title: Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1.
abstract: To identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers only those with a diagnosis of schizophrenia or schizoaffective disorder as affected, a random search of the genome for detection of linkage was undertaken. Pairwise linkage analyses suggest a potential linkage (LRH = 34.7 or maximum lod score = 1.54) for one region (22q12-q13.1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies.
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore 21231.
authors.forename: A E
authors.initials: AE
authors.lastname: Pulver
authors.forename: M
authors.initials: M
authors.lastname: Karayiorgou
authors.forename: P S
authors.initials: PS
authors.lastname: Wolyniec
authors.forename: V K
authors.initials: VK
authors.lastname: Lasseter
authors.forename: L
authors.initials: L
authors.lastname: Kasch
authors.forename: G
authors.initials: G
authors.lastname: Nestadt
authors.forename: S
authors.initials: S
authors.lastname: Antonarakis
authors.forename: D
authors.initials: D
authors.lastname: Housman
authors.forename: H H
authors.initials: HH
authors.lastname: Kazazian
authors.forename: D
authors.initials: D
authors.lastname: Meyers
mesh_terms: D000328:Adult; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010552:Personality Assessment; D012044:Regression Analysis; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D005819:Genetic Markers