Thiaproline reduces glomerular basement membrane thickness and collagen accumulation in the db/db mouse.
Glomerular basement membrane thickening and mesangial expansion are the main pathological features in diabetic nephropathy--glomerulosclerosis with the biochemical correlate of increased collagen accumulation. We studied a new principle to reduce collagen accumulation in the glomerulus: thiaproline, known to inhibit protein synthesis by blocking the elongation, led in our studies to a morphological reduction of the glomerular basement membrane thickening and to a decreased collagen content. As the thiaproline analogue is incorporated into collagen, the mechanism of increased degradation of the modified collagen is being discussed.
Lubec
B
B
Department of Pediatrics, University of Vienna, Austria.
Rokitansky
A
A
Hayde
M
M
Aufricht
C
C
Wagner
U
U
Mallinger
W R
WR
Höger
H
H
Lubec
G
G
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001485:Basement Membrane / Q000187:drug effects / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D007668:Kidney / Q000033:anatomy & histology / Q000378:metabolism; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D012995:Solubility; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
D000975:Antioxidants; D001786:Blood Glucose; D006595:Hexosamines; D013844:Thiazoles; D053778:Thiazolidines; D019270:Fructosamine; D003094:Collagen; C003438:thiazolidine-4-carboxylic acid