Effect of endothelin, angiotensin II and ANP on proliferation of vascular smooth muscle cells and cardiomyocytes.
By means of cell culture, 3H-thymidine (3H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG II) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG II.
Wu
J M
JM
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University, PRC.
Cheng
T
T
Sun
S D
SD
Niu
D D
DD
Zhang
J X
JX
Wang
S H
SH
Tang
J
J
Tang
C S
CS
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D016232:Endothelins / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D009206:Myocardium / Q000166:cytology; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
D016232:Endothelins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D004247:DNA