[The participation of the delta opioid receptors in immunomodulation].
The delta-receptors agonist DSLET inhibited immune responses in the CBA mice. The immunosuppression was shown to be due to an interaction with the serotoninergic system. No immunostimulating effect of the delta-opioid receptors antagonist ICI 174,864 occurred in the animals with dissection of the pituitary stalk. The immunostimulation was shown to be realised via the thymus and prevented by a preliminary haloperidol blockade of the D-2 dopaminergic receptors. The cerebral delta-opioid receptors seem to participate in neuro-immunomodulation through the interaction with the serotonin and dopamine neurotransmitter systems.
Cheĭdo
M A
MA
Idova
G V
GV
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009292:Narcotic Antagonists / Q000494:pharmacology; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000276:immunology*; D010902:Pituitary Gland / Q000187:drug effects / Q000276:immunology; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
D009292:Narcotic Antagonists; D017465:Receptors, Opioid, delta; D003533:Cyproheptadine; D004743:Enkephalin, Leucine; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; C040643:N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine; D006220:Haloperidol
Uchastie opiatnykh del'ta-retseptorov v immunomoduliatsii.