title: Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.
abstract: We have investigated the possible effect of estrogen on the metabolism of the Alzheimer amyloid precursor protein (APP). Using a cell line that contains high levels of estrogen receptors, we have found that treatment with physiological concentrations of 17 beta-estradiol is associated with accumulation in the conditioned medium of an amino-terminal cleavage product of APP (soluble APP or protease nexin-2), indicative of non-amyloidogenic processing. There were no obvious changes in the levels of intracellular immature or mature APP holoproteins, suggesting that estrogen may increase the secretory metabolism of APP.
authors.affiliation: Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021.
authors.forename: A B
authors.initials: AB
authors.lastname: Jaffe
authors.forename: C D
authors.initials: CD
authors.lastname: Toran-Allerand
authors.forename: P
authors.initials: P
authors.lastname: Greengard
authors.forename: S E
authors.initials: SE
authors.lastname: Gandy
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D017077:Culture Media, Conditioned; D004958:Estradiol / Q000502:physiology*; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D016564:Amyloid beta-Protein Precursor; D017077:Culture Media, Conditioned; D004958:Estradiol