title: Structural proteins of avian infectious bronchitis virus: role in immunity and protection.
abstract: The antigenicity of the S1, M and N proteins of avian infectious bronchitis virus was compared following immunization of chickens with live and inactivated virus. The N protein was immunodominant antigen inducing cross-reactive antibodies in high titres whereas the S1 glycoprotein induced serotype-specific and cross-reactive antibodies. The M glycoprotein elicited antibodies in low titres and of limited cross-reactivity. Immunization of chickens with the purified N and M proteins did not induce protection against virulent challenge whereas immunization with the S1 glycoprotein prevented replication of nephropathogenic IBV in kidneys but not in tracheas of immunized chickens.
authors.affiliation: CSIRO Division of Animal Health, Parkville, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Ignjatovic
authors.forename: L
authors.initials: L
authors.lastname: Galli
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D001991:Bronchitis / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D002213:Capsid / Q000276:immunology; D002645:Chickens / Q000276:immunology; D018352:Coronavirus Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D000086862:Coronavirus M Proteins; D003429:Cross Reactions; D007114:Immunization; D001351:Infectious bronchitis virus / Q000276:immunology*; D007674:Kidney Diseases / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D008562:Membrane Glycoproteins / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D064370:Spike Glycoprotein, Coronavirus; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D014758:Viral Core Proteins / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology; D014763:Viral Matrix Proteins / Q000276:immunology; D015678:Viral Structural Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D000086862:Coronavirus M Proteins; C000706230:M protein, Avian infectious bronchitis virus; D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; D014763:Viral Matrix Proteins; D015678:Viral Structural Proteins; D014765:Viral Vaccines