Reduced sensitivity of tuberculosis serodiagnosis in patients with AIDS in Uganda.
METHODS
The diagnostic utility of serodiagnosis of tuberculosis in HIV-infected persons was studied in Kampala, Uganda.


OBJECTIVE
This study was undertaken to evaluate the utility of a recently described serologic assay for the diagnosis of tuberculosis in HIV-infected patients.


METHODS
The study was undertaken as a cross-sectional survey of 349 subjects, including human immunodeficiency virus-infected and uninfected patients with tuberculosis and control subjects. Serum from each subject was assayed by enzyme-linked immunosorbent assay (ELISA) for IgG antibody to the 30,000 dalton antigen of Mycobacterium tuberculosis.


RESULTS
Test sensitivity dropped from 0.62 in non HIV-infected tuberculous patients to 0.28 in HIV-infected patients.


CONCLUSIONS
ELISA serodiagnosis of tuberculosis may have a markedly decreased utility in populations where HIV infection is prevalent.
Daniel
T M
TM
Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4978.
Sippola
A A
AA
Okwera
A
A
Kabengera
S
S
Hatanga
E
E
Aisu
T
T
Nyole
S
S
Byekwaso
F
F
Vjecha
M
M
Ferguson
L E
LE
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000907:Antibodies, Bacterial / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014376:Tuberculosis / Q000175:diagnosis*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G