title: Monoclonal cytoplasmic immunoglobulin and pathomorphological reactions in lymph nodes in spontaneous bovine leukemia virus infection.
abstract: Prescapular lymph nodes from 109 cows seropositive to bovine leukemia virus (BLV) were examined for the presence of light chains of bovine immunoglobulin (Ig) kappa or lambda. A variety of reactions were present in prescapular lymph nodes, including B-zonal hyperplasia (23 cases, 21.1%), T-zonal hyperplasia (52 cases, 47.7%), mixed hyperplasia (18 cases, 16.5%), pulp proliferation (six cases, 5.5%), and atrophy (ten cases, 9.2%). In the case of pulp proliferation the immunohistological examination identified only Ig of a single light chain type lambda. The possible relationship of a monoclonal expression of Ig and development of tumorous proliferation is discussed in the study.
authors.affiliation: Department of Pathological Anatomy, University of Veterinary Medicine, Kosice, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Levkut
authors.forename: L
authors.initials: L
authors.lastname: Plank
authors.forename: M
authors.initials: M
authors.lastname: Levkutova
authors.forename: V
authors.initials: V
authors.lastname: Konrád
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D003593:Cytoplasm / Q000276:immunology; D016583:Enzootic Bovine Leukosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007145:Immunoglobulin kappa-Chains / Q000276:immunology*; D007146:Immunoglobulin lambda-Chains / Q000276:immunology*; D001909:Leukemia Virus, Bovine / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains