title: The relationship between age and cognitive impairment in HIV-1 infection: findings from the Multicenter AIDS Cohort Study and a clinical cohort.
abstract: Previous studies have identified age as a risk factor for many neurologic disorders, and a "cerebral reserve" factor has been postulated to explain these findings. This study examined whether age represents a risk factor for HIV-1-related neuropsychological dysfunction. Subjects for study 1 were primarily asymptomatic seropositive (n = 1,066) and seronegative (n = 1,004) nonelderly male community volunteers who completed neuropsychological and reaction time measures. Data analyses revealed a significant effect for age on reaction time and timed neuropsychological measures, but no interaction between age and serostatus. Study 2, employing a similar neuropsychological battery, consisted of 76 seropositive men (29 over age 55) recruited from community outpatient clinics and 47 seronegative controls. We found serostatus and age to have main effects on a number of measures, but a trend for an effect of age-serostatus interaction on only one measure.
authors.affiliation: Department of Veterans Affairs Medical Center West Los Angeles, CA.
authors.forename: W G
authors.initials: WG
authors.lastname: van Gorp
authors.forename: E N
authors.initials: EN
authors.lastname: Miller
authors.forename: T D
authors.initials: TD
authors.lastname: Marcotte
authors.forename: W
authors.initials: W
authors.lastname: Dixon
authors.forename: D
authors.initials: D
authors.lastname: Paz
authors.forename: O
authors.initials: O
authors.lastname: Selnes
authors.forename: J
authors.initials: J
authors.lastname: Wesch
authors.forename: J T
authors.initials: JT
authors.lastname: Becker
authors.forename: C H
authors.initials: CH
authors.lastname: Hinkin
authors.forename: M
authors.initials: M
authors.lastname: Mitrushina
mesh_terms: D015526:AIDS Dementia Complex / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000375:Aging; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009483:Neuropsychological Tests