Platelets stored for 6 days in a polyolefin container in a synthetic medium with minimal plasma carry-over.
Platelet concentrates (PC) were stored for 6 days in either polyolefin (PO) or polyvinylchloride/di-(2-ethylhexyl)phtalate (PVC/DEHP) bags in 100% plasma or in a synthetic medium with 35 or 10% plasma. For all conditions studied the usual in vitro parameters were well maintained, with a pH above 6.8. In both bag types platelets can be satisfactorily stored for 6 days in a synthetic medium with minimal amounts of residual plasma. For this medium, the PO bag offers a slight advantage with respect to the preservation of platelet ATP content (> 80 versus > 70% in the PVC bags) and aggregation and adhesion capacity. The adhesion capacity increased in the PO bags, while it decreased in the PVC bags.
Boomgaard
M N
MN
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Gouwerok
C W
CW
de Korte
D
D
Loos
J A
JA
D000179:Acrylates; D000227:Adenine Nucleotides / Q000097:blood; D015703:Antigens, CD / Q000032:analysis; D016824:Antigens, Human Platelet / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D001793:Blood Preservation / Q000295:instrumentation*; D004051:Diethylhexyl Phthalate; D004734:Energy Metabolism; D006801:Humans; D010949:Plasma; D015539:Platelet Activation; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011090:Polyenes; D011095:Polyethylenes; D011126:Polypropylenes; D012996:Solutions; D013997:Time Factors; D014752:Vinyl Chloride
D000179:Acrylates; D000227:Adenine Nucleotides; D015703:Antigens, CD; D016824:Antigens, Human Platelet; D015415:Biomarkers; D011090:Polyenes; D011095:Polyethylenes; D011126:Polypropylenes; D012996:Solutions; C035051:PL 732; D004051:Diethylhexyl Phthalate; D014752:Vinyl Chloride