title: Gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination.
abstract: The elucidation of the structure of gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase, is described in this paper. By spectroscopic and X-ray crystallographic analyses, the structure of gypsetin has been determined to be 8a,16a-dihydroxy-5a,13a-bis[1,1-dimethylallyl]-[1]benzazolidine [3''' 2''':4'',5'']azolidino[1'',2'':4',5'][1,4]perhydrodiazin[1', 2':1, 5]azolidino[2,3-b]-[1]benzazolidine-7,15-dione.
authors.affiliation: Anorganisch-chemisches Institut, Universität, Heiderberg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Nuber
authors.forename: F
authors.initials: F
authors.lastname: Hansske
authors.forename: C
authors.initials: C
authors.lastname: Shinohara
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Hasumi
authors.forename: A
authors.initials: A
authors.lastname: Endo
mesh_terms: D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D009682:Magnetic Resonance Spectroscopy; D008864:Microsporum / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D010879:Piperazines; C086649:gypsetin; D002785:Sterol O-Acyltransferase