[The concept of receptor sorption as a basis for the development of nontraditional methods of therapy, prevention and diagnosis in pathological states].
A potential use of receptor sorption for medical purposes is discussed. This type of sorption is based on selective fixation of exo and endogenous chemical substances and viruses by their cellular receptors, which serve as sorbents, "landing grounds" ("chemical traps"). We propose to elaborate non-traditional methods of therapy, prophylaxis and diagnosis of various pathologies. These methods include: "dialysis by receptors", peroral and local use of isolated receptors, blocking of receptors by specific antireceptor antibodies, and analysis of binding properties of the receptors in various pathologies. We propose to carry out "receptor mapping" ("receptor classification") of the human population. This mapping consists in drawing up a "personal receptor map" carrying information about biochemical properties and binding parameters of the person's cellular receptors. The necessity of careful laboratory and clinical approbation of the proposed methods is emphasized.
Piruzian
L A
LA
Mikhaĭlovskiĭ
E M
EM
D000042:Absorption; D000327:Adsorption; D003933:Diagnosis; D006801:Humans; D011869:Radioligand Assay; D011956:Receptors, Cell Surface / Q000032:analysis / Q000145:classification / Q000378:metabolism*; D013812:Therapeutics / Q000379:methods*
D011956:Receptors, Cell Surface
Kontseptsiia retseptornoĭ sorbtsii kak osnova dlia razrabotki netraditsionnykh metodov terapii, profilaktiki i diagnostiki patologicheskikh sostoianiĭ.