In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species.
Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.
Müller-Jakic
B
B
Institut für Pharmazeutische Biologie der Universität München, Federal Republic of Germany.
Breu
W
W
Pröbstle
A
A
Redl
K
K
Greger
H
H
Bauer
R
R
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D012756:Sheep; D013552:Swine
D000577:Amides; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors