title: Idiopathic recurring stupor.
abstract: Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.
authors.affiliation: Institute of Neurology, University of Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tinuper
authors.forename: P
authors.initials: P
authors.lastname: Montagna
authors.forename: G
authors.initials: G
authors.lastname: Plazzi
authors.forename: P
authors.initials: P
authors.lastname: Avoni
authors.forename: A
authors.initials: A
authors.lastname: Cerullo
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: E
authors.initials: E
authors.lastname: Sforza
authors.forename: E P
authors.initials: EP
authors.lastname: Bonetti
authors.forename: P
authors.initials: P
authors.lastname: Schoch
authors.forename: J D
authors.initials: JD
authors.lastname: Rothstein
mesh_terms: D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000097:blood; D003128:Coma / Q000097:blood / Q000503:physiopathology*; D026261:Diazepam Binding Inhibitor; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor