title: Modification of increasing systolic blood pressure in the elderly during the 1980s.
abstract: The authors examined whether changing attitudes and approaches to modifying blood pressure during the 1980s affected the previously described pattern of increasing systolic blood pressure in the elderly which continues through the ninth decade of life. In 1982-1983, a door-to-door census identified 4,497 community-dwelling residents of East Boston, Massachusetts aged 65 and over, of whom 3,657 had baseline blood pressure assessments. Follow-up blood pressure assessments occurred in 1985-1986 and in 1988-1989. Cross-sectionally, the relation of age with systolic blood pressure was quadratic with levels predicted to increase until about age 84 after which they were lower among oldest-old survivors. Longitudinally, mean age-sex-adjusted systolic blood pressure was 3.3 mmHg lower in 1985-1986 compared with 1982-1983 (95 percent confidence interval (CI) 2.4-4.2 mmHg) and 10.6 mmHg lower in 1988-1989 compared with 1982-1983 (95 percent CI 9.5-11.7 mmHg). Utilization of antihypertension medications increased over time and accounted for some, but not all, of the observed decreases in systolic blood pressure. Large shifts occurred in the use of specific antihypertension medications including increases in use of angiotensin converting enzyme inhibitors and calcium entry blockers and decreases in use of thiazide diuretics. Previously described trends for increasing systolic blood pressure in the elderly were reversed during the 1980s when the continued decline in cardiovascular mortality was greatest among the elderly.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204.
authors.forename: R J
authors.initials: RJ
authors.lastname: Glynn
authors.forename: T S
authors.initials: TS
authors.lastname: Field
authors.forename: S
authors.initials: S
authors.lastname: Satterfield
authors.forename: P R
authors.initials: PR
authors.lastname: Hebert
authors.forename: J E
authors.initials: JE
authors.lastname: Buring
authors.forename: J O
authors.initials: JO
authors.lastname: Taylor
authors.forename: C H
authors.initials: CH
authors.lastname: Hennekens
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003430:Cross-Sectional Studies; D004363:Drug Utilization; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016014:Linear Models; D008297:Male; D017678:Sex Distribution; D013599:Systole
chemical_list: D000959:Antihypertensive Agents