Intracellular calcium waves generated by Ins(1,4,5)P3-dependent mechanisms.
Cellular oscillations of cytosolic free Ca2+ ([Ca2+]i) have been observed in many cell types in response to cell surface receptor agonists acting through inositol 1,4,5-trisphosphate (InsP3). In a number of cases where appropriate spatial and temporal resolution have been used to examine these [Ca2+]i oscillations, they have been found to be organized as repetitive waves of Ca2+ increase that propagate through the cytosol of individual cells. In some cases Ca2+ waves also occur as a single pass through stimulated cells. This review discusses the factors underlying the spatial organization of [Ca2+]i signals in the form of Ca2+ waves. In addition, potential mechanisms for the initiation and subsequent propagation of these Ca2+ waves are described.
Rooney
T A
TA
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA.
Thomas
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AP
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D002450:Cell Communication; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007424:Intracellular Fluid / Q000378:metabolism; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium