title: Cerebral aspergillosis in immunologically competent patients.
abstract: Aspergillosis of the central nervous system is a rare disease, especially if the patient's immune system is not compromised. The authors report three cases of cerebral aspergillosis in the immunocompetent state: a rhinocerebral form in a diabetic patient, a direct extension from chronic Aspergillus otitis media, and a postoperative Aspergillus brain abscess after brain tumor surgery. In spite of the poor prognosis of cerebral aspergillosis, two of the patients survived. The pathogenesis, predisposing factors, radiologic findings including magnetic resonance image, and the outcome are presented. The pertinent literature of cerebral aspergillosis is also reviewed.
authors.affiliation: Department of Neurosurgery, Seoul National University College of Medicine, South Korea.
authors.forename: D G
authors.initials: DG
authors.lastname: Kim
authors.forename: S C
authors.initials: SC
authors.lastname: Hong
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: J G
authors.initials: JG
authors.lastname: Chi
authors.forename: M H
authors.initials: MH
authors.lastname: Han
authors.forename: K S
authors.initials: KS
authors.lastname: Choi
authors.forename: D H
authors.initials: DH
authors.lastname: Han
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D001922:Brain Abscess / Q000000981:diagnostic imaging / Q000382:microbiology; D001927:Brain Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007121:Immunocompetence; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000601:surgery; D008579:Meningioma / Q000601:surgery; D008875:Middle Aged; D009668:Nose Diseases / Q000276:immunology / Q000382:microbiology; D010033:Otitis Media / Q000382:microbiology; D011183:Postoperative Complications; D014057:Tomography, X-Ray Computed