The determination of non-steroidal antiinflammatory drugs in pharmaceuticals by capillary zone electrophoresis and micellar electrokinetic capillary chromatography.
Ibuprofen, indomethacin, ketoprofen, piroxicam and diclofenac have been quantified in dragees, suspension, suppositories, capsules, injection solutions and tablets by capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatography (MEKC). The experiments were performed without specific sample pretreatment. The reproducibility of the method was investigated. Good quantitation was obtained in short analysis times. CE and MEKC are found to offer a good alternative to conventional HPLC methods.
Donato
M G
MG
Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Belgium.
Baeyens
W
W
van den Bossche
W
W
Sandra
P
P
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002021:Buffers; D002138:Calibration; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002845:Chromatography / Q000379:methods; D004008:Diclofenac / Q000032:analysis; D004304:Dosage Forms; D004586:Electrophoresis; D007052:Ibuprofen / Q000032:analysis; D007213:Indomethacin / Q000032:analysis; D007660:Ketoprofen / Q000032:analysis; D008823:Micelles; D010894:Piroxicam / Q000032:analysis; D012015:Reference Standards; D012044:Regression Analysis; D015203:Reproducibility of Results
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002021:Buffers; D004304:Dosage Forms; D008823:Micelles; D010894:Piroxicam; D004008:Diclofenac; D007660:Ketoprofen; D007052:Ibuprofen; D007213:Indomethacin