title: The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis.
abstract: Cytochrome c oxidase L-form transcript-binding protein (COLBP) activity parallels the tissue-specific mRNA expression of bovine cytochrome c oxidase liver isopeptides. A similar RNA-binding activity is found in human myoblast and liver Hep G2 cell homogenates. Human COLBP activity, however, is not present in myotubes or adult skeletal muscle. It is proposed that COLBP down-regulation during muscle cell differentiation may underlie oxidase isoform switching during myogenesis.
authors.affiliation: Division of Clinical Neuroscience, University of Newcastle upon Tyne, Medical School, UK.
authors.forename: T
authors.initials: T
authors.lastname: Preiss
authors.forename: Z M
authors.initials: ZM
authors.lastname: Chrzanowska-Lightowlers
authors.forename: R N
authors.initials: RN
authors.lastname: Lightowlers
mesh_terms: D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D015536:Down-Regulation; D003576:Electron Transport Complex IV / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic; D005969:Glutamate Dehydrogenase / Q000096:biosynthesis*; D006801:Humans; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D016601:RNA-Binding Proteins / Q000096:biosynthesis*
chemical_list: D016601:RNA-Binding Proteins; D005969:Glutamate Dehydrogenase; D003576:Electron Transport Complex IV