Laryngeal transplantation: a program for investigating new parameters.
Laryngeal transplantation was actively investigated in the late 1960s and early 1970s using a dog model. An expanded knowledge base in immunobiology, pharmacology, and deglutition makes reassessment timely after an approximately 20-year hiatus. The basic parameters to be evaluated include varied methods of preservation, optimal immunosuppressive drug regimens, and the role of radiation therapy. Our current research protocol addressing the latter considerations is outlined, including a brief introduction of a new animal model developed specifically for this purpose. We will ultimately attempt to answer the question: Is laryngeal transplantation feasible?
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Joint Center for Otolaryngology, Brigham & Women's Hospital, Boston, Massachusetts.
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D000714:Anastomosis, Surgical; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D016572:Cyclosporine / Q000494:pharmacology; D007165:Immunosuppression Therapy; D007830:Larynx / Q000637:transplantation*; D051381:Rats; D014180:Transplantation / Q000639:trends*
D000911:Antibodies, Monoclonal; D016572:Cyclosporine