Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol-10 and polyunsaturated fatty acid content.
At an early stage of oxidation induced by Cu2+, the rate of oxidative modification of human low density lipoprotein (LDL) from healthy donors correlated negatively to its ubiquinol-10 (r = -0.58, P < 0.01) and positively to its polyunsaturated fatty acid (PUFA) (r = 0.53, P < 0.05) content. The PUFA/ubiquinol-10 ratio was the best predictor of LDL susceptibility to oxidation (r = 0.68, P < 0.01). No significant correlation between LDL oxidizability and its alpha-tocopherol content was found at any oxidation stage. It is suggested that ubiquinol-10 plays a central role in the early protection of LDL PUFAs against Cu(2+)-induced oxidation whereas alpha-tocopherol posesses both pro- and antioxidant activity.
Kontush
A
A
Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
Hübner
C
C
Finckh
B
B
Kohlschütter
A
A
Beisiegel
U
U
D000328:Adult; D003300:Copper / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D008077:Lipoproteins, LDL; D014451:Ubiquinone; C026663:ubiquinol-10; D003300:Copper