title: The Unp proto-oncogene encodes a nuclear protein.
abstract: The mouse Unp gene is related to TRE17, a human oncogene, but is not its mouse homolog. Unp is a ubiquitously expressed gene producing two related mRNAs. The protein product of Unp is localized in the nucleus. Expression of Unp from a highly active promoter results in tumorigenic transformation of NIH3T3 cells injected into athymic mice. Unp therefore encodes a novel nuclear oncoprotein.
authors.affiliation: Department of Biochemistry, University of Ottawa, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Gupta
authors.forename: M
authors.initials: M
authors.lastname: Chevrette
authors.forename: D A
authors.initials: DA
authors.lastname: Gray
mesh_terms: D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases
chemical_list: C000715470:MAS1 protein, human; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C082325:Usp4 protein, mouse; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases