Relative contribution of type I and II corticosterone receptors in VMH lesion-induced obesity and hyperinsulinemia.
Ventromedial hypothalamic (VMH) lesion-induced obesity is accompanied by hyperinsulinemia and hyperphagia, which are dependent upon corticosterone (Cort) for their expression. Whether Cort exerts these actions through its stimulation of type I or II Cort receptor populations is unknown. Therefore, food intake and weight gain were measured in obese adrenalectomized VMH-lesioned rats given continuous infusion of various doses of either a type I-receptor agonist (aldosterone), a type II-receptor agonist (RU-28362), or several combination doses. Similarly, the receptor population responsible for lesion-induced hyperinsulinemia was identified. Type II receptor stimulation restored the hyperphagia, weight gain, and hyperinsulinemia of adrenalectomized VMH-lesioned animals, while type I receptor stimulation blocked their weight loss.
Thomas
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TL
Department of Psychology, University of Oklahoma, Norman 73019.
Devenport
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LD
Stith
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RD
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006946:Hyperinsulinism / Q000503:physiopathology*; D006963:Hyperphagia / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011987:Receptors, Steroid / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology*; D015430:Weight Gain
D000732:Androstanols; D007328:Insulin; D011987:Receptors, Steroid; C024357:corticosterone receptor; D000450:Aldosterone; C049154:11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one