[Role of hematopoiesis-inducing microenvironment in the regulation of hematopoiesis during myelosuppression of various origin].
The paper discusses the mechanisms of hemopoiesis regulation on the models of bone marrow hypoplasia induced by cyclophosphane, adriamycin, sublethal and lethal X-ray radiation followed by bone marrow transplantation. The findings suggest that there is the unique complexly organized system of local hemopoiesis regulation in the body (cell elements of the hemopoiesis-inducing microenvironment and their produced humoral factors) whose functional activity increases naturally under the action of different myelotoxic agents. The specific features of hemopoiesis-inducing microenvironmental functioning are largely determined by the extent and specificity of the damaging action of an agent on some individual components of the local regulation regulatory system.
Gol'dberg
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Dygaĭ
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AM
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D006410:Hematopoiesis / Q000502:physiology*; D051379:Mice
Rol' gemopoèzindutsiruiushchego mikrookryzheniia v reguliatsii krovetvoreniia pri mielodepressiiakh razlichnogo geneza.