Tyrosine ingestion during rat pregnancy alters postnatal development of dopaminergic neurons in the offspring.
It has been previously reported that tyrosine ingestion by the mother rat during gestation modifies different behavioral patterns in the adult offspring. In the present study, the action of maternal mother tyrosine ingestion on the postnatal development of the dopaminergic system of the offspring was evaluated. The offspring of tyrosine-treated mothers showed a decrease in dopamine (DA) levels during the first 15 days of postnatal life and an increase in DA levels from day 30 to adulthood. The DOPAC level and the DOPAC/DA index were higher in the tyrosine group from postnatal life to adulthood. These differences reach statistical significance in both forebrain and mesencephalon. During adulthood the DA concentration in both s. nigra and ventral tegmental area were higher in the tyrosine group than in the control group. The behavioral postsynaptic response to a DA receptor agonist (apomorphine) was higher in the offspring of tyrosine treated rats than in the control group. These data suggest that the bioavailability of the DA precursor tyrosine during gestation may modify during postnatal life DA synapsis at both pre- and postsynaptic level.
Santana
C
C
Department of Physiology, School of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Martin
L
L
Rodriguez Diaz
M
M
D000284:Administration, Oral; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014443:Tyrosine / Q000008:administration & dosage*
D014443:Tyrosine; D004298:Dopamine