[Pneumocystosis in mice under the conditions of a secondary immunodeficiency and with specific immunological tolerance for Pneumocystis carinii].
To study pneumocystosis and to develop the method of its reliable diagnosis, two mouse models of this disease were created. In model 1 mice with T helpers eliminated by means of monoclonal antibodies (McAb) to T-cell marker L3T4 were used. For this purpose mice were injected intraperitoneally with McAb and then infected with P. carinii. In model 2 tolerance to P. carinii was induced in mice by the injection of cyclophosphamide and the animal were then also infected with P. carinii. In both cases the number of cysts in the lungs of the test animals significantly increased in comparison with that in the lungs of the controls. The data obtained in this study indicate that in animals treated in both ways an increase in the sensitivity of the host to this infective agent occurred.
Savitskiĭ
I G
IG
Cherniakhovskaia
I Iu
IIu
Kondrat'eva
T K
TK
Mikheeva
N V
NV
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000946:Antigens, Fungal / Q000008:administration & dosage; D003348:Cortisone / Q000008:administration & dosage / Q000031:analogs & derivatives; D003520:Cyclophosphamide / Q000008:administration & dosage; D004195:Disease Models, Animal; D007108:Immune Tolerance / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011010:Pneumocystis / Q000276:immunology*; D011020:Pneumonia, Pneumocystis / Q000209:etiology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013934:Thymectomy
D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D003520:Cyclophosphamide; D003348:Cortisone
Pnevmotsitoz u mysheĭ v usloviiakh vtorichnogo immunodefitsita i pri spetsificheskoĭ immunologicheskoĭ tolerantnosti k Pneumocystis carinii.