ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22.
The development of type 1 (insulin dependent) diabetes mellitus (IDDM) requires a genetically susceptible host and exposure, early in life, to environmental trigger molecules that induce diabetic autoimmunity to insulin producing islet cells. We previously identified islet cell protein p69 as a candidate autoimmune target in IDDM. Here we describe a human genomic p69 fragment which allowed us to map the gene (ICA1) to chromosome 7p22.
Gaedigk
R
R
Hospital for Sick Children Research Institute, Department of Paediatrics, Toronto, Ontario, Canada.
Duncan
A M
AM
Miyazaki
I
I
Robinson
B H
BH
Dosch
H M
HM
D015139:Blotting, Southern; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D004247:DNA / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005091:Exons; D006801:Humans; D017403:In Situ Hybridization; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping
D011506:Proteins; D004247:DNA