5-Fluorouracil combined with the pure [6S]-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study of two consecutive regimens.
Machover
D
D
Department of Oncology, Hospital Tenon, Paris, France.
Grison
X
X
Goldschmidt
E
E
Zittoun
J
J
Lotz
J P
JP
Metzger
G
G
Richaud
J
J
Hannoun
L
L
Marquet
J
J
Guillot
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000008:administration & dosage; D005492:Folic Acid / Q000097:blood / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage; D013237:Stereoisomerism
D011743:Pyrimidines; D005492:Folic Acid; D002955:Leucovorin; D005472:Fluorouracil