In vitro antifungal activity of triterpenoid saponins.
The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. alpha-Hederin was the most active compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.
Favel
A
A
Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille, France.
Steinmetz
M D
MD
Regli
P
P
Vidal-Ollivier
E
E
Elias
R
R
Balansard
G
G
D000935:Antifungal Agents / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D010944:Plants / Q000737:chemistry; D012503:Saponins / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
D000935:Antifungal Agents; D012503:Saponins; D014315:Triterpenes