Experimental study of subacute oral, dermal and inhalation toxicity of bulmoscide preparation.
The purpose of this study is to give the toxicological characteristics of subacute oral, dermal and inhalation exposure of microbial preparation Bulmoscide, which is based on bacterium Bacillus thuringiensis, serotype H-14. The study was performed on sexually mature Wistar rats of both sexes. No significant changes in non-specific, clinico-laboratory and biochemical parameters as well as morphological examinations in any tested groups compared to the control groups were revealed. The doses 110 mg.kg-1 (1.32 x 10(9) sp.kg-1) at oral administration in duration of 90 days, 3000 mg.kg-1 (3.6 x 10(10) sp.kg-1) in 21 day dermal application and maximum attainable concentration of dust aerosol 18 mg.kg-3 (2.2 x 10(8) sp.m-3) during a 30 day inhalation exposure are "no toxic effect" levels. On the basis of the data, the selective bacterial insecticide Bulmoscide has been determined to be of low toxic and low hazardous preparation in compliance with the Hygiene Classification of pesticides.
Halkova
Z
Z
Department of Industrial Toxicology, National Center of Hygiene and Medical Ecology, Sofia, Bulgaria.
Zaykov
C
C
Antov
G
G
Mihaylova
A
A
Mircheva
V
V
Dinoeva
S
S
Chipilska
L
L
D000279:Administration, Cutaneous; D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001769:Blood / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009930:Organic Chemicals; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects
D007306:Insecticides; D009930:Organic Chemicals; C084026:bulmoscide