title: Recurrent respiratory papillomatosis: juvenile versus adult forms.
abstract: Recurrent respiratory papillomatosis (RRP) has been described to have a juvenile or aggressive form and an adult or less aggressive form. However, the aggressive form may occur in an adult and vice versa. Some authors have reported a quiescence in the juvenile form with the onset of puberty. In order to further characterize these two forms of RRP and to analyze the effects of puberty, we reviewed the records of 32 patients treated for RRP at our institution over a 10-year period. We found that the aggressive form typically occurs in the very youngest of patients (average of 2 years old as compared to an average of 17 years old in the less aggressive form). Although subglottic involvement universally occurred in our group with aggressive disease, approximately 40% developed subglottic disease very early as compared with 20% of patients with less aggressive disease. Additionally, our data do not support the theory of spontaneous regression with the onset of puberty. These and other findings will be discussed in detail. We also propose a new classification for RRP to eliminate confusion.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tulane University Medical Center, New Orleans, La 70112.
authors.forename: D J
authors.initials: DJ
authors.lastname: Doyle
authors.forename: G J
authors.initials: GJ
authors.lastname: Gianoli
authors.forename: T
authors.initials: T
authors.lastname: Espinola
authors.forename: R H
authors.initials: RH
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology*; D010212:Papilloma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D011627:Puberty; D012720:Severity of Illness Index; D009626:Terminology as Topic; D013997:Time Factors; D014140:Tracheotomy