[The effect of flumazenil administration on acute cocaine intoxication of rats].
Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex. Two minutes after the intraperitoneal injection of cocaine (70 mg/kg) into a rat, flumazenil and diazepam were administered at the clinically corresponding dose intraperitoneally. Flumazenil at a dose 0.125 mg/kg extended the onset time of the cocaine induced seizure. Flumazenil at 0.5 or 1.0 mg/kg with diazepam 2.0 mg/kg, prevented the seizure, and kept righting reflex. It was observed that use of flumazenil in combination with cocaine had the effect of the benzodiazepine receptor.
Uki
F
F
Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
Nihira
M
M
Hirakawa
K
K
Uekusa
K
K
D000208:Acute Disease; D000818:Animals; D003042:Cocaine / Q000506:poisoning*; D003975:Diazepam / Q000627:therapeutic use; D005442:Flumazenil / Q000627:therapeutic use*; D008297:Male; D011041:Poisoning / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
D005442:Flumazenil; D003042:Cocaine; D003975:Diazepam