title: [Levamisole in children with frequently recurring idiopathic nephrotic syndrome].
abstract: 10 children (8 boys and 2 girls) with frequently relapsing idiopathic nephrotic syndrome were treated with levamisole (5 mg/kg weekly). In 6 children with steroid dependent nephrotic syndrome a marked reduction in steroids by 62% to 75% was possible. Severe, transient neutropenia was observed in one patient. Levamisole failed to influence the disease course positively in 3 patients with relapses associated with intercurrent illness. It is concluded that levamisole may favourably influence steroid dependence in children with frequently relapsing idiopathic nephrotic syndrome.
authors.affiliation: Abteilung für Nephrologie, Medizinischen Universitäts-Kinderklinik Bern.
authors.forename: P
authors.initials: P
authors.lastname: Meregalli
authors.forename: M G
authors.initials: MG
authors.lastname: Bianchetti
authors.forename: G
authors.initials: G
authors.lastname: Imoberdorf
authors.forename: J
authors.initials: J
authors.lastname: Lütschg
authors.forename: D
authors.initials: D
authors.lastname: Reymond
authors.forename: O H
authors.initials: OH
authors.lastname: Oetliker
mesh_terms: D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D007978:Levamisole; D003520:Cyclophosphamide
vernacular_title: Levamisol bei Kindern mit häufig rezidivierendem idiopathischem nephrotischem Syndrom.