Protection of gerbils from amebic liver abscess by immunization with a recombinant protein derived from the 170-kilodalton surface adhesin of Entamoeba histolytica.
The protozoan parasite Entamoeba histolytica causes extensive morbidity and mortality worldwide through intestinal infection and amebic liver abscess. Here we show that vaccination of gerbils, a standard model for amebic liver abscess, with recombinant proteins derived from the 170-kDa galactose-binding adhesin of E. histolytica and the serine-rich E. histolytica protein or a combination of the two recombinant antigens provides excellent protection against subsequent hepatic challenge with virulent E. histolytica trophozoites.
Zhang
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Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Stanley
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SL
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D004748:Entamoeba histolytica / Q000276:immunology*; D005260:Female; D005849:Gerbillinae; D005982:Glutathione Transferase / Q000276:immunology; D008101:Liver Abscess, Amebic / Q000517:prevention & control*; D058619:Maltose-Binding Proteins; D008970:Molecular Weight; D015800:Protozoan Proteins / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*
D002352:Carrier Proteins; D058619:Maltose-Binding Proteins; D015800:Protozoan Proteins; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; D005982:Glutathione Transferase