Antitumor effects of rhodium (II) complexes on mice bearing Ehrlich tumors.
Rhodium (II) trifluoroacetate (TFARh), rhodium (II) trifluoroacetate adduct with sulfadiazine (TFARh.Sd) and rhodium (II) acetate adduct with sulfisoxazole (RhSx) were tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and for viability of Ehrlich tumor cells in culture. At ip doses up to 60 mumol/kg (40-70 and 59 mg/kg, respectively), these compounds had no toxic effects up to 14 days. At ip doses of 10 mumol kg-1 day-1 for 5 days, TFARh and TFARh.Sd significantly increased the survival rate of mice bearing Ehrlich ascites cells (probability of survival to the end of 34th day, controls = 0.23, TFARh = 0.85, TFARh.Sd = 0.74). No significant effect was observed for RhSx. In vitro, these rhodium complexes at 40 microM significantly increased the number of dead cells in cultured Ehrlich tumor cells.
Reibscheid
E M
EM
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Zyngier
S
S
Maria
D A
DA
Mistrone
R J
RJ
Sinisterra
R D
RD
Couto
L G
LG
Najjar
R
R
D000085:Acetates / Q000008:administration & dosage; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000401:mortality; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D008807:Mice, Inbred BALB C; D012238:Rhodium / Q000494:pharmacology*; D013411:Sulfadiazine / Q000008:administration & dosage; D013444:Sulfisoxazole / Q000008:administration & dosage; D015996:Survival Rate; D013997:Time Factors; D014269:Trifluoroacetic Acid / Q000008:administration & dosage
D000085:Acetates; D013411:Sulfadiazine; D013444:Sulfisoxazole; D012238:Rhodium; D014269:Trifluoroacetic Acid