[Cyclosporin in ophthalmology].
Cyclosporine A is a selective T-cell immunosuppressant, and doesn't inhibit the phagocytic system to the same degree as do steroids. Significant nephrotoxicity has been associated with its systemic use for solid organ transplantation or chronic idiopathic uveitis. Topical administration of CsA 2% in olive oil reduces the risk of systemic side-effects and appears to be well tolerated without local toxicity. Ocular penetration currently limits its indications for corneo-scleral immune diseases or high-risk corneal grafts.
Rakic
J M
JM
C.H.U. Sart-Tilman, Ophtalmologie, Liège, Belgique.
D000287:Administration, Topical; D003316:Corneal Diseases / Q000188:drug therapy*; D016039:Corneal Transplantation; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects
D016572:Cyclosporine
La cyclosporine en ophtalmologie.