Monocyte activity in the presence of calcium phosphate activated by 1,25 (OH)2 VD3 and interferon-gamma.
The monocyte is an essential element in cellular immunity. Consequently, its role in the biocompatibility process is important. A model study of the degradation of bioactive ceramics (calcium phosphate) using human peripheral blood monocytes activated by 1,25 (OH)2 VD3 and interferon (IFN)-gamma was implemented. Activated monocytes cultivated on calcium phosphate tablets led to cellular morphological modifications and to changes in the number of nuclei (from d 2 to 14). IFN-gamma promoted adhesion, the appearance of cytoplasmic extensions and multinuclei. Cavity resorption activity on the material was observed simultaneously.
Benahmed
M
M
Laboratoire de Recherche sur les Matériaux d'Intérêt Biologique CNRS, Faculté de Chirurgie Dentaire, Nantes University, France.
Blottiere
H
H
Praloran
V
V
Daculsi
G
G
D001672:Biocompatible Materials; D002117:Calcitriol / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002478:Cells, Cultured; D002516:Ceramics; D004347:Drug Interactions; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D007371:Interferon-gamma; D002117:Calcitriol