HLA antigens in Arab children with steroid-responsive nephrotic syndrome.
Forty-eight Arab patients with steroid-responsive childhood nephrotic syndrome were studied for the frequency of HLA-A, -B, -C and -DR antigens. HLA-DR7 was significantly increased in the patient group (63% vs. 28%, P = 0.0002) confirming reports of a DR7 association in other ethnic groups and indicating a universal association with this antigen. HLA-CW6 was also significantly increased (44% vs. 21%, P corr. = 0.042). HLA-DQW1 was significantly reduced in the patients (29% vs. 57%, P corr. = 0.012) as was HLA-CW4 (6% vs. 24%, P corr. = 0.042).
Zaki
M
M
Department of Paediatrics, Farwania Hospital, Kuwait.
Daoud
A S
AS
al Saleh
Q A
QA
al Najedi
A K
AK
White
A G
AG
D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005938:Glucocorticoids / Q000627:therapeutic use*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D016130:Immunophenotyping; D007730:Kuwait; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000208:ethnology / Q000276:immunology*
D005938:Glucocorticoids; D006680:HLA Antigens