[Therapeutic possibilities in the management of gastrointestinal bleeding in thrombocytopenic patients].
Gastrointestinal bleeding is often fatal in elderly. The danger could be multiplied by thrombocytopenia or by other disorder of the coagulation system. In a thrombocytopenic patient with myelodysplastic syndrome life threatening gastrointestinal bleeding occurred which could not be controlled by conventional methods (cimetidine, antacids, aminocaproic acid, platelet transfusions, blood transfusion 400-1200 ml/day). Continuous i.v. infusion of somatostatin [250 micrograms/hour Stilamin (Serono)] and per os omeprazole [2 x 1 capsule Losec (Astra)] resulted in the cessation of bleeding in 24 hours. Adverse effect was not observed.
Gurzó
M
M
Szent-Györgyi Albert Orvostudományi Egyetem, II. Belgyógyászati Klinika, Szeged.
Varga
G
G
Dobos
K
K
Náfrádi
J
J
Petri
A
A
D000368:Aged; D001778:Blood Coagulation Disorders / Q000150:complications; D001803:Blood Transfusion; D002927:Cimetidine / Q000627:therapeutic use; D004979:Ethamsylate / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications*; D017713:Platelet Transfusion; D011899:Ranitidine / Q000627:therapeutic use; D013917:Thrombin / Q000008:administration & dosage; D013921:Thrombocytopenia / Q000150:complications / Q000209:etiology*
D004979:Ethamsylate; D002927:Cimetidine; D011899:Ranitidine; D013917:Thrombin
Terápiás lehetöségek thrombocytopeniás beteg gastrointestinalis vérzésének kezelésében.