Diagnosis and management of von Willebrand's syndrome.
von Willebrand's disease is the most common of the inherited bleeding disorders. It is caused by quantitative and/or qualitative abnormalities of von Willebrand factor, and it usually presents with bleeding from mucosal surfaces. The diagnosis is confirmed by measuring von Willebrand factor activity and antigen levels, factor VIII activity, and performing a multimer analysis of von Willebrand factor. Treatment may require plasma-derived concentrates, but can often be accomplished with DDAVP, a vasopressin analogue that causes transient release of von Willebrand factor from body storage sites.
Rick
M E
ME
Hematology Service, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD.
D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D006801:Humans; D014842:von Willebrand Diseases / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy*; D014841:von Willebrand Factor / Q000737:chemistry / Q000502:physiology
D014841:von Willebrand Factor; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin