title: Limited-sampling models for anticancer agents.
abstract: Pharmacokinetic parameters of antineoplastic drugs are usually generated from concentration/time profiles obtained after multiple venipunctures. With limited-sampling models (LSM) this number can be reduced to between one and three timed plasma samples. LSMs may facilitate population pharmacokinetic/pharmacodynamic studies, which eventually may lead to a dosing strategy based on the characteristics of the individual patient. In this article, the development, validation and application of several LSMs reported in the literature are reviewed.
authors.affiliation: Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: van Warmerdam
authors.forename: W W
authors.initials: WW
authors.lastname: ten Bokkel Huinink
authors.forename: R A
authors.initials: RA
authors.lastname: Maes
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D008954:Models, Biological; D012494:Sampling Studies; D013223:Statistics as Topic
chemical_list: D000970:Antineoplastic Agents