title: Improving the induction characteristics of methohexitone. A study of the effect of adding thiopentone to methohexitone.
abstract: A double-blind, randomised, controlled study was undertaken to investigate the effects on injection pain and excitatory phenomena of adding thiopentone to methohexitone. One hundred and twenty unpremedicated, day-case patients received one of four induction regimens: unmodified 1% methohexitone, or a mixture of 2.5% thiopentone and 1% methohexitone in ratios of 1:1, 1:3 or 1:9 by volume. The addition of one part of thiopentone to three parts of methohexitone produced a mixture which significantly reduced the occurrence of pain and discomfort compared with methohexitone alone from 67% to 13% (p < 0.01) and reduced the occurrence of excitatory effects from 50% to 13% (p < 0.01).
authors.affiliation: Department of Anaesthetics, Pilgrim Hospital, Boston, Lincolnshire.
authors.forename: J H
authors.initials: JH
authors.lastname: Raphael
authors.forename: M D
authors.initials: MD
authors.lastname: Bexton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D005260:Female; D006606:Hiccup / Q000517:prevention & control; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D007826:Laryngismus / Q000517:prevention & control; D008297:Male; D008723:Methohexital; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D010146:Pain / Q000517:prevention & control; D013874:Thiopental
chemical_list: D008723:Methohexital; D013874:Thiopental