[Dosimetry and radiation dose distribution in tumors for radioimmunotherapy: the effect of tumor size].
For aiding to optimize the efficiency of radio-immunotherapy with beta-emitter-labeled monoclonal antibody (MAb), radiation absorbed dose in a small tumor was calculated using a mathematical model for 67Cu, 90Y, 131I, 186Re, and 188Re. MAb distributions were assumed to be uniform or exponential to investigate the tumor size effect on absorbed dose. The salient results are 1) with longer range beta-emitters, radiation absorbed dose is increased with the tumor size increases and the fraction of radiation dose to the outside of the tumor is large; 2) with shorter range beta-emitters, the tumor size effect on absorbed dose is small. The fraction of radiation dose to the tumor is large and small tumors will be irradiated effectively; 3) when MAb distribution is non-uniform, absorbed dose is more homogeneous with longer range beta-emitters.
Fujimori
K
K
Department of Nuclear Medicine, Hokkaido University School of Medicine.
Furudate
M
M
D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016499:Radioimmunotherapy; D011874:Radiometry; D011879:Radiotherapy Dosage