title: Atrial natriuretic peptide response is blunted in patients with acute myocardial infarction and mild left ventricular dysfunction.
abstract: Neurohumoral parameters in 45 asymptomatic patients with acute myocardial infarction were measured. In patients with mild left ventricular dysfunction (ejection fraction < or = 45% and/or left ventricular end-diastolic pressure > or = 15 mm Hg), atrial natriuretic peptide levels differed significantly from those in patients with normal left ventricular function (127 +/- 74 pg/ml vs. 79 +/- 71 pg/ml; p < 0.001). After stimulus an increase in atrial natriuretic peptide levels (79 +/- 71 to 118 +/- 86 pg/ml; p < 0.001) was found only in patients with normal hemodynamic parameters. These data show that in patients with left ventricular dysfunction, the atrial natriuretic system is activated; however, atrial natriuretic peptide response to stimulus is present only in patients with normal hemodynamics.
authors.affiliation: Cardiology Division, EO Ospedali Galliera, Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Derchi
authors.forename: P
authors.initials: P
authors.lastname: Bellone
authors.forename: G
authors.initials: G
authors.lastname: Tommasini
authors.forename: M L
authors.initials: ML
authors.lastname: Biorci
authors.forename: M
authors.initials: M
authors.lastname: Randazzo
authors.forename: P
authors.initials: P
authors.lastname: Primarolo
authors.forename: C
authors.initials: C
authors.lastname: Vecchio
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D002303:Cardiac Output, Low / Q000503:physiopathology*; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin