Tissue tropism and species specificity of poliovirus infection.
Paralytic poliomyelitis is caused by the destruction of neurons in the central nervous system during the lytic replication of poliovirus. The human gene for the poliovirus receptor has been cloned recently, and transgenic mice generated that are susceptible to this virus. This has allowed the critical amino acids that determine the specificity of poliovirus to be identified.
Nomoto
A
A
Dept of Microbiology, University of Tokyo, Japan.
Koike
S
S
Aoki
J
J
D000595:Amino Acid Sequence; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011051:Poliomyelitis / Q000209:etiology / Q000235:genetics / Q000382:microbiology*; D017955:Poliovirus / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011991:Receptors, Virus / Q000737:chemistry / Q000235:genetics; D013045:Species Specificity
D008565:Membrane Proteins; D012333:RNA, Messenger; D011991:Receptors, Virus; C066100:poliovirus receptor