title: Design of orally active, non-peptidic inhibitors of human leukocyte elastase.
authors.affiliation: Department of Medicinal Chemistry, ZENECA Pharmaceuticals Group, Wilmington, Delaware 19897.
authors.forename: F J
authors.initials: FJ
authors.lastname: Brown
authors.forename: D W
authors.initials: DW
authors.lastname: Andisik
authors.forename: P R
authors.initials: PR
authors.lastname: Bernstein
authors.forename: C B
authors.initials: CB
authors.lastname: Bryant
authors.forename: C
authors.initials: C
authors.lastname: Ceccarelli
authors.forename: J R
authors.initials: JR
authors.lastname: Damewood
authors.forename: P D
authors.initials: PD
authors.lastname: Edwards
authors.forename: R A
authors.initials: RA
authors.lastname: Earley
authors.forename: S
authors.initials: S
authors.lastname: Feeney
authors.forename: R C
authors.initials: RC
authors.lastname: Green
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001682:Biological Availability; D006224:Cricetinae; D015195:Drug Design; D006801:Humans; D019272:Leukocyte Elastase; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats
chemical_list: D009842:Oligopeptides; D011744:Pyrimidinones; C069695:ICI 200880; C087135:2-(4-fluorophenyl)-5-((methoxycarbonyl)amino)pyrimidin-4-one-3-ethanoylvaline-trifluoromethylketone; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase