title: On-line sample treatment for or via column liquid chromatography.
abstract: It is generally recognized that sample treatment often is the bottleneck in trace-level organic analysis. As far as column liquid chromatography (LC) is concerned, the design, and commercialization, of on-line and fully automated precolumn/analytical column LC systems with diode-array UV or mass spectrometric detection is a distinct step towards solving the existing problems. Small precolumns that can be packed with sorbents of divergent selectivity, and also on-line (electro)dialysis modules, have been shown to perform well in many environmental and biomedical applications. In addition, it is noteworthy that LC or rather, LC-type, trace enrichment and clean-up on such precolumns are increasingly being used as an on-line treatment step for aqueous samples prior to capillary gas chromatographic analysis.
authors.affiliation: Department of Analytical Chemistry, Free University, Amsterdam, Netherlands.
authors.forename: U A
authors.initials: UA
authors.lastname: Brinkman
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods; D008892:Milk / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical