Mechanisms of virus uncoating.
In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.
Greber
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Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Singh
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Helenius
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D000818:Animals; D002213:Capsid / Q000378:metabolism; D003600:Cytosol / Q000382:microbiology; D004705:Endocytosis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010447:Peptide Hydrolases / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000235:genetics
D011991:Receptors, Virus; D010447:Peptide Hydrolases