title: Short-term effects of electroconvulsive treatment on the uptake of 99mTc-exametazime into brain in major depression shown with single photon emission tomography.
abstract: Fifteen patients with major depression who were being treated with bilateral electroconvulsive treatment (ECT) were investigated before and 45 min after a single ECT using split-dose Single Photon Emission Tomography (SPET or SPECT) with 99mTc-Exametazime. All patients suffered from unipolar depressive illness and were rated on the Newcastle scale and with the 17-item Hamilton scale. They completed tests of orientation and verbal memory on the day of ECT. For comparison, verbal memory was also tested on the preceding day. The uptake of 99mTc-Exametazime was expressed relative to calcarine/occipital cortex. Significant decreases in tracer uptake were confined to the inferior anterior cingulate cortex. The changes were correlated with the severity of depressive symptoms and more weakly with decrements of memory function produced by ECT; there was no significant correlation with stimulus intensity or electroencephalographic measures of seizure duration.
authors.affiliation: MRC Brain Metabolism Unit, Royal Edinburgh Hospital, UK.
authors.forename: A I
authors.initials: AI
authors.lastname: Scott
authors.forename: N
authors.initials: N
authors.lastname: Dougall
authors.forename: M
authors.initials: M
authors.lastname: Ross
authors.forename: R E
authors.initials: RE
authors.lastname: O'Carroll
authors.forename: W
authors.initials: W
authors.lastname: Riddle
authors.forename: K P
authors.initials: KP
authors.lastname: Ebmeier
authors.forename: G M
authors.initials: GM
authors.lastname: Goodwin
mesh_terms: D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D003866:Depressive Disorder / Q000000981:diagnostic imaging* / Q000628:therapy; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010091:Oximes / Q000493:pharmacokinetics*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime