title: Exercise-induced rhabdomyolysis.
abstract: OBJECTIVE
  To describe the syndrome of exercise-induced rhabdomyolysis and to investigate the relation between exercise-induced rhabdomyolysis and the development of acute renal failure.
  
  
  METHODS
  Retrospective chart analysis on all patients with a discharge diagnosis of rhabdomyolysis from January 1988 to January 1993.
  
  
  METHODS
  An urban tertiary care center with 225,000 annual emergency department visits.
  
  
  METHODS
  Thirty-five patients met the inclusion criteria for exercise-induced rhabdomyolysis: a history of strenuous exercise, creatine phosphokinase level more than 500, and urine dipstick positive for blood without hematuria. We excluded patients with a history of trauma, myocardial infarction, stroke, or documented sepsis. Charts also were examined for the presence of nephrotoxic cofactors (ie, hypovolemia and/or acidosis).
  
  
  RESULTS
  All 35 patients were men without significant past medical history and were an average age of 24.4 years. The average admission creatine phosphokinase was 40,471 U/L. No patient presented with or developed nephrotoxic cofactors during hospitalization. None of our study patients experienced acute renal failure.
  
  
  CONCLUSIONS
  Previous literature has described a 17% to 40% incidence of acute renal failure in rhabdomyolysis. None of our patients developed acute renal failure, signifying a much lower incidence of acute renal failure in exercise-induced rhabdomyolysis without nephrotoxic cofactors than in other forms of rhabdomyolysis.
authors.affiliation: Department of Emergency Medicine, State University of New York Health Science Center, Brooklyn/Kings County Hospital Center.
authors.forename: R
authors.initials: R
authors.lastname: Sinert
authors.forename: L
authors.initials: L
authors.lastname: Kohl
authors.forename: T
authors.initials: T
authors.lastname: Rainone
authors.forename: T
authors.initials: T
authors.lastname: Scalea
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000652:urine; D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D004636:Emergency Service, Hospital; D015444:Exercise; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000652:urine; D012307:Risk Factors
chemical_list: D003402:Creatine Kinase