Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice.
Aminophylline (theophylline2.ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous theophylline/kg). In contrast, 8-(p-sulfophenyl)theophylline (a theophylline derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.
Borowicz
K
K
Department of Pharmacology, Lublin Medical School, Poland.
Kozicka
M
M
Kleinrok
Z
Z
Czuczwar
S J
SJ
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010672:Phenytoin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control*; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology; D014635:Valproic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000927:Anticonvulsants; D000628:Aminophylline; D014635:Valproic Acid; D010672:Phenytoin; C031433:8-(4-sulfophenyl)theophylline; D013806:Theophylline; D010634:Phenobarbital