Differential effect of xanthopterin and biopterin on cell growth.
1. Xanthopterin inhibited proliferation of primary renal proximal tubule cells (RPTC) and LLC-PK1 cells while in a growth phase but when incubated at confluence the cells were relatively insensitive. 2. The growth of malignant human prostate PC-3 cells was also inhibited by xanthopterin in a concentration and time dependent manner. 3. Dunning R3327 AT-3 rat prostate tumor cells which were exposed to xanthopterin in vitro before their in vivo inoculation resulted in smaller tumours while in vivo administration of xanthopterin following implantation also resulted in smaller tumors. 4. Xanthopterin exerts differential effects on cell growth dependent upon the cell origin and their state of proliferation.
Rubenstein
M
M
Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL 60612.
Muchnik
S
S
Garber
S L
SL
Arruda
J A
JA
Dunea
G
G
D000818:Animals; D001708:Biopterins / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology; D011817:Rabbits; D014407:Tumor Cells, Cultured; D014976:Xanthopterin / Q000494:pharmacology*
D001708:Biopterins; D014976:Xanthopterin