title: Frequency specificity of amplitude-modulation-following response detected by phase spectral analysis.
abstract: To investigate the frequency specificity of steady-state responses elicited with a sinusoidally amplitude-modulated tone (amplitude-modulation-following response, AMFR), AMFR at different carrier frequencies were examined in 15 subjects with normal hearing, 12 patients with abrupt high-frequency hearing loss, 5 patients with low-frequency hearing loss and 1 patient with mid-frequency hearing loss. The stimulus was a sinusoidally amplitude-modulated tone with a modulation frequency of 40 Hz and modulation depth of 95%. Carrier frequencies were from 250 to 4000 Hz in normal subjects and from 250 to 8,000 Hz in hearing-impaired subjects. Fridman's phase spectral analysis was conducted for automatic detection of response. The thresholds of AMFR were distributed within 30 dB nHL at all carrier frequencies in normal subjects. In the hearing-impaired subjects, AMFR thresholds were between 0 and 25 dB above the behavioral threshold at all carrier frequencies. The threshold patterns of AMFR detected by phase spectral analysis very closely resembled the corresponding audiogram patterns in all types of hearing impairment. AMFR is thus shown to have a very good frequency specificity.
authors.affiliation: Department of Otolaryngology, Yamagata University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: T
authors.initials: T
authors.lastname: Kiren
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Fuse
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001301:Audiometry, Pure-Tone; D001307:Auditory Perception; D001309:Auditory Threshold; D005260:Female; D006309:Hearing / Q000502:physiology*; D006311:Hearing Disorders / Q000175:diagnosis*; D006801:Humans; D008297:Male