title: [Definitive end-stage chronic kidney failure after cisplatin treatment].
abstract: Renal failure secondary to CDDP is due to acute tubular necrosis and is usually reversible. We report 4 cases of definitive renal failure secondary to administration of cisplatin (CDDP). Three women and one man, mean age 40 +/- 8 years (24 to 64 years), at onset of dialysis are reported. They had received 1 to 4 courses of CDDP for an endometrial carcinoma (n = 2), a breast carcinoma or a thymoma. The mean total dose of CDDP was 447 +/- 169 mg (160 to 900 mg). There was no additional nephrotoxic drug. Before treatment serum creatinine concentration was normal (77 +/- 7 mumol per liter) in all patients. In 2 cases dehydration (due to vomiting and use of mannitol) occurred during CDDP treatment. One patient was treated 30 days after a nephrectomy. At the onset of dialysis, renal ultrasound was normal. In 3 cases dialysis was necessary within 15 days following chemotherapy. In one case renal function deteriorated progressively to end stage renal failure 12 months after CDDP treatment. Dialysis was performed in 3 cases by hemodialysis and in one patient by peritoneal dialysis. All patients remained more than 6 months on dialysis. Three patients died from their cancer. One patient, being considered cured from his thymoma, is currently being evaluated for a kidney transplantation. Our observations outline the potential severity of CDDP nephrotoxicity. Systemic hydration with serial serum creatinine measurements are mandatory during and after CDDP administration these patients.
authors.affiliation: Service de Néphrologie, Hôpital Pittié-Salpêtrière, Paris.
authors.forename: G
authors.initials: G
authors.lastname: Brillet
authors.forename: G
authors.initials: G
authors.lastname: Deray
authors.forename: M
authors.initials: M
authors.lastname: Lucsko
authors.forename: C
authors.initials: C
authors.lastname: Faucher
authors.forename: P
authors.initials: P
authors.lastname: Aubert
authors.forename: J
authors.initials: J
authors.lastname: Rottembourg
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000628:therapy; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D006435:Renal Dialysis
chemical_list: D002945:Cisplatin
vernacular_title: Insuffisance rénale chronique terminale définitive après traitement par le cisplatine.