Cutaneous late-phase reaction to environmental antigen in patients with atopic dermatitis.
Intradermal testing with 7 environmental allergens was performed on 71 patients with atopic dermatitis (AD) with respiratory atopy (RAT) and 30 pure AD patients, and the cutaneous late-phase reaction (CLPR) was observed several to 48 h after challenge. CLPR was not seen in pure AD. In AD patients with RAT, CLPR was positive in 29 of 71 patients. No macroscopic eczematous lesions appeared. All CLPR-positive patients showed RAST scores of 2 or more. We assume that CLPR can be an exacerbating factor in AD with RAT, while it is not directly involved in pure AD.
Oyama
K
K
Oyama Dermatological Clinic, Tokyo, Japan.
D000293:Adolescent; D000328:Adult; D000485:Allergens; D000818:Animals; D002415:Cats; D003876:Dermatitis, Atopic / Q000276:immunology*; D004285:Dogs; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008925:Mites; D011058:Pollen; D011852:Radioallergosorbent Test; D012867:Skin / Q000276:immunology; D012882:Skin Tests
D000485:Allergens; D007073:Immunoglobulin E