Recurrent digoxin overdose and treatment with digoxin-specific Fab antibody fragments.
A case of overdose with digoxin on three separate occasions is presented. The patient received digoxin-specific Fab antibody fragments on each presentation without adverse effects. A discussion of digoxin toxicity and specific treatment follows. Immunologic aspects of therapy are emphasized.
Bosse
G M
GM
Department of Emergency Medicine, University of Louisville, Kentucky.
Pope
T M
TM
D000328:Adult; D004077:Digoxin / Q000276:immunology / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D008297:Male; D011041:Poisoning / Q000175:diagnosis / Q000628:therapy; D013406:Suicide, Attempted
D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin