title: The use of Doppler velocimetry of the umbilical artery before 24 weeks' gestation to screen for high-risk pregnancies.
abstract: OBJECTIVE
  To describe the prevalence and natural history of absent end-diastolic velocities (AEDV) in the umbilical artery of the fetus between 16 and 24 weeks' gestation, and to evaluate its role as a screening test.
  
  
  METHODS
  Population-based descriptive study.
  
  
  METHODS
  Tygerberg Hospital, Tygerberg, South Africa. The hospital serves a population from the lower socio-economic bracket.
  
  
  METHODS
  Doppler velocimetry was performed at routine ultrasound examinations for confirmation of gestational age in 496 women.
  
  
  METHODS
  The occurrence of perinatal death, small-for-gestational-age (SGA) babies and proteinuric hypertension.
  
  
  RESULTS
  Forty-four (8.9%) patients had AEDVs at the first examination, but AEDV persisted in only 1. In this case, severe proteinuric hypertension developed unexpectedly at 29 weeks' gestation and the fetus needed delivery because of persistent late decelerations of the fetal heart rate pattern. There was a significant association between the group with AEDV at first examination and the development of proteinuric hypertension (P < 0.05), but no association with SGA babies. The association with proteinuric hypertension was too weak to be of clinical use.
  
  
  CONCLUSIONS
  Doppler velocimetry of the umbilical artery, performed along with routine ultrasound examination to confirm gestational age, is not of use as a screening test for identifying high-risk pregnancies.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Stellenbosch, Tygerberg, CP.
authors.forename: R C
authors.initials: RC
authors.lastname: Pattinson
authors.forename: K
authors.initials: K
authors.lastname: Norman
authors.forename: H J
authors.initials: HJ
authors.lastname: Odendaal
mesh_terms: D001783:Blood Flow Velocity; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008403:Mass Screening; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011446:Prospective Studies; D014469:Umbilical Arteries / Q000502:physiology*