title: Humanized antibodies.
abstract: Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering, reviewed her by Greg Winter and William Harris, is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.
authors.affiliation: Laboratory of Molecular Biology, MRC Centre for Protein Engineering, Cambridge, UK.
authors.forename: G
authors.initials: G
authors.lastname: Winter
authors.forename: W J
authors.initials: WJ
authors.lastname: Harris
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology; D003198:Computer Simulation; D005803:Genes, Immunoglobulin / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D015202:Protein Engineering; D017434:Protein Structure, Tertiary
chemical_list: D000911:Antibodies, Monoclonal