The thiourea insecticide diafenthiuron inhibits mitochondrial ATPase in vitro and in vivo by its carbodiimide product.
Ruder
F
F
Ciba-Geigy Ltd, Business Unit Insect Control, Basel, Switzerland.
Kayser
H
H
D000818:Animals; D002234:Carbodiimides / Q000633:toxicity*; D004024:Dicyclohexylcarbodiimide / Q000633:toxicity; D007313:Insecta; D007306:Insecticides / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008931:Mitochondria, Muscle / Q000201:enzymology; D010670:Phenylthiourea / Q000031:analogs & derivatives* / Q000633:toxicity; D011355:Prodrugs / Q000633:toxicity*; D006180:Proton-Translocating ATPases / Q000037:antagonists & inhibitors*
D002234:Carbodiimides; D007306:Insecticides; D011355:Prodrugs; C087660:CGA 140408; C087661:diafenthiuron; D004024:Dicyclohexylcarbodiimide; D010670:Phenylthiourea; D006180:Proton-Translocating ATPases