[Usefulness of determining beta-2-microglobulin in serum and urine in patients with metabolically active kidney calculi and healthy individuals].
The study aimed at evaluating the proximal tubule function in patients with active metabolic urolithiasis with the assay of beta 2-microglobulin in the urine. The studies involved 30 patients with urolithiasis associated with chronic pyelonephritis and 31 patients with urolithiasis without pyelonephritis. Fifty healthy individuals served as a control group. Serum and urine beta 2-microglobulin concentrations were assayed with radioimmunological technique in all persons. Clearance of this microglobulin and tubular reabsorption were calculated. It was found that beta 2-microglobulin excretion with the urine is significantly higher in patients with metabolically active urolithiasis accompanied by the chronic pyelonephritis. beta 2-microglobulin clearance was significantly higher and tubular reabsorption significantly lower than those in patients without pyelonephritis and in control group. These finding suggest a dysfunction of the proximal tubule in patients with urolithiasis produced by the chronic inflammatory process in the urinary system. Negative correlation between blood serum beta 2-microglobulin levels and creatinine clearance was shown. Therefore, serum beta 2-microglobulin concentrations may be of value in evaluation of the glomerular filtration rate.
Pupek-Musialik
D
D
Kliniki Nadciśnienia Tetniczego, Instytutu Kardiologii AM im. K. Marcinkowskiego, Poznaniu.
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000097:blood* / Q000209:etiology / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000150:complications; D011863:Radioimmunoassay; D012016:Reference Values; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001613:beta 2-Microglobulin
Przydatność oznaczania beta-2-mikroglobuliny w surowicy i w moczu u chorych z kamica nerkowa aktywna metabolicznie i u osób zdrowych.