title: Empirical modelling of chemical exposure in the rubber-manufacturing industry.
abstract: As part of a study of working conditions chemical exposure was assessed in 10 rubber-manufacturing plants in The Netherlands. Personal exposures to airborne particulates, rubber fumes and solvents, and also dermal contamination, were measured. To identify factors affecting exposure the personal exposure levels and information on tasks performed, ventilation characteristics and production variables were used in multiple linear regression models. The exposure was generally very variable. The specific circumstances in each department of each plant determined the actual levels of exposure to a large extent. The factors affecting exposure turned out to be different for each of the types of exposure considered. The model for exposure to airborne particulates explained 40% of the total variability and incorporating the actual time spent on a task only slightly improved the model (R2 = 0.42). The handling of chemicals in powder form was the main factor affecting exposure, forced ventilation having a negligible effect. The model for exposure to curing fumes (measured as the cyclohexane-soluble fraction of the particulate matter) explained 50% of the variability. Both curing temperature and pressure determined the level of rubber fumes. Local exhaust ventilation showed a significant exposure reducing effect. The effect of curing different elastomers was not statistically significant. Dermal exposure to cyclohexane-soluble matter could only be explained to a limited extent (R2 = 0.22). Tasks with frequent contact with (warm) compound and maintenance tasks in the engineering services departments resulted in high dermal exposure. Tasks in which solvents were directly used explained 56% of the variation in solvent exposures. Exposure data, together with information on tasks, methods of work, ventilation and production throughout a branch of industry, can be used to derive empirical statistical models which occupational hygienists can apply to study factors affecting exposure. These determining factors are of crucial importance, whenever hazard control or epidemiological research is the ultimate goal.
authors.affiliation: Department of Air Quality, Wageningen Agricultural University, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Kromhout
authors.forename: P
authors.initials: P
authors.lastname: Swuste
authors.forename: J S
authors.initials: JS
authors.lastname: Boleij
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis; D002617:Chemical Industry; D005260:Female; D006801:Humans; D008297:Male; D008432:Mathematical Computing; D008962:Models, Theoretical; D009426:Netherlands; D016273:Occupational Exposure; D012408:Rubber / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism; D012997:Solvents / Q000032:analysis
chemical_list: D000395:Air Pollutants, Occupational; D012997:Solvents; D012408:Rubber