title: Tibial hemimelia and tetralogy of Fallot associated with first trimester exposure to amantadine.
abstract: Although amantadine hydrochloride has been extensively used for the prevention of influenza A2, few data exist regarding its safety in pregnancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 29 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follow-up of the four prospective cases known to date to the Motherisk Program in Toronto did not identify any abnormalities.
authors.affiliation: Department of Neonatology, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: P B
authors.initials: PB
authors.lastname: Pandit
authors.forename: D
authors.initials: D
authors.lastname: Chitayat
authors.forename: A L
authors.initials: AL
authors.lastname: Jefferies
authors.forename: A
authors.initials: A
authors.lastname: Landes
authors.forename: I U
authors.initials: IU
authors.lastname: Qamar
authors.forename: G
authors.initials: G
authors.lastname: Koren
mesh_terms: D000014:Abnormalities, Drug-Induced; D000328:Adult; D000547:Amantadine / Q000009:adverse effects*; D004480:Ectromelia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013771:Tetralogy of Fallot / Q000139:chemically induced*; D013977:Tibia / Q000002:abnormalities*
chemical_list: D000547:Amantadine