Acetazolamide-induced nephrolithiasis: implications for treatment of neuromuscular disorders.
Carbonic anhydrase inhibitors can cause nephrolithiasis. We studied 20 patients receiving long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another, permitting continued treatment. Renal function remained normal in all patients. Nephrolithiasis is a complication of acetazolamide but does not preclude its use.
Tawil
R
R
Neuromuscular Disease Center, University of Rochester School of Medicine and Dentistry, NY 14642.
Moxley
R T
RT
Griggs
R C
RC
D000086:Acetazolamide / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009224:Myotonia Congenita / Q000188:drug therapy; D010243:Paralysis / Q000188:drug therapy
D000086:Acetazolamide