title: Higher levels of microproteinuria in Asian compared with European patients with diabetes mellitus and their relationship to dietary protein intake and diabetic complications.
abstract: Asian patients with diabetes have a higher prevalence of renal disease than their European counterparts. The aim of the study was to investigate the pattern of the renal excretion of proteins in 70 Asian and 70 European patients with diabetes and to relate it to dietary intake of protein and prevalence of diabetic complications. Compared with matched Europeans, Asian patients had an increased urinary excretion of albumin and transferrin (p < 0.02) with 14 Asians and 6 Europeans having significant microalbuminuria (> 30 micrograms min-1). In 12 Asians and all 6 Europeans this was associated with complications from diabetes, particularly vascular. Asian patients had significantly more ischaemic heart disease (p < 0.001) but less neuropathy (p < 0.001) and retinopathy (p < 0.05) than their matched European counterparts. Asian diets were lower in protein (median (range) Asian vs European: 12.5% (6-29%) vs 19% (11-27%); p < 0.01) and carbohydrate but higher in fat than European diets. There was no correlation between dietary protein intake and excretion of any of the urinary proteins measured. However, a significant correlation was found in Asians between protein intake and length of residence in the UK (p < 0.005). Unless ways to reduce complications can be found then future allocation of resources will need to take this into consideration in areas with large Asian communities.
authors.affiliation: Academic Unit of Medicine, General Infirmary, Leeds, UK.
authors.forename: H
authors.initials: H
authors.lastname: Tindall
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: D
authors.initials: D
authors.lastname: Nagi
authors.forename: S
authors.initials: S
authors.lastname: Pinnock
authors.forename: M
authors.initials: M
authors.lastname: Stickland
authors.forename: J A
authors.initials: JA
authors.lastname: Davies
mesh_terms: D000328:Adult; D000368:Aged; D001208:Asia / Q000208:ethnology; D003920:Diabetes Mellitus / Q000652:urine*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000453:epidemiology*; D003930:Diabetic Retinopathy / Q000453:epidemiology*; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D004739:England / Q000453:epidemiology; D005060:Europe / Q000208:ethnology; D006801:Humans; D008875:Middle Aged; D011507:Proteinuria
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins