Antisense oligonucleotides as antiviral agents: prospects and problems.
One possible strategy for the development of antiviral drugs is to synthesize short antisense oligonucleotides that interfere specifically with RNA transcription and processing to prevent expression of protein. This can be readily achieved, but there are formidable technical problems to solve before routine clinical applications can be envisaged.
Cantin
E M
EM
Dept of Neurology, City of Hope National Medical Center, Duarte, CA 91010.
Woolf
T M
TM
D000998:Antiviral Agents / Q000494:pharmacology*; D016376:Oligonucleotides, Antisense / Q000493:pharmacokinetics / Q000494:pharmacology*
D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense