title: Serious group A beta-hemolytic streptococcal infections complicating varicella.
abstract: OBJECTIVE
  To alert practicing emergency physicians to an important and possibly increasing relationship between life-threatening group A beta-hemolytic streptococcal (GABHS) infections and children recovering from varicella.
  
  
  METHODS
  A case series of six patients managed from January through March 1993.
  
  
  METHODS
  A university-affiliated pediatric specialty emergency department.
  
  
  METHODS
  Six previously healthy immunocompetent children between 1 and 5 years of age seen in our ED over a nine-week period.
  
  
  RESULTS
  Six children had onset of varicella two days to two weeks before developing a serious life-threatening GABHS infection. Children presented with clinical symptoms of invasive GABHS infection with bacteremia (one patient); streptococcal toxic shock syndrome with negative blood culture (two), pneumonia with pleural effusion and streptococcal toxic shock syndrome (one), pneumonia with pleural effusion (one), and pyomyositis of the thigh (one). Four of six patients required intensive care admissions and aggressive support of vital signs. All six survived.
  
  
  CONCLUSIONS
  Emergency physicians should be aware of the association between varicella and serious GABHS infections and be prepared to recognize and aggressively manage serious complications should they occur.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas.
authors.forename: M R
authors.initials: MR
authors.lastname: Cowan
authors.forename: P A
authors.initials: PA
authors.lastname: Primm
authors.forename: S M
authors.initials: SM
authors.lastname: Scott
authors.forename: T J
authors.initials: TJ
authors.lastname: Abramo
authors.forename: R A
authors.initials: RA
authors.lastname: Wiebe
mesh_terms: D002481:Cellulitis / Q000150:complications / Q000382:microbiology; D002644:Chickenpox / Q000150:complications*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003422:Critical Care; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000150:complications / Q000382:microbiology*; D013290:Streptococcal Infections / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D013297:Streptococcus pyogenes