Disposition of enantiomers of sulpiride in humans and rats.
Pharmacokinetics of sulpiride enantiomers after intravenous administration of (+/-)-, (+)-, and (-)-sulpiride was examined in humans and rats. Pharmacokinetics profiles were similar in (+)- and (-)-enantiomers after intravenous administration of (+/-)-sulpiride. Metabolic inversion at a chiral centre was not observed after intravenous administration of each enantiomer in rats.
Kamizono
A
A
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
Inotsume
N
N
Fukushima
S
S
Nakano
M
M
Okamoto
Y
Y
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008566:Membranes / Q000378:metabolism; D008875:Middle Aged; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013469:Sulpiride / Q000378:metabolism / Q000493:pharmacokinetics*; D014316:Tritium
D014316:Tritium; D013469:Sulpiride