Pleurodesis with polidocanol in pigs. An experimental study.
Polidocanol was instilled in five pleural cavities of three pigs. Adhesions formed in all. Adhesion distribution varied from covering a minor part to most of the lung, depending on the amount of polidocanol. One control cavity treated with sodium chloride was unaffected. Microscopy showed fibrous bridges between the pleural layers and mild submesothelial fibrosis and inflammation.
Gade
J
J
Institute for Experimental Research in Surgery, Panum Institute, Albertslund, Denmark.
Brasso
K
K
Junge
J
J
Olesen
H P
HP
D000818:Animals; D005260:Female; D010994:Pleura / Q000187:drug effects*; D011030:Pneumothorax / Q000628:therapy*; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D015911:Sclerotherapy / Q000379:methods; D013552:Swine; D000267:Tissue Adhesions / Q000473:pathology
D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols