A new antivenom to treat eastern coral snake (Micrurus fulvius fulvius) envenoming.
An Fab based ovine antivenom has been prepared and compared both in vitro and in vivo with two commercial preparations. The product was found to be at least four times more effective on a weight basis. The increased potency, combined with the low incidence of side-effects associated with ovine Fab, should result in a safer, more effective antivenom.
Rawat
S
S
Therapeutic Antibodies Inc., St. Bartholomew's Hospital Medical College, London, U.K.
Laing
G
G
Smith
D C
DC
Theakston
D
D
Landon
J
J
D000818:Animals; D000997:Antivenins / Q000096:biosynthesis* / Q000276:immunology / Q000302:isolation & purification; D004546:Elapid Venoms / Q000276:immunology* / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D012756:Sheep
D000997:Antivenins; D004546:Elapid Venoms; C053972:micrurus venom