title: Sympathetic denervation and the cerebrovascular response to hypertension induced by NG-nitro-L-arginine methyl ester.
abstract: Cerebral blood flow and glucose utilization were measured in rat neocortex, using [14C]iodoantipyrine and 2-deoxy-D-[14C]glucose quantitative autoradiography, respectively, following nitric oxide synthesis inhibition with L-NAME. In intact animals cortical blood flow was decreased, despite increased arterial blood pressure above autoregulatory limits, whilst glucose use remained unaffected. Unilateral sympathectomy at the superior cervical ganglion had no effect, suggesting that the autoregulatory response to L-NAME-induced hypertension is independent of sympathetic activity.
authors.affiliation: Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Kelly
authors.forename: C L
authors.initials: CL
authors.lastname: Thomas
authors.forename: I M
authors.initials: IM
authors.lastname: Ritchie
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives*; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D051381:Rats; D017207:Rats, Sprague-Dawley; D013562:Sympathectomy
chemical_list: D009569:Nitric Oxide; D001120:Arginine; D005947:Glucose; D019331:NG-Nitroarginine Methyl Ester