title: The penetration of rufloxacin into sites of potential infection in the respiratory tract.
abstract: The concentrations of rufloxacin in the bronchial mucosal, pulmonary epithelial lining fluid and alveolar macrophages were determined in specimens obtained at fibreoptic bronchoscopy. A single oral dose of rufloxacin 400 mg was administered and the samples obtained in the following 72 h. The mean peak serum concentration was 3.56 mg/L, yet the agent was concentrated 1.8-fold in bronchial mucosa, 21.6-fold in alveolar macrophages and 7.7-fold in epithelial lining fluid (as measured by AUC ratios).
authors.affiliation: Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: J
authors.initials: J
authors.lastname: Andrews
authors.forename: B P
authors.initials: BP
authors.lastname: Imbimbo
authors.forename: I
authors.initials: I
authors.lastname: Greaves
authors.forename: D
authors.initials: D
authors.lastname: Honeybourne
mesh_terms: D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid; D004848:Epithelium / Q000378:metabolism; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008168:Lung / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D015363:Quinolones / Q000097:blood / Q000493:pharmacokinetics*; D012141:Respiratory Tract Infections / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C060328:rufloxacin