title: The role of capsaicin-sensitive sensory neurons in healing of HCl-induced gastric mucosal lesions in rats.
abstract: OBJECTIVE
  Capsaicin-sensitive sensory neurons are important in protecting the stomach against damage. This study investigated the role of these sensory neurons in the healing of gastric lesions.
  
  
  METHODS
  Rats fasted for 18 hours were given 1 mL of 0.6N HCl orally for induction of gastric lesions; they were then fed normally from 1 hour later. On various days after HCl treatment, the area of lesion, acid secretion, mucosal DNA synthesis, mucosal H+ permeability, and blood flow responses were measured.
  
  
  RESULTS
  Ablation of sensory neurons by capsaicin pretreatment did not affect the development of gastric lesions in response to HCl but significantly delayed the healing of these lesions. The damaged mucosa secreted less acid and had minimal changes in DNA synthesis but showed a marked increase in H+ permeability, resulting in luminal acid loss accompanied by an increase of mucosal blood flow. Sensory deafferentation did not have any influence on such changes in the damaged stomach, except the mucosal hyperemic response to acid.
  
  
  CONCLUSIONS
  Capsaicin-sensitive sensory neurons may contribute to the healing of gastric lesions by mediating the mucosal hyperemic responses associated with acid back-diffusion and by facilitating acid disposal in the mucosa.
authors.affiliation: Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Ueshima
authors.forename: T
authors.initials: T
authors.lastname: Ohuchi
authors.forename: S
authors.initials: S
authors.lastname: Okabe
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000473:pathology / Q000503:physiopathology*; D006851:Hydrochloric Acid; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology*
chemical_list: D006851:Hydrochloric Acid; D002211:Capsaicin