Glucose oxidase electrodes: effect of hydrogen peroxide on enzyme activity?
This paper presents a simple procedure to assess the amount of hydrogen peroxide arising in amperometric glucose oxidase sensors. At an external glucose concentration of 30 mmol/l, which represents the linear range of calibration, a hydrogen peroxide concentration of approximately 0.18 mmol/l is generated. Taking into consideration that in medical applications the main range of interest would be within euglycaemia which is between 4 and 9 mmol/l, it is concluded that in the type of glucose electrode investigated, hydrogen peroxide produced during enzymatic glucose measurement does not appreciably damage the enzyme glucose oxidase.
von Woedtke
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T
Gerhardt Katsch Institute of Diabetes, University of Greifswald, Karlsburg, Germany.
Fischer
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U
Abel
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P
D015374:Biosensing Techniques; D005949:Glucose Oxidase; D006861:Hydrogen Peroxide / Q000737:chemistry*; D015203:Reproducibility of Results
D006861:Hydrogen Peroxide; D005949:Glucose Oxidase