[Parenteral nutrition-associated cholestasis: the effect of diets free of taurine and its metabolic precursors on bile composition and liver structure].
OBJECTIVE
To study the morphological and biliary alterations associated with taurine-free parenteral nutrition and its other precursors.
One fed a standard taurine-free amino acid formula, a group fed without taurine or its metabolic precursors, and a control group. At the beginning and end of the experiment, analyses were made of nutritional parameters, hepatic enzymes, biliary composition, plasmatic aminogram and optical and electronic microscopy of the liver.


RESULTS
Significant increases of threonine, glutamine, alanine, lysine, histidine and arginine, and insignificant increases of taurine, serine, isoleucine and leucine in groups with PN. Increased Non-conjugated AB, particularly lithocholic and taurolithocholic acid in groups without taurine precursors. Fat microsteatosis in area 3 of the acinus in the group without taurine, and in the three areas in the group without precursors. Standard taurine-free PN causes changes in the biliary composition and liver histology, which increase in the absence of taurine precursors.
Salas Martínez
J
J
Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Facultad de Medicina, Universidad de Extremadura, España.
Morán Penco
J M
JM
Maciá Botejara
E
E
Vinagre Velasco
L M
LM
D000596:Amino Acids / Q000097:blood / Q000187:drug effects; D000818:Animals; D001646:Bile / Q000737:chemistry / Q000187:drug effects*; D002779:Cholestasis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004032:Diet / Q000009:adverse effects*; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008715:Methionine / Q000494:pharmacology*; D008854:Microscopy, Electron; D010288:Parenteral Nutrition / Q000009:adverse effects*; D011817:Rabbits; D013654:Taurine
D000596:Amino Acids; D013654:Taurine; D008715:Methionine
Colestasis asociada a nutrición parenteral: influencia de las dietas exentas de taurina y de sus precursores metabólicos sobre la composición biliar y la estructura hepática.