Carcinosarcoma of urinary bladder: report of 5 cases with immunohistologic study.
We studied 5 cases of carcinosarcoma of the urinary bladder. Immunoperoxidase studies were performed to identify the nature of the tumor and to establish the diagnosis. We suggest that these tumors represent a transition of epithelial to mesenchymal malignancy. Three of our patients had a history of radiation therapy prior to development of carcinosarcoma; of which 2 had a long interval between exposure to radiation and tumor development. Radiation is a risk factor for endometrial carcinosarcoma, and in this report we strongly suggest such an association for the urinary bladder.
Lahoti
C
C
Department of Pathology, Monmouth Medical Center, Long Branch, New Jersey.
Schinella
R
R
Rangwala
A F
AF
Lee
M
M
Mizrachi
H
H
D000368:Aged; D000369:Aged, 80 and over; D002296:Carcinosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology*