[Effects of beta-carotene on lung cancer].
Beta-carotene at concentration of 6.25 micrograms/ml was shown to inhibit significantly the colony forming efficiency (CFE) of cultured human lung cancer 801 cell line and at 12.5 micrograms/ml was shown to completely inhibit CFE. A 42%-68% (P < 0.01) decrease in spontaneous lung metastasis of LA795 murine pulmonary adenocarcinoma was observed when T739 inbred strain mice were fed a diet with beta-carotene (25mg/100g diet). Ability of DNA and RNA synthesis of lung cancer cells were decreased (P < 0.05) after treating with beta-carotene (25 micrograms/ml) by 24 hours, but the ability for DNA synthesis of human lymphocytes was not effected by the same treatment. Expression of ras oncogene was proved to be inhibited by beta-carotene because the product of ras p21 proteins of cancer cells was decreased after treating by beta-carotene.
Lai
B T
BT
Beijing Thoracic Tumor Research Institute.
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000378:metabolism; D012334:RNA, Neoplasm / Q000096:biosynthesis; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay; D019207:beta Carotene
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D019207:beta Carotene; D002338:Carotenoids; D015689:Oncogene Protein p21(ras)