A multicenter study on the prognosis of fulminant viral hepatitis: early prediction for liver transplantation.
To determine the risk of death at an early stage of fulminant viral hepatitis, we created severity indexes drawn from clinical data on the day of development of encephalopathy in 128 patients with fulminant hepatitis B and 103 with fulminant hepatitis non-A, non-B. In fulminant hepatitis B, the risk score was 2.75 x BL + 2.75 x BR + 2.7 x AG + 2.3 x WB + 1.67 x CD + 1.56 x AL - 0.098 x PR - 0.88, where BL is 1 if total bilirubin is higher than 20 mg/dl, BR is 1 if the ratio of total to direct bilirubin exceeds 2.2, AG is 1 if age is above 40 yr, WB is 1 if white blood cell count is less than 4,000 cells/mm3 or more than 18,000 cells/mm3, CD is 1 if a hazardous disease coexists and AL is 1 if ALT is less than 100 times the upper limit of normal (otherwise all are 0), and PR is prothrombin time (percentage of normal value). Using a cutoff score of 0, we found the positive predictive value, negative predictive value and predictive accuracy to be 0.90, 0.86 and 0.89, respectively. Sensitivity and specificity were 0.94 and 0.77, respectively. In fulminant non-A, non-B hepatitis, the risk score was 2.66 x BR + 2.25 x BL + 2.24 x DI + 2.05 x AL +/- 1.38 x AG + 0.00021 x WB - 6.33.(ABSTRACT TRUNCATED AT 250 WORDS)
Takahashi
Y
Y
Toranomon Hospital, Kawasaki, Japan.
Kumada
H
H
Shimizu
M
M
Tanikawa
K
K
Kumashiro
R
R
Omata
M
M
Ehata
T
T
Tsuji
T
T
Ukida
M
M
Yasunaga
M
M
D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D006501:Hepatic Encephalopathy / Q000209:etiology; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D016751:Hepatitis E / Q000175:diagnosis; D006801:Humans; D007564:Japan; D007958:Leukocyte Count; D016031:Liver Transplantation; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011517:Prothrombin Time; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D000410:Alanine Transaminase; D001663:Bilirubin