[The antiarrhythmic activity of the polymeric forms of quinidine, trimecaine, etatsizin, propranolol and verapamil].
The antiarrhythmic activity and acute toxicity of polymeric formulations of quinidine, trimecaine, ethacizine, propranolol, verapamil which had been immobilized on a cellulose carrier (monocarboxylcellulose) and low molecular analogues were studied in various experimental animals (rats, mice, dogs). The polymeric formulations of trimecaine and verapamil were found to have a higher antiarrhythmic activity in different arrhythmia models than trimecaine and verapamil. The toxicity of all new compounds was no more than the values of conventional antiarrhythmic drugs.
Sidorenko
G I
GI
Gurin
A V
AV
Koliadko
M G
MG
Iurkshtovich
T L
TL
Nedorezov
V L
VL
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000401:mortality; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D010640:Phenothiazines / Q000627:therapeutic use* / Q000633:toxicity; D011108:Polymers; D011433:Propranolol / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D011802:Quinidine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D014288:Trimecaine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D014700:Verapamil / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D011108:Polymers; D011433:Propranolol; D014700:Verapamil; C046818:ethacizine; D014288:Trimecaine; D011802:Quinidine
Antiaritmicheskaia aktivnost' polimernykh form khinidina, trimekaina, étatsizina, propranolola i verapamila.