title: High dosages of gonadotropins are associated with poor pregnancy outcomes after in vitro fertilization-embryo transfer.
abstract: OBJECTIVE
  To compare the pregnancy outcomes during IVF-ET when different dosages of hMG are used after follicular phase suppression with leuprolide acetate (LA).
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Hospital-based IVF-ET program.
  
  
  METHODS
  From January 1990 to December 1992, 264 cycles reached ET after LA downregulation and gonadotropin stimulation.
  
  
  RESULTS
  Higher doses of gonadotropins, as measured by both average daily dose and total dose per cycle, were associated with lower clinical pregnancy rates. This effect was independent of age, basal FSH level, endometrial thickness, maximal E2 levels, number of eggs retrieved, and embryos transferred.
  
  
  CONCLUSIONS
  High dosages of exogenous gonadotropins are associated with lower pregnancy rates in IVF-ET.
authors.affiliation: Department of Obstetrics and Gynecology, Columbia-Presbyterian Medical Center, New York, New York 10032.
authors.forename: L
authors.initials: L
authors.lastname: Stadtmauer
authors.forename: E C
authors.initials: EC
authors.lastname: Ditkoff
authors.forename: D
authors.initials: D
authors.lastname: Session
authors.forename: A
authors.initials: A
authors.lastname: Kelly
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000188:drug therapy; D008596:Menotropins / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D006062:Gonadotropins; D004958:Estradiol; D008596:Menotropins; D005640:Follicle Stimulating Hormone