title: An autopsy case of Binswanger's disease without hypertension and associated with cerebral infarction in the terminal stage.
abstract: We report here an autopsy case of Binswanger's disease (BD) without hypertension and associated with cerebral infarction in the terminal stage. The female patient, who was 74 years old at the time of death, had initially demonstrated manic-depressive disorder-like mental disorder, followed by dementia and neurological deficits. A brain CT scan showed white matter low attenuation bilaterally and symmetrically. BD was clinically diagnosed despite the lack of hypertension. In the terminal stage, she suffered an infarction in the left anterior cerebral artery region, and died of pneumonia. Neuropathologically, we found the infarction of the left anterior cerebral artery region, demyelination, fibrillary gliosis, lacunae and arteriosclerosis of the small arteries and arterioles in the white matter.
authors.affiliation: Department of Psychiatry, Shimane Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iijima
authors.forename: H
authors.initials: H
authors.lastname: Ishino
authors.forename: H
authors.initials: H
authors.lastname: Seno
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: S
authors.initials: S
authors.lastname: Haruki
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000235:genetics / Q000473:pathology*; D002536:Cerebral Arteries / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000473:pathology*; D002537:Intracranial Arteriosclerosis / Q000235:genetics / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination; D013788:Thalamus / Q000473:pathology; D014057:Tomography, X-Ray Computed