title: Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218.
authors.forename: G H
authors.initials: GH
authors.lastname: Posner
authors.forename: C H
authors.initials: CH
authors.lastname: Oh
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Gerena
authors.forename: W K
authors.initials: WK
authors.lastname: Milhous
authors.forename: S R
authors.initials: SR
authors.lastname: Meshnick
authors.forename: W
authors.initials: W
authors.lastname: Asawamahasadka
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D037621:Artemisinins; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008745:Methylation; D015394:Molecular Structure; D010545:Peroxides; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D006571:Heterocyclic Compounds; D010545:Peroxides; D012717:Sesquiterpenes; C087349:octahydro-9-hydroxyethyl-1-methoxy-3,4,4-trimethyl-1H-3,9a-peroxy-2-benzoxepin; C031327:artemisinin