Pharmacological regulation of AP-1 transcription factor DNA binding activity.
The AP-1 transcription factor family consists of two groups of proteins, fos-related antigens (fra) and jun proteins. These transcription factors are usually expressed at low basal levels but they can be dramatically induced in a variety of cell types by many different stimuli, in which the quantity of AP-1 transcription factor and the DNA binding activity also rise. The quantity and DNA binding activity of transcription factors are not always at low levels. For example, early in brain development a high basal expression of AP-1 DNA binding activity exists. Similarly, adult rat adrenal gland contains high levels of AP-1 DNA binding activity whose regulation appears to be through post-translational modification (i.e., phosphorylation). Thus, AP-1 DNA binding activity is modulated in a developmental and tissue-specific manner.
Pennypacker
K R
KR
National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Hong
J S
JS
McMillian
M K
MK
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D004247:DNA / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics* / Q000378:metabolism
D016755:Proto-Oncogene Proteins c-jun; D004247:DNA