Value of physiologic assessment of foregut symptoms in a surgical practice.
BACKGROUND
The aim of this study was to evaluate the reliability of symptoms in the diagnosis of gastroesophageal reflux disease and esophageal motility disorders as assessed by functional tests.


METHODS
In 365 patients referred for suspected esophageal functional disease, symptomatic assessment was compared with the results of esophageal manometry and ambulatory 24-hour pH monitoring of the distal esophagus.


RESULTS
Based on the patients' chief complaint, the symptomatic diagnosis was gastroesophageal reflux (44%), esophageal motor disorder (26%), chest pain of esophageal origin (9%), reflux and aspiration (8%), and abdominal pathology (12%). The symptomatic diagnosis was considerably altered by the results of the esophageal function tests: gastroesophageal reflux and motility disorders were found in all symptomatic diagnostic groups and a large number of patients in each group tested normal. The sensitivity and specificity of symptom-based diagnoses for functional disease were low.


CONCLUSIONS
The results of this study showed that symptoms are an unreliable guide of esophageal abnormality, illustrating the need for objective testing in these patients, particularly to avoid inappropriate medical or surgical therapy.
Costantini
M
M
Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612.
Crookes
P F
PF
Bremner
R M
RM
Hoeft
S F
SF
Ehsan
A
A
Peters
J H
JH
Bremner
C G
CG
DeMeester
T R
TR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D002637:Chest Pain / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis*; D004947:Esophagus / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis*; D013502:General Surgery; D006356:Heartburn / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011015:Pneumonia, Aspiration / Q000209:etiology; D011364:Professional Practice