title: Malaria transmission-blocking activity in experimental infections of Anopheles gambiae from naturally infected Plasmodium falciparum gametocyte carriers.
abstract: Experimental infections of anopheline mosquitoes were carried out with Plasmodium falciparum gametocytes from 65 naturally infected patients in Cameroon. A comparison was made between infections with blood containing autologous plasma and blood in which the plasma was replaced with plasma from a donor without previous malaria exposure. A lower infection rate was observed in 50 of 65 autologous plasma samples. Transmission was significantly blocked in 3 infections. This indicates that, in a population living in an area endemic for malaria, blood plasma factor(s) can reduce the transmission capacity of gametocyte carriers to mosquitoes.
authors.affiliation: University of Wageningen, Nijmegen, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Mulder
authors.forename: T
authors.initials: T
authors.lastname: Tchuinkam
authors.forename: K
authors.initials: K
authors.lastname: Dechering
authors.forename: J P
authors.initials: JP
authors.lastname: Verhave
authors.forename: P
authors.initials: P
authors.lastname: Carnevale
authors.forename: J H
authors.initials: JH
authors.lastname: Meuwissen
authors.forename: V
authors.initials: V
authors.lastname: Robert
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D002353:Carrier State / Q000097:blood* / Q000276:immunology; D002648:Child; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000097:blood / Q000276:immunology / Q000635:transmission*; D010949:Plasma / Q000276:immunology