title: Antimicrobial and antitumoral activities of 6-allyl-5,6-dihydro-5-hydroxypyran-2-one, a lactone produced by a new Drechslera species.
abstract: Antifungal, antibacterial and antitumoral properties of 6-allyl-5,6-dihydro-5-hydroxypyran-2-one were researched. This compound was isolated from culture medium of a new Drechslera species from the area of the Dead Sea. The product exhibited a large activity spectrum against microorganisms, with interesting IC 50 values close to those obtained with reference compounds (kanamycin and ketoconazole). Antitumoral potentiality was 10 to 58 times less important than with doxorubicin, however IC 50 obtained were below 4 micrograms/ml, which is the threshold value proposed by National Cancer Institute for preliminary screening of active molecules.
authors.affiliation: Groupe pour l'Etude du Devenir des Xénobiotiques dans l'Environnement (GEDEXE), UFR Pharmacie, Meylan, France.
authors.forename: P
authors.initials: P
authors.lastname: Guiraud
authors.forename: R
authors.initials: R
authors.lastname: Steiman
authors.forename: F
authors.initials: F
authors.lastname: Seigle-Murandi
authors.forename: M H
authors.initials: MH
authors.lastname: Bartoli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000378:metabolism*; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: C087367:6-allyl-5,6-dihydro-5-hydroxypyran-2-one; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; D007654:Ketoconazole