title: New teleocidin-related metabolites, (-)-7-geranylindolactam V and blastmycetin F, from Streptoverticillium blastmyceticum.
abstract: Two new teleocidin-related metabolites, (-)-7-geranylindolactam-V [2] and blastmycetin F [3], were isolated from fermentation broths of the actinomycete Streptoverticillium blastmyceticum NA34-17, and their structures were determined by spectroscopic methods. Compound 2 bound strongly to phorbol ester receptors in a mouse epidermal particulate fraction, suggesting that it is a potent in vivo tumor promoter comparable to teleocidins A-1 [4] and B-4 [5].
authors.affiliation: Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Irie
authors.forename: S
authors.initials: S
authors.lastname: Kajiyama
authors.forename: S
authors.initials: S
authors.lastname: Okuno
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Koshimizu
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: A
authors.initials: A
authors.lastname: Iwashima
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002273:Carcinogens / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D007769:Lactams / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013306:Streptomycetaceae / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000493:pharmacokinetics
chemical_list: D002273:Carcinogens; D007211:Indoles; D007769:Lactams; D010743:Phospholipids; C087534:7-geranylindolactam V; C087535:blastmycetin F; D013755:Tetradecanoylphorbol Acetate