title: Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.
abstract: The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric beta-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.
authors.affiliation: Department of Microbiology, University of Minnesota, St. Paul 55108.
authors.forename: E S
authors.initials: ES
authors.lastname: Kim
authors.forename: M J
authors.initials: MJ
authors.lastname: Bibb
authors.forename: M J
authors.initials: MJ
authors.lastname: Butler
authors.forename: D A
authors.initials: DA
authors.lastname: Hopwood
authors.forename: D H
authors.initials: DH
authors.lastname: Sherman
mesh_terms: D000595:Amino Acid Sequence; D005798:Genes, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics*; D010118:Oxytetracycline / Q000096:biosynthesis*; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013302:Streptomyces / Q000201:enzymology* / Q000235:genetics
chemical_list: D009097:Multienzyme Complexes; D010118:Oxytetracycline