Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors.
In summary, our studies show that IGFs are potent regulators of oligodendrocyte development and myelination in vitro and in vivo. IGFs act at several levels: by promoting proliferation of oligodendrocytes and oligodendrocyte precursors, by inducing immature oligodendrocyte precursors to develop into oligodendrocytes, and by regulating myelin gene expression and the amount of myelin produced per oligodendrocyte. Our findings indicate that IGFs play a crucial role in normal oligodendrocyte development and myelination, and suggest that IGFs may have applications for the promotion of remyelination in myelin disorders such as MS.
McMorris
F A
FA
Wistar Institute, Philadelphia, Pennsylvania 19104-4268.
Mozell
R L
RL
Carson
M J
MJ
Shinar
Y
Y
Meyer
R D
RD
Marchetti
N
N
D000818:Animals; D001921:Brain / Q000166:cytology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division; D002478:Cells, Cultured; D015870:Gene Expression; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000494:pharmacology*; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology*; D051379:Mice; D008822:Mice, Transgenic; D009185:Myelin Proteins / Q000096:biosynthesis; D009416:Nerve Regeneration / Q000187:drug effects; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats
D009185:Myelin Proteins; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II