title: [Suspected inherited granulocytopathy in four Holstein Friesian calves].
abstract: Five Holstein Friesian calves varying in age from 7 to 9 weeks old, were suspected of suffering from an inherited granulocytopathy known as bovine leucocyte adhesion deficiency (BLAD). Four of them were examined clinically and at necropsy. The most significant clinical findings were fever, depression, weakness, emaciation, diarrhoea, pseudomembranous gingivitis, loose teeth, respiratory infection and occult blood in the faeces. Significant clinicopathological findings were marked leucocytosis, mainly due to a neutrophilia, hypoalbuminemia, hypogammaglobulinemia, increased alpha- and beta-globulins, elevated alkaline phosphatase enzyme activity, hypoglycaemia, and decreased blood urea concentrations. The necropsy revealed emaciated carcasses, granulomatous to necrotising gingivitis, pseudomembranous to necrotising enteritis with perforations, bronchopneumonia, splenic atrophy, and hypoplasia of the thymus. Histopathological examination supported the macroscopic findings.
authors.affiliation: Departement Geneeskunde, Fakulteit Veeartsenykunde, Universiteit van Pretoria, Onderstepoort, Republick van Suid-Afrika.
authors.forename: P
authors.initials: P
authors.lastname: Stadler
authors.forename: S R
authors.initials: SR
authors.lastname: Van Amstel
authors.forename: I B
authors.initials: IB
authors.lastname: Van Rensburg
authors.forename: M C
authors.initials: MC
authors.lastname: Williams
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000235:genetics / Q000473:pathology*; D002448:Cell Adhesion; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D007962:Leukocytes / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D009336:Necrosis; D013950:Thymus Gland / Q000473:pathology
vernacular_title: Verdagte oorerflike granulositopatie in vier Holstein frieskalwers.