title: Acquired type II protein C deficiency in a long-term hemodialysis patient.
abstract: We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreased protein C activity despite a normal protein C antigen level. None of his relatives had decreased protein C activity, and the levels of the other coagulation factors synthesized by the liver were all normal. Accordingly, the patient was diagnosed as having acquired type II protein C deficiency.
authors.affiliation: Department of Medicine (II), Niigata University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Maruyama
authors.forename: F
authors.initials: F
authors.lastname: Gejyo
authors.forename: M
authors.initials: M
authors.lastname: Hanano
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
mesh_terms: D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020151:Protein C Deficiency; D006435:Renal Dialysis / Q000009:adverse effects*; D013924:Thrombophlebitis / Q000209:etiology