Study of the effects of treatment with theophylline on the cognitive process and behaviour of children with bronchial asthma.
The effects of theophylline (T) on cognitive and emotional aspects were evaluated in nine children with mild bronchial asthma (7-14 years). The study was double blind crossover against placebo (P) for a period of 30 days for each. The children admitted to the study had an average IQ (80-101) and were able to perform pulmonary function studies (PFS). On days 0, 30 and 60 patients were evaluated by psychological tests (Wisc, Bender, Complex Figure A. Rey and Miss Goodenough/Machouver). PPS an T serum levels were performed on days 15 and 45. During the T period all patients had T serum levels greater than 5 mcg/ml (5 to 22). The final evaluation showed no changes in the psychological tests. Behaviour alterations were not reported by the parents. In conclusion, in this group of patients there was no influence of T on the asthmatic children's behavior. These results are in agreement with the recent data published by Schlieper et al. (J. Pediatr. 118: 449-455, 1991).
Gil
C A
CA
Department of Pediatrics, Escola Paulista de Medicina, São Paulo, Brasil.
Silveira
M L
ML
Soares
F J
FJ
Solé
D
D
Naspitz
C
C
D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D011581:Psychological Tests; D013806:Theophylline / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
D013806:Theophylline