Calcium-dependent postsynaptic exocytosis: a possible mechanism for activity-dependent synaptic modulation.
Elevation of cytosolic Ca2+ level in the postsynaptic cell is critical for the induction of many forms of activity-dependent synaptic modulation. Based on our recent evidence that in muscle cells and fibroblasts constitutive exocytosis is increased by elevating cytosolic Ca2+ levels, we hypothesize that Ca(2+)-dependent exocytosis at the postsynaptic site may provide a mechanism for a localized, activity-dependent synaptic modulation.
Dan
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Department of Biological Sciences, Columbia University, New York, New York 10027.
Poo
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D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D005089:Exocytosis; D005347:Fibroblasts / Q000378:metabolism; D008954:Models, Biological; D009132:Muscles / Q000166:cytology / Q000378:metabolism; D009473:Neuronal Plasticity; D011892:Rana catesbeiana; D013569:Synapses / Q000502:physiology*
D000109:Acetylcholine; D002118:Calcium