8-Hydroxymanzamine A, a beta-carboline alkaloid from a sponge, Pachypellina sp.
The previously described manzamine A [1] and the new 8-hydroxymanzamine A [2] were isolated from an undescribed sponge, Pachypellina sp. Both compounds exhibit moderate antitumor and anti-HSV-II activity.
Ichiba
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Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822.
Corgiat
J M
JM
Scheuer
P J
PJ
Kelly-Borges
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002243:Carbolines / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002243:Carbolines; C086783:8-hydroxymanzamine A