title: No differences in hemodynamics, ventricular function, and oxygen delivery in septic and nonseptic patients with the adult respiratory distress syndrome.
abstract: OBJECTIVE
  To determine whether there are differences in hemodynamics, ventricular function, oxygen delivery, and oxygen consumption between septic and nonseptic patients who have the adult respiratory distress syndrome (ARDS).
  
  
  METHODS
  Cohort analytic study.
  
  
  METHODS
  Tertiary care medical and surgical intensive care unit, university hospital.
  
  
  METHODS
  Eighteen septic (survivors, n = 8; nonsurvivors, n = 10) and 14 nonseptic (survivors, n = 7; nonsurvivors, n = 7) patients studied within 24 hrs of the diagnosis of ARDS.
  
  
  METHODS
  Simultaneous hemodynamic, radionuclide cineangiographic, and oxygen delivery and consumption measurements.
  
  
  RESULTS
  Cardiac index, right and left ventricular ejection fractions, end-diastolic volume indices, oxygen delivery, and oxygen consumption were measured. There were no differences in mean systemic and pulmonary arterial pressures, cardiac index, systemic vascular resistance, right and left ventricular ejection fractions, end-diastolic volumes, and oxygen delivery and consumption between septic and nonseptic patients.
  
  
  CONCLUSIONS
  Early in the course of ARDS, there were no differences in hemodynamics, ventricular function, and oxygen delivery and consumption between septic and nonseptic patients. Sepsis does not account for the previously reported differences in hemodynamics, ventricular function, and oxygen delivery and oxygen consumption between survivors and non-survivors of ARDS. We speculate that both ARDS and sepsis cause release of mediators which cause similar changes in hemodynamics, ventricular function, and oxygen delivery and consumption.
authors.affiliation: Department of Pulmonary Research Laboratory, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ronco
authors.forename: A
authors.initials: A
authors.lastname: Belzberg
authors.forename: P T
authors.initials: PT
authors.lastname: Phang
authors.forename: K R
authors.initials: KR
authors.lastname: Walley
authors.forename: P M
authors.initials: PM
authors.lastname: Dodek
authors.forename: J A
authors.initials: JA
authors.lastname: Russell
mesh_terms: D000328:Adult; D000368:Aged; D002932:Cineangiography; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007239:Infections / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors; D016276:Ventricular Function