title: Reflex pharyngeal dilator muscle activation by stimuli of negative airway pressure in awake man.
abstract: This paper summarizes evidence for reflex genioglossus muscle activation by stimuli of negative airway pressure in normal, awake human subjects. Stimuli of negative airway pressure (range -5 to -35 cm H2O) caused activation of the genioglossus muscle. The larger values of negative pressure gave larger responses. Response latencies (median = 34 milliseconds) were much faster than the time for voluntary muscle activation (median = 184 milliseconds), suggesting that the responses were reflex in origin. The reflex nature of the responses was confirmed by studies with local anesthetics. The trigeminal, superior laryngeal and the glossopharyngeal nerves all mediated a component of the responses observed from the upper airway.
authors.affiliation: Department of Medicine, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, U.K.
authors.forename: R L
authors.initials: RL
authors.lastname: Horner
authors.forename: J A
authors.initials: JA
authors.lastname: Innes
authors.forename: A
authors.initials: A
authors.lastname: Guz
mesh_terms: D000399:Air Pressure; D004576:Electromyography; D006801:Humans; D010609:Pharyngeal Muscles / Q000294:innervation*; D010614:Pharynx / Q000294:innervation / Q000502:physiology*; D012123:Pulmonary Ventilation; D012018:Reflex; D014851:Wakefulness