3 cases of anti-Scl-70 (topoisomerase I) antibody associated with central nervous system lupus without renal disorder.
We describe 3 cases of systemic lupus erythematosus (SLE) associated with anti-Scl-70 antibody. Common symptoms were central nervous system disorder, discoid rash, lymphadenopathy, and no renal disorder. Two of 3 cases showed some symptoms of scleroderma but could not be diagnosed as such. Although further followup is required to determine if scleroderma develops, these unique symptoms might be a subtype of SLE or a lupus-like syndrome characterized by symptoms and anti-Scl-70 antibody.
Mukai
M
M
Second Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Sagawa
A
A
Atsumi
T
T
Jodo
S
S
Amasaki
Y
Y
Nakabayashi
T
T
Watanabe
I
I
Fujisaku
A
A
Nakagawa
S
S
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D002493:Central Nervous System Diseases / Q000276:immunology*; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D012871:Skin Diseases / Q000150:complications
D000906:Antibodies; D004264:DNA Topoisomerases, Type I