title: Protein tyrosine phosphatases: characterization of extracellular and intracellular domains.
abstract: Protein tyrosine phosphatases (PTPs) play an important role in the regulation of cell growth and differentiation. With over 30 PTPs identified, the specific functions of these enzymes are now being addressed. The identification of extracellular domain receptor-like PTP interactions and the characterization of intracellular PTP 'targeting' domains represent recent efforts in this pursuit.
authors.affiliation: Department of Biological Chemistry, Medical School, Walther Cancer Institute, University of Michigan, Ann Arbor 48109-0606.
authors.forename: R J
authors.initials: RJ
authors.lastname: Mourey
authors.forename: J E
authors.initials: JE
authors.lastname: Dixon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002256:Carbonic Anhydrases / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology; D004721:Endoplasmic Reticulum / Q000201:enzymology; D005110:Extracellular Space / Q000201:enzymology; D006801:Humans; D007424:Intracellular Fluid / Q000201:enzymology; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D015815:Cell Adhesion Molecules; D017493:Leukocyte Common Antigens; D017027:Protein Tyrosine Phosphatases; D002256:Carbonic Anhydrases