title: Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy.
abstract: BACKGROUND
  The authors determined the patterns of treatment failure in patients treated with surgery alone or surgery combined with postoperative radiation therapy for squamous cell carcinoma of the tonsil.
  
  
  METHODS
  Seventy-two patients underwent surgery alone (56) or surgery and postoperative adjuvant radiation therapy (16). All patients were followed up until death (40 patients) or for a minimum of 3.5 years. For patients treated with surgery alone, clinic notes, operative notes, and pathology reports and slides were reviewed to identify clinical or pathologic predictors of recurrence above the clavicles, cause-specific survival, and overall survival. For patients undergoing postoperative adjuvant radiation therapy, demographic, treatment, and pathologic variables were analyzed to identify factors associated with control of disease above the clavicles, disease-free survival, and overall survival.
  
  
  RESULTS
  The main pattern of treatment failure was above the clavicles. It occurred in 39% of patients treated with surgery alone and was significantly related (P = 0.002) to the overall clinical TNM stage. Disease recurrence above the clavicles occurred in 31% of patients undergoing surgery and postoperative adjuvant radiation therapy, despite their more advanced neck disease. Five-year overall survival for patients with clinical Stage III and IV disease who were treated with surgery and post-operative adjuvant radiation therapy was 100% and 78%, respectively. Five-year overall survival for patients treated with surgery alone who had clinical Stage III, IVA, or IVB disease was 56%, 43%, and 50%, respectively.
  
  
  CONCLUSIONS
  We recommend postoperative adjuvant radiation therapy for patients with clinical Stage III or IV squamous cell carcinoma of the tonsil who have undergone complete surgical resection because this appears to improve control of disease above the clavicles and overall survival.
authors.affiliation: Division of Radiation Oncology, Mayo Clinic, Rochester, MN 55905.
authors.forename: R L
authors.initials: RL
authors.lastname: Foote
authors.forename: S E
authors.initials: SE
authors.lastname: Schild
authors.forename: W M
authors.initials: WM
authors.lastname: Thompson
authors.forename: S J
authors.initials: SJ
authors.lastname: Buskirk
authors.forename: K D
authors.initials: KD
authors.lastname: Olsen
authors.forename: R J
authors.initials: RJ
authors.lastname: Stanley
authors.forename: S J
authors.initials: SJ
authors.lastname: Kunselman
authors.forename: D J
authors.initials: DJ
authors.lastname: Schaid
authors.forename: J P
authors.initials: JP
authors.lastname: Grill
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011182:Postoperative Care; D014067:Tonsillar Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D017211:Treatment Failure