Hyperprolactinaemia and reproductive failure.
63 cases of hyperprolactinaemia (55 women and 8 men) were studied. Of the 55 women, 39 presented with infertility, while five were unmarried and had menstrual abnormalities. All eight men were partners of an infertile union. The principal modes of presentation of hyperprolactinaemia in women were infertility (74.6%) and menstrual disorders (27.6%). Galactorrhoea was evident in 28.6% and 10.7% had headache. There was no significant correlation between the level of prolactin and the duration of amenorrhoea. Changes in pituitary gonadotrophin levels were observed in 30.2% of cases, the common feature being an elevated LH level. Treatment with bromocriptine restored normal cycles, and the incidence of pregnancies was 38.5%. 14 normal infants were born and one patient miscarried.
Gunaratne
M
M
University of Peradeniya, Sri Lanka.
D000293:Adolescent; D000328:Adult; D001971:Bromocriptine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D007247:Infertility, Female / Q000209:etiology*; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D008599:Menstruation Disturbances / Q000209:etiology; D008875:Middle Aged; D011388:Prolactin / Q000097:blood / Q000187:drug effects; D016896:Treatment Outcome
D006065:Gonadotropins, Pituitary; D001971:Bromocriptine; D011388:Prolactin