Thioridazine enantiomers in human tissues.
Enantiomers of thioridazine (TRZ) were determined in postmortem tissues obtained from a patient on chronic TRZ therapy by sequential achiral and chiral high pressure liquid chromatography. Tissue concentrations of (+)-TRZ found in liver, brain, bile and blood were: 6.46, 0.40, 0.48 and 0.07 mg/l or mg/kg, respectively. Concentrations of (-)-TRZ in liver, brain, bile and blood were: 12.2, 0.81, 1.07 and 0.20 mg/l or mg/kg, respectively. These data demonstrate the stereoselective disposition of TRZ in human tissues.
Jortani
S A
SA
Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0597.
Valentour
J C
JC
Poklis
A
A
D000328:Adult; D001826:Body Fluids / Q000737:chemistry; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005473:Fluoxetine / Q000032:analysis; D006801:Humans; D008099:Liver / Q000737:chemistry; D011180:Postmortem Changes; D013405:Suicide; D013881:Thioridazine / Q000032:analysis*
D005473:Fluoxetine; D013881:Thioridazine