title: Phylogenetic relationship of Fusobacterium necrophorum A, AB, and B biotypes based upon 16S rRNA gene sequence analysis.
abstract: The 16S rRNA genes from virulent (AB) and benign (B) biotype strains of Fusobacterium necrophorum, the causative agent of ovine foot abscess, were cloned and sequenced. Notwithstanding the distinct phenotypic differences between the AB and B biotypes, a phylogenetic analysis in which the 16S rRNA gene sequences were used revealed the close relationship of these taxa. Comparison of the virulent and benign biotypes of F. necrophorum may therefore be a legitimate way to identify key virulence factors useful in vaccine development.
authors.affiliation: CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria, Australia.
authors.forename: L A
authors.initials: LA
authors.lastname: Nicholson
authors.forename: C J
authors.initials: CJ
authors.lastname: Morrow
authors.forename: L A
authors.initials: LA
authors.lastname: Corner
authors.forename: A L
authors.initials: AL
authors.lastname: Hodgson
mesh_terms: D015373:Bacterial Typing Techniques; D001483:Base Sequence; D004275:DNA, Ribosomal / Q000235:genetics*; D005675:Fusobacterium necrophorum / Q000145:classification* / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S