title: The subtyping of schizophrenia in men and women: a latent class analysis.
abstract: Latent class analysis on an epidemiologically based series of 447 first contact patients with a broad diagnosis of schizophrenia revealed evidence for two subtypes: a 'neurodevelopmental' type characterized by early onset, poor pre-morbid social adjustment, restricted affect and a male:female ratio of 7:3; and a 'paranoid' type characterized by later onset, persecutory delusions and an almost equal sex ratio. A third 'schizoaffective' subtype, whose existence was less clear cut, was almost entirely confined to females and characterized by dysphoria and persecutory delusions, and had negligible familial risk of schizophrenia. The aetiological, biological and clinical significance of this typology remains to be tested.
authors.affiliation: Genetics Section, Institute of Psychiatry, London.
authors.forename: D J
authors.initials: DJ
authors.lastname: Castle
authors.forename: P C
authors.initials: PC
authors.lastname: Sham
authors.forename: S
authors.initials: S
authors.lastname: Wessely
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000145:classification / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D012737:Sex Factors