Post-prandial Lp(a): identification of a triglyceride-rich particle containing apo E.
A VLDL-like particle containing the apo B100-apo(a) complex was isolated from the post-prandial plasma of subjects fed a fat meal enriched in saturated fatty acids. The abundance of this lipoprotein particle, that we call TG-Lp(a), varied among subjects but not in the same subject. TG-Lp(a), but not the classic Lp(a), contained apo E; this apolipoprotein may cause divergence in cellular uptake and degradation between these two classes of lipoproteins.
Scanu
A M
AM
Department of Medicine, University of Chicago, IL 60637.
Pfaffinger
D
D
Edelstein
C
C
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage; D004435:Eating; D005227:Fatty Acids / Q000008:administration & dosage; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood* / Q000737:chemistry; D008075:Lipoproteins, HDL / Q000097:blood / Q000172:deficiency; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood*
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D004041:Dietary Fats; D005227:Fatty Acids; D017270:Lipoprotein(a); D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides