Dietary level of maize oil affects growth and lipid composition of Walker 256 carcinosarcoma.
Walker 256 carcinosarcoma cells (1 x 10(4)) were injected into the right thigh muscle of Sprague-Dawley rats (125 g) consuming isoenergetic (200 g fat/kg) diets containing 20, 100 and 200 g maize oil/kg and 180, 100 or 0 g hydrogenated lard/kg respectively. Ten rats from each dietary regimen were killed every 4th day. Tumours grew rapidly from day 0 to day 8 post-transplant regardless of dietary regimen. However, after 8 d more tumours regressed and there were fewer deaths in animals fed on 200 g maize oil/kg compared with animals fed on 20 or 100 g maize oil/kg. Linoleic acid (LA) levels were higher in phospholipids (PL) of growing tumours than in regressing tumours whereas arachidonic acid levels in PL were lower in growing tumours indicating a possible alteration in the desaturation and elongation of LA. Serum prostaglandin E2 levels were slightly lower in rats with regressing tumours than in rats with growing tumours.
Black
J M
JM
Lipids Research Group, University of California, Davis 95616.
Nesheim
M C
MC
Kinsella
J E
JE
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002279:Carcinoma 256, Walker / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D003314:Corn Oil / Q000008:administration & dosage*; D004032:Diet; D015232:Dinoprostone / Q000097:blood; D008041:Linoleic Acids / Q000378:metabolism; D050356:Lipid Metabolism; D009365:Neoplasm Regression, Spontaneous; D009368:Neoplasm Transplantation; D010743:Phospholipids / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D001095:Arachidonic Acids; D008041:Linoleic Acids; D010743:Phospholipids; D003314:Corn Oil; D015232:Dinoprostone