title: An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease.
abstract: Previous studies demonstrated paired helical filament tau (PHF tau) in neuritic but not diffuse beta-amyloid (A beta) plaques in Alzheimer's disease (AD). Re-examination of amyloid deposits with antibodies to A beta and PHF tau by conventional and confocal microscopy using double label immunohistochemistry showed that PHF tau is a component of both diffuse and neuritic plaques in AD. Unlike controls, a dense network of PHF tau positive dystrophic neurites extended throughout the AD neocortex permeating nearly all neuritic and diffuse plaques. Thus, PHF tau-rich dystrophic neurites are common components of neuritic and diffuse plaques in AD neocortex.
authors.affiliation: Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
authors.forename: M L
authors.initials: ML
authors.lastname: Schmidt
authors.forename: A G
authors.initials: AG
authors.lastname: DiDario
authors.forename: V M
authors.initials: VM
authors.lastname: Lee
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis*; D002540:Cerebral Cortex / Q000737:chemistry* / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D016501:Neurites / Q000737:chemistry* / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000737:chemistry; D016875:tau Proteins
chemical_list: D016229:Amyloid beta-Peptides; C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D016875:tau Proteins