Hemangiopericytoma of the tongue in a 12-year-old child: ultrastructural and cytogenetic observations.
We report a case of hemangiopericytoma arising from the tongue of a 12-year-old child. Ultrastructurally, tumor cells revealed discontinuous basal lamina, intermediate-type intercellular junctions, subplasmalemmal thickenings, and smooth muscle-type cytoplasmic filaments. In addition, occasional oligocilia and test tube-like inclusions were observed. Karyotypic analysis of the tumor cells revealed two balanced translocations that have not been reported previously in pediatric solid tumors: one involved chromosomes 1 and 3, t(1;3)(p22;q21), and the other involved chromosomes 7 and 12, t(7;12)(p22;q13). This is the first report of cytogenetic aberrations in a pediatric hemangiopericytoma. Correlation with genetic findings in adult hemangiopericytomas suggests that the chromosome 12q13 rearrangement might be of particular importance.
Perez-Atayde
A R
AR
Department of Pathology, Children's Hospital, Boston, MA 02115.
Kozakewich
H W
HW
McGill
T
T
Fletcher
J A
JA
D002648:Child; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D014062:Tongue Neoplasms / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure*; D014178:Translocation, Genetic