title: In-vitro activity of five beta-lactam/beta-lactamase inhibitor combinations against consecutive isolates of the Enterobacteriaceae and Pseudomonas aeruginosa.
abstract: Susceptibility tests were performed on 2402 of consecutive isolates of Enterobacteriaceae and 254 strains of Pseudomonas aeruginosa in five separate medical centres. Five beta-lactams were evaluated with and without a beta-lactamase inhibitor. The effect of different inhibitors was species specific and the rank order of decreasing efficacy against all enteric bacilli was: cefoperazone-sulbactam > piperacillin-tazobactam > cefoperazone > ticarcillin-clavulanic acid > piperacillin > co-amoxiclav > ampicillin-sulbactam > ticarcillin > ampicillin > amoxycillin.
authors.affiliation: University of New Mexico Medical Center, Albuquerque 87106.
authors.forename: J C
authors.initials: JC
authors.lastname: McLaughlin
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
authors.forename: E H
authors.initials: EH
authors.lastname: Gerlach
authors.forename: D J
authors.initials: DJ
authors.lastname: Hardy
authors.forename: M A
authors.initials: MA
authors.lastname: Pfaller
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013045:Species Specificity; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams