Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved fish technique.
The gene for epidermal growth factor receptor (EGFR) has been localized to the p14-p12 region of human chromosome 7 by somatic cell hybridization and radioisotope in situ hybridization techniques. In this paper, we report the precise mapping of the EGFR gene to the band p12 of chromosome 7 using a novel method in which fluorescence images from in situ hybridization and Q-banding are computer graphically merged. The novel procedure is described in detail.
Wang
Y
Y
Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
Minoshima
S
S
Shimizu
N
N
D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*
D066246:ErbB Receptors