Synthesis and anticonvulsant activity of new dibenzo[1,2]thiazepine S,S-dioxides.
A new series of 11-substituted 6,11-dihydro-6-methyl-dibenzo[c,f]-[1,2]thiazepine S,S-dioxides was synthesized. Some of the components show significant anticonvulsant activity in the MES, pentetrazol and strychnine tests. The more active compounds are devoid of neurotoxic effects.
Diaz
J A
JA
Instituto de Química Médica, CSIC, Juan de la Cierva, Madrid, Spain.
Montero
E
E
Vega
S
S
Darias
V
V
Tello
M L
ML
Abdallah
S S
SS
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D003987:Dibenzothiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D013055:Spectrophotometry, Infrared
D000927:Anticonvulsants; D003987:Dibenzothiazepines