[Post-transfusion hemochromatosis. Results of a study carried out in Blood Transfusion Centers. Analysis of 15 cases treated with subcutaneous perfusion of Desferal. Working group "Transfusion Techniques and Therapeutics"].
Post-transfusional iron overload is a real problem for doctors in charge of transfusions, as shown by the survey we led in twenty French blood banks. Deferoxamine remains the most efficient chelator, but can be prescribed only in a parenteral way. It is now proved that continuous infusions, intravenous or subcutaneous, are preferable to intermittent injections as far as iron excretion is concerned. In our study, we selected 15 polytransfused patients for dysmyelopoiesis. 13 cases were analysed by measuring the serum ferritin level. A clear decrease was noted, as well as a relative normalization of serum alanine amino transferases. However, if this treatment is effective and well tolerated, the problem is that it obviously requires the patient's compliance. It seems important to us to optimize prevention and treatment of post-transfusional iron overload through a consensus.
Jaulmes
D
D
C.T.S. Pitié-Salpétrière, Paris.
Quarre
M C
MC
Audat
F
F
Gaonach
M J
MJ
D003676:Deferoxamine / Q000008:administration & dosage*; D005602:France; D006432:Hemochromatosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007279:Injections, Subcutaneous; D010477:Perfusion; D012189:Retrospective Studies; D065227:Transfusion Reaction
D003676:Deferoxamine
L'hémochromatose post-transfusionnelle. Résultats d'une enquête menée auprès des Etablissements de Transfusion Sanguine en France. Analyse de 15 cas traités par perfusion sous-cutanée de Desféral. Groupe de travail Techniques et Thérapeutiques Transfusionnelles.