[Quantitative risk assessment: extrapolation methods from high doses to low doses].
Two methods of linear extrapolation from high to low doses were discussed. The first method depended on fitting a particular model (multistage, logistic) from the experimental data and then on extrapolating from the point on the dose-response curve to the lowest positive dose level employed. The linearized multistage model of carcinogenesis was used in the second method--the results obtained were highly conservative.
Szymczak
W
W
Zalładu Epidemiologii, Instytutu Medycyny Pracy, Lodzi.
Barański
B
B
D000818:Animals; D004305:Dose-Response Relationship, Drug; D016014:Linear Models; D016015:Logistic Models; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D012307:Risk Factors
D000072317:Polychlorinated Dibenzodioxins
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