title: Glycated haemoglobin predicts progression to diabetes mellitus in Pima Indians with impaired glucose tolerance.
abstract: Glycated haemoglobin could offer several practical advantages over the OGTT for assessing glucose metabolism. Initial cross-sectional studies (1983-1985) on 381 subjects (mostly Pima Indians) described the relationship between HbA1c (a specific glycated Hb) and the OGTT. We performed follow-up OGTTs and HbA1c measurements on 257 of these same subjects 1.6-6.1 years later. Subjects were again grouped according to both the result of the OGTT (normal, IGT or diabetes, by WHO criteria) and HbA1c result (normal or elevated based on mean +/- 1.96 SD of normal). Of 66 subjects with IGT at baseline, 47 (71%) had normal HbA1c and 19 (29%) had elevated HbA1c. Twenty-six (39%) of these subjects had diabetes at follow-up. Of these subjects with IGT, a significantly greater percentage of subjects with elevated HbA1c at baseline (68%) showed worsening to diabetes than those with a normal HbA1c (28%); (chi-square = 7.8, df = 1, p < 0.01). Thus, in subjects with IGT, glycated Hb may be a useful predictor of progression to diabetes.
authors.affiliation: Department of Pathology, University of Missouri, School of Medicine, Columbia 65212.
authors.forename: R R
authors.initials: RR
authors.lastname: Little
authors.forename: J D
authors.initials: JD
authors.lastname: England
authors.forename: H M
authors.initials: HM
authors.lastname: Wiedmeyer
authors.forename: R W
authors.initials: RW
authors.lastname: Madsen
authors.forename: D J
authors.initials: DJ
authors.lastname: Pettitt
authors.forename: W C
authors.initials: WC
authors.lastname: Knowler
authors.forename: D E
authors.initials: DE
authors.lastname: Goldstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona; D003920:Diabetes Mellitus / Q000097:blood* / Q000208:ethnology*; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood* / Q000208:ethnology*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D006442:Glycated Hemoglobin