Co-expression of c-abl and c-myb oncogenes in Philadelphia chromosome-negative, bcr-negative chronic myeloid leukaemia.
Three cases of Philadelphia (Ph) chromosome-negative, bcr-negative chronic myeloid leukaemia (CML) have been investigated for oncogene expression by Northern blot and cytoplasmic RNA dot blot hybridization. Considerably high levels of expression of c-abl and c-myb were observed in all cases. In the Ph-negative cells the normal 6.0 and 7.0 kb c-abl and 3.8 kb c-myb transcripts were found. No amplification of c-abl or c-myb oncogenes was detected in the DNAs of Ph-negative CML cells. Data suggest that co-operation between the overexpressed c-abl and c-myb oncogenes is causally related to Ph-negative bcr-negative CML.
Tóth
F D
FD
Institute of Microbiology, University Medical School, Debrecen, Hungary.
Kiss
J
J
Kiss
A
A
Telek
B
B
Oláh
E
E
Iványi
J
J
Rak
K
K
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D015321:Gene Rearrangement; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D008297:Male; D009857:Oncogenes / Q000235:genetics*; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016315:Proto-Oncogene Proteins c-abl / Q000032:analysis*; D020598:Proto-Oncogene Proteins c-myb
D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D016315:Proto-Oncogene Proteins c-abl