Effects of low-level lead on retinal ganglion sustained and transient cells in developing rats.
Neonatal rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solutions. The alterations in the excitability and temporal response properties of retinal ganglion cells in adult rats (90 days) following developmental lead exposure were studied. The results of this investigation demonstrated that the lead exposure in neonatal rats caused an increase in excitability, and a decrease in optimal temporal frequency, bandwidth at half amplitude, temporal resolution, and response phase of the retinal ganglion cells in adult rats. Compared with the sustained cells, the transient cells had a much greater alteration in excitability and temporal response properties.
Ruan
D Y
DY
Department of Biology, University of Science and Technology of China, Anhui, People's Republic of China.
Tang
L X
LX
Zhao
C
C
Guo
Y J
YJ
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D004594:Electrophysiology; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology; D005260:Female; D007854:Lead / Q000633:toxicity*; D008839:Microelectrodes; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000502:physiology
D007854:Lead