Late sequelae in children treated for brain tumors and leukemia.
Forty-two survivors treated at an age of 2-16 years for brain tumors or leukemia were, 4-21 years after treatment, subjected to an extensive follow-up investigation, including physical examination and interview; 35 of them also had endocrinological and 33 psychological evaluation. Hormonal deficiencies were found in about two-thirds of patients and were most common in those treated for brain tumors. The great majority had verbal intelligence quotient (VIQ) within normal range. Also, the performance intelligence quotients (PIQ) were normal in most patients. However, the results suggested that the primary intellectual capacity in children treated for cancer was not being fully utilized, their PIQ being on the average higher than their VIQ; this tendency was especially pronounced in the leukemia patients.
Jereb
B
B
Institute of Oncology, Ljubljana, Slovenia.
Korenjak
R
R
Krzisnik
C
C
Petric-Grabnar
G
G
Zadravec-Zaletel
L
L
Anzic
J
J
Stare
J
J
D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000209:etiology; D001254:Astrocytoma / Q000532:radiotherapy; D001921:Brain / Q000528:radiation effects; D001925:Brain Damage, Chronic / Q000209:etiology*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects*; D004806:Ependymoma / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D018237:Germinoma / Q000532:radiotherapy; D006801:Humans; D007360:Intelligence / Q000528:radiation effects*; D007938:Leukemia / Q000188:drug therapy / Q000532:radiotherapy*; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D010902:Pituitary Gland / Q000528:radiation effects; D010907:Pituitary Hormones / Q000172:deficiency; D011581:Psychological Tests; D011597:Psychomotor Performance / Q000528:radiation effects; D011795:Surveys and Questionnaires; D017741:Survivors; D013961:Thyroid Gland / Q000528:radiation effects*; D013963:Thyroid Hormones / Q000172:deficiency; D014705:Verbal Behavior / Q000528:radiation effects
D010907:Pituitary Hormones; D013963:Thyroid Hormones