title: Big endothelin in spontaneous intracerebral hemorrhage.
abstract: Plasma big endothelin (BE) levels were studied in 17 patients during the first 2 weeks following spontaneous intracerebral hemorrhage (ICH). Three patients had experienced an infratentorial hemorrhage of the pons and cerebellum. The group of 14 patients with supratentorial hemorrhage presented with 8 hematomas of the putamen, 4 of the capsula interna and 2 in the thalamus. Significant elevations of BE during the first 2 weeks after the initial ICH, significant differences between the different localisations and between patients with different prognoses were not apparent (mean BE level: 2.95 +/- 1.39, control group: 2.68 +/- 1.29 fmol/ml). These results support the theory that endothelins do not play a significant pathophysiological role in acute severe ICH.
authors.affiliation: Department of Neurology, University of the Saarland, Homburg, FRG.
authors.forename: G F
authors.initials: GF
authors.lastname: Hamann
authors.forename: E
authors.initials: E
authors.lastname: Isenberg
authors.forename: M
authors.initials: M
authors.lastname: Strittmatter
authors.forename: M
authors.initials: M
authors.lastname: Stoll
authors.forename: T
authors.initials: T
authors.lastname: Keshevar
authors.forename: R
authors.initials: R
authors.lastname: Moili
authors.forename: K
authors.initials: K
authors.lastname: Schimrigk
mesh_terms: D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis; D002552:Cerebral Ventricles / Q000503:physiopathology; D019332:Endothelin-1; D016232:Endothelins / Q000097:blood*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D011863:Radioimmunoassay; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000175:diagnosis
chemical_list: D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors