Characterization of anergy to the superantigen Staphylococcus enterotoxin B.
In vivo administration of superantigens leads to activation and subsequent depletion or anergy of T cells expressing defined V beta-T cell receptors (TCR). Superantigens have therefore become intensively studied tools for examining parameters of immunoregulation and they may represent model antigens for pathogenic agents. An HIV-encoded superantigen has for example been implicated in the dramatic loss of helper T cells in AIDS. We investigated the response of V beta 8+ T cells in mice after primary and secondary exposure to the superantigen Staphylococcus Enterotoxin B (SEB).
Dannecker
G
G
Department of Hematology/Oncology, Children's University Hospital, Tübingen, Germany.
Schultz
H
H
Mecheri
S
S
Sappler
G
G
Clarke
K
K
Niethammer
D
D
Hoffmann
M K
MK
D000818:Animals; D004768:Enterotoxins / Q000008:administration & dosage / Q000276:immunology*; D007108:Immune Tolerance; D007117:Immunization, Secondary; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000008:administration & dosage; D016176:T-Lymphocyte Subsets / Q000276:immunology
D004768:Enterotoxins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens; C031818:enterotoxin B, staphylococcal