Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium.
C57BL/6 mice were pretreated with rifabutin or clarithromycin alone or combined with minocycline 3 days before intravenous challenge (day 0) with Mycobacterium avium. Treatment was continued until sacrifice at days 1, 8, 15, and 21. Rifabutin or clarithromycin decreased the level of infection in both the lungs and the spleen. Rifabutin was as effective as clarithromycin in the lungs but was less [corrected] effective in the spleen. The clarithromycin-minocycline combination was as effective as clarithromycin alone.
Lazard
T
T
Institut National de la Santé et de la Recherche Médicale, Unité 13, Hôpital Bichat-Claude Bernard, Paris, France.
Perronne
C
C
Grosset
J
J
Vilde
J L
JL
Pocidalo
J J
JJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017291:Clarithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology* / Q000627:therapeutic use*; D009162:Mycobacterium avium; D017828:Rifabutin / Q000494:pharmacology / Q000627:therapeutic use*; D012376:Rodent Diseases / Q000188:drug therapy / Q000517:prevention & control; D013154:Spleen / Q000187:drug effects / Q000382:microbiology; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy* / Q000517:prevention & control* / Q000662:veterinary
D000900:Anti-Bacterial Agents; D017828:Rifabutin; D008911:Minocycline; D017291:Clarithromycin