Granulocytic sarcoma showing chromosomal changes other than the t(8;21).
Cytogenetic analysis of a granulocytic sarcoma showed a 46,XX,der(X)t(X;1) (q28;q22), inv(3)(p21q27), inv(9)(p13q22),t(12;22)(p11;q11) karyotype. In addition, bone marrow aspirate disclosed the presence of cells with a 46,XX,inv(3)(p21q27),inv(9)(p13q22)(p11;q11) chromosomal pattern while the patient was clinically aleukemic. This case demonstrates that chromosomal abnormalities other than the classical t(8;21) can also be associated with granulocytic sarcoma.
Heimann
P
P
Department of Cytogenetics, Hôpital Universitaire Brugmann, Brussels, Belgium.
Vamos
E
E
Ferster
A
A
Sariban
E
E
D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008198:Lymph Nodes / Q000648:ultrastructure; D014178:Translocation, Genetic