title: High viscosity hydroxypropylmethylcellulose reduces postprandial blood glucose concentrations in NIDDM patients.
abstract: The ability of high viscosity hydroxypropylmethylcellulose (HPMC) to reduce postprandial glucose concentrations was assessed in patients with non-insulin-dependent diabetes (NIDDM) and healthy volunteers. The study design consisted of a two-way crossover, single-dose administration of 10 g prehydrated high viscosity HPMC, or placebo, with a standard carbohydrate-rich meal. In patients with NIDDM, HPMC reduced blood glucose concentrations at the 60-, 75-, 90-, 120- and 150-min sampling intervals, with an average reduction in the maximum postprandial blood glucose concentration, Cmax, of 24% (P < 0.05). The time at which the maximum concentration was reached, Tmax, remained unchanged. The area under the blood concentration versus time plot, AUC0-6h, was reduced by an average of 15% (P < 0.05). The blood concentration profile of insulin followed that of glucose. Concentrations were significantly lower than in the placebo phase only at the 120-min sampling time, while pharmacokinetic parameters (Cmax, Tmax and AUC0-6h) were unchanged. These results suggest that alterations in the blood glucose profile are mediated by luminal events rather than by changes in hormonal response. In contrast to the NIDDM patients, neither the pharmacokinetic parameters nor the blood glucose concentrations at specific sampling times were significantly affected by the co-administration of HPMC in healthy volunteers. Overall, the results of this study suggest that HPMC may be a useful adjunct in the management of NIDDM.
authors.affiliation: Department of Pharmacy, University of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Reppas
authors.forename: C H
authors.initials: CH
authors.lastname: Adair
authors.forename: J L
authors.initials: JL
authors.lastname: Barnett
authors.forename: R R
authors.initials: RR
authors.lastname: Berardi
authors.forename: D
authors.initials: D
authors.lastname: DuRoss
authors.forename: S Z
authors.initials: SZ
authors.lastname: Swidan
authors.forename: P F
authors.initials: PF
authors.lastname: Thill
authors.forename: S W
authors.initials: SW
authors.lastname: Tobey
authors.forename: J B
authors.initials: JB
authors.lastname: Dressman
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004435:Eating; D005260:Female; D006801:Humans; D065347:Hypromellose Derivatives; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D008875:Middle Aged; D012016:Reference Values; D013997:Time Factors; D014783:Viscosity
chemical_list: D000924:Anticholesteremic Agents; D001786:Blood Glucose; D007328:Insulin; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D002784:Cholesterol