title: Concurrent invasive thymoma and T-cell lymphoblastic leukemia and lymphoma. A case report with necropsy findings and literature review of thymoma and associated hematologic neoplasm.
abstract: Thymoma is associated with benign and neoplastic diseases. The authors report the concurrence of invasive thymoma and T-lymphoblastic leukemia/lymphoma in a 95-year-old man. The hematologic malignancy was suspected terminally, whereas the thymoma was discovered at necropsy. The lymphoblastic leukemia/lymphoma had a clonally rearranged T-cell receptor beta-chain gene and a mature thymocyte immunophenotype. No retroviral gene sequences (human immunodeficiency virus 1 and 2, and human T-cell leukemia virus 1 and 2) were identified by polymerase chain reaction and hybridization analysis. The association of thymoma with hematologic neoplasm is reviewed.
authors.affiliation: Department of Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Syracuse, New York 13210.
authors.forename: H D
authors.initials: HD
authors.lastname: Friedman
authors.forename: D A
authors.initials: DA
authors.lastname: Inman
authors.forename: R E
authors.initials: RE
authors.lastname: Hutchison
authors.forename: B J
authors.initials: BJ
authors.lastname: Poiesz
mesh_terms: D000008:Abdominal Neoplasms / Q000276:immunology / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000276:immunology / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000276:immunology / Q000473:pathology*; D013945:Thymoma / Q000276:immunology / Q000473:pathology*
chemical_list: D015703:Antigens, CD