Sequential alterations in tRNA population of 2-acetylaminofluorene-induced hepatocyte nodules.
In order to investigate the possible mechanisms by which cellular alterations can start an altered onco-developmental gene expression, we studied tRNA distribution profiles during the early steps of 2-acetylaminofluorene-induced hepatocarcinogenesis. The finding of progressive and sequential alterations appears to support the hypothesis of a causal connection between tRNA changes and nodular cell proliferation, possibly through the disruption of the mechanism which regulates tRNA functional adaptation.
Kanduc
D
D
Dept. Pathology, University of Toronto, Ontario, Canada.
Farber
E
E
Ghoshal
A
A
Nagai
M
M
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D008114:Liver Neoplasms, Experimental / Q000235:genetics*; D008297:Male; D011230:Precancerous Conditions / Q000235:genetics*; D012343:RNA, Transfer / Q000032:analysis*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D012343:RNA, Transfer; D015073:2-Acetylaminofluorene