[Morphologic aspects of hemostasis disturbances in meningococcemia in children].
21 children who died from meningococcemia were studied. Shock disturbances of the microcirculation and thrombocytic part of hemostasis prevailed within first hours of the disease in the form of adrenal hemorrhages and brain edema as immediate cause of death. With an increase of the disease duration, aggregational thrombocytopenia, generalized microthrombosis, coagulopathy, fibrinolysis activation resulted in massive hemorrhages in a number of organs and tissues and manifested in the syndrome of polyorganic failure. No significant differences were found depending upon treatment.
Anisimova
Iu N
IuN
Shvets
O L
OL
Guliaev
D V
DV
Tsinzerling
V A
VA
Belebez'ev
G I
GI
D000307:Adrenal Gland Diseases / Q000209:etiology; D001929:Brain Edema / Q000209:etiology; D002675:Child, Preschool; D006402:Hematologic Diseases / Q000209:etiology* / Q000473:pathology*; D006470:Hemorrhage / Q000209:etiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007223:Infant; D008589:Meningococcal Infections / Q000097:blood / Q000150:complications* / Q000473:pathology; D009102:Multiple Organ Failure / Q000209:etiology; D012772:Shock, Septic / Q000209:etiology
Morfologicheskie aspekty narusheniĭ gemostaza pri meningokoktsemii u deteĭ.