Irreversible cardiomyopathy due to thyrotoxicosis.
We report 4 adult patients with thyrotoxicosis accompanied by irreversible low-output heart failure. Each patient showed elevated plasma levels of thyroid hormone and prolonged low-output heart failure even after thyroid function returned to normal. Specimens of the right ventricular myocardium stained with anti-beta myosin heavy-chain MAb showed a normal staining pattern with a predominance of the beta-form. Our observations suggest that thyrotoxicosis may be one possible cause of irreversible cardiomyopathy.
Ebisawa
K
K
Department of Cardiology, Jichi Medical School, Tochigi, Japan.
Ikeda
U
U
Murata
M
M
Sekiguchi
H
H
Nagai
R
R
Yazaki
Y
Y
Shimada
K
K
D000368:Aged; D002303:Cardiac Output, Low / Q000209:etiology* / Q000473:pathology; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013971:Thyrotoxicosis / Q000150:complications*