title: In vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis.
abstract: We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This result correlated with the observed therapeutic efficacies of the quinolones.
authors.affiliation: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, UCLA School of Medicine 90059.
authors.forename: S V
authors.initials: SV
authors.lastname: Gollapudi
authors.forename: S K
authors.initials: SK
authors.lastname: Chuah
authors.forename: T
authors.initials: T
authors.lastname: Harvey
authors.forename: H D
authors.initials: HD
authors.lastname: Thadepalli
authors.forename: H
authors.initials: H
authors.lastname: Thadepalli
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001441:Bacteroides fragilis; D016516:CD4-CD8 Ratio / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology*; D005260:Female; D024841:Fluoroquinolones; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*; D013154:Spleen / Q000033:anatomy & histology / Q000187:drug effects; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D014409:Tumor Necrosis Factor-alpha; D002939:Ciprofloxacin; C060328:rufloxacin