Aplastic anemia induced by cyclohexylchloroethylnitrousurea.
We report a patient who developed aplastic anemia after three courses of cyclohexylchloroethylnitrousurea (CCNU), procarbazine and oncovine administered after craniotomy and irradiation for brain astrocytoma. To the best of our knowledge, aplastic anemia following CCNU has not been reported previously. The unique course of the disease and implications of this complication are discussed.
Elis
A
A
Department of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Kfar Saba, Israel.
Lishner
M
M
Savin
H
H
Ravid
M
M
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001254:Astrocytoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D001772:Blood Cell Count / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine