title: [Primary antiphospholipid syndrome and cerebrovascular disease].
abstract: Primary antiphospholipid syndrome (PAS) is characterized by the isolated presence of antiphospholipid antibodies in the absence of other immunological changes. Its association with ischemic cerebrovascular disease is rarely reported. This study analyzes this association in 10 patients (8 women) first presenting with ischemic cerebrovascular accident (ICVA) that met the criteria for PAS. The average age of the patients was 50.4 years. Two patients had Sneddon's syndrome. Prolonged thromboplastin partial activation time was found in only three patients. Eight started aspirin therapy. The average time of follow-up was 17.2 months, during which there was one relapse. PAS should be included as a possible cause when examining individuals with ICVA, particularly when patients are young, when abortion has occurred or when no other cause is evident. Acetylsalicylic acid is effective for preventing relapse when other vascular risk factors are carefully controlled.
authors.affiliation: Servicio de Neurología, Hospital Universitario Virgen del Rocío, Sevilla.
authors.forename: J M
authors.initials: JM
authors.lastname: López Domínguez
authors.forename: J L
authors.initials: JL
authors.lastname: Casado Chocán
authors.forename: J M
authors.initials: JM
authors.lastname: Aguilera Navarro
authors.forename: M
authors.initials: M
authors.lastname: Monedero Vega
authors.forename: J R
authors.initials: JR
authors.lastname: González Marcos
authors.forename: A
authors.initials: A
authors.lastname: Gil Peralta
mesh_terms: D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology*; D002544:Cerebral Infarction / Q000209:etiology* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D016682:Lupus Coagulation Inhibitor / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor
vernacular_title: Síndrome antifosfolípido primario y enfermedad cerebrovascular.