B-cell lymphoma following polycythemia vera: evidence for the involvement of two different clones.
We report here two patients with polycythemia vera (PV) who developed secondary non-Hodgkin's lymphoma (NHL). Both cases were high grade B-cell NHL. Cytogenetic analysis of bone marrow and lymph node was performed in each case and showed numerous chromosomal abnormalities. Of interest, chromosomal abnormalities of the PV and of the NHL clones were different, suggesting the possible involvement of two different clones. A 11q23 breakpoint was common between the two cases and the putative role of this breakpoint in the pathogenesis of the NHLs is discussed.
Schlaifer
D
D
Department of Hematology, Hôpital de Purpan, Toulouse, France.
Dastugue
N
N
Brousset
P
P
Delsol
G
G
Muller
C
C
Rigal-Huguet
F
F
Attal
M
M
Laurent
G
G
Pris
J
J
D000368:Aged; D002869:Chromosome Aberrations; D002873:Chromosome Fragility; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics* / Q000473:pathology