[Receptor-mediated endothelial vascular regulation (brief report)].
By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation. The described process is attenuated by pathologic conditions such as e.g. hyperlipidaemia and hypertension. Furthermore, in the case of experimental hypertension, the production of contractile endothelial factors, which weaken the effect of the vasodilatory endothelial factors, is likely to increase. Obviously, an efficient antihypertensive therapy prevents from this endothelial dysfunction, at least in animal experiments.
Lüscher
T F
TF
Medizinische Universitätsklinik, Kardiologische Abteilung, Inselspital, Bern, Schweiz.
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000502:physiology*
D011956:Receptors, Cell Surface
Rezeptor-vermittelte endotheliale Gefässregulation. (Kurzreferat).