title: Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.
abstract: A strictly anaerobic bacterium capable of metabolizing sennosides was isolated from human feces and identified as Bifidobacterium sp., named strain SEN. The bacterium hydrolyzed sennosides A and B to sennidins A and B via sennidin A and B 8-monoglucosides, respectively. Among nine species of Bifidobacterium having beta-glucosidase activity, only Bifidobacterium dentium and B. adolescentis metabolized sennoside B to sennidin B, suggesting that the sennoside-metabolizing bacteria produce a novel type of beta-glucosidase capable of hydrolyzing sennosides to sennidins.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Akao
authors.forename: Q M
authors.initials: QM
authors.lastname: Che
authors.forename: K
authors.initials: K
authors.lastname: Kobashi
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Namba
mesh_terms: D000873:Anthracenes / Q000378:metabolism*; D000880:Anthraquinones / Q000378:metabolism*; D001644:Bifidobacterium / Q000302:isolation & purification / Q000378:metabolism*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D006868:Hydrolysis; D012676:Senna Extract; D000081226:Sennosides; D013045:Species Specificity
chemical_list: D000873:Anthracenes; D000880:Anthraquinones; D000081226:Sennosides; C013946:dihydroxydianthrone; D012676:Senna Extract