Who responds to prophylactic lithium therapy?
The search for predictors of outcome has not been particularly rewarding, and the use of lithium remains empirical: a trial of lithium is the most powerful predictor of outcome. However, lithium is a highly specific treatment for bipolar disorder. In non-bipolar affective disorder, factors of interest are correlates of bipolar disorder: mood-congruent psychotic features, retarded-endogenous profile, cyclothymic personality, positive family history of bipolar illness, periodicity, and normality between episodes of illness.
Abou-Saleh
M T
MT
Department of Psychiatry and Behavioural Science, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain.
D001714:Bipolar Disorder / Q000188:drug therapy / Q000517:prevention & control; D005260:Female; D006801:Humans; D008094:Lithium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D019964:Mood Disorders / Q000188:drug therapy / Q000517:prevention & control*; D011336:Probability; D016896:Treatment Outcome
D008094:Lithium