Effect of dopamine2 blockade on renal function under varied sodium intake.
This study explored the role of the dopamine-2 receptor (DA2) in the control of renal blood flow (RBF) and the influence of variations in sodium intake. These relationships have not been previously defined in man. Seven normotensive male subjects underwent a low dose dopamine (DA) infusion (1 microgram/kg.min) for 3 h, known to activate both DA1 and DA2 receptors. The effect of DA2 receptor on renal hemodynamics was studied using a relatively specific DA2 blocker [domperidone (DOM); 60 mg, orally] alone and with a DA infusion. Systemic and renal hemodynamics parameters were measured noninvasively. Urinary prostacyclin was measured in 3-h urine specimens, obtained during the DA infusion. The DA infusion increased RBF and prostacyclin during both normal and high salt diets, but this effect was attenuated on a low salt diet. DOM alone significantly reduced basal RBF during normal (1304 +/- 48 vs. 1175 +/- 45 mL/min.1.73 m2; P < 0.01) and low salt diets (1402 +/- 80 vs. 1220 +/- 101 mL/min.1.73 m2; P < 0.02), but was without effect during high sodium intake. DOM had no effect on prostacyclin excretion at any level of salt intake. These results suggest that both DA1 and DA2 are activated in renal vessels by DA, and that DA2 receptors play a role in the renal vasodilating action of DA. Changes in sodium balance alter the actions of the two receptors (DA1 and DA2) in a coordinated fashion in the regulation of RBF.
Bughi
S
S
University of Southern California, Los Angeles 90033.
Jost-Vu
E
E
Antonipillai
I
I
Nadler
J
J
Horton
R
R
D000328:Adult; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D011464:Epoprostenol / Q000652:urine; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D012083:Renin / Q000097:blood; D012982:Sodium, Dietary / Q000008:administration & dosage*
D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D012982:Sodium, Dietary; D004294:Domperidone; D011464:Epoprostenol; D012083:Renin; D004298:Dopamine