[Changes in the intensity of cell proliferation and spontaneous death in the primary focus and metastases in animals with Lewis' tumor. The effect of the surgical removal of the tumor].
Changes in proliferation and spontaneous death of the tumor death have been studied during the Lewis carcinoma growth and dissemination after the primary tumor surgery. The slowed down rate of the primary tumour growth was shown to be due to spontaneous death of cells. Lung metastases are characterized by a high proliferative activity of tumour cells and a low cell loss. The primary tumour surgery stimulates lung metastases via enhanced proliferation of the tumor cells with apoptosis preserved at the same level.
Potapov
Iu N
IuN
Krutova
T V
TV
Khaleev
D V
DV
Pashkova
V S
VS
D000818:Animals; D017209:Apoptosis; D002277:Carcinoma / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis; D009368:Neoplasm Transplantation; D013997:Time Factors
Izmenenie intensivnosti razmnozheniia i spontannoĭ gibeli kletok v pervichnom ochage i metastazakh u zhivotnykh s opukhol'iu L'iuis. Vliianie operativnogo udaleniia opukholi.