[Anti-gastric antibodies and gastritis in insulin-dependent diabetes in children].
BACKGROUND
Adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. Knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance.


METHODS
68 patients (29 boys and 39 girls), aged from 5 yr 2 mo to 19 yr 10 mo, and treated for insulin-dependent diabetes from 1 mo to 14 yr 6 mo, were included in the study. Fasting blood concentrations of gastrin (G), pepsinogen (PG1), anti-gastric parietal cell antibodies (PCA) were measured. Fiberoptic endoscopy and biopsy of the gastroduodenal mucosa were performed in PCA+ patients and biopsy samples were examined for Helicobacter pylori (HP).


RESULTS
12 patients were PCA+; 3 of them had blood gastrin levels above 104 pg/ml and 4 had blood pepsinogen levels 24 ng/ml. Histologically, 3 patients had chronic diffuse gastritis (2 were HP+); 2 had chronic gastritis restricted to the antro-pyloric area (both were HP+); 3 had follicular lymphoid hyperplasia (without HP) and 4 had normal mucosa (without HP).


CONCLUSIONS
The presence of PCA can predict the risk of chronic gastritis, possibly auto-immune in origin, in children with insulin-dependent diabetes.
de'Angelis
G L
GL
Service de Pédiatrie de l'Université de Parme, Italie.
Apollionio
G
G
Boselli
E
E
De Fanti
A
A
De Luca
F
F
Fulgido
S
S
Romanini
E
E
Vanelli
M
M
D000293:Adolescent; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000276:immunology; D005756:Gastritis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D010295:Parietal Cells, Gastric / Q000276:immunology*; D010435:Pepsinogens / Q000097:blood; D011237:Predictive Value of Tests
D000906:Antibodies; D010435:Pepsinogens
Anticorps antiestomac et gastrite au cours du diabète insulino-dépendant de l'enfant.