title: Long-term humoral and cellular immunity after vaccination with cell culture rabies vaccines in man.
abstract: To determine the duration of anti-rabies immunity, peripheral blood of 18 vaccinees was obtained between 2 and 14 years after immunization. Peripheral blood mononuclear cells (PBMC) and serum were tested for the presence of either rabies virus-specific antibodies or rabies antigen-specific proliferation. Neutralizing immunoglobulin class G anti-rabies virus antibodies could be detected in sera of all vaccinees, but not in 18 age- and sex-matched controls. Rabies antigen-induced proliferation of PBMCs from vaccinees was significantly higher than that of controls. The anti-rabies T and B cell response showed no time-dependent pattern. These results suggest the induction of a long-term immunity after rabies immunization according to pre- and post-exposure schedules with inactivated cell culture vaccines against rabies.
authors.affiliation: WHO Collaborating Centre for Reference and Research on Neurological Zoonosis, Universitätsklinikum Essen, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Thraenhart
authors.forename: E
authors.initials: E
authors.lastname: Kreuzfelder
authors.forename: M
authors.initials: M
authors.lastname: Hillebrandt
authors.forename: I
authors.initials: I
authors.lastname: Marcus
authors.forename: K
authors.initials: K
authors.lastname: Ramakrishnan
authors.forename: Z F
authors.initials: ZF
authors.lastname: Fu
authors.forename: B
authors.initials: B
authors.lastname: Dietzschold
mesh_terms: D000328:Adult; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D002642:Chick Embryo; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology; D011820:Rabies virus / Q000276:immunology; D013997:Time Factors; D014611:Vaccination
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D011819:Rabies Vaccines; C048844:anti-IgG