title: Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction.
abstract: BACKGROUND
  Animal studies have demonstrated a burst of oxygen free radical generation after reperfusion of ischemic myocardium that could be blocked by administration of the free radical scavenger recombinant human superoxide dismutase (h-SOD). A multicenter, randomized, placebo-controlled clinical trial was designed to test the hypothesis that free radical-mediated reperfusion injury could be reduced by intravenous administration of h-SOD begun before percutaneous transluminal coronary angioplasty (PTCA) in patients with acute transmural myocardial infarction.
  
  
  RESULTS
  One hundred twenty patients were randomized to receive placebo (n = 59) or h-SOD (n = 61) given as a 10-mg/kg intravenous bolus followed by a 60-minute infusion of 0.2 mg.kg-1.min-1. Left ventricular function was analyzed via paired contrast left ventriculograms performed before PTCA and after 6 to 10 days and paired radionuclide ventriculograms performed within 24 hours of PTCA and after 4 to 6 weeks. Both h-SOD- and placebo-treated patients showed improvement in global and regional left ventricular function after successful reperfusion. Compared with the placebo group, no additional improvement was observed in the patients treated with h-SOD.
  
  
  CONCLUSIONS
  The results of this clinical trial failed to demonstrate a beneficial effect of h-SOD on global or regional left ventricular function in patients who underwent successful PTCA for treatment of acute myocardial infarction.
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore, Md.
authors.forename: J T
authors.initials: JT
authors.lastname: Flaherty
authors.forename: B
authors.initials: B
authors.lastname: Pitt
authors.forename: J W
authors.initials: JW
authors.lastname: Gruber
authors.forename: R R
authors.initials: RR
authors.lastname: Heuser
authors.forename: D A
authors.initials: DA
authors.lastname: Rothbaum
authors.forename: L R
authors.initials: LR
authors.lastname: Burwell
authors.forename: B S
authors.initials: BS
authors.lastname: George
authors.forename: D J
authors.initials: DJ
authors.lastname: Kereiakes
authors.forename: D
authors.initials: D
authors.lastname: Deitchman
authors.forename: N
authors.initials: N
authors.lastname: Gustafson
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D015716:Electrocardiography, Ambulatory; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D011994:Recombinant Proteins; D013482:Superoxide Dismutase