Effects of natural human interleukin-6 on thrombopoiesis and tumor progression in tumor-bearing mice.
The growth of inoculated colon 26 adenocarcinoma (colon 26) in mice gradually increased the platelet count owing to murine IL-6 secreted from the tumor, while Lewis lung carcinoma (LLC) decreased the platelet count in the hosts, depending on the tumor growth. Natural human IL-6 injections (hIL-6), 280 micrograms/kg/day, stimulated the platelet production in both types of carcinoma-bearing mice. When the administration of mitomycin C or cisplatin decreased the platelet number as a side reaction with a concomitant of suppressing the growth of colon 26 and LLC, respectively, hIL-6 could also increase the platelet count without the augmentation of tumor growth. However, loss of carcass weight was observed in colon 26-bearing mice treated with hIL-6, suggesting the development of cachexia is associated with hIL-6 administration. Despite the possibility of inducing cachexia in some types of tumors, our results suggest that IL-6 could be a useful means of restoring the decreased platelet number in cancer patients after intensive chemotherapy.
Yoshizawa
K
K
Basic Research Laboratories, Toray Industries Inc., Kanagawa, Japan.
Okamoto
T
T
Moriya
K
K
Izawa
A
A
Satoh
Y
Y
Naruto
M
M
Ida
N
N
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010976:Platelet Count / Q000187:drug effects*; D013997:Time Factors
D015850:Interleukin-6