Pupillary changes after intracisternal injection of papaverine.
Pupillary changes attributed to intracisternal papaverine injection were observed in three patients who underwent pterional craniotomy and clipping of a supratentorial aneurysm in which the oculomotor nerve was not manipulated. A fixed and dilated pupil on the side of the craniotomy lasted 2 to 4 hours after intracisternal papaverine instillation. These observations suggest that a dilated, nonreactive pupil subsequent to an uncomplicated pterional craniotomy for aneurysm, in which oculomotor nerve trauma has not occurred, may not be an ominous finding but may represent a transient phenomenon related to intracisternal papaverine injection.
Pritz
M B
MB
Department of Neurological Surgery, California College of Medicine, University of California Irvine Medical Center, Orange.
D000328:Adult; D000368:Aged; D002946:Cisterna Magna; D003131:Combined Modality Therapy; D006801:Humans; D007267:Injections; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage / Q000009:adverse effects*; D012025:Reflex, Pupillary / Q000187:drug effects*
D010208:Papaverine