In vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis.
We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This result correlated with the observed therapeutic efficacies of the quinolones.
Gollapudi
S V
SV
Department of Internal Medicine, Charles R. Drew University of Medicine and Science, UCLA School of Medicine 90059.
Chuah
S K
SK
Harvey
T
T
Thadepalli
H D
HD
Thadepalli
H
H
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001441:Bacteroides fragilis; D016516:CD4-CD8 Ratio / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology*; D005260:Female; D024841:Fluoroquinolones; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*; D013154:Spleen / Q000033:anatomy & histology / Q000187:drug effects; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D014409:Tumor Necrosis Factor-alpha; D002939:Ciprofloxacin; C060328:rufloxacin