title: Coating of liposomes with transferrin: physicochemical study of the transferrin-lipid system.
abstract: Transferrin was incorporated into the external surface of liposomes that were previously derivatized with ceramides. This new hydrophobic derivative of transferrin was incubated with liposomes at different protein-to-lipid ratios. The surface activity of both native and derivatized transferrin was determined with monomolecular layers as a membrane model. The maximal interaction was found with dipalmitoylphosphatidylcholine in all the experiences.
authors.affiliation: Physicochemical Unit, Faculty of Pharmacy, University of Barcelona, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Egea
authors.forename: M L
authors.initials: ML
authors.lastname: García
authors.forename: M A
authors.initials: MA
authors.lastname: Alsina
authors.forename: F
authors.initials: F
authors.lastname: Reig
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D002518:Ceramides / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007700:Kinetics; D008081:Liposomes; D008567:Membranes, Artificial; D010084:Oxidation-Reduction; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties; D013816:Thermodynamics; D014168:Transferrin / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D002518:Ceramides; D008081:Liposomes; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D012545:Schiff Bases; D014168:Transferrin; D015060:1,2-Dipalmitoylphosphatidylcholine; C007510:1,2-dipalmitoyl-3-phosphatidylethanolamine; C017251:1,2-oleoylphosphatidylcholine