Engineered human vaccines.
The limitations of human vaccines in use at present and the design requirements for a new generation of human vaccines are discussed. The progress in engineering of human vaccines for bacteria, viruses, parasites, and cancer is reviewed, and the data from human studies with the engineered vaccines are discussed, especially for cancer and AIDS vaccines. The final section of the review deals with the possible future developments in the field of engineered human vaccines and the requirement for effective new human adjuvants.
Sandhu
J S
JS
Division of Immunology and Neurobiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.
D016915:AIDS Vaccines / Q000276:immunology; D000595:Amino Acid Sequence; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D006373:Helminthiasis / Q000517:prevention & control; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
D016915:AIDS Vaccines; D001428:Bacterial Vaccines; D017780:Malaria Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines