title: Chemotactic heterogeneity of eosinophils in Kimura's disease.
abstract: We evaluated the chemotactic heterogeneity of eosinophils in Kimura's disease. Patients with Kimura's disease were divided into two groups according to their clinical findings: one group had no other symptoms (KD), and another was accompanied with atopic dermatitis (KD + AD). The chemotactic response of eosinophils from two groups to 5 eosinophil chemotactic factors (ECF) derived from STO-2, an established T cell line. Eosinophils from KD were attracted only by ECF-PI5 and PI6 but not by ECF-PI7, PI8 and PI9. On the other hand, eosinophils from KD + AD responded to all 5 ECF. Eosinophils were further fractionated into normodense and hypodense eosinophils, and assessed for their chemotactic response. We thus found that there was little essential difference in their chemotactic responses to STO-2-derived ECF except ECF-PI9, though random migration of hypodense eosinophils was enhanced. The hypothesis that hypodense eosinophils are in the activated form was not always true, especially in the chemotactic response to ECF.
authors.affiliation: Department of Internal Medicine, Kumamoto University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Saita
authors.forename: M
authors.initials: M
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Hirashima
mesh_terms: D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000097:blood* / Q000150:complications; D002631:Chemotactic Factors, Eosinophil / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D003876:Dermatitis, Atopic / Q000097:blood / Q000150:complications; D004804:Eosinophils / Q000473:pathology* / Q000502:physiology*; D006801:Humans
chemical_list: D002631:Chemotactic Factors, Eosinophil