Testicular tumor after cisplatin-based chemotherapy for germ cell malignancy.
Among 417 patients treated with cisplatin-based chemotherapy for germ cell malignancy (median follow-up 7 years) we observed 6 patients who developed a second tumor of the testis. In 3 cases the first tumor was of testicular origin, whereas in the other cases the initial tumor presented in the retroperitoneal space. Although cisplatin-based chemotherapy may reduce or delay the development of a contralateral testicular tumor, the risk apparently is not completely eliminated. Patients with primary retroperitoneal germ cell tumors need a close and careful follow-up, as they appear to be at an increased risk for developing a testicular tumor.
Gerl
A
A
Medizinische Klinik III, Klinikum Grosshadern der Universität München, BRD.
Clemm
C
C
Kohl
P
P
Wilmanns
W
W
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D012307:Risk Factors; D018239:Seminoma / Q000453:epidemiology*; D013724:Teratoma / Q000188:drug therapy* / Q000453:epidemiology; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors
D002945:Cisplatin