[Myocardial energy metabolism in children: age-dependent myocardial utilization patterns of oxygen and energy substrates].
Myocardial utilization patterns of oxygen, lactate, pyruvate, glucose and free fatty acid (FFA) were evaluated in 65 children aged 7 months to 18 years (mean: 7.9 years) without organic cardiac lesions by coronary sinus catheterization via the femoral vein. Myocardial oxygen uptake was positively correlated with age. Myocardial oxygen uptake per unit left ventricular mass and the oxygen extraction rate were negatively correlated with age. The oxygen saturation of coronary sinus blood was significantly lower in younger children. The myocardial lactate and pyruvate extraction rates increased with age, but there was no correlation between lactate or pyruvate uptake and age. The myocardial FFA extraction rate increased with age and the FFA uptake per unit left ventricular mass was positively correlated with age. There was no significant relationship between myocardial glucose utilization and age. Coronary sinus blood flow per unit left ventricular mass was negatively correlated with age. These results indicate that younger children have significantly higher demands for coronary blood flow per unit ventricular mass, significantly higher utilization of oxygen, and significantly lower utilization of FFA, with the highest energy production rates.
Hamaoka
K
K
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine.
Onouchi
Z
Z
Itoi
T
T
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004734:Energy Metabolism / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007223:Infant; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D011773:Pyruvates / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011773:Pyruvates; D005947:Glucose