The Unp proto-oncogene encodes a nuclear protein.
The mouse Unp gene is related to TRE17, a human oncogene, but is not its mouse homolog. Unp is a ubiquitously expressed gene producing two related mRNAs. The protein product of Unp is localized in the nucleus. Expression of Unp from a highly active promoter results in tumorigenic transformation of NIH3T3 cells injected into athymic mice. Unp therefore encodes a novel nuclear oncoprotein.
Gupta
K
K
Department of Biochemistry, University of Ottawa, Canada.
Chevrette
M
M
Gray
D A
DA
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases
C000715470:MAS1 protein, human; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C082325:Usp4 protein, mouse; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases