title: Polonium metabolism in adult female baboons.
abstract: The biokinetics of polonium in nonhuman primates (Papio anubis) has been studied after intravenous injection of 210Po citrate. The urinary excretion of polonium in the baboon could be described by a single exponential function with a half-time of 15.6 days. Excretion fractions of polonium were found to be markedly different from those reported for other species, including humans. Polonium-210 was found to be distributed throughout the soft tissues of the baboon with 29% of the injected polonium being deposited in liver, 7% in kidneys and 0.6% in spleen. Retention of polonium in all tissues exhibited single exponential functions; however, the biological half-times were variable, ranging from 15 to 50 days.
authors.affiliation: Malcolm Pirnie, Inc., Cranbury, New Jersey 08512-9543.
authors.forename: A
authors.initials: A
authors.lastname: Fellman
authors.forename: L
authors.initials: L
authors.lastname: Ralston
authors.forename: D
authors.initials: D
authors.lastname: Hickman
authors.forename: L
authors.initials: L
authors.lastname: Ayres
authors.forename: N
authors.initials: N
authors.lastname: Cohen
mesh_terms: D000818:Animals; D005243:Feces / Q000737:chemistry; D005260:Female; D010215:Papio; D011059:Polonium / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D011059:Polonium