Respiratory mechanics of the horse during the first year of life.
This study investigated the developmental changes in the mechanical properties of the respiratory system in growing horses. Pulmonary mechanics and lung volumes were serially measured in anesthetized foals during the first year of life. Quasi-static pressure-volume curves were generated, and functional residual capacity (FRC) was measured using a closed nitrogen equilibration technique. At birth, chest wall compliance normalized to body weight was substantially less than that reported in other less precocious newborn species, while lung compliance normalized to body weight was similar to values reported for other species. Characteristics of the transition from the neonatal to adult respiratory system in the foal included a decrease in the ratios of chest wall to lung compliance (Cw/CL) and the unstressed volume of the chest wall to TLC, and a constant FRC/TLC throughout most of the study period. The somatic growth of the foal and its respiratory system were uneven processes, with increases in lung volume lagging increases in overall body size.
Koterba
A M
AM
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida Gainesville 32610.
Wozniak
J A
JA
Kosch
P C
PC
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005652:Functional Residual Capacity / Q000502:physiology; D006736:Horses / Q000254:growth & development / Q000502:physiology*; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D015656:Respiratory Mechanics / Q000502:physiology*; D014109:Total Lung Capacity / Q000502:physiology