Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents.
The effects of sesamin, a potent inhibitor of delta 5-desaturase in polyunsaturated fatty acid biosynthesis, on the fatty acid compositions of tissue lipids and liver functions were examined in rodents. When a mixture of sesamin and episesamin (51.1:48.2, w/w) was given to rats at a dietary level of 0.5% for 13 days, the proportions of dihomo-gamma-linolenic acid significantly increased not only in the liver but also in plasma and hemocytes, suggesting an interference with delta 5-desaturation by these lignans. The sesamin preparation at the dietary level of 1% improved changes in various blood parameters of the mouse, such as aspartate aminotransferase and alanine aminotransferase activities, and the concentrations of total cholesterol, triglyceride and total bilirubin, caused by continuous inhalation of ethanol. In addition, sesamin showed a significant protective effect against the accumulation of fat droplets and vacuolar degeneration in the mouse liver, as confirmed on histological examination. Sesamin, at the level of 100 mg/kg body weight, also tended to prevent liver lipid accumulation by carbon tetrachloride in mice. These results indicate that sesamin and a related lignan compound have an ability to improve liver function.
Akimoto
K
K
Institute for Biomedical Research, Suntory Ltd., Osaka, Japan.
Kitagawa
Y
Y
Akamatsu
T
T
Hirose
N
N
Sugano
M
M
Shimizu
S
S
Yamada
H
H
D000280:Administration, Inhalation; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D004149:Dioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D044943:Fatty Acid Desaturases / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D017705:Lignans; D050356:Lipid Metabolism; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004149:Dioxoles; D005227:Fatty Acids; D017705:Lignans; D000431:Ethanol; D002251:Carbon Tetrachloride; D044943:Fatty Acid Desaturases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C054125:sesamin