[The neutrophil antibacterial function of patients with chronic bronchitis. Its immune correction by using inflammatory cytokines and allogeneic lymphocytes in vitro].
In patients with acute and chronic bronchitis decreased neutrophil phagocytic, induced O2-dependent metabolic, bactericidal activity and the content of lysosomal cationic proteins, increased spontaneous O2-dependent metabolic activity were revealed. The most pronounced neutrophil functional disorders were detected in patients with chronic obstructive bronchitis (COB). The use of human immunoregulatory recombinant cytokines (interleukin-1 beta, interferon-gamma, tumor necrosis factor alpha) failed to augment in vitro suppressed neutrophil antibacterial (phagocytic) activity in patients with COB. These patient's neutrophil antibacterial activity restored in vitro in the presence of allogeneic (nonactivated or interleukin-2-activated) lymphocytes. The data obtained provide evidence for healthy donor's lymphocytes use in immunocorrection of patients with chronic bronchitis.
Pechkovskiĭ
D V
DV
Vil'kitskaia
N O
NO
Potapnev
M P
MP
D000208:Acute Disease; D001770:Blood Bactericidal Activity / Q000276:immunology*; D001991:Bronchitis / Q000276:immunology* / Q000628:therapy; D002908:Chronic Disease; D016207:Cytokines / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology
D016207:Cytokines
Antibakterial'naia funktsiia neĭtrofilov u bol'nykh khronicheskim bronkhitom. Immunokorrektsiia s pomoshch'iu tsitokinov vospaleniia i allogennykh limfotsitov in vitro.