[Silastic gel and elastomer in the cicatrization of wounds in the rabbit].
The aim of this experimental study was to examine two new wound healing adjuvants. Four experimental wounds were created on the back of rabbits to compare the kinetics of wound healing after applying the standard treatment, Silastic gel, and elastomer with and without compounds known to act on wound healing. We observed a tendency towards more rapid healing in the gel groups (13.7 days), the elastomer group (17.3 days) and the elastomer with active compound group (15.3 days) compared with the control group (17.3 days) and the standard treatment group (17.8 days). The differences were not however statistically different. Elastomer is the better carrier for active wound healing compounds because it has better stability over time. Silicon dressings are interesting for wound healing because they give satisfactory results in terms of healing time and in terms of redressing and patient comfort.
Aubert
J P
JP
Service de Chirurgie Plastique, Hôpital de la Conception, Marseille.
Magalon
G
G
D000818:Animals; D003851:Deoxyribonucleases / Q000494:pharmacology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D005341:Fibrinolysin / Q000494:pharmacology; D005447:Fluocinonide / Q000494:pharmacology; D005672:Fusidic Acid / Q000494:pharmacology; D005782:Gels; D011817:Rabbits; D012826:Silicone Elastomers / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D004338:Drug Combinations; D005782:Gels; D012826:Silicone Elastomers; D005447:Fluocinonide; D005672:Fusidic Acid; D003851:Deoxyribonucleases; D005341:Fibrinolysin
Le gel et l'élastomère de Silastic dans la cicatrisation des plaies chez le lapin.