New translocation involving homologous chromosome 3 in acute myelogenous leukemia (M2)
An apparent balanced translocation involving the long arms of homologous chromosomes is described for the first time in a patient with acute myelogenous leukemia (AML) (M2), i.e., 46,XY,t(3;3) (q21;q26). After reviewing the literature, it was noted that a breakpoint involving band 3q26 is a frequent anomaly in other translocations. Thus, we are tempted to hypothesize that 3q26 band may also play an important role in the pathogenesis of AML (M2).
Verma
R S
RS
Division of Genetics, Long Island College Hospital--SUNY Health Science, Brooklyn 11201.
da Costa
M
M
Gogineni
S K
SK
Palermo
G
G
D000328:Adult; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic