[The embryotoxic effect in rats exposed to the blood serum of newborn infants tested for the presence of transfer factors].
Pregnant rats (day 14 of gestation) received intraamniotic injections of newborn human serum. Transfer factors (TF) present in injected serum produced significant embryotoxic and teratogenic effects, as well as changes in coordination of motor activity (EMG) in newborn rats. The extent of embryological disturbances and the motor activity of 33- to 34-day old recipient rats depend on TF concentration (at serum dilution 1:2) and on the state of infant's motor functions ("normal" group and "risk" group). The results obtained allow to objectively determine the pathogenic effect of serum TF on embryotoxicity and formation of motor coordination in the donor infant.
Abdaladze
N S
NS
Avaliani
T V
TV
Chebotar'
N A
NA
Ataeva
O V
OV
Bogdanov
O V
OV
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000650:Amnion; D000818:Animals; D000831:Animals, Newborn; D004576:Electromyography / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007267:Injections; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D014165:Transfer Factor / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity*
D014165:Transfer Factor
Embriotoksicheskiĭ éffekt u krys pri vozdeĭstvii syvorotkoĭ krovi novorozhdennykh deteĭ, testiruemykh na nalichie transfernykh faktorov.