title: Fentanyl pre-treatment does not affect the pharmacokinetic profile of an induction dose of propofol in adults.
abstract: The initial disposition of propofol was reported to change when the administration was preceded by fentanyl. The pharmacokinetic profile of the induction dose of propofol (2 mg kg-1 body weight) was studied in 20 ASA I patients randomly allocated to receive fentanyl 1.5 microgram kg-1 (n = 12) or not (n = 8). Anaesthesia was maintained with isoflurane in N2O/O2. Venous blood drawn from the contralateral arm was used to determine whole blood propofol concentrations. The mean propofol blood concentrations were comparable in the two groups and were best fitted by a three exponential equation in all the patients, conforming to a three-compartment open mammillary model. Distributions (T1/2 alpha) redistribution (T1/2(7)) and elimination (T1/2 beta half-lives were comparable in the groups, without significant differences in the total body clearance in the area under the time-concentration curve (zero-infinity) in the volume of distribution at steady-state, in the volume of distribution during the elimination phase or in the mean resident time. Our data support the conclusion that pretreatment with fentanyl does not affect the pharmacokinetic profile of the induction dose of propofol in ASA I patients.
authors.affiliation: II Servizio di Anestesia, Ospedale Niguarda Ca' Granda, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Gasperi
authors.forename: A
authors.initials: A
authors.lastname: Cristalli
authors.forename: L
authors.initials: L
authors.lastname: Noé
authors.forename: D
authors.initials: D
authors.lastname: Sabbadini
authors.forename: E
authors.initials: E
authors.lastname: Mazza
authors.forename: M
authors.initials: M
authors.lastname: Prosperi
authors.forename: G
authors.initials: G
authors.lastname: Fantini
authors.forename: A M
authors.initials: AM
authors.lastname: Crespi
authors.forename: S
authors.initials: S
authors.lastname: Rezzani
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D005283:Fentanyl; D015742:Propofol