title: [Hydantoin fetal syndrome].
abstract: We report a case of distal finger hypoplasia associated with foetal hydantoin syndrome (FHS). The occurrence of this syndrome is thought to be due to abnormalities of collagen, cytochrome P 450 and arachidonic acid metabolism. The risk of developing FHS could be evaluated by counting the glucocorticoid receptors of lymphocytes or by measuring epoxide hydrolase activity through amniocentesis. FHS can be prevented by taking folates during pregnancy.
authors.affiliation: Service de Dermatologie, CHRU Limoges.
authors.forename: P M
authors.initials: PM
authors.lastname: Dang
authors.forename: B
authors.initials: B
authors.lastname: Dufetelle
authors.forename: J M
authors.initials: JM
authors.lastname: Bonnetblanc
mesh_terms: D000328:Adult; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006228:Hand Deformities, Congenital / Q000139:chemically induced*; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects* / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D009264:Nails, Malformed; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy
chemical_list: D006827:Hydantoins
vernacular_title: Syndrome foetal à l'hydantoïne.