Aminoglycoside nephrotoxicity following single-dose cystoscopy prophylaxis.
OBJECTIVE
To report a case of gentamicin-associated acute tubular necrosis following single-dose exposure.


METHODS
Central-city, university-affiliated teaching hospital.


METHODS
An 82-year-old man, admitted for evaluation of shortness of breath, appetite reduction with weight loss, and stable renal insufficiency, developed urinary retention, which prompted a urologic evaluation followed by a cystoscopy.


METHODS
A single 1.6-mg/kg (actual body weight) dose of gentamicin was administered as prophylaxis prior to this procedure.


RESULTS
A significant decline in renal function was observed 48 hours following gentamicin administration. A nephrology evaluation excluded pre- and postrenal causes and attributed this episode of nonoliguric acute tubular necrosis to a single dose of gentamicin.


CONCLUSIONS
Although not consistent with currently proposed mechanisms and reported onset of aminoglycoside-induced nephrotoxicity, an etiology other than that concluded by this case report appears unlikely.
Weir
B A
BA
Department of Pharmacy, Sinai Samaritan Medical Center, Milwaukee, WI 53233.
Mazumdar
D C
DC
D000368:Aged; D000369:Aged, 80 and over; D003558:Cystoscopy; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008297:Male; D011292:Premedication
D005839:Gentamicins