Effects of intralesional injection of cisplatin on squamous cell carcinoma and normal tissue of mice.
Iodized oil as a drug carrier system for intralesional injection of cisplatin was assessed using human squamous cell carcinoma and normal tissues (kidney and small intestine) of BALB/c nu/nu mice. The results were compared to intralesional and intraperitoneal injections of cisplatin dissolved in distilled water. The following were assessed: change in tumor volume, increase or decrease in body weight of mice, and bromodeoxyuridine uptake of tumor, kidney and small intestine. Tissue platinum concentrations were also measured. Results showed that iodized oil may prove to be beneficial as a drug carrier system of cisplatin.
Landrito
J E
JE
Department of Oral and Maxillofacial Surgery 1, Hiroshima University School of Dentistry, Japan.
Yoshiga
K
K
Sakurai
K
K
Takada
K
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004337:Drug Carriers; D006801:Humans; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009368:Neoplasm Transplantation; D010984:Platinum / Q000378:metabolism / Q000493:pharmacokinetics; D013054:Spectrophotometry, Atomic
D004273:DNA, Neoplasm; D004337:Drug Carriers; D010984:Platinum; D001973:Bromodeoxyuridine; D002945:Cisplatin