Selective inability of LPS-activated B lymphocytes to produce antibodies against autologous and allogeneic MHC class I antigens.
Lipopolysaccharide (LPS)-activated B lymphocytes have been found to produce autoantibodies of a variety of specificities. We found that LPS-induced autoantibodies did not include antibodies against self H-2 class I antigens, suggesting a selective tolerance induction against some, but not other, autoantigens. However, LPS-activated B lymphocytes not only failed to produce antibodies against autologous H-2 class I antigens, but also against allogeneic H-2 class I antigens, suggesting a selective regulation of B cells to synthesize antibodies directed against autologous and allogeneic major histocompatibility complex antigens.
Jiang
Y
Y
Department of Immunology, Stockholm University, Sweden.
Möller
G
G
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001324:Autoantigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D014184:Transplantation, Homologous
D001323:Autoantibodies; D001324:Autoantigens; D006183:H-2 Antigens; D008070:Lipopolysaccharides