[The immunity indices of animals immunized with the inactivated Marburg virus after infection with homologous virus].
The data on changes in the parameters of specific and nonspecific immunity after challenge of the immunized animals with Marburg virus are presented. Mediators of the immune response: tumor necrosis factor, interferon, were shown to play different roles in the development of the disease and "protection" of animals. The survival rate of the immunized animals after the challenge with Marburg virus was determined by the intensity and level of the immune response after challenge rather than by the levels of postvaccination immunity at the time of the challenge.
Ignat'ev
G M
GM
Strel'tsova
M A
MA
Agafonov
A P
AP
Zhukova
N A
NA
Kashentseva
E A
EA
Vorob'eva
M S
MS
D000818:Animals; D000917:Antibody Formation; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007114:Immunization; D008379:Marburg Virus Disease / Q000276:immunology* / Q000473:pathology; D029024:Marburgvirus / Q000276:immunology*; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D015164:Vaccines, Inactivated; D014765:Viral Vaccines
Nekotorye pokazateli immuniteta u zhivotnykh, immunizirovannykh virusom Marburg, posle zarazheniia gomologichnym virusom.