Effect of heparin on hemagglutinin of herpes simplex virus type 1.
Heparin inhibited the hemagglutinin activity of herpes simplex virus (HSV) type 1. The minimal inhibitory concentration of heparin required to inhibit 8 hemagglutination (HA) U of HSV ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the HA inhibitory factor of heparin. On the other hand, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by HSV. Virus-heparin complex formation was observed by sedimenting heparin with the virus particles.
Noda
M
M
Division of 2nd Microbiology, Hiroshima Prefectural Institute of Public Health and Environment Science, Japan.
Inaba
Y
Y
Seno
M
M
Kanamoto
Y
Y
Tokumoto
S
S
D000818:Animals; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006389:Hemagglutinins, Viral / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000276:immunology*; D051379:Mice
D006389:Hemagglutinins, Viral; D006493:Heparin