Virilization of the voice in post-menopausal women due to the anabolic steroid nandrolone decanoate (Decadurabolin). The effects of medication for one year.
In a prospective study the effects on the voice of nandrolone decanoate super-imposed on cyclical hormonal replacement therapy (HRT) given to post-menopausal women suffering from a severe form osteoporosis were compared with the effects of HRT alone. Comparing the experimental group with the control group, after one year of medication in the experimental group a higher percentage of patients had: a lower fundamental frequency during speech, a loss of high frequencies and an increase in voice instability and creakiness. The lowering of the frequencies and the increase of instability can be explained by histological changes in the vocal cords and by problems in the adaptation to these histological changes.
Gerritsma
E J
EJ
Department of Phoniatrics, Oto-Rhino-Laryngology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Brocaar
M P
MP
Hakkesteegt
M M
MM
Birkenhäger
J C
JC
D000368:Aged; D045930:Anabolic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D004487:Edema / Q000139:chemically induced; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007828:Laryngoscopy; D008875:Middle Aged; D009277:Nandrolone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D010699:Phonation / Q000187:drug effects; D017698:Postmenopause; D011446:Prospective Studies; D013997:Time Factors; D014770:Virilism / Q000139:chemically induced*; D014831:Voice / Q000187:drug effects; D014832:Voice Disorders / Q000139:chemically induced*; D014833:Voice Quality / Q000187:drug effects
D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate