Physicochemical characterization of acetaminophen-ethylcellulose solid dispersion.
In this study, ethylcellulose was evaluated as a carrier for the preparation of sustained release of acetaminophen via solid dispersion technique. Physical mixture at the same level of acetaminophen and ethylcellulose was prepared. Differential scanning calorimetry and scanning electron microscope were used to characterize the physical properties of the various systems and to determine if there is possible interaction between acetaminophen and ethylcellulose.
Ghaly
E S
ES
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
Hernández
J I
JI
Malavé
A
A
Marti
A
A
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations; D008855:Microscopy, Electron, Scanning
D003692:Delayed-Action Preparations; D000082:Acetaminophen; C013517:ethyl cellulose; D002482:Cellulose