title: Relationship between cardiorespiratory fitness and lipoprotein(a) in men and women.
abstract: Lipoprotein(a) [Lp(a)] is a distinct lipoprotein of the low density lipoprotein (LDL) class. Research has shown that elevated Lp(a) is an independent risk factor for coronary heart disease (CHD). The purpose of this cross-sectional study was to determine whether fitness was associated with Lp(a) concentrations. Cardiorespiratory (CR) fitness, assessed by maximal treadmill time, percent body fat (hydrodensitometry), body fat distribution (waist/hip ratio), lipoprotein profile and LDL particle size (2-16% gel electrophoresis) were determined in healthy Caucasian men (N = 100) and women (N = 50). As expected, the frequency distribution of Lp(a) was highly skewed with a mean level of 16.9 +/- 19.1 mg.dl-1 (range 0.10-90 mg.dl-1) for men and women combined. Lp(a) was only significantly (P < 0.05) correlated with cholesterol (r = 0.29) in women and LDL-C (r = 0.22) in men. However, after correcting LDL-C for Lp(a) content, the correlation was not significant (r = 0.06). A MANCOVA, controlling for age, across highest and lowest CR fitness quartiles suggest a typical positive influence of improved CR fitness on lipoproteins, body composition, and fat distribution; however, Lp(a) levels were not affected. These data indicate that there is no direct association between plasma Lp(a) and body composition, fat distribution, or CR fitness in healthy men and women.
authors.affiliation: Department of Biochemistry, East Carolina University, Greenville, NC 27858-4353.
authors.forename: R G
authors.initials: RG
authors.lastname: Israel
authors.forename: M J
authors.initials: MJ
authors.lastname: Sullivan
authors.forename: R H
authors.initials: RH
authors.lastname: Marks
authors.forename: R S
authors.initials: RS
authors.lastname: Cayton
authors.forename: T C
authors.initials: TC
authors.lastname: Chenier
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000209:etiology / Q000235:genetics; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness / Q000502:physiology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D014280:Triglycerides; D002784:Cholesterol