title: Brodimoprim in acute respiratory tract infections.
abstract: Brodimoprim was studied in the treatment of acute respiratory tract infections in hospitalized, basically healthy, military conscripts. Its efficacy and tolerance were compared to those of doxycycline in a clinical randomized double-blind trial. 60 pts. were divided into two equally large groups. One group received brodimoprim, 400 mg as a loading dose followed by 200 mg daily, for 10 days. The other group received doxycycline, 200 mg as a loading dose followed by 100 mg daily, for 10 days. In the brodimoprim group, 23 patients (77%) were cured, 5 patients (16%) improved and 2 patients (6%) were considered failures. In the doxycycline group, 26 patients (87%) were cured, 3 patients (10%) improved and 1 patient (3%) did not respond. The only side effect in the whole study was moderate diarrhea in 1 patient in the brodimoprim group. Clinically and according to the normalization of laboratory values, the two drugs tested were equally effective.
authors.affiliation: Central Military Hospital, Helsinki, Finland.
authors.forename: H A
authors.initials: HA
authors.lastname: Salmi
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001831:Body Temperature; D003371:Cough / Q000188:drug therapy; D004311:Double-Blind Method; D004318:Doxycycline / Q000494:pharmacology / Q000627:therapeutic use; D004361:Drug Tolerance; D006801:Humans; D007902:Length of Stay; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D009175:Mycoplasma Infections / Q000097:blood / Q000188:drug therapy; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D014295:Trimethoprim / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014777:Virus Diseases / Q000097:blood / Q000188:drug therapy
chemical_list: D014295:Trimethoprim; D004318:Doxycycline; C037079:brodimoprim