title: [The antiarrhythmic activity of the polymeric forms of quinidine, trimecaine, etatsizin, propranolol and verapamil].
abstract: The antiarrhythmic activity and acute toxicity of polymeric formulations of quinidine, trimecaine, ethacizine, propranolol, verapamil which had been immobilized on a cellulose carrier (monocarboxylcellulose) and low molecular analogues were studied in various experimental animals (rats, mice, dogs). The polymeric formulations of trimecaine and verapamil were found to have a higher antiarrhythmic activity in different arrhythmia models than trimecaine and verapamil. The toxicity of all new compounds was no more than the values of conventional antiarrhythmic drugs.
authors.forename: G I
authors.initials: GI
authors.lastname: Sidorenko
authors.forename: A V
authors.initials: AV
authors.lastname: Gurin
authors.forename: M G
authors.initials: MG
authors.lastname: Koliadko
authors.forename: T L
authors.initials: TL
authors.lastname: Iurkshtovich
authors.forename: V L
authors.initials: VL
authors.lastname: Nedorezov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000401:mortality; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D010640:Phenothiazines / Q000627:therapeutic use* / Q000633:toxicity; D011108:Polymers; D011433:Propranolol / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D011802:Quinidine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D014288:Trimecaine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D014700:Verapamil / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D011108:Polymers; D011433:Propranolol; D014700:Verapamil; C046818:ethacizine; D014288:Trimecaine; D011802:Quinidine
vernacular_title: Antiaritmicheskaia aktivnost' polimernykh form khinidina, trimekaina, étatsizina, propranolola i verapamila.