Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.
Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.
Wall
M E
ME
Research Triangle Institute, Research Triangle Park, North Carolina 27709.
Wani
M C
MC
Fullas
F
F
Oswald
J B
JB
Brown
D M
DM
Santisuk
T
T
Reutrakul
V
V
McPhail
A T
AT
Farnsworth
N R
NR
Pezzuto
J M
JM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D005419:Flavonoids; C087209:calycopterone