Concurrent agranulocytosis and hepatitis secondary to clomipramine therapy.
A 67-year-old man developed concurrent severe agranulocytosis and elevation of hepatic transaminases as a result of treatment with clomipramine. Although such adverse drug reactions can be considered rare events, the potentially serious nature of these reactions vindicate the routine monitoring of blood picture, and liver function tests, after initiation of treatment with tricyclic antidepressants.
Alderman
C P
CP
Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia.
Atchison
M M
MM
McNeece
J I
JI
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000175:diagnosis; D002997:Clomipramine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D000637:Transaminases / Q000378:metabolism
D000637:Transaminases; D002997:Clomipramine