The light organ symbiont Vibrio fischeri possesses a homolog of the Vibrio cholerae transmembrane transcriptional activator ToxR.
A cross-hybridizing DNA fragment to Vibrio cholerae toxR was cloned from the nonpathogenic light organ symbiont Vibrio fischeri, and three proteins homologous to V. cholerae ToxR, ToxS, and HtpG were deduced from its DNA sequence. V. fischeri ToxR was found to activate a V. cholerae ToxR-regulated promoter, and an antiserum raised against the amino-terminal domain of V. cholerae ToxR cross-reacts V. fischeri ToxR.
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Department of Microbiology and Immunology, Stanford University Medical School, California 94305-5428.
Schoolnik
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D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D002772:Cholera Toxin / Q000096:biosynthesis / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000235:genetics; D008027:Light; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D014176:Protein Biosynthesis; D017386:Sequence Homology, Amino Acid; D013559:Symbiosis / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014733:Vibrio / Q000235:genetics* / Q000472:pathogenicity*; D014734:Vibrio cholerae / Q000235:genetics; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D014157:Transcription Factors; C499324:toxR protein, Vibrio cholerae; C066719:toxR protein, bacteria; C066828:ToxS protein, Vibrio cholerae; D002772:Cholera Toxin