Study of myocardial infarct remodeling by single-photon emission computed tomographic imaging.
Left ventricular (LV) remodeling after Q-wave anterior acute myocardial infarction (AMI) was examined with single-photon emission computed tomographic thallium imaging. Initial (after adenosine infusion) and 4-hour delayed reinjection images were obtained in 34 patients aged 65 +/- 12 years. Short-axis slices from the delayed images were quantitatively analyzed by measuring the outer and inner diameters, and wall thickness. The results were compared with those in a group of normal subjects. The outer diameter was greater in patients than in normal subjects at the apical, mid- and basal levels (all p < 0.01); the average outer diameter was 16.9 +/- 1.9 mm in patients, and 12.2 +/- 1.3 mm in normal subjects (p < 0.001). Similarly, the inner diameter was greater in patients than in normal subjects at the 3 levels (all p < 0.05); the average inner diameter was 6.5 +/- 1.8 mm in patients, and 4.7 +/- 1.3 mm in normal subjects (p < 0.01). Wall thickness was greater in patients than in normal subjects (5.2 +/- 0.5 vs 3.8 +/- 0.5 mm; p < 0.0001). There were significant correlations between LV dilation and time elapsed (in weeks) since AMI (r = 0.57; p < 0.005), and the size of the perfusion abnormality (r = 0.44; p < 0.03). Thus, LV dilation occurs after Q-wave anterior AMI, and is related to infarct size and duration. These changes can be studied by single-photon emission computed tomographic thallium imaging.
Mallavarapu
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C
Philadelphia Heart Institute, Presbyterian Medical Center, Pennsylvania 19104.
Pancholy
S
S
Cave
V
V
Wasserleben
V
V
Heo
J
J
Iskandrian
A S
AS
D000241:Adenosine; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes; D000241:Adenosine