title: Splenic lymphoma with villous lymphocytes. Report of first 2 cases from the Middle East.
abstract: Two cases of splenic lymphoma with villous lymphocytes (SLVL) were diagnosed on the basis of marked splenomegaly, circulating villous lymphocytes, serum IgM monoclonal paraprotein and bone marrow infiltration. Immunological studies confirmed the B cell phenotype (CD19+, CD20+, CD22+ and CD5- and CD25-). Ultrastructural studies revealed characteristic uneven villi with polar predisposition. Interferon-alpha therapy in 1 patient did not result in any clinical or hematological improvement. This is the first report of SLVL from the Middle East.
authors.affiliation: Department of Haematology, Kuwait Cancer Control Centre.
authors.forename: S
authors.initials: S
authors.lastname: al-Bahar
authors.forename: R
authors.initials: R
authors.lastname: Pandita
authors.forename: B N
authors.initials: BN
authors.lastname: Dhabhar
authors.forename: E
authors.initials: E
authors.lastname: al-Bahar
mesh_terms: D001402:B-Lymphocytes / Q000648:ultrastructure; D001706:Biopsy; D001853:Bone Marrow / Q000648:ultrastructure; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007730:Kuwait; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000628:therapy / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000628:therapy / Q000648:ultrastructure; D013163:Splenomegaly / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
chemical_list: D016898:Interferon-alpha