Intrahepatic cholestasis and biliary cirrhosis associated with extrahepatic Hodgkin's disease.
A 29-year-old male with supraclavicular Hodgkin's disease (Stage IA) developed intrahepatic cholestasis. Cholestasis with severe pruritus persisted while the Hodgkin's disease was brought into remission by radiotherapy. During ursodeoxycholic acid treatment jaundice and hypercholesterolaemia decreased and pruritus disappeared. However, 2 years after diagnosis the patient died of variceal haemorrhage. On autopsy no recurrence of Hodgkin's disease was found. The liver showed advanced biliary cirrhosis. Intrahepatic cholestasis in this patient persisted as a paraneoplastic phenomenon despite complete remission of Hodgkin's disease.
Jansen
P L
PL
Department of Medicine, Academic Medical Center, University of Amsterdam, Netherlands.
van der Lelie
H
H
D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D012074:Remission Induction; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D014580:Ursodeoxycholic Acid