title: 1H magnetic resonance spectroscopy in the investigation of intractable epilepsy.
abstract: We have been using proton magnetic resonance spectroscopy (1H MRS) in the investigation of adults and children with intractable epilepsy. Spectra were obtained from 2 x 2 x 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N-acetylaspartate (NAA), creatine+phosphocreatine (Cr), and choline-containing compounds (Cho). In comparison with control subjects, the epilepsy patients as a group show significant reductions in the NAA signal and in the NAA/Cho+Cr ratio, with increases in the Cho and Cr signals. The reduction in NAA is interpreted in terms of neuronal loss or damage, while the increase in Cr and Cho signals may be a reflection of reactive astrocytosis.
authors.affiliation: Radiology and Physics Unit, Institute of Child Health, London, England.
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: A
authors.initials: A
authors.lastname: Connelly
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
authors.forename: J H
authors.initials: JH
authors.lastname: Cross
authors.forename: F J
authors.initials: FJ
authors.lastname: Kirkham
authors.forename: C L
authors.initials: CL
authors.lastname: Johnson
authors.forename: F
authors.initials: F
authors.lastname: Vargha-Khadem
authors.forename: B G
authors.initials: BG
authors.lastname: Nevile
authors.forename: G D
authors.initials: GD
authors.lastname: Jackson
mesh_terms: D000328:Adult; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D013702:Temporal Lobe / Q000378:metabolism* / Q000473:pathology
chemical_list: D011522:Protons