title: [Medullary thyroid carcinoma: prognostic factors].
abstract: Fifty-one patients treated by total thyroidectomy plus nodal neck dissection of necessity for medullary thyroid carcinoma (MTC) with a minimum follow-up of 10 years (mean 14.5, max 22 years) were divided into three groups according to the outcome (alive disease-free; alive with disease; dead) and were compared in order to analyze the prognostic factors of MTC. Twenty years actuarial survival rate for age at diagnosis less than 50 years versus age over 50 (90% vs 45%) as well as for stage II versus stage III (85% vs 55%) was statistically different (p < 0.005 and p < 0.05 respectively). About 60% of recurrences were observed within 5 years after surgical treatment. Recurrence rate for stage III (70%) versus stage II (20%) was statistically different, but it was not for the age. Survival rate for patients with bony metastases (50% at 1 and 30% at 3 years) versus patients with other than bony metastases (100% at 10 years) was statistically different.
authors.affiliation: Istituto di Chirurgia Generale I, Università degli Studi di Padova.
authors.forename: M R
authors.initials: MR
authors.lastname: Pelizzo
authors.forename: B
authors.initials: B
authors.lastname: Busnardo
authors.forename: P
authors.initials: P
authors.lastname: Bernante
authors.forename: M E
authors.initials: ME
authors.lastname: Girelli
authors.forename: D
authors.initials: D
authors.lastname: Nacamulli
authors.forename: A
authors.initials: A
authors.lastname: Toniato
authors.forename: A
authors.initials: A
authors.lastname: Piotto
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D018276:Carcinoma, Medullary / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000401:mortality*
vernacular_title: Carcinoma midollare della tiroide: fattori prognostici.