[Immunologic isolation of transplanted islets of Langerhans: microcapsules with defined molecular limits].
Immunoisolated transplantation of islets of Langerhans in barium alginate microcapsules is a promising therapeutic approach to cure diabetes. An improved membrane for the coating of barium alginate microcapsules has been developed. Chemically stable barium alginate microcapsules with a controlled molecular weight cutoff between 9400 and 40,500 D were obtained after coating of barium alginate capsules in Polybrene solutions. Microcapsules prepared by this new method were still freely permeable to low molecular weight substances.
Klöck
G
G
Lehrstuhl für Biotechnologie, Biozentrum der Universität Würzburg.
Siebers
U
U
Pfeffermann
A
A
Schmitt
J
J
Houben
R
R
Federlin
K
K
Zimmermann
U
U
D000464:Alginates; D001464:Barium; D006801:Humans; D066298:In Vitro Techniques; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008567:Membranes, Artificial; D008970:Molecular Weight; D010539:Permeability
D000464:Alginates; D008567:Membranes, Artificial; D001464:Barium
Immunisolation transplantierter Langerhansscher Inseln: Mikrokapseln mit definierter molekularer Ausschlussgrenze.