Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.
Cyclic nucleotide-gated cation channels are essential in visual and olfactory signal transduction. An additional member of the cGMP-gated channel family, termed CNG-3, has been cloned from bovine kidney. Its deduced amino acid sequence is 60% and 62% identical with the CNG-channel proteins from bovine rod outer segment and bovine olfactory epithelium, respectively. Northern analysis and sequences amplified by the PCR showed that the CNG-3 mRNA is present in testis, kidney, and heart. Calcium permeated the expressed channel in the presence of extracellular Mg2+ and Na+ at membrane potentials from -100 to +45 mV. It is likely that CNG-3 protein is responsible for cGMP-induced Ca2+ entry in cells other than sensory cells.
Biel
M
M
Institut für Pharmakologie und Toxikologie, Technischen Universität München, Germany.
Zong
X
X
Distler
M
M
Bosse
E
E
Klugbauer
N
N
Murakami
M
M
Flockerzi
V
V
Hofmann
F
F
D000818:Animals; D001483:Base Sequence; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000235:genetics*; D002417:Cattle; D003001:Cloning, Molecular; D015640:Ion Channel Gating; D007668:Kidney / Q000502:physiology; D008969:Molecular Sequence Data; D009712:Nucleotides, Cyclic / Q000502:physiology; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D015220:Calcium Channels; D009712:Nucleotides, Cyclic; D009838:Oligodeoxyribonucleotides; D002118:Calcium