title: Comparison of cartridge insulin Penmix 50:50/Isophane with soluble/Isophane in type I diabetic adolescents using a multiple injection regimen.
abstract: This study investigated the effect on blood sugar control and weight gain of a multiple injection therapy (MIT) regimen in 22 established adolescent diabetics using a pre-prandial 50:50 mixture of Isophane/soluble insulin with night-time Isophane. This regimen was compared in a cross-over study with MIT using pre-prandial soluble insulin and night-time Isophane. After 4 wk for stabilization, there were 2 periods of 16 wk on each regimen. Throughout the study, blood sugar control was monitored by regular HbA1 and fructosamine measurements. The total daily dose of insulin was unchanged throughout the study, 1.0 +/- 0.3 iu/kg/day for Penmix/Isophane and 1.1 +/- 0.3 iu/kg/day for soluble/Isophane. The mean HbA1 and fructosamine did not alter significantly on either regimen. There was no significant weight gain during the Penmix therapy, despite the increased proportion of longer-acting despite the increased proportion of longer-acting insulin. Lean body mass (LBM) measured by skinfold thickness and electrical impedance only changed marginally on either regimen; the correlation between the 2 measuring techniques for LBM was good. Patient acceptance of the 50:50 Penmix insulin was high, 13 of 19 children preferring it to the conventional regimen.
authors.affiliation: Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
authors.forename: K A
authors.initials: KA
authors.lastname: Wheeler
authors.forename: M L
authors.initials: ML
authors.lastname: Ahmed
authors.forename: J A
authors.initials: JA
authors.lastname: Edge
authors.forename: D B
authors.initials: DB
authors.lastname: Dunger
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D007336:Insulin, Isophane / Q000008:administration & dosage* / Q000627:therapeutic use; D061389:Insulin, Regular, Pork; D008297:Male; D012727:Sex Characteristics; D012885:Skinfold Thickness; D015430:Weight Gain / Q000187:drug effects
chemical_list: D007328:Insulin; D061389:Insulin, Regular, Pork; D007336:Insulin, Isophane; C000006:insulin, neutral