Prevalence of HLA-DR3 and autoantibodies to connective tissue components in Dupuytren's contracture.
Forty-six patients with Dupuytren's contracture (DC) and 55 control persons were HLA-typed for class I and HLA-DR class II antigens and were investigated for the presence of autoantibodies against elastin (ELAB) and collagen types I-IV (ACA I-IV). Using the chi 2 test, obtained from 2 x 2 contingency tables, a significant association was found between DC and HLA-DR3 and autoantibodies to types I-IV collagen. ELAB and ACA I and III were significantly correlated with HLA-DR3 in the whole group of patients plus controls. In analogy to other diseases with autoimmunologic features the presence of HLA-DR3 therefore seems to indicate a higher risk for the formation of connective tissue autoantibodies. The remodeling processes during the course of fibrosis in DC might be responsible for this autoantibody formation.
Neumüller
J
J
Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna-Oberlaa, Austria.
Menzel
J
J
Millesi
H
H
D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D003094:Collagen / Q000276:immunology; D003238:Connective Tissue / Q000276:immunology*; D004387:Dupuytren Contracture / Q000453:epidemiology / Q000276:immunology*; D004549:Elastin / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D015803:HLA-DR3 Antigen / Q000032:analysis*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012016:Reference Values
D000941:Antigens; D001323:Autoantibodies; D015803:HLA-DR3 Antigen; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D003094:Collagen; D004549:Elastin