title: Assessment of alkaline reflux in children after Nissen fundoplication and pyloroplasty.
abstract: During an eight month period, 22 children less than 15 years of age (mean age of three years and seven months) who underwent operative treatment of gastroesophageal reflux (GER) were selected for study. All were symptomatic and unresponsive to medical therapy. Preoperative evaluation included esophageal pH probe monitoring in 18 patients, gastric isotope emptying study in 18 patients and contrast studies of the upper part of the gastrointestinal tract in ten patients. Four children with severe neurologic disorders who required placement of a feeding gastrostomy tube underwent fundoplication without preoperative evaluation. All 22 patients had GER and 14 had documented delayed gastric emptying (greater than 60 percent residual at 90 minutes) on radionuclide scan with appropriate meal for age. Each child underwent Nissen fundoplication and tube gastrostomy. Sixteen patients also had a modified pyloroplasty with a 2.5 to 4.0 centimeter vertical seromuscular incision on the antrum. When the patients achieved a full feeding schedule (postoperative day range three to 21 days, mean of 6.2 days), they were put on a fast for six hours and an aspirate was obtained from the gastrostomy tube. Analysis of pH and bile acid content served as indicators of alkaline reflux. The six children without pyloroplasty served as the control group. Intragastric pH ranged from 1.91 to 7.00 (mean of 3.71) and bile acid content ranged from 4 to 150 micrometers per liter (mean of 62 micrometers per liter). No significant differences were seen between patients with fundoplication alone and those with fundoplication and pyloroplasty (p = 0.97 for pH; p = 0.66 for bile acid content). Two patients with pyloroplasty showed slight elevation of intragastric bile acid content at the upper limits of normal. At follow-up evaluation from nine to 23 months (mean of 18 months), all patients were asymptomatic, with only two showing rare gagging. Additionally, nine patients have had complete resolution of their pulmonary symptoms. No patients demonstrated diarrhea, gas bloat or dumping. Nissen fundoplication combined with a modified pyloroplasty or "antroplasty" for delayed gastric emptying provides excellent clinical results with minimal demonstrable bile acid reflux and no change in intragastric pH at the one and one-half year follow-up evaluation.
authors.affiliation: Division of Pediatric Surgery, University of California Los Angeles School of Medicine.
authors.forename: T L
authors.initials: TL
authors.lastname: Buchmiller
authors.forename: M
authors.initials: M
authors.lastname: Curr
authors.forename: E W
authors.initials: EW
authors.lastname: Fonkalsrud
mesh_terms: D000293:Adolescent; D001647:Bile Acids and Salts / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005745:Gastric Acidity Determination; D005746:Gastric Emptying; D005748:Gastric Fundus / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000503:physiopathology* / Q000601:surgery*; D005774:Gastrostomy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D011708:Pylorus / Q000601:surgery; D013270:Stomach / Q000601:surgery*
chemical_list: D001647:Bile Acids and Salts