title: Disruption of neuronal migration in the neocortex of the dreher mutant mouse.
abstract: To analyze developmental abnormalities related to neuronal migration in the dreher mutant mouse, the neocortical cytoarchitecture of dreher and control mice were examined in Nissl-stained serial sections by light microscopy. In general, the dreher neocortex has six layers which are similar in size and thickness to those observed in normal mouse neocortex. However, in dreher neocortex, three types of abnormalities were found: (1) an increase in the number of diffusely distributed neurons in layer I, (2) small, ectopic collections of neurons in layer I, and (3) isolated disturbances of local cytoarchitecture characterized by neuron-free space distributed in areas between layer II to IV. The occurrence of small, punctate deficits in the dreher neocortex may be secondary to disruptions of the radial glial fiber system and neuronal migration. The fact that cytoarchitectonic abnormalities of several types were found in the dreher neocortex may be useful in analyzing the relationship between radial glial fibers and migrating young neurons, the synaptic connections which are formed by ectopically situated neurons, and the mechanism of formation of sporadically distributed neocortical abnormalities.
authors.affiliation: Department of Morphology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Shimai
authors.forename: G
authors.initials: G
authors.lastname: Huang
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: R S
authors.initials: RS
authors.lastname: Nowakowski
mesh_terms: D000818:Animals; D002465:Cell Movement; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000033:anatomy & histology*; D009474:Neurons / Q000473:pathology / Q000502:physiology*