Lack of response to corticosteroids and pulse cyclophosphamide therapy in Cogan's syndrome.
A 17-year-old girl with Cogan's syndrome is described. Total and irreversible hearing loss occurred which was unresponsive to corticosteroids and immunosuppressive therapy. The girl died a year later from subarachnoid haemorrhage. The lethal prognosis in Cogan's syndrome despite the available treatment is emphasized.
Vaiopoulos
G
G
Department of Internal Medicine, University of Athens School of Medicine, Laiko General Hospital, Greece.
Sfikakis
P P
PP
Skoumas
B
B
Kavouklis
E
E
Doukas
E
E
Kaklamanis
P
P
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy; D006801:Humans; D007634:Keratitis / Q000188:drug therapy; D013577:Syndrome; D014657:Vasculitis / Q000188:drug therapy*; D015837:Vestibular Diseases / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide