Relevance of broad-spectrum and fungicidal activity of antifungals in the treatment of dermatomycoses.
The in vitro fungistatic and fungicidal activities of terbinafine, amorolfine and itraconazole against dermatophytes were compared. All three compounds showed very good activity against all dermatophyte species tested, but only terbinafine and amorolfine exhibited primary fungicidal activity. These two compounds were also active in vitro against other filamentous fungi which cause onychomycoses, such as Scytalidium and Scopulariopsis species.
Clayton
Y M
YM
St John's Institute of Dermatology, St Thomas' Hospital, London, U.K.
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D009025:Morpholines / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D000077291:Terbinafine
D000935:Antifungal Agents; D009025:Morpholines; D009281:Naphthalenes; D017964:Itraconazole; C038974:amorolfine; D000077291:Terbinafine