Combined treatment with growth hormone and luteinizing hormone releasing hormone-analogue (LHRHa) of pubertal children with familial short stature.
We evaluated the 12 month growth of 18 pubertal children with familial short stature randomly assigned to clinical follow-up (group A), GH treatment alone (group B) and GH+LHRH analogue (LHRHa) treatment (group C). Height velocity increased significantly compared to baseline in groups A and B (4.7 +/- 0.4 vs 6.6 +/- 0.6 and 4.4 +/- 0.3 vs 8 +/- 1 respectively), but not in C (5 +/- 0.5 vs 6.5 +/- 0.4). Moreover in group B height and height prognosis standard deviation score SDS) also were higher (-2.2 +/- 0.2 vs -1.7 +/- 0.2 and 1.8 +/- 0.3 vs -1 +/- 0.2, respectively). Comparisons among the groups showed a significant increase in group B vs the other groups of height velocity SDS (3.9 +/- 1.3 vs 0.4 + 1 and 0.3 +/- 0.7) and of height prognosis SDS (-1 +/- 0.2 vs -2.4 +/- 0.3 and -2.4 +/- 0.3). In conclusion, after one-year treatment, GH seems to be more effective in stimulating growth than GH +/- LHRHa, even if studies of longer duration and/or follow-up are needed.
Volta
C
C
Istituto di Clinica Pediatrica, University of Parma, Italy.
Bernasconi
S
S
Tondi
P
P
Salvioli
V
V
Ghizzoni
L
L
Baldini
A
A
Alberini
A
A
Carani
C
C
D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D002648:Child; D004359:Drug Therapy, Combination; D004392:Dwarfism / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013006:Growth Hormone / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007677:Kidney Function Tests; D008111:Liver Function Tests; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011379:Prognosis; D011627:Puberty; D013960:Thyroid Function Tests
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone