Prodepin: a new product of the adrenomedullin (ADM) gene has systemic vasodilator activity.
The purpose of the present study was to investigate the effects of products of the ADM gene other than ADM on systemic hemodynamics in the anesthetized rat, rabbit, piglet, cat and dog. Bolus intravenous (i.v.) injections of rat proADM22-41 (3-30 micrograms) significantly decreased systemic arterial pressure (SAP) and systemic vascular resistance in the anesthetized rat. Unlike ADM, rat proADM22-41 markedly increased cardiac output in the rat. Bolus i.v. injections of human proADM22-41 up to 500 micrograms had not effect in all species studied and rat proADM22-41 had no effect in species other than the rat. The present data suggest that rat proADM22-41 is a novel product of the ADM gene other than ADM and possesses marked systemic vasodilator activity. The present data also suggest that the hemodynamic activity of this peptide is species specific.
Lippton
H
H
Department of Internal Medicine, Louisiana State University Medical School, New Orleans 70112.
Gao
Y
Y
Lin
B
B
Heaton
J
J
Ferrara
J
J
DeVito
M
M
Granger
T
T
Pigott
J
J
Chang
J K
JK
Hyman
A
A
D053607:Adrenomedullin; D000818:Animals; D002415:Cats; D004285:Dogs; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000235:genetics / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013552:Swine; D014665:Vasodilator Agents / Q000494:pharmacology*
D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; D014665:Vasodilator Agents; D053607:Adrenomedullin; C087423:prodepin