HTLV-1 Tax: regulation of gene expression and disease.
The human T cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes adult T cell leukemia and the neurological disorder tropical spastic paraparesis. Pathology apparently results from the activities of the Tax protein, which trans-activates the expression of viral and cellular genes by binding to various enhancer-binding proteins needed for transcription. This ultimately results in cell transformation, immortalization and disease.
Yoshida
M
M
Dept of Cellular and Molecular Biology, University of Tokyo, Japan.
D001483:Base Sequence; D015967:Gene Expression Regulation, Viral; D016355:Genes, pX / Q000235:genetics*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D008969:Molecular Sequence Data