[The selectivity of the action of muscarinic agonists in vivo].
The experiments to inhibit a tremor reaction induced by various cholinomimetics have established that DED50 of atropine and amedine is significantly indifferent when tremor is caused by pilocarpine, oxotremorine, and aceclidine while the activity of amedine is lower than that of atropine when ezerine, arecoline and galantamine are applied. The comparison of the findings with the data on the selectivity of the above M-cholinolytics leads to the conclusion that in in vivo experiments, the muscarinic agonists are able to show their selectivity against various subtypes of M-cholinoreceptors. The results of in vivo experiments are found to differ from the data on the in vitro selectivity of M-cholinomimetics in some cases.
Kosmachev
A B
AB
Kosmacheva
I M
IM
Iankhotova
M V
MV
Kuleshov
V I
VI
D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage; D010276:Parasympatholytics / Q000008:administration & dosage; D010277:Parasympathomimetics / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control
D008333:Mandelic Acids; D010276:Parasympatholytics; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic; C016215:amedin; D001285:Atropine
Izbiratel'nost' deĭstviia muskarinovykh agonistov in vivo.