[Cardiac manifestations in advanced HIV infection].
Incidence, type and clinical significance of cardiac involvement in advanced HIV infection was determined in 32 patients (30 men, two women; mean age 34.2 [21-52] years; mean CD4-cell number 52.2 [0-192]/microliters) over a period of 31 months. Any cardiac involvement was assessed diagnostically by one- and two-dimensional and Doppler echocardiography, complemented by other examinations and results of treatment. 14 patients (43.8%) had abnormal cardiac findings, presumably AIDS-associated. This included left ventricular pump dysfunction of various degrees of severity (n = 11), left ventricular dilatation (n = 2), pericardial effusion (n = 11), as well as cor pulmonale in primary pulmonary arterial hypertension (n = 2). In one patient the first manifestation of AIDS was tubercular pericarditis; in two patients there was a likely connection to disseminated pneumocystis infection and toxoplasmosis, respectively. In 11 patients no specific cause was found for the cardiac involvement. Nine of the 14 patients (64%) had symptoms due to the cardiac involvement. These findings indicate that the incidence and clinical significance of cardiac involvement must be taken into account in any treatment concept for AIDS.
Ewig
S
S
Medizinische Universitätsklinik Bonn.
Fehske
W
W
Omran
H
H
Rockstroh
J K
JK
Lüderitz
B
B
D000386:AIDS-Related Complex / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D000328:Adult; D016009:Chi-Square Distribution; D004452:Echocardiography / Q000295:instrumentation / Q000706:statistics & numerical data; D015150:Echocardiography, Doppler / Q000295:instrumentation / Q000706:statistics & numerical data; D005260:Female; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D015497:HIV-1; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged
Kardiale Manifestationen bei fortgeschrittener HIV-Infektion.