Ocular absorption and distribution of bendazac after topical administration to rabbits with different vehicles.
Ocular and systemic absorption of bendazac was investigated after topical administration to rabbits of 0.5% solutions of bendazac lysine in different polysaccharide vehicles. The results show that the drug is absorbed into the retina-choroid via an extracorneal, or sclero-conjunctival route; the iris and the ciliary body are presumably supplied via both the transcorneal and the extracorneal pathways. The extent of absorption via the extracorneal route is not related to vehicle viscosity but rather to the chemical features of vehicle. The transcorneal penetration appears to be hindered by the binding of the drug to corneal tissues.
Romanelli
L
L
Institute of Pharmacology and Pharmacognosy, University of Rome La Sapienza, Italy.
Valeri
P
P
Morrone
L A
LA
Pimpinella
G
G
Graziani
G
G
Tita
B
B
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D065347:Hypromellose Derivatives; D007191:Indazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011134:Polysaccharides; D011817:Rabbits; D014018:Tissue Distribution; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011134:Polysaccharides; D065347:Hypromellose Derivatives; D008747:Methylcellulose; C000123:bendazac