title: Tissue lipid quantification using narrow bandwidth magnetic resonance imaging with a presaturation pulse.
abstract: OBJECTIVE
  Chemical-shift artifact occurs within tissues when band-like presaturation pulses are applied perpendicular to the frequency-encoding axis in narrow band-width magnetic resonance imaging. This phenomenon was used to quantify the lipid fraction in phantoms used to simulate tissue.
  
  
  METHODS
  Twenty phantoms with various lipid/water ratios were imaged on spin-echo sequence (repetition time/echo time, 2,000/20 msec) using a 1.5-T magnet. A narrow bandwidth that caused 6-mm chemical shift and a presaturation pulse 6-mm in width were used in the imagining. The lipid fraction values calculated from the resulting images were compared with values determined by a spectrometer.
  
  
  RESULTS
  The image-derived values (LI) correlated strongly with the values determined by spectrometry (LS) (LI = 0.97 + 0.99 LS, r = .998).
  
  
  CONCLUSIONS
  Chemical-shift artifact around the presaturation-applied areas should provide a simple and efficient method for the accurate quantification of tissue lipid fractions.
authors.affiliation: Department of Diagnostic Radiology, Gunma University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishizaka
authors.forename: K
authors.initials: K
authors.lastname: Tomiyoshi
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Inoue
mesh_terms: D016477:Artifacts; D006801:Humans; D008055:Lipids; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008961:Models, Structural
chemical_list: D008055:Lipids