Fluid-regulating and sympathoadrenal hormonal responses to peak exercise following cardiac transplantation.
Orthotopic heart transplantation results in cardiac denervation that can disrupt the normal regulation of hydromineral balance. This study compared the exercise-induced variations in plasma osmolality; atrial natriuretic peptide (ANP), arginine vasopressin (AVP), norepinephrine (NE), epinephrine (E), and dopamine (DA) concentrations; and plasma renin activity (PRA) of six cardiac transplant recipients (HTX) and six healthy age-matched controls (C) submitted to graded upright maximal cycling. Venous blood samples were obtained at rest, at submaximal (70% O2 uptake) and peak exercise, and after 10 and 30 min of sitting recovery. Peak O2 uptake was not different between groups despite lower maximal heart rate in HTX (136 +/- 6 vs. 183 +/- 9 beats/min). Baseline plasma ANP and PRA were higher in HTX (203 +/- 55 pg/ml and 29.9 +/- 7.4 ng.ml-1 x h-1) than in C (71 +/- 17 pg/ml and 5.4 +/- 0.96 ng.ml-1 x h-1); AVP was lower in HTX than in C (1.1 +/- 0.3 vs. 3.2 +/- 0.8 pg/ml; P < 0.05); and circulating E, NE, and DA were not different between groups. Exercise resulted in more marked increases in HTX than in C for ANP (300 vs. 100%), AVP (2,000 vs. 300%), NE (860 vs. 500%), and DA (611 vs. 187%) but not for PRA and a higher E response in C than in HTX (455 vs. 1,258%). These observations confirm that the potential for ANP release to central volume loading is independent of intact cardiac innervation. The exaggerated AVP response in HTX could, however, reflect the absence of inhibitory influences consecutive to denervation.(ABSTRACT TRUNCATED AT 250 WORDS)
Perrault
H
H
Department of Physical Education, McGill University, Montreal, Quebec, Canada.
Melin
B
B
Jimenez
C
C
Dureau
G
G
Dureau
P
P
Allevard
A M
AM
Cottet-Emard
J M
JM
Gauquelin
G
G
Gharib
C
C
D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D016027:Heart Transplantation / Q000502:physiology*; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013564:Sympathetic Nervous System / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D006728:Hormones; D012964:Sodium; D011188:Potassium