title: Increased frequency of the transferrin C2 subtype in Alzheimer's disease.
abstract: Several genetic variants of transferrin can be separated by polyacrylamide gel isoelectric focusing. Studies by other workers have revealed that the genetic type Tf C2 has an increased frequency in certain malfunctions which are associated with the formation of free radicals, suggesting that the iron binding of Tf C2 promotes the formation of hydroxyl radicals. In our study population of 20 patients with Alzheimer's disease, 13 had the C2 genetic subtype. Since the frequency of C2 in the South African population is 0.136 (14%), this represents a significant increase (p < 0.005) in the appearance of this genetic subtype.
authors.affiliation: Department of Chemical Pathology, Tygerberg Hospital, South Africa.
authors.forename: S J
authors.initials: SJ
authors.lastname: van Rensburg
authors.forename: M E
authors.initials: ME
authors.lastname: Carstens
authors.forename: F C
authors.initials: FC
authors.lastname: Potocnik
authors.forename: A K
authors.initials: AK
authors.lastname: Aucamp
authors.forename: J J
authors.initials: JJ
authors.lastname: Taljaard
mesh_terms: D000535:Aluminum / Q000378:metabolism; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005609:Free Radicals / Q000378:metabolism; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007501:Iron / Q000378:metabolism; D007525:Isoelectric Focusing; D013019:South Africa; D014168:Transferrin / Q000032:analysis / Q000235:genetics / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D014168:Transferrin; D000535:Aluminum; D007501:Iron