title: Vascularization of primary central nervous system tumors: detection with contrast-enhanced transcranial color-coded real-time sonography.
abstract: OBJECTIVE
  To study the potential of contrast material-enhanced transcranial color-coded real-time sonography (TCCS) in detection of primary intracranial tumor vascularization.
  
  
  METHODS
  Primary central nervous system (CNS) tumors in 28 patients were examined with TCCS before and during administration of a transpulmonary, stable, galactose, microparticle-based ultrasound (US) contrast agent. All patients underwent cranial computed tomography and magnetic resonance imaging; nine patients also underwent intraarterial digital subtraction angiography.
  
  
  RESULTS
  All lesions were hyperechoic on B-mode US scans except one grade 2 astrocytoma. The location and extent of hyperechoic lesions correlated well with findings on CT scans and MR images. After injection of contrast material, color Doppler flow signals were seen in nine of 14 low-grade lesions and 14 of 14 high-grade lesions. High-grade malignant tumors always had atypical arterial and venous Doppler spectra with irregular distribution of Doppler shift and signal intensities; these atypical flow patterns were also detected in some low-grade tumors.
  
  
  CONCLUSIONS
  In addition to depiction of primary CNS tumors in B-mode, contrast-enhanced TCCS enables evaluation of vascularization associated with tumor parenchyma.
authors.affiliation: Department of Neurology, University of Würzburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Bogdahn
authors.forename: T
authors.initials: T
authors.lastname: Fröhlich
authors.forename: G
authors.initials: G
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Krone
authors.forename: R
authors.initials: R
authors.lastname: Schlief
authors.forename: J
authors.initials: J
authors.lastname: Schürmann
authors.forename: P
authors.initials: P
authors.lastname: Jachimczak
authors.forename: E
authors.initials: E
authors.lastname: Hofmann
authors.forename: W
authors.initials: W
authors.lastname: Roggendorf
authors.forename: K
authors.initials: K
authors.lastname: Roosen
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508