title: Sequential positron emission tomographic evaluations of brain metabolism in acute herpes encephalitis.
abstract: This first known positron emission tomography report on metabolic changes in acute herpes simplex virus (HSV-1) encephalitis demonstrates focal hypermetabolism in areas of cerebral cortex adjacent to actively inflamed hippocampus acutely infected with HSV-1. When neuropsychiatric symptoms recurred in a previously healthy 61-year-old patient 1 month after recovering from acute HSV-1 encephalitis, repeat positron emission tomography with fluorodeoxyglucose was helpful in ruling out recurrent active infection by showing marked hypometabolism throughout the previously infected temporal lobe.
authors.affiliation: University of Tennessee Medical Center, Biomedical Imaging Center, Knoxville, TN 37920.
authors.forename: M A
authors.initials: MA
authors.lastname: Meyer
authors.forename: K F
authors.initials: KF
authors.lastname: Hubner
authors.forename: S
authors.initials: S
authors.lastname: Raja
authors.forename: K
authors.initials: K
authors.lastname: Hunter
authors.forename: W A
authors.initials: WA
authors.lastname: Paulsen
mesh_terms: D000208:Acute Disease; D001921:Brain / Q000378:metabolism*; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006561:Herpes Simplex / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed