Nasopharyngeal carcinoma: histopathological types and association with Epstein-Barr Virus.
The polymerase chain reaction was used to examine paraffin-embedded tissues of 37 nasopharyngeal carcinomas (NPC) for Epstein-Barr virus (EBV) genomic sequences. EBV DNA was found in 2/14 keratinising squamous cell (WHO 1) carcinomas and in all of 23 non-keratinising and undifferentiated (WHO 2 and 3) NPC. The study confirms the infrequent association of keratinising NPC and EBV, in contrast with the 100% association of the less differentiated NPCs and the virus. The results may indicate a different carcinogenesis for the WHO 1 NPC subtype.
Hørding
U
U
Department of Gynaecology and Obstetrics, University Hospital, Copenhagen, Denmark.
Nielsen
H W
HW
Albeck
H
H
Daugaard
S
S
D002277:Carcinoma / Q000382:microbiology*; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D003043:Cocarcinogenesis; D004279:DNA, Viral / Q000032:analysis; D003718:Denmark; D006116:Greenland; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D015151:Immunoblotting; D004930:Inuit; D009303:Nasopharyngeal Neoplasms / Q000382:microbiology*; D016133:Polymerase Chain Reaction
D004279:DNA, Viral