Familial risk of breast cancer and abortion.
We found that the risk of breast cancer associated with a family history of breast cancer increased with the number of abortions (induced as well as spontaneous) in a study of 495 breast cancer cases and 785 controls aged 20 to 56 years. For the women who had undergone at least two abortions, the risk associated with a family history did not seem to depend on the type of abortion. This finding suggests that the effect of a family history on the risk of breast cancer is modified by event(s) resulting from abortions. Further epidemiological studies should be conducted to verify the existence of this interaction.
Andrieu
N
N
Unité de Recherche en Epidémiologie des Cancers, Institut Gustave-Roussy, Villejuif, France.
Clavel
F
F
Gairard
B
B
Piana
L
L
Brémond
A
A
Lansac
J
J
Flamant
R
R
Renaud
R
R
D000028:Abortion, Induced / Q000009:adverse effects*; D000022:Abortion, Spontaneous / Q000150:complications*; D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D012306:Risk