[Septicemic cutaneous localization of cryptococcosis following renal transplantation in a female].
Cryptococcosis is a systemic disease caused by the yeast-like fungus Cryptococcus neoformans. Cutaneous manifestations, although rare, may precede other organ involvements. A case of cutaneous cryptococcosis is described herein. The skin lesions in our patient (a 47-year old female with renal transplant) consisted of acute cellulitis over her left and right thighs, revealing a septicemic infection. The patient received immunosuppressive drugs (prednisone, azathioprine). Clinical, mycological and histopathological data are described in details. Amphotericin B and fluconazole were initially successful, but a relapse with Cryptococcus meningitis required the adjunction of itraconazole to treatment. This case report underlines the insufficient effectiveness of fluconazole and the success of itraconazole.
Dupond
A S
AS
Service de Dermatologie, CHU Saint-Jacques.
Humbert
P
P
Faivre
B
B
Hory
B
B
Barale
T
T
Laurent
R
R
Agache
P
P
D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000150:complications* / Q000188:drug therapy; D003881:Dermatomycoses / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D016919:Meningitis, Cryptococcal / Q000150:complications; D008875:Middle Aged; D013848:Thigh; D016896:Treatment Outcome
D000935:Antifungal Agents
Localisations cutanées septicémiques d'une cryptococcose chez une greffée rénale.