[7-fluoro-4-chromone-3-sulfur compounds].
The novel 7-fluoro-4-chromone-3-sulfur compounds 5-12 were synthesized from the sulfinic acid 4, which can be obtained from the enaminone 3 and thionyl chloride. Especially the Flosequinane-like sulfoxide 12 was prepared and the vasodilating activity was evaluated in isolated ring segments of rat aorta.
Löwe
W
W
Institut für Pharmazie, Freien Universität Berlin.
Elz
S
S
Reiser
H
H
Schott
S
S
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D002867:Chromones; D014665:Vasodilator Agents
7-Fluor-4-chromon-3-Schwefel-Verbindungen.