Formation of 18-deoxy-19-noraldosterone by a human aldosterone-producing adenoma.
The recently synthesized 18-deoxy-19-noraldosterone is a potent aldosterone antagonist. In the present study we demonstrate the in vitro formation of 18-deoxy-19-noraldosterone from 19-noraldosterone in a human aldosterone-producing adenoma and normal adrenal tissue. The metabolite was isopolar, cochromatographed with the authentic standard on high-performance liquid chromatography, and the identity was further analyzed by mass spectrometry. The possible role of 18-deoxy-19-noraldosterone in primary aldosteronism is also discussed.
Takeda
Y
Y
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Iki
K
K
Miyamori
I
I
Takeda
R
R
D000236:Adenoma / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000450:Aldosterone / Q000096:biosynthesis*; D002851:Chromatography, High Pressure Liquid; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000378:metabolism*
D000451:Mineralocorticoid Receptor Antagonists; C027516:19-norcorticosterone; D000450:Aldosterone; D003345:Corticosterone