[The usefulness of serum antibody to Epstein-Barr virus-specific DNAase (EDAb) in early detection of nasopharyngeal carcinoma].
During a mass screening of nasopharyngeal carcinoma (NPC) in Guangzhou area, 224 out of 5030 normal individuals were found to be EDAb positive (anti-enzyme rate > or = 30%). Seventy seven of the 224 gave high antibody titter (anti-enzyme rate > 50%). After a 52-month follow-up, 14 NPC patients were picked up. All but one were from EDAb positive individuals and 9 patients were from those with high antibody titter. The relative risks of developing NPC were 279 and 562 for EDAb positive individuals and for those with high antibody titter, respectively. On the outpatient department, 98 patients with negative biopsy of the nasopharynx for cancer were divided into EDAb positive (n = 44) and negative (n = 54) groups. Within 3-month follow up, 39 NPC were diagnosed by multiple biopsies. 34 cases were from the first group (77.3%) while only 5 from the second group (9.3%). The occurrence rate of NPC in the first group was 8.3 fold as high as that in the second group. The results of the present studies indicate that EDAb assay is useful for early detection of NPC.
Huang
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Cancer Institute, Sun Yat-Sen University of Medical Sciences, Guangzhou.
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D003851:Deoxyribonucleases / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*
D000914:Antibodies, Viral; D003851:Deoxyribonucleases