Gastric epithelial atypia complicating hepatic arterial infusion chemotherapy.
Severe gastric lesions developed in five patients during hepatic arterial infusion chemotherapy employing 5-fluorouracil plus either leucovorin or mitomycin C. Ulceration with marked epithelial atypia was observed with striking structural distortion and cellular pleomorphism of the affected gastric mucosa. These features should be considered to be a complication of such treatment and should not be misinterpreted as malignancy.
Kwee
W S
WS
Department of Pathology, St Laurentius Hospital, Roermond, The Netherlands.
Wils
J A
JA
Schlangen
J
J
Nuyens
C M
CM
Arends
J W
JW
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000473:pathology