title: Acute renal failure after intravenous immunoglobulin therapy.
abstract: We describe 3 patients given intravenous immunoglobulin (IVIG) who developed acute renal failure temporally related to IVIG therapy. The rise in BUN and creatinine appeared to be transient and reversible 8-14 days after discontinuation of the drug. Renal dysfunction was mild in 2 patients but was severe in one who presented with azotemia, worsening congestive heart failure, severe hyponatremia, hyperkalemia, and metabolic acidosis necessitating hemodialysis. Renal dysfunction was not associated with a specific immunoglobulin preparation or dose.
authors.affiliation: Department of Medicine, Medical College Hospital, Philadelphia, PA 19129.
authors.forename: A M
authors.initials: AM
authors.lastname: Pasatiempo
authors.forename: J A
authors.initials: JA
authors.lastname: Kroser
authors.forename: M
authors.initials: M
authors.lastname: Rudnick
authors.forename: B I
authors.initials: BI
authors.lastname: Hoffman
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology*; D000368:Aged; D001806:Blood Urea Nitrogen; D003240:Connective Tissue Diseases / Q000628:therapy; D003404:Creatinine / Q000097:blood; D005260:Female; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D008875:Middle Aged; D013997:Time Factors
chemical_list: D016756:Immunoglobulins, Intravenous; D003404:Creatinine