title: Myocardial collagen and its functional role.
abstract: Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in a stiffer myocardium and ventricular diastolic dysfunction.
authors.affiliation: Dalton Research Center, University of Missouri, Columbia 65212.
authors.forename: J S
authors.initials: JS
authors.lastname: Janicki
authors.forename: B B
authors.initials: BB
authors.lastname: Matsubara
authors.forename: A
authors.initials: A
authors.lastname: Kabour
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen / Q000378:metabolism*; D004719:Endomyocardial Fibrosis / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D016276:Ventricular Function / Q000502:physiology*
chemical_list: D003094:Collagen