[Potentiation of cytotoxicity of electromagnetic shock waves by suramin, "in vitro" study].
The objective of this experimental study is to assess the inhibition of tumoral cells growth induced by electromagnetic shockwaves at different energy levels in PC-3, the human prostate adenocarcinoma cell line. Also, an assessment is made of the inhibition of cell growth caused by adding Suramin to the growth medium and the enhancement of cytotoxicity when associated to that produced by electromagnetic shockwaves. Cells viability is determined by life staining exclusion methods and nucleoside incorporation. Cytotoxic action of electromagnetical shockwaves in the PC-3 cell line is dose dependent (p < 0001). Suramin significantly inhibits cell viability (p < 0001). The association of both therapeutical approaches enhances significantly their individual cytotoxicities (p < 0001).
Rosell
D
D
Servicio de Urología, Clínica Universitaria de Navarra, Pamplona.
Robles
J E
JE
Aguera
L
L
Abad
J I
JI
Rodríguez-Rubio
F I
FI
Zudaire
J J
JJ
Berian
J M
JM
D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy*; D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects*; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy*; D011827:Radiation; D013498:Suramin / Q000494:pharmacology* / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D013498:Suramin
Potenciación de la citotoxicidad de las ondas de choque electromagnéticas por la Suramina, estudio "in vitro".