[Experimental model of induction in the rat of rapidly developing biliary cirrhosis in peripartal nodular cirrhosis].
The treatment with CCl4 and progesterone subsequent the common biliary duct ligature induced, in the rat, after 4-5 weeks, a cirrhotic picture characterized by an early and strong biliary epithelium proliferation followed by a perilobular fibrosis with a concentric sclerosis as in true perilobular cirrhosis.
Novelli
A
A
Istituto di Patologia generale, Università degli Studi di Genova.
Gambella
G R
GR
Anselmo
E
E
Nanni
G
G
D000818:Animals; D001284:Atrophy; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002455:Cell Division; D003135:Common Bile Duct; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000473:pathology; D008026:Ligation; D008105:Liver Cirrhosis, Biliary / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D011374:Progesterone / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D011374:Progesterone; D002251:Carbon Tetrachloride
Modello sperimentale di induzione nel ratto di una cirrosi biliare a rapida evoluzione in cirrosi nodulare periportale.