title: In vitro postantibiotic effect following repeated exposure to imipenem, temafloxacin, and tobramycin.
abstract: The postantibiotic effect (PAE) following three consecutive 2-h exposures to imipenem, temafloxacin, and tobramycin was determined in Pseudomonas aeruginosa. A PAE and a bactericidal effect were consistently observed for imipenem following each cycle of drug exposure and regrowth. In contrast, the PAE increased with repeated exposure with temafloxacin (1.8 to > 5 h), but disappeared with tobramycin by the third exposure (0.9 to 0 h). These data show that the in vitro PAE may change within a strain following multiple cycles of drug exposure and bacterial regrowth.
authors.affiliation: Antiinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy, Roger Williams Medical Center, Providence 02908.
authors.forename: B J
authors.initials: BJ
authors.lastname: McGrath
authors.forename: C R
authors.initials: CR
authors.lastname: Marchbanks
authors.forename: D
authors.initials: D
authors.lastname: Gilbert
authors.forename: M N
authors.initials: MN
authors.lastname: Dudley
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*; D013997:Time Factors; D014031:Tobramycin / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C054745:temafloxacin; D015378:Imipenem; D014031:Tobramycin