Transfer of elevated anti-S-100 autoimmunity from mother to offspring in rats.
Pregnant Wistar female rats were injected with polyclonal rabbit antibodies (AB) to S-100 brain protein. Control groups received equivalent amount of AB to bovine serum albumin or non-immune rabbit's IgG. An increased level of anti-S100 immunoreactivity was detected by ELISA or its enhanced variant ASPAG (from Amplified Solid Phase Attached Antigen-Antibody Grid formation) in the serum of 1 month old offsprings of group treated with AB to S-100. Obtained data indicate the possibility of inborn epigenetical "imprinting" of specific autoimmune reactions which may be important for the development of certain forms of nervous system diseases.
Poletaev
A B
AB
Chernobyl-TEST Center, Moscow, Russia.
Selifanova
O P
OP
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007112:Immunity, Maternally-Acquired; D011247:Pregnancy; D011817:Rabbits / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D009418:S100 Proteins / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology
D001323:Autoantibodies; D009418:S100 Proteins; D012710:Serum Albumin, Bovine