Regulation of intracellular calcium in cardiac muscle.
We have investigated the regulation of intracellular free calcium in heart muscle using the free acid form of the Ca2+ indicator fura-2 iontophoretically microinjected into rat cardiac trabeculae or ferret papillary muscles. This method shows great promise in elucidating a number of crucial questions in cardiac excitation-contraction coupling.
Backx
P H
PH
Department of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Gao
W D
WD
Azan-Backx
M D
MD
Marban
E
E
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005289:Ferrets; D016257:Fura-2; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D002118:Calcium; D016257:Fura-2