Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms.
The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.
Farkas
R H
RH
Department of Anatomy and Cell Biology, University of Illinois, College of Medicine at Chicago 60612.
Nakajima
S
S
Nakajima
Y
Y
D000818:Animals; D002478:Cells, Cultured; D002799:Cholinergic Fibers / Q000187:drug effects*; D004553:Electric Conductivity; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives; D007477:Ions; D008564:Membrane Potentials; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects; D009496:Neurotensin / Q000494:pharmacology*; D037342:Pertussis Toxin; D011188:Potassium / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D013377:Substantia Innominata / Q000166:cytology / Q000187:drug effects*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D007477:Ions; D010566:Virulence Factors, Bordetella; D009496:Neurotensin; D006160:Guanosine Triphosphate; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins; D011188:Potassium