title: Functional brain imaging of a catatonic type of schizophrenia: PET and SPECT studies.
abstract: A brain imaging study was conducted in the case of a catatonic type of schizophrenia (DSM-IIIR) by applying (i) positron emission tomography (PET) and (ii) single photon emission computed tomography (SPECT). A PET study using [18F]-2-fluoro-2-deoxy-D-glucose revealed a lower glucose utilization in the dorsal frontal and parietal lobes of both cerebral hemispheres. Correlative SPECT studies using [123I]-iodoamphetamine showed a diminished regional cerebral blood flow in similar regions of the cerebral hemisphere. A three-dimensional volume rendering method of the SPECT images (TITAN) identified the dorsal region of the fronto-parietal lobe as the most severely affected region. These patterns of deficits implicated the role of the dorsal frontal and parietal lobes in the pathogenesis of catatonic syndromes.
authors.affiliation: Department of Psychiatry, Shiga. University of Medical Sciences, Otsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Narita
authors.forename: T
authors.initials: T
authors.lastname: Someya
authors.forename: H
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D003287:Contrast Media; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000502:physiology; D012560:Schizophrenia, Catatonic / Q000000981:diagnostic imaging* / Q000523:psychology
chemical_list: D001786:Blood Glucose; D003287:Contrast Media; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose