Magnetically responsive photosensitizing reagents for possible use in photoradiation therapy.
The ability of a magnetically responsive material to function as a carrier for photosensitizing agents for use in photoradiation therapy (PRT) has been examined in vitro. The photosensitizer has been attached to the magnetically responsive matrix (Dynabeads) by non-specific adsorption, Intralipid-mediated adsorption and poly-L-lysine mediated adsorption. In these studies, it has been demonstrated that conditions of attachment of photosensitizer to the matrix may be adapted in order to facilitate a diffuse or highly localized photo-toxic effect on target cells in vitro. The authors believe that this system may represent a novel approach to targeting photosensitizing agents to specific areas, thereby circumventing some of the problems associated with conventional photoradiation therapy (PRT), particularly in hollow organs.
Flynn
G
G
Department of Biological and Biomedical Sciences, University of Ulster, Coleraine, Co. Londonderry, Northern Ireland, UK.
Hackett
T J
TJ
McHale
L
L
McHale
A P
AP
D006367:HeLa Cells; D017324:Hematoporphyrin Derivative / Q000008:administration & dosage; D006801:Humans; D066298:In Vitro Techniques; D008280:Magnetics; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents; D011107:Polylysine / Q000008:administration & dosage
D017319:Photosensitizing Agents; D011107:Polylysine; D017324:Hematoporphyrin Derivative