Bupropion overdose and seizure.
There is little experience with overdose of the relatively new antidepressant bupropion. The case of an 18-year-old healthy adult female patient after an intentional ingestion of 9 g of bupropion is presented. Her hospital course was significant for grand mal seizures, sinus tachycardia without conduction abnormality, and complete neurological recovery. The first pure bupropion overdose in the emergency medicine literature is presented, and the literature pertinent to emergent management of this new antidepressant is reviewed.
Storrow
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AB
Department of Emergency Medicine, Joint Military Medical Centers, Lackland Air Force Base, San Antonio, TX 78236-5300.
D000293:Adolescent; D016642:Bupropion / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D002606:Charcoal / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D062787:Drug Overdose / Q000097:blood / Q000150:complications / Q000628:therapy; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D013012:Sorbitol / Q000627:therapeutic use; D013406:Suicide, Attempted; D013616:Tachycardia, Sinus / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D016642:Bupropion; D002606:Charcoal; D013012:Sorbitol; D003975:Diazepam