Hypocholesterolemic effects of mixture Da Huai on experimental rats and treatment of a homozygous FH child.
This study observes the hypocholesterolemic effects of Mixture Da Huai--a drug of enhancing monocyte macrophage system--on experimental rats, and the treatment of a homozygous familial hypercholesterolemia (FH) child. The results show that TC, VLDL-C and LDL-C in Mixture Da Huai group were significantly reduced and HDL-C was significantly increased. Fractional clearance rates for 125I-GLC-LDL, and the 125I-GLD-LDL uptake of rat peritoneal macrophages were significantly increased. Excretions of total sterol and acidic sterol in feces were also increased. After treatment for 3 months, serum TC and LDL-C of a homozygous FH child were significantly decreased. Tendon and cutaneous xanthomas were limited. This study indicates that by promoting the monocyte macrophage system to degrade LDL, a promising prevention and treatment of hypercholesterolemia and atherosclerosis might be provided, especially in the treatment of homozygous FH.
Liu
K
K
Department of Pathophysiology, Xuzhou Medical College, Jiangsu, People's Republic of China.
Li
C F
CF
Cai
H J
HJ
Shen
D Z
DZ
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013261:Sterols / Q000032:analysis
D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D013261:Sterols; C087224:da huai mixture; D002784:Cholesterol