Phospholipases and protein kinases during phagocyte activation.
Phospholipases and protein kinases are critical for the intracellular transmission and amplification of signals induced by extracellular ligands. Chemotactic activation of phagocytes through G protein coupled receptors leads to inflammatory responses of the immune cells. Downstream of G proteins, phospholipases generate precursors for eicosanoid synthesis and are involved in the functional responses. Recently, the molecular characterization of specific enzymes of the signalling cascades has gained much attention in research.
Thelen
M
M
Theodor Kocher Institute, University of Bern, Switzerland.
Wirthmueller
U
U
D000818:Animals; D006801:Humans; D010586:Phagocytes / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D010740:Phospholipases / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction
D011494:Protein Kinases; D010740:Phospholipases