title: Hyperperfusion and early technetium-99m-HMPAO SPECT appearance of central nervous system toxoplasmosis.
abstract: Three correlative 99mTc-HMPAO brain SPECT studies were performed on an AIDS patient from the early stage of a CNS toxoplasma lesion to its resolution after specific therapy. A hyperactive area in the right parieto-occipital lobe appeared in the first SPECT study, matching the heterogeneous T2-weighted image with Gd-DTPA enhancement reported on MRI. Both studies were performed 3 days after the onset of neurological symptoms when no abnormalities were found on a CT scan. This fact can be explained by the hyperemia that occurs in the acute stage of inflammation. Three months later, along with clinical improvement under specific treatment, both MRI and brain SPECT were normal. No hypoperfusion was seen in SPECT images, probably because the necrotic phase of the toxoplasma lesion was not reached in this case.
authors.affiliation: Department of Nuclear Medicine, Hospital Clinic i Provincial, University of Barcelona, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Catafau
authors.forename: M
authors.initials: M
authors.lastname: Solá
authors.forename: F J
authors.initials: FJ
authors.lastname: Lomeña
authors.forename: A
authors.initials: A
authors.lastname: Guelar
authors.forename: J M
authors.initials: JM
authors.lastname: Miró
authors.forename: J
authors.initials: J
authors.lastname: Setoain
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D016781:Toxoplasmosis, Cerebral / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime