title: Different effects of cold exposure and cold acclimation on rat liver mitochondrial fatty acid oxidation and ketone bodies production.
abstract: 1. We have studied fatty acid oxidation and ketone bodies production in liver mitochondria from rats exposed to cold for 10 days and in rats adapted to cold for 40 days. We have examined State 3 respiration and ketone bodies production with palmitoylcarnitine as substrate in isolated mitochondria, together with mitochondrial protein mass and hepatocyte oxygen consumption. 2. Mitochondrial protein mass increases both in cold exposed and in cold adapted rats. 3. State 3 respiration and hepatocyte respiration increase only in cold exposed rats. 4. Ketone bodies production increases in cold adapted rats. 5. Taken together, our results suggest that the increased hepatic mitochondrial protein mass and the increased fatty acid oxidation subserve two different roles: an increase in ATP production in cold exposed rats and an increase in ketone bodies production in cold adapted rats.
authors.affiliation: Dipartimento di Fisiologia Generale ed Ambientale, Università di Napoli, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Iossa
authors.forename: A
authors.initials: A
authors.lastname: Barletta
authors.forename: G
authors.initials: G
authors.lastname: Liverini
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000818:Animals; D001481:Basal Metabolism / Q000502:physiology; D003080:Cold Temperature / Q000009:adverse effects*; D005227:Fatty Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D007657:Ketone Bodies