Role of the beta-amyloid precursor protein in Alzheimer's disease.
Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the beta-amyloid precursor protein (APP), which gives rise to beta-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease--a prerequisite for rational drug development.
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110.
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D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D017354:Point Mutation; D011499:Protein Processing, Post-Translational
D016564:Amyloid beta-Protein Precursor