title: Sleep and suicidality in psychotic patients.
abstract: The purpose of the study was to determine whether polysomnographic rapid eye movement (REM) sleep parameters distinguish between psychotic patients with and without a history of suicidal behavior. We examined both hand-scored and automated measures of rapid eye movement (REM) sleep in psychotic patients with and without a history of suicidal ideation or attempts. Patients with suicidal behavior had significantly increased REM activity and time both in the whole night data and in the first REM period. These findings suggest an association between REM sleep abnormalities and suicidal behavior, perhaps related to alteration in serotonergic function.
authors.affiliation: University of Pittsburgh Medical School, Western Psychiatric Institute and Clinic, Pennsylvania 15213.
authors.forename: M S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: C F
authors.initials: CF
authors.lastname: Reynolds
authors.forename: D
authors.initials: D
authors.lastname: Montrose
authors.forename: J
authors.initials: J
authors.lastname: Miewald
authors.forename: C
authors.initials: C
authors.lastname: Downs
authors.forename: E M
authors.initials: EM
authors.lastname: Sabo
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D013405:Suicide / Q000523:psychology*; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*; D000092864:Suicide Prevention