Oncogene regulation by growth factors.
Complementary studies on quite different eukaryotic systems are revealing that certain mitogenically important enzymes, that were previously assigned to unrelated metabolic pathways, bind and may be regulated by receptor tyrosine kinases (RTKs). A deeper understanding of the relationships between these signalling pathways promises to improve our attempts to rationalise important properties of the transformed phenotype, such as tumour growth rates, metastasis and mechanisms of cellular transformation, and thereby, it is hoped, improve prognostic, diagnostic and treatment regimes. This review briefly summarises results from our and other laboratories that have shed light on specific intracellular signalling enzymes that respond to stimulation by RTKs.
Hsuan
J J
JJ
Structural Biology Laboratory, Ludwig Institute for Cancer Research, UCL School of Medicine, London, U.K.
D002472:Cell Transformation, Viral / Q000235:genetics; D066246:ErbB Receptors / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D020690:GTPase-Activating Proteins; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases; D010740:Phospholipases / Q000502:physiology; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000502:physiology; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D014162:Transfection
D020690:GTPase-Activating Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor; D010740:Phospholipases