Postnatal changes in [3H]mazindol-labelled dopamine uptake sites in the rat striatum following prenatal cocaine exposure.
The present study showed that prenatal cocaine exposure (60 mg/kg/day) has a transient effect on the [3H]mazindol-labelled dopamine uptake sites in the striatum of the rat offspring examined from postnatal week 0-32. There is a 39% and 21% decrease in the number of binding sites (Bmax) in the cocaine-exposed group at postnatal weeks 3 and 4, respectively, with a recovery to near normal values by postnatal week 8.
Stadlin
A
A
Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories.
Choi
H L
HL
Tsang
D
D
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D005260:Female; D008454:Mazindol / Q000493:pharmacokinetics / Q000494:pharmacology*; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000187:drug effects*; D015430:Weight Gain / Q000187:drug effects
D011954:Receptors, Dopamine; D008454:Mazindol; D003042:Cocaine