Antitumor-promoting activity of mallotojaponin, a major constituent of pericarps of Mallotus japonicus.
Mallotojaponin, a major constituent of the pericarps of Mallotus japonicus (Euphorbiaceae), inhibited the action of tumor promoter in vitro and in vivo; it inhibited tumor promoter-enhanced phospholipid metabolism in cultured cells, and also suppressed the promoting effect of 12-O-tetradecanoylphorbol-13-acetate on skin tumor formation in mice initiated with 7,12-dimethylbenz-[a]anthracene.
Satomi
Y
Y
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Arisawa
M
M
Nishino
H
H
Iwashima
A
A
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010743:Phospholipids / Q000096:biosynthesis; D010936:Plant Extracts / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D010743:Phospholipids; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene; C070199:mallotojaponin; D010696:Phloroglucinol; D013755:Tetradecanoylphorbol Acetate