title: Dual-isotope myocardial imaging: feasibility, advantages and limitations. Preliminary report on 231 consecutive patients.
abstract: Two hundred and thirty-one patients underwent dual-isotope myocardial imaging (rest thallium-201 followed by stress technetium-99m sestamibi). The feasibility of the procedure was excellent: camera scheduling flexibility was improved and the duration of the procedure was less than that of a classical stress-redistribution procedure. Interpretation of defects due to image attenuation was facilitated by the different attenuation properties of 201Tl and 99mTc-sestamibi in 11 of 19 patients. 201Tl cross-over on 99mTc was found to be 15% +/- 3% with doses of 201Tl and 99mTc-sestamibi of 3 and 10 mCi, respectively, and 7% +/- 2% with doses of 3 and 20 mCi. This protocol should preferentially be reserved for patients with a history of myocardial infarction and/or a basal left ventricular dysfunction, in whom assessment of myocardial viability is of major interest. Extensive clinical validation of the dual-isotope procedure is required and optimal acquisition and reconstruction parameters should be established.
authors.affiliation: Department of Nuclear Medicine, Avicenne University Hospital, Bobigny, France.
authors.forename: P
authors.initials: P
authors.lastname: Weinmann
authors.forename: J M
authors.initials: JM
authors.lastname: Foult
authors.forename: D
authors.initials: D
authors.lastname: Le Guludec
authors.forename: F
authors.initials: F
authors.lastname: Tamgac
authors.forename: D
authors.initials: D
authors.lastname: Rechtman
authors.forename: A
authors.initials: A
authors.lastname: Neuman
authors.forename: N
authors.initials: N
authors.lastname: Caillat-Vigneron
authors.forename: J L
authors.initials: JL
authors.lastname: Moretti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012146:Rest; D013312:Stress, Physiological; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi