title: Cerebrospinal fluid production during proximal aortic cross-clamping.
abstract: During cross-clamping (XC) of the thoracic aorta, the cerebrospinal fluid pressure (CSFP) increases. The mechanism of the increased CSFP is unknown but increased cerebrospinal fluid (CSF) production has been suggested as one explanation. The aim of this study was to investigate whether the CSF production rate was influenced by proximal XC of the thoracic aorta in an experimental model. Using the ventriculocisternal perfusion method including [14C] inulin, the rate of CSF production was measured before, during and after XC of the thoracic aorta in seven pigs. The CSFP was measured via a catheter in the lateral ventricle and the thoracic aorta was cross-clamped just distal to the left subclavian artery for 30 minutes. Following cross-clamping the CSFP increased from 5 mmHg to 11 mmHg (p < 0.001) and remained elevated during XC. In contrast the CSF production rate was 0.09 ml/min prior to XC and was not significantly altered following XC. In conclusion this experimental study indicates that increased CSF production is not responsible for the increase in CSFP during XC.
authors.affiliation: Department of Surgery, University Hospital of Trondheim, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Strømholm
authors.forename: O D
authors.initials: OD
authors.lastname: Saether
authors.forename: P
authors.initials: P
authors.lastname: Aadahl
authors.forename: G
authors.initials: G
authors.lastname: Unsgård
authors.forename: H O
authors.initials: HO
authors.lastname: Myhre
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D003250:Constriction; D005260:Female; D008297:Male; D013552:Swine; D013997:Time Factors