[Measurement of serum tissue-polypeptide antigen (TPA) levels by EIA employing monoclonal antibody].
Serum TPA levels were measured by high-sensitive EIA employing anti-TPA monoclonal antibody M3 in 188 patients with solid tumors. The positive rate of serum TPA levels in 131 primary surgical patients was 39.7%, whereas that in 57 recurrent patients was 87.7%, and 20 recurrent patients (35.1%) showed higher TPA levels than 500 U/l. In patients with gastric and colorectal carcinomas, TPA levels increased in accordance with progression of the staging. The positive rate of TPA levels in patients with benign disease was 8.3% (4/48). Therefore, this EIA were thought to be clinically useful as a tumor marker for solid tumors.
Takami
H
H
First Dept. of Surgery, Teikyo University School of Medicine.
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000097:blood; D010455:Peptides / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood; D019396:Tissue Polypeptide Antigen
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen