[Antibiotic prophylaxis in cardiovascular surgery: comparison of sulbactam-ampicillin and cefuroxime].
A total of 200 patients (131 males and 69 females), scheduled for cardiovascular surgery were randomly assigned to receive either sulbactam/ampicillin 1 g IV of cefuroxime 2 g IV before the surgical incision and then, postoperatively, 8-hourly x 3 days. There were five failure of prophylaxis (all in the cefuroxime group): 3 sternal incision abscesses (1 Pseudomonas aeruginosa and 2 Staphylococcus epidermidis), one urinary tract infection (Staphylococcus aureus) and one Micrococcus pneumoniae. Tolerance to both antibiotics was excellent. In our sample of patients, the efficacy and safety of sulbactam/ampicillin were not different from those of cefuroxime in prophylaxis in cardiovascular surgery.
Girotto
M
M
Cattedra di Cardiochirurgia, Università degli Studi di Torino.
Comoglio
C
C
Donegani
E
E
Di Summa
M
M
D000667:Ampicillin / Q000009:adverse effects / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000601:surgery*; D002444:Cefuroxime / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013407:Sulbactam / Q000009:adverse effects / Q000627:therapeutic use
C035444:sultamicillin; D000667:Ampicillin; D002444:Cefuroxime; D013407:Sulbactam
Profilassi antibiotica in chirurgia cardiovascolare: confronto fra sulbactam/ampicillina e cefuroxima.