[Synthesis of antibiotic-glycoside conjugates as potential ligands for bacterial lectins].
Conjugates were prepared from penicillins (ampicillin, amoxicillin) and carbohydrates (mannose, glucose). Only the mannose containing conjugates bind specifically to the fimbriae of mannose sensitive Escherichia coli cells. A significant decrease in the minimal inhibiting concentration of the conjugate toward the bacteria as compared to the starting penicillin could not be observed.
Hetfleisch-Stephan
J
J
Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg.
Schunk
A
A
Rüdiger
H
H
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000138:chemical synthesis*; D001419:Bacteria / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D005947:Glucose / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis*; D007769:Lactams; D037102:Lectins / Q000737:chemistry*; D008024:Ligands; D008358:Mannose / Q000737:chemistry; D010406:Penicillins / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D000900:Anti-Bacterial Agents; D006027:Glycosides; D007769:Lactams; D037102:Lectins; D008024:Ligands; D010406:Penicillins; D005947:Glucose; D008358:Mannose
Synthese von Antibiotika-Glycosid-Konjugaten als potentiellen Liganden für Bakterienlectine.