title: Simultaneous relapse of liver cell carcinoma and non-Hodgkin's lymphoma in the liver. Report of a case with diagnosis by ultrasonically guided fine needle aspiration biopsy.
abstract: A 50-year-old man was diagnosed with non-Hodgkin's lymphoma (NHL) in 1980; he was treated with chemotherapy and achieved complete remission. Six years later he reported upper abdominal pain. Ultrasound (US) showed a 3-cm mass in the right lobe of the liver. Needle aspiration showed hepatocellular carcinoma (HCC). The patient was treated with radical resection of the tumor. Three years later (June 1989), abdominal US showed two lesions in the right lobe of the liver. Needle aspiration and tissue core biopsy showed NHL in one lesion and HCC in the other. The lymphomatous lesion resolved after chemotherapy. The patient died 30 months later (January 1992) from a gastrointestinal hemorrhage; the NHL was in complete remission. This case of the simultaneous presence of HCC and hepatic lymphoma is, to our knowledge, the first diagnosed in vivo.
authors.affiliation: First Department of Internal Medicine, City Hospital of Piacenza, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cavanna
authors.forename: G
authors.initials: G
authors.lastname: Civardi
authors.forename: F
authors.initials: F
authors.lastname: Fornari
authors.forename: D
authors.initials: D
authors.lastname: Vallisa
authors.forename: R
authors.initials: R
authors.lastname: Berte
authors.forename: E
authors.initials: E
authors.lastname: Buscarini
authors.forename: G
authors.initials: G
authors.lastname: Sbolli
authors.forename: C
authors.initials: C
authors.lastname: Paties
authors.forename: R
authors.initials: R
authors.lastname: Foroni
authors.forename: M
authors.initials: M
authors.lastname: Di Stasi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle / Q000379:methods; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D014463:Ultrasonography / Q000379:methods; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone