A case report of drug-induced allergic hepatitis probably due to the N-methyltetrazolethiol group cephalosporin.
Drug-induced allergic hepatitis occurred in a patient being treated with cefpiramide sodium. A lymphocyte blast transformation test suggested that the N-methyltetrazolethiol group of the drug was responsible for the induction of acute hepatitis. A detailed case report and discussion of the relevant literature are presented in this paper.
Kojima
N
N
Third Department of Internal Medicine, Ehime University School of Medicine.
Kumamoto
I
I
Masumoto
T
T
Onji
M
M
D000208:Acute Disease; D000328:Adult; D002511:Cephalosporins / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects
D002511:Cephalosporins; C036666:cefpiramide