title: [The protective properties of the outer membranes of Francisella tularensis in an experimental infection in guinea pigs].
abstract: Subcutaneous immunization, made in a single injection, with outer membrane preparations obtained from F.tularensis vaccine strain 15 and virulent strain A'Cole results in intensive immunity to tularemia in guinea pigs, ensuring the protection of 60-100% of the animals within a month after challenge with F.tularensis virulent strain 503 in a dose of 1,000 DCL. The development of protective effect induced by F.tularensis outer membranes can be observed during the first 24 hours and reaches its maximum by days 15-21 after immunization.
authors.forename: V S
authors.initials: VS
authors.lastname: Khlebnikov
authors.forename: I R
authors.initials: IR
authors.lastname: Golovlev
authors.forename: A M
authors.initials: AM
authors.lastname: Chugunov
authors.forename: V E
authors.initials: VE
authors.lastname: Zhemchugov
authors.forename: S F
authors.initials: SF
authors.lastname: Averin
authors.forename: S S
authors.initials: SS
authors.lastname: Afanas'ev
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Pshirkov
authors.forename: S I
authors.initials: SI
authors.lastname: Konovalov
authors.forename: A V
authors.initials: AV
authors.lastname: Stepanov
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D006168:Guinea Pigs; D007114:Immunization; D013997:Time Factors; D014406:Tularemia / Q000401:mortality / Q000517:prevention & control*; D014774:Virulence
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Zashchitnye svoĭstva vneshnykh membran Francisella tularensis pri éksperimental'noĭ infektsii morskikh svinok.