title: Immune-based resistance to the formation of v-src-induced distal tumors.
abstract: Although v-src, the oncogene of Rous sarcoma virus, has been shown to be capable of inducing lethal tumors at visceral sites distal to the primary tumor mass, the mechanisms opposing visceral tumor formation remain to be elucidated. In the present study, we show that visceral tumors, many of which represent a metastasis spawned by the primary mass, are found only in hosts exhibiting reduced levels of tumor immunity. We conclude that it is the weakness of the tumor immune response, rather than a lack of expression of tumor antigen on visceral tumor cells, that is a major underpinning of the formation of v-src-induced visceral tumors.
authors.affiliation: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
authors.forename: M S
authors.initials: MS
authors.lastname: Halpern
authors.forename: T W
authors.initials: TW
authors.lastname: Wisner
authors.forename: I P
authors.initials: IP
authors.lastname: Brown
authors.forename: J M
authors.initials: JM
authors.lastname: England
mesh_terms: D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D002455:Cell Division; D002645:Chickens; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D016391:Genes, src; D007113:Immunity, Innate / Q000276:immunology*; D007700:Kinetics; D015183:Restriction Mapping; D001357:Sarcoma, Avian / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
chemical_list: D004273:DNA, Neoplasm; D004279:DNA, Viral