title: Modeling methodology for vascular input impedance determination and interpretation.
abstract: The significance of pulse wave reflections in the pulmonary vascular system is elaborated using a new method to determine the broadband frequency response of input impedance up to frequencies of 100 Hz. A simple data model, based on the signal construct of a wavelet, is used to generalize and reconcile the common approaches to vascular frequency response estimation so that an accurate response can be calculated from physiological waveforms. Input impedance interpretation is accomplished using a structural and functional modeling methodology. To identify internal structural system properties, the methodology of inverse scattering is used to relate observed pulse wave echoes in the frequency response to a longitudinal distribution of reflection sites of anatomic significance. To identify functional interactions with pulmonary vascular wave mechanics, a time series analysis methodology is proposed to describe vascular interactions using a generalized principle of superposition. The methods of determination and interpretation are applied to a sample pressure-flow data set from the pulmonary circulation of a lamb experiencing vascular-ventilatory interaction. The example suggests that the frequency response is consistent with a discrete longitudinal distribution of reflection sites that may be affected by the ventilator.
authors.affiliation: Department of Pediatrics, University of California, Davis 95616.
authors.forename: S H
authors.initials: SH
authors.lastname: Bennett
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000502:physiology; D008954:Models, Biological; D011652:Pulmonary Circulation / Q000502:physiology*; D012756:Sheep; D014655:Vascular Resistance / Q000502:physiology*; D014783:Viscosity