Rat FGF receptor-4 mRNA in the brain is expressed preferentially in the medial habenular nucleus.
The fibroblast growth factor (FGF) receptor family consists of four members, FGFR-1, FGFR-2, FGFR-3 and FGFR-4, that are closely related receptor tyrosine kinases. We examined the expression of rat FGFR-4 mRNA in the brain by in situ hybridization and compared it with that of the mRNAs for other FGF receptors. In contrast with FGFR-1, FGFR-2 and FGFR-3 mRNAs which are expressed widely in the brain, the FGFR-4 mRNA in the brain is expressed preferentially in the medial habenular nucleus neurons. The present finding indicates that FGFR-4 has a function specific to the medial habenular nucleus.
Itoh
N
N
Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
Yazaki
N
N
Tagashira
S
S
Miyake
A
A
Ozaki
K
K
Minami
M
M
Satoh
M
M
Ohta
M
M
Kawasaki
T
T
D000818:Animals; D002552:Cerebral Ventricles / Q000737:chemistry*; D005346:Fibroblast Growth Factors; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D051499:Receptor, Fibroblast Growth Factor, Type 4; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*
D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; C496373:Fgfr4 protein, rat; D051499:Receptor, Fibroblast Growth Factor, Type 4