[The enzymes of mono-oxygenase oxidation in the lymphocytes and liver of persons subjected to chlorophenoxy herbicide exposure].
The activity of benzopyrene hydroxylase (cytochrome P-450IA1) was studied in a mitogen-stimulated culture of peripheral blood lymphocytes from residents of the South Vietnam area treated with chlorophenoxy herbicides in the years of American aggression. The population residing in the untreated territory served as the control. The basal and induced benzopyrene hydroxylase activities, as well as the inducibility ratio were determined for each patient using the "lymphocytic test". The content of antipyrine metabolites and their percentage were estimated in the urine of the same patients using the antipyrine test. The computer processing of data allowed to perform primary analysis of the monooxygenase system in lymphocytes by groups in order to reveal correlations between the content of antipyrine metabolites in the urine and the cytochrome P-450IA1 in blood lymphocytes. The effect of residual amount of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) on the human monooxygenase system is discussed.
Ostashevskiĭ
V A
VA
Gerasimov
K E
KE
Tsyrlov
I B
IB
Rumak
V S
VS
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000009:adverse effects*; D015084:2,4-Dichlorophenoxyacetic Acid / Q000009:adverse effects*; D000328:Adult; D000075182:Agent Orange; D000983:Antipyrine; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis / Q000187:drug effects; D003678:Defoliants, Chemical / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010105:Oxygenases / Q000187:drug effects* / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects*; D012424:Rural Population; D014744:Vietnam; D014857:Warfare
D003678:Defoliants, Chemical; D000072317:Polychlorinated Dibenzodioxins; D015084:2,4-Dichlorophenoxyacetic Acid; D000075182:Agent Orange; D015085:2,4,5-Trichlorophenoxyacetic Acid; D010105:Oxygenases; D001579:Benzopyrene Hydroxylase; D000983:Antipyrine
Issledovanie fermentov monooksigenaznogo okisleniia v limfotsitakh i pecheni liudeĭ, podvergavshikhsia vozdeĭstviiu khlorfenoksigerbitsidov.