title: The nuclear genomes of African and American trypanosomes are strikingly different.
abstract: We have investigated the compositional distributions of exons and their different codon positions, as well as the codon usage and amino-acid (aa) composition of the nuclear genomes of the African and American trypanosomes Trypanosoma brucei and T. cruzi. Very large differences between the two species were found in all the properties investigated. The most striking differences concern the compositional distributions of third codon positions and the extremely large nucleotide divergence of third codon position for homologous genes encoding proteins that are highly conserved in their aa sequences. Moreover, if coding sequences from each species are divided into two groups according to the GC levels in third codon positions, very different codon usages and aa compositions are found. This indicates a compositional compartmentalization in both genomes which had previously been detected in T. brucei (and T. equiperdum) by compositional fractionation.
authors.affiliation: Laboratoire de Génétique Moléculaire, Institut Jacques Monod, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Musto
authors.forename: H
authors.initials: H
authors.lastname: Rodríguez-Maseda
authors.forename: G
authors.initials: G
authors.lastname: Bernardi
mesh_terms: D000818:Animals; D001482:Base Composition; D003062:Codon / Q000235:genetics; D016054:DNA, Protozoan / Q000737:chemistry*; D005091:Exons / Q000235:genetics; D017125:Genes, Protozoan; D016678:Genome; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014346:Trypanosoma brucei brucei / Q000235:genetics*; D014349:Trypanosoma cruzi / Q000235:genetics*
chemical_list: D003062:Codon; D016054:DNA, Protozoan