Investigations on plasma levels of mast cell mediators in acute atopic dermatitis.
Skin mast cells have been proposed to be involved in the pathogenesis of acute and chronic phases of atopic dermatitis (AD). The aim of the present study was to investigate the significance of different mast cell mediators during acute exacerbation of this frequent skin disease. Plasma levels from 19 patients with AD were screened for elevation of the mast cell-specific protease tryptase, the biogene amine histamine, and the arachidonic acid metabolite prostaglandin D2. None of the patients showed elevated plasma levels of these three mediators, whereas the mean serum IgE level was strongly elevated. We conclude that the investigated mediators are either only active on the cutaneous level or that other mediators are responsible for the development of the acute eczematous and pruritic skin reactions. Alternatively, the assays could have been insufficiently sensitive since some studies have demonstrated increased plasma histamine levels, e.g. after food challenge of such patients.
Amon
U
U
Department of Dermatology, Medical University of Lübeck, Germany.
Menz
U
U
Wolff
H H
HH
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D053818:Chymases; D003876:Dermatitis, Atopic / Q000097:blood*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D009994:Osmolar Concentration; D015230:Prostaglandin D2 / Q000097:blood; D012016:Reference Values; D012697:Serine Endopeptidases / Q000097:blood; D053802:Tryptases
D007073:Immunoglobulin E; D006632:Histamine; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; D015230:Prostaglandin D2