[Various changes in the average membrane potential and number of T-lymphocytes in Balb C mice at different physiological states in environments with various levels of D2O].
Influence of different concentrations of D2O upon T-cells of mice in different physiological states of organism was investigated. We have found out, that D2O increases membrane potential (MP) of T-cells in control organism and decreases MP of cells in organisms, where inflammatory process takes place (common reaction to damage, CRD). Volume of T-cells decreases in all states of organism. Influence of large concentrations of D2O (more than 5%) is similar to influence of ouabain. Difference between control and CRD disappears in 100% D2O. We have made a suggestion, that D2O (less than 5%) is the modifier of physiological states of organism.
Vengrus
T V
TV
Zatsepina
G N
GN
Kramskoĭ
M N
MN
Goriunov
N N
NN
D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D017666:Deuterium Oxide / Q000494:pharmacology*; D008564:Membrane Potentials; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D003470:Culture Media; D017666:Deuterium Oxide
Razlichnye izmeneniia srednego membrannogo potentsiala i ob''ema T-limfotsitov mysheĭ linii Balb C, nakhodiashchikhsiia v raznykh fiziologicheskikh sostoianiiakh organizma v sredakh s raznym soderzhaniem D2O.