Interaction between HMG proteins (1 + 2) and the negative regulatory region 1 (NCR1) in the 5'-flanking sequence of the human beta-globin gene.
The pattern of high mobility group proteins 1 and 2 (HMG1,2) interaction with the 5'-flanking sequence of the human beta-globin gene has been analyzed by scanning tunnelling microscopy (STM). A 200 bp negative regulatory region in the 5'-flanking sequence of the human beta-globin gene can be folded by HMG proteins 1 and 2 into a circular structure (diameter 70 +/- 6 A) with a linear tail which seems to be a left-handed double helix structure.
Qian
R L
RL
Shanghai Institute of Cell Biology, Academia Sinica, PRC.
Chen
Y D
YD
Hu
Y L
YL
Li
M Q
MQ
Wang
Z H
ZH
Xu
Y L
YL
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000648:ultrastructure; D005914:Globins / Q000235:genetics*; D006609:High Mobility Group Proteins / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D016252:Microscopy, Scanning Tunneling; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid
D006609:High Mobility Group Proteins; D005914:Globins; D004247:DNA