title: Pulmonary sequestration with primary blastomycosis. Failure of ketoconazole therapy after resection.
abstract: Infection with Blastomyces dermatitidis developed in a girl with occult pulmonary sequestration. Six months after resection, while receiving ketoconazole, she developed an abscess due to B dermatitidis over the scar from thoracotomy, with a sinus tract to the eighth rib. This was successfully managed with débridement, rib resection, and amphotericin B. Contiguous bone involvement should be suspected in sequestra infected with this organism; débridement and therapy with amphotericin B might be indicated.
authors.affiliation: Department of Pediatrics, University of Louisville School of Medicine, Ky.
authors.forename: R A
authors.initials: RA
authors.lastname: Serneels
authors.forename: G S
authors.initials: GS
authors.lastname: Marshall
authors.forename: J
authors.initials: J
authors.lastname: Wampler
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: G
authors.initials: G
authors.lastname: Adams
mesh_terms: D001759:Blastomycosis / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D001998:Bronchopulmonary Sequestration / Q000150:complications* / Q000601:surgery; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D012008:Recurrence; D017211:Treatment Failure
chemical_list: D007654:Ketoconazole