Individual values of excretion of benzo[a]pyrene metabolites and susceptibility to its carcinogenic effect in rats.
In white outbred LIO rats exposed to multiple intraperitoneal (i.p.) doses (10 mg/kg) of benzo[a]pyrene (BP) in the form of a water-lipid emulsion, individual peculiarities of the excretion of its metabolites, BP-7,8-diol and 3-hydroxy-BP (3-OH-BP) in urine and feces were detected and compared with the carcinogenic effect. Parameters of BP metabolite excretion differed from those found in our previous experiments with rats exposed to single high i.p. doses of BP (100 and 200 mg/kg), dissolved in sunflower oil [11,12]. In comparison with our previous observation, in the present study, the carcinogenic effect was considerably weaker (5/22 versus 10/19). The rats that developed tumours of internal tissues (four peritoneal malignant histiocytomas and one lung lymphosarcoma), excreted higher quantities of BP-7,8-diol in the urine than other rats. The possible implication of monitoring excretion of BP metabolites for predicting individual susceptibility to its carcinogenic effect is discussed.
Tyndyk
M L
ML
N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation.
Zabezhinski
M A
MA
Bykov
V J
VJ
Dikun
P P
PP
Dymochka
L A
LA
Nepomnyaschaya
O B
OB
Yatsuk
O S
OS
Yermilov
V B
VB
Likhachev
A J
AJ
D000818:Animals; D001564:Benzo(a)pyrene / Q000031:analogs & derivatives / Q000378:metabolism*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000652:urine; D051381:Rats; D013997:Time Factors
D001564:Benzo(a)pyrene