[The evolution of the clinical activity of systemic lupus erythematosus after a kidney transplant].
BACKGROUND
To study the clinical activity of systemic lupus erythematosus (SLE) in recipients of renal transplants (rT) performed by terminal renal failure (TRF) secondary to lupus nephritis.


METHODS
The clinical evolution of 11 patients with SLE (ARA criteria) and TRF were evaluated with a descriptive character by the modified index of activity SLE-DAI during dialysis periods and post rT as well as in the course prior to disease. A comparative analysis was carried out in a control group of 25 patients with SLE without renal failure.


RESULTS
The indexes of activity of the group investigated were higher than those of the control group during the predialysis period, similar in the dialysis period and significantly decreased (p < 0.01) in the post rT. In the group with rT a significant decrease was reported in the indexes of activity in the periods of dialysis (p < 0.05) and post rT (p < 0.01) with respect to the previous period. A significant reduction was observed in the post rT therapeutic options.


CONCLUSIONS
The clinical activity of systemic lupus erythematosus is reduced in the terminal renal failure in dialysis. The most significant reduction of clinical activity is found after renal transplantation.
Hernández-Beriaín
J A
JA
Servicio de Reumatología, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, Santa Cruz de Tenerife.
González
T
T
Bustabad
S
S
Gantes
M
M
Rodríguez-Lozano
B
B
D000328:Adult; D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D008181:Lupus Nephritis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D006435:Renal Dialysis / Q000706:statistics & numerical data
Evolución de la actividad clínica del lupus eritematoso sistémico postrasplante renal.