[Role of hemoglobin in adaptation to hypoxia in patients with iron-deficiency anemia].
To define Hb role in compensation of hemic hypoxia, the authors studied HbO2 dissociation curves (HDC), blood acid-base equilibrium, concentrations of 2,3-DPG and creatinine in red cells from females with moderate iron-deficiency anemia resultant from frequent haemorrhages. This form of anemia was found associated with a 34% increase in the level of 2,3-DPG against normal amounts of other two ligands essential to Hb affinity to oxygen, i.e. H+ ions and CO2. A 3-fold increase in creatinine concentrations and its direct relationship with 2,3-DPG quantitative characteristics gave ground for considering rejuvenescence of the red cells in the peripheral blood to be the underlying factor in enhancement of 2,3-DPG synthesis. A 2,3-DPG-induced in vivo HDC shift to the right by 2.5 mmHg stimulates oxygen release from HbO2. The resultant 15% additional oxygen partially compensates for low Hb blood levels in the anemic patients.
Dmitrieva
M G
MG
Karpova
I V
IV
Pivnik
A V
AV
Gazenko
L O
LO
Valova
G M
GM
D000222:Adaptation, Physiological; D000747:Anemia, Hypochromic / Q000097:blood* / Q000150:complications; D005260:Female; D006454:Hemoglobins / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000150:complications
D006454:Hemoglobins
Rol' gemoglobina v adaptatsii k gipoksii bol'nykh zhelezodefitsitnoĭ anemieĭ.