title: [The implantation of a heterologous prosthesis in reparative abdominal-thoracic surgery. Experience with the use of clindamycin in preventing prosthesis-related infection].
abstract: The authors point out how infection of heterologous prosthesis, widely used in surgery, can be a dramatic event. On the other hand, antibiotic prophylaxis is difficult because of the difference between "in vitro" and "in vivo" activity of many antibiotics, due to the production, by many bacteria, of the so-called glycocalyx. This would allow bacteria to clump and adhere to many surfaces, forming micro-colonies, causing delay in phagocytosis, and reducing the efficacy of antibiotics. On the basis of their, although limited, experience, the authors suggest, for the prophylaxis of prosthesis infection, the use of antibiotics such as clindamycin, able to reduce glycocalyx production.
authors.affiliation: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi di Ferrara.
authors.forename: A
authors.initials: A
authors.lastname: Sortini
authors.forename: M
authors.initials: M
authors.lastname: Ortolani
authors.forename: S
authors.initials: S
authors.lastname: Occhionorelli
authors.forename: M
authors.initials: M
authors.lastname: Santini
authors.forename: G
authors.initials: G
authors.lastname: Cerreta
authors.forename: G
authors.initials: G
authors.lastname: Brunelli
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery*; D002981:Clindamycin / Q000627:therapeutic use*; D006552:Hernia, Inguinal / Q000601:surgery; D006555:Hernia, Ventral / Q000601:surgery; D006801:Humans; D011292:Premedication; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D012008:Recurrence; D013526:Surgical Mesh / Q000009:adverse effects*; D013903:Thoracic Surgery / Q000379:methods*
chemical_list: D002981:Clindamycin
vernacular_title: Impianto di protesi eterologa nella chirurgia riparativa addomino-toracica. Esperienza con l'uso della clindamicina nella profilassi dell'infezione protesica.