title: A longitudinal study of human papillomavirus DNA detection in human immunodeficiency virus type 1-seropositive and -seronegative women.
abstract: Cericovaginal lavage samples from 124 human immunodeficiency virus type 1 (HIV-1)-seropositive and 126 HIV-1-seronegative women were collected monthly for 8 months and tested for human papillomavirus (HPV) DNA. The estimated prevalence of HPV was 42.8% in HIV-1-seropositive and 13.4% in -seronegative women (P < .001). There was no significant difference in HPV DNA detection in HIV-1-seropositive women with CD4 cell counts of < 300/mm3 (50% HPV-positive), 300-499/mm3 (36.4% HPV-positive), or > or = to 500/mm3 (40.5% HIV-positive). However, HIV-1-seropositive women who were more immunocompromised, as indicated by lower CD4 cell counts, were more likely to shed HPV persistently. The quantity of HPV DNA detected in cervicovaginal lavage samples was similar in HIV-1-seropositive and -seronegative women. This study further defined the characteristics of HPV infections in HIV-1-infected women.
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
authors.forename: S D
authors.initials: SD
authors.lastname: Vernon
authors.forename: W C
authors.initials: WC
authors.lastname: Reeves
authors.forename: K A
authors.initials: KA
authors.lastname: Clancy
authors.forename: M
authors.initials: M
authors.lastname: Laga
authors.forename: M
authors.initials: M
authors.lastname: St Louis
authors.forename: H E
authors.initials: HE
authors.lastname: Gary
authors.forename: R W
authors.initials: RW
authors.lastname: Ryder
authors.forename: A T
authors.initials: AT
authors.lastname: Manoka
authors.forename: J P
authors.initials: JP
authors.lastname: Icenogle
mesh_terms: D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008137:Longitudinal Studies; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D014621:Vagina / Q000821:virology
chemical_list: D004279:DNA, Viral