Prevention of allergic sensitization to beta-lactoglobulin with conjugates made of beta-lactoglobulin coupled to isologous immunoglobulin G.
We have shown that, under certain conditions, a single dose of a conjugate of beta-lactoglobulin linked to isologous IgG suppresses specific antibody responses (IgE, IgG, and IgA) in rats immunized with beta-lactoglobulin. This suppression is allergen specific. It also appears to be effective when animals are first immunized and then tolerized. In addition, administration of the beta-lactoglobulin-IgG tolerogen abolishes mast cell mediator release. This has been shown both in vivo and with passively sensitized mast cells in vitro. We propose that the construction of a tolerogen made of whole protein allergen linked to IgG could provide a novel specific therapy for allergic reactions.
Fritsché
R
R
Nestlé Research Centre, Lausanne, Switzerland.
Borel
Y
Y
D000818:Animals; D003432:Cross-Linking Reagents; D007108:Immune Tolerance / Q000276:immunology*; D007114:Immunization; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D007275:Injections, Intravenous; D007518:Isoantibodies / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D007782:Lactoglobulins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000276:immunology; D016269:Milk Hypersensitivity / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003432:Cross-Linking Reagents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007518:Isoantibodies; D007782:Lactoglobulins; D007073:Immunoglobulin E