Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae.
An epidemic of nosocomial ceftazidime-resistant Klebsiella pneumoniae was correlated with production of a ceftazidime-hydrolyzing enzyme with an isoelectric point of 5.6 (BMH-1). BMH-1 was encoded on a large transferable plasmid conferring multiple antibiotic resistance. The gene that encodes BMH-1 was identical to the gene that encodes the TEM-26 extended-spectrum beta-lactamase.
Urban
C
C
Department of Medicine, New York Hospital Medical Center of Queens, Flushing 11355.
Meyer
K S
KS
Mariano
N
N
Rahal
J J
JJ
Flamm
R
R
Rasmussen
B A
BA
Bush
K
K
D001483:Base Sequence; D002442:Ceftazidime / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial; D006801:Humans; D007526:Isoelectric Point; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology*; D008969:Molecular Sequence Data; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D004269:DNA, Bacterial; D002442:Ceftazidime; C087312:beta-lactamase TEM-26; D001618:beta-Lactamases