title: Effects of 100% O2 exposure on hypoxic ventilatory response.
abstract: Comparison of the slope of progressive isocapnic hypoxia obtained with and without prior O2 exposure (termed + and -O2 runs, respectively) placed our subjects into two groups. Positive responders had a significantly lower slope in -O2 runs compared with similar runs in negative responders, but they also improved hypoxic ventilatory response (HVR) significantly after O2 exposure. Negative responders had a high -O2 slope that did not alter significantly after O2 exposure. We conclude that ambient air hypoxic depression is active in positive responders who are O2 sensitive.
authors.affiliation: Department of Physiology, School of Medicine, Chiba University, Japan.
authors.forename: M F
authors.initials: MF
authors.lastname: Chowdhury
authors.forename: A
authors.initials: A
authors.lastname: Masuda
authors.forename: W
authors.initials: W
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage / Q000009:adverse effects*; D016037:Single-Blind Method
chemical_list: D010100:Oxygen