Potential species dependency for the pulmonary antiallergic effects of aerosolized heparin.
The inhibition of antigen aerosol-induced bronchoconstriction by heparin aerosol pretreatment has been demonstrated in conscious sheep. Therefore, we investigated the effect of heparin aerosol pretreatment on antigen aerosol-induced bronchoconstriction in anaesthetized and ventilated guinea-pigs. In one study all animals were pretreated with propranolol and indomethacin in order to produce a large bronchoconstriction, whereas in a second study this pretreatment was omitted in order to produce a smaller bronchoconstriction. In both studies aerosolized heparin failed to inhibit antigen aerosol-induced bronchoconstriction, whether delivered at 1, 10 and 100 mg/ml 10 min prior to antigen challenge or delivered at 50 mg/ml 60 min prior to antigen challenge. In contrast, salbutamol aerosol pretreatment (1 mg/ml, delivered 10 min prior to antigen challenge) produced a near-maximum inhibition of antigen aerosol-induced bronchoconstriction. These results suggest that the pulmonary antiallergic effects of aerosolized heparin are potentially species dependent.
Howell
R E
RE
Inflammation/Bone Metabolism Division, Wyeth Ayerst Research, Princeton, New Jersey 08543.
Woeppel
S L
SL
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D000941:Antigens; D001249:Asthma / Q000517:prevention & control; D016084:Bronchoconstriction / Q000187:drug effects*; D006168:Guinea Pigs; D006493:Heparin / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D012130:Respiratory Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D013045:Species Specificity
D000336:Aerosols; D000941:Antigens; D006493:Heparin; D011433:Propranolol; D007213:Indomethacin