Anaplerotic effect of propionyl carnitine in rat heart mitochondria.
Carnitine and propionyl carnitine both increase production of 14CO2 from [1-14C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and 14CO2 evolution from [2-14C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.
Tassani
V
V
Dept. of Biological Chemistry, University of Padova, Italy.
Cattapan
F
F
Magnanimi
L
L
Peschechera
A
A
D000108:Acetylcarnitine / Q000378:metabolism; D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008314:Malonates / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D002316:Cardiotonic Agents; D008314:Malonates; D011773:Pyruvates; D002245:Carbon Dioxide; C003223:propionylcarnitine; D000108:Acetylcarnitine; C030290:malonic acid; D002331:Carnitine