Identification and semi-quantification of estrogen and progesterone receptors in peripheral giant cell lesions of the jaws.
Cases of peripheral giant cell lesions of the jaws (PGCL) were evaluated for the detection of estrogen and progesterone receptor proteins (ERS/PRS) utilizing immunoperoxidase staining. Staining for ERS was strongly positive in three cases when examining the mononuclear cell population. Another two cases were weakly positive. In addition, an occasional ER + multinucleated giant cell could be observed in three of the cases examined. PRS immunoreactivity was essentially negative in all cases. It is well known that the PGCL has a marked female predilection. This, coupled with the present findings, gives further evidence that some PGCL may be at least partially under hormonal influence.
Whitaker
S B
SB
Department of Oral Diagnosis and Patient Services, School of Dentistry, Medical College of Georgia, Augusta.
Bouquot
J E
JE
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006101:Granuloma, Giant Cell / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007571:Jaw Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012737:Sex Factors
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone