title: Intra-arterial hepatic carboplatin-based chemotherapy for ocular melanoma metastatic to the liver. Report of a phase II study.
abstract: OBJECTIVE
  ocular melanoma tends to metastasize to the liver, sparing for a long time the rest of the organism. Therefore, a regional treatment is especially indicated.
  
  
  METHODS
  eight patients with ocular melanoma metastatic to the liver were treated with intra-arterial hepatic carboplatin-based chemotherapy at the dose of 300 mg/m2 once every two weeks at an out-patient clinic. All the patients were submitted to laparotomy with surgical implantation of an arterial port device through the gastroduodenal artery.
  
  
  RESULTS
  the overall response rate was 38% with a median survival time of 15 months. The regimen was well tolerated and the principle toxicity was myelosuppression; any instance of hepatic and/or cholangitic damage was reported.
  
  
  CONCLUSIONS
  Carboplatin seems suitable for intra-arterial hepatic chemotherapy and active in ocular melanoma metastatic to the liver.
authors.affiliation: Oncology Department, Civil Hospital of Mantova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cantore
authors.forename: G
authors.initials: G
authors.lastname: Fiorentini
authors.forename: E
authors.initials: E
authors.lastname: Aitini
authors.forename: B
authors.initials: B
authors.lastname: Davitti
authors.forename: G
authors.initials: G
authors.lastname: Cavazzini
authors.forename: C
authors.initials: C
authors.lastname: Rabbi
authors.forename: A
authors.initials: A
authors.lastname: Lusenti
authors.forename: M
authors.initials: M
authors.lastname: Bertani
authors.forename: C
authors.initials: C
authors.lastname: Morandi
authors.forename: V
authors.initials: V
authors.lastname: Benedini
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005134:Eye Neoplasms / Q000473:pathology*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D016190:Carboplatin