Prevention of progression in non-diabetic chronic renal failure.
We have performed separate randomized prospective controlled studies on the effects of protein-restricted diet and angiotensin converting enzyme (ACE) inhibition on the rate of progression of non-diabetic renal failure. Renal function was assessed by creatinine clearance, reciprocal of plasma creatinine concentration and 51Cr-EDTA clearance. A protein-restricted diet (0.4 g per kg) resulted in a significantly lower rate of progression, as assessed by the slope of these parameters with time, when compared with a standard diet. ACE inhibition, when assessed by a mixed effect model, also significantly reduced the rate of progression. The many variables involved hinder trials of therapies directed against progression in non-diabetic renal failure.
Becker
G J
GJ
Department of Nephrology, Royal Melbourne Hospital, Victoria, Australia.
Whitworth
J A
JA
Ihle
B U
BU
Shahinfar
S
S
Kincaid-Smith
P S
PS
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D004044:Dietary Proteins / Q000008:administration & dosage; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D009395:Nephritis, Interstitial / Q000209:etiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D004044:Dietary Proteins