[Experimental epidural and conduction anesthesia with azacaine].
Experimental studies were undertaken to examine azacaine used in mice during conduction anesthesia and in rabbits during epidural anesthesia in 0.75, 2 and 0.75, 1% solutions, respectively. It was found that azacaine in the above doses is 1.5-3.5-fold superior to 2% solutions of lidocaine (xycaine) and trimecaine (mesocaine) in their effect duration. Histological studies of the rabbit spinal cord after epidural azacaine administration revealed no significant changes in brain tissues.
Cherniakova
I V
IV
Zhukov
V N
VN
Osipov
S A
SA
Shadiev
A Sh
ASh
Skovpen'
T V
TV
D000765:Anesthesia, Conduction; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008012:Lidocaine; D008297:Male; D051379:Mice; D010875:Pipecolic Acids; D011817:Rabbits; D014288:Trimecaine
D000779:Anesthetics, Local; D010875:Pipecolic Acids; C069706:azacaine; D008012:Lidocaine; D014288:Trimecaine
Epidural'naia i provodnikovaia anesteziia azakainom v éksperimente.