title: The Western Sydney Stroke Risk in the Elderly Study. A 5-year prospective study.
abstract: Aging of the Australian population, as in other developed nations, will ensure that stroke remains one of the most important causes of death and disability. The Stroke Risk in the Elderly (SITE) study aims to measure prospectively the independent contribution of dietary, sociodemographic, blood lipid, blood pressure, and hemostatic factors to risk of stroke and other cardiovascular outcomes. The target population included all independently living men and women aged 65 years and over, residents in several retirement villages in western metropolitan Sydney, New South Wales, Australia. The study cohort consists of 225 men and 787 women, selected as a convenience sample from all eligible residents in the local government areas (LGAs) adjacent to Westmead Hospital. Participants attended a baseline session to complete dietary, life-style, medical, and sociodemographic questionnaires. Anthropomorphic variables and blood pressure were measured. Blood was taken for measurement of serum lipid, glucose, and hemostatic factors. Questionnaire results were compared with an age/sex-stratified, randomly selected sample drawn from the community (in the same LGAs), in order to quantify potential sampling and selection biases. The study cohort will be followed for a minimum of 5 years. The attendance rate of eligible residents for a baseline medical, dietary, life-style, and sociodemographic assessment was 72% for males and 69% for females. The study cohort was older, better educated, less ethnically diverse, and among women, less likely to have ever been married compared to people aged over 65 years in the comparison group. The baseline results suggest that hemostatic factors may be of importance in assessing risk of cardiovascular disease, (CVD), particularly in older men.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Channing Laboratory, Harvard Medical School, Boston, MA 02115.
authors.forename: M D
authors.initials: MD
authors.lastname: Gliksman
authors.forename: R
authors.initials: R
authors.lastname: Lazarus
authors.forename: A
authors.initials: A
authors.lastname: Wilson
authors.forename: S R
authors.initials: SR
authors.lastname: Leeder
authors.forename: J
authors.initials: J
authors.lastname: Koutts
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D004034:Diet Surveys; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000150:complications; D008019:Life Style; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D015983:Selection Bias; D012959:Socioeconomic Factors