Thromboplastin activities and monocytes in the coronary circulation of reperfused human myocardium. No effect of preoperative treatment with n-3 fatty acids.
In a double-blind study 18 patients were randomized to receive a daily dietary supplement of concentrated ethyl ester compound of n-3 fatty acids or placebo (corn oil) for at least 6 weeks before coronary bypass surgery. Three-fold increase of serum eicosapentaenoic acid and 20% reduction of triglyceride levels were found preoperatively in the n-3 group, while the two groups were similar as regards monocyte and platelet counts, mean platelet volume and monocyte activation as expressed by thromboplastin activities. For determination of transcardiac gradients, coronary sinus and aortic blood were sampled preoperatively 5, 10 and 30 minutes after release of the aortic cross-clamp. In both patient groups the monocyte count was lower in coronary sinus than in aortic blood at 5 and 10 minutes, but the differences were not significant. The platelet counts showed no significant change. In vitro stimulation of monocytes, however, evoked significantly (p < 0.05) less thromboplastin activity in coronary sinus blood than in aortic blood at all three sampling times, without significant intergroup difference. The monocytes most sensitive to activation presumably were trapped in the reperfused myocardium, and this sequestration was not hindered by pretreatment with n-3 fatty acids.
Almdahl
S M
SM
Department of Surgery, University of Tromsø, Norway.
Nilsen
D W
DW
Osterud
B
B
Sørlie
D G
DG
Vaage
J
J
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology / Q000601:surgery*; D001772:Blood Cell Count; D001810:Blood Volume; D003314:Corn Oil / Q000008:administration & dosage; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology; D010976:Platelet Count; D011300:Preoperative Care; D013925:Thromboplastin / Q000502:physiology
D015525:Fatty Acids, Omega-3; D003314:Corn Oil; D013925:Thromboplastin