[The safety and protective properties of a new cell-free pertussis vaccine in animal trials].
The preclinical trial of a new cell-free pertussis vaccine has been carried out with a view to its comparison with whole-cell pertussis vaccine in respect of the toxic and protective properties of the preparations under experimental conditions. The whole-cell pertussis vaccine is characterized by pronounced toxic action causing leukocytosis and histamine-sensitization, produces a negative effect on the detoxifying function of the liver and possesses sensitizing activity. The cell-free pertussis vaccine has pronounced protective activity. In animal experiments the supposed immunization dose of this vaccine has proved to be nontoxic.
Bazhanova
I G
IG
Remova
T N
TN
Ozeretskovskaia
M N
MN
Shmeleva
E I
EI
Mertsalova
N U
NU
Sukhinova
E E
EE
Chuprinina
R P
RP
Bulk
V F
VF
Semina
I E
IE
Koval'skaia
S Ia
SIa
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004356:Drug Storage; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification / Q000633:toxicity*; D013997:Time Factors; D014917:Whooping Cough / Q000517:prevention & control
D010567:Pertussis Vaccine
Issledovanie bezvrednosti i protektivnykh svoĭstv novoĭ beskletochnoĭ kokliushnoĭ vaktsiny v opytakh na zhivotnykh.