A comparative study on lipid peroxidation in cerebral cortex of stroke-prone spontaneously hypertensive and normotensive rats.
1. Lipid peroxidation and membrane-related enzyme changes in the cerebral cortex of stroke-prone rats (SHRSP) and normotensive rats were examined at 5 and 20 weeks of age. 2. In vivo formation of thiobarbituric acid-reactant substances was higher in SHRSP at 20 weeks of age and in vitro generation of free malondialdehyde was greater in SHRSP brains, both at 5 and 20 weeks of age, as compared with those in WKY. 3. Membrane-associated enzymes such as Na/K-ATPase and 5'-nucleotidase activities were lower in 20-week-old SHRSP than in age-matched WKY. 4. These results indicate how very prone the SHRSP brain is toward lipid peroxidation and subsequent membrane-related enzyme changes.
Ito
H
H
Division of Pathology, Kinki University, Osaka, Japan.
Torii
M
M
Suzuki
T
T
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology; D016923:Cell Death / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000378:metabolism*; D004198:Disease Susceptibility; D005609:Free Radicals; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000502:physiology*; D008566:Membranes / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values
D005609:Free Radicals