title: Butorphanol does not reduce the minimum alveolar concentration of halothane in dogs.
abstract: This study evaluated the effect of butorphanol tartrate, a synthetic opioid agonist-antagonist, on halothane minimum alveolar concentration (MAC) in dogs. Baseline halothane MAC was determined in each of six dogs. Butorphanol was administered and halothane MAC was redetermined. Each dog received butorphanol at 0.2, 0.4, and 0.8 mg/kg intravenously at 1 week intervals. Heart rate and arterial blood pressure decreased after butorphanol administration, but returned to baseline by 50 minutes. There was little effect on respiratory parameters. A halothane-sparing effect was not noted with any butorphanol dose.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602-7390.
authors.forename: J E
authors.initials: JE
authors.lastname: Quandt
authors.forename: M R
authors.initials: MR
authors.lastname: Raffe
authors.forename: E P
authors.initials: EP
authors.lastname: Robinson
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002077:Butorphanol / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004347:Drug Interactions; D005260:Female; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D012119:Respiration / Q000187:drug effects
chemical_list: D002077:Butorphanol; D006221:Halothane