Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney.
The SA gene is a novel gene of yet unknown function recently implicated in blood pressure regulation in rodent models of genetic hypertension. In this study we have located the human homologue of the SA gene to chromosome 16p13.11, by a combination of fluorescence in-situ hybridization and analysis of somatic cell hybrids carrying different segments of chromosome 16. This should facilitate investigation of its role in the genetic tendency to hypertension in humans. Increased expression of the gene in the kidney may be the mechanism through which some allelic variants of the gene raise blood pressure in rodent models. In this study we also demonstrate that the SA gene is expressed in human kidneys.
Samani
N J
NJ
Department of Medicine, University of Leicester, UK.
Whitmore
S A
SA
Kaiser
M A
MA
Harris
J
J
See
C G
CG
Callen
D F
DF
Lodwick
D
D
D000818:Animals; D001794:Blood Pressure; D002460:Cell Line; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002885:Chromosomes, Human, Pair 16; D003066:Coenzyme A Ligases; D015870:Gene Expression; D006801:Humans; D006973:Hypertension / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D007668:Kidney / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012377:Rodentia
D011506:Proteins; D012333:RNA, Messenger; C081817:Acsm3 protein, rat; D003066:Coenzyme A Ligases