title: Characterization of an Arabidopsis thaliana gene (TMKL1) encoding a putative transmembrane protein with an unusual kinase-like domain.
abstract: We have characterized a novel Arabidopsis gene, designated TMKL1 (for Transmembrane Kinase-Like). The encoded protein is predicted to contain an N-terminal signal peptide, an extracellular domain with seven imperfect leucine-rich repeats, a single hydrophobic transmembrane segment, and a kinase-like intracellular domain which lacks, however, several of the key conserved residues essential for catalytic activity. The TMKL1 protein thus represents a unique and functionally intriguing member of the family of plant proteins related to animal receptor kinases. Northern blot analysis indicates that the TMKL1 gene is transcriptionally active in a variety of organs, and is developmentally regulated during silique maturation. Its possible functions are discussed.
authors.affiliation: Institut des Sciences Végétales, Centre National de la Recherche Scientifique UPR 40, Gif-sur-Yvette, France.
authors.forename: C
authors.initials: C
authors.lastname: Valon
authors.forename: J
authors.initials: J
authors.lastname: Smalle
authors.forename: H M
authors.initials: HM
authors.lastname: Goodman
authors.forename: J
authors.initials: J
authors.lastname: Giraudat
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics*; D029681:Arabidopsis Proteins; D017343:Genes, Plant; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics; D021382:Protein Sorting Signals / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
chemical_list: D029681:Arabidopsis Proteins; D008565:Membrane Proteins; D010940:Plant Proteins; D021382:Protein Sorting Signals; D012333:RNA, Messenger; C083956:TMKL1 protein, Arabidopsis; D011494:Protein Kinases