Inhibitory effects of propionyl-L-carnitine on plasma extravasation induced by irritants in rodents.
The effects of propionyl-L-carnitine (PLC) in various models of inflammation were studied in rats and mice. PLC (50-200 mg/kg i.p.) dose-dependently inhibited the granuloma pouch induced by croton oil in rats, but failed to inhibit either cotton pellet granuloma or carrageenin-induced paw oedema and peritonitis. PLC (100 mg/kg i.p.) significantly reduced mouse ear oedema induced by croton oil, tetradecanoylphorbol acetate and arachidonic acid; in these models, PLC concomitantly reduced plasma extravasation, as evaluated by the leakage of Evans blue. In all the tested models, L-carnitine and acetyl-L-carnitine were ineffective, suggesting a specific protective role of PLC in the vascular component of the inflammatory process.
Amico-Roxas
M
M
Institute of Pharmacology, University of Catania School of Medicine, Italy.
Caruso
A
A
Cutuli
V M
VM
de Bernardis
E
E
Leonardi
G
G
D000108:Acetylcarnitine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002351:Carrageenan; D003872:Dermatitis / Q000517:prevention & control; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005122:Exudates and Transudates / Q000166:cytology / Q000187:drug effects; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D007509:Irritants / Q000633:toxicity*; D008297:Male; D051379:Mice; D010538:Peritonitis / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007509:Irritants; C003223:propionylcarnitine; D000108:Acetylcarnitine; D002351:Carrageenan; D002331:Carnitine