title: Acute myeloid leukemia (AML-M1) with multiple trisomies and t(8;21)(q22;q22).
abstract: Cytogenetic analysis of an acute myeloid leukemia (AML-M1) showed the karyotype 53,XY, +6, +8,t(8;21)(q22;q22), +9, +10, +13, +19, +21. Only one AML with a massively hyperdiploid karyotype (> 50 chromosomes) and t(8;21) has been published before. A comparison of the two cases reveals similarities both with regard to the morphologic subtype (M1) and to which chromosomes were trisomic (+6, +8, +13, +19, and +21 were found in both cases). We surmise that the t(8;21) was the primary chromosomal abnormality and that the set of multiple trisomies occurred secondarily; this pattern of clonal evolution may have favored a more immature leukemic phenotype in these two cases than is regularly seen in t(8;21)-associated leukemias.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Köhler
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: J
authors.initials: J
authors.lastname: Ludvigsson
authors.forename: P
authors.initials: P
authors.lastname: Aman
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002648:Child; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D004171:Diploidy; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy; D014407:Tumor Cells, Cultured