title: Human papillomavirus infections of the genital region in human immunodeficiency virus seropositive women: integration of type 16 correlates with rapid progression.
abstract: The efficacy of treatment of HPV infections was evaluated in 14 HIV-1 seropositive women. Disease evolution was evaluated at follow-up examinations, and findings were compared to those in 14 historic HIV-negative women who had received similar treatment. HPV sequences were demonstrated by Southern blot in 13/14 HIV-positive women and by in situ hybridization in 5/13 HIV-negative women. Types 6/11, 16, and 31/33/35 were equally distributed in both groups; type 18 was never detected. In all but one case, the same viral type was present in different lesions, and in recurrences. Among the HIV-positive women, integration of viral sequences had occurred in the dysplastic lesions in 2 of the 3 HPV-16-positive cases; both cases showed progression to carcinoma in situ within 1 to 2 years. Despite comparable treatment, the HIV-positive women showed lesion persistence or progression, while all HIV-negative women experienced regression.
authors.affiliation: Institute of Oncology, University of Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Del Mistro
authors.forename: E
authors.initials: E
authors.lastname: Insacco
authors.forename: A
authors.initials: A
authors.lastname: Cinel
authors.forename: L
authors.initials: L
authors.lastname: Bonaldi
authors.forename: D
authors.initials: D
authors.lastname: Minucci
authors.forename: L
authors.initials: L
authors.lastname: Chieco-Bianchi
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000821:virology; D002471:Cell Transformation, Neoplastic; D003218:Condylomata Acuminata / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000150:complications / Q000821:virology*; D005833:Genital Neoplasms, Female / Q000821:virology; D006679:HIV Seropositivity / Q000150:complications*; D015497:HIV-1; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000150:complications*
chemical_list: D004279:DNA, Viral