title: Aortic homograft and mitral valve repair in a patient with Werner's syndrome.
abstract: We report the case of a 66-year-old man suffering from Werner's syndrome (adult progeria); he presented with several cardiac disorders, including coronary artery disease, aortic stenosis, and mitral regurgitation, mainly due to calcific deposits in the mitral annulus and the aortic cusps. Treatment consisted of mitral repair, homograft replacement of the aortic valve, and coronary artery bypass grafting. Avoidance of prosthetic material because of chronic infectious skin ulcers constituted the main goal of the operation.
authors.affiliation: Clinic for Cardiovascular Surgery, University Hospital, Zürich, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Carrel
authors.forename: M
authors.initials: M
authors.lastname: Pasic
authors.forename: T
authors.initials: T
authors.lastname: Tkebuchava
authors.forename: J
authors.initials: J
authors.lastname: Turina
authors.forename: R
authors.initials: R
authors.lastname: Jenni
authors.forename: M I
authors.initials: MI
authors.lastname: Turina
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000637:transplantation*; D000075202:Contraindications; D006349:Heart Valve Diseases / Q000150:complications / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D014898:Werner Syndrome / Q000150:complications* / Q000601:surgery