title: Metastatic hepatocellular carcinoma to bone in a liver transplant patient. A case report.
abstract: Although previously unreported in the orthopaedic literature, hepatocellular carcinoma metastasizes to bone in 2 to 20% of cases. The poor prognosis associated with this tumor often results in patient demise before the need for orthopaedic intervention. A liver transplant recipient with no known history of hepatocellular carcinoma was diagnosed with this tumor when open reduction and internal fixation of an impending pathologic femoral fracture were performed. Metastatic hepatocellular carcinoma should be considered in the differential diagnosis of a lytic osseous metastasis in appropriate patient populations.
authors.affiliation: Department of Orthopaedic Surgery, University of California School of Medicine, Los Angeles 90024.
authors.forename: R M
authors.initials: RM
authors.lastname: Kay
authors.forename: J J
authors.initials: JJ
authors.lastname: Eckardt
authors.forename: L I
authors.initials: LI
authors.lastname: Goldstein
authors.forename: R W
authors.initials: RW
authors.lastname: Busuttil
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D005266:Femoral Neoplasms / Q000556:secondary; D005953:Glycogen Storage Disease Type I / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D010384:Pelvic Bones