title: Primary treatment of radiation-induced hemorrhagic cystitis with hyperbaric oxygen: 10-year experience.
abstract: Radiation-induced hemorrhagic cystitis continues to cause frustration for patients and urologists alike. Virtually all present modes of treatment tend to yield short-term benefits and entail potentially devastating risk by virtue of the tissue destructive nature. We report our 10-year experience in the treatment of hemorrhagic radiation cystitis with hyperbaric oxygen therapy, a tissue-reparative method, in followup of our prior reports. A total of 13 patients who previously underwent radiation therapy for various pelvic malignancies had endoscopically or biopsy proved hemorrhagic cystitis. All but 1 patient experienced durable cessation of hematuria with minimal side effects following hyperbaric oxygen therapy. These results suggest hyperbaric oxygen therapy to be a significant weapon in the armamentarium for treatment of hematuria secondary to radiation-induced injury to the bladder.
authors.affiliation: Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania.
authors.forename: J P
authors.initials: JP
authors.lastname: Weiss
authors.forename: D M
authors.initials: DM
authors.lastname: Mattei
authors.forename: E C
authors.initials: EC
authors.lastname: Neville
authors.forename: P M
authors.initials: PM
authors.lastname: Hanno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003556:Cystitis / Q000209:etiology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000628:therapy*; D001745:Urinary Bladder Diseases / Q000209:etiology / Q000628:therapy