title: Protease-dependent virus tropism and pathogenicity.
abstract: Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.
authors.affiliation: Dept of Viral Infection, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D010450:Endopeptidases / Q000378:metabolism*; D008969:Molecular Sequence Data; D014760:Viral Fusion Proteins / Q000378:metabolism*; D014780:Viruses / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D014760:Viral Fusion Proteins; D010450:Endopeptidases