[Immunohistochemical observations on 67 hemangioblastomas].
67 hemangioblastomas of three histological types were observed utilizing immunohistochemical methods. It was found that endothelia were positive for FVIII pericytes positive for desmin and stromal cells positive for NSE. All these cells expressed vimentin without significant difference. The difference in expression of the 4 antigens stated above was also not significant between the three cell types. These facts suggest that all the cells may have originated from primitive angiogenic mesenchymal cells and the three types of hemangioblastomas are different in morphology but have identical histogenesis. The cells positive for GFAP, S-100 and ACT are all astrocytes enveloped or buried in hemangioblastomas.
Yu
S Z
SZ
Department of Pathology, Tianjin Medical College.
D002528:Cerebellar Neoplasms / Q000737:chemistry / Q000473:pathology*; D003893:Desmin / Q000032:analysis; D018325:Hemangioblastoma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D003893:Desmin; D014746:Vimentin; D010751:Phosphopyruvate Hydratase