Tachykinin receptors in the rat isolated uterus.
Tachykinin receptors mediating uterotonic effects were examined in preparations from oestrogen-primed rats. In the absence of peptidase inhibitors [Lys5-MeLeu9-Nle10] NKA (4-10) was 14-fold more potent than neurokinin A (NKA), but the two peptides were equipotent in the presence of phosphoramidon alone and in combination with amastatin. The NK-2 receptor antagonist SR 48968 antagonised responses to the tachykinins. These findings indicate that an NK-2 receptor is present in the oestrogen-primed rat uterus and that endopeptidase 24.11 plays a major role to inactivate NKA in this tissue.
Fisher
L
L
Department of Pharmacology, Monash University, Clayton, Australia.
Pennefather
J N
JN
Hall
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology; D007700:Kinetics; D015288:Neurokinin A / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D064729:Neurokinin-1 Receptor Antagonists; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018040:Receptors, Neurokinin-1 / Q000502:physiology*; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors / Q000502:physiology*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D000900:Anti-Bacterial Agents; D001549:Benzamides; D006020:Glycopeptides; D064729:Neurokinin-1 Receptor Antagonists; D010446:Peptide Fragments; D010455:Peptides; D010880:Piperidines; D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; C083383:neurokinin A (4-10), Lys(5)-MeLeu(9)-Nle(10)-; D004958:Estradiol; C016977:amastatin; C073839:SR 48968; C007630:estradiol 17 beta-cypionate; D015288:Neurokinin A; D002217:Carbachol; C008890:phosphoramidon