The effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on feeding in the rat.
We have examined the effects of the selective 5-HT1A receptor antagonist, WAY-100135, on feeding and on 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced hyperphagia in rats. Given alone, WAY-100135 (1-10 mg/kg s.c.) did not affect the food intake of fasted or satiated rats; however, in free feeding rats, WAY-100135 (3 mg/kg s.c.) significantly attenuated 8-OH-DPAT-induced hyperphagia (0.1 mg/kg s.c.). Using a satiety sequence analysis of feeding behaviour, WAY-100135 (1 mg/kg s.c.) did not affect behaviour per se, but significantly antagonised the increased incidence of feeding, but not the decrease in observations of grooming following 8-OH-DPAT (0.1 mg/kg s.c.). These data provide the first demonstration of the antagonism, by a selective 5-HT1A receptor antagonist, of 8-OH-DPAT-induced feeding; an effect mediated via the somatodendritic 5-HT1A autoreceptor. These results also suggest that 5-HT1A receptor antagonists may have no intrinsic effect on food intake or feeding behaviour.
Hartley
J E
JE
Wyeth Research UK Ltd., Taplow, Maidenhead, Berks, UK.
Fletcher
A
A
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D006963:Hyperphagia / Q000139:chemically induced; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012702:Serotonin Antagonists
D010879:Piperazines; D012702:Serotonin Antagonists; C081293:WAY 100135; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin