Cefminox: correlation between in-vitro susceptibility and pharmacokinetics and serum bactericidal activity in healthy volunteers.
Plasma concentration of cefminox and serum bactericidal activity against four ATCC strains (Escherichia coli 25992, Klebsiella pneumoniae 13833, Serratia marcescens 8100 and Bacteroides fragilis 25285), were determined over a 24 h period after administration of cefminox 1 and 2 g to six healthy volunteers in a randomized, cross-over, single blind study. The increase observed in the area under the bactericidal curve (AUBC) with the 2 g dose was at least 3.5 times that seen with the 1 g dose for all four test strains and was larger than predicted by the corresponding increase (1.84 times) in the area under the serum concentration versus time curve (AUC); a correlation (r = 0.88, P = 0.0001) between the cefminox concentration and the serum bactericidal titres was, however, observed with all four strains tested. The MBC6h showed a better association with the serum bactericidal titre (P < 0.01) than did the MIC or MBC.
Aguilar
L
L
Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.
Esteban
C
C
Frias
J
J
Pérez-Balcabao
I
I
Carcas
A J
AJ
Dal-Ré
R
R
D000328:Adult; D001419:Bacteria / Q000187:drug effects*; D001681:Biological Assay; D002513:Cephamycins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015610:Serum Bactericidal Test; D016037:Single-Blind Method
D002513:Cephamycins; C046079:cefminox