title: 3 cases of anti-Scl-70 (topoisomerase I) antibody associated with central nervous system lupus without renal disorder.
abstract: We describe 3 cases of systemic lupus erythematosus (SLE) associated with anti-Scl-70 antibody. Common symptoms were central nervous system disorder, discoid rash, lymphadenopathy, and no renal disorder. Two of 3 cases showed some symptoms of scleroderma but could not be diagnosed as such. Although further followup is required to determine if scleroderma develops, these unique symptoms might be a subtype of SLE or a lupus-like syndrome characterized by symptoms and anti-Scl-70 antibody.
authors.affiliation: Second Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mukai
authors.forename: A
authors.initials: A
authors.lastname: Sagawa
authors.forename: T
authors.initials: T
authors.lastname: Atsumi
authors.forename: S
authors.initials: S
authors.lastname: Jodo
authors.forename: Y
authors.initials: Y
authors.lastname: Amasaki
authors.forename: T
authors.initials: T
authors.lastname: Nakabayashi
authors.forename: I
authors.initials: I
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Fujisaku
authors.forename: S
authors.initials: S
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis*; D002493:Central Nervous System Diseases / Q000276:immunology*; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D012871:Skin Diseases / Q000150:complications
chemical_list: D000906:Antibodies; D004264:DNA Topoisomerases, Type I