title: [Multicenter comparative study of the effects of benazepril and captopril in mild and moderate systemic hypertension].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of benazepril versus captopril in patients with mild or moderate systemic arterial hypertension (SAH).
  
  
  METHODS
  A multicenter, double-blind, randomized trial analyzed 174 patients, mean age of 52 +/- 9 years, 68 (39%) men. After 2 weeks under placebo, 90 patients were treated, during 6 weeks, with 10 mg, once a day, of benazepril (BZ) and 50 mg, twice a day, of captopril (CPT). At week 3, 25 mg of hydrochlorothiazide (HCT) was added if diastolic blood pressure (DBP) was greater than 90 mmHg. Side effects were analyzed as a not related, unlikely, possible, probable and definitive regard to treatment.
  
  
  RESULTS
  Systolic (p < 0.001) and DBP (p < 0.0001) reductions were observed in both groups. Additional reduction was observed in both groups when 25 mg of HCT was added in patients with DBP > 90 mmHg at week 3. Heart rate was unchanged. The response to treatment was better at BZ group (74% versus 59% of good and excellent response; p = 0.037). Side effects classified as probable or definitive in relation to the treatment occur in 3 (3%) and 10 (11%), respectively at BZ an CPT groups. Laboratorial changes were not observed during treatment.
  
  
  CONCLUSIONS
  BZ (10 mg) was superior to CPT (50 mg) in patients with discrete and moderate SAH.
authors.affiliation: Instituto do Coração do Hospital das Clínicas, FMUSP.
authors.forename: J A
authors.initials: JA
authors.lastname: Ramires
authors.forename: A de P
authors.initials: Ade P
authors.lastname: Mansur
authors.forename: F A
authors.initials: FA
authors.lastname: Almeida
authors.forename: J G
authors.initials: JG
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D000368:Aged; D001552:Benzazepines / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D001552:Benzazepines; D002216:Captopril; C044946:benazepril
vernacular_title: Estudo multicêntrico comparativo entre efeitos do benazepril e captopril na hipertensão arterial sistêmica leve e moderada.