Antimicrobial drug suspensions: a blinded comparison of taste of twelve common pediatric drugs including cefixime, cefpodoxime, cefprozil and loracarbef.
We conducted a blinded taste test evaluating 12 antimicrobial suspensions by smell, texture, taste, aftertaste and overall acceptance. Drugs received cumulative scores in each category as well as a total score ranking. Overall Lorabid scored highest but not significantly higher than Keflex, Suprax and Ceclor, all of which score higher than the other test drugs. Cefzil and Augmentin scored just below this group of drugs and higher than all other test drugs. Vantin was inferior to these drugs primarily because of its low score in aftertaste. It was ranked along with V-Cillin-K, Veetids, Sulfatrim and Pediazole, the lowest scoring group of drugs other than Dynapen which scored lower than all other test drugs. No difference overall was detected between the two penicillin VK suspensions evaluated, V-Cillin-K and Veetids.
Demers
D M
DM
Department of Pediatrics, Tripler Army Medical Center, Honolulu, HI 96859-5000.
Chan
D S
DS
Bass
J W
JW
D000704:Analysis of Variance; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives; D015296:Ceftizoxime / Q000031:analogs & derivatives; D002511:Cephalosporins; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D006801:Humans; D007223:Infant; D016037:Single-Blind Method; D012903:Smell; D013535:Suspensions; D013649:Taste; D000097623:Cefpodoxime; D000097670:Cefprozil
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D020682:Cefixime; D002439:Cefotaxime; D015296:Ceftizoxime; D002511:Cephalosporins; D004338:Drug Combinations; D013535:Suspensions; D000097623:Cefpodoxime; D000097670:Cefprozil; C054920:loracarbef