title: An experimental study of cefixime in the treatment of Streptococcus pneumoniae otitis media.
abstract: Previous studies using the chinchilla animal model demonstrated that the third generation cephalosporin cefixime (Suprax) with split dosing was as effective as ampicillin in sterilizing the middle ear cleft when infected with S. pneumoniae. In this investigator-blinded, randomized trial, a single daily dose of cefixime (8 mg/kg per day) performed as well as split dosing of cefixime (8 mg/kg every 8 h) and ampicillin (150 mg/kg every 8 h) in the time to sterilization of the middle ear cleft. No statistically significant differences were noted between groups in otoscopy or tympanometry. All antibiotic regimens performed better than saline control (P < 0.0001) with regard to time to sterilization of the middle ear cleft. The results of this study support the daily administration of cefixime as an effective agent for the treatment of otitis media due to its extended half-life and broad antibiotic spectrum.
authors.affiliation: Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, PA 15213-2583.
authors.forename: A E
authors.initials: AE
authors.lastname: Magit
authors.forename: J N
authors.initials: JN
authors.lastname: Dolitsky
authors.forename: W J
authors.initials: WJ
authors.lastname: Doyle
authors.forename: J D
authors.initials: JD
authors.lastname: Swarts
authors.forename: J T
authors.initials: JT
authors.lastname: Seroky
authors.forename: R M
authors.initials: RM
authors.lastname: Rosenfeld
mesh_terms: D000158:Acoustic Impedance Tests; D000208:Acute Disease; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D020682:Cefixime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D002682:Chinchilla; D004432:Ear, Middle / Q000382:microbiology / Q000473:pathology; D004724:Endoscopy; D007273:Injections, Intramuscular; D010033:Otitis Media / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D010919:Placebos; D011008:Pneumococcal Infections / Q000188:drug therapy*; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D010919:Placebos; D000667:Ampicillin; D020682:Cefixime; D002439:Cefotaxime