Effectiveness of disodium cromoglycate in food-dependent, exercise-induced anaphylaxis: a case report.
An 18-year-old girl experienced anaphylactic reactions three times and frequent urticaria with exercise after meals that included wheat. Allergy evaluation showed a strong prick test reaction to wheat, and RAST score was 2 for wheat. Exercise provoked a decrease of FEV1 of 7.4% and increase of plasma histamine with no symptoms. Exercise after eating wheat provoked an FEV1 decrease of more than 18.7%, further increase of plasma histamine, urticaria and mild dyspnea. Oral administration of disodium cromoglycate before ingestion of bread and exercise challenge caused a maximal FEV1 increase of 6%, no increase of the plasma histamine, and no symptoms.
Juji
F
F
Department of Pediatrics, Faculty of Medicine, University of Tokyo, Japan.
Suko
M
M
D000293:Adolescent; D000707:Anaphylaxis / Q000209:etiology* / Q000517:prevention & control*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D015444:Exercise; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D005541:Forced Expiratory Volume; D006632:Histamine / Q000097:blood; D006801:Humans; D014581:Urticaria / Q000209:etiology
D006632:Histamine; D004205:Cromolyn Sodium