title: Bedside assessment of skin-fold thickness. A useful measurement for distinguishing Cushing's disease from other causes of hirsutism and oligomenorrhea.
abstract: BACKGROUND
  The known catabolic effects of glucocorticoid excess on protein metabolism prompted us to devise a method to assess this measure in reproductive-aged females with Cushing's disease. Since collagen protein is a major component of skin, decreased abundance of this protein should cause a reduction in skin-fold thickness. To determine whether skin-fold thickness is useful as an added tool in the diagnosis of Cushing's disease, we compared this value in female patients with Cushing's disease with those who presented with a similar set of symptoms.
  
  
  METHODS
  This open prospective study was conducted in an endocrinology clinic at a tertiary care center. The study population consisted of 88 females in the reproductive age group who presented to the clinic with hirsutism, oligomenorrhea, and/or obesity. Measurement of skin-fold thickness, body mass index, Ferriman-Gallwey index, and serum testosterone were performed in all patients.
  
  
  RESULTS
  Skin-fold thickness in the patients with Cushing's disease was 1.5 +/- 0.2 mm (range, 1.0 to 1.8 mm). This value was significantly (P < .01) lower than that in controls or subjects with other disorders that have a similar set of presenting symptoms.
  
  
  CONCLUSIONS
  Bedside assessment of skin-fold thickness is an easy, low-cost, and noninvasive test for distinguishing Cushing's disease from disorders with similar presenting symptoms in females of reproductive age. Assessment of skin-fold thickness should be used as an adjunct to current physical and biochemical study of patients with symptoms suggestive of Cushing's disease.
authors.affiliation: Department of Medicine, University of Calgary, Alberta.
authors.forename: B
authors.initials: B
authors.lastname: Corenblum
authors.forename: T
authors.initials: T
authors.lastname: Kwan
authors.forename: S
authors.initials: S
authors.lastname: Gee
authors.forename: N C
authors.initials: NC
authors.lastname: Wong
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003480:Cushing Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000209:etiology; D009839:Oligomenorrhea / Q000097:blood / Q000209:etiology*; D011446:Prospective Studies; D012885:Skinfold Thickness; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone