Tolerability of combined treatment with lithium and fluoxetine: 14 cases treated under open conditions.
Fourteen cases of depression resistant to multiple treatments were treated by lithium augmentation of fluoxetine. Tolerability of the treatment was poor. Lithium and fluoxetine may be a possible treatment for resistant depression but there is caution regarding tolerability and toxicity with the relatively high doses of lithium used in this series.
Hawley
C J
CJ
Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK.
Roberts
A G
AG
Baldwin
D S
DS
D000328:Adult; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D005473:Fluoxetine; D016651:Lithium Carbonate