Synthesis and antibacterial activity of new 2-substituted penems. II.
A series of new penems (4-17), having a bicyclic imidazole moiety as the C-2 substituent, has been synthesized. The antimicrobial activity of these compounds and their susceptibility to renal dehydropeptidase-1 (DHP-1) are elucidated, and their structure-activity relationships are discussed.
Nishi
T
T
Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Higashi
K
K
Soga
T
T
Takemura
M
M
Sato
M
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004355:Drug Stability; D007769:Lactams; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007769:Lactams