The effect of repeated administration of methamphetamine on dopamine uptake sites in rat striatum.
In this experiment, rats were injected intraperitoneally with 6 mg/kg methamphetamine (MAP) hydrochloride or the same volume of saline once daily for 14 days. Rats were decapitated after a 1-day, 4-day or 10-day withdrawal period. The number and affinity of [3H]mazindol binding sites in the striatum were measured. Their number in the MAP group decreased as compared with controls after a 1-day withdrawal period, but returned to the control level after a 4-day and 10-day withdrawal period. These results are believed to show that the decrease in dopamine uptake sites after repeated administration of MAP is transient and does not contribute to MAP-induced behavioral sensitization.
Ikawa
K
K
Department of Neuropsychiatry, Tokyo Metropolitan Hiroo General Hospital, Japan.
Watanabe
A
A
Motohashi
N
N
Kaneno
S
S
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008454:Mazindol / Q000378:metabolism; D008694:Methamphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D015102:3,4-Dihydroxyphenylacetic Acid; D008694:Methamphetamine; D008454:Mazindol; D004298:Dopamine; D006719:Homovanillic Acid