Rational treatment for dyslipidemias.
High blood cholesterol is one of the three most common risk factors for cardiovascular disease. Several antihyperlipidemic agents are available to the prescriber; however, first line therapy is a diet low in cholesterol and saturated fats. The choice of therapy must be based on the type of abnormality present, concurrent disease states, side effect profiles, ease of use and cost. Several differences exist among the various dyslipidemic agents such as mechanism of action, effectiveness, pharmacokinetics, side effects, drug interactions and cost. For these reasons, this review focuses on the most commonly used dyslipidemic agents, e.g. the bile-acid sequestrants, nicotinic acid, fibric-acid derivatives and HMG-CoA reductase inhibitors.
Verzino
E M
EM
Charleston Area Medical Center, W.Va.
Kaplan
B
B
D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use
D000960:Hypolipidemic Agents