title: Structure of the mouse growth/differentiation factor 9 gene.
abstract: Using a mouse GDF-9 cDNA as a probe, over 20 kb of sequence encompassing the GDF-9 gene was isolated from a mouse 129SvEv genomic library. Sequence analysis of the exons, exon-intron boundaries, and 5'- and 3'-non-translated regions was used to establish the structure of the mouse GDF-9 gene. The GDF-9 gene is encoded by two exons separated by a 2.9 kb intron. Multiple putative transcription start sites are detected between 31 and 57 bp upstream of the start site of translation and a putative polyadenylation signal lies 342 bp 3' of the end of translation. Knowledge of the GDF-9 gene structure will enable us to further understand the role of GDF-9 in ovarian physiology and development.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
authors.forename: B
authors.initials: B
authors.lastname: Incerti
authors.forename: J
authors.initials: J
authors.lastname: Dong
authors.forename: G
authors.initials: G
authors.lastname: Borsani
authors.forename: M M
authors.initials: MM
authors.lastname: Matzuk
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D055430:Bone Morphogenetic Protein 15; D005260:Female; D055429:Growth Differentiation Factor 9; D006133:Growth Substances / Q000737:chemistry*; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010053:Ovary / Q000737:chemistry / Q000502:physiology
chemical_list: C525902:Bmp15 protein, mouse; D055430:Bone Morphogenetic Protein 15; C525898:Gdf9 protein, mouse; D055429:Growth Differentiation Factor 9; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins