Stability of carboplatin in 5% glucose solution in glass, polyethylene and polypropylene containers.
The degradation of carboplatin (3.2 mg ml-1) in 5% glucose infusion solution at 25 degrees C and protected from light was investigated. The effects of the material of the container and temperature were also studied. Solutions were prepared in 5% glucose solution and stored in glass bottles, polyethylene (PE) and polypropylene (PP) containers at 40, 50 and 60 degrees C and at 25 degrees C +/- 1 degrees C. Samples were assayed by an HPLC method to determine the residual carboplatin concentration at each time of sampling. Carboplatin degradation followed pseudo-first-order kinetics and no dependence on the nature of the container was found. After 1 month at 25 degrees (+/- 1 degrees)C the change in carboplatin concentration was < 2% of the initial concentration in 5% glucose. These results are in agreement with those predicted by the application of the Arrhenius equation.
Prat
J
J
Unitat de Físico-Química, Facultat de Farmacia, Barcelona, Spain.
Pujol
M
M
Girona
V
V
Muñoz
M
M
Solé
L A
LA
D016190:Carboplatin / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D005898:Glass; D005947:Glucose / Q000737:chemistry; D007700:Kinetics; D011095:Polyethylenes; D011126:Polypropylenes; D013696:Temperature
D011095:Polyethylenes; D011126:Polypropylenes; D016190:Carboplatin; D005947:Glucose