title: [Brain morphometry using MRI in Cri-du-Chat Syndrome. Report of seven cases with review of the literature].
abstract: The authors present the results of a morphometric study of the brain of 7 patients with cat cry syndrome, explored with Magnetic Resonance Imaging (MRI). A method is proposed in order to facilitate the identification of the anatomical slices. A characteristic anomaly is observed as a marked atrophy of the brainstem predominating at the pontine level and associated with a small cerebellum, atrophic middle cerebellar peduncles and cerebellar white matter. This apparently systematized atrophy obvious in children, seems similar to the one observed in patients presenting a olivopontocerebellar atrophy, possibly correlating with disturbance of coordination and developmental delay in motility as observed in these patients. This does not implicate the same subjacent functional neuroanatomical pathways.
authors.affiliation: Service de Neuroradiologie et d'lRM, Hôtel-Dieu de France, Université Saint-Joseph de Beyrouth, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Tamraz
authors.forename: M O
authors.initials: MO
authors.lastname: Rethoré
authors.forename: J
authors.initials: J
authors.lastname: Lejeune
authors.forename: C
authors.initials: C
authors.lastname: Outin
authors.forename: R
authors.initials: R
authors.lastname: Goepel
authors.forename: J L
authors.initials: JL
authors.lastname: Stievenart
authors.forename: M T
authors.initials: MT
authors.lastname: Iba-Zizen
authors.forename: E A
authors.initials: EA
authors.lastname: Cabanis
mesh_terms: D000293:Adolescent; D000328:Adult; D001699:Biometry; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D008297:Male
vernacular_title: Morphométrie encéphalique en irm dans la maladie du chat. A propos de sept patients, avec revue de la littérature. Association pour la recherche sur la sclérose en plaques.