Preventing otitis media.
Recurrent acute otitis media (AOM) is an extremely prevalent disease in young children. Epidemiologic associations suggest that primary prevention or reduction of AOM frequency may be achieved with breast-feeding during infancy, elimination of household tobacco smoking, and use of small rather than large day-care arrangements for infants and toddlers. Secondary antimicrobial prophylaxis with amoxicillin or sulfisoxazole reduces the frequency of recurrent AOM by about 50%, but it does not appear to reduce the duration of otitis media with effusion (OME). Tympanostomy tube insertion is not as effective as amoxicillin in reducing AOM frequency in children without OME. Adenoidectomy appears to be warranted for children who develop recurrent AOM after extrusion of tubes. Vaccines against the common bacteria and viruses causing AOM hold the greatest promise of preventing AOM and blocking the sequence of pathologic events leading to chronic OME and middle ear sequelae. The greatest progress has been made recently with pneumococcal protein conjugate vaccines, and clinical testing is in progress.
Giebink
G S
GS
Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis.
D000208:Acute Disease; D000233:Adenoidectomy; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D006193:Haemophilus influenzae / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D001936:Moraxella catarrhalis / Q000276:immunology; D010033:Otitis Media / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D010034:Otitis Media with Effusion / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination
D000900:Anti-Bacterial Agents