Hyperglycemia suppresses the adrenal medullary response to hypoxemia.
An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen breathing in both groups. In euglycemic rats, hypoxia increased epinephrine and norepinephrine by 650 and 320% above baseline, respectively. During hyperglycemia, (mean plasma glucose level 30.0 mM) epinephrine and norepinephrine rose only 119 and 104%, respectively. The catecholamine increase in the hyperglycemic rats was significantly attenuated in comparison to euglycemic controls (epinephrine, P = 0.0232; norepinephrine, P = 0.0079). These data demonstrate that acute hyperglycemia has the capacity to suppress the normal adrenal medullary response to hypoxemia.
Cohen
W R
WR
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461.
Deutsch
J
J
D000313:Adrenal Medulla / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D006943:Hyperglycemia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D007700:Kinetics; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D009638:Norepinephrine; D004837:Epinephrine