Electrophysiological evaluation of the effects of naftidrofuryl on skeletal muscle reinnervation in the rat.
The effects of naftidrofuryl on the reinnervation of the rat gastrocnemius muscle after its denervation by localized freezing of the sciatic nerve were tested with electrophysiological techniques. Daily intraperitoneal injections of 30 mg/kg of naftidrofuryl do not increase the rate of axonal regeneration since early signs of reinnervation appeared as in controls around the 10th day after surgery. However, axonal sprouting is markedly increased since the percentage of muscle fibers with polyneuronal innervations was almost twice as high as in controls at the 15 and 21 day postoperative stages. The promoting effects of naftidrofuryl on polyneuronal innervation which gives rise to a redundant innervation during the first period of reinnervation constitutes an improvement of motor function which might be efficient for treatment of nerve injury and neuropathies.
Pécot-Dechavassine
M
M
Institut des Neurosciences (URA CNRS 1488), Département de Neurobiologie des Signaux Intercellulaires, Université Paris VI, France.
Mira
J C
JC
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D004576:Electromyography / Q000187:drug effects; D005071:Evoked Potentials / Q000502:physiology; D008297:Male; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation*; D009257:Nafronyl / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D010919:Placebos; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D013997:Time Factors
D010919:Placebos; D009257:Nafronyl