[Delayed hypersensitivity after anthrax vaccination. I--Study of guinea pigs vaccinated against anthrax].
To evaluate delayed hypersensitivity after anthrax vaccination, an Anthraxin skin test was performed in 682 guinea pigs at various times after immunization with veterinary unencapsulated active anthrax vaccine. Results were compared with those obtained in unimmunized control guinea pigs (n = 216), in guinea pigs that received a non-immunizing dose of live vaccine (n = 183) and in guinea pigs inoculated with inactivated vaccine (n = 120). Anthraxin skin tests were positive in the first postvaccination days. The incidence and intensity of positive tests peaked between two weeks and one month after vaccination and then gradually decreased during the first year. Study of resistance of guinea pigs to an inoculum at a lethal dose of a virulent strain of Bacillus anthracis showed a close correlation between positive tests and resistance. These findings demonstrate development of cell-mediated immunity after anthrax vaccination. The Anthraxin skin test should have practical applications for the production of vaccines and for evaluation of the immune status of vaccinated livestock [corrected].
Shlyakhov
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E
Unité des Maladies Infectieuses, Centre médical Sheba, Université de Tel Aviv, Israel.
Rubinstein
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E
D000818:Animals; D000881:Anthrax / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology*; D007111:Immunity, Cellular; D015994:Incidence; D008297:Male; D012882:Skin Tests; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000009:adverse effects
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated
Hypersensibilité retardée charbonneuse post-vaccinale. I--Etude chez des cobayes vaccinés contre le charbon.