Effect of the sulfonylurea glyburide on superoxide dismutase activity in alloxan-induced diabetic rat hepatocytes.
In the present study we administrated glyburide (glibenclamide) to type 2 (NIDDM) diabetic rats and determined the effect of such treatment on liver superoxide dismutase (SOD) activity. Hepatic SOD activity was significantly reduced in diabetic animals. Glyburide treatment of diabetic rats for 4 weeks corrected the changes observed in diabetic liver. In addition, blood glucose levels of untreated diabetic rats decreased following glyburide treatment. Administration of glyburide to diabetic rats reversed the diabetes-induced changes, suggesting that glyburide may directly increase liver SOD enzyme activity.
Altan
N
N
Department of Biochemistry, Faculty of Medicine, University of Gazi, Ankara, Turkey.
Ongun
C O
CO
Hasanoğlu
E
E
Engin
A
A
Tuncer
C
C
Sindel
S
S
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D012016:Reference Values; D013482:Superoxide Dismutase / Q000378:metabolism*
D001786:Blood Glucose; D013482:Superoxide Dismutase; D005905:Glyburide