Rat salivary gland blood flow and blood-to-tissue partition coefficients following X-irradiation.
Effects of a single high dose of X-irradiation (15 Gy) to the head and neck region in adult male rats were examined. Three days after radiation, rats were infused with [14C]-iodoantipyrine (IAP) via the femoral vein. Animals were killed at designated times thereafter and the three major salivary glands removed. The uptake of IAP by these tissues was analysed using a pharmacokinetic model. Radiation had relatively modest effects on all measured variables when compared with results from the non-irradiated control and pair-fed groups.
Hiramatsu
Y
Y
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
Nagler
R M
RM
Fox
P C
PC
Baum
B J
BJ
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000528:radiation effects; D012463:Saliva / Q000737:chemistry; D012469:Salivary Glands / Q000098:blood supply* / Q000528:radiation effects*
D000983:Antipyrine; C008135:iodoantipyrine