Cigarette smoke aggravates acid-induced duodenal mucosal injury in the rat. Role of mesenteric vasoconstriction.
In anesthetized rats we tested the hypothesis that cigarette smoke potentiates acid-induced duodenal mucosal injury by inducing mesenteric vasoconstriction. Rats inhaled room air or 6 or 12 ml/min cigarette smoke. Study 1: 0.1 N HCl-induced duodenal mucosal injury and H+ loss were assessed by histologic evaluation and titration, respectively. Study 2: Superior mesenteric artery blood flow was assessed by pulsed Doppler flowmetry before and during inhalation of cigarette smoke or room air. Twelve milliliter per minute of cigarette smoke aggravated 0.1 N HCl-induced duodenal mucosal injury by significantly increasing the number of villi with deep villous damage. The increased damage was associated with significantly greater loss of H+ from the duodenal lumen. Cigarette smoke produced a dose-related reduction in mesenteric blood flow. We conclude that the vasoconstrictive effect of cigarette smoke on mesenteric blood flow may be involved in the potentiation of acid-induced duodenal mucosal injury.
Zhang
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Research and Medical Services, Sepulveda Veterans Administration Medical Center, UCLA School of Medicine.
Leung
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D000818:Animals; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D006851:Hydrochloric Acid; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D017538:Mesenteric Artery, Superior / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D012907:Smoking / Q000009:adverse effects*; D014661:Vasoconstriction / Q000502:physiology*
D006851:Hydrochloric Acid