Measurement of dead-space in a model lung using an oscillating inspired argon signal.
In a model lung, airways dead-space can be accurately measured using a forced inspired oscillating argon signal, which varies sinusoidally about a mean concentration of 6% v/v with an amplitude of +/- 4% v/v. With sinusoid forcing periods longer than 120 seconds, and at a breathing rate of 13.4 breaths minute-1, the mean airways dead-space can be measured with a standard error of less than 5%. Sinusoid forcing periods shorter than 120 s provided inaccurate estimates of dead-space and so should not be used with this technique.
Williams
E M
EM
Nuffield Department of Anaesthetics, University of Oxford, UK.
Gavaghan
D J
DJ
Oakley
P A
PA
Sainsbury
M C
MC
Xiong
L
L
Black
A M
AM
Hahn
C E
CE
D001128:Argon; D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D009991:Oscillometry; D010313:Partial Pressure; D011650:Pulmonary Alveoli / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology; D012119:Respiration / Q000502:physiology; D012126:Respiratory Dead Space; D013990:Tidal Volume / Q000502:physiology; D014692:Ventilation-Perfusion Ratio
D001128:Argon