title: Adjuvant progestagen therapy improves survival in patients with endometrial cancer after hysterectomy. Results of one-institutional prospective clinical trial.
abstract: A prospective study was conducted to determine the effectiveness of adjuvant hormonotherapy in endometrial cancer after surgery. Two hundred and five patients were randomly assigned to adjuvant progestagen treatment or were given no additional therapy. The follow-up was 5-years. We concluded that there was evidence of gain from adjuvant progestagen therapy in postoperative endometrial cancer. The group of patients who received progestagens had significantly longer survival than the control group without hormonotherapy (Logrank test; P < 0.001).
authors.affiliation: Department of Gynaecological Oncology, Maria Skłodowska-Curie Memorial, Cancer Center and Institute of Oncology, Cracow, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Urbański
authors.forename: K
authors.initials: K
authors.lastname: Karolewski
authors.forename: Z
authors.initials: Z
authors.lastname: Kojs
authors.forename: M
authors.initials: M
authors.lastname: Klimek
authors.forename: T
authors.initials: T
authors.lastname: Dyba
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D007044:Hysterectomy; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011867:Radioisotope Teletherapy; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate