[Study of combinations of antimicrobial agents. Development of the method].
We developed and validated a micromethod similar to the checkerboard method in antibiotherapy to study the efficiency of antiseptic and disinfectant molecules. The determination of the FBC index (Fractional Bactericidal Concentration) on 4 reference strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae) for 4 associations (2-benzyl-4 chlorophenol--iodophor; cetrimide-iodophor, 2 benzyl-4 chlorophenol--formaldehyde; hexamidine--formaldehyde) revealed 2 synergistic associations and 2 antagonistic associations for one or more strains.
Martin
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CNEVA, Laboratoire des médicaments vétérinaires, La Haute-Marche, Javene.
Maris
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001550:Benzamidines / Q000494:pharmacology; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology*; D004003:Dichlorophen / Q000031:analogs & derivatives* / Q000494:pharmacology; D004336:Drug Antagonism; D004338:Drug Combinations; D004357:Drug Synergism; D016983:Enterococcus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005557:Formaldehyde / Q000494:pharmacology*; D066298:In Vitro Techniques; D007455:Iodine / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001550:Benzamidines; D002593:Cetrimonium Compounds; D004338:Drug Combinations; D005557:Formaldehyde; C018961:hexamidine; C004660:clorophene; D007455:Iodine; D004003:Dichlorophen; D000077286:Cetrimonium
Etude des associations d'agents antimicrobiens. Mise au point de méthode.