title: Brain perfusion SPECT in children with frequent fits.
abstract: We studied 14 children with frequent fits using 99mTc-HM-PAO single photon emission computed tomography (SPECT). There were 11 patients with partial secondary generalized epilepsy (PSGE) and 3 with Lennox-Gastaut syndrome (LGS). The typical regional cerebral blood flow (rCBF) finding in PSGE was a single area of abnormally low perfused cortex, and that in LGS, multiple hypoperfused areas. Clinically, the LGS patients were more severely affected. SPECT was more sensitive in detecting abnormalities than EEG, CT or MRI. Extensive impairment of rCBF may thus indicate unfavourable development of intellectual performance and poor seizure control.
authors.affiliation: Department of Child Neurology, University Central Hospital, Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Heiskala
authors.forename: J
authors.initials: J
authors.lastname: Launes
authors.forename: H
authors.initials: H
authors.lastname: Pihko
authors.forename: P
authors.initials: P
authors.lastname: Nikkinen
authors.forename: P
authors.initials: P
authors.lastname: Santavuori
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000000981:diagnostic imaging*; D004829:Epilepsy, Generalized / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D013577:Syndrome; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime