Differences in HLA-DR association with rheumatoid arthritis among migrant Indian communities in South Africa.
Previous surveys among Indians with RA have shown a significant association with HLA DR4 in North India and with HLA DR1 in the UK. We studied a migrant Indian population in South Africa to determine their genetic associations with RA. A group of 121 unrelated RA patients from three communities (Hindi, Muslims and Tamils) were studied. The Muslims showed a significant association with DR4 but the Hindi and Tamils showed a significant association with DR10. This survey shows that the Indian community is a heterogenous group regarding their HLA associations with RA and different associations are noted in the various communities.
Mody
G M
GM
Department of Medicine, University of Natal, Durban, South Africa.
Hammond
M G
MG
D000328:Adult; D000595:Amino Acid Sequence; D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D013019:South Africa / Q000453:epidemiology; D014171:Transients and Migrants; D006113:United Kingdom / Q000453:epidemiology
D006684:HLA-DR Antigens