title: The primary structure of pancreatic ribonuclease from mole rat superspecies Spalax leucodon.
abstract: The primary structure of pancreatic ribonuclease of the superspecies Spalax leucodon has been determined. Only one difference with the previously determined sequence of the superspecies Spalax ehrenbergi was detected; the proline residue at position 42 has been replaced by alanine. Proline-42 is a well-conserved residue in mammalian pancreatic ribonucleases; the only other species with alanine at this position is the three-toed sloth. As the Muridae and the Spalacidae diverged 20-40 million years ago and the superspecies S. leucodon and S. ehrenbergi about 1-2 million years ago, and as pancreatic ribonuclease exhibits 24 substitutions in the line from the Muridae/Spalacidae ancestor to Spalax, a difference of one amino residue between the sequences of the two Spalax superspecies is what may be expected.
authors.affiliation: Biochemisch Laboratorium, Rijksuniversiteit Groningen, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: J J
authors.initials: JJ
authors.lastname: Beintema
authors.forename: J
authors.initials: J
authors.lastname: Hofsteenge
authors.forename: E
authors.initials: E
authors.lastname: Nevo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D017124:Conserved Sequence; D014644:Genetic Variation; D008322:Mammals / Q000235:genetics; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics; D010179:Pancreas / Q000201:enzymology*; D012260:Ribonucleases / Q000737:chemistry / Q000235:genetics*; D012377:Rodentia / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014421:Turkey
chemical_list: D012260:Ribonucleases