title: Paracoccidioidomycosis manifesting as oral lesions: clinical, cytological and serological investigation.
abstract: Paracoccidioidomycosis (South American blastomycosis) is a systemic mycosis which can be associated with oral lesions. This study on a group of 14 patients showed oral lesions mainly on the gingival or alveolar mucosa, with pulmonary involvement detectable on chest radiography in most. Microscopic detection of the fungus on a direct smear showed positive results in all 14 patients. Serological investigations including immunodiffusion, counterimmunoelectrophoresis and immunoblot were also positive in 100% of cases. The results suggest that direct smear together with serology may obviate the need for lesional biopsy for the diagnosis of oral paracoccidioidomycosis.
authors.affiliation: Department of Oral Diagnosis, Faculty of Odontology, UNESP, Araraquara, Brazil.
authors.forename: M R
authors.initials: MR
authors.lastname: Sposto
authors.forename: M J
authors.initials: MJ
authors.lastname: Mendes-Giannini
authors.forename: R A
authors.initials: RA
authors.lastname: Moraes
authors.forename: F C
authors.initials: FC
authors.lastname: Branco
authors.forename: C
authors.initials: C
authors.lastname: Scully
mesh_terms: D000328:Adult; D000368:Aged; D003378:Counterimmunoelectrophoresis; D005260:Female; D005656:Fungal Proteins / Q000032:analysis*; D006801:Humans; D015151:Immunoblotting; D005779:Immunodiffusion; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D010228:Paracoccidioides / Q000302:isolation & purification; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D011859:Radiography; D012424:Rural Population
chemical_list: D005656:Fungal Proteins