title: Effect of endothelin, angiotensin II and ANP on proliferation of vascular smooth muscle cells and cardiomyocytes.
abstract: By means of cell culture, 3H-thymidine (3H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG II) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG II.
authors.affiliation: Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University, PRC.
authors.forename: J M
authors.initials: JM
authors.lastname: Wu
authors.forename: T
authors.initials: T
authors.lastname: Cheng
authors.forename: S D
authors.initials: SD
authors.lastname: Sun
authors.forename: D D
authors.initials: DD
authors.lastname: Niu
authors.forename: J X
authors.initials: JX
authors.lastname: Zhang
authors.forename: S H
authors.initials: SH
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.forename: C S
authors.initials: CS
authors.lastname: Tang
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D016232:Endothelins / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D009206:Myocardium / Q000166:cytology; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
chemical_list: D016232:Endothelins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D004247:DNA