Repeated exposure to the polychlorinated biphenyl (Aroclor 1254) elevates the basal serum levels of corticosterone but does not affect the stress-induced rise.
Previous studies indicate that repeated exposure of weanling male Fischer 344 rats to Aroclor can cause immune system alterations but the pattern of effects suggested the release of corticosteroids may have played a role. Rats were exposed daily by gastric intubation to the polychlorinated biphenyl (PCB) Aroclor 1254 at 0.1, 1.0, 10, or 25 mg/kg for exposure durations of 5, 10 or 15 weeks. By the 15th week of dosing all groups displayed an elevation in the basal level of serum corticosterone but no change in adrenal weight. Further, rats exposed to Aroclor 1254 for 15 weeks and subjected to stress prior to serum collection displayed elevations in corticosterone levels equivalent to stressed control rats. The failure to observe altered adrenal structure indicative of hyperactivity in the presence of increased serum levels of corticosterone suggest these basal increases may be indirect rather than direct effects of Aroclor 1254.
Miller
D B
DB
Health Effects Research Laboratory, USEPA, NC 27711.
Gray
L E
LE
Andrews
J E
JE
Luebke
R W
RW
Smialowicz
R J
RJ
D000818:Animals; D001140:Aroclors / Q000008:administration & dosage / Q000494:pharmacology*; D002273:Carcinogens / Q000008:administration & dosage / Q000494:pharmacology*; D020111:Chlorodiphenyl (54% Chlorine); D003345:Corticosterone / Q000097:blood*; D004334:Drug Administration Schedule; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013312:Stress, Physiological / Q000097:blood
D001140:Aroclors; D002273:Carcinogens; D020111:Chlorodiphenyl (54% Chlorine); D003345:Corticosterone