Persistence of alphaviruses in vertebrate hosts.
Alphaviruses are a group of arthropod-borne, positive-strand RNA viruses that cause acute encephalitis or arthritis. These viruses were previously thought to cause only acute infections in vertebrates, but recent evidence suggests that host immunological and tissue-specific factors may act together to promote the persistence of alphavirus genomes in vivo.
Levine
B
B
Dept of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Hardwick
J M
JM
Griffin
D E
DE
D000524:Alphavirus / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D018354:Alphavirus Infections / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice; D014779:Virus Replication