[The effect of acetylcholine on neuromuscular transmission in the fatigued rat diaphragm with blocked acetylcholinesterase].
The rat phrenic-diaphragm preparations with amine-inhibited acetylcholinesterase were fatigued by rhythmical nerve stimulation. Tetanization of the nerve by bursts of stimuli 20/sec led to a long-term recovery of muscle contractions of the fatigued muscles. The recovery was completely abolished by tubocurarine and partially--by atropine. Acetylcholine bathing simulated the effect of tetanization. Probable mechanisms of this phenomenon are discussed.
Kubasov
I V
IV
Krivoĭ
I I
II
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003964:Diaphragm / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D000109:Acetylcholine
Vliianie atsetilkholina na nervno-myshechnuiu peredachu v utomlennoĭ diafragme krysy s blokirovannoĭ atsetilkholinésterazoĭ.