title: Impact of increasing calcium in the diet on nutrient consumption, plasma lipids, and lipoproteins in humans.
abstract: This study examined the feasibility of increasing food-derived calcium to 1500 mg/d and the impact of this change on plasma lipids and nutrient consumption in hypertensive (n = 130) and normotensive (n = 196) participants. Three interventions were applied in a randomized, parallel, placebo-controlled fashion: 1) counseling to increase dietary calcium through food consumption to 1500 mg/d (n = 106), 2) a 1000-mg/d calcium supplement (n = 109), or 3) placebo (n = 111). Plasma lipids were measured before and after 12 wk of intervention whereas nutrient intake was monitored throughout the study. At baseline, hypertensive patients reported lower intakes of carbohydrates, calcium, magnesium, phosphorus, potassium, iron, vitamin D, thiamin, and riboflavin (all P < 0.05). They also had lower HDL (P = 0.014) and higher LDL (P < 0.05) compared with normotensive subjects. During intervention, calcium, magnesium, phosphorus, potassium, thiamin, riboflavin, and vitamins C and D increased (P < 0.01) in the group receiving food calcium but not in the placebo or supplement groups. No changes occurred in plasma lipids or lipoproteins after 12 wk of intervention.
authors.affiliation: Department of Medicine, Oregon Health Sciences University, Portland 97201.
authors.forename: N
authors.initials: N
authors.lastname: Karanja
authors.forename: C D
authors.initials: CD
authors.lastname: Morris
authors.forename: P
authors.initials: P
authors.lastname: Rufolo
authors.forename: G
authors.initials: G
authors.lastname: Snyder
authors.forename: D R
authors.initials: DR
authors.lastname: Illingworth
authors.forename: D A
authors.initials: DA
authors.lastname: McCarron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D004435:Eating; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena
chemical_list: D002136:Calcium, Dietary; D008055:Lipids; D008074:Lipoproteins