title: [Veno-occlusive disease after liver transplantation. Association of acute cellular rejection and toxicity of azathioprine].
abstract: Azathioprine vascular hepatotoxicity has been described mainly after renal transplantation. We report a new case in a patient who developed veno-occlusive disease of the liver 3 weeks after liver transplantation; regression of lesions were observed after discontinuation of azathioprine therapy. In this case, azathioprine hepatotoxicity may have been enhanced by a previous episode of severe, acute rejection prevailing in the hepatic veins. After liver transplantation, the diagnosis of azathioprine hepatotoxicity is difficult but should be suspected in the presence of non-inflammatory small hepatic veins lesions. Early withdrawal of the drug is mandatory for complete recovery.
authors.affiliation: Unité de Transplantation Hépatique, Hôpital Edouard-Herriot, Lyon.
authors.forename: F
authors.initials: F
authors.lastname: Mion
authors.forename: P
authors.initials: P
authors.lastname: Cloix
authors.forename: O
authors.initials: O
authors.lastname: Boillot
authors.forename: D
authors.initials: D
authors.lastname: Gille
authors.forename: R
authors.initials: R
authors.lastname: Bouvier
authors.forename: P
authors.initials: P
authors.lastname: Paliard
authors.forename: F
authors.initials: F
authors.lastname: Berger
mesh_terms: D000208:Acute Disease; D001379:Azathioprine / Q000633:toxicity*; D001706:Biopsy; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000150:complications* / Q000473:pathology; D006504:Hepatic Veno-Occlusive Disease / Q000097:blood / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D001379:Azathioprine
vernacular_title: Maladie veino-occlusive après transplantation hépatique. Association d'un rejet aigu cellulaire et de la toxicité de l'azathioprine.