[Effect of chitosan sulfates on lipoprotein lipase activity].
Effect of commercially available preparations of chitosan sulfate on the total lipolytic activity was studied in rabbit blood. Chitosan sulfates, administered per os or intravenously, proved to be highly effective activators of lipolytic enzymes. The most distinct efficiency exhibited preparations with molecular mass of 60-120 x 10(3) and the rate of sulfation 1.20-1.35. After administration of the chitosan sulfates into hyperlipidemic rats a decrease in blood plasma VLDL and increased HDL content were observed.
Solov'eva
M A
MA
Gorbacheva
I N
IN
Vikhoreva
G A
GA
Gal'braĭkh
L S
LS
Ryzhenkov
V E
VE
D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D004789:Enzyme Activation; D008071:Lipoprotein Lipase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D011817:Rabbits
D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D002686:Chitin; D048271:Chitosan; D008071:Lipoprotein Lipase
Vliianie sul'fatov khitozana na aktivnost' lipoproteinlipazy.