title: [Neurological events in infective endocarditis].
abstract: OBJECTIVE
  The study of frequency, modalities and course of neurological complications of infective endocarditis (IE), as well as the current indication and value of supplementary examinations.
  
  
  METHODS
  Sixty-three patients with IE, 39 with native valve and 24 with valvar prosthesis, were prospectively studied; the mean age was 42 years and 45 (71.4%) were males. Two groups were formed: A) 41 patients without neurological events and B) 22 patients who presented 28 neurological events before or during hospitalization: ischemic cerebrovascular accident 20, hemorrhagic cerebrovascular accident 2, meningeal hemorrhage 2, meningitis 2, brain abscess 1 and seizure 1. All patients were submitted to neurological clinical examination; 57 computerized tomographies of the cranium, 28 arteriographies and 32 cerebrospinal fluid analysis were performed.
  
  
  RESULTS
  The incidence of neurological events corresponded to 34.92% of IE patients, with a clear predominance (85.71%) of vascular as compared to infectious manifestations. Mortality was 2.32 times higher in group B patients (22.73% x 9.76%), albeit p = 0.256, and was not related to staphylococcal etiology. The neurological events were not related to sex, age and presence of valvar prosthesis. The presence of neurological complications was greater (p = 0.047) in patients with simultaneous infections in two valves (mitral and aortic) and also (p = 0.00884) in those with IE in prosthesis implanted for less than three months. All supplementary neurological examinations in group A were normal.
  
  
  CONCLUSIONS
  1) Occurrence of neurological events is a factor which influences the prognosis of IE; 2) supplementary neurological examinations did not reveal subclinical neurological complications; 3) neurological complications were significantly more frequent in patients with simultaneous mitral and aortic valve IE; 4) IE in prosthesis implanted for less than 3 months has a greater probability to develop a neurological picture as compared to IE in prosthesis implanted for more than 3 months.
authors.affiliation: Instituto do Coração do Hospital das Clínicas, FMUSP.
authors.forename: W
authors.initials: W
authors.lastname: Lunardi
authors.forename: M
authors.initials: M
authors.lastname: Grinberg
authors.forename: M
authors.initials: M
authors.lastname: Scaff
authors.forename: I
authors.initials: I
authors.lastname: Antelmi
authors.forename: E
authors.initials: E
authors.lastname: Mutarelli
authors.forename: L J
authors.initials: LJ
authors.lastname: Kajita
authors.forename: A
authors.initials: A
authors.lastname: Esteves
authors.forename: F
authors.initials: F
authors.lastname: Tarasoutchi
authors.forename: L F
authors.initials: LF
authors.lastname: Cardoso
authors.forename: E
authors.initials: E
authors.lastname: Rossi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000209:etiology*; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000209:etiology*; D004697:Endocarditis, Bacterial / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
vernacular_title: Eventos neurológicos na endocardite infecciosa.