title: An alternative sodium bicarbonate regimen during cardiac arrest and cardiopulmonary resuscitation in a canine model.
abstract: We evaluated the effect of frequent, early bolus administration of low-dose sodium bicarbonate (NaHCO3) on blood gas values during ventricular fibrillation and cardiopulmonary resuscitation (CPR) compared with normal saline and standard bolus doses of NaHCO3. This was a randomized laboratory investigation involving 13 mongrel dogs and 18 experiments (5 dogs were used in a crossover manner). Each dog underwent 3 minutes of ventricular fibrillation, followed by 15 minutes of CPR. Animals were randomly assigned to one of three treatments administered early in the resuscitation effort: NaHCO3 0.5 mEq/kg at 5, 10, and 15 minutes of ventricular fibrillation (SB); NaHCO3 1 mEq/kg at 5 minutes and 0.5 mEq/kg at 15 minutes of fibrillation (SB); or 0.9% NaCl 1 ml/kg at 5 minutes and 0.5 ml/kg at 15 minutes of fibrillation (P). A total of 15 experiments were included for analysis. Arterial and venous blood gases were sampled at 4, 8, 13, and 18 minutes of fibrillation. The SB group demonstrated the highest arterial partial pressures of carbon dioxide (pCO2) at each sampling point after NaHCO3, including the 18-minute sample: 42 +/- 12, 29 +/- 11, and 35 +/- 10 torr for SB, P, and B, respectively. In addition, SB produced arterial alkalemia (pH > 7.45) after NaHCO3 administration. The arterial pH at 18 minutes of fibrillation for SB, P, and B was 7.46 +/- 0.14, 7.29 +/- 0.07, and 7.41 +/- 0.1, respectively. Similar trends for pCO2 and pH were observed for venous samples.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.
authors.forename: B E
authors.initials: BE
authors.lastname: Bleske
authors.forename: T L
authors.initials: TL
authors.lastname: Rice
authors.forename: E W
authors.initials: EW
authors.lastname: Warren
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D016887:Cardiopulmonary Resuscitation; D004195:Disease Models, Animal; D004285:Dogs; D006323:Heart Arrest / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D006439:Hemodynamics / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*; D011897:Random Allocation; D017693:Sodium Bicarbonate / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D002245:Carbon Dioxide; D017693:Sodium Bicarbonate; D010100:Oxygen