Study on initiation of human lung carcinogenesis.
Cigarette smoking condensate and diethylnitrosamine can initiate human lung carcinogenesis as they are able to induce precancerous lesions of bronchioles and the transforming ability of human fetal lung (HFL) DNA. The induction of precancerous lesions in HFL and the acquirement of the transforming ability of HFL DNA by short-term exposure to carcinogens can be combined to yield an ideal model for the initiation of human lung carcinogenesis.
Li
Z
Z
Cancer Institute, CAMS, Beijing, P.R. China.
Qi
Z
Z
Wei
H
H
Luo
X
X
Feng
Y
Y
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000235:genetics; D004052:Diethylnitrosamine; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*; D008770:Methylnitrosourea; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011230:Precancerous Conditions / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*; D051381:Rats; D014162:Transfection
D004273:DNA, Neoplasm; D004052:Diethylnitrosamine; D008770:Methylnitrosourea