Infection of human endothelial cells by Rickettsia rickettsii causes a significant reduction in the levels of key enzymes involved in protection against oxidative injury.
The activities of glucose-6-phosphate dehydrogenase, catalase, and glutathione peroxidase were significantly decreased in human endothelial cells infected with the obligate intracellular bacterium Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever. This observation lends additional support to our hypothesis implicating oxidative damage in endothelial cell injury caused by this microorganism.
Devamanoharan
P S
PS
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201.
Santucci
L A
LA
Hong
J E
JE
Tian
X
X
Silverman
D J
DJ
D002374:Catalase / Q000378:metabolism*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000201:enzymology / Q000382:microbiology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D016877:Oxidants / Q000633:toxicity; D012284:Rickettsia rickettsii / Q000472:pathogenicity*
D016877:Oxidants; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase