title: Expression of HLA-class II antigen in gastric carcinomas. Its relationship to histopathological grade, lymphocyte infiltration and five-year survival rate.
abstract: To investigate whether the expression of HLA-DR antigen in gastric carcinomas is associated with the survival rate, we studied 70 cases of gastric carcinoma using a monoclonal antibody. Forty-seven cases (67%) stained positively, including 31 differentiated carcinomas, and 16 undifferentiated carcinomas. A close correlation was found between expression of HLA-DR antigen and differentiation of the tumor cells. Marked lymphocyte infiltration was seen in the HLA-DR antigen positive cancers. In advanced gastric cancers, the 5-year survival rate of patients with HLA-DR antigen positive cancers was significantly higher (67.5%) than that of patients with HLA-DR antigen negative cancers (40%). The data suggest that the expression of HLA-DR antigen in gastric carcinomas may reflect the degree of tumor cell differentiation, and influence the host immune response and prognosis.
authors.affiliation: Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
authors.forename: X C
authors.initials: XC
authors.lastname: Ma
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: R
authors.initials: R
authors.lastname: Kushima
authors.forename: N
authors.initials: N
authors.lastname: Terata
authors.forename: M
authors.initials: M
authors.lastname: Kodama
mesh_terms: D002277:Carcinoma / Q000276:immunology*; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D006684:HLA-DR Antigens