Serological characteristics of partial D antigen category VI in 8 unrelated blood donors.
Classification of subjects with a partial D antigen is traditionally performed with immune anti-D sera. The development of monoclonal antibodies enables a fine analysis to be made of the specificity of the epitopes that are present or missing in these cases. A systematic search in a Caucasian donor population of 17,500 revealed 8 unrelated male individuals (frequency 0.05%) with a red cell phenotype characteristic of partial D category VI, but without anti-D in their serum. The relation to the 'classic' partial D category VI was investigated and is discussed, as is the observed serological heterogeneity of the partial D category VI group. Clinical consequences for the prevention of immunization of these subjects are mentioned.
van Rhenen
D J
DJ
Red Cross Bloodbank Rotterdam, The Netherlands.
Thijssen
P M
PM
Overbeeke
M A
MA
D000911:Antibodies, Monoclonal / Q000276:immunology; D001782:Blood Donors; D001788:Blood Grouping and Crossmatching; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008403:Mass Screening; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000032:analysis* / Q000235:genetics; D018029:Rho(D) Immune Globulin / Q000097:blood; D044465:White People / Q000235:genetics
D000911:Antibodies, Monoclonal; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin