[Suppression of influenza virus NP-protein mRNA translation in vitro with derivatives of an antisense oligonucleotide].
Inhibition of the influenza virus protein NP mRNA with derivatives of an antisense oligonucleotide complementary to the 5' terminus of the mRNA was investigated. The derivatives were prepared by conjugation of aromatic 2-chloroethylamine, cholesterol, porphyrin, and phenazine groups to the 5'-terminal phosphate of the oligonucleotide. The most efficient inhibitors were found to be the conjugates bearing the alkylating, cholesterol and phenaznium groups.
Abramova
T V
TV
Vlasov
V V
VV
Ivanova
E M
EM
Zarytova
V F
VF
Fokina
T N
TN
Frolova
E I
EI
Iurchenko
L V
LV
D001483:Base Sequence; D002784:Cholesterol / Q000378:metabolism; D005021:Ethylamines / Q000378:metabolism; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D009975:Orthomyxoviridae / Q000378:metabolism*; D010619:Phenazines / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*; D012333:RNA, Messenger / Q000235:genetics*; D014758:Viral Core Proteins / Q000235:genetics*
D005021:Ethylamines; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D016376:Oligonucleotides, Antisense; D010619:Phenazines; D011166:Porphyrins; D012333:RNA, Messenger; D014758:Viral Core Proteins; D002784:Cholesterol; C010076:2-chloroethylamine
Podavlenie transliatsii mRNK NP-belka virusa grippa in vitro proizvodnymi antismyslovogo oligonukleotida.