Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.
We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec-1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec-1/mg, p = 0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.
Parker
W D
WD
Department of Neurology, University of Colorado School of Medicine, Denver.
Mahr
N J
NJ
Filley
C M
CM
Parks
J K
JK
Hughes
D
D
Young
D A
DA
Cullum
C M
CM
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology*; D001792:Blood Platelets / Q000201:enzymology*; D003576:Electron Transport Complex IV / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000201:enzymology
D003576:Electron Transport Complex IV