Relationship between the tissue distribution and antitumor activity of highly branched (1-->3)-beta-D-glucan, SSG.
Distribution of 3H-labeled (1-->3)-beta-D-glucan([3H]SSG) obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395, in various tissues in tumor-bearing mice was examined. [3H]SSG administered intra-peritoneally was mainly detected in liver, spleen, kidney and tumor masses. In contrast to i.p. administration, intra-lesionally administered [3H]SSG was not released from the tumor. Similarly, in a double grafted tumor system, [3H]SSG was located in the administered tumor and not distributed in the distant site tumor, in spite of the fact that significant antitumor effect was shown in both tumor sites in this system. Winn assay confirmed the activation of the systemic antitumor immunity. These results suggested that the distribution of glucans would be one important factor in determining their antitumor effects. However, this would not always be necessary if systemic immunity could be induced.
Suda
M
M
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Japan.
Ohno
N
N
Adachi
Y
Y
Yadomae
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005354:Fibrosarcoma / Q000378:metabolism / Q000628:therapy; D005936:Glucans / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007155:Immunologic Factors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000378:metabolism / Q000628:therapy*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D047071:beta-Glucans
D000970:Antineoplastic Agents; D005936:Glucans; D007155:Immunologic Factors; D047071:beta-Glucans; C033363:beta-1,3-glucan