Genomic rearrangement of the alpha-globin gene complex during mammalian evolution.
In man, the gene for hydroxyacyl glutathione hydrolase (HAGH; glyoxalase II) is closely linked to the alpha-globin locus (HB alpha) on Chromosome 16. HAGH polymorphism in the mouse has now enabled the mapping of the murine homologue. Deletion mapping, congenic strain studies, and characterization of 41 recombinant inbred strains establish that the mouse Hagh locus lies very close to the alpha-globin pseudogene (Hba-ps4) in the vicinity of the major histocompatibility locus (H-2) on chromosome 17. Several other loci have been identified previously that are also closely linked to the human alpha-globin locus but near the alpha-globin pseudogene Hba-ps4 in the mouse. These linkage relationships suggest that during the evolution of mice a translocation occurred that subdivided the alpha-globin locus, leaving one inactive alpha-globin gene still associated with the Hagh locus and linked sequences, while moving and inserting the active alpha-globin locus and all distal sequences into an internal location on another autosome, the predecessor to mouse chromosome 11.
Tan
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Department of Biochemistry & Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
Whitney
J B
JB
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D014644:Genetic Variation; D016678:Genome; D005914:Globins / Q000235:genetics*; D015186:Hominidae / Q000235:genetics; D006801:Humans; D007525:Isoelectric Focusing; D008322:Mammals / Q000235:genetics; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D013045:Species Specificity; D013869:Thiolester Hydrolases / Q000235:genetics; D000099301:Hydroxyacylglutathione Hydrolase
D005914:Globins; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase