Potassium, rubidium, and 4-aminopyridine effects on the circadian running rhythm in the hamster.
The period of the circadian rhythm of wheel-running was shortened when golden hamsters were given supplemental dietary potassium or rubidium for two weeks. Treatment with 4-aminopyridine, a potassium channel blocker, significantly increased circadian period. These period changes (0.17 h for potassium treatment, 0.14 h for rubidium, and 0.07 h for 4-aminopyridine) support previous data indicating that potassium is a component of the mammalian biological clock mechanism.
Klemfuss
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Veterans Affairs Medical Center, San Diego, CA 92161.
Kripke
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DF
D015761:4-Aminopyridine / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009043:Motor Activity / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D017419:Potassium, Dietary / Q000494:pharmacology*; D012413:Rubidium / Q000494:pharmacology*
D017419:Potassium, Dietary; D015761:4-Aminopyridine; D012413:Rubidium; D011188:Potassium