Effects of diet restriction and carnitine on carbon tetrachloride toxicity in the rat.
Male Sprague Dawley rats were fed a semisynthetic diet ad libitum, 55% of ad libitum (45% restriction), or supplemented with 1% L-carnitine for 68 days. The LD50 dose of CCl4 was orally administered, and mortality and hepatic lipids were determined. The CCl4-induced mortality was significantly increased by feed restriction but not by carnitine. Carnitine prevented hepatic lipid accumulation caused by CCl4 under these conditions.
Sachan
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DS
Department of Nutrition, Human Ecology, Univ. of Tennessee, Knoxville 37996-1900.
Berger
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D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D002331:Carnitine / Q000008:administration & dosage*; D005508:Food Deprivation; D005527:Food, Fortified; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate
D008055:Lipids; D002331:Carnitine