Interleukin-6, neutrophilia and the acute phase protein response in colorectal cancer patients.
White blood cell counts and circulating interleukin-6 concentrations were measured in male colorectal cancer patients with (n = 12) and without (n = 15) evidence of an acute phase protein response. In the group with an acute phase protein response circulating neutrophils were increased whereas serum interleukin-6 concentrations were not. These results suggest that in colorectal cancer patients although an acute phase protein response is associated with neutrophilia, both events can occur independent of circulating interleukin-6 concentrations.
McMillan
D C
DC
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Graham
A F
AF
Smith
J
J
Wotherspoon
H A
HA
Fearon
K C
KC
McArdle
C S
CS
D000368:Aged; D002097:C-Reactive Protein / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils
D015850:Interleukin-6; D002097:C-Reactive Protein