[Functional state of the reproductive system in patients with the hypogonadotropic form of amenorrhea during use of various protocols of ovulation induction with human menopausal gonadotropins].
Clinico-hormonal parameters of cycles stimulated with human menopausal gonadotropins in patients with hypogonadotropic amenorrhea and of spontaneous cycles in healthy women of reproductive age are compared. Estradiol hypersecretion in both phases of induced cycle was revealed: hydrocortisone in phase 1 and progesterone and testosterone in phase 2. Dexamethasone in daily dose 0.25 mg was administered for correction. This resulted in a noticeable reduction of estradiol hyperproduction in the first phase of stimulated cycles and in hyperandrogenism elimination. Folliculogenesis, ovulation, and early embryogenesis conditions in schemes of induction with human menopausal gonadotropins and dexamethasone therapy were close to physiologic ones, this resulting in increased share of fertile cycles.
Shchedrina
R N
RN
Nazarenko
T A
TA
Kolod'ko
V G
VG
Mullabaeva
S M
SM
Efremova
L D
LD
Kiriushkin
A V
AV
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000503:physiopathology*; D006062:Gonadotropins / Q000172:deficiency*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*
D006062:Gonadotropins; D008596:Menotropins
Osobennosti funktsional'nogo sostoianiie reproduktivnoĭ sistemy patsientok s gipogonadotropnoĭ formoĭ amenorei pri ispol'zovanii razlichnykh skhem induktsii ovuliatsii chelovecheskimi menopausal'nymi gonadotropinami.