A 28 kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation.
A 28 kDa-protein with inhibitory activity on collagen- and ADP-induced platelet aggregation was purified from the venom of the snake Bothrops jararaca. Its complete amino acid sequence corresponded to the carboxyl-terminal region consisting of disintegrin-like and cysteine-rich domains of jararhagin, a high molecular weight hemorrhagic metalloprotease. Sequence homology of the protein to other disintegrins and disintegrin-like proteins from various snake venoms is also presented.
Usami
Y
Y
Department of Pharmaceutics, Gifu Pharmaceutical University, Japan.
Fujimura
Y
Y
Miura
S
S
Shima
H
H
Yoshida
E
E
Yoshioka
A
A
Hirano
K
K
Suzuki
M
M
Titani
K
K
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000595:Amino Acid Sequence; D003094:Collagen / Q000037:antagonists & inhibitors; D003435:Crotalid Venoms / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008666:Metalloendopeptidases / Q000737:chemistry / Q000494:pharmacology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D000097146:Bothrops jararaca Venom
D000244:Adenosine Diphosphate; D003094:Collagen; D003435:Crotalid Venoms; D008666:Metalloendopeptidases; D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; D000097146:Bothrops jararaca Venom