Molecular biology of breast carcinoma.
During the last several years basic research has resulted in the identification of many of the factors involved in signal transduction pathways, leading us to a greater understanding of the mechanisms of growth control in breast cancer cells. Many of these factors are the products of proto-oncogenes or suppressor genes. This review describes the role of some of these factors in breast cancer development, progression, and metastasis and discusses implications for future directions.
el-Ashry
D
D
Department of Biochemistry and Molecular Biology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C. 20007.
Lippman
M E
ME
D001943:Breast Neoplasms / Q000235:genetics*; D002455:Cell Division; D005260:Female; D006801:Humans; D011379:Prognosis; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics; D011987:Receptors, Steroid / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics*
D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D011987:Receptors, Steroid; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)