title: [Tissue immunity reactions in experimental aspergillosis].
abstract: The authors have developed a model of acute and chronic aspergillosis induced by Aspergillus fungi injected intraperitoneally to white mice. Subsequent histological evaluation of the mouse viscera identified 3 phases of tissue immunity reactions: non-specific, characterized by mucosal epithelial proliferation and hypersecretion, lymphoid reaction and development of diffuse alveolitis in the lungs, rapid growth of aspergilla; specific, characterized by pronounced proliferative processes, onset of lymphoid-histiocytic and macrophagal pneumonia, emergence of small thin-wall intraalveolar micetomas, absence of aspergilla growth from homogenates of the internal organs; productive, characterized by formation of granuloma, large aspergillomas in the liver and mesenterium. The course of experimental aspergillosis reflects the process of immunity formation in response to advancing infection.
authors.forename: V V
authors.initials: VV
authors.lastname: Epokhin
authors.forename: E S
authors.initials: ES
authors.lastname: Zemskova
authors.forename: I R
authors.initials: IR
authors.lastname: Dorozhkova
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000276:immunology*; D004195:Disease Models, Animal; D051379:Mice
vernacular_title: Tkanevye reaktsii immuniteta pri éksperimentalńom aspergilleze.