title: Effects of quinine on the mechanical frequency response of the cupula in the fish lateral line.
abstract: Quinine induces changes in the motion of the cupula in the lateral line canal of the African knife-fish in response to sinusoidal water movements. Two different phases in the action of quinine on the cupular frequency response can be discerned. In the first phase the best frequency, i.e., the frequency at which the cupular vibratory displacement is maximal in response to constant-amplitude sinusoidal canal fluid displacement, shifts toward higher frequencies. During this phase, lasting about 70-100 min, the best frequency increases by a factor between 1.3 and 1.5. In the second phase, during roughly the following 90 min, the best frequency decreases gradually to a value 0.3-0.5 times that observed before the application of quinine.
authors.affiliation: Department of Biophysics, University of Groningen, The Netherlands.
authors.forename: S M
authors.initials: SM
authors.lastname: van Netten
authors.forename: K K
authors.initials: KK
authors.lastname: Karlsson
authors.forename: S M
authors.initials: SM
authors.lastname: Khanna
authors.forename: A
authors.initials: A
authors.lastname: Flock
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D005399:Fishes; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D011803:Quinine / Q000494:pharmacology*; D012679:Sense Organs / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D011803:Quinine