title: Aggravation of experimental allergic conjunctivitis by environmental chemical and physical factors.
abstract: The effects of trichlorfon (DEP, Dipterex, anticholinesterase pesticide) and paraquat dichloride (Gramoxon, inhibitor of superoxide dismutase) on passive anaphylactic reaction in guinea pig conjunctiva using Japanese cedar pollen were quantitatively studied. For estimation of allergic conjunctivitis, Evans blue after i.v. injection was extracted from conjunctiva and measured spectrophotometrically. Allergic conjunctivitis was apparently aggravated by extremely low dosages of organophosphorus pesticide (10(-5) mg/kg) and organochlorine herbicide (10(-4) mg/kg). The aggravation of allergic conjunctivitis was also observed after exposure to cathode ray tubes used in commercial television, possibly due to electromagnetic waves. IgE-mediated allergic reaction could be non-specifically potentiated by such environmental factors.
authors.affiliation: Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: T
authors.initials: T
authors.lastname: Namba
authors.forename: K
authors.initials: K
authors.lastname: Horiuchi
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: S
authors.initials: S
authors.lastname: Ishikawa
mesh_terms: D000485:Allergens; D000818:Animals; D001610:Beta Particles / Q000009:adverse effects*; D003233:Conjunctivitis, Allergic / Q000209:etiology*; D004781:Environmental Exposure / Q000009:adverse effects*; D006168:Guinea Pigs; D010269:Paraquat / Q000009:adverse effects; D010575:Pesticides / Q000009:adverse effects*; D011058:Pollen; D014236:Trichlorfon / Q000009:adverse effects
chemical_list: D000485:Allergens; D010575:Pesticides; D014236:Trichlorfon; D010269:Paraquat