Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats.
Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), the positive control. Control activities in male rats exceeded those in females by about 2-3 fold.
Jordan
M C
MC
Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre Limited, Cambridgeshire, UK.
Waller
A R
AR
Chasseaud
L F
LF
Barbhaiya
R H
RH
D015660:7-Alkoxycoumarin O-Dealkylase / Q000378:metabolism*; D000284:Administration, Oral; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics
D002511:Cephalosporins; D000077723:Cefepime; D003577:Cytochrome P-450 Enzyme System; D015660:7-Alkoxycoumarin O-Dealkylase; D000633:Aminopyrine N-Demethylase