title: Pustular eruption after drug exposure: is it pustular psoriasis or a pustular drug eruption?
abstract: Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding drug exposure, and rapid disappearance of the eruption after the drug is stopped, suggest a drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following drug administration. The history of preceding drug exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were drug-induced.
authors.affiliation: Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York.
authors.forename: J M
authors.initials: JM
authors.lastname: Spencer
authors.forename: D N
authors.initials: DN
authors.lastname: Silvers
authors.forename: M E
authors.initials: ME
authors.lastname: Grossman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002440:Cefoxitin / Q000009:adverse effects; D002506:Cephalexin / Q000009:adverse effects; D015377:Cilastatin / Q000009:adverse effects; D000077728:Cilastatin, Imipenem Drug Combination; D003937:Diagnosis, Differential; D004338:Drug Combinations; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D015378:Imipenem / Q000009:adverse effects; D008297:Male; D011565:Psoriasis / Q000175:diagnosis*; D012867:Skin / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015377:Cilastatin; D002440:Cefoxitin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination; D002506:Cephalexin