[The participation of the prostacyclin-thromboxane system in the mechanism of the action of calcium antagonists].
The experiments with isolated rat aortic circular segments have shown that vasocyclin (natural prostacyclin), verapamil, and diltiazem cause the relaxation of vascular smooth muscles during potassium-induced contracture. The impaired endothelium and acetylsalicylic acid-induced blockade of cyclooxygenase dramatically reduce the relaxant action of verapamil and diltiazem under these conditions. It is concluded that the system of prostaglandin synthesis plays an important role in the vasodilator effects of calcium antagonist.
Kazanova
G V
GV
Chichkanov
G G
GG
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D013931:Thromboxanes / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D002121:Calcium Channel Blockers; D013931:Thromboxanes; D011464:Epoprostenol
Ob uchastii prostatsiklin-tromboksanovoĭ sistemy v mekhanizme deĭstviia antagonistov kal'tsiia.