[Metabolic aspects of synthetic corticoids].
A number of corticoid derivatives have been synthesized principally to develop compounds which increase the ratio of anti-inflammatory effect of corticoid to that not essential for a specific therapeutic applications. During the course of the development, compounds which have a potent mineralcorticoid activity have also been synthesized. This discussion will review components influencing the response to corticoid therapy, with special reference to the structure-activity relationship, including absorption, interconversion between 11-ol and 11-ketone, distribution, metabolic aspects, and elimination. Drug interaction that may contribute to inadequate response to steroid therapy will also be reviewed.
Numazawa
M
M
Tohoku College of Pharmacy.
D000305:Adrenal Cortex Hormones / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D001623:Betamethasone / Q000493:pharmacokinetics; D003345:Corticosterone / Q000493:pharmacokinetics; D004347:Drug Interactions; D006801:Humans; D006854:Hydrocortisone / Q000493:pharmacokinetics; D011239:Prednisolone / Q000493:pharmacokinetics; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D000305:Adrenal Cortex Hormones; D001623:Betamethasone; D011239:Prednisolone; D003345:Corticosterone; D006854:Hydrocortisone