title: Rapid infusion of magnesium sulfate obviates need for intubation in status asthmaticus.
abstract: Rapid infusion of intravenous magnesium sulfate (MgSO4) was given to two young adults with impending respiratory failure caused by status asthmaticus. The infusion of 2 g of MgSO4 during a 2-minute period was associated with an immediate, dramatic reversal of their severe bronchospasm. This treatment obviated the need for intubation. Continuous beta 2-agonist therapy was performed simultaneously, taking advantage of the MgSO4-induced bronchodilation to deliver the beta 2-agonist to the target tissues. Rapid infusion of intravenous MgSO4 has been documented as safe in standard obstetric literature. Previous reports of MgSO4 therapy for acute asthma have used slow infusion. This is the first report of rapid infusion of MgSO4 for the emergency department management of asthma. In both cases, this therapy obviated the need for endotracheal intubation and mechanical ventilation.
authors.affiliation: Joint Military Medical Centers, Wilford Hall Medical Center, Brooke Army Medical Center, San Antonio, TX 78236.
authors.forename: R P
authors.initials: RP
authors.lastname: Schiermeyer
authors.forename: J A
authors.initials: JA
authors.lastname: Finkelstein
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006024:Glycopyrrolate / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008297:Male; D012131:Respiratory Insufficiency / Q000209:etiology*; D013224:Status Asthmaticus / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D008278:Magnesium Sulfate; D000420:Albuterol; D006024:Glycopyrrolate