Age-related changes in peripheral benzodiazepine receptors of human platelets.
Using 3H-PK 11195 as radioligand, the number and affinity of peripheral benzodiazepine receptors in platelets of 15 elderly healthy subjects were compared to those of 15 young subjects. The results showed that the dissociation constant (Kd) was significantly higher in the elderly than in the young subjects, while the density of binding sites did not differ. These findings suggest that the age-related changes in peripheral benzodiazepine receptors may be coupled with secondary changes in their hypothesized functions.
Marazziti
D
D
Institute of Psychiatry, University of Pisa, Italy.
Pancioli-Guadagnucci
M L
ML
Rotondo
A
A
Giannaccini
G
G
Martini
C
C
Lucacchini
A
A
Cassano
G B
GB
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D001665:Binding Sites / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011963:Receptors, GABA-A / Q000502:physiology*
D011963:Receptors, GABA-A