title: Intravenous immunoglobulin in the treatment of Salmonella typhimurium infections in preterm neonates.
abstract: The purpose of this study was to determine the role of intravenous immunoglobulin (IVIG) administration in preterm neonates with S. typhimurium infection. A randomized trial of 47 preterm neonates with intestinal or extraintestinal S. typhimurium infection was performed. Neonates were randomly divided into two groups: 22 neonates were only given cefoperazone (group 1); 25 neonates were given cefoperazone plus IVIG (group 2). IVIG was given at a dose of 500 mg/kg on days 1, 2, 3, and 8 after entry into the study. Following treatment, bacteremia, complications, mortality rate, recovery time, and duration of antimicrobial therapy were evaluated in two groups. Bacteremia was found in 31.4% in group 1 and 8% in group 2 (P < .05); complications developed in 81.8% in group 1 and 16% in group 2 (P < 0.01); mortality was 40.9% in group 1 and 12% in group 2 (P < .05). Recovery took 15 days in group 1 and 8 days in group 2 (P < .01). The duration of antimicrobial therapy was 20 days in group 1 and 14 days in group 2 (P < .01). We conclude that IVIG treatment in combination with antibiotics in preterm neonates with S. typhimurium infection reduces the complications, mortality rate, and duration of therapy.
authors.affiliation: Department of Pediatrics, Medical Faculty, Cumhuriyet University, Sivas, Turkey.
authors.forename: A S
authors.initials: AS
authors.lastname: Gökalp
authors.forename: H B
authors.initials: HB
authors.lastname: Toksoy
authors.forename: S
authors.initials: S
authors.lastname: Türkay
authors.forename: M Z
authors.initials: MZ
authors.lastname: Bakici
authors.forename: R
authors.initials: R
authors.lastname: Kaya
mesh_terms: D002438:Cefoperazone / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D012480:Salmonella Infections / Q000188:drug therapy*; D012486:Salmonella typhimurium
chemical_list: D016756:Immunoglobulins, Intravenous; D002438:Cefoperazone