RNA recognition by the human immunodeficiency virus Tat and Rev proteins.
The human immunodeficiency virus (HIV-1) regulatory proteins, Tat and Rev, are important potential targets for the development of new drug therapies against HIV infection. Both proteins are highly specific RNA-binding proteins that recognize cis-acting regulatory elements in the viral mRNAs. These interactions are fascinating paradigms of a new principle of RNA recognition in which the protein makes contact with functional groups displayed in a distorted major groove of an RNA duplex.
Gait
M J
MJ
MRC Laboratory of Molecular Biology, Cambridge, UK.
Karn
J
J
D001483:Base Sequence; D015757:Genes, rev / Q000235:genetics*; D015756:Genes, tat / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics*; D016601:RNA-Binding Proteins
D012367:RNA, Viral; D016601:RNA-Binding Proteins