Restin in Hodgkin's disease and anaplastic large cell lymphoma.
We recently characterized a novel putative intermediate-filament associated protein which is strongly expressed in the Reed-Sternberg cells of Hodgkin's disease. Therefore we named the protein 'restin', an acronym for Reed-Sternberg cell intermediate filament-associated protein. The protein is also expressed in anaplastic large cell lymphoma or Ki-1 lymphoma, a non-Hodgkin's lymphoma phenotypically related to Hodgkin's disease. Although the functions of restin are not yet fully elucidated, transfection experiments demonstrate that overexpression of the protein increases cell growth by a mechanism which may involve upregulation of the transferrin receptor. Hence, restin may contribute to neoplastic transformation in Hodgkin's disease and anaplastic large cell lymphoma. Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma.
Delabie
J
J
Laboratory of Histo- and Cytochemistry, University of Leuven, Belgium.
Bilbe
G
G
Brüggen
J
J
Van Leuven
F
F
De Wolf-Peeters
C
C
D002471:Cell Transformation, Neoplastic; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D016539:Reed-Sternberg Cells / Q000473:pathology*
D007381:Intermediate Filament Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; C076744:cytoplasmic linker protein 170