title: Successful administration of low molecular weight heparin in a patient with heparin-induced thrombocytopenia and coumarin-induced skin necrosis.
abstract: A case of heparin-induced thrombocytopenia and skin necrosis induced by coumarin is reported in a 58-year-old female patient suffering from metastatic breast adenocarcinoma and deep vein thrombosis. The thrombosis resolved after treatment with low molecular weight heparin and the thrombocytopenia recovered within a few days. The occurrence of both these rare complications in the same patient has not been previously reported in the literature. We present a review of these complications and their current treatment.
authors.affiliation: Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Drakos
authors.forename: B
authors.initials: B
authors.lastname: Uziely
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.forename: S
authors.initials: S
authors.lastname: Gillis
authors.forename: A
authors.initials: A
authors.lastname: Eldor
mesh_terms: D000074:Acenocoumarol / Q000009:adverse effects*; D000230:Adenocarcinoma / Q000150:complications / Q000556:secondary / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology; D003131:Combined Modality Therapy; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D012867:Skin / Q000473:pathology*; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary / Q000628:therapy; D013921:Thrombocytopenia / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000150:complications / Q000188:drug therapy*
chemical_list: D017984:Enoxaparin; D006493:Heparin; D000074:Acenocoumarol