Defective interfering particles and virus evolution.
Almost all viruses produce replication-defective mutants that have complex effects on the growth and evolution of the virus in culture. These effects can be explained qualitatively by a simple mathematical model. However, the model shows that the quantitative effects of these mutants are intrinsically unpredictable.
Bangham
C R
CR
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Kirkwood
T B
TB
D005075:Biological Evolution; D003673:Defective Viruses / Q000502:physiology*; D014779:Virus Replication