Effect of praziquantel treatment on lipid peroxide levels and superoxide dismutase activity in tissues of healthy and Schistosoma mansoni infected mice.
The elevated levels of lipid peroxide product as malondialdehyde (MDA) in plasma, liver, spleen, intestine and kidney of Schistosome-infected mice were differently ameliorated by treatment with praziquantel (EMBAY 8440, CAS 55268-74-1) (2 x 500 mg/kg body wt.) being nearly normalized in plasma and intestine, moderately improved in liver and slightly affected in spleen and kidney. However, the drug failed to affect the MDA levels in the different organs of healthy mice. Moreover, the increased hepatic superoxide dismutase (SOD) activity in infected mice was normalized while the decreased activities in the other tissues were further decreased than normal values in response to praziquantel treatment. Interestingly, in healthy mice, the drug similarly inhibited SOD activities in blood, spleen and kidney. The specificity of this action remains to be clarified. Possible explanations of these findings are given.
Shaheen
A A
AA
Biochemistry Department, Faculty of Pharmacy, Cairo University, Egypt.
Abd el-Fattah
A A
AA
Ebeid
F A
FA
D000818:Animals; D007668:Kidney / Q000201:enzymology; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology*; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000201:enzymology / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism*
D008054:Lipid Peroxides; D008315:Malondialdehyde; D011223:Praziquantel; D013482:Superoxide Dismutase