Direct projections from the non-laminated divisions of the medial geniculate nucleus to the temporal polar cortex and amygdala in the cat.
The medial geniculate nucleus (MG) is well known to send projection fibers not only to the auditory cortex, but also to the limbic structures of the forebrain including the perirhinal cortex and amygdala. In the cat, the non-laminated portions of the MG are also known to project to the amygdala, as well as to the auditory cortical areas surrounding the primary auditory area. On the other hand, projections from the non-laminated MG to the limbic cortical areas have not so far been studied systematically. Thus, in the present study, direct projections from the non-laminated portions of the medial geniculate nucleus to the temporal polar cortex and amygdala were examined in the cat by retrograde and anterograde tract-tracing techniques. The temporal polar cortex is the ventral polar region of the posterior sylvian and posterior ectosylvian gyri, which is located dorsal to the posterior rhinal sulcus and includes the ectorhinal area. After injection of cholera toxin B subunit into the temporal polar cortex, retrogradely labeled neurons were seen in the caudal two-thirds of the medial geniculate nucleus ipsilateral to the injection; they were distributed in the non-laminated portions of the MG (the dorsal and medial divisions and the ventromedial part of the ventral division), but not in the laminated portion (the principal part of the ventral division). These findings were confirmed by injecting Phaseolus vulgaris leucoagglutinin into each division of the MG. After the injection into each non-laminated division, terminal labeling was observed in the temporal polar cortex. Terminal labeling was further found in the lateral amygdaloid nucleus ipsilateral to the injection. Then, cholera toxin B subunit was injected into the lateral amygdaloid nucleus; retrogradely labeled neurons were observed ipsilaterally in the non-laminated portions of the MG, as well as in the temporal polar cortex. The results indicate that the non-laminated portions of the MG send projection fibers to the temporal polar cortex and lateral amygdaloid nucleus, and that the non-laminated portions of the MG and temporal polar cortex give rise to overlapping projections to the lateral amygdaloid nucleus. These connections appear to constitute neuronal links in "emotional" and/or "motivational" circuitry in the forebrain.
Shinonaga
Y
Y
Department of Morphological Brain Science, Faculty of Medicine, Kyoto University, Japan.
Takada
M
M
Mizuno
N
N
D000679:Amygdala / Q000166:cytology / Q000502:physiology*; D000818:Animals; D002415:Cats; D002772:Cholera Toxin; D005260:Female; D005829:Geniculate Bodies / Q000166:cytology / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010835:Phytohemagglutinins; D013702:Temporal Lobe / Q000166:cytology / Q000502:physiology*
D010835:Phytohemagglutinins; C100156:leukoagglutinins, plants; D002772:Cholera Toxin