[Erythropoietin for autologous transfusion. Use in a case of severe anemia with allo-immunization].
In view of the transfusional risks of viral transmission (notably HIV), autologous transfusion is increasingly used; it is often the only possible type of transfusion. A 42-year-old woman with lupus erythematosus, chronic renal failure and triple cardiac valve disease demanding surgery was admitted for multifactorial severe anaemia. Treatment with erythropoietin (8000 units/day) iron replenishment, corticosteroids and polyvalent immunoglobulins was initiated. The patient was operated upon in April 1990. A preoperative cell-saver autotransfusion was performed during surgery. The postoperative period was uneventful. Homologous transfusion was not necessary. In this case where homologous transfusion was ruled out, erythropoiesis stimulated by erythropoietin enabled autotransfusion and cardiac surgery to be performed.
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Département de Néphrologie, Hôpital Necker, Paris.
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Mauriat
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D000328:Adult; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000601:surgery; D001804:Blood Transfusion, Autologous / Q000379:methods*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007676:Kidney Failure, Chronic / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000601:surgery; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000601:surgery
D004921:Erythropoietin
Erythropoiétine pour transfusion autologue. Utilisation dans un cas d'anémie grave avec allo-immunisation.