Glycerol phosphorylcholine (GPC) and serine ethanolamine phosphodiester (SEP): evolutionary mirrored metabolites and their potential metabolic roles.
Water-soluble phosphodiesters (WSPDE) are a prominent feature of many 31P-NMR spectra; however, their role has remained somewhat of a mystery. What has been missed in almost all previous studies is the fact that two classes of WSPDE exist in vertebrates: those in mammals and those in the other (reptile-avian) line. The first is represented by glycerol phosphorylcholine and the second by serine ethanolamine phosphodiester. A further examination of the literature suggests a common role for all WSPDE as lysophospholipase inhibitors and therefore net sparers of phospholipids by decreasing phospholipid metabolic throughput.
Burt
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MRI Center, University of Illinois at Chicago 60612-7336.
Ribolow
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D000818:Animals; D005075:Biological Evolution; D005997:Glycerylphosphorylcholine / Q000378:metabolism*; D006801:Humans; D010740:Phospholipases / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010768:Phosphoserine / Q000031:analogs & derivatives* / Q000378:metabolism; D012995:Solubility; D013045:Species Specificity; D014867:Water; D014882:Water-Electrolyte Balance
D014867:Water; C013249:serine ethanolamine phosphate; D010768:Phosphoserine; D005997:Glycerylphosphorylcholine; D010740:Phospholipases; D010727:Phosphoric Diester Hydrolases