Erythrocyte P antigen: cellular receptor for B19 parvovirus.
The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parvoviruses in gene therapy.
Brown
K E
KE
Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892.
Anderson
S M
SM
Young
N S
NS
D000911:Antibodies, Monoclonal; D002213:Capsid / Q000378:metabolism; D002240:Carbohydrate Sequence; D003588:Cytopathogenic Effect, Viral; D004910:Erythrocyte Membrane / Q000276:immunology / Q000382:microbiology*; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000382:microbiology; D005915:Globosides / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D006384:Hemagglutination; D006801:Humans; D008969:Molecular Sequence Data; D010127:P Blood-Group System / Q000276:immunology / Q000378:metabolism*; D016732:Parvovirus B19, Human / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D010641:Phenotype; D011991:Receptors, Virus / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D005915:Globosides; D010127:P Blood-Group System; D011991:Receptors, Virus