[Carbamazepine poisoning: protracted course with development of intestinal atony and hepatic toxicity].
A 43 year-old female patient with a history of manic-depressive illness and prophylactic carbamazepine (CBZ) medication ingested a potentially lethal overdose of 20 g of the substance. Neurotoxic symptoms reached full intensity after about 24 hours. Subsequently, the patient developed a gastrointestinal atony, which proved to be refractory to treatment for several days. Moreover, there was an increase of bilirubin. Parallel to this we observed the persistence-and even intermittent re-increase--of toxic serum CBZ concentrations for one week with corresponding protracted clinical symptomatology.
Baischer
W
W
Universitätsklinik für Psychiatrie, Wien.
Wagner
A
A
Seidler
D
D
Musalek
M
M
Laggner
A
A
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D002220:Carbamazepine / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology*; D003128:Coma / Q000097:blood / Q000139:chemically induced; D062787:Drug Overdose / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000097:blood / Q000139:chemically induced*; D008657:Metabolic Clearance Rate / Q000502:physiology; D009460:Neurologic Examination / Q000187:drug effects; D010528:Peristalsis / Q000187:drug effects; D013406:Suicide, Attempted / Q000523:psychology
D002220:Carbamazepine
Intoxikation mit Carbamazepin: Protrahierter Verlauf unter Entwicklung von Darmatonie und Hepatotoxizität.