[The participation of adrenoreceptors in regulating dominant behavior and gonadal endocrine function in male mice of different genotypes].
Dominant behaviour and testosterone level were investigated after adrenoreceptor (AR) blocking drugs injections in PT and CBA/Lac mice predisposed, correspondingly, to dominant and subordinate behaviour in a population and their hybrids F1. Phentolamine (alpha-AR blocker, 1 mg/kg) or obsidan (beta-AR blocker, 1 mg/kg) injections resulted in a loss of the dominant rank of CBA/Lac mice and did not affect the PT mice behaviour. Higher doses (2 and 5 mg/kg) were also ineffective. Simultaneous phentolamine and obsidan injections (1 mg/kg) caused a dominant phenotype inversion, decrease of aggression and testosterone level in PT mice. F1 inherited an ability to dominate in a population and a sensitivity of AR form PT inbred strain. Their behaviour and endocrine characteristics after injections of AR-blockers were close to those of PT mice.
Serova
L I
LI
Zhukova
A V
AV
Kozlova
O N
ON
Naumenko
E V
EV
D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004291:Dominance-Subordination; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D011941:Receptors, Adrenergic; D013739:Testosterone; D011433:Propranolol; D010646:Phentolamine
Uchastie adrenoretseptorov v reguliatsii dominantnogo povedeniia i éndokrinnoĭ funktsii gonad u samtsov mysheĭ raznykh genotipov.