Monoclonal antibodies directed against surface and intracellular antigens of mouse granulated metrial gland cells.
Rat monoclonal antibodies with reactivity directed against mouse GMG cells have been produced. One of the antibodies (GMG-1) reacts with a surface antigen of GMG cells and cross-reacts with T lymphocytes. Another (GMG-2) reacts with an intracellular antigen in GMG cells and with asialo-GM1 positive cells in the spleen. Three antibodies (GMG-3, -4, -5) bind to intracellular antigens in GMG cells. The cross-reactivity of these antibodies is discussed with reference to the lineage relationship of GMG cells to NK cells and T cells and the recent suggestion that NK cells and T cells have a common progenitor cell. It is proposed that GMG cells share this common progenitor cell but are otherwise independent of the NK or T cell lineages.
Stewart
I J
IJ
Faculty of Medicine, School of Biological Sciences, University of Southampton, UK.
Mukhtar
D D
DD
Sawyer
A M
AM
Wild
A E
AE
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000276:immunology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D003593:Cytoplasm / Q000276:immunology*; D005260:Female; D006825:Hybridomas; D007132:Immunoglobulin Isotypes; D007150:Immunohistochemistry; D008297:Male; D008791:Metrial Gland / Q000166:cytology* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007132:Immunoglobulin Isotypes