title: Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp.
abstract: Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Shu
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: R R
authors.initials: RR
authors.lastname: Wang
authors.forename: K S
authors.initials: KS
authors.lastname: Lam
authors.forename: S E
authors.initials: SE
authors.lastname: Klohr
authors.forename: K J
authors.initials: KJ
authors.lastname: Volk
authors.forename: D M
authors.initials: DM
authors.lastname: Pirnik
authors.forename: J S
authors.initials: JS
authors.lastname: Wells
authors.forename: P B
authors.initials: PB
authors.lastname: Fernandes
authors.forename: P S
authors.initials: PS
authors.lastname: Patel
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D011090:Polyenes; C087124:manumycin E; C087126:manumycin G; C087125:manumycin F