Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency.
A 67-yr-old man with chronic cardiopulmonary disease exhibited severe hepatic and moderately severe renal injury after short-term ingestion of therapeutic doses of acetaminophen (1 to 3 gm/day for 3 days). Drug metabolism and other studies, performed 5 mo after recovery from the acute insult, indicated that the patient had decreased rates of hepatic metabolism of acetaminophen to its primary, nontoxic metabolites and decreased kidney function that was compromised further by acetaminophen ingestion. He also had abnormally low concentrations of hepatic and plasma reduced glutathione. Alcohol abuse and malnutrition could not be implicated in the pathogenesis of injury; rather it appeared that advancing age with chronic renal, cardiac and pulmonary insufficiency contributed to acetaminophen toxicity in this patient.
Bonkovsky
H L
HL
Department of Medicine, University of Massachusetts Medical School, Worcester 01655.
Kane
R E
RE
Jones
D P
DP
Galinsky
R E
RE
Banner
B
B
D000082:Acetaminophen / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D000368:Aged; D000437:Alcoholism; D002908:Chronic Disease; D005978:Glutathione / Q000097:blood; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D009748:Nutrition Disorders; D051437:Renal Insufficiency / Q000150:complications*
D000082:Acetaminophen; D005978:Glutathione