title: Evolution of Mg deficiency in rats.
abstract: We performed weekly analyses of the evolution of the bioavailability of the Mg cation over a period of 70 days in adult rats fed an Mg-deficient (0.02%) diet. The results generally showed an increase in digestive utilization (% absorption) and a decrease in Mg balance during the experimental period. The parameters most sensitive to Mg deficiency were increase in body weight and blood concentration of Mg (mg/100 ml), which had declined significantly after 7 days (p < 0.05). Significant declines in plasma (p < 0.02) and muscle Mg (p < 0.01) were not apparent until after 35 days. Magnesium content in bone decreased from day 49 onward (p < 0.05), whereas renal Mg concentration tended to rise slightly during the last 2 weeks of study. No change was found in brain Mg concentration.
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia, Universidad de Granada, España.
authors.forename: A
authors.initials: A
authors.lastname: Lerma
authors.forename: E
authors.initials: E
authors.lastname: Planells
authors.forename: P
authors.initials: P
authors.lastname: Aranda
authors.forename: J
authors.initials: J
authors.lastname: Llopis
mesh_terms: D000042:Absorption; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008274:Magnesium / Q000097:blood* / Q000378:metabolism; D008275:Magnesium Deficiency / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
chemical_list: D008274:Magnesium