Myocardial energetics.
Inotropic alterations may alter contractile efficiency. Positive inotropic agents act mainly, if not exclusively, by increasing activation, which has very little effect on contractile efficiency. The metabolic effects of hypoxia may depress the contractile machinery directly. Acidosis is likely to decrease efficiency while an elevated phosphate, by itself, is likely to have little effect on efficiency.
Ford
L E
LE
Cardiology Section, University of Chicago, IL 60637.
D000818:Animals; D001696:Biomechanical Phenomena; D002316:Cardiotonic Agents / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D009132:Muscles / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*
D002316:Cardiotonic Agents