title: Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners.
abstract: This study determined whether daily supplementation with 600 mg vitamin C would reduce the incidence of symptoms of upper-respiratory-tract (URT) infections after participation in a competitive ultramarathon race (> 42 km). Ultramarathon runners with age-matched controls were randomly divided into placebo and experimental (vitamin C-supplemented) groups. Symptoms of URT infections were monitored for 14 d after the race. Sixty-eight percent of the runners in the placebo group reported the development of symptoms of URT infection after the race; this was significantly more (P < 0.01) than that reported by the vitamin C-supplemented group (33%). The duration and severity of symptoms of URT infections reported in the vitamin C-supplemented nonrunning control group was also significantly less than in the nonrunning control group receiving the placebo (P < 0.05). This study provides evidence that vitamin C supplementation may enhance resistance to the postrace URT infections that occur commonly in competitive ultramarathon runners and may reduce the severity of such infections in those who are sedentary.
authors.affiliation: Division of Physical Education, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: E M
authors.initials: EM
authors.lastname: Peters
authors.forename: J M
authors.initials: JM
authors.lastname: Goetzsche
authors.forename: B
authors.initials: B
authors.lastname: Grobbelaar
authors.forename: T D
authors.initials: TD
authors.lastname: Noakes
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D012420:Running
chemical_list: D001205:Ascorbic Acid