In vitro postantibiotic effect following repeated exposure to imipenem, temafloxacin, and tobramycin.
The postantibiotic effect (PAE) following three consecutive 2-h exposures to imipenem, temafloxacin, and tobramycin was determined in Pseudomonas aeruginosa. A PAE and a bactericidal effect were consistently observed for imipenem following each cycle of drug exposure and regrowth. In contrast, the PAE increased with repeated exposure with temafloxacin (1.8 to > 5 h), but disappeared with tobramycin by the third exposure (0.9 to 0 h). These data show that the in vitro PAE may change within a strain following multiple cycles of drug exposure and bacterial regrowth.
McGrath
B J
BJ
Antiinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy, Roger Williams Medical Center, Providence 02908.
Marchbanks
C R
CR
Gilbert
D
D
Dudley
M N
MN
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*; D013997:Time Factors; D014031:Tobramycin / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C054745:temafloxacin; D015378:Imipenem; D014031:Tobramycin