title: [Effect of exogenously administered ATP on heart function and energy status].
abstract: It has been shown that ATP (24.10(-6) M) administered once into the circulating solution improved strength and speed characteristics of aerobically perfused hearts. The increasing demands of the hearts in oxygen and energy substrates were satisfied due to coronary vessels dilatation without harming the energy status of the myocardium. When the functional parameters of the hearts in the test and control groups did not differ, an exogenously administered ATP was included into the energy metabolism and increased considerably ATP and CP tissue levels, the sum of high-energy phosphates and ATP/ADP ratio. Artificial supplementation of tissue energy resources was accompanied by a decrease in energy-dependent end-diastolic pressure and diastolic left ventricular elasticity and by increased extensibility of the heart muscle, which may improve functional parameters.
authors.forename: V S
authors.initials: VS
authors.lastname: Chernikov
authors.forename: T M
authors.initials: TM
authors.lastname: Darbinian
authors.forename: N P
authors.initials: NP
authors.lastname: Bakuleva
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D008297:Male; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000255:Adenosine Triphosphate
vernacular_title: Vliianie ékzogenno vvedennoĭ ATF na funktsiiu i énergeticheskoe sostoianie serdtsa.