Inhibition of tumour promotion by various palm-oil tocotrienols.
Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. The results reveal that gamma- and delta-tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). However, alpha- and gamma-tocopherols and dimers of gamma-tocotrienol or gamma-tocopherol lack this activity.
Goh
S H
SH
Department of Chemistry, University of Malaya, Kuala Lumpur.
Hew
N F
NF
Norhanom
A W
AW
Yadav
M
M
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000956:Antigens, Viral / Q000502:physiology; D002087:Butyrates; D020148:Butyric Acid; D002472:Cell Transformation, Viral / Q000187:drug effects; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000382:microbiology; D009369:Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D000073878:Palm Oil; D010938:Plant Oils / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D002087:Butyrates; C033305:Epstein-Barr virus early antigen; D010938:Plant Oils; D020148:Butyric Acid; D014810:Vitamin E; D000073878:Palm Oil; D013755:Tetradecanoylphorbol Acetate