title: Positivity of patch tests in cutaneous reaction to diclofenac. Two case reports.
abstract: Immune-mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48-72 h after administration of diclofenac sodium. Patch tests performed with diclofenac were positive. The histopathologic findings resembled those of contact dermatitis with different degrees of dermal involvement. Clinical, allergologic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessment of possible immunologic mechanisms underlying cutaneous reactions to drugs.
authors.affiliation: Istituto di Clinica Medica, Università Cattolica del S. Cuore, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: F
authors.initials: F
authors.lastname: Pietrantonio
authors.forename: M
authors.initials: M
authors.lastname: Di Fonso
authors.forename: A
authors.initials: A
authors.lastname: Garcovich
authors.forename: C
authors.initials: C
authors.lastname: Chiarelli
authors.forename: A
authors.initials: A
authors.lastname: Venuti
authors.forename: C
authors.initials: C
authors.lastname: Barone
mesh_terms: D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000276:immunology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology*; D008875:Middle Aged; D010267:Parapsoriasis / Q000139:chemically induced / Q000276:immunology*; D010328:Patch Tests
chemical_list: D004008:Diclofenac