title: [Insulin-like growth factor I as a marker of nutritional status in patients on enteral nutrition].
abstract: In order to appraise type 1 insulin growth factor (IGF-1) as nutritional state marker in comparison with other known markers, seric IGF-1 (RIA), albumin, prealbumin, transferrin and retinol-bound protein were determined weekly in 15 patients with oropharyngeal neoplasm and 7 in the burns unit, all being administered enteral nutrition. At the beginning of the study, IGF-1 seric levels were significantly lower in the burns group compared with the neoplasm group (82.28 +/- 23.36 vs 137.58 +/- 66.2 ng/ml, p < 0.01). IGF-1 values in the first group were initially significantly lower in comparison with those for the same group at the end of the study (82.28-23.36 vs 177.11 +/- 53.87 ng/ml, p < 0.01 for paired data). No significant change was demonstrated in IGF-1 seric levels in the neoplasm group. IGF-1 seric levels showed a significant multiple correlation with albumin, prealbumin, transferrin and retinol-bound protein in both the group with burns (r = 0.696, p < 0.001) and that with neoplasms (r = 0.615, p < 0.001). The nitrogen balance revealed a univariant and significant linear correlation with IGF-1 (r = 0.373, p < 0.05) and with prealbumin (r = 0.377, p < 0.05). According to the data obtained, seric IGF-1 has a significant correlation with other well-known nutritional markers. In the burns group, the hypercatabolism was accompanied by a significant increase in seric IGF-1 levels.
authors.affiliation: Unidad de Nutrición Clínica, Hospital Universitario Virgen del Rocío, Sevilla, España.
authors.forename: P P
authors.initials: PP
authors.lastname: García-Luna
authors.forename: F
authors.initials: F
authors.lastname: Relimpio
authors.forename: F
authors.initials: F
authors.lastname: García de Pesquera
authors.forename: M
authors.initials: M
authors.lastname: Garrido
authors.forename: J L
authors.initials: JL
authors.lastname: Pereira
authors.forename: T
authors.initials: T
authors.lastname: Gómez-Cía
authors.forename: J
authors.initials: J
authors.lastname: Segura
authors.forename: J L
authors.initials: JL
authors.lastname: Serrera
authors.forename: R
authors.initials: R
authors.lastname: Astorga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood / Q000628:therapy; D002908:Chronic Disease; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D009959:Oropharyngeal Neoplasms / Q000097:blood / Q000628:therapy; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000628:therapy
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I
vernacular_title: El factor de crecimiento insulínico tipo 1 como marcador de estado nutricional en pacientes con nutrición enteral.