[Lipopolysaccharide-induced cellular immunity response and effect of herbal purgation method in intra-abdominal infection].
The alterations of cytokines (TNF,PGE2), plasma lipopolysaccharide and their prognostic influences in 58 patients with intra-abdominal infection were observed with ELISA and RIA. The effect on physiopathologic process with herbal purgation method was explored. The results showed that as the level of plasma LPS raised the serum TNF, plasma PGE2 elevated obviously and the cellular immunity inhibited elevated in treatment and control groups. There was a linear positive correlation between the plasma LPS and the serum TNF in control group. Between the plasma PGE2 and CD4 lymphocytes of peripheral blood, it existed a linear negative correlation in treatment group. After two treatment courses, the recovery of abnormal indexes in treatment group was earlier than that in control group accompanied by escalation of lessened toxicity rate of LPS, more rapid in reducing the level and detectable rate of serum TNF, and the lowering of complication rate successively and the inhibition of cellular immunity tended to be relieved in treatment group.
Qin
M F
MF
Dept. of Surgery, Nan Kai Hospital, Tianjin.
Wu
X Z
XZ
D000328:Adult; D000368:Aged; D002764:Cholecystitis / Q000188:drug therapy / Q000276:immunology*; D015232:Dinoprostone / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006090:Gram-Negative Bacteria; D006801:Humans; D007111:Immunity, Cellular; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000188:drug therapy / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D015232:Dinoprostone