The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice.
B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies.
Eisenberg
R A
RA
Department of Medicine, University of North Carolina at Chapel Hill 27599-7280.
Sobel
E S
ES
Reap
E A
EA
Halpern
M D
MD
Cohen
P L
PL
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002454:Cell Differentiation; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D018183:Transplantation Chimera
D001323:Autoantibodies