Facial clefts in the west of Scotland in the period 1980-1984: epidemiology and genetic diagnoses.
Two hundred and eighty six cases of cleft lip, cleft palate, or both were identified in a study attempting complete ascertainment of babies with facial clefts born to women resident in the west of Scotland in a five year period beginning 1 January 1980. The total birth prevalence (TBP) of these defects over this period was 1.53 per 1000. The TBP for cleft lip with or without cleft palate (CL[P] was 0.74 per 1000 and for cleft palate (CP) was 0.79 per 1000; 26% of CL[P] and 39.5% of CP cases had one or more major congenital anomaly associated with their facial cleft and in over half of these cases a specific genetic or syndrome diagnosis could be made. In comparison to previous European reports this study shows a high incidence of associated abnormalities and a remarkably low ratio of CL[P]:CP cases.
FitzPatrick
D R
DR
Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow, UK.
Raine
P A
PA
Boorman
J G
JG
D000015:Abnormalities, Multiple; D002971:Cleft Lip / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D002972:Cleft Palate / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant / Q000502:physiology; D005808:Genes, Recessive / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012606:Scotland / Q000453:epidemiology; D017678:Sex Distribution; D013577:Syndrome