[Reduced erythrocyte glutathione and urinary thioethers in children undergoing treatment with paracetamol].
In the present study the objective was to evaluate whether therapeutic doses of paracetamol in children has an impact on the concentrations of erythrocyte reduced glutathione (GSH) and urinary thioethers (UT), used as indicators of internal exposure to electrophiles, as well as to establish the association between the two parameters. The population sample consisted of 40 children. From each patient, two blood and two urine samples were taken. Sample A was obtained one week after completing treatment and sample B was taken two hours after taking the last dose of paracetamol. The total group was divided into three subgroups according to age: subgroup I from 9 to 8 months, subgroup II from 19 to 72 months and subgroup III from 73 to 132 months. The concentrations of GSH and UT have been determined in blood and urine, respectively. The results demonstrate that after treatment with paracetamol for a period of days (3.57 +/- 0.86) an elevation in GSH was produced in the total group (Z = -2.40, p < 0.05). A significant and positive association (r = 0.52) existed between the GSH and UT values. No correlation was observed either between plasma levels, or the duration of treatment and the effects observed on GSH and UT.
Bernal Ruiz
M L
ML
Departamento de Farmacología, Facultad de Medicina, Universidad de Zaragoza.
Sinues Porta
B
B
Lanuza Giménez
J
J
Gracia Casanova
M
M
Mayayo Dehesa
E
E
Bartolomé Rodríguez
M
M
D000082:Acetaminophen / Q000494:pharmacology* / Q000627:therapeutic use / Q000652:urine; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005334:Fever / Q000188:drug therapy*; D005978:Glutathione / Q000097:blood / Q000378:metabolism / Q000652:urine*; D006801:Humans; D007223:Infant; D008297:Male; D010084:Oxidation-Reduction; D013440:Sulfides / Q000378:metabolism / Q000652:urine
D013440:Sulfides; D000082:Acetaminophen; D005978:Glutathione
Glutation reducido eritrocitario y tioeteres urinarios en niños tratados con paracetamol.