title: A case report of drug-induced allergic hepatitis probably due to the N-methyltetrazolethiol group cephalosporin.
abstract: Drug-induced allergic hepatitis occurred in a patient being treated with cefpiramide sodium. A lymphocyte blast transformation test suggested that the N-methyltetrazolethiol group of the drug was responsible for the induction of acute hepatitis. A detailed case report and discussion of the relevant literature are presented in this paper.
authors.affiliation: Third Department of Internal Medicine, Ehime University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Kojima
authors.forename: I
authors.initials: I
authors.lastname: Kumamoto
authors.forename: T
authors.initials: T
authors.lastname: Masumoto
authors.forename: M
authors.initials: M
authors.lastname: Onji
mesh_terms: D000208:Acute Disease; D000328:Adult; D002511:Cephalosporins / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects
chemical_list: D002511:Cephalosporins; C036666:cefpiramide