title: Problems in treating globus pharyngis.
abstract: Twenty-four out-patients with globus were assessed for current and past psychiatric illness with the 'Schedule for Affective Disorders and Schizophrenia-Lifetime Anxiety' version. Patients then received amitriptyline or placebo in a double-blind fashion. Treatment outcome was assessed using an inventory of throat symptoms, Beck Depression Inventory, Spielberger State Anxiety Scale, Crown-Crisp Experimental Index and General Health Questionnaire. Nine patients met the DMS-III criteria for psychiatric disorder in the past; six had suffered from panic disorder. Two further patients had been troubled by classic panic attacks. Nine of the 12 patients treated with amitriptyline and two of the placebo group discontinued treatment. In conclusion, clinical and psychometric associations were found between pathological anxiety and globus, and it appears that the recommendation that globus be treated 'aggressively' with tricyclic antidepressants is likely to lead to a high proportion of treatment failures.
authors.affiliation: Department of Psychology, University of Edinburgh, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Deary
authors.forename: J A
authors.initials: JA
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects / Q000627:therapeutic use*; D001007:Anxiety / Q000175:diagnosis; D003291:Conversion Disorder / Q000175:diagnosis / Q000188:drug therapy*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis; D009497:Neurotic Disorders / Q000175:diagnosis; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy*; D010352:Patient Dropouts; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D010919:Placebos; D012559:Schizophrenia / Q000175:diagnosis; D013001:Somatoform Disorders / Q000175:diagnosis
chemical_list: D010919:Placebos; D000639:Amitriptyline