title: High-titer antinuclear antibodies, anti-SSA/Ro antibodies and anti-nuclear RNP antibodies in patients with idiopathic thrombocytopenic purpura.
abstract: The clinical significance of high-titer antinuclear antibodies (ANA) and autoantibodies to cellular antigens such as SSA/Ro and nuclear RNP (nRNP) antigens in idiopathic thrombocytopenic purpura (ITP) was examined in a prospective evaluation of 66 adult patients with chronic ITP. ANA were positive in 29 (44%) of 66 patients with chronic ITP. The titers of ANA were high (1:160 or higher) in 14 of 29 ANA-positive patients. Furthermore, 10 of 66 patients had precipitating antibodies to nuclear antigens; seven patients had anti-SSA/Ro antibodies and the other three had anti-nRNP antibodies. None of high-titer ANA- or precipitating antibody-positive patients developed systemic lupus erythematosus (SLE) throughout the follow-up period of 3 years. In addition, we investigated retrospectively precipitating antibodies in stocked sera from 8 patients. These patients had already precipitating antibodies average of 7.7 years before. None of 8 patients developed SLE or Sjogren's syndrome (SS). These data demonstrate that high-titer ANA and antibodies to SSA/Ro or nRNP antigens are often found in patients with ITP, and indicate that the detection of high-titer ANA or the existence of antibodies to SSA/Ro or nRNP antigens by itself is not enough to identify those patients with ITP who are at risk of developing SLE or SS.
authors.affiliation: Department of Blood Transfusion, Osaka University Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kurata
authors.forename: S
authors.initials: S
authors.lastname: Miyagawa
authors.forename: S
authors.initials: S
authors.lastname: Kosugi
authors.forename: H
authors.initials: H
authors.lastname: Kashiwagi
authors.forename: S
authors.initials: S
authors.lastname: Honda
authors.forename: H
authors.initials: H
authors.lastname: Mizutani
authors.forename: Y
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kanayama
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001324:Autoantigens; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011233:Precipitin Tests; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000209:etiology; D013997:Time Factors; D055517:snRNP Core Proteins
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; C035356:SS-A antibodies; D055517:snRNP Core Proteins