[Pharmacokinetic and clinical studies on fluconazole in the pediatric field].
Pharmacokinetic, bacteriological and clinical studies on intravenous fluconazole (FLCZ) in deep seated mycoses were performed involving 4 pediatric patients. Clinical and bacteriological assessments were made on 4 patients; clinical improvements were good in 3 patients and bacteriological efficacies were rated as "eradicated" in 3 patients. No side effects nor abnormal laboratory values were observed. The pharmacokinetics were investigated in 2 patients. Good serum FLCZ concentrations were obtained at an intravenous dose of 3-6 mg/kg daily. These results indicate that FLCZ is a useful drug in the treatment of pediatric patients with systemic deep-seated mycosis.
Sato
Y
Y
Department of Pediatrics, General Ota Hospital.
Iwata
S
S
Akita
H
H
Kobayashi
M
M
Yokota
T
T
Sunakawa
K
K
D000293:Adolescent; D002177:Candidiasis / Q000188:drug therapy*; D015725:Fluconazole / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male
D015725:Fluconazole