title: The effect of titanium tetrafluoride (TiF4) application around orthodontic brackets.
abstract: In the present in vivo study, the cariostatic potential of a titanium tetrafluoride (TiF4) solution applied topically around orthodontic brackets was investigated with quantitative microradiography. Also characteristics of the TiF4-treated enamel surface were examined with scanning electron microscopy (SEM). Ten pairs of premolars to be extracted for orthodontic treatment were used in the first part of this study. Brackets were bonded on all teeth with an orthodontic adhesive, and 10 randomly selected premolars served as controls, whereas a similar number were treated with 1% TiF4 around brackets for 60 seconds. After 4 weeks with no topical fluoride supplementation, all teeth were extracted and stored for analysis. Results indicated the 1% TIF4 solution reduced lesion depths and total mineral loss, at the bracket periphery, significantly during the 4-week period. The presence of a surface coating was demonstrated by SEM micrographs. It was concluded that TiF4 may provide a high level performance as a prophylactic agent for orthodontic purposes.
authors.affiliation: Department of Orthodontics, Faculty of Dentistry, University of Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Büyükyilmaz
authors.forename: V
authors.initials: V
authors.lastname: Tangugsorn
authors.forename: B
authors.initials: B
authors.lastname: Ogaard
authors.forename: J
authors.initials: J
authors.lastname: Arends
authors.forename: J
authors.initials: J
authors.lastname: Ruben
authors.forename: G
authors.initials: G
authors.lastname: Rølla
mesh_terms: D002648:Child; D003743:Dental Enamel / Q000187:drug effects / Q000648:ultrastructure; D005459:Fluorides / Q000494:pharmacology / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008852:Microradiography; D008855:Microscopy, Electron, Scanning; D016910:Orthodontic Brackets / Q000009:adverse effects; D014025:Titanium / Q000494:pharmacology / Q000627:therapeutic use*; D017001:Tooth Demineralization / Q000209:etiology / Q000517:prevention & control*
chemical_list: D005460:Fluorides, Topical; D014025:Titanium; D005459:Fluorides; C032240:titanium tetrafluoride