title: Oxygen and 99mTc-MAA shunt estimations in patients with pulmonary arteriovenous malformations: effects of changes in posture and lung volume.
abstract: BACKGROUND
  Patients with arteriovenous malformations are routinely monitored with arterial oxygen saturation (SaO2) estimations (breathing air) from which an oxygen shunt fraction can be calculated. This simple estimation has been compared with an anatomically defined estimate of the right to left shunt using a radioisotopic method. The fall in SaO2 which occurs in patients with pulmonary arteriovenous malformations in the erect posture and at high lung volumes was used to test the ability of SaO2 alone to follow changes in right to left shunt.
  
  
  METHODS
  Radiolabelled albumin macroaggregates (99mTc-MAA) or microspheres (MS) were injected intravenously and kidneys and lungs were imaged. The shunt fraction (QS/QTTc) in the supine position at functional residual capacity (baseline) was obtained by quantifying right kidney radioactivity. On standing or while breath holding at total lung capacity, shunt fraction was calculated from baseline QS/QTTc and from lung counts and the injected dose. Arterial oxygen saturation (SaO2) was recorded by a pulse oximeter for calculation of the oxygen shunt (QS/QTO2) (breathing air).
  
  
  RESULTS
  In the postural study (n = 8) SaO2 decreased from a mean (SD) value of 89 (5)% supine to 80 (6)% erect, corresponding to QS/QTO2 28 (8)% and 44 (8)% respectively. QS/QTTc increased from 28.7 (10.3)% to 39 (14.3)%. In the lung volume study (n = 8) QS/QTTc increased from 16.6 (11.5)% at functional residual capacity to 23.3 (11.9)% at total lung capacity while QS/QTO2 increased from 19.5 (7.5)% to 25.9 (10.6)% respectively. When all measurements were compared for QS/QTTc% and QS/QTO2% (n = 32) the difference in the mean values was 2.5% (absolute) and the limits of agreement between the two methods were +38% to -18% (relative). In neither the postural nor the volume study did delta (QS/QTO2) reliably predict delta (QS/QTTc)%.
  
  
  CONCLUSIONS
  In pulmonary arteriovenous malformations the simple physiological shunt calculated from SaO2 breathing air agreed well with the anatomical right to left shunt measured with 99mTc-MAA, but predicted poorly the changes in anatomical shunt induced by postural or lung volume changes.
authors.affiliation: Department of Medicine (Respiratory Division), Royal Postgraduate Medical School, Hammersmith Hospital, London.
authors.forename: J
authors.initials: J
authors.lastname: Ueki
authors.forename: J M
authors.initials: JM
authors.lastname: Hughes
authors.forename: A M
authors.initials: AM
authors.lastname: Peters
authors.forename: G J
authors.initials: GJ
authors.lastname: Bellingan
authors.forename: M A
authors.initials: MA
authors.lastname: Mohammed
authors.forename: J
authors.initials: J
authors.lastname: Dutton
authors.forename: W
authors.initials: W
authors.lastname: Ussov
authors.forename: D
authors.initials: D
authors.lastname: Knight
authors.forename: D
authors.initials: D
authors.lastname: Glass
mesh_terms: D000328:Adult; D001165:Arteriovenous Malformations / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011187:Posture / Q000502:physiology*; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; D010100:Oxygen