title: Methionine as translation start signal: a review of the enzymes of the pathway in Escherichia coli.
abstract: Methionine is the universal translation start but the first methionine is removed from most mature proteins. This review focuses on our present knowledge of the five enzymes sustaining the methionine pathway in translation initiation in Escherichia coli: methionyl-tRNA synthetase, methionyl-tRNA(fMet) formyltransferase, peptidyl-tRNA hydrolase, peptide deformylase and methionine aminopeptidase. The possible significance of retaining methionine as initiation signal is discussed.
authors.affiliation: Laboratoire de Biochimie, URA-CNRS no 240, Palaiseau, France.
authors.forename: T
authors.initials: T
authors.lastname: Meinnel
authors.forename: Y
authors.initials: Y
authors.lastname: Mechulam
authors.forename: S
authors.initials: S
authors.lastname: Blanquet
mesh_terms: D000217:Acyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000581:Amidohydrolases; D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D019877:Hydroxymethyl and Formyl Transferases; D008715:Methionine / Q000378:metabolism*; D008718:Methionine-tRNA Ligase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D063208:Methionyl Aminopeptidases; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D015183:Restriction Mapping; D013379:Substrate Specificity
chemical_list: D008715:Methionine; D019877:Hydroxymethyl and Formyl Transferases; C021561:methionyl-tRNA formyltransferase; D000217:Acyltransferases; D002265:Carboxylic Ester Hydrolases; C019674:aminoacyl-tRNA hydrolase; D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases; D000581:Amidohydrolases; C084507:peptide deformylase; D008718:Methionine-tRNA Ligase