[Immunohistochemical study of chronic ulcerative colitis by use of monoclonal antibody Hb3 against human large bowel carcinoma].
Monoclonal antibody Hb3 against large bowel carcinoma was used to study 20 cases of large bowel carcinoma and 60 cases of chronic ulcerative colitis (CUC) by immunohistochemical methods.


RESULTS
The positive Hb3 binding rates to large bowel carcinoma, CUC, normal bowel mucosa and fetal large bowel mucosa were 80.0%, 41.7%, 8.3% and 100.0% respectively. In addition, the positive Hb3 binding rate to CUC in the rectum was higher than that in the colon, which agrees with the fact that most large bowel carcinomas are found in the rectum. The authors believe that the expression of tumor associated antigen in CUC is a very early biochemical abnormality which can be detected before morphological changes occur. The results of this study support the viewpoint that chronic ulcerative colitis is a precancerous condition of large bowel cancer.
Kuang
X W
XW
Institute of Oncology, Hengyang Medical College, Hunan.
D000230:Adenocarcinoma / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology*; D002648:Child; D003093:Colitis, Ulcerative / Q000276:immunology*; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology; D012004:Rectal Neoplasms / Q000276:immunology
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate