title: An antileishmanial chalcone from Chinese licorice roots.
abstract: A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.
authors.affiliation: Department of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen.
authors.forename: S B
authors.initials: SB
authors.lastname: Christensen
authors.forename: C
authors.initials: C
authors.lastname: Ming
authors.forename: L
authors.initials: L
authors.lastname: Andersen
authors.forename: U
authors.initials: U
authors.lastname: Hjørne
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: C
authors.initials: C
authors.lastname: Cornett
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D002681:China; D006035:Glycyrrhiza / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal
chemical_list: C087613:1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propen-1-one; D000981:Antiprotozoal Agents; D047188:Chalcones; C087614:1-(3-(3-methyl-2-butenyl)-2,4-(dihydroxy)phenyl)-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-propen-1-one; D002599:Chalcone