Synthesis and antihepatotoxic activity of silybin 11-O-phosphate.
Silybin 11-O-phosphate 3 was synthesized by selective phosphorylation of silybin with POCl3. The pharmacological activity of 3 was evaluated in the rat by using the praseodymium poisoning test. Preliminary results showed that the compound possesses antihepatotoxic activity, possibly with lower potency compared to the reference drug silybin hemisuccinate.
Pifferi
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Istituto di Chimica Farmaceutica e Tossicologia, Università di Milano, Italy.
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D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009929:Organ Size; D010755:Organophosphates / Q000138:chemical synthesis* / Q000494:pharmacology; D011221:Praseodymium / Q000506:poisoning; D051381:Rats; D017208:Rats, Wistar; D000077385:Silybin; D012838:Silymarin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D010755:Organophosphates; D012838:Silymarin; C087301:silybin 11-O-phosphate; D000077385:Silybin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011221:Praseodymium