Molecular genetics of human thyroid neoplasms.
Cancers are thought to develop as a result of sequential mutations of genes important in the control of cellular growth. Recently investigators identified a number of genetic defects that affect oncogenes and tumor-suppressor genes and that provide insight into the biology of benign and malignant thyroid neoplasms. Future implications for thyroid tumor diagnosis and prognosis are considered in this chapter.
Fagin
J A
JA
Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California 90048.
D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D008297:Male; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics; D009857:Oncogenes / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm