title: [Bowen's disease. A report of 9 cases].
abstract: OBJECTIVE
  To revise clinical histological, therapeutic and evolutive specifications of Bowen's disease. To emphasise the importance of an early diagnosis and to promote treatment with topical 5-fluorouracil by the family doctor.
  
  
  METHODS
  Descriptive and transversal study.
  
  
  METHODS
  Outpatient and dermatology departments in a hospital in the metropolitan area of Madrid.
  
  
  METHODS
  Nine patients (5 male and 4 female), aged over 50, with slightly pigmented skin and diagnosed to have Bowen's disease.
  
  
  METHODS
  In five patients. Topical 5-fluorouracil (Efudix) was applied once a day for 20-30 days. Surgery was performed on three patients and one underwent radiotherapy.
  
  
  RESULTS
  The clinical histories of the patients were used. In each case a histological study of the papule that had confirmed diagnosis was carried out. Treatment was effective in all patients and no recidivation was observed during the one year follow up.
  
  
  CONCLUSIONS
  An early diagnosis and treatment of Bowen's disease is important for preventing its progression to invasive epidermoid carcinoma and later dissemination. The use of topical 5-fluorouracil is an efficient measure that can be prescribed by the family doctor.
authors.affiliation: Consulta de Dermatología, San Sebastián de los Reyes, Hospital La Paz, Madrid.
authors.forename: C
authors.initials: C
authors.lastname: de Miguel Sánchez
authors.forename: O
authors.initials: O
authors.lastname: Olmos Carrasco
authors.forename: A
authors.initials: A
authors.lastname: Sáez-Berlana
authors.forename: M D
authors.initials: MD
authors.lastname: Rodríguez García
authors.forename: I
authors.initials: I
authors.lastname: Gázquez Abad
authors.forename: J
authors.initials: J
authors.lastname: Borbujo Martínez
mesh_terms: D000368:Aged; D001913:Bowen's Disease / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D005472:Fluorouracil
vernacular_title: Enfermedad de Bowen. Presentación de nueve casos.