Werner's syndrome associated with spastic paraparesis and peripheral neuropathy.
A Werner's syndrome patient with spastic paraparesis and polyneuropathy had slowing of central and peripheral nerve conduction. Sural nerve biopsy revealed a significantly higher frequency of demyelination and remyelination and a loss of myelinated fibers. These data suggest that the central and peripheral nervous systems are affected in Werner's syndrome.
Umehara
F
F
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Abe
M
M
Nakagawa
M
M
Izumo
S
S
Arimura
K
K
Matsumuro
K
K
Osame
M
M
D000328:Adult; D003711:Demyelinating Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D013497:Sural Nerve / Q000473:pathology; D014898:Werner Syndrome / Q000175:diagnosis*