Healing characteristics of a type I collagenous structure treated with corticosteroids.
One hundred twenty-eight skeletally mature New Zealand White rabbits were used to study the effect of a single corticosteroid injection on the biomechanical, biochemical, and histologic aspects of ligamentous healing. Two steroid dosages were used. The amount of the low-dose steroid was calculated by determining the corticosteroid concentration at which fibroblastic synthesis of collagen was inhibited in vitro. A human equivalent dose of betamethasone was used as the high-dose steroid injection. These two steroid doses and a saline control were injected around a transected medial collateral ligament. At 10 days all groups showed significantly inferior biomechanical properties relative to noninjected controls. By 3 weeks the human equivalent steroid dose group continued to demonstrate significantly inferior properties. Histologic and biochemical analyses confirmed the biomechanical results. The clinical relevance of the study was that the delivery of a human equivalent steroid dose into an acutely injured ligament significantly impairs the healing process relative to a noninjected ligament at 10 days and at 3 weeks after injury. This implies that a corticosteroid-treated injured ligament may not be able to withstand the mechanical loads of early vigorous rehabilitation.
Wiggins
M E
ME
Department of Orthopaedics, Brown University School of Medicine, Rhode Island Hospital, Providence 02903.
Fadale
P D
PD
Barrach
H
H
Ehrlich
M G
MG
Walsh
W R
WR
D000818:Animals; D001623:Betamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D017888:Medial Collateral Ligament, Knee / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D001623:Betamethasone