title: [Genetic and immunologic studies after space flight].
abstract: The effect of spaceflight on lymphocytes of the peripheral blood was investigated in the Austrian cosmonaut flying the Austro-Soviet mission Austromir. Blood was sampled before and after flight, and the following parameters studied: quantities of lymphocytic subsets (T cells, helper cells, suppressor cells, B cells and natural killer cells); mitogenic stimulation of lymphocytes--DNA (= deoxyribonucleic acid) synthesis and expression of Interleukin-2-receptor; structural modification of DNA, unscheduled DNA synthesis and sister chromatid exchanges. Besides reducing the number of natural killer cells, spaceflight caused on impairment of lymphocyte activity and a slight modification of DNA structure. 4 weeks after flight, control values were reestablished, indicating efficient repair mechanisms.
authors.affiliation: Osterreichisches Forschungszentrum Seibersdorf Ges.m.b.H., Osterreich.
authors.forename: H
authors.initials: H
authors.lastname: Tuschl
authors.forename: R
authors.initials: R
authors.lastname: Kovac
authors.forename: W
authors.initials: W
authors.lastname: Klein
authors.forename: E
authors.initials: E
authors.lastname: Ott
authors.forename: Y I
authors.initials: YI
authors.lastname: Voronkov
authors.forename: M
authors.initials: M
authors.lastname: Kaidakow
mesh_terms: D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007121:Immunocompetence / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D012854:Sister Chromatid Exchange; D013026:Space Flight; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014893:Weightlessness
vernacular_title: Genetische und immunologische Untersuchungen nach einem Raumflug.