title: Epidemiology of resistance to diaminopyrimidines.
abstract: Resistance to trimethoprim emerged in Enterobacteriaceae and later in other Gram-negative and Gram-positive bacteria within two years of the clinical introduction of the drug. Resistance is borne in many different replicons often present in multiply-resistant epidemic bacteria. The incidence of trimethoprim resistance is highly variable, depending upon methodology, type of patients, local epidemiology: this can be illustrated by the high variation of trimethoprim resistance among Salmonella, Shigella or MRSA in various countries and by the incidence of resistance in penicillin-resistant Streptococcus pneumoniae.
authors.affiliation: Hôpital Saint-Joseph, Laboratoire de Microbiologie Médicale, Paris, France.
authors.forename: F W
authors.initials: FW
authors.lastname: Goldstein
authors.forename: J F
authors.initials: JF
authors.lastname: Acar
mesh_terms: D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology; D004812:Epidemiologic Methods; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D011743:Pyrimidines / Q000494:pharmacology*; D014296:Trimethoprim Resistance
chemical_list: D011743:Pyrimidines