[Neoformation of intestinal mucosa on dura mater patches. Application in the surgical treatment of short bowel syndrome. Experimental study in rats].
The creation of intestinal neomucosa on grafts or materials implanted in the intestinal wall is one of the therapeutic procedures that has been tested in the short bowel syndrome. This paper presents the results obtained after intestinal implanting lyophilised dural patches in an experimental model of massive intestinal resection in rats. Data were contrasted with those of a control group subjected to massive resection without patches. The findings reveal: 1) high mortality related to the surgical technique; 2) slight improvement in the ponderal curve; 3) slowing down of intestinal transit; 4) neomucosa on the patch, with histological characteristic similar to normal. We conclude that although the creation of neomucosa on dural patches is feasible and conditions a slight improvement in the animal's nutritive status, application of the procedure is not practical in treatment for the short bowel syndrome due to the high mortality rate.
Hernández Bermejo
J P
JP
Laboratorio de Cirugía Experimental, Hospital Torrecárdenas, Almería.
Aguayo Albasini
J L
JL
Moreno Egea
A
A
Martínez García
P L
PL
Zambudio Carmona
G
G
Parrilla Paricio
P
P
D000818:Animals; D001835:Body Weight; D003094:Collagen; D005260:Female; D006984:Hypertrophy; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012778:Short Bowel Syndrome / Q000601:surgery*
C032281:Lyodura; D003094:Collagen
Neoformación de mucosa intestinal sobre parches de duramadre. Aplicación en el tratamiento quirúrgico del síndrome de intestino corto. Estudio experimental en ratas.