Biliary atresia--bile acids and prostaglandin E2 in cell cultures of bile duct epithelia.
In a cell culture model of bile duct epithelial cells, the effect of prostaglandin E2, lithocholic acid and deoxycholic acid was studied. Bile acids and prostaglandin are administered postoperatively in biliary atresia empirically as choleretics. Prostaglandin E2 and the bile acids all had inhibitory effects on bile duct epithelial cells in culture. There is no clinical study proving the efficacy of either bile acids or prostaglandin E2 in biliary atresia. The negative results with these substances in cell cultures warrants reserve in their routine clinical use in biliary atresia.
Schier
F
F
Department of Pediatric Surgery, University Medical Center Steglitz, Berlin, Germany.
Schier
C
C
Gehrke
I
I
Gehrke
T
T
Waldschmidt
J
J
D000328:Adult; D000818:Animals; D001652:Bile Ducts / Q000002:abnormalities / Q000187:drug effects* / Q000473:pathology; D001656:Biliary Atresia / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D003840:Deoxycholic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D015232:Dinoprostone / Q000494:pharmacology* / Q000627:therapeutic use; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D006131:Growth Inhibitors; D006801:Humans; D008095:Lithocholic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D011182:Postoperative Care
D006131:Growth Inhibitors; D003840:Deoxycholic Acid; D008095:Lithocholic Acid; D015232:Dinoprostone