[Clinical study on transfer into lung tissue of cefminox].
Nineteen patients who underwent pulmonary resection due to lung diseases were administered with 2 g of cefminox (CMNX) by intravenous drip infusion just before surgery. CMNX levels in the serum and lung tissue were determined and pharmacokinetic parameters were derived. The obtained results are summarized as follows: 1. Pharmacokinetic parameter (K1/K2) derived from serum and lung tissue concentrations using deconvolution method was 0.46. 2. CMNX was useful for prophylaxis of postoperative infections with lung resection.
Funakoshi
N
N
Department of Cardiovascular and Thoracic Surgery, Tsuchiura Kyodo Hospital.
Fujiwara
A
A
Nagaoka
H
H
Murayama
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002513:Cephamycins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011292:Premedication
D002513:Cephamycins; C046079:cefminox