title: HLA-A*8001 is a member of a newly discovered ancient family of HLA-A alleles.
abstract: A member of a new HLA-A locus family, HLA-A*8001, has been characterized from 3 African-American individuals expressing a unique HLA-A serologic specificity. The HLA-A*8001 sequence is most closely related to alleles of the HLA-A1/3/11 family, although it also contains residues characteristic of the HLA-A2/28, -A9, -A10, and -A19 families. More importantly, the HLA-A*8001 sequence contains four unique nonsynonymous (amino acid replacing) nucleotide substitutions absent from all other primate A locus alleles. In addition, five other nucleotide substitutions, four nonsynonymous and one synonymous (silent), observed only in non-human primate A locus alleles were found. Neighbor-joining tree analysis of HLA-A*8001 supports the notion that the HLA-A*8001 allele is a member of a new HLA-A locus family which was derived from the ancestral A3 lineage but diverged early in the evolution of the HLA-A locus.
authors.affiliation: Department of Pediatrics, Georgetown University Medical Center, Washington, DC.
authors.forename: A G
authors.initials: AG
authors.lastname: Wagner
authors.forename: A L
authors.initials: AL
authors.lastname: Hughes
authors.forename: M L
authors.initials: ML
authors.lastname: Iandoli
authors.forename: D
authors.initials: D
authors.lastname: Stewart
authors.forename: S
authors.initials: S
authors.lastname: Herbert
authors.forename: D I
authors.initials: DI
authors.lastname: Watkins
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
authors.forename: S
authors.initials: S
authors.lastname: Rosen-Bronson
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D044383:Black People / Q000235:genetics; D004247:DNA / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D016133:Polymerase Chain Reaction; D001741:Black or African American
chemical_list: D015234:HLA-A Antigens; D004247:DNA