[Lipoxygenase inhibitors. 3. Synthesis of tetrahydrobenzazepinone phenylhydrazones].
Tetrahydro-2H-benz[b]azepin-2-ones as starting substances are synthesized by Beckmann rearrangement of Schmidt reaction. The tetrahydrobenzazepinones are transformed into the thiones, thiolactim ethers and phenylhydrazones. The compounds are tested as inhibitors of soja lipoxygenase.
Büge
A
A
Institut für Pharmazeutische Chemie, Martin-Luther-Universität Halle-Wittenberg.
Locke
C
C
Köhler
T
T
Nuhn
P
P
D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010659:Phenylhydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013025:Glycine max / Q000201:enzymology
D001381:Azepines; D016859:Lipoxygenase Inhibitors; D010659:Phenylhydrazines
Lipoxygenase-Inhibitoren, 3. Mitt.: Synthese von Tetrahydrobenzazepinon-phenylhydrazonen.