[Immunostimulation in heart surgery: thymostimulin. Preliminary data].
The immunodepressive effect of surgical procedures is well known. Immunotherapy with thymic hormones has used a long time to prevent surgical immunitary damage. In cardiac surgery, we can observe a hard immunitary depression caused by the cardiopulmonary bypass (CBP). In this paper we evaluate the response to immunotherapy, with an extractive thymic hormone: thymostimulin at the dosage of 1 mg/kg/day; 20 patients of a group of 40 underwent CBP. Immunological monitoring was obtained with the "multitest CMI", a disposable skin test to evaluate changes of lymphocytes, especially T cells. Results shows a significant increase of response in patients treated with thymostimulin versus control. A larger sample and a deeper immunitary assessment will be provided in the future.
Maccherini
M
M
Istituto di Chirurgia Toracica e Cardiovascolare, Ospedale Le Scotte, Università degli Studi di Siena.
Davoli
G
G
Sani
G
G
Miraldi
F
F
Gotti
G
G
Toscano
M
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host / Q000276:immunology*; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011183:Postoperative Complications / Q000276:immunology* / Q000517:prevention & control*; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D013949:Thymus Extracts; C031407:thymostimulin
Immunostimolanti in cardiochirurgia: timostimolina. Dati preliminari.