Distribution of lithium in the rat brain after a single administration known to elicit aversive effects.
In order to get insight into the brain areas involved in the initial unpleasant effects resulting from the administration of lithium (Li+), its distribution was mapped in the rat brain using the 6Li(n,alpha)3H nuclear reaction after a single injection of 6Li2SO4 at doses and latencies corresponding to the elicitation of such unpleasant effects. An improved method for visualization and measurement of local Li+ concentrations was used consisting in diffracting light along the tracks left by alpha particles in a dielectric detector. The distribution of Li+ was found less homogeneous than when Li+ was administered chronically. Periaqueductal and periventricular structures were the brain areas containing the highest concentrations of Li+.
Sandner
G
G
LNBC, Centre de Neurochimie, Strasbourg, France.
Di Scala
G
G
Oberling
P
P
Abbe
J C
JC
Stampfler
A
A
Sens
J C
JC
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001931:Brain Mapping; D002552:Cerebral Ventricles / Q000378:metabolism; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D010487:Periaqueductal Gray / Q000378:metabolism; D051381:Rats
D008094:Lithium