title: Comparison of a three-component acellular pertussis vaccine with whole cell pertussis vaccine in two-month-old children.
abstract: An acellular pertussis vaccine (DTaP) containing pertussis toxoid, filamentous hemagglutinin and the 69-kDa outer membrane protein (pertactin) was compared with United States-licensed whole cell pertussis vaccine (DTwP) as a three dose sequence at 2, 4 and 6 months of age. Eighty infants were enrolled; 62 received DTaP and 18 received DTwP. Sixty-two infants had preimmunization and 1 month postimmunization sera available for pertussis antibodies. No infant experienced a serious adverse reaction. Significantly fewer infants in the DTaP group experienced irritability (P < 0.001) and moderate to severe injection site pain and redness (P < 0.001, and P = 0.03, respectively). The DTaP group also had significantly greater increases in geometric mean titers of antibodies against filamentous hemagglutinin (P < 0.001) and pertactin (P = 0.006). This three-component DTaP vaccine induced an antibody response to pertussis toxin, filamentous hemagglutinin and pertactin but caused fewer adverse reactions than DTwP when administered as a primary series of immunization to 2-month-old infants.
authors.affiliation: Elmwood Pediatric Group, University of Rochester Medical Center, NY 14642.
authors.forename: M E
authors.initials: ME
authors.lastname: Pichichero
authors.forename: J L
authors.initials: JL
authors.lastname: Green
authors.forename: A B
authors.initials: AB
authors.lastname: Francis
authors.forename: S M
authors.initials: SM
authors.lastname: Marsocci
authors.forename: A M
authors.initials: AM
authors.lastname: Lynd
authors.forename: T
authors.initials: T
authors.lastname: Litteer
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001425:Bacterial Outer Membrane Proteins / Q000008:administration & dosage / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D006388:Hemagglutinins / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008297:Male; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D014121:Toxoids / Q000008:administration & dosage / Q000276:immunology*; D010566:Virulence Factors, Bordetella
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D014121:Toxoids; D010566:Virulence Factors, Bordetella; C051093:pertussis toxoid; C068929:pertactin