Analysis of airway function of immature whole lung transplants versus mature lobar transplants.
For the pediatric patient with end-stage lung disease in need of transplantation, two potential donor options currently exist: size-matched immature whole lungs or reduced-size mature lobes. To determine which of these options provides superior long-term function, we studied airway mechanics in a chronic porcine model of pediatric lung transplantation. Three groups of animals were studied: the first group underwent left upper lobectomy at 9 +/- 1 weeks of age (innervated left lower lobes). These animals served as controls. A second group of 9-week-old animals received an immature whole left lung allograft from age-matched donors. The third group received a reduced-size mature left lower lobe from 6-month-old donors. Measurements of dynamic airway resistance, pulmonary compliance, and functional residual capacity of the isolated lobes or lungs, and of the nonoperated right lungs, were recorded 12 +/- 1 weeks later, and mean values were calculated for each group. Results showed that transplantation of an immature whole lung resulted in abnormal dynamic airway resistance to airflow, which was not seen in the mature lobar transplants. In addition, compliance was impaired most significantly in the immature whole lung transplants. We conclude that in this experimental model of pediatric lung transplantation, transplantation of a mature lobar segment results in superior long-term airway function when compared with immature whole lung transplants.
Kern
J A
JA
Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Tribble
C G
CG
Zografakis
J G
JG
Cassada
D C
DC
Chan
B B
BB
Kron
I L
IL
D000367:Age Factors; D000403:Airway Resistance; D000818:Animals; D005652:Functional Residual Capacity; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008170:Lung Compliance; D016040:Lung Transplantation / Q000379:methods; D011859:Radiography; D015656:Respiratory Mechanics; D013552:Swine; D014019:Tissue Donors