[The autoregulation of the coronary flow of the isolated heart in rats after saponin damage to the endothelium].
The damage of the endothelium with saponin completely abolished the autoregulation of the coronary vessels in the Langendorff isolated heart and reduced the volume velocity of the coronary blood flow by 34% at the perfusion pressure 40 mmHg. Indomethacin and verapamil augmented the coronary flow in intact rats. All these agents decreased the distensibility of the coronary vessels by 43-49% on the average. The damage of the endothelium of coronary vessels reduced the maximum reactive hyperemia and, respectively, the coronary vasodilator reserve.
Solodkov
A P
AP
Shebeko
V I
VI
Bozhko
A P
AP
Rodionov
Iu Ia
IuIa
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D010477:Perfusion / Q000379:methods; D051381:Rats; D012503:Saponins / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology
D012503:Saponins; D014700:Verapamil; D007213:Indomethacin
Autoreguliatsiia koronarnogo potoka izolirovannogo serdtsa krys posle povrezhdeniia éndoteliia saponinom.