CD8 and antigen-specific T cell adhesion cascades.
Activation of T cells involves both the antigen-specific T cell receptor and a number of additional accessory receptors. For cytotoxic T lymphocytes these include CD8, LFA-1 and VLA receptors. Recent studies have demonstrated that these receptors become activated to mediate adhesion upon crosslinking of the T cell receptor, and can deliver co-stimulatory signals upon binding their ligands. Rather than being redundant adhesion/co-signalling systems, these various receptors participate in a cascade of adhesion and signalling events leading to full activation of cellular responses.
O'Rourke
A M
AM
Division of Membrane Biology, Medical Biology Institute, La Jolla, CA 92037.
Ybarrondo
B
B
Mescher
M F
MF
D000818:Animals; D000941:Antigens / Q000276:immunology*; D016827:CD8 Antigens / Q000502:physiology*; D002448:Cell Adhesion; D006801:Humans; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1 / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000502:physiology*
D000941:Antigens; D016827:CD8 Antigens; D016169:Lymphocyte Function-Associated Antigen-1; D011948:Receptors, Antigen, T-Cell