title: Novel nematocidal agents from Curcuma comosa.
abstract: Curcuma comosa is a member of the economically important plant family, Zingiberaceae. A methanolic extract of C. comosa was shown to be nematocidal when tested against the free-living nematode Caenorhabditis elegans. Five diphenylheptanoids [1-5], one new and four known, have been isolated and shown to be responsible for the activity. This is the first report of three of these compounds [1, 2, 4] being isolated from a natural source.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065.
authors.forename: T M
authors.initials: TM
authors.lastname: Jurgens
authors.forename: E G
authors.initials: EG
authors.lastname: Frazier
authors.forename: J M
authors.initials: JM
authors.lastname: Schaeffer
authors.forename: T E
authors.initials: TE
authors.lastname: Jones
authors.forename: D L
authors.initials: DL
authors.lastname: Zink
authors.forename: R P
authors.initials: RP
authors.lastname: Borris
authors.forename: W
authors.initials: W
authors.lastname: Nanakorn
authors.forename: H T
authors.initials: HT
authors.lastname: Beck
authors.forename: M J
authors.initials: MJ
authors.lastname: Balick
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D017173:Caenorhabditis elegans / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000032:analysis / Q000633:toxicity; D010944:Plants / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000969:Antinematodal Agents; D010936:Plant Extracts; D003474:Curcumin