[The treatment of primary biliary liver cirrhosis with rifampicin].
Seven patients with primary biliary cirrhosis were treated with rifampicin administered for 2 weeks in a daily dose 450-600 mg. Due to the treatment the itch disappeared completely in 4 and decreased significantly in 3 patients. As shown by the antipyrine test, half-life and clearance of antipyrine returned to normal suggesting cytochrome P-450 induction as a result of hydroxylation activity. There was a tendency to lowering of bilirubin, cholesterol, alkaline phosphatase, asparagine--and alanine aminotransferase against an increase in gammaglobulins. The differences were, however, insignificant. Rifampicin tolerance was satisfactory.
Loginov
A S
AS
Reshetniak
V I
VI
Petrakov
A V
AV
D000328:Adult; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D011537:Pruritus / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D012293:Rifampin / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
D012293:Rifampin
Lechenie pervichnogo biliarnogo tsirroza pecheni rifampitsinom.