The subunit composition of a GABAA/benzodiazepine receptor from rat cerebellum.
The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have alpha 6, alpha 1, gamma 2S, gamma 2L, and beta 2 or beta 3 subunits colocalizing in the same receptor complex.
Khan
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Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City 64110-2499.
Gutierrez
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De Blas
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D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D002531:Cerebellum / Q000737:chemistry* / Q000166:cytology / Q000648:ultrastructure; D003975:Diazepam / Q000494:pharmacology; D008969:Molecular Sequence Data; D011233:Precipitin Tests; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis* / Q000737:chemistry / Q000276:immunology
D000906:Antibodies; D011963:Receptors, GABA-A; D003975:Diazepam