Near-visible-UV radiation delays UVB tumorigenesis.
The effect of UVA radiation (321-400 nm) on UVB photocarcinogenesis was examined in lightly pigmented hairless hr/hr C3H/Tif mice. Five groups of 22 mice were exposed to UVB radiation (281-320 nm) from one Philips 12 tube for 10 min per day and 4 days per week. Four of the groups were simultaneously exposed to UVA from two to six filtered Philips 09 tubes. The daily dose of UVB was 2.0 kJ m-2 in all five groups; the UVA2 (321-340 nm) dose varied from 0.7 to 4.5 kJ m-2 and the UVA1 (341-400 nm) dose from 0.3 to 45.6 kJ m-2. A sixth group was exclusively irradiated with the filtered UVA tubes and served as a control. Skin tumor development was not significantly different for the groups exposed to the UVB source alone or the UVB source in combination with the largest daily UVA dose (0.2 > p > 0.1). Skin tumor development was significantly delayed in the other groups irradiated with the UVB source and the lower doses of UVA (p < 0.001). No tumors were observed in the control group. This study suggests that UVA1 radiation delays UVB-induced skin tumor development. However, the delay cannot be expected to persist when UVA is administered in higher daily doses.
Bech-Thomsen
N
N
Department of Dermatology, Copenhagen University Hospital, Denmark.
Poulsen
T
T
Christensen
F G
FG
Lundgren
K
K
Wulf
H C
HC
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D008809:Mice, Inbred C3H; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D013997:Time Factors; D014466:Ultraviolet Rays