title: Combined therapy of granulocyte transfusions, intravenous opsonins and antibiotics for gram-negative pneumonia in neutropenic cancer patients.
abstract: Four patients with hematological malignancies, following bone marrow transplantation, who developed documented gram-negative [Klebsiella pneumoniae (2), Pseudomonas aeruginosa or Acinetobacter calcoaceticus] pneumonia during absolute neutropenia, were treated with a combination of antimicrobial therapy, granulocyte transfusions, and high-dose intravenous immunoglobulin. The patients recovered following this regimen, including 2 who had septic shock and respiratory failure, necessitating intubation and mechanical ventilation. These data suggest that therapy combining antimicrobial agents, granulocyte transfusions and opsonins may be effective in neutropenic patients who develop gram-negative pneumonia.
authors.affiliation: Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.forename: E
authors.initials: E
authors.lastname: Naparstek
authors.forename: D
authors.initials: D
authors.lastname: Engelhard
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000209:etiology / Q000628:therapy*; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D009503:Neutropenia / Q000150:complications* / Q000628:therapy; D009895:Opsonin Proteins / Q000008:administration & dosage*; D011014:Pneumonia / Q000209:etiology / Q000628:therapy*; D012074:Remission Induction
chemical_list: D000900:Anti-Bacterial Agents; D009895:Opsonin Proteins