title: Basis for the selective reduction of pulmonary vascular resistance in humans during infusion of adenosine.
abstract: The objective of this study was to demonstrate the basis for the selective reduction of pulmonary vascular resistance by intravenous infusion of adenosine. Secondary objectives of the study were to determine the rate of central infusion of adenosine at which the nucleoside appears in the systemic circulation and to relate this to hemodynamic events. Plasma concentrations of adenosine in the right and left atria were measured during peripheral (5 patients) and central (12 patients) infusions of adenosine in adults with normal pulmonary arterial pressures undergoing coronary artery bypass surgery. The hemodynamic effects of central (right ventricle) infusion of adenosine were also examined. The extraction of adenosine across the pulmonary vascular bed was found to be 73.6 +/- 4.8%. The mean maximal decrease in pulmonary vascular resistance index, 48.8 +/- 9.6%, occurred at an adenosine infusion rate of 30 micrograms.kg-1.min-1, whereas the systemic vascular resistance index remained unchanged. Thus, adenosine, administered centrally in anesthetized patients with normal pulmonary vascular resistances, selectively lower pulmonary vascular resistance. The basis for this selective effect is the substantial extraction of adenosine during passage through the pulmonary vascular bed.
authors.affiliation: Department of Medicine, University of Florida College of Medicine, Gainesville 32610.
authors.forename: D B
authors.initials: DB
authors.lastname: Utterback
authors.forename: E D
authors.initials: ED
authors.lastname: Staples
authors.forename: S E
authors.initials: SE
authors.lastname: White
authors.forename: J A
authors.initials: JA
authors.lastname: Hill
authors.forename: L
authors.initials: L
authors.lastname: Belardinelli
mesh_terms: D000241:Adenosine / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D003326:Coronary Circulation; D004305:Dose-Response Relationship, Drug; D005260:Female; D006325:Heart Atria; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010991:Plethysmography; D011652:Pulmonary Circulation / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D000241:Adenosine