title: Clonal chromosome aberrations in three sacral chordomas.
abstract: Cytogenetic analysis was successful in seven of eight sacral chordomas. Clonal chromosome aberrations were detected in three. One had a t(1;6)(q44;q11) as the sole aberration, one displayed three near-diploid clones that shared del(2)(p21), del(9)(p13), -10, structural rearrangements of 12q13, and add(19)(p13), and the third chordoma had two aberrant cell populations--one hypodiploid with several numerical and structural changes, the other hypertriploid-hypotetraploid with all marker chromosomes in duplicate. Including the present cases, seven cytogenetically aberrant chordomas have been reported. Five have had hypodiploid clones and the most frequent changes have been -3, -4, -10, and -13. No recurrent structural rearrangement has been identified; the only chromosome bands involved more than once are 1q21, 3q11, 5p15, 20q13, and 21q22.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: A
authors.initials: A
authors.lastname: Kreicbergs
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: B
authors.initials: B
authors.lastname: Carlén
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
mesh_terms: D000328:Adult; D000368:Aged; D002817:Chordoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012447:Sacrum / Q000473:pathology; D014178:Translocation, Genetic