Formation of fatty acid propyl esters in liver, lung and pancreas of rats administered 1-propanol.
The esterification of fatty acids by ethanol has been associated with a number of adverse reactions. In this study, the administration of 1-propanol (3 ml/kg 24 and 12 hours prior to measurements) to rats resulted in the formation of fatty acid propyl esters of oleic acid, lauric acid and to a lesser extent, palmitic acid and myristic acid. Formation was highest in liver and pancreas and was lower in lung.
Carlson
G P
GP
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.
D000433:1-Propanol / Q000633:toxicity*; D000818:Animals; D004951:Esterification; D005227:Fatty Acids / Q000378:metabolism*; D007850:Lauric Acids / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019814:Myristic Acid; D009227:Myristic Acids / Q000378:metabolism; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D005227:Fatty Acids; D007850:Lauric Acids; D009227:Myristic Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D019814:Myristic Acid; C030358:lauric acid; D019301:Oleic Acid; D019308:Palmitic Acid; D000433:1-Propanol