title: Enhancement of serotonergic immunoreactivity in sympathetic cerebrovascular nerve fibers after experimental embolic stroke.
abstract: We examined 5-hydroxytryptamine-like immunoreactive cerebrovascular nerve fibers in rats after experimental thromboembolic stroke. Although there were no visible 5-hydroxytryptamine-like immunoreactive nerve fibers in normal animals, we found many of these fibers near the clot emboli 30 min after the stroke, and the number of fibers increased slightly with time. In immunohistochemical double staining, these fibers corresponded to neuropeptide Y-like immunoreactive nerve fibers. And they were not observed in animals after superior cervical ganglionectomy. These findings suggest that the sympathetic nerves take up serotonin released from intraluminal aggregating platelets.
authors.affiliation: Department of Neurosurgery, Yamaguchi University School of Medicine, Ube-shi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: R
authors.initials: R
authors.lastname: Kishida
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: H
authors.initials: H
authors.lastname: Ito
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D015171:Ganglionectomy; D007150:Immunohistochemistry; D002542:Intracranial Embolism and Thrombosis / Q000473:pathology*; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure*; D009478:Neuropeptide Y / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000276:immunology / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000166:cytology / Q000473:pathology*
chemical_list: D009478:Neuropeptide Y; D012701:Serotonin