Isologous and heterologous platelet aggregation induced by tumor cells from three murine mammary gland adenocarcinomas with different metastatic abilities.
The addition of neoplastic cells (NC) isolated from murine mammary gland adenocarcinomas having moderate and high metastatic ability on in vitro heparinized mice platelet rich plasma (PRP) induced platelet aggregation. One non-metastatic line did not induce aggregation. The aggregatory effect was not correlated with the metastatic abilities. None of the three types of tumors did cause aggregation on whole blood or PRP of rats. These adenocarcinomas seem to be suitable models to study in vitro the interactions between platelets and tumor cells having metastatic and non-metastatic potentials.
Pasqualini
M E
ME
Instituto de Biologia Celular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina.
Eynard
A R
AR
D000230:Adenocarcinoma / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis; D010974:Platelet Aggregation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured