Therapeutic effect of the D2-dopamine agonist bromocriptine on acute and relapsing experimental allergic encephalomyelitis.
We examined the effect of bromocriptine (BCR) treatment on the duration and severity of neurological symptoms of acute experimental allergic encephalomyelitis (EAE), an animal model for demyelinating diseases, particularly multiple sclerosis. To mimic the clinical situation, BCR treatment was started after the onset of clinical signs. Furthermore, the effect of BCR treatment on the course of a chronic relapsing form of EAE was studied. BCR was injected at daily intervals in a dose that resulted in sustained suppression of plasma concentrations of prolactin, a pituitary hormone that plays a role in immunoregulation. In acute EAE, BCR therapy reduced both severity and duration of the clinical signs. In chronic relapsing EAE, BCR treatment did not affect the severity and duration of the first attack, but reduced the duration of the subsequent, second attack. Thus, BCR treatment improves the clinical course in animals with ongoing disease. These findings may have implications for the search for new therapeutic approaches in multiple sclerosis.
Dijkstra
C D
CD
Department of Histology, Research Institute of Neurosciences, Amsterdam, The Netherlands.
van der Voort
E R
ER
De Groot
C J
CJ
Huitinga
I
I
Uitdehaag
B M
BM
Polman
C H
CH
Berkenbosch
F
F
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D007108:Immune Tolerance / Q000187:drug effects; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D011388:Prolactin / Q000097:blood; D051381:Rats; D011917:Rats, Inbred Lew; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000502:physiology; D012008:Recurrence
D017448:Receptors, Dopamine D2; D001971:Bromocriptine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin