title: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome.
abstract: A patient with a three year history of POEMS syndrome-polyneuropathy, hepatosplenomegaly M-protein, skin changes, optic disc edema, peripheral oedema, pleuritis, lymphadenopathy, and osteosclerotic myeloma is described. The patient had a twenty year history of psoriasis and impotence was the first sign of the disease. The pathophysiology of this multisystem disorder is unknown, although the M-protein is essential. No improvement was found after radiation, chemotherapy and steroid treatment.
authors.affiliation: University Hospital IV kilometer, III Neurological Clinic, Sofia, Bulgaria.
authors.forename: I
authors.initials: I
authors.lastname: Milanov
authors.forename: D
authors.initials: D
authors.lastname: Georgiev
mesh_terms: D000328:Adult; D064211:Connectin; D004576:Electromyography; D006801:Humans; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D009194:Myeloma Proteins; D009460:Neurologic Examination; D016878:POEMS Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
chemical_list: D064211:Connectin; D009124:Muscle Proteins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins