Human bone and tissue allografts. Preparation and safety.
Currently, modern tissue banks routinely supply requested bone and soft-tissue allografts. These allografts are safe if tissue-bank personnel adhere to the existing methodology for excluding any donors with potential for disease transmission. The authors' discard rate after excision of tissues has been approximately 18%, reflecting their concern for allograft safety. The preparation of significant numbers of allografts is labor intensive and very expensive, as is multiphasic screening of donors. However, long-term success with a large number of bone or soft-tissue recipient patients has led physicians and patients to have confidence in the safety of allografts prepared as described.
Buck
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Department of Orthopaedics and Rehabilitation, University of Miami School of Medicine, FL 33101.
Malinin
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D016025:Bone Transplantation; D003238:Connective Tissue / Q000637:transplantation; D003428:Cross Infection / Q000517:prevention & control*; D015658:HIV Infections / Q000635:transmission; D006801:Humans; D009098:Multiphasic Screening; D012449:Safety; D014015:Tissue Banks; D014019:Tissue Donors; D014021:Tissue Preservation / Q000592:standards*; D014184:Transplantation, Homologous