[Determination of apparent pharmacokinetic parameters of shengfu injection by acute mortality of mice].
Apparent pharmacokinetic parameters of Shengfu injection, a first-aid traditional Chinese medicine, were determined by acute mortality of animals. The results suggested that the pharmacokinetics of Shengfu injection accords with the two compartment open model, and t1/2 alpha = 0.063h, t1/2 beta = 2.70h. The process of distribution was quite rapid, and the process of elimination was slow.
Gong
W
W
Zhang
Z
Z
Hou
S
S
Liao
G
G
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D005894:Panax; D010946:Plants, Medicinal
D004365:Drugs, Chinese Herbal