Quantitative evaluation of 99mTc-GSA in the rat liver after ischemia-reperfusion injury.
99mTc-DTPA-galactosyl human serum albumin (Tc-GSA) is a new liver-imaging agent which binds specifically to hepatic binding protein. The purpose of this study was to evaluate the usefulness of Tc-GSA in quantitatively evaluating hepatic ischemia-reperfusion injury in the rat. Regional hepatic ischemia was induced by clamping the left hepatic artery and the left portal vein for 5 to 45 min. A hepatic accumulation index (t90) was obtained on the basis of the dynamic data. A significant difference of this index was observed between all ischemic groups and the control. In conclusion, 99mTc-GSA appears useful for evaluating the hepatic ischemia-reperfusion injury.
Hashimura
S
S
Department of Radiology, Okayama University Medical School, Japan.
Kohno
Y
Y
Gohbara
H
H
Niiya
H
H
Hiraki
Y
Y
D000818:Animals; D005069:Evaluation Studies as Topic; D007511:Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008102:Liver Circulation; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000000981:diagnostic imaging* / Q000473:pathology; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate