title: [Fluoxetin combined with cyclobenzaprine in the treatment of fibromyalgia].
abstract: The aim of this study is to evaluate the effectiveness of fluoxetin associated with cyclobenzaprine vs cyclobenzaprine in the treatment of fibromyalgia. Twenty-one females with fibromyalgia were randomly assigned to 2 groups: group A (11 patients) was treated over 12 weeks with fluoxetin (20 mg/die) and cyclobenzaprine (10 mg/die), group B with cyclobenzaprine (10 mg/die). Basally and after 12 weeks patient self-assessment of pain, number of painful tender points, tender points index and morning stiffness were evaluated. The study has shown a significant improvement of the examined parameters in both treatment groups; however the comparison between the two groups showed a greater effectiveness, statistically significant, of the treatment with Fluoxetin associated with cyclobenzaprine.
authors.affiliation: II U.O. di Medicina Generale, USL n.9, Prato, Presidio Ospedaliero.
authors.forename: F
authors.initials: F
authors.lastname: Cantini
authors.forename: F
authors.initials: F
authors.lastname: Bellandi
authors.forename: L
authors.initials: L
authors.lastname: Niccoli
authors.forename: O
authors.initials: O
authors.lastname: Di Munno
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy*; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D009125:Muscle Relaxants, Central; D005473:Fluoxetine; D000639:Amitriptyline; C004704:cyclobenzaprine
vernacular_title: Fluoxetina associata a ciclobenzaprina nel trattamento della fibromialgia.