Collectin receptor (C1q receptor): structure and function.
Isolated collectin receptor (C1q receptor) is a single polypeptide chain of approximately 60 kDa (Malhotra and Sim, 1989). Sequence analysis shows that it belongs to a family of proteins which include calreticulin, a component of RoSSA autoantigen, Onchocerca volvulus antigen (RAL-1) and B50 murine melanoma antigen (Malhotra et. al., 1993). The receptor is widely distributed on leukocytes, platelets and endothelium and acts as a receptor for a group of structurally-related complement or lectin opsonins (the collectins), which include C1q, mannose binding protein (MBP), lung surfactant protein A (SP-A) and conglutinin (Malhotra et al., 1990).
Malhotra
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MRC Immunochemistry Unit, Department of Biochemistry, Oxford, UK.
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D002352:Carrier Proteins; D015922:Complement C1q / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors; D008264:Macrophages / Q000502:physiology; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D009000:Monocytes / Q000502:physiology; D017433:Protein Structure, Secondary; D011951:Receptors, Complement / Q000737:chemistry* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
C087299:C1QBP protein, human; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011951:Receptors, Complement; C032402:complement 1q receptor; D015922:Complement C1q