Obstetrical advantages and perinatal risks of indomethacin: a report of 818 cases.
In a series of 818 patients treated with indomethacin during pregnancy, the rate of perinatal complications was 1.8%. The risk was increased to 13% if indomethacin was being taken at the time of delivery, and when treatment was prolonged. The serious nature of certain complications (persistence of fetal circulation and oligo/anuria) means that indomethacin should only be used in cases in which betamimetic drugs are formally contraindicated or if there is a risk of unacceptable prematurity. Even in such cases, indomethacin should only be given for short period (< 1 week).
Marpeau
L
L
Clinique de gynécologie obstétrique, CHU St. Antoine, Paris, France.
Bouillie
J
J
Barrat
J
J
Milliez
J
J
D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors
D007213:Indomethacin