title: Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine.
abstract: We describe the limitations on studying the interactions of drugs of abuse in humans. Two 'acute' studies were carried out. In the first study, the administration of alcohol/placebo with cocaine showed the possibility of identifying the euphoric effect of the drugs by the EEG power spectra analysis in terms of enhancement of alpha- and beta-wave activity. The results of the second study, in which cocaine and buprenorphine were administered, show the existence of low-dose interactions and the influence of buprenorphine on craving for cocaine.
authors.affiliation: Department of Psychiatry, Catholic University, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mannelli
authors.forename: L
authors.initials: L
authors.lastname: Janiri
authors.forename: E
authors.initials: E
authors.lastname: Tempesta
authors.forename: R T
authors.initials: RT
authors.lastname: Jones
mesh_terms: D000513:Alpha Rhythm / Q000187:drug effects; D001611:Beta Rhythm / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002047:Buprenorphine / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005059:Euphoria; D005260:Female; D006801:Humans; D008297:Male; D015878:Mydriasis / Q000139:chemically induced; D011336:Probability; D019966:Substance-Related Disorders / Q000523:psychology*
chemical_list: D000431:Ethanol; D002047:Buprenorphine; D003042:Cocaine