title: Diagnostic specificity of anti-neutrophil cytoplasmic antibodies (ANCA) in otorhinolaryngological diseases.
abstract: The incidence and titer of ANCA were examined with 871 sera from patients with otorhinolaryngological diseases at our hospital. The cytoplasmic pattern of ANCA (c-ANCA) whose titer was more than 16 was detected only in the sera of patients with Wegener's granulomatosis (WG). The incidence of c-ANCA in active WG was more than 90%. The perinuclear staining pattern of ANCA (p-ANCA) was detected in almost 40% of patients with Sjögren's syndrome, 2.0% of inflammatory diseases and 1.0% of tumorous diseases. A high diagnostic value of c-ANCA in WG was found in patients with otorhinolaryngological diseases.
authors.affiliation: Department of Otolaryngology, Yamagata University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fukase
authors.forename: N
authors.initials: N
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Inamura
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis*; D002467:Cell Nucleus / Q000276:immunology / Q000648:ultrastructure; D003593:Cytoplasm / Q000276:immunology / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D005734:Gangrene; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D009504:Neutrophils / Q000276:immunology / Q000648:ultrastructure; D009668:Nose Diseases / Q000175:diagnosis / Q000276:immunology; D010038:Otorhinolaryngologic Diseases / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis / Q000276:immunology; D012680:Sensitivity and Specificity; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers