[The radiotherapeutic effect of the CM-5 fraction of turtle spleen extract].
CM-5 fraction of tortoise spleen extract injected after irradiation in dose CD50/30 (540 R) raises a survival of mice to 73.4%. The number of endocolonies of spleen increases to 4.0 in experiment against 0.3 in control and the average life of experimental animals increases to 12.7 days against 8.8 in control. In vitro it has been found a considerable increase of RNA-synthetic activity of bone marrow cells stimulated by CM-5 fraction in post-irradiation period. The dose alteration factor for CM-5 fraction is 1.46 according to CD50/30 standard at survival test.
Prus
E K
EK
Turdyev
A A
AA
Trifonov
Iu A
IuA
Voloshin
S V
SV
Usmanov
R B
RB
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013154:Spleen; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use*; D014426:Turtles; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D014020:Tissue Extracts
Radioterapevticheskiĭ éffekt fraktsii CM-5 ékstrakta selezenki cherepakhi.