title: [The etiological aspects of the sick sinus syndrome].
abstract: A clinico-genetic study of sick sinus syndrome in Krasnoyarsk population established its prevalence as 0.296%. The disease affected females more frequently than males. The highest morbidity was registered at the age 60-69. Genetic evaluation demonstrated high hereditary predisposition to the syndrome as it developed in 60 out of 309 (19.4%) relatives of the patients, the inheritance being autosomal dominant and in part sex-limited. Females predominated among the disease-affected relatives and among those whose relatives had the syndrome. The syndrome is also age-related. The authors discuss the role of ischemic heart disease in the origin of sick sinus syndrome.
authors.forename: V A
authors.initials: VA
authors.lastname: Shul'man
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Nikulina
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: V B
authors.initials: VB
authors.lastname: Saliukov
authors.forename: G V
authors.initials: GV
authors.lastname: Matiushin
authors.forename: V V
authors.initials: VV
authors.lastname: Kusaev
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution; D012800:Siberia / Q000453:epidemiology; D012804:Sick Sinus Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D014505:Urban Population / Q000706:statistics & numerical data
vernacular_title: Nekotorye étiologicheskie aspekty sindroma slabosti sinusovogo uzla.