HLA and T cell receptor beta-chain DNA polymorphisms identify a distinct subset of patients with pauciarticular-onset juvenile rheumatoid arthritis.
OBJECTIVE
To evaluate and extend upon a reported association of a T cell receptor (TCR) V beta coding region polymorphism with pauciarticular-onset juvenile rheumatoid arthritis (JRA).


METHODS
TCR V beta 6.1 genotypes and haplotypes in JRA and control groups were determined by DNA amplification.


RESULTS
Haplotypes of the V beta 6.1 gene which encode a nonfunctional form of V beta 6.1 were significantly associated with pauciarticular JRA in patients possessing the HLA-DQA1*0101 allele (P = 0.0073).


CONCLUSIONS
A TCR V beta gene segment in the vicinity of V beta 6.1, possibly V beta 6.1, is apparently involved in the pathogenesis of pauciarticular-onset JRA in DQA1*0101-positive individuals.
Charmley
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Virginia Mason Research Center, Seattle, Washington 98101.
Nepom
B S
BS
Concannon
P
P
D001171:Arthritis, Juvenile / Q000276:immunology*; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D005784:Gene Amplification; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D010375:Pedigree; D017354:Point Mutation; D011110:Polymorphism, Genetic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
D006680:HLA Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D004247:DNA