title: Antifungal agents. 7. Dichlorophenylpyrrylimidazolylmethane derivatives: synthesis and antifungal activities.
abstract: The synthesis and antifungal activities of some dichlorophenyl-1H-pyrrol-2-yl-1H-imidazol-1-ylmethane derivatives substituted at pyrrole nitrogen are reported. When tested against Candida albicans and Candida spp., some derivatives were found to be from two to four times less active than miconazole, bifonazole and ketoconazole, used as standard controls.
authors.affiliation: Dipartimento di studi farmaceutici, Università di Roma La Sapienza, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Massa
authors.forename: A
authors.initials: A
authors.lastname: Mai
authors.forename: R
authors.initials: R
authors.lastname: Ragno
authors.forename: G C
authors.initials: GC
authors.lastname: Porretta
authors.forename: A
authors.initials: A
authors.lastname: Retico
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
authors.forename: M
authors.initials: M
authors.lastname: Artico
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D011758:Pyrroles