[The effect of pyrazidol on animal status and on the monoamine level in periodic hypobaric hypoxia].
The effects of 3 and 10-day intermittent hypoxia corresponding to the altitude 5000 m, during 4 hrs a day, were studied. Daily administration of pyrazidol exerted a normalising effect on the plasma total peroxidase activity, extra erythrocyte hemoglobin concentration and adrenal ascorbic acid content. Unprotected rats developed a 2-fold reduction of the body mass under the 10-day hypoxia. Administration of pyrazidol normalises catecholamines content in the hypothalamus and brain cortex in the 3-day hypoxia, prevents a monoamine content decrease in the hypothalamus and adrenals in the 10-day hypoxia, promotes a serotonin increase in the brain areas. Adrenal norepinephrine content was twice as large in the protected animals than in unprotected those. An adaptogenic role of pyrazidol under conditions of an intermittent hypoxia is discussed.
Goroshinskaia
I A
IA
Nemashkalova
L A
LA
Khodakova
A A
AA
Sorokina
I V
IV
D000311:Adrenal Glands / Q000737:chemistry / Q000187:drug effects; D000818:Animals; D001273:Atmosphere Exposure Chambers; D015306:Biogenic Monoamines / Q000032:analysis / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D010507:Periodicity; D051381:Rats
D015306:Biogenic Monoamines; D002227:Carbazoles; D008996:Monoamine Oxidase Inhibitors; C009830:pirlindole
Vliianie pirazidola na sostoianie zhivotnykh i soderzhanie monoaminov pri periodicheskoĭ gipobaricheskoĭ gipoksii.