title: Adjunctive clonazepam treatment of tic symptoms in children with comorbid tic disorders and ADHD.
abstract: The treatment of seven children and adolescents with a tic disorder and concomitant attention-deficit hyperactivity disorder (ADHD) is reviewed. Symptoms of ADHD were treated successfully with clonidine; however, patients experienced persistent tics. The patients were treated with the adjunctive use of clonazepam. The addition of clonazepam resulted in a further decrease in tic frequency and severity without affecting the coexisting ADHD symptoms. These cases suggest that clonazepam may be a useful adjunctive pharmacological intervention in treating tics in children with comorbid ADHD.
authors.affiliation: Department of Psychiatry, Children's Hospital, Boston, MA 02115.
authors.forename: R J
authors.initials: RJ
authors.lastname: Steingard
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: D R
authors.initials: DR
authors.lastname: DeMaso
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D002998:Clonazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D015897:Comorbidity; D004359:Drug Therapy, Combination; D006801:Humans; D011569:Psychiatric Status Rating Scales; D013981:Tic Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D002998:Clonazepam; D003000:Clonidine