Disease profile of 400 institutionalized mentally retarded patients in Kuwait.
In this preliminary report we summarize the results of a 4-year multidisciplinary systematic, etiological clinicogenetic survey of 400 institutionalized mentally retarded patients in Kuwait. All had an intelligence quotient below 50. A constitutional disorder, as the direct cause of the mental retardation, was found in 203 patients (50.75%)): a chromosomal abnormality in 37 (9.25%), Mendelian disorders in 137 (34.25%), MCA/MR in 22 (5.55%) and CNS malformations in 7 cases (1.75%). In 157 patients (39.35%) a pre-, peri or postnatal cause was ascertained. No etiological diagnosis was detected in 40 patients (10%). A detailed analysis of the "disease profile" is given and compared with the results of previous diagnostic genetic surveys among different institutionalized mentally retarded populations in Western and developing countries.
Farag
T I
TI
Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic.
al-Awadi
S A
SA
el-Badramary
M H
MH
Aref
M A
MA
Kasrawi
B
B
Krishna Murthy
D S
DS
el-Khalifa
M Y
MY
Yadav
G
G
Marafie
M J
MJ
Bastaki
L
L
D000015:Abnormalities, Multiple; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003241:Consanguinity; D005260:Female; D006306:Health Surveys; D006801:Humans; D007326:Institutionalization; D008607:Intellectual Disability / Q000209:etiology / Q000235:genetics*; D007730:Kuwait; D008297:Male; D010375:Pedigree; D013577:Syndrome