[Expanded nuclear magnetic resonance studies in Borna disease virus seropositive psychiatric patients and control probands].
There is growing evidence, that Borna Disease virus (BDV) or a variant may cause neuropsychiatric disorders in humans. The presence of specific BDV serum antibodies indicates an earlier contact with BDV. Earlier MRI results showing a raised prevalence of white matter lesions in BDV-seropositive psychiatric patients, possibly indicating encephalitic lesions, are not confirmed in this extended study, however in BDV-seropositive psychiatric patients the occurrence of cerebral atrophy seems to be more frequent, a finding compatible with hydrocephalus e vacuo found in animals after BDV-encephalitis. Because encephalitic lesions in BD are predominantly found in the gray matter of the brain, which is hardly visualized by MRI, the failure to detect lesions in BDV-seropositive patients could be due to methodological problems.
Bechter
K
K
Abteilung Psychiatrie II, Universität Ulm.
Bauer
M
M
Estler
H C
HC
Herzog
S
S
Schüttler
R
R
Rott
R
R
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D001284:Atrophy; D001890:Borna Disease / Q000175:diagnosis* / Q000276:immunology / Q000523:psychology; D001891:Borna disease virus / Q000276:immunology*; D001921:Brain / Q000473:pathology; D004660:Encephalitis / Q000175:diagnosis* / Q000276:immunology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000276:immunology / Q000523:psychology
D000914:Antibodies, Viral
Erweiterte kernspintomographische Untersuchungen bei Borna-disease-Virus -seropositiven psychiatrischen Patienten und Kontrollen.