Dissecting the assembly of orbiviruses.
Virus assembly within infected cells involves a precise sequence of macromolecular interactions. To unravel the individual steps involved in the assembly of a complete virion of bluetongue virus, we have engineered a series of recombinant baculoviruses to make multicomponent structures resembling virus structures. When combined with cryoelectron microscopy and image processing techniques the data reveal the organization and assembly of the various components of this virus.
Roy
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University of Oxford, NERC IVEM, Oxford, UK.
D016367:Baculoviridae / Q000235:genetics; D002213:Capsid / Q000096:biosynthesis / Q000737:chemistry; D018163:Orbivirus / Q000737:chemistry* / Q000648:ultrastructure; D015678:Viral Structural Proteins / Q000032:analysis; D014771:Virion / Q000737:chemistry / Q000648:ultrastructure
D015678:Viral Structural Proteins