Attachment factors of Bordetella pertussis: mimicry of eukaryotic cell recognition molecules.
Bacteria localize to specific target organs during infection by recognizing eukaryotic cell surface addresses. This address system exists to facilitate normal trafficking of host cells such as leukocytes. The mechanisms by which bacteria subvert host targeting codes provide a unique link between microbial pathogenesis and eukaryotic cell trafficking, and can point to a new array of antibodies and peptides of potential therapeutic value.
Sandros
J
J
Laboratory of Molecular Infectious Diseases, Rockefeller University, New York, NY 10021.
Tuomanen
E
E
D000595:Amino Acid Sequence; D001422:Bacterial Adhesion; D001886:Bordetella pertussis / Q000235:genetics / Q000472:pathogenicity*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D006388:Hemagglutinins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D014774:Virulence; D010566:Virulence Factors, Bordetella / Q000235:genetics / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D006388:Hemagglutinins; D010566:Virulence Factors, Bordetella