Deoxyspergualin--a novel immunosuppressant.
DSG appears to have a unique, although as yet undefined, mechanism of action and may be a useful immunosuppressive agent. Because DSG is effective in reducing preformed antibodies in the xenograft situation, it may have a significant advantage in ABO-incompatible grafts in transplant recipients with high panel-reactive antibodies. Most important, DSG may have a definitive role in immunosuppressive therapy for pancreatic grafts.
Jindal
R M
RM
Transplantation Services, University Hospital, Boston, MA.
Tepper
M A
MA
Soltys
K
K
Cho
S I
SI
D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016035:Pancreas Transplantation; D014181:Transplantation Immunology
D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus