title: Morphine induced, behavioural, biochemical and immunological correlations.
abstract: Tolerance and dependence on morphine appear more or less simultaneously. Evidence has accumulated that addiction leads to depressed immune function and seem to suggest that dependence is under genetic influence. Morphine and related substances of abuse open perspective on ways to investigate the basic mechanisms related to their cellular and systemic effects.
authors.affiliation: Department of Clinical Pharmacology, Medical School, Avondale, Harare, Zimbabwe.
authors.forename: N Z
authors.initials: NZ
authors.lastname: Nyazema
mesh_terms: D000818:Animals; D004361:Drug Tolerance / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009020:Morphine / Q000494:pharmacology* / Q000633:toxicity; D009021:Morphine Dependence / Q000235:genetics / Q000503:physiopathology; D015213:Neuroimmunomodulation / Q000187:drug effects*; D051381:Rats
chemical_list: D009020:Morphine