[Effect of lymphokine-activated killer cells of head and neck tumors in vitro and in nude mice].
Human lymphokine-activated killer (LAK) cells were prepared by culturing normal peripheral blood mononuclear cells (PBMC) for 4 days with or without added recombinant interleukin 2 (rIL-2) and assayed for anti-tumor activity against established squamous cell carcinoma lines of the head and neck (SCCHN) in vitro and in nude mice. The results showed that LAK cells had a stronger cytotoxicity than control cells to different SCCHN in vitro. In vivo, LAK cells almost completely inhibited the growth of HEP-2 tumor in nude mice and resulted in an inhibition rate of 81.6% (P < 0.01 with control cells). Our data indicate that LAK cells may be useful in the treatment of patients with head and neck tumors.
Duan
D S
DS
Peking Union Medical College Hospital, Beijing.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured