Exocrine pancreatic secretion in man following one week of M1-muscarinic receptor blockade.
A double-blind, randomized, placebo-controlled crossover study was performed to assess the influence of one week of selective M1-muscarinic receptor blockade on pancreatic exocrine secretion in man. Ten healthy subjects received telenzepine (3 mg p.o.) and placebo each for 8 days, with a 6-day drug-free washout interval between treatment sequences. On Day 8 of each sequence, pancreatic secretion was stimulated for 2 h by infusion of submaximal secretin (0.2 U.kg/h) followed by maximal stimulation with secretin (1.0 U.kg/h) and ceruletide (120 ng.kg/h). Telenzepine had no significant effect on secretory parameters during submaximal stimulation with secretin. During maximal stimulation, total protein, secretory volume, and output of amylase, trypsin and bicarbonate were unexpectedly increased by telenzepine. These findings might be partially explained by removal of the inhibitory influence of pancreatic polypeptide, which was depressed by telenzepine. Acute studies have shown that M1-receptor antagonists inhibit exocrine secretion. Our results suggest that adaptation of physiological mechanisms governing the exocrine pancreas may occur after one week of receptor blockade by a therapeutic dosage of telenzepine, to the extent that M1-blockade no longer inhibits secretion.
Malfertheiner
P
P
Internal Medicine I, University of Ulm, Germany.
Nelson
D K
DK
Kemmer
T P
TP
Glasbrenner
B
B
Schneider
A
A
Ditschuneit
H
H
D000328:Adult; D002108:Ceruletide; D004311:Double-Blind Method; D005260:Female; D005452:Fluoresceins; D006801:Humans; D007202:Indicators and Reagents; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010349:Patient Compliance; D010890:Pirenzepine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D012016:Reference Values; D012633:Secretin; D013997:Time Factors
D005452:Fluoresceins; D007202:Indicators and Reagents; D018727:Muscarinic Antagonists; C046338:telenzepine; D012633:Secretin; D010890:Pirenzepine; D002108:Ceruletide; C034833:fluorescein dilaurate