Re-evaluation of cerebrospinal fluid angiotensin-converting enzyme activity in patients with 'probable' Alzheimer's disease.
Angiotensin-converting enzyme activity was measured in lumbar cerebrospinal fluid from patients with 'probable' Alzheimer's disease (n = 17) and age-matched controls (n = 19), using a spectrofluorimetric method. In contrast to a previous finding, no statistically significant difference in the mean (specific) angiotensin-converting enzyme activity was found between the two groups. No correlation existed between (specific) enzyme activity and severity of dementia in the Alzheimer's disease patients. We conclude that angiotensin-converting enzyme in cerebrospinal fluid does not appear to be useful as a potential antemortem marker for Alzheimer's disease.
Konings
C H
CH
Department of Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.
Kuiper
M A
MA
Scheltens
P
P
Grijpma
A M
AM
van Pelt
W
W
Wolters
E C
EC
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000134:cerebrospinal fluid*; D013050:Spectrometry, Fluorescence
D007703:Peptidyl-Dipeptidase A