title: Cerebral metabolic changes in delayed carbon monoxide sequelae studied by proton MR spectroscopy.
abstract: The pathogenesis of delayed sequelae of carbon monoxide (CO) exposure is still unknown. We repeatedly examined a 55-year-old woman with the interval form of CO poisoning, using proton magnetic resonance spectroscopy (MRS). When the clinical picture was severe, MRS revealed markedly lowered N-acetyl-aspartate (NAA)/creatine and phosphocreatine (Cr) ratio and slightly increased choline containing compounds (Cho)/Cr ratio. Subsequently, NAA and Cho/Cr ratio tended to return to normal, reflecting clinical improvement. Proton MRS shows the previously unrecognised neuronal activity in CO poisoning and precisely reflects the severity of symptoms. We stress the superiority of proton MRS over the conventional radiological examinations in CO poisoning.
authors.affiliation: Kashiwaba Neurosurgical Hospital, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kamada
authors.forename: K
authors.initials: K
authors.lastname: Houkin
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Koiwa
authors.forename: T
authors.initials: T
authors.lastname: Kashiwaba
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Abe
mesh_terms: D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002249:Carbon Monoxide Poisoning / Q000378:metabolism*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D011522:Protons
chemical_list: D011522:Protons