[Basal and luliberin-stimulated gonadotropin secretion in ovariectomized female rats with streptozotocin-induced diabetes].
In vitro insulin effect on basal and LH-RH-stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin diabetes administered estradiol as replacing hormone therapy was studied. The results were compared to those obtained after a similar incubation of adenohypophyses of oophorectomized rats and of oophorectomized rats administered estradiol. Estradiol was found to change the type of LH-RH-stimulated gonadotropin secretion in oophorectomized animals. Basal, but not LH-RH-stimulated gonadotropin secretion, was increased in rats with experimental diabetes as against other groups. Insulin inhibited basal and increased LH-RH-stimulated gonadotropin secretion in oophorectomized rats with streptozotocin diabetes administered estradiol. A conclusion is made about impaired sensitivity of hypophyseal gonadotrophs to LH-RH in streptozotocin diabetes and about a possible contribution of insulin to regulation of body reproductive system at the level of hypophysis.
Babichev
V N
VN
Adamskaia
E I
EI
Peryshkova
T A
TA
D000818:Animals; D001481:Basal Metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006062:Gonadotropins / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol
Bazal'naia i liuliberinstimulirovannaia sekretsiia gonadotropinov u ovariéktomirovannykh samok krys so streptozototsinindutsirovannym diabetom.