Structures of mefenamic acid metabolites from human urine.
Three major metabolites of mefenamic acid were isolated from the urine of a normal adult man receiving mefenamic acid orally. The structures of those metabolites were determined as glucuronides of mefenamic acid, its hydroxymethyl derivative, and its carboxylic acid derivative on the basis of spectral data.
Sato
J
J
Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.
Yamane
Y
Y
Ito
K
K
Bando
H
H
D000328:Adult; D001711:Biotransformation; D005965:Glucuronates / Q000652:urine; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008528:Mefenamic Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000652:urine*
C084196:1-O-(2-(3-hydroxymethyl-2-methylphenyl)aminobenzoyl)glucopyranuronic acid; D005965:Glucuronates; C084198:1-O-(2-(2,3-dimethylphenyl)aminobenzoyl)glucopyranuronic acid; C084197:1-O-(2-(3-carboxy-2-methylphenyl)aminobenzoyl)glucopyranuronic acid; D008528:Mefenamic Acid