Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of treatment with propylthiouracil in children.
Propylthiouracil, which is commonly used in the treatment of hyperthyroidism, has been associated in adults with antineutrophil cytoplasmic autoantibody, a serologic marker of vasculitis. Severe renal disease has not been reported as a complication of therapy with this drug. We report severe antineutrophil cytoplasmic autoantibody-positive vasculitis in children receiving propylthiouracil, as well as rapidly progressive crescentic glomerulonephritis after administration of this drug.
Vogt
B A
BA
Department of Pediatrics, University of Minnesota, Minneapolis.
Kim
Y
Y
Jennette
J C
JC
Falk
R J
RJ
Burke
B A
BA
Sinaiko
A
A
D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008297:Male; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D011441:Propylthiouracil