[Cytogenetic study in disorders of human reproduction].
We reviewed 1347 cytogenetic studies performed in a period of eight years to analyze chromosomal translocations and their relation with reproductive failure. Twenty nine index cases were detected representing a global incidence of 2.2% thirteen (45%) were balanced reciprocal translocations between autosomes, thirteen (45%) were robertsonian translocations and three (10%) were X; autosomal translocations. The most frequent indication for the study were, for each group, respectively, recurrent abortion, a child with congenital malformations and ovarian dysfunction. Our results are compared with those of other authors and the mechanisms and figure risks for unbalanced offspring are discussed.
Orozco Quiyono
M
M
Departamento de Genética, Instituto Nacional de Perinatología, S.S. México, D.F.
Grether
P
P
Zavaleta
M J
MJ
Manzanero
J
J
D000015:Abnormalities, Multiple / Q000235:genetics*; D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000453:epidemiology* / Q000235:genetics; D025063:Chromosome Disorders; D002877:Chromosomes, Human / Q000648:ultrastructure; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007247:Infertility, Female / Q000235:genetics*; D008297:Male; D011247:Pregnancy
Estudio citogenético en los trastornos de la reproducción humana.