title: Unbalanced 1;7 translocation in myelodysplastic syndrome following treatment of acute myeloblastic leukemia with an 8;21 translocation.
abstract: The chromosome der(1;7)(q10;p10) consists of the short arm of chromosome 7 and the long arm of chromosome 1, and is a common abnormality in treatment-related leukemia and myelodysplastic syndrome. Here we describe a 39-year-old Japanese man with acute myeloblastic leukemia (FAB-M2) exhibiting t(8;21)(q22;q22). He entered complete remission after induction therapy, and intensification therapy including alkylating agents was subsequently continued for 3 years. The patient then developed pancytopenia; bone marrow aspiration revealed myelodysplastic syndrome exhibiting the der (1;7) chromosome. To our knowledge, this is the first reported case of such an abnormality in myelodysplastic syndrome secondary to acute myeloblastic leukemia with the 8;21 translocation.
authors.affiliation: First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hamamoto
authors.forename: A
authors.initials: A
authors.lastname: Hashimoto-Ninomiya
authors.forename: Y
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Fujitake
authors.forename: K
authors.initials: K
authors.lastname: Yasunaga
authors.forename: S
authors.initials: S
authors.lastname: Horiike
mesh_terms: D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000139:chemically induced / Q000235:genetics*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002878:Chromosomes, Human, Pair 1; D002891:Chromosomes, Human, Pair 21; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic