title: Apparent gossypol-induced toxicosis in adult dairy goats.
abstract: Consumption of a cotton-seed meal-based mineral supplement (cattle label) and a concentrate dairy mix (goat label) resulted in gossypol toxicosis in 3 adult dairy goats. The primary clinical signs were limb swelling and stiffness, ventral abdominal edema, and anorexia. All does died within a few days of the onset of illness. Necropsy revealed generalized subcutaneous edema, acute centrilobular necrosis of the liver, and myocardial fibrosis, consistent with a diagnosis of gossypol toxicosis. It was estimated that the does had consumed from 348 to 414 mg of free gossypol/d for at least 3 months. Apparent gossypol toxicosis in goats consuming this amount of free gossypol indicates that goats may be more susceptible than cattle to this substance.
authors.affiliation: Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: N E
authors.initials: NE
authors.lastname: East
authors.forename: M
authors.initials: M
authors.lastname: Anderson
authors.forename: L J
authors.initials: LJ
authors.lastname: Lowenstine
mesh_terms: D000821:Animal Feed / Q000506:poisoning*; D000818:Animals; D003369:Cottonseed Oil / Q000008:administration & dosage; D005260:Female; D015511:Goat Diseases / Q000139:chemically induced*; D006041:Goats; D006072:Gossypol / Q000008:administration & dosage / Q000506:poisoning*; D006333:Heart Failure / Q000139:chemically induced / Q000662:veterinary*; D011041:Poisoning / Q000150:complications / Q000662:veterinary
chemical_list: D003369:Cottonseed Oil; D006072:Gossypol