Immunotherapy for Stewart-Treves syndrome. Usefulness of intrapleural administration of tumor-infiltrating lymphocytes against massive pleural effusion caused by metastatic angiosarcoma.
We describe a 56-year-old woman with Stewart-Treves syndrome who had severe dyspnea from a pleural effusion caused by metastatic angiosarcoma in the right lung. Tumor-infiltrating lymphocytes (TIL) in the pleural effusion were cultured and expanded in vitro in the continuous presence of recombinant interleukin 2 with periodic stimulation by CD3 antibody. The expanded TIL were administered intrapleurally seven times at 1- to 4-week intervals in combination with intravenous infusion of recombinant interleukin 2. A panel of T-cell clones was also obtained from TIL. Immunotherapy dramatically improved the patient's dyspnea and pleural effusion. A CD4+ T-cell clone and a CD8+ T-cell clone established from TIL had specific cytotoxicity to the tumor cells.
Furue
M
M
Department of Dermatology, University of Tokyo, Japan.
Yamada
N
N
Takahashi
T
T
Kikuchi
K
K
Tsuchida
T
T
Ishibashi
Y
Y
Kobori
O
O
Ihara
A
A
Kitayama
J
J
Minami
M
M
D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003602:Cytotoxicity, Immunologic; D005260:Female; D006394:Hemangiosarcoma / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007267:Injections; D007275:Injections, Intravenous; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008209:Lymphedema / Q000628:therapy*; D016246:Lymphocytes, Tumor-Infiltrating; D015409:Mastectomy, Radical; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000628:therapy*; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000473:pathology / Q000628:therapy*; D013577:Syndrome
D007376:Interleukin-2