Fluconazol plus ofloxacin in prophylaxis of infections in patients with acute leukemia: a comparative study.
In a retrospective study the incidence of infections, number of afebrile days, duration of antimicrobial chemotherapy, and cost of antibacterials and antimycotics were compared in two groups of patients. One was a group of 57 patients who received no prophylaxis during induction remission therapy of acute leukemia treated in 1989-1990, the second was a group of 22 patients treated in 1991 where prophylaxis with fluconazol and ofloxacin was administered. For ethical reasons pertaining since 1991, when prophylaxis became mandatory, the study was not randomized. A decrease in the number of febrile days, the cost of antimicrobials and the duration of treatment with antibiotics and antimycotics was observed in the group receiving fluconazol and ofloxacin.
Sajben
P
P
National Cancer Institute, Bratislava, Slovakia.
Minárik
T
T
Tomásik
E
E
Mardiak
J
J
Danisovicovà
A
A
Trupl
T
T
Krcméry
V
V
D000328:Adult; D001424:Bacterial Infections / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D016527:Drug Costs; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000191:economics / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D012074:Remission Induction; D015996:Survival Rate; D013997:Time Factors
D015725:Fluconazole; D015242:Ofloxacin