title: Possible association between the hernia of Morgagni and trisomy 21.
abstract: Of the 5 liveborn infants with the hernia of Morgagni recorded in the California Birth Defects Monitoring Program, 3 had trisomy 21. This significant association (P < 10(-6)) between the hernia of Morgagni and trisomy 21 may reflect defective dorsoventral migration of rhabdomyoblasts from the paraxial myotomes, caused by increased cellular adhesiveness in trisomy 21.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
authors.forename: L H
authors.initials: LH
authors.lastname: Honoré
authors.forename: C P
authors.initials: CP
authors.lastname: Torfs
authors.forename: C J
authors.initials: CJ
authors.lastname: Curry
mesh_terms: D002465:Cell Movement; D002891:Chromosomes, Human, Pair 21; D003964:Diaphragm / Q000196:embryology; D004314:Down Syndrome / Q000150:complications*; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000235:genetics*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn