[Antioxidative effect of mammalian liver hydrolyzate on lipid peroxidation].
The antioxidative effect of the mammalian liver hydrolyzate preparation (LH) was investigated mainly in the mouse liver homogenates. At lower concentrations, LH stimulated lipid peroxidation induced by Fe2+ and ascorbic acid in the homogenates, but inhibited completely the oxidation at higher concentrations. LH also inhibited the peroxidation of linolenic acid and linoleic acid. LH reduced 1,1-diphenyl-2-picrylhydrazyl, a free radical model, in a concentration-dependent manner, suggesting that the radical scavenging property of LH is involved in its antioxidative action. Fe2+ and glutathione, contained in LH, seem to act as a stimulator and an inhibitor of peroxidation, respectively.
Aimoto
T
T
Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Hirata
M
M
Hiraki
Y
Y
Dote
C
C
Inoue
N
N
Imai
K
K
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry*; D008297:Male; D051379:Mice; D014020:Tissue Extracts / Q000494:pharmacology*
D000975:Antioxidants; D014020:Tissue Extracts