title: Measles virus-specific functional antibody responses and viremia during acute measles.
abstract: Antibody titers measured in functional and immunofluorescent assays were compared with proportions of peripheral blood mononuclear cells infected with measles virus in 8 adults with measles. In addition, a syncytium inhibition assay (SIA) for measuring neutralizing antibody using low-passage virus was compared with a standard plaque neutralization test (PNT). Antibody-dependent cellular cytotoxicity (ADCC) antibody rose later but attained higher titer than neutralizing, antibody-dependent complement-mediated lysis, IgM, or IgG antibodies. When titer changes between specimens from each patient obtained on different days were compared, only ADCC (r = .81, P = .026) and IgM (r = .81, P = .027) antibodies correlated with reductions in viremia. SIA and PNT correlated well (r = .93, P < .001). ADCC may be an important defense against measles. The delay in ADCC antibody relative to other antibodies is unique among viruses studied. The SIA is a useful alternative to the PNT for measuring measles neutralizing antibody.
authors.affiliation: Department of Medicine, College of Medicine, University of California, Irvine, Orange 92668.
authors.forename: D N
authors.initials: DN
authors.lastname: Forthal
authors.forename: G
authors.initials: G
authors.lastname: Landucci
authors.forename: A
authors.initials: A
authors.lastname: Habis
authors.forename: M
authors.initials: M
authors.lastname: Zartarian
authors.forename: J
authors.initials: J
authors.lastname: Katz
authors.forename: J G
authors.initials: JG
authors.lastname: Tilles
mesh_terms: D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D015726:Giant Cells / Q000382:microbiology; D006801:Humans; D008297:Male; D008457:Measles / Q000276:immunology* / Q000382:microbiology; D008459:Measles virus / Q000276:immunology*; D009500:Neutralization Tests; D014766:Viremia / Q000276:immunology* / Q000382:microbiology
chemical_list: D000914:Antibodies, Viral