title: Early recognition of neonatal abdominal wall necrotizing fasciitis.
abstract: Necrotizing fasciitis (NF) of the abdominal wall occurring in newborns is associated with a 50% mortality rate. Improved survival requires early diagnosis followed by aggressive surgical débridement. During a 10-year period, we treated 7 infants who developed NF. During the same period, 32 infants were admitted with omphalitis that did not progress to NF. The patients with omphalitis and those with NF were compared. Tachycardia, abnormal white blood cell counts, induration, and violaceous skin discoloration were seen exclusively in the NF patients. Polymicrobial infections were documented in 28% of the omphalitis patients and 86% of the NF patients. All omphalitis patients survived, whereas 5 of 7 (71%) NF patients died. Adjuvant hyperbaric oxygen therapy was used for 4 infants with NF, 2 of whom survived (50%). NF is a highly morbid disease, that can be distinguished from other infant abdominal wall infections by the skin changes, white blood cell counts, heart rate, and microbiologic results. Prompt diagnosis of NF improves survival when combined with aggressive surgical débridement.
authors.affiliation: Department of Surgery, Children's Hospital and Medical Center, Seattle, Washington 98105.
authors.forename: R S
authors.initials: RS
authors.lastname: Sawin
authors.forename: R T
authors.initials: RT
authors.lastname: Schaller
authors.forename: D
authors.initials: D
authors.lastname: Tapper
authors.forename: A
authors.initials: A
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Cahill
mesh_terms: D000009:Abdominal Muscles; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003646:Debridement; D005208:Fasciitis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D007231:Infant, Newborn; D007249:Inflammation / Q000150:complications; D009336:Necrosis; D014472:Umbilicus
chemical_list: D000900:Anti-Bacterial Agents