title: Follicular dendritic cell function and murine AIDS.
abstract: Infection of mice with LP-BM5 elicits an immunodeficiency state referred to as murine acquired immune deficiency syndrome (MAIDS). Shortly after infection, retrovirus particles become associated with follicular dendritic cells (FDC) and this study was undertaken to determine whether retroviruses alter FDC functions. The FDC functions examined included the ability to: (1) retain antigen (Ag) trapped prior to infection; (2) trap new Ag after infection; (3) maintain specific IgG responses; and (4) provide co-stimulatory signals to B cells. Mice were infected with LP-BM5 and the ability of their FDC to trap and retain 125I-Ag (HSA) was assessed. Serum anti-HSA levels were monitored and FDC co-stimulatory activity was indicated by increased B-cell proliferation. HSA trapped on FDC prior to infection began to disappear by 3 weeks and was practically gone by 6 weeks. Serum anti-HSA titres were maintained normally for about 3 weeks after infection and then declined precipitously. The ability of FDC to trap new Ag began to disappear around the second and third week of infection and was markedly depressed by the fourth week. However, FDC recovered from infected mice retained their ability to co-stimulate anti-mu- and interleukin-4 (IL-4)-activated B cells throughout a 5-week period. In short, the ability of FDC to trap and retain specific Ag and maintain specific antibody levels was markedly depressed after retrovirus infection. However, FDC from infected mice continued to provide co-stimulatory signals and these signals may contribute to the lymphadenopathy and splenomegaly characteristic of MAIDS.
authors.affiliation: Department of Microbiology and Immunology, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
authors.forename: A
authors.initials: A
authors.lastname: Masuda
authors.forename: G F
authors.initials: GF
authors.lastname: Burton
authors.forename: B A
authors.initials: BA
authors.lastname: Fuchs
authors.forename: B S
authors.initials: BS
authors.lastname: Bhogal
authors.forename: R
authors.initials: R
authors.lastname: Rupper
authors.forename: A K
authors.initials: AK
authors.lastname: Szakal
authors.forename: J G
authors.initials: JG
authors.lastname: Tew
mesh_terms: D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology / Q000378:metabolism; D000941:Antigens / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology; D013154:Spleen / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D007074:Immunoglobulin G; D012709:Serum Albumin; D010047:Ovalbumin