title: CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptor.
authors.affiliation: Department of Neuroscience, Pfizer, Inc., Groton, CT 06340.
authors.forename: S
authors.initials: S
authors.lastname: McLean
authors.forename: R M
authors.initials: RM
authors.lastname: Snider
authors.forename: M C
authors.initials: MC
authors.lastname: Desai
authors.forename: T
authors.initials: T
authors.lastname: Rosen
authors.forename: D K
authors.initials: DK
authors.lastname: Bryce
authors.forename: K P
authors.initials: KP
authors.lastname: Longo
authors.forename: A W
authors.initials: AW
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Heym
mesh_terms: D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001667:Binding, Competitive; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002211:Capsaicin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007700:Kinetics; D008168:Lung / Q000187:drug effects / Q000502:physiology; D015288:Neurokinin A / Q000037:antagonists & inhibitors*; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000378:metabolism / Q000494:pharmacology*; D018040:Receptors, Neurokinin-1 / Q000378:metabolism / Q000502:physiology; D015244:Thiorphan / Q000494:pharmacology; D014700:Verapamil / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D018040:Receptors, Neurokinin-1; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D015288:Neurokinin A; C043184:4-desmethoxyverapamil; D015244:Thiorphan; D014700:Verapamil; D000420:Albuterol; D002211:Capsaicin