Prognostic value of cerebrospinal fluid neuron-specific enolase and S-100b protein in Guillain-Barré syndrome.
We measured the cerebrospinal fluid (CSF) concentrations of neuron-specific enolase (NSE) and S-100b protein (S-100b) using enzyme immunoassay methods, in 24 patients with Guillain-Barré syndrome and 46 controls, and examined their prognostic values. Sixteen of 24 patients showed elevated levels (> the mean + 2SD levels of controls) of NSE, S-100b, or both, and in those with higher NSE or S-100b levels there was a rather longer duration of disease, whereas 8 patients with the normal levels showed an early recovery. Further, NSE or S-100b levels were significantly correlated with months to recovery. Thus, NSE and S-100b in CSF may be useful markers for predicting the outcome of Guillain-Barré syndrome.
Mokuno
K
K
Department of Neurology, Nagoya University School of Medicine, Japan.
Kiyosawa
K
K
Sugimura
K
K
Yasuda
T
T
Riku
S
S
Murayama
T
T
Yanagi
T
T
Takahashi
A
A
Kato
K
K
D000293:Adolescent; D000328:Adult; D002135:Calcium-Binding Proteins / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors; D009460:Neurologic Examination; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D011129:Polyradiculoneuropathy / Q000175:diagnosis* / Q000201:enzymology; D011379:Prognosis; D012016:Reference Values; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*
D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase