Big endothelin in spontaneous intracerebral hemorrhage.
Plasma big endothelin (BE) levels were studied in 17 patients during the first 2 weeks following spontaneous intracerebral hemorrhage (ICH). Three patients had experienced an infratentorial hemorrhage of the pons and cerebellum. The group of 14 patients with supratentorial hemorrhage presented with 8 hematomas of the putamen, 4 of the capsula interna and 2 in the thalamus. Significant elevations of BE during the first 2 weeks after the initial ICH, significant differences between the different localisations and between patients with different prognoses were not apparent (mean BE level: 2.95 +/- 1.39, control group: 2.68 +/- 1.29 fmol/ml). These results support the theory that endothelins do not play a significant pathophysiological role in acute severe ICH.
Hamann
G F
GF
Department of Neurology, University of the Saarland, Homburg, FRG.
Isenberg
E
E
Strittmatter
M
M
Stoll
M
M
Keshevar
T
T
Moili
R
R
Schimrigk
K
K
D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis; D002552:Cerebral Ventricles / Q000503:physiopathology; D019332:Endothelin-1; D016232:Endothelins / Q000097:blood*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D011863:Radioimmunoassay; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000175:diagnosis
D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors