title: Effects of intravenous verapamil on atrial vulnerability.
abstract: To investigate the effects of verapamil on indicators of atrial vulnerability, we examined 30 patients with paroxysmal supraventricular tachycardia who received intravenous verapamil during an electrophysiologic study. Single atrial extrastimuli were given before and after intravenous administration of verapamil to induce repetitive atrial firing (RAF) or atrial fibrillation, and to examine the maximum A2/A1, which was defined as the maximum ratio of the duration of the atrial electrogram resulting from premature stimulation (A2) to that resulting from the basic drive beat (A1). The maximum A2/A1 increased from 145 +/- 20% to 154 +/- 25% (p < 0.02) after verapamil administration. The maximum A2/A1 in patients in whom neither RAF nor atrial fibrillation were induced both before and after verapamil were smaller than those in patients in whom RAF was induced only after verapamil (before; 138 +/- 20% vs 165 +/- 15%, p < 0.02. after; 144 +/- 22% vs 172 +/- 17%, p < 0.05). RAF or atrial fibrillation was induced only after verapamil in 6 patients, who showed a maximum A2/A1 before verapamil of 150% or more. These data suggest that verapamil may induce repetitive atrial firing and possibly atrial fibrillation in some predisposed patients, especially in those that have a greater maximum A2/A1, which may be an indicator of local intraatrial conduction delay before drug infusion.
authors.affiliation: Third Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Isomoto
authors.forename: A
authors.initials: A
authors.lastname: Shimizu
authors.forename: A
authors.initials: A
authors.lastname: Konoe
authors.forename: M
authors.initials: M
authors.lastname: Tanigawa
authors.forename: M
authors.initials: M
authors.lastname: Kaibara
authors.forename: O A
authors.initials: OA
authors.lastname: Centurion
authors.forename: M
authors.initials: M
authors.lastname: Fukatani
authors.forename: K
authors.initials: K
authors.lastname: Yano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000139:chemically induced; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000187:drug effects* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012032:Refractory Period, Electrophysiological; D013614:Tachycardia, Paroxysmal / Q000503:physiopathology; D013617:Tachycardia, Supraventricular / Q000503:physiopathology; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil