Acoustic rhinometry compared with posterior rhinomanometry in the measurement of histamine- and bradykinin-induced changes in nasal airway patency.
1. Acoustic rhinometry is a relatively new method for objectively assessing nasal airway patency. In this paper we compare acoustic rhinometry with active posterior rhinomanometry. 2. Twenty normal healthy volunteers underwent nasal challenge with either histamine or bradykinin, 100 micrograms to 1000 micrograms, and responses were assessed by acoustic rhinometry. A further 20 subjects received identical nasal challenges and responses were assessed by active posterior rhinomanometry. 3. On a subsequent occasion, the subjects challenged previously with histamine, were given the selective H1-receptor antagonist, cetirizine, 10 mg orally, 3 h before repeat nasal challenge with histamine, 100-1000 micrograms. Again, responses were assessed by active posterior rhinomanometry and acoustic rhinometry. 4. The acoustic reflection measurements and the nasal airway resistance measurements showed comparable, significant dose-related changes in nasal patency to both histamine and bradykinin. Pretreatment with cetirizine blocked the histamine-induced change in nasal patency as measured by both methods. 5. We conclude that acoustic rhinometry has a number of advantages over posterior rhinomanometry. It is quick to perform, requires minimal subject co-operation and gives a reliable objective, measurement of dose-related changes in nasal airway patency before and after pharmacological treatment.
Austin
C E
CE
Department of Pharmacology, University College London.
Foreman
J C
JC
D000162:Acoustics; D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology*; D017332:Cetirizine / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008365:Manometry; D009296:Nasal Cavity / Q000502:physiology*; D015508:Nasal Obstruction / Q000139:chemically induced*; D012123:Pulmonary Ventilation / Q000187:drug effects; D012129:Respiratory Function Tests / Q000295:instrumentation / Q000379:methods*
D006632:Histamine; D001920:Bradykinin; D017332:Cetirizine