title: Cerebral blood flow autoregulation in acute intracranial hypertension.
abstract: The present series of experiments was carried out to investigate CBF autoregulation during fixed levels of acute increased intracranial pressure (ICP). Three groups of six rats each, one with normal ICP (8 mmHg), one with moderately increased ICP (30 mmHg), and one with severely increased ICP (50 mmHg), were investigated. ICP was maintained by continuous infusion of lactated Ringer solution into the cisterna magna. Cerebral perfusion pressure (CPP), calculated as mean arterial blood pressure--ICP, was increased by intravenously infused norepinephrine and decreased by controlled bleeding. In all groups the corresponding autoregulation curve included a plateau where CBF was independent of changes in CPP, demonstrating intact autoregulation. However, a significant shift of the lower limit of autoregulation (LL) toward lower CPP levels during severe intracranial hypertension was observed (p < 0.006). In the controls the LL was found at CPP = 73 +/- 6 mmHg, in moderately increased ICP the LL was 59 +/- 4 mmHg, and in severely increased ICP the LL was 51 +/- 4 mmHg. These results indicate that an acute elevation of ICP activates a reserve capacity of cerebral resistance vessels that dilate further below the normal physiological LL to maintain CBF at low levels of CPP.
authors.affiliation: University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Hauerberg
authors.forename: M
authors.initials: M
authors.lastname: Juhler
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D006706:Homeostasis; D007427:Intracranial Pressure; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance