title: Abnormal platelet mitochondrial function in patients affected by migraine with and without aura.
abstract: To investigate energy metabolism in migraine, we determined platelet mitochondrial enzyme activities in 40 patients with migraine with aura and in 40 patients with migraine without aura during attack-free intervals and in 24 healthy control subjects. NADH-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities in both patient groups were significantly lower than in controls (p < 0.01), while NADH-cytochrome-c-reductase activity was reduced only in migraine with aura (p < 0.01). No alteration in succinate-dehydrogenase was observed. Monoamine-oxidase activity differed between sexes (p < 0.05) but within each sex group no difference was observed between patients and controls. We hypothesize that the defect in mitochondrial enzymes observed indicates a systemic impairment of mitochondrial function in migraine patients.
authors.affiliation: Institute of Neurology, University of Bologna, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sangiorgi
authors.forename: M
authors.initials: M
authors.lastname: Mochi
authors.forename: R
authors.initials: R
authors.lastname: Riva
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: L
authors.initials: L
authors.lastname: Monari
authors.forename: G
authors.initials: G
authors.lastname: Pierangeli
authors.forename: P
authors.initials: P
authors.lastname: Montagna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology / Q000502:physiology*; D002950:Citrate (si)-Synthase / Q000097:blood / Q000172:deficiency*; D030401:Cytochrome-c Oxidase Deficiency; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000097:blood; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000145:classification; D008928:Mitochondria / Q000201:enzymology / Q000502:physiology*; D008995:Monoamine Oxidase / Q000097:blood; D009245:NADH Dehydrogenase / Q000097:blood / Q000172:deficiency*; D013385:Succinate Dehydrogenase / Q000097:blood
chemical_list: D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D002950:Citrate (si)-Synthase