title: Influence of ochratoxin A and diacetoxyscirpenol singly and in combination on broiler chickens.
abstract: The effects of feeding 2 mg ochratoxin A (OA) and 6 mg 4,15-diacetoxyscirpenol (DAS)/kg of diet singly and in combination were characterized in male broiler chicks from 1 to 19 d of age. Body weights were depressed by OA, DAS, and the OA-DAS combination. There was a significant antagonistic interaction between OA and DAS for uric acid and cholesterol. The efficiency of feed utilization was reduced by DAS alone and by the OA-DAS combination. When compared with controls, additive toxicity was exhibited for reduced efficiency of feed utilization, increased relative weights of the liver and gizzard, and decreased concentration of serum total protein, mean corpuscular volume, and mean corpuscular hemoglobin. All chicks were scored for oral lesions using a scale of 1 to 4 (0 = no visible lesions; 3 = severe lesions). Oral lesions (average score = 2.6) were present in over 90% of the chicks receiving the DAS diet with or without OA. These data demonstrate that both OA and DAS alone and the OA-DAS combination can adversely affect broiler performance and health.
authors.affiliation: USDA, Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, Texas 77845.
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: T S
authors.initials: TS
authors.lastname: Edrington
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000097:blood; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D008297:Male; D009793:Ochratoxins / Q000008:administration & dosage / Q000009:adverse effects*; D009929:Organ Size / Q000187:drug effects; D014255:Trichothecenes / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D009793:Ochratoxins; D014255:Trichothecenes; C001809:diacetoxyscirpenol