Acute hypoxemic respiratory failure following intrapleural thrombolytic therapy for hemothorax.
Intrapleural instillation of thrombolytic agents has been useful in the treatment of hemothorax when thoracostomy tube drainage is unsuccessful. We present a patient who developed acute hypoxemic respiratory failure following the intrapleural instillation of both streptokinase and urokinase 24 h apart. Hypoxemia most likely resulted from a direct effect of the products of fibrinolysis on the pulmonary circulation.
Frye
M D
MD
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston.
Jarratt
M
M
Sahn
S A
SA
D000208:Acute Disease; D006491:Hemothorax / Q000188:drug therapy*; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced*; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D010994:Pleura; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D013300:Streptokinase / Q000008:administration & dosage / Q000009:adverse effects; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects
D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator