title: Paw preference in mice with callosal defects induced by prenatal gamma irradiation.
abstract: The development of the corpus callosum of male Swiss mice was perturbed by exposure to gamma radiation at embryonic day 16 with total doses of 2 Gy (N = 48) or 3 Gy (N = 26). At adulthood paw preference was studied in these callosal defective animals and in 93 control nonirradiated male Swiss mice. The analysis of directional laterality indicated a populational tendency for right paw use in the 2 Gy group (60%) that was markedly increased in the 3 Gy group (95%). In the 3 Gy group, directional laterality was significantly different from chance in contrast to that observed in normal controls (49%). In the three groups most mice presented a significant individual paw preference. These data are consistent with our hypothesis that the early absence of the corpus callosum disrupts the normal pattern of directional asymmetries.
authors.affiliation: Departamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Brasil.
authors.forename: A C
authors.initials: AC
authors.lastname: Manhães
authors.forename: S L
authors.initials: SL
authors.lastname: Schmidt
authors.forename: E M
authors.initials: EM
authors.lastname: Caparelli-Dáquer
mesh_terms: D061085:Agenesis of Corpus Callosum; D000818:Animals; D005260:Female; D007839:Functional Laterality / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects