Oral cytomegalovirus infection in an unrelated bone marrow transplantation with possible mediation by graft-versus-host disease and the use of cyclosporin-A.
Graft-versus-host disease remains as a significant sequela in allogeneic bone marrow transplantation patients. Reports of oral presentations of cytomegalovirus infection in this patient population are rare. Although the usual manifestation of oral cytomegalovirus is mucosal ulceration, we report a case that we believe reflects a dynamic among graft-versus-host disease, cytomegalovirus, and the use of cyclosporin A, commonly used as an immunosuppressive agent in bone marrow transplantation.
LeVeque
F G
FG
Harper Hospital, Detroit, MI 48201.
Ratanatharathorn
V
V
Dan
M E
ME
Orville
B
B
Coleman
D N
DN
Turner
S
S
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D007124:Immunoenzyme Techniques; D008224:Lymphoma, Follicular / Q000628:therapy; D009059:Mouth Diseases / Q000150:complications / Q000382:microbiology*; D009061:Mouth Mucosa / Q000382:microbiology / Q000473:pathology; D014060:Tongue Diseases / Q000150:complications / Q000382:microbiology; D014456:Ulcer / Q000382:microbiology
D016572:Cyclosporine