Hereditary warfarin resistance.
We report on a case of hereditary warfarin resistance in a 27-year-old black man. Hereditary warfarin resistance is a rare disorder transmitted as autosomal dominant. It should be suspected in patients who require high doses of warfarin, achieve high plasma warfarin levels, and have a normal plasma warfarin clearance. Treatment includes either high dose warfarin or heparin (subcutaneous).
Diab
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Department of Medicine, Nassau County Medical Center, East Meadow, NY 11554.
Feffer
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D000328:Adult; D004351:Drug Resistance / Q000235:genetics*; D005799:Genes, Dominant; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*; D014812:Vitamin K / Q000502:physiology; D014859:Warfarin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D014812:Vitamin K; D014859:Warfarin; D006493:Heparin