title: [Potential for using kappa-carrageenan for characterization of cell functional status in the system of mononuclear phagocytes in cytostatic disease].
abstract: Intraperitoneal administration of doxorubicin in the maximum tolerable dose of 6 mg/kg to CBA mice reduces the release of colloidal charcoal from the blood bed, lowers the levels of peritoneal macrophages, results in monocytopenia and a short-term moderate inhibition of monocytopoiesis. kappa-Carrageenan given in an intraperitoneal dose of 5 mg/kg 24 hours after the antitumor antibiotic leads to cell accumulation in the system of mononuclear phagocytes in the abdomen wherein they phagocytes carrageenan, to stimulation of monocytopoiesis. Intraperitoneal polygalactan causes a long-term (25-day) cell block in the mononuclear phagocyte system primarily in the abdomen, as well as in the liver, bone marrow, and spleen, reducing, to a greater extent, the clearing activity of mononuclear phagocytes in mice pretreated with the cytostatic.
authors.forename: G V
authors.initials: GV
authors.lastname: Karpova
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D002351:Carrageenan; D004317:Doxorubicin / Q000009:adverse effects*; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D010586:Phagocytes / Q000187:drug effects*
chemical_list: D004317:Doxorubicin; D002351:Carrageenan
vernacular_title: O vozmozhnosti ispol'zovaniia karaginana kappa dlia kharakteristiki funktsional'nogo sostoianiia kletok sistemy mononuklearnykh fagotsitov pri tsitostaticheskoĭ bolezni.