Neuritogenesis of retinal ganglion cells is differentially promoted by target extract.
Labeled retinal ganglion cells from neonatal rats extended neurites in dissociated cell culture as a cell type-specific response to the influence of a superior collicular extract. The molecule responsible for this neuritogenic effect is soluble and non-dialysable (> 12 kDa). Nerve growth factor had a neuritogenic effect both on ganglion cells and other types of retinal cells.
Bosco
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A
IMBICE, La Plata, Argentina.
Carri
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NG
Linden
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R
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D009414:Nerve Growth Factors / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D013477:Superior Colliculi / Q000502:physiology*; D014020:Tissue Extracts / Q000494:pharmacology
D009414:Nerve Growth Factors; D014020:Tissue Extracts