[Comparison of human granulocytopoiesis and monocytopoiesis stimulation in vitro with various growth factors: clinical conclusions].
Different combination of human growth factors were checked for their ability to stimulate human granulocyte-monocytopoiesis in vitro. The optimal combination was found to be: Interleukin -3 (IL-3) + Granulocyte--Monocyte Colony Stimulating Factor (GM-CSF) + kit ligand (KL). In protocols concerning treatment of leukopenias with hemopoietic growth factors is should be concerned the use of combination of above listed growth factors. These growth factors could be added separately or in form of fusion proteins. In the future the efficiency of sequential addition of hemopoietic growth factors should be also evaluated.
Ratajczak
M Z
MZ
Instytutu, Centrum Medycyny Doświadczalnej i Klinicznej PAN w Warszawie.
Ratajczak
J
J
Kuczyński
W I
WI
D002478:Cells, Cultured; D006098:Granulocytes / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology* / Q000627:therapeutic use; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D007970:Leukopenia / Q000628:therapy; D009000:Monocytes / Q000502:physiology*; D012016:Reference Values
D006133:Growth Substances
Porównanie stymulacji ludzkiej granulocytopoezy i monopoezy in vitro za pomoca rózych czynników wzrostu: wnioski kliniczne.