title: Low-level sensory processing in obsessive-compulsive disorder: an evoked potential study.
abstract: This study used visual and auditory evoked potentials (VEP and AEP) to study low-level sensory processing in a group of 15 unmedicated subjects with obsessive-compulsive disorder (OCD) and 30 age-matched, gender-matched, and handedness-matched normal controls. EPs were recorded to flash (VEP) and binaural click (AEP) stimulation. OCD subjects were found to have significantly shorter latencies on N1 and P2 of the AEP, and no differences were found in the VEP. Results indicate abnormal information processing states in OCD during low-level auditory processing, but not during low-level visual processing. Neural generators of the VEP and AEP are briefly reviewed and results are discussed in relation to current neurobiological models of OCD.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129.
authors.forename: C R
authors.initials: CR
authors.lastname: Savage
authors.forename: J B
authors.initials: JB
authors.lastname: Weilburg
authors.forename: F H
authors.initials: FH
authors.lastname: Duffy
authors.forename: L
authors.initials: L
authors.lastname: Baer
authors.forename: D M
authors.initials: DM
authors.lastname: Shera
authors.forename: M A
authors.initials: MA
authors.lastname: Jenike
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001921:Brain / Q000503:physiopathology; D004558:Electric Stimulation; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology / Q000523:psychology*; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology