Peculiar membranogranular glomerular deposits.
Two patients with immune complex diseases, one with IgA nephropathy and the other with systemic lupus erythematosus, were found to have peculiar membranogranular deposits in the glomeruli in addition to typical immune complex deposits. There was no clinical indication of familial lipodosis in either case. The deposits were very similar to those seen in lecithin-cholesterol acyltransferase-deficient patients. The pathogenetic role of lipid deposits in the glomerulus is discussed.
Min
K W
KW
Department of Pathology, Oklahoma Health Science Center, Oklahoma City 73190.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000378:metabolism*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*
D000936:Antigen-Antibody Complex