Use of quantitative CT to predict postoperative lung function in patients with lung cancer.
OBJECTIVE
To evaluate the effectiveness of quantitative computed tomography (CT) for predicting postoperative lung function in patients with lung cancer.


METHODS
Preoperative spirometry and conventional CT of the chest were performed in 38 patients. A postprocessing CT program was applied to quantitate the volume of whole-lung parenchyma with attenuations of -500 to -910 HU; this was defined as total functional lung volume (TFLV). The regional functional lung volume (RFLV) of the lobes or lung to be resected was quantitated separately. CT-predicted postoperative forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were derived by multiplying the preoperative spirometry values by (1 - RFLV/TFLV).


RESULTS
CT-predicted values correlated well with postoperatively measured results (FEV1: r = .93, P < .001; FVC: r = .86, P < .001) in patients who underwent pneumonectomy or lobectomy, regardless of the patient's preoperative ventilation status.


CONCLUSIONS
This method is effective in the prediction of postoperative FEV1 and FVC in patients undergoing pulmonary resection.
Wu
M T
MT
Department of Radiology, Kaohsiung Veterans General Hospital, Taiwan, Republic of China.
Chang
J M
JM
Chiang
A A
AA
Lu
J Y
JY
Hsu
H K
HK
Hsu
W H
WH
Yang
C F
CF
D000368:Aged; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects; D011237:Predictive Value of Tests; D012120:Respiration Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D015656:Respiratory Mechanics; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity