title: Intracranial arterial occlusion associated with high-activity iodine-125 brachytherapy for glioblastoma.
abstract: We describe two patients who developed devastating strokes due to intracranial arterial occlusion 15 weeks and 97 weeks following high dose stereotactic iodine-125 brachytherapy for glioblastoma multiforme. In both cases the occlusion was within the implant volume at points receiving 110-281 Gy and there was no other evidence of significant atherosclerosis in the patients. We therefore conclude that these complications were a direct result of the brachytherapy. The phenomenon of radiation-induced occlusion of large cerebral arteries is reviewed.
authors.affiliation: Division of Neurosurgery, Toronto Hospital, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Bernstein
authors.forename: M
authors.initials: M
authors.lastname: Lumley
authors.forename: G
authors.initials: G
authors.lastname: Davidson
authors.forename: N
authors.initials: N
authors.lastname: Laperriere
authors.forename: P
authors.initials: P
authors.lastname: Leung
mesh_terms: D001157:Arterial Occlusive Diseases / Q000209:etiology*; D001918:Brachytherapy / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002539:Cerebral Arterial Diseases / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage
chemical_list: D007457:Iodine Radioisotopes