A fatal case of scleredema of Buschke.
Scleredema of Buschke is a rare disorder characterized by the development of areas of skin induration which usually resolve spontaneously. It is occasionally associated with a benign gammopathy, and rarely with myelomatosis. We describe a 60-year-old woman with extensive skin changes, who developed IgA myeloma. Unusually, her skin disease did not respond to conventional myeloma therapy. Death occurred as a consequence of the progressive skin disease.
Sansom
J E
JE
Department of Dermatology, Bristol Royal Infirmary, U.K.
Sheehan
A L
AL
Kennedy
C T
CT
Delaney
T J
TJ
D004947:Esophagus / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007421:Intestine, Small / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000401:mortality; D012592:Scleredema Adultorum / Q000150:complications* / Q000401:mortality / Q000473:pathology
D007070:Immunoglobulin A