title: Intraperitoneal injection of 1-oleoyl-2-docosahexaenoyl phosphatidylcholine enhances discriminatory shock avoidance learning in rats.
abstract: Effects of injection of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (ODHPC) on learning ability were investigated in rats using discriminatory shock avoidance learning task. When ODHPC (2 mumol) was intraperitonealy administered 5 min before the beginning of the first trial of learning task from the second to fifth sessions, avoiding rates of the ODHPC-injected group were significantly higher than those of the control group. However, any injection of ODHPC derivatives, such as 1-oleoyl-2-docosahexaenoyl-diacylglycerol, 1,2-dioleoyl-sn-glycero-3-phosphorylcholine, glycerophosphorylcholine, docosahexaenoate, oleate and choline chloride, did not affect learning. These results suggest that intraperitoneal ODHPC injection enhances learning ability by its specific conformation.
authors.affiliation: Department of Physiology, Yamanashi Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Izaki
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: J
authors.initials: J
authors.lastname: Arita
authors.forename: M
authors.initials: M
authors.lastname: Iriki
authors.forename: H
authors.initials: H
authors.lastname: Hibino
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004597:Electroshock; D007274:Injections, Intraperitoneal; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D010446:Peptide Fragments; D010713:Phosphatidylcholines; C084316:1-oleoyl-2-docosahexaenoyl phosphatidylcholine