Comparative bioequivalence study of different brands of acetyl salicylic acid in human volunteers.
A double blind cross over randomized study was conducted in 7 normal healthy volunteers. Single dose (700 mg) of buffered aspirin or aspirin with calcium carbonate or aspirin with caffeine was administered orally, at least 3 days apart. Blood samples were drawn at different time intervals after administration of drug for estimation of salicylate levels. The values of different pharmacokinetic parameters (AUC0-infinity, Cmax and tmax) did not show any significant difference, suggesting that these three brands of aspirin are biologically equivalent.
Valecha
N
N
Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.
Gupta
U
U
Mehta
V L
VL
D000328:Adult; D001241:Aspirin / Q000145:classification / Q000493:pharmacokinetics*; D002110:Caffeine; D002119:Calcium Carbonate; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid; D013810:Therapeutic Equivalency
D012459:Salicylates; D002110:Caffeine; D002119:Calcium Carbonate; D020156:Salicylic Acid; D001241:Aspirin