Cochlear synaptic development and morphology in a genetically induced type of progressive hair cell degeneration.
In mice with genetically induced inner ear abnormalities it is conceivable that in the morphogenetic types and in mutants with the spotting kind of pigmentary anomaly, the genes act through the developing nervous system. It has been suggested that in degenerative (neuroepithelial) mutants the influence of the gene is also reflected in the inner ear through the agency of the nervous system. The jerker mouse belongs to the neuroepithelial type of mutants which in homozygotes results in early postnatal degeneration of the sensory epithelium of the inner ear, initially confined to the cuticular plate and the stereocilia. In spite of well-advanced hair cell degeneration, these mutants developed morphologically normal afferent and efferent nerve terminals at cochlear hair cells.
Sjöström
B
B
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital, Umeå, Sweden.
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003051:Cochlea / Q000254:growth & development / Q000294:innervation*; D003593:Cytoplasm / Q000648:ultrastructure; D003638:Deafness / Q000235:genetics / Q000473:pathology; D006198:Hair Cells, Auditory / Q000254:growth & development* / Q000473:pathology*; D006199:Hair Cells, Auditory, Inner / Q000254:growth & development / Q000473:pathology; D018072:Hair Cells, Auditory, Outer / Q000254:growth & development / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains; D008928:Mitochondria / Q000648:ultrastructure; D009410:Nerve Degeneration / Q000235:genetics*; D009411:Nerve Endings / Q000473:pathology; D009475:Neurons, Afferent / Q000473:pathology; D009476:Neurons, Efferent / Q000473:pathology; D017729:Presynaptic Terminals / Q000648:ultrastructure; D013569:Synapses / Q000473:pathology* / Q000502:physiology*; D013570:Synaptic Membranes / Q000473:pathology