Retrograde interactions during formation and elimination of neuromuscular synapses.
Maturation of neuromuscular synapses depends on dynamic interactions between presynaptic motor neurons and postsynaptic muscle cells. Recent studies have addressed the cellular mechanisms underlying these interactions in cell cultures and in developing animals. Retrograde signals from the postsynaptic muscle cells appear to play critical roles in all stages of synapse development, from the initial synaptogenesis to the stabilization or elimination of the synapse.
Dan
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Fairchild Center, Department of Biological Sciences, Columbia University, New York, New York 10027.
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D000818:Animals; D009469:Neuromuscular Junction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*