Effects of endotoxin, interleukin-1 beta and prostaglandin injections on fever response in broilers.
1. The effect of endotoxin, interleukin-1 beta and prostaglandin on fever response was studied in 80 broilers (Hubbard strain). Endotoxin (E. coli, LPS) was injected i.v. (1.5 micrograms/kg) and icv (1.5 micrograms/bird); interleukin-1 (human recombinant IL-1 beta, 80 pg/bird) and prostaglandin E2 (5 micrograms/bird) were injected icv. Indomethacin (10 mg/kg, i.v.) pretreatment was also used before i.v. endotoxin injection. 2. The results showed that indomethacin was able to block the fever response induced by i.v. endotoxin injection, and IL-1 beta and PGE2 were both effective in producing fever when injected icv. These data suggest a prostaglandin-mediated fever response by broilers, and also a strong evidence of the involvement of endogenous pyrogen (interleukin-1) in fever response in birds.
Macari
M
M
Departamento de Morfologia e Fisiologia Animal, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP-Brazil.
Furlan
R L
RL
Gregorut
F P
FP
Secato
E R
ER
Guerreiro
J R
JR
D000818:Animals; D002645:Chickens / Q000502:physiology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D007267:Injections / Q000662:veterinary; D007375:Interleukin-1 / Q000502:physiology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D011201:Poultry Diseases / Q000139:chemically induced / Q000503:physiopathology*; D011453:Prostaglandins / Q000502:physiology*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D011453:Prostaglandins