[Toxoplasmosis and cytomegalovirus serology in patients infected with HIV in Congo].
Cerebral toxoplasmosis and cytomegalovirus (CMV) infection are very frequent in AIDS. Biological markers of toxoplasmosis and CMV were studied in blood and cerebrospinal fluid (CSF) of 121 HIV-positive and 35 HIV-negative patients in the Central Hospital of the Congolese Army in Brazzaville. In the case of clinically suspected cerebral toxoplasmosis, the simultaneous presence of specific IgG antibodies in the blood and in the CSF can be considered as having complementary diagnostic value (PPV = 63.3%, NPV = 89.9%). The symptomatology of AIDS is very polymorphous and includes various etiological factors; as a result it is very difficult to estimate the responsibility of cytomegalovirus in the absence of positive viral culture, even with the simultaneous presence of specific IgG antibodies in the blood and CSF (PPV = 75.7%, NPV = 54.6%).
Makuwa
M
M
Service de virologie, laboratoire national de santé publique, BP 120, Brazzaville, Congo.
Loemba
H
H
Ngouonimba
J
J
Beuzit
Y
Y
Louis
J P
JP
Livrozet
J M
JM
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood* / Q000134:cerebrospinal fluid; D000914:Antibodies, Viral / Q000097:blood* / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003223:Congo / Q000453:epidemiology; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000453:epidemiology*; D005260:Female; D015497:HIV-1; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D015995:Prevalence; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D014122:Toxoplasma / Q000276:immunology*; D016781:Toxoplasmosis, Cerebral / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000453:epidemiology*
D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D015415:Biomarkers; D007074:Immunoglobulin G
Sérologie de la toxoplasmose et du cytomégalovirus des malades infectés par le VIH au Congo.