(6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway.
(6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 micrograms ml-1), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight-1). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine.
Davies
G M
GM
ZENECA Pharmaceuticals, Alderly Park, Macclesfield, United Kingdom.
Barrett-Bee
K J
KJ
Jude
D A
DA
Lehan
M
M
Nichols
W W
WW
Pinder
P E
PE
Thain
J L
JL
Watkins
W J
WJ
Wilson
R G
RG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000517:prevention & control; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000378:metabolism* / Q000494:pharmacology; D013552:Swine
C087313:6-fluoroshikimic acid; D000900:Anti-Bacterial Agents; D012765:Shikimic Acid