title: Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance.
abstract: Nineteen young male normolipidemic volunteers sequentially consumed three test meals consisting of cream only, sucrose only, or cream with sucrose. These oral fat-tolerance tests showed an amplification of the postprandial excursion of serum triglyceride and cholesterol concentrations when sucrose was included in a lipid-rich meal compared with both the cream-only meal and the sucrose-only meal. The triglyceride concentration increase occurred only in the late postprandial phase whereas the cholesterol concentration was increased for the entire 8 h studied. The increased triglyceride and cholesterol concentrations in the triglyceride-rich lipoprotein (TRL) fraction accounted for most of the increase. The clearance of an intravenous lipid emulsion was measured before and 2 and 4 h after a sucrose meal. The two postprandial clearance rates were 34% slower than the fasting value. These data indicate that sucrose-induced postprandial hypertriglyceridemia may be induced by an inhibition of the clearance of triglyceride. The slower rate of lipolysis may cause the accumulation of cholesterol in TRL.
authors.affiliation: National Research Programme for Nutritional Intervention, South African Medical Research Council, Tygerberg.
authors.forename: K I
authors.initials: KI
authors.lastname: Grant
authors.forename: M P
authors.initials: MP
authors.lastname: Marais
authors.forename: M A
authors.initials: MA
authors.lastname: Dhansay
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D013395:Sucrose / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005217:Fat Emulsions, Intravenous; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D013395:Sucrose; D002784:Cholesterol