Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo.
Oral administration (250 mg/kg) of menthofuran, a monoterpene furan, to rats once daily for 3 days caused hepatotoxicity as judged by a significant increase in serum glutamate pyruvate transaminase (SGPT) and decreases in glucose-6-phosphatase and aminopyrine N-demethylase activities. Administration of menthofuran also resulted in a decrease in the levels of liver microsomal cytochrome P-450, whereas cytochrome b5 and NAD(P)H-cytochrome c reductase activities were not affected. These effects of menthofuran were both dose- and time-dependent. Pretreatment of rats with phenobarbital (PB) prior to menthofuran treatment potentiated hepatotoxicity suggesting that a PB-induced cytochrome P-450 catalyzed the formation of reactive metabolite(s) responsible for the hepatotoxicity.
Madyastha
K M
KM
Department of Organic Chemistry, Indian Institute of Science, Bangalore.
Raj
C P
CP
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood*; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D039821:Monoterpenes; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013729:Terpenes / Q000008:administration & dosage / Q000633:toxicity*
D039821:Monoterpenes; D013729:Terpenes; C054487:menthofuran; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D000410:Alanine Transaminase; D005952:Glucose-6-Phosphatase; D010634:Phenobarbital