Subacute sensory neuronopathy in small cell cancer of the lung. Immunocytochemical study of 2 cases.
Two cases of subacute sensory neuronopathy (SSN) associated with small cell lung cancer are reported. In both cases motor disability, attributed to motor neuropathy and neuronopathy, respectively, accompanied SSN. Immunohistochemical studies performed provide further data suggesting the involvement of humoral antibodies and the participation of protease inhibitors in the pathogenesis of SSN.
Kida
E
E
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Barcikowska
M
M
Joachimowicz-Jaskowiak
E
E
Michalska
T
T
Siekierzynska
A
A
Walasik
A
A
Roszkowski
K
K
Figura-Chojak
E
E
D001323:Autoantibodies / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology*; D003176:Complement C3 / Q000032:analysis; D005293:Ferritins / Q000032:analysis; D005727:Ganglia, Spinal / Q000276:immunology / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology / Q000473:pathology; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D009468:Neuromuscular Diseases / Q000276:immunology / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000276:immunology / Q000473:pathology*; D012678:Sensation Disorders / Q000276:immunology / Q000473:pathology*; D013116:Spinal Cord / Q000276:immunology / Q000473:pathology*; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
D001323:Autoantibodies; D003176:Complement C3; D005904:Glial Fibrillary Acidic Protein; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000514:alpha 1-Antichymotrypsin; D005293:Ferritins