title: Therapy of experimentally induced coliform mastitis with a Propionibacterium acnes product.
abstract: The efficacy of a Propionibacterium acnes product for treatment of coliform mastitis was evaluated following intramammary infusion of Escherichia coli. Ten cows were injected intravenously with a product containing heat-killed P. acnes at 3 h, 3 d, and 7 d after bacterial challenge. Five cows served as untreated negative controls. Bacterial counts in milk, rectal temperatures, and milk SCC did not differ between treated cows and control cows. Intravenous infusion of P. acnes had no effect on milk production or DMI of treated cows compared with untreated controls. Therapy of experimentally induced coliform mastitis with a P. acnes product had no effect on severity or duration of clinical signs.
authors.affiliation: Department of Dairy Science, Ohio State University.
authors.forename: J S
authors.initials: JS
authors.lastname: Hogan
authors.forename: K L
authors.initials: KL
authors.lastname: Smith
authors.forename: D A
authors.initials: DA
authors.lastname: Todhunter
authors.forename: P S
authors.initials: PS
authors.lastname: Schoenberger
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D002417:Cattle; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D007774:Lactation; D008414:Mastitis, Bovine / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D008892:Milk / Q000378:metabolism / Q000382:microbiology; D011247:Pregnancy; D011425:Propionibacterium acnes / Q000276:immunology*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic