title: On the structure of mitochondrial porins and its homologies with bacterial porins.
abstract: By use of computer modelling, we have predicted a model of 16 transmembrane beta-strands for mitochondrial porins structure from human, Saccharomyces cerevisiae, Neurospora crassa and Dictyostelium discoideum. The proposed model takes into account biochemical and immunological data reported in the literature, as well as electrophysiological results obtained with yeast mitochondrial porins with mutations at selected amino acids. The predicted structure is very similar to that of some bacterial porins, as apparent from the homology of their hydropathic profiles.
authors.affiliation: Istituto di Cibernetica e Biofisica, Consiglio Nazionale delle Ricerche, Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rauch
authors.forename: O
authors.initials: O
authors.lastname: Moran
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003198:Computer Simulation; D004023:Dictyostelium / Q000737:chemistry / Q000235:genetics; D004926:Escherichia coli / Q000737:chemistry / Q000235:genetics; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009492:Neurospora crassa / Q000737:chemistry / Q000235:genetics; D018272:Porins / Q000737:chemistry* / Q000235:genetics*; D017433:Protein Structure, Secondary; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics; D016992:Rhodobacter / Q000737:chemistry / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics; D050994:Voltage-Dependent Anion Channels
chemical_list: D005656:Fungal Proteins; D008565:Membrane Proteins; D018272:Porins; D015800:Protozoan Proteins; D050994:Voltage-Dependent Anion Channels