Optimal drug and behavior therapy for treatment-refractory schizophrenic patients.
Thirteen treatment-refractory schizophrenic patients (10 men and three women) who were receiving more than 50 mg/day of haloperidol and who had been hospitalized for more than 1 year successfully tolerated a mean dose reduction of 63% with consequent improvement in psychopathology and side effects. The addition of intensive behavior therapy to the optimal dose of haloperidol yielded further improvements in functional behavior, such as self-care and social interaction.
Liberman
R P
RP
Camarillo-UCLA Research Center, Camarillo State Hospital, CA 93011-6022.
Van Putten
T
T
Marshall
B D
BD
Mintz
J
J
Bowen
L
L
Kuehnel
T G
TG
Aravagiri
M
M
Marder
S R
SR
D000328:Adult; D001521:Behavior Therapy; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy*; D012565:Schizophrenic Psychology; D012648:Self Care
D006220:Haloperidol