[Effect of ginseng on antiperoxidate injury in myocardium and erythrocytes in streptozocin-induced diabetic rats].
We have investigated the effect of ginseng on antiperoxidation in myocardium and erythrocytes of streptozocin-induced diabetic rats. In the group of ginseng administration (ginseng solution 0.2g/200g/day, lasting 15-16 days), there was a significant decrease in the level of fasting blood-glucose and lipid peroxide (LPO) in myocardium and erythrocytes, in comparing with that of model group, P < 0.05. The activity of superoxide dismutase (SOD) in myocardium and erythrocytes in group of ginseng administration was increased, P < 0.05, compared with that of model group and vitamin E treatment group. The mechanisms of antiperoxidation effect of ginseng might include the following: 1) By lowering the level of fasting blood-glucose, decreasing the rate of monosaccharide auto-oxidation and partially protecting the production of free radicals; 2) Elevating the activity of enzymatic free radicals scavenger in cells, such as SOD; 3) directly eliminating the superfluous free radicals.
Xie
Z C
ZC
Institute of Integrated TCM and WM, Tongji Medical University, Wuhan.
Qian
Z K
ZK
Liu
Z W
ZW
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D005894:Panax; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D013482:Superoxide Dismutase