title: Diabetic scleredema and scleroderma-like changes in a patient with maturity onset type diabetes of young people.
abstract: A 21-year-old housewife with maturity onset type diabetes of young people developed scleredema diabeticorum, scleroderma-like skin thickness on forearms and dorsum of hands, digital sclerosis and cheiroarthropathy. She had diabetes mellitus since the age of 11 years. Her grandfather on the mother's side, her mother and 3 of 5 her mother's brothers and sisters have diabetes mellitus. Blood glucose was 295 mg/dl. Urinary glucose was 5.3 g/day. Nail fold capillary microscopy revealed a progressive systemic sclerosis pattern. Histologically, hematoxylin and eosin sections from back and forearm skin demonstrated broad collagen bundles separated by widened clear spaces throughout the thickened dermis.
authors.affiliation: Department of Internal Medicine, University School of Medicine, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Kohama
authors.forename: S
authors.initials: S
authors.lastname: Houjou
authors.forename: T
authors.initials: T
authors.lastname: Iriuchijima
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: A
authors.initials: A
authors.lastname: Yamakage
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000328:Adult; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D006227:Hand Deformities, Acquired / Q000209:etiology*; D006229:Hand Dermatoses / Q000209:etiology*; D006801:Humans; D010375:Pedigree; D012592:Scleredema Adultorum / Q000209:etiology*; D012594:Scleroderma, Localized / Q000209:etiology*