title: A multicenter comparative study of brodimoprim and amoxicillin therapy in the treatment of tonsillopharyngitis in adults.
abstract: OBJECTIVE
  To compare the efficacy and safety of brodimoprim (BDP) with those of amoxicillin (AMX) in patients with acute bacterial pharyngitis/tonsillitis.
  
  
  METHODS
  Randomized controlled study.
  
  
  METHODS
  Hospital and general practices in Austria, Germany and Switzerland.
  
  
  METHODS
  519 adult patients of both sexes aged 12 to 75 years.
  
  
  METHODS
  Patients were allocated to an 8- to 12-day treatment with BDP (400 mg loading dose followed by 200mg once a day) or AMX (750mg t.i.d).
  
  
  METHODS
  Resolution of clinical signs/symptoms and negative bacterial examination at completion of therapy.
  
  
  RESULTS
  Clinical cure/improvement rate of 97.8% and 94.8% in respectively the BDP and the AMX group. Bacterial eradication in 87.7% of the cases treated with BDP and 88.3% of those receiving AMX. Very good/good tolerability in 85.2% BDP- and 82.8% AMX treated patients.
authors.affiliation: ENT University, Köln.
authors.forename: R
authors.initials: R
authors.lastname: Nyffenegger
authors.forename: D
authors.initials: D
authors.lastname: Riebenfeld
authors.forename: K H
authors.initials: KH
authors.lastname: Bandau
authors.forename: M E
authors.initials: ME
authors.lastname: Nouri
authors.forename: U
authors.initials: U
authors.lastname: Schirmböck
authors.forename: M
authors.initials: M
authors.lastname: Streppel
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010612:Pharyngitis / Q000188:drug therapy*; D011008:Pneumococcal Infections; D013203:Staphylococcal Infections; D014069:Tonsillitis / Q000188:drug therapy*; D014295:Trimethoprim / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000658:Amoxicillin; D014295:Trimethoprim; C037079:brodimoprim