title: [Disorders of immune status in duodenal ulcer complicated by perforation and peritonitis].
abstract: The chemotaxic activity of neutrophil granulocytes was studied in 112 patients with duodenal ulcer disease complicated by perforation and peritonitis with a different degree of spreading. Sharp decrease in spontaneous migration of leukocytes (SML) was revealed in generalized peritonitis. In diffuse peritonitis, the index didn't differ from that in normal subjects. In patients with the complicated course of the postoperative period, SML stimulation under the influence of the own serum was noted. At day 3-9 after the operation, the stimulating activity of the humoral factors of immunity was gradually decreasing. Use of the stimulators of migrative activity of phagocytes contributes to normalization of their function. In patients who had the immunocorrigative agents been prescribed, aggravation of peritonitis and purulent-septic complications were noted 1.4-fold less often than in absence of such treatment.
authors.forename: V I
authors.initials: VI
authors.lastname: Bondarev
authors.forename: V T
authors.initials: VT
authors.lastname: Radomskiĭ
authors.forename: N P
authors.initials: NP
authors.lastname: Ablitsov
authors.forename: A P
authors.initials: AP
authors.lastname: Baziak
authors.forename: I M
authors.initials: IM
authors.lastname: Iakovleva
authors.forename: A K
authors.initials: AK
authors.lastname: Kiandarian
mesh_terms: D000328:Adult; D002464:Cell Migration Inhibition; D004381:Duodenal Ulcer / Q000150:complications / Q000276:immunology* / Q000601:surgery; D005743:Gastrectomy; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D010439:Peptic Ulcer Perforation / Q000150:complications / Q000276:immunology* / Q000601:surgery; D010538:Peritonitis / Q000150:complications / Q000276:immunology* / Q000601:surgery; D010586:Phagocytes / Q000276:immunology*; D011184:Postoperative Period; D014629:Vagotomy, Proximal Gastric
vernacular_title: Narushenie immunnogo statusa pri iazvennoĭ bolezni dvenadtsatiperstnoĭ kishki, oslozhnënnoĭ perforatsieĭ i peritonitom.