Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization.
The effect of myo-inositol was examined on 5-HT2 receptor mediated facilitation of NMDA depolarization of rat neocortical neurons in vitro. Myo-inositol (1-10 mM) potentiated the 5-HT facilitation, the potentiation increasing linearly with log 5-HT concentration. Myo-inositol also eliminated 5-HT induced heterologous desensitization of muscarinic and alpha 1-adrenergic receptor mediated facilitation. Our findings suggest that 5-HT induced homologous and heterologous desensitization results in part from depleting phosphoinositide substrate.
Rahman
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Faculty of Medicine, Memorial University, St. John's, Nfld, Canada.
Neuman
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RS
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D066298:In Vitro Techniques; D007294:Inositol / Q000494:pharmacology*; D009044:Motor Cortex / Q000166:cytology / Q000187:drug effects; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000166:cytology / Q000187:drug effects
D018340:Receptors, Adrenergic, alpha-1; D011976:Receptors, Muscarinic; D011985:Receptors, Serotonin; D010656:Phenylephrine; D012701:Serotonin; D007294:Inositol; D016202:N-Methylaspartate; D002217:Carbachol