[The antioxidant action of AH-9].
AH-9 is a compound with hypoglycemic action. AH-9 was also found to have antioxidant activity. The hemolysis, hemoglobin oxidation and lipid peroxidation of erythrocytes induced by hydrogen peroxide and Fe(++)-induced MDA formation of liver microsomes were inhibited by AH-9, and the activity of SOD and catalase were shown to be increased in normal and alloxan-diabetic mice after treatment with AH-9. The above results indicate that AH-9 might act as a scavenger of superoxide and might be useful for improving the pathophysiological state in diabetes mellitus and its complications.
Jiang
Z
Z
Institute of Materia Medica, CAMS and PUMC, Beijing.
Xie
M
M
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology; D004910:Erythrocyte Membrane / Q000187:drug effects; D006834:Hydrazines / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D006834:Hydrazines; D007004:Hypoglycemic Agents; C087065:AH 9; D002374:Catalase; D013482:Superoxide Dismutase