Regional low-dose interleukin-2 immunotherapy of lymph node micrometastasis in a guinea pig tumor model.
Strain 2 guinea pigs bearing the transplanted intradermally growing line 10 tumor underwent surgical excision of the primary lesion at a time when the tumor had already metastasized to the first draining lymph node. Postoperative perilymphatic immunotherapy with 500 or 5,000 IU of interleukin-2 (IL-2) for 12 consecutive days failed to cure the animals of residual lymphatic micrometastasis. Similarly, intratumoral IL-2 treatment of nonoperated guinea pigs did not alter the natural course of the disease. However, histological serial examination of the tumor-draining lymph nodes at the end of immunotherapy revealed significantly less tumor occupation in all IL-2-treated animals as compared to control animals.
Bier
H
H
Department of Otorhinolaryngology, Heinrich Heine University, Düsseldorf, FRG.
Haas
I
I
Koldowski
P
P
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000556:secondary; D005260:Female; D006168:Guinea Pigs; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008297:Male; D009368:Neoplasm Transplantation
D007376:Interleukin-2