A study of the association between hormone replacement therapy, smoking and the occurrence of myocardial infarction in women.
The initial results are reported of a case-control study undertaken on the VAMP multi-purpose database and designed to estimate the risk for first-time occurrence of myocardial infarction in users of hormone replacement therapy (HRT). The findings currently available relate to the computerized data and show 2- to 5-fold increases in risk in smokers and those with diabetes mellitus, hypertension or hyperlipidaemia. With any form of HRT, a non-significant protective effect [adjusted odds ratio = 0.83 with 95% CI (confidence intervals) of 0.66-1.03, p = 0.089] has been shown. However, the protective effect of HRT in the data available to date appears to be confined to non-smokers in whom the odds ratio in the absence of other risk factors is 0.70 (95% CI of 0.49-1.00). The comparable odds ratio in smokers is 1.05 (95% CI of 0.71-1.53). These results should be interpreted with caution as smoking status was unknown for about half of the subjects and was more complete among the cases than controls.
Mann
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Chukwujindu
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Chanter
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D016022:Case-Control Studies; D016208:Databases, Factual; D048909:Diabetes Complications; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*