Paternal pericentric inversion of chromosome 4 as a cause of recurrent pregnancy loss.
A paternal pericentric inversion of chromosome 4 was ascertained through karyotype analysis of an abortus specimen proven to be 46,XX,rec(4),dup q, inv (4)(p13q28). The relationship of paternal pericentric inversion to pregnancy loss is discussed, and a recommendation for karyotype analysis of recurrent abortion specimens is made.
Wolf
G C
GC
Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, Albuquerque 87131.
Mao
J
J
Izquierdo
L
L
Joffe
G
G
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D007446:Chromosome Inversion; D002894:Chromosomes, Human, Pair 4; D005220:Fathers; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008957:Models, Genetic; D011247:Pregnancy