[Comparative study and morphometrical analysis of the in vivo invasiveness of mouse lung adenocarcinoma variants with different metastatic potentials].
The in vivo invasiveness of LA1, LAD and LA5 variants of mouse lung adenocarcinoma (LA795) with different metastatic potentials was studied comparatively. The in vivo invasive abilities of LA1, LAD and LA5 were surveyed after subrenal capsule inoculation of a 1-nm3 tumor fragment of the respective variant. The morphometrical study included measurement of the whole tissue section area (TA), tumor tissue area (SA) and SA/TA (indicating tumor invasion ability). The results of histological observation were in accordance with those of morphometrical measurement. The invasion was found to be progressive, with a progressively enlarging tumor invasion area and an increasing SA/TA ratio in all cases. The invasiveness of LA1, LAD and LA5 in vivo was correlated with metastatic potential.
Liu
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Institute of Basic Medical Sciences, CAMS, Beijing.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D007091:Image Processing, Computer-Assisted; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D009361:Neoplasm Invasiveness; D013370:Subrenal Capsule Assay; D014407:Tumor Cells, Cultured