Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q.
A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.
Tomfohrde
J
J
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-8591.
Silverman
A
A
Barnes
R
R
Fernandez-Vina
M A
MA
Young
M
M
Lory
D
D
Morris
L
L
Wuepper
K D
KD
Stastny
P
P
Menter
A
A
D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D017931:DNA Primers; D004276:DNA, Satellite / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D015236:HLA-C Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics*; D012984:Software
D017931:DNA Primers; D004276:DNA, Satellite; D005819:Genetic Markers; D015236:HLA-C Antigens; C528994:HLA-C*06 antigen