Long term follow up of patients with IgA nephropathy.
OBJECTIVE
To assess the long term outcome of patients with IgA nephropathy.


METHODS
The outcome of 151 patients (120 male; mean age 32.5, median age 29.6, SD 15.4 years; 146 Caucasian) with biopsy-proven IgA nephropathy. The patients were enrolled between 30 April 1973 and 21 August 1992.


RESULTS
Ninety-five (63%) of the patients presented with microscopic haematuria, with or without proteinuria and/or renal insufficiency. At presentation renal insufficiency was present in 34% and hypertension in 48% of patients. During a mean follow up period of 63.3 months (range 0-233 months) 12 patients have reached end stage renal failure, five have died of a nonrenal cause and 25 were lost to follow up. The actuarial renal survival rate was 92.6% at five years and 91.1% at both 10 and 15 years. A significantly poorer renal survival rate was seen in those patients with a plasma creatinine > or = 0.12 mmol/L, hypertension, a serum albumin of < 35 g/L, or a 24 hour urinary albumin excretion > or = 1.0 g at presentation, and this became apparent within the first few years of follow up.


CONCLUSIONS
The long term outcome of IgA nephropathy is better than previously reported. Those patients with a poor prognosis can be identified with considerable certainty at presentation.
Bailey
R R
RR
Department of Nephrology, Christchurch Hospital.
Lynn
K L
KL
Robson
R A
RA
Smith
A H
AH
Wells
J E
JE
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000208:ethnology / Q000401:mortality*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology; D017678:Sex Distribution; D016019:Survival Analysis; D015996:Survival Rate; D044465:White People