title: In vivo fluorine-19 magnetic resonance spectroscopy of cerebral halothane in postoperative patients: preliminary results.
abstract: This study reports the use of 19F MRS to study halothane in the brain of eight patients recovering from halothane anesthesia of short duration. Resonances attributable to halothane were observed up to 90 min after withdrawal of the anesthetic agent. The signal-to-noise ratio for an unlocalized spectrum acquired using a 6 cm surface coil was typically 20 with data collection times of 2 min. In seven patients a single resonance was seen with a mean (+/- SD) chemical shift of +43.3 (+/- 1.8) ppm, referenced to NaF at 0 ppm. This resonance exhibited a T1 value of between 0.5 and 1 s, and a T2* (estimated from the linewidth of the resonance) between 3.5 and 10 ms. In one patient two resonances were observed with chemical shifts of +38 and +41 ppm. Because we cannot exclude the possibility that this was due to field inhomogeneity, the significance of the last finding is uncertain. However, phantom studies show that the chemical shift of halothane in different environments (such as water, olive oil, methanol, and lecithin) can vary to an extent that accounts for the two resonances seen in our patient. These results demonstrate the feasibility of in vivo 19F MRS studies of fluorinated volatile agents in humans. The potential for clinical 19F MRS of fluorinated anesthetics is discussed.
authors.affiliation: NMR Unit, Hammersmith Hospital, London, United Kingdom.
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
authors.forename: C J
authors.initials: CJ
authors.lastname: Peden
authors.forename: I J
authors.initials: IJ
authors.lastname: Cox
authors.forename: J
authors.initials: J
authors.lastname: Sargentoni
authors.forename: J D
authors.initials: JD
authors.lastname: Bell
authors.forename: G A
authors.initials: GA
authors.lastname: Coutts
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D001923:Brain Chemistry; D005260:Female; D005461:Fluorine; D006221:Halothane / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D008961:Models, Structural; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D005461:Fluorine; D006221:Halothane