Acquired type II protein C deficiency in a long-term hemodialysis patient.
We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreased protein C activity despite a normal protein C antigen level. None of his relatives had decreased protein C activity, and the levels of the other coagulation factors synthesized by the liver were all normal. Accordingly, the patient was diagnosed as having acquired type II protein C deficiency.
Maruyama
H
H
Department of Medicine (II), Niigata University School of Medicine, Japan.
Gejyo
F
F
Hanano
M
M
Arakawa
M
M
D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020151:Protein C Deficiency; D006435:Renal Dialysis / Q000009:adverse effects*; D013924:Thrombophlebitis / Q000209:etiology