Alpha-mannosidosis. Report of a case with morphologic, cytologic and immunohistochemical considerations.
We report the histopathologic features of the knee bone and synovium and the cytologic features of the synovial fluid from a patient with alpha-mannosidosis. The synovium showed marked papillary hyperplasia with infiltration of foamy histiocytes containing periodic acid-Schiff-positive, diastase-resistant material. Severe degenerative changes were seen in the knee bone. The synovial fluid showed increased numbers of macrophages containing periodic acid-Schiff-positive, diastase-resistant material. The differential diagnostic considerations in the synovial fluid are also discussed.
Krishnan
B
B
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030.
Mody
D R
DR
Ramzy
I
I
D000328:Adult; D004912:Erythrocytes / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007719:Knee Joint / Q000473:pathology* / Q000601:surgery; D008264:Macrophages / Q000473:pathology; D008297:Male; D008361:Mannosidases / Q000172:deficiency*; D013582:Synovial Fluid / Q000166:cytology*; D013583:Synovial Membrane / Q000473:pathology* / Q000648:ultrastructure; D014617:Vacuoles / Q000473:pathology / Q000648:ultrastructure; D043323:alpha-Mannosidase; D008363:alpha-Mannosidosis / Q000473:pathology*
D008361:Mannosidases; D043323:alpha-Mannosidase