title: Cigarette smoking and functional ovarian cysts.
abstract: This population-based case-control study assessed the effect of current cigarette smoking on the risk of functional ovarian cyst development. Cases were all 15-39 year-old enrollees of Group Health Cooperative of Puget Sound (GHC) who had either an inpatient primary diagnosis of functional ovarian cyst in 1988 or 1989 (n = 61) or an outpatient primary diagnosis of functional ovarian cyst at five GHC primary care clinics (n = 37). Controls were randomly selected enrollees matched to cases on age, primary care clinic, and enrollment date (n = 239). A total of 36.7% of cases and 20.5% of controls were determined by medical record review to be current smokers. Compared with women who were not current smokers, the relative risk of a diagnosed functional ovarian cyst among smokers was 2.0 (95% confidence interval 1.1-3.5). This finding, in an area of little previous research, provides a promising lead in the investigation of the etiology of functional ovarian cysts and the effects of smoking on ovarian function in general.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA.
authors.forename: V L
authors.initials: VL
authors.lastname: Holt
authors.forename: J R
authors.initials: JR
authors.lastname: Daling
authors.forename: B
authors.initials: B
authors.lastname: McKnight
authors.forename: D E
authors.initials: DE
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Stergachis
authors.forename: N S
authors.initials: NS
authors.lastname: Weiss
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006279:Health Maintenance Organizations; D006801:Humans; D016015:Logistic Models; D016555:Matched-Pair Analysis; D010048:Ovarian Cysts / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D011159:Population Surveillance; D012306:Risk; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D014861:Washington / Q000453:epidemiology