title: Increasing incidence of adenovirus disease in bone marrow transplant recipients.
abstract: Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, < 30 days) than in adults (> 90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee County Medical Center, Children's Hospital of Wisconsin, Milwaukee 53226.
authors.forename: P
authors.initials: P
authors.lastname: Flomenberg
authors.forename: J
authors.initials: J
authors.lastname: Babbitt
authors.forename: W R
authors.initials: WR
authors.lastname: Drobyski
authors.forename: R C
authors.initials: RC
authors.lastname: Ash
authors.forename: D R
authors.initials: DR
authors.lastname: Carrigan
authors.forename: G V
authors.initials: GV
authors.lastname: Sedmak
authors.forename: T
authors.initials: T
authors.lastname: McAuliffe
authors.forename: B
authors.initials: B
authors.lastname: Camitta
authors.forename: M M
authors.initials: MM
authors.lastname: Horowitz
authors.forename: N
authors.initials: N
authors.lastname: Bunin
mesh_terms: D000258:Adenovirus Infections, Human / Q000453:epidemiology* / Q000209:etiology; D000260:Adenoviruses, Human / Q000145:classification / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000741:Anemia, Aplastic / Q000601:surgery; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D015994:Incidence; D007223:Infant; D007938:Leukemia / Q000601:surgery; D008223:Lymphoma / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012703:Serotyping; D013997:Time Factors