title: The changes in the permeability of the blood-brain barrier when under neurosurgical intervention.
abstract: The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery: 1. Neurosurgical brain trauma did not change the permeability of BBB. 2. Anesthesia resulted in increasing permeability of BBB with peak upon 24-48 h. 3. High blood levels of neurospecific proteins proved protein synthesis in glial cells. 4. Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d. According to the high blood levels of neural proteins, the antigen-antibody reaction took place in blood and autoimmune complexes were eliminated before penetration into the brain. A new mechanism of brain autoimmune safety is discussed.
authors.affiliation: I. M. Sechenov Moscow Medical Academy.
authors.forename: A P
authors.initials: AP
authors.lastname: Khokhlov
authors.forename: I G
authors.initials: IG
authors.lastname: Fetisova
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
authors.forename: V K
authors.initials: VK
authors.lastname: Malakhovsky
mesh_terms: D000328:Adult; D000758:Anesthesia; D000917:Antibody Formation / Q000502:physiology; D000937:Antigen-Antibody Reactions / Q000502:physiology; D015415:Biomarkers; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000601:surgery*; D001930:Brain Injuries / Q000601:surgery; D001932:Brain Neoplasms / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D011184:Postoperative Period
chemical_list: D015415:Biomarkers; D009419:Nerve Tissue Proteins