title: [Monoclonal antibodies in blood group serology. Part 1: Technique of production, ABO and Lewis system].
abstract: OBJECTIVE
  The introduction of monoclonal antibodies in routine blood group typing has also given rise to new findings. This paper was designed to demonstrate and clarify modifications relevant in practice.
  
  
  METHODS
  Our own experience in the production and application of monoclonal antibodies as well as the relevant literature are taken into consideration.
  
  
  RESULTS
  The development and production of murine and human monoclonal antibodies is described especially regarding the selection and the safety of clones. An update of the availability and use of monoclonal antibodies in respect to the different blood group systems is given, with special reference to new findings like the A1(B) and B(A) phenomena.
  
  
  CONCLUSIONS
  The application of monoclonal antibodies in blood group serology has improved the detection of weak variants and the availability of these reagents in general. Further improvements in this technology will make monoclonal antibodies also available for other blood group systems.
authors.affiliation: Biotest AG, Forschungsabteilung, Dreieich.
authors.forename: H H
authors.initials: HH
authors.lastname: Sonneborn
authors.forename: W
authors.initials: W
authors.lastname: Dahr
authors.forename: W
authors.initials: W
authors.lastname: Helmbold
authors.forename: D
authors.initials: D
authors.lastname: Kasulke
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000818:Animals; D000911:Antibodies, Monoclonal; D001788:Blood Grouping and Crossmatching / Q000379:methods*; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D010641:Phenotype
chemical_list: D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D007983:Lewis Blood Group Antigens
vernacular_title: Monoklonale Antikörper in der Blutgruppenserologie. Teil 1: Technik der Herstellung, AB0- und Lewis-System.