Does lansoprazole influence postprandial digestive function?
The effects of a potent proton pump inhibitor on postprandial digestive functions were compared with those of a placebo in a double-blind randomized crossover study. Six healthy male volunteers received 30 mg/day of lansoprazole or placebo for 7 days, with a wash-out period of 14 days. As compared to placebo, lansoprazole induced a marked decrease of mean +/- S.E.M. 3-h gastric acid secretion from 46.8 +/- 10.8 mmol to 10.9 +/- 2.5 mmol (P < 0.05), and a decrease of the volume of gastric contents emptying into the duodenum from 1043 +/- 139 ml to 660 +/- 87 ml (P < 0.05). However, gastric emptying remained unchanged with meal gastric emptying half times of 66 +/- 5 min and 67 +/- 13 min, respectively. During the 3-h postprandial period, duodenal lipase and chymotrypsin outputs were 366 +/- 123 KIU and 56 +/- 11 KIU with lansoprazole and 436 +/- 119 KIU and 49 +/- 8 KIU with placebo (N.S.). Bile acid outputs were 5.3 +/- 0.7 mmol and 6.0 +/- 1.0 mmol, respectively (N.S.) There was no change in kinetic profiles of biliary-pancreatic secretion. We conclude that potent inhibition of gastric secretion by chronic administration of a proton pump inhibitor at usual therapeutic dose alters neither meal gastric emptying nor postprandial biliary-pancreatic secretion.
Vidon
N
N
Laboratoire de pharmacie galénique, faculté de Pharmacie, Paris, France.
Dutreuil
C
C
Scoule
J C
JC
Delchier
J C
JC
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D002918:Chymotrypsin / Q000378:metabolism; D004063:Digestion / Q000187:drug effects*; D004311:Double-Blind Method; D004386:Duodenum / Q000201:enzymology; D004435:Eating; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D064747:Lansoprazole; D008049:Lipase / Q000378:metabolism; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000494:pharmacology
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001647:Bile Acids and Salts; D064747:Lansoprazole; D008049:Lipase; D002918:Chymotrypsin; D000251:Adenosine Triphosphatases; D009853:Omeprazole