title: Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests.
abstract: This paper presents a 7 year old girl with cough variant asthma, in which house dust challenge test provoked fine crackles on auscultation without any changes of lung function test. Pretreatment with DL-chlorpheniramine maleate for 7 days inhibited the appearance of fine crackles. On histamine inhalation test, fine crackles and rhonchi appeared on auscultation without bronchoconstriction (% fall of one-second forced expiratory volume < 10%). These data suggest that the cause of cough variant asthma is mainly an immunoglobulin E-mediated allergic reaction in the mucus secreting system.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Morikawa
authors.forename: M
authors.initials: M
authors.lastname: Mitsuhashi
authors.forename: H
authors.initials: H
authors.lastname: Tabata
authors.forename: Y
authors.initials: Y
authors.lastname: Seki
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: K
authors.initials: K
authors.lastname: Tokuyama
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
mesh_terms: D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002648:Child; D003371:Cough / Q000503:physiopathology*; D004391:Dust; D005260:Female; D006632:Histamine; D006801:Humans; D016210:Methacholine Chloride
chemical_list: D004391:Dust; D016210:Methacholine Chloride; D006632:Histamine