Change of polyamine level in various tissues of male rats intoxicated with paraquat.
The effects of paraquat (PQ) on the contents of putrescine (PUT), spermidine (SPD) and spermine (SPM) in the various tissues and organs were examined by means of high-performance liquid chromatography in rats intoxicated with the toxin by three intraperitoneal infusions of PQ for 6 days on every other day. The contents of PUT, SPD and SPM in the large intestine per mg of wet weight showed statistically significant decreases of 39 (P < 0.01), 73 (P < 0.01) and 27% (P < 0.05), respectively. In the liver, however, they showed statistically significant increases of 214 (P < 0.01), 39 (P < 0.05) and 78% (P < 0.01).
Watanabe
S
S
Department of Pharmacology, Kawasaki Medical School, Okayama, Japan.
Sato
S
S
Nagase
S
S
Tomita
M
M
Saito
T
T
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008297:Male; D010269:Paraquat / Q000493:pharmacokinetics / Q000633:toxicity*; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D014018:Tissue Distribution
D011073:Polyamines; D013096:Spermine; D010269:Paraquat; D013095:Spermidine; D011700:Putrescine