The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins.
We have characterized a new human gene, named GARP, localized in the 11q14 chromosomal region. GARP comprises two coding exons, is expressed as two major transcripts of 4.4 and 2.8 kilobases, respectively, and encodes a putative transmembrane protein of 662 amino acids, the extracellular portion of which is almost entirely made of leucine-rich repeats. The molecular weight of the protein immunoprecipitated from transfected cells is 80,000. The GARP protein has structural similarities with the human GP Ib alpha and GP V platelet proteins, and with the Chaoptin, Toll, and Connectin adhesion molecules of Drosophila.
Ollendorff
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V
Laboratoire d'Oncologie Moléculaire, Institut National de la Santé et de la Recherche Médicale, Marseille, France.
Noguchi
T
T
deLapeyriere
O
O
Birnbaum
D
D
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D064211:Connectin; D018076:DNA, Complementary / Q000032:analysis; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D005091:Exons; D015723:Gene Library; D006801:Humans; D007301:Insect Hormones / Q000737:chemistry; D007930:Leucine; D008562:Membrane Glycoproteins / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009124:Muscle Proteins / Q000737:chemistry; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry; D011494:Protein Kinases; D011956:Receptors, Cell Surface; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D051193:Toll-Like Receptors; D014158:Transcription, Genetic; D014162:Transfection
D064211:Connectin; D018076:DNA, Complementary; D029721:Drosophila Proteins; D007301:Insect Hormones; C087215:LRRC32 protein, human; C484196:Lrrc32 protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; C577285:TTN protein, human; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C055093:chp protein, Drosophila; D011494:Protein Kinases; D007930:Leucine