Familial ovarian carcinoma: pedigree studies and preliminary results from linkage analysis.
Thirty-seven ovarian cancer-prone families have been identified through a French co-operative network. Three main clinical presentations were observed: site-specific ovarian cancer, breast/ovarian carcinoma syndrome and Lynch syndrome II. An additional kindred with features of Li-Fraumeni syndrome is reported. It is expected that a better understanding of the mechanisms of carcinogenesis will allow the development of new methods of screening and treatment. With this aim, recent studies have mapped the gene for early-onset familial breast cancer and breast/ovarian carcinoma syndrome to the same locus in the chromosome 17q12-q23 region. Results from linkage analysis of two breast/ovarian carcinoma families and three breast cancer families favour the hypothesis of genetic heterogeneity among breast and ovarian tumors.
Sobol
H
H
Département de médecine, centre Léon-Bérard, Lyon, France.
Mazoyer
S
S
Smith
S A
SA
Lyonnet
D
D
Bignon
Y J
YJ
Narod
S A
SA
Ardoin
A
A
Biron
P
P
Bobin
J Y
JY
Bremond
A
A
D000328:Adult; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics*; D010375:Pedigree