A new hypothesis about the relationship between free radical reactions and hemorheological properties in vivo.
This paper is concerned with a hypothesis that disturbance of free radical reactions may lead to abnormality of hemorheological properties in vivo, and so the free radicals generated in vivo may damage certain tissue cells indirectly by reducing the supply of oxygen and nutrients to these cells through slowing the circulation of blood. This hypothesis is based on the following evidence: A. We have found that the whole blood viscosity at low shear rate correlates to the lipid peroxidation in the patients suffering from certain cardio- or cerebrovascular diseases, and in dogs during liver ischemia reperfusion or hemorrhagic pancreatitis. B. Reports have shown that several alterations of hemorheological properties may take place as a result of free radical reactions, such as lipid peroxidation. For instance, lipid peroxidation may lead to decrease of deformability of red cells, increase of aggregation of red cells, formation of liquid thrombin, etc. C. We have demonstrated that some alterations of hemorheological properties involve the role of free radicals in rats suffering from intestinal ischemia/reperfusion. As evidence for this conclusion, superoxide dismutase (SOD) used as a specific scavenger of superoxide anion radical (O2-) can significantly prevent the intestinal ischemia/reperfusion induced changes of lipid peroxidation, red cell aggregation, Cassion's viscosity and whole blood viscosity at low shear rate in rats.
Mo
J
J
Fourth Military Medical University, Xi'an, P.R. China.
Fan
J
J
Guo
Z
Z
Hunag
C
C
Yan
B
B
Wang
F
F
Wang
D
D
Sun
S
S
D000818:Animals; D001809:Blood Viscosity / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000097:blood / Q000378:metabolism; D004285:Dogs; D016166:Free Radical Scavengers; D005609:Free Radicals; D006470:Hemorrhage / Q000097:blood / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008954:Models, Biological; D010195:Pancreatitis / Q000097:blood / Q000378:metabolism; D051381:Rats; D015427:Reperfusion Injury / Q000097:blood / Q000378:metabolism
D016166:Free Radical Scavengers; D005609:Free Radicals