title: LCH-I: a randomized trial of etoposide vs. vinblastine in disseminated Langerhans cell histiocytosis. The Histiocyte Society.
abstract: An international randomized trial in Langerhans cell histiocytosis (LCH) has been initiated by the Histiocyte Society. This report reviews the rationale, design, and progress of LCH-I, which compares etoposide (VP-16) and vinblastine in the treatment of disseminated LCH. Data on the risk of etoposide-associated (therapy-induced) malignancy, in the setting of histiocytosis, are reviewed. The available evidence leads to the recommendation that the study of etoposide in LCH should be continued.
authors.affiliation: Center for Cancer and Transplantation Biology, Children's Research Institute, Washington, DC 20010-2970.
authors.forename: S
authors.initials: S
authors.lastname: Ladisch
authors.forename: H
authors.initials: H
authors.lastname: Gadner
authors.forename: M
authors.initials: M
authors.lastname: Aricò
authors.forename: V
authors.initials: V
authors.lastname: Broadbent
authors.forename: N
authors.initials: N
authors.lastname: Grois
authors.forename: A
authors.initials: A
authors.lastname: Jacobson
authors.forename: D
authors.initials: D
authors.lastname: Komp
authors.forename: H S
authors.initials: HS
authors.lastname: Nicholson
mesh_terms: D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy*; D006801:Humans; D007938:Leukemia / Q000139:chemically induced; D008775:Methylprednisolone / Q000008:administration & dosage; D014747:Vinblastine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014747:Vinblastine; D005047:Etoposide; D008775:Methylprednisolone