title: Effects of pimobendan on isolated human right atria strips and on isolated left atria of the rat.
abstract: The present study describes the effects of pimobendan on isolated human right atrial strips and on isolated left atria of the rat. Pimobendan induces a positive inotropic effect both in human and rat preparations. The maximal increase (28 +/- 2.0%) obtained with pimobendan in the strips from human right atria was similar to that obtained in left atria of the rat (31 +/- 1.8%). These observations may have some clinical relevance as pimobendan might prove to be an alternative to catecholamines for inotropic support in patients who undergo general anaesthesia.
authors.affiliation: Department of Physiology and Pharmacology, School of Medicine, CSV Arrixaca Hospital, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Llobell
authors.forename: R
authors.initials: R
authors.lastname: Dávalos
authors.forename: M L
authors.initials: ML
authors.lastname: Laorden
mesh_terms: D000818:Animals; D016279:Atrial Function, Left / Q000187:drug effects*; D016280:Atrial Function, Right / Q000187:drug effects*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D046508:Culture Techniques; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006325:Heart Atria / Q000187:drug effects; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011724:Pyridazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002316:Cardiotonic Agents; D011724:Pyridazines; C041648:pimobendan; D004121:Dimethyl Sulfoxide