A hypothesis on the pathogenesis of cancer: cancer might arise following an event of normal somatic cell fusing.
From the analysis and comparison of biological and abnormal chromosomal behaviour between cancer and hybrid cells, I hypothesize that cancer cells might arise from a hybrid cell which comes from normal somatic cell fusion, but obtains a proliferative advantage, a poorly-differentiated state and metastatic capacity. Furthermore, I put forward the concept that the hybridization between tissue cells and the peripheral blood stem cells may be more likely to generate malignant hybrids.
Qian
L W
LW
Department of Surgery, No. 2 Affiliated Hospital of Shandong Medical University, Jinan, Shandong, P.R. China.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002459:Cell Fusion; D002869:Chromosome Aberrations; D006801:Humans; D006822:Hybrid Cells / Q000473:pathology; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology