Membranoproliferative glomerulonephritis type II associated with central serous retinopathy.
Membranoproliferative glomerulonephritis type II is specifically associated with the presence of dense deposits in the basement membrane of Bruch's membrane, which result in lesions similar to basal laminar drusen, exudative drusen, and retinal pigment epithelial detachments. In advanced stages of this dense-deposit retinopathy, choroidal neovascularization may occur. We observed a 36-year-old patient with membranoproliferative glomerulonephritis type II who developed central serous retinopathy in the presence of specific dense-deposit-associated fundus lesions. The diffuse drusenlike dense deposits (at the level of Bruch's membrane) and associated retinal pigment epithelial detachments appear to contribute to the pathogenesis of central serous retinopathy. Thus changes in Bruch's membrane may be involved in the development of central serous retinopathy.
Ulbig
M R
MR
Retinal Diagnostic Department, Moorfields Eye Hospital, London, United Kingdom.
Riordan-Eva
P
P
Holz
F G
FG
Rees
H C
HC
Hamilton
P A
PA
D000328:Adult; D016570:Bruch Membrane / Q000473:pathology; D005122:Exudates and Transudates; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000648:ultrastructure; D008297:Male; D012163:Retinal Detachment / Q000150:complications* / Q000473:pathology; D014792:Visual Acuity