title: [Relationship between rheumatic disease and mitral valve prolapse: an etiopathogenetic connection or the result of a semiologic confusion?].
abstract: The term mitral valve prolapse is used to describe either one of the pathophysiological mechanisms of mitral regurgitation or a distinct biological condition with a defined inherited basis, with or without mitral incompetence. In the former case, association with rheumatic fever is implied by the definition itself; in the latter it's questionable (rheumatic fever could act as an environmental factor in the expression of a genetically determined mitral valve prolapse). Three hundred and twenty patients with mitral valve prolapse, diagnosed as a primary one, were studied in order to assess the prevalence of a well-documented history of rheumatic fever: this resulted higher versus a control population (5.6% vs 0.9%-p < 0.01). The retrospective nature of the study does not allow a definite conclusion. Familial as well as long-term follow-up studies are necessary to better define the association between rheumatic fever and mitral valve prolapse; a potentially different prognosis, mainly accounting to the development of a clinically relevant mitral regurgitation in patients with mitral valve prolapse and previous rheumatic fever, has to be searched.
authors.affiliation: Cardiologia San Luca, Osp. Careggi, USL 10/D Firenze.
authors.forename: A
authors.initials: A
authors.lastname: Zuppiroli
authors.forename: S
authors.initials: S
authors.lastname: Favilli
authors.forename: F
authors.initials: F
authors.lastname: Mori
authors.forename: A
authors.initials: A
authors.lastname: Dolara
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology; D008945:Mitral Valve Prolapse / Q000175:diagnosis / Q000209:etiology*; D011379:Prognosis; D012189:Retrospective Studies; D012213:Rheumatic Fever / Q000150:complications* / Q000175:diagnosis
vernacular_title: Il rapporto tra malattia reumatica e prolasso della valvola mitrale: nesso etiopatogenetico o frutto di una confusa semiologia?