Effects of pentachlorophenol (PCP) on the pituitary and thyroidal hormone regulation in the rat.
Investigations on rats after repeated application of pentachlorophenol (PCP) should clarify whether thyroid side effects caused by this xenobiotic can be seen in a dose range which does not cause major toxic effects. Female rats of the Wistar strain were treated with 3 and 30 mg PCP/kg body wt. daily by gavage for 28 days. To assess the potential impact of impurities the study was performed both with pure and technical grade PCP at the dosage of 3 mg.kg-1.day-1, and at a level of 30 mg.kg-1.day-1 with pure PCP only. The effects in animals on normal iodine diet were compared to those in animals on a low iodine diet. No decrease of body wt. was noticed, only the liver weights were increased slightly in animals treated with 30 mg.kg-1.day-1 PCP. However distinct effects on thyroid hormones as well as on thyrotropin (TSH) were observed: a pronounced fall of circulating thyroxine (T4) and triiodothyronine (T3) levels was accompanied by lower levels of both free thyroid hormones and TSH, and the T4:T3 ratio was decreased in serum. Furthermore the intrathyroidal hormone stores were reduced. An interference of PCP at pituitary or hypothalamic level is assumed as a major mode of action. Additional effects of the test substance on peripheral conversion can be suspected.
Jekat
F W
FW
Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität Münster, Germany.
Meisel
M L
ML
Eckard
R
R
Winterhoff
H
H
D000284:Administration, Oral; D000818:Animals; D004032:Diet; D004334:Drug Administration Schedule; D005260:Female; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010416:Pentachlorophenol / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D010416:Pentachlorophenol; D013974:Thyroxine