title: Comparative clinical evaluation of two professional tooth-whitening products.
abstract: A 2-week study was conducted to compare the tooth-whitening efficacy of two 10% carbamide peroxide products: Colgate Platinum Professional Toothwhitening System and Rembrandt Lighten Bleaching Gel. Fifty subjects were divided into two groups and assigned a product to use for 2 weeks. Change in tooth color was measured by reflectance spectroscopy at the initiation of study, at 1 week, and at 2 weeks into the study. Color change was calculated using the color-difference equation established by the Commission International de L'Eclairage. Results showed that Colgate Platinum was 62% more effective at tooth whitening after 1 week and 83% more effective after 2 weeks of treatment vs Rembrandt. At the termination of the study, the mean color difference (deltaE) for Colgate Platinum was 4.29 and 2.34 for Rembrandt. Statistical analysis demonstrated that the Colgate product is significantly superior at increasing tooth whiteness, increasing tooth lightness, reducing redness, and reducing yellowness.  In this study, no adverse reactions were noted on clinical examination and none were reported by panelists with normal healthy dentition.
authors.affiliation: University of California, Los Angeles, School of Dentistry.
authors.forename: G M
authors.initials: GM
authors.lastname: Kowitz
authors.forename: S A
authors.initials: SA
authors.lastname: Nathoo
authors.forename: R
authors.initials: R
authors.lastname: Wong
mesh_terms: D000704:Analysis of Variance; D000077463:Carbamide Peroxide; D003124:Colorimetry; D003188:Composite Resins / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D010545:Peroxides / Q000627:therapeutic use*; D019279:Resin Cements; D016037:Single-Blind Method; D013997:Time Factors; D014073:Tooth Bleaching; D014075:Tooth Discoloration / Q000628:therapy*; D014508:Urea / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D003188:Composite Resins; D004338:Drug Combinations; D010545:Peroxides; D019279:Resin Cements; D000077463:Carbamide Peroxide; C049160:Den-Mat; D014508:Urea