Solitary congenital self-healing reticulohistiocytosis.
Congenital self-healing reticulohistiocytosis (CSHR) was first described in 1973 by Hashimoto and Pritzker. Since then, both multiple and solitary forms have been described. We report a further case of solitary congenital self-healing reticulohistiocytosis. CSHR is a rare disorder which frequently presents a diagnostic dilemma in the newborn. Nodular forms of systemic Langerhans cell histiocytosis may present in a manner similar to CSHR. Because their differentiation on histopathological grounds is impossible, physical examination, laboratory investigations, and follow-up are necessary to ensure a lack of systemic involvement. Although previously thought to represent a rare variant of CSHR, solitary lesions of CSHR account for almost 25% of reported cases. A review of the literature relating to solitary CSHR, and a consideration of the differential diagnosis of a solitary congenital nodule, are also presented.
Bernstein
E F
EF
Thomas Jefferson University, Department of Dermatology, Philadelphia, PA 19107-5541.
Resnik
K S
KS
Loose
J H
JH
Halcin
C
C
Kauh
Y C
YC
D006644:Histiocytes / Q000473:pathology / Q000648:ultrastructure; D015616:Histiocytosis, Non-Langerhans-Cell / Q000151:congenital* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009418:S100 Proteins / Q000032:analysis
D009418:S100 Proteins