title: Rapid appearance of severe mitral regurgitation under high-dosage corticosteroid therapy in a patient with systemic lupus erythematosus.
abstract: Survival of patients with systemic lupus erythematosus has increased with corticosteroid therapy. However, adverse effects of corticosteroid therapy on cardiovascular structures, such as scarring and shrinking of affected valves, are not well known. We report the case of a 19-year-old patient who developed severe mitral insufficiency within a few weeks after high-dosage corticosteroid therapy had been instituted for an acute relapse of systemic lupus erythematosus. The rapid development of severe mitral regurgitation was documented by sequential colour Doppler echocardiography.
authors.affiliation: Medical Clinic II, Klinikum RWTH Aachen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Hoffman
authors.forename: H
authors.initials: H
authors.lastname: Lethen
authors.forename: U
authors.initials: U
authors.lastname: Zunker
authors.forename: F A
authors.initials: FA
authors.lastname: Schöndube
authors.forename: N
authors.initials: N
authors.lastname: Maurin
authors.forename: H G
authors.initials: HG
authors.lastname: Sieberth
mesh_terms: D000328:Adult; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008943:Mitral Valve / Q000187:drug effects; D008944:Mitral Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011239:Prednisolone