title: Procedure for reduction of test chemical requirement in preliminary assays using the L5178Y TK+/- mouse lymphoma forward mutation assay.
authors.affiliation: Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
authors.forename: J B
authors.initials: JB
authors.lastname: Majeska
authors.forename: H E
authors.initials: HE
authors.lastname: Holden
mesh_terms: D015073:2-Acetylaminofluorene / Q000031:analogs & derivatives / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D005449:Fluorenes / Q000633:toxicity; D008110:Liver Extracts; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice; D009152:Mutagenicity Tests; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D005449:Fluorenes; D008110:Liver Extracts; C019499:2-nitrofluorene; D000431:Ethanol; D008748:Methylcholanthrene; D005020:Ethyl Methanesulfonate; D015073:2-Acetylaminofluorene; C028676:4-acetylaminofluorene