title: Complete failure of fertilization in couples with mechanical infertility: implications for subsequent in vitro fertilization cycles.
abstract: OBJECTIVE
  To determine whether complete failure of fertilization of oocytes in couples with mechanical infertility during the first IVF cycle indicates a poor prognosis for subsequent IVF cycles.
  
  
  METHODS
  A retrospective study of 172 cycles of IVF in 50 couples with mechanical infertility and complete failure of fertilization during their first IVF trial.
  
  
  METHODS
  In vitro fertilization unit of the Sheba Medical Center.
  
  
  METHODS
  Fifty couples undergoing one to eight cycles of IVF for mechanical infertility.
  
  
  METHODS
  Fertilization rate of retrieved oocytes and pregnancy rate.
  
  
  RESULTS
  Of the initial 50 couples, 44 underwent additional IVF cycles, and 43 (97.7%) achieved fertilization during the second or third cycle. Twenty-four patients conceived during the study period as a result of IVF.
  
  
  CONCLUSIONS
  Complete failure of fertilization in couples with mechanical infertility does not necessarily persist during subsequent IVF cycles. Therefore, at least two more IVF cycles should be attempted before reverting to other therapeutic options. Complete failure of fertilization during the first cycle of IVF in couples with mechanical infertility is accompanied by a good prognosis for subsequent cycles.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Lipitz
authors.forename: J
authors.initials: J
authors.lastname: Rabinovici
authors.forename: M
authors.initials: M
authors.lastname: Goldenberg
authors.forename: D
authors.initials: D
authors.lastname: Bider
authors.forename: J
authors.initials: J
authors.lastname: Dor
authors.forename: S
authors.initials: S
authors.lastname: Mashiach
mesh_terms: D005260:Female; D005306:Fertilization / Q000502:physiology*; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D007248:Infertility, Male / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D009865:Oocytes / Q000502:physiology; D011379:Prognosis; D012189:Retrospective Studies; D017211:Treatment Failure