The induction of ovulation with pulsatile gonadotrophin-releasing hormone (GnRH) administration in hyperandrogenic women after down-regulation with buserelin or suppression with an oral contraceptive.
The hypothalamic-pituitary axis of 22 hyperandrogenic infertile women had suppression with either the gonadotrophin-releasing hormone (GnRH)-analogue buserelin (n = 12) or with an oestrogen-gestagen compound (Diane; n = 12). This was followed by pulsatile GnRH application for inducing ovulation (Zyklomat). In terms of ovulation and pregnancy rates the buserelin pre-treatment was more effective than the steroid pre-treatment, especially in hyperandrogenic non-polycystic ovaries (PCO).
Gerhard
I
I
Department of Gynaecological Endocrinology, Women's Hospital, University of Heidelberg, Germany.
Matthes
J
J
Runnebaum
B
B
D000328:Adult; D002064:Buserelin / Q000627:therapeutic use*; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D017373:Cyproterone Acetate / Q000627:therapeutic use*; D015536:Down-Regulation / Q000187:drug effects; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications*; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007260:Infusion Pumps; D010062:Ovulation Induction / Q000379:methods*
D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D007987:Gonadotropin-Releasing Hormone; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C032640:Cyproterone acetate, ethinyl estradiol drug combination; D002064:Buserelin