Comparative in vitro diffusion studies for atenolol transdermal delivery system.
The purpose of this study was to screen atenolol as a candidate for transdermal drug delivery, and to study the release of atenolol from various gels. The percent atenolol release over time profiles indicates that for all the gelling agents used the amount of atenolol released is decreased by increasing the polymer concentration in the gel. The amount of atenolol released was found to be higher from Klucel gels, compared to Methocel and Carbopol gels, with Carbopol gels giving the least release. In studying the effect of atenolol concentration in the gel, it was observed that the amount of atenolol released was increased by increasing the drug concentration in the donor up to a limit corresponding to an atenolol concentration of approximately 2%. This seems to resemble the saturation solubility of atenolol into the gels. Hairless mouse skin and TESTSKIN LSE were used as in vitro skin models.
Demou
J S
JS
Division of Pharmaceutics and Industrial Pharmacy, Arnold and Marie Shwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201.
Sidhom
M B
MB
Plakogiannis
F M
FM
D000279:Administration, Cutaneous; D000818:Animals; D001262:Atenolol / Q000008:administration & dosage*; D004058:Diffusion; D016503:Drug Delivery Systems; D008297:Male; D051379:Mice; D008812:Mice, Hairless
D001262:Atenolol