HTLV-I-related retroviral markers in Hungarian patients with mycosis fungoides.
Cell and serum samples from 7 Hungarian patients with mycosis fungoides were examined for the presence of HTLV-I-related DNA sequences and antibodies recognizing HTLV-I antigens. DNA sequences distantly related to the proviral DNA of HTLV-I were shown by Southern blot hybridization in 3 patients. Serum samples from these patients contained antibodies reactive with the internal core polypeptides of HTLV-I and HTLV-II, but not with the env gene encoded type-specific HTLV antigens. Restriction enzyme analysis with EcoRI, PstI, BamHI and SacI revealed structural similarity of the provirus(es) integrated in the DNA of mycosis fungoides cells to HTLV-I but not to HTLV-II. Data suggest that these proviruses and HTLV-I are similar to each other along gag and pol regions.
Kiss
J
J
Institute of Microbiology, University Medical School, Debrecen, Hungary.
Tisza
T
T
Tóth
F D
FD
Horváth
A
A
Stumpf
A
A
D004279:DNA, Viral / Q000302:isolation & purification; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications* / Q000453:epidemiology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D009182:Mycosis Fungoides / Q000150:complications* / Q000453:epidemiology; D011533:Proviruses / Q000235:genetics / Q000302:isolation & purification; D012190:Retroviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012878:Skin Neoplasms / Q000150:complications* / Q000453:epidemiology
D004279:DNA, Viral; D015481:HTLV-I Antibodies