A model for analyzing the formation of thrombin in vessels.
A pseudo steady-state model is proposed to analyze the effects of a vessel-length, blood-flow velocities, and the concentration levels of Va/Xa/phospholipid complex on the formation of thrombin in an arterial vessel. The outlet concentrations of thrombin are calculated in either physiological or pathological coagulation process. Among those factors, blood-flow velocity is the most important factor which affects the amount of thrombin formation. The model and its results might be used as a reference for those who clinically manage coagulation problems of patients with severe sepsis.
Chung
T W
TW
Department of Chemical Engineering, University of Oklahoma, Norman 73019.
O'Rear
E A
EA
D001160:Arterioles / Q000033:anatomy & histology / Q000378:metabolism* / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D004058:Diffusion; D018056:Hemorheology; D006801:Humans; D008433:Mathematics; D008955:Models, Cardiovascular; D011516:Prothrombin / Q000032:analysis / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology; D013917:Thrombin / Q000032:analysis / Q000096:biosynthesis*
D011516:Prothrombin; D013917:Thrombin