Drug dosing in renal insufficiency.
Drug dosing in renal insufficiency needs to be individualized whenever possible to optimize therapeutic outcomes and to minimize toxicity. Although a number of published tables that provide dosing guidelines and nomograms exist to assist in dose modification, individualization of therapy should be based on pharmacokinetic principles whenever possible. The basis equations to estimate the pharmacokinetic parameters of clearance, volume of distribution, and half-life for intravenous drug administration of drugs with first-order kinetics are not difficult to understand and apply. Their use should be encouraged in patient care.
Talbert
R L
RL
College of Pharmacy, University of Texas at Austin.
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D004334:Drug Administration Schedule; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism*; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D017595:Renal Plasma Flow / Q000502:physiology
D004364:Pharmaceutical Preparations; D003404:Creatinine