[Platelet function after allogeneic bone marrow transplantation in Wiskott-Aldrich syndrome].
OBJECTIVE
To assess the platelet characteristics and functionalism in the Wiskott-Aldrich syndrome (WAS) after allogeneic BMT using cyclophosphamide and busulphan for conditioning.


METHODS
Two WAS patients underwent allogeneic BMT. Platelet aggregation was studied prior to and after BMT, along with the intraplatelet amount of ADP and ATP.


RESULTS
Platelet count, size and aggregation wholly recovered after BMT. The post-transplant content of platelet nucleotides was normal.


CONCLUSIONS
Platelet function can be totally restored with cyclophosphamide/busulphan conditioned BMT in WAS. Platelet defects in this disease are due to defective thrombopoiesis.
Megido
M
M
Servicio de Hematología, Hospital Ramón y Cajal, Madrid.
Cesar
J M
JM
Maldonado
M S
MS
Otheo
E
E
Muñoz
A
A
Navarro
J L
JL
D001792:Blood Platelets / Q000502:physiology*; D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation; D002066:Busulfan; D048429:Cell Size; D002675:Child, Preschool; D003520:Cyclophosphamide; D006085:Graft Survival; D006801:Humans; D010974:Platelet Aggregation; D010976:Platelet Count; D011184:Postoperative Period; D014923:Wiskott-Aldrich Syndrome / Q000097:blood* / Q000601:surgery
D003520:Cyclophosphamide; D002066:Busulfan
Estudio de la función plaquetaria después del trasplante alogénico de medula ósea en el síndrome de Wiskott-Aldrich.