Lactational changes in the N-glycoloylneuraminic acid content of bovine milk gangliosides.
The N-glycoloylneuraminic acid (Neu5Gc) contents of milk and milk gangliosides from bovines were investigated during the different stages of lactation. The Neu5Gc content of milk is high in the colostrum (32% of the total sialic acid content of milk) and decreases thereafter until the end of the period considered (6% on day 30). When the Neu5Gc content of gangliosides was evaluated a similar profile to that of Neu5Gc in total sialic acids was found. Gangliosides from colostrum showed the highest Neu5Gc content (21-22% of the total sialic acid content of milk gangliosides). This content dropped towards the end of the period studied (8% on day 90). Our results indicate that a significant supply of Neu5Gc by the milk could be important for the newborn during the first days after parturition.
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Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de León, Spain.
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D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D003126:Colostrum / Q000737:chemistry / Q000378:metabolism; D005732:Gangliosides / Q000737:chemistry / Q000378:metabolism*; D007774:Lactation / Q000502:physiology*; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D009438:Neuraminic Acids / Q000378:metabolism*; D012794:Sialic Acids / Q000032:analysis
D005732:Gangliosides; D009438:Neuraminic Acids; D012794:Sialic Acids; C032592:N-glycolylneuraminic acid