title: Methotrexate serum binding in rheumatoid arthritis.
abstract: The serum binding of methotrexate was determined by equilibrium dialysis using radiolabelled methotrexate. Methotrexate was only albumin-bound in serum. The binding was 46% in controls versus 42% in rheumatoid arthritis and 44% in cancer. Serum binding was significantly decreased by salicylate and high concentration of naproxen. Hypoalbuminemia and concomitant administration of salicylate or naproxen may influence methotrexate toxicity.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Créteil, Université Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Claudepierre
authors.forename: S
authors.initials: S
authors.lastname: Urien
authors.forename: X
authors.initials: X
authors.lastname: Chevalier
authors.forename: O
authors.initials: O
authors.lastname: Chassany
authors.forename: B
authors.initials: B
authors.lastname: Larget-Piet
authors.forename: J P
authors.initials: JP
authors.lastname: Tillement
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D003956:Dialysis; D006801:Humans; D008727:Methotrexate / Q000378:metabolism*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D014316:Tritium
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D014316:Tritium; D008727:Methotrexate