Catecholamines in hypothalamus, ovaries and uteri of rats with precocious puberty.
The concentration of catecholamines in the hypothalamus and reproductive organs of rats with hypothalamic lesions placed on the day of birth was investigated. In an attempt to contribute to the discussion concerning the role of catecholamines in regulation of puberty, the aim of this study was to examine the content of hypothalamic, ovarian and uterine catecholamines in female rats with precocious vaginal opening. The animals were sacrificed on the day of precocious puberty, which occurred at the age of 25.71 +/- 0.98 days. The data obtained were compared with intact (pubertal) controls obtained on the day of vaginal opening (40.13 +/- 1.35 days) as well as in infantile intact controls of corresponding age of the lesioned animals. In the ovaries of both animals (i.e. lesioned and sacrificed on day of vaginal opening and the infantile controls of corresponding age), small and medium sized follicles were present. Ruptured follicles were evident only in the pubertal controls. The mass of ovaries and uteri from lesioned rats was also significantly lower than in the pubertal controls. Concentrations of norepinephrine in both ovaries and uteri on the day of vaginal opening of the animals with posterior hypothalamic lesions and of infantile controls, was significantly higher than in pubertal controls on the day of vaginal opening. Epinephrine was significantly higher in the uterine tissues of lesioned and infantile controls as compared to pubertal animals. The levels of dopamine and norepinephrine in the hypothalamus of lesioned and pubertal controls on the day of vaginal opening were significantly higher than in infantile controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Ivanisević-Milovanović
O K
OK
Laboratory for Molecular Biology and Endocrinology, Institute of Nuclear Sciences, Beograd, Yugoslavia.
Pantic
V
V
Demajo
M
M
Loncar-Stevanović
H
H
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000254:growth & development / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000502:physiology; D010053:Ovary / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation; D014599:Uterus / Q000254:growth & development / Q000378:metabolism*; D014621:Vagina / Q000254:growth & development / Q000502:physiology
D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine