Non-endemic Burkitt's lymphoma in a patient with Bloom's syndrome.
Bloom's syndrome is an autosomal recessive disorder characterized by intrauterine growth retardation, typical physical signs, immunodeficiency and an increased risk of developing neoplasms at a young age, compared to the general population. Factors possibly involved in the pathogenesis of non-endemic Burkitt's lymphoma in a five year old girl with Bloom's syndrome are discussed. These include immunodeficiency, upregulated c-myc expression and an Epstein-Barr viral infection.
Vandenberghe
E
E
Centre for Human Genetics, K. U. Leuven, Belgium.
Van Hove
J
J
Brock
P
P
Schmidt
P
P
Delabie
J
J
Casteels-Van Daele
M
M
Cassiman
J J
JJ
Vanderschueren-Lodeweyckx
M
M
Van den Berghe
H
H
D001816:Bloom Syndrome / Q000150:complications* / Q000235:genetics / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000150:complications* / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D002675:Child, Preschool; D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D016259:Genes, myc; D013006:Growth Hormone / Q000009:adverse effects / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000150:complications / Q000382:microbiology
D004273:DNA, Neoplasm; D004279:DNA, Viral; D011994:Recombinant Proteins; D013006:Growth Hormone