Liver metabolism during treatment with estradiol and natural progesterone.
Serum concentrations of sex hormone-binding globulin (SHBG), corticosteroid binding globulin (CBG), ceruloplasmin, lipoprotein A and liver enzymes were measured in 30 postmenopausal women treated with 2 mg micronized 17 beta-estradiol daily and micronized progesterone orally in doses of 50, 100 and 200 mg daily, as progestogen supplementation. The treatment lasted for 4 months. The serum levels of SHBG and CBG increased during treatment and a weak association between progesterone dosage and CBG was observed. Levels of lipoprotein A and liver enzymes did not change. It is concluded that micronized natural progesterone is an attractive means of progesterone supplementation in postmenopausal hormone replacement therapy without any liver-related side-effects.
Darj
E
E
Department of Obstetrics and Gynecology, Uppsala University, Sweden.
Axelsson
O
O
Carlström
K
K
Nilsson
S
S
von Schoultz
B
B
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D002570:Ceruloplasmin / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006038:Glyoxylates / Q000097:blood; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D012694:Serine / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000096:biosynthesis; D013997:Time Factors; D000637:Transaminases / Q000097:blood; D014156:Transcortin / Q000096:biosynthesis
D006038:Glyoxylates; D017270:Lipoprotein(a); D012738:Sex Hormone-Binding Globulin; D012694:Serine; D011374:Progesterone; D004958:Estradiol; D014156:Transcortin; D002570:Ceruloplasmin; D000637:Transaminases; D000410:Alanine Transaminase; C022636:serine-glyoxylate aminotransferase; D000469:Alkaline Phosphatase