title: [Pharmacokinetic and clinical studies on fluconazole in the pediatric field].
abstract: Pharmacokinetic, bacteriological and clinical studies on intravenous fluconazole (FLCZ) in deep seated mycoses were performed involving 4 pediatric patients. Clinical and bacteriological assessments were made on 4 patients; clinical improvements were good in 3 patients and bacteriological efficacies were rated as "eradicated" in 3 patients. No side effects nor abnormal laboratory values were observed. The pharmacokinetics were investigated in 2 patients. Good serum FLCZ concentrations were obtained at an intravenous dose of 3-6 mg/kg daily. These results indicate that FLCZ is a useful drug in the treatment of pediatric patients with systemic deep-seated mycosis.
authors.affiliation: Department of Pediatrics, General Ota Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Akita
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Sunakawa
mesh_terms: D000293:Adolescent; D002177:Candidiasis / Q000188:drug therapy*; D015725:Fluconazole / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D015725:Fluconazole