[Allergic vasculitis caused by Vigabatrin].
A patient with focal epilepsy that was resistant to medical treatment received add-on therapy with vigabatrin. Six months after commencement of vigabatrin therapy, allergic vasculitis caused by vigabatrin was diagnosed. The patient displayed unilateral anterior ischaemic optic neuropathy with impairment of vision and concentric loss of visual field. The diagnosis was based on the lymphocyte transformation test and the clinical course. The allergic vasculitis was healed by cortisone therapy.
Dieterle
L
L
Erwachsenenklinik am Epilepsiezentrum Kork, Medizinischen Universitätsklinik Tübingen.
Becker
E W
EW
Berg
P A
PA
Berkenfeld
R
R
Reinshagen
G
G
D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004342:Drug Hypersensitivity / Q000209:etiology*; D004828:Epilepsies, Partial / Q000188:drug therapy*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005074:Evoked Potentials, Visual / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D008134:Long-Term Care; D008297:Male; D009900:Optic Nerve / Q000098:blood supply*; D009902:Optic Neuritis / Q000139:chemically induced*; D011930:Reaction Time / Q000187:drug effects; D020888:Vigabatrin
D000614:Aminocaproates; D000927:Anticonvulsants; D020888:Vigabatrin
Allergische Vaskulitis durch Vigabatrin.