[Effects of AE0047, a novel Ca antagonist, on monoamine, acetylcholine and neuroactive amino acids contents in rat brain].
Effects of AE0047, a novel calcium antagonist, on monoamine, acetylcholine (ACh) and neuroactive amino acid contents in rat brain were examined. Cerebral ACh content was elevated by the administration of AE0047 (100 mg/kg, p.o.). Striatal norepinephrine and dopamine contents were decreased and increased, respectively, following the administration of 10 mg/kg and 100 mg/kg of AE0047. The administration of AE0047 (10, 30 and 100 mg/kg, p.o.) invariably induced increases in 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid contents in the cerebral cortex. Although AE0047 (100 mg/kg, p.o.) had no effect on the tryptophan hydroxylase activity in the cerebral cortex, striatum and hippocampus, in vitro addition of 10(-8)-10(-6) M AE0047 induced a significant increase of [14C]5-HT uptake into cerebral cortical slices. AE0047 administration (30 and 100 mg/kg, p.o.) also induced a significant decrease of cortical taurine content. These results suggest that AE0047 may be a drug that stimulates 5-HT turnover via the accentuation of 5-HT uptake.
Hashimoto
T
T
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Katsura
M
M
Kuriyama
K
K
D000109:Acetylcholine / Q000032:analysis*; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D015306:Biogenic Monoamines / Q000032:analysis*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004095:Dihydropyridines / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D000596:Amino Acids; D015306:Biogenic Monoamines; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C064970:AE0047; D012701:Serotonin; D014365:Tryptophan Hydroxylase; D000109:Acetylcholine