Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency.
The effect of thalidomide on circulating cytokines and myocardial lesion formation was investigated in Mg-deficient rats. After two weeks on a Mg-deficient diet, rats show an increase in circulating levels of tumor necrosis factor-alpha and interleukin 1. Thalidomide (1 mg/day) caused a complete inhibition of the increase in circulating tumor necrosis factor-alpha levels, without having an effect on interleukin 1. However, a marked increase in cardiomyopathic lesion formation was observed in Mg-deficient animals treated with thalidomide; possible mechanisms for thalidomide's enhancement of myocardial injury are discussed.
Weglicki
W B
WB
Department of Medicine, George Washington University Medical Center, Washington, DC 20037.
Stafford
R E
RE
Dickens
B F
BF
Mak
I T
IT
Cassidy
M M
MM
Phillips
T M
TM
D000818:Animals; D004195:Disease Models, Animal; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013792:Thalidomide / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide