Chronic neutropenia associated with C2 and C9 deficiency.
A Japanese male with a deficiency of the second and ninth components of complement associated with chronic idiopathic neutropenia is presented. In this case the second component of complement is totally deficient while the ninth component is approximately half that of normal control. Neutrophil granulocytes are constantly few, but this case shows no evidence of susceptibility to either viral or bacterial infections. His HLA type is different from that of Caucasians, suggesting that the genetic abnormality responsible for the complement deficiency of this Japanese case is different from that seen in Caucasian patients.
Kaneko
Y
Y
First Department of Medicine, University of Tokyo, Japan.
Tsukamoto
A
A
Uwatoko
S
S
Kurokawa
K
K
Maeda
H
H
Kuwata
S
S
Tokunaga
K
K
Juji
T
T
D000328:Adult; D002908:Chronic Disease; D003175:Complement C2 / Q000172:deficiency*; D003186:Complement C9 / Q000172:deficiency*; D005805:Genes, MHC Class I; D006239:Haplotypes; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000209:etiology*
D003175:Complement C2; D003186:Complement C9