Naturally occurring antiacne agents.
Antibacterial activity of various secondary metabolites from plants against Propionibacterium acnes was tested. In addition, the study of combinations of compounds to enhance the total activity against this follicular bacterium was investigated. A series of long-chain alcohols was studied in great detail to gain new insights into the role of the hydrophobic alkyl groups in the activity.
Kubo
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I
Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley 94720.
Muroi
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H
Kubo
A
A
D000152:Acne Vulgaris / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008560:Membrane Fluidity / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D011425:Propionibacterium acnes / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols