Design of orally active, non-peptidic inhibitors of human leukocyte elastase.
Brown
F J
FJ
Department of Medicinal Chemistry, ZENECA Pharmaceuticals Group, Wilmington, Delaware 19897.
Andisik
D W
DW
Bernstein
P R
PR
Bryant
C B
CB
Ceccarelli
C
C
Damewood
J R
JR
Edwards
P D
PD
Earley
R A
RA
Feeney
S
S
Green
R C
RC
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001682:Biological Availability; D006224:Cricetinae; D015195:Drug Design; D006801:Humans; D019272:Leukocyte Elastase; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats
D009842:Oligopeptides; D011744:Pyrimidinones; C069695:ICI 200880; C087135:2-(4-fluorophenyl)-5-((methoxycarbonyl)amino)pyrimidin-4-one-3-ethanoylvaline-trifluoromethylketone; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase