title: Surgical revascularization after fibrinolysis in acute myocardial infarction. Long-term follow-up.
abstract: One hundred twenty-eight patients with myocardial infarction who underwent operation for myocardial revascularization and 147 patients who received medical therapy were followed up for up to 6 years: all patients had received treatment with intravenous streptokinase. In the surgical group, 91.5% of the patients had the region related to the infarction revascularized, and in 82.8% of them the mammary artery was used. Statistically significant differences were not detected between the groups according to infarct size, clinical features, and left ventricular ejection fraction. However, there was a higher risk in the surgical group, as compared with that in the medical group, in terms of anatomic characteristics: 99.2% versus 77.1% of the patients showed more than 70% residual obstruction at the "culprit" coronary artery (p < 0.001, 95% confidence interval 14.1% to 30.1%) and 76.8% versus 40.7% showed multivessel coronary disease (p < 0.001, 95% confidence interval 23.7% to 48.5%). In-hospital survival was 95.3% in the surgical group and 89.1% in the medical group (p = 0.096, 95% confidence interval -0.2% to 12.6%). Significantly higher survivals were obtained for the surgical group both during the first (93% +/- 2.3% versus 80.3% +/- 3.3%, p = 0.005) and the sixth (86.4% +/- 3.4% versus 68.4% +/- 4.3%, p = 0.003) year of follow-up. Statistically significant differences were also obtained when in-hospital deaths were excluded. A Cox regression model with 13 variables showed that only age (p = 0.0422) and medical treatment (p = 0.0194) correlated independently with mortality. It is concluded that in this nonrandomized study, operation led to a significantly higher survival both on a medium- and long-term basis, when compared with that obtained for patients receiving medical therapy.
authors.affiliation: Instituto de Moléstias Cardiovasculares, São José do Rio Preto, Brazil.
authors.forename: J C
authors.initials: JC
authors.lastname: Nicolau
authors.forename: R V
authors.initials: RV
authors.lastname: Ardito
authors.forename: S A
authors.initials: SA
authors.lastname: Garzon
authors.forename: M A
authors.initials: MA
authors.lastname: Pinto
authors.forename: P R
authors.initials: PR
authors.lastname: Nogueira
authors.forename: A M
authors.initials: AM
authors.lastname: Lorga
authors.forename: J L
authors.initials: JL
authors.lastname: Jacob
mesh_terms: D000206:Actuarial Analysis; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D009204:Myocardial Revascularization; D011446:Prospective Studies; D012044:Regression Analysis; D013300:Streptokinase / Q000627:therapeutic use*; D016019:Survival Analysis; D015912:Thrombolytic Therapy; D016896:Treatment Outcome
chemical_list: D013300:Streptokinase