Metabolites of Pseudevernia furfuracea (L.) Zopf. and their inhibition potential of proteolytic enzymes.
Atranorin (1), physodic acid (2), oxyphysodic acid (3) and virensic (4) acid were identified in P. furfuracea, a lichen species collected in West Tatra. According to HPLC analysis contents of these metabolites in dried material was 0.11-0.19% (1), 1.46-3.78% (2), 1.69 to 3.44% (3), 1.14-1.46% (4). Atranorin was the strongest inhibitor of trypsin as well as of the porcine pancreatic elastase.
Proksa
B
B
Slovak Technical University, Faculty of Chemistry, Department of Biochemical Technology, Bratislava.
Adamcová
J
J
Sturdíková
M
M
Fuska
J
J
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D008011:Lichens / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010179:Pancreas / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013552:Swine; D014361:Trypsin Inhibitors / Q000302:isolation & purification / Q000494:pharmacology
D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D010196:Pancreatic Elastase