title: Influence of long-term erythropoietin treatment on plasma levels of calcium-phosphate related hormones in haemodialyzed uraemic patients.
abstract: Exacerbation of secondary hyperparathyroidism (as manifested by calcium deposits and local inflammation in periarticular tissues) has been reported in haemodialyzed (HD) uraemic patients treated with recombinant human erythropoietin. However, short-term treatment with recombinant human erythropoietin (r-Hu EPO) did not influence significantly plasma levels of parathyroid hormone (PTH), calcitonin (CT) and 25-hydroxycholecalciferol (25-OHD3) in uraemic HD patients. The present study aimed to assess the effect of long-term r-Hu EPO therapy for 12 months on plasma PTH, CT, 25-OHD3 and 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) in uraemic HD patients.
authors.affiliation: Department of Nephrology, Silesian University School of Medicine, Katowice, Poland.
authors.forename: F
authors.initials: F
authors.lastname: Kokot
authors.forename: A
authors.initials: A
authors.lastname: Wiecek
authors.forename: W
authors.initials: W
authors.lastname: Marcinkowski
authors.forename: H
authors.initials: H
authors.lastname: Schmidt-Gayk
authors.forename: R
authors.initials: R
authors.lastname: Rudka
authors.forename: J
authors.initials: J
authors.lastname: Trembecki
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D011994:Recombinant Proteins / Q000627:therapeutic use; D012016:Reference Values; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000628:therapy*
chemical_list: D006728:Hormones; D011994:Recombinant Proteins; D004921:Erythropoietin; D000469:Alkaline Phosphatase; D002118:Calcium