Chemical carcinogenesis as a factor altering the tissue ability to bind hormones. Benzo(a)pyrene--insulin interrelationship.
The present study was carried out on the uptake of 125I-insulin in the tissues or organs (liver, subcutaneous adipose tissue, striated muscle, renal cortex, frontal lobes of the brain) of normal Wistar rats or from animals treated with benzo(a)pyrene, a powerful carcinogen which s metabolically activated in the liver. The carcinogen was administered as follows: (a) in adult life by a single injected dose; (b) in early fetal life by administration to pregnant females and (c) in late fetal life, likewise by administration to the mothers. The results of combined administrations were studied as well. The ability of normal tissues to take up insulin was determined. The administration of a single benzo(a)pyrene dose produced marked alterations in binding of the hormone in some of the tissues, which might be attributed to certain general changes in the properties of the cell membranes. It has to be underlined that after the contact with the carcinogen in fetal life, the tissular ability to take up insulin is irreversibly and non-uniformly altered. This ability is easily influenced by a new carcinogenic dose.
Dragomir
C T
CT
Laboratory of Radiobiology, Victor Babeş Institute of Pathology & Medical Genetics, Bucharest, Romania.
Botea
S
S
Mihalache
D
D
Chirvasie
R
R
Mocanu
M
M
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D005260:Female; D007328:Insulin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism
D007328:Insulin; D007457:Iodine Radioisotopes; D001564:Benzo(a)pyrene; D011972:Receptor, Insulin