title: [Ring-cell immunocytoma with polyneuropathy associated with dysgammaglobulinemia and amyloidosis].
abstract: Dysgammaglobulinemia, amyloidosis and generalization of tumour occurred step by step in sensomotoric polyneuropathy complicating a nonspecified malignant lymphoma. The tumor was specified later as a IgM lambda immunocytoma with substantial participation of signet ring cells. Their vacuoles were sometimes multivesicular and did not contain immunoglobulins. Final phase of the disease was characterized by nodular AL amyloidosis expressed especially in the lung, retroperitoneum and nervous system. Amyloidosis was connected with the vessel walls and their surroundings. Possible autoimmune pathogenesis of polyneuropathy as well as of immunocyte vacuolization were discussed.
authors.affiliation: Hlavův I. patologicko-anatomický ústav, I. interní klinika 1. LF KU, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Horová
authors.forename: B
authors.initials: B
authors.lastname: Bednár
authors.forename: E
authors.initials: E
authors.lastname: Benesová
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M; D008223:Lymphoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D007075:Immunoglobulin M
vernacular_title: Immunocytom z prstencitých bunĕk s polyneuropatií pri dysgamaglobulinémii a amyloidóze.