title: Inadequate superoxide production by canine neutrophils in response to the combination of N-formyl-methionyl-leucyl-phenylalanine and cytochalasin B.
abstract: The formylated peptide, N-formyl-methionyl-leucyl-phenylalanine, at concentration of 0.22 microM, failed to stimulate canine neutrophils to produce adequate amounts of superoxide. Furthermore, addition of cytochalasin B did not augment superoxide generation appreciably.
authors.affiliation: Department of Medicine, Veterans Affairs Hospital, Hines, IL.
authors.forename: T S
authors.initials: TS
authors.lastname: Ing
authors.forename: A W
authors.initials: AW
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: V
authors.initials: V
authors.lastname: Gupta
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Agrawal
authors.forename: P
authors.initials: P
authors.lastname: Patel
mesh_terms: D000328:Adult; D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology*; D004285:Dogs / Q000097:blood*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000097:blood*; D015054:Zymosan / Q000494:pharmacology
chemical_list: D013481:Superoxides; D003571:Cytochalasin B; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015054:Zymosan