HIV and human complement: mechanisms of interaction and biological implication.
Human complement, although not lytic for HIV-1, interacts with the virus and is closely involved in the infectious process. It enhances infection in the absence of antibody, and turns neutralizing antibodies into agents which increase viral infectivity. In this review M.P. Dierich et al. summarize available information and discuss possible biological implications.
Dierich
M P
MP
Institut für Hygiene, Leopold Franzens Universität, Innsbruck, Austria.
Ebenbichler
C F
CF
Marschang
P
P
Füst
G
G
Thielens
N M
NM
Arlaud
G J
GJ
D000818:Animals; D003167:Complement Activation / Q000276:immunology; D015941:Complement Hemolytic Activity Assay; D003165:Complement System Proteins / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
D015483:HIV Antibodies; D003165:Complement System Proteins