title: Thyrotoxicosis with osteomalacia and proximal myopathy.
abstract: A 36 year old lady, presented with symptoms of proximal myopathy was found to have a history of thyrotoxicosis for which she had taken carbimazole irregularly for 1-1/2 years. On admission, clinical signs of thyrotoxicosis were detected and confirmed by estimating serum T3 and T4. Neurological examination revealed generalised wasting, loss of power in the proximal muscles with a myopathy confirmed on EMG. Serum calcium, phosphorous levels, and a 24 hour urine calcium excretion were low. Alkaline phosphatase levels were high. A diagnosis of thyrotoxicosis with osteomalacia was made. The patient improved within 3 weeks of starting carbimazole and vitamin D.
authors.affiliation: Dept of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: R
authors.initials: R
authors.lastname: Goswami
authors.forename: P
authors.initials: P
authors.lastname: Shah
authors.forename: A C
authors.initials: AC
authors.lastname: Ammini
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D009135:Muscular Diseases / Q000209:etiology*; D010018:Osteomalacia / Q000150:complications*; D013971:Thyrotoxicosis / Q000150:complications*