title: DIACATOR: simulation of metabolic abnormalities of type II diabetes mellitus by use of a personal computer.
abstract: A computer program has been developed to simulate non-insulin-dependent diabetes mellitus (type 2). This disease is characterized by an impaired function of the pancreatic beta-cell and by an insufficient insulin sensitivity of the peripheral tissue. The program simulates the dependences of glucose utilization, glucose production and serum insulin level as a function of glucose and insulin and displays the results as curves on the screen. Six different states of diabetes/glucose intolerance as well as a healthy state can be selected. Renal glucose excretion can be adjusted by selection of the glomerular filtration rate. Action of sulphonylureas are simulated by changing the insulin secretion rate of the beta-cell, biguanides enhance sensitivity of the peripheral tissue for insulin and Acarbose delays glucose absorption from the intestines. Model parameters are taken from the literature. The program can be used for computer-aided medical education and for simulation of special problems in research.
authors.affiliation: Institut für Diabetesforschung und Städt, Krankenhaus Schwabing, München, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Biermann
mesh_terms: D020909:Acarbose; D001645:Biguanides / Q000627:therapeutic use; D003198:Computer Simulation; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008838:Microcomputers; D008954:Models, Biological; D012984:Software; D014312:Trisaccharides / Q000627:therapeutic use
chemical_list: D001645:Biguanides; D007004:Hypoglycemic Agents; D007328:Insulin; D014312:Trisaccharides; D005947:Glucose; D020909:Acarbose