Effects of desipramine on autonomic control of the heart.
OBJECTIVE
To assess the effects of desipramine (DMI) on autonomic control of the heart.


METHODS
Blood pressure, RR interval (the time between successive heart beats), and RR interval variability, a noninvasive measure of autonomic control of the heart, were assessed in 13 subjects younger than 30 years old.


RESULTS
DMI treatment was associated with an increase in blood pressure, a decrease in RR interval, and a decline in low and high frequency RR interval variability.


CONCLUSIONS
These preliminary data suggest that, in young people, DMI treatment produces a substantial decrease in parasympathetic input to the heart and an increase in the ratio of sympathetic to parasympathetic input, changes that in certain circumstances have been associated with an increased risk of arrhythmia. In exploring the cardiac effects of the tricyclic antidepressants (TCAs) in young people, the impact of TCAs on autonomic input to the heart should be examined.
Walsh
B T
BT
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY.
Giardina
E G
EG
Sloan
R P
RP
Greenhill
L
L
Goldfein
J
J
D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002032:Bulimia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D003891:Desipramine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000503:physiopathology
D003891:Desipramine