An unusual reaction to alpha interferon in a case of non Hodgkin's lymphoma.
A 64-year-old man suffering from non Hodgkin's lymphoma in progression and resistant to conventional chemotherapy was treated with alpha interferon. In a few days he developed an unusual adverse reaction characterized by severe dermatological and neuromuscular toxicity. We describe the case and suggest a possible pathogenetic mechanism for this rare event.
Miglino
M
M
Department of Internal Medicine, University of Genova.
Pierri
I
I
Canepa
L
L
Carrara
P
P
Celesti
L
L
Gobbi
M
M
D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D010146:Pain / Q000139:chemically induced; D011994:Recombinant Proteins
D007370:Interferon Type I; D011994:Recombinant Proteins