Metal ions affect neuronal membrane fluidity of rat cerebral cortex.
The effect of various metal ions on neuronal membrane fluidity was examined using 2-(14-carboxypropyl)-2-ethyl-4,4-dimethyl-3-oxazolidinyloxy, which has been used for the examination of membrane fluidity in hydrophobic areas by electron spin resonance spectrometry. Potassium, cobalt, calcium, magnesium, nickel, copper, ferric, and aluminium ions decreased the membrane fluidity while ferrous ions increased it at each high concentration. Sodium and zinc ions had no effect. Ethylenediaminetetraacetic acid decreased membrane fluidity at high concentrations. Nicardipine lowered membrane fluidity and flunarizine elevated it at each high concentration. There was no change in membrane fluidity by other calcium antagonists, nimodipine and nifedipine.
Ohba
S
S
Department of Neuroscience, Okayama University Medical School, Japan.
Hiramatsu
M
M
Edamatsu
R
R
Mori
I
I
Mori
A
A
D000818:Animals; D002412:Cations / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism*; D003497:Cyclic N-Oxides; D004492:Edetic Acid / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005444:Flunarizine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008670:Metals / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009529:Nicardipine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D009553:Nimodipine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013113:Spin Labels; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D002412:Cations; D003497:Cyclic N-Oxides; D008670:Metals; D013113:Spin Labels; D004533:Egtazic Acid; C032363:16-nitroxystearic acid; D009553:Nimodipine; D004492:Edetic Acid; D009529:Nicardipine; D009543:Nifedipine; D005444:Flunarizine