Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior.
Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significantly promotes and maintains smoking behavior.
Aceto
M D
MD
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.
Scates
S M
SM
Ji
Z
Z
Bowman
E R
ER
D000698:Analgesia; D000818:Animals; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000037:antagonists & inhibitors*; D009270:Naloxone / Q000494:pharmacology*; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects; D012907:Smoking
D009270:Naloxone; D009538:Nicotine; D009020:Morphine