title: [Malignant mesothelioma: study of prognostic factors in a series of 188 cases].
abstract: From 1973 to 1990, 188 patients with pleural malignant mesothelioma entered a prospective study of this disease to assess the main prognostic factors. All had undergone thoracoscopy with endoscopic description of lesions, and multiple biopsies. The diagnostic yield of thoracoscopy was 98.4%. Multivariate analysis of main clinical, histopathological, endoscopic and radiological (including CT-scan) parameters was performed according to Cox's model. The most favorable factors were: absence of weight loss at the time of diagnosis, absence of involvement of the visceral pleural, Butchart stage I and epithelial histopathological type. Thoracoscopy allowed early diagnosis of the disease and a subdivision of Butchart stage I into stage IA (with normal visceral pleura) and stage IB (with invaded visceral pleural): median survivals are 32.7 and 7 months respectively. Like CT scan, thoracoscopy is therefore necessary in the staging of malignant mesothelioma.
authors.affiliation: Service de Pneumologie, Institut Paoli-Calmettes, Marseille.
authors.forename: J R
authors.initials: JR
authors.lastname: Viallat
authors.forename: C
authors.initials: C
authors.lastname: Boutin
authors.forename: F
authors.initials: F
authors.lastname: Rey
authors.forename: P
authors.initials: P
authors.lastname: Astoul
authors.forename: P
authors.initials: P
authors.lastname: Farisse
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D008297:Male; D008654:Mesothelioma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D015999:Multivariate Analysis; D010997:Pleural Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D013906:Thoracoscopy
chemical_list: D007376:Interleukin-2; D007371:Interferon-gamma
vernacular_title: Mésothéliome malin: étude des facteurs pronostiques sur une série de 188 cas.