The fundamental unit of synthetic melanin: a verification by tunneling microscopy of X-ray scattering results.
A characteristic dimension of a melanin protomolecule synthesized from tyrosine has been investigated by scanning tunneling microscopy (STM). Identification of a melanin protomolecule of approximately approximately 20 A lateral extent and approximately 10 A height has been established. This size is in good agreement with models constructed to fit wide angle X-ray diffraction experiments on melanin. These protomolecules are believed to consist of Van der Waals interacting stacks of a basic random polymer of 5.6 indolequinone units. There is extensive pi-delocalization within the individual polymeric sheets. Structure minimization and molecular orbital techniques were employed to verify the X-ray and STM results.
Zajac
G W
GW
Amoco Research Center, Amoco Corporation, Naperville, IL 60566-7011.
Gallas
J M
JM
Cheng
J
J
Eisner
M
M
Moss
S C
SC
Alvarado-Swaisgood
A E
AE
D008543:Melanins / Q000737:chemistry*; D016252:Microscopy, Scanning Tunneling; D008958:Models, Molecular; D014961:X-Ray Diffraction
D008543:Melanins