title: Intracranial germ cell tumors: a comprehensive update of the European data.
abstract: Intracranial germ cell tumors are rare tumor entities in childhood and adolescents. Extra- and intracranial germ cell tumors are identical in their histologic pattern and occur in preferential midline localizations such as the pineal and the suprasellar region. Germ cell neoplasms show increasing incidence rates over the last 30 years. The majority of intracranial germ cell neoplasms are germinomas. About 90% of the patients with pure germinomas can be salvaged by radiotherapy alone according to modern protocols. Non-germinomatous malignant CNS-germ cell tumors are considered to have a poor prognosis. In order to improve the survival of patients affected by these tumors different treatment approaches adding chemotherapy to conventional surgery and radiotherapy have been initiated by various study groups throughout the world. Due to the rarity of these neoplasms only a very limited number of patients has been enrolled in each study. In 1993 an international working group on these tumors was established by the International Society of Pediatric Oncology (SIOP).
authors.affiliation: Children's Hospital, University of Düsseldorf, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Calaminus
authors.forename: M
authors.initials: M
authors.lastname: Bamberg
authors.forename: M C
authors.initials: MC
authors.lastname: Baranzelli
authors.forename: Y
authors.initials: Y
authors.lastname: Benoit
authors.forename: L C
authors.initials: LC
authors.lastname: di Montezemolo
authors.forename: F
authors.initials: F
authors.lastname: Fossati-Bellani
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: H J
authors.initials: HJ
authors.lastname: Kühl
authors.forename: H G
authors.initials: HG
authors.lastname: Lenard
authors.forename: M L
authors.initials: ML
authors.lastname: Curto
mesh_terms: D001921:Brain / Q000473:pathology*; D003131:Combined Modality Therapy; D004358:Drug Therapy; D005602:France / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D018237:Germinoma / Q000188:drug therapy / Q000453:epidemiology* / Q000532:radiotherapy; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010984:Platinum / Q000627:therapeutic use; D011379:Prognosis; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D010984:Platinum