title: Iron and erythropoietin measurement in autologous blood donors with anemia: implications for management.
abstract: BACKGROUND
  The importance of autologous blood donation for elective surgery is recognized, and the method is being used at many hospitals. Not all patients are able to deposit a sufficient amount of blood before surgery because they cannot recover rapidly enough from phlebotomy-induced anemia. The ability to donate sufficient blood for autologous use was studied in patients who are particularly susceptible to phlebotomy-induced anemia.
  
  
  METHODS
  Of 840 patients who donated blood for autologous use in elective surgery from November 1987 through May 1993, 20 with rheumatoid arthritis, 24 with iron deficiency anemia, and 37 aged 65 years and above with normocytic anemia were compared with 24 nonanemic elderly patients who donated a total of 1000 mL of blood for autologous use. Patients received iron sulfate orally and donated blood once a week until operation.
  
  
  RESULTS
  The amount of blood collected before surgery per control patient was more than that in others. Consequently, there was a tendency to allogeneic blood transfusion in patients with rheumatoid arthritis or elderly patients. The ferritin levels in controls and in patients with iron deficiency anemia during the donation period were almost within the normal range in spite of iron supplementation, which implied a good utilization of iron sulfate for erythropoiesis. On the other hand, the rise in ferritin levels in the elderly and in patients with rheumatoid arthritis suggested inappropriate iron availability for erythropoiesis and resulted in an increase in iron storage. Since an adequate endogenous erythropoietin response to phlebotomy-induced anemia was not observed in these patients, impaired erythropoietin production was considered one of the reasons for anemia.
  
  
  CONCLUSIONS
  Patients with iron deficiency anemia are able to continue donating blood for autologous use so long as they have sufficient iron supplementation. However, the elderly or those with rheumatoid arthritis occasionally fail to donate a sufficient volume of blood before surgery as a result of phlebotomy-induced anemia, which is caused in turn by impaired erythropoietin production.
authors.affiliation: Blood Transfusion Service, Fukushima Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tasaki
authors.forename: H
authors.initials: H
authors.lastname: Ohto
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: R
authors.initials: R
authors.lastname: Motoki
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Hoshino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000747:Anemia, Hypochromic / Q000097:blood / Q000209:etiology / Q000628:therapy*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000628:therapy; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D001815:Bloodletting / Q000009:adverse effects; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D004921:Erythropoietin; D007501:Iron