title: Cold thyroid nodules: a new application of percutaneous ethanol injection treatment.
abstract: Sonographically guided percutaneous ethanol injection (PEI) has been recently used with excellent results in the treatment of toxic and pretoxic thyroid adenoma. The aim of the present study was to assess the efficacy of PEI also in the treatment of "cold" thyroid nodules. Twenty patients, each with a single thyroid nodule, underwent PEI. In all cases the nodules were found to be cold by thyroid scintiscan. A total of 16.1 mL +/- 3.1 mL of ethanol was injected once a week. No adverse effects were observed during therapy. A striking nodular shrinkage was obtained in all cases, ranging from 72.8% to 97.6% (mean 84.5%, p < 0.001 vs pretreatment volume). These preliminary results suggest that PEI is an effective and safe therapy that may be useful in the treatment of thyroid nodules as an alternative to other therapies (surgery, L-thyroxine).
authors.affiliation: Department of Emergency Surgery, University of Pisa, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Goletti
authors.forename: F
authors.initials: F
authors.lastname: Monzani
authors.forename: M
authors.initials: M
authors.lastname: Lenziardi
authors.forename: P V
authors.initials: PV
authors.lastname: Lippolis
authors.forename: F
authors.initials: F
authors.lastname: De Negri
authors.forename: N
authors.initials: N
authors.lastname: Caraccio
authors.forename: E
authors.initials: E
authors.lastname: Cavina
authors.forename: L
authors.initials: L
authors.lastname: Baschieri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000431:Ethanol / Q000008:administration & dosage*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014463:Ultrasonography
chemical_list: D000431:Ethanol