Unusual combination of insulin-dependent diabetes mellitus with transient-pituitary-isolated gonadotropin deficiency.
We report a 27-year-old man with insulin-dependent diabetes mellitus and transient-pituitary-isolated gonadotropin deficiency. He had typical diabetic symptoms, and loss of libido of a 6-month duration. Although antibodies to islet cells or islet cell surface were not detected in his sera, daily urinary excretion of c-peptide immunoreactivity was extremely low, and antibodies to the pituitary AtT-20 cell were detected. The plasma responses of gonadotropin to a single and a repetitive luteinizing hormone-releasing hormone were extremely low, whereas testosterone concentrations in the serum and urine were low normal. After 6 months, the gonadotropin deficiency and loss of libido were not detected and antibodies to the AtT-20 cell was negative. We suspected that both insulin-dependent diabetes mellitus and transient-gonadotropin-deficiency might be an autoimmune mechanism.
Ishida
Y
Y
Division of Endocrinology and Metabolism, Hyogo Medical Center for Adults, Akashi.
Kazumi
T
T
Hotta
K
K
Maeda
T
T
Yoshida
M
M
Shii
K
K
Baba
S
S
D000328:Adult; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000503:physiopathology*; D007172:Erectile Dysfunction / Q000209:etiology; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D008297:Male
D006065:Gonadotropins, Pituitary