title: Interleukin-7, interleukin-8, soluble TNF receptor, and p53 protein levels are elevated in the serum of patients with Hodgkin's disease.
abstract: In a search for specific serum markers with prognostic impact, we evaluated the clinical significance of IL-4, IL-7, and IL-8 as well as TNF receptor levels and soluble p53 in the serum of patients with untreated Hodgkin's lymphoma (HD). No elevations were observed for IL-4, while IL-7 and IL-8 were elevated in 15/52 (29%) and 21/78 (27%) patients, respectively. Soluble TNF receptors were detected in 16/29 patients (55%), and were significantly elevated in 6 (21%). P53 was detected in 21/33 (64%) patients. While IL-7 levels, detectable sTNF receptors, and p53 were not correlated with other obvious parameters, elevated IL-8 levels were associated with the presence of B symptoms (p < 0.002) and occurred more often in the nodular sclerosis form than in other histological subtypes (p < 0.02). Further investigations that correlate these serum parameters with the situation at the cellular level of an involved tissue will help to elucidate the enigmatic biology of HD.
authors.affiliation: Medizinische Klinik und Poliklinik, Innere I, University of Saarland, Homburg, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Trümper
authors.forename: W
authors.initials: W
authors.lastname: Jung
authors.forename: G
authors.initials: G
authors.lastname: Dahl
authors.forename: V
authors.initials: V
authors.lastname: Diehl
authors.forename: A
authors.initials: A
authors.lastname: Gause
authors.forename: M
authors.initials: M
authors.lastname: Pfreundschuh
mesh_terms: D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D012995:Solubility; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
chemical_list: D015851:Interleukin-7; D016209:Interleukin-8; D018124:Receptors, Tumor Necrosis Factor; D016159:Tumor Suppressor Protein p53