Widenings of the myelin lamellae in a typical Guillain-Barré syndrome.
The so-called "widening of the myelin lamellae" are thought to be specific ultrastructural features of peripheral nerve myelin in patients with peripheral neuropathy associated with a monoclonal dysglobulinemia of IgM type and antiglycolipid activity. We report here a case of Guillain-Barré syndrome with no evidence of serum monoclonal dysglobulinemia, presenting the typical widenings of the myelin lamellae in small-diameter myelinated fibers from a sural nerve biopsy. In view of the positive reaction with anti-C3d complement on direct immunofluorescence, an immunological mechanism may be involved in the widenings of the myelin lamellae.
Vallat
J M
JM
Department of Neurology, University Hospital, Limoges, France.
Leboutet
M J
MJ
Jauberteau
M O
MO
Tabaraud
F
F
Couratier
P
P
Akani
F
F
D001369:Axons / Q000473:pathology / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology / Q000648:ultrastructure*; D009431:Neural Conduction; D011129:Polyradiculoneuropathy / Q000473:pathology* / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology / Q000648:ultrastructure*