[The mechanism of metabolic denitration of nitroheterocyclic compounds].
It has been found that denitration of nitroheterocyclic drugs (NHCC) in mouse liver homogenate is one of the pathways of their biotransformation. This process is accompanied by the release of NO and NO-heme iron complex formation. The yield of complex increases linearly with time of NHCC incubation with liver homogenate and depends on NHCC structure. The ESR spectrum of the complex represents a superposition of spectra of NO with hemoglobin and NO with the other heme-containing proteins. NHCC denitration is inhibited by metyrapone, which is an evidence of cytochrome P-450 involvement in their metabolic denitration.
Il'iasova
V B
VB
Buzukov
A A
AA
Tabak
M
M
Degterev
I A
IA
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006454:Hemoglobins / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D009574:Nitro Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D011335:Proadifen / Q000494:pharmacology
D006454:Hemoglobins; D006571:Heterocyclic Compounds; D009574:Nitro Compounds; D009569:Nitric Oxide; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; D008797:Metyrapone
K mekhanizmu metabolicheskogo denitrovaniia nitrogeterotsiklicheskikh soedineniĭ.