Toxic effect on human spermatozoa by Chlamydia trachomatis purified lipopolysaccharide.
We have investigated the effect that lipopolysaccharide extracted from Chlamydia trachomatis has on human spermatozoa. A lipopolysaccharide of 0.1 microgram ml-1 caused a spermatozoa mortality rate of 65 +/- 4% evaluated by eosin exclusion test. The toxic activity occurred rapidly even after brief incubation times, reaching the maximum (100% mortality) within 60 min.
Galdiero
F
F
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Italy.
Sommese
L
L
Gorga
F
F
Galdiero
E
E
Rizzo
A
A
Ajello
M
M
D016923:Cell Death; D002692:Chlamydia trachomatis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D007248:Infertility, Male / Q000209:etiology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D013094:Spermatozoa / Q000187:drug effects*
D008070:Lipopolysaccharides