[Improvement of prostacyclin-thromboxane A2 balance in patients with acute myocardial infarction by intermittent aspirin].
Forty two patients with acute myocardial infarction (AMI) were randomly distributed to the following groups: (1) the non-aspirin-treated group; (2) the daily-aspirin-treated group (aspirin, 300mg, once everyday); (3) the intermittent-aspirin-treated group (aspirin, 300mg, once every three days). In addition to the three groups, a group of normal subjects was selected. Blood was taken by venipuncture of the antecubital vein in patients on the first, second, seventh, fourteenth and twenty-first hospitalized days. The plasma levels of 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha) and thromboxane B2(TXB2) were measured respectively by the scintillation counting of radioimmunoassay. The ratio of 6-keto-PGF1 alpha to TXB2 (K/T ratio) was also calculated. Conclusions were as follows: (1) Intermittent treatment with low-dose aspirin is superior to daily treatment in improving the PGI2/TXA2 balance in patients with AMI. (2) Daily low-dose aspirin has cumulative inhibitory effects on PGI2 and TXA2 synthesis in AMI patients. While intermittent treatment has the same cumulative inhibitory effect on TXA2 synthesis as daily treatment, but no cumulative inhibitory effect on PGI2 synthesis.
Luo
Y
Y
Guangzhou First Municipal People's Hospital.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D001241:Aspirin