Serum 2'-5'-oligoadenylate synthetase levels and clinical response to interferon-beta therapy in women with genital human papillomavirus infection.
To investigate the activity of parenterally administered interferon-beta (IFN-beta) in women with genital human papillomavirus (HPV) infection, serum 2'-5'-oligoadenylate synthetase (2'-5'OAS), an enzyme induced by IFNs, was measured before, during, and after therapy. Serum levels of 2'-5'OAS significantly increased during therapy (P = .005). The patients classified as not responding to treatment at 3 months of follow-up had baseline levels of 2'-5'OAS significantly higher than those who responded to treatment (P = .0011). Differences between the IFN-beta-treated group and untreated controls appeared at day 6 (P = .0019). 2'-5'OAS is a useful parameter in monitoring parenterally administered IFN-beta. The data suggest that women with genital HPV infection and elevated baseline levels of 2'-5'OAS are unlikely to respond to therapy with IFN-beta.
Rusconi
S
S
Clinic of Infectious Diseases, L. Sacco Hospital, University of Milan, Italy.
Agarossi
A
A
Ravasi
L
L
Tonta
A
A
Conti
M
M
Galli
M
M
D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood*; D000328:Adult; D003218:Condylomata Acuminata / Q000201:enzymology* / Q000628:therapy; D004790:Enzyme Induction; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008875:Middle Aged; D027383:Papillomaviridae / Q000187:drug effects
D016899:Interferon-beta; D015088:2',5'-Oligoadenylate Synthetase