title: Nylestriol replacement therapy in postmenopausal women. A three-year prospective study.
abstract: A three-year prospective study was carried out in 283 postmenopausal women to evaluate the effects of a long-acting estriol derivative-nylestriol. The women were randomly assigned into 3 groups: group A (136 cases, nylestriol 2 mg/2 wk), group B (97, nylestriol 1 mg/2 wk) and group C (50, placebo/2wk). LDL-C decreased and HDL-C increased after 3 months of medication (P < 0.05), but TC and TG not significantly changed in any group (P > 0.05). No changes of lipids were found in group C (P > 0.05). Serum ALP, Ca/Cr and Hpr/Cr in fasting urine decreased in 3 months in both group A and B (P < 0.05), but not in group C (P > 0.05). Forearm bone mineral content loss was restrained in groups A and B (P > 0.05), but decreased markedly in group C (P < 0.01). The Kupperman index scores decreased by about 50% after 3 months and 80% in 12 months in groups A and B. Nylestriol induced mild stimulatory effect on the uterine endometrium, and addition of 6 mg of provera daily for 7-10 days every 6 months is recommended. Nylestriol exhibited no obvious effect on the breast. This study demonstrated that nylestriol can be used as an effective and acceptable estrogen replacement therapy for postmenopausal women.
authors.affiliation: Department of Obstetrics and Gynecology, Chinese Great Wall Hospital, Beijing.
authors.forename: G J
authors.initials: GJ
authors.lastname: Cheng
authors.forename: J L
authors.initials: JL
authors.lastname: Liu
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: H F
authors.initials: HF
authors.lastname: Ye
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Wang
authors.forename: H P
authors.initials: HP
authors.lastname: Pan
mesh_terms: D000368:Aged; D015519:Bone Density; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C010722:nylestriol; D011800:Quinestrol