Partial trisomy 1q, an uncommon chromosomal aberration in erythroleukemia.
A 2 years 4 months old boy with erythroleukemia (FAB-M6) and Down's syndrome is described. Chromosome analysis of bone marrow leukemic blasts revealed apart from the trisomy 21 a partial trisomy of the long arm of chromosome 1:1q23-->1qter in all cells and trisomy 8 mosaicism. To the best of our knowledge this is the first time that a partial trisomy of chromosome 1 in association with erythroleukemia has been described. Previous reports of other hematologic malignancies with aberrations of chromosome 1 indicate that the breakpoint 1q23 is nonrandom and that trisomies of chromosome 1 plays a crucial role in the course of development of hematologic malignancies. This could probably also be true for erythroleukemias.
Baumgarten
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Universitätsklinik Rudolf Virchow, Charlottenburg, Kinderklinik Abt. Hämatologie/Onkologie, Berlin, Germany.
Wegner
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RD
Fengler
R
R
Koch
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H
Henze
G
G
D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002894:Chromosomes, Human, Pair 4 / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8; D004314:Down Syndrome / Q000150:complications; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D009030:Mosaicism; D014178:Translocation, Genetic; D014314:Trisomy