[Comparison of the effects of tianeptine and paroxetine on amnesic deficits induced by prolonged alcohol drinking in mice].
Previous experiments have shown that chronic ethanol consumption in mice for 12 months produced memory deficits associated with both alterations in diencephalic structures (ie, cellular loss, hypometabolism, particularly in mamillary bodies) and with hippocampal and cortical cholinergic hypofunction (Béracochéa et al., Pharmacol Biochem Behav 1992; 42: 749-53). The present study was aimed at comparing the effects of tianeptine and paroxetine (10 mg.kg-1, i.p.), that have opposite properties on serotoninergic transmission, on this alcohol-induced memory deficits. For this purpose, animals were submitted to a T-maze sequential alternation task in which they were given daily series of 6 successive trials separated by a 30-second interval. Behavioural testing began following a 4-week complete withdrawal period. The experiment was conducted in two steps. In the first part, animals received no treatment. Results showed that, as compared to the control group (pair-fed, n = 7), alcohol-treated mice (n = 20) displayed a trial-specific impairment of alternation rates. Specifically, they were impaired on the last three trials (4-6) of the series (52.2 vs 81.0%, p < 0.001), but performed normally on the first ones (2-3), suggesting thereby an increased sensitivity to proactive interference (Béracochéa et al., Behav Brain Res 1987; 25: 63-74). In the second part of the experiment the alcohol group was divided into three homogeneous groups according to the treatment they received 30 minutes before each daily session (ie, placebo, tianeptine, paroxetine).(ABSTRACT TRUNCATED AT 250 WORDS)
Béracochéa
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Laboratoire de Neurosciences Comportementales et Cognitives, CNRS URA 339, Université de Bordeaux I, Talence.
Deslandes
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Jaffard
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D000425:Alcohol Amnestic Disorder / Q000503:physiopathology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009949:Orientation / Q000187:drug effects / Q000502:physiology; D017374:Paroxetine / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D013841:Thiazepines / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine; D012701:Serotonin; D017374:Paroxetine
Comparaison des effets de la tianeptine et de la paroxétine sur les déficits mnésiques induits par la consommation prolongée d'alcool chez la souris.