High dosages of gonadotropins are associated with poor pregnancy outcomes after in vitro fertilization-embryo transfer.
OBJECTIVE
To compare the pregnancy outcomes during IVF-ET when different dosages of hMG are used after follicular phase suppression with leuprolide acetate (LA).


METHODS
Retrospective chart review.


METHODS
Hospital-based IVF-ET program.


METHODS
From January 1990 to December 1992, 264 cycles reached ET after LA downregulation and gonadotropin stimulation.


RESULTS
Higher doses of gonadotropins, as measured by both average daily dose and total dose per cycle, were associated with lower clinical pregnancy rates. This effect was independent of age, basal FSH level, endometrial thickness, maximal E2 levels, number of eggs retrieved, and embryos transferred.


CONCLUSIONS
High dosages of exogenous gonadotropins are associated with lower pregnancy rates in IVF-ET.
Stadtmauer
L
L
Department of Obstetrics and Gynecology, Columbia-Presbyterian Medical Center, New York, New York 10032.
Ditkoff
E C
EC
Session
D
D
Kelly
A
A
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000188:drug therapy; D008596:Menotropins / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D012189:Retrospective Studies
D006062:Gonadotropins; D004958:Estradiol; D008596:Menotropins; D005640:Follicle Stimulating Hormone