Aluminum in the neonate related to parenteral nutrition.
Sources of aluminium loading and exposure in preterm and full-term newborns were studied. Parenteral nutrition solutions were the main source of aluminium representing 88.7% of total aluminium intake. Blood and urine aluminium levels were followed over a 28-day period in a group of 26 preterm and 9 term infants while receiving parenteral nutrition (duration 15.6 +/- 8.7 days) and later when being formula fed. Urine levels were followed up to 13 weeks in a subgroup of the neonates. Serum aluminium levels (0.86 +/- 0.38 mumol/l) and urine aluminium/creatinine ratio (1.52 +/- 0.81 mumol/mmol) were increased when the infants were receiving parenteral nutrition compared with the control group (p < 0.001). The urine aluminium/creatinine ratio remained high up to 10 weeks following withdrawal of parenteral nutrition and suggested tissular loading. This was confirmed after high aluminium levels were found in post-mortem brain and bone samples from two preterm and one full-term infant. We conclude that both preterm and full-term neonates are susceptible to accumulation of aluminium in tissue while receiving parenteral nutrition.
Moreno
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Paediatric Intensive Care Unit, Children's Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain.
Domínguez
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Ballabriga
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D000535:Aluminum / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001842:Bone and Bones / Q000737:chemistry; D001923:Brain Chemistry; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D010288:Parenteral Nutrition / Q000009:adverse effects*
D000535:Aluminum