Compromise in the treatment of hirsutism with flutamide.
The association of Flutamide (500 mg/day) and of a contraceptive pill has been proposed for the treatment of hirsutism but the efficacy of low doses of the antiandrogen as single medication has never been ascertained. Twelve adult hirsute women, aged 31-40 years, were therefore recruited because they were sterile following tubal ligation. Severity of hirsutism was evaluated according to Ferriman and Gallwey scale. After one year, 10 out 12 patients experienced a satisfactory control of their hirsutism with Flutamide dosages varying between 250 and 375 mg/day. The antiandrogen can thus be used at lower dosages than initially expected.
Tremblay
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Hormonal Bioregulation Laboratory, Laval University Hospital Research Center, Ste-Foy, Québec, Canada.
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D005485:Flutamide / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006628:Hirsutism / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013246:Sterilization, Tubal; D013739:Testosterone / Q000097:blood
D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D005485:Flutamide