Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease.
Localization of type 2 plasminogen activator inhibitor (PAI-2) was investigated immunohistochemically in postmortem brain tissue of control subjects and patients with Alzheimer's disease (AD). Both the mouse monoclonal and the goat polyclonal antibodies to PAI-2 stained microglia. Reactive microglia were stained more intensely than resting microglia. PAI-2 may regulate the plasminogen activators and plasmin system in lesions of AD. It is suggested that PAI-2 plays a role for cell migration and matrix breakdown as well as for aberrant neurite outgrowth in senile plaques where persistent microglial activation is observed.
Akiyama
H
H
Division of Neuropathology, Tokyo Institute of Psychiatry, Japan.
Ikeda
K
K
Kondo
H
H
Kato
M
M
McGeer
P L
PL
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000906:Antibodies / Q000032:analysis; D000911:Antibodies, Monoclonal; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007962:Leukocytes / Q000378:metabolism; D017628:Microglia / Q000378:metabolism*; D008875:Middle Aged; D017396:Plasminogen Activator Inhibitor 2 / Q000096:biosynthesis* / Q000276:immunology; D015854:Up-Regulation / Q000502:physiology
D000906:Antibodies; D000911:Antibodies, Monoclonal; D017396:Plasminogen Activator Inhibitor 2