[Comparative efficacy of 0.1% indomethacin eyedrops, 0.03% flurbiprofen eyedrops and placebo for maintaining peroperative mydriasis].
A randomized, double-blind study was conducted to compare the effect of 0.1% indomethacin solution versus 0.03% flurbiprofen versus placebo on the maintenance of mydriasis during cataract surgery. Ninety-five patients undergoing extracapsular cataract extraction with posterior chamber lens implantation were enrolled. Pupillary diameters were measured horizontally under operating-microscope visualization before 5 surgical steps: 1. corneo-scleral incision; 2. lens nucleus expression; 3. lens cortex material aspiration; 4. intra-ocular lens implantation; 5. end of surgery. The mydriasis loss during surgery was statistically less in the 2 groups treated by non steroidal anti-inflammatory drugs than in the placebo group. This effectiveness appeared at the time of lens nucleus expression (p = 0.0001) and persisted until the end of surgery. Then, the mydriasis was maintained during 2 crucial surgical steps requiring optimal pupillary dilation: lens cortex material aspiration and intra-ocular lens implantation. No significant difference was found between 0.1% indomethacin and 0.03% flurbiprofen concerning effectiveness and tolerance.
Allaire
C
C
Laboratoire Chauvin, Montpellier, Québec, Canada.
Lablache Combier
M
M
Trinquand
C
C
Bazin
R
R
D000328:Adult; D000368:Aged; D002387:Cataract Extraction; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D015877:Miosis / Q000517:prevention & control; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010919:Placebos; D011292:Premedication; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects*
D009184:Mydriatics; D009883:Ophthalmic Solutions; D010919:Placebos; D005480:Flurbiprofen; D007213:Indomethacin
Efficacité comparée de l'indométacine collyre à 0.1%, du flurbiprofène collyre à 0.03% et d'un placebo sur le maintien de la mydriase peropératoire.