title: [Causes of organ failure in infection].
abstract: Causes of septic multiple organ failure are endotoxin induced mechanisms, exotoxin induced mechanisms and sepsis associated immunosuppression. Pharmacological intervention is limited. Therapy is restricted to aggressive surgical treatment in terms of eradication of the source of infection combined with supportive intensive care medicine. The prevention of systemic infections is mandatory. Approaches to new therapeutical concepts are outlined.
authors.affiliation: Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München.
authors.forename: H
authors.initials: H
authors.lastname: Bartels
authors.forename: J
authors.initials: J
authors.lastname: Stadler
authors.forename: W
authors.initials: W
authors.lastname: Barthlen
authors.forename: T
authors.initials: T
authors.lastname: Miedtke
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004731:Endotoxins / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000276:immunology* / Q000601:surgery; D010538:Peritonitis / Q000276:immunology / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012772:Shock, Septic / Q000276:immunology* / Q000601:surgery; D013530:Surgical Wound Infection / Q000276:immunology* / Q000601:surgery
chemical_list: D004731:Endotoxins
vernacular_title: Ursachen des Organversagens bei Sepsis.