Teratogenic evaluation of di-n-butyl phthalate in rats.
Pregnant rats were given di-n-butyl phthalate (DBP) by gastric intubation at a dose of 0, 0.5, 0.63, 0.75 or 1.0 g/kg on days 7-15 of pregnancy. A significant decrease in the maternal body weight gain after treatment with DBP was found at a dose of 0.63 g/kg and above. Maternal death and complete resorption of implanted embryos in all the surviving dams were observed in the 1.0 g/kg group. Significantly increased incidence of postimplantation loss and decreased fetal weight were detected at doses of 0.63 and 0.75 g/kg. The incidence of fetuses with malformations was higher in the 0.63 and 0.75 g/kg groups than in the control group, and the difference was significant in the 0.75 g/kg group. Cleft palate were predominantly observed.
Ema
M
M
National Institute of Hygienic Sciences, Osaka Branch, Japan.
Amano
H
H
Itami
T
T
Kawasaki
H
H
D000014:Abnormalities, Drug-Induced; D000818:Animals; D003993:Dibutyl Phthalate / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D003993:Dibutyl Phthalate