SPf66, a chemically synthesized subunit malaria vaccine, is safe and immunogenic in Tanzanians exposed to intense malaria transmission.
As part of the first trial of the SPf66 malaria vaccine in Africa, three randomized double-blind placebo-controlled studies of SPf66 have been conducted in a highly endemic area of Tanzania. The objectives were to confirm that the product is immunogenic and safe in highly exposed individuals. Results from ten male adult expatriates indicated that the product used in Tanzania is at least as immunogenic as that used in Colombia. No major side-effects were observed in indigenous SPf66 recipients (18 adults, and 25 children aged 1-4 years). Anti-SPf66 antibody titres in all groups showed clear responses to three doses of the vaccine.
Teuscher
T
T
Ifakara Centre and Headquarters, National Institute for Medical Research, Tanzania.
Schellenberg
J R
JR
Bastos de Azevedo
I
I
Hurt
N
N
Smith
T
T
Hayes
R
R
Masanja
H
H
Silva
Y
Y
Lopez
M C
MC
Kitua
A
A
D000293:Adolescent; D000328:Adult; D000818:Animals; D002675:Child, Preschool; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D017780:Malaria Vaccines / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000009:adverse effects* / Q000276:immunology*; D011994:Recombinant Proteins; D013636:Tanzania; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology
D017780:Malaria Vaccines; D015800:Protozoan Proteins; D011994:Recombinant Proteins; C066269:SPf66 protein, Plasmodium; D014614:Vaccines, Synthetic