Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.
We have investigated the possible effect of estrogen on the metabolism of the Alzheimer amyloid precursor protein (APP). Using a cell line that contains high levels of estrogen receptors, we have found that treatment with physiological concentrations of 17 beta-estradiol is associated with accumulation in the conditioned medium of an amino-terminal cleavage product of APP (soluble APP or protease nexin-2), indicative of non-amyloidogenic processing. There were no obvious changes in the levels of intracellular immature or mature APP holoproteins, suggesting that estrogen may increase the secretory metabolism of APP.
Jaffe
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Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021.
Toran-Allerand
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Greengard
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Gandy
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SE
D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D017077:Culture Media, Conditioned; D004958:Estradiol / Q000502:physiology*; D006801:Humans; D014407:Tumor Cells, Cultured
D016564:Amyloid beta-Protein Precursor; D017077:Culture Media, Conditioned; D004958:Estradiol