title: Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD.
abstract: The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role in cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY.
authors.forename: E
authors.initials: E
authors.lastname: Hollander
authors.forename: L J
authors.initials: LJ
authors.lastname: Cohen
authors.forename: C
authors.initials: C
authors.lastname: DeCaria
authors.forename: J B
authors.initials: JB
authors.lastname: Saoud
authors.forename: D J
authors.initials: DJ
authors.lastname: Stein
authors.forename: T B
authors.initials: TB
authors.lastname: Cooper
authors.forename: N N
authors.initials: NN
authors.lastname: Islam
authors.forename: M R
authors.initials: MR
authors.lastname: Liebowitz
authors.forename: D F
authors.initials: DF
authors.lastname: Klein
mesh_terms: D000328:Adult; D005260:Female; D005277:Fenfluramine / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000097:blood*; D010879:Piperazines / Q000097:blood* / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D017366:Serotonin Receptor Agonists / Q000097:blood* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D010879:Piperazines; D017366:Serotonin Receptor Agonists; D005277:Fenfluramine; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone