title: Factors affecting compliance with preventive treatment for tuberculosis at Mistassini Lake, Quebec, Canada.
abstract: Non-compliance is the most important cause of failure of anti-tuberculous therapy throughout the world. In 1990 and 1991, an outbreak of tuberculosis occurred on the Mistassini Cree territory in Northern Quebec, Canada, and a number of cases of active tuberculosis occurred among known tuberculin-positive contacts who were non-compliant with preventive therapy. To better understand the factors affecting compliance with preventive treatment, a review of patients prescribed preventive treatment over the past 10 y was conducted. A freely-translated, interviewer-administered questionnaire was used to measure personal/lifestyle factors and knowledge/attitudes about tuberculosis. Clinic dossiers were reviewed to assess compliance. One hundred and two (102) subjects prescribed preventive treatment between 1981 and 1991 were interviewed, of whom 33.7% were judged to have been compliant. The most significant factor associated with compliance with preventive therapy was year of therapy. Between 1981 and 1985, 78% completed treatment, compared to less than 20% since 1986 (p < .0001). The major factor identified as associated with this sudden change was a shift in responsibility for tuberculosis treatment follow-up from native community health workers to non-native nurses in 1985/86. We conclude that tuberculosis control programs must be tailored to take into account the importance of cultural factors in promoting compliance with therapy.
authors.affiliation: Montreal Chest Hospital, McGill University, Quebec.
authors.forename: M
authors.initials: M
authors.lastname: Rideout
authors.forename: R
authors.initials: R
authors.lastname: Menzies
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D003469:Culture; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007198:Indians, North American; D007538:Isoniazid / Q000627:therapeutic use*; D008019:Life Style; D008297:Male; D010349:Patient Compliance; D011792:Quebec; D011795:Surveys and Questionnaires; D014376:Tuberculosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D007538:Isoniazid