title: Vesnarinone inhibits production of HIV-1 in cultured cells.
abstract: Vesnarinone, a synthetic oral cardiotonic agent that has been used for treatment of patients with congestive heart failure, was found to inhibit replication of HIV-1 in a peripheral blood lymphocytes model and in chronically infected macrophages at clinically achieved concentrations. Vesnarinone has no direct inhibitory activity against the reverse transcriptase of HIV-1, syncytium formation in short term assays, or retroviral protease. In addition, vesnarinone inhibits production of TNF-alpha and IL-6 by human peripheral blood mononucleated cells stimulated with LPS. These observations suggest that vesnarinone may be therapeutically useful in patients infected with HIV-1.
authors.affiliation: Department of Clinical Medicine, School of Medicine, Kagoshima University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: I
authors.initials: I
authors.lastname: Kitajima
authors.forename: M
authors.initials: M
authors.lastname: Osame
authors.forename: J Q
authors.initials: JQ
authors.lastname: Zhao
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Nakai
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Yabu-uchi
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002459:Cell Fusion / Q000187:drug effects; D002469:Cell Separation; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D016333:HIV Protease / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000382:microbiology*; D008264:Macrophages / Q000382:microbiology; D011719:Pyrazines; D011804:Quinolines / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D011719:Pyrazines; D011804:Quinolines; C041667:vesnarinone; D016333:HIV Protease