Susceptibility to desferrioxamines and other chelators of coagulase-negative staphylococci.
A total of 233 staphylococci and micrococci belonging to 17 species were tested for their susceptibility to desferrioxamines B, G and E, respectively. Using an agar diffusion method on iron poor media, all of the S. epidermidis, 12 out of 22 S. hominis and 5 out of 22 S. capitis strains were susceptible to desferrioxamines. Among the S. capitis strains tested, two of them were susceptible to desferrioxamine E and resistant to desferrioxamines B and G. All other staphylococci and micrococci tested were resistant to desferrioxamines B, G and E. Different susceptibility to 5 mM ethylenediaminedi-(o-phenylacetic acid) as an artificial chelator demonstrated the existence of additional iron-supplying systems in staphylococci and micrococci.
Heuck
D
D
Robert Koch Institute of the Federal Health Office, Wernigerode, Germany.
Witte
W
W
Braulke
C
C
Reissbrodt
R
R
D002614:Chelating Agents / Q000494:pharmacology*; D003030:Coagulase / Q000032:analysis; D003676:Deferoxamine / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects* / Q000201:enzymology; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000201:enzymology
D002614:Chelating Agents; D003030:Coagulase; D007501:Iron; D003676:Deferoxamine