title: Complement factor H and related proteins: an expanding family of complement-regulatory proteins?
abstract: Recently, several factor-H-related molecules have been identified in humans and mice, initiating new interest in this group of serum proteins. Although no complement-regulatory activity has been demonstrated yet for the human factor-H-related proteins, the immunological and structural similarities to factor H suggest overlapping functions. Here, Peter Zipfel and Christine Skerka review these similarities and suggest a new nomenclature to identify members of the factor-H-related family.
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: P F
authors.initials: PF
authors.lastname: Zipfel
authors.forename: C
authors.initials: C
authors.lastname: Skerka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry* / Q000502:physiology*; D017242:Complement Factor H / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D001798:Blood Proteins; C493495:CFH protein, human; D017242:Complement Factor H