[The effect of glucocorticoid hormones on the blood coagulation and fibrinolytic activity of the gastroduodenal mucosa in bronchial asthma patients].
Gastrofibroscopic findings for 164 patients with bacterial asthma (BA) showed high frequency of gastroduodenal ulcer occurrence. Mucosal biopsy extracts from the stomach and duodenum of BA patients demonstrate high hemocoagulative and low anticoagulative activities. Enhanced fibrin-formation in inhibition of fibrinolytic activity in gastroduodenal mucosa vessels causes local circulatory disorders. This fact explains well frequent findings of the ulcer in BA patients. Antibiotic therapy does not affect enzymatic activity of gastroduodenal zone in BA patients and eventually does not aggravate ulcer lesions. Corticosteroid hormones stimulate hemocoagulative activity in the zone and further inhibit anticoagulative activity. This results in further ulceration and appearance of new lesions.
Tabidze
Z Sh
ZSh
D000328:Adult; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001706:Biopsy; D001777:Blood Coagulation / Q000187:drug effects*; D002102:Cadaver; D004359:Drug Therapy, Combination; D004386:Duodenum / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D005938:Glucocorticoids
Vliianie gliukokortikoidnykh gormonov na gemokoaguliruiushchuiu i fibrinoliticheskuiu aktivnost' gastroduodenal'noĭ slizistoĭ obolochki bol'nykh bronkhial'noĭ astmoĭ.