Effect of genetically determined host factors on the efficacy of vidarabine, acyclovir and 5-trifluorothymidine in herpes simplex virus type 1 infection.
The susceptibility of Herpes simplex virus (HSV) to acyclovir (ACV), 5-trifluorothymidine (TFT) and vidarabine (Ara-A) in HSV-infected embryo fibroblasts from BALB/c and C57BL/6 mice as well as Vero cells were measured. Ara-A and TFT (at its highest concentration) were more effective in Vero cells and BALB/c mouse embryo fibroblasts (MEF) than in C57BL/6 MEF. In contrast, ACV was more effective in C57BL/6 MEF than BALB/c MEF and Vero cells. These data suggest that genetically determined differences in the ability of host cells to support the replication of HSV influence the activity of antiviral drugs.
Abghari
S Z
SZ
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga.
Stulting
R D
RD
Zhu
Z
Z
Schinazi
R F
RF
Kaufman
H E
HE
D000212:Acyclovir / Q000494:pharmacology*; D000818:Animals; D004622:Embryo, Mammalian / Q000382:microbiology; D005260:Female; D005347:Fibroblasts / Q000382:microbiology; D014644:Genetic Variation; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D014271:Trifluridine / Q000494:pharmacology*; D014709:Vero Cells; D014740:Vidarabine / Q000494:pharmacology*; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*
D014740:Vidarabine; D014271:Trifluridine; D000212:Acyclovir