title: Absent end diastolic flow of umbilical artery Doppler: pregnancy outcome in 62 cases.
abstract: We retrospectively studied the outcome of pregnancy in 62 cases of absent end diastolic flow (AEDF) of umbilical artery Doppler flow velocity waveform. The history of pregnancies revealed that nearly all were of high risk. Many cases presented cerebral (65%) or uterine (55.5%) Doppler flow abnormalities, or both (38%). We noted 10 fetal deaths and decided 7 pregnancy terminations. Malformation and chromosomal defect rate was 16%. We noted 44 (71%) live-births, a very high rate of cesarean section (86%), prematurity (75%), small for gestational age (39%). Forty-five percent of the neonates had a 1-min Apgar score under 7, which dropped to 27% at 5 min. Neonate mortality rate was 6.9% and the total mortality rate was 34% (21/62). Morbidity was significant (7 cases with severe morbidity, 2 cases with chromosomal abnormality of poor prognosis). We compared different sub-groups with a view to looking for some prenatal factors which predict poor neonatal outcome in case of AEDF.
authors.affiliation: Department of Obstetrics, CHRU, Rennes, France.
authors.forename: P
authors.initials: P
authors.lastname: Poulain
authors.forename: J C
authors.initials: JC
authors.lastname: Palaric
authors.forename: J
authors.initials: J
authors.lastname: Milon
authors.forename: P
authors.initials: P
authors.lastname: Betremieux
authors.forename: J F
authors.initials: JF
authors.lastname: Proudhon
authors.forename: D
authors.initials: D
authors.lastname: Signorelli
authors.forename: J Y
authors.initials: JY
authors.lastname: Grall
authors.forename: J R
authors.initials: JR
authors.lastname: Giraud
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D000013:Congenital Abnormalities; D005260:Female; D005313:Fetal Death; D005316:Fetal Distress / Q000175:diagnosis* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D014469:Umbilical Arteries / Q000503:physiopathology*