title: Effective dose in cattle of toxic alkaloids from tall larkspur (Delphinium barbeyi).
abstract: We determined the po toxicity of tall larkspur (Delphinium barbeyi) of known alkaloid composition to cattle. We calculated the effective dose at which the alkaloids methyllycaconitine and 14-deacetylnudicauline, collectively termed total toxic alkaloid, caused collapse and sternal recumbency. The effective dose of total toxic alkaloid that produced sternal recumbency in steers was 11.2 mg/kg bw. Based on this dose, we hypothesize that the LD50 for a po dose of total toxic alkaloids in cattle will be 25 to 40 mg/kg bw.
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84321.
authors.forename: J A
authors.initials: JA
authors.lastname: Pfister
authors.forename: K E
authors.initials: KE
authors.lastname: Panter
authors.forename: G D
authors.initials: GD
authors.lastname: Manners
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives / Q000633:toxicity; D000470:Alkaloids / Q000633:toxicity*; D000821:Animal Feed; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D007928:Lethal Dose 50; D008297:Male; D010939:Plant Poisoning / Q000662:veterinary*; D010947:Plants, Toxic / Q000737:chemistry*
chemical_list: D000470:Alkaloids; C086739:14-deacetylnudicauline; C054634:methyllycaconitine; D000157:Aconitine