A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22.
The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.
Vetrie
D
D
Paediatric Research Unit, United Medical School, London, United Kingdom.
Kendall
E
E
Coffey
A
A
Hassock
S
S
Collins
J
J
Todd
C
C
Lehrach
H
H
Bobrow
M
M
Bentley
D R
DR
Harris
A
A
D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics; D016386:Chromosome Walking; D018244:Chromosomes, Artificial, Yeast; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000235:genetics; D000795:Fabry Disease / Q000235:genetics; D015723:Gene Library; D005819:Genetic Markers; D006801:Humans; D014960:X Chromosome
D005819:Genetic Markers