Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection.
In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.
Sternberg
J
J
Department of Zoology, University of Aberdeen, Scotland.
Mabbott
N
N
Sutherland
I
I
Liew
F Y
FY
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000502:physiology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000469:parasitology*; D019323:omega-N-Methylarginine
D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester