[The effect of thrombocytes on active forms of oxygen generated by leukocytes in the blood of patients with bronchial asthma].
This study was undertaken to evaluate effects of platelets on leukocyte generated active oxygen forms (LGAOF) in blood of patients with bronchial asthma (BA). Twenty patients with BA were studied. LGAOF were studied by the method of luminol-dependent chemoluminescence (LC). The basic parameter of CL intensity and delta changes of its peak after addition of platelet enriched plasma or platelet deficient plasma has been measured. In patients in the state of deterioration it has come to decreased parameters of the platelet inhibitory activity compared with healthy volunteers when it has been observed its direct dependence on severity of the deterioration and severity of the disease. In patients in the phase of remission the parameters of platelet inhibitory activity were increased compared to the phase of deterioration, although it was for 1.5 time under normal value. In patients with BA in the phase of deterioration the protective effects of platelets are considerably reduced and LGAOF are intensified which points to the pathologic role of platelets in the oxidant-antioxidant system.
Sergej
B
B
Katedra za unutrasnje bolesti br. 2 Prvog medicinskog fakulteta i Katedra za patofiziologiju Moskovske medicinske akademije I. M. Secenov.
Grigorjevna
D I
DI
Haritonovic
K A
KA
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood*; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*
D010100:Oxygen
Uticaj trombocita na generisanje aktivnih formi kiseonika nastalih u leukocitima iz krvi kod bolesnika sa bronhijalnom astmom.