Correlation between dioxin levels in adipose tissue and estimated exposure to Agent Orange in south Vietnamese residents.
To permit new epidemiologic studies of the effects of dioxin on humans in Vietnam, we evaluated a model for quantifying exposure to Agent Orange (exposure index) based on the residential histories of 27 Vietnamese subjects and on information about spraying from the U.S. Army records (Herbs Tape) and compared this index to the dioxin levels measured in the subjects' adipose tissue. The mean dioxin level was 7.8 ppt, and dioxin and furan isomer profiles were similar to those already reported in industrialized countries. In addition, there was a highly significant correlation between the levels of almost all the isomers, whatever their degree of chlorination. For the group of 27 subjects, we found a Pearson correlation coefficient of 0.36 (P = 0.07) between the dioxin levels and the exposure index after log-transformation of both variables. When the analysis was restricted to the 22 subjects with a positive exposure index, the Pearson correlation coefficient rose to 0.50 (P = 0.02). We conclude that despite the limitations and power conditions of the study, this result is encouraging because it will be useful for future epidemiologic studies in Vietnam.
Verger
P
P
Unit 170 of Epidemiological and Statistical Research on Health and Environment, National Institute of Health and Medical Research (INSERM), Villejuif, France.
Cordier
S
S
Thuy
L T
LT
Bard
D
D
Dai
L C
LC
Phiet
P H
PH
Gonnord
M F
MF
Abenhaim
L
L
D015085:2,4,5-Trichlorophenoxyacetic Acid; D015084:2,4-Dichlorophenoxyacetic Acid; D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000336:Aerosols; D000368:Aged; D000075182:Agent Orange; D003678:Defoliants, Chemical; D004147:Dioxins / Q000032:analysis*; D004781:Environmental Exposure; D005663:Furans / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072317:Polychlorinated Dibenzodioxins; D012044:Regression Analysis; D014744:Vietnam
D000336:Aerosols; D003678:Defoliants, Chemical; D004147:Dioxins; D005663:Furans; D000072317:Polychlorinated Dibenzodioxins; D015084:2,4-Dichlorophenoxyacetic Acid; D000075182:Agent Orange; D015085:2,4,5-Trichlorophenoxyacetic Acid