title: A tumour-associated antigen expression in human haematological malignancies.
abstract: Objective responses obtained with high-dose in vivo recombinant interleukin 2 (r-IL2) in some leukaemic patients suggest among other hypotheses that blasts might express tumour rejection antigens potentially recognized by cytolytic T lymphocytes. Such antigens have been described in human melanomas and the MAGE-1 gene, coding for a tumour rejection antigen was recently identified. This gene is expressed in various solid tumours, but not in normal cells. We have screened a panel of haematological malignancies by reverse transcription and PCR and we report that MAGE-1 is not expressed in the blasts from 48 patients whereas three cell lines derived from leukaemias express this gene.
authors.affiliation: INSERM U119, Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Chambost
authors.forename: F
authors.initials: F
authors.lastname: Brasseur
authors.forename: P
authors.initials: P
authors.lastname: Coulie
authors.forename: E
authors.initials: E
authors.lastname: de Plaen
authors.forename: A M
authors.initials: AM
authors.lastname: Stoppa
authors.forename: D
authors.initials: D
authors.lastname: Baume
authors.forename: P
authors.initials: P
authors.lastname: Mannoni
authors.forename: T
authors.initials: T
authors.lastname: Boon
authors.forename: D
authors.initials: D
authors.lastname: Maraninchi
authors.forename: D
authors.initials: D
authors.lastname: Olive
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology; D058950:Melanoma-Specific Antigens; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D012333:RNA, Messenger