Diagnostic value of the tumor markers in breast cancer.
The use of the most common tumor markers in breast cancer was reassessed in terms of cost effectiveness and the validity of their predictive information during the evaluation of the patients. Sera from 159 patients were studied. Acceptable diagnostic specificity was found only for CA 15-3. In predicting the presence of metastases the combination of CA 15-3 and CEA was observed to correlate with lymph node metastases. Introduction of MCA did not result in diagnostic improvement. Our results suggest that in practice a diagnostic panel for breast cancer can be confined to CA 15-3 and CEA.
Yasasever
V
V
I.U. Oncology Institute, Istambul, Turkey.
Karaloglu
D
D
Ertürk
N
N
Dalay
N
N
D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood* / Q000191:economics; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000191:economics / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000097:blood* / Q000191:economics; D002277:Carcinoma / Q000175:diagnosis / Q000191:economics / Q000473:pathology / Q000556:secondary; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; C057387:mucinous carcinoma-associated antigen