Immune response in cattle induced by inactivated rabies vaccine adjuvanted with aluminium hydroxide either alone or in combination with avridine.
In a comparative study of two commercial baby hamster kidney rabies vaccines produced in Brazil, the authors were able to demonstrate the following: a) both vaccines provoked a high level of antibody response and protection against challenge in cattle b) in primary vaccination, at least, the addition of avridine (a synthetic lipoidal amine) enhances the immune response in terms of the level and persistence of antibody c) over 90% of cattle vaccinated with either vaccine were protected against experimental challenge one year after revaccination, and the antibody response profile indicated that these vaccines were capable of maintaining antibody titres above protective levels for more than two years after revaccination. On the basis of these results, the authors recommend optional revaccination of young animals (i.e. "primo-vaccinates") at six months of age. Thereafter, annual revaccination should be sufficient to ensure high levels of antibody between vaccination cycles.
Côrtes
J A
JA
Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil.
Rweyemamu
M M
MM
Ito
F H
FH
Umehara
O
O
Medeiros Neto
R R
RR
De Lucca-Neto
D
D
Baltazar
M C
MC
Vasconcellos
S A
SA
Vasconcellos
M E
ME
D000276:Adjuvants, Immunologic; D000536:Aluminum Hydroxide; D000704:Analysis of Variance; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control; D003959:Diamines; D005260:Female; D007117:Immunization, Secondary / Q000662:veterinary; D007369:Interferon Inducers; D051379:Mice; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000276:immunology
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D003959:Diamines; D007369:Interferon Inducers; D011819:Rabies Vaccines; D015164:Vaccines, Inactivated; D000536:Aluminum Hydroxide; C006270:avridine