Scleroderma renal crisis as a possible complication of cyclosporin A withdrawal.
The pharmacological treatment of systemic sclerosis (SSc) has been discouraging. In view of this, therapeutic trials with cyclosporine A (CyA) are outstanding particularly in patients with a rapid cutaneous involvement. We report the case of a patient whose SSc cutaneous manifestations dramatically improved with CyA therapy. Its subsequent withdrawal led to a quick onset of a fatal sclerodermal renal crisis. We believe that in our patient there could have been a cause and effect relationship between the suspension of CyA and kidney sclerodermal complication.
Casoli
P
P
2nd Department of Medicine, Santa Maria Nuova Hospital, Reggio Emilia, Italy.
Carretti
C
C
Tumiati
B
B
D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D051437:Renal Insufficiency / Q000139:chemically induced*; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome
D016572:Cyclosporine