title: Comparison of technetium-99m-Q3 and thallium-201 for detection of coronary artery disease in humans.
abstract: Technetium-99m-Q3 is a myocardial imaging agent that produces prompt myocardial visualization in humans.
  
  
  METHODS
  In 19 patients with angiographic coronary artery disease, 2 patients with no angiographic coronary artery stenosis greater than 50% of the luminal diameter and 6 healthy volunteers, exercise and resting myocardial imaging were performed with 99mTc-Q3 and also with 201Tl. Technetium-99m-Q3 imaging began 15 min after injection at rest and with exercise, in a complete imaging sequence that required less than 100 min.
  
  
  RESULTS
  Overall accuracy for coronary disease detection was 78% (21 true-positive or true-negative studies among 27 study participants) by tomographic thallium imaging versus 89% for 99mTc-Q3 tomographic imaging (p = ns). Accuracy for detection of individual coronary stenoses was 75% (61 true-positive or true-negative coronary segment classifications among 81 total coronary segments) for 201Tl imaging and 83% for 99mTc-Q3 imaging (p = ns).
  
  
  CONCLUSIONS
  Technetium-99m-Q3 when used in a rest-exercise sequence that can be completed in 100 min appears to provide comparable diagnostic accuracy to 201Tl for overall coronary disease detection and detection of individual coronary artery stenoses.
authors.affiliation: Department of Internal Medicine, University of Cincinnati, Ohio 45267-0542.
authors.forename: M C
authors.initials: MC
authors.lastname: Gerson
authors.forename: J
authors.initials: J
authors.lastname: Lukes
authors.forename: E
authors.initials: E
authors.lastname: Deutsch
authors.forename: D
authors.initials: D
authors.lastname: Biniakiewicz
authors.forename: L C
authors.initials: LC
authors.lastname: Washburn
authors.forename: A H
authors.initials: AH
authors.lastname: Elgazzar
authors.forename: R C
authors.initials: RC
authors.lastname: Elder
authors.forename: R A
authors.initials: RA
authors.lastname: Walsh
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010720:Phosphines; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
chemical_list: D015609:Organotechnetium Compounds; D010720:Phosphines; D013794:Thallium Radioisotopes; C081212:technetium Tc 99m Q3