title: A naturally occurring model of immunoglobulin E antibody-mediated hypersensitivity in laboratory animals.
abstract: A naturally occurring model of immunoglobulin E (IgE) antibody-mediated hypersensitivity in canine and rhesus monkey species to environmental allergens is described. Cutaneous responses to a dust mite mix (Dermatophagoides farinae/pteronyssinus) and to four storage mite extracts (Aleuroglyphus ovatus, Blomia tropicalis, Chortoglyphus sp., Lepidoglyphus destructor) occurred in the canine species. Rhesus monkeys had IgE antibody-mediated hypersensitivity to dust mite on cutaneous challenge, but to a lesser degree than the canine species. Biologic relevance was verified by eliciting positive airway challenges in both species. The IgE antibody-mediated basis of these responses was confirmed by passive transfer technique. Demonstration of dust mite allergy provides a naturally occurring model of IgE antibody-mediated hypersensitivity in the canine and rhesus monkey species. Storage mite IgE antibody-mediated hypersensitivity exists in the canine species.
authors.affiliation: Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
authors.forename: M B
authors.initials: MB
authors.lastname: Hogan
authors.forename: K E
authors.initials: KE
authors.lastname: Harris
authors.forename: R
authors.initials: R
authors.lastname: Patterson
mesh_terms: D000336:Aerosols; D000485:Allergens / Q000276:immunology; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004391:Dust; D005260:Female; D006967:Hypersensitivity / Q000276:immunology* / Q000503:physiopathology; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000276:immunology*; D008168:Lung / Q000503:physiopathology; D008253:Macaca mulatta; D008297:Male; D008925:Mites / Q000276:immunology; D012882:Skin Tests
chemical_list: D000336:Aerosols; D000485:Allergens; D004391:Dust; D007073:Immunoglobulin E