Production of prostanoids by Lewis rat Schwann cells in vitro.
Schwann cells may play a role in the pathogenesis of autoimmune inflammatory diseases of peripheral nerve. They are the targets of autoimmune attack but may also act as antigen presenting cells. Here we investigate the possibility that Schwann cells may be able to modulate T-cell mediated immunity via prostanoid production. The results show that Lewis rat Schwann cells in vitro generate significant amounts of the pro-inflammatory and immunoregulatory mediators, prostaglandin E2 and thromboxane A2 and so may influence autoimmune inflammatory reactions within the peripheral nervous system.
Constable
A L
AL
School of Biological Sciences, University of Sydney, NSW, Australia.
Armati
P J
PJ
Toyka
K V
KV
Hartung
H P
HP
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002478:Cells, Cultured; D015232:Dinoprostone / Q000096:biosynthesis*; D006207:Half-Life; D007371:Interferon-gamma / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D012583:Schwann Cells / Q000187:drug effects* / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D014409:Tumor Necrosis Factor-alpha; D000001:Calcimycin; D013929:Thromboxane B2; D013928:Thromboxane A2; D007371:Interferon-gamma; D015232:Dinoprostone; D013755:Tetradecanoylphorbol Acetate