Chloroquine induced mania.
OBJECTIVE
To find out whether chloroquine by itself can induce a manic syndrome and to study the course of illness in such cases.


METHODS
All cases of manic episodes occurring in clear consciousness were scrutinized and those occurring after the use of chloroquine were included in the study. One case seen by one of the authors in the community was included. The cases were followed for variable periods.


RESULTS
Six cases of chloroquine induced mania were identified of which two subtypes could be delineated with heterogeneous course, variable severity and difference in susceptibility of recurrence with rechallenge.


CONCLUSIONS
It is concluded that chloroquine can cause secondary mania and it should be used cautiously in the predisposed.
Akhtar
S
S
Central Institute of Psychiatry, Ranchi, India.
Mukherjee
S
S
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004565:Electroconvulsive Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy; D011619:Psychotropic Drugs / Q000008:administration & dosage
D011619:Psychotropic Drugs; D002738:Chloroquine