Antitumor effect of biological response modifier, PSK, on C57BL/6 mice with syngeneic melanoma B16 and its mode of action.
The effects of PSK, a protein-bound polysaccharide, on the survival period and effector cell activity were examined using C57BL/6 mice with melanoma B16. PSK prolonged the survival period of the mice with tumors in a schedule- and dose-dependent manner. However, no life-prolonging effect was observed when carrageenan-treated mice or congenitally athymic mice were used as hosts. PSK enhanced the cytostatic activity and interleukin-1-producing capacity of peritoneal exudate plastic-adherent cells in C57BL/6 mice with tumors. These findings suggested that PSK prolongs the survival period of mice with B16 tumors through T-cell- and macrophage-dependent mechanisms.
Matsunaga
K
K
Biomedical Research Laboratories, Kureha Chemical Industry Co., Tokyo, Japan.
Aota
M
M
Nyunoya
Y
Y
Hakozaki
M
M
Ishikawa
Y
Y
Ohhara
M
M
Sugita
N
N
Endo
H
H
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001483:Base Sequence; D004334:Drug Administration Schedule; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage*; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism; D008546:Melanoma, Experimental / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000008:administration & dosage*; D015996:Survival Rate; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D007155:Immunologic Factors; D007375:Interleukin-1; D011509:Proteoglycans; C010770:polysaccharide-K