Actin-dependent motile forces and cell motility.
Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly in axonal elongation. The major new findings of the past year concerning possible motility roles for myosin describe myosin-driven protrusion of cell margins.
Cramer
L P
LP
Department of Pharmacology, University of California, San Francisco 94143-0450.
Mitchison
T J
TJ
Theriot
J A
JA
D000199:Actins / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D009218:Myosins / Q000378:metabolism / Q000502:physiology*
D000199:Actins; D046911:Macromolecular Substances; D009218:Myosins