The effects of oxygenated free radicals on VEP spectral components in experimental diabetes.
In this experimental research, 33 Swiss albino rats were studied. They were divided into three equal groups as control, alloxan-diabetic (diabetic group) and alloxan-diabetic rats treated with ginkgo biloba extract (diabetic-GbE group). After two months of diabetes and before ophthalmoscopically visible diabetic retinopathy, flash VEPs of three groups were recorded and spectral analysis of VEPs was computed by Fast Fourier Transform (FFT) algorithm. Comparing the results of diabetic and diabetic-GbE groups with control group, we observed a significant increase in the amplitude (dB) of 5 Hz frequency for the left and right responses of rats. At some frequencies, we also found important differences between diabetic-GbE and control groups.
Apaydin
K C
KC
Department of Ophthalmology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Ağar
A
A
Yargiçoğlu
P
P
Oğuz
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D004569:Electroencephalography / Q000706:statistics & numerical data*; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology*; D005583:Fourier Analysis; D005609:Free Radicals / Q000009:adverse effects; D007839:Functional Laterality / Q000502:physiology; D020441:Ginkgo biloba; D008433:Mathematics; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D014795:Visual Pathways / Q000502:physiology / Q000503:physiopathology; D000096983:Ginkgo Extract
D001786:Blood Glucose; D005609:Free Radicals; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract