title: Early diagnosis of breast cancer dissemination by tumor markers follow-up and method of prediction.
abstract: A mathematical model of prediction of progression was tested in patients with breast cancer employing long-term monitoring of tumor markers CEA, CA 15-3, MCA and TPA, erythrocyte sedimentation rate (FW), and the enzymes gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and lactate dehydrogenase (LD) in serum. At the same time, specificity, sensitivity, lead time and positive predictive value were evaluated along with false positivity for all these parameters and their combinations. A model was proposed for the follow-up of patients with breast cancer after the completion of basic therapy.
authors.affiliation: Masaryk Memorial Cancer Institute, Brno, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Nekulová
authors.forename: M
authors.initials: M
authors.lastname: Simícková
authors.forename: L
authors.initials: L
authors.lastname: Pecen
authors.forename: K
authors.initials: K
authors.lastname: Eben
authors.forename: I
authors.initials: I
authors.lastname: Vermousek
authors.forename: P
authors.initials: P
authors.lastname: Stratil
authors.forename: M
authors.initials: M
authors.lastname: Cernoch
authors.forename: B
authors.initials: B
authors.lastname: Lang
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000175:diagnosis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008433:Mathematics; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis; D012372:ROC Curve
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen