[Inhibition of oxygen free radicals in potassium channels of cardiac myocytes and the action of salvianolic acid A].
By using the patch clamp technique, the effect of oxygen free radicals on the single potassium channels of cardiac papillary muscle cells were studied, as well as the action of salvianolic acid A. It was found that xanthane-xanthane oxidase generated oxygen free radicals could apparently inhibited the unitary currents of the single potassium channel activity. This inhibition was reversed by salvianolic acid A, which is an effective component extracted from Salvia miltiorrhiza.
Bao
G
G
Institute of Basic Medical Sciences, CAMS, Beijing.
D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology*; D002462:Cell Membrane; D005609:Free Radicals; D007773:Lactates / Q000494:pharmacology*; D009206:Myocardium / Q000166:cytology*; D010210:Papillary Muscles / Q000166:cytology; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D002109:Caffeic Acids; D005609:Free Radicals; D007773:Lactates; D015221:Potassium Channels; C066201:salvianolic acid A