title: [Psychotic reactions during administration of quinolones].
abstract: A 86-year-old woman became psychotic one day after starting treatment with 800 mg norfloxacin daily. Discontinuation and short-term treatment with haloperidol were followed by rapid disappearance of symptoms within two days. Since 1984, the Netherlands Centre for Monitoring of Adverse Reactions to Drugs received 19 similar reports of which 12 were attributed to norfloxacin, 3 to ofloxacin and 4 to pipemidic acid. The risk appears to be relatively high in the elderly, especially if they have fever, renal dysfunction and a psychiatric history. Lowering the doses may solve this problem provided the bacterial susceptibility is taken into account.
authors.affiliation: Reinier de Graaf Gasthuis, afd. Interne Geneeskunde, Delft.
authors.forename: E F
authors.initials: EF
authors.lastname: Salm
authors.forename: A C
authors.initials: AC
authors.lastname: Egberts
authors.forename: E
authors.initials: E
authors.lastname: Maartense
authors.forename: W
authors.initials: W
authors.lastname: Hart
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000890:Anti-Infective Agents; D006220:Haloperidol; D009643:Norfloxacin
vernacular_title: Psychotische reacties tijdens het gebruik van chinolonen.