title: The effects of prostaglandin E2 injected into the paraventricular nucleus of the hypothalamus on brown adipose tissue thermogenesis in spontaneously hypertensive rats.
abstract: We examined brown adipose tissue (BAT) thermogenic responses to prostaglandin E2 (PGE2) injected into the paraventricular nucleus of the hypothalamus in the spontaneously hypertensive rat (SHR). 250 ng of PGE2 produced smaller increases in BAT and core temperatures in SHRs compared to their normotensive controls, the WKYs. The results of the present study suggest that the ability of SHRs to mount a febrile response may be compromised.
authors.affiliation: Douglas Hospital Research Center, Department of Neurology, McGill University, Montreal, Que., Canada.
authors.forename: S
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: M J
authors.initials: MJ
authors.lastname: Meaney
authors.forename: S
authors.initials: S
authors.lastname: Amir
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011921:Rats, Inbred WKY / Q000502:physiology
chemical_list: D015232:Dinoprostone