Pharmacological modulation of 5-fluorouracil and its clinical implications: an overview.
Authors present an overview of the present knowledge in the field of biochemical modulation of 5-fluorouracil and its potential clinical applications. Interaction between 5-fluorouracil and several modulators, such as leucovorin, interferons, cisplatin, hydroxyurea, thymidine, methotrexate, and PALA are extensively analyzed.
Gebbia
V
V
Institute of Pharmacology, University of Palermo, Italy.
Testa
A
A
Borsellino
N
N
Cannata
G
G
Valenza
R
R
Gebbia
N
N
D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D005472:Fluorouracil