[Anatomo-pathologic diagnostic interpretation of nodular hepatic lesions].
Thirty cases of primary hepatic carcinomas and twenty hepatic metastatic localizations with equivocal histopathological features were investigated using morphologic criteria and immunohistochemical methods. The study was performed on formalin-fixed, paraffin-embedded tissue sections from surgical removed specimens. On the basis of our experience (in according with literature data) we have shown that most of hepatocellular carcinomas express a specific morphologic pattern (i.e. contemporary cholangiocellular differentiation) and phenotypic characters (particularly CEA positivity with bile canalicular pattern). Nevertheless in some cases it is impossible to make a differential diagnosis; the evaluation of new biological parameters like proliferative index will be useful.
Chiaramondia
M
M
Servizio di Anatomia Istologia e Citologia Patologica, Ospedale S. Martino di Genova.
Ceppa
P
P
Baccini
P
P
Badini
A
A
Castellaneta
A
A
D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D002454:Cell Differentiation; D018281:Cholangiocarcinoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
Interpretazione diagnostica anatomo-patologica delle lesioni nodulari epatiche.