[The kinetic characteristics and stoichiometry of corticosterone interaction with cytosol receptors].
The interaction of molybdate-stabilised cytosol receptor of the rat brain and liver with corticosterone was studied in conditions of equilibrium and non-equilibrium in vitro. The hormone-receptors complexes with varying number of the receptor molecules were found to form consequentially. During their formation the complexes revealed the properties of disperse phases. The concentration of the receptors seems to be one of the regulating factors of activity of the complexes. An original experimental technique is described.
Efimov
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D000818:Animals; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000737:chemistry / Q000493:pharmacokinetics*; D003600:Cytosol / Q000378:metabolism*; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011987:Receptors, Steroid / Q000378:metabolism*; D013696:Temperature; D013997:Time Factors
D011987:Receptors, Steroid; C024357:corticosterone receptor; D003345:Corticosterone
Kinetichskaia kharakteristika i stekhiometriia vzaimodeĭstviia kortikosterona s tsitozol'nymi retseptorami.