title: Immunotherapy for Stewart-Treves syndrome. Usefulness of intrapleural administration of tumor-infiltrating lymphocytes against massive pleural effusion caused by metastatic angiosarcoma.
abstract: We describe a 56-year-old woman with Stewart-Treves syndrome who had severe dyspnea from a pleural effusion caused by metastatic angiosarcoma in the right lung. Tumor-infiltrating lymphocytes (TIL) in the pleural effusion were cultured and expanded in vitro in the continuous presence of recombinant interleukin 2 with periodic stimulation by CD3 antibody. The expanded TIL were administered intrapleurally seven times at 1- to 4-week intervals in combination with intravenous infusion of recombinant interleukin 2. A panel of T-cell clones was also obtained from TIL. Immunotherapy dramatically improved the patient's dyspnea and pleural effusion. A CD4+ T-cell clone and a CD8+ T-cell clone established from TIL had specific cytotoxicity to the tumor cells.
authors.affiliation: Department of Dermatology, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Furue
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Y
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: O
authors.initials: O
authors.lastname: Kobori
authors.forename: A
authors.initials: A
authors.lastname: Ihara
authors.forename: J
authors.initials: J
authors.lastname: Kitayama
authors.forename: M
authors.initials: M
authors.lastname: Minami
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003602:Cytotoxicity, Immunologic; D005260:Female; D006394:Hemangiosarcoma / Q000556:secondary* / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007267:Injections; D007275:Injections, Intravenous; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008209:Lymphedema / Q000628:therapy*; D016246:Lymphocytes, Tumor-Infiltrating; D015409:Mastectomy, Radical; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000628:therapy*; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000473:pathology / Q000628:therapy*; D013577:Syndrome
chemical_list: D007376:Interleukin-2