title: Deoxyspergualin--a novel immunosuppressant.
abstract: DSG appears to have a unique, although as yet undefined, mechanism of action and may be a useful immunosuppressive agent. Because DSG is effective in reducing preformed antibodies in the xenograft situation, it may have a significant advantage in ABO-incompatible grafts in transplant recipients with high panel-reactive antibodies. Most important, DSG may have a definitive role in immunosuppressive therapy for pancreatic grafts.
authors.affiliation: Transplantation Services, University Hospital, Boston, MA.
authors.forename: R M
authors.initials: RM
authors.lastname: Jindal
authors.forename: M A
authors.initials: MA
authors.lastname: Tepper
authors.forename: K
authors.initials: K
authors.lastname: Soltys
authors.forename: S I
authors.initials: SI
authors.lastname: Cho
mesh_terms: D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016035:Pancreas Transplantation; D014181:Transplantation Immunology
chemical_list: D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus