Interaction between tolbutamide and ketoconazole in healthy subjects.
A possible interaction between tolbutamide and ketoconazole was studied in seven healthy volunteers. Treatment for 1 week with 200 mg oral ketoconazole increased the elimination half-life (from mean +/- s.d. 3.7 +/- 0.4 to 12.3 +/- 1.9 h) and AUC(0.12 h) of tolbutamide (from 309 +/- 27 to 546 +/- 20 micrograms ml-1 h) by 25 +/- 64 and 66 +/- 15%, respectively. The percentage blood glucose reduction was also increased when tolbutamide and ketoconazole were coadministered.
Krishnaiah
Y S
YS
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India.
Satyanarayana
S
S
Visweswaram
D
D
D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004347:Drug Interactions; D004357:Drug Synergism; D006207:Half-Life; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D014044:Tolbutamide / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D001786:Blood Glucose; D014044:Tolbutamide; D007654:Ketoconazole