title: Effect of lesion size on the metabolic activity of tibial dyschondroplastic chondrocytes.
abstract: Experiments were conducted to determine the influence of lesion size and method of producing tibial dyschondroplasia on metabolic activity of cultured chondrocytes. Genetic selection was one method used to produce a high incidence of tibial dyschondroplasia. Chondrocytes obtained from severe lesions exhibited reduced mitogenic activity (3H-thymidine incorporation) and ability to synthesize matrix proteoglycans (35SO4 incorporation) when compared with normal growth plate and smaller lesions. When a commercial broiler strain was used, all chondrocytes isolated from lesions induced by feeding thiram had reduced metabolic activity. Similar results were observed with severe lesions obtained from copper-deficient chicks. It is concluded that lesion size is an important factor in determining subsequent metabolic activity of chondrocytes isolated from tibial dyschondroplastic lesions.
authors.affiliation: Department of Poultry Science, Pennsylvania State University, University Park 16802-3501.
authors.forename: G
authors.initials: G
authors.lastname: Rosselot
authors.forename: C
authors.initials: C
authors.lastname: Sokol
authors.forename: R
authors.initials: R
authors.lastname: Leach
mesh_terms: D000818:Animals; D002645:Chickens / Q000378:metabolism*; D006132:Growth Plate / Q000378:metabolism / Q000473:pathology; D010009:Osteochondrodysplasias / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000378:metabolism* / Q000473:pathology; D013977:Tibia / Q000378:metabolism* / Q000473:pathology