Differential regulation of IGF-I leader exon transcription.
We have shown that there is differential expression of the two IGF-I leader exons during physiological changes in GH and nutritional status in liver, with exon 2 being more responsive than exon 1. It may be that this exon is responsible for endocrine IGF-I synthesised in response to specific anabolic stimuli inducing subsequent whole body and skeletal muscle growth.
Pell
J M
JM
AFRC Babraham Institute, Cambridge, UK.
Gilmour
R S
RS
D000818:Animals; D001835:Body Weight; D005091:Exons; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D013006:Growth Hormone / Q000097:blood / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009752:Nutritional Status; D009929:Organ Size; D021382:Protein Sorting Signals / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis; D011986:Receptors, Somatotropin / Q000096:biosynthesis; D015183:Restriction Mapping; D012756:Sheep; D014158:Transcription, Genetic
D021382:Protein Sorting Signals; D012333:RNA, Messenger; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D017526:Receptor, IGF Type 1