title: Poor sensitivity of the fifty-gram one-hour glucose screening test for hyperglycemia.
abstract: To determine the sensitivity and specificity of the 50-g 1-h glucose screening test (GST) for hyperglycemia established in a home-monitored glucose profile (HGP) from blood sampled 1 h after each of the main meals on the following day, we prospectively studied 415 pregnant women at increased risk for gestational diabetes and compared 1 GST with 1 HGP. At the commonly recommended GST threshold of 7.8 mmol/l and an HGP threshold of 7.0 mmol/l, the sensitivity of the GST was 27%, the specificity 89%, and the likelihood ratio for a positive test 2.4. Therefore, we conclude that the 50-g 1-h glucose screening test discriminates poorly between pregnant women with and without postprandial hyperglycemia.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, Erasmus University, Rotterdam, Netherlands.
authors.forename: H E
authors.initials: HE
authors.lastname: van Turnhout
authors.forename: F K
authors.initials: FK
authors.lastname: Lotgering
authors.forename: H C
authors.initials: HC
authors.lastname: Wallenburg
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data*; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis*; D011247:Pregnancy; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D001786:Blood Glucose; D005947:Glucose