Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD.
The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role in cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.
Hollander
E
E
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY.
Cohen
L J
LJ
DeCaria
C
C
Saoud
J B
JB
Stein
D J
DJ
Cooper
T B
TB
Islam
N N
NN
Liebowitz
M R
MR
Klein
D F
DF
D000328:Adult; D005260:Female; D005277:Fenfluramine / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000097:blood*; D010879:Piperazines / Q000097:blood* / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D017366:Serotonin Receptor Agonists / Q000097:blood* / Q000494:pharmacology; D013997:Time Factors
D010879:Piperazines; D017366:Serotonin Receptor Agonists; D005277:Fenfluramine; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone