title: Clinical evaluation of a new hollow fibre membrane oxygenator.
abstract: Twelve consecutive patients undergoing elective cardiac surgery were perfused with the Cobe Optima hollow fibre oxygenator. Gas transfer characteristics and blood handling were studied. The device had a maximum oxygen transfer of 315 ml/minute. The average shunt fraction was 4.5%, and was not influenced by blood-flow rate. Mean platelet count declined slightly to 91% of the baseline at the end of the study period. Haemolysis was evaluated by monitoring serum-free haemoglobin, serum haptoglobin and serum haemopexin. The evolution was as follows: free haemoglobin increased from 14 +/- 5 mg/100 ml to 85 +/- 0.8/100 ml (p = 0.01) at the end of bypass; haptoglobin decreased from 1.33 +/- 0.90 g/l to 0.89 +/- 0.15 g/l (p = 0.01); and haemopexin decreased from 0.84 +/- 0.13 g/l to 0.74 +/- 0.15 g/l (p = nonsignificant). In all patients the residual capacity of serum haptoglobin to protect against haemolysis was satisfactory. All patients had an uneventful postoperative course.
authors.affiliation: Department of Perfusion, University Hospital Gent, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: De Somer
authors.forename: D
authors.initials: D
authors.lastname: De Smet
authors.forename: M
authors.initials: M
authors.lastname: Vanackere
authors.forename: G
authors.initials: G
authors.lastname: Van Nooten
authors.forename: F
authors.initials: F
authors.lastname: Caes
authors.forename: J
authors.initials: J
authors.lastname: Delanghe
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D005069:Evaluation Studies as Topic; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005260:Female; D006403:Hematologic Tests; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies