Prenylated proteins in regenerating rat liver.
During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylgeranylated proteins in pre-S phase is confirmed by an increased level of lamin A, B, C and of several GTP-binding proteins. These results suggest a relevance of both farnesylation and geranylgeranylation in this phase of the cell cycle.
Bruscalupi
G
G
Dipartimento di Biologia Cellulare e dello Sviluppo, Università La Sapienza, Roma, Italy.
Castellano
F
F
Sacco
S
S
Trentalance
A
A
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D034904:Lamin Type A; D034882:Lamins; D008115:Liver Regeneration; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism; D017368:Protein Prenylation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D034904:Lamin Type A; D034882:Lamins; D009687:Nuclear Proteins; D011506:Proteins; D019204:GTP-Binding Proteins; D016283:Proto-Oncogene Proteins p21(ras)