[GABA-opioid interaction during the recovery of a passive avoidance conditioned reaction].
The modulating influence of preliminary activation of the delta-opiate receptors on retrieval and retention of the memory trace during the blockade of various components of GABA-benzodiazepine-ionophore complex in a passive avoidance paradigm was studied in mice. The psychogenic amnesia was caused by a detention of a mouse in the dangerous compartment. Bicuculline (1 mg/kg), picrotoxin (1 mg/kg) and flumazenil (10 mg/kg) injected prior to testing attenuated the retrieval deficit caused by amnesia. Pretraining administration of leu-enkephalin (0.2 mg/kg) facilitated the efficiency of the action of the blockade of benzodiazepine receptors on the retrieval of the passive avoidance response whereas the blockade of GABA-A receptors and chloride channels was non-effective. These experiments provide additional support for the hypothesis that "neurochemical set" plays an important role of a regulator determining the neurochemical interaction between opiate receptor and GABA-benzodiazepine-ionophore complex in modulating memory processes.
Dubrovina
N I
NI
Il'iuchënok
R Iu
RIu
D000647:Amnesia / Q000503:physiopathology; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004743:Enkephalin, Leucine / Q000494:pharmacology; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010852:Picrotoxin / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology*; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D001640:Bicuculline; D004743:Enkephalin, Leucine; D005442:Flumazenil; D010852:Picrotoxin; D018079:Receptors, GABA; D017465:Receptors, Opioid, delta
GAMK-opioidnoe vzaimodeĭstvie pri vosstanovlenii uslovnoĭ reaktsii passivnogo izbeganiia.