title: Prior blood transfusions and Alzheimer's disease.
abstract: We performed a population-based, case-control study to evaluate prior blood transfusion as a potential risk factor for Alzheimer's disease (AD). All cases were incident cases of AD from 1975 to 1984 with residence for 40 years or more in Olmsted County, Minnesota, prior to their onset of dementia (N = 252). There was one age- and gender-matched control for each case. We ascertained the number of blood transfusions prior to the age of onset of dementia and the corresponding year in each control. Sixty-five cases and 55 controls had at least one prior blood transfusion. We did not find a significantly increased risk of AD for the events of at least one, three, or six blood transfusions.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905.
authors.forename: N I
authors.initials: NI
authors.lastname: Bohnen
authors.forename: M A
authors.initials: MA
authors.lastname: Warner
authors.forename: E
authors.initials: E
authors.lastname: Kokmen
authors.forename: C M
authors.initials: CM
authors.lastname: Beard
authors.forename: L T
authors.initials: LT
authors.lastname: Kurland
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000209:etiology; D001803:Blood Transfusion; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D012307:Risk Factors