Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats.
We examined the gene expression of angiotensin AT1A receptors in aortic endothelial cells of cyclosporine induced hypertensive rats using reverse transcribed polymerase chain reaction method. The gene expression of angiotensin AT1A receptors in aortic endothelial cells of cyclosporine induced hypertensive rats showed a two-fold increase when compared with that in normotensive control rats. These results raise a possibility that the up-regulation of endothelial angiotensin AT1A receptors participates in the pathogenesis of cyclosporine induced hypertension.
Iwai
J
J
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Kanayama
Y
Y
Inoue
N N
NN
Okamura
M
M
Takeda
T
T
D000803:Angiotensin I; D000818:Animals; D001013:Aorta, Thoracic; D001483:Base Sequence; D016572:Cyclosporine / Q000633:toxicity*; D017931:DNA Primers / Q000737:chemistry; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D017207:Rats, Sprague-Dawley; D011945:Receptors, Angiotensin / Q000235:genetics*; D015854:Up-Regulation
D017931:DNA Primers; D011945:Receptors, Angiotensin; D016572:Cyclosporine; D000803:Angiotensin I