Hyperchloremic acidosis during grand mal seizure lactic acidosis.
OBJECTIVE
To evaluate the prevalence and the mechanism of hyperchloremic acidosis component (HClA) during lactic acidosis secondary to grand mal seizures.


METHODS
Retrospective study.


METHODS
Medical intensive care unit in a university hospital.


METHODS
35 patients admitted for grand mal seizures with lactic acidosis (pH < 7.35, TCO2 < 20 mmol/l and PaCO2 < 8 kPa).


METHODS
HClA was defined by the ratio: excess anion gap/HCO3 deficit (delta AG/delta TCO2) < 0.8. A difference in the distribution space of protons and their accompanying anion, i.e., a displacement of chloride from cells by the entering lactate, was evaluated by the ratio natremia/chloremia (Na+/Cl-).


RESULTS
Immediately after seizures, a profound lactic acidosis was observed (pH = 7.22 +/- 0.17 (mean +/- SD), AG: 23.8 +/- 7.1 mmol/l, TCO2 = 14.5 +/- 5.3 mmol/l, lactate: 14.6 +/- 6.9 mmol/. HClA was present on admission in 11 patients (31.5%). Its prevalence increased to 73% after recovery. delta AG/delta TCO2 ratios were unrelated to creatinine, level and PaCO2, but dependent on the ratio Na+/Cl- (r = 0.803; p < 0.001, delta AG/delta TCO2 = 6.4 x (Na+/Cl-)-7.9). These data demonstrate that HClA is not a respiratory or renal phenomenon and suggest differences in the distribution spaces of hydrogen ions and their accompanying anions.


CONCLUSIONS
HClA component may be associated with lactic acidosis in grand mal seizures and appears to be secondary to a lactate antiport. This phenomenon could be an immediate physiological response to a sudden metabolic acidosis.
Brivet
F
F
Intensive Care Unit, Hôpital Antoine Béclère, Clamart, France.
Bernardin
M
M
Cherin
P
P
Chalas
J
J
Galanaud
P
P
Dormont
J
J
D000136:Acid-Base Equilibrium; D000140:Acidosis, Lactic / Q000097:blood / Q000453:epidemiology; D000208:Acute Disease; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D002712:Chlorides / Q000097:blood*; D004830:Epilepsy, Tonic-Clonic / Q000097:blood* / Q000453:epidemiology; D005110:Extracellular Space / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012189:Retrospective Studies; D012964:Sodium / Q000097:blood; D013226:Status Epilepticus / Q000097:blood / Q000453:epidemiology
D001639:Bicarbonates; D002712:Chlorides; D012964:Sodium