[A case of progressive multifocal leucoencephalopathy during chronic lymphocytic leukaemia].
We report here a case of PML in the course of untreated chronic lymphocytic leukaemia. The diagnosis of PML was based on the presence of typical histologic findings in the white matter: focal demyelination, abnormal oligodendroglia with basophilic intranuclear inclusions and enlarged bizarre astrocytes. It was confirmed by immunohistochemistry which revealed JC papova-virus antigens in brain tissue and by in-situ hybridization which showed JC virus genomic DNA in oligodendroglial nuclei. Virus particles in the nuclei of abnormal oligodendrocytes and astrocytes were demonstrated by thin-section electron-microscopy.
Nowak-Michalska
T
T
Kliniki Neurologicznej II Wydz. Lek. AM, Warszawie.
Barcikowska
M
M
Kida
E
E
Budka
H
H
Liberski
P P
PP
D000368:Aged; D001253:Astrocytes / Q000276:immunology / Q000648:ultrastructure; D001921:Brain / Q000276:immunology; D004279:DNA, Viral; D003711:Demyelinating Diseases; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007577:JC Virus / Q000302:isolation & purification; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000276:immunology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D008854:Microscopy, Electron; D009836:Oligodendroglia / Q000276:immunology / Q000648:ultrastructure; D027383:Papillomaviridae / Q000302:isolation & purification; D027382:Polyomaviridae; D014057:Tomography, X-Ray Computed
D004279:DNA, Viral
Przypadek postepujacej wieloogniskowej leukoencefalopatii w przebiegu przewlekłej białaczki limfatycznej.