Protein intake and glomerular hyperfiltration in insulin--treated diabetics without manifest nephropathy.
Protein intake in relation to glomerular filtration rate (GFR) and urinary albumin excretion (UAE) has been studied in 96 insulin-treated diabetic patients, 20-40 years of age and without nephropathy. They had diastolic blood pressure (DBP) not exceeding 90 mmHg and a GFR exceeding -2 SD of the age-related value. They were without medications except for insulin. There were no significant differences in protein intake between diabetic patients with and without hyperfiltration (1.18 +/- 0.26 g/kg/d vs 1.21 +/- 0.42 g/kg/d, p = 0.75) or between diabetic patients with or without increased UAE (1.16 +/- 0.41 g/kg/d vs 1.24 +/- 0.37 g/kg/d, p = 0.37). No relations were found between protein intake and GFR or UAE in the whole sample, but a positive relation was found between UAE and protein intake in patients with increased UAE. Protein intake correlated with UAE in hyperfiltrators who use tobacco (n = 8, r = 0.85, p = 0.01), but not in non-users (n = 11, r = 0.24, p = 0.48). In conclusion our findings give no support for a relation between high protein intake and glomerular hyperfiltration in insulin-treated-diabetic patients. However, in contrast to non-users of tobacco, a positive relation was found between UAE and protein intake in tobacco users with hyperfiltration.
Ekberg
G
G
Department of Medicine, Central Hospital, Växjö, Sweden.
Sjöfors
G
G
Grefberg
N
N
Larsson
L O
LO
Vaara
I
I
D000328:Adult; D000419:Albuminuria / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D003928:Diabetic Nephropathies; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D010947:Plants, Toxic; D012907:Smoking / Q000453:epidemiology; D014030:Tobacco, Smokeless
D004044:Dietary Proteins; D007328:Insulin