[Computerized hepatocyte karyometry in chronic persistent hepatitis, chronic active hepatitis, and hepatic cirrhosis].
In this study 60 cases of chronic hepatitis are analyzed: ECP n degrees 20 cases, ECA n degrees 20 cases, CE n degrees 20 cases. Besides, 10 cases of structurally normal liver. The etiology, mainly, 51.66% cases is of alcoholic nature, partly limited by hepatic virus or drugs. The nuclear polymetrismus of hepatocytes in morbidity conditions, repeats the well known note typical of this cytotype belonging to different as to morphology and functions. The median nuclear area in ECP = micron2 46,544; in ECA = micron2 50,145; in CE = micron2 54,901. In normal subjects = 35,148. The nuclear-cytoplasmatic ratio is in ECP = 0.15506; in ECA = 0.16113; in CE = 0.1602 and in normal subjects = 0.15680. Major nuclear increases are connected with alcoholic etiology with abnormal deposits of glycoproteins, of lipids and other substances in fewer quantities are referred too, with ethanolic damage of microtubules and of the Golgi apparatus.
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Unità operativa di anatomia e istologia patogica e di citogenetica, Presidio ospedaliero della USL 23 di Arezzo.
D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D048429:Cell Size; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006521:Hepatitis, Chronic / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology*; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology; D008297:Male; D008870:Microtubules / Q000648:ultrastructure; D008875:Middle Aged
Cariometria computerizzata degli epatociti nella epatite cronica persistente (ECP), nella epatite cronica attiva (ECA) e nella cirrosi epatica (CE).