title: Defective interfering particles and virus evolution.
abstract: Almost all viruses produce replication-defective mutants that have complex effects on the growth and evolution of the virus in culture. These effects can be explained qualitatively by a simple mathematical model. However, the model shows that the quantitative effects of these mutants are intrinsically unpredictable.
authors.affiliation: Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
authors.forename: C R
authors.initials: CR
authors.lastname: Bangham
authors.forename: T B
authors.initials: TB
authors.lastname: Kirkwood
mesh_terms: D005075:Biological Evolution; D003673:Defective Viruses / Q000502:physiology*; D014779:Virus Replication