title: Parvovirus B19-associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia.
abstract: A 36-year-old man who had been treated for Evans syndrome (ES) developed an aplastic crisis caused by acute human parvovirus B19 (HPV) infection. Profound thrombocytopenia (8.0 x 10(9)/l) followed with a sudden increase in platelet-associated IgG (PAIgG) (1376.9 ng/10(7) plts). Bone marrow examination revealed a considerable number of haemophagocytic histiocytes without any disturbance of megakaryopoiesis. To our knowledge this is the first case of aplastic crisis with virus-associated haemophagocytosis in a patient with ES, which provides an interesting insight into the mechanisms for thrombocytopenia in HPV infection.
authors.affiliation: Department of Haematology, National Kyushu Cancer Centre, Fukuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Uike
authors.forename: T
authors.initials: T
authors.lastname: Miyamura
authors.forename: K
authors.initials: K
authors.lastname: Obama
authors.forename: H
authors.initials: H
authors.lastname: Takahira
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Kozuru
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000150:complications*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016732:Parvovirus B19, Human; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D004279:DNA, Viral