[Subglottal stenosis as the initial manifestation in Wegener's disease].
A 21-year-old man with 3-month history of hoarseness and dyspnea was suspected to have Wegener's granulomatosis with initially appearing in the trachea. In spite of unspecific biopsies, the clinicopathological picture and the high titles of anticytoplasmic autoantibodies (ACPA) confirmed the diagnosis. The early treatment with cyclophosphamide impeded the evolution to graver systemic forms of the disease.
García-Ortega
F P
FP
Servicio de ORL, Hospital Universitario Arrixaca, Murcia.
Herrero
F
F
Pretel
L
L
Sánchez-Celemin
F
F
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005931:Glottis / Q000503:physiopathology; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007829:Laryngostenosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D007830:Larynx / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D014832:Voice Disorders / Q000209:etiology
D003520:Cyclophosphamide
Estenosis subglótica como primera manifestación de la enfermedad de Wegener.