[beta-lactamase activity in sputum of patients with community-acquired lower respiratory tract infections].
beta-Lactamase production and activities in sputa of patients with community-acquired lower respiratory tract infections (LRTI) were determined and following results were obtained: 1) Suspected causative organisms frequently isolated were H. influenzae and Streptococcus pneumoniae. Similar results were previously reported. 2) Various beta-lactamase producing indigenous bacteria were detected. In many cases these indigenous beta-lactamase producing strains were isolated even when suspected causative bacteria were not beta-lactamase producers. 3) beta-Lactamase activities were detected from 61.5% of the sputa tested. Remaining activities of antibiotics added to the sputa were highly correlated with detection of beta-lactamases produced by suspectedly causative and indigenous strains and with presence of beta-lactamase activities in the sputa. Sulbactam/cefoperazone was stable in sputa than other antibiotics tested. 4) We concluded that the beta-lactamase produced by indigenous strains can be one of the factors of indirect pathogenicity in the community-acquired LRTI.
Deguchi
K
K
Section of Studies, Tokyo Clinical Research Center.
Yokota
N
N
Koguchi
M
M
Suzuki
Y
Y
Fukayama
S
S
Ishihara
R
R
Oda
S
S
Tanaka
S
S
Nakane
Y
Y
Fukumoto
T
T
D002438:Cefoperazone / Q000378:metabolism; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D010878:Piperacillin / Q000378:metabolism; D012141:Respiratory Tract Infections / Q000201:enzymology* / Q000382:microbiology / Q000635:transmission; D013183:Sputum / Q000201:enzymology*; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013407:Sulbactam / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism*
D002438:Cefoperazone; D001618:beta-Lactamases; D013407:Sulbactam; D010878:Piperacillin