title: Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury.
abstract: Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment. Such seizures are more likely in the elderly, in the presence of pre-existing neurological disease, and when theophylline is given with certain antibiotics and cimetidine. The mechanism of neuronal injury may be by the excessive release of endogenous excitotoxic glutamate.
authors.affiliation: Department of Neurology, St Vincent's Hospital, Dublin, Ireland.
authors.forename: J I
authors.initials: JI
authors.lastname: O'Riordan
authors.forename: J
authors.initials: J
authors.lastname: Hutchinson
authors.forename: M X
authors.initials: MX
authors.lastname: FitzGerald
authors.forename: M
authors.initials: M
authors.lastname: Hutchinson
mesh_terms: D000293:Adolescent; D000368:Aged; D000647:Amnesia / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012640:Seizures / Q000139:chemically induced* / Q000523:psychology; D013577:Syndrome; D013806:Theophylline / Q000009:adverse effects*
chemical_list: D013806:Theophylline