Interleukin-7, interleukin-8, soluble TNF receptor, and p53 protein levels are elevated in the serum of patients with Hodgkin's disease.
In a search for specific serum markers with prognostic impact, we evaluated the clinical significance of IL-4, IL-7, and IL-8 as well as TNF receptor levels and soluble p53 in the serum of patients with untreated Hodgkin's lymphoma (HD). No elevations were observed for IL-4, while IL-7 and IL-8 were elevated in 15/52 (29%) and 21/78 (27%) patients, respectively. Soluble TNF receptors were detected in 16/29 patients (55%), and were significantly elevated in 6 (21%). P53 was detected in 21/33 (64%) patients. While IL-7 levels, detectable sTNF receptors, and p53 were not correlated with other obvious parameters, elevated IL-8 levels were associated with the presence of B symptoms (p < 0.002) and occurred more often in the nodular sclerosis form than in other histological subtypes (p < 0.02). Further investigations that correlate these serum parameters with the situation at the cellular level of an involved tissue will help to elucidate the enigmatic biology of HD.
Trümper
L
L
Medizinische Klinik und Poliklinik, Innere I, University of Saarland, Homburg, Germany.
Jung
W
W
Dahl
G
G
Diehl
V
V
Gause
A
A
Pfreundschuh
M
M
D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D012995:Solubility; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
D015851:Interleukin-7; D016209:Interleukin-8; D018124:Receptors, Tumor Necrosis Factor; D016159:Tumor Suppressor Protein p53