Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue.
A marijuana compound, cannabinol [1], was converted to two metabolites using in vitro tissue of Pinellia ternata. The structures of the metabolites were determined to be cannabinol-O-beta-D-glucopyranoside [2] and 9'-hydroxycannabinol-O-beta-D-glucopyranoside [3] by 1H nmr and 13C nmr. From the time course experiments, 1 was absorbed rapidly in the tissues and glycosylated. Hydroxylation at the pentyl group occurred, and its metabolite was secreted in the medium.
Tanaka
H
H
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Morimoto
S
S
Shoyama
Y
Y
D001711:Biotransformation; D002187:Cannabinol / Q000737:chemistry / Q000493:pharmacokinetics*; D002188:Cannabis / Q000737:chemistry*; D002478:Cells, Cultured; D006027:Glycosides / Q000378:metabolism; D010944:Plants / Q000378:metabolism*
D006027:Glycosides; D002187:Cannabinol