Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus.
The effect of corticosterone on 5-HT1A receptor mRNA expression in different hippocampal cell fields was studied by in situ hybridisation. One week after adrenalectomy or chronic corticosterone treatment, the 5-HT1A receptor mRNA showed a negative, but not linear, correlation with plasma corticosterone levels over a wide concentration range, specifically in the dentate gyrus. The data suggest an involvement of the mineralocorticoid receptor in the regulation of the 5-HT1A receptor mRNA and a possible synergistic effect of additional glucocorticoid receptor activation.
Meijer
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Leiden/Amsterdam Center for Drug Research, Sylvius Laboratories, The Netherlands.
de Kloet
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D000315:Adrenalectomy; D000818:Animals; D001345:Autoradiography; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D011985:Receptors, Serotonin / Q000096:biosynthesis* / Q000235:genetics; D044263:Receptors, Serotonin, 5-HT1
D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D003345:Corticosterone