[Prevention of post-ovariectomy osteoporosis in the rat. Comparative study of synthetic salmon calcitonin and eel calcitonin aminosuberic analogue].
The authors evaluate the efficacy of salmon calcitonin and aminosuberic analogue of eel calcitonin in the prevention of post-oophorectomy osteoporosis in rats. Both drugs, administered at the same dosage, are equally effective in preventing oophorectomy bone loss in rats. Besides, plasma biochemical evaluations demonstrate that calcitonins reduce bone turnover in treated rats, compared with control oophorectomized ones.
Gnudi
S
S
Servizio Medicina Generale, Istituto Ortopedico Rizzoli, Bologna.
Zati
A
A
Giardino
R
R
Fini
M
M
Pratelli
L
L
Orlandi
M
M
Figus
E
E
D015502:Absorptiometry, Photon; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015415:Biomarkers; D001862:Bone Resorption / Q000517:prevention & control; D002116:Calcitonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D010052:Ovariectomy / Q000009:adverse effects; D010758:Phosphorus / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley
D015415:Biomarkers; D015675:Osteocalcin; D010758:Phosphorus; C028815:salmon calcitonin; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium; C012755:elcatonin
Prevenzione della osteoporosi post-ovariectomia nel ratto. Studio comparativo fra calcitonina sintetíca di salmone e derivato aminosuberico della calcitonina di anguilla.