Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine.
Flumazenil is an important adjunct to the diagnosis and treatment of benzodiazepine toxicity. It must be used cautiously with attention to a number of clinical caveats. Currently it is advised that flumazenil should not be used routinely in all patients with altered mental status, but when used selectively, it is a very safe and extremely useful antidote.
Doyon
S
S
Department of Emergency Medicine, Mercy Catholic Medical Center, Philadelphia, Pennsylvania.
Roberts
J R
JR
D000818:Animals; D003128:Coma / Q000188:drug therapy*; D004630:Emergencies; D005442:Flumazenil / Q000009:adverse effects / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use*; D013831:Thiamine / Q000627:therapeutic use*
D009270:Naloxone; D005442:Flumazenil; D005947:Glucose; D013831:Thiamine