Pharmacokinetic profile of brodimoprim: oral bioavailability and penetration into interstitial fluid.
The bioavailability of brodimoprim tablets given orally is 80-90%; their relative bioavailability compared to an aqueous solution is 100%. Penetration of brodimoprim to suction skin blisters is 73 +/- 8%. The elimination half-life is longer from blisters than from serum. The relative stability of extravascular concentrations suggests that, with adequate dose sizes, dosage may be once daily, and even only once every second day.
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Institute of Medical Microbiology, Kaptein W. Wilhelmsen og Frues Bakteriologiske Institutt, Rikshospitalet, Oslo, Norway.
D000284:Administration, Oral; D001682:Biological Availability; D002199:Capillary Permeability; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D014295:Trimethoprim / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D014295:Trimethoprim; C037079:brodimoprim