Effects of an acidic, lactate-based peritoneal dialysis solution and its euhydric, bicarbonate-based counterpart on neutrophilic intracellular pH.
An exposure of human neutrophils to an acidic (pH 5.2), lactate-based incubation mixture containing a conventional, acidic, lactate-based peritoneal dialysis solution (PDS) resulted in the development of a prompt and substantial intracellular acidosis. A comparable exposure to a euhydric, bicarbonate-based incubation mixture containing a euhydric, bicarbonate-based PDS did not bring about similar changes in intracellular pH. The absence of an intracellular acidosis in the instance of the euhydric, bicarbonate-based PDS may be the reason why this solution is more biocompatible than its acidic, lactate-based counterpart.
Zhou
X J
XJ
Department of Medicine, University of California at Irvine.
Yu
A W
AW
Zhou
F Q
FQ
Ryu
J
J
Ing
T S
TS
Vaziri
N D
ND
D001639:Bicarbonates; D015314:Dialysis Solutions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007773:Lactates; D009504:Neutrophils / Q000378:metabolism*; D010530:Peritoneal Dialysis
D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates