title: A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22.
abstract: The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.
authors.affiliation: Paediatric Research Unit, United Medical School, London, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Vetrie
authors.forename: E
authors.initials: E
authors.lastname: Kendall
authors.forename: A
authors.initials: A
authors.lastname: Coffey
authors.forename: S
authors.initials: S
authors.lastname: Hassock
authors.forename: J
authors.initials: J
authors.lastname: Collins
authors.forename: C
authors.initials: C
authors.lastname: Todd
authors.forename: H
authors.initials: H
authors.lastname: Lehrach
authors.forename: M
authors.initials: M
authors.lastname: Bobrow
authors.forename: D R
authors.initials: DR
authors.lastname: Bentley
authors.forename: A
authors.initials: A
authors.lastname: Harris
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics; D016386:Chromosome Walking; D018244:Chromosomes, Artificial, Yeast; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000235:genetics; D000795:Fabry Disease / Q000235:genetics; D015723:Gene Library; D005819:Genetic Markers; D006801:Humans; D014960:X Chromosome
chemical_list: D005819:Genetic Markers