title: Increased incidence of unpartnered single chromatids in metaphase II oocytes in 39,X(XO) mice.
abstract: Since rare cases of sex chromosome anomalies such as XXX and XXY were observed in the offspring of our XO breeder mice, we performed a cytogenetic analysis of metaphase II oocytes of XO mice to determine whether any changes in chromosomal configurations occur. We found a significantly increased incidence of unpartnered single chromatids in metaphase II oocytes of XO mice. Such single chromatids may contribute to embryonic aneuploidy. In addition, the tendency of the X-chromosome to segregate non-randomly to the oocyte rather than to the polar body was confirmed.
authors.affiliation: Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakurada
authors.forename: K
authors.initials: K
authors.lastname: Omoe
authors.forename: A
authors.initials: A
authors.lastname: Endo
mesh_terms: D000818:Animals; D002842:Chromatids / Q000528:radiation effects / Q000648:ultrastructure*; D003307:Copulation; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics*; D009865:Oocytes / Q000166:cytology* / Q000528:radiation effects; D012729:Sex Chromosome Aberrations; D014960:X Chromosome / Q000528:radiation effects / Q000648:ultrastructure*; D014965:X-Rays