Augmentation in cytotoxicity of lymphnode lymphocytes by OK-432.
It has been demonstrated that natural killer (NK) cell activity of lymphnode lymphocytes (LNL) is very low and hardly augmented by interferon. In this study, OK-432 was injected into the gastric cancer mass through endoscopy one week before the operation, through which NK activity of LNL was significantly increased. A single cell assay could divide the OK-432-injected patients into two groups; responder and non-responder. In responders, the increased activity induced by OK-432 was found also in the distal lymphnodes.
Tanaka
N
N
Department of Surgery, Iwakuni National Hospital, Japan.
Gotoh
K
K
Kobayashi
G
G
Gouchi
A
A
Orita
K
K
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010844:Picibanil / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000276:immunology
D000276:Adjuvants, Immunologic; D010844:Picibanil