Marchiafava-Bignami disease. Premortem diagnosis of an acute case utilizing magnetic resonance imaging.
Marchiafava-Bignami disease is a rare demyelinating disease involving the corpus callosum and other central white matter tracts. In the patient described here, the disease produced extensive demyelination of the corpus callosum and deep cerebral white matter. This widespread demyelination, confirmed pathologically, was associated with a fulminant fatal course. The magnetic resonance imaging appearance is quite suggestive of Marchiafava-Bignami disease and plays an important role in the premortem diagnosis.
Marjama
J
J
Department of Neurology, University of Arizona Health Sciences Center, Tucson 85724.
Yoshino
M T
MT
Reese
C
C
D000208:Acute Disease; D000328:Adult; D000437:Alcoholism / Q000150:complications*; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology; D003337:Corpus Callosum / Q000473:pathology; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male