title: ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22.
abstract: The development of type 1 (insulin dependent) diabetes mellitus (IDDM) requires a genetically susceptible host and exposure, early in life, to environmental trigger molecules that induce diabetic autoimmunity to insulin producing islet cells. We previously identified islet cell protein p69 as a candidate autoimmune target in IDDM. Here we describe a human genomic p69 fragment which allowed us to map the gene (ICA1) to chromosome 7p22.
authors.affiliation: Hospital for Sick Children Research Institute, Department of Paediatrics, Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Gaedigk
authors.forename: A M
authors.initials: AM
authors.lastname: Duncan
authors.forename: I
authors.initials: I
authors.lastname: Miyazaki
authors.forename: B H
authors.initials: BH
authors.lastname: Robinson
authors.forename: H M
authors.initials: HM
authors.lastname: Dosch
mesh_terms: D015139:Blotting, Southern; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D004247:DNA / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005091:Exons; D006801:Humans; D017403:In Situ Hybridization; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping
chemical_list: D011506:Proteins; D004247:DNA