Height, lung function, and mortality from cardiovascular disease among the elderly.
The relation between height and death from cardiovascular disease was studied in a cohort of 3,809 persons aged 65 years or older (85% of eligible individuals) enrolled in a population survey in 1982-1983 in East Boston, Massachusetts. Self-reported height and weight were obtained, and peak expiratory flow rate (PEFR) was measured using a mini-Wright peak flow meter (Armstrong Industries, North Brook, Illinois). Vital status and cause of death were obtained through 1988. The median height was 62 inches in women and 66 inches in men. After adjustment for age, body mass index, and cigarette smoking, the risk of cardiovascular death decreased with quintile of height in women, with relative risks of 1.65, 1.16, 1.15, 0.76, and 1.00 over successive quintiles, with the tallest as the referent (p trend = 0.015). The trend in men was not as strong, with relative risks of 1.22, 0.77, 0.90, 0.98, and 1.00 from the shortest to the tallest quintiles (not significant). In both men and women, the strongest association was found with height and height squared, indicating a curvilinear relation. Height remained a predictor in women after adjustment for PEFR and other risk factors. These data suggest that a relation between height and cardiovascular death that is not mediated by lung function exists in the elderly, at least among women.
Cook
N R
NR
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215.
Hebert
P R
PR
Satterfield
S
S
Taylor
J O
JO
Buring
J E
JE
Hennekens
C H
CH
D000367:Age Factors; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D016016:Proportional Hazards Models; D012307:Risk Factors; D012907:Smoking