The role of small GTP-binding proteins in leukocyte function.
Recent progress in understanding the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) provides the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year indicate that the activity of NADPH oxidase can be modulated by regulation of the GTP- versus GDP-bound state of Rac. Additional proteins of the Ras superfamily are likely to be involved in a variety of normal leukocyte functions.
Bokoch
G M
GM
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.
Knaus
U G
UG
D000818:Animals; D001692:Biological Transport; D019204:GTP-Binding Proteins / Q000502:physiology*; D020730:Guanine Nucleotide Dissociation Inhibitors; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D019255:NADPH Oxidases; D010586:Phagocytes / Q000201:enzymology / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D011499:Protein Processing, Post-Translational; D020744:rac GTP-Binding Proteins; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
D020730:Guanine Nucleotide Dissociation Inhibitors; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins