Apolipoprotein(a) phenotypes in cardio-cerebrovascular diseases.
We report apolipoprotein(a) (apo(a)) phenotypes of 69 myocardial infarction survivors and 56 stroke patients, and compare them with those of 190 healthy Chinese. The results indicate that the distribution of apo(a) phenotype frequency in cardio-cerebrovascular disease patients is different from those of controls. The frequency of the phenotypes B, S1 and S2 in patients is remarkably higher than those in controls within the same single-band apo(a) phenotype. Moreover, the Lp(a) serum concentrations in CCVD patients are significantly higher than those in controls within the same single-band apo(a) phenotype. The apo(a) phenotype analyses of two pedigrees are shown as a typical autosomal dominant inheritance.
Zhuang
Y
Y
Department of Biochemistry, Nanjing Jinling Hospital, Nanjing University, China.
Li
J
J
Wang
J
J
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000235:genetics* / Q000302:isolation & purification; D053241:Apoprotein(a); D002561:Cerebrovascular Disorders / Q000097:blood* / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D006801:Humans; D017270:Lipoprotein(a); D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
D001053:Apolipoproteins; D017270:Lipoprotein(a); D053241:Apoprotein(a)