[Correlation between adhesive factors of primary hemostasis and liver fibrogenesis in alcoholic live cirrhosis].
Colchicine administration is able to reduce collagen production and the fibrogenetic process in alcoholic liver diseases in the same time. The decrease of the serum lipid peroxidation capacity along with type III procollagen propeptide level was associated with the simultaneous reduction of plasmatic von Willebrand factor, fibronectin and beta-thromboglobulin levels. This observation suggest a connection between the regulation of primary haemostasis and liver fibrogenesis.
Udvardy
M
M
Debreceni Orvostudományi Egyetem II. Belgyógyászati Klinika.
Hársfalvi
J
J
Pósán
E
E
Káplár
M
M
Katona
E
E
Rák
K
K
D003078:Colchicine / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis; D004341:Drug Evaluation; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D006814:Hungary; D015227:Lipid Peroxidation; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000188:drug therapy; D008297:Male; D011347:Procollagen / Q000096:biosynthesis
D005353:Fibronectins; D011347:Procollagen; D003094:Collagen; D003078:Colchicine
A primer haemostasis adhezív tényezöi és a máj fibrogenesis kapcsolata alkoholos májcirrhosisban.