[The characteristics of the changes in the blood enzyme activity of patients with acute alcoholic psychoses].
The serum activity of alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase, gamma-glutamyl transferase and creatinine kinase was studied in 81 patients with chronic alcoholism and 31 patients with alcoholic psychoses. Eighty-one healthy apparently non-drinkers served as a control group. It is concluded that when acute alcoholic psychoses develop, patients with chronic alcoholism display a simultaneous increase in the activity of enzymes releasing from damaged muscular and hepatic tissues. This makes the application of a number of the diagnostic criteria developed in classical clinical enzymology impossible. The phenomenon of concurrent increases in the activity of creatine kinase, aspartate aminotransferase and glutamate dehydrogenase by 4 times or more has been proposed to be used as a criteria for identifying alcoholic psychosis in alcoholics.
Iakovchenko
V A
VA
Makarovskiĭ
V V
VV
Moshkin
A V
AV
D000208:Acute Disease; D000328:Adult; D000437:Alcoholism / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D004796:Clinical Enzyme Tests; D004798:Enzymes / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011604:Psychoses, Alcoholic / Q000175:diagnosis*
D015415:Biomarkers; D004798:Enzymes
Osobennosti izmeneniia aktivnosti fermentov v krovi bol'nykh ostrymi alkogol'nymi psikhozami.