Antifungal agents. VI. In vitro antifungal activities of halobenzoyl esters of cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3- dioxolan-4-yl]carbinols.
The synthesis and the in vitro antifungal activities against Candida albicans and Candida spp of a number of halobenzoyl esters of cis- and trans- [2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4- yl]carbinols is reported. Some new imidazoles were found more active than ketoconazole and sometimes as potent as bifonazole against Candida albicans. All derivatives were found scarcely active against Candida spp.
Stefancich
G
G
Dipartamento di Scienze Farmaceutiche, Università di Trieste, Italy.
Silvestri
R
R
Pagnozzi
E
E
Artico
M
M
Retico
A
A
Apuzzo
G
G
Simonetti
N
N
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
D000935:Antifungal Agents; D001713:Biphenyl Compounds; D004148:Dioxolanes; D007093:Imidazoles; C036596:bifonazole; D007654:Ketoconazole