title: Prenylated proteins in regenerating rat liver.
abstract: During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylgeranylated proteins in pre-S phase is confirmed by an increased level of lamin A, B, C and of several GTP-binding proteins. These results suggest a relevance of both farnesylation and geranylgeranylation in this phase of the cell cycle.
authors.affiliation: Dipartimento di Biologia Cellulare e dello Sviluppo, Università La Sapienza, Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bruscalupi
authors.forename: F
authors.initials: F
authors.lastname: Castellano
authors.forename: S
authors.initials: S
authors.lastname: Sacco
authors.forename: A
authors.initials: A
authors.lastname: Trentalance
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D034904:Lamin Type A; D034882:Lamins; D008115:Liver Regeneration; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism; D017368:Protein Prenylation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D034904:Lamin Type A; D034882:Lamins; D009687:Nuclear Proteins; D011506:Proteins; D019204:GTP-Binding Proteins; D016283:Proto-Oncogene Proteins p21(ras)