[Urine levels of soluble interleukin 2 receptor and free light chain immunoglobulins in lupus nephritis].
To find out the relationship between soluble interleukin 2 receptor (sIL-2R) or free light chain immunoglobulins (FLCI) and the activity of lupus nephritis (LN), we determined sIL-2R by ELISA and FLCI by immunodiffusion in the urine of 30 patients with LN and 20 normal persons. We also studied the correlation of sIL-2R levels with clinical and serologic findings over 3 months in the patients. sIL-2R was significantly higher in the active LN patients (160 +/- 108U/ml) than in the normal controls (85 +/- 19U/ml, P < 0.01) and in the inactive LN patients (92 +/- 23 U/ml, P < 0.05), but their serum complements did not change significantly. The positive rate of urine FLCI was higher in the active LN patients than in the inactive LN patients (77% to 15%, P < 0.01) and the normal controls (negative). These results suggest that the urine sIL-2R and FLCI are sensitive markers for disease activity in LN.
Ling
S H
SH
Renal Research Institute, Sun Yat-Sen University of Medical Sciences, Guangzhou.
D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007147:Immunoglobulin Light Chains / Q000652:urine*; D008181:Lupus Nephritis / Q000652:urine*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D007147:Immunoglobulin Light Chains; D015375:Receptors, Interleukin-2