Neutrophil dynamics in abdominal cavity of peritonitic rats treated with antiseptics.
Peritonitis was induced in Wistar rats by intraperitoneal inoculation of pure Escherichia coli. Rats in which 2 ml of 1% povidone iodine had been injected intraperitoneally 5 min after the bacterial challenge, showed a decrease in the neutrophil percentage of the peritoneal cell population during the first hours of peritonitis compared to the control group. When the same experiment was performed with 2 ml of 0.05% chlorhexidine the percentage of neutrophils was superior to the control group in the first hours after bacterial challenge. These results concur with a previous study in which the deleterious effect of povidone iodine and the beneficial effect of chlorhexidine were demonstrated.
Celdrán
A
A
Department of Surgery, Pathology, Hospital La Paz, Universidad Autónoma de Madrid, Spain.
Iñarrea
P
P
Fernández
J
J
Larrocha
C
C
Madero
R
R
D000818:Animals; D002710:Chlorhexidine / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010529:Peritoneal Cavity / Q000166:cytology; D010538:Peritonitis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D011206:Povidone-Iodine / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D011206:Povidone-Iodine; D002710:Chlorhexidine