title: Malignant pleural effusion from prostatic adenocarcinoma resolved with hormonal therapy.
abstract: A 73-year-old man presented with dyspnea, right-sided pleural effusion, and bilateral pulmonary infiltrates. The pleural fluid revealed adenocarcinoma cells that stained positively for prostatic specific antigen (PSA), which confirmed this uncommon metastatic involvement from prostate cancer. The dyspnea, effusion, and infiltrates disappeared after therapy with flutamide and leuprolide was started. This report demonstrates both the usefulness of immunocytochemical staining for PSA in ascertaining the origin of malignant pleural effusion in men and the effectiveness of the aforementioned endocrine therapy in such setting.
authors.affiliation: Servicio de Medicina Interna, Hospital de Laredo, Cantabria, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Carrascosa
authors.forename: J L
authors.initials: JL
authors.lastname: Perez-Castrillon
authors.forename: M A
authors.initials: MA
authors.lastname: Mendez
authors.forename: L
authors.initials: L
authors.lastname: Cillero
authors.forename: R
authors.initials: R
authors.lastname: Valle
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy / Q000556:secondary*; D000368:Aged; D005485:Flutamide / Q000008:administration & dosage*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D008297:Male; D016066:Pleural Effusion, Malignant / Q000209:etiology*; D010997:Pleural Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D005485:Flutamide; D016729:Leuprolide