Inadequate superoxide production by canine neutrophils in response to the combination of N-formyl-methionyl-leucyl-phenylalanine and cytochalasin B.
The formylated peptide, N-formyl-methionyl-leucyl-phenylalanine, at concentration of 0.22 microM, failed to stimulate canine neutrophils to produce adequate amounts of superoxide. Furthermore, addition of cytochalasin B did not augment superoxide generation appreciably.
Ing
T S
TS
Department of Medicine, Veterans Affairs Hospital, Hines, IL.
Yu
A W
AW
Patel
M
M
Gupta
V
V
Khan
M A
MA
Agrawal
A
A
Patel
P
P
D000328:Adult; D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology*; D004285:Dogs / Q000097:blood*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000097:blood*; D015054:Zymosan / Q000494:pharmacology
D013481:Superoxides; D003571:Cytochalasin B; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015054:Zymosan