Acetylator polymorphism in multiple sclerosis.
To elucidate whether any relationship exists between genetic polymorphic acetylation and the risk for multiple sclerosis (MS), we determined this polymorphism, using sulphamethazine, in 71 patients with definite MS and in 268 age-matched controls. Thirty-seven patients (52.1%) and 151 controls (56.3%) were classified as slow acetylators (not significant difference). No relation was found between acetylator polymorphism and age at onset of disease in MS patient's group. Our results do not support the existence of any relationship between acetylator polymorphism and the risk for MS.
Ladero
J M
JM
Gastroenterology Service, Hospital Universitario San Carlos, University Complutense, Department of Medicine, Madrid, Spain.
Arroyo
R
R
De Andrés
C
C
Jiménez-Jiménez
F J
FJ
Molina
J A
JA
Varela de Seijas
E
E
Giménez-Roldán
S
S
Benítez
J
J
D000107:Acetylation; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013418:Sulfamethazine
D013418:Sulfamethazine