Report of the European DNA profiling group (EDNAP)--towards standardisation of short tandem repeat (STR) loci.
This paper describes a collaborative exercise intended to demonstrate whether uniformity of DNA profiling results could be achieved between European laboratories using short tandem repeat (STR) loci. Two different STRs were chosen--HUMTH01 and the AT-rich HUMACTBP2 (SE33). The former locus has only five common alleles, whereas the latter is complex and has at least 30 alleles. Laboratories were asked to test seven blood stains and to report the results to the coordinating laboratory. The exercise demonstrated that the simple STR systems such as HUMTH01 are more amenable to adoption as standard loci than complex AT-rich systems.
Gill
P
P
Central Research and Support Establishment, Aldermaston, U.K.
Kimpton
C
C
D'Aloja
E
E
Andersen
J F
JF
Bar
W
W
Brinkmann
B
B
Holgersson
S
S
Johnsson
V
V
Kloosterman
A D
AD
Lareu
M V
MV
D000483:Alleles; D001483:Base Sequence; D001801:Blood Stains; D016172:DNA Fingerprinting / Q000592:standards*; D005060:Europe; D005784:Gene Amplification; D006801:Humans; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid