Repeated doses of suxamethonium in the myasthenic patient.
The neuromuscular block of successive doses of suxamethonium 100 mg, monitored by electromyography, was investigated in a myasthenic patient (class IIB), undergoing thymectomy. The results suggest that successive doses of suxamethonium in the myasthenic patient are followed by a progressive prolongation of the neuromuscular block. This may be attributed to rapid desensitisation of the myasthenic endplate receptors and the rapid development of phase II block, as evidence by a progressive decrease of the T4/T1 ratio.
Baraka
A
A
Department of Anesthesiology, American University of Beirut, Lebanon.
Baroody
M
M
Yazbeck
V
V
D000328:Adult; D004334:Drug Administration Schedule; D004576:Electromyography; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D013390:Succinylcholine / Q000008:administration & dosage* / Q000494:pharmacology; D013934:Thymectomy; D013997:Time Factors
D013390:Succinylcholine