Central nervous system IgG synthesis rates in Alzheimer disease: possible differences in early-onset and late-onset subgroups.
Central nervous system IgG synthesis rates were determined for 51 patients with autopsy-confirmed Alzheimer disease and 23 age-matched controls. Rates were no different between patients and controls when overall groups were compared. Age-at-dementia-onset data were available on 37 patients. Comparisons of 11 early-onset (< 65 years of age) patients with 26 late-onset patients revealed significantly increased intrathecal IgG synthesis rates for the late-onset group. These results suggest that IgG synthesis may be a contributing pathogenic factor in a subgroup of patients with late-onset Alzheimer disease.
Small
G W
GW
Department of Psychiatry, UCLA School of Medicine.
Rosenthal
M
M
Tourtellotte
W W
WW
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008297:Male; D012016:Reference Values; D012307:Risk Factors
D007074:Immunoglobulin G