[Failure of empirical treatment with ceftriaxone in motor neuron disease].
We describe two patients with lateral amyotrophic sclerosis who, after informed consent, received empirical treatment with intravenous cephtriaxone at a dose of 2 g/24 hours for three weeks, with no positive results. The pharmacokinetics of this cephalosporin is analyzed, along with the relationship between motor neuron disease, neuroborreliosis and immunoreactivity to Borrelia burgdorferi.
Carod Artal
F J
FJ
Servicio de Neurología, Hospital Miguel Servet, Zaragoza.
Pérez López-Fraile
I
I
Gracia Naya
M
M
Girón Mombiela
J A
JA
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D001899:Borrelia Infections / Q000188:drug therapy / Q000276:immunology; D015748:Borrelia burgdorferi Group / Q000187:drug effects / Q000302:isolation & purification; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004576:Electromyography; D004584:Electronystagmography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
D002443:Ceftriaxone
Fracaso del tratamiento empírico con ceftriaxona en la enfermedad de la motoneurona.