[The effect of fenibut on the ultrastructure of the brain mitochondria in traumatic edema and swelling].
Rat experiments using electron microscopy have established that profound destructive changes occur in the mitochondria in the intra- and perifocal traumatic area in dynamics of traumatic edema-swelling. With phenibut, 50 mg/kg, there is an increase in the number of mitochondria in the brain tissue of the perifocal area, their destructive changes are less pronounced. It is assumed that the positive effect of phenibut on brain bioenergetic processes in the posttraumatic period is associated with the changes.
Novikov
V E
VE
Naperstnikov
V V
VV
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid
Vliianie fenibuta na ul'trastrukturu mitokhondriĭ mozga pri travmaticheskom oteke-nabukhanii.