title: Pharmacokinetics of alkylating agents.
abstract: Alkylating agents have been used for over 30 years in the treatment of malignant disease. Because of their very reactive nature, studies of their intermediate metabolism have been difficult. However, this is now possible with modern analytical techniques. Further understanding of their metabolism and pharmacokinetics should lead to a more rational use in the clinic.
authors.affiliation: Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lind
authors.forename: C
authors.initials: C
authors.lastname: Ardiet
mesh_terms: D000477:Alkylating Agents / Q000493:pharmacokinetics*; D002330:Carmustine / Q000493:pharmacokinetics; D002699:Chlorambucil / Q000493:pharmacokinetics; D003520:Cyclophosphamide / Q000493:pharmacokinetics; D006801:Humans; D007069:Ifosfamide / Q000493:pharmacokinetics; D008130:Lomustine / Q000493:pharmacokinetics; D008558:Melphalan / Q000493:pharmacokinetics; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009607:Nitrosourea Compounds / Q000493:pharmacokinetics; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics; D013852:Thiotepa / Q000493:pharmacokinetics
chemical_list: D000477:Alkylating Agents; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; D002699:Chlorambucil; D008130:Lomustine; D003520:Cyclophosphamide; D013852:Thiotepa; C054368:fotemustine; D008558:Melphalan; D002330:Carmustine; D007069:Ifosfamide