Morphologic effects of a sulfur(IV) aerosol on the nasal cavity of beagle dogs.
Morphologic changes were observed in nasal cavities of beagle dogs after long-term exposure to a respirable sulfur(IV) aerosol at a concentration equivalent to a sulfur dioxide (SO2) concentration of 0.6 mg/m3. The changes were characterized by a thickened epithelial layer resulting from epithelial proliferation, by a loss of secretory material, and by moderate mononuclear cell infiltration.
Takenaka
S
S
GSF-Forschungszentrum für Umwelt und Gesundheit Neuherberg, Projekt Inhalation, Oberschleissheim, Germany.
Fürst
G
G
Heilmann
P
P
Heini
A
A
Heinzmann
U
U
Karg
E
E
Murray
A B
AB
Ruprecht
L
L
Heyder
J
J
D000280:Administration, Inhalation; D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D004285:Dogs; D008297:Male; D009296:Nasal Cavity / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*; D010084:Oxidation-Reduction; D013455:Sulfur / Q000737:chemistry / Q000633:toxicity*; D013458:Sulfur Dioxide / Q000737:chemistry / Q000633:toxicity; D013461:Sulfur Oxides / Q000737:chemistry / Q000633:toxicity; D013997:Time Factors
D000336:Aerosols; D000393:Air Pollutants; D013461:Sulfur Oxides; D013458:Sulfur Dioxide; D013455:Sulfur