Topical treatment of experimental acute corneal inflammation by dexamethasone and nonsteroidal drugs.
In this study, we have correlated the relative effectiveness of nonsteroidal anti-inflammatory drugs versus corticosteroids in the topical treatment of acute corneal inflammation. The authors have studied the effect of 1 drop every 6 h of flurbiprofen 0.03%, indomethacin 1%, diclofenac 0.1% and dexamethasone 0.1% in an experimental model of corneal alkali burn. The objective parameters used to evaluate the corneal inflammatory response were Luminol-enhanced chemiluminescence, ultrasonic pachymetry and computer-assisted analysis of the area of the corneal ulceration. Indomethacin 1% showed statistically significant effects on the improvement of all the parameters tested in the study. No such effect was demonstrated for flurbiprofen 0.03% or diclofenac 0.1%. We can conclude that indomethacin 1% is an effective drug in the treatment of experimental acute corneal alkali-burn inflammation.
Alio
J L
JL
Laboratory of Ocular Inflammation, University of Alicante, Medical School, San Vicente del Raspeig, Spain.
Ayala
M J
MJ
Mulet
M E
ME
Artola
A
A
Ruiz
J M
JM
D000208:Acute Disease; D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D003320:Corneal Ulcer / Q000188:drug therapy; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D004195:Disease Models, Animal; D007634:Keratitis / Q000139:chemically induced / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D011817:Rabbits; D012972:Sodium Hydroxide
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D012972:Sodium Hydroxide; D003907:Dexamethasone