title: Ketoprofen for pain after hip and knee arthroplasty.
abstract: In a double-blind, randomized study, we have compared the effects of i.v. ketoprofen 200 mg followed by 12.5 mg h-1 over 13 h, with those of extradural morphine 4 mg in 32 patients after hip and knee arthroplasty. A visual analogue scale was used to score pain before analgesic administration (first complaint after operation), 1 h after and every 2 h subsequently. Pain reduction 1 h after the start of analgesia was mean 44% (SEM 17%) in the extradural morphine group and 54% (9%) in the ketoprofen group (ns). There were no significant differences between groups in pain scores, pain reduction and additional analgesia requirement (i.v. paracetamol). Naloxone 5 micrograms kg-1 h-1 was required for hypercapnia exceeding 6.0 kPa in three patients in the extradural morphine group (vs none in the ketoprofen group; ns). There were no differences between groups in side effects, except for urinary retention, which was more frequent in the extradural morphine group (P < 0.05). As there were few differences between i.v. ketoprofen and extradural morphine, we conclude that ketoprofen may be an efficient alternative to extradural morphine after hip and knee arthroplasty.
authors.affiliation: Clinique Saint Augustin, Nantes, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Hommeril
authors.forename: J M
authors.initials: JM
authors.lastname: Bernard
authors.forename: F
authors.initials: F
authors.lastname: Gouin
authors.forename: M
authors.initials: M
authors.lastname: Pinaud
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015360:Analgesia, Epidural; D004311:Double-Blind Method; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007275:Injections, Intravenous; D007660:Ketoprofen / Q000627:therapeutic use*; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D009020:Morphine; D007660:Ketoprofen