title: [Influence of hepatitis C virus infection and human immunodeficiency on the natural history of chronic delta hepatitis].
abstract: OBJECTIVE
  To analyze the prevalence and clinical significance of HCV an HIV infections among a group of patients with chronic delta hepatitis.
  
  
  METHODS
  We have studied the clinical and the histological activity and the serological profile the HBV DNA was analyzed by dot blot and PCR and the HDV RNA by dot blot) in 46 patients with chronic delta hepatitis. These results were correlated with HCV infection (assessed by ELISA-2, RIBA-2 and RT-PCR) and HIV infection (ELISA and immunoblot).
  
  
  RESULTS
  HBV DNA and HDV RNA was detected by dot in 28.2% and 71.4% of patients respectively, and by PCR, 89.1% of patients had HBV DNA in their serum. Twenty two of 46 patients with chronic delta hepatitis were anti-HCV positives (with HCV RNA detectable in sera by RT-PCR in 19 cases). Anti-HIV positivity was detected in 19 of 46 patients. The mean aminotransferase level, histological activity and serological profile was similar in the anti-HCV positive and negative patients. Likewise, clinical and histological activity and serological profile was similar in the anti-HIV positive and negative patients.
  
  
  CONCLUSIONS
  Concomitant infection with HCV or HIV does not seem to significantly modify the clinical course of chronic delta hepatitis. In addition, no significant serological difference has been noted in patients with chronic delta hepatitis with anti-HIV or anti-HCV antibodies.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario, Marqués de Valdecilla.
authors.forename: J
authors.initials: J
authors.lastname: Crespo
authors.forename: J L
authors.initials: JL
authors.lastname: Lozano
authors.forename: S
authors.initials: S
authors.lastname: Echevarría
authors.forename: G
authors.initials: G
authors.lastname: San Miguel
authors.forename: E
authors.initials: E
authors.lastname: Artiñano
authors.forename: M J
authors.initials: MJ
authors.lastname: López Arias
authors.forename: F
authors.initials: F
authors.lastname: Pons Romero
mesh_terms: D000328:Adult; D001483:Base Sequence; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology; D003699:Hepatitis D / Q000097:blood / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016036:Seroepidemiologic Studies
chemical_list: D015483:HIV Antibodies; D006508:Hepatitis Antibodies
vernacular_title: Influencia de la infección por los virus de la hepatitis C y de la inmunodeficiencia humana en la historia natural de la hepatitis crónica delta.