Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.
The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differentially affect the test cell lines suggesting that some compounds, such as 1,3-dinitropyrene, are activated by cytochrome P4501A1, others, such as 1,6-dinitropyrene, by reductase(s) and acetyltransferase. No such cell specific responses were seen for 13 monocyclic nitroarenes tested. This group of chemicals apparently is activated by an enzyme(s) other than the polycyclic nitroarenes tested.
Perchermeier
M M
MM
Institute of Toxicology, GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany.
Kiefer
F
F
Wiebel
F J
FJ
D000818:Animals; D001711:Biotransformation; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004140:Dinitrophenols / Q000493:pharmacokinetics / Q000633:toxicity; D004353:Drug Evaluation, Preclinical / Q000379:methods; D051379:Mice; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity; D009574:Nitro Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D009578:Nitrobenzenes / Q000493:pharmacokinetics / Q000633:toxicity; D009596:Nitrophenols / Q000493:pharmacokinetics / Q000633:toxicity; D011083:Polycyclic Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D011721:Pyrenes / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D012680:Sensitivity and Specificity; D014050:Toluene / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000633:toxicity
D004140:Dinitrophenols; D009153:Mutagens; D009574:Nitro Compounds; D009578:Nitrobenzenes; D009596:Nitrophenols; D011083:Polycyclic Compounds; D011721:Pyrenes; D014050:Toluene; C033309:1,6-dinitropyrene; C037413:1,3-dinitropyrene