A field isolate of Sendai virus: its high virulence to mice and genetic divergence form prototype strains.
A field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains.
Sakaguchi
T
T
Department of Bacteriology, Hiroshima University School of Medicine, Japan.
Kiyotani
K
K
Sakaki
M
M
Fujii
Y
Y
Yoshida
T
T
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D014644:Genetic Variation; D008168:Lung / Q000382:microbiology*; D008297:Male; D051379:Mice / Q000382:microbiology*; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010222:Parainfluenza Virus 1, Human / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D018184:Paramyxoviridae Infections / Q000382:microbiology; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics; D014774:Virulence; D014779:Virus Replication
D017931:DNA Primers; D014764:Viral Proteins