Disruption of behavioral recovery by the anti-convulsant phenobarbital.
The effects of the anti-convulsant phenobarbital on recovery of function was assessed. Phenobarbital, which is frequently administered to humans after brain injury, was injected for 7 days beginning 48 h after unilateral cortex lesions in rats. Recovery from somatosensory deficits was significantly delayed in phenobarbital treated animals. These results provide additional evidence that anti-convulsants interfere with recovery when administered after brain damage.
Hernandez
T D
TD
Department of Psychology, University of Colorado, Boulder 80309.
Holling
L C
LC
D000818:Animals; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*; D010812:Physical Stimulation; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D010634:Phenobarbital