Disease recurrence after orthotopic liver transplantation.
With the advent of cyclosporine immunosuppression in the late 1970s, liver transplantation became a widespread modality for the treatment of end-stage liver disease. Several metabolic disorders that produce liver injury, such as Wilson's disease and alpha-1-antitrypsin deficiency, are cured by liver transplantation. However, many other diseases for which transplantation is undertaken may recur in the allograft. As follow-up increases and newer diagnostic modalities become available, those diseases that recur, and their natural histories, are becoming better understood. This new information may lead to a reevaluation of the suitability of some conditions for transplantation. This article briefly reviews disease recurrence in orthotopic liver transplants.
Cummings
O W
OW
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis.
D001660:Biliary Tract Diseases / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000473:pathology; D016031:Liver Transplantation / Q000473:pathology*; D012008:Recurrence