Oncogenic activation of tyrosine kinases.
Tyrosine kinases comprise the largest group of oncoproteins, a fact that underscores the importance of reversible tyrosine phosphorylation in the regulation of essential cellular functions. Oncogenic activation of tyrosine kinases results in the constitutive activation of what is normally a conditionally regulated enzyme activity. Studies of tyrosine kinase oncoproteins, and a comparison with their corresponding proto-oncogene products, have identified important functional and regulatory domains within these proteins, positive and negative regulators of their enzyme activities and signalling cascades that control cell growth and differentiation.
Rodrigues
G A
GA
McGill University, Montreal, Canada.
Park
M
M
D000818:Animals; D000081247:CSK Tyrosine-Protein Kinase; D004789:Enzyme Activation / Q000235:genetics; D006801:Humans; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D019061:src-Family Kinases
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases; C000631346:CSK protein, human