[A study of T-lymphocyte subsets, IL-2 production and IL-2 receptor expression in peripheral blood lymphocytes in patients with nasopharyngeal carcinoma].
T lymphocyte subsets, IL-2 production and IL-2 receptor expression were detected in PBLs of 31 NPC patients and 28 normal subjects and of normal PBLs populations under the influence of serum of NPC patients. The results were as follows: CD4+ and IL-2 receptor expression, CD4+:CD8+ ratios and IL-2 production were significantly depressed and CD8+-significantly elevated in PBLs of NPC patients before radiation and of normal PBLs populations under the influence of the serum of NPC patients. CD8+ was significantly decreased and CD4+, IL-2 production and IL-2 receptor expression were depressed in patients after radiation. These suggest that cellular immunity and immunoregulation are impaired in NPC patients before and after radiation.
Tan
G L
GL
Second Clinical College of Hunan Medical University, Changsha.
D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2