Evaluation of retinoids as therapeutic agents in dermatology.
Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.
Lewin
A H
AH
Research Triangle Institute, Research Triangle Park, North Carolina 27709.
Bos
M E
ME
Zusi
F C
FC
Nair
X
X
Whiting
G
G
Bouquin
P
P
Tetrault
G
G
Carroll
F I
FI
D000287:Administration, Topical; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006986:Hypervitaminosis A / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008812:Mice, Hairless; D011817:Rabbits; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity
D014212:Tretinoin