Sequential positron emission tomographic evaluations of brain metabolism in acute herpes encephalitis.
This first known positron emission tomography report on metabolic changes in acute herpes simplex virus (HSV-1) encephalitis demonstrates focal hypermetabolism in areas of cerebral cortex adjacent to actively inflamed hippocampus acutely infected with HSV-1. When neuropsychiatric symptoms recurred in a previously healthy 61-year-old patient 1 month after recovering from acute HSV-1 encephalitis, repeat positron emission tomography with fluorodeoxyglucose was helpful in ruling out recurrent active infection by showing marked hypometabolism throughout the previously infected temporal lobe.
Meyer
M A
MA
University of Tennessee Medical Center, Biomedical Imaging Center, Knoxville, TN 37920.
Hubner
K F
KF
Raja
S
S
Hunter
K
K
Paulsen
W A
WA
D000208:Acute Disease; D001921:Brain / Q000378:metabolism*; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006561:Herpes Simplex / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed