title: Ultrasound determination of total arterial wall thickness.
abstract: OBJECTIVE
  Ultrasonic measurement techniques for determining intima-media thickness and total arterial wall thickness have been described. The intima-media thickness measurements are currently in use in large epidemiologic trials. Intima-media thickness does not evaluate extramedial atherosclerotic change and so may not fully reflect pathologic changes in the arterial wall.
  
  
  METHODS
  After we performed variability studies of B-mode image acquisition and measurement, we measured total wall thickness and intima-media thickness of the common carotid arteries in 60 adult subjects in three groups: a control group aged 20 to 29 years, a control group aged 60 to 79 years, and a claudication group aged 60 to 79 years. Measurements were made with B-mode ultrasound images.
  
  
  RESULTS
  No statistical difference between sexes was noted. A statistically significant (p < or = 0.05) increase in intima-media thickness and wall thickness was found with increasing age, and an additional increase was observed with clinically significant lower extremity arterial occlusive disease (p < or = 0.05). Image quality had an effect on measurement accuracy.
  
  
  CONCLUSIONS
  The finding that the wall thickness of common carotid arteries is increased in those patients with clinically significant lower extremity disease supports the theory that atherosclerosis affects the arterial wall in a systemic fashion. Because intima-media thickness also increases across subject groups without change in its proportional contribution to the total arterial wall thickness, extramedial arterial changes also occur with aging and the development of atherosclerosis. We propose that because increases in wall thickness measurements of common carotid arteries follow intima-media thickness increase (but do not necessarily measure the same physiologic change) and the wall thickness method can be used in cases when the intima-media thickness cannot be measured, arterial wall thickness measurement may serve as an alternate or confirmatory test of peripheral artery atherosclerotic severity.
authors.affiliation: Department of Surgery, University of Washington Medical Center, Seattle.
authors.forename: T C
authors.initials: TC
authors.lastname: Hodges
authors.forename: P R
authors.initials: PR
authors.lastname: Detmer
authors.forename: D L
authors.initials: DL
authors.lastname: Dawson
authors.forename: R O
authors.initials: RO
authors.lastname: Bergelin
authors.forename: K W
authors.initials: KW
authors.lastname: Beach
authors.forename: T S
authors.initials: TS
authors.lastname: Hatsukami
authors.forename: B K
authors.initials: BK
authors.lastname: Zierler
authors.forename: J A
authors.initials: JA
authors.lastname: Isaacson
authors.forename: D E
authors.initials: DE
authors.lastname: Strandness
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000465:Algorithms; D001161:Arteriosclerosis / Q000000981:diagnostic imaging; D017536:Carotid Artery, Common / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007383:Intermittent Claudication / Q000000981:diagnostic imaging; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D017540:Tunica Media / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods