[3H]-saxitoxinol metabolism and elimination in the rat.
Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9-microCi/kg; 3.8 micrograms/kg) were injected i.v. into each of six rats. Urine and fecal samples were collected up to 144 hr post-injection. Within 4 hr, 60% of injected radioactivity was excreted in urine. No radioactivity was found in feces. High performance liquid chromatography analyses of urine showed that saxitoxinol was not metabolized by the rats.
Hines
H B
HB
Pathophysiology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21701-5011.
Naseem
S M
SM
Wannemacher
R W
RW
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D008297:Male; D011041:Poisoning / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D012530:Saxitoxin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000506:poisoning / Q000652:urine; D014316:Tritium
D014316:Tritium; D012530:Saxitoxin; C083403:saxitoxinol