title: Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors.
abstract: The relation of habitual diet and cardiorespiratory fitness to plasma fibrinogen concentration, Factor VII activity (F VIIc), Factor X activity (F X), tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) concentrations, anti-thrombin III (AT III) and apolipoprotein(a) (Apo[a]) was analyzed in 111 normolipidemic men aged 51-53 years. Diet was evaluated by seven day food records. Maximal oxygen consumption and aerobic threshold were determined in maximal bicycle ergospirometry test based on breath-by-breath analysis of expired respiratory gas. Plasma fibrinogen was measured by thrombin method, F VIIc by one-stage coagulation method, AT III and F X colorimetrically, t-PA and PAI-1 antigens by ELISA and Apo(a) concentration radioimmunologically. Carbohydrate intake was negatively (r = -0.31, p < 0.001; r = -0.24, p < 0.01; r = -0.36, p < 0.001) and fat intake positively (r = 0.24, p < 0.01; r = 0.29, p < 0.001; r = 0.32, p < 0.001) related to F X, PAI-1, and t-PA, respectively. Aerobic threshold correlated negatively with fibrinogen (r = -0.33, p < 0.001) and F X (r = -0.30, p < 0.001). Fasting insulin was the strongest determinant for PAI-1 (r = 0.55, p < 0.001) and a significant positive correlate to F VIIc (r = 0.30, p < 0.001), F X (r = 0.28, p < 0.01) and t-PA (r = 0.47, p < 0.001). These data emphasize the importance that carbohydrate rich diet and cardiorespiratory fitness may have against thrombogenesis.
authors.affiliation: Kuopio Research Institute of Exercise Medicine, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Rankinen
authors.forename: R
authors.initials: R
authors.lastname: Rauramaa
authors.forename: S
authors.initials: S
authors.lastname: Väisänen
authors.forename: I M
authors.initials: IM
authors.lastname: Penttilä
authors.forename: M
authors.initials: M
authors.lastname: Uusitupa
mesh_terms: D000332:Aerobiosis / Q000502:physiology; D000990:Antithrombin III / Q000378:metabolism; D001053:Apolipoproteins / Q000378:metabolism; D053241:Apoprotein(a); D001777:Blood Coagulation / Q000502:physiology*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D017270:Lipoprotein(a); D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D001053:Apolipoproteins; D004040:Dietary Carbohydrates; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; D000990:Antithrombin III; D005167:Factor VII; D005170:Factor X; D005340:Fibrinogen; D053241:Apoprotein(a); D010959:Tissue Plasminogen Activator