Structure of the mouse growth/differentiation factor 9 gene.
Using a mouse GDF-9 cDNA as a probe, over 20 kb of sequence encompassing the GDF-9 gene was isolated from a mouse 129SvEv genomic library. Sequence analysis of the exons, exon-intron boundaries, and 5'- and 3'-non-translated regions was used to establish the structure of the mouse GDF-9 gene. The GDF-9 gene is encoded by two exons separated by a 2.9 kb intron. Multiple putative transcription start sites are detected between 31 and 57 bp upstream of the start site of translation and a putative polyadenylation signal lies 342 bp 3' of the end of translation. Knowledge of the GDF-9 gene structure will enable us to further understand the role of GDF-9 in ovarian physiology and development.
Incerti
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Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
Dong
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Borsani
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Matzuk
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MM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D055430:Bone Morphogenetic Protein 15; D005260:Female; D055429:Growth Differentiation Factor 9; D006133:Growth Substances / Q000737:chemistry*; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010053:Ovary / Q000737:chemistry / Q000502:physiology
C525902:Bmp15 protein, mouse; D055430:Bone Morphogenetic Protein 15; C525898:Gdf9 protein, mouse; D055429:Growth Differentiation Factor 9; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins