title: Mechanical circulatory support during repair of thoracic aortic injuries improves morbidity and prevents spinal cord injury.
abstract: OBJECTIVE
  Evaluation of mechanical circulatory support (MCS) vs simple cross clamping (CC) during repair of traumatic descending thoracic aortic transections.
  
  
  METHODS
  A retrospective analysis of all patients admitted with blunt traumatic injury to the descending thoracic aorta from August 1988 through March 1993. Patients were pseudorandomized to simple CC vs MCS according to the on-call surgeons' preferences.
  
  
  METHODS
  A level 1 trauma center in Seattle, Wash.
  
  
  METHODS
  Forty-two patients were admitted. Thirty (71%) survived, 21 of whom underwent repair with MCS and nine underwent repair with CC only.
  
  
  METHODS
  Prompt aortic repair was performed either primary or by replacement with a Dacron graft.
  
  
  METHODS
  Operative survivors were examined for new neurologic deficits, renal function, pulmonary failure, gastrointestinal tract complications, sepsis, and length of hospitalization. Causes of death in all patients were determined.
  
  
  RESULTS
  Twelve patients died, seven before surgery and five during surgery. In survivors, new neurologic deficits occurred in four (44%) of nine patients undergoing repair with CC and in none of the patients undergoing repair with MCS (P = .0005). Mean (+/- SEM) postoperative serum creatinine levels were higher in patients undergoing repair with CC (256 +/- 80 mumol/L [2.9 +/- 0.9 mg/dL]) than in patients undergoing repair with MCS (115 +/- 18 mumol/L [1.3 +/- 0.2 mg/dL]) (P < .05). Patients undergoing repair with CC had longer hospitalization and higher incidence of pulmonary, gastrointestinal, and septic complications, all of which approached statistical significance.
  
  
  CONCLUSIONS
  Mechanical extracorporeal perfusion of the distal aorta during occlusion of the thoracic aorta for traumatic descending thoracic aortic injuries may prevent spinal cord ischemia and reduce postoperative organ dysfunction.
authors.affiliation: Division of Thoracic Surgery, Harborview Medical Center, University of Washington, Seattle.
authors.forename: A D
authors.initials: AD
authors.lastname: Forbes
authors.forename: D G
authors.initials: DG
authors.lastname: Ashbaugh
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000293:injuries* / Q000601:surgery*; D003250:Constriction; D006353:Heart-Assist Devices; D006801:Humans; D015601:Injury Severity Score; D008875:Middle Aged; D009017:Morbidity; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000517:prevention & control*; D015996:Survival Rate; D014949:Wounds, Nonpenetrating / Q000150:complications