[The participation of the GABAergic system of the brain in shaping the breathing rhythm].
I.v. administration of sodium hydroxybutyrate induced periodic apneustic breathing with inspiratory arrests in anesthetised cats. Bilateral vagotomy did not change respiratory or circulatory parameters under these conditions. Administration of the same agent into both nuclei tractus solitarii induced similar effects, as well as administration of the GABA agonist baclofen. The data obtained suggest that the medullary GABA-ergic system takes an active part in generation of the respiration rhythm.
Kryzhanovskiĭ
G N
GN
Tarakanov
I A
IA
Safonov
V A
VA
D000818:Animals; D001049:Apnea / Q000139:chemically induced / Q000503:physiopathology; D001418:Baclofen / Q000494:pharmacology; D002415:Cats; D004576:Electromyography / Q000187:drug effects; D005260:Female; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D010507:Periodicity; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology*; D012119:Respiration / Q000187:drug effects / Q000502:physiology*; D012132:Respiratory Muscles / Q000187:drug effects / Q000502:physiology; D012978:Sodium Oxybate / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D001418:Baclofen
Uchastie GAMKergicheskoĭ sistemy mozga v formirovanii dykhatel'nogo ritma.