Is L-carnitine protective in hypoxic cerebral edema in newborn mice?
The value of carnitine in the prevention of cerebral edema due to acute severe hypoxia in 38 newborn mice was studied. Twenty-nine animals received normal saline (0.25 ml) or carnitine (16 mmol/kg) intraperitoneally, thirty minutes before exposure to 0% oxygen in inspired air for two minutes. Nine mice received no drug and were exposed to room air. After hypoxic insult, brain water content was measured and was found to be similar in all groups. These findings suggest that carnitine pretreatment does not prevent brain edema associated with cerebral hypoxia in newborn mice.
Yurdakök
M
M
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Haziroğlu
R
R
Coşkun
T
T
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D001834:Body Water / Q000187:drug effects; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D002331:Carnitine / Q000494:pharmacology / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000150:complications; D051379:Mice; D012720:Severity of Illness Index
D002331:Carnitine