[The immunological phenotype and proliferative activity of the tumor lymphocytes in multiple myeloma].
An immunological phenotype of blood lymphocytes and proliferative activity of tumor cells were studied using a panel of monoclonal antibodies to lymphocyte differential antigens and tracer 3H-thymidine, respectively, in 84 patients with multiple myeloma. CD-19 and CD38 antigens were identified as markers for circulating tumor lymphocytes. The count of CD38+ and CD71+lymphocytes correlated with the count of marrow plasmocytes including 3H-thymidine in the disease recurrence. Proliferative parameters of blood lymphocytes, plasmocytes and lymphocytes of the bone marrow were identical being, consequently, elements of the same tumor clone.
Golenkov
A K
AK
Nazarova
I N
IN
Sarycheva
T G
TG
Miterev
G Iu
GIu
Kozinets
G I
GI
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D001345:Autoradiography; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002455:Cell Division / Q000276:immunology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology; D012008:Recurrence; D012074:Remission Induction
D015703:Antigens, CD
Immunologicheskiĭ fenotip i proliferativnaia aktivnost' opukholevykh limfotsitov pri mnozhestvennoĭ mielome.