title: Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome.
abstract: Magnolol and honokiol, biphenyl compounds, were isolated as anti-emetic principles from the methanolic extract of Magnolia obovata bark. [6]-, [8]-, and [10]-shogaols and [6]-, [8]-, and [10]-gingerols were isolated from the methanolic extract of Zingiber officinale rhizome as anti-emetic principles. Some phenyl-propanoids with allyl side-chains were found to show the same activity. They inhibited the emetic action induced by the oral administration of copper sulfate pentahydrate to leopard and ranid frogs.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Koyama
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000302:isolation & purification / Q000494:pharmacology*; D001001:Anura; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology; D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D017705:Lignans; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000932:Antiemetics; D001713:Biphenyl Compounds; D002396:Catechols; D005233:Fatty Alcohols; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C040115:shogaol; C007845:gingerol