Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development.
Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.
Armstrong
J W
JW
Division of Biology, Kansas State University, Manhattan 66506-4901.
Simske
S J
SJ
Beharka
A A
AA
Balch
S
S
Luttges
M W
MW
Chapes
S K
SK
D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000502:physiology*; D008264:Macrophages / Q000166:cytology* / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II