Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors.
The relation of habitual diet and cardiorespiratory fitness to plasma fibrinogen concentration, Factor VII activity (F VIIc), Factor X activity (F X), tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) concentrations, anti-thrombin III (AT III) and apolipoprotein(a) (Apo[a]) was analyzed in 111 normolipidemic men aged 51-53 years. Diet was evaluated by seven day food records. Maximal oxygen consumption and aerobic threshold were determined in maximal bicycle ergospirometry test based on breath-by-breath analysis of expired respiratory gas. Plasma fibrinogen was measured by thrombin method, F VIIc by one-stage coagulation method, AT III and F X colorimetrically, t-PA and PAI-1 antigens by ELISA and Apo(a) concentration radioimmunologically. Carbohydrate intake was negatively (r = -0.31, p < 0.001; r = -0.24, p < 0.01; r = -0.36, p < 0.001) and fat intake positively (r = 0.24, p < 0.01; r = 0.29, p < 0.001; r = 0.32, p < 0.001) related to F X, PAI-1, and t-PA, respectively. Aerobic threshold correlated negatively with fibrinogen (r = -0.33, p < 0.001) and F X (r = -0.30, p < 0.001). Fasting insulin was the strongest determinant for PAI-1 (r = 0.55, p < 0.001) and a significant positive correlate to F VIIc (r = 0.30, p < 0.001), F X (r = 0.28, p < 0.01) and t-PA (r = 0.47, p < 0.001). These data emphasize the importance that carbohydrate rich diet and cardiorespiratory fitness may have against thrombogenesis.
Rankinen
T
T
Kuopio Research Institute of Exercise Medicine, Finland.
Rauramaa
R
R
Väisänen
S
S
Penttilä
I M
IM
Uusitupa
M
M
D000332:Aerobiosis / Q000502:physiology; D000990:Antithrombin III / Q000378:metabolism; D001053:Apolipoproteins / Q000378:metabolism; D053241:Apoprotein(a); D001777:Blood Coagulation / Q000502:physiology*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D017270:Lipoprotein(a); D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000097:blood
D001053:Apolipoproteins; D004040:Dietary Carbohydrates; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; D000990:Antithrombin III; D005167:Factor VII; D005170:Factor X; D005340:Fibrinogen; D053241:Apoprotein(a); D010959:Tissue Plasminogen Activator