Evaluation of the mutagenicity of 1-hydrazino-4-(3,5-dimethyl-1-pyrazolyl) pyridazino[4,5-b]indole.
The mutagenic potential of 1-hydrazino-4-(3,5-dimethyl-1-pyrazolyl) pyridazino [4,5-b]indole(A80a, CAS 135561-93-2), a new antihypertensive agent, was investigated in 3 test systems, according to the current EC Guidelines: Ames test with strains TA1535, TA1537, TA98 and TA100, SCE (sister chromatid exchange) test in V79 cells and micronucleus test in Swiss mice. No indications for a mutagenic potential were detected in bacteria and mice; positive results were obtained in eukaryotic cells. The potential for inducing chromosome aberrations in eukaryotic cells will be studied.
Lopez-de Cerain
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A
Centro de Investigación en Farmacobiología Aplicada (C.I.F.A.), Universidad de Navarra, Pamplona, Spain.
García
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E
Gullón
A
A
Alvarez
T
T
Losa
M J
MJ
Monge
A
A
D000818:Animals; D000959:Antihypertensive Agents / Q000633:toxicity*; D002460:Cell Line; D066298:In Vitro Techniques; D007211:Indoles / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011724:Pyridazines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects
D000959:Antihypertensive Agents; D007211:Indoles; D009153:Mutagens; D011724:Pyridazines; C071273:1-hydrazino-4-(3,5-dimethyl)-1-pyrazolyl-5H-pyridazino(4,5-b)indole