Effect of selenite on tumor cell invasiveness.
Pre-exposure of HeLa or NIH:OVCAR-3 cells to selenite resulted in a dose-dependent decrease in the ability of the cells to invade a layer of Matrigel, a reconstituted basement membrane preparation. In contrast, selenate, selenomethionine and sulfite had no significant effect on cell invasiveness. Exposure of HeLa cells to selenite also resulted in a decrease in two of the necessary steps of the invasion process, attachment and mobility; in contrast, exposure of OVCAR cells decreased attachment but not mobility. There was an apparent correlation between the processes that are affected by selenite and those that involve the cellular fibronectin receptor (alpha 5 beta 1 integrin).
Gong
Y
Y
Department of Biological Sciences, Rutgers University, Newark, NJ 07102.
Frenkel
G D
GD
D016475:3T3 Cells; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009361:Neoplasm Invasiveness; D017469:Receptors, Fibronectin / Q000502:physiology; D012645:Selenomethionine / Q000494:pharmacology; D018038:Sodium Selenite / Q000494:pharmacology*; D013447:Sulfites / Q000494:pharmacology
D017469:Receptors, Fibronectin; D013447:Sulfites; D012645:Selenomethionine; D018038:Sodium Selenite