Tricyclic heteroaromatic systems pyrazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.
The synthesis and the benzodiazepine receptor activity of some pyrazolo[1,5-a]quinoxalines bearing various substituents on the tricyclic heteroaromatic system are reported. Only one of the tested compounds showed some receptor affinity.
Colotta
V
V
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
Cecchi
L
L
Catarzi
D
D
Conti
G
G
Filacchioni
G
G
Martini
C
C
Giusti
L
L
Lucacchini
A
A
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002707:Chlordiazepoxide / Q000494:pharmacology; D005445:Flunitrazepam / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
D011720:Pyrazoles; D011810:Quinoxalines; D011963:Receptors, GABA-A; D005445:Flunitrazepam; D002707:Chlordiazepoxide