HLA-A, B, C and DR in hepatitis B virus (HBV)-related liver cirrhosis: a study of 851 elderly subjects.
The possible correlation between HLA system and liver cirrhosis secondary to HBV infection has been studied in 102 hospitalized elderly patients affected by liver cirrhosis (histologically proven) and 749 elderly health controls. Increased frequencies of HLA-A2, Cw4, Cw5, DR4, DR5 and DR7 have been observed in patients with liver cirrhosis and previous HBV infection, while a lower frequency of HLA-A2 and higher frequencies of HLA-A3, B35, Cw4, DR3 have been observed in patients without previous HBV infection when compared with controls.
Ricci
G
G
III Geriatric Division, Ospedale Multizonale S Gerardo dei Tintori, Monza, Milan.
Ghiazza
B
B
Bombelli
G
G
Russo
E
E
Illeni
M T
MT
D000368:Aged; D006684:HLA-DR Antigens / Q000032:analysis*; D006509:Hepatitis B / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D008103:Liver Cirrhosis / Q000276:immunology*
D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I