title: Lipomedullipinoma: a source of hypermedullipinemia.
abstract: Previously we reported a case of persistent hypotension associated with hypermedullipinemia (Blood Pressure 1992; 1:138-148). The hypermedullipinemia appeared to result from the autonomous secretion of medullipin I (Med I) by renomedullary interstitial cells (RIC's) in the patient's remaining endstage kidney. The patient subsequently died. At autopsy, the remaining kidney contained a yellow mass (1 x 1 x 0.5 cm) consisting of adipocytes and RIC's, termed a lipomedullipinoma. This mass was extracted and chromatographed by procedures known to yield Med I. Med I was identified following these procedures. Renal tissue outside the yellow mass failed to yield Med I. It appears that the hypermedullipinemia of this case resulted from autonomous, hypersecretion of Med I by the lipomedullipinoma.
authors.affiliation: University of Tennessee, Department of Pathology, Memphis.
authors.forename: E E
authors.initials: EE
authors.lastname: Muirhead
authors.forename: D H
authors.initials: DH
authors.lastname: Streeten
authors.forename: L W
authors.initials: LW
authors.lastname: Byers
authors.forename: B
authors.initials: B
authors.lastname: Brooks
authors.forename: E T
authors.initials: ET
authors.lastname: Schroeder
mesh_terms: D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications; D007679:Kidney Medulla / Q000378:metabolism; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis / Q000097:blood*; D008067:Lipoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D051381:Rats; D013577:Syndrome
chemical_list: D008055:Lipids; C050534:medullipin I