[Effect of ATP infusion on heart function in the post-perfusion period after aortocoronary bypass surgery in patients with chronic ischemic heart disease].
Using thermodilution technique, 110 patients have been examined during aortocoronary bypass surgery. Cardiac output, pump coefficient, cardiac index, stroke index, mean and edge pulmonary pressure, and other parameters of peripheral hemodynamics have been determined. At the end of the operation upon heart function recovery the test patients were administered intravenously a 1% ATP solution at a dose of 0.05 and 0.025 mg/kg/min. In control patients inotropic drugs were not used, cardiac function recovered spontaneously. A thorough clinical analysis of central hemodynamic data in the control and test groups has been performed. A number of positive effects of intravenous 1% ATP solution in the postperfusion period have been revealed. The data obtained indicate that myocardium protection during heart arrest is insufficient and an additional administration of substrates that form energy and recover adequate coronary flow and oxygen consumption is necessary upon heart function recovery in all the cases. The first results of intravenous ATP administration make it possible to consider the above technique absolutely safe and especially useful for the improvement fo some central hemodynamic parameters.
Darbinian
T M
TM
Chernikov
V S
VS
Apasov
K T
KT
Vlasov
G P
GP
Garsevanov
G
G
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000328:Adult; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery*
D000255:Adenosine Triphosphate
Vliianie infuzii ATF na funktsii serdtsa v postperfuzionnom periode pri aortokoronarnom shuntirovanii u bol'nykh khronicheskoĭ ischemicheskoĭ bolezn'iu serdtsa.