Analysis of heavy metals content in the brain with the use of electron paramagnetic resonance in a clinically unusual case of hepato-lenticular degeneration.
An analysis of heavy metals content in the brain of a clinically unusual case of hepatolenticular degeneration was performed with the use of paramagnetic resonance. The studies established a manyfold increase of copper content in the brain in the form of free ions, and, less significant, also in the form of copper multi-ion clusters. The content of iron in the studied brain was lower than in controls. These results confirmed significantly the neuropathological diagnosis of hepato-lenticular degeneration.
Wender
M
M
Department of Neurology School of Medicine, Poznań, Poland.
Szczech
J
J
Hoffmann
S
S
D000328:Adult; D001344:Autopsy; D001923:Brain Chemistry; D003300:Copper / Q000009:adverse effects* / Q000032:analysis*; D003937:Diagnosis, Differential; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D017809:Fatal Outcome; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007501:Iron / Q000009:adverse effects* / Q000032:analysis*; D008297:Male; D009497:Neurotic Disorders / Q000175:diagnosis / Q000523:psychology; D011699:Putamen / Q000473:pathology
D003300:Copper; D007501:Iron