Alcoholic cardiomyopathy.
Chronic alcoholism is one of the most important causes of dilated cardiomyopathy, and a large proportion of chronic alcoholics demonstrate impairment of cardiac function. The development of cardiac dysfunction is apparently related to the total lifetime dose of ethanol. Studies in experimental animals have demonstrated that both acute and chronic ethanol administration impair cardiac contractility. However, the relationship, if any, between the acute effects of alcohol and the development of irreversible cardiomyopathy remain to be elucidated.
Rubin
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Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania.
Urbano-Marquez
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A
D000428:Alcohol Drinking / Q000009:adverse effects* / Q000473:pathology; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000473:pathology / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000473:pathology