Cervical cancer: application of MR imaging in radiation therapy.
OBJECTIVE
To evaluate magnetic resonance (MR) imaging in the planning of radiation therapy for patients with cervical cancer.


METHODS
MR imaging was performed in 15 patients with predominantly advanced cervical carcinomas. Skin markings of the radiation ports were labeled with MR-detectable tubing and beads to assess the adequacy of port placement. Volume and extent of tumor at MR imaging were compared with those at physical and computed tomographic (CT) examinations.


RESULTS
Tumor involvement of normal structures (parametrium, vagina, endometrium) was more extensive at MR imaging than at clinical examination in six patients (40%) and at CT in five patients (33%), resulting in modification of the radiation fields in eight patients (53%). Tumor size was larger on MR images than at clinical examination in 11 patients (73%).


CONCLUSIONS
MR imaging can depict tumor volume and better delineate the extent of involvement than physical and CT examination. This can be useful for placement of radiation ports, especially when small boost fields are used.
Mayr
N A
NA
Division of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Tali
E T
ET
Yuh
W T
WT
Brown
B P
BP
Wen
B C
BC
Buller
R E
RE
Anderson
B
B
Hussey
D H
DH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000528:radiation effects; D001918:Brachytherapy; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008159:Lumbar Vertebrae / Q000528:radiation effects; D008279:Magnetic Resonance Imaging; D008536:Meglumine; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009942:Organometallic Compounds; D010347:Patient Care Planning; D010384:Pelvic Bones / Q000528:radiation effects; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012074:Remission Induction; D012447:Sacrum / Q000528:radiation effects; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy*
D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA