title: X-linked laterality sequence in a family with carrier manifestations.
abstract: X-linked laterality sequence (XLLS) consists of situs inversus, complex cardiac defects, and alterations in the development of the spleen. We describe a family in which two male cousins had XLLS with caudal manifestations. In our family, the obligate carrier females had uterine septum and hypertelorism, which may be gene carrier manifestations.
authors.affiliation: Department of Clinical Genetics, Tampere University Hospital, Finland.
authors.forename: S P
authors.initials: SP
authors.lastname: Mikkilä
authors.forename: M
authors.initials: M
authors.lastname: Janas
authors.forename: R
authors.initials: R
authors.lastname: Karikoski
authors.forename: T
authors.initials: T
authors.lastname: Tarkkila
authors.forename: K O
authors.initials: KO
authors.lastname: Simola
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006330:Heart Defects, Congenital / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D012857:Situs Inversus / Q000235:genetics; D013154:Spleen / Q000002:abnormalities / Q000254:growth & development; D014960:X Chromosome