Type 2 cytokines and negative immune regulation in human infections.
Recent studies indicate that the human immune response to infection is regulated by the balance between the T helper type 1 cytokines, interleukin-2 and interferon-gamma, and the T helper type 2 cytokines, interleukin-4, interleukin-5 and interleukin-10. Interleukin-4 and interleukin-10 can facilitate antibody production but can also suppress cell-mediated immune responses. The net effect of these negative immunoregulatory cytokines is to favor progression of infection.
Modlin
R L
RL
Division of Dermatology, UCLA School of Medicine 90024-1750.
Nutman
T B
TB
D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D007378:Interleukins / Q000276:immunology; D009164:Mycobacterium Infections / Q000276:immunology*; D010272:Parasitic Diseases / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D007378:Interleukins