title: Appearance of neuropeptide Y-like immunoreactive cells in the rat trigeminal ganglion following dental injuries.
abstract: The effects of these injuries on the presence and distribution of neuropeptide Y (NPY)-immunoreactive (-IR) neurones were examined immunohistochemically. In the normal trigeminal ganglion: some perivascular nerves displayed NPY-IR but there were no NPY-IR ganglionic cells. Fourteen days after extraction or pulp exposure of the upper first molar, NPY-IR cells appeared in the maxillary region of the trigeminal ganglion. About 90% of the injury-evoked NPY-IR cells had medium to large diameters (more than 300 microns2 in cross-sectional area). Shallow cavity preparation, however, did not induce the appearance of NPY-IR cells in the trigeminal ganglion. These results indicate the dental injuries alter the primary sensory neurones in the trigeminal ganglion.
authors.affiliation: Department of Operative Dentistry, Osaka University Faculty of Dentistry, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Itotagawa
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
authors.forename: S
authors.initials: S
authors.lastname: Wakisaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Kurisu
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuchitani
mesh_terms: D000818:Animals; D003737:Dental Cavity Preparation / Q000009:adverse effects; D003782:Dental Pulp / Q000293:injuries* / Q000294:innervation; D003789:Dental Pulp Exposure / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000473:pathology; D009478:Neuropeptide Y / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014081:Tooth Extraction / Q000009:adverse effects; D012668:Trigeminal Ganglion / Q000737:chemistry / Q000293:injuries* / Q000473:pathology
chemical_list: D009478:Neuropeptide Y