[Level of total cholesterol in serum of patients with breast cancer treated with tamoxifen].
Estrogens play an important role in lipid metabolism regulation. The present study aimed at evaluating an effect of anti-estrogen therapy with tamoxifen on blood serum total cholesterol levels in women with breast cancer. Mean total cholesterol concentration in women treated with tamoxifen was 5.36 mmol/l vs. 6.64 mmol/l in patients not treated with tamoxifen. The difference was statistically significant (P < .001). Hypercholesterolemia was diagnosed only in 1 patient treated with tamoxifen (2.4%) while in 9 (27.35) patients not given this drug. The difference was also statistically significant (P < .001). Lower blood serum concentrations of the total cholesterol in women treated with tamoxifen are probably produced by the estrogen-like effect on lipid metabolism.
Wojtacki
J
J
Wojewódzkiej Przychodni Onkologicznej, Gdańsku.
Dziewulska-Bokiniec
A
A
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013629:Tamoxifen / Q000627:therapeutic use*
D013629:Tamoxifen; D002784:Cholesterol
Stezenie cholesterolu całkowitego w surowicy u chorych na raka sutka leczonych tamoksyfenem.