[The mechanisms of the effect of furosemide on the water permeability of the frog bladder and on oxytocin-stimulated contractions of the rat uterus].
Furosemide increased the hydrosmotic water flow in the frog urinary bladder and promoted the ADH-like effect of inhibitors of phosphodiesterase cAMP, potentiated hydrosmotic effects of theophylline and serosal osmotic hypertonicity but failed to change the effect of pituitrin. Fur reversibly suppressed oxytocin-induced contractions in the rat myometrium, inhibited the activity of the frog urinary bladder PDE cAMP, whereas the activity of the enzyme from the rat medulla and myometrium was activated by saluretic. Incubation of the myometrium strips in Fur resulted in a decrease in the cAMP content of the tissue. The cAMP seems to play an important role both in the myometrium smooth muscle relaxation and in the oxytocin-activated contractions.
Bagrov
Ia Iu
IaIu
Manusova
N B
NB
Mozhaeva
M G
MG
Ostretsova
I B
IB
Antipenko
A E
AE
Diatlov
R V
RV
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000187:drug effects; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009995:Osmosis / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology*; D011896:Rana temporaria; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000187:drug effects* / Q000201:enzymology; D014590:Uterine Contraction / Q000187:drug effects*; D014867:Water / Q000378:metabolism*
D014867:Water; D010121:Oxytocin; D005665:Furosemide; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Mekhanizmy vliianiia furosemida na vodnuiu pronitsaemost' mochevogo puzyria liagushki i stimulirovannye oksitotsinom sokrashcheniia matki krysy.