Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands.
Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.
Constant
P
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Department III, Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS, Toulouse, France.
Davodeau
F
F
Peyrat
M A
MA
Poquet
Y
Y
Puzo
G
G
Bonneville
M
M
Fournié
J J
JJ
D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D002478:Cells, Cultured; D002852:Chromatography, Ion Exchange; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013942:Thymine Nucleotides / Q000032:analysis / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification
D000942:Antigens, Bacterial; D008024:Ligands; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013942:Thymine Nucleotides; C024157:thymidine 5'-triphosphate