title: Atrial natriuretic peptide-like immunoreactive material (ANP-LI) is released from the adrenal gland by splanchnic nerve stimulation.
abstract: We investigated the release of atrial natriuretic peptide-like immunoreactive material (ANP-LI) after splanchnic nerve stimulation of isolated perfused adrenal glands. Electrical stimulation of the splanchnic nerves caused a statistically significant increase of ANP-LI (186 +/- 12 pg.min-1; p < 0.05) at 5 min. after stimulation. The integrated ANP-LI release after stimulation was amounted to 354 +/- 6.8% over basal. The regulation of ANP through the sympathoadrenal system may indicate an important role of ANP in adrenal steroidogenesis.
authors.affiliation: Department of Internal Medicine I, University of Ulm, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Duntas
authors.forename: S R
authors.initials: SR
authors.lastname: Bornstein
authors.forename: W A
authors.initials: WA
authors.lastname: Scherbaum
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000276:immunology / Q000378:metabolism*; D004558:Electric Stimulation; D011863:Radioimmunoassay; D013153:Splanchnic Nerves / Q000502:physiology*; D013552:Swine
chemical_list: D009320:Atrial Natriuretic Factor