Endometrial structure after superovulation: a prospective controlled study.
OBJECTIVE
To demonstrate the effect of superovulation using a GnRH agonist (GnRH-a) and hMG and hCG on endometrial structure.


METHODS
Prospective, case-controlled study.


METHODS
Tertiary referral assisted reproduction unit in an academic department.


METHODS
Eleven women undergoing GIFT or IVF, without ET.


METHODS
All women were treated with a long stimulation regimen using the depot GnRH-a Goserelin (ICI, Macclesfield, United Kingdom) and hMG and hCG.


METHODS
Comparison of endometrial biopsy specimens taken 4 days after ovulation in an unstimulated cycle with specimens taken 4 days after oocyte recovery, using standard dating criteria and morphometric analysis.


RESULTS
There was no difference in endometrial glandular development as assessed by either standard criteria or morphometric analysis.


CONCLUSIONS
Superovulation preceded by pituitary down regulation is not associated with abnormal endometrial glandular development, even though supraphysiological levels of E2 and P are induced.
Macrow
P J
PJ
Department of Obstetrics and Gynecology, University of Manchester, United Kingdom.
Li
T C
TC
Seif
M W
MW
Buckley
C H
CH
Elstein
M
M
D000328:Adult; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004717:Endometrium / Q000033:anatomy & histology* / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D013480:Superovulation
D006063:Chorionic Gonadotropin; D017273:Goserelin; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins