title: [The comparative characteristics of the transmembrane ionic currents and the caffeine-induced responses of the smooth-muscle cells in the normal jejunum and under ionizing radiation exposure].
abstract: A comparative investigation of transmembrane ion currents and caffeine-induced responses of single smooth muscle cells isolated from the circular layer of rat small intestine was carried out by the method of "patch-clamp". No reliable difference in potential-dependent and amplitude-kinetic characteristics of transmembrane ion currents in cells of intact and irradiated with dose of 3 Gy rats was revealed. In cells of irradiated animals external application of caffeine (4 mM) was not accompanied by strong quick-inactivated transient Ca(2+)-dependent potassium current as in control. The results obtained suggest that single whole-body X-ray irradiation with dose of 3 Gy does not lead in 5 days to any reliable alteration of potential-controlled channels of rat small intestine smooth muscle cell plasma membranes causing at the same time the disturbance of Ca-binding function of intracellular pools.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Stepanov
authors.forename: D V
authors.initials: DV
authors.lastname: Gordienko
authors.forename: T D
authors.initials: TD
authors.lastname: Preobrazhenskaia
authors.forename: L I
authors.initials: LI
authors.lastname: Stepanova
authors.forename: V M
authors.initials: VM
authors.lastname: Voĭtsitskiĭ
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002469:Cell Separation; D007583:Jejunum / Q000166:cytology / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D051381:Rats; D014916:Whole-Body Irradiation
chemical_list: D002110:Caffeine
vernacular_title: Sravnitel'naia kharakteristika transmembrannykh ionnykh tokov i kofeinindutsirovannykh otvetov gladkomyshechnykh kletok toshcheĭ kishki v norme i pri vozdeĭstvii ioniziruiushcheĭ raidatsii.