[Cytotoxic cytokines in multiple sclerosis].
Cytokines are essential mediators of cell-to-cell communication in many physiological and pathophysiological processes. During the last few years a lot of data has accumulated suggesting that some of them may be involved in the pathomechanism of multiple sclerosis (MS). One of the most extensively studied is a cytotoxic cytokine--tumour necrosis factor (THF) which has demyelinating activity in vitro and in vivo. Similar in structure and functions is another cytotoxic cytokine-lymphotoxin (LT). In the article recent information about studies of TNF and LT in MS were reviewed.
Głabiński
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Kliniki Neurologii AM, Lodzi.
D003711:Demyelinating Diseases / Q000276:immunology; D006801:Humans; D008233:Lymphotoxin-alpha / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha
Cytokiny cytotoksyczne w stwardnieniu rozsianym.