title: Effect of topical 0.5% timolol on tear flow in patients with primary open-angle glaucoma as assessed by fluorophotometry.
abstract: The question as to whether or not topical medication with beta blockers causes a decrease in tear production remains unanswered. Earlier studies using filter-paper strip tests have yielded contradictory results. In the present study, computerized objective fluorophotometry was used to assess the effect of topical medication with 0.5% timolol (b.i.d.; OU) on tear volume and tear production in 24 consecutive patients with bilateral primary open-angle glaucoma. Tear-film fluorophotometry was performed before treatment as well as at 7 days, 14 days, and 4-7 months after the onset of treatment. The results showed that by 7 days after the initiation of timolol treatment, both tear volume (-29%, P < 0.01) and tear secretion (-36%, P < 0.01) had decreased significantly. However, at both 14 days and 4-7 months after the onset of treatment, none of the values differed significantly from those obtained before treatment. Thus, topical antiglaucomatous treatment with 0.5% timolol eye drops leads to a transient decrease in tear production. This effect, however, lasts no longer than 14 days after the beginning of treatment.
authors.affiliation: Universitäts-Augenklinik, Bonn, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Göbbels
authors.forename: T
authors.initials: T
authors.lastname: Mönks
authors.forename: M
authors.initials: M
authors.lastname: Spitznas
mesh_terms: D000287:Administration, Topical; D015590:Fluorophotometry; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009883:Ophthalmic Solutions; D013666:Tears / Q000378:metabolism*; D013999:Timolol / Q000008:administration & dosage*
chemical_list: D009883:Ophthalmic Solutions; D013999:Timolol