title: [Suppression of Helicobacter pylori by local secretory immune response?].
abstract: 54 patients (22 females, 32 males, age 21-79, mean 45 years) referred for upper gastrointestinal endoscopy were investigated. Helicobacter pylori (HP) infection was determined using histology (H&E and Giemsa stain), rapid urease test (CLO) and serology (Cobas Core Anti-H. pylori EIA). Density of HP colonization was determined in gastric antral (3 biopsy specimens) and body mucosa (2 biopsy specimens) and semiquantitatively graded on a scale of 0 to 3. Gastric colonization was obtained by addition of the two scores. IgA anti-HP concentration was determined by ELISA using the same FPLC purified HP-antigen mixture as for serology. Gastric juice IgA anti-HP concentration in HP-positive patients (n = 40) was significantly higher than in HP-negative (n = 14) patients (38.3 +/- 4.6 vs. 5.4 +/- 1.2 relative units, p < 0.001). Comparison of HP-colonization density of gastric mucosa with gastric juice IgA anti-HP concentration of the 54 patients by binominal regression analysis yielded a correlation coefficient of 0.65 (p < 0.01). The biphasic course of the curve suggests a mutual relationship of HP-colonization density and IgA immune response. Increasing colonization densities seemed to induce increasing secretory immune responses. Half-maximal and higher immune responses, however, seemed to suppress further HP colonization in vivo without eradicating the infection.
authors.affiliation: Department für Innere Medizin, Universitätsspital Zürich.
authors.forename: H P
authors.initials: HP
authors.lastname: Wirth
authors.forename: R
authors.initials: R
authors.lastname: Flury
authors.forename: C
authors.initials: C
authors.lastname: Meyenberger
authors.forename: R
authors.initials: R
authors.lastname: Ammann
authors.forename: J
authors.initials: J
authors.lastname: Altorfer
mesh_terms: D000328:Adult; D000368:Aged; D001431:Bacteriological Techniques; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005750:Gastric Juice / Q000276:immunology; D005753:Gastric Mucosa / Q000382:microbiology; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007071:Immunoglobulin A, Secretory / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000382:microbiology
chemical_list: D007071:Immunoglobulin A, Secretory
vernacular_title: Suppression von Helicobacter pylori durch die lokale sekretorische Immunantwort?