Long-term potentiation of Aplysia sensorimotor synapses in cell culture: regulation by postsynaptic voltage.
Long-term potentiation (LTP) has been proposed as a cellular mechanism for associative learning in vertebrates. Induction of one type of LTP--observed at synapses in the CA1 region of the mammalian hippocampus--is regulated by the voltage of the postsynaptic cell. To date, a similar form of LTP has not been demonstrated for any invertebrate synapse. We now report that high-frequency stimulation can induce LTP of sensorimotor synapses of the marine mollusc Aplysia in cell culture. Moreover, induction of this form of LTP appears to involve a voltage-dependent postsynaptic mechanism because pairing tetanic stimulation of the presynaptic cell with strong hyperpolarization of the postsynaptic cell blocks the induction of LTP.
Lin
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Department of Physiological Science, University of California, Los Angeles 90024-1568.
Glanzman
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D000818:Animals; D001048:Aplysia; D002478:Cells, Cultured; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000502:physiology; D017952:Ganglia, Invertebrate / Q000502:physiology; D007448:Invertebrates; D017774:Long-Term Potentiation; D008322:Mammals; D009046:Motor Neurons / Q000166:cytology / Q000502:physiology*; D009475:Neurons, Afferent / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology