title: Study of the effects of treatment with theophylline on the cognitive process and behaviour of children with bronchial asthma.
abstract: The effects of theophylline (T) on cognitive and emotional aspects were evaluated in nine children with mild bronchial asthma (7-14 years). The study was double blind crossover against placebo (P) for a period of 30 days for each. The children admitted to the study had an average IQ (80-101) and were able to perform pulmonary function studies (PFS). On days 0, 30 and 60 patients were evaluated by psychological tests (Wisc, Bender, Complex Figure A. Rey and Miss Goodenough/Machouver). PPS an T serum levels were performed on days 15 and 45. During the T period all patients had T serum levels greater than 5 mcg/ml (5 to 22). The final evaluation showed no changes in the psychological tests. Behaviour alterations were not reported by the parents. In conclusion, in this group of patients there was no influence of T on the asthmatic children's behavior. These results are in agreement with the recent data published by Schlieper et al. (J. Pediatr. 118: 449-455, 1991).
authors.affiliation: Department of Pediatrics, Escola Paulista de Medicina, São Paulo, Brasil.
authors.forename: C A
authors.initials: CA
authors.lastname: Gil
authors.forename: M L
authors.initials: ML
authors.lastname: Silveira
authors.forename: F J
authors.initials: FJ
authors.lastname: Soares
authors.forename: D
authors.initials: D
authors.lastname: Solé
authors.forename: C
authors.initials: C
authors.lastname: Naspitz
mesh_terms: D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D011581:Psychological Tests; D013806:Theophylline / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D013806:Theophylline