title: Host cell proteases controlling virus pathogenicity.
abstract: The majority of viral glycoproteins that undergo post-translational proteolysis are cleaved by ubiquitous intracellular proteases; however, a minority are cleaved by secreted proteases available only in a few host systems. The interplay of viral glycoproteins and cellular proteases may have a pivotal role in the spread of infection, host range and pathogenicity.
authors.affiliation: Institut für Virologie, Philipps-Universität Marburg, Germany.
authors.forename: H D
authors.initials: HD
authors.lastname: Klenk
authors.forename: W
authors.initials: W
authors.lastname: Garten
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D016384:Consensus Sequence; D010450:Endopeptidases / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014777:Virus Diseases / Q000378:metabolism / Q000382:microbiology; D014780:Viruses / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D006023:Glycoproteins; D014764:Viral Proteins; D010450:Endopeptidases