Genotoxicity of the phosphoramidate agent tabun (GA).
Five mutagenicity tests were performed on Agent GA (Tabun, phosphoramidocyanidic acid, dimethyl-, ethyl ester) as part of a program to demilitarize chemical warfare agents. GA was mutagenic in Salmonella spp. assays with S-9 and it was a direct-acting mutagen to mouse lymphoma cells. GA did not promote unscheduled DNA synthesis in rat hepatocytes; it induced sister chromatid exchanges in mouse cells in vitro but in vivo. The conclusion that GA is a weakly acting mutagen is supported by the fact that it was mutagenic in only three of the five assays, and that increases in mutagenicity were often less than 2-fold the controls and occurred near toxic levels.
Wilson
B W
BW
Department of Avian Sciences, University of California, Davis 95616-5224.
Kawakami
T G
TG
Cone
N
N
Henderson
J D
JD
Rosenblatt
L S
LS
Goldman
M
M
Dacre
J C
JC
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D005260:Female; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010755:Organophosphates / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D009153:Mutagens; D010755:Organophosphates; D004247:DNA; C009374:tabun