[The Na+/K+ cotransporter of the erythrocyte membrane in pregnancy-induced hypertension].
In erythrocytes, the extrusion of a cellular sodium level load is accomplished by the Ouabain-sensitive Na+/K+ pump and by the furosemide-sensitive Na+/K+ cotransport, which operates against the passive sodium permeability. An abnormal low rate of net sodium extrusion by the Na+/K+ cotransport was observed in pre-eclamptic patients. At the molecular level the cotransport abnormality seems to be consecutive to a diminished apparent affinity for intracellular Na+. The normal pregnancy is characterized by a strong increase of Na+/K+ cotransport efflux. No difference could be detected between the passive sodium permeability of erythrocytes from normotensive pregnant patients and from normotensive controls. Pre-eclampsia seems to be associated with a low passive sodium and potassium permeability. The abnormalities of cotransport and red cell deformability in patients with pre-eclampsia might be interpreted as an early sign of impaired microcirculation and increased vascular reactivity.
Ulrich
S
S
Abt. Gynäkologie und Geburtshilfe, Stadtkrankenhaus Rüsselsheim.
von Tempelhoff
G F
GF
Heilmann
L
L
D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D012016:Reference Values; D028021:Sodium-Potassium-Chloride Symporters
D002352:Carrier Proteins; D028021:Sodium-Potassium-Chloride Symporters
Der Na+/K(+)-Cotransport an der Erythrozytenmembran beim Schwangerschaftshochdruck.