The role of catecholamines in the distribution of steroid hormones in the striated and cardiac muscle.
Loss of muscular strength is a well-known component of the clinical picture many endocrine diseases and is often their predominant aspect. It has recently been proved that the cytoplasmatic receptors for steroid hormones (SH) are artefacts of the fixation techniques and that they are attached to the internal surface of the cell membrane. Our experiment was made on male and female. Wistar rats which were tested for the level of radioactively labelled steroid hormones (3H and HD3H hydrocortisone; 3H testosterone, TS3H; 3H estrone, FS3H) in various types of skeletal muscles (from rapid to slow) and cardiac muscle before and after adrenalin administration. Before adrenalin administration one noticed: (a) a significantly higher level of HD3H (p < 0.05) in the female skeletal muscle; (b) in the femoral biceps and psoas, a significantly higher distribution of TS3H in males (p < 0.01), whereas in the diaphragm and the heart, there were no significant differences between sexes; (c) there are significant differences between sexes as regards the ES3H level in any of the studied muscles. After adrenalin administration there was a significant decrease in the level of labelled SH uptake in all experimental schemes. It is possible that adrenalin block the HS diffusion through the plasma membrane or even their binding to specific receptors.
Burtea
C
C
Victor Babeş Institute, Bucharest, Romania.
David
A
A
Butnaru
F
F
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D004970:Estrone / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011987:Receptors, Steroid / Q000187:drug effects / Q000378:metabolism; D012727:Sex Characteristics; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium
D011987:Receptors, Steroid; D014316:Tritium; D004970:Estrone; D013739:Testosterone; D006854:Hydrocortisone; D004837:Epinephrine