Coexistence of glucocorticoid receptor and pharmacokinetic abnormalities: factors that contribute to a poor response to treatment with glucocorticoids in children with asthma.
Rapid glucocorticoid clearance and abnormal glucocorticoid receptor binding have been described as factors that contribute to an inadequate response to treatment with glucocorticoids in patients with asthma. We report the coexistence of these abnormalities in children with severe asthma who respond poorly to systemic glucocorticoid therapy.
Kamada
A K
AK
Ira. J. and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Spahn
J D
JD
Surs
W
W
Brown
E
E
Leung
D Y
DY
Szefler
S J
SJ
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008775:Methylprednisolone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011239:Prednisolone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011965:Receptors, Glucocorticoid
D011965:Receptors, Glucocorticoid; D011239:Prednisolone; D008775:Methylprednisolone