Actions of interleukin-2 on chorio-decidual prostaglandin biosynthesis.
The onset of preterm labor requires increased intrauterine prostaglandin production. Intrauterine infections are frequently associated with preterm labor and increased cytokine production. The cytokine interleukin-2 (IL-2) is a potent T-cell growth factor necessary for effective cell-mediated immunity. In this study we evaluated the effect IL-2 has on prostaglandin E2 (PGE2) biosynthesis by human chorion and decidual cells. IL-2 alone significantly stimulated decidual and chorion PGE2 production. IL-2 enhanced the stimulatory actions of interleukin-1 (IL-1), epidermal growth factor (EGF), ionomycin, and phorbol 12-myristate 13-acetate (PMA) on PGE2 production by decidual cells. Similarly, IL-2 enhanced the stimulatory actions of EGF and PMA, but not IL-1 or ionomycin, on PGE2 production by chorion cells. These data suggest that IL-2 could potentially participate in the mechanisms of preterm labor in association with intrauterine infection.
Coulam
C H
CH
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132.
Edwin
S S
SS
LaMarche
S
S
Mitchell
M D
MD
D002478:Cells, Cultured; D002823:Chorion / Q000378:metabolism*; D003656:Decidua / Q000378:metabolism*; D015232:Dinoprostone / Q000096:biosynthesis*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology*; D015759:Ionomycin / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007375:Interleukin-1; D007376:Interleukin-2; D015759:Ionomycin; D004815:Epidermal Growth Factor; D015232:Dinoprostone; D013755:Tetradecanoylphorbol Acetate