[Hemophagocytic syndrome in a patient with immunoblastic lymphadenopathy-like T-cell lymphoma].
We report a 70-year-old male case of immunoblastic lymphadenopathy-like T-cell lymphoma (IBL-T) complicated by hemophagocytic syndrome (HPS) as a terminal event. The patient experienced fever and systemic lymphadenopathy after 22 months' remission of IBL-T. He developed acute hepatic failure and consumption coagulopathy rapidly, and died on the 7th hospital day. Serum levels of cytokines, including interferon-gamma and tumor necrosis factor-alpha, were elevated. Postmortem bone marrow aspirate showed a marked proliferation of benign-looking macrophages, some of which phagocytized erythrocytes and platelets. Because there were no preceding viral or bacterial infections, the HPS of this case was assumed to be associated with IBL-T at relapse.
Kawabata
Y
Y
Third Department of Internal Medicine, Akita University School of Medicine.
Chubachi
A
A
Miura
I
I
Saito
M
M
Watanuki
T
T
Miura
A B
AB
D000368:Aged; D001854:Bone Marrow Cells; D016207:Cytokines / Q000097:blood; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D012008:Recurrence
D016207:Cytokines