title: Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis.
abstract: Interactions between clarithromycin and biofilms formed by Staphylococcus epidermidis were investigated by using a clarithromycin-resistant strain. Treatment of the colonization with a relatively low concentration of clarithromycin resulted in the eradication of slime-like structure and a decrease in the quantity of hexose. Another result was increased penetration of antibiotics through the biofilm of S. epidermidis.
authors.affiliation: Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ajiki
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: T
authors.initials: T
authors.lastname: Yokota
mesh_terms: D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005898:Glass; D006601:Hexoses / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D013055:Spectrophotometry, Infrared; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: D006601:Hexoses; D017291:Clarithromycin