title: Inflammatory pain: the role of cytokines and its control by drugs which release nitric oxide.
abstract: We are progressing towards an understanding of the mechanism of peripherally acting analgesics. Knowledge of the participation of the cytokines in inflammatory hyperalgesia and the involvement of the arginine-NO-cGMP pathway in the mechanism of agents which directly down-regulate ongoing hyperalgesia may provide for better therapeutic approaches and permit the development of novel analgesics.
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: S H
authors.initials: SH
authors.lastname: Ferreira
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D001120:Arginine / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D016207:Cytokines / Q000502:physiology*; D015536:Down-Regulation; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D013565:Sympatholytics / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D016861:Cyclooxygenase Inhibitors; D016207:Cytokines; D013565:Sympatholytics; D009569:Nitric Oxide; D001120:Arginine; D006152:Cyclic GMP