[The ability of extracellular calcium and calcium channel blockers to modify the spontaneous activity of the detrusor muscle. An in-vitro study].
The ultimate mechanism of action for all substances with the ability of modifying the activity of smooth muscle is an increased or decreased intracellular concentration of Ca2+. This report presents an "in vitro" study where the dependency on extracellular Ca2+ for the spontaneous activity of the detrusor muscle was investigated, and also the changes that calcium channel blockers can exert on it. The study concludes that the tonic component of the spontaneous activity depends on the Ca2+ intracellular deposits while the physical activity depends on Ca2+ entry from extracellular space. This entry of Ca2+ from the outside is not inhibited by the action of Ca2+ channel blocking agents.
Server Pastor
G
G
Servicio de Urología, Hospital La Fe, Valencia.
Ruiz Cerdá
J L
JL
Osca García
J M
JM
Salóm Sanvalero
J
J
Jiménez Cruz
J F
JF
D000704:Analysis of Variance; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009529:Nicardipine / Q000494:pharmacology; D010477:Perfusion / Q000379:methods; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014700:Verapamil; D009529:Nicardipine; D002118:Calcium
Capacidad del calcio extracelular y los farmacos bloqueadores de la entrada de calcio para modificar la actividad espontaneo del musculo detrusor. Estudio "in vitro".