title: Diffuse-variant tenosynovial giant cell tumor: a rare and aggressive lesion.
abstract: The diffuse-variant tenosynovial giant cell tumor is rare. Although it shares histologic features with the exclusively intra-articular pigmented villonodular synovitis and local tenosynovial giant cell tumor, its behavior differs dramatically, being locally very aggressive. We report a case of a diffuse-variant aggressive tenosynovial giant cell tumor that, although diploid by flow cytometry, demonstrated trisomy 7 and 5 as well as clonal rearrangements involving chromosomes 1, 3, and 15. These cytogenetic abnormalities may be markers for aggressive behavior and useful for directing treatment.
authors.affiliation: Department of Histopathology, Foothills Hospital, Calgary, Alberta, Canada.
authors.forename: C G
authors.initials: CG
authors.lastname: Rowlands
authors.forename: B
authors.initials: B
authors.lastname: Roland
authors.forename: W S
authors.initials: WS
authors.lastname: Hwang
authors.forename: R J
authors.initials: RJ
authors.lastname: Sevick
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005434:Flow Cytometry; D005870:Giant Cell Tumors / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D007717:Knee; D008297:Male; D008854:Microscopy, Electron; D009361:Neoplasm Invasiveness; D013583:Synovial Membrane / Q000473:pathology; D013710:Tendons / Q000473:pathology; D013717:Tenosynovitis / Q000473:pathology