Comparative studies on IL-6 production status in HTLV-1 chronically infected cell lines derived from different HTLV-1 associated pathologies.
We have comparatively studied the qualitative and quantitative status of Interleukin 6 (IL-6) production in several HTLV-1 chronically infected T-cell lines derived from patients suffering either of adult-T-cell leukemia/lymphoma or of tropical spastic paraparesis (TSP). Two other HTLV-1 chronically infected cell lines, coming from healthy seropositive carriers, were also analyzed. Our results demonstrate that, independently of the origin, all these T cell lines, as compared to uninfected HTLV-1 T cell ones, which were always IL-6 non producers, synthesize and yield comparable amounts of IL-6 synthesis, he nosological origin of infecting viral strains does not seem to play a differential role on IL-6 qualitative or quantitative production parameters.
Saib
A
A
UPR A0043 CNRS, Hôpital Saint Louis, Paris, France.
Saal
F
F
Giron
M L
ML
Valla
J
J
Hojman
F
F
Peries
J
J
Canivet
M
M
D015152:Blotting, Northern; D002460:Cell Line; D005455:Fluorescent Antibody Technique; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics
D015850:Interleukin-6