Inflammatory pain: the role of cytokines and its control by drugs which release nitric oxide.
We are progressing towards an understanding of the mechanism of peripherally acting analgesics. Knowledge of the participation of the cytokines in inflammatory hyperalgesia and the involvement of the arginine-NO-cGMP pathway in the mechanism of agents which directly down-regulate ongoing hyperalgesia may provide for better therapeutic approaches and permit the development of novel analgesics.
Ferreira
S H
SH
Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D001120:Arginine / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D016207:Cytokines / Q000502:physiology*; D015536:Down-Regulation; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D013565:Sympatholytics / Q000627:therapeutic use
D000700:Analgesics; D016861:Cyclooxygenase Inhibitors; D016207:Cytokines; D013565:Sympatholytics; D009569:Nitric Oxide; D001120:Arginine; D006152:Cyclic GMP