Experimental study of the osteogenic capacity of periosteal allografts: a preliminary report.
A total of 16 rabbits were used in this investigation. Beijing long-eared white rabbits served as donors and immunologically incompatible Chinchilla rabbits as recipients. Periosteal flaps were stripped from the femurs of 8 donor rabbits and implanted into the muscles of both thighs of 8 recipients. Revascularization of the grafts was done only on the left side. Immunosuppressants were administered orally beginning the day of surgery. The animals were observed for 1-4 months. A series of radiography, histomorphology, fluorochrome labelling, and electron microscopic examinations were performed. The results demonstrated that all of the revascularized periosteal allografts had new bone formation (8/8), while the nonrevascularized periosteal allografts had none (0/8). The difference in the rate of new bone formation between the two groups was statistically significant.
Liu
J Y
JY
Department of Microsurgery, Beijing Ji Shui Tan Hospital, Beijing Institute of Traumatology and Orthopaedics, China.
Wang
D
D
Cheng
H H
HH
D000714:Anastomosis, Surgical; D000818:Animals; D001284:Atrophy; D016723:Bone Remodeling / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods / Q000473:pathology / Q000502:physiology; D002113:Calcification, Physiologic; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D005269:Femur; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009132:Muscles / Q000601:surgery; D010012:Osteogenesis; D010521:Periosteum / Q000098:blood supply / Q000473:pathology / Q000502:physiology* / Q000637:transplantation*; D011817:Rabbits; D013752:Tetracycline; D014184:Transplantation, Homologous; D014654:Vascular Patency
D013752:Tetracycline