title: [Efficacy of lidocaine cardioplegia for spontaneous resumption of heart beating].
abstract: Efficacy of lidocaine for cardiac rhythms after aortic declamping was evaluated retrospectively. Twenty-four patients undergoing coronary artery bypass grafting (CABG) (Group C1) and seven patients undergoing aortic or mitral valve replacement (VR) (Group V1) received crystalloid cardioplegia without lidocaine, while 21 patients undergoing CABG (Group C2) and 19 patients undergoing VR (Group V2) received lidocaine (50 mg/l) added crystalloid cardioplegia. After aortic declamping, there was a significant increase in spontaneous resumption of heart beating in Group C2 (71.4%) and Group V2 (57.9%), as compared with their respective counterparts, Group C1 (4.2%) and Group V1 (0%). Mean attempts of electrical defibrillation were significantly decreased in Group C2 (one time) and Group V2 (1.33 times), while electrical defibrillation was required 1.74 times in Group C1 and 2.71 times in Group V1. The present study suggests that lidocaine cardioplegia increases spontaneous defibrillation and decreases the need of electrical defibrillation.
authors.affiliation: Department of Cardiac Surgery, Asahi General Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Saitoh
authors.forename: A
authors.initials: A
authors.lastname: Mizuno
mesh_terms: D000328:Adult; D000368:Aged; D002314:Cardioplegic Solutions / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D005260:Female; D006324:Heart Arrest, Induced; D006331:Heart Diseases / Q000503:physiopathology / Q000601:surgery; D006339:Heart Rate / Q000187:drug effects*; D006350:Heart Valve Prosthesis; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017680:Potassium Compounds / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D002314:Cardioplegic Solutions; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D008012:Lidocaine