[Estrogens, progestins and cancer of the endometrium].
The presence of estrogens alone increases the risk of cancer of the endometrium. The risk increases with dosage and length of administration. Estrogens have a promoting rather than an initiating role since the risk progressively disappears after stopping treatment. Hormone-induced cancers have a better prognosis than spontaneous cancers. The association of progesterone or a progestogen obviates this risk. Prescription of oestrogens after treatment of cancer of the endometrium is non longer strictly contraindicated. Each case should be considered independently.
Laffargue
F
F
Service de gynécologie obstétrique, hôpital Arnaud-de-Villeneuve, Montpellier.
Daures
J P
JP
D000328:Adult; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects; D011372:Progestins / Q000627:therapeutic use*; D012307:Risk Factors
D011372:Progestins
Oestrogènes, progestatifs et cancer de l'endomètre.