title: Effect of nutritional status on the incidence of infection in childhood cancer.
abstract: In 52 children with cancer, the effect of nutritional status on infection rate was studied. Thirty-two children had solid tumors and 20 had leukemia. Their treatment courses were arbitrarily divided into 3-month periods. Where treatment lasted for 9 months or more, the initial Nutritional Status score was correlated with infection rate during the subsequent 3-month period. Among the leukemic patients, a statistically significant inverse correlation (P < 0.05) was found between nutritional status and ensuing infection rate. No such correlation was found in children with solid tumors. Based on these findings, we recommend nutritional support to children with leukemia during chemotherapy to attempt to reduce the infection rate.
authors.affiliation: Department of Paediatrics, King Edward Medical College, Lahore, Pakistan.
authors.forename: M M
authors.initials: MM
authors.lastname: Taj
authors.forename: A D
authors.initials: AD
authors.lastname: Pearson
authors.forename: D B
authors.initials: DB
authors.lastname: Mumford
authors.forename: L
authors.initials: L
authors.lastname: Price
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D004198:Disease Susceptibility / Q000209:etiology; D004750:Enteral Nutrition; D005069:Evaluation Studies as Topic; D005527:Food, Fortified; D006801:Humans; D015994:Incidence; D007239:Infections / Q000453:epidemiology / Q000209:etiology*; D007938:Leukemia / Q000150:complications; D009369:Neoplasms / Q000150:complications*; D009503:Neutropenia / Q000150:complications; D009748:Nutrition Disorders / Q000150:complications* / Q000628:therapy; D009752:Nutritional Status; D010288:Parenteral Nutrition; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome