[The antithrombotic action of a protein C activator from the venom of Agkistrodon blomhoffi ussuriensis in thrombus formation in an extracorporeal shunt in rats].
An antithrombotic action of the protein C (PC) activator from the venom of Agkistrodon blomhoffi ussuriensis on the model of platelet-dependent thrombosis in the arteriovenous shunt in rats was under investigation. Administration of the PC activator to rats resulted in a dose-dependent prolongation of the thrombus formation time, in a decrease in PC and factor V levels in blood and in APTT prolongation. There were no changes in the tissue-type plasminogen activator level and in the ADP- or epinephrine-induced platelet aggregation, but platelet adhesion to glass decreased. The possible mechanism of the antithrombotic action of the PC activator appeared to be the factor V inactivation mediated by protein C activation and the decrease in platelet adhesion.
Kogan
A E
AE
Bashkov
G V
GV
Bobruskin
I D
ID
Romanova
E P
EP
Makarov
V A
VA
Strukova
S M
SM
D017836:Agkistrodon; D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D002339:Carotid Arteries / Q000601:surgery; D002415:Cats; D002417:Cattle; D003435:Crotalid Venoms / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005165:Factor V / Q000032:analysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D007601:Jugular Veins / Q000601:surgery; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011486:Protein C / Q000032:analysis / Q000187:drug effects* / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
D003435:Crotalid Venoms; D005343:Fibrinolytic Agents; D011486:Protein C; D005165:Factor V
Antitromboticheskoe deĭstvie aktivatora proteina C iz iada Agkistrodon blomhoffi ussuriensis pri tromboobrazovanii v ékstrakorporal'nom shunte u krys.