title: Sequence rearrangements in the upstream regulatory region of human papillomavirus type 6: are these involved in malignant transition?
abstract: Human papillomavirus type 6 (HPV-6) was isolated from a tongue papilloma which subsequently progressed to an invasive carcinoma. Three biopsies were taken from the same patient at different intervals during the tumour development. The HPV-6 genome in all three biopsies contained a GT-rich 94 bp insertion at nucleotide 7350 in the upstream regulatory region (URR). In comparison to previously published HPV-6 DNA isolates, this insertion seems to be the most prevalent and constant modification, not present in the prototype HPV-6b, and allows an improved alignment with the sequence of the HPV-11 genome. The possible biological significance of these GT-rich clusterings at the beginning of the URR, present not only in these HPV-6 isolates but observed in all other 'genital' HPVs also, is discussed.
authors.affiliation: Deutsches Krebsforschungszentrum, Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kitasato
authors.forename: H
authors.initials: H
authors.lastname: Delius
authors.forename: H
authors.initials: H
authors.lastname: zur Hausen
authors.forename: K
authors.initials: K
authors.lastname: Sorger
authors.forename: F
authors.initials: F
authors.lastname: Rösl
authors.forename: E M
authors.initials: EM
authors.lastname: de Villiers
mesh_terms: D000368:Aged; D001483:Base Sequence; D001706:Biopsy; D002277:Carcinoma / Q000209:etiology* / Q000821:virology; D015321:Gene Rearrangement / Q000235:genetics; D016679:Genome, Viral; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013997:Time Factors; D014062:Tongue Neoplasms / Q000209:etiology* / Q000821:virology; D014412:Tumor Virus Infections / Q000235:genetics*