Non-invasive evaluation of the cardiac function in golden retriever dogs by radionuclide angiography.
Golden Retriever dogs manifest an X-linked, Duchenne-like, muscular dystrophy with a characteristic lack of dystrophin. Histologic findings have demonstrated the cardiac involvement in these dogs to be a model for the cardiac insufficiency in human Duchenne muscular dystrophy (DMD). The goal of this study was to assess the capability of radionuclide angiography (RNA) as an assessment tool to measure the ventricular dysfunction in these dogs. Three dogs, one normal and two with muscular dystrophy (MD), were studied by equilibrium gated blood pool. Red blood cells were labelled with 420 MBq of 99mTc. The three dogs lying on their left sides on the table, received no drugs and were not restrained in any manner. RNA left ejection fraction (EF) and echographic measurements of left ventricular fractional shortening (FS) were performed during the same session. EF values were 61%, 48%, 36% and FS values were 47%, 32%, 26%, respectively, for the control dog, the 6 month old MD dog and the 12 month old MD dog. This preliminary study demonstrates the potential usefulness of RNA for the non-invasive follow-up exams of specific therapy in a canine model of muscular dystrophy.
Devaux
J Y
JY
E.A. 215 Biophysique C.H.U. Cochin, Paris, France.
Cabane
L
L
Esler
M
M
Flaouters
H
H
Duboc
D
D
D000818:Animals; D004285:Dogs; D016189:Dystrophin / Q000172:deficiency / Q000235:genetics; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000662:veterinary; D006321:Heart / Q000000981:diagnostic imaging* / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009137:Muscular Dystrophy, Animal / Q000503:physiopathology*; D013667:Technetium
D016189:Dystrophin; D013667:Technetium