Brain-derived neurotrophic factor (BDNF): role in neuronal development and survival.
In 1989 Leitbrock et al. reported the full primary structure of brain-derived neurotrophic factor. The messenger RNA for BDNF was found predominantly in the central nervous system, and the sequence of protein indicated its structural relation to NGF. BDNF belongs to a larger family of neurotrophic molecules. It stimulates the neurite outgrowth and supports neuronal survival.
Woźniak
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Department of Anatomy, University Medical Academy, Poznań.
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000166:cytology*
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins