title: Pharmacological screening of plants recommended by folk medicine as snake venom antidotes; IV. Protection against jararaca venom by isolated constituents.
abstract: Fifteen compounds, isolated from plants reputed as snake venom antidotes, belonging to different classes of natural products, were shown to protect mice to a significant degree against the lethal action of the venom of Bothrops jararaca snakes. Administration was by the oral route, one hour prior to envenomation. The substances are nitrogen-free, low-molecular-weight compounds for which some kind of biodynamic activity has previously been reported. The fact that they are mostly trivial, naturally-occurring compounds should explain why plants used as snake-bite antidotes are so widely distributed over the plant kingdom.
authors.affiliation: Departamento de Farmacologia, CCS-ICB, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: N A
authors.initials: NA
authors.lastname: Pereira
authors.forename: B M
authors.initials: BM
authors.lastname: Pereira
authors.forename: M C
authors.initials: MC
authors.lastname: do Nascimento
authors.forename: J P
authors.initials: JP
authors.lastname: Parente
authors.forename: W B
authors.initials: WB
authors.lastname: Mors
mesh_terms: D000818:Animals; D000931:Antidotes; D017837:Bothrops; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors*; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
chemical_list: D000931:Antidotes; D003435:Crotalid Venoms; D010936:Plant Extracts