Developmental toxicity in hamsters of an aqueous extract of Fusarium moniliforme culture material containing known quantities of fumonisin B1.
The purpose of this study was to investigate potential detrimental effects of fumonisin B1 on the developing hamster. In experiments 1 and 2, timed-bred hamsters were dosed with 0.0 to 12.0 mg fumonisin B1/kg from day 8 to day 10 or day 12 of gestation. Clinical signs of material toxicity were not observed. Pregnant animals had reduced weight gains and lower total bilirubin levels than nonpregnant females. Hamsters were euthanized on day 15 of gestation. Histologic evaluation revealed autolytic placental changes expected in terminal gestation, as well as more advanced placental necrosis in association with fetal resorptions. Mean fetal weights and crown-rump lengths of living term fetuses on a per-litter basis did not differ between untreated controls and treated animals given 6.0 mg fumonisin B1/kg or less. However, at higher doses of fumonisin B1, there was an increased incidence of prenatal losses (deaths and resorptions). A greater percentage of litters had 1 or more fetuses affected, and a greater percentage of total fetuses were lost/litter as the fumonisin dosage increased. At 12.0 mg/kg, all litters were affected and 100% of the fetuses were dead and resorbing. Fumonisin B1 appears a developmental toxicant in hamsters. Toxicity is manifest by increased numbers of prenatal deaths and resorptions at doses that do not induce clinicopathologic evidence of maternal toxicity.
Floss
J L
JL
Department of Veterinary Medicine and Surgery, University of Missouri, Columbia 65211.
Casteel
S W
SW
Johnson
G C
GC
Rottinghaus
G E
GE
Krause
G F
GF
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D006224:Cricetinae; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000473:pathology; D005516:Food Microbiology; D037341:Fumonisins; D005670:Fusarium / Q000378:metabolism*; D005865:Gestational Age; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008647:Mesocricetus; D009183:Mycotoxins / Q000633:toxicity*; D011247:Pregnancy; D015430:Weight Gain / Q000187:drug effects; D003313:Zea mays / Q000737:chemistry
D002274:Carcinogens, Environmental; D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1