title: Pulmonary autograft replacement of the aortic valve in the potential parent.
abstract: Aortic valve replacement in the child and young adult is often delayed, and multiple operations or invasive procedures are performed to avoid valve replacements. Prosthetic valves, bioprosthetic valves, or allograft valves have been associated with significant complications or early failure and have been a disappointing solution for the patient requiring aortic valve replacement. The pulmonary autograft replacement (PAR) of the aortic valve in children has been shown to be safe and effective with a low incidence of late valve dysfunction. The absence of thromboembolism, the avoidance of anticoagulants, and its viability with the potential for growth and repair strongly support its use for the potential parent, patients of age 35 or less. The experience with 112 patients, 32 females and 80 males, ages 1.5 to 35 years (average 16.1) are reviewed. Twenty-four had aortic insufficiency, 34 had aortic stenosis, and 54 had both aortic stenosis and insufficiency. Actuarial survival was 95.4% +/- 2.0% at 7 years and freedom from reoperation or significant aortic insufficiency of the autograft valve was 92.7% +/- 3.7%. Freedom from all valve related complications of the autograft valve and the homograft replacement of the pulmonary valve was 90.0% +/- 4.0%. Reoperation for the autograft valve was related to limited experience in one, leaflet prolapse and adherence to a VSD patch in one, associated lupus erythematosus in one, and annular and sinotubular dilatation in one. Reoperation of the homograft valve in two patients was secondary to early homograft stenosis, probably due to rejection.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
authors.forename: R C
authors.initials: RC
authors.lastname: Elkins
authors.forename: C J
authors.initials: CJ
authors.lastname: Knott-Craig
authors.forename: J D
authors.initials: JD
authors.lastname: Razook
authors.forename: K E
authors.initials: KE
authors.lastname: Ward
authors.forename: E D
authors.initials: ED
authors.lastname: Overholt
authors.forename: M M
authors.initials: MM
authors.lastname: Lane
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000209:etiology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000254:growth & development / Q000503:physiopathology / Q000637:transplantation*; D012086:Reoperation; D015996:Survival Rate; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000379:methods