title: Heredity, genes and osteoarthritis.
abstract: Human osteoarthritis (OA) is a heterogeneous and multifactorial disease with multiple pathogenetic mechanisms implicated in its development and progression. Despite its complex clinical expression, it appears that some forms of OA have a heritable component. This article briefly updates the reader on recent research that addresses the subject of heredity as one of significance in the etiology of OA.
authors.affiliation: Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: C J
authors.initials: CJ
authors.lastname: Williams
authors.forename: S A
authors.initials: SA
authors.lastname: Jimenez
mesh_terms: D000818:Animals; D001483:Base Sequence; D002357:Cartilage Diseases / Q000235:genetics; D003094:Collagen / Q000235:genetics; D005109:Extracellular Matrix / Q000502:physiology; D005544:Forecasting; D005796:Genes; D015316:Genetic Therapy; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010003:Osteoarthritis / Q000145:classification / Q000235:genetics* / Q000628:therapy; D010375:Pedigree
chemical_list: D003094:Collagen