title: A new scalarane sesterterpenoid from the marine sponge Cacospongia mollior.
abstract: A new sesterterpene, 12-deacetoxyscalaradial [2a] has been isolated from the sponge Cacospongia mollior, together with the previously described scalaradial [2b] and furoscalarol [3]. The structure of the new compound, proposed by spectral data, was confirmed by X-ray diffraction analysis. Compound 2a is the first scalarane sesterterpenoid, without a substituent at C-12, to have been identified in nature. It shows high antifeedant activity and is hot to taste for the human tongue. Both 2a and 2b display cytotoxic activity.
authors.affiliation: Istituto per la Chimica di Molecole di Interesse Biologico CNR, Napoli, Italy.
authors.forename: S
authors.initials: S
authors.lastname: De Rosa
authors.forename: R
authors.initials: R
authors.lastname: Puliti
authors.forename: A
authors.initials: A
authors.lastname: Crispino
authors.forename: A
authors.initials: A
authors.lastname: De Giulio
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005247:Feeding Behavior / Q000187:drug effects; D005399:Fishes; D006718:Homosteroids / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007928:Lethal Dose 50; D013058:Mass Spectrometry; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013649:Taste / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D006718:Homosteroids; D013729:Terpenes; C087108:12-deacetoxyscalaradial