Analysis of herpesvirus genomes in Kikuchi's disease.
We examined the cervical lymph nodes of 30 patients with Kikuchi's disease and 15 patients with non-specific lymphadenitis, using Southern blot analysis and polymerase chain reaction (PCR) to identify human herpesviruses such as Epstein-Barr virus (EBV), cytomegalovirus, herpes simplex virus, and varicella-zoster virus. By Southern blot analysis, no virus DNA was recognized, but 16 of the 30 nodes from patients with Kikuchi's disease and 8 of the 15 nodes from patients with non-specific lymphadenitis showed amplified EBV DNA by PCR.
Sumiyoshi
Y
Y
First Department of Pathology, School of Medicine, Fukuoka University, Japan.
Kikuchi
M
M
Minematu
T
T
Ohshima
K
K
Takeshita
M
M
Minamishima
Y
Y
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D015139:Blotting, Southern; D002648:Child; D005260:Female; D016679:Genome, Viral; D006564:Herpesviridae / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology*; D008199:Lymphadenitis / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction