Antiatherosclerotic effects of fish extract feeding in rabbits.
The feeding of a fish extract, prepared by extracting whole fish with 80% ethanol, prevented abdominal, thoracic aorta and coronary atheroma in cholesterol-fed rabbits. Daily fish extract feeding reduced serum cholesterol and LDL-cholesterol levels by 41.8 and 38.0%, respectively. In addition, triglyceride levels were reduced by 52.8%. Hepatic and aortic contents of cholesterol and phospholipids approached normal levels in cholesterol-fed rabbits on the fish extract diet. Fish extract feeding induced a greater fecal excretion of cholesterol. Plaque formation was very little or absent in the aorta of fish-fed rabbits.
Gusain
D
D
Department of Zoology, University of Rajasthan, Jaipur, India.
Sharma
I
I
Dixit
V P
VP
D000818:Animals; D000924:Anticholesteremic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001011:Aorta / Q000378:metabolism; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003324:Coronary Artery Disease / Q000517:prevention & control*; D004036:Diet, Atherogenic; D005260:Female; D005395:Fish Oils / Q000302:isolation & purification / Q000627:therapeutic use*; D005399:Fishes; D008099:Liver / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D014280:Triglycerides / Q000378:metabolism
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D005395:Fish Oils; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol