Does bicuculline antagonize NMDA receptors? Further evidence in the rat striatum.
In two areas of the rat striatum, the in vitro N-methyl-D-aspartate (NMDA, 50 microM)-evoked release of [3H]dopamine was studied in the presence of bicuculline (5 and 50 microM), an antagonist of GABAA receptors. The responses observed with the higher concentration (50 microM) is compatible with an antagonistic activity of bicuculline on NMDA receptor, as recently reported by Wright and Nowak.
Krebs
M O
MO
Chaire de Neuropharmacologie, INSERM U114, Collège de France 11, Paris.
Kemel
M L
ML
Gauchy
C
C
Desban
M
M
Glowinski
J
J
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D058787:GABA-A Receptor Antagonists; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D058787:GABA-A Receptor Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D004298:Dopamine; D001640:Bicuculline