Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia.
We report the results of a linkage study in 24 families multiply affected with schizophrenia using a polymorphic DNA sequence encoding the third cytoplasmic loop of the dopamine D4 receptor. Two-point LOD score analyses with a range of single gene models ranging from near dominant to near recessive revealed no evidence for linkage. In addition, we examined the data by non-parametric sib-pair analysis and found no excess sharing of alleles between affected sib-pairs. We therefore conclude that mutations within the dopamine D4 receptor gene do not have a major aetiological role in schizophrenia in our collection of pedigrees.
Shaikh
S
S
Department of Neuropathology, Institute of Psychiatry, London, England.
Gill
M
M
Owen
M
M
Asherson
P
P
McGuffin
P
P
Nanko
S
S
Murray
R M
RM
Collier
D A
DA
D000483:Alleles; D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11; D017931:DNA Primers; D005192:Family Health; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D012091:Repetitive Sequences, Nucleic Acid; D012559:Schizophrenia / Q000235:genetics*
D017931:DNA Primers; C493599:DRD4 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4