Chronic monitoring of cardiovascular function in the conscious guinea pig using radio-telemetry.
An implantable radio-telemetry device for chronic monitoring of arterial pressure and heart rate in the conscious guinea pig was validated against measurements using an exteriorized, indwelling catheter. There were no significant differences between simultaneous measurements in animals instrumented with both the telemetry system and the conventional catheter (implanted 24 hrs prior to comparisons) in response to a variety of vasoactive agents. The device was shown to be accurate up to 3 weeks after implantation (longest time point tested). Resting pressures and heart rates in the telemetered guinea pig were stable in 100% of the animals tested. In contrast, animals instrumented with only exteriorized catheters showed a significant decline in pressure by 8 days after surgery and a 39% attrition rate due to loss of catheter patency. Performance of the telemetric device was examined in both normal and sodium-deficient animals, since the latter is a useful normotensive model in which blood pressure is rendered highly renin-dependent for evaluating the efficacy of potential antihypertensive agents that target the renin-angiotensin system. The telemetered guinea pig is an appropriate model for assessing responses to chronic exposure of cardiovascular agents.
DePasquale
M J
MJ
Department of Cardiovascular/Metabolic Diseases, Pfizer Central Research, Groton, Connecticut 06340.
Ringer
L W
LW
Winslow
R L
RL
Buchholz
R A
RA
Fossa
A A
AA
D000818:Animals; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D006168:Guinea Pigs; D006339:Heart Rate; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D011674:Pulse; D012044:Regression Analysis; D013686:Telemetry; D013997:Time Factors