A long-term evaluation of the CIN-lesions. A clinicopathological study.
Among patients treated over a 20-year period cytological screening demonstrated a high-grade cervical dyscariosis (III-V Papanicolaou group) in 565 (2.3%) cases. In a group of 159 of these patients, all with cervical erythroplasia, a detailed study was possible and punch-biopsy (without colposcopy) was performed. Comparative analysis of cytology and pre-operative histology revealed good correlation. The patients in whom punch-biopsy demonstrated high-grade CIN and also those with negative histology, but with dyscariosis permanently occurring in cervicovaginal smears, underwent surgical treatment (conization). The results of histology in the punch-biopsies and in the surgical specimens of the cervix were discordant, mostly in low-grade CIN. Most patients are alive and well and remain in permanent clinical control. Conclusion--Cytology is a useful method of selecting the high-risk patients, who should subsequently be followed clinically, by cytology and histology. Surgical treatment seems to prevent invasive cancer: however these patients should remain under permanent control.
Niezabitowski
A
A
Maria Skłodowska-Curie, Memorial Cancer Center and Institute of Oncology, Cracow, Poland.
Medvey
W
W
D000328:Adult; D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D065006:Papanicolaou Test; D011044:Poland / Q000453:epidemiology; D012306:Risk; D016896:Treatment Outcome; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery; D014626:Vaginal Smears