title: Effect of weaning on oxygen consumption and cardiovascular function. A comparison of continuous flow and demand valve systems.
abstract: This study compared the continuous positive airways pressure mode of the demand valve system of the Engstrom Erica ventilator with a custom-made continuous flow continuous positive airways pressure system in terms of the oxygen cost of breathing during weaning from mechanical ventilation. Ten consecutive patients in our intensive care unit, with thermodilution pulmonary artery flotation catheters in situ, were studied. Measurements were carried out under steady-state conditions, initially when breathing spontaneously with continuous positive airways pressure via the Erica and then when transition to the continuous flow system was achieved. There were no significant differences between the two methods of providing continuous positive airways pressure in terms of the measured and derived physiological variables studied, with the exception of oxygen consumption. Oxygen consumption with the continuous flow system was significantly less than with the Erica (142.8 (SEM 31.4) ml.min-1.m-2 compared with 165.8 (SEM 30.5) ml.min-1.m-2, p < 0.05). This difference reflects the reduced oxygen cost of breathing when the custom-made continuous flow system was used during weaning.
authors.affiliation: Department of Anaesthesia, University of Liverpool.
authors.forename: P C
authors.initials: PC
authors.lastname: Ip Yam
authors.forename: I R
authors.initials: IR
authors.lastname: Appadurai
authors.forename: W J
authors.initials: WJ
authors.lastname: Kox
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D011175:Positive-Pressure Respiration / Q000379:methods*; D015300:Ventilator Weaning