Oxygen uptake and carbon dioxide elimination during controlled hypotension induced by prostaglandin E1 or nitroglycerin.
To compare the effects of prostaglandin E1 (PGE1) with those of nitroglycerin (NTG) on whole body metabolism (oxygen uptake (VO2) and carbon dioxide elimination (VCO2) during induced hypotension, we have studied 16 patients undergoing elective surgery (radical mastectomy or tympanoplasty). The patients were allocated randomly in a non-blinded manner to two groups. Baseline characteristics were similar in the two groups. Arterial pressure was controlled at about 70% of the baseline value using PGE1 or NTG. VO2, VCO2, gas exchange ratio (RQ) and deadspace ventilation ratio (VD/VT) were measured continuously with mass spectrometry. The values for all variables were measured for 10 min at five times (1 = start of surgery (baseline value); 2 = start of drug infusion; 3 = 60 min after start of drug infusion; 4 = drug infusion stopped; 5 = surgery finished). VO2, VCO2, RQ and VD/VT values were relatively constant in both groups during surgery. The balance between oxygen supply and oxygen demand was maintained during induced hypotension with PGE1 or NTG.
Shiraishi
Y
Y
Department of Anaesthesiology, Shizuoka General Hospital, Japan.
Mochizuki
T
T
Ikeda
K
K
D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism*; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology*; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D012126:Respiratory Dead Space; D013997:Time Factors
D002245:Carbon Dioxide; D000527:Alprostadil; D005996:Nitroglycerin