title: Cytogenetic findings in primary uveal melanoma.
abstract: We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.
authors.affiliation: Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: A D
authors.initials: AD
authors.lastname: Singh
authors.forename: L
authors.initials: L
authors.lastname: Boghosian-Sell
authors.forename: K K
authors.initials: KK
authors.lastname: Wary
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: P
authors.initials: P
authors.lastname: De Potter
authors.forename: L A
authors.initials: LA
authors.lastname: Donoso
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: L A
authors.initials: LA
authors.lastname: Cannizzaro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000235:genetics* / Q000473:pathology