Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas.
This study investigated the immunohistochemical expression of human placental glutathione S-transferase (GST-pi) in the epithelium of oral premalignant and malignant lesions. Epithelial lining of normal oral mucosa, hyperplastic lesions and oral epithelium exhibiting mild dysplasia showed weak to moderate GST-pi staining. Moderate epithelial dysplasia revealed an increased antibody content while severe dysplasia, carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC) demonstrated markedly increased antibody binding. The GST-pi staining was evident mainly in the cytoplasm. Severe dysplasia, CIS and SCC were also characterized by areas of cells with intensive nuclear GST-pi staining. These findings support the hypothesis that GST-pi plays a role in human oral carcinogenesis and may be used as a tumor marker for human oral premalignant and malignant lesions.
Zhang
L
L
Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Xiao
Y
Y
Priddy
R
R
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000032:analysis*; D002278:Carcinoma in Situ / Q000201:enzymology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D004848:Epithelium / Q000201:enzymology / Q000473:pathology; D005326:Fetal Proteins / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D006965:Hyperplasia / Q000201:enzymology / Q000473:pathology; D007124:Immunoenzyme Techniques; D009061:Mouth Mucosa / Q000201:enzymology / Q000473:pathology; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology; D011230:Precancerous Conditions / Q000201:enzymology* / Q000473:pathology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D005326:Fetal Proteins; D005982:Glutathione Transferase