[Pro-oxidant and antioxidant homeostasis in guinea pigs following fractionated x-ray irradiation at low doses and the correction of disorders with an antioxidant complex].
The state of pro-oxidant-antioxidant homeostasis in guinea pigs exposed to whole-body fractionated X irradiation (5 fractions of 0.2 Gy at a 24 hr interval, up to total dose of 1.0 Gy, at a dose rate of 0.425 R/min) and a possibility of its disturbance correction with the complex of vitamins C, E and P was studied. Accumulation of primary and secondary lipid peroxidation products, decrease of the ascorbic acid content, increase of the content of its oxidized forms (dehydroascorbic acid and diketogulonic acid) in radiosensitive (spleen and small intestine) and radioresistant organs were found. Antioxidant complex administration reduced the disturbances of pro-oxidant-antioxidant homeostasis, but did not provide complete normalization.
Baraboĭ
V A
VA
Oleĭnik
S A
SA
Blium
I A
IA
Khmelevskiĭ
Iu V
IuV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000528:radiation effects* / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000378:metabolism / Q000528:radiation effects / Q000627:therapeutic use*; D002392:Catechin / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D004338:Drug Combinations; D006168:Guinea Pigs; D006706:Homeostasis / Q000528:radiation effects*; D015227:Lipid Peroxidation / Q000528:radiation effects; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000528:radiation effects*; D013662:Tea; D013997:Time Factors; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014916:Whole-Body Irradiation; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D004338:Drug Combinations; D017382:Reactive Oxygen Species; D013662:Tea; D014810:Vitamin E; D002392:Catechin; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D024505:Tocopherols
Prooksidantno-antioksidantnyĭ gomeostaz u morskikh svinok posle fraktsionirovannogo rentgenovskogo oblucheniia v malykh dozakh i korrektsiia ego narusheniĭ antioksidantnym kompleksom.