title: Teaching fibreoptic intubation. Effect of alfentanil on the haemodynamic response.
abstract: A technique for teaching fibreoptic orotracheal intubation in patients under general anaesthesia is described and evaluated. A standard general anaesthetic was administered to 60 patients presenting for elective gynaecological surgery. Patients were randomly assigned to receive either alfentanil 10 micrograms.kg-1 or a placebo, and to be intubated either by a consultant experienced in the use of the fibreoptic bronchoscope or by an inexperienced trainee under instruction. Heart rate, arterial pressure and oxygen saturation were monitored continuously. The time to achieve tracheal intubation in the trainee group was significantly prolonged (p < 0.001), but no patient developed arterial desaturation. The hypertensive response to fibreoptic intubation was suppressed in those patients who received alfentanil (p < 0.001). The increase in heart rate was not suppressed, but was attenuated when these patients were compared with those who had received the placebo (p < 0.001). Alfentanil 10 micrograms.kg-1 minimises the haemodynamic response when teaching fibreoptic orotracheal intubation under general anaesthesia.
authors.affiliation: Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff.
authors.forename: M
authors.initials: M
authors.lastname: Hartley
authors.forename: S
authors.initials: S
authors.lastname: Morris
authors.forename: R S
authors.initials: RS
authors.lastname: Vaughan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015760:Alfentanil / Q000494:pharmacology*; D000768:Anesthesia, General; D000776:Anesthesiology / Q000193:education*; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D004503:Education, Medical, Graduate; D005260:Female; D005336:Fiber Optic Technology / Q000193:education; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013997:Time Factors
chemical_list: D015760:Alfentanil; D010100:Oxygen