A search for new active amino acids responsible for pharmacological activity of collagen degradation products.
The pharmacological activity of glycine (Gly), proline (Pro) and hydroxyproline (Hyp)--the main amino acids in collagen degradation products--was studied in comparison to the activity of all mixture of DPTC (degradation products of trihelical collagen). The investigated amino acids decreased psychomotor activity of rats, enhanced apomorphine- and amphetamine-induced stereotypy. Pro and Hyp enhanced also catalepsy, but Gly decreased the haloperidol action. Each amino acid was given adequately to its contents in DPTC. Our results indicated that hydroxyproline revealed the action on the central nervous system (CNS) in each aspect most similar to the action of DPTC mixture.
Lutostańska
A
A
Department of Pharmacology, Medical Academy, Białystok, Poland.
Telejko
E
E
Maćkowiak
J
J
Wiśniewski
K
K
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal; D002375:Catalepsy / Q000139:chemically induced; D002490:Central Nervous System / Q000187:drug effects*; D003094:Collagen / Q000378:metabolism*; D005998:Glycine / Q000494:pharmacology*; D006909:Hydroxyproline / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology; D011392:Proline / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects
D010446:Peptide Fragments; D003094:Collagen; D011392:Proline; D001058:Apomorphine; D006909:Hydroxyproline; D005998:Glycine