Decrease in cerebral inositols in rats and humans.
Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.
Moats
R A
RA
Huntingdon Medical Research Institutes, Pasadena, CA 91105.
Lien
Y H
YH
Filippi
D
D
Ross
B D
BD
D000818:Animals; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006501:Hepatic Encephalopathy / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007294:Inositol