title: Inhibitory action of palmitic acid on the growth of Saccharomyces cerevisiae.
abstract: High concentrations of long-chain fatty acids have been found to be harmful to mammalian cells and prokaryotic organisms. This effect was investigated in Saccharomyces cerevisiae. Addition of 3 mmol/L palmitate to a yeast extract-peptone medium caused a significant inhibition of cell growth during the first 2 d of incubation, followed by renewed growth and palmitate utilization. Inhibition was also observed with palmitate concentrations down to 0.1 mmol/L. As inferred from catalase activity determinations, this effect was found to correlate with the absence of peroxisome proliferation. Finally, no inhibition was observed in exponential-phase cultures or in the presence of 0.1 g/L glucose, this suggesting that the physiological state of the cell may determine whether its growth will be inhibited by fatty acids.
authors.affiliation: Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
authors.forename: E C
authors.initials: EC
authors.lastname: Dell'Angelica
authors.forename: C A
authors.initials: CA
authors.lastname: Stella
authors.forename: M R
authors.initials: MR
authors.lastname: Ermácora
authors.forename: J A
authors.initials: JA
authors.lastname: Santomé
authors.forename: E H
authors.initials: EH
authors.lastname: Ramos
mesh_terms: D002374:Catalase / Q000378:metabolism; D003470:Culture Media; D005227:Fatty Acids / Q000378:metabolism; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism
chemical_list: D003470:Culture Media; D005227:Fatty Acids; D010169:Palmitic Acids; D019308:Palmitic Acid; D002374:Catalase