Copper pumping ATPases: common concepts in bacteria and man.
Recently, four genes encoding putative copper pumping ATPases have been cloned from widely different sources: two genes from Enterococcus hirae that are involved in copper metabolism and two human genes that are defective in the copper-related Wilson and Menkes disease. The predicted gene products are P-type ATPases. They exhibit extensive sequence similarity and appear to be members of a new class of ATP driven copper pumps involved in the regulation of cellular copper.
Solioz
M
M
Department of Clinical Pharmacology, University of Berne, Switzerland.
Odermatt
A
A
Krapf
R
R
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology*; D003300:Copper / Q000378:metabolism*; D016983:Enterococcus / Q000201:enzymology / Q000235:genetics; D006527:Hepatolenticular Degeneration / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000201:enzymology / Q000235:genetics; D008969:Molecular Sequence Data; D017510:Protein Folding
D003300:Copper; D000251:Adenosine Triphosphatases