title: Prevention of sudden cardiac death by the atypical neuroleptic acepromazine following status epilepticus in rats.
abstract: Normal male rats in which status epilepticus has been induced by injecting 30 mg/kg of pilocarpine after a single systemic administration of lithium (sufficient to produce blood levels of 0.2 mEq/L) invariably die within 24 hr. Real-time monitoring indicated sudden cardiac death; it was preceded by progressive intensification of arrhythmia. A single systemic injection (25 mg/kg) of the atypical phenothiazine acepromazine prevented the mortality and virtually eliminated the cardiac instability.
authors.affiliation: Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, Ontario.
authors.forename: T
authors.initials: T
authors.lastname: Harrigan
authors.forename: Y R
authors.initials: YR
authors.lastname: Bureau
authors.forename: M A
authors.initials: MA
authors.lastname: Persinger
authors.forename: G H
authors.initials: GH
authors.lastname: Parker
mesh_terms: D000075:Acepromazine / Q000627:therapeutic use*; D000818:Animals; D003645:Death, Sudden; D004562:Electrocardiography; D006339:Heart Rate; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000502:physiology; D013226:Status Epilepticus / Q000150:complications*
chemical_list: D017447:Receptors, Dopamine D1; D000075:Acepromazine