title: A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction.
abstract: We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N-terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart.
authors.affiliation: Department of Zoology, Graduate School of Neurosciences Amsterdam, Vrije Universiteit, Faculty of Biology, The Netherlands.
authors.forename: C P
authors.initials: CP
authors.lastname: Tensen
authors.forename: E R
authors.initials: ER
authors.lastname: Van Kesteren
authors.forename: R J
authors.initials: RJ
authors.lastname: Planta
authors.forename: K J
authors.initials: KJ
authors.lastname: Cox
authors.forename: J F
authors.initials: JF
authors.lastname: Burke
authors.forename: H
authors.initials: H
authors.lastname: van Heerikhuizen
authors.forename: E
authors.initials: E
authors.lastname: Vreugdenhil
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008195:Lymnaea; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011973:Receptors, LDL / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D008077:Lipoproteins, LDL; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D004247:DNA; D019204:GTP-Binding Proteins