title: Effects of an acidic, lactate-based peritoneal dialysis solution and its euhydric, bicarbonate-based counterpart on neutrophilic intracellular pH.
abstract: An exposure of human neutrophils to an acidic (pH 5.2), lactate-based incubation mixture containing a conventional, acidic, lactate-based peritoneal dialysis solution (PDS) resulted in the development of a prompt and substantial intracellular acidosis. A comparable exposure to a euhydric, bicarbonate-based incubation mixture containing a euhydric, bicarbonate-based PDS did not bring about similar changes in intracellular pH. The absence of an intracellular acidosis in the instance of the euhydric, bicarbonate-based PDS may be the reason why this solution is more biocompatible than its acidic, lactate-based counterpart.
authors.affiliation: Department of Medicine, University of California at Irvine.
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhou
authors.forename: A W
authors.initials: AW
authors.lastname: Yu
authors.forename: F Q
authors.initials: FQ
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Ryu
authors.forename: T S
authors.initials: TS
authors.lastname: Ing
authors.forename: N D
authors.initials: ND
authors.lastname: Vaziri
mesh_terms: D001639:Bicarbonates; D015314:Dialysis Solutions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007773:Lactates; D009504:Neutrophils / Q000378:metabolism*; D010530:Peritoneal Dialysis
chemical_list: D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates