title: Evaluation of retinoids as therapeutic agents in dermatology.
abstract: Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.
authors.affiliation: Research Triangle Institute, Research Triangle Park, North Carolina 27709.
authors.forename: A H
authors.initials: AH
authors.lastname: Lewin
authors.forename: M E
authors.initials: ME
authors.lastname: Bos
authors.forename: F C
authors.initials: FC
authors.lastname: Zusi
authors.forename: X
authors.initials: X
authors.lastname: Nair
authors.forename: G
authors.initials: G
authors.lastname: Whiting
authors.forename: P
authors.initials: P
authors.lastname: Bouquin
authors.forename: G
authors.initials: G
authors.lastname: Tetrault
authors.forename: F I
authors.initials: FI
authors.lastname: Carroll
mesh_terms: D000287:Administration, Topical; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006986:Hypervitaminosis A / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008812:Mice, Hairless; D011817:Rabbits; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D014212:Tretinoin