title: [Effects of 6-(alpha alpha-diphenylacetylpiperazinyl) phenyl-5-methyl-4,5-dihydro-3 (2H)-pyridazinone on rabbit platelet aggregation and TXB2, cAMP production].
abstract: 6-(alpha alpha-diphenylacetylpiperazinyl) phenyl-5-methyl-4,5-dihydro-3 (2H)-pyridazinone (DMDP) is a new synthetic pyridazinone derivative. This compound was shown to inhibit AA, ADP and PAF-induced rabbit platelet aggregation, and its IC50s were found to be 1.12 +/- 0.1, 4.19 +/- 0.5 and 2.97 +/- 0.1 mumol/L, respectively. At the concentration range of 1-500 mumol/L, the compound was found to depress TXB2 content and to increase cAMP levels in washed rabbit platelets in a dose-dependent manner. These might be the mechanisms of the compound on the inhibition of rabbit platelets.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Zeng
authors.forename: X S
authors.initials: XS
authors.lastname: Wang
authors.forename: D X
authors.initials: DX
authors.lastname: Sun
authors.forename: A Y
authors.initials: AY
authors.lastname: Lin
authors.forename: Y
authors.initials: Y
authors.lastname: Ji
authors.forename: J X
authors.initials: JX
authors.lastname: Chu
authors.forename: Y C
authors.initials: YC
authors.lastname: Rui
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D011817:Rabbits; D013929:Thromboxane B2 / Q000096:biosynthesis*
chemical_list: D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines; C083460:6-(diphenylacetylpiperazinyl)pheny-5-methyl-4,5-dihydro-3-(2H)-pyridazinone; D013929:Thromboxane B2; D000242:Cyclic AMP