[Sequential observation on the influence of artificial wind-cold environment to immunologic function of mononuclear phagocytic system in mice].
According to TCM theory of Six Evils, the Wind-Cold is one of the pathogen. In order to find the mechanism of Wind-Cold in causing disease, the effect of subacute Wind-Cold stimulation on the phagocyte immunization in mice was observed. Results showed that through exposing in the Wind-Cold environment, the reticuloendothelial system (RES) clearance function and the hydrogen-peroxide releasing of peritoneal macrophage were suppressed. Sequential observation showed that the peak of immunosuppression occurred on the 3rd day after stimulation and began to normalize at 5th day. These results suggested that Wind-Cold stimulation could inhibit temporary phagocytosis of macrophage and bacteriocidal effect. Action of immunosuppression was believed to be produced by the increase of stress hormone after stimulation. Results also suggested that the pathogenic action of Wind-Cold on disease is somewhat related with the suppression of nonspecific cellular immunity.
Chen
X
X
Shenzhen Red Cross Hospital, Clinical institute of integrated TCM and WM.
Ou
Y X
YX
Chen
J W
JW
D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D004777:Environment; D007108:Immune Tolerance; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000276:immunology; D010587:Phagocytosis; D014919:Wind