title: Partial hepatic resection for ischemic graft damage after liver transplantation: a graft-saving option?
abstract: BACKGROUND
  Intrahepatic biliary strictures or parenchymal infarcts may occur after liver transplantation as a complication of ischemic damage to the graft. In some selected cases the lesions appear to be confined to a part of the liver. We report our experience with partial graft resection in this setting.
  
  
  METHODS
  From January 1984 to December 1991, 286 liver transplantations were performed in 257 recipients. Seven patients, three children and four adults, underwent partial hepatectomy 3 to 218 weeks after liver transplantation of a full-size graft. The clinical presentation included septic parenchymal infarcts (n = 4) and nonanastomotic biliary strictures (n = 3) complicating (n = 5) artery thrombosis or not (n = 2). There were four left hepatectomies, two left lobectomies, and one right hepatectomy. In four instances partial hepatectomy was performed after failed attempt at biliary reconstruction (n = 2) or arterial revascularization (n = 2). Partial graft resection was performed extrafascially without Pringle's maneuver and mobilization of the remnant liver to preserve its vascularization.
  
  
  RESULTS
  No surgical complications occurred, and none of the patients experienced acute hepatic failure during the postoperative period. All patients were discharged home 10 to 96 days (median, 23 days) after liver resection. Two patients had recurrent ischemic cholangitis. One patient underwent successful regrafting for recurrent Budd-Chiari syndrome; one patient died of tumor recurrence. Six patients were alive with a follow-up ranging from 12 to 45 months.
  
  
  CONCLUSIONS
  These results suggest that partial graft resection is a safe and graft-saving option after liver transplantation in selected patients with localized ischemic damage of the graft.
authors.affiliation: Department of Surgery, Cochin University Hospital, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Dousset
authors.forename: F
authors.initials: F
authors.lastname: Filipponi
authors.forename: O
authors.initials: O
authors.lastname: Soubrane
authors.forename: O
authors.initials: O
authors.lastname: Boillot
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: Y
authors.initials: Y
authors.lastname: Chapuis
mesh_terms: D000328:Adult; D002675:Child, Preschool; D002761:Cholangitis / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007511:Ischemia / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000601:surgery; D012008:Recurrence