title: Quality assurance in fractionated stereotactic radiotherapy.
abstract: The recent development of fractionated stereotactic radiotherapy (SRT), which utilises the relocatable Gill-Thomas-Cosman frame (GTC 'repeat localiser'), requires comprehensive quality assurance (QA). This paper focuses on those QA procedures particularly relevant to fractionated SRT treatments, and which have been derived from the technique used at the Royal Marsden Hospital. They primarily relate to the following: (i) GTC frame fitting, initially in the mould room, and then at each imaging session and treatment fraction; (ii) checking of the linear accelerator beam geometry and alignment lasers; and (iii) setting up of the patient for each fraction of treatment. The precision of the fractionated technique therefore depends on monitoring the GTC frame relocation at each fitting, checking the accuracy of the radiation isocentre of the treatment unit, its coincidence with the patient alignment lasers and the adjustments required to set the patient up accurately. The results of our quality control checks show that setting up to a mean radiation isocentre using precisely set-up alignment lasers can be achievable to within 1 mm accuracy. When this is combined with a mean GTC frame relocatability of 1 mm on the patient, a 2-mm allowance between the prescribed isodose surface and the defined target volume is a realistic safety margin for this technique.
authors.affiliation: Physics Department, Royal Marsden Hospital, London, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: Warrington
authors.forename: R W
authors.initials: RW
authors.lastname: Laing
authors.forename: M
authors.initials: M
authors.lastname: Brada
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D002138:Calibration; D004867:Equipment Design; D006801:Humans; D007834:Lasers; D008961:Models, Structural; D009064:Mouth Protectors; D011785:Quality Assurance, Health Care; D011786:Quality Control; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012015:Reference Standards; D014057:Tomography, X-Ray Computed