title: Difficulties in the antenatal assessment of neonatal alloimmune thrombocytopenia.
abstract: In this paper we present a patient with an initially questionable history of neonatal alloimmune thrombocytopenia (NAT) due to materno-fetal HPA-1a (PLA1) incompatibility. No circulating antibodies were detectable in untreated maternal serum, but an adsorption/elution technique enabled the demonstration of the platelet-specific anti-HPA-1a (anti-PLA1) in maternal serum. Cordocentesis at 35 weeks of gestation revealed a fetal platelet count of 18 x 10(9)/l. Intrauterine platelet transfusion with HPA-1a (PLA1)-negative donor platelets was performed prior to cesarean section.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tübingen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Marzusch
authors.forename: J
authors.initials: J
authors.lastname: Fischer
authors.forename: J
authors.initials: J
authors.lastname: Dietl
authors.forename: E
authors.initials: E
authors.lastname: Wiest
authors.forename: K
authors.initials: K
authors.lastname: Völklein
authors.forename: M
authors.initials: M
authors.lastname: Schnaidt
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D016824:Antigens, Human Platelet; D007518:Isoantibodies