[Nucleoside diphosphate kinase/Nm23 and metastatic potency].
The nm23-H1 gene encoding the nucleoside diphosphate (NDP) kinase A has been proposed as a tumor metastasis suppressor. Two important features emerge from published data: 1) an inverse correlation between the metastatic invasion and the level of NDP kinase/Nm23 was observed in melanomas, hepatocellular carcinomas and, in some studies, on breast carcinomas; 2) an overexpression of NDP kinase/Nm23 was observed in several solid tumors as compared to normal surrounding tissues, positively correlated with aggressiveness in the case of neuroblastomas. The level of NDP kinase/Nm23 in tumors appears to be altered in different ways, related or not to the metastatic potential, depending on the tissue of origin. Its evaluation as a prognostic or diagnostic marker of tumor invasion and aggressiveness deserves further study.
Lacombe
M L
ML
INSERM U181, faculté de médecine Saint-Antoine, Paris, France.
D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D009701:Nucleoside-Diphosphate Kinase / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
D009701:Nucleoside-Diphosphate Kinase
Nucléoside diphosphate kinase/Nm23 et potentiel métastatique.