The Bergen blood pressure study: sodium intake and ambulatory blood pressure in offspring of hypertensive and normotensive families.
Sodium intake, estimated by the 24-h urine sodium excretion, was assessed in 39 offspring of hypertensive families and 37 offspring of normotensive families. The family history of hypertension or normotension was defined according to parental BP data from two surveys conducted 27 years apart. Urine-sodium excretion was similar in offspring of hypertensive and normotensive families, averaging 136 and 137 mmol/24 h, respectively. Monitored by non-invasive methodology in the urine sampling period, the average 24-h ambulatory blood pressure (BP) was approximately 10/10 mmHg higher in offspring of hypertensive than normotensive families. The clinically and statistically significant differences in BP between groups could not be explained by differences in sodium intake. After adjustment for confounding variables, the BP was not associated with the sodium excretion in the material as a whole or in either offspring group.
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Department for Heart Diseases, University of Bergen, School of Medicine, Haukeland Hospital, Norway.
Omvik
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Lund-Johansen
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Myking
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OL
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D015924:Blood Pressure Monitors; D002648:Child; D004573:Electrolytes / Q000652:urine; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D012907:Smoking / Q000503:physiopathology; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage*
D004573:Electrolytes; D006728:Hormones; D012982:Sodium, Dietary; D012964:Sodium