title: Carbonic anhydrase inhibitors from the pericarps of Punica granatum L.
abstract: Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin I (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure-activity relationship of inhibitory effects on CA is discussed.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Satomi
authors.forename: K
authors.initials: K
authors.lastname: Umemura
authors.forename: A
authors.initials: A
authors.lastname: Ueno
authors.forename: T
authors.initials: T
authors.lastname: Hatano
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: T
authors.initials: T
authors.lastname: Noro
mesh_terms: D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000378:metabolism; D002417:Cattle; D047348:Hydrolyzable Tannins / Q000302:isolation & purification* / Q000494:pharmacology; D007700:Kinetics; D009596:Nitrophenols / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013634:Tannins / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D047348:Hydrolyzable Tannins; D009596:Nitrophenols; D010936:Plant Extracts; D013634:Tannins; C013515:ellagitannin; C553162:granatin B; C008642:4-nitrophenyl acetate; D002256:Carbonic Anhydrases