[The protective activity of individual proteins and immunogenic fractions isolated from Rickettsia prowazekii].
The immunogenic properties and protective activity of basic protein I and tris-soluble antigens isolated from R. prowazekii were analyzed in comparison with those of chemical typhus vaccine on the model of anti-infectious immunity in guinea pigs. The analysis revealed that purified protein I has protective activity for guinea pigs, which is less pronounced in protein I from strain E with weak pathogenicity than protein I from strains EVir and Breinl. The activity and immunogenic properties of tris-soluble antigens, especially antigen I, are comparable with those of chemical typhus vaccines in the parameters under study.
Eremeeva
M E
ME
Balaeva
N M
NM
Genig
V A
VA
Rodionov
A V
AV
Belousova
L S
LS
Isachkova
I P
IP
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification; D000954:Antigens, Surface / Q000276:immunology / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000276:immunology* / Q000302:isolation & purification; D001428:Bacterial Vaccines / Q000276:immunology; D002642:Chick Embryo; D006168:Guinea Pigs; D007114:Immunization; D007117:Immunization, Secondary; D008297:Male; D012283:Rickettsia prowazekii / Q000276:immunology*; D012692:Serial Passage; D012995:Solubility; D013997:Time Factors; D014438:Typhus, Epidemic Louse-Borne / Q000276:immunology / Q000517:prevention & control
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001426:Bacterial Proteins; D001428:Bacterial Vaccines
Issledovanie protektivnoĭ aktivnosti individual'nykh belkov i immunogennykh fraktsiĭ, vydelennykh iz Rickettsia prowazekii.