Effect of thyroxine on DNA methyltransferase activity in cerebellum of rat.
DNA methyltransferase activity increased significantly in cerebellum from day 4 to day 8 and decreased in 30 day old rats. It was maintained at lower levels in the adult rats. Thyroxine administration markedly stimulated DNA methyl- transferase activity in the newly born pups. However, it did not cause any effect on this enzyme activity in 8 day old rat cerebellum. These results show that thyroxine has a role in the regulation of DNA methyltransferase activity in cerebellum of rat during early stages of development.
Reddy
P M
PM
School of Life Sciences, University of Hyderabad, India.
Reddy
P R
PR
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D015254:DNA Modification Methylases / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology*
D015254:DNA Modification Methylases; D013974:Thyroxine