Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes.
Endocytosis of antigen by antigen-presenting cells results in the production of peptides that bind to newly synthesized class II molecules of the major histocompatibility complex. A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. These vesicles also transiently accumulate newly synthesized class II and class II-peptide complexes and appear to be a compartment specialized for the transport and loading of class II molecules.
Amigorena
S
S
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8002.
Drake
J R
JR
Webster
P
P
Mellman
I
I
D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte; D001402:B-Lymphocytes / Q000378:metabolism*; D001692:Biological Transport; D001704:Biopolymers; D002451:Cell Compartmentation; D002458:Cell Fractionation; D004705:Endocytosis; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D007158:Immunologic Techniques; D051379:Mice; D010455:Peptides / Q000378:metabolism; D017455:Receptors, IgE / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000944:Antigens, Differentiation, B-Lymphocyte; D001704:Biopolymers; D000949:Histocompatibility Antigens Class II; D010455:Peptides; D017455:Receptors, IgE; C045084:invariant chain