title: Osmotic blood-brain barrier disruption: CT and radionuclide imaging.
abstract: OBJECTIVE
  To compare CT and radionuclide imaging of osmotic blood-brain barrier disruption. To develop a quantitative method for imaging osmotic blood-brain barrier disruption and to see if iopamidol could be safely given intravenously in conjunction with blood-brain barrier disruption.
  
  
  METHODS
  Forty-five blood-brain barrier disruption procedures were imaged with CT and radionuclide scans. The scans were evaluated with visual and quantitative scales. Patients were observed for adverse effects after blood-brain barrier disruption.
  
  
  RESULTS
  There was a 4% rate of seizures in this study. There was good agreement between visual CT and radionuclide grading systems. Quantitative methods to grade disruption did not add useful information to visual interpretations.
  
  
  CONCLUSIONS
  Nonionic iodine-based contrast medium has a lower incidence of seizures when injected intravenously in conjunction with osmotic blood-brain barrier disruption than ionic contrast material. Contrast-enhanced CT is the preferred method to image disruption because it has better spatial resolution than radionuclide techniques.
authors.affiliation: Oregon Health Sciences University, Portland 97201-3098.
authors.forename: S
authors.initials: S
authors.lastname: Roman-Goldstein
authors.forename: D A
authors.initials: DA
authors.lastname: Clunie
authors.forename: J
authors.initials: J
authors.lastname: Stevens
authors.forename: R
authors.initials: R
authors.lastname: Hogan
authors.forename: J
authors.initials: J
authors.lastname: Monard
authors.forename: F
authors.initials: F
authors.lastname: Ramsey
authors.forename: E A
authors.initials: EA
authors.lastname: Neuwelt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000502:physiology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007479:Iopamidol; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D009995:Osmosis; D011877:Radionuclide Imaging; D013400:Sugar Acids; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D013400:Sugar Acids; C100014:technetium Tc 99m gluceptate; D007479:Iopamidol