[Therapy of isolated acute laryngitis with fusafungin. A phase IV study].
Four-hundred and eighty-four patients with acute laryngitis were examined before and after treatment with fusafungin under phase IV conditions. After one week of therapy such complaints as hoarseness, sore throat and difficulties in swallowing were improved in about 90% of the patients, while the leading complaint of "hoarseness" had disappeared in 60%. Inflammatory findings, documented by a physician, showed comparable results. An analysis of subgroups (ineffectively treated patients and patients with long-lasting symptoms and complaints) shows that fusafungin was effective therapeutically for treating for acute laryngitis. This study also shows that the generally accepted high rate of spontaneous recovery does not exist.
Hamann
K F
KF
HNO-Klinik und Poliklinik des Klinikums rechts der Isar, Technischen Universität München.
D000208:Acute Disease; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols / Q000009:adverse effects / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D047630:Depsipeptides; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005670:Fusarium; D006801:Humans; D007827:Laryngitis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000336:Aerosols; D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C014001:fusafungin
Therapie der isolierten akuten Laryngitis mit Fusafungin. Eine Phase-IV-Studie.