title: [Nightly myoclonus syndrome (NMS) and restless legs syndrome (RLS)--review and case report].
abstract: The paper gives a brief review of the existing literature concerning the nocturnal myoclonus syndrome (NMS). The clinical symptomatology, criteria for differential diagnosis and the relation to the restless legs syndrome (RLS) are discussed. Recently we investigated central dopamine receptor density with 123I-labeled 3'-iodo-6-methoxybenzamide (IBZM) (a highly selective CNS D2 dopamine receptor ligand) and single photon emission tomography (SPECT) in patients with NMS and found a reduced density of dopamine D2-receptors in the striatal structures, indicating a dopaminergic dysfunction in NMS and RLS. We present a report concerning a 58-year old female with NMS-associated insomnia and present IBZM SPECTs and hypnograms before and after a 3-month treatment with L-dopa and discuss the results with regard to pathophysiological theories.
authors.affiliation: Klinik und Poliklinik für Psychiatrie, Georg-August-Universität Göttingen.
authors.forename: J
authors.initials: J
authors.lastname: Staedt
authors.forename: G
authors.initials: G
authors.lastname: Stoppe
authors.forename: A
authors.initials: A
authors.lastname: Kögler
authors.forename: D L
authors.initials: DL
authors.lastname: Munz
authors.forename: G
authors.initials: G
authors.lastname: Hajak
authors.forename: U
authors.initials: U
authors.lastname: Staedt
authors.forename: H
authors.initials: H
authors.lastname: Riemann
authors.forename: E
authors.initials: E
authors.lastname: Rüther
mesh_terms: D004831:Epilepsies, Myoclonic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D011877:Radionuclide Imaging; D012148:Restless Legs Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013577:Syndrome
chemical_list: D007980:Levodopa
vernacular_title: Nächtliches Myoklonie-Syndrom (NMS) und Restless-Legs-Syndrom (RLS)--Ubersicht und Fallbeschreibung.