title: Study of pulpal response to an adhesive composite resin restoration using A NPG primer and a PMDM monomer (Mirage-Bond).
abstract: The purpose of this experiment was to investigate histo-pathologically and clinico-pathologically the pulpal reaction to a composite resin restoration system with a NPG primer and an adhesive bonding agent containing a carboxylate adhesive monomer, PMDM, using beagle dog and human teeth. The contact area between the composite resin with the primer and the monomer and the dentin cavity wall was observed through the SEM imaging. In the histo-pathological study, the average evaluation score of pathological results in group M (the composite resin restoration using the NPG primer and the bonding agent containing PMDM monomer "Mirage-Bond") was superior and almost the same as in group P as a contrast group (the composite resin restoration using a bonding agent "Clearfil Photo Bond" after enamel and dentin wall etching with 40% phosphoric acid). The dispersion of pathological results by score in group M was much narrower than in group P. Microorganism growth in group M was less than that of group P. Gap spaces caused by coming off in the region of contact area between the filled resin and the dentin cavity wall were observed through the SEM imaging. The number of cases coming off in group M were fewer than in group P. Gap spaces in group M were narrower in width than in group P. In the SEM imaging, microorganisms were observed in most cases with gap areas. In the clinico-pathological study on restoration with "Mirage-Bond", unpleasant sings symptoms had not occurred except in a few cases. The pathological result by score was comparatively superior. The pathological results of human teeth were similar to the pathological results of dog teeth. The pulpal irritation due to this composite resin restoration system with the NPG primer and the PMDM monomer containing adhesive bonding agents was generally minor, and the system was considered to be safe and useful even though the contraction gap spaces were found in some cases.
authors.affiliation: The Third Department of Conservative Dentistry, Tokyo Dental College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000633:toxicity*; D003188:Composite Resins / Q000633:toxicity*; D003763:Dental Leakage; D003782:Dental Pulp / Q000187:drug effects* / Q000648:ultrastructure; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D017220:Dentin-Bonding Agents / Q000633:toxicity*; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000633:toxicity*; D008855:Microscopy, Electron, Scanning; D019279:Resin Cements
chemical_list: D003188:Composite Resins; D017220:Dentin-Bonding Agents; D008689:Methacrylates; C070605:Mirage-Bond; D019279:Resin Cements; C074669:Clearfil Photo Bond; D017438:Bisphenol A-Glycidyl Methacrylate