[The effect of thyroliberin microinjections into the area of the nucleus tractus solitarii on respiratory and circulatory indices].
The TRH administration induced an increase in ventilation, essential changes in breathing pattern and activity of the inspiratory muscles in anesthetised rats. The doses 10(-12)-10(-8) M TRH decreased the heart rate, whereas 10(-10) M TRH increased the blood pressure. The data obtained suggest an important role of the nucleus tractus solitarii in realization of the TRH respiratory and circulatory effects. The data obtained corroborate the hypothesis of the participation of endogenous TRH in the respiratory and circulatory control.
Iniushkin
A N
AN
Merkulova
N A
NA
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D008845:Microinjections / Q000379:methods; D051381:Rats; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012132:Respiratory Muscles / Q000187:drug effects / Q000502:physiology; D017552:Solitary Nucleus / Q000187:drug effects* / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage*
D013973:Thyrotropin-Releasing Hormone
Vliianie mikroin''ektsiĭ tiroliberina v oblast' iadra solitarnogo trakta na pokazateli dykhaniia i krovoobrashcheniia.