[The circadian rhythms of the level of ACTH, cortisol and 17-hydroxycorticosteroids in bronchial asthma patients].
The circadian rhythm of hydrocortisone and ACTH in plasma and 17-OCS in the urine were registered in 10 patients with bronchial asthma and 5 healthy subjects. It was found that maximal concentrations of hydrocortisone occurred in the day time whereas those of ACTH at nights in moderate asthma. In its severe forms neither hydrocortisone nor ACTH followed circadian rhythms. It is recommended to treat patients with severe bronchial asthma on the individual basis selecting glucocorticosteroid doses with reference to plasma fluctuations of hydrocortisone.
Landyshev
Iu S
IuS
Mishuk
V P
VP
D015065:17-Hydroxycorticosteroids / Q000652:urine*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001249:Asthma / Q000378:metabolism*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D015065:17-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Sutochnye ritmy urovnia AKTG, kortizola i 17-oksikortikosteroidov u bol'nykh bronkhial'noĭ astmoĭ.