Structure, function and regulation of cytoplasmic dynein.
Molecular cloning studies have provided valuable structural information about the different subunits of cytoplasmic dynein and their relationships to their axonemal dynein counterparts. Recent unexpected findings regarding the role of this enzyme in mitosis have emerged from mutational analyses and microinjection experiments, while studies of organelle transport in vivo have revealed clues to mechanisms for physiological regulation of dynein activity.
Schroer
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TA
Department of Biology, Johns Hopkins University, Baltimore, MD 21218.
D000818:Animals; D003593:Cytoplasm / Q000502:physiology*; D004398:Dyneins / Q000737:chemistry / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D046911:Macromolecular Substances; D008870:Microtubules / Q000502:physiology*; D015388:Organelles / Q000502:physiology*
D046911:Macromolecular Substances; D004398:Dyneins