[Acquired factor VIII inhibitor in a patient with rheumatoid arthritis].
In the present report we describe a 66 year-old-woman, diagnosed of rheumatoid arthritis, who suffered a severe haemorrhagic syndrome caused by the presence of a circulating inhibitor to factor VIII. Inhibitor quantitation was measured with Bethesda test. After treatment with corticosteroids and high-dose immunoglobulin, a good clinical response was obtained; factor VIII:C activity increased with the disappearance of detectable inhibitor. This response was observed more effectively and rapidly than with prednisone treatment alone.
Ruiz-Calderón
A J
AJ
Servicio de Hematología, Hospital Universitario Virgen Macarena, Sevilla.
Carrasco
F
F
Duro
R
R
Constantino
M
M
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology* / Q000628:therapy; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006406:Hematoma / Q000209:etiology; D006474:Hemorrhagic Disorders / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D005169:Factor VIII; D011241:Prednisone
Inhibidor adquirido del factor VIII en una paciente con artritis reumatoide.