Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1.
To identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers only those with a diagnosis of schizophrenia or schizoaffective disorder as affected, a random search of the genome for detection of linkage was undertaken. Pairwise linkage analyses suggest a potential linkage (LRH = 34.7 or maximum lod score = 1.54) for one region (22q12-q13.1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies.
Pulver
A E
AE
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore 21231.
Karayiorgou
M
M
Wolyniec
P S
PS
Lasseter
V K
VK
Kasch
L
L
Nestadt
G
G
Antonarakis
S
S
Housman
D
D
Kazazian
H H
HH
Meyers
D
D
D000328:Adult; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010552:Personality Assessment; D012044:Regression Analysis; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers