The breadth of action of the 5-HT3 receptor antagonists.
The breadth of action of 5-HT3 receptor antagonists to modify animal behaviour may at first appear surprising but is revealing of a widespread role for 5-HT in moderating behaviour. It will prove of considerable interest to establish the role of the 5-HT3 receptor antagonists in the treatment of human illness. Such data would not merely be relevant to the design of new drug therapies but would also allow an important insight into the value of the animal models of human psychiatric disease.
Costall
B
B
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, UK.
D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy / Q000523:psychology; D001921:Brain / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D013287:Illicit Drugs; D001523:Mental Disorders / Q000188:drug therapy* / Q000523:psychology; D011939:Mental Recall / Q000187:drug effects; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000523:psychology
D013287:Illicit Drugs; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists