[Mechanism of hematopoietic disorders in primary experimental hypothyroidism].
In male BALB/c mice and male Wistar rats, primary hypothyrosis was induced by potassium perchlorate whose 1% solution was given to the experimental animals instead of portable water for 3 months. Blood features and medullary hemopoiesis were studied. The changes of the parameters under study were unidirectional in the two animal species, but they were more profound in the rats. The animals with primary hypothyrosis had lower counts of erythrocytes, reticulocytes, and hemoglobin. The bone marrow exhibited a reduction in the total count of myelokaryocytes, suppressed proliferative activity of immature cells and erythroid and myeloid populations. Examining the effects of T3 on cultured bone marrow cells of hypothyrosis rats revealed a sharp T3-induced increase in the count of erythroid cells and the level of their K-mitoses.
Shevtsova
N M
NM
Kozlov
Iu A
IuA
Novitskiĭ
V V
VV
D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D017208:Rats, Wistar
K mekhanizmu narusheniia gemopoéza pri pervichnom éksperimental'nom gipotireoze.