Balloon expandable intravascular stents: aortic implantation and late further dilation in growing minipigs.
Intravascular stents have been implanted in children with congenital and acquired vascular stenoses. Little information is known regarding the long-term results in growing patients, the implantation of multiple stents (in series), and the feasibility of further dilation. Nine stents were implanted in the abdominal aortas of 6 mini-pigs; in 3 pigs, 2 stents were implanted in series. Five pigs were recatheterized 196 +/- 17 days after stent implant. All stents were patent, with mild narrowing at the stent relative to the adjacent aorta; further stent dilation was performed. The stent diameter increased from 8.3 +/- 0.6 mm to 11.2 +/- 1.3 mm (p = 0.002), and the narrowing was relieved. These five pigs were catheterized 253 +/- 73 days after stent redilation. Each stent was patent without narrowing or pressure gradient. We conclude that intravascular stents do not interfere with normal growth, can be implanted in series, and can be further dilated.
Grifka
R G
RG
Lillie Frank Abercrombie Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Vick
G W
GW
O'Laughlin
M P
MP
Myers
T J
TJ
Morrow
W R
WR
Nihill
M R
MR
Kearney
D L
DL
Mullins
C E
CE
D000818:Animals; D001011:Aorta / Q000473:pathology; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods / Q000706:statistics & numerical data; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D015607:Stents / Q000706:statistics & numerical data; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors