title: [Antioxidative effect of mammalian liver hydrolyzate on lipid peroxidation].
abstract: The antioxidative effect of the mammalian liver hydrolyzate preparation (LH) was investigated mainly in the mouse liver homogenates. At lower concentrations, LH stimulated lipid peroxidation induced by Fe2+ and ascorbic acid in the homogenates, but inhibited completely the oxidation at higher concentrations. LH also inhibited the peroxidation of linolenic acid and linoleic acid. LH reduced 1,1-diphenyl-2-picrylhydrazyl, a free radical model, in a concentration-dependent manner, suggesting that the radical scavenging property of LH is involved in its antioxidative action. Fe2+ and glutathione, contained in LH, seem to act as a stimulator and an inhibitor of peroxidation, respectively.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aimoto
authors.forename: M
authors.initials: M
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Hiraki
authors.forename: C
authors.initials: C
authors.lastname: Dote
authors.forename: N
authors.initials: N
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Imai
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry*; D008297:Male; D051379:Mice; D014020:Tissue Extracts / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014020:Tissue Extracts