title: Glial and neuronoglial malformative lesions associated with medically intractable epilepsy.
abstract: In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical dysplasia" in 6 patients and to "microdysgenesis" in 5 others. This study focuses on the various neuropathological presentations of these malformative epileptogenic lesions, and on correlations with neuro-imaging data.
authors.affiliation: Department of Neurology, Bordeaux II University, France.
authors.forename: A
authors.initials: A
authors.lastname: Vital
authors.forename: C
authors.initials: C
authors.lastname: Marchal
authors.forename: H
authors.initials: H
authors.lastname: Loiseau
authors.forename: A
authors.initials: A
authors.lastname: Rougier
authors.forename: J M
authors.initials: JM
authors.lastname: Pedespan
authors.forename: J
authors.initials: J
authors.lastname: Rivel
authors.forename: C
authors.initials: C
authors.lastname: Vital
mesh_terms: D000293:Adolescent; D000328:Adult; D001253:Astrocytes / Q000648:ultrastructure; D001921:Brain / Q000002:abnormalities; D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology; D002648:Child; D004827:Epilepsy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006222:Hamartoma / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure*