BE-23372M, a novel protein tyrosine kinase inhibitor. II. Physico-chemical properties and structure elucidation.
BE-23372M, a new protein tyrosine kinase inhibitor, has been obtained as a reddish orange solid. The compound, C17H12O6, HRFAB-MS: m/z 312.0625 (M)+, is an acidic substance, showing UV (MeOH) lambda max (epsilon) 266 (8,800), 426 nm (20,400), and IR (KBr)vmax 1752(C = O) and 3298(OH) cm-1. The structure of BE-23372M, (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-fur anone, has been elucidated by 1H and 13C NMR studies.
Tanaka
S
S
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
Okabe
T
T
Nakajima
S
S
Yoshida
E
E
Suda
H
H
D002855:Chromatography, Thin Layer; D005663:Furans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000737:chemistry*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D005663:Furans; D010636:Phenols; C087122:BE 23372M; D011505:Protein-Tyrosine Kinases