title: [Clinicopathological study on choroid plexus tumors: immunohistochemical features and argyrophilic nucleolar organizer regions values].
abstract: Immunohistochemical features and numbers of argyrophilic nucleolar organizer regions (Ag-NORs) were investigated on 6 cases with choroid plexus tumors: 3 adult and one pediatric cases with choroid plexus papilloma (CPP) and 2 pediatric cases with choroid plexus carcinoma (CPC) clinicopathologically. One of the 2 children with CPC developed a recurrence with dissemination to the CSF and died 2 years postoperatively (case 6), while the other survived following surgery (case 5). This outcome suggested the existence of biological differences in these tumors. We conducted an immunohistochemical examination of prealbumin, S-100 protein, glial fibrillary acidic protein (GFAP), cytokeratin (CKER), and epithelial membrane antigen (EMA) using avidin-biotin complex (ABC) methods and the silver colloid staining technique for Ag-NORs. All 4 CPP were positive for prealbumin and S-100 protein, with 3 of them being strongly positive; 3 of 4 were positive for GFAP and 2 were positive for CKER and EMA. Two cases of CPC were weakly positive for prealbumin. However the part of reserved papillary structure of case 5 was strongly positive for it. The tumor of the survived child was positive for S-100, GFAP, CKER, while negative for EMA. A positivity for S-100 protein and prealbumin was associated with a good outcome, whereas that for GFAP, CKER, and EMA was not. The mean number of Ag-NORs in the 2 cases with CPC exceeded that in cases with CPP. Of the 2 cases with CPC, fetal one (case 6) showed a higher number of Ag-NORs than the survived patient.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Tokushima.
authors.forename: N
authors.initials: N
authors.lastname: Shirakawa
authors.forename: S
authors.initials: S
authors.lastname: Kannuki
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D016545:Choroid Plexus Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D010212:Papilloma / Q000175:diagnosis / Q000473:pathology; D011228:Prealbumin / Q000032:analysis; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis; D016622:Silver Staining
chemical_list: D014408:Biomarkers, Tumor; D011228:Prealbumin; D009418:S100 Proteins