Studies on mechanism of action of glycyrrhizin against hepatitis A virus replication in vitro.
Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [3H]uridine-labelled virions to cells. GL inhibited HAV penetration of the plasma membrane as measured by the amount of infective virus no longer neutralizable by specific antibody over time.
Crance
J M
JM
Unité de Biologie Moléculaire, Centre de Recherches du Service de Santé des Armées, La Tronche, France.
Lévêque
F
F
Biziagos
E
E
van Cuyck-Gandré
H
H
Jouan
A
A
Deloince
R
R
D000956:Antigens, Viral / Q000187:drug effects / Q000378:metabolism; D000998:Antiviral Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D035921:Hepatitis A Antigens; D006507:Hepatovirus / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects*
D000956:Antigens, Viral; D000998:Antiviral Agents; D035921:Hepatitis A Antigens; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid