title: Biochemical effects of viscoelastic materials on the glycosaminoglycans in the organ-cultured rabbit trabecular meshwork.
abstract: We studied the effects of viscoelastic materials on the glycosaminoglycan (GAG) profiles in the organ-cultured rabbit trabecular meshwork (TM). The cultured specimens were divided into 4 groups: (1) control group; (2) 1% sodium hyaluronate-(Na-HA)-treated group; (3) 3% chondroitin-6-sulfate (CD6S)-treated group, and (4) 1% methylcellulose (MC)-treated group. They were cultured for 2 weeks and subjected to sequential enzymatic degradation. In the 1% Na-HA-treated group, the proportion of hyaluronic acid was significantly increased compared with the control group. In the 3% CD6S-treated group, the proportion of chondroitin sulfate was significantly increased compared with the control group. In the 1% MC-treated group, the GAG profile did not differ from the control profile.
authors.affiliation: Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tofukuji
mesh_terms: D000818:Animals; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008297:Male; D008747:Methylcellulose / Q000494:pharmacology*; D009924:Organ Culture Techniques; D011817:Rabbits; D014129:Trabecular Meshwork / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
chemical_list: D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D008747:Methylcellulose; D002809:Chondroitin Sulfates