B cell antigen receptors.
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen receptor is functionally divided into the ligand-binding immunoglobulin (Ig) molecule and the signal-transducing Ig-alpha/Ig-beta heterodimer. This knowledge has been exploited to design variant antigen receptors which combine both functions in a single molecule.
Reth
M
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Max-Planck Institut für Immunbiologie, Freiburg, Germany.
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000737:chemistry / Q000276:immunology; D008969:Molecular Sequence Data; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell