title: High frequency of contact allergy to gold sodium thiosulfate. An indication of gold allergy?
abstract: When gold sodium thiosulfate was added to the patch test standard series, positive reactions were obtained in 8.6% of 823 consecutive patients with suspect contact allergy. The test reactions were clinically of an allergic type and, in several cases, long-lasting. There was no correlation with other allergens in the standard series. In a special study on 38 patients with contact allergy to gold sodium thiosulfate, the following principal findings were obtained: positive patch tests to the compound itself in dilute concentration; positive patch tests to potassium dicyanoaurate; negative patch tests to gold sodium thiomalate, sodium thiosulfate, and metallic gold; positive intradermal tests to gold sodium thiosulfate. Our findings make gold sodium thiosulfate the 2nd most common contact allergen after nickel sulfate. It is suggested that a positive skin test to gold sodium thiosulfate represents gold allergy.
authors.affiliation: Department of Occupational Dermatology, Malmö General Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Björkner
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: H
authors.initials: H
authors.lastname: Möller
mesh_terms: D000328:Adult; D003485:Cyanates / Q000008:administration & dosage; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology*; D005260:Female; D006046:Gold / Q000008:administration & dosage / Q000009:adverse effects*; D006047:Gold Alloys / Q000008:administration & dosage; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage; D012971:Gold Sodium Thiosulfate / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010577:Petrolatum; D013885:Thiosulfates / Q000008:administration & dosage; D014867:Water
chemical_list: D003485:Cyanates; D006047:Gold Alloys; D013885:Thiosulfates; C043041:gold cyanide; D014867:Water; D006052:Gold Sodium Thiomalate; D006046:Gold; D010577:Petrolatum; D012971:Gold Sodium Thiosulfate; C017717:sodium thiosulfate