Electrolyte excretion and sodium intake.
Established essential hypertension is characterized by normal equilibrium between the intake and renal excretion of sodium. Urinary sodium excretion is interrelated with that of other ions, such as potassium and calcium, and that the response of blood pressure to salt ingestion can be conditioned by the simultaneous intake of varying levels of those ions. The authors address three aspects: the correlations between urinary excretion of sodium and calcium and sodium and potassium in a population of untreated essential hypertensive persons, the response of blood pressure during the escape induced by exogenous mineralocorticoid administration in mild essential hypertension, and the effect of intravenous calcium gluconate infusion on sodium excretion and renal function. The first part shows that sodium excretion is closely correlated with that of other ions in essential hypertension, and the second part shows that, to escape from the sodium-retaining effect of a mineralocorticoid, mild hypertensive subjects must have increased blood pressure within or near the cutoff point that defines salt sensitivity. Of interest, the elevation in blood pressure takes place while sympathetic nervous activity is blunted. The third part provides evidence to explain one of the mechanisms by which calcium influences renal function and enhances renal sodium excretion. The intrarenal effects of low doses of calcium are dependent on the renal production of prostaglandins.
Ruilope
L M
LM
Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain.
Lahera
V
V
Araque
A
A
Suarez
C
C
Rodicio
J L
JL
Romero
J C
JC
D009320:Atrial Natriuretic Factor / Q000096:biosynthesis; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D004573:Electrolytes / Q000652:urine*; D006801:Humans; D006973:Hypertension / Q000652:urine*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008901:Mineralocorticoids / Q000494:pharmacology; D012982:Sodium, Dietary / Q000008:administration & dosage*
D004573:Electrolytes; D008901:Mineralocorticoids; D012982:Sodium, Dietary; D009320:Atrial Natriuretic Factor; D002118:Calcium