[Experimental study on prevention of the colorectal cancer by China medical stone and the organgermanium compound].
To compare the effect of cancer prevention of China medical stone (CMS) and Ge-132, rats were subcutaneously injected with dimethylhydrazine for 15 weeks and orally administered with 10% china medical stone soak and Ge-132 for 27 weeks. Colorectal cancer incidence in CMS was found significantly lower than in Ge-132 and controls (P < 0.05-0.01). In Ge-132 only the mean cancer foci and the mean cancer volumes/rat were found significantly less than controls (P < 0.01). It was shown by endoscopy that a precancerous lesion of the bowel resulted from carcinogen was more mild in CMS and Ge-132 than in controls. Serum gamma-interferon titer and NK activity of spleen cells were significantly elevated in CMS and Ge-132. Researches explained that the effect of cancer prevention of CMS was better than that of Ge-132.
Song
W S
WS
Pearl River Hospital, First Medical University of PLA, Guangzhou.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D004127:Dimethylhydrazines; D005260:Female; D005857:Germanium / Q000627:therapeutic use*; D008419:Materia Medica / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011422:Propionates; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D004127:Dimethylhydrazines; D008419:Materia Medica; D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium