title: [Immunostimulation in heart surgery: thymostimulin. Preliminary data].
abstract: The immunodepressive effect of surgical procedures is well known. Immunotherapy with thymic hormones has used a long time to prevent surgical immunitary damage. In cardiac surgery, we can observe a hard immunitary depression caused by the cardiopulmonary bypass (CBP). In this paper we evaluate the response to immunotherapy, with an extractive thymic hormone: thymostimulin at the dosage of 1 mg/kg/day; 20 patients of a group of 40 underwent CBP. Immunological monitoring was obtained with the "multitest CMI", a disposable skin test to evaluate changes of lymphocytes, especially T cells. Results shows a significant increase of response in patients treated with thymostimulin versus control. A larger sample and a deeper immunitary assessment will be provided in the future.
authors.affiliation: Istituto di Chirurgia Toracica e Cardiovascolare, Ospedale Le Scotte, Università degli Studi di Siena.
authors.forename: M
authors.initials: M
authors.lastname: Maccherini
authors.forename: G
authors.initials: G
authors.lastname: Davoli
authors.forename: G
authors.initials: G
authors.lastname: Sani
authors.forename: F
authors.initials: F
authors.lastname: Miraldi
authors.forename: G
authors.initials: G
authors.lastname: Gotti
authors.forename: M
authors.initials: M
authors.lastname: Toscano
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host / Q000276:immunology*; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011183:Postoperative Complications / Q000276:immunology* / Q000517:prevention & control*; D013949:Thymus Extracts / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D013949:Thymus Extracts; C031407:thymostimulin
vernacular_title: Immunostimolanti in cardiochirurgia: timostimolina. Dati preliminari.