A randomized, open, comparative study of brodimoprim versus erythromycin in patients with acute tonsillitis or bronchitis.
The objective of the study was the comparison of the efficacy and tolerability of brodimoprim to those of erythromycin in children with acute tonsillitis or bronchitis. 50 children aged 0.5 to 9.3 years were included in the study, 25 treated either with brodimoprim or with erythromycin. The evaluation of the therapeutic response was based exclusively on clinical criteria. In the brodimoprim group the therapy was successful in 24 patients (one failure), in the erythromycin group the therapy was also successful in 24 children (one failure). Side effects: three patients treated with brodimoprim reported adverse reactions (stomatitis, vomiting, skin rash), whereas only one patient in the erythromycin group developed a skin rash.


CONCLUSIONS
both therapeutic regimens were equally effective against bronchitis and tonsillitis in children. The tolerability was good in both groups.
Salzberg
R
R
Kinderartz FMH, Basel, Switzerland.
D000208:Acute Disease; D001991:Bronchitis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004917:Erythromycin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D014069:Tonsillitis / Q000188:drug therapy*; D014295:Trimethoprim / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004917:Erythromycin; D014295:Trimethoprim; C037079:brodimoprim