title: The effect of nicotine and carbon monoxide on exercise performance in normal subjects.
abstract: In a partially blind randomized control study, nine healthy adult men performed progressive sub-maximal exercise tests, either after chewing nicotine chewing gum (4 mg) or breathing carbon monoxide (320 p.p.m.). Neither agent significantly affected exercise performance, despite a mean rise in blood nicotine to 17.0 ng ml-1 during nicotine administration and a COHb rise to 6.9% whilst breathing carbon monoxide. There was a significant rise in heart rate and blood pressure (P < 0.01) after nicotine administration. The reasons for absence of significant effect on cardiovascular or respiratory performance are discussed.
authors.affiliation: Royal Bournemouth Hospital, U.K.
authors.forename: J A
authors.initials: JA
authors.lastname: Turner
authors.forename: M W
authors.initials: MW
authors.lastname: McNicol
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002248:Carbon Monoxide / Q000494:pharmacology*; D017079:Exercise Tolerance / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D016037:Single-Blind Method
chemical_list: D009538:Nicotine; D002248:Carbon Monoxide