Hypercalcaemia in small cell lung cancer: report of a case associated with parathyroid hormone-related protein (PTHrP).
Although hypercalcaemia is frequently associated with malignancy, it is very rare in small cell lung cancer despite the high incidence of lytic bone metastases. We report a patient with extensive small cell cancer who presented with hypercalcaemia. Investigations suggested parathyroid hormone (PTH) receptor stimulation, although the serum PTH level was not elevated. PTH related protein (PTHrP) was localised in a biopsy specimen from the tumour. Although hypercalcaemia is rare in small cell lung cancer, when hypercalcaemia does occur, PTHrP may be a causal factor.
Stuart-Harris
R
R
Sacred Heart Hospice, Darlinghurst NSW, Australia.
Ahern
V
V
Danks
J A
JA
Gurney
H
H
Martin
T J
TJ
D000368:Aged; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins