Antioxidative properties of phenazone derivatives: differentiation between phenylbutazon and mofebutazon.
Both phenylbutazon and mofebutazon inhibit oxidative fragmentation of the methionine derivative, 2-keto-4-methylthio-butyric acid (KMB) by xanthine oxidase--or diaphorase mediated OH radical production. Differentiation of the two non-steroidal antiinflammatory drugs is possible by means of determining oxygen reduction by xanthine oxidase or diaphorase in the presence of the naphthoquinone, juglone, where only mofebutazon shows an inhibitory effect.
Schneider
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I
Institut für Botanik und Mikrobiologie, Biochemisches Labor, Technische Universität, München.
Elstner
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EF
D015086:2,6-Dichloroindophenol; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry; D008892:Milk / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D010653:Phenylbutazone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D011199:Potentiometry; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; C014632:2-keto-4-methylthiobutyric acid; D008715:Methionine; D015086:2,6-Dichloroindophenol; D014969:Xanthine Oxidase; D008058:Dihydrolipoamide Dehydrogenase; D010653:Phenylbutazone; C002374:mofebutazone