Mucinous carcinoma of the skin: report of a case with DNA cytofluorometric study.
A 62-year-old man with a mucinous carcinoma of the skin on the left cheek is described. The excised specimen showed a characteristic histopathologic picture. The findings from histochemical, immuno-histochemical, and electron microscopic examinations suggested an eccrine differentiation of the tumor cells. The removed tumor was examined using DNA cytofluorometry in order to analyze the cell kinetics and to estimate its biological behavior and prognosis. The tumor cells showed a diploid mode with a small number of polyploid cells. Only a small number of cells in the S and G2/M phase ranges were detected. After four years, there has been no evidence of tumor recurrence nor metastasis. The results of DNA ploidy analysis were thus compatible with the nature of slow growth with a good prognosis in this case.
Katoh
N
N
Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.
Hirano
S
S
Hosokawa
Y
Y
Miyashita
A
A
Kishimoto
S
S
Yasuno
H
H
D002288:Adenocarcinoma, Mucinous / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D005434:Flow Cytometry; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm; D005819:Genetic Markers