Relationship between cytokines and leukotriene B4 in sepsis.
To clarify the relationship between cytokines and arachidonic acid metabolites, we measured tumor necrosis factor (TNF-alpha), interleukin 8 (IL-8), and leukotriene B4 (LTB4). The subjects consisted of 30 patients with sepsis. The results were compared between patients who died (Group A) and those who survived (Group B). All TNF-alpha, IL-8, and LTB4 levels were significantly higher in Group A than in Group B, reflecting the severity of the disease. The LTB4 levels were significantly correlated with the TNF-alpha level and the IL-8 level. These results suggest that inflammatory cytokines, excessively produced due to inflammatory reactions, stimulate as a mediator the release of arachidonic acid, increasing LTB4 production.
Nakae
H
H
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Endo
S
S
Inada
K
K
Takakuwa
T
T
Kasai
T
T
Yoshida
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D007975:Leukotriene B4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D007975:Leukotriene B4