title: [Cellular immunity in patients with newly detected insulin-dependent diabetes mellitus].
abstract: Twenty-five diabetics with insulin-dependent condition were examined at the debut of the disease before insulin therapy, as were 10 healthy donors. Under study were relative and absolute counts of T lymphocytes, NK cells, B lymphocytes, DR-T lymphocytes, Th, Ts, and Th/Ts index. Patients' and donors' sera were tested for autoantibodies to P64-69kD antigenic complex. Characteristic features of cellular immunity of patients with newly-detected diabetes were disclosed. Counts of B lymphocytes and Dr-T lymphocytes were increased in all patients. A relationship was revealed between immunoregulatory Th/Ts index and clinical features of insulin-dependent diabetes. Autoantibodies to p64-68 kD andigenic complex were detected in 63-88% of patients with newly detected insulin-dependent diabetes.
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
authors.forename: L A
authors.initials: LA
authors.lastname: Chugunova
authors.forename: O M
authors.initials: OM
authors.lastname: Smirnova
authors.forename: S V
authors.initials: SV
authors.lastname: Brykova
authors.forename: T S
authors.initials: TS
authors.lastname: Shchegol'kova
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D008297:Male
chemical_list: D001323:Autoantibodies
vernacular_title: Osobennosti kletochnogo immuniteta u bol'nykh s vpervye vyiavlennym insulinzavisimym sakharnym diabetom.