title: [Allergic vasculitis caused by Vigabatrin].
abstract: A patient with focal epilepsy that was resistant to medical treatment received add-on therapy with vigabatrin. Six months after commencement of vigabatrin therapy, allergic vasculitis caused by vigabatrin was diagnosed. The patient displayed unilateral anterior ischaemic optic neuropathy with impairment of vision and concentric loss of visual field. The diagnosis was based on the lymphocyte transformation test and the clinical course. The allergic vasculitis was healed by cortisone therapy.
authors.affiliation: Erwachsenenklinik am Epilepsiezentrum Kork, Medizinischen Universitätsklinik Tübingen.
authors.forename: L
authors.initials: L
authors.lastname: Dieterle
authors.forename: E W
authors.initials: EW
authors.lastname: Becker
authors.forename: P A
authors.initials: PA
authors.lastname: Berg
authors.forename: R
authors.initials: R
authors.lastname: Berkenfeld
authors.forename: G
authors.initials: G
authors.lastname: Reinshagen
mesh_terms: D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004342:Drug Hypersensitivity / Q000209:etiology*; D004828:Epilepsies, Partial / Q000188:drug therapy*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005074:Evoked Potentials, Visual / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D008134:Long-Term Care; D008297:Male; D009900:Optic Nerve / Q000098:blood supply*; D009902:Optic Neuritis / Q000139:chemically induced*; D011930:Reaction Time / Q000187:drug effects; D020888:Vigabatrin
chemical_list: D000614:Aminocaproates; D000927:Anticonvulsants; D020888:Vigabatrin
vernacular_title: Allergische Vaskulitis durch Vigabatrin.