Relation between resistance to beta-lactam antibiotics and cadmium in salmonellae isolated from pigs.
Of 50 Salmonella species isolated from pigs, 30 were resistant to cadmium and 18 of these also to azlocillin. The azlocillin-resistant isolates were resistant to cadmium at 80-500 mg/L CdSO4. A broader spectrum of resistance to azlocillin, ampicillin and cephazolin was found in strains resistant to < 200 mg/L CdSO4. Resistance to silver, mercury, chloramphenicol and streptomycin was independent of the resistance to beta-lactam antibiotics and Cd2+. Production and levels of beta-lactamase do not correlate with the spectrum of resistance.
Hustavová
H
H
Institute of Preventive and Clinical Medicine, Bratislava.
Vozárová
K
K
Havraneková
D
D
Jacková
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000378:metabolism; D002104:Cadmium / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008628:Mercury / Q000494:pharmacology; D012475:Salmonella / Q000187:drug effects* / Q000302:isolation & purification; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D012834:Silver / Q000494:pharmacology; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047090:beta-Lactams; D002104:Cadmium; D012834:Silver; D001618:beta-Lactamases; D008628:Mercury