[Alpha 1-adrenoceptor involved in the process of VSMp control of renal sympathetic nerve activities in spinal cord in rats].
Experiment were performed on 40 urethane anesthetized Wistar rats. After preinjection of 6-hydroxydopamine (6-OHDA) into subarachnoid cavity at inferior thoracic part. Enhancement of renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) induced by electrical stimulation of pressor area of ventral surface of medulla (VSMp) were attenuated; but intrathecal phenylephrine had no effects. The results suggest that the alpha 1-adrenoceptors mediating descending excitatory effects of VSMp are located postsynaptically on the sympathetic preganglionic neurons.
Lin
M J
MJ
Department of Physiology, Fujian Medical College, Fuzhou.
Jia
B J
BJ
D000818:Animals; D004594:Electrophysiology; D007278:Injections, Spinal; D007668:Kidney / Q000294:innervation*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D016627:Oxidopamine