[Comparative observation of morphology and immunohistochemistry in rhabdomyosarcoma and fetal skeletal muscle].
The morphology of 50 rhabdomyosarcomas was compared with that of developing skeletal muscles from 20 fetuses and neonates. Vimentin, desmin, HHF-35 and myoglobin were used in labeling these specimens. We found that the consistent sequence, and intensity of tumor (express) markers related to the degree of morphological differentiation and analogous to the normal sequence in fetal myogenesis. According to the degree of tumor differentiation, we believe that different types of rhabdomyosarcoma comprise cells of variable degree of differentiation and are derived from primitive mesenchymal cells differentiating towards skeletal muscle. Histological typing of rhabdomyosarcoma is proposed to retain the WHO typing protocol while the best also being able to express the degree of differentiation.
Lai
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RQ
Guangzhou General Hospital of PLA.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003893:Desmin / Q000032:analysis; D005314:Embryonic and Fetal Development; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D009132:Muscles / Q000737:chemistry / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000737:chemistry / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis*
D003893:Desmin; D014746:Vimentin