BE-23372M, a novel protein tyrosine kinase inhibitor. III. Synthesis.
In a preceding paper, the physico-chemical properties and structural elucidation of BE-23372M, a potent novel protein tyrosine kinase inhibitor, were described. In this paper, we report the synthesis of BE-23372M from 3-(3,4-dimethoxybenzoyl)propionic acid and veratraldehyde or 3,4-diacetoxy-benzaldehyde. The structure of BE-23372M was confirmed to be (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-fur anone.
Tanaka
S
S
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
Okabe
T
T
Nakajima
S
S
Yoshida
E
E
Morishima
H
H
D005663:Furans / Q000138:chemical synthesis*; D010636:Phenols / Q000138:chemical synthesis*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
D005663:Furans; D010636:Phenols; C087122:BE 23372M; D011505:Protein-Tyrosine Kinases