title: Lipid levels in adults with cystic fibrosis.
abstract: OBJECTIVE
  To examine the hypothesis that an energy-dense, high-fat diet, which is necessary to maintain weight in adults with cystic fibrosis, does not result in high serum cholesterol levels.
  
  
  METHODS
  Dietary, anthropometric, and biochemical data were correlated.
  
  
  METHODS
  A cystic fibrosis center in Pittsburgh, Pa.
  
  
  METHODS
  Thirty-one adults with cystic fibrosis, 50 obligate carriers of the cystic fibrosis gene, and 26 controls who did not have cystic fibrosis.
  
  
  METHODS
  Adults with cystic fibrosis had a lower mean serum cholesterol level and higher mean intakes of energy and fat than controls.
  
  
  METHODS
  Student's t test was used to determine the statistical significance between two means. Univariate correlation coefficients were determined to measure the relative intensity of association between two variables.
  
  
  RESULTS
  Mean total serum cholesterol levels in men with cystic fibrosis was 3.1 mmol/L vs 4.7 mmol/L in male controls (P < .001). Mean total serum cholesterol levels in women with cystic fibrosis was 3.2 mmol/L vs 4.3 mmol/L in female controls (P < .001). Three adults with cystic fibrosis and no signs of pancreatic insufficiency had serum cholesterol levels in the high normal range. Carriers had serum lipid levels in the same range as the controls.
  
  
  CONCLUSIONS
  The findings indicate that a high-energy, high-fat diet does not raise serum lipid levels in those patients with cystic fibrosis and pancreatic insufficiency. However, those individuals with cystic fibrosis and normal pancreatic function may be at the same risk as the general population for developing high serum lipid levels. They should have their serum lipid levels monitored and be given appropriate dietary recommendations.
authors.affiliation: Department of Epidemiology, University of Pittsburgh, PA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Slesinski
authors.forename: M F
authors.initials: MF
authors.lastname: Gloninger
authors.forename: J P
authors.initials: JP
authors.lastname: Costantino
authors.forename: D M
authors.initials: DM
authors.lastname: Orenstein
mesh_terms: D000328:Adult; D000886:Anthropometry; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications / Q000178:diet therapy / Q000235:genetics; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D010188:Exocrine Pancreatic Insufficiency / Q000097:blood / Q000150:complications; D005260:Female; D006579:Heterozygote; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008055:Lipids; D002784:Cholesterol