Protective effects of the inhibition of the renin-angiotensin system against gastric mucosal lesions induced by cold-restraint in the rat.
Experiments were designed to examine whether inhibition of the renin-angiotensin system alters gastric mucosal damage in conscious rats subjected to restraint. Two hours immobilization resulted in an ulcer index of 46 +/- 4 (n = 16) which was decreased by converting enzyme inhibitor (MK 422, enalaprilat) doses of 1 and 10 mg.kg-1.h-1 by 50 +/- 16 (n = 8) and 66 +/- 8% (n = 13), respectively (p < 0.05). Gastric blood flow measured by both the 99Tc-labelled frog erythrocytes and 86Rb-clearance methods was low in untreated rats and increased to more than three-fold in angiotensin converting enzyme inhibitor treated animals. Infusion of saralasin a specific angiotensin II receptor blocker (5 micrograms.kg-1.h-1, n = 25) also decreased the ulcer index by 40 +/- 5% (p < 0.05). Thus inhibition of the renin-angiotensin system in conscious cold-restraint rat increased gastric blood flow and reduced mucosal damage. These results suggest that the renin-angiotensin system plays a significant role in the development of experimental gastric ulcer in the cold-restraint model.
Ender
F
F
Department of Surgery Schöpf-Merei Hospital, Budapest, Hungary.
Labancz
T
T
Rosivall
L
L
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D003080:Cold Temperature; D015773:Enalaprilat / Q000494:pharmacology; D005753:Gastric Mucosa / Q000098:blood supply / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D012504:Saralasin / Q000494:pharmacology; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D013312:Stress, Physiological
D015773:Enalaprilat; D012504:Saralasin