title: Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.
authors.affiliation: Dept. Oncology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Peters
authors.forename: G
authors.initials: G
authors.lastname: Codacci-Pisanelli
authors.forename: C L
authors.initials: CL
authors.lastname: van der Wilt
authors.forename: J A
authors.initials: JA
authors.lastname: van Laar
authors.forename: K
authors.initials: K
authors.lastname: Smid
authors.forename: P
authors.initials: P
authors.lastname: Noordhuis
authors.forename: H M
authors.initials: HM
authors.lastname: Pinedo
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000097:blood / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D007263:Infusions, Parenteral; D007274:Injections, Intraperitoneal; D002955:Leucovorin / Q000008:administration & dosage*; D051379:Mice; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
chemical_list: D013940:Thymidylate Synthase; D002955:Leucovorin; D005472:Fluorouracil