[The use of a complex cobalt compound as a cyanide antidote].
The medical effect of the cobalt (III) complex compound [Co(DH)2(H2O)2]Cl poisoning by potassium cyanide has been experimentally found. The poisoning has been caused by intravenous potassium cyanide, 1 mg/kg. The aqueous solution of the complex was added the same to cyanide in doses of 40 and 80 mg/kg. The poison and antidote effects were controlled by bioelectrical tests of the brain and heart. The advantage of the preparation is its direct interaction with cyanide and significantly lower doses as compared with the well-known anticyanide antidotes.
Bovykin
B A
BA
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use* / Q000633:toxicity; D002415:Cats; D003035:Cobalt / Q000627:therapeutic use* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011041:Poisoning / Q000188:drug therapy / Q000503:physiopathology; D011190:Potassium Cyanide / Q000506:poisoning*; D012996:Solutions
D000931:Antidotes; D012996:Solutions; D003035:Cobalt; D011190:Potassium Cyanide
Primenenie kompleksnogo soedineniia kobal'ta v kachestve protivotsianidnogo antidota.