title: Structural aspects of actin-binding proteins.
abstract: The three-dimensional structures of myosin subfragment 1 (S1), gelsolin segment 1 complexed with alpha-actin, villin fragment 14T, Acanthamoeba profilin-I, and bovine profilin complexed with beta-actin were completed last year. Together, they expand our understanding of the structural organization of actin-binding proteins. In addition, the segment 1 and bovine profilin complexes provide atomic-level descriptions of their interfaces with actin.
authors.affiliation: Department of Chemistry, Henry H Hoyt Laboratory, Princeton University, NJ 08544.
authors.forename: M D
authors.initials: MD
authors.lastname: Rozycki
authors.forename: J C
authors.initials: JC
authors.lastname: Myslik
authors.forename: C E
authors.initials: CE
authors.lastname: Schutt
authors.forename: U
authors.initials: U
authors.lastname: Lindberg
mesh_terms: D000199:Actins / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D018260:Gelsolin / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015879:Myosin Subfragments / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary
chemical_list: D000199:Actins; D002352:Carrier Proteins; D018260:Gelsolin; D008840:Microfilament Proteins; D015879:Myosin Subfragments; C026615:villin