Cell signalling and motile activity.
The actin cytoskeleton is a remarkably dynamic structure in non-muscle cells which responds to cell stimulation by a variety of cytokines. A paradigm for such cytokine-induced reorganization of the actin superstructure is the actin response to growth factor of the EGF/PDGF family. This paper reviews the role of the polyphosphoinositide-metabolism, small GTP-binding proteins and profilin in the reorganization of the actin cytoskeleton in cells activated by growth factors.
Heldman
A W
AW
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Goldschmidt-Clermont
P J
PJ
D000199:Actins / Q000502:physiology; D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D003285:Contractile Proteins; D016207:Cytokines / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D008840:Microfilament Proteins / Q000502:physiology; D051304:Profilins
D000199:Actins; D003285:Contractile Proteins; D016207:Cytokines; D008840:Microfilament Proteins; D051304:Profilins; D019204:GTP-Binding Proteins