title: [Amoxycillin-clavulanic acid and cefuroxime axetil in the treatment of acute sinusitis. A clinical, radiological and bacteriological evaluation].
abstract: Cefuroxime axetil (CAE), an orally absorbed product of cefuroxime, and amoxycillin/clavulanate (AAC), were evaluated for their efficacy and safety in the treatment of acute sinusitis. A total of 47 patients were enrolled in a randomized study to compare cefuroxime axetil 500 mg. b.d. for 8 days (25 patients) with amoxycillin/clavulanate 500 mg. t.d.s for 8 days (22 patients). All patients were evaluable for clinical, radiological and bacteriological response. Of 25 clinically assessable patients treated with CAE, 24 were cured, 1 improved and 1 relapsed (96% success rate). Of 22 assessable patients given AAC, 14 were cured and 8 improved (100% success rate). Two out of 25 (8%) patients treated with CAE experienced drug-related adverse events, including 4% with diarrhoea. In the AAC group, 3 out of 22 (13%) patients had a drug-related adverse event, including 13% with diarrhoea. In conclusion, CAE appears to be as safe and effective as AAC in the treatment of acute sinusitis.
authors.affiliation: Servicio de ORL, Hospital Clínico y Provincial, Barcelona.
authors.forename: A
authors.initials: A
authors.lastname: Olmo
authors.forename: F
authors.initials: F
authors.lastname: Sabater
authors.forename: J
authors.initials: J
authors.lastname: Broto
authors.forename: J
authors.initials: J
authors.lastname: Traserra
mesh_terms: D000208:Acute Disease; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002444:Cefuroxime / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008297:Male; D011355:Prodrugs / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000145:classification / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D002969:Clavulanic Acids; D011355:Prodrugs; D019818:Clavulanic Acid; D000658:Amoxicillin; D002444:Cefuroxime; C040738:cefuroxime axetil
vernacular_title: Amoxicilina-ácido clavulánico y axetilo de cefuroxima en el tratamiento de la sinusitis aguda. Evaluación clínica, radiológica y bacteriológica.