[Acute anicteric hepatitis and intrahepatic cholestasis caused by administration of prajmalium bitartrate (Neo-Gilurytmal)].
The authors draw attention to a serious drug response to the derivative of the alkaloid ajmaline prajmalium (Neo-Gilurytmal, Giulini-GFR) which causes impairment of liver functions of various grades as a result of intrahepatic cholestasis. They draw attention to the necessity of a careful pharmacological case-history, evaluation of the premorbid stage, in particular former liver disease or contemporary administration of drugs which burden liver function (hormonal contraceptives, non-steroid antirheumatic drugs). It is essential to follow-up liver functions by laboratory tests already at the onset of treatment with Neo-Gilurytmal.
Trefanec
J
J
1. interní klinika 2. LF UK, Praha.
Langmeierová
M
M
Zelezná
J
J
D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D006801:Humans; D008297:Male; D011219:Prajmaline / Q000009:adverse effects*
D011219:Prajmaline
Akutní anikterická hepatitida s intrahepatální cholestázou vyvolaná podáváním prajmalium bitartarátu (Neo-Gilurytmal).