Tissue lipid quantification using narrow bandwidth magnetic resonance imaging with a presaturation pulse.
OBJECTIVE
Chemical-shift artifact occurs within tissues when band-like presaturation pulses are applied perpendicular to the frequency-encoding axis in narrow band-width magnetic resonance imaging. This phenomenon was used to quantify the lipid fraction in phantoms used to simulate tissue.


METHODS
Twenty phantoms with various lipid/water ratios were imaged on spin-echo sequence (repetition time/echo time, 2,000/20 msec) using a 1.5-T magnet. A narrow bandwidth that caused 6-mm chemical shift and a presaturation pulse 6-mm in width were used in the imagining. The lipid fraction values calculated from the resulting images were compared with values determined by a spectrometer.


RESULTS
The image-derived values (LI) correlated strongly with the values determined by spectrometry (LS) (LI = 0.97 + 0.99 LS, r = .998).


CONCLUSIONS
Chemical-shift artifact around the presaturation-applied areas should provide a simple and efficient method for the accurate quantification of tissue lipid fractions.
Ishizaka
H
H
Department of Diagnostic Radiology, Gunma University Hospital, Japan.
Tomiyoshi
K
K
Matsumoto
M
M
Inoue
T
T
D016477:Artifacts; D006801:Humans; D008055:Lipids; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008961:Models, Structural
D008055:Lipids