title: [A histogenetic study on the carcinogenesis of colonic mucous membrane glands induced by 1,2-dimethylhydrazine in rats].
abstract: The relationship between atypical proliferation and carcinogenesis of colonic mucous membrane glands induced by different doses of 1,2-dimethylhydrazine (DMH) was studied by use of histopathological methods and sequential endoscopic observation. The results showed a significant increase of atypical glands in the flat mucosa with the increase in number of DMH injections, the degree of atypical proliferation becoming more serious with the increase of glandular ducts. The following changes were observed under sequential endoscopy: small elevations were first seen on the flat mucosa, then in sequence-flat elevations, hemisphere elevations, substem elevations and finally, stemmed elevations. At the same time, changes such as rubifaction, erosion, central depression and hemorrhage on the tumor surface were frequently encountered. It is concluded that atypical glandular proliferation in the flat mucosa of the colon is a precancerous lesion of colonic carcinoma.
authors.affiliation: Department of Laser, 3rd. Teaching Hospital, Norman Bethune University of Medical Sciences, Changchun.
authors.forename: S J
authors.initials: SJ
authors.lastname: Jin
authors.forename: Y L
authors.initials: YL
authors.lastname: Li
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004127:Dimethylhydrazines; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004127:Dimethylhydrazines