Graft-versus-leukemia effect in allogeneic bone marrow transplantation in mice against several radiation-induced leukemias.
The intensity of graft-versus-leukemia (GVL) effect was studied using several radiation-induced leukemia cell lines (designated 8027, 8313, 9107, 7929) in MHC-compatible and -incompatible allogeneic bone marrow transplantation (BMT) of leukemia-bearing C3H mice. The results indicated that BMT from MHC-incompatible allogeneic (B10, B10.D2) donors consistently improved the survival of the treated mice compared with that in syngeneic (C3H) donors. However, BMT from MHC-compatible allogeneic (B10.BR, CBA, AKR) donors failed to improve the survival of 8027-bearing recipients. On the other hand, a remarkable improvement in survival of 8313, 9107 or 7929-bearing recipients was observed in MHC-compatible allogeneic (B10.BR, AKR) BMT but there was only a marginal GVL effect in MHC-compatible BMT from CBA donors. There was no clear correlation between the intensity of GVL effect and the amount of class I MHC molecules expressed on leukemic cell lines. The activity of donor lymph node cells for the induction of lethal graft-versus-host disease (GVHD) correlated with the intensity of GVL effect induced by intact donor bone marrow. The results indicate that GVL effect against radiation-induced leukemias could be consistently induced in MHC-incompatible allogeneic BMT whereas the intensity of GVL effect induced in MHC-compatible allogeneic BMT varied among different leukemias and the donor-host strain combinations used.
Aizawa
S
S
Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.
Sado
T
T
Kamisaku
H
H
Nemoto
K
K
Yoshida
K
K
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000473:pathology; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D015994:Incidence; D007942:Leukemia, Experimental / Q000453:epidemiology / Q000276:immunology*; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D012008:Recurrence; D016019:Survival Analysis; D014184:Transplantation, Homologous
D015395:Histocompatibility Antigens Class I