Naloxone antagonizes ethanol- but not gamma-hydroxybutyrate-induced sleep in mice.
The present study examined the effect of naloxone on ethanol- and gamma-hydroxybutyric acid-induced narcosis in mice and the changes induced by these drugs on striatal dopamine metabolism. The results show that naloxone (1-10 mg/kg s.c.) markedly reduced ethanol-induced narcosis but failed to modify the duration of sleep induced by gamma-hydroxybutyrate. Naloxone (10 mg/kg) modified neither ethanol- nor gamma-hydroxybutyrate-induced changes in striatal dopamine and dihydroxyphenylacetic acid (DOPAC) content. The results suggest that gamma-hydroxybutyrate- and ethanol-induced narcosis are mediated by different mechanisms and that opioid receptors are not involved in the changes in dopamine metabolism induced by these compounds.
Devoto
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P
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Colombo
G
G
Cappai
F
F
Gessa
G L
GL
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000037:antagonists & inhibitors*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012978:Sodium Oxybate / Q000494:pharmacology*
D015102:3,4-Dihydroxyphenylacetic Acid; D009270:Naloxone; D000431:Ethanol; D012978:Sodium Oxybate; D004298:Dopamine