Possible association between the hernia of Morgagni and trisomy 21.
Of the 5 liveborn infants with the hernia of Morgagni recorded in the California Birth Defects Monitoring Program, 3 had trisomy 21. This significant association (P < 10(-6)) between the hernia of Morgagni and trisomy 21 may reflect defective dorsoventral migration of rhabdomyoblasts from the paraxial myotomes, caused by increased cellular adhesiveness in trisomy 21.
Honoré
L H
LH
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
Torfs
C P
CP
Curry
C J
CJ
D002465:Cell Movement; D002891:Chromosomes, Human, Pair 21; D003964:Diaphragm / Q000196:embryology; D004314:Down Syndrome / Q000150:complications*; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000235:genetics*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn