Controversies on the role of bone marrow transplantation for patients with hematopoietic malignancies.
Over the past decade, bone marrow transplantation has evolved as a treatment modality for patients with hematopoietic malignancies and for patients with responsive solid tumors. In this paper, I review (a) the indications for marrow transplantation, with emphasis on patients with hematopoietic malignancies, including acute and chronic leukemias and lymphomas; (b) the role of the donor, including the rapid expansion of compatible volunteer donors; (c) the role and design of preparative regimens; (d) the procurement of bone marrow, including marrow purging and T-cell depletion, and (e) the care of the transplant patient, including a discussion of the more commonly occurring complications.
Geller
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RB
Department of Medicine, Emory University School of Medicine, Atlanta, GA.
D000741:Anemia, Aplastic / Q000601:surgery; D016026:Bone Marrow Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D007951:Leukemia, Myeloid / Q000601:surgery*; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008223:Lymphoma / Q000601:surgery*; D011182:Postoperative Care; D014019:Tissue Donors