Frequent overexpression of p53 in dysgerminoma of the ovary.
The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-1. All the tumors exhibited overexpression of p53 protein. Immunoreactive tumor cell nuclei amounted to more than 50% in 2 tumors, 10-50% in 2 tumors, and less than 10% in 3 tumors. No relationship was found between tumor stage and the degree of p53 expression. Overexpression of p53 thus appears to be very common in dysgerminoma, as it is in epithelial ovarian cancer.
Dietl
J
J
Department of Obstetrics and Gynecology, University of Tübingen, FRG.
Horny
H P
HP
Kaiserling
E
E
D000293:Adolescent; D000328:Adult; D004407:Dysgerminoma / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53