[The effect of endogenous opioid peptides and their synthetic analogs on T-cell immunity].
The effects of the endogenous opioid peptides met- and leu-enkephalins and their synthetic analogs such as DAGO, DADLE, dalargin on the formation and activity of cytolytic T lymphocytes in response to alloantigen stimulation were studied in the unidirectional mixed culture of lymphocytes. It was shown that the maximum stimulating effect of the opioids manifested itself on their addition 24-48 hours after the initiation of incubation and on addition of suboptimal concentrations of an antigen to the culture. The selective opioid receptor ligands mu- and delta-types + (DAGO and DADLE) have a heterodirectional effect on the formation of specific T killer cells in the mixed culture of lymphocytes.
Korostelev
S A
SA
Isakova
K L
KL
Shchegolev
A I
AI
Uteshev
B S
BS
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000187:drug effects / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013268:Stimulation, Chemical; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D004723:Endorphins; D004745:Enkephalins; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie éndogennykh opioidnykh peptidov i ikh sinteticheskikh analogov na T-kletochnyĭ immunitet.