title: Sequence correction and reassignment of the TaqI polymorphic site in the human inter-gamma-globin gene region, an African-specific marker.
abstract: We report here that the assignment of nt 37504 in the human inter-gamma-globin gene region of the HUMHBB locus sequence as a C is incorrect and should be replaced by a T. Accordingly, the polymorphic TaqI site, originally described at position 37503 as an African-specific marker, is actually located at position 37992. A PCR-based assay for this anthropologically important genetic marker is described.
authors.affiliation: Laboratoire de Biochimie Génétique, Hôpital Robert Debré, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Guidal
authors.forename: C
authors.initials: C
authors.lastname: Lapouméroulie
authors.forename: R
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: J
authors.initials: J
authors.lastname: Elion
mesh_terms: D044383:Black People / Q000235:genetics*; D002874:Chromosome Mapping; D015342:DNA Probes / Q000032:analysis*; D005784:Gene Amplification; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D005810:Multigene Family / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites
chemical_list: D015342:DNA Probes; D005819:Genetic Markers