Changes of myocardial myoglobin, myosin and creatine kinase in cases of sudden nocturnal death syndrome.
Myoglobin, myosin creatine kinase MM (CK-MM), creatine kinase BB(CK-BB) in cardiac muscle and H chain of myosin in atrial and ventricular muscle were studied in specimens from 8 patients who died of sudden nocturnal death syndrome (SNDS) by avidin-biotin complex (ABC) method to investigate the possible early or very early myocardial ischemia in the syndrome. Hematoxylin-eosin staining was conducted for comparison. The results showed evident loss of CK-MM, CK-BB, myoglobin and myosin from cardiac muscle cells, indicating that occurrence of SNDS is closely associated with acute myocardial ischemia.
Zhu
B L
BL
Department of Forensic Pathology, Faculty of Forensic Medicine, China Medical University, Shenyang.
Guan
D W
DW
Li
D X
DX
Tohru
O
O
Taizo
N
N
D000328:Adult; D003402:Creatine Kinase / Q000378:metabolism*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009211:Myoglobin / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D013577:Syndrome
D007527:Isoenzymes; D009211:Myoglobin; D003402:Creatine Kinase; D009218:Myosins