Endobronchial mucosal bridges as evidence of residual malignancy.
Three patients who exhibited endobronchial mucosal bridges that formed at the site of tumor regression following chemotherapy for small cell lung carcinoma are presented. Histopathologic examination showed residual malignant cells in 2 of the 3 patients within the submucosal fibrous tissue and an overlying benign epithelium. Although these mucosal bridges were previously thought to represent a complete remission following chemotherapy or radiotherapy for small cell lung carcinoma, they may, in fact, harbor a residual malignancy under the benign mucosa.
Ando
Y
Y
Department of Internal Medicine, Japanese Red Cross, Nagoya First Hospital.
Minami
H
H
Nomura
F
F
Sakai
S
S
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001706:Biopsy; D001980:Bronchi / Q000187:drug effects / Q000473:pathology; D001999:Bronchoscopy; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology*