title: Intraoperative use of rtPA for subarachnoid hemorrhage.
abstract: Intraoperative thrombolysis with recombinant tissue plasminogen activator (rtPA) was performed in 15 patients with aneurysmal subarachnoid hemorrhage. All patients had significant basal cistern blood accumulation seen on CT scans preoperatively. The patients underwent surgery within four days of subarachnoid hemorrhage with aneurysm clipping in all patients. Postoperatively, transcranial doppler examinations demonstrated reduction in the development of vasospasm to a greater degree in patients treated with rtPA than a similar group of patients managed without the rtPA treatment. Eighty percent of patients receiving intracisternal rtPA had fair to good results compared with 78% of a similar group of patients who underwent surgery shortly after subarachnoid hemorrhage and were not given rtPA. Intracisternal rtPA remains an adjunctive treatment of questionable benefit in the management of patients with aneurysmal subarachnoid hemorrhage.
authors.affiliation: Department of Neurosciences, Charleston Area Medical Center, W. Va.
authors.forename: J H
authors.initials: JH
authors.lastname: Schmidt
authors.forename: J T
authors.initials: JT
authors.lastname: Christenson
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator