The major histocompatibility complex in man.
The HLA system is a complex of polymorphic genes divided into a class I group and a class II group. The disclosed tertiary structure of HLA antigens indicates that they are principally involved in binding a variety of self and foreign immunogenic peptides and in their presentation to T cells. Class III HLA region is located between class I and class II regions. It comprises many genes, some of them participate in events of the immune response, too.
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Department of Immunology, Faculty of Medicine, Comenius University, Bratislava.
D017951:Antigen Presentation / Q000276:immunology; D005075:Biological Evolution; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology*; D017434:Protein Structure, Tertiary; D018089:Superantigens / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D018089:Superantigens