2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice.
Chang
A C
AC
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Takemori
A E
AE
Portoghese
P S
PS
D000081:Acetamides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000345:Affinity Labels; D000818:Animals; D001665:Binding Sites; D006168:Guinea Pigs; D017879:Isothiocyanates / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010147:Pain Measurement; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000081:Acetamides; D000345:Affinity Labels; D017879:Isothiocyanates; D017473:Receptors, Opioid, kappa; C087549:2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide