title: 31P-magnetic resonance spectroscopy in migraine without aura.
abstract: We investigated 22 patients with migraine without aura, all drug-free and in headache-free periods, by means of 31P-magnetic resonance spectroscopy (MRS) of brain and muscle. Brain 31P-MRS showed significantly low phosphocreatine, increased adenosine diphosphate, and decreased phosphorylation potential. There was a slow rate of phosphocreatine recovery after exercise in the muscle of 12 of 22 patients. Energy metabolism is abnormal in migraine without aura, as previously demonstrated in patients with migraine stroke and migraine with aura.
authors.affiliation: Institute of Neurology, Medical Pathology Institute D. Campanacci, University of Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Montagna
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: L
authors.initials: L
authors.lastname: Monari
authors.forename: G
authors.initials: G
authors.lastname: Pierangeli
authors.forename: P
authors.initials: P
authors.lastname: Parchi
authors.forename: R
authors.initials: R
authors.lastname: Lodi
authors.forename: S
authors.initials: S
authors.lastname: Iotti
authors.forename: C
authors.initials: C
authors.lastname: Frassineti
authors.forename: P
authors.initials: P
authors.lastname: Zaniol
authors.forename: E
authors.initials: E
authors.lastname: Lugaresi
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus; D013997:Time Factors
chemical_list: D010725:Phosphocreatine; D010758:Phosphorus