title: [Local antibiotic prophylaxis for repair of inguinal hernia].
abstract: A controlled randomized trial was carried out in 324 patients with inguinal hernia. Efficacy was evaluated of a single injection of cefamandole (n = 162) administered at operative site during local anesthesia, using an untreated group as control (n = 162), as prophylaxis against post-operative local infection. Seven patients in the control group developed abscesses at the operative site after discharge, 6 of the 7 during one-month follow up, compared with none in the treated group (n = 0.07). No side effects were reported due to the antibiotic therapy. The cost of the antibiotic treatment was 10 times less than that for treating the suppurations in the control group.
authors.affiliation: Service de Chirurgie Digestive et Générale, Hôpital de Purpan, Toulouse.
authors.forename: F
authors.initials: F
authors.lastname: Lazorthes
authors.forename: P
authors.initials: P
authors.lastname: Chiotasso
authors.forename: P
authors.initials: P
authors.lastname: Massip
authors.forename: J P
authors.initials: JP
authors.lastname: Materre
authors.forename: M
authors.initials: M
authors.lastname: Sarkissian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local / Q000379:methods*; D016470:Bacteremia / Q000209:etiology / Q000517:prevention & control*; D002435:Cefamandole / Q000627:therapeutic use*; D002648:Child; D004341:Drug Evaluation; D004927:Escherichia coli Infections / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control*; D013290:Streptococcal Infections / Q000209:etiology / Q000517:prevention & control
chemical_list: D002435:Cefamandole
vernacular_title: Antibioprophylaxie locale pour cure de hernie inguinale.