title: Assay of oral vaccination of dogs against rabies in Tunisia with the vaccinal strain SADBern.
abstract: The possibility of immunizing dogs orally against rabies, using SADBern, an attenuated strain, was tested on dogs in the field in Tunisia. This strain induced high neutralizing antibody titres and conferred to all vaccinated dogs total resistance against a challenge with a Maghrebian strain. However, an excretion of virus of vaccinal origin was observed in one dog, hampering the use of SADBern in dogs. Nevertheless, this work demonstrates for the first time that dogs in developing countries, especially those which are inaccessible to parenteral vaccination, could be efficiently immunized against rabies by the oral route.
authors.affiliation: Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Laboratoire de Microbiologie et d'Immunologie, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Haddad
authors.forename: R
authors.initials: R
authors.lastname: Ben Khelifa
authors.forename: H
authors.initials: H
authors.lastname: Matter
authors.forename: H
authors.initials: H
authors.lastname: Kharmachi
authors.forename: M F
authors.initials: MF
authors.lastname: Aubert
authors.forename: A
authors.initials: A
authors.lastname: Wandeler
authors.forename: J
authors.initials: J
authors.lastname: Blancou
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004199:Disease Vectors; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D051379:Mice; D009500:Neutralization Tests / Q000662:veterinary; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage*; D012463:Saliva / Q000382:microbiology; D014416:Tunisia; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated