[Clinical significance of the determination of several hemostatic parameters in the lacrimal fluid of patients with vascular diseases of the retina].
Clinicolaboratory studies of 92 patients with vascular diseases of the retina (retinal vein thrombosis, central chorioretinal dystrophy, retinal hypertensive angiosclerosis) were carried out to assess hemorheologic parameters (platelet and red cell aggregation coefficients, blood viscosity). In parallel with this, lacrimal fluid was analyzed for hemostatic parameters, plasminogen and antithrombin III. A marked increase of plasminogen and antithrombin III levels was found in the lacrimal fluid of patients with retinal vein thrombosis, this increase correlating with pathologic shifts in the studied rheologic characteristics. Central chorioretinal dystrophy and retinal hypertensive angiosclerosis were associated with shifts in some rheologic characteristics. Hence, measurements of lacrimal fluid hemostatic parameters plasminogen and antithrombin III in patients with retinal vascular diseases help assess blood rheology.
Mukha
A I
AI
Markova
O A
OA
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis*; D012162:Retinal Degeneration / Q000175:diagnosis; D012164:Retinal Diseases / Q000097:blood / Q000175:diagnosis; D012170:Retinal Vein Occlusion / Q000175:diagnosis; D012171:Retinal Vessels; D013666:Tears / Q000737:chemistry*
D000990:Antithrombin III; D010958:Plasminogen
O klinicheskom znachenii opredeleniia nekotorykh gemostaticheskikh pokazateleĭ v sleznoĭ zhidkosti bol'nykh s sosudistymi zabolevaniiami setchatki.