title: Reproductive failure in a patient with neurofibromatosis-Noonan syndrome.
abstract: We report on a 39-year-old man with neurofibromatosis-Noonan syndrome and long-standing infertility. Comprehensive testing did not uncover any significant endocrine abnormalities, but the testicular seminiferous epithelium was found to be severely compromised. While the occasional association of neurofibromatosis with signs of Noonan syndrome has been reported, reproductive failure has not been previously described in this condition.
authors.affiliation: Institutes of Reproductive Medicine, Münster, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Meschede
authors.forename: U G
authors.initials: UG
authors.lastname: Froster
authors.forename: F
authors.initials: F
authors.lastname: Gullotta
authors.forename: E
authors.initials: E
authors.lastname: Nieschlag
mesh_terms: D000328:Adult; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D009634:Noonan Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D009845:Oligospermia / Q000209:etiology*; D013737:Testis / Q000002:abnormalities
chemical_list: D006728:Hormones