[The stacking interaction of antibiotics of the pyrimido[5,4-e]-1,2,4-triazine series with purines].
The changes in the PMR spectra of purine bases added to aqueous solutions (D2O) of antibiotics of the pyrimido[5,4-e]-1,2,4-triazine type, reumycin and xanthotricin as well as the changes in the PMR indicate formation of heteroassociates with batch structure as a result of stacking interaction. Chemotherapeutic effect of the antibiotics is explained by their intercalation into the batches of the nucleic acids bases, which violates their functioning.
Antonovskiĭ
V L
VL
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D011685:Purine Nucleotides / Q000737:chemistry*; D011744:Pyrimidinones / Q000737:chemistry*; D012996:Solutions; D014227:Triazines / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D011685:Purine Nucleotides; D011744:Pyrimidinones; D012996:Solutions; D014227:Triazines; C009169:reumycin; C009570:toxoflavin
Steking-vzaimodeĭstvie antibiotikov pirimido[5,4-e]-1,2,4-triazinovogo riada s purinami.