Amlodipine-induced gingival overgrowth.
Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in their crevicular fluid. The significance of this finding in relation to the pathogenesis of this unwanted effect remains to be elucidated.
Seymour
R A
RA
Department of Restorative Dentistry, University of Newcastle-upon-Tyne, UK.
Ellis
J S
JS
Thomason
J M
JM
Monkman
S
S
Idle
J R
JR
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000009:adverse effects* / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D003094:Collagen; D003774:Dental Plaque Index; D004848:Epithelium / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000150:complications
D017311:Amlodipine; D003094:Collagen