title: Improvement of gas exchange following endobronchial instillation of an exogenous surfactant in an infant with respiratory failure by postoperative pulmonary haemorrhage.
abstract: We administered surfactant to a 5-month-old infant with respiratory failure due to right pulmonary haemorrhage accompanied by oedema following abdominal surgery. These pathological conditions were probably precipitated by disseminated intravascular coagulation and intra-operative excessive administration of fluids, respectively. Endobronchial instillation of the exogenous surfactant (120 mg) after selective intubation of the right bronchus produced a dramatic improvement of gas exchange 30 min after treatment and of chest X-ray findings at 6 h post-treatment. This case on an infant indicates that administration of surfactant may be one of promising therapeutic approaches to respiratory failure due to pulmonary haemorrhage.
authors.affiliation: Department of Anaesthesiology, Kobe University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mikawa
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Nishina
authors.forename: O
authors.initials: O
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Yaku
authors.forename: H
authors.initials: H
authors.lastname: Obara
mesh_terms: D001656:Biliary Atresia / Q000150:complications / Q000601:surgery; D001688:Biological Products; D001980:Bronchi; D002761:Cholangitis / Q000150:complications / Q000601:surgery; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007322:Instillation, Drug; D008171:Lung Diseases / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D011183:Postoperative Complications / Q000188:drug therapy* / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
chemical_list: D001688:Biological Products; D011663:Pulmonary Surfactants; C072197:beractant