title: Transient adult T-cell leukemia/lymphoma picture during varicella infection in an HTLV-1 carrier.
abstract: HTLV-1 (human T-lymphotropic virus type 1) is associated with tropical spastic paraparesis, adult T-cell lymphoma (ATL), and also with opportunistic infections. The risk for developing ATL in HTLV-1 healthy carriers is low, between 1 and 4%. Nothing is known about the events promoting the evolution from the healthy carrier state to symptomatic ATL. We describe the case of a 44-year-old French Caribbean man with a chronic and recurrent strongyloidiasis in which the occurrence of a hemorrhagic and necrotic varicella led to the discovery of an infection by HTLV-1 and an acute form of ATL. All hematological data were normal before the onset of varicella. ATL completely disappeared at the same time as the varicella healed. This leads us to hypothesize that acute infections such as the reactivation of varicella-zoster may act as a promoting factor for the development of ATL in healthy HTLV-1 carriers.
authors.affiliation: Unit of Research on Hepatitis, AIDS and Human Retroviruses, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: D'Incan
authors.forename: P
authors.initials: P
authors.lastname: Combemale
authors.forename: B
authors.initials: B
authors.lastname: Verrier
authors.forename: D
authors.initials: D
authors.lastname: Garin
authors.forename: G
authors.initials: G
authors.lastname: Audoly
authors.forename: J
authors.initials: J
authors.lastname: Brunot
authors.forename: C
authors.initials: C
authors.lastname: Desgranges
authors.forename: A
authors.initials: A
authors.lastname: Fléchaire
mesh_terms: D000328:Adult; D002644:Chickenpox / Q000150:complications*; D004279:DNA, Viral / Q000302:isolation & purification; D015490:HTLV-I Infections / Q000175:diagnosis*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008297:Male; D016133:Polymerase Chain Reaction; D013322:Strongyloidiasis / Q000150:complications*
chemical_list: D004279:DNA, Viral