title: Structural classification of the P450 superfamily based on consensus sequence comparison.
abstract: The novel method for classification of P450s has been proposed basing on consecutive multiple alignments of consensus sequences. A code can be assigned to each P450 amino acid sequence reflecting its relative distance from the corresponding consensus sequences at three hierarchical levels. Thus, only the principle of sequence similarity is chosen for classification without involving such criteria as enzymatic properties, phylogenetic assignment or chronology.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Archakov
authors.forename: K N
authors.initials: KN
authors.lastname: Degtyarenko
mesh_terms: D000465:Algorithms; D000818:Animals; D016384:Consensus Sequence; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000145:classification*; D006801:Humans; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D003577:Cytochrome P-450 Enzyme System