title: Insulin like growth factor 1 receptor signal transduction to the nucleus.
abstract: The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.
authors.affiliation: Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston 29425.
authors.forename: S A
authors.initials: SA
authors.lastname: Rosenzweig
authors.forename: B S
authors.initials: BS
authors.lastname: Oemar
authors.forename: N M
authors.initials: NM
authors.lastname: Law
authors.forename: U T
authors.initials: UT
authors.lastname: Shankavaram
authors.forename: B S
authors.initials: BS
authors.lastname: Miller
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D005786:Gene Expression Regulation; D005920:Glomerular Mesangium / Q000378:metabolism; D006801:Humans; D010766:Phosphorylation; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis / Q000502:physiology*; D011972:Receptor, Insulin / Q000096:biosynthesis; D015398:Signal Transduction
chemical_list: D016755:Proto-Oncogene Proteins c-jun; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin