Technetium-99m-N,N-ethylenedicysteine--a comparative study of renal scintigraphy with technetium-99m-MAG3 and iodine-131-OIH in patients with obstructive renal disease.
Technetium-99m-labeled N,N-ethylenedicysteine (99mTc-EC) is a new renal imaging agent introduced as an alternative for 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3), with similar renal excretion characteristics. To evaluate the diagnostic characteristics of this agent, a gamma camera study was performed.


METHODS
Sixteen patients with obstructive renal disease and six normal controls were injected with 90 to 110 MBq of 99mTc-EC and 7.4 MBq 131I-labeled orthoiodohippurate (OIH). Serial images were obtained during 20 min for 99mTc-EC and 30 min for OIH. The study was repeated using 90 to 110 MBq 99mTc-MAG3 during the same week.


RESULTS
Renograms, functional ratios and urinary excretion patterns of all three agents were similar. The mean time to peak activity values for OIH, 99mTc-EC and 99mTc-MAG3 were 4.25 +/- 0.37 min, 4.39 +/- 0.32 min and 4.00 +/- 0.24 min, respectively. The time from peak to 50% activity values for OIH, 99mTc-EC and 99mTc-MAG3 were 5.48 +/- 0.80 min, 6.93 +/- 0.69 min and 7.33 +/- 0.85 min, respectively.


CONCLUSIONS
It is concluded that 99mTc-EC has excellent imaging characteristics and similar excretion properties to OIH. The advantages of 99mTc-EC over 99mTc-MAG3 are lower hepatobiliary uptake and simplicity of preparation.
Ozker
K
K
Department of Nuclear Medicine, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
Onsel
C
C
Kabasakal
L
L
Sayman
H B
HB
Uslu
I
I
Bozluolçay
S
S
Cansiz
T
T
Kapicioğlu
T
T
Urgancioğlu
I
I
D000328:Adult; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D017263:Technetium Tc 99m Mertiatide; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging; D014545:Urinary Calculi / Q000000981:diagnostic imaging
D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; C073806:technetium Tc 99m-ethylenedicysteine; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide; D003545:Cysteine