[Development of the reproductive system in the progeny of rats with streptozotocin diabetes].
Specificities of functioning and development of the reproductive system and mechanism of its regulation with hypothalamic structures were studied in the progeny of rats with streptozotocin diabetes. For this purpose pituitary sensitivity was analyzed in mature animals, as was functional capacity of the feedback system mediating the hypothalamic regulation of gonadotropin secretion in rat males and females at the age when this system normally starts functioning in health. The hypothalamo-hypophyseo-gonadal system feedback mechanism was found to develop in the progeny of female rats with streptozotocin diabetes later than in health. Pituitary sensitivity to LH-RH was reduced and LH level reduced by 1.5 times in mature progeny of rats with streptozotocin diabetes as compared to that in the progeny of healthy rats. These results permit a conclusion that the progeny of rats with streptozotocin diabetes develop disorders in the mechanism regulating the reproductive system of the body, though not so grave as to make this system functioning impossible.
Babichev
V N
VN
Shishkina
I V
IV
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005246:Feedback; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006066:Gonads / Q000503:physiopathology; D007031:Hypothalamus / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D012098:Reproduction / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
Stanovlenie reproduktivnoĭ sistemy u potomstva krys, bol'nykh streptozototsinovym diabetom.