title: Effects of a prolonged administration of valepotriates in rats on the mothers and their offspring.
abstract: Valeriana officinalis L. (Valerianaceae) is widely known to be associated with sedative properties. The effects of a valepotriates mixtures on mothers and progeny were evaluated in rats. A 30-day administration of valepotriates did not change the average length of estral cycle, nor the number of estrous phases during this period. Also, there were no changes on the fertility index. Fetotoxicity and external examination studies did not show differences, although internal examination revealed an increase in number of retarded ossification after the highest doses employed--12 and 24 mg/kg. No changes were detected in the development of the offspring after treatment during pregnancy. As for temperature, valepotriates caused a hypothermizant effect after administration by the intraperitoneal route but not after oral administration. Generally, the valepotriates employed induced some alterations after administration by the intraperitoneal route, but doses given orally were innocuous to pregnant rats and their offspring.
authors.affiliation: Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Tufik
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: M de L
authors.initials: Mde L
authors.lastname: Seabra
authors.forename: L L
authors.initials: LL
authors.lastname: Lobo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007274:Injections, Intraperitoneal; D039823:Iridoids; D008431:Maternal-Fetal Exchange; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000633:toxicity*; D011714:Pyrans / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D039823:Iridoids; D010936:Plant Extracts; D011619:Psychotropic Drugs; D011714:Pyrans; C030127:valtrate