title: Ultrasonographic abdominal screening of atomic bomb-exposed subjects.
abstract: Abdominal ultrasonographic screening for cancer was performed in 6,001 Hiroshima and Nagasaki A-bomb exposed and comparison subjects, all members of the Adult Health Study of the Radiation Effects Research Foundation, formerly the Atomic Bomb Casualty Commission. This study yielded 20 cancers, including 7 hepatocellular, 3 gastric, 3 renal and 2 urinary bladder cancers; one cancer each of the ovary, pancreas, colon and ureter; and one cancer metastatic to the liver, whose primary was unknown. Seventeen of these 20 subjects manifested no symptoms or signs of their disease. A variety of additional tumors, unproven and probably benign, including uterine myomata, and other abnormalities were also detected. Abdominal ultrasonographic screening greatly assisted in the detection of cancers, most of which neither the patients nor their physicians were aware. In this screened fixed population sample the cancer detection rate was 0.33%, exceeding any such rates previously reported in the medical literature.
authors.affiliation: Department of Clinical Studies and Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authors.forename: W J
authors.initials: WJ
authors.lastname: Russell
authors.forename: Y
authors.initials: Y
authors.lastname: Higashi
authors.forename: T
authors.initials: T
authors.lastname: Fukuya
authors.forename: Y
authors.initials: Y
authors.lastname: Hosoda
authors.forename: J
authors.initials: J
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Kawashima
authors.forename: S
authors.initials: S
authors.lastname: Murayama
authors.forename: T
authors.initials: T
authors.lastname: Ohuchida
authors.forename: F
authors.initials: F
authors.lastname: Mihara
authors.forename: M
authors.initials: M
authors.lastname: Takagi
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging*; D009689:Nuclear Warfare; D013534:Survival; D014463:Ultrasonography