p53 protein expression in mammary and extramammary Paget's disease.
p53 is a tumour-suppressor gene, mutations of which are found in malignant skin lesions. We studied the immunohistochemical expression of the (mutated) p53 protein in 17 cases of Paget's disease (12 mammary and 5 extramammary). Four of the mammary specimens (33.3%) expressed p53 within Paget's cells; in one of these an underlying ductal adenocarcinoma was present and this was also p53-positive. All extramammary cases proved p53-negative. These results underline the differences that exist between mammary and extramammary Paget's disease and favour the origin of the former from the underlying adenocarcinoma rather than the surface epithelium.
Kanitakis
J
J
Department of Dermatology, Hôpital Ed. Herriot (Pav. R), Lyon, France.
Thivolet
J
J
Claudy
A
A
D002467:Cell Nucleus / Q000737:chemistry; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000737:chemistry*; D010144:Paget's Disease, Mammary / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53