Evaluation of radioprotective action of a mutant (E-25) form of Chlorella vulgaris in mice.
The possible role of orally fed Chlorella vulgaris (E-25) in modulating the gamma-ray induced chromosomal damage in whole-body irradiated mice was evaluated using a micronucleus test. Different doses of E-25 were administered either chronically (once, twice or thrice a day for 28 days) or as single acute doses before/after irradiation. A significant radioprotective effect was observed in both acute and chronic pretreatments, but only at doses above 400 mg/kg body weight. However, in mice that received E-25 (500 mg/kg) three times a day for 28 days, there was no protective effect, and a significant loss in their body weight was observed. Interestingly, E-25 afforded significant radioprotection even when it was administered within 0.4 hr after irradiation.
Sarma
L
L
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Tiku
A B
AB
Kesavan
P C
PC
Ogaki
M
M
D000818:Animals; D002708:Chlorella / Q000235:genetics / Q000502:physiology*; D004912:Erythrocytes / Q000528:radiation effects; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D009154:Mutation; D011835:Radiation Protection; D014916:Whole-Body Irradiation / Q000009:adverse effects