title: [The relationship between the magnitude of the negative inotropic action and chemical structure of crown-ether derivatives].
abstract: The relationship between the inotropic effect and chemical structure of 15-crown-5 and 18-crown-6 derivatives was studied in experiments in open-chest anaesthesized cats, by using computer-aided analysis. The findings showed that the 15-crown-5 derivatives produced more pronounced cardiotropic effect and they were less toxic than 18-crown-6 derivatives. Computer-aided analysis revealed pharmacophoric groups which are responsible for cardiotropic (negative inotropic) activity in the series of crown ether derivatives.
authors.forename: K G
authors.initials: KG
authors.lastname: Gurbanov
authors.forename: A A
authors.initials: AA
authors.lastname: Paperno
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: P M
authors.initials: PM
authors.lastname: Vasil'ev
authors.forename: A G
authors.initials: AG
authors.lastname: Breslaukhov
authors.forename: N G
authors.initials: NG
authors.lastname: Luk'ianenko
authors.forename: S S
authors.initials: SS
authors.lastname: Basok
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Kulygina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Bogashchenko
mesh_terms: D000818:Animals; D002415:Cats; D043844:Crown Ethers; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D043844:Crown Ethers; D004988:Ethers, Cyclic; C042148:15-crown-5; C015762:18-crown-6
vernacular_title: Zavisimost' mezhdu velichinoĭ otritsatel'nogo inotropnogo deĭstviia i khimicheskoĭ strukturoĭ proizvodnykh kraun-éfirov.