[The effects of persantine on pulmonary arterial pressure of rats exposed to hypoxia].
In the chronic hypoxic model of pulmonary hypertension, the increased wall thickness can be attributed in part to proliferation of endothelial cells, medial smooth muscle cell, and adventitial fibroblasts. The cellular mechanisms responsible for this proliferative response to chronic hypoxia may be due to the action of specific growth factors released in areas of vascular injury. Some growth factors such as platelet-derived growth factor and epidermal growth factor, released from activated platelets at sites of tissue injury and thrombus formation, may play a crucial role in this proliferative process. This paper reported the effects of persantine (dipyridamole), an inhibitor of platelet function, on pulmonary arterial pressure of rats exposed to hypoxia for 2 weeks. The results showed that persantine could prevent elevation of pulmonary arterial pressure and increase of right ventricle weight of hypoxic rats.
Ran
P X
PX
Research Department of Respiratory Disease, Tongji Hospital, Tongji Medical University, Wuhan.
Duan
S F
SF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000503:physiopathology / Q000517:prevention & control*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004176:Dipyridamole