title: Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography.
abstract: A high performance liquid chromatographic method has been developed for the determination of rafoxanide and closantel in ovine plasma. Acetonitrile and chloroform were used for the extraction. The mean recoveries were 78.69% and 80.59% for rafoxanide and closantel, respectively. This method was applied to the characterization of rafoxanide plasma kinetics following oral administration of therapeutic doses to sheep.
authors.affiliation: Department of Veterinary Pharmacology, University of Glasgow Veterinary School, UK.
authors.forename: H A
authors.initials: HA
authors.lastname: Benchaoui
authors.forename: Q A
authors.initials: QA
authors.lastname: McKellar
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D011888:Rafoxanide / Q000097:blood* / Q000493:pharmacokinetics; D012458:Salicylanilides / Q000097:blood*; D012756:Sheep
chemical_list: D000871:Anthelmintics; D007202:Indicators and Reagents; D012458:Salicylanilides; D011888:Rafoxanide; C023342:closantel