title: [Clinical study of fluconazole-injectable and -granules in pediatric patients].
abstract: In this study, we have investigated the clinical effectiveness of fluconazole (FLCZ) given intravenously or orally to pediatric patients with systemic fungal infections. FLCZ was administered intravenously to two patients with acute leukemia (multiple hepatosplenic candidiasis and aspergillosis) and orally to two mycosis complicated with neuroblastoma and aplastic anemia, respectively. Clinical efficacies were excellent and no side effects were observed in any patients. Pharmacokinetic analysis in 6 neonates revealed that the plasma half-life is 37-41 hours after administration of single dose of intravenous infusion of 3 mg/kg of FLCZ.
authors.affiliation: Department of Pediatrics, School of Medicine, Kanazawa University.
authors.forename: H
authors.initials: H
authors.lastname: Seki
authors.forename: A
authors.initials: A
authors.lastname: Seno
authors.forename: S
authors.initials: S
authors.lastname: Sakazume
authors.forename: K
authors.initials: K
authors.lastname: Shinoda
authors.forename: N
authors.initials: N
authors.lastname: Shintani
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Koizumi
authors.forename: N
authors.initials: N
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Horita
mesh_terms: D000284:Administration, Oral; D000741:Anemia, Aplastic / Q000188:drug therapy; D001228:Aspergillosis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D015725:Fluconazole / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007275:Injections, Intravenous; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications; D009181:Mycoses / Q000188:drug therapy*; D011208:Powders; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications
chemical_list: D011208:Powders; D015725:Fluconazole