Glial and neuronoglial malformative lesions associated with medically intractable epilepsy.
In a large series of 116 cortical resections for treatment of medically intractable epilepsy, 10 glial hamartomas and 11 neuronoglial malformative lesions were found. Glial hamartomas were astrocytic in 3 cases, oligodendrocytic in 6 and mixed oligoastrocytic in 1. Neuronoglial lesions corresponded to "focal cortical dysplasia" in 6 patients and to "microdysgenesis" in 5 others. This study focuses on the various neuropathological presentations of these malformative epileptogenic lesions, and on correlations with neuro-imaging data.
Vital
A
A
Department of Neurology, Bordeaux II University, France.
Marchal
C
C
Loiseau
H
H
Rougier
A
A
Pedespan
J M
JM
Rivel
J
J
Vital
C
C
D000293:Adolescent; D000328:Adult; D001253:Astrocytes / Q000648:ultrastructure; D001921:Brain / Q000002:abnormalities; D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology; D002648:Child; D004827:Epilepsy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006222:Hamartoma / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure*