Early agalactosylation of IgG is associated with a more progressive disease course in patients with rheumatoid arthritis: results of a follow-up study.
The clinical significance of the percentage agalactosyl IgG oligosaccharides [%G(O)] was investigated in serum of a well-characterized cohort of 127 female RA patients who were followed for a mean duration of 6 yr. The %G(O) was determined in the first available serum sample which was obtained at a mean of 3.4 yr after symptom onset. It could be shown that patients with a %G(O) more than 2 S.D. above the mean level of controls (n = 34), had significantly more erosions, disease activity, and were treated with more second-line drugs, than patients without an increased %G(O) (n = 93), both at the time the serum sample was obtained, and during follow-up. These findings suggest that G(O) may serve as an indicator for the disease course in patients with RA.
van Zeben
D
D
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Rook
G A
GA
Hazes
J M
JM
Zwinderman
A H
AH
Zhang
Y
Y
Ghelani
S
S
Rademacher
T W
TW
Breedveld
F C
FC
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015804:HLA-DR4 Antigen / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis; D012720:Severity of Illness Index
D015804:HLA-DR4 Antigen; D007074:Immunoglobulin G; C064155:agalactosyl IGG; D012217:Rheumatoid Factor