title: Endometrial structure after superovulation: a prospective controlled study.
abstract: OBJECTIVE
  To demonstrate the effect of superovulation using a GnRH agonist (GnRH-a) and hMG and hCG on endometrial structure.
  
  
  METHODS
  Prospective, case-controlled study.
  
  
  METHODS
  Tertiary referral assisted reproduction unit in an academic department.
  
  
  METHODS
  Eleven women undergoing GIFT or IVF, without ET.
  
  
  METHODS
  All women were treated with a long stimulation regimen using the depot GnRH-a Goserelin (ICI, Macclesfield, United Kingdom) and hMG and hCG.
  
  
  METHODS
  Comparison of endometrial biopsy specimens taken 4 days after ovulation in an unstimulated cycle with specimens taken 4 days after oocyte recovery, using standard dating criteria and morphometric analysis.
  
  
  RESULTS
  There was no difference in endometrial glandular development as assessed by either standard criteria or morphometric analysis.
  
  
  CONCLUSIONS
  Superovulation preceded by pituitary down regulation is not associated with abnormal endometrial glandular development, even though supraphysiological levels of E2 and P are induced.
authors.affiliation: Department of Obstetrics and Gynecology, University of Manchester, United Kingdom.
authors.forename: P J
authors.initials: PJ
authors.lastname: Macrow
authors.forename: T C
authors.initials: TC
authors.lastname: Li
authors.forename: M W
authors.initials: MW
authors.lastname: Seif
authors.forename: C H
authors.initials: CH
authors.lastname: Buckley
authors.forename: M
authors.initials: M
authors.lastname: Elstein
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004717:Endometrium / Q000033:anatomy & histology* / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D013480:Superovulation
chemical_list: D006063:Chorionic Gonadotropin; D017273:Goserelin; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins