Two novel microbial conversion products of progesterone derivatives.
Two novel microbial steroid hydroxylations were found in a screening of 131 microorganisms under aerobic conditions. 17 alpha-Hydroxyprogesterone was hydroxylated in the 8 beta-position by Corynespora melonis CBS 16260, and fermentation of 17 alpha-acetoxyprogesterone with Pycnosporium species ATCC 12231 yielded 11 beta-hydroxy- and 11 beta, 12 beta-dihydroxy-17 alpha-acetoxyprogesterone. The known 11 beta-hydroxy compound could be obtained as a single product with Trichothecium roseum ATCC 12519.
Krischenowski
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Gesellschaft für Biotechnologische Forschung mbH, Research Group of Microbial Transformations, Braunschweig, Germany.
Kieslich
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K
D019326:17-alpha-Hydroxyprogesterone; D000523:Algestone / Q000737:chemistry / Q000378:metabolism; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000378:metabolism*; D015394:Molecular Structure; D011374:Progesterone / Q000737:chemistry / Q000378:metabolism*
D006908:Hydroxyprogesterones; D000523:Algestone; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone