Selective immunosuppression.
Experimental models of autoimmune diseases have demonstrated that such disease can be prevented or treated by selectively interfering with activation of any of these cell types: antigen-presenting cells, autoreactive T cells and regulatory T cells. Luciano Adorini and colleagues discuss these approaches to selective immunosuppression and examine how similar strategies may become applicable to the treatment of human autoimmune diseases.
Adorini
L
L
Roche Milano Ricerche, Italy.
Guéry
J C
JC
Rodriguez-Tarduchy
G
G
Trembleau
S
S
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
D007166:Immunosuppressive Agents; D011948:Receptors, Antigen, T-Cell