Heredity, genes and osteoarthritis.
Human osteoarthritis (OA) is a heterogeneous and multifactorial disease with multiple pathogenetic mechanisms implicated in its development and progression. Despite its complex clinical expression, it appears that some forms of OA have a heritable component. This article briefly updates the reader on recent research that addresses the subject of heredity as one of significance in the etiology of OA.
Williams
C J
CJ
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Jimenez
S A
SA
D000818:Animals; D001483:Base Sequence; D002357:Cartilage Diseases / Q000235:genetics; D003094:Collagen / Q000235:genetics; D005109:Extracellular Matrix / Q000502:physiology; D005544:Forecasting; D005796:Genes; D015316:Genetic Therapy; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010003:Osteoarthritis / Q000145:classification / Q000235:genetics* / Q000628:therapy; D010375:Pedigree
D003094:Collagen