title: [Occupational exposure to chemical substances and congenital anomalies: state of the art].
abstract: Several thousands of compounds with a potential reproductive toxicity have been identified in animals, some of them are teratogens. In humans, only a small number of chemicals, administered as drugs, present in the diet, or in the occupational environment are recognized human teratogens. In parallel, about 60% of congenital anomalies have no identified cause and most probably some compounds present in the environment may contribute to certain anomalies. This paper presents a review of published epidemiological studies on the association between occupational exposures and congenital anomalies, focusing more particularly on some groups of compounds or some occupations such as: anaesthetic gases, laboratory work, solvents, pesticides and lead.
authors.affiliation: INSERM U. 170, Villejuif.
authors.forename: S
authors.initials: S
authors.lastname: Cordier
authors.forename: J
authors.initials: J
authors.lastname: Goujard
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000382:Agricultural Workers' Diseases / Q000139:chemically induced; D000777:Anesthetics / Q000633:toxicity; D000818:Animals; D005260:Female; D006282:Health Personnel; D006801:Humans; D007231:Infant, Newborn; D007855:Lead Poisoning / Q000150:complications; D008297:Male; D016273:Occupational Exposure; D010575:Pesticides / Q000633:toxicity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D012997:Solvents / Q000633:toxicity; D013723:Teratogens
chemical_list: D000777:Anesthetics; D010575:Pesticides; D012997:Solvents; D013723:Teratogens
vernacular_title: Expositions professionnelles à des substances chimiques et anomalies congénitales: état des connaissances.