Genetic polymorphisms in HLA-A, -B, -C and -DR antigens in Japanese patients with palmoplantar pustulosis.
Genetic polymorphisms in HLA-A, -B, -C and -DR antigens were investigated in 78 unrelated Japanese patients with palmoplantar pustulosis (PPP) and compared with a total of 472 normal persons. Only HLA-DR9 showed a significantly increased frequency among all HLA antigens investigated (chi 2 = 11.57, p < 0.001). It is suggested that major histocompatibility complex class II antigens including HLA-DR antigen may determine the susceptibility to PPP and PPP may be a distinct disease entity from psoriasis.
Torii
H
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Nakagawa
H
H
Ishibashi
Y
Y
Tokunaga
K
K
Juji
T
T
D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics*; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics*; D015793:HLA-B7 Antigen / Q000032:analysis / Q000235:genetics; D015236:HLA-C Antigens / Q000032:analysis / Q000235:genetics*; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*
D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; D015235:HLA-B Antigens; C080311:HLA-B46 antigen; D015793:HLA-B7 Antigen; D015236:HLA-C Antigens; C069021:HLA-Cw11 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C038988:HLA-DR9 antigen