[Role of lipid peroxidation in liver damage in visceral-ischemic shock].
The authors examined the contribution of lipid peroxidation (LPO) in the pathogenesis of hepatic damage in visceral and ischemic shock (VIS) induced by upper mesenteric artery occlusion followed by stepwise revascularization. There was generation of initial and terminal PLO products in hepatic tissue, which increased as VIS and toxemia progressed. The accumulation kinetics of thiobarbituric acid-positive agents in the hepatic homogenates, microsomes, and mitochondria isolated in different periods of VIS was studied. The findings confirm the hypothesis that oxygen radicals play a role in the development of disturbances typical of those in the liver during the shock.
Shneĭvas
V B
VB
Amilov
K S
KS
Levin
G S
GS
D000818:Animals; D007511:Ischemia / Q000150:complications / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008107:Liver Diseases / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D012769:Shock / Q000150:complications / Q000503:physiopathology*; D014781:Viscera / Q000098:blood supply*
Rol' perekisnogo okisleniia lipidov v povrezhdenii pecheni pri vistseral'no-ishemicheskom shoke.