title: Immune and serologic profiles of HIV-infected and noninfected hemophilic children and adolescents. Hemophilia Growth and Development Study Group.
abstract: OBJECTIVE
  To assess relationships among the effects of HIV on hemophilic children and adolescents' immunologic parameters and vaccine-related serology.
  
  
  METHODS
  We analyzed data from extensive baseline immunologic evaluations of 207 HIV antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic children and adolescents.
  
  
  RESULTS
  HIV+ and HIV- participants differed significantly in T-lymphocyte subpopulation numbers, immunoglobulin levels, and seroprevalence rates for diphtheria toxoid, measles, and mumps antigens, IgG levels, IgM levels, and serologic titers to vaccine antigens showed little correlation with T-cell parameters. Proportionately more HIV+ participants were nonreactive to each and all of a panel of 7 skin test antigens (71% vs 28% anergic, RR 2.6). The odds of anergy increased 1.6 times for every decline of 200 CD4+ cells/microliters.
  
  
  CONCLUSIONS
  HIV had significant, largely independent T- and B-lymphocyte effects on this pediatric cohort.
authors.affiliation: Division of HIV/AIDS, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333.
authors.forename: J
authors.initials: J
authors.lastname: Jason
authors.forename: J
authors.initials: J
authors.lastname: Murphy
authors.forename: L A
authors.initials: LA
authors.lastname: Sleeper
authors.forename: S M
authors.initials: SM
authors.lastname: Donfield
authors.forename: I
authors.initials: I
authors.lastname: Warrier
authors.forename: S
authors.initials: S
authors.lastname: Arkin
authors.forename: B
authors.initials: B
authors.lastname: Evatt
authors.forename: E D
authors.initials: ED
authors.lastname: Gomperts
mesh_terms: D000293:Adolescent; D000328:Adult; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis; D002648:Child; D015658:HIV Infections / Q000150:complications*; D006467:Hemophilia A / Q000097:blood / Q000150:complications* / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D016131:Lymphocyte Subsets / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D012882:Skin Tests; D014612:Vaccines / Q000276:immunology
chemical_list: D000941:Antigens; D015704:CD4 Antigens; D007136:Immunoglobulins; D014612:Vaccines