title: Pathogenetic aspects of clinico-electrophysiological differentiation of transient cerebral circulation disorders terminating with a complete clinical recovery.
abstract: The present study offers a clinico-theoretical, electrophysiological and rheoencephalographic analysis of the brain matter condition and the cerebral hemodynamics of patients with acute cerebral circulation disorders which resolve with a complete clinical recovery. The purposes of the study were (1) to achieve pathogenetic differentiation of the syndromes of transient ischemic attacks (TIA) and reversible ischemic neurologic deficit (RIND) with greater confidence than that achieved by using the clinical criterion of "the neurologic deficit duration" (24 hours for TIAs, three weeks for RIND). (2) to determine the subclinical level in a single case, and (3) to develop a new approach to secondary prophylaxis in such patients. Fifty four patients (30 men and 24 women, mean age 57.2 +/- 1.9 years) presenting with acute ischemic disorders of cerebral circulation at the Clinic of Vascular Cerebral Diseases in the Department of Neurology of Plovdiv Medical University were followed up in the period between 1989 and 1991. On the 5th and 20th days of the episode onset the central latency time (CLT) of an evoked motor potential (MEP) was investigated on the symptomatic and asymptomatic sides. The study also involved rheoencephalography not only of the clinically followed-up population but also of 59 outpatients with TIA, 129 patients with RIND and 38 patients with an ischemic cerebral stroke. The results obtained objectify the differences among the researchers and confirm their views on the most common pathogenetic mechanisms associated with the occurrence and the course of the two forms of cerebral ischemia terminating with a complete clinical recovery.
authors.affiliation: Department of Neurology, University of Medicine, Plovdiv, Bulgaria.
authors.forename: E
authors.initials: E
authors.lastname: Hadzhipetrova
authors.forename: H
authors.initials: H
authors.lastname: Chalukova-Atanassova
authors.forename: T
authors.initials: T
authors.lastname: Vassileva
authors.forename: T
authors.initials: T
authors.lastname: Georgieva
mesh_terms: D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D004594:Electrophysiology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome