title: Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk.
abstract: OBJECTIVE
  To investigate the incidence and prognostic value of local brain swelling, the extent of parenchymal hypodensity, and the hyperdense middle cerebral artery sign as shown by CT within the first 5 hours after the onset of symptoms in patients with angiographically proved middle cerebral artery trunk occlusions.
  
  
  METHODS
  Fifty-three patients were studied prospectively with CT 46 to 292 minutes (median, 120; mean, 134 +/- 59) after symptom onset and scored clinically at admission and 4 weeks later. All patients were treated with recombinant tissue plasminogen activator (30 to 100 mg).
  
  
  RESULTS
  Early CT showed parenchymal hypodensity in 43 patients (81%), local brain swelling in 20 patients (38%), and hyperdensity of the middle cerebral artery trunk in 25 patients (47%). Hypodensity covering more than 50% of the middle cerebral artery territory had an 85%, local brain swelling a 70%, and the hyperdense middle cerebral artery sign a 32% positive predictive value for fatal clinical outcome. Specificity of these findings for fatal outcome was 94%, 83%, and 51%, respectively, and sensitivity was 61%, 78% and 44%, respectively.
  
  
  CONCLUSIONS
  Early CT in acute middle cerebral artery trunk occlusion is highly predictive for fatal clinical outcome if there is extended hypodensity or local brain swelling despite aggressive therapeutic attempts such as thrombolysis or decompressive surgery.
authors.affiliation: Department of Neuroradiology, University of Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: von Kummer
authors.forename: U
authors.initials: U
authors.lastname: Meyding-Lamadé
authors.forename: M
authors.initials: M
authors.lastname: Forsting
authors.forename: L
authors.initials: L
authors.lastname: Rosin
authors.forename: K
authors.initials: K
authors.lastname: Rieke
authors.forename: W
authors.initials: W
authors.lastname: Hacke
authors.forename: K
authors.initials: K
authors.lastname: Sartor
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation; D003097:Collateral Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed