[Reactivity differences between serums of patients infected with HIV-2 and HIV-1 antigens according to the patients' geographic origin].
We tested 98 sera from HIV-2-infected patients for cross-reactivity with HIV-1 antigens in a competitive EIA test and western blotting. The sera were obtained during epidemiological surveys in Cape Verde Islands (n = 47) and Mali (n = 51). There were significantly more cross reactions with sera from Mali. Similar results were obtained with sera from African patients resident in France. Samples from HIV-2-infected patients from Burkina Faso, Ghana, Ivory Coast and Mali were more often reactive with HIV-1 antigens than were those from HIV-2-infected patients from the western Atlantic coast (Cape Verde, Guinea Bissau and Senegal). These data underline the importance of using specific tests for HIV-2 sero-positivity, and the need to include a panel of HIV-2-positive sera of different geographic origins in quality control kits.
Simon
F
F
Laboratoire de virologie, Hôpital Bichat-Claude Bernard, Paris, France.
Loussert-Ajaka
I
I
Collin
G
G
Gamba
E
E
Powell-Smith
A
A
Gadelle
S
S
Brun-Vézinet
F
F
D000349:Africa / Q000208:ethnology; D015153:Blotting, Western; D003429:Cross Reactions; D005602:France / Q000453:epidemiology; D015488:HIV Antigens / Q000276:immunology*; D015658:HIV Infections / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008302:Mali / Q000453:epidemiology; D011159:Population Surveillance; D015531:Radioimmunoprecipitation Assay; D016036:Seroepidemiologic Studies
D015488:HIV Antigens
Différence de réactivité des sérums de patients infectés par le VIH-2 sur les antigénes VIH-1 en fonction de leur origine géographique.