Neurological complications in children with protein C deficiency.
Four children with a cerebrovascular occlusive accident and protein C deficiency are described. Two patients presented with an acute hemiplegia, the others suffered from a transient ischemic attack and a progressive hydrocephalus as the result of sinus thrombosis. In all cases protein C deficiency, Type 1, was diagnosed. Other causes of cerebrovascular disease were excluded. Although venous thrombosis has been extensively reported in protein C deficiency, these cases indicate that protein C deficiency is also related to arterial thrombosis. In evaluating children with cerebrovascular accidents, protein C deficiency should also be considered.
van Kuijck
M A
MA
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Rotteveel
J J
JJ
van Oostrom
C G
CG
Novakova
I
I
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D008297:Male; D020151:Protein C Deficiency; D011488:Protein Deficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014057:Tomography, X-Ray Computed