Adult T-cell leukaemia/lymphoma featuring a large granular lymphocyte leukaemia morphologically.
A 70-year-old man from an endemic area of human T-cell lymphotropic virus type I (HTLV-I) developed rapid generalized lymphadenopathy and abdominal tumours. The white blood cell count was 198.3 x 10(9)/l with 93% lymphocytes, 66.3% of which expressed large granular lymphocytes (LGLs). Bone marrow and lymph nodes were also infiltrated by LGLs. Surface markers were positive for CD4, CD25 and HLA-DR, and negative for CD3, CD8, CD16, CD56 and CD57. A monoclonal integration of HTLV-I proviral DNA was demonstrated on these LGLs by Southern blot hybridization analysis. This fact indicates that some adult T-cell leukaemia/lymphoma may morphologically present LGL leukaemia.
Sakamoto
Y
Y
Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
Kawachi
Y
Y
Uchida
T
T
Abe
T
T
Mori
M
M
Setsu
K
K
Indo
N
N
D000368:Aged; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007945:Leukemia, Lymphoid / Q000382:microbiology / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000473:pathology*; D008297:Male
D004279:DNA, Viral