title: Donor thyroid function does not affect outcome in orthotopic liver transplantation.
abstract: Brainstem death is associated with endocrine and metabolic alterations that can result in donor hemodynamic instability. It has been suggested that these changes can be reversed through hormonal manipulation of the donor. We measured thyroid hormone levels (free triiodothyronine [fT3], free tetraiodothyronine [fT4], reverse triiodothyronine) and thyroid-stimulating hormone (TSH) in 50 consecutive adult brain dead multiorgan donors. Recipient graft function was assessed using peak and day 5 aspartate aminotransferase, peak serum bilirubin, and minimum prothrombin time during the first week after OLT. Free T3 was low in 32/50 donors and was associated with a low fT4 in 24 cases. TSH was normal in 35 donors and we found no correlation between TSH levels and fT3 or fT4. Reverse triiodothyronine was normal or high in 96% of donors. Patient and graft survival were 96% for both the low and high fT3 groups. These data suggest that euthyroid sick syndrome is the most likely cause for the endocrine and metabolic alterations seen in brainstem-dead donors. This does not appear to influence liver recipient or graft survival.
authors.affiliation: Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.
authors.forename: K
authors.initials: K
authors.lastname: Karayalçin
authors.forename: J P
authors.initials: JP
authors.lastname: Umaña
authors.forename: J D
authors.initials: JD
authors.lastname: Harrison
authors.forename: J A
authors.initials: JA
authors.lastname: Buckels
authors.forename: P
authors.initials: P
authors.lastname: McMaster
authors.forename: A D
authors.initials: AD
authors.lastname: Mayer
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000503:physiopathology; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000032:analysis; D014019:Tissue Donors
chemical_list: D013963:Thyroid Hormones