Stability of sulfaquinoxaline, sulfadimethoxine, and their N4-acetyl derivatives in chicken tissues during frozen storage.
The N4-acetyl derivatives of sulfaquinoxaline and sulfadimethoxine were stable in fortified chicken liver and thigh muscle tissues during frozen storage for 1 year at -20 and -70 degrees C. In contrast, the parent compounds depleted approximately 35% in liver tissues at -20 degrees C. The transformation of the depleted sulfa drugs to their N4-glucopyranosyl derivatives was negligible, suggesting that products other than glucosides resulted during the storage period.
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U.S. Department of Agriculture, Eastern Regional Research Center, Agricultural Research Service, Philadelphia, PA 19118.
D000818:Animals; D002645:Chickens; D004355:Drug Stability; D005519:Food Preservation; D005615:Freezing; D008460:Meat / Q000032:analysis*; D013412:Sulfadimethoxine / Q000032:analysis / Q000378:metabolism*; D013428:Sulfaquinoxaline / Q000032:analysis / Q000378:metabolism*
D013412:Sulfadimethoxine; D013428:Sulfaquinoxaline