CD8+ cytotoxic T cell therapy of cytomegalovirus and HIV infection.
The development of CD8+ cytotoxic T cell responses to viral pathogens is crucial for the prompt resolution of acute infections and for the control of viruses which persist in the host. Thus, cytomegalovirus often causes life threatening disease in immunosuppressed humans who fail to develop or maintain CD8+ cytotoxic T cells. Similarly, the loss of CD8+ cytotoxic T cell responses to HIV correlates with the development of AIDS. Recent investigations in the immunobiology of cytomegalovirus and HIV have resulted in the application of immunotherapeutic strategies designed to reconstitute or augment deficient CD8+ cytotoxic T cell responses to these human pathogens.
Riddell
S R
SR
Fred Hutchinson Cancer Research Center, Seattle.
Gilbert
M J
MJ
Greenberg
P D
PD
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy; D000818:Animals; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000628:therapy*; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007109:Immunity; D016219:Immunotherapy, Adoptive; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*