Negative dose-response relationship for radiation-induced micronuclei in polychromatic erythrocytes of mice.
Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X-rays and at 6-hr intervals from 12-60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared much later following 6 Gy than after 2 Gy exposures, implicating cell cycle delay as the cause of the negative dose-response relationship.
McFee
A F
AF
Oak Ridge Institute for Science and Education, Medical Sciences Division, TN 37831-0117.
Cook
S B
SB
Abbott
M G
MG
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000528:radiation effects*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests