title: [Long-term results of echographically guided percutaneous ethanol injection in the treatment of the autonomous thyroid nodule].
abstract: Ultrasound-guided percutaneous ethanol injection (PEI) was performed as a therapeutic procedure on twenty-four patients affected by toxic autonomously functioning thyroid nodules (AFTN). After treatment patients were followed up for a mean period of 12 months. PEI induced persistent and complete (clinical and hormonal) disease control in 19/23 cases (82.6%) that completed the procedure, normalization of serum FT4 and FT3 associated with a still suppressed TSH in 2/23 cases (8.6%) and failed to control hyperthyroidism in 2/23 cases (8.6%). After PEI all AFTN became smaller at clinical and US examination with a 60% mean volume decrease. Nodule shrinkage was related to cytological and histological findings of well circumscribed coagulative necrosis, granulomatous inflammation and progressive fibrosis. PEI induced two cases of temporary complications: 1 case of acute worsening of thyrotoxicosis and 1 case of self-resolving vocal cord paresis. No increase of serum autoantibodies (TgAb, TPOAb, TRAb) was detected during the follow-up period.
authors.affiliation: Sezione di Endocrinologia e Malattie del Metabolismo, Ospedale Regina Apostolorum, Albano Laziale, Roma.
authors.forename: E
authors.initials: E
authors.lastname: Papini
authors.forename: C
authors.initials: C
authors.lastname: Panunzi
authors.forename: L
authors.initials: L
authors.lastname: Petrucci
authors.forename: R
authors.initials: R
authors.lastname: Rinaldi
authors.forename: R
authors.initials: R
authors.lastname: Tramutoli
authors.forename: G
authors.initials: G
authors.lastname: Pisicchio
authors.forename: F
authors.initials: F
authors.lastname: Nardi
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology / Q000628:therapy; D007267:Injections / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D013954:Thyroglobulin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D016606:Thyroid Nodule / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D013971:Thyrotoxicosis / Q000209:etiology; D013972:Thyrotropin / Q000097:blood; D016896:Treatment Outcome; D014463:Ultrasonography; D014826:Vocal Cord Paralysis / Q000209:etiology
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; D000431:Ethanol; D013972:Thyrotropin; D013954:Thyroglobulin
vernacular_title: Risultati a lungo termine dell'iniezione percutanea di etanolo sotto guida ecografica (PEI) nel trattamento del nodulo autonomo tiroideo.