A possible yeast homolog of human active-gene-repairing helicase ERCC6+.
We report here the sequencing and identification on the chromosome X of S. cerevisiae of an open reading frame, designated GTA1085, encoding a protein 1085 amino acids in size that displays significant homology to a of helicase subfamily. The highest similarity score is with ERCC6, a human putative helicase involved in the repair of active genes, with 53.3% identity over a stretch of 589 amino acids. This putative protein contains all seven consecutive domains conserved among DNA and RNA helicases. Thus, it apparently constitutes a novel member of this subfamily and might be involved, like ERCC6, in the preferential repair of active genes in yeast.
Huang
M E
ME
Laboratoire de Biochimie et Biologie Moléculaire, Unité de Recombinaisons Génétiques (UPR 41-CNRS), Faculté de Médecine, Rennes, France.
Chuat
J C
JC
Galibert
F
F
D000595:Amino Acid Sequence; D004265:DNA Helicases / Q000235:genetics*; D004260:DNA Repair; D004271:DNA, Fungal / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D004271:DNA, Fungal; D005656:Fungal Proteins; D004265:DNA Helicases