title: [Radiation and apoptosis].
abstract: Apoptosis is a kind of programmed cell death, that is, intrinsically programmed "cell suicide process". Mammalian thymic lymphocytes, thymocytes, show a typical apoptosis immediately after a low dose irradiation. Apoptosis appears also during radiotherapy of tumor, especially of thymoma. Tumor suppressor gene such as p53 and oncogene such as bcl-2 are found to be closely related to apoptotic processes in a cell. Possible mechanisms underlying interrelationship between expression of these genes, apoptosis and carcinogenesis were discussed.
authors.affiliation: Dept. of Biology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Ohyama
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects*; D002455:Cell Division; D016158:Genes, p53; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects; D009857:Oncogenes; D013945:Thymoma / Q000532:radiotherapy; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects; D013953:Thymus Neoplasms / Q000532:radiotherapy