Effect of chronic ANG I-converting enzyme inhibition on aging processes. I. Kidney structure and function.
The effect of angiotensin I-converting enzyme inhibition (ACEI) on the age-related changes in the kidney structure and function was investigated in rodents. Normotensive male Wistar (WAG)/Rij rats were treated with perindopril from the age of 6 mo to the day of killing at 12, 24, or 30 mo. Mean blood pressure, constant from 6 to 30 mo, was reduced by 19 mmHg in treated animals. With age, the major functional modifications were a decrease in glomerular filtration rate and in renal blood flow, a rise in intrarenal vascular resistance (IVR), a reduced tubular reabsorption of salts, and a progressive increase in proteinuria. ACEI significantly reduced IVR and proteinuria. From a structural point of view, the glomeruli showed 1) an increase in size, 2) a decrease in capillary surface, 3) a diffuse thickening of the glomerular basement membrane, 4) an expansion of the mesangial matrix, and 5) an accumulation of albumin droplets in podocytes inducing 6) a dispersed focal and segmental glomerulosclerosis which, at 30 mo, affected < 2% of glomeruli. Of these six age-related structural changes, ACEI delayed the appearance of the three latter changes.
Heudes
D
D
Institut National de la Santé et de la Recherche Médicale U 28, Broussais Hospital, Paris, France.
Michel
O
O
Chevalier
J
J
Scalbert
E
E
Ezan
E
E
Bariety
J
J
Zimmerman
A
A
Corman
B
B
D000375:Aging / Q000502:physiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D004435:Eating; D005919:Glomerular Filtration Rate; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000033:anatomy & histology* / Q000502:physiology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors