title: Clinical efficacy of doxycycline for pleurodesis.
abstract: To determine the efficacy of doxycycline as a pleural sclerosing agent, we examined the outcomes in 31 patients (aged 31 to 87 years) receiving doxycycline (500 to 1,000 mg) through a chest tube for malignant pleural effusions or persistent bronchopleural fistulae. Of the 27 patients with malignant pleural effusions, 21 patients had a complete short-term response (no fluid reaccumulation during the initial hospitalization); 5 of the 6 short-term nonresponders had partial control of effusions, with improvement in respiratory symptoms. Of the 23 patients who survived longer than 1 month, 15 patients did not have reaccumulation of fluid during follow-up. All four patients with persistent bronchopleural fistulae had resolution of their air leaks; one patient had recurrence with a partial pneumothorax. Pleural pain controllable with narcotic therapy was the only important complication. Thus, doxycycline is a suitable substitute for tetracycline as a pleural sclerosing agent.
authors.affiliation: Department of Medicine, St. Joseph's Hospital and Medical Center, Phoenix 85251.
authors.forename: J E
authors.initials: JE
authors.lastname: Heffner
authors.forename: R J
authors.initials: RJ
authors.lastname: Standerfer
authors.forename: J
authors.initials: J
authors.lastname: Torstveit
authors.forename: L
authors.initials: L
authors.lastname: Unruh
mesh_terms: D000368:Aged; D001983:Bronchial Fistula / Q000453:epidemiology / Q000628:therapy*; D015505:Chest Tubes; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D005402:Fistula / Q000453:epidemiology / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010995:Pleural Diseases / Q000453:epidemiology / Q000628:therapy*; D016066:Pleural Effusion, Malignant / Q000453:epidemiology / Q000628:therapy*; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012597:Sclerosing Solutions; D004318:Doxycycline