MHC class II antigen processing: biology of invariant chain.
The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, regulation of Ii synthesis, post-transcriptional events, and post-translational modification has the potential to dramatically modulate immune responses.
Sant
A J
AJ
Department of Pathology, University of Chicago, Illinois 60637.
Miller
J
J
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte; D002809:Chondroitin Sulfates / Q000502:physiology; D004705:Endocytosis / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000276:immunology; D011485:Protein Binding; D011499:Protein Processing, Post-Translational
D000944:Antigens, Differentiation, B-Lymphocyte; D000949:Histocompatibility Antigens Class II; D010455:Peptides; C045084:invariant chain; D002809:Chondroitin Sulfates