Relationship between lung tissue and blood plasma concentrations of inhaled budesonide.
In 11 patients, in whom a lung lobe or whole lung was to be resected, a single dose of 1.6 mg inhaled budesonide was given pre-operatively. In 9 of them, concentrations of the drug in both lung tissue and blood plasma were measured. Budesonide concentrations in lung tissue, at least 90 min after dosage, were 2.1-8.9 nmol kg-1. Concentrations in blood plasma (0.27-1.1 nmol kg-1) were 1/8th of those in lung tissue.
Van den Bosch
J M
JM
Department of Chest Diseases, St. Antonius Hospital, Nieuwegein, The Netherlands.
Westermann
C J
CJ
Aumann
J
J
Edsbäcker
S
S
Tönnesson
M
M
Selroos
O
O
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000368:Aged; D019819:Budesonide; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011282:Pregnenediones / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000336:Aerosols; D005938:Glucocorticoids; D011282:Pregnenediones; D019819:Budesonide