title: Balhimycin, a new glycopeptide antibiotic produced by Amycolatopsis sp. Y-86,21022. Taxonomy, production, isolation and biological activity.
abstract: A new glycopeptide antibiotic, balhimycin, has been isolated from the fermentation broth of a Amycolatopsis sp. Y-86,21022. Balhimycin belongs to the vancomycin class of glycopeptides and contains a dehydrovancosamine sugar. The biological activity of balhimycin has been compared extensively with that of vancomycin against methicillin resistant staphylococci and also against anaerobes. Balhimycin is marginally superior to vancomycin in its in vitro activity against anaerobes and in its bactericidal properties.
authors.affiliation: Microbiology Department, Hoechst India Limited, Mulund (W), Bombay.
authors.forename: S R
authors.initials: SR
authors.lastname: Nadkarni
authors.forename: M V
authors.initials: MV
authors.lastname: Patel
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: E K
authors.initials: EK
authors.lastname: Vijayakumar
authors.forename: K R
authors.initials: KR
authors.lastname: Desikan
authors.forename: J
authors.initials: J
authors.lastname: Blumbach
authors.forename: B N
authors.initials: BN
authors.lastname: Ganguli
authors.forename: M
authors.initials: M
authors.lastname: Limbert
mesh_terms: D039903:Actinobacteria / Q000145:classification / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001798:Blood Proteins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D011485:Protein Binding; D013210:Staphylococcus / Q000187:drug effects; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001798:Blood Proteins; C087127:balhimycin; D014640:Vancomycin