Effects of washing with a neutralizing agent on alkaline skin injuries in an experimental model.
In this report a skin alkaline injury model was constructed using experimental rats and 2 N NaOH. We observed the effects of washing with a neutralizing agent on the subcutaneous tissue pH at 1, 10 and 30 min after injury and compared it with water-washing groups. In comparison with the water washing group, the peak pH values following the use of the neutralizing agent were significantly higher in the 1-min washing group, and significantly lower in the 10-min and 30-min washing groups. Changes in the pH values of the subcutaneous tissue after reaching a peak showed a similar course in the 1-min washing group, whereas in the 10 and 30 min washing groups there was a significantly different rate of decrease of pH. These results indicate that although treatment with a neutralizing agent directly after injury causes harmful effects due to the neutralizing reaction with a highly concentrated alkali. Subsequently with prolonged washing there is an effective reduction of the high pH.
Yano
K
K
Department of Plastic and Reconstructive Surgery, Kagawa Medical School, Japan.
Hata
Y
Y
Matsuka
K
K
Ito
O
O
Matsuda
H
H
D000818:Animals; D002057:Burns, Chemical / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006863:Hydrogen-Ion Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D012972:Sodium Hydroxide
D012972:Sodium Hydroxide