Toxic effects of systemic retinoids on meibomian glands.
Systemic use of retinoids is common in the treatment of various dermatological disorders. Blepharitis and conjunctivitis have been reported in 20-45% of the patients following systemic treatment with 13-cis-retinoic acid. Our purpose was to study the histopathological changes in the eyelids caused by long-term systemic treatment of female New Zealand rabbits with isotretinoin (2 mg/kg) and etretinate (2 mg/kg). The histopathological evaluation showed degenerative changes in the meibomian gland acini, leading to cell necrosis and a decrease in the basaloid cells lining the acini walls. No evidence of acute or chronic inflammatory reaction was noted.
Kremer
I
I
Department of Ophthalmology, Beilinson Medical Center, Petah Tiqva, Israel.
Gaton
D D
DD
David
M
M
Gaton
E
E
Shapiro
A
A
D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D005050:Etretinate / Q000008:administration & dosage / Q000633:toxicity*; D005143:Eyelids / Q000473:pathology; D005260:Female; D015474:Isotretinoin / Q000008:administration & dosage / Q000633:toxicity*; D008537:Meibomian Glands / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D011817:Rabbits
D002214:Capsules; D005050:Etretinate; D015474:Isotretinoin