title: Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs.
abstract: In the constant search for new compounds endowed with antitumor activity we have synthesized a series of anthraquinone hydrazones, which can bee seen either as opened-cycle modified anthrapyrazoles or as chromophore-modified anthracenediones. Seven 9,10-anthraquinone monoalkylaminoalkylhydrazones (3c-i) were synthesized from 10,10-dibromoanthrone (4) and a suitable N-alkylhydrazine. The hydrazones were converted into hydrochlorides and tested for their cytotoxic activity against L1210 murine leukemia cells. Two of them possess marginal activity in vitro.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Antonini
authors.forename: P
authors.initials: P
authors.lastname: Polucci
authors.forename: D
authors.initials: D
authors.lastname: Cola
authors.forename: G
authors.initials: G
authors.lastname: Palmieri
authors.forename: S
authors.initials: S
authors.lastname: Martelli
authors.forename: M
authors.initials: M
authors.lastname: Bontemps-Gracz
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D006835:Hydrazones