[Current topics in nuclear receptor study].
Nuclear receptors for steroid/thyroid hormones and fat-soluble vitamins A and D act as ligand-inducible transcriptional factors. Recent progress in nuclear receptor study showed that nuclear receptors transmit the signals of those ligand into gene expression. In this article, some topics in this field were illustrated with special attention to cancer and retinoid actions. Functional analysis of target enhancer elements of distinct classes of nuclear receptors revealed the target specificity and unselectivity. Some of molecular mechanism for oncogenesis and retinoid actions have been clarified at nuclear receptor levels.
Kato
S
S
Department of Agricultural Chemistry, Tokyo University of Agriculture.
D000818:Animals; D002869:Chromosome Aberrations; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000502:physiology*; D018168:Receptors, Retinoic Acid / Q000502:physiology*
D011965:Receptors, Glucocorticoid; D018168:Receptors, Retinoic Acid