title: Variations in flows and pressures during jet ventilation in the infant: a model study.
abstract: Ventilatory flow rates with either He-O2 (heliox) or N2-O2 (nitrox) mixtures during high frequency jet ventilation (HFJV) were calculated using a mathematical model, and were measured in a physical monoalveolar model of the infant lung. A constant flow was delivered to the model (Vd) drawing with it an entrained flow (Ve). When the inspiratory time (Tl) was long, a back flow (Vr) was generated that increased progressively as the alveolar pressure increased. In order to reduce Vr, the reflux time (Tr), i.e., the time needed for the injected gas to reflux, was measured (Trm) and calculated (Trc) with the model. The Tr depends on both chest-lung compliance and resistance to reflux as well as on the Ve/Vd ratio. For a given setting of the ventilator, values of Trm and Trc were significantly lower with heliox than nitrox (P < 0.01), and the correlation between Trm and Trc were fair with both gases. Tidal volume (VT) was calculated when the Tl was interrupted at Tr. The values of VT were significantly higher with helix than nitrox (P < 0.05). It is concluded that the evaluation of Tr during HFJV may provide useful information for setting the ventilator.
authors.affiliation: Physiology Laboratory, Victor Pachon Faculty, University of Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Belaguid
authors.forename: H
authors.initials: H
authors.lastname: Guenard
mesh_terms: D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D006371:Helium / Q000494:pharmacology*; D006611:High-Frequency Jet Ventilation; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects* / Q000502:physiology*; D008170:Lung Compliance / Q000187:drug effects / Q000502:physiology; D008433:Mathematics; D008962:Models, Theoretical; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology*; D055585:Physical Phenomena; D010825:Physics; D011312:Pressure; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000502:physiology; D012123:Pulmonary Ventilation / Q000187:drug effects / Q000502:physiology; D013990:Tidal Volume / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D006371:Helium; C041364:nitrox; C038949:heliox; D009584:Nitrogen; D010100:Oxygen