title: [ROC analysis of tumor identification using 201Tl-(I)-chloride and 99mTc-(I)-hexakis (2-methoxy-2-isobutylisonitrile].
abstract: We investigated tumor detectability of bronchial carcinoma using 201Tl and 99mTc-MIBI with planar scintigraphy and SPECT. We studied 30 tumor patients and 7 patients with coronary artery disease in a clinical phase III trial. The lung was partitioned into 6 areas, which were read independently, to provide a sufficiently large sample of tumor-free reference regions. We calculated the statistical power for the comparison of sensitivities at a given specificity of 95% (TPF-test) to demonstrate that the subdivision of the lung and the application of the bivariate bi-normal ROC model allows an objective assessment of diagnostic performance even for the small sample size of our study. There were no significant differences between 201Tl and 99mTc-MIBI for both observers; therefore, no advantage of 99mTc-MIBI over 201Tl for tumor scintigraphy could be demonstrated. SPECT was significantly superior to planar scintigraphy and should be preferred for tumor detection in the thorax.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Essen, FRG.
authors.forename: S P
authors.initials: SP
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Paas
authors.forename: C
authors.initials: C
authors.lastname: Reiners
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D002283:Carcinoma, Bronchogenic / Q000000981:diagnostic imaging*; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi
vernacular_title: ROC-Analyse der Tumorerkennbarkeit mit 201Tl (I) Chlorid und 99mTc (I) Hexakis (2-Methoxy-2-Isobutylisonitril).