Complement factor H and related proteins: an expanding family of complement-regulatory proteins?
Recently, several factor-H-related molecules have been identified in humans and mice, initiating new interest in this group of serum proteins. Although no complement-regulatory activity has been demonstrated yet for the human factor-H-related proteins, the immunological and structural similarities to factor H suggest overlapping functions. Here, Peter Zipfel and Christine Skerka review these similarities and suggest a new nomenclature to identify members of the factor-H-related family.
Zipfel
P F
PF
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Skerka
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry* / Q000502:physiology*; D017242:Complement Factor H / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D001798:Blood Proteins; C493495:CFH protein, human; D017242:Complement Factor H