Creatol, a creatinine metabolite, as a useful determinant of renal function.
Analysis of creatol (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has indicated that CTL is a useful determinant of renal function. The existence itself of serum CTL (s-CTL) could be a diagnostic sign for chronic renal failure (CRF): in all normal subjects, s-CTL was undetectable, but s-CTL was detectable in sera of all patients with CRF (s-Cr: > 2.0 mg/dl). And the s-CTL values increased in proportion to the severity of CRF in such patients. Furthermore, the molar ratio (CTL/Cr) in both urine and serum increased significantly in proportion to the severity of CRF. Our results indicated not only hyperproduction of CTL but also higher oxygen stress in patients according to the progression of CRF. The diagnostic importance of the CTL value and the CTL/Cr ratio are discussed.
Nakamura
K
K
Department of Natural Products Chemistry, Nippon Zoki Pharmaceutical Co. Ltd., Hyogo, Japan.
Ienaga
K
K
Nakano
K
K
Nakai
M
M
Nakamura
Y
Y
Hasegawa
G
G
Sawada
M
M
Kondo
M
M
Mori
H
H
Kanatsuna
T
T
D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D004355:Drug Stability; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D010100:Oxygen / Q000633:toxicity; D012016:Reference Values; D015203:Reproducibility of Results; D012995:Solubility; D013312:Stress, Physiological / Q000097:blood / Q000139:chemically induced / Q000652:urine
C064402:creatol; D003404:Creatinine; D010100:Oxygen