Anti-inflammatory and wound healing activity of a growth substance in Aloe vera.
Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.
Davis
R H
RH
Department of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.
Donato
J J
JJ
Hartman
G M
GM
Haas
R C
RC
D000504:Aloe; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003436:Croton Oil; D006133:Growth Substances / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008360:Mannosephosphates / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D006133:Growth Substances; D008360:Mannosephosphates; D010936:Plant Extracts; C027693:mannose-6-phosphate; D003436:Croton Oil