title: A novel method of measuring the concentration of anaesthetic vapours using a dew-point hygrometer.
abstract: The Antoine equation relates the saturated vapour pressure of a volatile substance, such as an anaesthetic agent, to the temperature. The measurement of the 'dew-point' of a dry gas mixture containing a volatile anaesthetic agent by a dew-point hygrometer permits the determination of the partial pressure of the anaesthetic agent. The accuracy of this technique is limited only by the accuracy of the Antoine coefficients and of the temperature measurement. Comparing measurements by the dew-point method with measurements by refractometry showed systematic discrepancies up to 0.2% and random discrepancies with SDS up to 0.07% concentration in the 1% to 5% range for three volatile anaesthetics. The systematic discrepancies may be due to errors in available data for the vapour pressures and/or the refractive indices of the anaesthetics.
authors.affiliation: Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Cardiff, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Wilkes
authors.forename: W W
authors.initials: WW
authors.lastname: Mapleson
authors.forename: J S
authors.initials: JS
authors.lastname: Mecklenburgh
mesh_terms: D000769:Anesthesia, Inhalation; D004737:Enflurane; D006221:Halothane; D006801:Humans; D007530:Isoflurane; D008722:Methods; D010313:Partial Pressure; D012031:Refractometry; D014835:Volatilization
chemical_list: D004737:Enflurane; D007530:Isoflurane; D006221:Halothane