title: Isolation and characterization of adenovirus-associated VA RNAs of human adenovirus type 7.
abstract: Two genes for virus-associated VA RNAs in the human adenovirus type 7 (Ad7) genome are compared to Ad2, Ad4, Ad5, simian VA RNAs, and pol III transcripts of Epstein-Barr virus. The newly identified VA RNA-encoding genes of Ad7 contain two relatively conserved intragenic promoter (elements A and B), the double-stranded RNA-dependent protein kinase (PK) active site-binding domain and transcriptional terminators. The conserved features extend to the VA RNA genes of simian and avian origin.
authors.affiliation: Wyeth-Ayerst Research, Biotechnology and Microbiology Division, Philadelphia, PA 19101.
authors.forename: P P
authors.initials: PP
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Dheer
authors.forename: A
authors.initials: A
authors.lastname: Davis
authors.forename: P P
authors.initials: PP
authors.lastname: Hung
authors.forename: S G
authors.initials: SG
authors.lastname: Lee
mesh_terms: D000260:Adenoviruses, Human / Q000235:genetics*; D001483:Base Sequence; D016384:Consensus Sequence / Q000235:genetics; D017124:Conserved Sequence; D005814:Genes, Viral / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis* / Q000235:genetics; D015183:Restriction Mapping; D016415:Sequence Alignment
chemical_list: D012367:RNA, Viral; C052835:adenovirus associated RNA