Alteration of platelet benzodiazepine receptors by stress of war.
Mitochondrial benzodiazepine receptors play a major role in steroidogenesis. The authors determined plasma cortisol levels, platelet levels of mitochondrial benzodiazepine receptors, and anxiety and depression scores in 11 civilians exposed to the Persian Gulf war. The density of mitochondrial benzodiazepine receptors was 22% and 15% lower before and during the war, respectively, than 4 weeks after the end of the war. Relief of stress led to an increase in receptors, which correlated with the improvement in anxiety but not mood.
Weizman
R
R
Tel Aviv Community Mental Health Center, Israel.
Laor
N
N
Karp
L
L
Dagan
E
E
Reiss
A
A
Dar
D E
DE
Wolmer
L
L
Gavish
M
M
D001008:Anxiety Disorders / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry*; D003866:Depressive Disorder / Q000097:blood; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007557:Israel; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000032:analysis*; D013315:Stress, Psychological / Q000097:blood* / Q000175:diagnosis; D015854:Up-Regulation; D014857:Warfare
D011963:Receptors, GABA-A; D006854:Hydrocortisone