Natural resistance of opossum (Didelphis marsupialis) to the mapanare (Bothrops lanceolatus) snake venom.
The inactivation of local and general effects of the Mapanare (Bothrops lanceolatus) venom by Opossum's (Didelphis marsupialis) serum fractions was tested using an in vivo assay and an in vitro preincubation experiment. A serum fraction of the Opossum serum has been obtained by immunochemical purification. It is only present in opossum's protective opossum serum fraction (F-0.1).
Pifano
F
F
Instituto de Medicina Tropical, Universidad Central de Venezuela.
Aguilar
I
I
Giron
M E
ME
Gamboa
N
N
Rodriguez-Acosta
A
A
D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D017837:Bothrops; D002848:Chromatography, DEAE-Cellulose / Q000379:methods; D002850:Chromatography, Gel / Q000379:methods; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced; D051379:Mice; D009893:Opossums / Q000097:blood*; D014687:Venezuela
D001798:Blood Proteins; D003435:Crotalid Venoms