A new system for recording electroretinographical potentials in animals.
Electroretinography can provide meaningful evidence of oculotoxic changes. We describe a new recording system specially constructed for animal experiments. It meets the standards for electroretinographical investigations and recording systems set up by international committees. The recording apparatus has a resolution of 0.49 microV (amplitude) and 1 ms with a sensitivity range of +/- 1 mV full scale and a band-pass of 0.03 to 1,000 Hz. The signals are digitized and processed by a computer. The calibration symbol is faithfully represented as a rectangular impulse with an amplitude of 100 microV and a period of 100 ms. Normal values were calculated for 25-week-old albino Wistar rats. The normal range is defined as the mean +/- 2 SD for A and B wave parameters. These normal values can serve as reference values for future studies in oculotoxicity.
Bredehorn
T
T
Department of Ophthalmology, University of Kiel, FRG.
Duncker
G
G
Kuper
H
H
Papst
N
N
D000818:Animals; D003623:Dark Adaptation; D004566:Electrodes; D004596:Electroretinography / Q000295:instrumentation / Q000379:methods*; D005260:Female; D008564:Membrane Potentials / Q000502:physiology; D008838:Microcomputers; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012160:Retina / Q000502:physiology*; D012680:Sensitivity and Specificity