[Angiotensins in the mechanisms of drinking, feeding and alcohol motivations].
In the paper was described the influence of angiotensin-2, captopril, bestatin, and angiotensin-2-(3-7) fragment on drinking, feeding and alcohol directed behaviour. It was found that dipsogenic doses of angiotensin-2 could inhibit food and alcohol intake mostly by a suppression of food and alcohol motivations. Specific antagonist of "classical" angiotensin-2 receptors saralasin could not block angiotensin-2 effects. A significant decrease of food and ethanol intake was revealed after intraventricular injections of enzyme blockers captopril and bestatin, which increase endogenic levels of angiotensin-1 and angiotensin-3, and also angiotensin-2-(3-7). So was shown the ability of angiotensins to suppress the dominant food or alcohol motivations by the activation of some other but not the "classical" angiotensin-2 receptors. Was suggested the involvement of angiotensins in the coordination of the different kinds of functional systems to create the optimal conditions for realization of drinking behaviour.
Kelesheva
L F
LF
D000428:Alcohol Drinking / Q000503:physiopathology*; D000626:Aminopeptidases / Q000037:antagonists & inhibitors; D000802:Angiotensin Amide / Q000494:pharmacology; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D009042:Motivation; D010446:Peptide Fragments; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012504:Saralasin / Q000494:pharmacology; D013997:Time Factors
D010446:Peptide Fragments; D000804:Angiotensin II; C069545:angiotensin II (3-7); D000802:Angiotensin Amide; D002216:Captopril; D000626:Aminopeptidases; D007930:Leucine; D012504:Saralasin; C012211:ubenimex
Angiotenziny v mekhanizmakh pit'evoĭ, pishchevoĭ i alkogol'noĭ motivatsii.