Stimulation of human scalp papilla cells by epithelial cells.
Evidence for the growth stimulatory properties of human keratinocyte-derived conditioned medium on human scalp dermal papilla cells and a mouse fibroblast cell line (Balb/c 3T3) is presented. There was no mitogenic effect on human keratinocytes. This conditioned medium induced a 2-5-fold increase in mitogenic activity in papilla cells relative to sham-conditioned medium as measured by 3H-thymidine incorporation. The papilla cell growth-stimulating activity of the conditioned medium was sensitive to heat, and from size exclusion the molecular weight was greater than 3000 Da.
Warren
R
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Procter and Gamble Company, Sharon Woods Technical Center, Cincinnati, OH 45241-2422.
Wong
T K
TK
D016475:3T3 Cells / Q000502:physiology; D000818:Animals; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000737:chemistry; D004847:Epithelial Cells; D006133:Growth Substances / Q000302:isolation & purification / Q000502:physiology; D006197:Hair / Q000166:cytology* / Q000254:growth & development*; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D051379:Mice; D015398:Signal Transduction / Q000502:physiology
D017077:Culture Media, Conditioned; D006133:Growth Substances