[Urogenital malformation complex including the Mullerian system].
Symptomatic cystic epididymis in a 21-year-old man led to the detection of several genital malformations, including a partially obstructing pelvic cyst, prostatic and bilateral testicular atrophy and penoscrotal hypospadias. These malformations are probably due to a deficiency of either testosterone or müllerian inhibiting hormone (MIH). Development of the male genitalia is influenced by testosterone secreted in the Leydig cells during weeks 8-16 of gestation, while regression of the müllerian ducts is induced by MIH secreted in the Sertoli cells from weeks 9-12 of gestation.
Hochreiter
W
W
Urologische Universitätsklinik, Inselspital, Bern.
Stenzl
A
A
Altermatt
H J
HJ
Kraft
R
R
Spiegel
T
T
D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D054304:Anti-Mullerian Hormone; D003560:Cysts / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D003952:Diagnostic Imaging; D004822:Epididymis / Q000473:pathology / Q000601:surgery; D004823:Epididymitis / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000172:deficiency; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000002:abnormalities*; D011467:Prostate / Q000002:abnormalities / Q000473:pathology; D011469:Prostatic Diseases / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D013735:Testicular Hormones / Q000172:deficiency; D013737:Testis / Q000002:abnormalities / Q000473:pathology; D013739:Testosterone / Q000172:deficiency; D014564:Urogenital Abnormalities; D014566:Urogenital System / Q000473:pathology / Q000601:surgery
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D013739:Testosterone; D054304:Anti-Mullerian Hormone
Urogenitaler Missbildungskomplex mit Einbeziehung des Müller-Systems.