title: Multicenter comparison of in vitro activities of FK-037, cefepime, ceftriaxone, ceftazidime, and cefuroxime.
abstract: In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less active against ceftazidime-resistant isolates of Enterobacter cloacae. The MIC90 of FK-037 for methicillin-resistant staphylococci was > 16 micrograms/ml.
authors.affiliation: Cleveland Clinic Foundation, Ohio 44195.
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: E H
authors.initials: EH
authors.lastname: Gerlach
authors.forename: P R
authors.initials: PR
authors.lastname: Murray
authors.forename: S D
authors.initials: SD
authors.lastname: Allen
authors.forename: C C
authors.initials: CC
authors.lastname: Knapp
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077723:Cefepime; D002442:Ceftazidime / Q000494:pharmacology; D015296:Ceftizoxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C079769:cefoselis; D002443:Ceftriaxone; D000077723:Cefepime; D002442:Ceftazidime; D015296:Ceftizoxime; D002444:Cefuroxime