title: Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women.
abstract: Although women bear the brunt of gonococcal infection-related morbidity, few large studies of gonorrhea treatment in women have been conducted. In a multicenter, double-blind, placebo-controlled trial, 181 evaluable women with uncomplicated gonorrhea were treated with ciprofloxacin (250 mg orally; 94 women) or ceftriaxone (250 mg intramuscularly; 87 women). Twenty-four percent of the participants were infected with antibiotic-resistant Neisseria gonorrhoeae. Cervical gonorrhea was cured in 100% (93 of 93) of the women treated with ciprofloxacin and 99% (83 of 84) receiving ceftriaxone. All pharyngeal (n = 5) or rectal (n = 20) infections treated with ciprofloxacin were cured, as were ceftriaxone-treated patients with pharyngeal (n = 6) or rectal (n = 21) infection. Geometric mean MICs (range) for 248 pretreatment isolates were: penicillin, 0.28 (0.015 to 8.0); tetracycline, 0.46 (0.06 to 4); ciprofloxacin, 0.003 (0.002 to 0.015); and ceftriaxone, 0.004 (0.001 to 0.125) microgram/ml. Both drugs were well tolerated. Despite the high prevalence of antibiotic-resistant gonococci in these populations, 250 mg of oral ciprofloxacin was as effective as an injection of ceftriaxone.
authors.affiliation: University of Alabama, Birmingham 35294-0006.
authors.forename: E W
authors.initials: EW
authors.lastname: Hook
authors.forename: R B
authors.initials: RB
authors.lastname: Jones
authors.forename: D H
authors.initials: DH
authors.lastname: Martin
authors.forename: G A
authors.initials: GA
authors.lastname: Bolan
authors.forename: T F
authors.initials: TF
authors.lastname: Mroczkowski
authors.forename: T M
authors.initials: TM
authors.lastname: Neumann
authors.forename: J J
authors.initials: JJ
authors.lastname: Haag
authors.forename: R
authors.initials: R
authors.lastname: Echols
mesh_terms: D000293:Adolescent; D000328:Adult; D002443:Ceftriaxone / Q000009:adverse effects / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D011446:Prospective Studies
chemical_list: D002939:Ciprofloxacin; D002443:Ceftriaxone