Identification of the iroA gene product of Neisseria meningitidis as a lactoferrin receptor.
The iroA gene product is an iron limitation-inducible outer membrane protein of Neisseria meningitidis. A spontaneous mutant lacking the gene was unable to bind lactoferrin. Furthermore, Escherichia coli strains expressing the IroA protein were capable of binding lactoferrin. Apparently, the IroA protein functions as a lactoferrin receptor.
Pettersson
A
A
Department of Molecular Cell Biology, Utrecht University, The Netherlands.
Maas
A
A
Tommassen
J
J
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics / Q000502:physiology*; D007781:Lactoferrin / Q000378:metabolism; D009345:Neisseria meningitidis / Q000235:genetics* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D014168:Transferrin / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D011956:Receptors, Cell Surface; D014168:Transferrin; C083821:iroA protein, bacteria; C038340:lactoferrin receptors; D007781:Lactoferrin