title: [Polypharmacotherapy: the risk of developing postoperative hemorrhages].
abstract: The impact of polypragmasy on the causes of endogenic heparinemia in the early postoperative period was studied in patients operated on the heart under extracorporeal circulation. It has been found that polypragmasy does not break down the heparin-protamine sulfate complex, but impairs the process of its formation to a certain degree. Ascorbic acid lowers the activity of heparin and hence it may be used as a hemostatic stabilizer during endogenous heparinemia.
authors.forename: I I
authors.initials: II
authors.lastname: Dement'eva
authors.forename: E V
authors.initials: EV
authors.lastname: Roĭtman
authors.forename: V M
authors.initials: VM
authors.lastname: Pechennikov
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D004359:Drug Therapy, Combination; D064420:Drug-Related Side Effects and Adverse Reactions; D005112:Extracorporeal Circulation; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D006493:Heparin / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D011485:Protein Binding / Q000187:drug effects; D012189:Retrospective Studies
chemical_list: D001798:Blood Proteins; D006493:Heparin
vernacular_title: Polifarmakoterapiia: risk razvitiia posleoperatsionnykh krovotecheniĭ.