[Synthesis of cyclic oligodeoxyribonucleotides with non-nucleotide inserts].
An effective method for the oligonucleotide cyclization using BrCN-induced chemical ligation was developed. The novel idea to incorporate non-nucleotide inserts makes the process of cyclizations independent of the inner secondary structure of the linear precursor. An set of assays were developed to confirm the cyclic structure of the compounds obtained.
Oretskaia
T S
TS
Dolinnaia
N G
NG
Merenkova
I N
IN
Krynetskaia
N F
NF
Romanova
E A
EA
Volkov
E M
EM
Blumenfeld
M
M
Vasseur
M
M
Shabarova
Z A
ZA
D001483:Base Sequence; D003488:Cyanogen Bromide; D004591:Electrophoresis, Polyacrylamide Gel; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D009838:Oligodeoxyribonucleotides; D003488:Cyanogen Bromide
Sintez tsiklicheskikh oligodezoksiribonukleotidov s nenukleotidnymi vstavkami.