A comparison of the effect of propofol or thiopentone on the incidence and severity of suxamethonium-induced myalgia.
We conducted a prospective, randomised single-blind study in 48 adult women undergoing laparoscopic gynaecological surgery to assess the incidence of suxamethonium-induced myalgia. Anaesthesia was induced with either thiopentone or propofol. All other aspects of clinical care were standardised between the groups. The propofol group had a significantly lower incidence of suxamethonium myalgia (19%) compared with the thiopentone group (63%) (P < 0.05). The mechanism of this effect is not understood.
McClymont
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Department of Anaesthesia, Christchurch Hospital, New Zealand.
D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D005260:Female; D005836:Genitalia, Female / Q000601:surgery; D006801:Humans; D015994:Incidence; D010535:Laparoscopy; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010146:Pain / Q000139:chemically induced* / Q000503:physiopathology; D010147:Pain Measurement; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D016037:Single-Blind Method; D013390:Succinylcholine / Q000009:adverse effects*; D013874:Thiopental / Q000494:pharmacology*
D013390:Succinylcholine; D013874:Thiopental; D015742:Propofol