Myocardial ischemia after 5-fluorouracil chemotherapy.
A 40-year-old male patient with carcinoma of the tonsil was put on a 5-fluorouracil and cisplatinum regimen. On day 2 during 5-fluorouracil infusion, he had features of myocardial ischemia manifesting as angina and ST-elevation in ECG. These vasospastic ischemic changes subsided after nitroglycerine plus nifedipine therapy. Such vasospastic toxicity of 5-fluorouracil is rare and few such cases have been reported.
Rastogi
N
N
Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Chag
M
M
Ayyagari
S
S
D000328:Adult; D002277:Carcinoma / Q000188:drug therapy; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced*; D014067:Tonsillar Neoplasms / Q000188:drug therapy
D005472:Fluorouracil