title: Near fatal pulmonary hypertension after surgical repair of congenital diaphragmatic hernia. Successful use of inhaled nitric oxide.
abstract: The addition of 10-20 parts per million nitric oxide to the inspired gas was successful in controlling near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia in a neonate. A preceding prostacyclin infusion was unable to prevent the failure of pulmonary perfusion. No side effect of nitric oxide therapy was observed, and ventilatory support could be substantially reduced as a result of the treatment. On the basis of the striking and lifesaving effects of nitric oxide therapy demonstrated in this child, we believe that nitric oxide treatment will prove to be a major contribution to the management of postoperative pulmonary hypertensive crises.
authors.affiliation: Department of Paediatric Anaesthesia and Intensive Care, St. Göran Hospital, Stockholm, Sweden.
authors.forename: C G
authors.initials: CG
authors.lastname: Frostell
authors.forename: P A
authors.initials: PA
authors.lastname: Lönnqvist
authors.forename: S E
authors.initials: SE
authors.lastname: Sonesson
authors.forename: L E
authors.initials: LE
authors.lastname: Gustafsson
authors.forename: G
authors.initials: G
authors.lastname: Löhr
authors.forename: G
authors.initials: G
authors.lastname: Noack
mesh_terms: D000138:Acidosis / Q000628:therapy; D000280:Administration, Inhalation; D005260:Female; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000628:therapy*; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000628:therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide