Influence of acetylsalicylic acid on a Listeria monocytogenes infection.
The influence of acetylsalicylic acid (ASA, CAS 50-78-2) on the Listeria monocytogenes infection in balb/c mice was investigated. One day prior to lethal or sublethal infection, balb/c mice were treated intravenously with therapeutic concentrations of ASA alone or ASA in combination with murine recombinant interferon gamma, a lymphokine produced by T-helper cells. Three days post-infection, parasite burdens of spleen and liver were determined by the colony-forming unit assay. It was shown that the prophylactic application of ASA in a concentration of 5 mg/kg body weight resulted in a more than 10-fold reduction of viable Listeria monocytogenes in spleen and liver of balb/c mice. In addition, the combination of a suboptimal dosage of interferon gamma with ASA resulted in a significantly higher survival rate compared to the untreated controls.
Hockertz
S
S
Fraunhofer Institute for Toxicology, Hannover, FRG.
Paulini
I
I
Rogalla
K
K
Schettler
T
T
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D005260:Female; D007275:Injections, Intravenous; D007371:Interferon-gamma / Q000627:therapeutic use; D008088:Listeriosis / Q000382:microbiology / Q000517:prevention & control*; D008099:Liver / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins; D013154:Spleen / Q000382:microbiology
D011994:Recombinant Proteins; D007371:Interferon-gamma; D001241:Aspirin