title: [Changes in therapy of severe acute pancreatitis].
abstract: Report about the treatment of necrotizing pancreatitis in the years 1988 until 1991. A rigorous conservative therapy was preferred, so that only 8.6% of the 140 patients underwent surgery. In 11 cases a continuous venous-venous hemofiltration (CVVH) was applied to patients with most serious clinical course and multi-system failure. The overall lethality rate of all treated patients was 7.9%. The present results show, that, eliminating mediators by hemofiltration, system failure in connection with sterile necrosis can be treated with a good success rate. Therefore toxic organ failure should no longer be regarded as an imperative indication for operation. We recommend strict intensive care including CVVH and antibiotical prophylaxis for treatment of sterile necrosis, while surgical therapy should only be applied to patients with bacterial contamination of pancreatic necrosis.
authors.affiliation: Chirurgisches Zentrum, Städtischen Klinikums, Nürnberg.
authors.forename: C
authors.initials: C
authors.lastname: Gebhardt
authors.forename: H
authors.initials: H
authors.lastname: Bödeker
authors.forename: L
authors.initials: L
authors.lastname: Blinzler
authors.forename: D
authors.initials: D
authors.lastname: Kraus
authors.forename: G
authors.initials: G
authors.lastname: Hergdt
mesh_terms: D000208:Acute Disease; D000368:Aged; D002423:Cause of Death; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods*; D005260:Female; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000145:classification / Q000401:mortality / Q000628:therapy; D009336:Necrosis; D010180:Pancreatectomy / Q000379:methods*; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000145:classification / Q000401:mortality / Q000628:therapy*; D010533:Peritoneal Lavage; D015996:Survival Rate
vernacular_title: Wandel in der Therapie der schweren akuten Pankreatitis.