title: Serious childhood angiomas: unsuccessful alpha-2b interferon treatment. A report of four cases.
abstract: Over a 4-year period, we managed four children with alarming haemangiomas (two cases of Kasabach-Merritt syndrome and two life-threatening haemangiomas). Systemic steroid therapy was ineffective. Other treatments (radiotherapy, anti-platelet drugs) were also ineffective in the Kasabach-Merritt patients. On the basis of recent reports on the effects of interferon on endothelial cells, we used alpha-2 interferon therapy, but obtained no response.
authors.affiliation: Service de Dermatologie, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Teillac-Hamel
authors.forename: Y
authors.initials: Y
authors.lastname: De Prost
authors.forename: C
authors.initials: C
authors.lastname: Bodemer
authors.forename: P
authors.initials: P
authors.lastname: Andry
authors.forename: O
authors.initials: O
authors.lastname: Enjolras
authors.forename: G
authors.initials: G
authors.lastname: Sebag
authors.forename: F
authors.initials: F
authors.lastname: Brunelle
authors.forename: P
authors.initials: P
authors.lastname: Hubert
authors.forename: C
authors.initials: C
authors.lastname: Nihoul-Fekete
mesh_terms: D001132:Arm; D002081:Buttocks; D002675:Child, Preschool; D005145:Face; D005260:Female; D006391:Hemangioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D017211:Treatment Failure
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins