title: Funipuncture for evaluation of hematologic and coagulation indices in the surviving twin following co-twin's death.
abstract: OBJECTIVE
  To examine the changes in hematologic and coagulation indices in the surviving twin when the co-twin dies because of the twin-twin transfusion syndrome.
  
  
  METHODS
  Fetal blood was obtained by funipuncture in seven surviving twins upon the death of their co-twins. Five of them were monochorionic. In one case at 32 weeks' gestation, two repeated funipunctures were done in both twins before and in the surviving twin after the death of the co-twin. Fetal blood was examined for blood coagulation factors as well as complete blood counts.
  
  
  RESULTS
  Although coagulation factors were not abnormal, three of the five monochorionic surviving twins had cerebral abnormalities postnatally. The fetal blood profile revealed anemia in the surviving twin, especially in the cases in which funipunctures were performed within 24 hours after the co-twin's death. This demonstrates that acute anemia in the surviving twin was induced by hemorrhage from the larger to the smaller twin at the time of death.
  
  
  CONCLUSIONS
  Following the death of one twin, morbidity in the surviving twin can be produced by hypotensive ischemia of the brain due to hemorrhage through placental vascular anastomoses.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: J
authors.initials: J
authors.lastname: Murotsuki
authors.forename: S
authors.initials: S
authors.lastname: Tanigawara
authors.forename: S
authors.initials: S
authors.lastname: Uehara
authors.forename: A
authors.initials: A
authors.lastname: Yajima
mesh_terms: D001777:Blood Coagulation; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000166:cytology*; D005313:Fetal Death / Q000097:blood*; D005330:Fetofetal Transfusion / Q000097:blood*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D010100:Oxygen / Q000097:blood; D010976:Platelet Count; D011247:Pregnancy; D014427:Twins
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen