[Two high spontaneous lung and lymph node metastasis models derived from 615 mouse pulmonary adenocarcinoma (I615PAC-8811)].
The primary donor tumor of these 2 models was a spontaneous pulmonary adenocarcinoma which was originally developed in a 23-month-old male 615 mouse in our laboratory. That mouse was sacrificed for s.c. transplantation to 2 isogeneic hosts on November 12, 1988. A total of 50 generations for diffuse type and 30 generations for nodule type have since succeeded. Nodule type: The incidence of serial s.c. transplantation of this type of tumor was 100% with a latency period of 4-7d, and the lifetime of the tumor-bearing mice was about 44d. Spontaneous metastatic rate in the lungs was 100% from the 1st to the 20th generations. Diffuse type: The incidence of the s.c. transplantation tumor was 100%. The latency period was 3-6 d and the lifetime of the tumor-bearing mice was about 22 d. The spontaneous metastatic rate in the lungs and lymph nodes (after the 7th generation) was 100% from the 1st through the 35th generations. The origin of these 2 types was the same and their morphological features were similar. But several of their biological characteristics (including drug sensitivity and s.c. transplantation tumor growth speed) were different.
Gao
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Cancer Institute, CAMS and PUMC, Beijing.
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents