title: Dramatic increase in levels of placental protein 14 in amniotic fluid at 10-15 weeks' pregnancy.
abstract: Concentrations of placental protein 14 (PP14) were measured by radioimmunoassay in 103 amniotic fluid samples from 10 to 20 weeks of pregnancy. Low levels of PP14 were present at 10-12 weeks (median values 82-280 micrograms/l). After 12 weeks, the levels increased by two orders of magnitude to reach a peak at 18 weeks (median 11 mg/l). This pattern may reflect the obliteration of the extraembryonic coelom and direct apposition of the decidua with the chorio-amnion.
authors.affiliation: Department of Obstetrics, Gynaecology and Reproductive Physiology, St. Bartholomew's Hospital Medical College, West Smithfield, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Chatzakis
authors.forename: N
authors.initials: N
authors.lastname: Wathen
authors.forename: J
authors.initials: J
authors.lastname: Campbell
authors.forename: R
authors.initials: R
authors.lastname: Iles
authors.forename: A
authors.initials: A
authors.lastname: Dawnay
authors.forename: T
authors.initials: T
authors.lastname: Chard
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D013997:Time Factors
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins