title: The development of serotonergic projections to the olfactory bulb of Monodelphis domestica (the grey, short-tailed opossum).
abstract: The offspring of Monodelphis domestica (grey, short-tailed opossum) are born in a very immature state after a short (14-day) gestation period. As a result, they provide a useful mammalian model for examining quite early stages of brain maturation. The present study demonstrates that the onset and development of serotonergic (5-HT) projections to the Monodelphis olfactory bulb can be traced entirely after birth. 5-HT was visualized in tissue sections from postnatal day 5 (P5), P10, P20, P30, and adult opossums using avidin-biotin peroxidase immunocytochemistry. 5-HT afferent fibers are rare in the bulb until P10. Maturation occurs slowly, but by P30, 5-HT fibers assume the adult form characterized by preferential glomerular innervation. Due to the postnatal development, slow maturation, and specificity of innervation patterns, the Monodelphis bulb provides a model with which to study the regulation of serotonergic development.
authors.affiliation: Department of Psychology, University of Virginia, Charlottesville 22903.
authors.forename: B D
authors.initials: BD
authors.lastname: Philpot
authors.forename: A A
authors.initials: AA
authors.lastname: Jazaeri
authors.forename: P C
authors.initials: PC
authors.lastname: Brunjes
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001360:Avidin; D001710:Biotin; D007150:Immunohistochemistry; D007395:Interneurons / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000254:growth & development; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development*; D009893:Opossums / Q000254:growth & development*; D011903:Raphe Nuclei / Q000166:cytology / Q000254:growth & development*; D012701:Serotonin / Q000502:physiology*
chemical_list: D001360:Avidin; D012701:Serotonin; D001710:Biotin