Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces.
Starch that escapes digestion in the small intestine increases the elimination of chenodeoxycholate and its metabolites in the faeces of both mice and hamsters. In contrast, the elimination of cholate and its metabolites is not increased. In vitro, the affinity of starch for chenodeoxycholate is about 90-fold greater than for cholate. beta-Cyclodextrin, which approximates to one turn of the helical structures formed by the 1,4-linked glucose units of starch, shares these properties. It is proposed that these helical structures in starch act as binding sites for bile salts.
Abadie
C
C
Pharma Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Hug
M
M
Kübli
C
C
Gains
N
N
D000818:Animals; D001665:Binding Sites; D002635:Chenodeoxycholic Acid / Q000378:metabolism*; D002792:Cholestyramine Resin / Q000378:metabolism / Q000494:pharmacology; D006224:Cricetinae; D003505:Cyclodextrins / Q000378:metabolism / Q000494:pharmacology*; D004063:Digestion; D005243:Feces; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D051379:Mice; D013213:Starch / Q000378:metabolism / Q000494:pharmacology*
D003505:Cyclodextrins; D002635:Chenodeoxycholic Acid; D002792:Cholestyramine Resin; D013213:Starch