[Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases].
Prazosin is a selective peripheral alpha 1-adrenoceptor antagonist used in the treatment of hypertension and heart failure. This drug has the disadvantage of relatively short terminal half-life (of the order of 2 to 3 hours); its wide use has been limited by the number of daily administrations. Recently, a new formulation of prazosin has been commercialized i.e., prazosin-gastrointestinal therapeutic system (P-GITS) given once daily in doses of either 2.5 or 5.0 mg (i.e., Alpress). The potential suitability of this controlled-release system as treatment of hypertension during pregnancy seems important. However, the possible transplacental passage of PRZ was unknown. We aimed to study this phenomenon in three pregnant women given a once daily 5 mg dose of P-GITS during the third trimester of pregnancy. There is a slight transplancental passage of prazosin i.e., of the order of 10 to 20% of the maternal concentration level determined at the same time. Concerning neonatal outcome, no problems were noted and the babies left the hospital in good health. Prazosin-GITS offers a new approach to control and improve the outcome of hypertensive therapy during pregnancy.
Bourget
P
P
Service de Pharmacie Clinique, Hôpital Antoine-Béclère, Clamart.
Fernandez
H
H
Ribou
F
F
Edouard
D
D
Frydman
R
R
D000328:Adult; D003692:Delayed-Action Preparations; D016903:Drug Monitoring; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008431:Maternal-Fetal Exchange; D011224:Prazosin / Q000097:blood / Q000493:pharmacokinetics* / Q000600:supply & distribution / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third
D003692:Delayed-Action Preparations; D011224:Prazosin
Faible passage transplacentaire de la prazosine (Alpress) au cours du troisième trimestre de la grossesse. A propos de trois cas.