title: Tricyclic heteroaromatic systems pyrazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.
abstract: The synthesis and the benzodiazepine receptor activity of some pyrazolo[1,5-a]quinoxalines bearing various substituents on the tricyclic heteroaromatic system are reported. Only one of the tested compounds showed some receptor affinity.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Colotta
authors.forename: L
authors.initials: L
authors.lastname: Cecchi
authors.forename: D
authors.initials: D
authors.lastname: Catarzi
authors.forename: G
authors.initials: G
authors.lastname: Conti
authors.forename: G
authors.initials: G
authors.lastname: Filacchioni
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: L
authors.initials: L
authors.lastname: Giusti
authors.forename: A
authors.initials: A
authors.lastname: Lucacchini
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002707:Chlordiazepoxide / Q000494:pharmacology; D005445:Flunitrazepam / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
chemical_list: D011720:Pyrazoles; D011810:Quinoxalines; D011963:Receptors, GABA-A; D005445:Flunitrazepam; D002707:Chlordiazepoxide