title: Actin-bundling proteins.
abstract: Recent studies have greatly expanded our understanding of actin-bundling proteins. A new group of actin-bundling proteins, the fascins, has been recognized. An actin-bundling protein inhibits actin depolymerization even under conditions in which it cannot produce a gel, which suggests that bundling proteins may affect actin filament dynamics. A villin-like protein is present in Dictyostelium, shedding doubt on current ideas on the evolution of villin. Domain mapping continues to be a major thrust of research into most groups of bundling proteins.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392.
authors.forename: J J
authors.initials: JJ
authors.lastname: Otto
mesh_terms: D000185:Actinin / Q000502:physiology*; D000199:Actins / Q000502:physiology*; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D004023:Dictyostelium / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D008840:Microfilament Proteins / Q000502:physiology*
chemical_list: D000199:Actins; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; C026742:plastin; C026615:villin; D000185:Actinin; C020324:fascin