title: The analgesic effects of administering fentanyl or medetomidine in the lumbosacral epidural space of cats.
abstract: The analgesic effects of fentanyl (4 micrograms/kg) and medetomidine (10 micrograms/kg) in 1 mL saline injected epidurally were measured in 15 cats. The response to an electrical cutaneous stimulus from a constant current generator was used as the index of analgesia. The stimulus was applied to a forelimb before epidural injection, and at 15, 30, 60, 90, 120, 180, 240, and 300 minutes post-injection (PI). The hindlimb was tested 5 minutes later. One mL saline only was used to control for volume of injection and saline. Medetomidine significantly increased the pain threshold for the hindlimb at 20 to 245 minutes PI compared with the preinjection level. Fentanyl significantly increased the pain threshold at 20 minutes PI only compared with preinjection levels. Medetomidine significantly increased the pain threshold of the forelimb at 15 to 120 minutes PI compared with the preinjection levels. Fentanyl did not significantly increase the pain threshold of the forelimb. Administration of medetomidine produced emesis in 12 of 15 cats in an average of 6.4 minutes PI (range, 3 to 11 minutes) and mild sedation in all cats. Injection of fentanyl produced no visible side effects in any of the cats.
authors.affiliation: Department of Veterinary Anesthesiology, Radiology, and Surgery, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Duke
authors.forename: A M
authors.initials: AM
authors.lastname: Cox
authors.forename: A M
authors.initials: AM
authors.lastname: Remedios
authors.forename: P H
authors.initials: PH
authors.lastname: Cribb
mesh_terms: D015360:Analgesia, Epidural / Q000662:veterinary*; D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D002415:Cats / Q000502:physiology*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D007093:Imidazoles / Q000008:administration & dosage; D008297:Male; D020926:Medetomidine; D017288:Pain Threshold / Q000187:drug effects; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary; D013997:Time Factors
chemical_list: D000700:Analgesics; D007093:Imidazoles; D020926:Medetomidine; D005283:Fentanyl