Interleukin-1 receptor type I mRNA in mouse brain as affected by peripheral administration of bacterial lipopolysaccharide.
Following administration of endotoxin in vivo, alterations of interleukin-1 (IL-1) receptor binding have been reported. In order to assess in vivo regulation of IL-1 receptor gene expression in brain, mRNA levels for IL-1 receptor type I were measured after peripheral administration of bacterial lipopolysaccharide in mice. When 25 micrograms of lipopolysaccharide were administered intraperitoneally, IL-1 receptor type I mRNA in the brain was increased after 3 h. After 20 h, the level was diminished. This result suggests that bacterial lipopolysaccharide affects regulation of IL-1 receptor type I mRNA expression in mouse brain.
Reinisch
N
N
Department of Internal Medicine, University of Innsbruck, Austria.
Wolkersdorfer
M
M
Kähler
C M
CM
Ye
K
K
Dinarello
C A
CA
Wiedermann
C J
CJ
D000818:Animals; D015152:Blotting, Northern; D001923:Brain Chemistry / Q000187:drug effects*; D004926:Escherichia coli; D017403:In Situ Hybridization; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011061:Poly A / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis*; D015854:Up-Regulation / Q000187:drug effects
D008070:Lipopolysaccharides; D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D011061:Poly A