title: Conventional cardiopulmonary bypass in neonates. A physiological approach--10 years of experience at Marie-Lannelongue Hospital.
abstract: There is still controversy about the optimal method of venoarterial cardiopulmonary bypass (CPB) for correction of congenital heart disease in neonates and young infants. High rates of CPB-related morbidity and mortality are still reported. Since 1980, conventional CPB with double caval cannulation with right-angled cannulae has been used in the high majority of neonates at Marie-Lannelongue Hospital. The extracorporeal circuit was miniaturized to be primed with a volume as small as possible. Priming (500 ml) was done with packed red cells and fresh frozen plasma. CPB was conducted at 30% haematocrit and normal ranges of flow rate, arterial pressure, systemic vascular resistances and oxygen delivery. These normal physiological parameters were also maintained during hypothermia. During the last two years, 151 neonates below 15 days old who underwent open-heart surgery were reviewed. The overall hospital mortality was 7.24%. None of the survivors had postoperative complications related to CPB. All physiological and biological values remained within normal ranges during the postoperative course.
authors.affiliation: Department of Pediatric Cardiac Surgery, Centre Chirurgical Marie-Lannelongue, Le Plessis Robinson.
authors.forename: F
authors.initials: F
authors.lastname: Nicolas
authors.forename: J P
authors.initials: JP
authors.lastname: Daniel
authors.forename: J
authors.initials: J
authors.lastname: Bruniaux
authors.forename: A
authors.initials: A
authors.lastname: Serraf
authors.forename: F
authors.initials: F
authors.lastname: Lacour-Gayet
authors.forename: C
authors.initials: C
authors.lastname: Planche
mesh_terms: D002315:Cardiopulmonary Bypass; D005112:Extracorporeal Circulation; D006330:Heart Defects, Congenital / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007231:Infant, Newborn; D012189:Retrospective Studies