title: 5-Fluorouracil combined with the pure [6S]-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: a phase I-II study of two consecutive regimens.
authors.affiliation: Department of Oncology, Hospital Tenon, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Machover
authors.forename: X
authors.initials: X
authors.lastname: Grison
authors.forename: E
authors.initials: E
authors.lastname: Goldschmidt
authors.forename: J
authors.initials: J
authors.lastname: Zittoun
authors.forename: J P
authors.initials: JP
authors.lastname: Lotz
authors.forename: G
authors.initials: G
authors.lastname: Metzger
authors.forename: J
authors.initials: J
authors.lastname: Richaud
authors.forename: L
authors.initials: L
authors.lastname: Hannoun
authors.forename: J
authors.initials: J
authors.lastname: Marquet
authors.forename: T
authors.initials: T
authors.lastname: Guillot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000008:administration & dosage; D005492:Folic Acid / Q000097:blood / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage; D013237:Stereoisomerism
chemical_list: D011743:Pyrimidines; D005492:Folic Acid; D002955:Leucovorin; D005472:Fluorouracil