Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6.
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor alpha (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. The genes are closely linked, with 0/215 recombinants between Anx4 and Tgfa and 1/215 recombinants between these genes and Egr4. The genes are located approximately 2 cM distal to mnd2, a mouse mutation causing neuromuscular disease. The results demonstrate that mnd2 is located at an internal position within this conserved linkage group.
Barrow
L L
LL
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618.
Simin
K
K
Jones
J M
JM
Lee
D C
DC
Meisler
M H
MH
D000818:Animals; D017314:Annexin A4 / Q000235:genetics*; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D051379:Mice / Q000235:genetics*; D009468:Neuromuscular Diseases / Q000235:genetics; D011995:Recombination, Genetic; D014157:Transcription Factors / Q000235:genetics*; D016211:Transforming Growth Factor alpha / Q000235:genetics*; D016335:Zinc Fingers
D017314:Annexin A4; D014157:Transcription Factors; D016211:Transforming Growth Factor alpha