title: Clozapine treatment of spasmodic torticollis.
abstract: We report a trial of clozapine (CLO) in patients with spasmodic torticollis (ST). In an open-design trial we treated five patients with adult-onset ST with CLO (300 mg/d) over 12 weeks and one patient over 3 weeks. We videotaped the patients three times (before and at the end of CLO treatment, and 2 weeks after CLO withdrawal) according to a standardized protocol. At the end of the treatment period, CLO plasma concentrations ranged from 67 to 371 ng/ml. In all six patients, analysis of the video ratings and patients' self-assessments failed to reveal any improvement of ST. These preliminary results fail to confirm any therapeutic benefit of CLO in the treatment of ST.
authors.affiliation: Department of Psychiatry, University of Göttingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Thiel
authors.forename: D
authors.initials: D
authors.lastname: Dressler
authors.forename: C
authors.initials: C
authors.lastname: Kistel
authors.forename: E
authors.initials: E
authors.lastname: Rüther
mesh_terms: D000328:Adult; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013035:Spasm / Q000188:drug therapy*; D014103:Torticollis / Q000188:drug therapy*
chemical_list: D003024:Clozapine