Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers.
The effect of pretreatment with cimetidine (1 g day-1, 7 days) and of probenecid (1 g twice daily, 4 days) on the pharmacokinetics of tenoxicam (single oral dose, 20 mg) was studied in six healthy volunteers. Cmax was increased significantly when tenoxicam was given with probenecid (2.8 micrograms ml-1 alone, 3.5 micrograms ml-1 after probenecid; P < 0.005). No other pharmacokinetic parameters were altered significantly by either drug. It is concluded that neither cimetidine nor probenecid affects the pharmacokinetics of tenoxicam in a clinically important way.
Day
R O
RO
Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.
Geisslinger
G
G
Paull
P
P
Williams
K M
KM
D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D011339:Probenecid / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D002927:Cimetidine; D011339:Probenecid; C032801:tenoxicam