title: Polyarthritis resembling juvenile rheumatoid arthritis in a girl with chronic granulomatous disease.
abstract: Chronic granulomatous disease (CGD) is an uncommon disorder affecting neutrophil function, and is characterized by recurrent and severe pyogenic infections. Associated autoimmune disorders, in particular lupus-like disorders, are found in carriers of X-linked CGD and in patients with both the X-linked and the autosomal recessive (AR) forms of the disease. We describe a girl with the AR form of CGD and with rheumatoid factor-positive polyarthritis resembling juvenile rheumatoid arthritis. This association has been reported previously only in a single case report of a patient with probable CGD. The present report further substantiates the association between autoimmune phenomena and CGD.
authors.affiliation: Department of Paediatrics, National University of Singapore, Kent Ridge.
authors.forename: B W
authors.initials: BW
authors.lastname: Lee
authors.forename: H K
authors.initials: HK
authors.lastname: Yap
mesh_terms: D001168:Arthritis / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D001171:Arthritis, Juvenile / Q000175:diagnosis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D012217:Rheumatoid Factor