[The protective properties of the outer membranes of Francisella tularensis in an experimental infection in guinea pigs].
Subcutaneous immunization, made in a single injection, with outer membrane preparations obtained from F.tularensis vaccine strain 15 and virulent strain A'Cole results in intensive immunity to tularemia in guinea pigs, ensuring the protection of 60-100% of the animals within a month after challenge with F.tularensis virulent strain 503 in a dose of 1,000 DCL. The development of protective effect induced by F.tularensis outer membranes can be observed during the first 24 hours and reaches its maximum by days 15-21 after immunization.
Khlebnikov
V S
VS
Golovlev
I R
IR
Chugunov
A M
AM
Zhemchugov
V E
VE
Averin
S F
SF
Afanas'ev
S S
SS
Pshirkov
S Iu
SIu
Konovalov
S I
SI
Stepanov
A V
AV
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D006168:Guinea Pigs; D007114:Immunization; D013997:Time Factors; D014406:Tularemia / Q000401:mortality / Q000517:prevention & control*; D014774:Virulence
D001428:Bacterial Vaccines
Zashchitnye svoĭstva vneshnykh membran Francisella tularensis pri éksperimental'noĭ infektsii morskikh svinok.