High-sucrose diet inhibits basal secretion of intradentinal dye penetration-stimulating parotid hormone in pigs.
Earlier studies indicated that feeding rats a high-sucrose diet for 1 wk decreases the intrinsic rate of intradentinal dye penetration in molar teeth. Because intradentinal dye penetration appears to be controlled by a parotid hormone, we investigated the chronic effect of a high-sucrose diet on basal parotid hormone secretion in pigs. In fasted pigs, the plasma immunoreactive parotid hormone titer decreased significantly after substitution of a high-sucrose diet for standard chow and remained at a level 72% lower for 40 days until the diet was reverted to standard chow. Within 3 days of diet reversion, the basal hormone titer returned to its original value. The results indicate that a high-sucrose diet can significantly alter the basal secretion of parotid hormone. The possibility exists that inhibition of intradentinal dye penetration after ingestion of a high-sucrose diet could be the result of depressed parotid hormone secretion.
Tieche
J M
JM
Department of Physiology, School of Medicine, Loma Linda University, California 92350.
Leonora
J
J
Steinman
R R
RR
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D003804:Dentin / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D006728:Hormones / Q000378:metabolism*; D008297:Male; D010306:Parotid Gland / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000008:administration & dosage*; D013552:Swine
D001786:Blood Glucose; D006728:Hormones; D013395:Sucrose