1,2,3-Triazole[4,5-d]pyridazines--I. Analogues of prostaglandin synthesis inhibitors.
This paper reports the preparation of new triazolepyridazine derivatives bearing in the 1 position an acidic substituent, on the basis of a working hypothesis relating these compounds to 1,2,3-triazole derivatives, effective in vitro inhibitors of the prostaglandin synthesis. The tested compounds were lacking of biological activity.
Biagi
G
G
Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Pisa.
Ferretti
M
M
Giorgi
I
I
Livi
O
O
Scartoni
V
V
Lucacchini
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000097:blood; D011448:Prostaglandin Antagonists; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011448:Prostaglandin Antagonists; D011724:Pyridazines; D014230:Triazoles; D008315:Malondialdehyde