Enhanced recovery of ischemic myocardium by combining percutaneous bypass with intraaortic balloon pump support.
Although percutaneous bypass (PB) can support the failing myocardium, regional ischemic damage may still occur beyond a coronary occlusion. This study sought to determine whether the addition of intraaortic balloon pump (IABP) support to PB would result in more optimal salvage of ischemic myocardium. In 30 pigs, the second and third diagonal vessels were occluded with snares for 90 minutes followed by 30 minutes of cardioplegic arrest and 3 hours of reperfusion with the snares released. During the period of coronary artery occlusion, 10 pigs were placed on PB, 10 pigs received PB plus IABP support, and 10 pigs received no support (the unmodified group). The hearts treated with the combination of PB and IABP support exhibited the highest wall motion scores (3.3 +/- 0.20 for the PB plus IABP group [p < 0.05 from the unmodified group and from the PB group]; versus 1.40 +/- 0.30 for the PB group versus 1.37 +/- 0.33 for the unmodified group), the least tissue acidosis (change in pH, -0.30 +/- 0.2 for the PB plus IABP group [p < 0.05 from the PB group] versus -0.60 +/- 0.10 for the PB group versus -0.41 +/- 0.13 for the unmodified group), and the least area of necrosis (25% +/- 5% for the PB plus IABP group [p < 0.05 from the unmodified group and from the PB group]; versus 43% +/- 2% for the PB group [p < 0.05 from the unmodified group] versus 73% +/- 3% for the unmodified group).(ABSTRACT TRUNCATED AT 250 WORDS)
Lazar
H L
HL
Department of Cardiothoracic Surgery, University Hospital, Boston, Massachusetts 02118.
Treanor
P
P
Yang
X M
XM
Rivers
S
S
Bernard
S
S
Shemin
R J
RJ
D000138:Acidosis / Q000209:etiology / Q000517:prevention & control; D000208:Acute Disease; D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology / Q000517:prevention & control; D002315:Cardiopulmonary Bypass / Q000379:methods; D003131:Combined Modality Therapy; D006321:Heart / Q000503:physiopathology*; D007423:Intra-Aortic Balloon Pumping; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000150:complications / Q000628:therapy*; D009204:Myocardial Revascularization; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D013552:Swine