title: Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6.
abstract: The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor alpha (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. The genes are closely linked, with 0/215 recombinants between Anx4 and Tgfa and 1/215 recombinants between these genes and Egr4. The genes are located approximately 2 cM distal to mnd2, a mouse mutation causing neuromuscular disease. The results demonstrate that mnd2 is located at an internal position within this conserved linkage group.
authors.affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618.
authors.forename: L L
authors.initials: LL
authors.lastname: Barrow
authors.forename: K
authors.initials: K
authors.lastname: Simin
authors.forename: J M
authors.initials: JM
authors.lastname: Jones
authors.forename: D C
authors.initials: DC
authors.lastname: Lee
authors.forename: M H
authors.initials: MH
authors.lastname: Meisler
mesh_terms: D000818:Animals; D017314:Annexin A4 / Q000235:genetics*; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D051379:Mice / Q000235:genetics*; D009468:Neuromuscular Diseases / Q000235:genetics; D011995:Recombination, Genetic; D014157:Transcription Factors / Q000235:genetics*; D016211:Transforming Growth Factor alpha / Q000235:genetics*; D016335:Zinc Fingers
chemical_list: D017314:Annexin A4; D014157:Transcription Factors; D016211:Transforming Growth Factor alpha