title: Tumour affinity of 203Pb-chloride: comparison with 67Ga-citrate and 201Tl-chloride.
abstract: The radionuclide 203Pb decays completely by electron capture to stable 203Tl with a half-life of 52 h. The primary radiation from the decay is gamma-ray radiation 280 keV (80%). 203Pb is produced easily from the natural metal thallium by the method described below. 203Pb-chloride is a promising imaging agent for tumour scanning because of the large retention value for tumour tissue and the small value for normal organs, but the large value for the kidney and bone is a shortcoming when considering it as an imaging agent. The retention value of 203Pb in tumour tissue is larger than that of 201Tl and smaller than that of 67Ga. The tumour/inflammatory lesion retention ratio for 203Pb is very large in comparison with those for 67Ga and 201Tl. 203Pb accumulates to a large extent in viable tumour tissue, and less in necrotic tumour tissue and in inflammatory lesion. Therefore, 203Pb-chloride is far better for visualization of viable tumour tissue than 67Ga and 201Tl if the large retention values for the kidney and bone were reduced.
authors.affiliation: School of Allied Medical Professions, Kanazawa University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ando
authors.forename: L
authors.initials: L
authors.lastname: Shaolin
authors.forename: I
authors.initials: I
authors.lastname: Ando
authors.forename: S
authors.initials: S
authors.lastname: Sanada
authors.forename: T
authors.initials: T
authors.lastname: Hiraki
authors.forename: K
authors.initials: K
authors.lastname: Hisada
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Kurosaki
authors.forename: K
authors.initials: K
authors.lastname: Nitta
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000818:Animals; D002951:Citrates / Q000493:pharmacokinetics; D019343:Citric Acid; D005710:Gallium Radioisotopes; D007854:Lead / Q000493:pharmacokinetics; D007856:Lead Radioisotopes; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013793:Thallium / Q000493:pharmacokinetics; D013794:Thallium Radioisotopes
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D007856:Lead Radioisotopes; D013794:Thallium Radioisotopes; D019343:Citric Acid; D007854:Lead; C027549:thallium chloride; C029891:lead chloride; D013793:Thallium