Adenosine coronary vasodilation during hypoxia depends on adrenergic receptor activation.
The adenosine hypothesis of coronary control was investigated during steady-state hypoxia by making measurements of coronary venous and epicardial well adenosine concentrations in adrenergically intact dogs and animals with alpha - and beta-receptor blockade. The unexpected result was that a role for adenosine coronary vasodilation during hypoxia could only be found when adrenergic receptors were intact, but not during adrenergic blockade.
Feigl
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Department of Physiology and Biophysics, University of Washington, Seattle 98195.
D000241:Adenosine / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
D011941:Receptors, Adrenergic; D000241:Adenosine