title: [The safety and protective properties of a new cell-free pertussis vaccine in animal trials].
abstract: The preclinical trial of a new cell-free pertussis vaccine has been carried out with a view to its comparison with whole-cell pertussis vaccine in respect of the toxic and protective properties of the preparations under experimental conditions. The whole-cell pertussis vaccine is characterized by pronounced toxic action causing leukocytosis and histamine-sensitization, produces a negative effect on the detoxifying function of the liver and possesses sensitizing activity. The cell-free pertussis vaccine has pronounced protective activity. In animal experiments the supposed immunization dose of this vaccine has proved to be nontoxic.
authors.forename: I G
authors.initials: IG
authors.lastname: Bazhanova
authors.forename: T N
authors.initials: TN
authors.lastname: Remova
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
authors.forename: E I
authors.initials: EI
authors.lastname: Shmeleva
authors.forename: N U
authors.initials: NU
authors.lastname: Mertsalova
authors.forename: E E
authors.initials: EE
authors.lastname: Sukhinova
authors.forename: R P
authors.initials: RP
authors.lastname: Chuprinina
authors.forename: V F
authors.initials: VF
authors.lastname: Bulk
authors.forename: I E
authors.initials: IE
authors.lastname: Semina
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Koval'skaia
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004356:Drug Storage; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification / Q000633:toxicity*; D013997:Time Factors; D014917:Whooping Cough / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine
vernacular_title: Issledovanie bezvrednosti i protektivnykh svoĭstv novoĭ beskletochnoĭ kokliushnoĭ vaktsiny v opytakh na zhivotnykh.