title: The Jarisch-Herxheimer reaction in leptospirosis.
abstract: Three patients with leptospirosis whose condition worsened after initiation of antibiotic therapy are reported. Their clinical deterioration appeared to be due to the development of the Jarisch-Herxheimer reaction rather than to progression of their underlying infection. Relevant aspects of the management of patients with leptospirosis are discussed.
authors.affiliation: Cork Regional Hospital, Department of Medicine, Wilton, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Vaughan
authors.forename: C C
authors.initials: CC
authors.lastname: Cronin
authors.forename: E K
authors.initials: EK
authors.lastname: Walsh
authors.forename: M
authors.initials: M
authors.lastname: Whelton
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D007022:Hypotension / Q000209:etiology*; D007922:Leptospirosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011674:Pulse
chemical_list: D000900:Anti-Bacterial Agents