title: [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain].
abstract: The article contains data concerning the application of marine products in medical and prophylactic purposes for treatment of various diseases. A specific role is assigned to marine metabolites, such as eicosapentaenic acid (EPA) and docosahexaenic W-3 acid (DHA). It was proved that systematic administration of EPA-DHA (as medication or as accessory food substances) could prevent the development of thrombosis, atherosclerotic lesions of vessels, and activate regional blood microcirculation. As for clinical aspect the most important medical features of EPA-DHA are the following: inhibition of thrombogenic substances liberated from blood plates (including thromboxane A2, thromboglobulin, serotonin, ADF, arachidonic acid, etc); reduction of adhesivity and aggregation of thrombocytes, monocytes, and neutrocytes to vascular wall; capability to activate the synthesis of prostacyclin substances and normalize the disorders of the lipid exchange; strong inhibition of biogenesis of 4-series leukotrienes-potent vasoconstrictors. The article contains practical recommendations concerning administration of marine products, methods of their conditioning, and also medical and prophylactic dosage of EPA-DHA.
authors.forename: V A
authors.initials: VA
authors.lastname: Ter-Karapetian
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000517:prevention & control*; D004281:Docosahexaenoic Acids / Q000627:therapeutic use; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use; D006801:Humans; D008386:Marine Biology; D010936:Plant Extracts / Q000627:therapeutic use*; D014020:Tissue Extracts / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts; D014020:Tissue Extracts; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
vernacular_title: Ob ispol'zovanii morskikh produktov v profilaktike i lechenii zabolevaniĭ sosudov serdtsa i mozga.