title: Long-term prognostic importance of a single pulmonary wedge pressure measurement after myocardial infarction: a ten-year follow-up study.
abstract: To assess the influence on short- and long-term survival of haemodynamic variables measured after acute myocardial infarction, a 10-year prospective follow-up study was undertaken. A total of 304 patients (259 males, 45 females) discharged from hospital after myocardial infarction and under 66 years of age were studied. Haemodynamic variables measured shortly after admittance included pulmonary wedge pressure, mixed venous oxygen saturation, blood pressure and heart rate. In the analysis, adjustments were made for differences in age, gender, clinical parameters and cardiovascular risk factors. Pulmonary wedge pressure was found to be a strong and independent predictor of both short-term and long-term survival. A gradual increase of the 10-year mortality risk with elevated wedge pressure could be demonstrated (relative risk, 1.09/mmHg; 95% confidence interval, 1.04-1.15). Relative risks of patients in the three highest categories of wedge pressure, 12-15 mmHg, 15-19 mmHg and 19 mmHg and higher, compared with patients in the lowest category, lower than 12 mmHg, were 2.25 (95% CI, 1.11-4.55), 2.43 (95% CI, 1.20-4.92) and 2.57 (95% CI, 1.04-6.37), respectively. The other measured haemodynamic variables were found to be associated with short-term mortality only. In conclusion, haemodynamic measurements after myocardial infarction are of prognostic importance after discharge. A single measurement of an elevated wedge pressure in particular unfavourably influenced both short-term and long-term survival.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: Ottervanger
authors.forename: H A
authors.initials: HA
authors.lastname: Kruijssen
authors.forename: A W
authors.initials: AW
authors.lastname: Hoes
authors.forename: A
authors.initials: A
authors.lastname: Hofman
mesh_terms: D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology; D015996:Survival Rate
chemical_list: D002784:Cholesterol; D010100:Oxygen