title: [Effects of therapy of laryngeal and hypopharyngeal cancers on eustachian tube function].
abstract: In a prospective investigation Eustachian tube function was tested before and after surgery and irradiation of patients suffering from carcinoma of the larynx or hypopharynx. Passive and active tubal parameters were determined using the dual-impedance method in a pressure chamber. In this test, passive tubal function is described by the spontaneous opening and closing characteristics of the tube by an overpressure in the middle ear. Active tubal parameters are determined by the facility of the tube to equalize an over- and underpressure in the middle ear by swallowing. Statistic evaluation was performed with Student's t-test. There were no significant alterations of passive or active tubal function after neck dissection with or without surgery of the primary tumour. On the other hand we observed significant deterioration of all tubal parameters immediately after a series of fractionated percutaneous telecobalt therapy (60 Gy). 2 out of 18 patients developed unilateral middle ear effusion during irradiation which was reversible within 6 months. In most patients we observed a total or at least partial restitution of passive tubal parameters during this time, which was statistically significant. The active tubal function was of minor reversibility. Whereas the facility to equalize a positive pressure in the middle ear was quite good after 6 months, only few patients were able to equalize a negative pressure. The temporary deterioration of passive tubal function may be caused by a marginal implication of the tube at the edge of the irradiation field and by increased lymphatic pressure in tubal tissue following a radiogenic swelling of the lymphatic vessels of the neck.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hals-Nasen-Ohren-Klinik, Albert-Ludwigs-Universität Freiburg.
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: C
authors.initials: C
authors.lastname: Beck
authors.forename: W
authors.initials: W
authors.lastname: Hinkelbein
authors.forename: B
authors.initials: B
authors.lastname: Richter
mesh_terms: D003131:Combined Modality Therapy; D005064:Eustachian Tube / Q000503:physiopathology* / Q000528:radiation effects*; D005500:Follow-Up Studies; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D037981:Neck Dissection; D011183:Postoperative Complications / Q000503:physiopathology*; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
vernacular_title: Auswirkungen der Therapie von Larynx- und Hypopharynx-karzinomen auf die Funktion der Tuba Eustachii.