title: Knowledge-based approach to clinical decision-support system, with an application in tetanus serology.
abstract: In tetanus immunization, the need for a booster vaccination can be easily determined by a serological analysis of tetanus antitoxin. Vaccination without knowledge of the immune status carries a high risk of postvaccinal complications. We have used the Pro. M.D. expert system shell to produce the knowledge base TETANUS, to improve the diagnostic interpretation of tetanus antitoxin findings. This knowledge base is comprehensive, runnable, useful, and modifiable by anyone who works with Pro.M.D. and is able to provide medical knowledge in this field.
authors.affiliation: Department of Medical Informatics, Federal Armed Forces Medical Office, Bonn, Germany.
authors.forename: J P
authors.initials: JP
authors.lastname: Schröder
authors.forename: W D
authors.initials: WD
authors.lastname: Kuhlmann
authors.forename: C H
authors.initials: CH
authors.lastname: Trendelenburg
mesh_terms: D000992:Antitoxins / Q000097:blood*; D003660:Decision Support Systems, Management; D005103:Expert Systems; D006801:Humans; D007117:Immunization, Secondary; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D000992:Antitoxins; D013745:Tetanus Toxoid