Multi-infarct dementia in Down's syndrome.
In spite of a burgeoning literature on the association of Down's syndrome with Alzheimer's disease, the occurrence of multi-infarct dementia has largely been overlooked. A 55-year-old woman with Down's syndrome in whom a dementing process was associated with evidence of significant cerebrovascular disease is reported here. It is considered that she sustained both multi-infarct dementia and probable Alzheimer's disease. It is suggested that such cases are under-reported.
Collacott
R A
RA
Frith Hospital, Leicester, England.
Cooper
S A
SA
Ismail
I A
IA
D001921:Brain / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000503:physiopathology; D015161:Dementia, Multi-Infarct / Q000150:complications* / Q000503:physiopathology; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged