title: Expression of the transcripts initiated in the 62nd intron of the dystrophin gene.
abstract: The pattern of expression of two distal transcripts initiated in the 62nd intron of the dystrophin gene was investigated under different circumstances; (i) during the development of different rat tissues these transcripts and Dp71, a protein encoded by one of them, increased with brain development and decreased with muscle development; (ii) in cultured glial and neuronal cells, the distal promoter was coactivated with tissue-specific upstream promoters, the muscle-type promoter in glial cells and the brain-type promoter in neuronal cells, which suggests that activity of the upstream promoter does not interfere with activity of the distal promoter; (iii) in lymphoblasts of DMD patients with various deletions of the dystrophin gene, the most distal of which included the 56th intron, the production of the distal transcript was not perturbed.
authors.affiliation: ICGM, U129, INSERM, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Lambert
authors.forename: P
authors.initials: P
authors.lastname: Chafey
authors.forename: J P
authors.initials: JP
authors.lastname: Hugnot
authors.forename: A
authors.initials: A
authors.lastname: Koulakoff
authors.forename: Y
authors.initials: Y
authors.lastname: Berwald-Netter
authors.forename: C
authors.initials: C
authors.lastname: Billard
authors.forename: G E
authors.initials: GE
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Kahn
authors.forename: J C
authors.initials: JC
authors.lastname: Kaplan
authors.forename: H
authors.initials: H
authors.lastname: Gilgenkrantz
mesh_terms: D000818:Animals; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D016189:Dystrophin / Q000096:biosynthesis* / Q000235:genetics*; D017353:Gene Deletion; D015870:Gene Expression; D006801:Humans; D007438:Introns; D008099:Liver / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008969:Molecular Sequence Data; D009136:Muscular Dystrophies / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D051381:Rats; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D016189:Dystrophin