Synchronism of pressor response and grooming behavior in freely moving, conscious rats following intracerebroventricular administration of ACTH/MSH-like peptides.
After the i.c.v. administration of 300 pmol ACTH-(1-24) or [Nle4,D-Phe7]alpha-MSH, a long-lasting increase in blood pressure was observed synchronously with the incidence of excessive grooming. Two structurally related peptides with no grooming behavior-inducing potency, ACTH-(7-16)-NH2 and gamma 2-MSH, in doses of 300 and 500 pmol, respectively, caused a slight and short-lasting increase in blood pressure or had no effect, respectively. When the grooming behavior-inducing effect of ACTH-(1-24) was abolished, either by the prior manipulation of central dopaminergic neurotransmission by the i.c.v. administration of the dopamine receptor antagonist, haloperidol, or, due to the occurrence of single-dose tolerance to ACTH-(1-24), the pressor response was abolished as well. These data are in support of the postulate that the incidence of grooming behavior and the elevation of blood pressure are temporally associated and indicate that the two phenomena are causally related.
Versteeg
D H
DH
Department of Pharmacology, Rudolf Magnus Institute, Medical Faculty, Utrecht University, The Netherlands.
Florijn
W J
WJ
Holtmaat
A J
AJ
Gispen
W H
WH
De Wildt
D J
DJ
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003366:Cosyntropin / Q000008:administration & dosage / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000521:alpha-MSH / Q000031:analogs & derivatives* / Q000494:pharmacology
D010446:Peptide Fragments; D003366:Cosyntropin; C061020:ACTH (7-16)NH2; D000521:alpha-MSH; C027756:MSH, 4-Nle-7-Phe-alpha-; D000324:Adrenocorticotropic Hormone; D006220:Haloperidol