title: A comparison of the serum concentration time-curves of amikacin-administered patients before and after open heart surgery.
abstract: The effects of open heart surgery on amikacin concentration time-curves were investigated in eight patients who were scheduled for open heart surgery at a Thoracic and Cardiovascular Surgery Department. A 500 mg single dose of amikacin was administered parenterally to the volunteers pre- and postoperatively and the serum concentration time-curves were compared. Serum amikacin levels after pre-operative intramuscular (IM) administration did not reach therapeutic values. By comparison, preoperative and postoperative IM or intravenously (IV) administration resulted in therapeutic serum amikacin levels. It was concluded that IM administration preoperatively was not appropriate. Serum levels of amikacin were also shown to fall below therapeutic values 8 h after administration. It is recommended that dosing intervals with amikacin should not exceed 8 h.
authors.affiliation: Department of Pharmacology, Dokuz Eylul University Medical Faculty, Izmir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Guven
authors.forename: O
authors.initials: O
authors.lastname: Oto
authors.forename: U
authors.initials: U
authors.lastname: Acikel
authors.forename: S
authors.initials: S
authors.lastname: Gidener
authors.forename: S
authors.initials: S
authors.lastname: Apaydin
authors.forename: E
authors.initials: E
authors.lastname: Silistrel
authors.forename: A
authors.initials: A
authors.lastname: Gelal
mesh_terms: D000328:Adult; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011292:Premedication
chemical_list: D000583:Amikacin