title: Production of interleukin-6 and tumour necrosis factor-alpha in vitro is reduced in whole blood of severely malnourished children.
abstract: 1. Cytokine production in vitro was assessed in 16 malnourished children, before and after nutritional recovery. 2. Tumour necrosis factor-alpha and interleukin-6 were measured in whole blood after lipopolysaccharide stimulation. 3. The total amount of both cytokines was significantly less after 24 h incubation among malnourished children when compared with the same children after nutritional rehabilitation. 4. Cytokine production in vitro is impaired in severely malnourished children.
authors.affiliation: Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston, Jamaica.
authors.forename: J F
authors.initials: JF
authors.lastname: Doherty
authors.forename: M H
authors.initials: MH
authors.lastname: Golden
authors.forename: D G
authors.initials: DG
authors.lastname: Remick
authors.forename: G E
authors.initials: GE
authors.lastname: Griffin
mesh_terms: D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D015850:Interleukin-6 / Q000096:biosynthesis*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D009748:Nutrition Disorders / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha