title: Mechanisms of virus uncoating.
abstract: In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.
authors.affiliation: Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
authors.forename: U F
authors.initials: UF
authors.lastname: Greber
authors.forename: I
authors.initials: I
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Helenius
mesh_terms: D000818:Animals; D002213:Capsid / Q000378:metabolism; D003600:Cytosol / Q000382:microbiology; D004705:Endocytosis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010447:Peptide Hydrolases / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000235:genetics
chemical_list: D011991:Receptors, Virus; D010447:Peptide Hydrolases