The genetics of breast cancer.
Some of the genetic abnormalities that give rise to human breast cancer have been identified. This article reviews the biology of the oncogenes c-myc and neu and the antioncogene p53. Data supporting the role of these genes in the pathogenesis of human breast cancer are reviewed. Potential diagnostic and therapeutic applications that have developed out of our understanding of the molecular genetics of breast cancer are also discussed.
Morrison
B W
BW
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts.
D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008403:Mass Screening; D011519:Proto-Oncogenes