Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.
Intrahepatic tumour is associated with alterations in splanchnic haemodynamics. To investigate the hypothesis that these are the result of a circulating vasoactive agent, rat small bowel segments were cross-perfused with arterial blood from groups (n = 12) of paired tumour-bearing (intrahepatic HSN sarcoma) and control rats. The vascular resistance of the segment was significantly greater during perfusion by tumour-bearing animals (91.6 mmHg ml-1 min, s.e. 21.5, vs 51.7 mmHg ml-1 min, s.e. 7.4, P < 0.05), suggesting that intrahepatic tumour may be associated with a circulating vasoactive agent. A similar mechanism may underlie changes in the hepatic perfusion index in patients with liver metastases.
Carter
R
R
University Department of Surgery, Glasgow Royal Infirmary, UK.
Anderson
J H
JH
Cooke
T G
TG
Baxter
J N
JN
Angerson
W J
WJ
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006439:Hemodynamics / Q000502:physiology*; D007421:Intestine, Small / Q000098:blood supply*; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012513:Sarcoma, Experimental / Q000503:physiopathology*; D013152:Splanchnic Circulation; D014655:Vascular Resistance