[Occupational exposure to chemical substances and congenital anomalies: state of the art].
Several thousands of compounds with a potential reproductive toxicity have been identified in animals, some of them are teratogens. In humans, only a small number of chemicals, administered as drugs, present in the diet, or in the occupational environment are recognized human teratogens. In parallel, about 60% of congenital anomalies have no identified cause and most probably some compounds present in the environment may contribute to certain anomalies. This paper presents a review of published epidemiological studies on the association between occupational exposures and congenital anomalies, focusing more particularly on some groups of compounds or some occupations such as: anaesthetic gases, laboratory work, solvents, pesticides and lead.
Cordier
S
S
INSERM U. 170, Villejuif.
Goujard
J
J
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000382:Agricultural Workers' Diseases / Q000139:chemically induced; D000777:Anesthetics / Q000633:toxicity; D000818:Animals; D005260:Female; D006282:Health Personnel; D006801:Humans; D007231:Infant, Newborn; D007855:Lead Poisoning / Q000150:complications; D008297:Male; D016273:Occupational Exposure; D010575:Pesticides / Q000633:toxicity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D012997:Solvents / Q000633:toxicity; D013723:Teratogens
D000777:Anesthetics; D010575:Pesticides; D012997:Solvents; D013723:Teratogens
Expositions professionnelles à des substances chimiques et anomalies congénitales: état des connaissances.