title: Cutaneous crystalline deposits in myeloma.
abstract: BACKGROUND
  Myeloma is a plasma cell malignancy that usually presents with systemic manifestations or symptoms related to bone involvement. We describe the first case of crystalline protein deposition in the skin as the initial manifestation of myeloma.
  
  
  METHODS
  Crystals were found mainly in the extracellular space in the dermis of both involved and uninvolved skin in the absence of plasma cell infiltration. Crystals were also found in conjunctival tissue and bone marrow.
  
  
  CONCLUSIONS
  We have described a unique case of myeloma that presented as facial and eyelid swelling. There were crystalline deposits in the skin and conjunctivae, but mechanisms of crystal formation and the factors causing local deposition were not established. However, treatment of the underlying disorder leads to resolution of the cutaneous features of crystal deposition.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London, England.
authors.forename: R E
authors.initials: RE
authors.lastname: Jenkins
authors.forename: E
authors.initials: E
authors.lastname: Calonje
authors.forename: H
authors.initials: H
authors.lastname: Fawcett
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
authors.forename: E
authors.initials: E
authors.lastname: Wilson-Jones
mesh_terms: D001706:Biopsy; D003460:Crystallization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*