Mouse Ly-gene haplotypes and subcutaneous regression of Ehrlich ascites tumor.
Ehrlich ascites tumor cells (EAT cells) lack most cell surface H-2 antigens and grow in any mouse strain following intraperitoneal injection of 10(5) cells. With subcutaneous injection of 2 x 10(7) cells, however, EAT regressed in C57BL/10 (H-2b), BALB/c (H-2d), NZB (H-2d), A (H-2a) and SJL (H-2s) but progressed and formed a solid tumor in DBA/2 (H-2d), C3H (H-2k), AKR (H-2k), CBA (H-2k) and DBA/1 (H-2q). By genotype analysis, Ly haplotypes of EAT-regressive mouse strains were found to have Ly-1.2 and Ly-2.2 as common features, while EAT-progressive mouse strains had Ly-1.1 (except AKR) and Ly-2.1.
Sato
N L
NL
Institute for Laboratory Animals, Niigata University School of Medicine, Japan.
Kato
A
A
Fujisawa
N
N
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D000951:Antigens, Neoplasm / Q000235:genetics; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics* / Q000473:pathology; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics*; D009368:Neoplasm Transplantation
D000950:Antigens, Ly; D000951:Antigens, Neoplasm; D006183:H-2 Antigens