title: Antineoplastic and antiviral activities of podophyllotoxin related lignans.
abstract: 28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1 microM; deoxypodophyllotoxin (1) being the most potent compound in all cases.
authors.affiliation: Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Salamanca, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gordaliza
authors.forename: M A
authors.initials: MA
authors.lastname: Castro
authors.forename: M D
authors.initials: MD
authors.lastname: García-Grávalos
authors.forename: P
authors.initials: P
authors.lastname: Ruiz
authors.forename: J M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D000882:Haplorhini; D006801:Humans; D051379:Mice; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014780:Viruses / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D011034:Podophyllotoxin