[Genetic and immunologic studies after space flight].
The effect of spaceflight on lymphocytes of the peripheral blood was investigated in the Austrian cosmonaut flying the Austro-Soviet mission Austromir. Blood was sampled before and after flight, and the following parameters studied: quantities of lymphocytic subsets (T cells, helper cells, suppressor cells, B cells and natural killer cells); mitogenic stimulation of lymphocytes--DNA (= deoxyribonucleic acid) synthesis and expression of Interleukin-2-receptor; structural modification of DNA, unscheduled DNA synthesis and sister chromatid exchanges. Besides reducing the number of natural killer cells, spaceflight caused on impairment of lymphocyte activity and a slight modification of DNA structure. 4 weeks after flight, control values were reestablished, indicating efficient repair mechanisms.
Tuschl
H
H
Osterreichisches Forschungszentrum Seibersdorf Ges.m.b.H., Osterreich.
Kovac
R
R
Klein
W
W
Ott
E
E
Voronkov
Y I
YI
Kaidakow
M
M
D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007121:Immunocompetence / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D012854:Sister Chromatid Exchange; D013026:Space Flight; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014893:Weightlessness
Genetische und immunologische Untersuchungen nach einem Raumflug.