Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.
Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) genes encode transcription factors belonging to the orphan subfamily of the steroid/thyroid hormone receptor superfamily. Two COUP-TF counterparts have been cloned from mouse. In an attempt to study the function of these genes in the developing central nervous system (CNS), the spatiotemporal expression patterns of the two mouse genes have been examined by in situ hybridization. Both genes are widely expressed in the developing CNS, with patterns that are overlapping yet distinct from each other. The differential expression of murine COUP-TFI and -II in the diencephalon is striking in that high levels of expression from each gene are confined to specific segmental compartments--the neuromeres. Our results suggest that murine COUP-TFs may play important roles in the development and differentiation of the CNS, including the specification of diencephalic neuromeres.
Qiu
Y
Y
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.
Cooney
A J
AJ
Kuratani
S
S
DeMayo
F J
FJ
Tsai
S Y
SY
Tsai
M J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D051838:COUP Transcription Factor I; D002454:Cell Differentiation; D002645:Chickens; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D004027:Diencephalon / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D009928:Organ Specificity; D010047:Ovalbumin / Q000096:biosynthesis* / Q000235:genetics*; D011401:Promoter Regions, Genetic; D015347:RNA Probes; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics*
D051838:COUP Transcription Factor I; D004268:DNA-Binding Proteins; C497589:NR2F1 protein, human; C497590:Nr2f1 protein, mouse; D015347:RNA Probes; D014157:Transcription Factors; D010047:Ovalbumin