Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).
We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor. Bronchoalveolar lavage (BAL) revealed lymphocyte alveolitis with a low CD4/CD8 ratio (0.36), consistent with an immunoallergic phenomenon, rather than the most often evoked toxic hypothesis.
Lena
H
H
Department of Pneumology, Hôpital Pontchaillou-Centre Hospitalier Universitaire de Rennes, France.
Desrues
B
B
Le Coz
A
A
Quinquenel
M L
ML
Delaval
P
P
D000208:Acute Disease; D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy; D002330:Carmustine / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography
D002330:Carmustine