title: [Anatomo-pathologic diagnostic interpretation of nodular hepatic lesions].
abstract: Thirty cases of primary hepatic carcinomas and twenty hepatic metastatic localizations with equivocal histopathological features were investigated using morphologic criteria and immunohistochemical methods. The study was performed on formalin-fixed, paraffin-embedded tissue sections from surgical removed specimens. On the basis of our experience (in according with literature data) we have shown that most of hepatocellular carcinomas express a specific morphologic pattern (i.e. contemporary cholangiocellular differentiation) and phenotypic characters (particularly CEA positivity with bile canalicular pattern). Nevertheless in some cases it is impossible to make a differential diagnosis; the evaluation of new biological parameters like proliferative index will be useful.
authors.affiliation: Servizio di Anatomia Istologia e Citologia Patologica, Ospedale S. Martino di Genova.
authors.forename: M
authors.initials: M
authors.lastname: Chiaramondia
authors.forename: P
authors.initials: P
authors.lastname: Ceppa
authors.forename: P
authors.initials: P
authors.lastname: Baccini
authors.forename: A
authors.initials: A
authors.lastname: Badini
authors.forename: A
authors.initials: A
authors.lastname: Castellaneta
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D002454:Cell Differentiation; D018281:Cholangiocarcinoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
vernacular_title: Interpretazione diagnostica anatomo-patologica delle lesioni nodulari epatiche.