[Peritoneal dissemination of cecal cancer disappearing in a patient taking 5'-DFUR for 3 years].
A 51-year-old woman presenting with a left ovarian tumor underwent left oophorectomy and hysterectomy with intraperitoneal administration of cisplatin, cyclophosphamide, and 5-fluorouracil on December 13, 1989. Microscopically the tumor was well-differentiated adenocarcinoma. Postoperatively cecal cancer was detected. Laparotomy revealed multiple peritoneal dissemination on March 23, 1990, when palliative ileocecal resection was performed. Microscopy revealed several of the nodules to be adenocarcinoma and the cecal lesion well differentiated adenocarcinoma. The patient was then placed on 5'-deoxy-5-fluorouridine (800 subsequently 600 mg/day). In November, 1991, bright red blood per rectum led to the discovery of rectal cancer. On January 26, 1993, laparotomy revealed rectal tumor invading the bladder but the metastatic nodules on the peritoneum had disappeared. Thus pelvic exenteration was performed. The tumor was well-differentiated adenocarcinoma. The ovarian lesion may have been a metastasis from the cecal cancer, a so-called Krukenberg tumor. The rectal cancer was most likely to be asynchronous cancer. 5'-DFUR seemed effective in remitting the peritoneal dissemination.
Etoh
T
T
Dept. of Surgery, National Shimonoseki Hospital.
Yoshida
J
J
Matoba
N
N
Niiyama
H
H
Maeda
Y
Y
Nagata
T
T
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002430:Cecal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D010051:Ovarian Neoplasms / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D012074:Remission Induction
D000903:Antibiotics, Antineoplastic; D005467:Floxuridine; C025034:doxifluridine