Some comments on potency measures in mutagenicity research.
In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses specific areas of research that might benefit from a study of potency.
Margolin
B H
BH
Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill 27599-7400.
Kim
B S
BS
Smith
M G
MG
Fetterman
B A
BA
Piegorsch
W W
WW
Zeiger
E
E
D004305:Dose-Response Relationship, Drug; D015386:Hazardous Substances / Q000633:toxicity*; D009152:Mutagenicity Tests / Q000706:statistics & numerical data; D012475:Salmonella / Q000187:drug effects*
D015386:Hazardous Substances