Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.
Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.
Rettig
J
J
Zentrum für Molekulare Neurobiologie Hamburg, Institut für Neurale Signalverarbeitung, Germany.
Heinemann
S H
SH
Wunder
F
F
Lorra
C
C
Parcej
D N
DN
Dolly
J O
JO
Pongs
O
O
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003001:Cloning, Molecular; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D051038:Large-Conductance Calcium-Activated Potassium Channel beta Subunits; D008564:Membrane Potentials / Q000502:physiology; D008969:Molecular Sequence Data; D009865:Oocytes / Q000502:physiology; D010446:Peptide Fragments; D015221:Potassium Channels / Q000737:chemistry* / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017386:Sequence Homology, Amino Acid; D014982:Xenopus laevis
C494839:Kcnab1 protein, rat; C494840:Kcnab3 protein, rat; D051038:Large-Conductance Calcium-Activated Potassium Channel beta Subunits; D010446:Peptide Fragments; D015221:Potassium Channels; D012333:RNA, Messenger