title: Effects of dogfish urotensin II on lipid mobilization in the fasted dogfish, Scyliorhinus canicula.
abstract: Previous studies, both in vitro and in vivo, have shown that urotensin II stimulates hepatic release of nonesterified fatty acids in teleost fish, but the effects of the peptide on lipid mobilization in elasmobranchs are unknown. Infusions of synthetic dogfish urotensin II (40 pmol/min/kg for 30 min followed by 400 pmol/min/kg for 30 min) into the first afferent gill artery of the fasted, unrestrained dogfish, Scyliorhinus canicula (n = 6), produced no significant change in the circulating concentrations of acetoacetate, 3-hydroxybutyrate, and triacylglycerols. Circulating nonesterified fatty acids were undetectable (< 0.1 mmol/liter) both before and after the urotensin II infusions. There was no significant change in the circulating concentrations of glucose and lactate during either the low- or the high-dose infusions. The data support the hypothesis that lipid is converted primarily to ketone bodies in the livers of elasmobranch fish and do not indicate a role for urotensin II in regulating either lipid or glycogen mobilization.
authors.affiliation: Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178.
authors.forename: J M
authors.initials: JM
authors.lastname: Conlon
authors.forename: L
authors.initials: L
authors.lastname: Agius
authors.forename: K
authors.initials: K
authors.lastname: George
authors.forename: M M
authors.initials: MM
authors.lastname: Alberti
authors.forename: N
authors.initials: N
authors.lastname: Hazon
mesh_terms: D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood; D000595:Amino Acid Sequence; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004284:Dogfish / Q000378:metabolism*; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006885:Hydroxybutyrates / Q000097:blood; D007657:Ketone Bodies / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D014280:Triglycerides / Q000097:blood; D014579:Urotensins / Q000494:pharmacology*
chemical_list: D000090:Acetoacetates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D007773:Lactates; D014280:Triglycerides; D014579:Urotensins; D019344:Lactic Acid; C016635:acetoacetic acid; C029677:urotensin II; D020155:3-Hydroxybutyric Acid