Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.
Marsh
D G
DG
Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224.
Neely
J D
JD
Breazeale
D R
DR
Ghosh
B
B
Freidhoff
L R
LR
Ehrlich-Kautzky
E
E
Schou
C
C
Krishnaswamy
G
G
Beaty
T H
TH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D007073:Immunoglobulin E / Q000097:blood*; D015847:Interleukin-4 / Q000235:genetics*; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
D000485:Allergens; D005819:Genetic Markers; D015847:Interleukin-4; D007073:Immunoglobulin E