title: Effects of tetrahydroberberine on isoproterenol-stimulated mitochondrial 45Ca uptake in rabbit myocardia.
abstract: Cardiac mitochondria of rabbit was prepared by differential centrifugation. Tetrahydroberberine (THB) 10 mumol/L inhibited isoproterenol 1 mumol/L induced 45Ca uptake in the mitochondria by 48.58%. The inhibition is concentration-dependent and may play an important role in the protection of mitochondrial function in cardiac ischemia and reperfusion injury.
authors.affiliation: Department of Pharmacology, Tongji Medical University, Wuhan.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: D X
authors.initials: DX
authors.lastname: Li
mesh_terms: D000818:Animals; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits
chemical_list: D002132:Calcium Radioisotopes; D001599:Berberine; D007545:Isoproterenol; D002118:Calcium; C004645:canadine