[Distribution of androgen receptors in bulbo-spinal muscular atrophy].
Immunohistochemical staining with anti-androgen receptor (AR) antibody was performed in skeletal muscle specimens obtained from 3 cases with bulbo-spinal muscular atrophy (BSMA) and 12 cases with other neuromuscular disease. Anti-AR antibody staining was found exclusively in the muscle nuclei of Type 2A fibers in all of the 3 cases. But there was no positive staining in the muscle nuclei of other disease. As above mentioned, very specific immuno-staining of AR in skeletal muscle would be of benefit to diagnosis of BSMA in addition to identification of a mutation of AR gene.
Murata
K
K
Department of Neurology, Nara Medical University.
Takayanagi
T
T
Araki
K
K
Murata
K
K
Mano
Y
Y
D000328:Adult; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D009132:Muscles / Q000737:chemistry; D009134:Muscular Atrophy, Spinal / Q000378:metabolism*; D011944:Receptors, Androgen / Q000032:analysis*
D011944:Receptors, Androgen