title: HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates.
abstract: A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM against HIV-1 (RF) and 2-8 microM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.
authors.affiliation: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201.
authors.forename: T C
authors.initials: TC
authors.lastname: McKee
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: R
authors.initials: R
authors.lastname: Riccio
authors.forename: M V
authors.initials: MV
authors.lastname: D'Auria
authors.forename: M
authors.initials: M
authors.lastname: Iorizzi
authors.forename: L
authors.initials: L
authors.lastname: Minale
authors.forename: R A
authors.initials: RA
authors.lastname: Moran
authors.forename: R J
authors.initials: RJ
authors.lastname: Gulakowski
authors.forename: J B
authors.initials: JB
authors.lastname: McMahon
authors.forename: R W
authors.initials: RW
authors.lastname: Buckheit
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004447:Echinodermata / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013463:Sulfuric Acid Esters / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D013261:Sterols; D013463:Sulfuric Acid Esters