Immunoglobulin levels and cellular immune function in lead exposed workers.
The immunological status of lead acid battery workers with blood lead levels and urinary delta-aminolevulinic acid (ALA-U) concentrations ranging from safe to toxic levels has been examined and compared with those of non-exposed, age and sex matched controls. No differences in the serum concentrations of IgG, IgA and IgM between the populations were observed and there existed no correlation between blood lead level or ALA-U concentrations and serum immunoglobulin levels. In addition assessment was made of the capacity of peripheral blood mononuclear cells to respond to the mitogen phytohaemagglutinin (PHA), a correlate of T cell function. As before, there was no difference between exposed and control populations and no correlation between reactivity and blood lead concentration. Our data suggest that chronic exposure to lead fail to compromise lymphocyte function in man.
Queiroz
M L
ML
Department of Pharmacology, University of Campinas, Faculty of Medical Sciences, Brazil.
Perlingeiro
R C
RC
Bincoletto
C
C
Almeida
M
M
Cardoso
M P
MP
Dantas
D C
DC
D000622:Aminolevulinic Acid / Q000652:urine; D000917:Antibody Formation / Q000187:drug effects*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007136:Immunoglobulins / Q000097:blood; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D007855:Lead Poisoning / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D016273:Occupational Exposure
D007136:Immunoglobulins; D007854:Lead; D000622:Aminolevulinic Acid