title: Increased pulmonary perfusion worsens ventilation-perfusion matching.
abstract: BACKGROUND
  Severe exercise and administration of vasopressors may adversely affect pulmonary gas exchange in humans. The role of increases in pulmonary perfusion in worsening ventilation-perfusion (VA/Q) relationships is unclear, however, because concomitant changes in ventilation and alveolar gas composition occur. The purpose of this study was to determine whether increasing of lobar blood flow increased VA/Q heterogeneity in the absence of changes in respiratory parameters.
  
  
  METHODS
  Six pentobarbital-anesthetized dogs underwent bilateral thoracotomies, left upper lobectomy, and placement of an electromagnetic flow probe on the left lower lobe (LLL) pulmonary artery, and catheters were inserted into the LLL pulmonary artery distal to the flow probe and confluent trunk of the LLL pulmonary vein. A bronchial divider was inserted to allow separate ventilation of the right lung and LLL. Blood flow to the LLL (QLLL) was increased in random order to two and three times baseline blood flow by opening an arteriovenous fistula and partially occluding the right pulmonary artery. Minute ventilation and alveolar PCO2 of the lobe were unchanged due to use of constant tidal volume and respiratory rate and inspiration of variable amounts of carbon dioxide. VA/Q distributions of the LLL were obtained using the multiple inert gas elimination technique. The tracer inert gas arterial-alveolar difference ([a-A]D) area was used to assess VA/Q mismatch.
  
  
  RESULTS
  Increasing QLLL increased mean pulmonary artery pressure in the LLL (LLL Ppa). The PO2 of the LLL pulmonary venous blood remained unchanged, as the mixed venous oxygen tension (PvO2) was markedly increased. VA/Q inequality was increased, indicated by a 40% increase in the [a-A]D area when QLLL was increased to two times greater than baseline QLLL and a 58% increase in the [a-A]D area with three times greater than baseline QLLL. The [a-A]D area was highly correlated with the lobar blood flow (r = 0.97) and LLL Ppa (r = 0.97).
  
  
  CONCLUSIONS
  Marked increases in lobar blood flow and Ppa worsened pulmonary gas exchange. The degree of impairment was correlated with the degree of increase in lobar perfusion. However, increased lobar perfusion did not affect LLL pulmonary venous blood oxygenation because the decrease in PO2, due to increased VA/Q mismatch, was opposed by an increase in PO2, due to increased PvO2.
authors.affiliation: University of Washington, School of Medicine, Seattle.
authors.forename: K B
authors.initials: KB
authors.lastname: Domino
authors.forename: B L
authors.initials: BL
authors.lastname: Eisenstein
authors.forename: T
authors.initials: T
authors.lastname: Tran
authors.forename: M P
authors.initials: MP
authors.lastname: Hlastala
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood / Q000502:physiology; D004285:Dogs; D005260:Female; D008168:Lung / Q000098:blood supply* / Q000502:physiology; D008297:Male; D010313:Partial Pressure; D010477:Perfusion; D011650:Pulmonary Alveoli / Q000098:blood supply / Q000502:physiology; D012119:Respiration / Q000502:physiology*; D014692:Ventilation-Perfusion Ratio
chemical_list: D002245:Carbon Dioxide