Pharmacokinetics of albendazole in children with hydatid disease.
The pharmacokinetics of albendazole were investigated in five children who were hospitalized at the Kenyatta National Hospital for the treatment of hydatid disease. Unchanged albendazole was below detectable level in plasma. The major metabolite present was albendazole sulphoxide. In one of the patients, the concentration of albendazole sulphone in plasma was significantly high, whereas in the other four children, only trace amounts were detected. Maximum concentrations of albendazole sulphoxide in these five children were variable and generally higher than those reported in adults by other workers. Other pharmacokinetic parameters were comparable to those found in other studies.
Okelo
G B
GB
Ministry of Health, Nairobi.
Hagos
B
B
Ng'ang'a
J N
JN
Ogeto
J O
JO
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015766:Albendazole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D000871:Anthelmintics / Q000097:blood; D002648:Child; D016903:Drug Monitoring; D004443:Echinococcosis / Q000097:blood / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D013997:Time Factors
D000871:Anthelmintics; D015766:Albendazole; C027186:albendazole sulfoxide