Oncology and hematology.
Net overexpression or derangements of PTK-encoding oncogenes and ras serve as critical driving forces in the evolution of many epithelial and lymphohematopoietic cancers. The ability to impede signal transduction through ras-based pathways could provide a powerful molecular target for therapy and prevention of a broad spectrum of malignant neoplasms.
Karp
J E
JE
National Cancer Institute, Bethesda, Md.
Broder
S
S
D006405:Hematology / Q000639:trends*; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009857:Oncogenes; D014481:United States