title: Herpes simplex esophagitis after renal transplantation.
abstract: This paper describes five renal transplant recipients, out of a series of 221 consecutive patients, who developed herpes simplex esophagitis. This opportunistic infection presented as odyno- and/or dysphagia. It occurred during or shortly after treatment of acute cellular rejection episodes with high doses of steroids and, in four cases, of anti-lymphocyte globulins. The infection responded to acyclovir in all patients. We conclude from these observations that herpes esophagitis occurs during periods of intensive immunosuppression. Because its endoscopic manifestations are variable, biopsies and cultures are essential to reach the diagnosis. Prevention may be possible by avoiding transplantation from a seropositive donor to a negative recipient and by prophylactic oral acyclovir.
authors.affiliation: Department of Surgery, University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Mosimann
authors.forename: P F
authors.initials: PF
authors.lastname: Cuénoud
authors.forename: F
authors.initials: F
authors.lastname: Steinhäuslin
authors.forename: J P
authors.initials: JP
authors.lastname: Wauters
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D004941:Esophagitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D004945:Esophagoscopy; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007262:Infusions, Intravenous; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D000212:Acyclovir