[Tissue immunity reactions in experimental aspergillosis].
The authors have developed a model of acute and chronic aspergillosis induced by Aspergillus fungi injected intraperitoneally to white mice. Subsequent histological evaluation of the mouse viscera identified 3 phases of tissue immunity reactions: non-specific, characterized by mucosal epithelial proliferation and hypersecretion, lymphoid reaction and development of diffuse alveolitis in the lungs, rapid growth of aspergilla; specific, characterized by pronounced proliferative processes, onset of lymphoid-histiocytic and macrophagal pneumonia, emergence of small thin-wall intraalveolar micetomas, absence of aspergilla growth from homogenates of the internal organs; productive, characterized by formation of granuloma, large aspergillomas in the liver and mesenterium. The course of experimental aspergillosis reflects the process of immunity formation in response to advancing infection.
Epokhin
V V
VV
Zemskova
E S
ES
Dorozhkova
I R
IR
D000818:Animals; D001228:Aspergillosis / Q000276:immunology*; D004195:Disease Models, Animal; D051379:Mice
Tkanevye reaktsii immuniteta pri éksperimentalńom aspergilleze.