title: Histologic predictive factors. Therapeutic impact in vulvar cancer.
abstract: In 59 cases of vulvar invasive squamous cell carcinoma treated with radical vulvectomy and inguino-femoral lymphadenectomy, seven histologic parameters were evaluated to establish their predictive value in the development of lymph node metastasis. The most significant was vascular involvement, observed in 86% of cases with lymph node metastases (P < .000004). Depth of stromal invasion and tumor thickness were highly significant, with P < .008 and < .007, respectively, with 0% lymph node metastases in tumors thinner than 1 mm and 62% and 60%, respectively, in those thicker than 5 mm. The growth pattern correlated with lymph node metastases but was not statistically significant. The histologic grade correlated with positive lymph nodes, with P < .04. The amount of keratin (P < .91) was not related. These histologic factors allow the identification of patients with a lower risk of developing lymph node metastases and in whom conservative surgery on the vulva and inguino-femoral lymph nodes is feasible.
authors.affiliation: Department of Pathology, University Hospital, Buenos Aires, Argentina.
authors.forename: N
authors.initials: N
authors.lastname: Gómez Rueda
authors.forename: S
authors.initials: S
authors.lastname: Vighi
authors.forename: A
authors.initials: A
authors.lastname: Garcia
authors.forename: L
authors.initials: L
authors.lastname: Cardinal
authors.forename: M G
authors.initials: MG
authors.lastname: Belardi
authors.forename: G
authors.initials: G
authors.lastname: di Paola
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012307:Risk Factors; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery