title: [Hyperintensive intramedullary lesions in psychiatric patients. Spatial distribution and psychopathologic symptoms].
abstract: In a sample of 130 patients who had undergone MRI (transverse T2-weighted SE sequence) patchy white matter lesions (WML) were documented according to number and spatial distribution in the brain. Ventricle-to-Brain Ratio (VBR) was determined. Configural frequency analysis led to delineation of four patient groups on the basis of WML location: 1. no WML (n = 35), 2. right frontal-temporal WML (n = 23), 3. bifrontal WML (n = 12), 4. WML in all/all but one brain region (n = 16). Psychopathological symptoms reported in the course of a maximum of 3 years were documented by chart review. In the 'pervasive WML' group psychopathological items characteristic of organic brain syndromes prevailed, mean VBR exceeded values in all other groups (ANOVA, p < 0.001). WML spatial distribution accounted for 10.2% of total psychopathological variance. Patient age, but not VBR, had a significant impact on symptom profile (MANCO-VA). When the 'pervasive WML' group was excluded, the finding of a significant effect of WML location on psychopathological symptom profiles was robust. Bifrontal WML were associated with thought incoherence, right frontal-temporal WML with affective symptoms. Findings support an impact of spatial distribution of unspecific WML on psychopathological symptoms in psychiatric patients.
authors.affiliation: Psychiatrische Klinik und Poliklinik, Universität Würzburg.
authors.forename: T
authors.initials: T
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Schmidtke
authors.forename: G
authors.initials: G
authors.lastname: Stöber
authors.forename: E
authors.initials: E
authors.lastname: Franzek
authors.forename: E
authors.initials: E
authors.lastname: Teichmann
authors.forename: E
authors.initials: E
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000523:psychology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000523:psychology; D009483:Neuropsychological Tests
vernacular_title: Hyperintense Marklagerläsionen bei psychiatrischen Patienten. Räumliche Verteilung und psychopathologische Symptome.