title: [Morphological and immunohistochemical observations on 30 cases of neuroendocrine carcinoma of the lung].
abstract: 30 cases of resected pulmonary neuroendocrine carcinoma (NEC) collected from September 1983 to February 1992 were confirmed by microscopy, electron microscopy and immunohistochemical observations. Of the 30 cases, 8 were typical carcinoid (TC), 15 atypical carcinoid (AC), 5 small cell lung carcinoma (SCLC) and 2 cases of giant cell neuroendocrine carcinoma (LCNEC), which have never been reported in the literature. This series of pulmonary NEC exhibited their specific morphology under light microscope. Electron microscopic examination found the common feature of neuroendocrine granules in the cytoplasm of carcinoma cells. Immunohistochemical studies with neuroendocrine cell markers for NEC gave positive results. The morphological features and differential diagnosis of the various NEC under light microscope and electron microscope were compared and are discussed. Complimental devise to the classification of NECs of the lung is suggested.
authors.affiliation: Department of Pathology, General Hospital of the PLA, Beijing.
authors.forename: W H
authors.initials: WH
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000145:classification / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis
chemical_list: D010751:Phosphopyruvate Hydratase