Induction of squamous cell carcinomas in the mouse lung after long-term inhalation of polycyclic aromatic hydrocarbon-rich exhausts.
A 10-month inhalation study using newborn female mice was performed to determine pulmonary tumorigenicity of polycyclic aromatic hydrocarbon (PAH)-enriched exhausts. At two exhaust doses containing 50 micrograms/m3 (group II) and 90 micrograms/m3 benzo(a)pyrene (BaP) (group III) a significant increase of lung tumors was observed and the incidence of malignant lung tumors was dose-dependent. Bronchiolo-alveolar adenomas were observed in all mice of groups II and III (40/40 each) as compared to 5/40 in the control (group I). Bronchiolo-alveolar adenocarcinomas developed in 10/40 and in 33/40 mice of groups II and III, respectively, but were absent in group I. Single or multiple squamous cell carcinomas, which showed variable degrees of differentiation were observed exclusively in 6 mice of group III. One adenosquamous carcinoma was seen in an further animal of this group.
Schulte
A
A
Fraunhofer Institute of Toxicology and Aerosol Research Hannover, Germany.
Ernst
H
H
Peters
L
L
Heinrich
U
U
D000818:Animals; D000831:Animals, Newborn; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D051379:Mice; D011083:Polycyclic Compounds / Q000633:toxicity*
D011083:Polycyclic Compounds