Effect of depletion of glutathione by buthionine sulfoximine on lipid peroxidation in rats acutely treated with ethanol.
1. The effect of depletion of glutathione (GSH) by DL-buthionine-S,R-sulfoximine (BSO) on lipid peroxidation in rats acutely treated with ethanol was investigated. 2. BSO pretreatment has not been found to potentiate an increase in liver, brain and erythrocyte lipid peroxide levels.
Koçak-Toker
N
N
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
Mutlu-Türkoğlu
U
U
Alptekin
N
N
Uysal
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019328:Buthionine Sulfoximine; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005978:Glutathione / Q000172:deficiency*; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D008717:Methionine Sulfoximine; D000431:Ethanol; D019328:Buthionine Sulfoximine; D005978:Glutathione