title: Continuous insulin infusions in neonates: pharmacologic availability of insulin in intravenous solutions.
abstract: Continuous insulin infusion is sometimes used in very low birth weight infants with glucose intolerance. We studied the availability of insulin to the neonate by means of a laboratory-simulated clinical infusion under both flushed and non-flushed conditions. Although loss of insulin was noted with both solutions (0.5 U/ml), under the nonflushed condition only 55.9% of the prescribed dose for the first 2 hours was delivered before the delivery rate of the flushed system, 71.4%, was approached. These findings have implications for neonatal insulin administration.
authors.affiliation: School of Nursing, University of California, Los Angeles.
authors.forename: P S
authors.initials: PS
authors.lastname: Simeon
authors.forename: M E
authors.initials: ME
authors.lastname: Geffner
authors.forename: S R
authors.initials: SR
authors.lastname: Levin
authors.forename: A M
authors.initials: AM
authors.lastname: Lindsey
mesh_terms: D000327:Adsorption; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007231:Infant, Newborn; D007262:Infusions, Intravenous / Q000295:instrumentation* / Q000379:methods; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D007328:Insulin