title: Medical treatment of recurrent candidemia in a patient with probable Candida parapsilosis prosthetic valve endocarditis.
abstract: Fungal endocarditis is considered an absolute indication for valve replacement surgery. We describe the successful medical treatment of recurrent Candida parapsilosis candidemia with sequential treatment with amphotericin B and fluconazole in a patient with probable prosthetic valve endocarditis. Because of the presumed effectiveness of amphotericin B and fluconazole in the treatment of this patient, medical therapy should be considered as potentially useful in the treatment of recurrent C parapsilosis fungemia or endocarditis or both.
authors.affiliation: Department of Medicine and Microbiology, Veterans Affairs Medical Center, Kansas City, Mo.
authors.forename: M A
authors.initials: MA
authors.lastname: Zahid
authors.forename: S A
authors.initials: SA
authors.lastname: Klotz
authors.forename: D R
authors.initials: DR
authors.lastname: Hinthorn
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004696:Endocarditis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D015725:Fluconazole / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy* / Q000209:etiology; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D012008:Recurrence
chemical_list: D000666:Amphotericin B; D015725:Fluconazole