[Diffusion of lipid fractions through the barrier of cantharidin blisters in hyperlipidemias under conditions of clofibrate and rutinosid interaction].
Diffusion of lipid fractions from blood to fluid in blister induced by cantharidal ointment, applied on the forearm skin, was studied in 54 patients, thereof 18 with normlipidemia, 13 having type II hyperlipidemia, 23 with type IV hyperlipidemia. Concentrations of triglycerides, phospholipids, free fatty acids, total cholesterol, HDL-cholesterol and LDL--cholesterol were studied in blood and fluid before treatment, 10 days after applying clofibrate, 20 days after clofibrate application, and 10 days following the application of rutinosid, i.e. upon completion of therapy. After the treatment it was observed that in all the patients the concentration of lipid fractions in blood was lowered, except for HDL-cholesterol, the level of which was elevated, as was the concentration of all the fractions in the blister fluid. Lipid concentration in serum, with the exception of free fatty acids, was invariably higher than in blister fluid. Free fatty acids, LDL-cholesterol and HDL-cholesterol diffused from blood to fluid in a greater percentage. Lipid fraction concentration in fluid depended mainly on the concentration of HDL-cholesterol and triglycerides in the blood. In normlipidemia, the highest percentage of lipid fractions was diffused to blister fluid; the percentage was lower in type IV hyperlipidemia, the lowest being in type II hyperlipidemia. Clofibrate hypolipemia action correlated best with with HDL-cholesterol and triglyceride activity. After the treatment, the elevated diffusion of all the fractions from blood to blister fluid was, in my opinion, consistent with lipid metabolism, venoruton, as vessel tightening drug, may play a protective role in relation to endothelia in hyperlipidemia.
Szamer
B
B
Katedry i Kliniki Chorób Skórnych i Wenerycznych Pomorskiej Akademii Medycznej.
D000279:Administration, Cutaneous; D000328:Adult; D001768:Blister / Q000139:chemically induced* / Q000378:metabolism; D002193:Cantharidin / Q000494:pharmacology*; D004058:Diffusion; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism*; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D006896:Hydroxyethylrutoside; D008055:Lipids; C005865:troxerutin; D002193:Cantharidin
Przenikanie frakcji lipidowych przez bariere pecherza kantarydynowego w hiperlipidemiach w warunkach interakcji klofibratu i rutynozydu.