Comparative trial of acceptability of beclomethasone dipropionate and a new formulation of flunisolide.
A randomized, double-blind, crossover study of a new formulation of flunisolide nasal spray was performed comparing its acceptability and safety to that of aqueous beclomethasone dipropionate nasal spray. The single center study enrolled 100 adults with allergic rhinitis; of these, 99 provided valid data for analysis. Each study participant received a single dose of each study drug and assessed nasal burning/stinging and other adverse effects. Analysis of patient evaluations revealed no significant differences in nasal or pharyngeal irritation (P > .05); however, mild aftertaste was present with use of flunisolide (P = .059) compared with beclomethasone dipropionate. There was similar acceptance of both study drugs.
Conley
S F
SF
Department of Otolaryngology and Human Communication, Milwaukee, WI 53226.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage* / Q000592:standards; D004311:Double-Blind Method; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000592:standards; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D005446:Fluocinolone Acetonide; C007734:flunisolide; D001507:Beclomethasone