title: Regulation of intracellular calcium in cardiac muscle.
abstract: We have investigated the regulation of intracellular free calcium in heart muscle using the free acid form of the Ca2+ indicator fura-2 iontophoretically microinjected into rat cardiac trabeculae or ferret papillary muscles. This method shows great promise in elucidating a number of crucial questions in cardiac excitation-contraction coupling.
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD 21205.
authors.forename: P H
authors.initials: PH
authors.lastname: Backx
authors.forename: W D
authors.initials: WD
authors.lastname: Gao
authors.forename: M D
authors.initials: MD
authors.lastname: Azan-Backx
authors.forename: E
authors.initials: E
authors.lastname: Marban
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005289:Ferrets; D016257:Fura-2; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002118:Calcium; D016257:Fura-2