[Hormonal regulation of carbohydrate metabolism in the liver in plague intoxication].
It was shown that "mouse" toxin of Yersinia pestis injected into the rat tail vein (LD100) caused a 2-fold decrease in the glycogen content in the liver and the glucose content in the blood. The Bmax of beta-adrenoceptors as well as basal, forskolin, 5-guanylyl imidodiphosphate, fluoride and glucagon-stimulated liver adenylate cyclase (AC) activities did not change in all periods of intoxication. After 5 hours of intoxication isoproterenol had no effect on AC; however, the cAMP content was increased 1.5 times in comparison with control. These data suggest that plague intoxication has no effect on cAMP-dependent regulation of glycogenolysis and gluconeogenesis in the liver. The action mechanism of toxin(s) on carbohydrate metabolism in also unrelated to the decrease in Bmax for alpha 1 adrenergic receptors in liver membranes, whose number increased 1.3 and 1.5 times after 1 and 2 hours of intoxication.
Cherkasova
T D
TD
Iurkiv
V A
VA
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D004789:Enzyme Activation; D005459:Fluorides / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D015010:Yersinia pestis / Q000378:metabolism*
D001427:Bacterial Toxins; D001786:Blood Glucose; D008112:Liver Glycogen; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D005576:Colforsin; D006165:Guanylyl Imidodiphosphate; D005934:Glucagon; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D005459:Fluorides
Gormonal'naia reguliatsiia uglevodnogo obmena v pecheni pri chumnoĭ intoksikatsii.