Virus infections in mice with targeted gene disruptions.
The experimental dissection of the ways that the various cells and molecules of the immune system interact to promote virus clearance has been greatly facilitated by the availability of mice with targeted disruptions of key genes. New insights are emerging, and details of host resistance mechanisms that could only be inferred for the in vivo situation are now being clearly established.
Doherty
P C
PC
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D017353:Gene Deletion; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology*
D016207:Cytokines; D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I