Linkage is excluded between Darier's disease and the Duffy blood group locus in five British families.
Munro and colleagues (Ann Génét, 1992, 35, 157-160) found small positive lod scores for linkage between the genes for Darier's disease and the Duffy blood locus in two large British families, with a maximum lod score in one family of 0.807 at theta = 0.0. The authors have examined five independent British pedigrees multiply affected by Darier's disease using highly polymorphic microsatellite DNA markers tightly linked to the Duffy locus. They were able to exclude close linkage between the Darier gene and CRP for theta < or = 0.16 and between the Darier gene and D1S104 for theta < or = 0.12. We conclude that the gene for Darier's disease does not lie close to the Duffy locus.
Craddock
N
N
Department of Psychological Medicine, University of Wales College of Medicine, Health Park, Cardiff, United Kingdom.
Burge
S
S
Parfitt
L
L
Owen
M
M
D002874:Chromosome Mapping; D007644:Darier Disease / Q000235:genetics*; D004375:Duffy Blood-Group System / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D006113:United Kingdom
D004375:Duffy Blood-Group System; D005819:Genetic Markers