Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility.
Bock
M G
MG
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.
DiPardo
R M
RM
Mellin
E C
EC
Newton
R C
RC
Veber
D F
DF
Freedman
S B
SB
Smith
A J
AJ
Patel
S
S
Kemp
J A
JA
Marshall
G R
GR
D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008954:Models, Biological; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012995:Solubility
D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines