[Synthesis of 4-aryl-1-lambda-2, 2-lambda- 4-dithia-3,4-diaza-buta-1,2-dienes, a new dithiadiazabutadiene system].
4-Aryl-1 lambda 2, 2 lambda 4-dithia-3,4-diaza-buta-1,2-dienes 1a-12a as representatives of a dithiadiazabutadiene structure in which sulphur occupies a different oxidation number are synthesized by reaction of diazotated acceptor-substituted aryl- and hetarylamines 1-12 with thiosulfates or disodium disulfide in strong acid solution. For some examples a first pharmacological test indicate an immune-stimulating effect. Analytical examination as well as MNDO calculation which give some mechanistical insight, supplements the new synthesis.
Hess
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U
Fachbereich Pharmazie der Humboldt-Universität zu Berlin.
Homann
T
T
Komenda
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J
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010659:Phenylhydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman
D000276:Adjuvants, Immunologic; D010659:Phenylhydrazines
Synthese von 4-Aryl-1 lambda 2,2 lambda 4-dithia-3,4-diaza-buta- 1,2-dienen, einem neuen Dithiadiazabutadien-System.