Amyloid-P-component-like immunoreactivity in beta/A4-immunoreactive deposits in Alzheimer-type dementia brains.
An immunohistochemical study using the mirror-image technique was performed in order to establish whether amyloid P component is involved in the mechanism of deposition of amyloid fibrils in senile plaques (SPs) in Alzheimer-type dementia (ATD). Ninety percent of beta/A4 protein-immunoreactive SPs were also stained by the anti-amyloid P component immunohistochemistry, and this applied to all of the diffuse, primitive and classical types of beta/A4 deposits. These findings may suggest an involvement of amyloid P component in the formation of amyloid fibrils in senile plaques in ATD brains.
Kimura
M
M
Department of Psychiatry, Juntendo University School of Medicine, Saitama, Japan.
Arai
H
H
Takahashi
T
T
Iwamoto
N
N
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000032:analysis* / Q000378:metabolism; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D006801:Humans; D011499:Protein Processing, Post-Translational; D000683:Serum Amyloid P-Component / Q000032:analysis*
D016564:Amyloid beta-Protein Precursor; D000683:Serum Amyloid P-Component