title: [Extra-mammary Paget's disease. An HPV-correlated neoplasia?].
abstract: Eight cases of Paget's disease of the vulva and anogenital region are presented. Seven cases presented intraepithelial lesions and only one showed superficial intraepidermal diffusion. The average age of the patients in our series was 58.8 years. In all cases histochemical and immunohistochemical reactions were positive, except for the CEA reaction (only one case was positive). Specimens from our series were tested for presence of HPV 6, 11, 16, 18, 31, 33, 35 by in situ DNA hybridization. All cases were negative. Paget's disease, at the moment, is the only tumor of the low female genital tract non HPV-associated. Recurrences are very frequent even many years after radical surgery treatment.
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze.
authors.forename: G L
authors.initials: GL
authors.lastname: Taddei
authors.forename: D
authors.initials: D
authors.lastname: Moncini
authors.forename: A
authors.initials: A
authors.lastname: Cattaneo
authors.forename: P
authors.initials: P
authors.lastname: Carli
authors.forename: G
authors.initials: G
authors.lastname: Baroni
mesh_terms: D000368:Aged; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000382:microbiology*; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000382:microbiology*; D010502:Perineum; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000382:microbiology*; D014846:Vulvar Neoplasms / Q000382:microbiology*
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral
vernacular_title: La malattia di Paget extramammaria. Neoplasia HPV correlata?