Limited-sampling models for anticancer agents.
Pharmacokinetic parameters of antineoplastic drugs are usually generated from concentration/time profiles obtained after multiple venipunctures. With limited-sampling models (LSM) this number can be reduced to between one and three timed plasma samples. LSMs may facilitate population pharmacokinetic/pharmacodynamic studies, which eventually may lead to a dosing strategy based on the characteristics of the individual patient. In this article, the development, validation and application of several LSMs reported in the literature are reviewed.
van Warmerdam
L J
LJ
Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.
ten Bokkel Huinink
W W
WW
Maes
R A
RA
Beijnen
J H
JH
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D008954:Models, Biological; D012494:Sampling Studies; D013223:Statistics as Topic
D000970:Antineoplastic Agents