Rapid identification of ergot derivatives by 1H-NMR spectroscopy.
The 400 MHz 1H-NMR spectra of some therapeutically important ergot derivatives (three bases, four protonated bases and four dihydroergoline salts) are analysed in terms of the low field chemical shift region (above 5 ppm), common resonances of rings C and D (below 5 ppm) and C-8 substituent features. Attention is drawn to data of specific analytical value, and a scheme for the rapid identification of members of this group of ergots proposed. Features which provide evidence of the solute conformation of ring D, and isomerization to less active C-8 epimers are also emphasized.
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School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
D001971:Bromocriptine / Q000032:analysis; D004873:Ergolines / Q000032:analysis* / Q000737:chemistry; D004878:Ergotamine / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D012015:Reference Standards; D013237:Stereoisomerism
D004873:Ergolines; D001971:Bromocriptine; C100270:ergocristine; C100269:ergocryptine; C100271:ergocornine; D004878:Ergotamine