Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
Grabstein
K H
KH
Immunex Research and Development Corporation, Seattle, WA 98101.
Eisenman
J
J
Shanebeck
K
K
Rauch
C
C
Srinivasan
S
S
Fung
V
V
Beers
C
C
Richardson
J
J
Schoenborn
M A
MA
Ahdieh
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D000882:Haplorhini; D006801:Humans; D019409:Interleukin-15; D007376:Interleukin-2 / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D007378:Interleukins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D019409:Interleukin-15; D007376:Interleukin-2; D007378:Interleukins; D015375:Receptors, Interleukin-2