[Multiple gene alterations in human esophageal squamous cell carcinoma].
In 45 human esophageal squamous cell carcinomas, 29 showed alterations of EGFr, c-myc, int-2, Rb and p53 gene by Southern blot hybridization, a frequency of 15.6%, 31.1%, 35.6%, 22.2%, 6.7%, respectively. Among these cases, 16 cases showed two or multiple gene changes, and most of them were of II-III stage. The results suggest that gene alterations may be related to pathological stages of the disease. The poorer the differentiation of the tumor, the more gene changes were accumulated. We did not find association between the presence of metastasis in lymph nodes and the gene alterations.
Liang
Y Y
YY
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D017353:Gene Deletion; D016161:Genes, Retinoblastoma; D016259:Genes, myc; D016158:Genes, p53; D006801:Humans; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D009367:Neoplasm Staging; D009857:Oncogenes