Reduced toxicity of a new formulation--peplomycin adsorbed on activated carbon particles--in mice.
We studied the acute toxicity and pathological effects of peplomycin adsorbed on fine activated carbon particles (PEP-CH) injected subcutaneously in mice. The 50% lethal dose value was 41.2 mg/kg in terms of peplomycin, which was 1.52 times that of the peplomycin aqueous solution (PEP-AQ) of 27.1 mg/kg. Deaths occurred from 5 to 31 days after administration of PEP-CH and from 5 to 22 days after administration of PEP-AQ solution. These figures are remarkably different from another report in which the mice given PEP-AQ died within 10 days.
Hagiwara
A
A
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Sawai
K
K
Shoubayashi
S
S
Sakakura
C
C
Muranishi
S
S
D000327:Adsorption; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002244:Carbon; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D017663:Peplomycin / Q000008:administration & dosage / Q000633:toxicity*; D013535:Suspensions
D013535:Suspensions; D017663:Peplomycin; D002244:Carbon