Dopamine D2 and serotonin S2 receptors in susceptibility to methamphetamine psychosis detected by positron emission tomography.
Positron emission tomography (PET) was used to assess the role of dopamine D2 receptors in the striatum and serotonin S2 receptors in the frontal cortex in the susceptibility to methamphetamine-induced psychosis. Subjects were six men who had previously experienced methamphetamine psychosis (methamphetamine subjects) and 10 age- and sex-matched control subjects. The radiotracer used was 11C-N-methylspiperone. Although binding availability, assessed by dynamic analysis, in the two regions did not differ between the two groups, the ratio of binding availability in the striatum to that in the frontal cortex significantly decreased in the methamphetamine subjects as compared with the control subjects. These findings suggest that an imbalance in the activity of these two receptors may be related to the susceptibility to methamphetamine psychosis.
Iyo
M
M
Division of Drug Dependence, National Institute of Mental Health, Chiba, Japan.
Nishio
M
M
Itoh
T
T
Fukuda
H
H
Suzuki
K
K
Yamasaki
T
T
Fukui
S
S
Tateno
Y
Y
D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D005625:Frontal Lobe / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011869:Radioligand Assay; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D013134:Spiperone / Q000031:analogs & derivatives; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D008694:Methamphetamine; D013134:Spiperone; C039167:3-N-methylspiperone