Repression versus activation in the control of gene transcription.
Studies on the regulation of transcription often focus on mechanisms of transcriptional activation. However, transcriptional repression is also an important factor in the regulation of many genes. Transcription of specific genes can be downregulated in various ways, and examination of a number of different systems has revealed that most or all steps required for transcriptional activation can be interfered with by transcriptional repressors.
Cowell
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Department of Biochemistry and Genetics, Medical School, University of Newcastle Upon Tyne, UK.
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000737:chemistry / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014158:Transcription, Genetic / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology*
D004268:DNA-Binding Proteins; D012097:Repressor Proteins