Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).
McCarthy
P A
PA
Central Research, Pfizer Inc., Groton, Connecticut 06340.
Hamanaka
E S
ES
Marzetta
C A
CA
Bamberger
M J
MJ
Gaynor
B J
BJ
Chang
G
G
Kelly
S E
SE
Inskeep
P B
PB
Mayne
J T
JT
Beyer
T A
TA
D000634:Aminoquinolines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002784:Cholesterol / Q000097:blood; D004285:Dogs; D006801:Humans; D008862:Microsomes, Liver / Q000201:enzymology; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
D000634:Aminoquinolines; D011725:Pyridines; C087133:N-(6-(methylthio)quinolin-5-yl)-2-(hexylthio)decanoic acid amide; C087132:CP 113818; D002784:Cholesterol; D002785:Sterol O-Acyltransferase