Axon overproduction and elimination in the anterior commissure of the developing rhesus monkey.
We have analyzed axon overproduction and elimination in the anterior commissure (AC) of 16 fetal, neonatal, and juvenile rhesus monkeys. Axons are added to the AC at an average rate of 115,000/day during the last two-thirds of gestation, and growth cones are present in a constant proportion to AC axons throughout this period. The peak number of approximately 11 million axons in the AC is reached at birth. Thereafter, axons are eliminated at a net rate of approximately 1 axon/sec during the first 3 postnatal months until the adult number of approximately 3.3 +/- 0.5 million axons is reached. Although there is considerable variability in AC axon number during the period of axon loss, the adult number of AC axons is relatively invariant among the eight adult rhesus monkeys examined. Increase in axon diameter and myelination begins before the major phase of axon elimination and is completed long after the adult number of axons is reached. Apparently, myelinated axons are not eliminated from the AC. Quantitative differences in the magnitude and timing of axon overproduction and elimination in the AC versus that in the corpus callosum (LaMantia and Rakic [1990] J. Neurosci. 10:2156) indicate specific modulation of the development of each commissure, perhaps reflecting differences in the developmental history and functional identity of the distinct cortical regions that give rise to them. This process of overproduction and elimination of AC axons during postnatal development in primates might contribute to individual variations in AC size correlated with a wide range of physical and behavioral differences.
LaMantia
A S
AS
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Rakic
P
P
D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D001921:Brain / Q000166:cytology* / Q000254:growth & development / Q000648:ultrastructure; D003337:Corpus Callosum / Q000166:cytology / Q000254:growth & development; D005260:Female; D008253:Macaca mulatta / Q000502:physiology*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000254:growth & development; D009457:Neuroglia / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000648:ultrastructure; D011247:Pregnancy