Intra-abdominal adhesion formation is initiated by phospholipase A2.
The etiology of intra-abdominal adhesions is explained by hydrolysis of the peritoneal phospholipid layer caused by phospholipase A2 activity. This view could unify the pre-existing hypotheses that intra-abdominal adhesions are due to ischemia or increased plasminogen activator activity. New therapeutic approaches are suggested.
Snoj
M
M
Department of Surgery, Institute of Oncology, Ljubljana, Slovenia.
D000005:Abdomen; D000818:Animals; D006801:Humans; D006868:Hydrolysis; D008954:Models, Biological; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D011183:Postoperative Complications / Q000209:etiology; D051381:Rats; D000267:Tissue Adhesions / Q000209:etiology* / Q000517:prevention & control
D010743:Phospholipids; D010741:Phospholipases A; D054467:Phospholipases A2