Differential specific humoral response of susceptible and resistant mice infected with Mycobacterium lepraemurium.
C57BL/6 and BALB/c mouse strains were infected intraperitoneally with 10(8) Mycobacterium lepraemurium (MLM). At various stages of the infection, MLM-specific IgM, IgG, IgG1 and IgG2a serum antibodies were assessed. Anti-MLM antibody response varied markedly in both strains, in terms of antibody titres, Ig class distribution and kinetics of antibody secretion. C57BL/6 mice, which show intermediate resistance to MLM infection, presented the higher titres of IgM and IgG specific antibody, but without anti-MLM IgG1 detectable production. On the other hand, BALB/c susceptible strain showed a delayed but high IgG1 antibody production. Since it has been reported that Th2 lymphocyte subset modulate IgG1 antibody production, our results may reflect a differential activation of Th1 and Th2 cell subsets in both strains during a MLM infection.
Martínez-Abraján
D M
DM
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., Mexico.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000276:immunology*; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009161:Mycobacterium / Q000276:immunology*; D009164:Mycobacterium Infections / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M