[The distribution of hematoporphyrin derivatives in the animal body].
The pharmacokinetic distribution of haematoporphyrin derivative (HPD) and synthetic oligomeric haematoporphyrin (OG) which showed various lipophilicity was studied in animal tumor and normal tissues. The accumulation of dyes in tissue and their tumor-seeking capacity depended on the degree of polymerization, lipophilicity, and ratio of dye components. The difference in the absolute concentrations of HPD and OG (6.9 and 16.1 micrograms per g tissue, respectively) in tumor after dye injection in an adequate concentration (10 mg/kg b. w.) indicates that synthetic OG is beneficial for tumor diagnosis and photodynamic therapy.
Seĭlanov
A S
AS
Pyzhik
V M
VM
Seĭlanova
Iu A
IuA
Mironov
A F
AF
Deriuzhenko
I V
IV
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D017323:Dihematoporphyrin Ether / Q000032:analysis / Q000493:pharmacokinetics; D017324:Hematoporphyrin Derivative / Q000032:analysis / Q000493:pharmacokinetics*; D009368:Neoplasm Transplantation; D051381:Rats; D012016:Reference Values; D012513:Sarcoma, Experimental / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D017324:Hematoporphyrin Derivative; D017323:Dihematoporphyrin Ether
Raspredelenie proizvodnykh gematoporfirina v organizme zhivotnykh.