[The increase in endocytosis of mouse skeletal muscle after denervation and the proliferation of satellite cells].
The relationship between increase of endocytosis and proliferation of satellite cells in mouse skeletal muscle was studied by biochemical and culture methods in vitro. The results indicated that: (1) 4 d or 6 d after denervation, increase of endocytosis and proliferation of satellite cells in denervated muscle were induced. (2) Actinomycin D inhibited activation of satellite cells and endocytosis in normal muscle. (3) While in denervated muscle, actinomycin D inhibited proliferation of satellite cells as well as increase of endocytosis, but could not prevent muscle atrophy after denervation. These results imply that proliferation of satellite cells and increase of endocytosis in the muscle may concur to the appearance of some factors after denervation, or increase in endocytosis is a mere result of proliferation of satellite cells.
Tian
W H
WH
Shanghai Institute of Physiology, Chinese Academy of Sciences.
Gu
J F
JF
Qian
B H
BH
Rong
Q
Q
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D004705:Endocytosis; D008297:Male; D051379:Mice; D009121:Muscle Denervation; D009132:Muscles / Q000166:cytology*