Basal extracellular dopamine in the nucleus accumbens during amphetamine withdrawal: a 'no net flux' microdialysis study.
The basal extracellular concentration of dopamine in the nucleus accumbens was quantified using the 'no net flux' microdialysis method, in rats undergoing withdrawal from D-amphetamine. Rats were initially pretreated with saline, or an escalating dose amphetamine regimen known to produce a robust withdrawal syndrome, and extracellular dopamine was quantified 3 or 28 days after the last pretreatment injection. There was no effect of amphetamine pretreatment on the basal extracellular concentration of dopamine in the nucleus accumbens, or on the 'in vivo recovery' of dopamine, estimated by 'no net flux' microdialysis. It is suggested that amphetamine withdrawal is not necessarily accompanied by changes in the basal extracellular concentration of dopamine in the nucleus accumbens.
Crippens
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D
Department of Psychology, University of Michigan, Ann Arbor 48104-1687.
Camp
D M
DM
Robinson
T E
TE
D000818:Animals; D003913:Dextroamphetamine / Q000009:adverse effects*; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D003913:Dextroamphetamine; D004298:Dopamine