title: [Quantitative structure-hypoglycemic activity relationships of some thiazolidine and imidazolidine-2,4-diones].
abstract: Quantitative structure-activity relationships are described for twenty six title compounds. Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The aim of the present paper is to investigate the contribution of the different substituents in the biological activity. The application of Fujita-Ban and Hansch models has shown that lipophilic and electronic parameters seem to be the best explanation of variance of biological data.
authors.affiliation: Département d'Antibiotiques, Université Fédérale de Pernambuco, Cidade Universitaria, Récife, PE, Brésil.
authors.forename: J G
authors.initials: JG
authors.lastname: de Lima
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: I da R
authors.initials: Ida R
authors.lastname: Pitta
authors.forename: M T
authors.initials: MT
authors.lastname: Catanho
authors.forename: M
authors.initials: M
authors.lastname: Perrissin
authors.forename: C
authors.initials: C
authors.lastname: Luu-Duc
mesh_terms: D000818:Animals; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D007093:Imidazoles; D013844:Thiazoles
vernacular_title: Relations quantitatives structure-activité hypoglycémiante de quelques thiazolidine- et imidazolidine-2,4-diones.