Serologic HLA typing in cryptogenic Lennox-Gastaut syndrome.
Serologic HLA typing was performed on 12 patients with cryptogenic Lennox-Gastaut syndrome and compared to a normal control group of 1661 Caucasians. In the Lennox-Gastaut group we found a significant increase in the frequency of DR5 antigen (55%, chi 2 = 5.6), and an indication of a decrease in the frequency of DR4 antigen (0%, chi 2 = 3.0) as compared with controls (20% and 28%, respectively). No significant differences existed in the frequencies of HLA-A, B, and C antigens between the Lennox-Gastaut group and the controls. These findings contribute to the hypothesis that immunogenetic mechanisms may play a role in triggering or maintaining cryptogenic Lennox-Gastaut syndrome.
van Engelen
B G
BG
Institute of Neurology, University Hospital Nijmegen, The Netherlands.
de Waal
L P
LP
Weemaes
C M
CM
Renier
W O
WO
D002648:Child; D004827:Epilepsy / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015804:HLA-DR4 Antigen / Q000032:analysis; D015805:HLA-DR5 Antigen / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D013577:Syndrome
D006680:HLA Antigens; D015804:HLA-DR4 Antigen; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II