Actions of acromelic acid on nervous system L-glutamate receptors.
Acromelic acid, a naturally occurring kainoid, isolated from the mushroom Clitocybe acromelalga, is a weak displacer of [3H]L-glutamate binding to cockroach (Periplaneta americana) nerve cord membranes. Acromelic acid (1 mM) displaces approximately 60% of specifically bound [3H]L-glutamate. When applied by bath perfusion to the cell body membrane of the cockroach fast coxal depressor motor neurone, acromelic acid generated slow, prolonged, dose-dependent depolarizations at concentrations of 0.3 microM and above. Thus acromelic acid is among the most potent of the excitatory amino acids tested to date on insect neurones.
Sattelle
D B
DB
Department of Zoology, University of Cambridge, United Kongdom.
Sepúlveda
M I
MI
Shinozaki
H
H
Ishida
M
M
D000818:Animals; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects; D010526:Periplaneta; D011869:Radioligand Assay; D017470:Receptors, Glutamate / Q000187:drug effects*
D017470:Receptors, Glutamate; C051743:acromelic acid A; D007608:Kainic Acid