Effects of an anti-interleukin-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia.
Because IL-6 has been involved in the pathogenesis of acute monoblastic leukemia, we investigated the in vitro anti-proliferative effect and the in vivo anti-tumoral effect of an anti-IL-6 murine monoclonal antibody (mAb) in a patient with M5B type acute leukemia. In the current study, we clearly show the IL-6 dependence of monoblastic cell viability and proliferation in vitro in short-term cultures of malignant cells and the clinical activity of the anti-IL-6 murine mAb. The complete neutralization of IL-6 in vivo was associated with a transient but complete disappearance of malignant monoblastic cells in the peripheral blood, with improvement or even normalization of several other biological parameters of disease activity. No immunization against the anti-IL-6 murine mAb was observed.
Bataille
R
R
Laboratoire d'Hématologie et Laboratoire d'Oncogénèse Immunohématologique, Institut de Biologie des Hôpitaux de Nantes, France.
Zhang
X G
XG
Wijdenes
J
J
Schved
J F
JF
Klein
B
B
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002455:Cell Division; D002470:Cell Survival; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology*; D007948:Leukemia, Monocytic, Acute / Q000628:therapy*; D008297:Male; D051379:Mice; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D015850:Interleukin-6