title: The effects of corticosteroids on lateral bias in female rats.
abstract: In Experiment 1 female rats were given one trial per day for 8 days in a T-maze, and their initial direction of choice (left/right) was noted. Vaginal smears were also obtained daily. After this some animals were adrenalectomized and given Ringer's solution; others were adrenalectomized and given hydrocortisone replacement; a third group was sham adrenalectomized, and a fourth group was an intact control. A week after surgery the animals were again tested for 8 days in the T-maze and vaginal smears were obtained. In Experiment 2 rats were subjected to the same surgical treatments as described above and were then tested for 8 days in the T-maze. In Expt. 1 there was no direction bias among the four groups prior to surgery. However, after surgery the Adrenalectomy+Ringer's group showed a significant increase in their rightward choices in the T-maze. This was also found in Expt. 2. Both adrenalectomized groups in Expt. 1 had a significant reduction in the duration of the estrus phase of their cycle. We conclude that corticosterone can affect lateral preference in a T-maze through a mechanism independent of the hormonal changes involved in the estrus cycle.
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
authors.lastname: Rizhova LYu
authors.forename: D A
authors.initials: DA
authors.lastname: Kulagin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D002755:Choice Behavior / Q000187:drug effects* / Q000502:physiology; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004971:Estrus / Q000187:drug effects / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000187:drug effects* / Q000502:physiology; D006854:Hydrocortisone / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D009949:Orientation / Q000187:drug effects* / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology; D011340:Problem Solving / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone