Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
de Sauvage
F J
FJ
Department of Molecular Biology, Genentech, South San Francisco, California 94080.
Hass
P E
PE
Spencer
S D
SD
Malloy
B E
BE
Gurney
A L
AL
Spencer
S A
SA
Darbonne
W C
WC
Henzel
W J
WJ
Wong
S C
SC
Kuang
W J
WJ
D000595:Amino Acid Sequence; D000741:Anemia, Aplastic / Q000473:pathology; D000818:Animals; D001483:Base Sequence; D001792:Blood Platelets / Q000166:cytology*; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D003001:Cloning, Molecular; D004921:Erythropoietin / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008533:Megakaryocytes / Q000166:cytology*; D051379:Mice; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000378:metabolism* / Q000502:physiology; D011994:Recombinant Proteins / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D013552:Swine; D013926:Thrombopoietin / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D014018:Tissue Distribution
D008024:Ligands; D011971:Receptors, Immunologic; D011994:Recombinant Proteins; D004921:Erythropoietin; D013926:Thrombopoietin