title: Adherence of Candida albicans germ tubes to murine tissues in an ex vivo assay.
abstract: Adhesion of Candida albicans germ tubes to murine tissues was examined. An ex vivo assay previously employed to examine adhesion of yeast cells of C. albicans was adapted for use with germ tubes. Binding of germ tubes to kidney, liver, spleen, and lymph node tissues was found to occur throughout the tissue section, with little morphologic specificity. In general, more organisms adhered to spleen and lymph node tissues than to kidney and liver tissues. Observation of adhesion with scanning organisms adhered to spleen and lymph node tissues than to kidney and liver tissues. Observation of adhesion with scanning electron microscopy showed three germ tube-tissue interactions described as loose, tight, or embedded.
authors.affiliation: Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock 79430.
authors.forename: J L
authors.initials: JL
authors.lastname: López-Ribot
authors.forename: M N
authors.initials: MN
authors.lastname: Vespa
authors.forename: W L
authors.initials: WL
authors.lastname: Chaffin
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D007668:Kidney / Q000382:microbiology*; D008099:Liver / Q000382:microbiology*; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000382:microbiology