Tolerance of porcine renal allografts induced by donor spleen cells and seven days' treatment with cyclosporine.
Liver allografts in pigs and in rats elicit a substantial cellular immune response that can resolve spontaneously with the induction of donor-specific systemic tolerance. Self-limiting interactions between host and donor (graft)-derived leukocytes may be the basis for tolerogenesis. We have attempted to reproduce this effect of liver grafting in pigs by peroperative infusion of donor leukocytes into kidney graft recipients given an interrupted short course of CsA designed to promote donor leukocyte survival and interaction with host cells. This protocol can secure long-term kidney graft survival resistant to challenge by donor skin grafting. Donor skin is, however, rejected, but more slowly than third-party skin, indicating a degree of systemic specific unresponsiveness in these long-term kidney graft recipients.
Calne
R Y
RY
Department of Surgery, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Watson
C J
CJ
Brons
I G
IG
Makisalo
H
H
Metcalfe
S M
SM
Sriwatanawongsa
V
V
Davies
H S
HS
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D016038:Skin Transplantation / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013552:Swine
D016572:Cyclosporine