title: Enlarged mediastinal lymph nodes in bronchogenic carcinoma: assessment with dynamic contrast-enhanced MR imaging. Work in progress.
abstract: OBJECTIVE
  To determine whether dynamic contrast material-enhanced magnetic resonance (MR) imaging can help differentiate between malignant and benign mediastinal lymph nodes (MLNs) in bronchogenic carcinoma.
  
  
  METHODS
  Nine patients with biopsy-proved lung carcinoma underwent dynamic contrast-enhanced MR imaging before undergoing thoracic surgery. MR studies included spin-echo, electrocardiographically gated axial and coronal sequences and transaxial gradient-echo breath-hold sequences, which were performed after administration of a bolus of gadoterate meglumine. The enhancement curves were established on the basis of mean signal intensities from regions of interest at the level of tumor and the enlarged MLN. MR images were compared with pathologic specimens obtained at surgical resection.
  
  
  RESULTS
  Metastatic MLNs exhibited their peak enhancement at 60-80 seconds, with a slow decrease until 6 minutes. Granulomatous and anthracotic lymph nodes displayed a slight enhancement, with no peak within 6 minutes (P < .01).
  
  
  CONCLUSIONS
  Dynamic contrast-enhanced MR images may provide informative data about the nature of enlarged MLNs in the preoperative assessment of lung carcinoma. Further studies are needed to investigate its usefulness in clinical practice.
authors.affiliation: Department of Radiology, Hopital Bichat, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Laissy
authors.forename: P
authors.initials: P
authors.lastname: Gay-Depassier
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: M C
authors.initials: MC
authors.lastname: Dombret
authors.forename: G
authors.initials: G
authors.lastname: Murciano
authors.forename: A
authors.initials: A
authors.lastname: Sautet
authors.forename: M
authors.initials: M
authors.lastname: Aubier
authors.forename: Y
authors.initials: Y
authors.lastname: Menu
mesh_terms: D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008482:Mediastinum / Q000473:pathology*; D008536:Meglumine; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine