[Antibiotic activities of cefpirome against fresh clinical isolates resistant to multiple drugs].
Using multiple drug-resistant clinical isolates isolated since September 1992, minimum inhibitory concentrations (MICs) of cefpirome (CPR) were determined. Several control drugs were also used, and these MIC-determinations were made to determine the antibiotic activity of CPR. The obtained results are summarized as follows: 1. Antibiotic activities of CPR against methicillin-resistant Staphylococcus spp., Enterococcus faecalis, and benzylpenicillin-insensitive or resistant Streptococcus pneumoniae showed that expanded antibacterial spectrum of CPR and its enhanced antibiotic action against Gram-positive bacteria. We suggest that among the existing fourth-generation cephem antibiotics, CPR is "characteristically strong against Gram-positive bacteria". 2. Strong antibiotic activities of CPR were recognized against bacteria of family Enterobacteriaceae that were resistant to the third-generation cephems. The strong antibiotic activities appeared to be due to CPR's stability and decreased affinity for beta-lactamase. 3. Antibacterial spectrum of CPR was expanded against non-glucose fermented Gram-negative bacilli including Pseudomonas aeruginosa. It appears that this expansion of antibacterial spectrum is due to CPR's affinities for a wide range of penicillin-binding proteins as well as its improved permeability into tissues.
Deguchi
K
K
Section of Studies, Tokyo Clinical Research Center.
Yokota
N
N
Koguchi
M
M
Suzuki
Y
Y
Fukayama
S
S
Ishihara
R
R
Oda
S
S
Tanaka
S
S
Nakane
Y
Y
Fukumoto
T
T
D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016106:Methicillin Resistance; D010403:Penicillin Resistance; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D001618:beta-Lactamases / Q000494:pharmacology; D000097572:Cefpirome
D002511:Cephalosporins; D001618:beta-Lactamases; D000097572:Cefpirome