[Aspects of Plasmodium falciparum sensitivity to chloroquine in Madagascar from 1982 to 1993].
According to pharmaco-sensitivity studies, about 20% of local Plasmodium falciparum strains showed a certain degree of resistance to chloroquine. No resistance of R3 type has never been observed. During this whole period, the decrease of sensitivity phenomenon remains stable. Because of its remarkable action on parasitemia and fever, chloroquine remains the best antimalaria in simple malarial attacks in madagascar.
Raharimalala
L
L
Lepers
J P
JP
Lepers-Rason
M D
MD
Rabarison
P
P
Ramambanirina
L
L
Roux
J
J
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D005334:Fever / Q000209:etiology; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000145:classification*; D011159:Population Surveillance; D012703:Serotyping
D002738:Chloroquine
Aspects de la sensibilité de Plasmodium falciparum à la chloroquine à Madagascar de 1982 à 1993.