[Flow cytometric DNA analysis of colorectal carcinoma in adenoma].
We evaluated the DNA ploidy in 23 lesions of colorectal carcinoma in adenoma (CIA) and 90 adenomas without carcinomas by flow cytometry using fresh samples. DNA ploidy of carcinoma and adenoma components were assessed, respectively, with 17 paraffin-embedded samples of CIAs. The incidence of DNA aneuploidy (AP) was significantly higher in CIAs than in adenomas (47.8% vs. 12.2%, p < 0.01). Even in adenoma components of CIAs, AP tended to be found more frequent than in adenomas (41.2% vs. 12.2%). The incidence of AP in adenoma components was similar to that in carcinoma components (35.3%) in CIAs. In conclusion, DNA aneuploidy in adenomas may be a marker of malignant potential.
Fujino
Y
Y
First Dept. of Internal Medicine, Iwate Medical University, School of Medicine.
Fujimaki
E
E
Orii
S
S
Chiba
S
S
Nakano
O
O
Yamashiki
H
H
Sato
K
K
Sato
S
S
Sasaki
K
K
D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies
D004273:DNA, Neoplasm