Linear accelerator-based stereotactic radiosurgery for acoustic schwannomas.
OBJECTIVE
Stereotactic radiosurgery (SRS) is currently being investigated for treatment of acoustic schwannomas in patients who are not good surgical candidates. The vast majority of the available data is based on gamma knife-treated patients. We present the largest series of patients treated with linear accelerator-based SRS.


METHODS
Thirty-two patients with acoustic schwannomas were treated with SRS between July 1988 and February 1993; follow-up ranged from 4-59 months. Age ranged from 34-88 years (mean, 62 years). The primary presenting symptom was hearing loss in 30 patients and dementia in two patients. Indications for SRS were age > 65 years (17 patients); recurrence after surgery (13 patients); and medical infirmity (two patients). Dose to the periphery of the lesion ranged from 10-22.5 Gy (mean, 15.5 Gy) specified at the 68-90% isodose line (mean, 80%). Collimator size ranged from 12-35 mm (mean, 23 mm), indicating that the sizes of the tumors were significantly larger than those reported in most gamma knife series.


RESULTS
Follow-up magnetic resonance imaging (MRI) and/or computed tomography (CT) scans revealed the following at 1 year: tumor regression, 12 patients (63%); and no change, seven patients (37%). At 2 years, 11 tumors (73%) were smaller and four tumors (27%) were unchanged. At 3 years, seven patients (78%) had experienced tumor regression and two (22%) had no change. No patient experienced tumor progression after SRS. Seven patients (22%) suffered one or more treatment complications: new onset of 5th and/or 7th cranial nerve deficit (six patients), ataxia (two patients), and/or hydrocephalus necessitating VP shunt (two patients).


CONCLUSIONS
Linear accelerator-based SRS provides excellent short-term local control and a relatively low incidence of complications for acoustic schwannomas. Our data compare favorably with results obtained with gamma knife-based SRS. Additional follow-up will be necessary to evaluate the long-term results of treatment.
Mendenhall
W M
WM
Department of Radiation Oncology, University of Florida College of Medicine.
Friedman
W A
WA
Bova
F J
FJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects