Experimental congestive splenomegaly: histological observations in the rat.
In course of experimental pre-hepatic portal hypertension in the rat, the most important histological alterations in the spleen, are represented by pooling of blood in the red pulp, activation of the macrophagic system, with hyperplasia of the histiocytes, increase of reticular fibers and of subcapsular myo-fibroblasts, and finally by evolution towards a diffuse fibrosis all over the parenchyma.
Manenti
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Cattedra di Patologia speciale Chirurgica, Università di Modena.
Botticelli
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Gibertini
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Botticelli
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D000818:Animals; D004108:Dilatation, Pathologic; D005355:Fibrosis; D006975:Hypertension, Portal / Q000150:complications; D008297:Male; D012157:Mononuclear Phagocyte System / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000098:blood supply; D013163:Splenomegaly / Q000209:etiology / Q000473:pathology*; D013997:Time Factors; D014680:Veins