Vasoactive intestinal peptide stimulates the growth of rat hepatoma cells in vitro.
Using tetrazolium colorimetric assay (MTT assay) and cell counting methods, the effect of vasoactive intestinal peptide (VIP) on the growth of cultured rat hepatoma FSK-7902 cells was investigated. The results showed that VIP obviously stimulated the proliferation of the rat hepatoma cells. The growth promoting effect increased with VIP concentration. Exposure to VIP for 12 h followed by removal of the peptide resulted in sustained growth promotion for several days.
Huang
X
X
Department of Histology and Embryology, Fourth Military Medical University, Xi'an.
Zhang
Y
Y
Bu
Y
Y
Su
H
H
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide