title: Deep vein thrombosis in a 13-year-old boy with hereditary protein S deficiency and a review of the pediatric literature.
abstract: We report a 13-year-old boy with hereditary deficiency of protein S, who developed a deep vein thrombosis of the lower limb after a varicella with severe cutaneous lesions. Hereditary protein S deficiency is an established cause of thrombophilia; however thrombotic events are seldom described in pediatric patients. A review of previous literature revealed 35 cases, 16 girls and 19 boys, with a first episode below of the age of 18 years old (x = 10y). The 57% of the patients had venous thrombosis, 20% arterial thrombosis, and 14% both and in 9% the type of thrombosis was not reported. Predisposing factors were referred in only 12 cases. The deficiencies can be classified as type I in 25 patients and type III in 8.
authors.affiliation: Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Blanco
authors.forename: M
authors.initials: M
authors.lastname: Bonduel
authors.forename: L
authors.initials: L
authors.lastname: Peñalva
authors.forename: M
authors.initials: M
authors.lastname: Hepner
authors.forename: M
authors.initials: M
authors.lastname: Lazzari
mesh_terms: D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018455:Protein S Deficiency; D013924:Thrombophlebitis / Q000209:etiology*