[Antioxidant action of garlic oil and allitridi].
The lipid peroxidation and chemiluminescence (CL) of mouse liver mitochondria induced by a Vc/FeSO4 reaction system was greatly inhibited by garlic oil (GO) and allitridi (Alt) at 0.1 mg/ml. HpD-induced photohemolysis was moderately inhibited by garlic oil (25 micrograms/ml) and allitridi (20 micrograms/ml). Allitridi (200 micrograms/ml) effectively prevented inactivation of red cell membrane acetylcholine sterase (AchEs) caused by .OH, and at 250 micrograms/ml it markedly inhibited blood CL stimulated by croton oil. Garlic oil (5 micrograms/ml) and allitridi (100 micrograms/ml) significantly increased O2-. production. Allitridi at 0.25 mg/ml and 1 mg/ml enhanced lipid peroxidation of mitochondria and blood CL caused by H2O2.
Fu
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Cancer Institute, CAMS and PUMC, Beijing.
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers; D008163:Luminescent Measurements; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D013440:Sulfides / Q000494:pharmacology*
D000498:Allyl Compounds; D000975:Antioxidants; D016166:Free Radical Scavengers; D013440:Sulfides; C042577:diallyl trisulfide; C038491:allyl sulfide