Manganese toxicity: muscarinic receptor binding in the mouse brain.
In the present study we determined the effect of repeated administration of manganese chloride on the binding parameters of [3H]quinuclidinyl benzilate (3H-QNB) in striatum, frontal cortex, and hippocampus of mice. Daily intraperitoneal injections of manganese chloride (5 mg Mn/kg) 5 d/wk during 9 wk did not alter the receptor density (Bmax) and the dissociation constant (Kd) of 3H-QNB in the different brain regions studied. These results suggest that chronic treatment with manganese does not affect the binding characteristics of 3H-QNB to the cholinergic muscarinic receptors in mouse brain.
Villalobos
V
V
Department of Neurobiology, Inbiomed-Fundacite, Maracaibo, Venezuela.
Castro
F
F
Bonilla
E
E
Estévez
J
J
Dávila
J O
JO
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002712:Chlorides / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*; D003342:Corpus Striatum / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005625:Frontal Lobe / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D017895:Manganese Compounds / Q000008:administration & dosage / Q000032:analysis; D020149:Manganese Poisoning; D051379:Mice; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000378:metabolism*; D013054:Spectrophotometry, Atomic
D002712:Chlorides; D017895:Manganese Compounds; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; C025340:manganese chloride