title: Concomitant boron-neutron capture therapy during fast-neutron irradiation of a rat glioma.
abstract: OBJECTIVE
  Fast-neutron irradiation and boron-neutron capture therapy (BNCT) have been independently investigated as treatments for malignant disease. This study tested the feasibility of enhancing fast-neutron irradiation with concomitant BNCT.
  
  
  METHODS
  Seventeen male Fisher rats, each weighing 180-200 g and bearing 36B10 gliomas, were irradiated with graded doses of fast-neutron radiation. Half of the animals received an L-para-boronophenylalanine (BPA) fructose complex prior to treatment. An in vitro colony-forming assay was used to measure surviving fraction.
  
  
  RESULTS
  A significantly lower surviving fraction was noted in the tumors from the BPA group compared with those receiving neutrons alone at the three lower neutron doses (P < .005). With use of a linear quadratic curve fit of cell survival, the dose modifying factor was 1.32 at the 0.10 surviving fraction. Mean tumor boron concentration was 68.4 micrograms/g.
  
  
  CONCLUSIONS
  BNCT enhancement of fast-neutron irradiation is feasible in an in vivo tumor system.
authors.affiliation: Department of Radiation Oncology, University of Washington, Seattle.
authors.forename: T A
authors.initials: TA
authors.lastname: Buchholz
authors.forename: J S
authors.initials: JS
authors.lastname: Rasey
authors.forename: G E
authors.initials: GE
authors.lastname: Laramore
authors.forename: J C
authors.initials: JC
authors.lastname: Livesey
authors.forename: L
authors.initials: L
authors.lastname: Chin
authors.forename: R
authors.initials: R
authors.lastname: Risler
authors.forename: D K
authors.initials: DK
authors.lastname: Hamlin
authors.forename: A M
authors.initials: AM
authors.lastname: Spence
authors.forename: T W
authors.initials: TW
authors.lastname: Griffin
mesh_terms: D000818:Animals; D001895:Boron / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D005214:Fast Neutrons; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014410:Tumor Stem Cell Assay
chemical_list: D001895:Boron