[The use of intravenous 7S immunoglobulins at high doses in HIV-related immunological pathology].
24 AIDS patients, both males and females, aged from 3 to 52 years, received high-dose i.v. 7S immunoglobulin (220-400 mg/kg, range 7.5-20 g/die). These patients were affected by HIV-related thrombocytopenia and antibiotic-resistant severe hyperpyrexia; three HIV-positive asymptomatic children with severe immunodeficiency were treated to prevent opportunistic infections. I.V. 7S immunoglobulins were well tolerated, and were found to be very effective in the therapy of thrombocytopenia and in the prevention of opportunistic infections in the asymptomatic children.
Fiori
G P
GP
Divisione di Malattie Infettive, Ospedale Multizonale di Varese.
D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D005334:Fever / Q000209:etiology / Q000628:therapy*; D015658:HIV Infections / Q000150:complications / Q000628:therapy*; D006679:HIV Seropositivity / Q000628:therapy; D015497:HIV-1; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*
D016756:Immunoglobulins, Intravenous
Impiego di immunoglobuline 7S per via endovenosa ad alte dosi nella patologia immunologica HIV-correlata.