Prenatal detection of cri du chat syndrome on uncultured amniocytes using fluorescence in situ hybridization (FISH).
Fluorescence in situ hybridization (FISH) with a chromosome-region-specific DNA probe was used prospectively on uncultured amniocyte interphase cells to detect an unbalanced chromosome abnormality that resulted in cri du chat or 5p- syndrome. Confirmation was performed by routine cytogenetics.
Pettenati
M J
MJ
Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157.
Hayworth
R
R
Cox
K
K
Rao
P N
PN
D000328:Adult; D002460:Cell Line; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003410:Cri-du-Chat Syndrome / Q000175:diagnosis* / Q000235:genetics; D015342:DNA Probes; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011296:Prenatal Diagnosis
D015342:DNA Probes