[Meta-analysis of smoking and lung cancer in China: combined analysis of fifteen case-control studies].
In the present paper, 15 case-control studies on the relation between smoking and lung cancer in China were analyzed by means of Meta-analysis method. The cumulative cases and controls were 5703 and 5669, respectively. Peto's model and Der Simonian and Nan Laird model were applied to process data. The pooled OR (smoking vs no smoking) was 3.01 (95% CI: 2.63-3.46) in males and 2.32 (95% CI: 2.02-2.66) in females. The PAR was 56.84% in males and 33.10% in females. There was significant dose-response relation between the amount of smoking, the years of smoking, the age at start of smoking and the OR for developing lung cancer. The pooled OR of squamous carcinoma was 4.79 (95% CI: 4.02-5.70), PAR was 65.44%. The pooled OR of adenocarcinoma was 1.02 (95% CI: 0.87-1.20), PAR was 0.99%.
Zhao
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Department of Epidemiology, Shanghai Medical College.
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D016017:Odds Ratio; D012907:Smoking / Q000009:adverse effects*