title: Disposition of enantiomers of sulpiride in humans and rats.
abstract: Pharmacokinetics of sulpiride enantiomers after intravenous administration of (+/-)-, (+)-, and (-)-sulpiride was examined in humans and rats. Pharmacokinetics profiles were similar in (+)- and (-)-enantiomers after intravenous administration of (+/-)-sulpiride. Metabolic inversion at a chiral centre was not observed after intravenous administration of each enantiomer in rats.
authors.affiliation: Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kamizono
authors.forename: N
authors.initials: N
authors.lastname: Inotsume
authors.forename: S
authors.initials: S
authors.lastname: Fukushima
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008566:Membranes / Q000378:metabolism; D008875:Middle Aged; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013469:Sulpiride / Q000378:metabolism / Q000493:pharmacokinetics*; D014316:Tritium
chemical_list: D014316:Tritium; D013469:Sulpiride