Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.
Peters
G J
GJ
Dept. Oncology, Free University Hospital, Amsterdam, The Netherlands.
Codacci-Pisanelli
G
G
van der Wilt
C L
CL
van Laar
J A
JA
Smid
K
K
Noordhuis
P
P
Pinedo
H M
HM
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000097:blood / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D007263:Infusions, Parenteral; D007274:Injections, Intraperitoneal; D002955:Leucovorin / Q000008:administration & dosage*; D051379:Mice; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D013940:Thymidylate Synthase; D002955:Leucovorin; D005472:Fluorouracil