Variations in chromosome size and organization in Candida albicans and Candida stellatoidea.
Candida albicans and the closely related species Candida stellatoidea are medically important diploid asexual yeasts. Clinical isolates frequently show variant electrophoretic karyotypes, apparently due largely to chromosomal translocations. These translocations seem to occur at hot spots characterized by the repeated DNA sequence RSP1. A programmed karyotypic rearrangement occurs in C. stellatoidea. Karyotypic rearrangement may serve as a source of genetic variation in these asexual yeasts.
Magee
P T
PT
Dept of Genetics and Cell Biology, University of Minnesota, St Paul 55108.
D002175:Candida / Q000235:genetics*; D002176:Candida albicans / Q000235:genetics*; D002874:Chromosome Mapping; D015825:Chromosomes, Fungal; D015321:Gene Rearrangement; D014178:Translocation, Genetic