Aeroallergen sensitization can occur during fetal life.
Umbilical cord blood lymphocytes showed consistent proliferation in response to Dermatophagoides group I (Der p I) and occasionally even to Lolium group I (Lol p I) allergen. These data suggest sensitization in utero of T cells due to inhalation of these allergens by the mother during pregnancy.
Piccinni
M P
MP
Division of Clinical Immunology and Allergy, University of Florence, Italy.
Mecacci
F
F
Sampognaro
S
S
Manetti
R
R
Parronchi
P
P
Maggi
E
E
Romagnani
S
S
D000336:Aerosols; D000485:Allergens; D039741:Antigens, Dermatophagoides; D052179:Antigens, Plant; D005312:Fetal Blood; D006023:Glycoproteins / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000196:embryology*; D007156:Immunologic Memory; D007231:Infant, Newborn; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010940:Plant Proteins / Q000008:administration & dosage* / Q000276:immunology
D000336:Aerosols; D000485:Allergens; D039741:Antigens, Dermatophagoides; D052179:Antigens, Plant; D006023:Glycoproteins; C042814:Lol p I protein, Lolium perenne; D010940:Plant Proteins