Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
Alzheimer's disease is characterized by the deposition of beta-protein (A beta) as amyloid. Recently, it was found that A beta is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to A beta form amyloid-like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to A beta 1-40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.
Wisniewski
T
T
Department of Pathology, New York University Medical Center, NY 10016.
Castano
E
E
Ghiso
J
J
Frangione
B
B
D000544:Alzheimer Disease / Q000378:metabolism*; D000595:Amino Acid Sequence; D000682:Amyloid / Q000096:biosynthesis*; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism
D000682:Amyloid; D016229:Amyloid beta-Peptides; D010455:Peptides