Magnetic resonance imaging in children receiving quinolones: no evidence of quinolone-induced arthropathy. A multicenter survey.
Twenty-nine children with cystic fibrosis (CF) were investigated for quinolone-induced arthropathy. Magnetic resonance imaging (MRI) was performed in 14/14 children treated with ofloxacin or ciprofloxacin and in 10/15 of those never treated with quinolones. The frequency of pathologic MRI findings, concerning cartilage thickness, careful analysis of the cartilage structure, presence of edema, cartilage-bone borderline and the presence of fluid in joints did not show any difference between both groups. Thus the presence of quinolone-induced arthrotoxicity cannot be confirmed in this study.
Danisovicová
A
A
Department of Pediatric Nursing, Postgraduate Medical School, Bratislava, Slovak Republic.
Brezina
M
M
Belan
S
S
Kayserová
H
H
Kaiserová
E
E
Hruskovic
I
I
Orosová
K
K
Dluholucký
S
S
Galova
K
K
Mathéova
E
E
D000293:Adolescent; D002358:Cartilage, Articular / Q000473:pathology; D002648:Child; D002939:Ciprofloxacin / Q000009:adverse effects*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000139:chemically induced*; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D015242:Ofloxacin / Q000009:adverse effects*
D002939:Ciprofloxacin; D015242:Ofloxacin