Difference in clinical features and HLA antigens between familial and non-familial vitiligo of non-segmental type.
Of 131 patients with non-segmental vitiligo studied, 29 (22%) had a family history of this disorder. The clinical features and HLA antigens were assessed, and a comparison made between patients with familial and those with non-familial, non-segmental vitiligo. Familial patients developed skin lesions significantly earlier than non-familial patients. There was a significant association between HLA-B46 and familial non-segmental vitiligo, whereas HLA-A31 and CW4 were found in non-familial patients. The differences in clinical features and HLA phenotypes suggest heterogeneity in the pathogenic process between familial and non-familial vitiligo patients.
Ando
I
I
Department of Dermatology, Tokyo University Branch Hospital, Japan.
Chi
H I
HI
Nakagawa
H
H
Otsuka
F
F
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D030342:Genetic Diseases, Inborn / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007223:Infant; D008861:Microsomes / Q000276:immunology; D008875:Middle Aged; D010641:Phenotype; D013954:Thyroglobulin / Q000276:immunology; D014820:Vitiligo / Q000235:genetics / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006680:HLA Antigens; D013954:Thyroglobulin