Practical aspects of 3,4-diaminopyridine treatment of the Lambert-Eaton myasthenic syndrome.
3,4-Diaminopyridine (3,4-DAP) given alone or combined with pyridostigmine is the recommended basic therapy in the Lambert-Eaton myasthenic syndrome (LEMS). We present and exemplify our routine test protocol for monitoring drug introduction and treatment regimen of cholinergic drugs in LEMS. The individual drug responses vary and no recommended standard doses exist. Routine electrophysiological repetitive nerve stimulation studies recording amplitude of initial compound muscle action potential (CMAP) in thenar muscles correlate excellently with clinical myasthenic muscle power tests in clinically affected muscle groups. Therefore repetitive clinical muscle power tests, that often are complicated by painful myalgia and activation potentiation, can be replaced by recordings of CMAP in the introduction and clinical follow up of cholinergic drug treatment in LEMS. Also, adverse effects and other treatment problems from the experience of continuous treatment of 19 LEMS patients with 3,4-DAP for up to 10 years are presented.
Lundh
H
H
Department of Neurology, Halmstad Hospital, Stockholm, Sweden.
Nilsson
O
O
Rosén
I
I
Johansson
S
S
D015761:4-Aminopyridine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000077770:Amifampridine; D002985:Clinical Protocols; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects; D009369:Neoplasms / Q000378:metabolism; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011729:Pyridostigmine Bromide / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use
D010277:Parasympathomimetics; D015761:4-Aminopyridine; D011729:Pyridostigmine Bromide; D000077770:Amifampridine