title: Renal adaptation to the failing heart. Understanding the cascade of responses.
abstract: Progressive systolic dysfunction of the heart results in a broad array of physiologic compensatory mechanisms within the kidney. These mechanisms are primarily stimulated by diminution of the effective arterial blood volume and resultant activation of a biochemical cascade of neurohormonal responses, including activation of the renin-angiotensin-aldosterone system and enhanced release of norepinephrine, arginine vasopressin, prostaglandins, endothelin, and atrial natriuretic peptide. The interaction of these neurohormonal systems within the kidney is complex. Vasoconstriction induced by angiotensin II, arginine vasopressin, and catecholamines may decrease renal perfusion by both endocrine and neural actions. In contrast, systemic pressures may rise, which may facilitate perfusion.
authors.affiliation: Department of Medicine, University of Texas Health Science Center at San Antonio.
authors.forename: D J
authors.initials: DJ
authors.lastname: Riley
authors.forename: M
authors.initials: M
authors.lastname: Weir
authors.forename: G L
authors.initials: GL
authors.lastname: Bakris
mesh_terms: D000222:Adaptation, Physiological; D000450:Aldosterone / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D001127:Arginine Vasopressin / Q000502:physiology; D009320:Atrial Natriuretic Factor / Q000502:physiology; D001810:Blood Volume; D016232:Endothelins / Q000502:physiology; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology*; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology*; D009638:Norepinephrine / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D012079:Renal Circulation; D012084:Renin-Angiotensin System / Q000502:physiology; D013599:Systole
chemical_list: D016232:Endothelins; D011453:Prostaglandins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine