Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp.
Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.
Shu
Y Z
YZ
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492.
Huang
S
S
Wang
R R
RR
Lam
K S
KS
Klohr
S E
SE
Volk
K J
KJ
Pirnik
D M
DM
Wells
J S
JS
Fernandes
P B
PB
Patel
P S
PS
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D011090:Polyenes; C087124:manumycin E; C087126:manumycin G; C087125:manumycin F