Steroid-free immunosuppression after renal transplantation.
Concerns about the side effects of chronic steroid therapy have prompted increasing interest in steroid-free immunosuppression for renal transplant recipients who are maintained on cyclosporine-based regimens. Studies to date suggest that at least 50% of cyclosporine-treated patients can be managed without steroid therapy. Reported benefits of avoiding or withdrawing steroid therapy have included improvements in hyperlipidemia, hypertension, and glucose intolerance and accelerated growth in children. Whether these effects will increase patient or allograft survival remains to be proved. Furthermore, the benefits of steroid-free immunosuppression must be weighed against the risk of precipitating allograft rejection. Although the elimination of steroids clearly increases the short-term risk of acute rejection, further studies are needed to determine the effects of steroid-free immunosuppression on long-term allograft function and to identify clinical or immunologic factors that can predict a successful outcome after the elimination of steroids.
Hricik
D E
DE
Department of Medicine, Case Western Reserve University, Cleveland, OH.
Kupin
W L
WL
First
M R
MR
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D016572:Cyclosporine / Q000008:administration & dosage; D006084:Graft Rejection / Q000209:etiology; D006128:Growth / Q000187:drug effects; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation / Q000276:immunology* / Q000502:physiology; D008055:Lipids / Q000097:blood
D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D008055:Lipids; D016572:Cyclosporine