title: Host control of yeast dsRNA virus propagation and expression.
abstract: Yeast controls propagation of the L-A dsRNA virus, and thus pathogenicity, by partially blocking translation of viral mRNA. L-A makes a Gag-Pol fusion protein by a -1 ribosomal frameshift, regulated by the host but critical for satellite RNA propagation. Discovery of the KEX proteases, by their requirement for killer toxin expression from a satellite dsRNA of L-A, led to the identification of mammalian prohormone processing proteases.
authors.affiliation: Section on Genetics of Simple Eukaryotes, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
authors.forename: R B
authors.initials: RB
authors.lastname: Wickner
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics; D005814:Genes, Viral; D043484:Proprotein Convertases; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012328:RNA Viruses / Q000502:physiology*; D012330:RNA, Double-Stranded / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D013381:Subtilisins / Q000235:genetics; D015003:Yeasts / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D012330:RNA, Double-Stranded; D029701:Saccharomyces cerevisiae Proteins; D043484:Proprotein Convertases; D013381:Subtilisins; C058751:KEX2 protein, S cerevisiae