Transient localization of 5-HT1A receptors in human cerebellum during development.
The appearance and distribution of 5-HT1A receptors in the human cerebellum during the ontogenetic development was studied in samples from a group of fetal, neonatal and adult cases, by means of quantitative autoradiography and membrane binding. [3H]8-OH-DPAT was used as a ligand. High densities of 5-HT1A receptors were found during the fetal and neonatal stages over the whole cerebellar cortex, with a slight predominance in the external part, in a band which included the molecular layer. In contrast, the adult cerebellum was nearly devoid of such sites. This finding supports a role for 5-HT1A receptors in the regulation of development in the human cerebellum.
del Olmo
E
E
Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain.
Díaz
A
A
Guirao-Piñeyro
M
M
del Arco
C
C
Pascual
J
J
Pazos
A
A
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D001345:Autoradiography; D002462:Cell Membrane / Q000378:metabolism; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism*; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D011985:Receptors, Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin