[Properties of polyreactive immunoglobulins].
Some biological properties of polyreactive antibodies (PRABs) from the serum of mice, rabbit and cattle are investigated. Optimal parameters of the activation process are determined. It is shown that solution of KSCN (potassium rhodanide) more effectively impedes interaction of PRABs with the antigen on the immunological plate than interaction between specific antibodies. Dynamics of binding of PRABs and affine-purified antibodies to an immobilized antigen is analyzed. The competitive ELISA shows the absence of specificity of PRABs and their less avidity in comparison with the usual antibodies. It is supposed that PRABs play an essential role in the immune system of animals and man.
Bobrovnik
S A
SA
Marinets
A V
AV
D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002417:Cattle; D004797:Enzyme-Linked Immunosorbent Assay; D007136:Immunoglobulins / Q000276:immunology*; D051379:Mice; D011817:Rabbits
D007136:Immunoglobulins
Issledovanie nekotorykh svoĭstv polireaktivnykh immunoglobulinov.