Present status and perspectives of boron neutron capture therapy.
Boron neutron capture therapy (BNCT) is a mode of radiotherapy with great attractiveness, but also with a burden of past failure. In this review, the principles of BNCT, the reasons for its past failure, its present clinical application, and the on-going developmental work towards clinical trials are described.
Gabel
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Department of Chemistry, University of Bremen, Germany.
D000818:Animals; D001894:Borohydrides / Q000008:administration & dosage / Q000627:therapeutic use; D001895:Boron / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy / Q000009:adverse effects / Q000379:methods / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D013438:Sulfhydryl Compounds / Q000008:administration & dosage / Q000627:therapeutic use
D001894:Borohydrides; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D001895:Boron