title: Laser therapy versus cryotherapy of lentigines: a comparative trial.
abstract: BACKGROUND
  Lentigines are common sun-induced benign melanocytic proliferations. Many therapies have been advocated, but few have been systemically evaluated.
  
  
  OBJECTIVE
  We studied the effectiveness of two laser modalities in comparison with liquid nitrogen cryotherapy for lentigines.
  
  
  METHODS
  We conducted a randomized, controlled, prospective trial comparing liquid nitrogen cryotherapy, argon laser light delivered by a Dermascan shuttered delivery system, and low-fluence carbon dioxide laser irradiation in the treatment of solar lentigines at 99 sites in 13 patients.
  
  
  RESULTS
  Cryotherapy was more likely to produce substantial lightening than either argon or CO2 laser treatment, which gave similar results (p < 0.05 for both comparisons). The odds of an excellent results were about 50% higher with cryosurgery than with CO2 or argon laser therapy.
  
  
  CONCLUSIONS
  Liquid nitrogen cryotherapy was superior to argon and CO2 laser therapy in the treatment of benign epidermal pigmented lesions. This study demonstrates that comparative rather than uncontrolled studies are needed to judge the relative efficacy of therapies for benign pigmented lesions such as lentigines.
authors.affiliation: Department of Dermatology, Beth Israel Hospital, Boston, MA 02215.
authors.forename: R S
authors.initials: RS
authors.lastname: Stern
authors.forename: J S
authors.initials: JS
authors.lastname: Dover
authors.forename: J A
authors.initials: JA
authors.lastname: Levin
authors.forename: K A
authors.initials: KA
authors.lastname: Arndt
mesh_terms: D001128:Argon; D002245:Carbon Dioxide; D003452:Cryosurgery; D005500:Follow-Up Studies; D006801:Humans; D017075:Laser Coagulation; D007911:Lentigo / Q000473:pathology / Q000601:surgery*; D009584:Nitrogen; D011446:Prospective Studies; D012880:Skin Pigmentation; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide; D001128:Argon; D009584:Nitrogen