HMG box proteins in early T-cell differentiation.
The central theme of this review is the molecular basis for commitment of cells to the T-cell lineage. Principles of transcriptional regulation are illustrated by two examples; the role of GATA-1 during erythroid differentiation and the function of MyoD-like proteins in myogenesis. Several regulatory proteins have been described in the T-cell lineage. Here, we focus attention on the HMG box family of DNA binding proteins. This recently defined family can be divided in two subfamilies: the HMG/UBF and the TCF/SOX group. The first group contains at least two HMG boxes and binds DNA non-specifically, while the other group of proteins has one HMG box and interacts with DNA sequence-specifically. Characteristics of the most prominent members of both subfamilies will be discussed. In particular, we will address the role of HMG box proteins in controlling the expression of T-cell specific proteins during differentiation.
Oosterwegel
M
M
Department of Immunology, University Hospital Utrecht, The Netherlands.
van de Wetering
M
M
Clevers
H
H
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000145:classification / Q000378:metabolism*; D005786:Gene Expression Regulation; D006609:High Mobility Group Proteins / Q000145:classification / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000502:physiology*
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins