Acute myeloid leukaemia in a patient with Seckel syndrome.
We report a female patient with Seckel syndrome who developed acute myeloid leukaemia at the age of 26 years. Analysis of bone marrow chromosomes showed an abnormal clone with abnormalities involving multiple chromosomes, including monosomy 7, trisomy 8, trisomy 11, and loss of the long arm of chromosome 5. After treatment with chemotherapy, the patient experienced severe toxicity with profound bone marrow aplasia and died of pneumonia two months later. We suggest that patients with Seckel syndrome may be at risk of developing myelodysplasia and acute myeloid leukaemia. They may also have poor tolerance to cytotoxic therapy.
Hayani
A
A
Department of Pediatrics, Loyola University Medical Center, University of Chicago Stritch School of Medicine, Maywood, IL 60153.
Suarez
C R
CR
Molnar
Z
Z
LeBeau
M
M
Godwin
J
J
D000015:Abnormalities, Multiple; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D002872:Chromosome Deletion; D005260:Female; D006257:Head / Q000002:abnormalities; D006801:Humans; D008607:Intellectual Disability; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000209:etiology*; D008831:Microcephaly; D013577:Syndrome; D014314:Trisomy
D000970:Antineoplastic Agents