Different incidence of venous thrombosis in patients with inherited deficiencies of antithrombin III, protein C and protein S.
A cohort study was undertaken to compare the incidence of thrombosis in patients with inherited deficiency of Antithrombin III (n = 9), Protein C (n = 36) and Protein S (n = 36). The patients were stratified for schedule of antithrombotic prophylaxis and followed for a total period of 160 patient-years. Seven venous thrombosis were observed for a total incidence of 4.3% pts.-ys. The incidence of thrombosis was not significantly different in patients of different age, sex and schedule of prophylaxis, although there was a trend to a lower incidence in young individuals and in those receiving long-term oral anticoagulation. Patients with AT III deficiency had an higher incidence of thrombosis than patients with Protein C or Protein S deficiency (12 vs. 2.8 vs. 3.3% pts.-ys, p < 0.05), despite the fact that they were, on average, younger and more prophylaxed. This study suggests that congenital Antithrombin III deficiency constitutes a greater risk of thrombosis than congenital deficiencies of Protein C and Protein S.
Finazzi
G
G
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy.
Barbui
T
T
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D000990:Antithrombin III / Q000235:genetics; D020152:Antithrombin III Deficiency; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency; D017293:Protein S / Q000235:genetics; D018455:Protein S Deficiency; D013924:Thrombophlebitis / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control
D000925:Anticoagulants; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III