Developmental toxicity evaluation of piperonyl butoxide in CD-1 mice.
Piperonyl butoxide was administered to pregnant mice by gavage at a level of 0 (control), 1065, 1385 and 1800 mg/kg body weight only on day 9 of gestation. The animals were sacrificed on day 18 of gestation. Early and late foetal deaths were significantly increased in the higher dose groups and those effects were significantly dose-related. The average body weights of male and female foetuses were significantly reduced in a dose-related fashion. The external malformation of oligodactyly in forelimbs was significantly increased in higher treatment groups in a dose-related manner. The dose levels of piperonyl butoxide in the present study produced adverse effects on developmental parameters.
Tanaka
T
T
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Fujitani
T
T
Takahashi
O
O
Oishi
S
S
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005552:Forelimb / Q000002:abnormalities*; D005865:Gestational Age; D008297:Male; D051379:Mice; D010882:Piperonyl Butoxide / Q000008:administration & dosage / Q000633:toxicity*
D010882:Piperonyl Butoxide