Acute renal failure after intravenous immunoglobulin therapy.
We describe 3 patients given intravenous immunoglobulin (IVIG) who developed acute renal failure temporally related to IVIG therapy. The rise in BUN and creatinine appeared to be transient and reversible 8-14 days after discontinuation of the drug. Renal dysfunction was mild in 2 patients but was severe in one who presented with azotemia, worsening congestive heart failure, severe hyponatremia, hyperkalemia, and metabolic acidosis necessitating hemodialysis. Renal dysfunction was not associated with a specific immunoglobulin preparation or dose.
Pasatiempo
A M
AM
Department of Medicine, Medical College Hospital, Philadelphia, PA 19129.
Kroser
J A
JA
Rudnick
M
M
Hoffman
B I
BI
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology*; D000368:Aged; D001806:Blood Urea Nitrogen; D003240:Connective Tissue Diseases / Q000628:therapy; D003404:Creatinine / Q000097:blood; D005260:Female; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D008875:Middle Aged; D013997:Time Factors
D016756:Immunoglobulins, Intravenous; D003404:Creatinine