Study on carcinogenicity of clinoptilolite type zeolite in Wistar rats.
The long term carcinogenicity of clinoptilolite was examined in Wistar rats. Respirable clinoptilolite was given intratracheally in doses 0, 30, or 60 mg/animal to groups of 60 or 50 male and 50 female rats on one occasion. No significant dose-related increase was found in the incidence of tumours in any organ or tissue. The results indicated that clinoptilolite type zeolite had no carcinogenic activity in Wistar rats.
Tátrai
E
E
National Institute of Occupational Health, Budapest, Hungary.
Ungváry
G
G
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D017641:Zeolites / Q000008:administration & dosage / Q000633:toxicity*
C083175:clinoptilolite; D017641:Zeolites