title: Arias-Stella reaction associated with cervical pregnancy. Report of a case with a cytologic presentation.
abstract: We report the case of an Arias-Stella reaction of the cervix presenting in the cervical smear from a 35-year-old woman who complained of heavy menstrual periods. The smear was originally reported as inconclusive. Colposcopy revealed an abnormal transformation zone extending out of range. Cervical conization was performed. Histologic examination revealed an ectopic cervical pregnancy associated with a cervical Arias-Stella reaction. The cytologic manifestations of the Arias-Stella reaction continue to cause diagnostic confusion with benign lesions and adenocarcinoma. We believe this to be the first reported case of a cervical Arias-Stella reaction associated with a cervical pregnancy; it should alert cytologists to the diagnostic implications.
authors.affiliation: Department of Pathology, Royal Women's Hospital and Gribbles Pathology, Melbourne, Australia.
authors.forename: N J
authors.initials: NJ
authors.lastname: Mulvany
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Ostör
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D002450:Cell Communication / Q000502:physiology; D002584:Cervix Uteri / Q000166:cytology / Q000502:physiology; D003127:Colposcopy; D003937:Diagnosis, Differential; D004717:Endometrium / Q000166:cytology* / Q000502:physiology*; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis / Q000473:pathology*; D014327:Trophoblasts / Q000166:cytology / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology