Cortical development and topographic maps: patterns of cell dispersion in developing cerebral cortex.
Cortical neurons are organized into highly patterned ensembles of cells, each with a distinct physiological function. The precursors of these cells arise in the ventricular zone, itself a highly patterned mosaic of cells. To determine whether the ventricular pattern presages the adult, investigators examine the process of cell migration. Recent evidence suggests that both radial (pattern-preserving) and tangential (pattern-blurring) cell movements occur during development.
Herrup
K
K
Alzheimer Research Lab, Case Western Reserve Medical School, Cleveland, Ohio 44106.
Silver
J
J
D000818:Animals; D000831:Animals, Newborn; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology