[The role of hepatocytes, Kupffer, and endothelial cells of the liver in blood lipoprotein metabolism].
The rates of blood lipoprotein adsorption by hepatocytes and nonparenchymal cells (NPC) of rat liver have been quantitatively characterized. It was found that the lipoprotein-adsorbing capacity of NPC is higher than that of hepatocytes: 5.6 times for very low density lipoproteins (VLDL), 4.3 times for low density lipoproteins (LDL) and 14.4 times for high density lipoproteins. Stimulation of the mononuclear phagocyte system by a lipopolysaccharide from Serratia marcescens resulted in a significant reduction of blood serum levels of HDL3, LDL and glucocorticoids. Under these conditions the binding of [125I]HDL to hepatocytes increased, while that to Kupffer's cells decreased considerably. In response to stimulation of liver resident macrophages (Kupffer's cells) the rate of protein biosynthesis in hepatocytes increased together with an increase in the rate of [14C]leucine incorporation into the protein component of the blood serum lipoproteins. Enhanced gene expression in the hepatocytes seems to be associated with the cooperative action of HDL and glucocorticoids. Adsorption of lipoproteins by activated Kupffer's cells is due to the receptor-mediated endocytosis, resulting in a decrease of the binding capacity of these cells for HDL and LDL.
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D000818:Animals; D004705:Endocytosis; D004727:Endothelium / Q000166:cytology / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000097:blood; D007728:Kupffer Cells / Q000166:cytology / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005938:Glucocorticoids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL
Rol' gepatotsitov, kupferovskikh i éndotelial'nykh kletok pecheni v obmene lipoproteidov krovi.