title: Intrathecal synthesis of IgG in simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta).
abstract: We examined cerebrospinal fluid (CSF) and serum from 25 simian immunodeficiency (SIV)-infected rhesus macaques for the presence of SIV-specific immunoglobulin G (IgG) and for intrathecal synthesis of IgG. SIV-specific IgG was present in CSF from almost 50% of the macaques. In approximately half of these animals the SIV-specific IgG appeared to be derived from serum by leakage across a disrupted blood-brain barrier, whereas in the remaining animals there was evidence of intrathecal IgG synthesis. There were no significant associations between CSF SIV-specific IgG, intrathecal IgG synthesis and isolation of virus from CSF, clinical status, or neuropathological findings. However, SIV-specific IgG was absent from CSF in all four of the macaques with SIV encephalitis. The presence of SIV-specific IgG in CSF may have a modulating effect on the development of SIV-associated neurological disease.
authors.affiliation: California Regional Primate Research Center, University of California at Davis 95616.
authors.forename: M O
authors.initials: MO
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Sutjipto
authors.forename: A A
authors.initials: AA
authors.lastname: Lackner
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D015153:Blotting, Western; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification; D013116:Spinal Cord / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G