[The relationship of duodeno-gastric reflux index to histological changes and nuclear DNA contents in gastric stump mucosa dysplasia].
Dysplasia of gastric stump mucosa in 35 cases was studied. Evaluation of the entero-gastric reflux index(EGRI) was carried out by a computer radioisotope scanning. Dysplasia nuclear DNA content was measured using an automatic image analysis system. The results showed: (1) The severity of dysplasia in gastric stump mucosa increased with the increase of the mean values of the EGRI. The difference among all groups was highly significant (P < 0.001). (2) There appeared to be a significant positive correlation between EGRI and IOD, 2cDI, AREA or FORM PF, the correlation coefficients were 0.8927 (P < 0.001), 0.8631 (P < 0.001), 0.7845 (0.001 < P < 0.005), 0.7692 (0.001 < P < 0.005), respectively. (3) Significant differences were found among all groups for the mean interval between initial surgery and endoscopic examination (P < 0.001). From this study, a close relationship between dysplasia and entero-gastric reflux of the gastric stump could be postulated.
Cao
J
J
Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou.
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis; D004381:Duodenal Ulcer / Q000601:surgery; D004383:Duodenogastric Reflux / Q000150:complications*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011230:Precancerous Conditions / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000601:surgery
D004273:DNA, Neoplasm