title: Rating impairment and disability in Parkinson's disease: evaluation of the Unified Parkinson's Disease Rating Scale.
abstract: Although the Unified Parkinson's Disease Rating Scale (UPDRS) is widely used to monitor disease progression and drug efficacy, no attempts have been made to evaluate its scientific and clinical quality. Poor clinical sensibility of items in the activities of daily living (ADL) section and redundancy of items in the motor examination (ME) section prompted us to determine if the number of items in these sections could be reduced to a smaller, equally sensitive set that would describe the data as reliably as did the original set of items. Therefore, we assessed 111 patients with idiopathic Parkinson's disease on the UPDRS and Hoehn and Yahr staging scales. Our results show that the ADL (13 items) and ME (14 items) sections can be reduced to 8 items each without loss of reliability or validity. Our report is preliminary and needs validation.
authors.affiliation: Department of Neurology, Academic Hospital, Leiden, Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: van Hilten
authors.forename: A D
authors.initials: AD
authors.lastname: van der Zwan
authors.forename: A H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000145:classification / Q000187:drug effects / Q000706:statistics & numerical data*; D010300:Parkinson Disease / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy; D015203:Reproducibility of Results
chemical_list: D000978:Antiparkinson Agents