title: Immunohistochemical localization of plasminogen activator inhibitor type 1 in human brain tumors.
abstract: We investigated the immunohistochemical localization of plasminogen activator inhibitor type 1 (PAI-1) in surgical specimens of 41 human intracranial tumors. Malignant tumors (7 glioblastoma multiforme, 5 anaplastic gliomas, 4 malignant meningiomas, and 9 metastatic tumors) showed consistently stronger PAI-1 immunohistoreactivity than benign or low-grade tumors (5 low-grade gliomas, 8 benign meningiomas, and 3 Schwannomas). Strong PAI-1 positivity was confined to glomeruloid-shaped proliferative vessels seen in high-grade gliomas and metastatic tumors. Blood vessels near necrotic foci and some zones of necrosis also showed strong PAI-1 positivity. PAI-1 localizes in the vascular basement membrane and perivascular connective tissue, while endothelial cells themselves show weak positivity. None of the specimens showed PAI-1 reactivity within the tumor cells per se. Localization of PAI-1 in proliferating vessels suggests that PAI-1 may be involved in angiogenesis.
authors.affiliation: Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: S
authors.initials: S
authors.lastname: Kono
authors.forename: J S
authors.initials: JS
authors.lastname: Rao
authors.forename: J M
authors.initials: JM
authors.lastname: Bruner
authors.forename: R
authors.initials: R
authors.lastname: Sawaya
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D005910:Glioma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008579:Meningioma / Q000378:metabolism / Q000473:pathology; D009362:Neoplasm Metastasis; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*
chemical_list: D017395:Plasminogen Activator Inhibitor 1