title: Anticentriolar autoantibodies in children with central nervous system manifestations of Mycoplasma pneumoniae infection.
abstract: Serum samples from 49 children with acute Mycoplasma pneumoniae infection were screened for the presence of antibodies to mitotic spindle apparatus. None of these serum samples showed such antibodies at a screening dilution of 1:40, though anticentriolar antibodies at titres of 1:320 were observed in two children with acute cerebellar dysfunction. Anticentriolar antibodies may play a part in the pathogenesis of CNS disease associated with M pneumoniae infection.
authors.affiliation: Department of Pathology, University of British Columbia, Vancouver, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Cimolai
authors.forename: D
authors.initials: D
authors.lastname: Mah
authors.forename: E
authors.initials: E
authors.lastname: Roland
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D002493:Central Nervous System Diseases / Q000276:immunology* / Q000382:microbiology*; D002502:Centrioles / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009175:Mycoplasma Infections / Q000276:immunology*; D009177:Mycoplasma pneumoniae / Q000302:isolation & purification*; D008941:Spindle Apparatus / Q000276:immunology
chemical_list: D001323:Autoantibodies