title: Chemotherapy for recurrent salivary gland malignancies: experience of the ENT Department of Turin University.
abstract: Twenty-seven patients (17 males, 10 females; median age 59 years) with recurrent high-grade malignancies of major (22 cases) and minor (5 cases) salivary gland origin (10 adenoid cystic carcinomas, 9 adenocarcinomas, 4 poorly differentiated carcinomas, 1 mixed malignant tumor, 3 mucoepidermoid carcinomas) were treated by monochemotherapy--cisplatin (CDDP) in 8 cases, or adriamycin in 5 cases--or polychemotherapy--CDDP + epirubicin + 5-fluorouracil/cyclophosphamide in 9 cases or CDDP + 5-fluorouracil in 3 cases with mucoepidermoid carcinomas. In adenocarcinoma-like tumors, patients treated by polychemotherapy showed a better response (9.1% CR, 36.3% PR) than patients treated with monochemotherapy (no CR, 23% PR). Patients with local recurrence and adenocarcinoma exhibited a better response. Median response duration: 7.5 months after poly- and 4 after monochemotherapy. Median overall survival time was 8+ months (responders: 14+) in the polychemotherapy group and 5.5 (responders: 8) in the monochemotherapy group. In the 3 cases with mucoepidermoid carcinoma 1 patient achieved a PR (33.3%) and in 2 there was no change.
authors.affiliation: Department of Medical Oncology, Turin University, Ospedale Molinette, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Airoldi
authors.forename: V
authors.initials: V
authors.lastname: Brando
authors.forename: C
authors.initials: C
authors.lastname: Giordano
authors.forename: P
authors.initials: P
authors.lastname: Gabriele
authors.forename: M
authors.initials: M
authors.lastname: Bussi
authors.forename: G
authors.initials: G
authors.lastname: Cortesina
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012468:Salivary Gland Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin