Increased trkB mRNA expression by axotomized motoneurones.
It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult rats. Thus, transection of the sciatic nerve resulted in markedly increased levels of trkB mRNA in axotomized motoneurones three days postinjury, while the levels had returned to normal within three weeks. The data support that neurotrophins may be important for survival and/or regeneration of motoneurones after axon lesion.
Piehl
F
F
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Frisén
J
J
Risling
M
M
Hökfelt
T
T
Cullheim
S
S
D000818:Animals; D001369:Axons / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D017403:In Situ Hybridization; D009046:Motor Neurons / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis*; D012584:Sciatic Nerve / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000201:enzymology
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases; C073922:neurotrophin 4