A newly identified tyrosine kinase is preferentially expressed in the gastrointestinal tract.
We have identified a novel protein tyrosine kinase, cloned from rat intestinal mRNA, which is selectively expressed at high levels in intestinal cells, but is expressed at low or insignificant levels in a variety of other epithelial and non-epithelial organs. Gastrointestinal associated kinase (GASK) mRNA is present at high levels in stomach, small intestine and colon. GASK may play an important role in the growth, differentiation and/or development of the gastrointestinal tract.
Sunitha
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Department of Pathology, Georgetown University School of Medicine, Washington, DC 20007.
Avigan
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D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D004064:Digestive System / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D012333:RNA, Messenger; C100882:gtk kinase; D011505:Protein-Tyrosine Kinases