Inhibitory effects of Rooibos tea, Aspalathus linealis, on X-ray-induced C3H10T1/2 cell transformation.
Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous level. Suppression was also dependent on treatment time with the extract and was maximal when present during the entire incubation period. In contrast, green tea extract at an equitoxic concentration showed no detectable effect on transformation incidence.
Komatsu
K
K
Department of Radiation Biophysics, Nagasaki University School of Medicine, Japan.
Kator
K
K
Mitsuda
Y
Y
Mine
M
M
Okumura
Y
Y
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D013662:Tea; D014965:X-Rays
D016588:Anticarcinogenic Agents; D010936:Plant Extracts; D013662:Tea