title: Salivary anti-RSV IgA antibodies and respiratory infections during the first year of life in atopic and non-atopic infants.
abstract: Salivary SIgA antibodies against RS virus were studied in 105 children during the first year of life. The infants were divided into groups according to their risk of atopy. At birth 13 neonates showed measurable amounts of SIgA to RS virus. In another 26 children specific antibodies were detected but in concentrations too low for quantitative analysis. During the first year of life this increased to 29 antibody-positive samples with measurable amounts of antibody and 39 with concentrations too low for quantitative determination. At this time 8 children of the high risk group had developed symptoms of allergy. None of these children had measurable amounts of SIgA anti-RSV in their saliva. In comparison, 10 of the remaining 26 high risk infants without symptoms of allergy did have such antibodies. Atopic infants had significantly more respiratory infections during the first year of life than nonatopic infants. The avidity of SIgA anti-RSV in neonatal samples was significantly higher than avidity determined in breast milk SIgA but comparable to the avidity of serum IgG. During the first year of life a continuing decrease of salivary SIgA avidity was observed.
authors.affiliation: Children's Hospital, Philipps University, Marburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Banzhoff
authors.forename: A
authors.initials: A
authors.lastname: Dulleck
authors.forename: S
authors.initials: S
authors.lastname: Petzoldt
authors.forename: C H
authors.initials: CH
authors.lastname: Rieger
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D000915:Antibody Affinity; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000382:microbiology; D012463:Saliva / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007073:Immunoglobulin E