[Free radical mechanisms of memory disorders of toxic origin and experimental therapy of the condition].
Influence of the pesticides deltametrin and dichlophos on memory processes and activity of the antioxidative enzymes superoxide dismutase (SOD) and catalase in the brain and blood of female rats was studied. Xenobiotics disturbed processes of formation and storage of signs of memory, which were tested in the conditional reaction of passive avoidance and in the conditional reaction of active avoidance; they also lowered SOD activity (but not catalase) in the brain (deltametrin by 25%, dichlophos by 21%) 3 h after their injection to the animals. Indices of SOD activity and blood catalase didn't change. SOD inhibition is suggested to be a result of the action of biotransformation product of deltametrin and dichlophos molecules on it, since in in vitro experiments pesticides don't exert influence on the inhibition kinetics of epinephrine autooxidation by brain homogenates. Prophylactic use of alpha-tocopherol or unithiol optimizes the processes of learning and memory in rats, intoxicated with these toxicants; a more marked antiamnestic, effect is observed in the combined injection of these preparations.
Gromov
L A
LA
Seredi
P I
PI
Syrovatskaia
L P
LP
Ovinova
G V
GV
Filonenko
M A
MA
D000818:Animals; D005260:Female; D005609:Free Radicals; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats
D005609:Free Radicals
Svobodnoradikal'nye mekhanizmy narusheniĭ pamiati toksicheskogo geneza i éksperimental'naia terapiia étogo sostoianiia.