Congenital syphilitic nephrosis.
Analysis of congenital syphilis in 455 infants and neonates between 1977-1991 in Children's Hospital, Bangkok, Thailand revealed 11 cases (2.4%) with evidence of congenital syphilitic nephrotic syndrome which were confirmed by clinical, serologic and laboratory findings, long bone x-rays and renal biopsy. Ages of all 11 cases were between 1 day to 2 months (mean 24 days); 6 were boys and 5 girls. Two of them died because of necrotizing enterocolitis and sepsis respectively; the mortality rate was 18%. The other nine had complete recovery following penicillin therapy.
Niemsiri
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Renal Unit, Children's Hospital, Bangkok, Thailand.
D016470:Bacteremia / Q000209:etiology; D002423:Cause of Death; D003937:Diagnosis, Differential; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009401:Nephrosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D010406:Penicillins / Q000627:therapeutic use; D011159:Population Surveillance; D013590:Syphilis, Congenital / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D013785:Thailand / Q000453:epidemiology; D016896:Treatment Outcome; D014210:Treponema pallidum
D010406:Penicillins