title: [Role of hemoglobin in adaptation to hypoxia in patients with iron-deficiency anemia].
abstract: To define Hb role in compensation of hemic hypoxia, the authors studied HbO2 dissociation curves (HDC), blood acid-base equilibrium, concentrations of 2,3-DPG and creatinine in red cells from females with moderate iron-deficiency anemia resultant from frequent haemorrhages. This form of anemia was found associated with a 34% increase in the level of 2,3-DPG against normal amounts of other two ligands essential to Hb affinity to oxygen, i.e. H+ ions and CO2. A 3-fold increase in creatinine concentrations and its direct relationship with 2,3-DPG quantitative characteristics gave ground for considering rejuvenescence of the red cells in the peripheral blood to be the underlying factor in enhancement of 2,3-DPG synthesis. A 2,3-DPG-induced in vivo HDC shift to the right by 2.5 mmHg stimulates oxygen release from HbO2. The resultant 15% additional oxygen partially compensates for low Hb blood levels in the anemic patients.
authors.forename: M G
authors.initials: MG
authors.lastname: Dmitrieva
authors.forename: I V
authors.initials: IV
authors.lastname: Karpova
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik
authors.forename: L O
authors.initials: LO
authors.lastname: Gazenko
authors.forename: G M
authors.initials: GM
authors.lastname: Valova
mesh_terms: D000222:Adaptation, Physiological; D000747:Anemia, Hypochromic / Q000097:blood* / Q000150:complications; D005260:Female; D006454:Hemoglobins / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000150:complications
chemical_list: D006454:Hemoglobins
vernacular_title: Rol' gemoglobina v adaptatsii k gipoksii bol'nykh zhelezodefitsitnoĭ anemieĭ.