title: Oculomotor abnormalities and MRI findings in idiopathic cerebellar ataxia.
abstract: Extensive oculomotor testing and quantitative MRI evaluation was performed in seven patients with idiopathic cerebellar ataxia without extracerebellar symptoms (IDCA-C) and in ten patients with additional extracerebellar symptoms (IDCA-P). The most severe oculomotor deficits were disturbed smooth pursuit, optokinetic nystagmus and suppression of the vestibulo-ocular reflex (VOR). The symptoms correlated well and consistently with the amount of atrophy of the flocculus and the dorsal vermis. These correlations, however, were not specific, and deficits also correlated with the amount of atrophy of other cerebellar structures. No correlation was found between saccade velocity and brainstem atrophy or between saccade metrics and atrophy of the dorsal vermis. Although patients with IDCA-P had more severe oculomotor deficits than patients with IDCA-C, the pattern of the oculomotor disturbances was the same for both groups. Thus, eye movement analysis alone is not sufficient to distinguish between patients with pure cerebellar ataxia and those with additional extracerebellar symptoms.
authors.affiliation: Abteilung für Neurologie, Eberhard-Karl-Universität, Tübingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Fetter
authors.forename: T
authors.initials: T
authors.lastname: Klockgether
authors.forename: J B
authors.initials: JB
authors.lastname: Schulz
authors.forename: J
authors.initials: J
authors.lastname: Faiss
authors.forename: E
authors.initials: E
authors.lastname: Koenig
authors.forename: J
authors.initials: J
authors.lastname: Dichgans
mesh_terms: D000328:Adult; D001284:Atrophy; D002524:Cerebellar Ataxia / Q000175:diagnosis* / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000503:physiopathology; D012016:Reference Values; D012154:Reticular Formation / Q000473:pathology; D012438:Saccades / Q000502:physiology