[Asthma induced by aspirin and arachidonic acid metabolites. I. In search of answers to an enigma (first part)].
Acetylsalicylic acid, one of the most commonly used drugs and high on the list of causes of drug reactions. Since early publication on 1902 by Hirschberg, a great deal of information has emerged on aspirin sensitivity, including data on epidemiology, further characterization of the two major subtypes of sensitivity (bronchospastic and urticarial types), hereditary aspects, cross-reactions to other nonsteroidal antiinflammatory drugs, and methods of desensitization. Although the pathogenesis of aspirin-sensitive asthma remains unknown, several theories has been proposed to explain the disease enigma.
Salazar Villa
R M
RM
Div. Allergy & Immunology, Scripps Clinic & Research Foundation, La Jolla, CA.
Zambrano Villa
S
S
D016718:Arachidonic Acid / Q000009:adverse effects* / Q000378:metabolism*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D006801:Humans
D016718:Arachidonic Acid; D001241:Aspirin
Asma inducida por aspirina y metabolitos del ácido araquidónico. I. En busca de respuestas a un enigma (primera parte).