Viral persistence of simian type D retrovirus (SRV-2/W) in naturally infected pigtailed macaques (Macaca nemestrina).
To elucidate sites of SRV-2/W persistence, tissue DNA from three groups of naturally infected Macaca nemestrina was analyzed for provirus: vertically transmitted, viremic, seronegative macaques; horizontally transmitted, viremic, seronegative macaques, and nonviremic seropositive macaques. In viremic animals infected vertically, provirus was found in many tissues, whereas in those infected horizontally, proviral DNA was limited. In V-Ab+ macaques, provirus was detected in bone marrow and/or ileocecal junction, confirming the presence of provirus in V-Ab+ animals.
Moazed
T C
TC
Department of Pathobiology, School of Public Health, University of Washington, Seattle 98195.
Thouless
M E
ME
D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D008254:Macaca nemestrina / Q000382:microbiology*; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology / Q000382:microbiology*; D015995:Prevalence; D011533:Proviruses / Q000302:isolation & purification; D012192:Retroviridae Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D015301:Retroviruses, Simian / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D016036:Seroepidemiologic Studies; D016097:Simian Acquired Immunodeficiency Syndrome / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D014766:Viremia / Q000382:microbiology / Q000662:veterinary
D004279:DNA, Viral