title: Pseudorheumatoid nodule (deep granuloma annulare) of childhood: clinicopathologic features of twenty patients.
abstract: Pseudorheumatoid nodule of childhood is seen uncommonly by pathologists and is thought to be a variant of granuloma annulare. We report a series of 20 patients (13 M, 7 F) age 1 to 17 years. Fourteen lesions arose on the front of the lower limb, and 14 children had numerous lesions at diagnosis. Seven developed some form of recurrence, except for one case occurring at the site of the original lesion. Only one patient had a weakly positive rheumatoid factor, and was the patient with remote recurrence. As a significant number of lesions arose around the foot when the child was beginning to walk or starting to wear shoes, it is suggested that trauma plays a role in the development of some of these lesions.
authors.affiliation: Department of Pathology, Aberdeen University, United Kingdom.
authors.forename: M J
authors.initials: MJ
authors.lastname: Evans
authors.forename: K
authors.initials: K
authors.lastname: Blessing
authors.forename: E S
authors.initials: ES
authors.lastname: Gray
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003094:Collagen; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D016460:Granuloma Annulare / Q000473:pathology*; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012218:Rheumatoid Nodule / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D003094:Collagen