title: Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.
abstract: Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.
authors.affiliation: Research Triangle Institute, Research Triangle Park, North Carolina 27709.
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: F
authors.initials: F
authors.lastname: Fullas
authors.forename: J B
authors.initials: JB
authors.lastname: Oswald
authors.forename: D M
authors.initials: DM
authors.lastname: Brown
authors.forename: T
authors.initials: T
authors.lastname: Santisuk
authors.forename: V
authors.initials: V
authors.lastname: Reutrakul
authors.forename: A T
authors.initials: AT
authors.lastname: McPhail
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D005419:Flavonoids; C087209:calycopterone