Theoretical analysis of coronary blood flow and tissue oxygen pressure-control.
Coronary blood flow is tightly coupled to the myocardial oxygen consumption. We have presented a control model based on the assumption that the tissue oxygen pressure is the controlled variable. The coronary blood flow in itself is not a controlled variable but merely the result of a different control system: the tissue oxygen pressure. From our control equation there is no relation between the slope of the autoregulation curve and the gain of the tissue PO2 control system. The slope is independent of the level of oxygen consumption.
Spaan
J A
JA
Department of Medical Physics and Informatics, University of Amsterdam AMC, The Netherlands.
Dankelman
J
J
D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D008433:Mathematics; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D010313:Partial Pressure