title: The role of mechanistic studies in understanding target organ toxicity.
authors.affiliation: Research Toxicology Section, Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
authors.forename: E A
authors.initials: EA
authors.lastname: Lock
mesh_terms: D000818:Animals; D002070:Butadienes / Q000633:toxicity; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008954:Models, Biological; D009928:Organ Specificity / Q000502:physiology*; D011524:Protoporphyrins / Q000378:metabolism; D012307:Risk Factors; D014116:Toxicology / Q000379:methods*
chemical_list: D002070:Butadienes; D011524:Protoporphyrins; C001335:hexachlorobutadiene