title: Early death or retransplantation in adults after orthotopic liver transplantation. Can outcome be predicted?
abstract: Early, reliable outcome prediction after a liver transplant would help improve organ use by minimizing unnecessary retransplantations. At the same time, early intervention in those cases destined to fail may ameliorate the high morbidity and mortality associated with retransplantation. The purpose of this study was to analyze several parameters that have been identified in the past as being associated with patient and graft outcome, and to try to develop a model that would allow us to make predictions based on data available in the early postoperative period. A total of 148 patients were followed in a prospective, observational study. Graft failure was defined as patient death or retransplantation within 3 months of surgery. Preoperative variables studied included patient demographics, need for life support, presence of ascites, serum bilirubin, serum albumin, prothrombin time, serum creatinine, and the results of the cytotoxic crossmatch. During the first 5 postoperative days, standard measurements included serum transaminases, serum bilirubin, ketone body ratio, prothrombin time, factor V, and serum lactate. Oxygen consumption was measured shortly after surgery, once the patients had rewarmed to 36 degrees C. There were 131 successful transplants (88.5%) and 17 failures (11.5%). Most of the variables studied were found to be associated with outcome (by univariate analysis) at different points in the early postoperative period. However, receiver operating characteristic curve analysis showed that the predictive ability of even the best parameter was not adequate to make decisions on individual patients. Multivariate analysis, using stepwise logistic regression, yielded a model with an overall accuracy of 92.7%. Again, receiver operating characteristic curve analysis suggested that this model did not achieve the discriminating power needed for routine clinical use. We are still not able to accurately predict outcome in the early posttransplant period. We must be very careful when evaluating parameters, or scoring systems, that are said to accomplish this. It is especially important in this era of cost containment, with its renewed pressures to guide therapy based on our perceived understanding of a patient's future clinical course.
authors.affiliation: Pittsburgh Transplantation Institute, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: H R
authors.initials: HR
authors.lastname: Doyle
authors.forename: I R
authors.initials: IR
authors.lastname: Marino
authors.forename: N
authors.initials: N
authors.lastname: Jabbour
authors.forename: G
authors.initials: G
authors.lastname: Zetti
authors.forename: J
authors.initials: J
authors.lastname: McMichael
authors.forename: S
authors.initials: S
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Fung
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
mesh_terms: D001663:Bilirubin / Q000097:blood; D003404:Creatinine / Q000097:blood; D005165:Factor V / Q000032:analysis; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D007657:Ketone Bodies / Q000097:blood; D007773:Lactates / Q000097:blood; D016031:Liver Transplantation / Q000276:immunology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011517:Prothrombin Time; D012086:Reoperation; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
chemical_list: D007657:Ketone Bodies; D007773:Lactates; D005165:Factor V; D003404:Creatinine; D000637:Transaminases; D001663:Bilirubin