title: Familial ovarian carcinoma: pedigree studies and preliminary results from linkage analysis.
abstract: Thirty-seven ovarian cancer-prone families have been identified through a French co-operative network. Three main clinical presentations were observed: site-specific ovarian cancer, breast/ovarian carcinoma syndrome and Lynch syndrome II. An additional kindred with features of Li-Fraumeni syndrome is reported. It is expected that a better understanding of the mechanisms of carcinogenesis will allow the development of new methods of screening and treatment. With this aim, recent studies have mapped the gene for early-onset familial breast cancer and breast/ovarian carcinoma syndrome to the same locus in the chromosome 17q12-q23 region. Results from linkage analysis of two breast/ovarian carcinoma families and three breast cancer families favour the hypothesis of genetic heterogeneity among breast and ovarian tumors.
authors.affiliation: Département de médecine, centre Léon-Bérard, Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Sobol
authors.forename: S
authors.initials: S
authors.lastname: Mazoyer
authors.forename: S A
authors.initials: SA
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Lyonnet
authors.forename: Y J
authors.initials: YJ
authors.lastname: Bignon
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
authors.forename: A
authors.initials: A
authors.lastname: Ardoin
authors.forename: P
authors.initials: P
authors.lastname: Biron
authors.forename: J Y
authors.initials: JY
authors.lastname: Bobin
authors.forename: A
authors.initials: A
authors.lastname: Bremond
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics*; D010375:Pedigree