title: [Successful thrombolysis of a thrombosed mitral valve prosthesis].
abstract: Thrombosis of a cardiac valve prosthesis is a rare but life-threatening event. The diagnosis may be suspected clinically and verified by Doppler echocardiography and/or fluoroscopy. Thrombolysis is being increasingly used as an alternative to emergency surgery (thrombectomy or prosthesis replacement). We describe the clinical course of successful thrombolysis of a thrombosed double leaflet Carbomedics No 29 prosthesis in mitral position, using urokinase, in an elderly female presenting with severe NYHA class IV dyspnea. Thrombolysis should be considered as a first line of treatment for thrombosed cardiac valve prostheses. The addition of a platelet inhibitor is warranted in patients with an episode of prosthetic cardiac valve thrombosis under adequate oral anticoagulation.
authors.affiliation: Kardiologische Abteilung, Medizinische Universitätsklinik, Inselspital Bern.
authors.forename: P
authors.initials: P
authors.lastname: Wagdi
authors.forename: B
authors.initials: B
authors.lastname: Aeschbacher
authors.forename: R
authors.initials: R
authors.lastname: Monotti
authors.forename: B
authors.initials: B
authors.lastname: Meier
mesh_terms: D000368:Aged; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000000981:diagnostic imaging; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Erfolgreiche Thrombolyse einer thrombosierten Mitralklappenprothese.