title: Amyloid-P-component-like immunoreactivity in beta/A4-immunoreactive deposits in Alzheimer-type dementia brains.
abstract: An immunohistochemical study using the mirror-image technique was performed in order to establish whether amyloid P component is involved in the mechanism of deposition of amyloid fibrils in senile plaques (SPs) in Alzheimer-type dementia (ATD). Ninety percent of beta/A4 protein-immunoreactive SPs were also stained by the anti-amyloid P component immunohistochemistry, and this applied to all of the diffuse, primitive and classical types of beta/A4 deposits. These findings may suggest an involvement of amyloid P component in the formation of amyloid fibrils in senile plaques in ATD brains.
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Iwamoto
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000032:analysis* / Q000378:metabolism; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D006801:Humans; D011499:Protein Processing, Post-Translational; D000683:Serum Amyloid P-Component / Q000032:analysis*
chemical_list: D016564:Amyloid beta-Protein Precursor; D000683:Serum Amyloid P-Component