Infection and inhibition of human cytotoxic T lymphocytes by herpes simplex virus.
The effect of herpes simplex virus type 1 (HSV-1) infection on human cytotoxic T-lymphocyte (CTL) lytic function was assessed. All HSV-infected CTL populations tested were significantly inhibited in lysing target cells. The inhibition of CTL lytic function by infection with HSV-1 was independent of T-cell receptor-mediated antigen recognition and did not involve virus-induced shutoff of host protein synthesis, the expression of the HSV-1 transactivation protein, ICP4, or replicating virus. Understanding the functional impairment of CTL following infection with HSV may have important implications for HSV-induced immunosuppression and the mechanism of HSV persistence in immunocompetent hosts.
Posavad
C M
CM
Department of Pathology, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.
Newton
J J
JJ
Rosenthal
K L
KL
D003602:Cytotoxicity, Immunologic; D006561:Herpes Simplex / Q000276:immunology / Q000382:microbiology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D017874:Immediate-Early Proteins / Q000276:immunology; D066298:In Vitro Techniques; D007519:Isoantigens; D007959:Lymphocyte Culture Test, Mixed; D009154:Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000382:microbiology*; D014407:Tumor Cells, Cultured / Q000276:immunology
D017874:Immediate-Early Proteins; D007519:Isoantigens; C048925:herpes simplex virus, type 1 protein ICP4