title: Preoperative chemotherapy in the management of intracaval extension of Wilms' tumor.
abstract: Extension of Wilms' tumor into the renal vein and vena cava complicates the operative treatment of a small but significant number of patients. Two children presented with Wilms' tumor and intracaval tumor extension. After biopsy, both children were given chemotherapy. In one case the tumor completely disappeared from the vena cava, and in the other the tumor regressed substantially, and proximal control became possible at the level of the infrahepatic vena cava. Both children then had an uneventful nephrectomy that was greatly simplified. We conclude that preoperative chemotherapy can induce resolution of intravascular tumor, and may be a useful option in cases of extension of Wilms' tumor into the vena cava.
authors.affiliation: Department of Pediatric Surgery, Tufts University School of Medicine, Boston Floating Hospital, MA 02111.
authors.forename: T M
authors.initials: TM
authors.lastname: Crombleholme
authors.forename: N N
authors.initials: NN
authors.lastname: Jacir
authors.forename: C G
authors.initials: CG
authors.lastname: Rosenfield
authors.forename: S
authors.initials: S
authors.lastname: Lew
authors.forename: B H
authors.initials: BH
authors.lastname: Harris
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D009361:Neoplasm Invasiveness; D011292:Premedication; D014682:Vena Cava, Inferior; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin