Ambroxol inhibits endotoxin-induced lipid peroxidation in mice.
Administration of ambroxol (70 mg/kg ip) once a day for 3 days protected lung and heart lipids from lipopolysaccharide (LPS, 17 mg/kg)-induced oxidative stress in mice. Ambroxol as a lipid peroxidation inhibitor was almost as active as an equivalent dose of N-acetylcysteine (27.6 mg/kg), a well known antioxidant. The lung and heart levels of conjugated dienes in animals pretreated with ambroxol were 3.3- and 1.7-times lower (p < 0.05 and p < 0.01) than those observed in the control group which received only buffer and subsequently LPS. These results indicate that ambroxol can sufficiently inhibit the harmful process of lipid peroxidation in vivo.
Nowak
D
D
Department of Pneumonology and Allergology, Medical Academy, Lódź, Poland.
Pietras
T
T
Antczak
A
A
Król
M
M
Piasecka
G
G
D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants; D003553:Cystine / Q000031:analogs & derivatives / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000975:Antioxidants; D008070:Lipopolysaccharides; D000551:Ambroxol; D003553:Cystine; C030905:N-monoacetylcystine