title: Non-endemic Burkitt's lymphoma in a patient with Bloom's syndrome.
abstract: Bloom's syndrome is an autosomal recessive disorder characterized by intrauterine growth retardation, typical physical signs, immunodeficiency and an increased risk of developing neoplasms at a young age, compared to the general population. Factors possibly involved in the pathogenesis of non-endemic Burkitt's lymphoma in a five year old girl with Bloom's syndrome are discussed. These include immunodeficiency, upregulated c-myc expression and an Epstein-Barr viral infection.
authors.affiliation: Centre for Human Genetics, K. U. Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Vandenberghe
authors.forename: J
authors.initials: J
authors.lastname: Van Hove
authors.forename: P
authors.initials: P
authors.lastname: Brock
authors.forename: P
authors.initials: P
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Delabie
authors.forename: M
authors.initials: M
authors.lastname: Casteels-Van Daele
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: M
authors.initials: M
authors.lastname: Vanderschueren-Lodeweyckx
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D001816:Bloom Syndrome / Q000150:complications* / Q000235:genetics / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000150:complications* / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D002675:Child, Preschool; D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D016259:Genes, myc; D013006:Growth Hormone / Q000009:adverse effects / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000150:complications / Q000382:microbiology
chemical_list: D004273:DNA, Neoplasm; D004279:DNA, Viral; D011994:Recombinant Proteins; D013006:Growth Hormone