title: Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity.
abstract: Hb Poitiers or alpha 45(CE3)His-->Asp was found in a 9-year-old French Caucasian boy. The structural modification concerns a heme contact and is responsible for an increased oxygen affinity and a faster than normal rate of autooxidation.
authors.affiliation: INSERM U91, Hôpital Henri Mondor, Créteil, France.
authors.forename: J
authors.initials: J
authors.lastname: Bardakdjian
authors.forename: J
authors.initials: J
authors.lastname: Kister
authors.forename: H
authors.initials: H
authors.lastname: Wajcman
authors.forename: P
authors.initials: P
authors.lastname: Boulard
authors.forename: B
authors.initials: B
authors.lastname: Bohn
authors.forename: Y
authors.initials: Y
authors.lastname: Blouquit
authors.forename: F
authors.initials: F
authors.lastname: Galacteros
mesh_terms: D000740:Anemia / Q000097:blood / Q000235:genetics*; D001797:Blood Protein Electrophoresis; D002648:Child; D002852:Chromatography, Ion Exchange; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000097:blood / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D008297:Male; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; C087402:hemoglobin Poitiers; D005914:Globins; D010100:Oxygen