title: [Hypertension and well-being: a study with indapamide].
abstract: OBJECTIVE
  Evaluate the clinical efficacy and quality of life of indapamide in patients with mild and moderate arterial systemic hypertension under indapamide.
  
  
  METHODS
  Open prospective design.
  
  
  METHODS
  Outpatient clinics of the Instituto Nacional de Cardiologia Preventiva in Lisbon.
  
  
  METHODS
  Thirty-two patients whose supine diastolic blood pressure was between 95 ans 115 mmHg without known secondary hypertension, unstable diabetes, cardiac, renal or hepatic failure, hypokalemia, coronary artery disease or stroke in the previous year.
  
  
  METHODS
  After a two week wash-out and four week placebo periods, indapamide has been given in a single daily dose of 2.5 mg at breakfast during 12 weeks.
  
  
  RESULTS
  The mean systolic/diastolic blood pressures was reduced from 155.7/103.7 to 138.6/86.1 mmHg (p < 0.0001). The mean standing systolic/diastolic blood pressure lowered from 160.2/103.7 to 141.6/85.9 mmHg (p < 0.0001). The questionnaires on quality of life and the analogic visual scale showed a progressive and significant improvement in general well-being. In the patient questionnaire the percentage of improvement was 80% (16/20 items) namely asthenia, headache, attention, dizziness, tinnitus and visual disturbance. In the physician questionnaire all the items improved. Biochemical acceptability was characterized by the stability of sodium, chlorine, glucose, creatinine, urea, cholesterol, triglycerides, uric acid and slight decrease in potassium from 4.38 to 4.14 mmol/l (p < 0.01) ranging in normal values.
  
  
  CONCLUSIONS
  These results confirm the clinical efficacy of indapamide and its beneficial effects on quality of life in patients with mild and moderate hypertension when administered in monotherapy.
authors.affiliation: Instituto Nacional de Cardiologia Preventiva, Lisboa.
authors.forename: T
authors.initials: T
authors.lastname: Rodrigues
authors.forename: L
authors.initials: L
authors.lastname: Macieira
authors.forename: A
authors.initials: A
authors.lastname: Alfaiate
authors.forename: A
authors.initials: A
authors.lastname: Gouveia-Oliveira
authors.forename: F
authors.initials: F
authors.lastname: Matias
authors.forename: A
authors.initials: A
authors.lastname: Corrêa-Nunes
authors.forename: M O
authors.initials: MO
authors.lastname: Carrageta
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D007190:Indapamide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D007190:Indapamide
vernacular_title: Hipertensão e bem-estar: estudo com indapamida.