Intracranial arterial occlusion associated with high-activity iodine-125 brachytherapy for glioblastoma.
We describe two patients who developed devastating strokes due to intracranial arterial occlusion 15 weeks and 97 weeks following high dose stereotactic iodine-125 brachytherapy for glioblastoma multiforme. In both cases the occlusion was within the implant volume at points receiving 110-281 Gy and there was no other evidence of significant atherosclerosis in the patients. We therefore conclude that these complications were a direct result of the brachytherapy. The phenomenon of radiation-induced occlusion of large cerebral arteries is reviewed.
Bernstein
M
M
Division of Neurosurgery, Toronto Hospital, Ontario, Canada.
Lumley
M
M
Davidson
G
G
Laperriere
N
N
Leung
P
P
D001157:Arterial Occlusive Diseases / Q000209:etiology*; D001918:Brachytherapy / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002539:Cerebral Arterial Diseases / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage
D007457:Iodine Radioisotopes