title: Nonpalpable breast tumors: diagnosis with contrast-enhanced subtraction dynamic MR imaging.
abstract: OBJECTIVE
  To determine the accuracy of contrast material-enhanced subtraction dynamic magnetic resonance (MR) imaging in the diagnosis of nonpalpable breast tumors.
  
  
  METHODS
  One hundred forty-three patients underwent surgical biopsy of a nonpalpable breast lesion. Their mammograms showed microcalcifications (n = 80), opacity (n = 52), architectural distortion (n = 10), or asymmetric density (n = 1). All patients underwent a preoperative gadolinium tetraazacyclododecanetetraacetic acid-enhanced subtraction dynamic study. Any early contrast enhancement in the breast parenchyma was considered pathologic.
  
  
  RESULTS
  At histologic analysis, 27 intraductal carcinomas, 37 invasive carcinomas, and 79 benign lesions were found. Dynamic MR studies showed early contrast enhancement in 61 of 64 breast cancers (sensitivity, 95%) and in 37 of 79 benign lesions (specificity, 53%). Two invasive lobular carcinomas and one tubular carcinoma showed no early contrast enhancement.
  
  
  CONCLUSIONS
  Subtraction dynamic MR imaging may be helpful to rule out malignancy in nonpalpable breast tumors.
authors.affiliation: Department of Radiology, Institut Gustave Roussy, Villejuif, France.
authors.forename: R
authors.initials: R
authors.lastname: Gilles
authors.forename: J M
authors.initials: JM
authors.lastname: Guinebretière
authors.forename: O
authors.initials: O
authors.lastname: Lucidarme
authors.forename: P
authors.initials: P
authors.lastname: Cluzel
authors.forename: G
authors.initials: G
authors.lastname: Janaud
authors.forename: J F
authors.initials: JF
authors.lastname: Finet
authors.forename: A
authors.initials: A
authors.lastname: Tardivon
authors.forename: J
authors.initials: J
authors.lastname: Masselot
authors.forename: D
authors.initials: D
authors.lastname: Vanel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D006571:Heterocyclic Compounds; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008875:Middle Aged; D015588:Observer Variation; D009942:Organometallic Compounds; D010173:Palpation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate