Tumor suppressor genes which encode transcriptional repressors: studies on the EGR and Wilms' tumor (WT1) gene products.
The study of the WT1 and EGR-1 transcription factors has provided a molecular paradigm for regulation of a coordinate set of target genes during cell growth and differentiation. The next critical questions that must be addressed are: what are the target genes which are normally regulated by WT1-EGR-1, and how does misregulation of these genes result in tumor formation?
Rauscher
F J
FJ
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
D001483:Base Sequence; D016147:Genes, Tumor Suppressor; D005815:Genetic Code; D006801:Humans; D008969:Molecular Sequence Data; D015513:Oncogene Proteins / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology
D015513:Oncogene Proteins; D012097:Repressor Proteins