title: Free-radical activity after primary coronary angioplasty in acute myocardial infarction.
abstract: Free-radical activity in coronary venous outflow was assessed before and after reperfusion in nine patients with acute infarction who had undergone successful recanalization of the infarct-related artery by primary coronary angioplasty. Free-radical activity was measured in serum samples from coronary venous outflow over a timed period of 24 hours by using (1) the percentage molar ratio (PMR) of the diene conjugate 9,11-linoleic acid, and (2) malonaldehyde concentration. Preangioplasty PMR means lay within the normal range, but showed a marked increase soon after successful recanalization. Relative to baseline, the changes over time reached statistical significance between 2 and 60 minutes. No statistically significant changes in malonaldehyde occurred over the study period. We conclude that successful recanalization of the infarct artery is associated with significantly elevated free-radical activity, as measured by the PMR of conjugated diene, in coronary venous outflow. Such patients may be at risk from free radical mediated reperfusion injury.
authors.affiliation: Department of Cardiology, Cardiothoracic Centre, Liverpool, England.
authors.forename: E D
authors.initials: ED
authors.lastname: Grech
authors.forename: C M
authors.initials: CM
authors.lastname: Bellamy
authors.forename: M J
authors.initials: MJ
authors.lastname: Jackson
authors.forename: R A
authors.initials: RA
authors.lastname: Muirhead
authors.forename: E B
authors.initials: EB
authors.lastname: Faragher
authors.forename: D R
authors.initials: DR
authors.lastname: Ramsdale
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003331:Coronary Vessels; D005260:Female; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D016013:Likelihood Functions; D008041:Linoleic Acids / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000628:therapy*; D013997:Time Factors
chemical_list: D005609:Free Radicals; D008041:Linoleic Acids; D008054:Lipid Peroxides; D008315:Malondialdehyde