title: Hb Footscray or alpha 133(H16) Ser-->Arg: a new hemoglobin variant.
abstract: Hb Footscray, alpha 133(H16) Ser-->Arg, is a newly described hemoglobin variant found in an adult male of Polish-Hungarian descent. Hematological data and stability by the isopropanol stability test were normal. The abnormal hemoglobin comprised 15% of total hemoglobin and migrated as a split band in the Hb F position on cellulose acetate at pH 8.6. Like Hb Manitoba, which is also a Ser-->Arg mutation and occurs in a very similar spatial position, the split bands presumably arise from the formation of asymmetric hybrids between Hb Footscray and Hb A.
authors.affiliation: Department of Clinical Biochemistry, Christchurch Hospital, New Zealand.
authors.forename: M C
authors.initials: MC
authors.lastname: Owen
authors.forename: J G
authors.initials: JG
authors.lastname: Hendy
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001797:Blood Protein Electrophoresis; D003062:Codon; D005914:Globins / Q000235:genetics*; D006441:Hemoglobin A / Q000737:chemistry; D006455:Hemoglobins, Abnormal / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010108:Oxyhemoglobins / Q000737:chemistry; D011487:Protein Conformation
chemical_list: D003062:Codon; D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; C085477:hemoglobin Val de Marne; D005914:Globins; D006441:Hemoglobin A; C042249:hemoglobin Manitoba