The fragile-X syndrome: a growing gene causing familial intellectual disability.
The fragile-X syndrome is the most common cause of familial intellectual disability. Recently, the gene related to the fragile-X syndrome [the 'fragile-X mental retardation'-1 (FMR-1) gene] has been isolated. In this review, clinical and molecular aspects of the fragile-X syndrome, current benefits and future prospects are discussed.
De Vries
L B
LB
Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands.
Halley
D J
DJ
Oostra
B A
BA
Niermeijer
M F
MF
D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D006580:Genetic Carrier Screening; D005820:Genetic Testing; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D007360:Intelligence / Q000235:genetics; D008297:Male; D010375:Pedigree; D010641:Phenotype