Local delivery of prostaglandin E1 induces periodontal regeneration in adult dogs.
Formation of cementum, alveolar bone and periodontal ligament was produced in 18 sites on buccal surfaces of mandibular premolars and molars of 11 adult dogs near to sites of local delivery of prostaglandin E1 (PGE) for three weeks. Mineralizing bone and cementum were labelled with fluorescent dyes and polarizing microscopy showed periodontal ligament fibers between these new mineralized tissues. These observations extend recent demonstrations that local application of PGE causes formation of new bone on the mandible and suggest the potential for predictable, site-directed periodontal regeneration.
Marks
S C
SC
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655.
Miller
S C
SC
D000527:Alprostadil / Q000494:pharmacology* / Q000627:therapeutic use; D016301:Alveolar Bone Loss / Q000188:drug therapy*; D000539:Alveolar Process / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D003739:Dental Cementum / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D009805:Odontogenesis / Q000187:drug effects; D010513:Periodontal Ligament / Q000187:drug effects* / Q000502:physiology; D012038:Regeneration / Q000187:drug effects*
D000527:Alprostadil