Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study.
Hypertrophic scars and Dupuytren's disease are characterized by the presence of modified fibroblasts or myofibroblasts which are allegedly responsible for tissue retraction and excessive connective tissue production. gamma-Interferon, a cytokine produced by T-helper lymphocytes, has been shown to decrease fibroblast replication, alpha-smooth-muscle actin (the actin isoform characterizing myofibroblasts) expression, and collagen production. We have investigated in an open pilot study the possibility that intralesional injections of gamma-interferon exert a beneficial effect on the evolution of hypertrophic scars and Dupuytren's disease. In the 14 selected patients, gamma-interferon decreased the symptoms and the size of the lesions of both diseases; in hypertrophic scars, immunofluorescence examination showed that alpha-smooth-muscle actin expression also was decreased in myofibroblasts. Moreover, in fibroblasts cultured from 4 patients with hypertrophic scars, gamma-interferon decreased replication and alpha-smooth-muscle actin expression in vitro. Our results suggest that gamma-interferon could represent a useful adjunct to the nonsurgical therapy of hypertrophic scars and Dupuytren's disease. Larger controlled clinical studies, however, should test the validity of these preliminary observations.
Pittet
B
B
Department of Surgery, University Hospital of Geneva, Switzerland.
Rubbia-Brandt
L
L
Desmoulière
A
A
Sappino
A P
AP
Roggero
P
P
Guerret
S
S
Grimaud
J A
JA
Lacher
R
R
Montandon
D
D
Gabbiani
G
G
D000199:Actins / Q000032:analysis; D000328:Adult; D002478:Cells, Cultured; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000473:pathology; D004387:Dupuytren Contracture / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D005350:Fibroma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D015552:Injections, Intralesional; D007371:Interferon-gamma / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009130:Muscle, Smooth / Q000737:chemistry; D009218:Myosins / Q000032:analysis; D010865:Pilot Projects; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000199:Actins; D007371:Interferon-gamma; D009218:Myosins