title: Immune regulation: a new role for the CD8+ T cell.
abstract: During an immune response, peripheral T cells develop into functionally distinct subpopulations that effect cell-mediated immunity and regulate humoral immune responses through the secretion of specific cytokines. Recent data suggest that CD8+ T cells, which have long been regarded simply as cytotoxic cells, play a more active role in the regulation of the immune response. In this article, Mike Kemeny and colleagues suggest that there are functionally distinct subsets of CD8+ T cells that produce different combinations of cytokines and appear to play an important part in determining the pattern of cytokines produced by CD4+ T cells and the isotype of immunoglobulins expressed by B cells.
authors.affiliation: Dept of Allergy and Allied Respiratory Disorders, United Medical School of Guy's Hospital, London, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Kemeny
authors.forename: A
authors.initials: A
authors.lastname: Noble
authors.forename: B J
authors.initials: BJ
authors.lastname: Holmes
authors.forename: D
authors.initials: D
authors.lastname: Diaz-Sanchez
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000502:physiology*; D002454:Cell Differentiation / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000502:physiology*
chemical_list: D016827:CD8 Antigens; D007073:Immunoglobulin E