Toxic oxygen metabolites and leukocytes in reperfusion injury. A review.
Toxic oxygen metabolites (TOM) are generated by activated leukocytes and ischemic tissue upon reperfusion, and are cardiotoxic in vitro. Generation of TOM during reperfusion in vivo has been measured directly and indirectly. TOM contribute to myocardial stunning, causing systolic and diastolic dysfunction. TOM may also play a role in the pathogenesis of reperfusion arrhythmias. It is uncertain if TOM cause cell death during reperfusion. Inhibition of TOM with antioxidants may be important for myocardial protection during cardiac surgery.
Valen
G
G
Department of Surgery, University of Tromsø, Norway.
Vaage
J
J
D006348:Cardiac Surgical Procedures; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D005609:Free Radicals; D017382:Reactive Oxygen Species; D013481:Superoxides; D006861:Hydrogen Peroxide; D010100:Oxygen