title: v-Src-induced transformation is inhibited by okadaic acid.
abstract: The tumor promoter okadaic acid is a potent inhibitor of the serine/threonine protein phosphatases 1 and 2A. Addition of okadaic acid to v-Src-transformed BALB/c 3T3 cells reverted them to a flat morphology, increased fibronectin levels in the extracellular matrix, reduced saturation density, and inhibited the formation of colonies in soft agar. The ability of v-Src-transformed cells to proliferate in low serum was also inhibited by okadaic acid. These data implicate serine/threonine phosphatases in v-Src-induced transformation.
authors.affiliation: Institute for Biomolecular Structure and Function, Hunter College, City University of New York, New York 10021.
authors.forename: R W
authors.initials: RW
authors.lastname: Gupta
authors.forename: C K
authors.initials: CK
authors.lastname: Joseph
authors.forename: D A
authors.initials: DA
authors.lastname: Foster
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000235:genetics; D002472:Cell Transformation, Viral / Q000187:drug effects* / Q000235:genetics; D004988:Ethers, Cyclic / Q000494:pharmacology*; D016391:Genes, src; D051379:Mice; D008807:Mice, Inbred BALB C; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: D004988:Ethers, Cyclic; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases