[Effects of monoclonal antibodies to laminin receptors on the invasive and metastatic behaviors of human lung carcinoma cells].
The effects of laminin receptor monoclonal antibodies (McB1) on the cell growth, and the invasive and metastatic behaviors of human giant cell carcinoma (PG) as well as adenocarcinoma (PAa) of lung were investigated by using cell culture, modified microinvasion assay and experimental metastasis assay techniques. The results showed that McB1 could inhibit adhesion and spreading of PG and PAa cells on the laminin substrate. The monoclonal antibodies were able to induce alterations of the morphology and microtubule structure of the tumor cells. The growth and invasive abilities were inhibited, and the experimental metastasis of PG cells could be abolished by McB1. It is suggested that laminin receptors may play an important role in the process of tumor invasion and metastasis, and the related monoclonal antibodies may contribute to the therapy of tumor metastasis.
Wu
S
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Department of Pathology, Beijing Medical University.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D000911:Antibodies, Monoclonal; D018286:Carcinoma, Giant Cell / Q000473:pathology*; D002448:Cell Adhesion; D002455:Cell Division; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D017474:Receptors, Laminin / Q000276:immunology*; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D017474:Receptors, Laminin