[Eicosanoids in septic shock in rats].
In order to evaluate the role of eicosanoids in pathogenesis of septic shock, the dynamics of TxA2, PGE2 and peptidoleukotriene contents has been measured in the liver of rats with surgically induced septic shock (sesum resection). In the same time the general parameters have been followed up: survival, body temperature, hematocrit and glucose contents in the plasma of experimental animals. Aiming to differentiate the importance of some eicosanoids, immediately after surgery methyl prednisolone (phospholipase A2 inhibitor) or indomethacin (cyclooxigenase enzyme inhibitor) have been given. Based on own results the authors have concluded that in pathogenetic mechanisms of septic shock the main role have peptidoleukotrienes, lipooxygenase products of degradation of arachidonic acid.
Cernak
I
I
Vojnomedicinska akademija, Institut za medicinska istrazivanja.
Savić
J
J
Andelić
G
G
Radenković
D
D
D000818:Animals; D015777:Eicosanoids / Q000037:antagonists & inhibitors / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000188:drug therapy / Q000503:physiopathology*
D015777:Eicosanoids
Eikosanoidi u septickom soku kod pacova.