title: Effects of cessation of caffeinated-coffee consumption on ambulatory and resting blood pressure in men.
abstract: Coffee consumption has been weakly linked to high blood pressure (BP). The hypothesis that cessation of caffeinated-coffee consumption lowers ambulatory BP was tested in men in a randomized trial. One hundred eighty-six middle-aged, normotensive, male, habitual caffeinated-coffee consumers were recruited. Of these subjects, 150 had sufficiently complete, ambulatory BP measurements for analysis. After 2 months of standard caffeinated-coffee consumption, subjects were randomized to consume an equal amount of the same standard caffeinated coffee or a standard decaffeinated coffee, or to discontinue coffee consumption for 2 months. Diet composition, body weight and exercise did not change. Resting BP and heart rate were not different between the groups before and after intervention. In comparison with the continued caffeinated-coffee group (control), the decaffeinated-coffee group revealed significant reductions in mean ambulatory systolic BP during the morning (-4.0 +/- 11 mm Hg; p = 0.014), afternoon (-5.3 +/- 10 mm Hg; p = 0.001) and evening (-3.2 +/- 10 mm Hg; p = 0.003) hours, reductions in mean ambulatory diastolic BP during the afternoon (-1.8 +/- 10 mm Hg; p = 0.063) and evening (-1.8 +/- 10 mm Hg; p = 0.059) hours and no change in ambulatory heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Molecular and Nuclear Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley.
authors.forename: H R
authors.initials: HR
authors.lastname: Superko
authors.forename: J
authors.initials: J
authors.lastname: Myll
authors.forename: C
authors.initials: C
authors.lastname: DiRicco
authors.forename: P T
authors.initials: PT
authors.lastname: Williams
authors.forename: W M
authors.initials: WM
authors.lastname: Bortz
authors.forename: P D
authors.initials: PD
authors.lastname: Wood
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D002110:Caffeine / Q000494:pharmacology*; D002940:Circadian Rhythm; D003069:Coffee; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D003069:Coffee; D002110:Caffeine