[The concentration of ascorbic acid, glucose and cortisol in the blood plasma of sheep and the excretion of ascorbic acid in the urine after i.v. administration of the compound].
In lambs, adult female sheep and wethers the influence of the intravenous injection of ascorbic acid (AA) in a dose of 10, 20 or 30 mg/kg body weight (b.w.) on the concentration of AA in the plasma up to 420 minutes thereafter was analysed. Further the concentration of glucose respectively of cortisol in the plasma was determined in some experiments. The results can be used as a basis for investigations in sheep with infectious and parasitic diseases for the determination of the degree of the saturation of the body with AA. For therapeutic purposes the repeated application of a dose of 20 mg AA/kg b.w. is recommended. In wethers a dose dependent excretion of AA in the urine after an i.v. injection of a dose of 10, 20 or 30 mg/kg b.w. was observed. The injection of ACTH, cortisol, adrenaline and noradrenaline had no substantial influence on the concentration of AA in the plasma. In the course of 24 hours there was no alteration in the concentration of AA in the plasma.
Kolb
E
E
Veterinär-Physiologisch-Chemisches Institut, Universität Leipzig.
Kouider
S
S
Kuba
M
M
Leo
M
M
Wahren
M
M
Völker
L
L
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood* / Q000652:urine; D001786:Blood Glucose / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D012756:Sheep / Q000097:blood* / Q000652:urine; D013997:Time Factors
D001786:Blood Glucose; D001205:Ascorbic Acid; D006854:Hydrocortisone
Die Konzentration an Ascorbinsäure, an Glucose und an Cortisol im Blutplasma von Schafen sowie die Ausscheidung von Ascorbinsäure im Harn nach i.v. Verabreichung der Verbindung.