title: Infective endocarditis in infants and children during the past ten years.
abstract: BACKGROUND
  Infective endocarditis occurs infrequently in the general pediatric population, but is often associated in patients with underlying heart disease. Even today it remains a serious threat leading to relevant mortality in all pediatric groups, in spite of better antibiotic treatment and prophylactic measures for endangered persons. This retrospective analysis reports experience here with infective endocarditis in children.
  
  
  METHODS
  The clinical and laboratory findings in 28 children with 30 episodes of infective endocarditis, from July 1984 to June 1993, were reviewed retrospectively.
  
  
  RESULTS
  Twenty-one children (75 percent) had congenital heart disease, three (11 percent) had rheumatic heart disease and four (14 percent) had no underlying cardiac abnormality prior to presentation. Twenty-six (87 percent) of the 30 episodes had positive blood cultures. The most common organism isolated was streptococcus viridans (14 percent), followed by staphylococcus aureus (7 percent). Echocardiography identified vegetation in 21 of 28 (75 percent) patients. Twenty children were successfully treated medically. Four developed complications requiring surgery, of whom two died. A total of six children (21 percent) died of the disease or its complications. There were a high case fatality rate for children below the age of two years (75 percent), and children without an underlying cardiac abnormality (50 percent).
  
  
  CONCLUSIONS
  It was concluded that patient survival is dependent on several factors which include early diagnosis, appropriate antimicrobial therapy and aggressive surgical intervention.
authors.affiliation: Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, R.O.C.
authors.forename: S C
authors.initials: SC
authors.lastname: Chen
authors.forename: K S
authors.initials: KS
authors.lastname: Hsieh
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Chi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004697:Endocarditis, Bacterial / Q000209:etiology* / Q000628:therapy; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012214:Rheumatic Heart Disease / Q000150:complications; D013203:Staphylococcal Infections; D013290:Streptococcal Infections