title: Loosening of a noncemented porous-coated anatomic femoral component in Gaucher's disease. A case report and review of literature.
abstract: There are few reports of experiences with hip arthroplasty in patients with Gaucher's disease. Review of the literature shows a high rate of loosening after any type of arthroplasty. The clinical, roentgenographic and histopathological findings of a porous-coated hip arthroplasty in Gaucher's disease necessitating revision after 5 years are reported. Because we found typical lipid-laden Gaucher cells at the bone prosthesis interface we support the hypothesis that loosening in Gaucher's disease is due to continued Gaucher cell proliferation and erosion of bone. Loosening seems to be related to the disease and not to a specific type of prosthetic component.
authors.affiliation: Department of Orthopaedics and Traumatology, Akademisch Ziekenhuis VUB, Free University of Brussels, Belgium.
authors.forename: P A
authors.initials: PA
authors.lastname: van Wellen
authors.forename: P
authors.initials: P
authors.lastname: Haentjens
authors.forename: N
authors.initials: N
authors.lastname: Frecourt
authors.forename: P
authors.initials: P
authors.lastname: Opdecam
mesh_terms: D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D005271:Femur Head Necrosis / Q000150:complications / Q000601:surgery*; D005776:Gaucher Disease / Q000150:complications* / Q000473:pathology; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D012086:Reoperation