title: Effects of monoamine precursors on food intake in male rats.
abstract: Effects of monoamine precursors on food intake in male rats were studied. Rats were subjected to an artificial circadian pattern of eating, i.e., a five-hour feeding program during daytime and food deprived during the rest of day. Feeding responses after treatment of drugs were examined. Intraperitoneal injection of L-beta-3, 4-dihydroxyphenylalanine (L-DOPA), DL-threo-dihydroxyphenylserine (DOPS), or 5-hydroxy-L-tryptophan (5-HTP) suppressed food intake. The suppression occurred within the first thirty minutes of the test period and their order of potency came out 5-HTP > L-DOPA = DOPS. The suppressive action of 5-HTP was very strong and lasted at least 3 days. The mechanism of this feeding suppressed action by either the central satiety center or the peripheral inhibiting system was discussed in this context.
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, R.O.C.
authors.forename: W P
authors.initials: WP
authors.lastname: Pi
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
mesh_terms: D006916:5-Hydroxytryptophan / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D015103:Droxidopa / Q000008:administration & dosage / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007980:Levodopa; D006916:5-Hydroxytryptophan; D015103:Droxidopa