title: Short report: treatment of Helicobacter pylori-associated duodenal ulcer with omeprazole plus antibiotics.
abstract: Omeprazole heals most duodenal ulcers after 4 weeks of treatment but relapse is common. Eradication of Helicobacter pylori is associated with reduced rate of ulcer relapse. This study investigates the effect of omeprazole with antibiotics in H. pylori-associated duodenal ulceration. Forty-three patients with endoscopically proven duodenal ulcer and H. pylori entered this study. Treatment consisted of 20 mg omeprazole daily (four weeks) and seven days (first week) treatment with 400 mg metronidazole t.d.s. and 500 mg tetracycline t.d.s. Four weeks after completing the treatment, 81% (35/43) had a healed duodenal ulcer, and 58% (25/43) had H. pylori eradication. In those who healed, at one year 21 remained H. pylori-negative, 12 had persistent H. pylori infection and 2 had re-infection. The ulcer relapse rate at one year was 26%: of the 9 who relapsed, 6 had persistent infection, 2 were re-infected, and only 1 was H. pylori-negative. This combination therapy of antibiotics with omeprazole successfully eradicates Helicobacter pylori and has a lower ulcer relapse than omeprazole alone.
authors.affiliation: Department of Gastroenterology, Meath/Adelaide Hospitals, Trinity College, Dublin, Ireland.
authors.forename: C J
authors.initials: CJ
authors.lastname: McCarthy
authors.forename: R
authors.initials: R
authors.lastname: Collins
authors.forename: S
authors.initials: S
authors.lastname: Beattie
authors.forename: H
authors.initials: H
authors.lastname: Hamilton
authors.forename: C
authors.initials: C
authors.lastname: O'Morain
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D013752:Tetracycline / Q000008:administration & dosage*
chemical_list: D008795:Metronidazole; D013752:Tetracycline; D009853:Omeprazole