[Ultrastructural findings in piecemeal necrosis in mildly active chronic hepatitis].
Ultrastructural and immunohistochemical investigation of hepatic tissue samples from 10 patients with mildly active chronic hepatitis (3 of them type B) showed round cell infiltration with prevailing T lymphocytes, sparse macrophages and solitary plasmacytes in marginal sections of piecemeal necroses. Hepatocytes were destroyed by apoptosis and relatively quickly enguefed into macrophages. A lytic destruction or a bigger admixture of polymorphs were not proved. Later, a withdrawal of lymphocytic infiltration and disappearance of plasmacytes occurred. Pseudoductuli spread into piecemeal necroses along capillarized sinusoids and granulation tissue grew from portobiliary fields. A sort of fibroblasts and myofibroblasts occurred during healing. Some of them comprising small lipidic vacuoles may have represented transformed perisinusoidal (Ito) cells.
Chlumská
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II. patologicko-anatomický ústav 1. LF. UK, Praha.
D000293:Adolescent; D000328:Adult; D005260:Female; D006521:Hepatitis, Chronic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009336:Necrosis
Ultrastrukturální nálezy v piecemeal nekrózách u mírnĕ aktivní chronické hepatitidy.