Elevated plasma kynurenine in Tourette syndrome.
Fasting plasma kynurenine concentrations were significantly elevated in a group of 7 patients (4 female) conforming to DSM-III-R of the American Psychiatric Association (1987) criteria for Tourette syndrome, in comparison with 10 healthy controls (7 female). Simultaneous normal plasma biopterin and neopterin concentrations indicated that this rise was probably not a consequence of peripheral cellular immune mechanisms.
Dursun
S M
SM
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
Farrar
G
G
Handley
S L
SL
Rickards
H
H
Betts
T
T
Corbett
J A
JA
D000293:Adolescent; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007737:Kynurenine / Q000097:blood*; D008297:Male; D019798:Neopterin; D012016:Reference Values; D005879:Tourette Syndrome / Q000097:blood*; D014364:Tryptophan / Q000097:blood
D001708:Biopterins; D007737:Kynurenine; D019798:Neopterin; D014364:Tryptophan