Neonatal alloimmune thrombocytopenia. A case report and a review of the literature.
A 32-year-old woman in her third pregnancy underwent fetal blood sampling because of a previous child with neonatal thrombocytopenia. At 33 weeks' gestation, fetal thrombocytopenia was diagnosed. Treatment was instituted antenatally with serial fetal platelet transfusions and corticosteroid therapy. Delivery was by Caesarean section at 37 weeks' gestation. Neonatal treatment included further platelet transfusion and immunoglobulin infusion. Recovery of the neonate was complete on discharge from hospital 10 days after birth. The aetiology, diagnosis, clinical presentations and therapeutic options in cases of alloimmune thrombocytopenia are discussed.
Lee
A
A
Royal Women's Hospital, University of Melbourne, Carlton.
Permezel
M
M
Dennington
P
P
Duke
T
T
Doyle
L
L
Robinson
H
H
D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology; D001623:Betamethasone / Q000008:administration & dosage; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D005865:Gestational Age; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D017713:Platelet Transfusion; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy
D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D001623:Betamethasone