[Adjuvant chemotherapy in ovarian carcinoma. Preliminary results].
The study is prospective and includes 72 patients. All the patients are subjected to surgical treatment--total hysterectomy with bilateral adnexectomy and partial or total omentectomy and all of them are without macroscopic metastases in the abdominal cavity. Adjuvant chemotherapy includes from 3 to 5 courses of combination chemotherapy with platinum preparation (Bio-cisplatinum) in intervals of 30 days. Seven out of 72 studied patients (9.7%) have shown recurrence of the neoplastic disease. These patients are in stage II and III. Four of them are at age below 50 years, while the other 3--over 50. With the greatest relative part are the recurrent patients with granulosa cell cancer--33%, followed by the patients with mixed histologic type--25%, with mesonephric cancer--17% and papillary cystadenocarcinoma--10%. Regardless the small number of patients in the different groups, a tendency is outlined for a better therapeutic results after application of adjuvant chemotherapy in sensitive to cytostatic treatment histologic types of ovarian cancer. The disease free interval and the survival prolong, especially in II and III stage patients. Better therapeutic results are achieved by application of 5 courses of platinum including chemotherapy than by the application of 3 courses.
Velikova
M
M
Tsvekova
V
V
Koĭnov
K
K
D000290:Adnexa Uteri / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002031:Bulgaria / Q000453:epidemiology; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011446:Prospective Studies; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003606:Dacarbazine; D003520:Cyclophosphamide; D002945:Cisplatin; D005472:Fluorouracil
Adiuvantna khimioterapiia na ovarialniia kartsinom. Predvaritelni rezultati.