Chemotherapy induced myocardial fibrosis.
Alkylating agents have a well established role in the treatment of malignant disease, with well documented side effects. This case history, however, illustrates the susceptibility to these agents shown by some patients. It is suggested that, when drug induced pneumonitis is noted, careful screening of left ventricular function should be performed in order to diagnose myocardial fibrosis and subsequent cardiac failure.
Callaway
M P
MP
Manchester Royal Infirmary, UK.
Tyrrell
C J
CJ
Williams
M P
MP
Marshall
A J
AJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D004719:Endomyocardial Fibrosis / Q000139:chemically induced*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010494:Pericarditis, Constrictive / Q000139:chemically induced