title: A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34.
abstract: Hereditary haemorrhagic telangiectasia (HHT), or Osler-Weber-Rendu disease, is an autosomal dominant vascular dysplasia of unknown pathogenesis leading to 'widespread' dermal, mucosal and visceral telangiectases and recurrent haemorrhage. We have mapped the HHT gene, by linkage analysis, to markers on 9q33-34 in two large multi-generation families. Haplotype analysis and mapping of recombination breakpoints gives a 4 cM interval between D9S61 and D9S63 as the most likely location of the gene. The closest marker, D9S65, is estimated to be within 1 cM of the gene and shows a combined lod score of 11.41. Two potential candidate genes, COL5A1 and ZNF79, are also located within 9q33-34. These results provide a starting point for the eventual cloning of the HHT gene.
authors.affiliation: Department of Pediatrics, University of Michigan, Ann Arbor 48109.
authors.forename: M T
authors.initials: MT
authors.lastname: McDonald
authors.forename: K A
authors.initials: KA
authors.lastname: Papenberg
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: A A
authors.initials: AA
authors.lastname: Glatfelter
authors.forename: B B
authors.initials: BB
authors.lastname: Biesecker
authors.forename: E A
authors.initials: EA
authors.lastname: Helmbold
authors.forename: D S
authors.initials: DS
authors.lastname: Markel
authors.forename: A
authors.initials: A
authors.lastname: Zolotor
authors.forename: W C
authors.initials: WC
authors.lastname: McKinnon
authors.forename: J L
authors.initials: JL
authors.lastname: Vanderstoep
mesh_terms: D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D009838:Oligodeoxyribonucleotides; D010375:Pedigree; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D009838:Oligodeoxyribonucleotides