Multivariate and vectorial analysis of pharmacological signalling: diaphragm inositol 1,4,5-triphosphate under the duress of burn trauma.
Aberrant signal transduction processes within the diaphragm contribute to the weakness of this primary muscle involved in respiration. The importance of this report emphasizes how scald burn injury manifests distant systemic effects which impact on respiration. Scald burn injury from hot water is a common type of thermal injury in three specific patient groups: young children, the elderly, and the mentally and physically handicapped. Multivariate and vectorial analyses are presented within this paper with application to the effects of burn trauma on pharmacological signal transduction systems in the diaphragm. Multivariate equations showed the dependence of IP, on three to five independent variables. The independent variables included: burn size, glycerophosphate, and other polyinositols (inositol 1,4 biphosphate (I1,4P2), inositol 1 phosphate (I1P) and inositol). Graphic illustration of the equations used vectorial analysis. The multivariate analysis gives rise to a wider class of contributing factors than those observed using standard univariate relationships. This may be useful clinically in the identification of therapeutic agents for the treatment of respiratory problems in burn patients.
Tomera
J F
JF
Clinical Pharmacology Laboratory, Shriners Burns Institute, Boston, Massachusetts.
Lilford
K
K
D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology; D003964:Diaphragm / Q000378:metabolism* / Q000503:physiopathology; D005994:Glycerophosphates / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism; D051379:Mice; D015999:Multivariate Analysis; D015398:Signal Transduction; D013047:Specific Pathogen-Free Organisms
D005994:Glycerophosphates; D007295:Inositol Phosphates; C002647:inositol 1-phosphate; C044259:inositol 1,4-bis(phosphate); D007294:Inositol; D015544:Inositol 1,4,5-Trisphosphate