title: [Hand and foot purpura ("glove and sock" syndrome) caused by parvovirus B19 infection].
abstract: After a period of general nonspecific symptoms (weakness; nocturnal sweating) for a few days a 29-year-old man suddenly developed a purpura-like rash on both hands and feet ("glove and sock") with mild itching and oedema. A blood count demonstrated leukopenia (2100/microliters) with neutropenia (1100/microliters), thrombocytopenia (81,000/microliters) and reticulocytopenia (1/1000), while haemoglobin content was normal. The bone-marrow showed almost complete reduction of erythropoiesis with the presence of giant proerythroblasts. Granulopoiesis and megakaryopoiesis were unremarkable. Positive tests for IgM and IgG antibodies against parvovirus B19 established the diagnosis of infection with this organism. The rash, blood picture and bone-marrow changes all regressed spontaneously, without any treatment, within a week. The petechial or purpuric "glove and sock" syndrome may be a special form of parvovirus B19 infection.
authors.affiliation: Innere Abteilung 2, Robert-Bosch-Krankenhaus Stuttgart.
authors.forename: E
authors.initials: E
authors.lastname: Hübel
authors.forename: E
authors.initials: E
authors.lastname: Ladda
authors.forename: B
authors.initials: B
authors.lastname: Löffler
authors.forename: K
authors.initials: K
authors.lastname: Schumacher
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D016731:Erythema Infectiosum / Q000097:blood / Q000175:diagnosis*; D005528:Foot; D006225:Hand; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D016732:Parvovirus B19, Human / Q000276:immunology*; D011693:Purpura / Q000097:blood / Q000175:diagnosis*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Manopedale Purpura ("glove and sock"-Syndrom) durch Parvovirus-B19-Infektion.