title: Huntington's disease in five siblings.
abstract: Huntington's disease is an autosomal dominant neurodegenerative condition which is rare in Singapore. Five siblings with progressive chorea and dementia were treated at the Singapore General Hospital and followed up over a seven-year period. Family history revealed five deceased affected individuals, two living affected siblings and more than 35 "at risk" offspring spanning another two generations each with about a 50% probability of carrying the Huntington's disease gene. We believe this is the largest kindred with Huntington's disease in Singapore.
authors.affiliation: Neurology Unit, Singapore General Hospital.
authors.forename: M C
authors.initials: MC
authors.lastname: Wong
authors.forename: I S
authors.initials: IS
authors.lastname: Ng
authors.forename: S H
authors.initials: SH
authors.lastname: Lim
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010375:Pedigree; D012846:Singapore