title: Influence of the autonomic nervous system on circadian patterns of myocardial ischaemia: comparison of stable angina with the early postinfarction period.
abstract: OBJECTIVE
  To compare the circadian rhythm of myocardial ischaemia in patients with stable angina with that in patients in the early postinfarction period with particular emphasis on the role of the autonomic nervous system.
  
  
  METHODS
  44 patients with stable angina and ischaemia on treadmill testing (group A) were compared with 131 patients in the early postinfarction period (group B). All had 48 hour ambulatory Holter monitoring.
  
  
  METHODS
  Coronary care unit and cardiology department of a district general hospital.
  
  
  METHODS
  Prospective, between group, comparative study.
  
  
  RESULTS
  337 ischaemic episodes occurred in 35 patients in group A and 370 ischaemic episodes occurred in 65 patients in group B. 34% of patients in group A had only silent episodes of ischaemia compared with 97% in group B (p < 0.0001). In group A ischaemic episodes showed a circadian rhythm that peaked during the daytime hours (p < 0.0001), but this was not seen in group B. Both the high (0.15-0.40 Hz) and low (0.04-0.15 Hz) frequency spectral components of heart rate variability showed a clear circadian rhythm (p < 0.0001); peak values occurred during the sleeping hours, although this pattern was less pronounced in group B. The ratio of low to high frequency variability (a measure of sympathovagal balance) showed a peak in daytime hours in group A (p < 0.002), but this was not seen in group B.
  
  
  CONCLUSIONS
  In stable angina, myocardial ischaemia peaks during the day and is associated with a similar circadian rhythm of sympathovagal balance. In the early postinfarction period both the ischaemic and sympathovagal rhythms are severely diminished or lost altogether. Circadian changes in sympathovagal tone may explain, at least in part, the circadian rhythm of ambulatory myocardial ischaemia in patients with stable angina.
authors.affiliation: Department of Cardiology, London Chest Hospital.
authors.forename: B
authors.initials: B
authors.lastname: Marchant
authors.forename: R
authors.initials: R
authors.lastname: Stevenson
authors.forename: S
authors.initials: S
authors.lastname: Vaishnav
authors.forename: P
authors.initials: P
authors.lastname: Wilkinson
authors.forename: K
authors.initials: K
authors.lastname: Ranjadayalan
authors.forename: A D
authors.initials: AD
authors.lastname: Timmis
mesh_terms: D000787:Angina Pectoris / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002940:Circadian Rhythm; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology; D011446:Prospective Studies