title: Nucleotide sequence of the Escherichia coli K12 histidine operon revisited.
abstract: We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.
authors.forename: G
authors.initials: G
authors.lastname: Jovanović
authors.forename: T
authors.initials: T
authors.lastname: Kostić
authors.forename: M
authors.initials: M
authors.lastname: Janković
authors.forename: D J
authors.initials: DJ
authors.lastname: Savić
mesh_terms: D001483:Base Sequence; D004926:Escherichia coli / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D006639:Histidine / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009876:Operon / Q000235:genetics*; D012486:Salmonella typhimurium / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D006639:Histidine