[The dynamic circadian mobility of rats under acute and chronic propranolol administration].
Acute administration of propranolol, 1 mg/kg i.p., decreased the amplitude of locomotor circadian rhythm in rats and shifted its acrophase to late night hours. After chronic (10-day) treatment with the drug, morning rises in locomotion after turning out the light became less frequent. The circadian rhythm reorganization observed may depend on the effects of the beta-adrenoblocker on its specific receptors in the hypothalamic suprachiasmatic nuclei and/or the pineal gland.
Arushanian
E B
EB
Beĭer
E V
EV
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D017440:Photoperiod; D011433:Propranolol / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors
D011433:Propranolol
Dinamika sutochnoĭ podvizhnosti krys pri ostrom i khronicheskom vvedenii propranolola.