Initial observation on albendazole in combination with cimetidine for the treatment of human cystic echinococcosis.
Concentrations of albendazole were measured, by high-pressure liquid chromatography, in 19 patients being treated for cystic echinococcosis. All of the patients were given three 4-week courses of albendazole (20 mg/kg/day), separated by 10-day-long drug-free intervals. Seven patients also received three courses of cimetidine (10 mg/kg/day). Concentrations of albendazole sulphoxide (ABZSX) were significantly higher in samples of bile and hydatid cyst fluid from the patients receiving albendazole and cimetidine than in those from patients receiving albendazole alone (P < 0.05). The therapeutic benefit of the combined drug treatment, which was well-tolerated, was more than that with albendazole alone.
Wen
H
H
Department of Surgery and Pharmaceutics, Xinjiang Medical College, China.
Zhang
H W
HW
Muhmut
M
M
Zou
P F
PF
New
R R
RR
Craig
P S
PS
D015766:Albendazole / Q000031:analogs & derivatives / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000871:Anthelmintics / Q000378:metabolism; D001646:Bile / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002927:Cimetidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004443:Echinococcosis / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans
D000871:Anthelmintics; D002927:Cimetidine; D015766:Albendazole; C027186:albendazole sulfoxide