title: Werner's syndrome associated with spastic paraparesis and peripheral neuropathy.
abstract: A Werner's syndrome patient with spastic paraparesis and polyneuropathy had slowing of central and peripheral nerve conduction. Sural nerve biopsy revealed a significantly higher frequency of demyelination and remyelination and a loss of myelinated fibers. These data suggest that the central and peripheral nervous systems are affected in Werner's syndrome.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Umehara
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Izumo
authors.forename: K
authors.initials: K
authors.lastname: Arimura
authors.forename: K
authors.initials: K
authors.lastname: Matsumuro
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D003711:Demyelinating Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D013497:Sural Nerve / Q000473:pathology; D014898:Werner Syndrome / Q000175:diagnosis*