Interleukin-1 alpha as an autocrine growth factor for acute lymphoblastic leukaemia cells.
We describe a case of B-lineage acute lymphoblastic leukaemia (ALL) with proliferation of leukaemic cells through an interleukin-1 alpha (IL-1 alpha) autocrine mechanism. Flow cytometric analysis using the IL-1 receptor type II (IL-1Rt II) monoclonal antibody (mAb) demonstrated the expression of the IL-1Rt II on leukaemic cells: this is the first report in IL-1RtII-positive freshly isolated ALL cells from a patient. In accordance with the expression of IL-1RtII, the leukaemic cells proliferated in response to exogenous IL-1 alpha. In addition, anti-IL-1 alpha mAb markedly inhibited the spontaneous cell proliferation. Furthermore, Northern blot analysis detected IL-1 alpha mRNA without any stimulation. These observations suggest that IL-1 alpha may play an important role as an autocrine growth factor in some cases of ALL.
Mori
N
N
First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Shirakawa
F
F
Murakami
S
S
Oda
S
S
Eto
S
S
D000328:Adult; D002051:Burkitt Lymphoma / Q000097:blood / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D009363:Neoplasm Proteins / Q000097:blood; D017472:Receptors, Interleukin-1 / Q000032:analysis; D014407:Tumor Cells, Cultured
D007375:Interleukin-1; D009363:Neoplasm Proteins; D017472:Receptors, Interleukin-1