title: [Pathological observations on massive fibrosis of coal-mine pneumoconiosis].
abstract: Morphological studies on massive pulmonary fibrosis due to pneumoconiosis in 42 cases were performed. The cases were divided into two types: the coalescence of fibrotic nodules type and the progressive massive fibrosis type. The former includes fusion of simple silica or coal-silica nodules and coalescence of mainly coal-silico-tubercle nodules. When pneumoconiosis is complicated by tuberculosis, the coal-silico-tubercle is the pathological change caused by the combination of dust and inflammation. The resulting conglomerate mass can be classified as progressive massive fibrosis. A comparison of micro-element content between non-massive fibrosis and massive fibrosis was made, and only the silicon content showed a significant difference (P < 0.05). The morphology, pathogenesis and formation of progressive massive fibrosis are discussed.
authors.affiliation: Department of Pathology, North China Coal (Administration) Medical College, Tangshan.
authors.forename: Q J
authors.initials: QJ
authors.lastname: Li
mesh_terms: D000874:Anthracosilicosis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003032:Coal Mining; D006801:Humans; D008168:Lung / Q000737:chemistry / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000473:pathology; D012830:Silicotuberculosis / Q000473:pathology; D014131:Trace Elements / Q000032:analysis
chemical_list: D014131:Trace Elements