[The characteristics of the effect of imperialone on the M-cholinoreceptors of different organs].
The pharmacological studies of the steroidal alkaloid imperialone have revealed its high M-cholinolytic activity on the heart, which was accompanied by sensibilization of M-cholinoreceptors in the secretory cells of lacrimal, salivary, and gastric glands and M-receptors in the smooth muscle of the intestine and urinary bladder. Bearing in mind the currently available data on M-cholinoreceptors, imperialone can be regarded as M2-cholinolytics having M3- and M4-cholinopotentiating properties. Imperialone is a potent agent used for selective cardiac M2-receptor blockade and for enhancement of the functional activity of smooth muscle and secretory organs that have M3- or M4-cholinoreceptors.
Mirzaev
Iu R
IuR
Plotnikova
I T
IT
Shakirov
R
R
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002595:Cevanes / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006321:Heart / Q000187:drug effects; D007765:Lacrimal Apparatus / Q000187:drug effects; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012469:Salivary Glands / Q000187:drug effects; D013270:Stomach / Q000187:drug effects
D002317:Cardiovascular Agents; D002595:Cevanes; D010276:Parasympatholytics; D011976:Receptors, Muscarinic; C084300:imperialone; D001285:Atropine
Ob osobennostiakh vliianiia imperialona na M-kholinoretseptory razlichnykh organov.