Effect of sulfated polysaccharides on hepatocyte adhesion.
The effects of sulfated polysaccharides on hepatocyte adhesion on the polystyrene dish and fibronectin-coated dish were investigated. Dextran sulfate and synthetic mannopyranan sulfate slightly inhibited hepatocyte adhesion on fibronectin-coated dish, while heparin showed no effect. On the other hand, hepatocyte adhesion on polystyrene dishes was stimulated in the presence of sulfated polysaccharides in the medium.
Kunoú
M
M
Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan.
Akaike
T
T
Hatanaka
K
K
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D016264:Dextran Sulfate / Q000494:pharmacology*; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000166:cytology*; D008351:Mannans / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008351:Mannans; C071637:(1-6)-mannopyranan sulfate; D006493:Heparin; D016264:Dextran Sulfate