Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.
A strictly anaerobic bacterium capable of metabolizing sennosides was isolated from human feces and identified as Bifidobacterium sp., named strain SEN. The bacterium hydrolyzed sennosides A and B to sennidins A and B via sennidin A and B 8-monoglucosides, respectively. Among nine species of Bifidobacterium having beta-glucosidase activity, only Bifidobacterium dentium and B. adolescentis metabolized sennoside B to sennidin B, suggesting that the sennoside-metabolizing bacteria produce a novel type of beta-glucosidase capable of hydrolyzing sennosides to sennidins.
Akao
T
T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Che
Q M
QM
Kobashi
K
K
Yang
L
L
Hattori
M
M
Namba
T
T
D000873:Anthracenes / Q000378:metabolism*; D000880:Anthraquinones / Q000378:metabolism*; D001644:Bifidobacterium / Q000302:isolation & purification / Q000378:metabolism*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D006868:Hydrolysis; D012676:Senna Extract; D000081226:Sennosides; D013045:Species Specificity
D000873:Anthracenes; D000880:Anthraquinones; D000081226:Sennosides; C013946:dihydroxydianthrone; D012676:Senna Extract