title: NS-3, a TRH analog, reverses repeated ECS-induced deficits in water maze performance in the rat.
abstract: Rats given five consecutive daily electroconvulsive shock (ECS) treatments and trained to run in the Morris water maze, starting three days posttreatment, showed deficits in learning and memory functions. Treatment before each training session with the thyrotropin-releasing hormone (TRH) analog NS-3 [(CG-3703), (3R),(6R)-6-methyl-5-oxo-3-thiomorphorinyl-l-histidyl-l-prolinamid e tetrahydrate] reversed these behavioral deficits. The possible use of TRH and its analogs as therapeutic treatment for the cognitive dysfunctions resulting from electroconvulsive shock treatment for depression and the possible involvement of central cholinergic systems in the cognitive dysfunctions are discussed.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98195.
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: H
authors.initials: H
authors.lastname: Lai
authors.forename: Y
authors.initials: Y
authors.lastname: Ukai
authors.forename: M H
authors.initials: MH
authors.lastname: Mirolo
mesh_terms: D000818:Animals; D004597:Electroshock; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C031926:montirelin; D013973:Thyrotropin-Releasing Hormone