title: Osseous substance formation induced in porous calcium phosphate ceramics in soft tissues.
abstract: Porous calcium phosphate ceramics prepared according to the methods of laboratories in Leiden were implanted subcutaneously in rats for 3, 6 and 12 w. No bone formation could be observed. Porous calcium phosphate ceramics prepared according to the methods of laboratories in Sichuan were implanted subcutaneously/intramuscularly in dogs for 1, 3, 5 and 7 months. In particular, ceramics containing alpha-tricalcium phosphate evoked bone formation in the pores of the ceramics. The amount of bone was similar at the different time periods.
authors.affiliation: Department of Biomaterials, School of Medicine, Leiden, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.forename: K
authors.initials: K
authors.lastname: de Groot
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000473:pathology; D002130:Calcium Phosphates / Q000494:pharmacology*; D002516:Ceramics; D004285:Dogs; D019736:Prostheses and Implants; D051381:Rats
chemical_list: D002130:Calcium Phosphates