p53 expression in laryngeal carcinoma.
The expression of the nuclear phosphoprotein, p53, was studied in 21 cases of squamous cell carcinoma of the larynx and 16 benign laryngeal lesions using the polyclonal rabbit antibody, CM1 (Novocastra Laboratories Ltd). Fourteen of the carcinomas showed nuclear staining whereas only one of the benign lesions exhibited presence of the protein. This suggests that, as with squamous cell carcinoma of the lung, p53 plays a role in the development of malignant disease of the larynx.
Boag
G
G
Department of Anatomical Pathology, St Vincent's Hospital, Melbourne, Victoria.
Lee
C S
CS
Charalambous
D
D
Rode
J
J
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007818:Laryngeal Diseases / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53