Correlation of clinical response (PANSS) and plasma levels of haloperidol and reduced haloperidol in schizophrenia.
1. The authors attempted to correlate plasma concentrations in H/rH and clinical efficacy from 8 schizophrenic patients (DSM IIIR) on H. 2. No significant correlations were found between H, rH plasma levels and positive and negative subscale for each patient. 3. The authors observed an opposite evolution concerning the mean results between plasma concentrations and PANSS total score.
Leroux
J M
JM
Faculté de Pharmacie, Lille, France.
Elia
E
E
Jacquet
M
M
Pommery
J
J
Levron
J C
JC
Bouhours
P
P
Erb
F
F
Sechter
D
D
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006220:Haloperidol / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013056:Spectrophotometry, Ultraviolet
C040692:4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol; D006220:Haloperidol