Transfer of ochratoxin A from lactating rats to their offspring: a short-term study.
A dose-dependent transfer of ochratoxin A into the milk of lactating rats was found after a single oral dose of ochratoxin A, given in the dose levels of 10, 50, and 250-micrograms ochratoxin A/kg body weight by gastric intubation. The milk/blood concentration ratio of ochratoxin A at 24 and 72 h was 0.4 and 0.7, respectively. A linear relationship was found between the concentration of ochratoxin A in the dam's milk and in the blood of the pups at 72 h, as well as in the dam's milk and in the kidneys of the pups. The pup blood/milk concentration ratio of ochratoxin A was approximately 6. At 72 h the sucklings had higher levels of ochratoxin A than their dams in both blood and kidneys. The results show that the concentration of ochratoxin A in milk can be used as an indicator of the continuously administered dose to the suckling.
Breitholtz-Emanuelsson
A
A
Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
Palminger-Hallén
I
I
Wohlin
P O
PO
Oskarsson
A
A
Hult
K
K
Olsen
M
M
D000818:Animals; D000833:Animals, Suckling; D001692:Biological Transport; D005260:Female; D007668:Kidney / Q000378:metabolism; D008297:Male; D008892:Milk / Q000378:metabolism*; D009793:Ochratoxins / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009793:Ochratoxins; C025589:ochratoxin A