title: An outbreak of parvovirus B19 infection; a study of clinical manifestations and the incidence of fetal loss.
abstract: Eighty-five cases of B19 infection were diagnosed in Northern Ireland from 1984 to 1989; 65 of these occurred during 1989, the outbreak year. Of the total 85 cases, 15 had a rash, 21 had arthralgia, 47 had a rash and arthralgia, and 2 had aplastic crisis. The age range was 4-63 years with a mean of 26.9 years. Thirty cases (35%) were referred to hospital; 25 of these had arthralgia and 2 had aplastic crisis. Two thousand four hundred pregnant women at 12 weeks gestation in 1989 were screened for anti-B19 IgM; 8 were positive. Of these 8 patients, 7 progressed to delivery of a normal fetus and one had an intra-uterine death at 26 weeks gestation; no congenital abnormalities were noted in any fetus. The incidence of fetal involvement in maternal B19 infection in this study was therefore 12.5%.
authors.affiliation: Royal Victoria Hospital, Belfast.
authors.forename: J R
authors.initials: JR
authors.lastname: Kerr
authors.forename: H J
authors.initials: HJ
authors.lastname: O'Neill
authors.forename: P V
authors.initials: PV
authors.lastname: Coyle
authors.forename: W
authors.initials: W
authors.lastname: Thompson
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D016731:Erythema Infectiosum / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005313:Fetal Death / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D016732:Parvovirus B19, Human; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology