Acute myocardial infarction complicating prothrombin complex concentrate therapy in an 8-year-old boy with hemophilia A and factor VIII inhibitor.
OBJECTIVE
An 8-year-old boy with mild hemophilia A and inhibitors developed an acute myocardial infarction during treatment with prothrombin complex concentrates.


CONCLUSIONS
This rare complication warrants restriction of dosage and length of treatment with these products to the recommended guidelines. It also appears that noninvasive cardiac monitoring of these patients is beneficial.
Karayalcin
G
G
Schneider Children's Hospital of Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042.
Goldberg
B
B
Cherrick
I
I
Kurer
C
C
Bierman
F
F
Lanzkowsky
P
P
D001779:Blood Coagulation Factors / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D005169:Factor VIII; C065655:anti-inhibitor coagulant complex