title: Inactivation of HIV, HBV, HCV related viruses and other viruses in human plasma derivatives by pasteurisation.
abstract: Laboratory studies were made to verify the capacity and efficacy of the pasteurisation step (heat treatment at 60 degrees C for 10 hours in stabilized aqueous solution) in inactivating various pathogenic viruses (e.g. HIV, HBV, HCV related viruses, HAV, HSV, poliovirus). These experiments proved that pasteurisation effectively inactivates a broad spectrum of viruses with a range of different physicochemical properties. The results, summarized in inactivation kinetics, demonstrate that complete inactivation of high quantities of both enveloped (e.g. HIV, HCV related viruses) and non-enveloped (e.g. poliovirus) viruses takes place during pasteurisation. In clinical trials on the virus safety of plasma derivatives no case of AIDS, hepatitis B or C occurred. From these data we conclude that heat treatment at 60 degrees C in a stabilized aqueous solution confers a high margin of safety on human plasma protein preparations regarding the transmission of diseases such as AIDS or hepatitis.
authors.affiliation: Microbiology Research Laboratories, Behringwerke AG, Marburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Nowak
authors.forename: M
authors.initials: M
authors.lastname: Niedrig
authors.forename: D
authors.initials: D
authors.lastname: Bernhardt
authors.forename: J
authors.initials: J
authors.lastname: Hilfenhaus
mesh_terms: D001688:Biological Products; D002986:Clinical Trials as Topic; D004340:Drug Contamination / Q000517:prevention & control; D018067:Flaviviridae / Q000502:physiology; D006678:HIV / Q000502:physiology*; D016174:Hepacivirus / Q000502:physiology*; D006515:Hepatitis B virus / Q000502:physiology*; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D010849:Picornaviridae / Q000502:physiology; D010949:Plasma / Q000382:microbiology*; D011446:Prospective Studies; D012449:Safety; D014777:Virus Diseases / Q000517:prevention & control; D014779:Virus Replication
chemical_list: D001688:Biological Products