The effect of interleukin-1 on the thyroid gland.
The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.
Rasmussen
A K
AK
Medical department P, State University Hospital, Copenhagen, Denmark.
Feldt-Rasmussen
U
U
Bendtzen
K
K
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000096:biosynthesis; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis; D007515:Islets of Langerhans / Q000187:drug effects; D008297:Male; D051379:Mice; D010902:Pituitary Gland / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects*; D013967:Thyroiditis, Autoimmune / Q000503:physiopathology
D007375:Interleukin-1; D015850:Interleukin-6; D011994:Recombinant Proteins; D000242:Cyclic AMP