title: Positive cervical smear with subsequent normal colposcopy and histology--frequency of CIN in a long-term follow-up.
abstract: From a total of 1466 new cases of cervical smears suggesting cervical intraepithelial neoplasia (CIN) II or worse, all examined with colposcopy and biopsies, 328 cases (22.4%) were initially examined with vaginal and cervical colposcopy, directed biopsies of portio, and endocervical curettage (ECC) with normal results. Patients were followed-up with regular colposcopy and cervical smear for an average of 10.6 years (2-19 years). In 72 cases (22%) a CIN occurred, in general more than 1 year (mean 2.96 years) after entering the study. Possible explanations are discussed and careful monitoring of this group of patients is recommended.
authors.affiliation: Department of Obstetrics and Gynecology, Falu Hospital, Falun, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Hellberg
authors.forename: S
authors.initials: S
authors.lastname: Nilsson
authors.forename: J
authors.initials: J
authors.lastname: Valentin
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D003127:Colposcopy; D004107:Dilatation and Curettage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015993:Life Tables; D008875:Middle Aged; D011237:Predictive Value of Tests; D013997:Time Factors; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014626:Vaginal Smears