Antitumor activity of acemetacin in mice bearing colon 26 carcinoma: a preliminary report.
The antitumor activity of acemetacin (ACM) was examined in mice bearing colon 26 carcinoma and its effect was compared with indomethacin (IND). The addition of ACM (0.001-0.003%) to drinking water prolonged the survival time of mice bearing colon 26. On the other hand, prostaglandin E2 (PGE2) reduced the effect of ACM. The results suggest that the antitumor activity of ACM may be associated with the reduction of PGE2 levels.
Kisara
S
S
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Maekawa
I
I
Sasaki
K
K
Suzuki
N
N
Hayashi
A
A
Furusawa
S
S
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D015232:Dinoprostone / Q000494:pharmacology; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice
D000970:Antineoplastic Agents; C026784:acemetacin; D015232:Dinoprostone; D007213:Indomethacin