title: Acute hypoxemic respiratory failure following intrapleural thrombolytic therapy for hemothorax.
abstract: Intrapleural instillation of thrombolytic agents has been useful in the treatment of hemothorax when thoracostomy tube drainage is unsuccessful. We present a patient who developed acute hypoxemic respiratory failure following the intrapleural instillation of both streptokinase and urokinase 24 h apart. Hypoxemia most likely resulted from a direct effect of the products of fibrinolysis on the pulmonary circulation.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston.
authors.forename: M D
authors.initials: MD
authors.lastname: Frye
authors.forename: M
authors.initials: M
authors.lastname: Jarratt
authors.forename: S A
authors.initials: SA
authors.lastname: Sahn
mesh_terms: D000208:Acute Disease; D006491:Hemothorax / Q000188:drug therapy*; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced*; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D010994:Pleura; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D013300:Streptokinase / Q000008:administration & dosage / Q000009:adverse effects; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator