Coincident DiGeorge anomaly and renal agenesis and its relation to maternal diabetes.
We describe 2 cases of DiGeorge anomaly with bilateral renal agenesis-one, who also had hemivertebrae, in an infant of an insulin-dependent diabetic mother (IDDM). In a review we identified 2 other instances of this combination, both in IDDMs. The currently accepted notion that DiGeorge anomaly and renal agenesis are developmental field defects, coupled with their coincidence in IDDM, suggests that this combination is an association.
Novak
R W
RW
Children's Hospital Medical Center, Akron, OH 44308-1062.
Robinson
H B
HB
D000015:Abnormalities, Multiple / Q000209:etiology*; D000293:Adolescent; D004062:DiGeorge Syndrome / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D011247:Pregnancy; D011253:Pregnancy in Adolescence; D011254:Pregnancy in Diabetics; D013131:Spine / Q000002:abnormalities