Cytokine gene transfer for the treatment of cancer.
Major progress has been made in the understanding not only of the molecular mechanisms involved in the pathogenesis of cancer, but also of the complex relations between cancer and the immune system. Among the more promising approaches of gene therapy for cancer is the manipulation of the immune system, with the development of an immune antitumoral systemic response. Transfer of some cytokine gene in tumor cells has especially been shown to induce an immune response protecting the animal against subsequent injection of parental tumor cells, and can even, in some cases, treat efficiently animals carrying a preexisting parental tumors. These new experimental data form the basis for the recent elaboration of a rapidly increasing number of clinical protocols using cytokine gene transfer for the treatment of human cancer.
Bruyns
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Department of Medical Genetics, Université Libre de Bruxelles, Brussels, Belgium.
Gérard
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Velu
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D000818:Animals; D003131:Combined Modality Therapy; D016207:Cytokines / Q000235:genetics*; D018014:Gene Transfer Techniques; D006801:Humans; D007167:Immunotherapy; D008214:Lymphocytes / Q000502:physiology; D009369:Neoplasms / Q000628:therapy*; D014407:Tumor Cells, Cultured
D016207:Cytokines