title: The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice.
abstract: B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies.
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill 27599-7280.
authors.forename: R A
authors.initials: RA
authors.lastname: Eisenberg
authors.forename: E S
authors.initials: ES
authors.lastname: Sobel
authors.forename: E A
authors.initials: EA
authors.lastname: Reap
authors.forename: M D
authors.initials: MD
authors.lastname: Halpern
authors.forename: P L
authors.initials: PL
authors.lastname: Cohen
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002454:Cell Differentiation; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D018183:Transplantation Chimera
chemical_list: D001323:Autoantibodies