title: [Invasive bronchopulmonary aspergillosis treated with itraconazole in a patient with acute leukemia].
abstract: A case of invasive broncopulmonar aspergillosis caused by Aspergillus terreus successfully treated with itraconazole is reported in a patient undergoing autologous bone marrow transplantation for acute lymphoblastic leukaemia. Although the patient was on prophylaxis with fluconazole and she did not respond to amphotericin B, there was an excellent response to itraconazole which allowed the transplant without any Aspergillus infection during both the transplant and the post-transplant periods. Due to its oral administration, good tolerance and low toxicity, itraconazole is a promising drug for the treatment of invasive broncopulmonar aspergillosis.
authors.affiliation: Sección Clínica-Citología, Hospital de Cruces, Baracaldo, Vizcaya.
authors.forename: J C
authors.initials: JC
authors.lastname: Sarcía-Ruiz
authors.forename: C
authors.initials: C
authors.lastname: Alvarez
authors.forename: F
authors.initials: F
authors.lastname: Floristán
authors.forename: I
authors.initials: I
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Hernández
authors.forename: A
authors.initials: A
authors.lastname: Alvarez Blanco
authors.forename: J
authors.initials: J
authors.lastname: Ponton
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced / Q000150:complications; D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D016026:Bone Marrow Transplantation; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D017964:Itraconazole / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D012074:Remission Induction
chemical_list: D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole
vernacular_title: Aspergilosis broncopulmonar invasiva tratada con itraconazol en una paciente con leucemia aguda.