title: Synthesis and anticonvulsant activity of new dibenzo[1,2]thiazepine S,S-dioxides.
abstract: A new series of 11-substituted 6,11-dihydro-6-methyl-dibenzo[c,f]-[1,2]thiazepine S,S-dioxides was synthesized. Some of the components show significant anticonvulsant activity in the MES, pentetrazol and strychnine tests. The more active compounds are devoid of neurotoxic effects.
authors.affiliation: Instituto de Química Médica, CSIC, Juan de la Cierva, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Diaz
authors.forename: E
authors.initials: E
authors.lastname: Montero
authors.forename: S
authors.initials: S
authors.lastname: Vega
authors.forename: V
authors.initials: V
authors.lastname: Darias
authors.forename: M L
authors.initials: ML
authors.lastname: Tello
authors.forename: S S
authors.initials: SS
authors.lastname: Abdallah
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D003987:Dibenzothiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D013055:Spectrophotometry, Infrared
chemical_list: D000927:Anticonvulsants; D003987:Dibenzothiazepines