Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis.
Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.
Bonte
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LVMH Recherche, Colombes, France.
Dumas
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M
Chaudagne
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C
Meybeck
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D000328:Adult; D002240:Carbohydrate Sequence; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D006801:Humans; D008969:Molecular Sequence Data; D053978:Pentacyclic Triterpenes; D013729:Terpenes / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
D053978:Pentacyclic Triterpenes; D013729:Terpenes; D014315:Triterpenes; D003094:Collagen; C017032:asiatic acid; C001669:madecassic acid; C004446:asiaticoside