title: Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.
abstract: Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.
authors.affiliation: Zentrum für Molekulare Neurobiologie Hamburg, Institut für Neurale Signalverarbeitung, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Rettig
authors.forename: S H
authors.initials: SH
authors.lastname: Heinemann
authors.forename: F
authors.initials: F
authors.lastname: Wunder
authors.forename: C
authors.initials: C
authors.lastname: Lorra
authors.forename: D N
authors.initials: DN
authors.lastname: Parcej
authors.forename: J O
authors.initials: JO
authors.lastname: Dolly
authors.forename: O
authors.initials: O
authors.lastname: Pongs
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003001:Cloning, Molecular; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D051038:Large-Conductance Calcium-Activated Potassium Channel beta Subunits; D008564:Membrane Potentials / Q000502:physiology; D008969:Molecular Sequence Data; D009865:Oocytes / Q000502:physiology; D010446:Peptide Fragments; D015221:Potassium Channels / Q000737:chemistry* / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017386:Sequence Homology, Amino Acid; D014982:Xenopus laevis
chemical_list: C494839:Kcnab1 protein, rat; C494840:Kcnab3 protein, rat; D051038:Large-Conductance Calcium-Activated Potassium Channel beta Subunits; D010446:Peptide Fragments; D015221:Potassium Channels; D012333:RNA, Messenger