Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.
Posner
G H
GH
Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218.
Oh
C H
CH
Wang
D
D
Gerena
L
L
Milhous
W K
WK
Meshnick
S R
SR
Asawamahasadka
W
W
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D037621:Artemisinins; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008745:Methylation; D015394:Molecular Structure; D010545:Peroxides; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000962:Antimalarials; D037621:Artemisinins; D006571:Heterocyclic Compounds; D010545:Peroxides; D012717:Sesquiterpenes; C087349:octahydro-9-hydroxyethyl-1-methoxy-3,4,4-trimethyl-1H-3,9a-peroxy-2-benzoxepin; C031327:artemisinin