title: Magnetic resonance imaging of the submandibular-sublingual complex.
abstract: The submandibular-sublingual complex (SSC) was studied in vivo by magnetic resonance imaging (MRI) at 4.7 and 7.05 Tesla in rat and mouse. A correlation was found between histology and MRI signal. The mainly mucous sublingual gland emitted a more intense signal than the mainly serous submandibular gland. Ventral to the glands, cutis, subcutaneous adipose tissue and two planes of muscular tissue separated by connective laminae were visible in vivo. Autopsy and histology confirmed the in vivo description provided by MRI. The reactivity of the salivary system after pharmacological stimulation was studied in mice at 7.05 Tesla. Stimulation of salivary secretion by pilocarpine nitrate injected in the subcutaneous space ventrally to the SSC resulted in an augmentation of the salivary liquid visible in the oral cavity by MRI. The diffusion of pilocarpine nitrate in the connective tissue located ventrally the SSC and in the glandular parenchyma was also followed in vivo. These results show that MRI is a potentially useful tool for studying the salivary glands in vivo.
authors.affiliation: Institute of Human Anatomy and Histology, University of Verona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sbarbati
authors.forename: A
authors.initials: A
authors.lastname: Baldassarri
authors.forename: F
authors.initials: F
authors.lastname: Leclercq
authors.forename: F
authors.initials: F
authors.lastname: Merigo
authors.forename: K
authors.initials: K
authors.lastname: Antonakis
authors.forename: A
authors.initials: A
authors.lastname: Boicelli
mesh_terms: D000818:Animals; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D051381:Rats; D013361:Sublingual Gland / Q000033:anatomy & histology*; D013363:Submandibular Gland / Q000033:anatomy & histology*