A primate model for chancroid.
Adult pigtailed macaques (Macaca nemestrina) were evaluated for their usefulness as a primate model for chancroid. To initiate infection, 10(7)-10(8) cfu of Haemophilus ducreyi were inoculated into the foreskins of 5 adult males and into the vaginal labia of 4 adult females. Lesions developed in the male macaques that were similar in appearance, histopathologic changes, and progression to those of human disease, including the development of ulcers 6-12 days after infection. In addition, H. ducreyi could be recovered from the lesions up to 20 days after inoculation, humoral antibodies were induced beginning 1 week after inoculation, and inguinal lymphadenopathy was noted in 4 of the 5 males. None of the 4 female macaques inoculated with the same preparation of live H. ducreyi developed comparable lesions. Thus, experimental chancroid in adult male macaques closely resembles human disease and should be useful for future studies of the pathogenesis of chancroid.
Totten
P A
PA
Department of Medicine, University of Washington, Seattle.
Morton
W R
WR
Knitter
G H
GH
Clark
A M
AM
Kiviat
N B
NB
Stamm
W E
WE
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002602:Chancroid / Q000276:immunology / Q000503:physiopathology / Q000635:transmission; D004195:Disease Models, Animal; D005260:Female; D005835:Genitalia / Q000382:microbiology / Q000473:pathology; D006191:Haemophilus ducreyi / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology; D008254:Macaca nemestrina; D008297:Male; D014774:Virulence
D000907:Antibodies, Bacterial