title: Modulation of lamprey fictive swimming and motoneuron physiology by dopamine, and its immunocytochemical localization in the spinal cord.
abstract: The distribution of dopamine immunoreactivity (DA-IR) in lamprey spinal cord was examined using antibodies to dopamine. This revealed a population of small cells slightly ventral to the central canal, with processes extending to it. Ventral to the cells is a sparse plexus of DA-IR fibers. Bath application of DA during glutamate-induced fictive swimming caused cycle rate acceleration at 0.1-1 microM, but slowed the rhythm at higher concentrations (10 microM-1 mM). Bath application or pressure ejection of DA onto spinal motoneurons reduced the late afterhyperpolarization phase of action potentials by 40-50%, without affecting input resistance, membrane potential, or action potential amplitude or duration.
authors.affiliation: Department of Biology, Marquette University, Milwaukee, WI 53233.
authors.forename: D R
authors.initials: DR
authors.lastname: McPherson
authors.forename: C P
authors.initials: CP
authors.lastname: Kemnitz
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D005110:Extracellular Space / Q000502:physiology; D007150:Immunohistochemistry; D007798:Lampreys / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D013045:Species Specificity; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D013550:Swimming
chemical_list: D004298:Dopamine