A comparison study of IFN-gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis.
Adenosine deaminase in pleural fluid (pADA), CA125 in serum (sCA125), and IFN-gamma in pleural fluid (pIFN-gamma) were measured in patients with pleurisy of various causes to evaluate their diagnostic utility in tuberculous pleuritis (TBP). We studied 39 pleural fluid samples, including 11 TBP and 28 non-TBP. With both pADA and sCA125, although the median values were much higher in TBP than in non-TBP groups, there was considerable overlap between the two groups. The sensitivity, specificity, and diagnostic efficiency were 81.8%, 89.3%, and 87.2%, respectively, when pADA values of more than 45 U ml-1 were considered, and they were 100%, 75.0%, and 84.2%, respectively, when sCA125 values of more than 35 U ml-1 were considered. In contrast, pIFN-gamma values were significantly higher in TBP patients (5.8 +/- 3.0 IU ml-1; mean +/- S.D.) than those in non-TBP patients (< 0.3 IU ml-1), leading to both a sensitivity and a specificity of 100%.
Aoki
Y
Y
Department of Internal Medicine, Saga Medical School, Japan.
Katoh
O
O
Nakanishi
Y
Y
Kuroki
S
S
Yamada
H
H
D000243:Adenosine Deaminase / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D008297:Male; D010996:Pleural Effusion / Q000276:immunology; D014396:Tuberculosis, Pleural / Q000175:diagnosis* / Q000276:immunology
D015295:Antigens, Tumor-Associated, Carbohydrate; D015415:Biomarkers; D007371:Interferon-gamma; D000243:Adenosine Deaminase