Demonstration of the high-affinity IgE receptor (Fc epsilon RI) on Langerhans cells of oral mucosa.
Langerhans cells in the skin have recently been shown to bind IgE molecules via a high-affinity IgE receptor. Using two specific antibodies, 29C6 and 6F7, against the alpha-chain of the high-affinity IgE receptor, we here demonstrate that Langerhans cells express this receptor in oral mucosa. A specific antibody, Tü1, against the low-affinity IgE receptor showed only low expression of this receptor. High-affinity binding for IgE may be important for induction and support of Langerhans cell-dependent transepithelial IgE-mediated allergic reactions and inflammation.
Haas
N
N
Department of Dermatology, Rudolf Virchow Hospital, Free University of Berlin, Germany.
Hamann
K
K
Grabbe
J
J
Czarnetzki
B M
BM
D000911:Antibodies, Monoclonal / Q000276:immunology; D002452:Cell Count; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D007801:Langerhans Cells / Q000378:metabolism*; D009061:Mouth Mucosa / Q000166:cytology / Q000276:immunology*; D011485:Protein Binding; D017455:Receptors, IgE / Q000145:classification / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D017455:Receptors, IgE; D007073:Immunoglobulin E