[Interleukin 3 (IL-3)].
Interleukin 3 (IL-3) was initially described in the supernates of cultures of viral-infected murine spleen cells, as a cytokine produced by T lymphocytes can promote differentiation of immature T lymphocytes. Later, it was found that IL-3 exhibited a striking effect on hematopoiesis. The recombinant molecule of murine and human IL-3 can promote the sustained proliferation of clones of mast cells and basophils. It also acts as a colony stimulating factor (CSF) for bone marrow cells. Although other CSFs generally stimulate specific lineages of myeloid or erythroid cells, IL-3 stimulates bone marrow to induce proliferation of a variety of clonal cell populations, including colonies of granulocytes, macrophages, megakaryocytes, eosinophils, basophils, mast cells, normoblasts and erythroblasts. Thus, IL-3 is responsible for promoting proliferation of earlier lineage pluripotent stem cells, of hematopoietic cells and lymphoid cells. Recently, it is also suggested, as to its effects on lymphocytes, that IL-3 may possibly be a factor responsible for T lymphocytes to be differentiating extra-thymically.
Kusumi
A
A
Dept. of Microbiology, Tohoku University School of Dentistry.
Kumagai
K
K
D000818:Animals; D001491:Basophils / Q000502:physiology; D001854:Bone Marrow Cells; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000502:physiology; D006410:Hematopoiesis; D006801:Humans; D007377:Interleukin-3 / Q000096:biosynthesis / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology; D051379:Mice; D016185:Receptors, Interleukin-3 / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
D003115:Colony-Stimulating Factors; D007377:Interleukin-3; D016185:Receptors, Interleukin-3