Reduction in the level of immobilization in forced swim test and ethanol intake in rats by oxygen therapy.
Experiments replicated the previous finding that rats with high immobilization time in the forced swim test (passive rats) consumed more 15% ethanol solution in a free choice situation with tap water than rats with active behavior (active rats). Exposure of passive rats to oxygen under normal and elevated (2 ata) pressure resulted in the decrease in immobilization scores in the forced swim test as well as reduction in alcohol consumption and preference.
Kampov-Polevoy
A B
AB
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Dubtchenko
V V
VV
Crosby
R D
RD
Halikas
J A
JA
D000428:Alcohol Drinking; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D006931:Hyperbaric Oxygenation; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000517:prevention & control*; D010100:Oxygen / Q000627:therapeutic use*; D051381:Rats; D013550:Swimming
D000431:Ethanol; D010100:Oxygen