[An experimental study of sulprostone as an agent in preparation for abortion].
The prostaglandin E sulprostone was studied in experiments on pregnant rats. It was shown to stimulate the bioelectrical activity of the uterus, by increasing the amplitude and frequency of biological potentials. Sulprostone was found to have abortive and embryotoxic effects which were especially pronounced during placentation. The drug induced a slight teratogenic effect.
Korkhov
V V
VV
Mats
M N
MN
Boĭkova
V V
VV
Zaĭtseva
M A
MA
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D000028:Abortion, Induced / Q000379:methods*; D000818:Animals; D015232:Dinoprostone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D051379:Mice; D010929:Placentation / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D000020:Abortifacient Agents, Nonsteroidal; C016767:sulprostone; D015232:Dinoprostone
Eksperimental'noe issledovanie sul'prostona kak sredstva podgotovki k abortu.