title: Acquired purpura fulminans induced by alcohol and acetaminophen. Successful treatment with heparin and vitamin K.
abstract: Purpura fulminans is a rare syndrome of progressive hemorrhagic necrosis of the skin that may present as a dermatologic emergency. It most commonly affects children during the convalescent phase of a streptococcal infection or a viral exanthem. In adults, it may be associated with sepsis or acquired causes. Its pathogenesis has challenged physicians for decades. It has been discovered that purpura fulminans is almost always associated with disseminated intravascular coagulation and can occur in subjects with inherited or acquired deficiencies of the protein C anticoagulant pathway. Patients with liver compromise may also be potential candidates for coagulopathies secondary to hepatic dysfunction and impaired protein synthesis. It is widely recognized that individuals who consume alcohol on a long-term basis may develop severe hepatotoxicity from ingestion of therapeutic doses of acetaminophen (500 to 1000 mg every 4 to 6 hours). We have observed a patient with chronic alcoholism in whom hepatotoxicity and purpura fulminans developed secondary to the ingestion of acetaminophen.
authors.affiliation: Texas Tech University Health Sciences Center, Lubbock.
authors.forename: J L
authors.initials: JL
authors.lastname: Guccione
authors.forename: A
authors.initials: A
authors.lastname: Zemtsov
authors.forename: E
authors.initials: E
authors.lastname: Cobos
authors.forename: K H
authors.initials: KH
authors.lastname: Neldner
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000437:Alcoholism / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D011693:Purpura / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014812:Vitamin K / Q000008:administration & dosage*
chemical_list: D014812:Vitamin K; D000082:Acetaminophen; D006493:Heparin