title: Stereotactic radiosurgery for acoustic nerve tumors in patients with useful preoperative hearing: results at 2-year follow-up examination.
abstract: Twenty patients with acoustic nerve tumors (mean diameter < or = 30 mm) and useful preoperative hearing were examined 2 years after stereotactic radiosurgery to determine the effectiveness of the surgery in the control of tumor growth and the preservation of cranial nerve function. Results showed tumor volume stabilization (12 cases) or reduction (seven cases) was achieved in a total of 19 patients (95%). Useful hearing (defined as Gardner and Robertson Class I or II) preservation was obtained in 100% of cases immediately postoperatively, 50% at 6 months, and 45% at both 1 and 2 years. Two years after stereotactic radiosurgery, facial nerve function was preserved in 90% of patients and 75% continued to have normal trigeminal nerve function. All patients returned to and maintained their preoperative functional status within 3 to 5 days after radiosurgery. These findings indicate that stereotactic radiosurgery with multiple isocenters and narrow radiation beams is a safe and effective management strategy for progressive acoustic nerve tumors. Auditory, facial, and trigeminal nerve function can be preserved in most patients. Prevention of further growth and preservation of cranial nerve function appear to be satisfactory goals in the current management of patients with acoustic neuromas.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: O K
authors.initials: OK
authors.lastname: Ogunrinde
authors.forename: L D
authors.initials: LD
authors.lastname: Lunsford
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
mesh_terms: D000328:Adult; D000368:Aged; D003390:Cranial Nerve Neoplasms / Q000503:physiopathology / Q000601:surgery*; D003391:Cranial Nerves / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006309:Hearing; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D013238:Stereotaxic Techniques; D016896:Treatment Outcome; D000160:Vestibulocochlear Nerve Diseases / Q000503:physiopathology / Q000601:surgery*