title: Synthesis of some 4-oxo-delta 2-thiazolin-2-ylhydrazones as potential antiprotozoal agents.
abstract: Several 4-oxo-delta 2-thiazolin-2-ylhydrazone derivatives 6 (6-1 - 6-19) derived from the cyclization reaction between the thiosemicarbazones 5 and homologous alpha-chloroacids were prepared. Only compound 6-2 was found to be active against Entamoeba histolytica and Trichomonas vaginalis.
authors.affiliation: Departamento de Farmácia, Universidade Federal de Pernambuco, Recife, PE, Brazil.
authors.forename: A J
authors.initials: AJ
authors.lastname: Alves
authors.forename: A C
authors.initials: AC
authors.lastname: Leite
authors.forename: D P
authors.initials: DP
authors.lastname: De Santana
authors.forename: T M
authors.initials: TM
authors.lastname: Beltrao
authors.forename: M R
authors.initials: MR
authors.lastname: Coelho
authors.forename: P
authors.initials: P
authors.lastname: Gayral
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D006835:Hydrazones; D013844:Thiazoles; D008795:Metronidazole