Rapid eye movement sleep disturbance in posttraumatic stress disorder.
The subjective sleep disturbance in posttraumatic stress disorder (PTSD), including the repetitive, stereotypical anxiety dream, suggests dysfunctional rapid eye movement (REM) sleep mechanisms. The polysomnograms of a group of physically healthy combat veterans with current PTSD were compared with those of an age-appropriate normal control group. Tonic and phasic REM sleep measures in the PTSD subjects were elevated on the second night of recorded sleep. Increased phasic REM sleep activity persisted in the PTSD group on the subsequent night. During the study, an anxiety dream occurred in a PTSD subject in REM sleep. The results are consistent with the view that a dysregulation of the REM sleep control system, particularly phasic event generation, may be involved in the pathogenesis of PTSD. The finding of a specific disturbance of sleep unique to PTSD may have significant implications for the design of effective treatments for PTSD.
Ross
R J
RJ
Research Service, Philadelphia Veterans Affairs Medical Center, PA 19104.
Ball
W A
WA
Dinges
D F
DF
Kribbs
N B
NB
Morrison
A R
AR
Silver
S M
SM
Mulvaney
F D
FD
D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000523:psychology; D001143:Arousal / Q000187:drug effects; D003130:Combat Disorders / Q000175:diagnosis* / Q000523:psychology; D004325:Dreams / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000187:drug effects; D011619:Psychotropic Drugs; D012894:Sleep Stages / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000175:diagnosis* / Q000523:psychology; D012895:Sleep, REM / Q000187:drug effects; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology; D014728:Veterans / Q000523:psychology*
D011619:Psychotropic Drugs