Giant marginal ulcer.
Marginal ulcer is a well-known complication of gastroenterostomy. It occurs in 3% of patients post-Billroth II subtotal gastrectomy; it occurs in less than 1% if truncal vagotomy is included but in up to 30% of patients with gastroenterostomy without vagotomy. These ulcers occur at the anastomosis, but always on the jejunal side, and are known to develop complications of their own--e.g., intractable pain; hemorrhage, obstruction, perforation, and fistula formation. Prior to the advent of upper-GI endoscopy the main method of diagnosis was by history and upper GI series but the accuracy of the upper-Gi series was about 50% or less. Now that upper-GI endoscopy is available, the accuracy of diagnosis is 95% or better. Since truncal vagotomy has been widely adopted as an integral part of gastric surgery--e.g., antrectomy, hemigastrectomy, subtotal gastrectomy, and gastroenterostomy--the incidence of marginal ulcer has declined. The use of cimetidine, ranitidine, famotidine, omeprazole, sucralfate, and antacids has improved the medical management of duodenal ulcer to such a degree that in recent years there is much less need for surgical intervention and thus the incidence of marginal ulcer has declined even more. In addition, the H-2 blockers and omeprazole can be used in patients with marginal ulcer and achieve healing; therefore complications that so frequently required surgical intervention are much less frequent.(ABSTRACT TRUNCATED AT 250 WORDS)
Gowen
G F
GF
Department of Surgery, Pennsylvania Hospital, School of Medicine, University of Pennsylvania, Philadelphia 19106.
Campbell
R E
RE
McFarland
M M
MM
Alman
B A
BA
D000714:Anastomosis, Surgical; D001630:Bezoars / Q000209:etiology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005763:Gastroenterostomy / Q000009:adverse effects*; D006801:Humans; D007579:Jejunal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012008:Recurrence; D013270:Stomach; D014839:Vomiting / Q000209:etiology