title: Cross-protection between species of the Schistosoma haematobium group induced by vaccination with irradiated parasites.
abstract: Mice vaccinated with irradiated cercariae of Schistosoma haematobium, S. bovis and S. margrebowiei showed good levels of resistance (38-62%) against an homologous challenge, and varying degrees of resistance (19-46%), against challenges with closely related species. No protection against S. mansoni was induced by vaccination with any of these species. This restricted cross-protection reflects the close phylogenetic relationship between species of the S. haematobium group and indicates that immunologically important epitopes are conserved within this species complex.
authors.affiliation: Wellcome Research Centre for Parasitic Infections, Department of Biology, Imperial College, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Navarrete
authors.forename: D
authors.initials: D
authors.lastname: Rollinson
authors.forename: A M
authors.initials: AM
authors.lastname: Agnew
mesh_terms: D000818:Animals; D003429:Cross Reactions; D051379:Mice; D008808:Mice, Inbred CBA; D016052:Protozoan Vaccines; D012548:Schistosoma haematobium / Q000528:radiation effects; D012552:Schistosomiasis / Q000276:immunology / Q000517:prevention & control; D012553:Schistosomiasis haematobia / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated