title: Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two-year-old child.
abstract: A two-year-old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications.
authors.affiliation: Department of Pediatrics, University of Graz, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Muntean
authors.forename: W
authors.initials: W
authors.lastname: Zenz
authors.forename: K
authors.initials: K
authors.lastname: Finding
authors.forename: G
authors.initials: G
authors.lastname: Zobel
authors.forename: A
authors.initials: A
authors.lastname: Beitzke
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology*; D002417:Cattle; D002675:Child, Preschool; D005165:Factor V / Q000037:antagonists & inhibitors*; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011651:Pulmonary Artery / Q000601:surgery; D013348:Subclavian Artery / Q000601:surgery
chemical_list: D015718:Fibrin Tissue Adhesive; D005165:Factor V