy surgery in one eye (with the fellow eye as a control), with a single, intraoperative, 7-minute transconjunctival application of MMC (MMC group). Ten rabbits had the same sclerostomy surgery without MMC (NOMMC group). Successful filtration, defined as a difference in intraocular pressure less than 4 mm Hg between the operative and control eyes, lasted significantly longer in the MMC group (16.4 +/- 11.0 days) than in the NOMMC group (8.5 +/- 4.5 days) (P = .02). These data suggest that transconjunctival MMC can enhance the success of diode laser sclerostomy surgery in rabbits.
authors.affiliation: W.K. Kellogg Eye Center, University of Michigan, Department of Ophthalmology, Ann Arbor 48105.
authors.forename: C L
authors.initials: CL
authors.lastname: Karp
authors.forename: E J
authors.initials: EJ
authors.lastname: Higginbotham
authors.forename: E O
authors.initials: EO
authors.lastname: Griffin
mesh_terms: D000818:Animals; D017024:Chemotherapy, Adjuvant; D003228:Conjunctiva; D005901:Glaucoma / Q000601:surgery; D007429:Intraocular Pressure; D053685:Laser Therapy / Q000379:methods*; D016685:Mitomycin / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D011817:Rabbits; D012599:Sclerostomy / Q000379:methods*; D014130:Trabeculectomy
chemical_list: D009883:Ophthalmic Solutions; D016685:Mitomycin