Anticardiolipin antibody-associated cerebral infarction in cirrhosis: clearance of anticardiolipin antibody after liver transplantation.
We report a 47-yr-old woman with a 30-yr history of cryptogenic cirrhosis who sustained a cerebral infarction shortly before undergoing liver transplantation. Anticardiolipin antibody titers were positive prior to transplantation (IgG = 24 GPL; IgM > 80 MPL; IgA < 10 APL). After liver transplantation, however, the titers dropped to normal (< 10 PL units). This report suggests that cirrhotic patients with high anticardiolipin antibody titers may be at risk for thrombotic events, and that this tendency may be reversed by liver transplantation or post-transplant immunosuppressive agents.
Talenti
D A
DA
Department of Gastroenterology, Cleveland Clinic Foundation, Ohio.
Falk
G W
GW
Carey
W D
WD
Marchant
K
K
D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D002544:Cerebral Infarction / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008103:Liver Cirrhosis / Q000150:complications / Q000276:immunology* / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged
D017153:Antibodies, Anticardiolipin; D007166:Immunosuppressive Agents