[Antibacterial sulfonamides, antiparasitic and antifungal derivatives of imidazole: evaluation of their antithyroid effects in the rat].
Antithyroid action of some antibacterial, antiparasitic or antifungal agents, was studied by 2 in vitro and 3 in vivo experimentations in the rat. These drugs can upset thyroid hormone synthesis by forming a molecular complex with iodine, and/or by inhibiting thyroid peroxidase activity. Rats treated with these drugs showed an hypothyroidism, demonstrated both by a decrease in T4 concentration and an hyperactivity of thyroid gland by positive feed-back, whose consequence was the presence of cylindrical cells. We noticed this iatrogenic hypothyroidism with all the drugs experimented, by an increase in thyroid gland weight. But the increase of rats body weight, which should have appeared, was not shown. The use of anabolic steroid is now forbidden, therefore, such drugs could be used for breeding animals, in order to gain body weight. Detection of use of these drugs in breeding, to obtain this side effect, should be advised.
Comby
F
F
Laboratoire de chimie organique et chimie thérapeutique, Faculté de pharmacie, Limoges, France.
Lagorce
J F
JF
Moulard
T
T
Buxeraud
J
J
Raby
C
C
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D007037:Hypothyroidism / Q000139:chemically induced; D007093:Imidazoles / Q000633:toxicity*; D007700:Kinetics; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009195:Peroxidase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D013449:Sulfonamides / Q000633:toxicity*; D013961:Thyroid Gland / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D013963:Thyroid Hormones / Q000096:biosynthesis
D000890:Anti-Infective Agents; D007093:Imidazoles; D013449:Sulfonamides; D013963:Thyroid Hormones; D009195:Peroxidase
Sulfamides antibactériens, antiparasitaires et antifongiques dérivés de l'imidazole: évaluation des effets antithyroïdiens sur le rat.