title: Effect of meal frequency on serum amino acids and creatinine clearance in young men.
abstract: Seven healthy men consumed a liquid formula diet either as 3 meals taken at 0, 4, and 8 hours, or as 72 equal portions taken at 10-minute intervals (sipping). Day-long mean serum amino acids were similar on both treatments. Sipping reduced the fall in serum creatinine levels by more than 50% (p < 0.01), and reduced urine creatinine output and creatinine clearance by 11% (p < 0.05). These results suggest that increased meal frequency warrants investigation as a potentially beneficial maneuver in the dietary management of chronic renal failure.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.
authors.forename: T M
authors.initials: TM
authors.lastname: Wolever
mesh_terms: D000328:Adult; D000409:Alanine / Q000097:blood; D000596:Amino Acids / Q000097:blood*; D001120:Arginine / Q000097:blood; D003404:Creatinine / Q000097:blood* / Q000652:urine; D004435:Eating; D006801:Humans; D008239:Lysine / Q000097:blood; D008297:Male; D012016:Reference Values; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D000596:Amino Acids; D014508:Urea; D001120:Arginine; D003404:Creatinine; D008239:Lysine; D000409:Alanine