title: Antifungal agents. VI. In vitro antifungal activities of halobenzoyl esters of cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3- dioxolan-4-yl]carbinols.
abstract: The synthesis and the in vitro antifungal activities against Candida albicans and Candida spp of a number of halobenzoyl esters of cis- and trans- [2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4- yl]carbinols is reported. Some new imidazoles were found more active than ketoconazole and sometimes as potent as bifonazole against Candida albicans. All derivatives were found scarcely active against Candida spp.
authors.affiliation: Dipartamento di Scienze Farmaceutiche, Università di Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Stefancich
authors.forename: R
authors.initials: R
authors.lastname: Silvestri
authors.forename: E
authors.initials: E
authors.lastname: Pagnozzi
authors.forename: M
authors.initials: M
authors.lastname: Artico
authors.forename: A
authors.initials: A
authors.lastname: Retico
authors.forename: G
authors.initials: G
authors.lastname: Apuzzo
authors.forename: N
authors.initials: N
authors.lastname: Simonetti
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
chemical_list: D000935:Antifungal Agents; D001713:Biphenyl Compounds; D004148:Dioxolanes; D007093:Imidazoles; C036596:bifonazole; D007654:Ketoconazole