High dietary carbohydrate and pancreatic lesion.
The ability of high dietary carbohydrate to induce acute pancreatitis was investigated in groups of 16, 21-day and 15-month old rats fed different carbohydrate diets for 30 days. Significantly increased levels of serum amylase (2-fold), phospholipids (50%), phosphorus (2-fold), and lipoperoxides (8-fold) were observed in 15-month old rats fed a high-carbohydrate diet, compared to rats fed a diet with normal carbohydrate levels, indicating peroxidation of membrane lipids which caused final cell death and pancreatic lesion. Serum Cu-Zn superoxide dismutase activity was not altered. Daily administration of bovine Cu-Zn superoxide dismutase conjugated with polyethylene glycol prevented the serum level alterations and pancreatic lesions, indicating that the superoxide radical has a role in dietary carbohydrate-induced acute pancreatitis. No biochemical changes were observed in rats in which treatment was initiated on the 21st day of life indicating that this is an age-related lesion.
Novelli
E L
EL
Departamento de Química, Universidade Estadual Paulista, Botucatu, SP, Brasil.
Rodrigues
N L
NL
França
E L
EL
Gebra
L M
LM
Ribas
B O
BO
D000208:Acute Disease; D000367:Age Factors; D000818:Animals; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D010195:Pancreatitis / Q000188:drug therapy / Q000209:etiology*; D011092:Polyethylene Glycols / Q000627:therapeutic use; D051381:Rats; D013482:Superoxide Dismutase / Q000627:therapeutic use
D004040:Dietary Carbohydrates; D011092:Polyethylene Glycols; D013482:Superoxide Dismutase