Stimulation of phagocytosis against Staphylococcus aureus by teicoplanin and vancomycin.
The constructive interference of teicoplanin with phagocytosis of Staphylococcus aureus by murine macrophages and human neutrophils, studied in vivo and in vitro respectively, was compared with that of vancomycin. Both teicoplanin and vancomycin increased the phagocytosis by macrophages. All the concentrations of teicoplanin increased the phagocytosis by neutrophils, but only the highest concentrations of vancomycin (50 mg/l and 100 mg/l) had this effect, greater values being found with teicoplanin in all cases.
Pedrera
M I
MI
Departamento de Fisiología Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Pérez
F
F
Rodríguez
A B
AB
Barriga
C
C
D000818:Animals; D006801:Humans; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus; D013268:Stimulation, Chemical; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
D017334:Teicoplanin; D014640:Vancomycin