Neuropathological changes induced by total cerebral ischemia (TCI) in a new experimental model.
We describe a new model of human ischemia encephalopathy in rabbits by means of cross-clamping the ascending aorta in combination with blood exsanguination from the right atrium. Rabbit hippocampal CAI pyramidal cells and cerebellar Purkinje cells showed only a few changes in the early period after ischemia, but 4 days after ischemia a significant decrease in cell count and marked degeneration of the remaining cells were observed. When the pathological findings 4 days after TCI in the hippocampal area and cerebellar area were compared, the rate of cytoclasis was found to be significantly higher in the latter than in the former.
Sagara
M
M
Department of Anesthesiology and Critical Care Medicine, Kagoshima University, Japan.
Haraguchi
M
M
Yoshimura
N
N
Yoshida
H
H
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology*; D011689:Purkinje Cells / Q000473:pathology; D017966:Pyramidal Cells / Q000473:pathology; D011817:Rabbits; D013997:Time Factors