Arteritis of both carotid arteries in a patient with focal, crescentic glomerulonephritis and anti-neutrophil cytoplasmic autoantibodies.
We report a 32-yr-old woman who suffered a stroke as a consequence of arteritis of both internal carotid arteries confirmed by selective carotid arteriography. Laryngeal inflammation and kidney biopsy proven focal crescentic glomerulonephritis were also present in this patient. Anti-neutrophil cytoplasmic autoantibodies with specificity for proteinase 3 were detected in high titre during the active phase of the disease. This overlap syndrome with features indicating both Takayasu's arteritis and Wegener's granulomatosis suggests a common pathogenesis for these diseases.
Logar
D
D
University Medical Centre, Department of Rheumatology, Ljubljana, Slovenia.
Rozman
B
B
Vizjak
A
A
Ferluga
D
D
Mulder
A H
AH
Kallenberg
C G
CG
D000328:Adult; D000792:Angiography; D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001167:Arteritis / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D001323:Autoantibodies / Q000032:analysis*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D006801:Humans
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies