title: Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
abstract: Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early-onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid precursor-like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late-onset FAD. Here we report the isolation of the human APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain and throughout the body. Like APP, APLP2 contains a cytoplasmic domain predicted to couple with the GTP-binding protein G(o) indicating that it may be an additional cell surface activator of this G protein.
authors.affiliation: Laboratory of Genetics and Aging, Massachusetts General Hospital, Charlestown 02129.
authors.forename: W
authors.initials: W
authors.lastname: Wasco
authors.forename: S
authors.initials: S
authors.lastname: Gurubhagavatula
authors.forename: M D
authors.initials: MD
authors.lastname: Paradis
authors.forename: D M
authors.initials: DM
authors.lastname: Romano
authors.forename: S S
authors.initials: SS
authors.lastname: Sisodia
authors.forename: B T
authors.initials: BT
authors.lastname: Hyman
authors.forename: R L
authors.initials: RL
authors.lastname: Neve
authors.forename: R E
authors.initials: RE
authors.lastname: Tanzi
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001923:Brain Chemistry; D019204:GTP-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009928:Organ Specificity; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: C489697:APLP1 protein, human; C084104:APLP2 protein, human; D016564:Amyloid beta-Protein Precursor; D009419:Nerve Tissue Proteins; D019204:GTP-Binding Proteins