title: IGF-II producing hepatic fibrosarcoma associated with hypoglycemia.
abstract: A 67-year-old male was admitted with the complaint of weakness at hunger early in the morning, when blood glucose was less than 40 mg/dl. The abdominal ultrasonogram and computerized tomogram demonstrated a huge tumor in the right liver lobe. Hypoglycemia disappeared after transcatheter arterial embolization. Then hepatic lobectomy was performed. The tumor was histologically shown to be a fibrosarcoma. Insulin-like growth factor-II was intensely stained in the Golgi area of the tumor cells, suggesting its role in the mechanism of hypoglycemia.
authors.affiliation: Second Department of Internal Medicine, Kobe University.
authors.forename: K
authors.initials: K
authors.lastname: Kotani
authors.forename: M
authors.initials: M
authors.lastname: Tsuji
authors.forename: A
authors.initials: A
authors.lastname: Oki
authors.forename: T
authors.initials: T
authors.lastname: Kashihara
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: F
authors.initials: F
authors.lastname: Kawakami
authors.forename: H
authors.initials: H
authors.lastname: Tako
authors.forename: G
authors.initials: G
authors.lastname: Okuno
authors.forename: N
authors.initials: N
authors.lastname: Hizuka
authors.forename: M
authors.initials: M
authors.lastname: Aiba
mesh_terms: D000368:Aged; D004621:Embolization, Therapeutic; D005354:Fibrosarcoma / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000628:therapy; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000628:therapy
chemical_list: D007335:Insulin-Like Growth Factor II