Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds.
The potential involvement of interleukin-1 (IL-1) in the pathogenesis of experimental rhinovirus colds was examined. Nasal lavages were recovered before and for 5 days after rhinovirus infection from 44 subjects, 22 of whom were randomized to receive prophylaxis with glucocorticoids, while the rest received placebo. Immunoreactive IL-1 beta was significantly increased in subjects who were infected and symptomatic compared with noninfected volunteers or subjects who were infected but asymptomatic. Concentrations of immunoreactive IL-1 beta correlated with levels of kinins and albumin in lavage fluids. Studies of IL-1 bioactivity established that most activity in lavages from infected subjects was IL-1 beta. Glucocorticoid prophylaxis did not inhibit IL-1 production, nor did it significantly affect the symptomatic response to infection or, in a subset of patients, neutrophil infiltration. These data are consistent with the hypothesis that IL-1 could contribute to the pathogenesis of rhinovirus infections.
Proud
D
D
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gwaltney
J M
JM
Hendley
J O
JO
Dinarello
C A
CA
Gillis
S
S
Schleimer
R P
RP
D000293:Adolescent; D000328:Adult; D003139:Common Cold / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism*; D012229:Rhinovirus / Q000276:immunology*
D005938:Glucocorticoids; D007375:Interleukin-1