title: Reduced toxicity of a new formulation--peplomycin adsorbed on activated carbon particles--in mice.
abstract: We studied the acute toxicity and pathological effects of peplomycin adsorbed on fine activated carbon particles (PEP-CH) injected subcutaneously in mice. The 50% lethal dose value was 41.2 mg/kg in terms of peplomycin, which was 1.52 times that of the peplomycin aqueous solution (PEP-AQ) of 27.1 mg/kg. Deaths occurred from 5 to 31 days after administration of PEP-CH and from 5 to 22 days after administration of PEP-AQ solution. These figures are remarkably different from another report in which the mice given PEP-AQ died within 10 days.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Sawai
authors.forename: S
authors.initials: S
authors.lastname: Shoubayashi
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: S
authors.initials: S
authors.lastname: Muranishi
mesh_terms: D000327:Adsorption; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002244:Carbon; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D017663:Peplomycin / Q000008:administration & dosage / Q000633:toxicity*; D013535:Suspensions
chemical_list: D013535:Suspensions; D017663:Peplomycin; D002244:Carbon