title: Quantitative in vivo iontophoretic studies.
abstract: An experimental methodology was developed to evaluate the physicochemical basis for in vitro-in vivo correlations in iontophoretic delivery situations. This experimental methodology can be used to quantitatively evaluate the extent of interaction between chemical permeation enhancers and iontophoresis for drug delivery. The inherent advantages of using Ag/AgCl electrodes are fully exploited to control pH and minimize depletion of permeant during prolonged periods of iontophoresis.
authors.affiliation: Department of Pharmaceutics, University of Utah, Salt Lake City 84112.
authors.forename: M H
authors.initials: MH
authors.lastname: Su
authors.forename: V
authors.initials: V
authors.lastname: Srinivasan
authors.forename: A H
authors.initials: AH
authors.lastname: Ghanem
authors.forename: W I
authors.initials: WI
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D006863:Hydrogen-Ion Concentration; D007478:Iontophoresis / Q000379:methods*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000378:metabolism*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000493:pharmacokinetics
chemical_list: D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium