[Therapeutic effect of azlocillin and its combinations with other antibiotics in experimental plague infection].
The therapeutic effect of azlocillin and its combinations with other antibiotics was studied in a model of experimental plague of albino mice. Azlocillin was shown to be efficient in the prophylaxis and treatment of the experimental plague infection. The optimal doses of azlocillin were determined. The protective action of the drug depended on the dose and the time of its administration. The therapeutic effect was mainly defined by the antibiotic dose. The use of azlocillin in not sufficiently active doses in combination with aminoglycosides (gentamicin, sisomicin and amikacin), rifampicin or doxycycline significantly increased the percentage of the animal survival by comparison with that after the use of every antibiotic alone. A synergistic effect was observed when azlocillin was used in combination with rifampicin or amikacin.
Markovskaia
E I
EI
Makarovskaia
L N
LN
Ryzhkova
V V
VV
Zurabian
V A
VA
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001390:Azlocillin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000517:prevention & control; D012293:Rifampin / Q000627:therapeutic use
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001390:Azlocillin; D004318:Doxycycline; D012293:Rifampin
Lechebnoe deĭstvie azlotsillina i ego sochetaniĭ s drugimi antibiotikami pri éksperimental'noĭ chume.