Sclerotic fibroma: a fossil no longer.
We report on a patient with a sclerotic fibroma that recurred 30 months after initial removal. The histologic features were characteristic, and immunoperoxidase stains using primary antibodies directed against cell proliferation markers were positive in a significant proportion of the neoplastic nuclei. A review of the literature identified one other sclerotic fibroma that persisted. These clinical and light microscopic features support the interpretation that sclerotic fibroma is a proliferating neoplasm with an unusual histologic pattern, rather than the end-stage of a process that was formerly more cellular. We advocate use of sclerotic fibroma as the preferred diagnostic term.
McCalmont
T H
TH
Department of Pathology, University of California Medical Center, San Francisco 94143-0506.
D005153:Facial Neoplasms / Q000473:pathology*; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012598:Sclerosis