title: An algorithm to generate low-resolution protein tertiary structures from knowledge of secondary structure.
abstract: An algorithm is described to assemble the three-dimensional fold of a protein starting from its secondary structure. A reduced representation of the polypeptide chain is used together with a crude potential based on pair hydrophobicities. The method is shown to be successful in locating the native topology for two 4-alpha-helix bundles, myohemerythrin and cytochrome b-562.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027.
authors.forename: A
authors.initials: A
authors.lastname: Monge
authors.forename: R A
authors.initials: RA
authors.lastname: Friesner
authors.forename: B
authors.initials: B
authors.lastname: Honig
mesh_terms: D000465:Algorithms; D003573:Cytochrome b Group / Q000737:chemistry; D029968:Escherichia coli Proteins; D006422:Hemerythrin / Q000031:analogs & derivatives / Q000737:chemistry; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D003573:Cytochrome b Group; D029968:Escherichia coli Proteins; D006422:Hemerythrin; C008571:myohemerythrin; C017850:cytochrome b562, E coli