[Inefficiency of synthetic phenolic antioxidants in rats with nephrotoxic nephritis].
The therapeutic effects of the phenolic antioxidants alpha-tocopherol, potassium phenosan and ionol were investigated in rats with nephrotoxic nephritis (NN). The antioxidants were given to the animals during the first 15 days of NN in the maximal doses being 50 mg/kg, 10 mg/kg and 60 mg/kg, respectively. alpha-Tocopherol and ionol were given to the rats 14 days and 3 days, respectively before NN was induced. The biochemical and histological evidence suggests that the antioxidants studied had no effect on NN. In contrast, methylprednisolone, given for 15 days in dose of 4 mg/kg exerted a pronounced therapeutic effect in the autologous phase of NN. Concurrent treatment of the rats with both methylprednisolone and potassium phenosan did not enhance a therapeutic hormonal effect.
Nikiforova
N V
NV
Kirpatovskiĭ
V I
VI
Perepechkina
N P
NP
Gladskikh
O P
OP
Ivanov
A A
AA
Plekhanova
L G
LG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D008297:Male; D009393:Nephritis / Q000139:chemically induced / Q000188:drug therapy*; D010636:Phenols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D010636:Phenols
Neéffektivnost' sinteticheskikh fenol'nykh antioksidantov pri nefroticheskom nefrite u krys.