title: Phase-contrast cine MR imaging of normal aqueductal CSF flow. Effect of aging and relation to CSF void on modulus MR.
abstract: Cine phase-contrast MR imaging was used to study pulsatile CSF flow in the aqueduct in 11 young controls (mean age 30 years) and 9 old controls (mean age 69 years). A high-resolution gradient echo technique and an oblique imaging plane, perpendicular to the aqueduct, was used to avoid volume averaging. Phantom studies confirmed that the technique was accurate. Aqueductal velocity and flux in old controls was higher than in young controls, but the differences were not significant. For all controls together, the averaged peak velocity was 4.2 +/- 1.5 cm/s in rostral and -7.8 +/- 4.9 cm/s in caudal direction; for the flux it was 0.16 +/- 0.10 cm3/s in rostral and -0.29 +/- 0.19 cm3/s in caudal direction. Phase-contrast measurements were significantly related to flow-void on modulus MR images, but not with ventricular size or cortical atrophy. The present technique avoids underestimation of aqueductal flow, and therefore reveals higher aqueductal velocity and flux values than previous studies. Factors other than age or atrophy seem to determine aqueductal CSF flow.
authors.affiliation: Department of Diagnostic Radiology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Barkhof
authors.forename: M
authors.initials: M
authors.lastname: Kouwenhoven
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
authors.forename: M
authors.initials: M
authors.lastname: Sprenger
authors.forename: P
authors.initials: P
authors.lastname: Algra
authors.forename: J
authors.initials: J
authors.lastname: Valk
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002535:Cerebral Aqueduct / Q000033:anatomy & histology / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008961:Models, Structural; D011673:Pulsatile Flow