title: Cardiac paraprotein associated with Waldenstrom's macroglobulinemia: a case report.
abstract: A case of myocardial paraprotein deposition in a patient with Waldenstrom's macroglobulinemia is presented. Routine light microscopy revealed diffuse widening of interstitial regions by pale eosinophilic material that had a grayish cast on trichrome stains and was Congo red negative. Immunofluorescence showed strong immunoglobulin M and kappa light chain staining around blood vessels but predominantly around myocytes. Ultrastructural examination revealed massive deposition of flocculent electron-dense material around myocytes and occasionally around blood vessels.
authors.affiliation: LDS Hospital Electron Microscopy Laboratory, Salt Lake City, Utah.
authors.forename: R L
authors.initials: RL
authors.lastname: Yowell
authors.forename: E H
authors.initials: EH
authors.lastname: Hammond
mesh_terms: D000328:Adult; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism*; D010266:Paraproteins / Q000378:metabolism*; D008258:Waldenstrom Macroglobulinemia / Q000378:metabolism*
chemical_list: D010266:Paraproteins