Reduction in CD1 positive epidermal Langerhans cell numbers in leprosy lesions following epicutaneous application of 2:4 dinitrochlorobenzene.
A study was made on Langerhans cells (LC) in the dermal lesions of leprosy after epicutaneous application of 2:4 dinitrochlorobenzene (DNCB) to the lesion. LC were quantitated with OKT6 monoclonal antibody and indirect immunofluorescence. A depletion or reduction in the numbers of CD1+ epidermal LC was observed at both 4 and 24 hours after the application of DNCB in the lesions of both tuberculoid and lepromatous leprosy, compared to untreated lesions.
Narayanan
R B
RB
Central JALMA Institute for Leprosy (ICMR), Agra.
Natarajan
M
M
Bagga
A K
AK
Katoch
K
K
D000279:Administration, Cutaneous; D000911:Antibodies, Monoclonal; D002452:Cell Count / Q000187:drug effects; D004137:Dinitrochlorobenzene / Q000627:therapeutic use*; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects* / Q000473:pathology; D015440:Leprosy, Lepromatous / Q000188:drug therapy*; D015441:Leprosy, Tuberculoid / Q000188:drug therapy*
D000911:Antibodies, Monoclonal; D004137:Dinitrochlorobenzene