Effects of tetrahydroberberine on isoproterenol-stimulated mitochondrial 45Ca uptake in rabbit myocardia.
Cardiac mitochondria of rabbit was prepared by differential centrifugation. Tetrahydroberberine (THB) 10 mumol/L inhibited isoproterenol 1 mumol/L induced 45Ca uptake in the mitochondria by 48.58%. The inhibition is concentration-dependent and may play an important role in the protection of mitochondrial function in cardiac ischemia and reperfusion injury.
Zhou
J
J
Department of Pharmacology, Tongji Medical University, Wuhan.
Li
D X
DX
D000818:Animals; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits
D002132:Calcium Radioisotopes; D001599:Berberine; D007545:Isoproterenol; D002118:Calcium; C004645:canadine