title: Quantification of left-side intracardiac pressures and gradients using mitral and aortic regurgitant velocities by simultaneous left and right catheterization and continuous-wave Doppler echocardiography.
abstract: Noninvasive determination of left-side intracardiac pressures is of clinical importance in many cardiac diseases. To test the reliability and accuracy of left-side intracardiac pressure measurements by continuous-wave Doppler echocardiography, using left-side valvular regurgitations, 47 patients with mitral regurgitation, with or without associated aortic regurgitation, underwent simultaneous Doppler and left and right catheterization. Doppler-derived left atrial and ventricular end-diastolic pressures were respectively estimated by subtracting mitral regurgitant gradient from systolic blood pressure and by diastolic blood pressure minus aortic regurgitant gradient. There were high correlations of mitral (r = 0.961) and aortic regurgitant gradients (r = 0.896) and of left atrial (r = 0.945) and ventricular end-diastolic pressures (r = 0.854) between noninvasive and invasive measurements. Also, agreement analyses showed that there was close agreement between the two technical measurements for each parameter. The present study concluded that continuous-wave Doppler echocardiography provides a reliable and accurate method for the noninvasive evaluation of left-side intracardiac pressures and gradients in patients with mitral and aortic regurgitations.
authors.affiliation: Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Ge
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: D S
authors.initials: DS
authors.lastname: Fan
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: J X
authors.initials: JX
authors.lastname: Fan
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006328:Cardiac Catheterization / Q000379:methods; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012214:Rheumatic Heart Disease / Q000150:complications