title: Oncology and hematology.
abstract: Net overexpression or derangements of PTK-encoding oncogenes and ras serve as critical driving forces in the evolution of many epithelial and lymphohematopoietic cancers. The ability to impede signal transduction through ras-based pathways could provide a powerful molecular target for therapy and prevention of a broad spectrum of malignant neoplasms.
authors.affiliation: National Cancer Institute, Bethesda, Md.
authors.forename: J E
authors.initials: JE
authors.lastname: Karp
authors.forename: S
authors.initials: S
authors.lastname: Broder
mesh_terms: D006405:Hematology / Q000639:trends*; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009857:Oncogenes; D014481:United States