title: [Subacute toxicity of triphenyltin acetate (TPTA) in the rabbit: clinical observations and hematologic, hematochemical and enzymatic changes].
abstract: Twenty-eight immature male rabbits were divided into four experimental groups and administered a standard diet containing respectively 0, 15, 75 and 150 ppm of triphenyltin acetate (TPTA) for 70 days. The highest dose group showed a decrease in erythrocyte count, haemoglobin content and packed cell volume. As early as on day 35, leucopenia and lymphopenia were recorded in all treated groups, thereby confirming the well-known immunosuppressive activity of organo-tin compounds. Both total serum protein and albumin levels apparently altered by TPTA treatment. Conversely, there was a dose-dependent increase for both alpha 2-globulin fraction and blood urea nitrogen serum levels, suggesting a possible renal involvement.
authors.affiliation: Dipartimento di Patologia Animale, Università di Torino.
authors.forename: M
authors.initials: M
authors.lastname: Dacasto
authors.forename: O
authors.initials: O
authors.lastname: Abate
authors.forename: C
authors.initials: C
authors.lastname: Nebbia
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001798:Blood Proteins / Q000187:drug effects; D001806:Blood Urea Nitrogen; D005659:Fungicides, Industrial / Q000633:toxicity*; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D011817:Rabbits / Q000097:blood*
chemical_list: D001798:Blood Proteins; D005659:Fungicides, Industrial; D009947:Organotin Compounds; C011978:phentin acetate
vernacular_title: Tossicità subacuta dell'acetato di trifenil-stagno (TPTA) nel coniglio: osservazioni cliniche ed alterazioni ematologiche, ematochimiche ed enzimatiche.