title: Epidemic optic neuropathy in Cuba. Eye findings.
abstract: OBJECTIVE
  To characterize and establish a clinical definition of the optic neuropathy that appeared in epidemic form in Cuba in 1992 and 1993.
  
  
  METHODS
  At the invitation of the Cuban Ministry of Health, Havana, members of ORBIS International and the Pan American Health Organization, assembled teams that traveled to Cuba in May 1993. We were initially briefed by Cuban national experts in the areas of virology, nutrition, toxicology, ophthalmology, neurology, and public health. We then examined 20 patients on our own. Thirteen of these patients underwent a comprehensive neuro-ophthalmologic examination, including neurologic examination, ophthalmologic examination, visual fields, optic nerve function studies, contrast sensitivity studies, and funduscopy. We returned 4 months later to perform an additional 12 comprehensive neuro-ophthalmologic and follow-up examinations.
  
  
  RESULTS
  Only seven of the 13 patients who were alleged to have the optic form of the epidemic and who were rigorously and systematically examined on the first visit demonstrated a bilateral optic neuropathy. These seven patients had several features that included decreased visual acuity, poor color vision, central scotomas, decreased contrast sensitivity, saccadic eye movements, and most prominent and distinctive of all, nerve fiber layer wedge defects of the papillomacular bundle. Our clinical definition was then implemented by the Cuban ophthalmologists and epidemiologists. On returning 4 months later, we found that all newly presented patients were correctly diagnosed to have the epidemic disease. With the new case definition and the application of a few simple psychophysical tests, the false-positive rate of diagnosis became much lower. After vitamin therapy, we reexamined the patients seen on our initial visit, and all showed marked improvement.
  
  
  CONCLUSIONS
  The Cuban epidemic was characterized by an optic neuropathy with features that were similar to those of tobacco/alcohol amblyopia and Leber's optic atrophy. Recent political, economic, and social changes in Cuba may have contributed to the nutritional and/or toxic compromise of mitochondrial function of an acquired nature, which led to selective retinal ganglion cell damage. We have termed this condition Cuban epidemic optic neuropathy.
authors.affiliation: ORBIS International, New York, NY.
authors.forename: A A
authors.initials: AA
authors.lastname: Sadun
authors.forename: J F
authors.initials: JF
authors.lastname: Martone
authors.forename: R
authors.initials: R
authors.lastname: Muci-Mendoza
authors.forename: L
authors.initials: L
authors.lastname: Reyes
authors.forename: L
authors.initials: L
authors.lastname: DuBois
authors.forename: J C
authors.initials: JC
authors.lastname: Silva
authors.forename: G
authors.initials: G
authors.lastname: Roman
authors.forename: B
authors.initials: B
authors.lastname: Caballero
mesh_terms: D000328:Adult; D003462:Cuba / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D015994:Incidence; D008297:Male; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy