title: Cell signalling and motile activity.
abstract: The actin cytoskeleton is a remarkably dynamic structure in non-muscle cells which responds to cell stimulation by a variety of cytokines. A paradigm for such cytokine-induced reorganization of the actin superstructure is the actin response to growth factor of the EGF/PDGF family. This paper reviews the role of the polyphosphoinositide-metabolism, small GTP-binding proteins and profilin in the reorganization of the actin cytoskeleton in cells activated by growth factors.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
authors.forename: A W
authors.initials: AW
authors.lastname: Heldman
authors.forename: P J
authors.initials: PJ
authors.lastname: Goldschmidt-Clermont
mesh_terms: D000199:Actins / Q000502:physiology; D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D003285:Contractile Proteins; D016207:Cytokines / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D008840:Microfilament Proteins / Q000502:physiology; D051304:Profilins
chemical_list: D000199:Actins; D003285:Contractile Proteins; D016207:Cytokines; D008840:Microfilament Proteins; D051304:Profilins; D019204:GTP-Binding Proteins