title: Activity of sparfloxacin against Mycobacterium leprae measured by the proportional bactericidal test.
abstract: The activity of 25 mg/kg and 50 mg/kg sparfloxacin was measured against Mycobacterium leprae in normal (immunocompetent) mouse foot pads by the proportional bactericidal test. This was compared with the action of 25, 50, and 150 mg/kg ofloxacin by the same method. Sparfloxacin, at both concentrations, was found to be strongly bactericidal by this method, comparable to 150 mg/kg ofloxacin.
authors.affiliation: Department of Medical Microbiology, St. George's Hospital Medical School, London, U.K.
authors.forename: R D
authors.initials: RD
authors.lastname: McDermott-Lancaster
authors.forename: D K
authors.initials: DK
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D024841:Fluoroquinolones; D007918:Leprosy / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use; D015363:Quinolones / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015242:Ofloxacin; C061363:sparfloxacin