Effect of PGE in multiple experimental models. IX: In vivo effects of PGE on immune response of leucocytes to wounds.
There have been conflicting results obtained when comparing the in vitro with in vivo effects of prostaglandin E (PGE) on immune function. The in vitro studies have demonstrated immune suppression with PGE administration while the in vivo studies demonstrated improved survival when utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizing multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week period of study. PGE also failed to alter the percentage of T-lymphocyte subset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminescence, or on metabolic function of lymphocytes. In conclusion, PGE does not appear to have immunosuppressive properties when studied using certain in vivo models.
Dong
Y L
YL
Shriners Burns Institute, Galveston Unit.
Herndon
D N
DN
Yan
T Z
TZ
Waymack
J P
JP
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D014947:Wounds and Injuries / Q000276:immunology* / Q000378:metabolism
D000596:Amino Acids; D011458:Prostaglandins E