Inhibition of Toxoplasma gondii protein synthesis by azithromycin.
Azithromycin was shown to specifically inhibit the protein synthesis of Toxoplasma gondii in experimental systems by using free tachyzoites and T. gondii-infected mouse macrophages. RNA synthesis of the parasite was not affected by azithromycin. Inhibition of protein synthesis was also proportional to the relative anti-Toxoplasma activity of three macrolides.
Blais
J
J
Laboratoire et Service d'Infectiologie, Centre de Recherche du Centre Hospitalier, Université Laval, Québec, Canada.
Garneau
V
V
Chamberland
S
S
D000818:Animals; D000900:Anti-Bacterial Agents; D017963:Azithromycin / Q000494:pharmacology*; D002478:Cells, Cultured; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D018942:Macrolides; D008264:Macrophages / Q000382:microbiology; D008715:Methionine / Q000378:metabolism; D051379:Mice; D015800:Protozoan Proteins / Q000096:biosynthesis* / Q000187:drug effects; D016053:RNA, Protozoan / Q000096:biosynthesis / Q000187:drug effects; D013462:Sulfur Radioisotopes; D013997:Time Factors; D014122:Toxoplasma / Q000187:drug effects* / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D015800:Protozoan Proteins; D016053:RNA, Protozoan; D013462:Sulfur Radioisotopes; C053853:dirithromycin; D004917:Erythromycin; D017963:Azithromycin; D008715:Methionine