title: [A case of progressive multifocal leucoencephalopathy during chronic lymphocytic leukaemia].
abstract: We report here a case of PML in the course of untreated chronic lymphocytic leukaemia. The diagnosis of PML was based on the presence of typical histologic findings in the white matter: focal demyelination, abnormal oligodendroglia with basophilic intranuclear inclusions and enlarged bizarre astrocytes. It was confirmed by immunohistochemistry which revealed JC papova-virus antigens in brain tissue and by in-situ hybridization which showed JC virus genomic DNA in oligodendroglial nuclei. Virus particles in the nuclei of abnormal oligodendrocytes and astrocytes were demonstrated by thin-section electron-microscopy.
authors.affiliation: Kliniki Neurologicznej II Wydz. Lek. AM, Warszawie.
authors.forename: T
authors.initials: T
authors.lastname: Nowak-Michalska
authors.forename: M
authors.initials: M
authors.lastname: Barcikowska
authors.forename: E
authors.initials: E
authors.lastname: Kida
authors.forename: H
authors.initials: H
authors.lastname: Budka
authors.forename: P P
authors.initials: PP
authors.lastname: Liberski
mesh_terms: D000368:Aged; D001253:Astrocytes / Q000276:immunology / Q000648:ultrastructure; D001921:Brain / Q000276:immunology; D004279:DNA, Viral; D003711:Demyelinating Diseases; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007577:JC Virus / Q000302:isolation & purification; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000276:immunology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D008854:Microscopy, Electron; D009836:Oligodendroglia / Q000276:immunology / Q000648:ultrastructure; D027383:Papillomaviridae / Q000302:isolation & purification; D027382:Polyomaviridae; D014057:Tomography, X-Ray Computed
chemical_list: D004279:DNA, Viral
vernacular_title: Przypadek postepujacej wieloogniskowej leukoencefalopatii w przebiegu przewlekłej białaczki limfatycznej.