Suppression of prostaglandin F2 alpha and oxytocin release after inhibition of testosterone synthesis in the goat.
Increased peripheral plasma concentrations of testosterone were detected in goats on days 13 and 14 of the oestrous cycle (oestrus = day 0), at the onset of luteolysis. Subcutaneous administration of spironolactone (10 mg kg-1 day-1) on days 10 to 19 inhibited the increases in testosterone, delayed luteolysis and suppressed plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F2 alpha and oxytocin. These results suggest that testosterone of follicular or luteal origin, possibly via aromatisation to oestrogens, is needed to expedite luteolysis and induce oestrus in the goat.
Cooke
R G
RG
Department of Veterinary Preclinical Sciences, University of Liverpool Veterinary Field Station, Leahurst, South Wirral, Cheshire.
Ahmad
N
N
D000818:Animals; D015237:Dinoprost / Q000097:blood / Q000378:metabolism*; D004971:Estrus / Q000378:metabolism*; D005260:Female; D006041:Goats / Q000378:metabolism*; D010121:Oxytocin / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay / Q000662:veterinary; D013148:Spironolactone / Q000494:pharmacology; D013739:Testosterone / Q000096:biosynthesis*
D013148:Spironolactone; D013739:Testosterone; D010121:Oxytocin; D015237:Dinoprost