title: [Frankfurt shift. 2. The intramolecular of N-oxides of tertiary cycloalkylamines to lactams (Frankfurt shift)].
abstract: The basis knowledge of the Frankfurt shift could be extended by experiments on the kinetic isotopic effect, an experiment with incubation in 18O2-atmosphere and a shift with 1-(4-fluorobenzyl)-piperidine-N-oxide (4). Furthermore the shift was established in a whole animal experiment (rat).
authors.affiliation: Institut für Pharmazeutische Chemie der Johann Wolfgang Goethe-Universität, Frankfurt a.M.
authors.forename: H
authors.initials: H
authors.lastname: Oelschläger
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001711:Biotransformation; D003497:Cyclic N-Oxides / Q000493:pharmacokinetics*; D007769:Lactams / Q000378:metabolism*; D010880:Piperidines / Q000493:pharmacokinetics*; D051381:Rats
chemical_list: C087131:1-(4-fluorobenzyl)piperidine-N-oxide; D003497:Cyclic N-Oxides; D007769:Lactams; D010880:Piperidines
vernacular_title: Weitere Beiträge zur intramolekularen Umlagerung von N-Oxiden tertiärer Cycloalkylamine zu Lactamen (Frankfurt Shift).