Intraperitoneal injection of 1-oleoyl-2-docosahexaenoyl phosphatidylcholine enhances discriminatory shock avoidance learning in rats.
Effects of injection of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (ODHPC) on learning ability were investigated in rats using discriminatory shock avoidance learning task. When ODHPC (2 mumol) was intraperitonealy administered 5 min before the beginning of the first trial of learning task from the second to fifth sessions, avoiding rates of the ODHPC-injected group were significantly higher than those of the control group. However, any injection of ODHPC derivatives, such as 1-oleoyl-2-docosahexaenoyl-diacylglycerol, 1,2-dioleoyl-sn-glycero-3-phosphorylcholine, glycerophosphorylcholine, docosahexaenoate, oleate and choline chloride, did not affect learning. These results suggest that intraperitoneal ODHPC injection enhances learning ability by its specific conformation.
Izaki
Y
Y
Department of Physiology, Yamanashi Medical University, Japan.
Hashimoto
M
M
Arita
J
J
Iriki
M
M
Hibino
H
H
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004597:Electroshock; D007274:Injections, Intraperitoneal; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D010446:Peptide Fragments; D010713:Phosphatidylcholines; C084316:1-oleoyl-2-docosahexaenoyl phosphatidylcholine