Characterization of a novel leucocyte activation antigen recognized by the antibody CMRF-37.
We describe a novel activation antigen recognized by the monoclonal antibody CMRF-37, which is absent or only weakly expressed on resting cells but is rapidly induced on T cells, B cells and monocytes following stimulation. Its kinetics of expression (12-24 h after the addition of the inductive signal) indicate that it is an early activation antigen. The cellular distribution and expression kinetics of the CMRF-37 antigen differ from other known activation antigens and as such should be a useful marker of human leucocyte activation.
Daish
A
A
Haematology/Immunology Research Group, Christchurch Hospital, New Zealand.
Hock
B D
BD
Hart
D N
DN
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005434:Flow Cytometry; D006801:Humans; D037181:Lectins, C-Type; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014407:Tumor Cells, Cultured; D000099192:CD69 Antigens
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D016207:Cytokines; D037181:Lectins, C-Type; D008934:Mitogens; D000099192:CD69 Antigens