title: Identification and semi-quantification of estrogen and progesterone receptors in peripheral giant cell lesions of the jaws.
abstract: Cases of peripheral giant cell lesions of the jaws (PGCL) were evaluated for the detection of estrogen and progesterone receptor proteins (ERS/PRS) utilizing immunoperoxidase staining. Staining for ERS was strongly positive in three cases when examining the mononuclear cell population. Another two cases were weakly positive. In addition, an occasional ER + multinucleated giant cell could be observed in three of the cases examined. PRS immunoreactivity was essentially negative in all cases. It is well known that the PGCL has a marked female predilection. This, coupled with the present findings, gives further evidence that some PGCL may be at least partially under hormonal influence.
authors.affiliation: Department of Oral Diagnosis and Patient Services, School of Dentistry, Medical College of Georgia, Augusta.
authors.forename: S B
authors.initials: SB
authors.lastname: Whitaker
authors.forename: J E
authors.initials: JE
authors.lastname: Bouquot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006101:Granuloma, Giant Cell / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007571:Jaw Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012737:Sex Factors
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone