Tubal sterilization by selective catheterization in an animal model.
OBJECTIVE
The feasibility of tubal occlusion by selective salpingography was tested in an animal model; three novel occluding materials also were tested for this application.


METHODS
Unilateral selective salpingography was performed in three groups of six rabbits; fallopian tubes were embolized with ethanol (group 1), a hydrogel (group 2), or an occluding emulsion (Ethibloc, Laboratoire Princeps, Neuilly sur Seine, France) (group 3). Animals were killed 2 days or 30 days after the procedure, according to randomization; tubal patency and histologic modifications were evaluated.


RESULTS
Selective tubal catheterization was obtained in 100% of the cases. In group 1, no satisfactory occlusion was obtained; in group 2, 65% of the tubes were occluded with little histologic damage; in group 3, 80% of the tubes were occluded, but significant inflammation and tissue necrosis were noted.


CONCLUSIONS
Selective salpingography proved a suitable method for gaining access to the fallopian tube and allowed selective injection of occluding materials. More research is needed to determine a suitable occluding material, focusing on biocompatibility and on long-term efficacy.
Maubon
A
A
Imagerie Medicale, C.M.C. Beausoleil, Montpellier, France.
Rouanet
J P
JP
Laurent
A
A
Joujoux
J M
JM
Cover
S
S
Courtieu
C
C
Wassef
M
M
Godlewski
G
G
Honiger
J
J
Lopez
F M
FM
D000818:Animals; D002404:Catheterization; D003973:Diatrizoate / Q000008:administration & dosage; D004338:Drug Combinations; D000431:Ethanol / Q000008:administration & dosage; D005187:Fallopian Tubes / Q000473:pathology; D005227:Fatty Acids / Q000008:administration & dosage; D005260:Female; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007047:Hysterosalpingography; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011409:Propylene Glycols / Q000008:administration & dosage; D011817:Rabbits; D015641:Radiography, Interventional; D011897:Random Allocation; D013246:Sterilization, Tubal / Q000379:methods*; D015028:Zein / Q000008:administration & dosage
D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D003973:Diatrizoate; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000431:Ethanol; D011092:Polyethylene Glycols; D015028:Zein; C020481:alcoholic prolamine solution