title: Regulatory squelching.
abstract: An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.
authors.affiliation: Medizinische Hochschule Hannover, Institut für Molekularbiologie, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Cahill
authors.forename: W H
authors.initials: WH
authors.lastname: Ernst
authors.forename: R
authors.initials: R
authors.lastname: Janknecht
authors.forename: A
authors.initials: A
authors.lastname: Nordheim
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D005786:Gene Expression Regulation; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors; D004247:DNA