Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria.
A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine-stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin-binding protein, the histidine-rich protein II, the S-antigen, the heat shock protein 70, the ring-infected erythrocyte surface antigen, and the apical membrane antigen-1 were also shown serologically to be present in the mixture of exoantigens.
Jakobsen
P H
PH
University of Copenhagen, Department of Infectious Diseases, Denmark.
Hundt
E
E
Hansen
M B
MB
Knapp
B
B
D000595:Amino Acid Sequence; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis / Q000276:immunology*; D000953:Antigens, Protozoan / Q000032:analysis / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D006360:Heat-Shock Proteins / Q000032:analysis / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000032:analysis / Q000276:immunology; D015151:Immunoblotting; D007123:Immunoelectrophoresis, Two-Dimensional; D017780:Malaria Vaccines / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology / Q000517:prevention & control*; D008969:Molecular Sequence Data; D011506:Proteins / Q000032:analysis / Q000276:immunology; D015800:Protozoan Proteins / Q000032:analysis / Q000276:immunology; D011817:Rabbits; D000099053:Histidine-Rich Glycoprotein
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D006360:Heat-Shock Proteins; D007106:Immune Sera; D017780:Malaria Vaccines; D011506:Proteins; D015800:Protozoan Proteins; D000099053:Histidine-Rich Glycoprotein; C050256:ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum; C057495:serine repeat antigen, Plasmodium