title: Survival and prognostic factors in patients with localised cutaneous melanoma observed between 1980 and 1991 at the Istituto Dermopatico dell'Immacolata in Rome, Italy.
abstract: 530 patients with localised cutaneous melanoma consecutively observed between 1980 and 1991 at a hospital for skin diseases in Rome, Italy, were studied. Crude survival proportions were calculated with the method of Kaplan and Meier. Cox proportional hazards regression analysis was used to estimate the effect of prognostic factors on death rates. Females and younger patients had better 5- and 10-year survival rates, while increasing tumour thickness was associated with a decrease in survival time. In the multivariate analysis, an independent association with survival was found for tumour thickness, presence of ulceration, age, sex and cross-sectional profile of neoplasia. Our study confirms that females and young patients with thin melanomas have a better prognosis, while the importance of cross-sectional profile needs further study.
authors.affiliation: Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IDIIRCCS), Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Corona
authors.forename: M
authors.initials: M
authors.lastname: Sciò
authors.forename: A
authors.initials: A
authors.lastname: Mele
authors.forename: G
authors.initials: G
authors.lastname: Ferranti
authors.forename: S
authors.initials: S
authors.lastname: Mostaccioli
authors.forename: V
authors.initials: V
authors.lastname: Macchini
authors.forename: G
authors.initials: G
authors.lastname: Sonego
authors.forename: L
authors.initials: L
authors.lastname: Ferrigno
authors.forename: M
authors.initials: M
authors.lastname: Fucci
authors.forename: J F
authors.initials: JF
authors.lastname: Osborn
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000401:mortality* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis; D013997:Time Factors