A patient with Tn syndrome associated with myelodysplastic syndrome showed abnormal glycophorin B.
A Japanese male patient with myelodysplastic syndrome (MDS) was shown to have associated Tn syndrome; the first report of Tn syndrome with MDS. The Tn expression was demonstrated on erythrocytes, granulocytes, monocytes, platelets, and lymphocytes by flow cytometric analysis using a lectin and an antibody. Electrophoresis of erythrocyte membrane proteins revealed slower mobility of glycophorin B from the patient than that from normal individuals, suggesting a glycophorin B molecular abnormality.
Kamesaki
T
T
Department of Internal Medicine, Tottori Prefectural Central Hospital, Japan.
Akifuji
Y
Y
Mori
M
M
Ueki
J
J
Nakamoto
S
S
Kajii
E
E
Ikemoto
S
S
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism; D006021:Glycophorins / Q000378:metabolism*; D006402:Hematologic Diseases / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications*; D013577:Syndrome
D015295:Antigens, Tumor-Associated, Carbohydrate; D006021:Glycophorins; C040286:Tn antigen