[Effect of REM sleep deprivation on the each seizure stage in feline amygdaloid kindling].
The effect of REM sleep deprivation (RD) on the each seizure stage in feline amygdaloid kindling (AM-K) was studied. RD for 12 hours (12-h RD) was performed by applying the platform procedure at stages 2 and 4, and immediately after RD the triggering threshold of each seizure stage and the duration of after discharge was measured. At stage 6, 12-h and 72-h RD were performed, and the generalized seizure triggering threshold (GST), the duration of after discharge, and the latency to generalized convulsive seizure (LGS) were measured. For the controls, a platform sufficiently large to allow a cat to lie down and sleep was used under the same conditions as those for RD (Non-RD). With the platform procedure employed in this study, the %REM decreased significantly to 2% of what it was before 12-h RD (p < 0.01). After the 12-h RD, the %REM and %S-2 increased significantly compared with those during the RD (p < 0.05-0.01), revealing a rebound phenomenon. After the 12-h RD, the %W-2 also showed a significant decrease (p < 0.05). The results were as follows: (1) The triggering seizure threshold of stage 2 after the 12-h RD showed a significant decrease (p < 0.01). Though the AD duration after RD prolonged than those after Non-RD, significant differences was not noted. (2) The triggering threshold and AD duration of stage 4 after 12-h RD showed no significant change. (3) GST, AD duration, LGS showed no significant change by 12-and 72-h RD. The results of present study led to the following conclusions: At stage 2 of AM-K, REM sleep increased temporarily, and consequently the REM pressure is elevated after RD so much that it lowers the triggering threshold at stage 2 of AM-K. On the other hand, at stages 4 and 6 of AM-K, REM sleep is temporarily decreased, and consequently the REM pressure is not elevated by RD so that the triggering threshold at stages 4 and 6 of AM-K were not lowered.
Kawahara
R
R
Department of Neuro-Psychiatry, Faculty of Medicine, Tottori University.
Hamazaki
Y
Y
Takeshita
H
H
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001143:Arousal / Q000502:physiology; D002415:Cats; D004558:Electric Stimulation; D005071:Evoked Potentials; D007696:Kindling, Neurologic; D012640:Seizures / Q000503:physiopathology*; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*