Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors.
Alterations of the short arm of chromosome 1 are recurrently found in cytogenetic analysis of malignant gliomas, and deletions of 1p36-p32 region characterize at least the higher-grade tumors, glioblastoma multiforme. Molecular analysis of tumor-derived and normal genomic DNA from 57 cases of gliomas, using a panel of chromosome 1-specific DNA probes showed LOH in 16 tumors. Allelic losses on 1p were primarily restricted to glioblastoma multiforme (2/11) and to tumors with a major oligodendroglial component: grade II oligodendrogliomas (6/6), grade III anaplastic oligodendrogliomas (5/6) and grade II-III mixed oligo-astrocytomas (2/3). Losses for 1q markers were detected in only 1 tumor (glioblastoma multiforme). Our data suggest that anomalies of 1p primarily characterize oligodendrogliomas, whereas they are rare events in astrocytic tumors and indicate that a tumor-suppressor gene on 1p36-p32 is involved in the development of brain tumors with oligodendroglial differentiation.
Bello
M J
MJ
Biomedical Research Institute (CSIC), Madrid, Spain.
Vaquero
J
J
de Campos
J M
JM
Kusak
M E
ME
Sarasa
J L
JL
Saez-Castresana
J
J
Pestana
A
A
Rey
J A
JA
D000483:Alleles; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D005910:Glioma / Q000235:genetics*; D006801:Humans; D009837:Oligodendroglioma / Q000235:genetics*