[Laser speckle velocimetry of retinal blood flow with simultaneous measurement of retinal vessel diameter].
A new retinal blood flowmeter, by which the real-time measurement of retinal vessel diameter and laser speckle retinal blood flow velocimetry could be performed simultaneously, was developed and the reproducibility of the measurements was studied for 16 retinal veins of 8 eyes (4 normal volunteers). The experiment was performed on all veins measured three times in 2 days. The first 2 measurements were performed on the first day at an interval of about 2 hours and the third measurement was performed on the second day. The result of each measurement was compared with the others. The reproducibility of retinal blood flow velocity measurements was 5.53 +/- 2.15% (mean +/- standard deviation) in coefficient of variation (CV), that of blood vessel diameter measurements was 3.06 +/- 1.58% in CV, and that of blood flow measurement was 5.54 +/- 2.10% in CV. The fluctuation between the three measured data was 10.50 +/- 7.25% (mean +/- standard deviation), 10.01 +/- 6.98%, 11.60 +/- 6.47% in the retinal blood flow velocity measurements, 6.34 +/- 4.40%, 5.71 +/- 4.49%, 4.46 +/- 4.36% in the retinal blood vessel diameter measurements, and 6.59 +/- 8.36%, 10.76 +/- 8.91%, 9.72 +/- 4.42% in the retinal blood flow measurements. This method enabled more precise measurement of the retinal blood flow than previously reported methods.
Suzuki
Y
Y
Department of Ophthalmology, Kanto-Teishin Hospital, Japan.
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D007834:Lasers; D012171:Retinal Vessels / Q000033:anatomy & histology* / Q000502:physiology*; D012542:Scattering, Radiation