title: [The effect of Proglicem in patients with an organic hyperinsulinism syndrome].
abstract: BACKGROUND
  Organic hyperinsulinism is treated as a rule conservatively with diazoxide (Proglicem) which has a hyperglycaemic effect. In some patients, however, treatment fails and severe hypoglycaemia persists. The objective of the present investigation was to find simple criteria for evaluation of the aptness (effectiveness) of this treatment.
  
  
  RESULTS
  In 11 patients with a confirmed insulinoma Proglicem was administered for five days (3 mg/kg body weight) and serum insulin and the blood sugar level as well as their ratio (IRI:G) were followed-up. In eight patients the IRI/G coefficient declined from 10.5 +/- 7.7 to 5.8 +/- 2.9 (p < 0.001); only in three patients the coefficient increased from 4.6 +/- 2.9 to 14.9 +/- 12.3 (p < 0.001). Coefficient "k" from the modified Bergman model for the intravenous glucose tolerance test had identical results; there was statistically significant agreement between the two examinations.
  
  
  CONCLUSIONS
  To assess the effectiveness of diazoxide treatment (Proglicem) on hypoglycaemia in nesidiomas it is sufficient to evaluate the IRI/G coefficient (on fasting) before and during diazoxide treatment (Proglicem, Schering Corp.).
authors.affiliation: III. interní klinika 1. LF UK a FN 2 s FP, Praha.
authors.forename: G
authors.initials: G
authors.lastname: Sindelka
authors.forename: J
authors.initials: J
authors.lastname: Skrha
authors.forename: S
authors.initials: S
authors.lastname: Svacina
authors.forename: V
authors.initials: V
authors.lastname: Justová
authors.forename: D
authors.initials: D
authors.lastname: Wichterle
mesh_terms: D000328:Adult; D000368:Aged; D003981:Diazoxide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000188:drug therapy* / Q000209:etiology; D007340:Insulinoma / Q000150:complications; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications
chemical_list: D003981:Diazoxide
vernacular_title: Efekt Proglicemu u nemocných se syndromem organického hyperinzulinismu.