Effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals.
The effects of ferric chloride and deferoxamine, an iron chelator, on cisplatin-induced emesis were studied in Suncus murinus. Pretreatment with ferric chloride (FeCl3, 16-64 mg/kg) increased the number of 20 mg/kg cisplatin-induced vomiting episodes. Deferoxamine (256 mg/kg) significantly reduced the number of vomiting episodes and prolonged the latency. These results further support the involvement of free radicals in the generation of cisplatin-induced emesis.
Matsuki
N
N
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Torii
Y
Y
Saito
H
H
D000818:Animals; D002712:Chlorides; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D003676:Deferoxamine / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology*; D005609:Free Radicals; D007274:Injections, Intraperitoneal; D012788:Shrews; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control*
D002712:Chlorides; D005290:Ferric Compounds; D005609:Free Radicals; D003676:Deferoxamine; D002945:Cisplatin; C024555:ferric chloride