title: The incidence of anticipatory nausea and vomiting after repeat cycle chemotherapy: the effect of granisetron.
abstract: Anticipatory nausea and vomiting (ANV) after repeated cycles of cytotoxic chemotherapy is thought to be a conditioned response to a conditioning stimulus. Good control of acute and delayed emesis may result in a lower incidence of ANV. We have analysed data from 574 chemotherapy patients who received granisetron as their antiemetic treatment during repeat cycle chemotherapy. Per treatment cycle, less than 10% of patients displayed symptoms of anticipatory nausea and 2% or less had symptoms of anticipatory vomiting. It is concluded that the use of granisetron as an antiemetic during the acute phase of chemotherapy may result in a lower incidence of ANV in patients undergoing repeat cycle chemotherapy.
authors.affiliation: Centre Anticancéreux, Genolier, Switzerland.
authors.forename: M S
authors.initials: MS
authors.lastname: Aapro
authors.forename: V
authors.initials: V
authors.lastname: Kirchner
authors.forename: J P
authors.initials: JP
authors.lastname: Terrey
mesh_terms: D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009325:Nausea / Q000517:prevention & control*; D012189:Retrospective Studies; D014840:Vomiting, Anticipatory / Q000517:prevention & control*
chemical_list: D017829:Granisetron