Changes in plasma tetrahydrobiopterin levels of depressives in depressive and remission phases: reconfirmed by measurement with an internal standard.
Plasma total biopterin and tetrahydrobiopterin levels of 10 normal controls and 10 patients with monopolar depression were measured with and without internal standard. The levels did not differ between the two methods. A significant increase of total biopterin levels and the lower ratio of tetrahydrobiopterin to total biopterin in the depressive phase were observed in the plasma of patients with depression compared to normal controls, and these changes in plasma biopterin tended to normalize in the remission phase.
Hashimoto
R
R
Department of Neuropsychiatry, Aichi Medical College, Japan.
Mizutani
M
M
Ohta
T
T
Nakazawa
K
K
Nagatsu
T
T
D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003866:Depressive Disorder / Q000097:blood* / Q000523:psychology; D006801:Humans; D011569:Psychiatric Status Rating Scales; D012015:Reference Standards
D001708:Biopterins; C003402:sapropterin