[Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat].
Renal hypertrophy and elevated glomerular filtration rate (GFR) appeared in early stage of diabetic nephropathy (DN). In order to investigate the effect of Rheum officinale (RO) on the renal hypertrophy, streptozotocin induced diabetic rats with moderate hyperglycemia were divided into two groups, receiving RO (RO-DN) or not (DN), and one group of non-diabetic control (C) was set up. At the 28th day, DN group exhibited heavier kidney weight (+61%), more protein (+133%) and DNA (+94%) contents in the kidney and higher GFR (+94%) than the control. RO-DN rats showed much less above mentioned changes. In addition, lipid abnormalities were ameliorated in RO-DN group. This result suggest that RO is beneficial to the diabetes in terms of renal hypertrophy and GFR changes at early stage and is recommended in the treatment of diabetic nephropathy.
Yang
J W
JW
Institutes of Nephrology, Jingling Hospital, Nanjing.
Li
L S
LS
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006984:Hypertrophy; D007668:Kidney / Q000473:pathology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012250:Rheum
D004365:Drugs, Chinese Herbal