title: An outbreak of Pneumocystis carinii pneumonia in children with malignancy.
abstract: An outbreak of Pneumocystis carinii pneumonia (PCP) in three patients within a 6 week period was reported. Two patients had acute lymphoblastic leukaemia and one had brain-stem glioma. They shared common features of immunosuppression and absence of cotrimoxazole prophylaxis and had been nursed in the same room. The severity of PCP and its response to treatment may be related to the degree of immunosuppression. Because of the morbidity and mortality of PCP, chemoprophylaxis should be given to all at-risk cases. Furthermore, isolation of patients with PCP should be considered in view of increasing evidence of nosocomial transmission.
authors.affiliation: University Paediatric Unit, Queen Mary Hospital, University of Hong Kong.
authors.forename: Y F
authors.initials: YF
authors.lastname: Cheung
authors.forename: C F
authors.initials: CF
authors.lastname: Chan
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: Y L
authors.initials: YL
authors.lastname: Lau
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D004196:Disease Outbreaks; D004359:Drug Therapy, Combination; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy