title: [Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases].
abstract: Prazosin is a selective peripheral alpha 1-adrenoceptor antagonist used in the treatment of hypertension and heart failure. This drug has the disadvantage of relatively short terminal half-life (of the order of 2 to 3 hours); its wide use has been limited by the number of daily administrations. Recently, a new formulation of prazosin has been commercialized i.e., prazosin-gastrointestinal therapeutic system (P-GITS) given once daily in doses of either 2.5 or 5.0 mg (i.e., Alpress). The potential suitability of this controlled-release system as treatment of hypertension during pregnancy seems important. However, the possible transplacental passage of PRZ was unknown. We aimed to study this phenomenon in three pregnant women given a once daily 5 mg dose of P-GITS during the third trimester of pregnancy. There is a slight transplancental passage of prazosin i.e., of the order of 10 to 20% of the maternal concentration level determined at the same time. Concerning neonatal outcome, no problems were noted and the babies left the hospital in good health. Prazosin-GITS offers a new approach to control and improve the outcome of hypertensive therapy during pregnancy.
authors.affiliation: Service de Pharmacie Clinique, Hôpital Antoine-Béclère, Clamart.
authors.forename: P
authors.initials: P
authors.lastname: Bourget
authors.forename: H
authors.initials: H
authors.lastname: Fernandez
authors.forename: F
authors.initials: F
authors.lastname: Ribou
authors.forename: D
authors.initials: D
authors.lastname: Edouard
authors.forename: R
authors.initials: R
authors.lastname: Frydman
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D016903:Drug Monitoring; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008431:Maternal-Fetal Exchange; D011224:Prazosin / Q000097:blood / Q000493:pharmacokinetics* / Q000600:supply & distribution / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third
chemical_list: D003692:Delayed-Action Preparations; D011224:Prazosin
vernacular_title: Faible passage transplacentaire de la prazosine (Alpress) au cours du troisième trimestre de la grossesse. A propos de trois cas.