title: Invasive Haemophilus influenzae infections in older children and adults in Seattle.
abstract: We recently saw two unusual manifestations of Haemophilus influenzae infection in adults in the Seattle area: fulminant sepsis in an otherwise-healthy man and three episodes of bacteremia in a woman with chronic liver disease. We retrospectively identified 79 bacteremic and 40 non-bacteremic cases of invasive H. influenzae infection developing in patients > or = 9 years of age between 1 January 1980 and 31 December 1990. The most common clinical presentations among patients with bacteremia included pneumonia (52%), septicemia (27%), meningitis (8%), gynecologic infection (5%), and epiglottitis (5%). Underlying illnesses were common in these patients, and overall mortality was 35.5%. Factors associated with mortality included underlying neurological disease, polymicrobial bacteremia, and advanced age. The clinical presentations of the 40 patients without bacteremia included soft-tissue abscesses (45%), lung abscesses (18%), peritonitis (13%), meningitis (8%), gynecologic infection (8%), epididymitis (5%), mastoiditis (3%), and osteomyelitis (3%). Thus H. influenzae disease has a variety of presentations and is associated with significant mortality in older children and adults. Further study is required to determine whether widespread administration of H. influenzae type b conjugate vaccine to infants will alter the development of subsequent disease in later life.
authors.affiliation: Department of Medicine, Cooper Hospital/University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey 08103.
authors.forename: J R
authors.initials: JR
authors.lastname: Kostman
authors.forename: B L
authors.initials: BL
authors.lastname: Sherry
authors.forename: C L
authors.initials: CL
authors.lastname: Fligner
authors.forename: S
authors.initials: S
authors.lastname: Egaas
authors.forename: P
authors.initials: P
authors.lastname: Sheeran
authors.forename: L
authors.initials: L
authors.lastname: Baken
authors.forename: J E
authors.initials: JE
authors.lastname: Bauwens
authors.forename: C
authors.initials: C
authors.lastname: Clausen
authors.forename: D M
authors.initials: DM
authors.lastname: Sherer
authors.forename: J J
authors.initials: JJ
authors.lastname: Plorde
mesh_terms: D000293:Adolescent; D000328:Adult; D016470:Bacteremia / Q000453:epidemiology*; D002648:Child; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000401:mortality; D006193:Haemophilus influenzae; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014861:Washington / Q000453:epidemiology