title: Comparative efficacy of diclofenac and flurbiprofen for maintenance of pupillary dilatation during cataract surgery.
abstract: A double-blind, prospective, randomized clinical study was undertaken to evaluate the relative efficacy of flurbiprofen 0.03% and diclofenac 0.1% eye drops, in combination with routinely used mydriatics, in maintaining pupillary dilatation during extracapsular cataract surgery with intraocular lens implantation. The effectiveness of administering systemic flurbiprofen along with the topical drugs in enhancing maintenance of pupillary dilatation also was assessed. Pupillary diameter, as measured at various surgical stages, was significantly greater in the patients receiving diclofenac or flurbiprofen eye drops as compared with those in a control group who did not (P < .001). While the maintenance of pupillary dilatation was consistently better with diclofenac than with flurbiprofen, the difference was not statistically significant. Furthermore, though maintenance of pupillary dilatation was better in cases in which systemic flurbiprofen was added to the preoperative drug regime, again, the difference was not significant.
authors.affiliation: Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
authors.forename: M S
authors.initials: MS
authors.lastname: Sachdev
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: D
authors.initials: D
authors.lastname: Talwar
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: V K
authors.initials: VK
authors.lastname: Dada
mesh_terms: D000287:Administration, Topical; D002387:Cataract Extraction; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D007498:Iris / Q000187:drug effects; D007910:Lenses, Intraocular; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects*
chemical_list: D009883:Ophthalmic Solutions; D004008:Diclofenac; D005480:Flurbiprofen