title: Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice.
abstract: Mice lethally infected with Candida albicans were exposed to small-particle aerosols containing amphotericin B-liposomes. The drug, when administered twice daily for 2 h (0.58 mg/kg of body weight per day) on days 1, 2, and 3 postinoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given 2 2-h treatments once a week for 4 weeks. A twice-weekly, 2-h small-particle aerosol administration of amphotericin B-liposomes for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.
authors.affiliation: Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: B E
authors.initials: BE
authors.lastname: Gilbert
authors.forename: P R
authors.initials: PR
authors.lastname: Wyde
authors.forename: G
authors.initials: G
authors.lastname: Lopez-Berestein
authors.forename: S Z
authors.initials: SZ
authors.lastname: Wilson
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols; D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004337:Drug Carriers; D005260:Female; D007668:Kidney / Q000382:microbiology; D008081:Liposomes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010316:Particle Size; D013154:Spleen / Q000382:microbiology
chemical_list: D000336:Aerosols; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B