title: [Follow-up of arteriosclerosis-induced anterior ischemic optic neuropathy].
abstract: In 22 patients with acute arteriosclerotic anterior ischemic optic neuropathy (AION), examinations were conducted before the start of therapy and between 1 and 3 years later. In the acute stage of the disease the patients were treated with hemodilution for 10 days. The visual acuity improved from 0.2 to 0.4 (median). Compared with the visual acuity before therapy, at the follow-up 1-3 years later visual acuity had improved by 3 lines or more in 11 patients, remained stationary in 9 patients (+/- 1 line), and worsened in 2 patients by 3 lines or more. The visual fields (Goldmann) improved in 8 patients, did not change in 10 patients and worsened in 4 patients. After 1-3 years, 14 patients (64%) showed a sectorial pallor and 8 patients (36%) a diffuse pallor of the optic disc. Videofluorescein angiography revealed hypofluorescent discs in all patients. No difference in arm-retina time (ART) was found between the acute phase (13.0 +/- 3.3 s) and the examination 1-3 years later (13.1 +/- 2.2 s). ART was within normal limits in all patients. The arteriovenous passage time (AVP) dropped significantly, from 2.36 (+/- 0.81) s in the acute phase to 1.91 (+/- 0.56) s 1-3 years later. However, the AVP still did not fall to normal levels (1.45 +/- 0.40 s). Slowed retinal hemodynamics (AVP) with normal ART at the same time suggests a disturbance in microcirculation still present 1-3 years after the acute phase of AION. The rheological parameters (hematocrit, plasma viscosity, erythrocyte aggregation index) did not show any change between examinations.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Augenklinik, RWTH Aachen.
authors.forename: B
authors.initials: B
authors.lastname: Bertram
authors.forename: U
authors.initials: U
authors.lastname: Schulte-Stracke
authors.forename: S
authors.initials: S
authors.lastname: Wolf
authors.forename: K
authors.initials: K
authors.lastname: Schulte
authors.forename: O
authors.initials: O
authors.lastname: Arend
authors.forename: A
authors.initials: A
authors.lastname: Remky
authors.forename: M
authors.initials: M
authors.lastname: Reim
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000628:therapy; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000098:blood supply*; D009902:Optic Neuritis / Q000175:diagnosis* / Q000628:therapy; D012016:Reference Values
vernacular_title: Verlaufsbeobachtungen bei arteriosklerotischer anteriorer ischämischer Optikusneuropathie.