title: Functional properties of non-muscle tropomyosin isoforms.
abstract: Tropomyosins are a family of actin filament binding proteins. They have been identified in many organisms, including yeast, nematodes, Drosophila, birds and mammals. In metazoans, different forms of tropomyosin are characteristic of specific cell types. Most non-muscle cells, such as fibroblasts, express five to eight isoforms of tropomyosins. The various isoforms exhibit distinct biochemical properties that appear to be required for specific cellular functions.
authors.affiliation: Cold Spring Harbor Laboratory.
authors.forename: M F
authors.initials: MF
authors.lastname: Pittenger
authors.forename: J A
authors.initials: JA
authors.lastname: Kazzaz
authors.forename: D M
authors.initials: DM
authors.lastname: Helfman
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D005796:Genes; D006801:Humans; D009132:Muscles / Q000502:physiology; D009928:Organ Specificity; D011485:Protein Binding; D051381:Rats; D014335:Tropomyosin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; D014335:Tropomyosin