title: Blood/air partition coefficient determinations: automation and improvement of the equilibrium partitioning in closed systems method.
abstract: The equilibrium partitioning in closed systems method has been frequently used for determining partition coefficients between liquid and gas phases. We developed several improvements in this method: preparation of test atmospheres with a dynamic solvent vapor generator, automation of gas phase analysis, and estimation of the precision of the partition coefficients using a statistical procedure that did not require pairing of test and reference measurements. Blood/air partition coefficients measured in a blood-bank blood sample for acetone, 1,1,1-trichloroethane, toluene, and styrene were: 309 +/- 2, 5.6 +/- 0.1, 16.2 +/- 0.5 and 49 +/- 2 (geometric mean +/- estimated SE, respectively). Water/air partition coefficients were: 361 +/- 7, 2.9 +/- 0.3, 4.6 +/- 0.5, and 6.9 +/- 0.9 for acetone, 1,1,1-trichloroethane, toluene, and styrene.
authors.affiliation: Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
authors.forename: R L
authors.initials: RL
authors.lastname: Dills
authors.forename: W S
authors.initials: WS
authors.lastname: Ackerlund
authors.forename: D A
authors.initials: DA
authors.lastname: Kalman
authors.forename: M S
authors.initials: MS
authors.lastname: Morgan
mesh_terms: D000096:Acetone / Q000493:pharmacokinetics; D001322:Autoanalysis / Q000379:methods*; D015824:Blood-Air Barrier / Q000502:physiology*; D006801:Humans; D020058:Styrene; D013343:Styrenes / Q000493:pharmacokinetics; D014050:Toluene / Q000493:pharmacokinetics; D014240:Trichloroethanes / Q000493:pharmacokinetics
chemical_list: D013343:Styrenes; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; D000096:Acetone; D014050:Toluene; D020058:Styrene