title: Localization of glucose-dependent insulinotropic polypeptide (GIP) to a gene cluster on chromosome 17q.
abstract: Glucose-dependent insulinotropic polypeptide (GIP) has been regionally localized to a gene cluster on human chromosome 17q. Genetic mapping through CEPH reference families demonstrated that GIP was tightly linked to NME1 and PPY and fully linked to HOXB6 and NGFR. High-resolution radiation hybrid mapping resolved the gene order as cen-PPY-HOXB6-NGFR-GIP-NME1-tel. GIP maps distal to NGFR with an estimated distance of 250 kb.
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
authors.forename: T B
authors.initials: TB
authors.lastname: Lewis
authors.forename: M
authors.initials: M
authors.lastname: Saenz
authors.forename: P
authors.initials: P
authors.lastname: O'Connell
authors.forename: R J
authors.initials: RJ
authors.lastname: Leach
mesh_terms: D000818:Animals; D016466:CHO Cells; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D005749:Gastric Inhibitory Polypeptide / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects; D008126:Lod Score; D005810:Multigene Family; D051381:Rats
chemical_list: D005749:Gastric Inhibitory Polypeptide