title: [The use of the preparation bonefos in the combined therapy of multiple myeloma patients].
abstract: A clinical trial of a new drug bonefos (Leiras, Finland) in 13 patients with multiple myeloma confirmed its potent analgetic effect. Alleviation of ostealgia was seen as early as the treatment day 5-7. The drug inhibits the progression of skeletal tumor growth, reduces the frequency of bone fractures, normalizes calcium concentrations in the blood and urine. Side effects such as nausea and short-term epigastric pains occurred in 23% and 15.38% of the patients, respectively.
authors.forename: K M
authors.initials: KM
authors.lastname: Abdulkadyrov
authors.forename: S S
authors.initials: SS
authors.lastname: Bessmel'tsev
mesh_terms: D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D002214:Capsules; D004002:Clodronic Acid / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism; D012074:Remission Induction; D013997:Time Factors
chemical_list: D000700:Analgesics; D002214:Capsules; D004002:Clodronic Acid
vernacular_title: Primenenie preparata bonefos v kompleksnoĭ terapii bol'nykh mnozhestvennoĭ mielomoĭ.