title: Steroid hormones and Tourette's syndrome: early experience with antiandrogen therapy.
abstract: We report here the first use in Tourette's syndrome of the nonsteroidal androgen receptor blocking agent flutamide. One man and one woman underwent open trials of the medication, and a second man participated in a placebo-controlled, double-blind crossover trial. Improvement in tic symptoms ranged from 45 to 60%. The improvement was sustained in the woman during daily flutamide use and in one man during its intermittent use. One man's symptoms became refractory to treatment after 5 weeks of flutamide use, whereas the woman became depressed and had protracted diarrhea during her treatment.
authors.affiliation: Yale Child Study Center, New Haven, CT 06520-7009.
authors.forename: B S
authors.initials: BS
authors.lastname: Peterson
authors.forename: J F
authors.initials: JF
authors.lastname: Leckman
authors.forename: L
authors.initials: L
authors.lastname: Scahill
authors.forename: F
authors.initials: F
authors.lastname: Naftolin
authors.forename: D
authors.initials: D
authors.lastname: Keefe
authors.forename: N J
authors.initials: NJ
authors.lastname: Charest
authors.forename: R A
authors.initials: RA
authors.lastname: King
authors.forename: M T
authors.initials: MT
authors.lastname: Hardin
authors.forename: D J
authors.initials: DJ
authors.lastname: Cohen
mesh_terms: D000328:Adult; D005260:Female; D005485:Flutamide / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005879:Tourette Syndrome / Q000188:drug therapy*
chemical_list: D005485:Flutamide