The treatment of autoimmune disease in (NZB/NZW)F1 mice with syngeneic photomodulated splenocytes.
(NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high-titre IgG anti-dsDNA antibodies. The function of the autoreactive T cells in vivo, however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoantibody-related autoimmune diseases.
Lin
R H
RH
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, ROC.
Wang
L F
LF
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D001402:B-Lymphocytes; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D017893:Photopheresis; D013154:Spleen / Q000166:cytology
D000974:Antibodies, Antinuclear