title: Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).
abstract: We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor. Bronchoalveolar lavage (BAL) revealed lymphocyte alveolitis with a low CD4/CD8 ratio (0.36), consistent with an immunoallergic phenomenon, rather than the most often evoked toxic hypothesis.
authors.affiliation: Department of Pneumology, Hôpital Pontchaillou-Centre Hospitalier Universitaire de Rennes, France.
authors.forename: H
authors.initials: H
authors.lastname: Lena
authors.forename: B
authors.initials: B
authors.lastname: Desrues
authors.forename: A
authors.initials: A
authors.lastname: Le Coz
authors.forename: M L
authors.initials: ML
authors.lastname: Quinquenel
authors.forename: P
authors.initials: P
authors.lastname: Delaval
mesh_terms: D000208:Acute Disease; D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy; D002330:Carmustine / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography
chemical_list: D002330:Carmustine