title: Ankyrin inhibits binding of erythrocyte spectrin to phospholipid vesicles.
abstract: The studies on binding of erythrocyte spectrin to frozen and thawed phospholipid liposomes and its inhibition by ankyrin were performed. It was found that ankyrin inhibited up to 60% binding of spectrin by phosphatidylethanolamine/phosphatidylcholine vesicles. It was able to dissociate up to 40% of spectrin from this complex. Ankyrin inhibition of binding of phosphatidylserine/phosphatidylcholine vesicles by spectrin, although much lower, was also observed.
authors.affiliation: University of Wrocław, Institute of Biochemistry, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Białkowska
authors.forename: A
authors.initials: A
authors.lastname: Zembroń
authors.forename: A F
authors.initials: AF
authors.lastname: Sikorski
mesh_terms: D000818:Animals; D017487:Ankyrins / Q000494:pharmacology*; D001665:Binding Sites; D002417:Cattle; D004910:Erythrocyte Membrane / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D013049:Spectrin / Q000378:metabolism*
chemical_list: D017487:Ankyrins; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D013049:Spectrin