title: [Failure of empirical treatment with ceftriaxone in motor neuron disease].
abstract: We describe two patients with lateral amyotrophic sclerosis who, after informed consent, received empirical treatment with intravenous cephtriaxone at a dose of 2 g/24 hours for three weeks, with no positive results. The pharmacokinetics of this cephalosporin is analyzed, along with the relationship between motor neuron disease, neuroborreliosis and immunoreactivity to Borrelia burgdorferi.
authors.affiliation: Servicio de Neurología, Hospital Miguel Servet, Zaragoza.
authors.forename: F J
authors.initials: FJ
authors.lastname: Carod Artal
authors.forename: I
authors.initials: I
authors.lastname: Pérez López-Fraile
authors.forename: M
authors.initials: M
authors.lastname: Gracia Naya
authors.forename: J A
authors.initials: JA
authors.lastname: Girón Mombiela
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D001899:Borrelia Infections / Q000188:drug therapy / Q000276:immunology; D015748:Borrelia burgdorferi Group / Q000187:drug effects / Q000302:isolation & purification; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004576:Electromyography; D004584:Electronystagmography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D002443:Ceftriaxone
vernacular_title: Fracaso del tratamiento empírico con ceftriaxona en la enfermedad de la motoneurona.