title: A lymphotoxin-beta-specific receptor.
abstract: Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.
authors.affiliation: Division of Biomedical Sciences, University of California, Riverside 92521.
authors.forename: P D
authors.initials: PD
authors.lastname: Crowe
authors.forename: T L
authors.initials: TL
authors.lastname: VanArsdale
authors.forename: B N
authors.initials: BN
authors.lastname: Walter
authors.forename: C F
authors.initials: CF
authors.lastname: Ware
authors.forename: C
authors.initials: C
authors.lastname: Hession
authors.forename: B
authors.initials: B
authors.lastname: Ehrenfels
authors.forename: J L
authors.initials: JL
authors.lastname: Browning
authors.forename: W S
authors.initials: WS
authors.lastname: Din
authors.forename: R G
authors.initials: RG
authors.lastname: Goodwin
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D003545:Cysteine / Q000737:chemistry; D006801:Humans; D006825:Hybridomas; D008024:Ligands; D053259:Lymphotoxin beta Receptor; D008233:Lymphotoxin-alpha / Q000378:metabolism*; D008969:Molecular Sequence Data; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: C505697:LTBR protein, human; D008024:Ligands; D053259:Lymphotoxin beta Receptor; D008233:Lymphotoxin-alpha; D018124:Receptors, Tumor Necrosis Factor; D011993:Recombinant Fusion Proteins; D014409:Tumor Necrosis Factor-alpha; D003545:Cysteine; D013755:Tetradecanoylphorbol Acetate