title: Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.
abstract: The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P < 0.01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts were verified in this preliminary study.
authors.affiliation: Center for Molecular Biology, Heidelberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Czech
authors.forename: H
authors.initials: H
authors.lastname: Förstl
authors.forename: F
authors.initials: F
authors.lastname: Hentschel
authors.forename: U
authors.initials: U
authors.lastname: Mönning
authors.forename: C
authors.initials: C
authors.lastname: Besthorn
authors.forename: C
authors.initials: C
authors.lastname: Geiger-Kabisch
authors.forename: H
authors.initials: H
authors.lastname: Sattel
authors.forename: C
authors.initials: C
authors.lastname: Masters
authors.forename: K
authors.initials: K
authors.lastname: Beyreuther
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000473:pathology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D002784:Cholesterol / Q000097:blood*; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002784:Cholesterol