title: Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.
abstract: Cyclic nucleotide-gated cation channels are essential in visual and olfactory signal transduction. An additional member of the cGMP-gated channel family, termed CNG-3, has been cloned from bovine kidney. Its deduced amino acid sequence is 60% and 62% identical with the CNG-channel proteins from bovine rod outer segment and bovine olfactory epithelium, respectively. Northern analysis and sequences amplified by the PCR showed that the CNG-3 mRNA is present in testis, kidney, and heart. Calcium permeated the expressed channel in the presence of extracellular Mg2+ and Na+ at membrane potentials from -100 to +45 mV. It is likely that CNG-3 protein is responsible for cGMP-induced Ca2+ entry in cells other than sensory cells.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Technischen Universität München, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Biel
authors.forename: X
authors.initials: X
authors.lastname: Zong
authors.forename: M
authors.initials: M
authors.lastname: Distler
authors.forename: E
authors.initials: E
authors.lastname: Bosse
authors.forename: N
authors.initials: N
authors.lastname: Klugbauer
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: V
authors.initials: V
authors.lastname: Flockerzi
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
mesh_terms: D000818:Animals; D001483:Base Sequence; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000235:genetics*; D002417:Cattle; D003001:Cloning, Molecular; D015640:Ion Channel Gating; D007668:Kidney / Q000502:physiology; D008969:Molecular Sequence Data; D009712:Nucleotides, Cyclic / Q000502:physiology; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D015220:Calcium Channels; D009712:Nucleotides, Cyclic; D009838:Oligodeoxyribonucleotides; D002118:Calcium