Discordant reaction of Leu4 and rabbit anti-human CD3 epsilon in sinonasal 'T'-cell lymphoma.
Twelve cases of sinonasal 'T'-cell lymphoma were studied immunohistologically with a panel of antibodies that included two antibodies to CD3, Leu4 and rabbit anti-human CD3 epsilon. Leu4 was positive in five cases, whereas rabbit anti-human CD3 epsilon was positive in 11. This discordant reaction of the antibodies, suggestive of cytoplasmic CD3 epsilon +, CD3 delta-, and CD3 gamma-, has recently been demonstrated in activated adult natural killer (NK) cells also. Leu4-negative cases had the phenotype CD2+, CD5-, CD7+/-, T-cell receptor (TCR)-, and NK cell markers+, and had non-rearranged TCR genes. These findings suggest that a large group of sinonasal 'T'-cell lymphomas is derived from NK cells.
Yamaguchi
M
M
Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Ohno
T
T
Oka
K
K
Nishii
K
K
Kawakami
K
K
Miwa
H
H
Kita
K
K
Shirakawa
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000943:Antigens, Differentiation / Q000276:immunology*; D017252:CD3 Complex / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000276:immunology*; D011817:Rabbits
D000912:Antibodies, Neoplasm; D000943:Antigens, Differentiation; D017252:CD3 Complex