Novel nematocidal agents from Curcuma comosa.
Curcuma comosa is a member of the economically important plant family, Zingiberaceae. A methanolic extract of C. comosa was shown to be nematocidal when tested against the free-living nematode Caenorhabditis elegans. Five diphenylheptanoids [1-5], one new and four known, have been isolated and shown to be responsible for the activity. This is the first report of three of these compounds [1, 2, 4] being isolated from a natural source.
Jurgens
T M
TM
Merck Research Laboratories, Rahway, New Jersey 07065.
Frazier
E G
EG
Schaeffer
J M
JM
Jones
T E
TE
Zink
D L
DL
Borris
R P
RP
Nanakorn
W
W
Beck
H T
HT
Balick
M J
MJ
D000818:Animals; D000969:Antinematodal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D017173:Caenorhabditis elegans / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000032:analysis / Q000633:toxicity; D010944:Plants / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000969:Antinematodal Agents; D010936:Plant Extracts; D003474:Curcumin