Effect of combination interleukin-1 and erythropoietin in ameliorating the hematopoietic toxicity associated with the use of zidovudine administered to normal mice.
Use of the anti-viral drug zidovudine in the treatment of acquired immunodeficiency syndrome (AIDS) has been associated with the development of hematopoietic toxicity. Several hematopoietic growth factors have been investigated in their ability to modulate such toxicity; however, no single factor has been demonstrated to produce restoration of hematopoiesis following use with zidovudine. We report results describing the effect of combination interleukin-1 (IL-1) and erythropoietin (Epo) in their ability to modulate the hematopoietic toxicity associated with dose-escalation zidovudine administered in normal mice. When administered over a six-week period, IL-1 and Epo raised the packed red cell volume, white blood cell and platelet counts in control mice and mice receiving dose-escalation zidovudine. These effects were attributed in part to the ability of combination IL-1 and Epo to increase erythroid, myeloid and megakaryocyte progenitor stem cells from bone marrow and spleen. These results indicate that use of combined IL-1 and Epo may be efficacious in ameliorating the hematopoietic toxicity associated with the use of zidovudine.
Gallicchio
V S
VS
Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington 40536-0084.
Hughes
N K
NK
Tse
K F
KF
Gaines
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000704:Analysis of Variance; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010976:Platelet Count / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013997:Time Factors; D015215:Zidovudine / Q000633:toxicity*
D007375:Interleukin-1; D004921:Erythropoietin; D015215:Zidovudine