Studies on the mechanisms of glucocorticoid hypertension in humans.
Hypertension is a common feature of both Cushing's syndrome, which is relatively rare, and iatrogenic steroid administration, which is much more common. Cardiovascular mortality and morbidity are very significant in patients with both naturally occurring and iatrogenic disease. The mechanism of glucocorticoid induced hypertension in man remains undefined. Contrary to previous notions, it does not reflect urinary sodium retention or volume expansion. Increased pressor responsiveness may be an important contributor to the rise in blood pressure.
Whitworth
J A
JA
Department of Medicine, St. George Hospital, University of New South Wales, Kogarah, Australia.
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000503:physiopathology; D005938:Glucocorticoids / Q000378:metabolism / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006728:Hormones / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D006946:Hyperinsulinism / Q000139:chemically induced / Q000150:complications; D006973:Hypertension / Q000139:chemically induced* / Q000209:etiology; D010953:Plasma Volume; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013564:Sympathetic Nervous System / Q000503:physiopathology
D005938:Glucocorticoids; D006728:Hormones; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D006854:Hydrocortisone