Sequence of the sheep fetal beta globin gene and flanking region.
The sheep beta F globin gene has been sequenced completely, including 829 bases of 5' flanking region and 1368 bases 3' to the stop codon. In evolutionary terms, this gene is a homolog of the adult beta-like globin genes, including human beta. Over the course of evolution of Bovidae (comprised of sheep, goats, and cattle) the expression of beta F has become restricted to the fetal compartment of development. Comparisons between beta F and other closely related Bovidae beta globin genes indicate repetitive sequences that were inserted in these genes over the course of their divergence and a region which may be functionally significant to the developmentally regulated expression of beta F.
Saban
J
J
Department of Pharmacology and Molecular Biology, Chicago Medical School, IL 60064.
King
D
D
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA; D005333:Fetus; D005914:Globins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012756:Sheep
D005914:Globins; D004247:DNA