Idiopathic recurring stupor.
Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.
Tinuper
P
P
Institute of Neurology, University of Bologna, Italy.
Montagna
P
P
Plazzi
G
G
Avoni
P
P
Cerullo
A
A
Cortelli
P
P
Sforza
E
E
Bonetti
E P
EP
Schoch
P
P
Rothstein
J D
JD
D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000097:blood; D003128:Coma / Q000097:blood / Q000503:physiopathology*; D026261:Diazepam Binding Inhibitor; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence
D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor