[Cellular immunity in patients with newly detected insulin-dependent diabetes mellitus].
Twenty-five diabetics with insulin-dependent condition were examined at the debut of the disease before insulin therapy, as were 10 healthy donors. Under study were relative and absolute counts of T lymphocytes, NK cells, B lymphocytes, DR-T lymphocytes, Th, Ts, and Th/Ts index. Patients' and donors' sera were tested for autoantibodies to P64-69kD antigenic complex. Characteristic features of cellular immunity of patients with newly-detected diabetes were disclosed. Counts of B lymphocytes and Dr-T lymphocytes were increased in all patients. A relationship was revealed between immunoregulatory Th/Ts index and clinical features of insulin-dependent diabetes. Autoantibodies to p64-68 kD andigenic complex were detected in 63-88% of patients with newly detected insulin-dependent diabetes.
Dedov
I I
II
Chugunova
L A
LA
Smirnova
O M
OM
Brykova
S V
SV
Shchegol'kova
T S
TS
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D008297:Male
D001323:Autoantibodies
Osobennosti kletochnogo immuniteta u bol'nykh s vpervye vyiavlennym insulinzavisimym sakharnym diabetom.