title: Effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals.
abstract: The effects of ferric chloride and deferoxamine, an iron chelator, on cisplatin-induced emesis were studied in Suncus murinus. Pretreatment with ferric chloride (FeCl3, 16-64 mg/kg) increased the number of 20 mg/kg cisplatin-induced vomiting episodes. Deferoxamine (256 mg/kg) significantly reduced the number of vomiting episodes and prolonged the latency. These results further support the involvement of free radicals in the generation of cisplatin-induced emesis.
authors.affiliation: Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsuki
authors.forename: Y
authors.initials: Y
authors.lastname: Torii
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000818:Animals; D002712:Chlorides; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D003676:Deferoxamine / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology*; D005609:Free Radicals; D007274:Injections, Intraperitoneal; D012788:Shrews; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D002712:Chlorides; D005290:Ferric Compounds; D005609:Free Radicals; D003676:Deferoxamine; D002945:Cisplatin; C024555:ferric chloride