Monoclonal cytoplasmic immunoglobulin and pathomorphological reactions in lymph nodes in spontaneous bovine leukemia virus infection.
Prescapular lymph nodes from 109 cows seropositive to bovine leukemia virus (BLV) were examined for the presence of light chains of bovine immunoglobulin (Ig) kappa or lambda. A variety of reactions were present in prescapular lymph nodes, including B-zonal hyperplasia (23 cases, 21.1%), T-zonal hyperplasia (52 cases, 47.7%), mixed hyperplasia (18 cases, 16.5%), pulp proliferation (six cases, 5.5%), and atrophy (ten cases, 9.2%). In the case of pulp proliferation the immunohistological examination identified only Ig of a single light chain type lambda. The possible relationship of a monoclonal expression of Ig and development of tumorous proliferation is discussed in the study.
Levkut
M
M
Department of Pathological Anatomy, University of Veterinary Medicine, Kosice, Slovakia.
Plank
L
L
Levkutova
M
M
Konrád
V
V
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D003593:Cytoplasm / Q000276:immunology; D016583:Enzootic Bovine Leukosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007145:Immunoglobulin kappa-Chains / Q000276:immunology*; D007146:Immunoglobulin lambda-Chains / Q000276:immunology*; D001909:Leukemia Virus, Bovine / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology
D000914:Antibodies, Viral; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains