Effect of benidipine hydrochloride on regional blood flow of the adipose tissue in anesthetized rats.
The dihydropyridine calcium antagonist benidipine hydrochloride (benidipine, KW-3049, CAS 105979-17-7) was intravenously administered to rats under anesthesia with urethane to investigate the effect on regional blood flow in the brown adipose tissue. Benidipine was given at the dose of 100 or 300 micrograms/kg and regional blood flow was measured by the microsphere method. Blood flow in the brown adipose tissue significantly increased and vascular resistance significantly decreased 30 min after i.v. administration of benidipine at 100 or 300 micrograms/kg. The mean blood pressure significantly decreased in the benidipine 100 and 300 micrograms/kg groups and cardiac output significantly increased in the benidipine 300 micrograms/kg group. As i.v. administration of benidipine induced a significant increase of regional blood flow in the brown adipose tissue which consumes excess energy, this agent is expected to have anti-obesity effect in obese animals.
Kajita
J
J
Pharmaceutical Research Labortories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Kobayashi
S
S
Yoshida
T
T
D000273:Adipose Tissue / Q000098:blood supply* / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D004095:Dihydropyridines / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C061004:benidipine