The effect of long-chain N-acylethanolamines on some membrane-associated functions of neuroblastoma C1300 N18 cells.
As reported earlier (Gulaya, N.M., Vaskovsky, V.E., Vystosky, M.V., Volkov, G.L., Govseeva, N.N. and Artemenko, I.P. (1988) Ukr. Biochim. J. 60, 58-63), N-acylphosphatidylethanolamines (NAPE) and products of their catabolism, N-acylethanolamines (NAE), are present in the lipids of neuroblastoma C1300 N18 undifferentiated cells. The present paper describes the distribution of NAE added to culture medium of differentiated cells and its effect on the fast sodium channels and some other membrane characteristics. It is shown that NAE inhibits the destroying action of veratridine on membranes.
Gulaya
N M
NM
Department of Lipid Biochemistry, A.V. Palladin Institute of Biochemistry, Academy of Sciences, Kiev, Ukraine.
Melnik
A A
AA
Balkov
D I
DI
Volkov
G L
GL
Vysotskiy
M V
MV
Vaskovsky
V E
VE
D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D050356:Lipid Metabolism; D008246:Lysophospholipids / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D015222:Sodium Channels / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014701:Veratridine / Q000037:antagonists & inhibitors
D004983:Ethanolamines; D008246:Lysophospholipids; C022203:N-acylethanolamines; D010714:Phosphatidylethanolamines; D015222:Sodium Channels; D014701:Veratridine