[Comparison between large bowel cancer in young people and that in middle-aged and old-aged people].
In order to understand the difference in risk factors of large bowel cancer in different age groups, a population-based case-control study including two age groups, one group with the age of < or = 40 (180 cases and 184 controls). And the other group with the age of > 40 (1148 cases and 1161 controls), was conducted in Shanghai. The study indicated that: 1. The patients of age > 40 with large bowel cancer had closer relationship with the environmental factors (esp. dietary and nutritional factors) than the patients of age < or = 40. 2. The familial genetic risk factor which affected development of the cancer in younger group was two-fold higher than that in elder group. The results suggested that both genetic and environmental factors influenced the occurrence of the cancer, and the role of the genetic factor in < or = 40-yr group and that of the environmental factors in > 40-yr group appeared to be important.
Yang
G
G
Cancer Institute Zhejiang Medical University, Hangzhou.
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors