title: Spontaneous splenic rupture as the initial manifestation of acute lymphoblastic leukaemia: immunophenotype and cytogenetics.
abstract: Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the first time the immunophenotype and cytogenetic pattern observed.
authors.affiliation: Department d'Hematologia, Hospital de Sant Pau, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Altès
authors.forename: S
authors.initials: S
authors.lastname: Brunet
authors.forename: C
authors.initials: C
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Soler
authors.forename: R
authors.initials: R
authors.lastname: Ayats
authors.forename: A
authors.initials: A
authors.lastname: Sureda
authors.forename: R
authors.initials: R
authors.lastname: López
authors.forename: A
authors.initials: A
authors.lastname: Domingo
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000276:immunology; D003582:Cytogenetics; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics / Q000276:immunology; D012422:Rupture, Spontaneous; D013156:Splenectomy; D013158:Splenic Diseases / Q000209:etiology*