title: Granuloma after augmentation of the eyelids with liquid silicone: an electron microscopic study.
abstract: Granuloma after liquid silicone augmentation of the upper eyelids was studied by light and electron microscopy and energy dispersive x-ray analysis. Light microscopy showed proliferation of collagen fibers and many phagocytic macrophages with vacuoles. Electron microscopy showed many vacuoles in phagocytic macrophages, fragmentary myofibrils, and proliferation of collagen fibers. Vacuoles in phagocytic macrophages contained silicone that was demonstrated by energy dispersive x-ray analysis. The present case suggests that liquid silicone injection in the eyelid can induce degeneration of the orbicularis oculi muscle in addition to granuloma formation.
authors.affiliation: Department of Ophthalmology, Nagasaki University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Amemiya
authors.forename: Y
authors.initials: Y
authors.lastname: Dake
mesh_terms: D000368:Aged; D004577:Electron Probe Microanalysis; D005141:Eyelid Diseases / Q000209:etiology* / Q000473:pathology; D005143:Eyelids / Q000601:surgery*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007267:Injections; D012828:Silicones / Q000009:adverse effects*; D013518:Surgery, Plastic
chemical_list: D012828:Silicones