Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice.
Mice lethally infected with Candida albicans were exposed to small-particle aerosols containing amphotericin B-liposomes. The drug, when administered twice daily for 2 h (0.58 mg/kg of body weight per day) on days 1, 2, and 3 postinoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given 2 2-h treatments once a week for 4 weeks. A twice-weekly, 2-h small-particle aerosol administration of amphotericin B-liposomes for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.
Gilbert
B E
BE
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030.
Wyde
P R
PR
Lopez-Berestein
G
G
Wilson
S Z
SZ
D000281:Administration, Intranasal; D000336:Aerosols; D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004337:Drug Carriers; D005260:Female; D007668:Kidney / Q000382:microbiology; D008081:Liposomes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010316:Particle Size; D013154:Spleen / Q000382:microbiology
D000336:Aerosols; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B