title: Techniques used to evaluate the cutaneous microcirculation: application of photoplethysmography to the assessment of a phlebotropic agent in the treatment of leg ulcers.
abstract: Over recent years, a number of functional investigations have been developed that allow a better evaluation of the physiology of the cutaneous microcirculation than that provided by the morphologic method. These investigations are also useful in pharmacologic studies. Following a review of the anatomy and physiology of the cutaneous microcirculation, the author presents the principal techniques of investigation and the results obtained with Daflon 500 mg* on the cutaneous microcirculation evaluated by photoplethysmography of the skin in patients with venous insufficiency and leg ulcers.
authors.affiliation: Service de Dermatologie, Hôpital Caremeau, Nimes, France.
authors.forename: B
authors.initials: B
authors.lastname: Guillot
mesh_terms: D001794:Blood Pressure; D004145:Diosmin / Q000627:therapeutic use*; D004338:Drug Combinations; D005419:Flavonoids / Q000627:therapeutic use; D006569:Hesperidin / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D008833:Microcirculation / Q000187:drug effects; D017156:Photoplethysmography; D012867:Skin / Q000098:blood supply; D014647:Varicose Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D014689:Venous Insufficiency / Q000188:drug therapy
chemical_list: D004338:Drug Combinations; D005419:Flavonoids; C080675:S 5682; D004145:Diosmin; D006569:Hesperidin