title: A molecular investigation suggests no relationship between obsessive-compulsive disorder and the dopamine D2 receptor.
abstract: Some studies suggest a relationship between obsessive-compulsive disorder (OCD) and Gilles de la Tourette's syndrome. The pathophysiology of the latter may involve the dopamine system. We screened three important exons of the dopamine D2 receptor (DRD2) gene for mutations in a group of OCD patients with or without tics. No structural changes were found, suggesting no relationship between DRD2 and OCD. Moreover, the frequency of the polymorphism in exon 6 was different from that found in schizophrenics.
authors.affiliation: Department of Biomedical and Technological Sciences, University of Milan Medical School, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Novelli
authors.forename: M
authors.initials: M
authors.lastname: Nobile
authors.forename: G
authors.initials: G
authors.lastname: Diaferia
authors.forename: G
authors.initials: G
authors.lastname: Sciuto
authors.forename: M
authors.initials: M
authors.lastname: Catalano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005091:Exons; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009771:Obsessive-Compulsive Disorder / Q000235:genetics / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism*; D013981:Tic Disorders / Q000235:genetics
chemical_list: D017448:Receptors, Dopamine D2; D004247:DNA