Localization of the Tamm-Horsfall glycoprotein (uromodulin) gene to chromosome 16p12.3-16p13.11.
Mapping studies using a panel of 22 rodent-human somatic cell hybrids have helped to localize the Tamm-Horsfall glycoprotein (uromodulin) gene (UMOD), which has previously been reported to map to 16p13.11, to the region 16p12.3-qter. The combined results indicate that UMOD is located distal to D16S295 and proximal to D16S287 and in the region 16p12.3-16p13.11. Uromodulin is known to affect the formation of calcium-containing kidney stones, and this localization of UMOD will help in studies of families with autosomal forms of nephrolithiasis.
Pook
M A
MA
MRC Molecular Medicine Group, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Jeremiah
S
S
Scheinman
S J
SJ
Povey
S
S
Thakker
R V
RV
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D006822:Hybrid Cells; D007669:Kidney Calculi / Q000235:genetics; D008969:Molecular Sequence Data; D009088:Mucoproteins / Q000235:genetics*; D053495:Osteopontin; D011506:Proteins / Q000235:genetics; D012377:Rodentia; D058949:Uromodulin
D009088:Mucoproteins; D011506:Proteins; C548612:UMOD protein, human; D058949:Uromodulin; D053495:Osteopontin