Cytoprotective effect of prostaglandin E2 and I2 in experimental liver damage.
Cytoprotective effect of prostaglandin E2 and prostacyclin on carbon tetrachloride-induced liver damage was studied in rats. The role of endogenous prostaglandins in hepatic cytoprotection was also evaluated. The study population consisted of 275 rats. The study was carried out in two stages because of using two compounds: PGE2 and PGI2. The activity of the following enzymes in blood and hepatic tissue was measured as a criterion of liver damage: 1. ALAT, 2. AspAT, 3. AP, 4. ChE. The results of the present study show that exogenous prostaglandins protect the liver against toxic effects of CC14. Exogenous prostaglandins play also a therapeutic role in the damaged organ. It is also possible that endogenous prostaglandins perform protective functions. In an experiment in male white Wistar rats protective effect of prostaglandin PGE2 and PGI2 on carbon tetrachloride-induced liver damage was studied. The study was carried out in two stages because of using two different prostaglandins. The present results confirm protective effects of prostaglandins and may help in evaluating hepatic pathology in man.
Kluba-Wojewoda
U
U
Department of Infectious Diseases, Jagellonian University Medical College, Kraków.
D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D015232:Dinoprostone / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology*; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002251:Carbon Tetrachloride; D011464:Epoprostenol; D015232:Dinoprostone