title: An inflammatory eruption associated with recombinant human IL-6.
abstract: Interleukin 6 (IL-6) is an endogenous cytokine with multiple biological functions, including amplification of the inflammatory response. Recombinant human IL-6, administered as part of a chemotherapeutic regimen, has recently been shown to cause regression of certain types of malignant tumours. We report a patient who developed a cutaneous eruption consisting of coalescent, erythematous, scaling macules and papules after administration of recombinant human IL-6, given as part of her chemotherapy for ductal carcinoma of the breast.
authors.affiliation: Department of Dermatology, University Hospitals of Cleveland, Ohio 44106.
authors.forename: T E
authors.initials: TE
authors.lastname: Fleming
authors.forename: W S
authors.initials: WS
authors.lastname: Mirando
authors.forename: L F
authors.initials: LF
authors.lastname: Soohoo
authors.forename: B W
authors.initials: BW
authors.lastname: Cooper
authors.forename: M T
authors.initials: MT
authors.lastname: Zaim
authors.forename: H M
authors.initials: HM
authors.lastname: Lazarus
authors.forename: C A
authors.initials: CA
authors.lastname: Elmets
mesh_terms: D000328:Adult; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000009:adverse effects; D012867:Skin / Q000473:pathology
chemical_list: D015850:Interleukin-6; D011994:Recombinant Proteins