CCK8-evoked Ca2+ mobilization in pancreatic acinar cells. Evidence for a regulatory role of protein kinase C by phosphorylation-dependent inhibition of signaling through the high-affinity CCK receptor.
Willems
P H
PH
Department of Biochemistry, University of Nijmegen, The Netherlands.
van Hoof
H J
HJ
van Mackelenbergh
M G
MG
Hoenderop
J G
JG
van Emst-de Vries
S E
SE
De Pont
J J
JJ
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011817:Rabbits; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D012844:Sincalide / Q000031:analogs & derivatives / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D011949:Receptors, Cholecystokinin; C058451:JMV 180; D011493:Protein Kinase C; D012844:Sincalide; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium