title: Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.
abstract: Two new macrolide sesquiterpene pyridine alkaloids, emarginatine F [1] and emarginatine G [2], were isolated from Maytenus emarginata. The structural determinations of 1 and 2 by 2D nmr techniques and spectral comparison with a related compound, emarginatine A [3], are discussed. Biological evaluation showed that emarginatine F [1] demonstrated strong cytotoxicity against human epidermoid carcinoma of the nasopharynx (KB), ileocecal adenocarcinoma (HCT-8), melanoma (RPMI-7951) and medulloblastoma (TE-671) tumor cells, and against murine leukemia (P-388).
authors.affiliation: National Research Institute of Chinese Medicine, Shin-Dain, Taipei Hsien, Taiwan.
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: M L
authors.initials: ML
authors.lastname: King
authors.forename: C F
authors.initials: CF
authors.lastname: Chen
authors.forename: H Y
authors.initials: HY
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C087109:emarginatine F; C087110:emarginatine G