title: Carcinosarcoma of urinary bladder: report of 5 cases with immunohistologic study.
abstract: We studied 5 cases of carcinosarcoma of the urinary bladder. Immunoperoxidase studies were performed to identify the nature of the tumor and to establish the diagnosis. We suggest that these tumors represent a transition of epithelial to mesenchymal malignancy. Three of our patients had a history of radiation therapy prior to development of carcinosarcoma; of which 2 had a long interval between exposure to radiation and tumor development. Radiation is a risk factor for endometrial carcinosarcoma, and in this report we strongly suggest such an association for the urinary bladder.
authors.affiliation: Department of Pathology, Monmouth Medical Center, Long Branch, New Jersey.
authors.forename: C
authors.initials: C
authors.lastname: Lahoti
authors.forename: R
authors.initials: R
authors.lastname: Schinella
authors.forename: A F
authors.initials: AF
authors.lastname: Rangwala
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Mizrachi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002296:Carcinosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology*