title: Study on carcinogenicity of clinoptilolite type zeolite in Wistar rats.
abstract: The long term carcinogenicity of clinoptilolite was examined in Wistar rats. Respirable clinoptilolite was given intratracheally in doses 0, 30, or 60 mg/animal to groups of 60 or 50 male and 50 female rats on one occasion. No significant dose-related increase was found in the incidence of tumours in any organ or tissue. The results indicated that clinoptilolite type zeolite had no carcinogenic activity in Wistar rats.
authors.affiliation: National Institute of Occupational Health, Budapest, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Tátrai
authors.forename: G
authors.initials: G
authors.lastname: Ungváry
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D017641:Zeolites / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: C083175:clinoptilolite; D017641:Zeolites