Aspirin-like drugs inhibit neuronally evoked responses in isolated guinea-pig ileum.
The acute effects of non steroidal anti-inflammatory drugs (NSAIDs) were studied on guinea-pig ileum isolated preparation. Two cyclo-oxygenase inhibitors, aspirin and indomethacin, and two NSAID devoid of this effect, salicylic acid and benzydamine, were injected into the bath 1 min before PGE1 or CCK-8. All drugs tested elicited a dose-related inhibition of the neuronally evoked contractile responses to submaximal dose of PGE1 and CCK-8. These drugs depressed also the opioid system(s) activated by PGE1 or CCK-8. These results indicate that the inhibition of neuronally evoked response is a common mechanism of NSAIDs. This mechanism may have an important role on analgesic and anti-inflammatory action of these drugs.
Valeri
P
P
Istituto di Farmacologia e Farmacognosia, Università degli Studi La Sapienza, Rome, Italy.
Morrone
L A
LA
Romanelli
L
L
Amico
M C
MC
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology; D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001591:Benzydamine / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000294:innervation; D007213:Indomethacin / Q000494:pharmacology; D007551:Isotonic Contraction / Q000187:drug effects; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid; D012844:Sincalide / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011957:Receptors, Opioid; D012459:Salicylates; D009270:Naloxone; D001591:Benzydamine; D000527:Alprostadil; D012844:Sincalide; D000109:Acetylcholine; D020156:Salicylic Acid; D001241:Aspirin; D007213:Indomethacin