title: Effect of alcohol on glucose, insulin, free fatty acid and triacylglycerol responses to a light meal in non-insulin-dependent diabetic subjects.
abstract: Alcohol accounts for 4-6% of the average energy intake in most Western countries. Alcohol-induced hypoglycaemia is a well-known and feared complication in insulin-dependent diabetic subjects, but little attention has been paid to the impact of alcohol on carbohydrate metabolism in non-insulin-dependent diabetes. The aim of the present study was to investigate in non-insulin-dependent diabetic subjects the acute metabolic effects of a moderate amount of alcohol taken with a light meal, conditions chosen to mimic an everyday situation. The patients received 500 ml non-alcoholic beer with an alcohol content (ml/l) of 0 (treatment A) and 54 (treatment B) together with a light meal, implying identity of the contents of ingredients except for alcohol. We found similar serum glucose, insulin, free fatty acid and triacylglycerol responses irrespective of addition of a modern amount of alcohol. In conclusion, a moderate amount of alcohol can be taken with a meal without eliciting hypoglycaemia in non-insulin-dependent diabetic subjects.
authors.affiliation: Institute of Clinical Experimental Research, Aarhus University, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
authors.forename: C
authors.initials: C
authors.lastname: Thomsen
authors.forename: O
authors.initials: O
authors.lastname: Rasmussen
authors.forename: C
authors.initials: C
authors.lastname: Hauerslev
authors.forename: M
authors.initials: M
authors.lastname: Balle
authors.forename: C
authors.initials: C
authors.lastname: Hansen
authors.forename: K
authors.initials: K
authors.lastname: Hermansen
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D004435:Eating / Q000502:physiology*; D000431:Ethanol / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D000431:Ethanol