Myocardial collagen and its functional role.
Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in a stiffer myocardium and ventricular diastolic dysfunction.
Janicki
J S
JS
Dalton Research Center, University of Missouri, Columbia 65212.
Matsubara
B B
BB
Kabour
A
A
D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen / Q000378:metabolism*; D004719:Endomyocardial Fibrosis / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D016276:Ventricular Function / Q000502:physiology*
D003094:Collagen