title: Guillain-Barré syndrome associated with IgM anti-GM1 antibody following Campylobacter jejuni enteritis.
abstract: We report a 4-year-old girl diagnosed as having Guillain-Barré syndrome after infection by Penner serotype 19 of Campylobacter jejuni. The patient had the HLA-B35 antigen. Neurological examination revealed distal-dominant weakness and intact sensation. Serial electrophysiological studies indicated that the predominant process was axonal degeneration involving motor nerves. An enzyme-linked immunosorbent assay revealed the presence of high titres of serum IgM antibodies to gangliosides GM1 and GM2. The IgM auto-antibody titres decreased concurrently with the clinical course of the illness and no switching from IgM to IgG secretion took place.
authors.affiliation: Department of Paediatrics, School of Medicine, University of Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: J
authors.initials: J
authors.lastname: Takanashi
authors.forename: H
authors.initials: H
authors.lastname: Niimi
authors.forename: N
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000888:Antibodies, Anti-Idiotypic; D002169:Campylobacter Infections / Q000150:complications* / Q000503:physiopathology; D016123:Campylobacter jejuni; D002675:Child, Preschool; D004594:Electrophysiology; D004751:Enteritis / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology* / Q000503:physiopathology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007075:Immunoglobulin M; D005677:G(M1) Ganglioside