[The characteristics of the immune status of patients with chronic obstructive bronchitis in PiM phenotypic variants of the alpha 1-proteinase inhibitor].
The connection between alpha 1-proteinase inhibitor variants and immunity disorders in patients with chronic obstructive bronchitis is considered in the article. As a result of investigation disorders of both T- and B-immunity systems were found. They consisted in decrease of the content and proliferative activity of T-lymphocytes, changes in their populational composition, dysfunction of B-lymphocytes, dysimmunoglobulinemia. These changes were more pronounced in allele M3+ carriers constituting the risk group on chronic lung diseases.
Chernushenko
E F
EF
Serdiuk
T M
TM
D000328:Adult; D000483:Alleles; D001402:B-Lymphocytes / Q000276:immunology; D001991:Bronchitis / Q000235:genetics / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006579:Heterozygote; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics; D008297:Male; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D000515:alpha 1-Antitrypsin
Osobennosti immunnogo statusa bol'nykh khronicheskim obstruktivnym bronkhitom pri PiM fenotipicheskikh variantakh al'fa 1-ingibitora proteinaz.