Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of the literature.
A case is presented of an intraocular T-cell lymphoma mimicking a ring melanoma of the iris and being the first manifestation of systemic disease. A 51-year-old woman was referred with an anterior uveitis, initially presenting as a granulomatous iritis. Nodules had developed in the circumference and the lesion now imitated a malignant melanoma of the iris, which was also the diagnosis from a biopsy specimen with routine staining. Clinical, haematological and serological examination revealed no other symptoms or signs. Lymphocytic markers applied to the biopsy specimen and to the enucleated eye revealed a highly malignant T-cell lymphoma infiltrating the iris, ciliary body, anterior choroid, retina and the adjacent vitreous body. Further examination later showed T-cell lymphoma in the bone marrow, the only other organ involved. The patient died in a leukaemic phase about 1 year after the first admission. Previous cases of T-cell lymphoma with ocular involvement are reviewed.
Jensen
O A
OA
Eye Pathology Institute, University of Copenhagen, Denmark.
Johansen
S
S
Kiss
K
K
D002924:Ciliary Body / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015811:Iris Neoplasms / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000473:pathology*; D014606:Uveitis, Anterior / Q000150:complications