title: Early histologic response to titanium implants complexed with bovine bone morphogenetic protein.
abstract: This study established a method for combining bovine bone morphogenetic protein (bBMP) with titanium and evaluated the early bone formation induced by the bBMP/titanium complex in edentulous dogs. Results showed newly formed bone within the interface bone 2 weeks after implantation and nearly complete osseointegration 4 weeks after implantation. Bone formed with the apical opening of the implant within 1 month. This study indicates that osseointegration can be enhanced by bBMP-bone induction. The apical opening of the implant may provide a site in which osteogenesis can occur with protection from implant stress before and after loading.
authors.affiliation: Department of Oral Pathology, Qin Du Stomatological College, Xi'an, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Yan
authors.forename: W
authors.initials: W
authors.lastname: Xiang
authors.forename: L
authors.initials: L
authors.lastname: Baolin
authors.forename: F H
authors.initials: FH
authors.lastname: White
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins; D002417:Cattle; D015921:Dental Implants; D004285:Dogs; D006133:Growth Substances / Q000494:pharmacology*; D008334:Mandible; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D011506:Proteins / Q000494:pharmacology*; D014025:Titanium
chemical_list: D019485:Bone Morphogenetic Proteins; D015921:Dental Implants; D006133:Growth Substances; D011506:Proteins; D014025:Titanium