Intravaginal inoculation of mice with the Chlamydia trachomatis mouse pneumonitis biovar results in infertility.
In an attempt to establish a model of chlamydial ascending salpingitis and infertility, three inbred strains of mice, C3H/HeN (H-2k), C57BL/6N (H-2b), and BALB/cAnN (H-2d), were inoculated intravaginally with 3 x 10(7) inclusion-forming units of the Chlamydia trachomatis mouse pneumonitis biovar. Mice mated 6 weeks following inoculation were found to have a significant decrease in fertility rate compared with the control groups, as shown by a reduction in the number of pregnant mice and a decrease in the number of embryos.
de la Maza
L M
LM
Department of Pathology, University of California, Irvine 92717-4800.
Pal
S
S
Khamesipour
A
A
Peterson
E M
EM
D000818:Animals; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis; D005260:Female; D007247:Infertility, Female / Q000209:etiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D014621:Vagina / Q000382:microbiology*