[Gamma-vinyl-GABA: first experiences in Italy. II].
The long term efficacy of GVG was studied in patients with drug resistant CPC and CPC plus secondarily generalized seizures. GVG was started as monotherapy followed by add-on therapy with carbamazepine (CBZ), phenobarbital (PB), valproate (VPA). The results suggest: 1) loss of efficacy of gamma-vinyl-GABA during long-term use, and 2) at present, GVG appears to be an effective safe antiepileptic drug for initial monotherapy.
de Romanis
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Dipartimento di Scienze Neurologiche, Università degli Studi di Roma La Sapienza.
Sopranzi
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D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D017029:Epilepsy, Complex Partial / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000627:therapeutic use; D010919:Placebos; D012640:Seizures / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use; D020888:Vigabatrin
D000614:Aminocaproates; D000927:Anticonvulsants; D010919:Placebos; D002220:Carbamazepine; D014635:Valproic Acid; D020888:Vigabatrin; D010634:Phenobarbital
Gamma-vinil-GABA: prime esperienze in Italia. Part II.