title: Immune surveillance and sunlight-induced skin cancer.
abstract: Immune surveillance poses the existence of a recirculating pool of lymphocytes that migrate randomly through somatic tissues. Upon recognition of neoantigens on malignantly transformed cells, lymphocytes proceed to attack and destroy degenerate cells before a tumor emerges. Here, J. Wayne Streilein and colleagues review the effects of ultraviolet B irradiation on the induction of cutaneous immunity in the skin of mice and humans. Furthermore, they discuss the possibility of a genetic predisposition to skin cancer, mediated by a defect in the normal process by which contact hypersensitivity, and therefore immunogenicity, is elicited.
authors.affiliation: Schepens Eye Research Institute, Boston, MA 02114.
authors.forename: J W
authors.initials: JW
authors.lastname: Streilein
authors.forename: J R
authors.initials: JR
authors.lastname: Taylor
authors.forename: V
authors.initials: V
authors.lastname: Vincek
authors.forename: I
authors.initials: I
authors.lastname: Kurimoto
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: C
authors.initials: C
authors.lastname: Tie
authors.forename: C
authors.initials: C
authors.lastname: Golomb
mesh_terms: D000818:Animals; D006801:Humans; D007157:Immunologic Surveillance / Q000528:radiation effects*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D012867:Skin / Q000276:immunology* / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology*; D013472:Sunlight / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects