title: The influence of age on the development of two-kidney, one-clip hypertension in the rat.
abstract: The role of age in the development of two-kidney, one-clip (2K1C) renal hypertension was evaluated. Blood pressure response to aortic constriction was more pronounced in young rats although the alterations of renal renin activity and body fluid volumes were greater in adult ones. Obtained results suggested that 2K1C renal hypertension is maintained by reciprocal interaction of renin-angiotensin system and body fluid volume alterations only in adult rats. In young rats other factors might be more important.
authors.affiliation: Institute of Physiology, Czech Academy of Sciences, Prague.
authors.forename: J
authors.initials: J
authors.lastname: Kunes
mesh_terms: D000367:Age Factors; D000818:Animals; D001834:Body Water / Q000502:physiology; D004195:Disease Models, Animal; D006977:Hypertension, Renal / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology