title: Reduced sensitivity of tuberculosis serodiagnosis in patients with AIDS in Uganda.
abstract: METHODS
  The diagnostic utility of serodiagnosis of tuberculosis in HIV-infected persons was studied in Kampala, Uganda.
  
  
  OBJECTIVE
  This study was undertaken to evaluate the utility of a recently described serologic assay for the diagnosis of tuberculosis in HIV-infected patients.
  
  
  METHODS
  The study was undertaken as a cross-sectional survey of 349 subjects, including human immunodeficiency virus-infected and uninfected patients with tuberculosis and control subjects. Serum from each subject was assayed by enzyme-linked immunosorbent assay (ELISA) for IgG antibody to the 30,000 dalton antigen of Mycobacterium tuberculosis.
  
  
  RESULTS
  Test sensitivity dropped from 0.62 in non HIV-infected tuberculous patients to 0.28 in HIV-infected patients.
  
  
  CONCLUSIONS
  ELISA serodiagnosis of tuberculosis may have a markedly decreased utility in populations where HIV infection is prevalent.
authors.affiliation: Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4978.
authors.forename: T M
authors.initials: TM
authors.lastname: Daniel
authors.forename: A A
authors.initials: AA
authors.lastname: Sippola
authors.forename: A
authors.initials: A
authors.lastname: Okwera
authors.forename: S
authors.initials: S
authors.lastname: Kabengera
authors.forename: E
authors.initials: E
authors.lastname: Hatanga
authors.forename: T
authors.initials: T
authors.lastname: Aisu
authors.forename: S
authors.initials: S
authors.lastname: Nyole
authors.forename: F
authors.initials: F
authors.lastname: Byekwaso
authors.forename: M
authors.initials: M
authors.lastname: Vjecha
authors.forename: L E
authors.initials: LE
authors.lastname: Ferguson
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000907:Antibodies, Bacterial / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014376:Tuberculosis / Q000175:diagnosis*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G