title: Nucleolar organizer regions in meningiomas.
abstract: Paraffin sections of 305 meningeal tumours were analysed for the presence of nucleolar organizer region (Ag-NOR) in the neoplastic cells, using a one step silver-colloidal staining method. The mean (+/- SEM) Ag-NOR counts were 2.73 +/- 0.21 for atypical and 2.91 +/- 0.18 for papillary variants of meningioma. In meningotheliomatous and transitional variants of meningioma, the mean Ag-NOR counts were 1.41 +/- 0.34 and 1.38 +/- 0.31, respectively. The recurrence rates were significantly higher in atypical meningiomas than in other histopathological variants (p < 0.05). Differences in the mean Ag-NOR numbers between meningothelial and transitional variants in their primary and recurrent tumours were not significantly different (p > 0.05). The results of this study indicates that estimation of Ag-NORs can be applied in predicting the aggressive clinical behaviour of primary meningeal tumours.
authors.affiliation: Department of Pathology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Radhakrishnan
authors.forename: N S
authors.initials: NS
authors.lastname: Radhakrishnan
authors.forename: D
authors.initials: D
authors.lastname: Rout
authors.forename: B K
authors.initials: BK
authors.lastname: Misna
mesh_terms: D001921:Brain / Q000648:ultrastructure; D002455:Cell Division / Q000502:physiology; D006801:Humans; D008577:Meningeal Neoplasms / Q000601:surgery / Q000648:ultrastructure*; D008578:Meninges / Q000648:ultrastructure; D008579:Meningioma / Q000601:surgery / Q000648:ultrastructure*; D009364:Neoplasm Recurrence, Local / Q000601:surgery / Q000648:ultrastructure*; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D011379:Prognosis; D012086:Reoperation