[An evaluation of the skin-resorptive action of dimephosphon when used locally long term].
Experiments in rabbits and rats established that 15% dimephosphonum solution after its topical (skin) application over a long period of time (2 and 6 months) exerted no toxic skin-resorption effects, reduced blood lipid and lipid peroxidation product levels. The substance of dimephosphonum after 6-month daily skin applications caused reversible changes in renal and adrenal functions.
Ziganshina
L E
LE
Studentsova
I A
IA
Ziganshin
A U
AU
D000279:Administration, Cutaneous; D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000863:Antacids / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001769:Blood / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects*; D012996:Solutions; D013997:Time Factors
D000863:Antacids; D009943:Organophosphorus Compounds; D012996:Solutions; C049638:dimephosphon
Otsenka kozhno-rezorbtivnogo deĭstviia dimefosfona pri dlitel'nom mestnom primenenii.