[Jaundice secondary to intrahepatic deposit of light chains as a presenting form of multiple myeloma].
In the disease caused by deposit of light chains, nephropathy is the earlier and most frequent clinical manifestation; and although the liver is the extrarenal organ most frequently affected, its affection is rare without renal deposit of light chains. Bearing this in mind, we present the clinical and evolutive characteristics of a patient diagnosed of IgG Kappa multiple myeloma, whose first manifestation was a jaundice syndrome with intrahepatic deposit of light chains documented in the anatomopathologic study and in which, despite presenting renal failure, deposits of light chains were not observed in the renal biopsy. We review the medical literature on this topic.
Macías Robles
M D
MD
Servicio de Medicina Interna, Hospital San Agustín, Avilés, Asturias.
Navia-Osorio García-Braga
J M
JM
Menéndez Caro
J L
JL
Velasco Alonso
J
J
López Lagunas
I
I
D000368:Aged; D000369:Aged, 80 and over; D002780:Cholestasis, Intrahepatic / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis*
D007145:Immunoglobulin kappa-Chains
Ictericia secundaria a depósito intrahepático de cadenas ligeras como forma de presentación de un mieloma múltiple.