title: Dissemination of low grade intracranial astrocytomas in children.
abstract: The authors report three cases of histologically benign intracranial astrocytomas that developed in children and disseminated within the neuraxis. Multicentric disease was evident at the time of diagnosis in two of these patients, one of whom subsequently developed peritoneal seeding of tumor after placement of a ventriculoperitoneal shunt. To our knowledge, this latter represents the first documented case of extraneural seeding of a benign astrocytoma. All three children are currently alive and well 17-117 months after the diagnosis of tumor dissemination. We review the literature regarding this uncommon problem and discuss the pathophysiology and treatment options. Our results indicate that the presence of disseminated disease may not preclude long term survival, provided the lesions are truly benign histologically and that adjuvant therapy is instituted promptly.
authors.affiliation: Department of Neurosurgery, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, PA 15213.
authors.forename: I F
authors.initials: IF
authors.lastname: Pollack
authors.forename: M
authors.initials: M
authors.lastname: Hurtt
authors.forename: D
authors.initials: D
authors.lastname: Pang
authors.forename: A L
authors.initials: AL
authors.lastname: Albright
mesh_terms: D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009362:Neoplasm Metastasis; D009366:Neoplasm Seeding; D014057:Tomography, X-Ray Computed