Hyposomatomedinemia and hypogonadism in hemiplegic men who live in nursing homes.
The purpose of this study was to determine the prevalence of low serum insulin-like growth factor-I (IGF-I) and testosterone in men with poststroke hemiplegia. Serum concentrations of IGF-I, total testosterone, and free testosterone were compared in healthy young men, healthy old men, and old men with poststroke hemiplegia. A low IGF-I level, below the lower 2.5 percentile of the healthy young men, occurred in 85% of the healthy old men, and in 88% of the poststroke hemiplegic patients. When a low IGF-I was defined as a value below the lower 2.5 percentile of the healthy old men, the prevalence in the hemiplegic men was 5%. For total testosterone, a value below the lower 2.5 percentile in the healthy young men occurred in 78% of the healthy old men and in 79% of the stroke survivors. Low total testosterone, defined as a value below the lower 2.5 percentile of the healthy old men, occurred in 17% of the hemiplegic men. The results with free testosterone were similar. Compared with healthy young men, most healthy old men have low serum IGF-I and testosterone levels. Old hemiplegic men resemble healthy old men in their IGF-I levels, but they have more cases of severe hypogonadism (total tostosterone < 193ng/dL). Because correction of IGF-I and testosterone deficiencies in younger adults improves muscle strength, work capacity, and quality of life, treatment with human growth hormone and testosterone may be a useful adjunct to physical measures in the rehabilitation of selected hemiplegic stroke survivors.
Abbasi
A
A
Department of Medicine, Medical College of Wisconsin, Milwaukee.
Mattson
D E
DE
Cuisinier
M
M
Schultz
S
S
Rudman
I
I
Drinka
P
P
Rudman
D
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D006429:Hemiplegia / Q000097:blood* / Q000534:rehabilitation; D006801:Humans; D007006:Hypogonadism / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000172:deficiency / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use
D013739:Testosterone; D007334:Insulin-Like Growth Factor I