Gonadectomy abrogates sex differences in the effectiveness of chemical carcinogenesis in mice.
Sham-gonadectomized and gonadectomized male and female mice were given methylcholanthrene s.c. to assess the influence of sex hormones on carcinogenesis. Gonadectomy decreased the concentration of the respective sex hormone and increased the concentration of the opposite sex hormone. The results showed that androgens enhanced the effectiveness of carcinogenesis, while estrogens had the opposite effect. Gonadectomy effectively abrogated the sex differences in tumor induction.
Somogyi
L
L
Department of Physiology, School of Medicine, University of Zagreb, Sestre Milosrdnice University Hospital, Croatia.
Jukić
T
T
Bukovec
Z
Z
Culo
F
F
Marusić
M
M
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000097:blood; D005260:Female; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D012727:Sex Characteristics; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D004958:Estradiol; D008748:Methylcholanthrene