[The importance of studying clonogenic properties of medullary hematopoietic cells in multiple myeloma].
The study of clonogenic properties of granulomonocytopoiesis cell-precursors (CFU-GM) in 47 multiple myeloma patients revealed that the lowest clonogenic activity of the bone marrow occurs in the initial stage of multiple myeloma and in the development of the disease relapse. In remission the pool of normal CFU-GM seemed much improved due to suppression of the tumor cell pool by cytostatic drugs. Clonogenic properties of the above cell-precursors may serve a valuable marker of the multiple myeloma treatment efficacy.
Abdulkadyrov
K M
KM
Bessmel'tsev
S S
SS
Balashova
V A
VA
D000328:Adult; D000368:Aged; D002999:Clone Cells / Q000473:pathology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*
O neobkhodimosti izucheniia klonogennykh svoĭstv gemopoéticheskikh kletok kostnogo mozga pri mnozhestvennoĭ mielome.