Difficulties in the antenatal assessment of neonatal alloimmune thrombocytopenia.
In this paper we present a patient with an initially questionable history of neonatal alloimmune thrombocytopenia (NAT) due to materno-fetal HPA-1a (PLA1) incompatibility. No circulating antibodies were detectable in untreated maternal serum, but an adsorption/elution technique enabled the demonstration of the platelet-specific anti-HPA-1a (anti-PLA1) in maternal serum. Cordocentesis at 35 weeks of gestation revealed a fetal platelet count of 18 x 10(9)/l. Intrauterine platelet transfusion with HPA-1a (PLA1)-negative donor platelets was performed prior to cesarean section.
Marzusch
K
K
Department of Obstetrics and Gynecology, University of Tübingen, Germany.
Fischer
J
J
Dietl
J
J
Wiest
E
E
Völklein
K
K
Schnaidt
M
M
D016824:Antigens, Human Platelet / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology*
D016824:Antigens, Human Platelet; D007518:Isoantibodies