Can heparin cause adult respiratory distress syndrome by a similar mechanism as heparin-associated thrombocytopenia?
A 62-year-old woman who underwent an aortic valve replacement for severe aortic valve stenosis developed postoperative thrombocytopenia and adult respiratory distress syndrome, simultaneously. Both complications resolved promptly after discontinuing heparin therapy. The presence of a heparin-related antiplatelet antibody was detected by in vitro testing. The time course of clinical events suggests the possibility of a heparin-induced, immune-mediated injury to both the pulmonary vascular endothelium and the platelet membrane as an underlying pathophysiologic mechanism.
Asimacopoulos
P J
PJ
Department of Surgery, Baylor College of Medicine, Houston.
Athanasiadis
I
I
McCarthy
J J
JJ
Shade
R J
RJ
Teague
R B
RB
D000906:Antibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D000906:Antibodies; D006493:Heparin