Appearance of different diabetic symptoms after streptozocin administration: a comparison study.
The purpose of the present study was to compare the time required to develop each of the following diabetic symptoms after the streptozocin administration (60 mg/kg, iv) in rats: hyperglycaemia, glycosuria, polyuria, polydipsia, polyphagia, and body weight reduction. The data showed that hyperglycaemia, glycosuria, polyuria and polydipsia were significantly increased in 24 hours after the streptozocin administration; however, there was a delay of 3 days before a significant reduction of body weight was detected, and the food intake was not significantly increased until 7 days after the streptozocin administration.
Wong
K K
KK
Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China.
Tzeng
E S
ES
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D004326:Drinking; D005247:Feeding Behavior; D006029:Glycosuria; D006943:Hyperglycemia; D008297:Male; D011141:Polyuria; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D013894:Thirst; D013997:Time Factors
D001786:Blood Glucose; D013311:Streptozocin