Cellular distribution of calbindin D28K mRNAs in the adult mouse brain.
We have determined the cellular distribution of calbindin D28K mRNAs throughout the mouse brain by in situ hybridization. While these studies identified neuronal populations similar to those previously identified in rat brain by immunohistochemistry, some discrepancies exist. These may derive from species differences or from the immunological cross-reactivity of calbindin D28K antiserum with other proteins. We note an intriguing association between the distribution of neurons containing calbindin D28K mRNA and those reported by others to contain the inositol 1,4,5-triphosphate (InsP3) receptor.
Frantz
G D
GD
Department of Biology, University of California, Los Angeles 90024-1606.
Tobin
A J
AJ
D000818:Animals; D016375:Antisense Elements (Genetics); D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000166:cytology*; D001923:Brain Chemistry / Q000502:physiology*; D064092:Calbindin 1; D064026:Calbindins; D015220:Calcium Channels / Q000378:metabolism; D003429:Cross Reactions; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000276:immunology / Q000378:metabolism*
D016375:Antisense Elements (Genetics); C576499:Calb1 protein, mouse; C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D064030:S100 Calcium Binding Protein G; D012260:Ribonucleases