title: [Long term continuous combination of cisplatin and 5 fluorouracil in advanced breast neoplasms. A retrospective study of 77 patients].
abstract: Seventy-seven pre-treated patients with advanced breast cancer were administered a combination chemotherapy with cisplatin 50 mg/sqm d1, 5-fluorouracil 300 mg/sqm/d protracted continuous infusion d1-d28, allopurinol 600 mg/d po d1-d28, q29d. Overall response rate was 26%, median survival time 46 weeks, survival rate 43.3% at 1 year, 20.2% at 2 years, 10.6% at 3 years. Response rate was rather high in CNS and meningeal involvement (6/10).
authors.affiliation: Département d'oncologie médicale, Centre Alexis-Vautrin, Vandoeuvre-lès-Nancy, France.
authors.forename: D
authors.initials: D
authors.lastname: Spaeth
authors.forename: T
authors.initials: T
authors.lastname: Conroy
authors.forename: I
authors.initials: I
authors.lastname: Krakowski
authors.forename: L
authors.initials: L
authors.lastname: Geoffrois
authors.forename: E
authors.initials: E
authors.lastname: Luporsi
authors.forename: M
authors.initials: M
authors.lastname: Rios
authors.forename: B
authors.initials: B
authors.lastname: Weber
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Association cisplatine et 5-fluorouracile continu à long terme dans les cancers du sein avancés. Etude rétrospective de 77 patientes.