title: Multiple comparisons in long-term toxicity studies.
abstract: Several multiple comparison procedures (MCPs) are discussed in relation to the specific formulation of type I and type II errors in toxicity studies and the typical one-way design control versus k treatment/dose groups. Examples for these MCPs are: the standard many-to-one MCP (Dunnett's procedure), sequential rejection modifications, closed testing procedures, many-to-one MCPs with an ordered alternative hypothesis, procedures based on the assumption of a mixing distribution of responders and nonresponders, and MCP's for multiple end points.
authors.affiliation: Department of Biostatistics, German Cancer Research Center, Heidelberg.
authors.forename: L
authors.initials: L
authors.lastname: Hothorn
mesh_terms: D015386:Hazardous Substances / Q000633:toxicity*; D015233:Models, Statistical; D012107:Research Design / Q000706:statistics & numerical data*; D013997:Time Factors
chemical_list: D015386:Hazardous Substances