[Macrophage interaction with Candida albicans in immunodepression].
The interaction of fungi of the species C. albicans with macrophages has been studied in vivo under the conditions of immunosuppression resulting from the action of immunosuppressive agents, belonging to different groups with respect to the chemical nature and mechanism of their action (cyclophosphamide, azathioprine, hydrocortisone acetate, methotrexate, cyclosporin A). The data obtained in this study indicate that under the conditions of immunity disturbances macrophages have decreased functional activity. Azathioprine and cyclosporin A have the greatest inhibiting influence on macrophages during their interaction with fungi, while cyclophosphamide has the least influence.
Pakhomova
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Bykov
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D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000276:immunology*; D003864:Depression, Chemical; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D007166:Immunosuppressive Agents
Vzaimodeĭstvie makrofagov s Candida albicans pri immunodepressii.