Oxidative and antioxidative factors in the serum of thyroid cancer patients treated with 131I.
The variation of some parameters involved in maintaining the balance between pro- and anti-oxidative factors was followed-up in a group of patients thyroidectomized for folliculo-papillary, papillary and follicular cancer, before and after 5 days following the 131I administration. Radiotherapy led to the intensification of lipid peroxidation expressed by a significant increase in the malondialdehyde values. Among the parameters involved in the antioxidative process we noted an increase in both SH nonprotein groups and ceruloplasmin concentration. The total antioxidative capacity lowered significantly following irradiation, whereas uric acid remained unaltered.
Bartoc
R
R
C. I. Parhon Institute of Endocrinology, Bucharest, Romania.
Dumitrescu
C
C
Belgun
M
M
Olinescu
R
R
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D011182:Postoperative Care; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood* / Q000628:therapy; D013965:Thyroidectomy
D000975:Antioxidants; D007457:Iodine Radioisotopes; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde