title: Detection and localization of perfluorodecalin in the human eye by fluorine 19 magnetic resonance.
abstract: Perfluorocarbons are applied as heavy liquids during vitreoretinal surgery. They are removed again intraoperatively because of possible harmful long-term effects. Following vitreoretinal surgery, residual perfluorodecalin (PFD) was detected in four eyes and localized in two others by fluorine 19 magnetic resonance (19F-MR). In vitro analysis of 19F-MR spectra shows that chemical shift artifacts can be avoided much better with PFD than with perfluorotributylamine and perfluoroctane. Therefore, PFD localization by 19F-MR imaging is superior to that of perfluorotributylamine and perfluoroctane. This examination can be performed on currently employed magnetic resonance imaging systems equipped with a fluorine channel. In the event of significant inadvertent residual quantities of PFD and obscured media, 19F-MR may specifically detect and localize PFD.
authors.affiliation: Augenklinik, Freie Universität, Berlin, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Noske
authors.forename: B
authors.initials: B
authors.lastname: Gewiese
authors.forename: A
authors.initials: A
authors.lastname: Schilling
authors.forename: D
authors.initials: D
authors.lastname: Stiller
authors.forename: K J
authors.initials: KJ
authors.lastname: Wolf
authors.forename: M H
authors.initials: MH
authors.lastname: Foerster
mesh_terms: D000368:Aged; D002648:Child; D005128:Eye Diseases / Q000378:metabolism / Q000601:surgery; D005260:Female; D005466:Fluorocarbons / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012164:Retinal Diseases / Q000378:metabolism / Q000601:surgery; D014822:Vitreous Body / Q000737:chemistry* / Q000601:surgery
chemical_list: D005466:Fluorocarbons; C008805:perfluorodecalin