Early postnatal growth of skeletal muscle blood vessels of the rat.
The development of blood vessels during the first three postnatal weeks was studied in the ventral stripe of the spinotrapezius muscle of the rat by use of India ink-gelatine injections, and electron microscopy. The number of terminal arterioles and collecting venules remained unchanged postnatally in the observed area. A remarkable proximodistal gradient of vascular development was apparent: while the basic structure of the hilar vessels remained unchanged in the time studied, the intramuscular arteries and veins matured gradually. More peripherally, gradual maturation of terminal and precapillary arterioles was observed. The capillary endothelium and the pericytes showed immature features, and remained unchanged during the time studied. An intense rebuilding activity was found in the endothelial cells of the growing venules, expressed by various forms of gaps, covered by an intact basal lamina and pericytes. Numerous mast cells and macrophages were found along all vessels. Intramuscular lymphatics were not present prior to the first postnatal week.
Stingl
J
J
Department of Anatomy, First Medical School, Charles University, Prague, Czech Republic.
Rhodin
J A
JA
D000818:Animals; D000831:Animals, Newborn; D001158:Arteries / Q000254:growth & development / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000254:growth & development / Q000648:ultrastructure; D005260:Female; D008297:Male; D008833:Microcirculation / Q000254:growth & development / Q000648:ultrastructure; D008854:Microscopy, Electron; D008955:Models, Cardiovascular; D024510:Muscle Development; D009132:Muscles / Q000098:blood supply*; D051381:Rats; D017208:Rats, Wistar; D014680:Veins / Q000254:growth & development / Q000648:ultrastructure