Imaging sequence space.
Digital imaging spectrophotometers can simultaneously measure the spectra of hundreds of features in a two-dimensional scene. While a variety of applications can be anticipated, a colorimetric analysis of mutants expressing pigmented proteins has already led to the development of efficient algorithms for optimizing combinatorial mutagenesis.
Youvan
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Palo Alto Institute for Molecular Medicine, Mountain View, California 94043.
D000465:Algorithms; D000906:Antibodies / Q000737:chemistry / Q000235:genetics; D001429:Bacteriochlorophylls / Q000737:chemistry / Q000235:genetics; D007091:Image Processing, Computer-Assisted; D016296:Mutagenesis; D016354:Rhodobacter capsulatus / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods*
D000906:Antibodies; D001429:Bacteriochlorophylls