Transcervical CVS sample size: correlation with placental location, cytogenetic findings, and pregnancy outcome.
Data from 2907 transcervical CVS cases performed on singleton pregnancies were reviewed retrospectively and villus sample size was correlated with cytogenetic results, placental location, maternal age at the expected date of confinement (EDC), gestational age at the time of sampling, birth weight, gestational age at the time of delivery, and pregnancy outcome. No correlation was noted between villus sample size and maternal age, gestational age at sampling, gestational age at delivery, birth weight, or pregnancy outcome. An inverse correlation between villus sample size and percentage of abnormal cytogenetic findings was statistically significant (chi 2 = 8.53, p < 0.01). The percentage of small samples was greater when the placenta was anterior, lateral, or fundal than when the placenta was posterior.
McIntosh
N
N
Prenatal Diagnostic Center of Southern California, Inc., Beverly Hills 90211.
Rubin
C
C
Wang
B
B
Williams
J
J
D000328:Adult; D002584:Cervix Uteri; D015193:Chorionic Villi Sampling / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D007621:Karyotyping; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies