title: Blood and placental lead levels in an Indian city: a preliminary report.
abstract: A preliminary investigation was carried out in a hospital in the city of Lucknow, India, to provide information on the possible range of lead (Pb) exposure in pregnant women and fetuses, to correlate high Pb levels with various socioenvironmental factors, and to examine any possible association between reproductive outcome and Pb levels in this population. The results indicate that maternal blood lead levels were higher in those who experienced abnormal deliveries and in those who ate nonvegetarian diets or drank groundwater compared with the respective control groups. Placenta, cord blood, and fetal membranes from both normal and abnormal delivery cases showed no significant differences in their Pb content. Other socioenvironmental factors did not influence these Pb levels. However, incidence of higher Pb levels in maternal blood (17% and 38% with Pb > 25 micrograms/dl in normal and abnormal deliveries, respectively) and cord blood (> 10 micrograms/dl) reflect a need for regular monitoring and lowering of environmental Pb exposure.
authors.affiliation: Neurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Saxena
authors.forename: C
authors.initials: C
authors.lastname: Singh
authors.forename: R C
authors.initials: RC
authors.lastname: Murthy
authors.forename: N
authors.initials: N
authors.lastname: Mathur
authors.forename: S V
authors.initials: SV
authors.lastname: Chandra
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004781:Environmental Exposure; D005321:Extraembryonic Membranes / Q000737:chemistry; D005247:Feeding Behavior; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007194:India / Q000453:epidemiology; D007854:Lead / Q000032:analysis*; D007855:Lead Poisoning / Q000097:blood* / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016014:Linear Models; D010920:Placenta / Q000737:chemistry*; D011159:Population Surveillance; D011247:Pregnancy; D011256:Pregnancy Outcome; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D014505:Urban Population; D014881:Water Supply
chemical_list: D007854:Lead