Chronic salicylate intoxication and rhabdomyolysis in a patient with scleroderma and Sjögren's syndrome.
A 44-year-old woman with scleroderma and Sjögren's syndrome developed altered consciousness, acute renal failure, and rhabdomyolysis. She had no history of trauma, seizures, alcohol abuse, hyperthermia, or other possible causative factors for rhabdomyolysis. A high serum salicylate level indicated a diagnosis of salicylate intoxication. Medical history after recovery revealed chronic salicylate ingestion for severe headaches. This is possibly the first reported case of rhabdomyolysis caused by chronic salicylate intoxication. Continuous hemodiafiltration early in hospitalization was an effective treatment.
Nawata
Y
Y
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Kagami
M
M
Nakajima
H
H
Matsumura
R
R
Sugiyama
T
T
Sueishi
M
M
Hirasawa
H
H
Iwamoto
I
I
Yoshida
S
S
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D012206:Rhabdomyolysis / Q000209:etiology* / Q000628:therapy; D012459:Salicylates / Q000009:adverse effects*; D020156:Salicylic Acid; D012595:Scleroderma, Systemic / Q000150:complications*; D012859:Sjogren's Syndrome / Q000150:complications*; D014474:Unconsciousness / Q000209:etiology
D012459:Salicylates; D020156:Salicylic Acid