title: Glucose oxidase electrodes: effect of hydrogen peroxide on enzyme activity?
abstract: This paper presents a simple procedure to assess the amount of hydrogen peroxide arising in amperometric glucose oxidase sensors. At an external glucose concentration of 30 mmol/l, which represents the linear range of calibration, a hydrogen peroxide concentration of approximately 0.18 mmol/l is generated. Taking into consideration that in medical applications the main range of interest would be within euglycaemia which is between 4 and 9 mmol/l, it is concluded that in the type of glucose electrode investigated, hydrogen peroxide produced during enzymatic glucose measurement does not appreciably damage the enzyme glucose oxidase.
authors.affiliation: Gerhardt Katsch Institute of Diabetes, University of Greifswald, Karlsburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: von Woedtke
authors.forename: U
authors.initials: U
authors.lastname: Fischer
authors.forename: P
authors.initials: P
authors.lastname: Abel
mesh_terms: D015374:Biosensing Techniques; D005949:Glucose Oxidase; D006861:Hydrogen Peroxide / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D006861:Hydrogen Peroxide; D005949:Glucose Oxidase