Feedback inhibition of cholecystokinin secretion by bile acids and pancreatic proteases.
Feedback inhibition of CCK release by bile acids and pancreatic proteases is well established in the rat. The question of whether these mechanisms are important in humans has not been completely resolved, but current evidence strongly suggests that feedback regulation of CCK release by bile acids is present in humans and is physiologically significant, whereas the existence and importance of feedback regulation of CCK release by pancreatic proteases in humans are still highly controversial.
Green
G M
GM
Department of Physiology, University of Texas Health Science Center at San Antonio 78284.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology / Q000502:physiology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004063:Digestion / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000502:physiology*; D010450:Endopeptidases / Q000378:metabolism*; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology; D006801:Humans; D010179:Pancreas / Q000201:enzymology*; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D001647:Bile Acids and Salts; D002766:Cholecystokinin; D010450:Endopeptidases