Mechanism of hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats: reduction of cholesterol absorption and increase of plasma cholesterol removal.
The content of cholesterol in the serum and liver of male Wistar rats fed, for the period of 8 weeks shortly after weaning, a diet containing 0.3% of cholesterol was reduced by 33 and 27% by the addition of 5% of dried oyster mushroom powder. Although the level of serum triacylglycerols was not affected by oyster mushroom, their content in liver of rats on mushroom diet was reduced by 41%. Very-low-density lipoproteins and low-density lipoproteins participated by 55 and 38%, respectively, in the total reduction of serum cholesterol. Cholesterol content in high-density lipoproteins was not significantly affected by oyster mushroom. Cholesterol absorption as determined by dual-isotope plasma ratio method was significantly reduced by 14% with oyster mushroom diet. Similarly, this diet increased by 42% the fractional catabolic rate of cholesterol determined by the analysis of decay curve of [4-14C]cholesterol.
Bobek
P
P
Research Institute of Nutrition, Bratislava.
Ozdin
L
L
Kuniak
L
L
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000032:analysis / Q000097:blood*; D002791:Cholesterol, Dietary / Q000493:pharmacokinetics*; D006207:Half-Life; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000517:prevention & control; D007408:Intestinal Absorption; D008099:Liver / Q000737:chemistry; D008297:Male; D011124:Polyporaceae; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D014280:Triglycerides; D002784:Cholesterol