title: Ability of hydroxyapatite-bone morphogenetic (corrected from morphologenetic) protein (BMP) complex to induce dentin formation in dogs.
abstract: This histological investigation examined the formation and differentiation of pulp cells under the influence of HAP/BMP complex. HAP/BMP complex was implanted in exposed pulp of the mandibular premolars and alveolar bone defect in the dog. Sequential changes in these areas were examined mainly under a light microscope and partly under a scanning electron microscope. Two weeks after the operation, fibroblast-like cells proliferated right beneath the implanted complex, and after 3 weeks, dentin including dentin tubules grew in the pulp. After four weeks a dentin bridge composed of osteoid dentin was found, and after 8 weeks this dentin calcified and covered the defective surface of the root and adhered to new bone surrounding the HAP granules. The results indicated that the dentin induced by HAP/BMP complex may be of two types: tubular dentin and osteodentin. This complex exhibited outstanding ability to induce dentinogenesis and osteogenesis.
authors.affiliation: Department of Anatomy, Osaka Dental University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Suwa
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: Y R
authors.initials: YR
authors.lastname: Fang
authors.forename: H
authors.initials: H
authors.lastname: Ike
authors.forename: T
authors.initials: T
authors.lastname: Deguchi
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins; D002454:Cell Differentiation; D002455:Cell Division; D003782:Dental Pulp / Q000166:cytology; D003804:Dentin / Q000166:cytology; D003810:Dentinogenesis / Q000502:physiology*; D004285:Dogs; D017886:Durapatite; D008297:Male; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000502:physiology*; D011506:Proteins / Q000502:physiology*
chemical_list: D019485:Bone Morphogenetic Proteins; D011506:Proteins; D017886:Durapatite