[Clinical effects of granisetron and methylprednisolone against nausea, vomiting and anorexia induced by cisplatin].
We investigated the usefulness of concurrent therapy of granisetron with methylprednisolone sodium for on nausea, vomiting and anorexia induced by chemotherapy, including cisplatin, in patients with oral cancer. Group A: 10 patients who were on concurrent therapy of granisetron (3.0 mg/body) with methylprednisolone sodium (750 mg/body) (19 courses). Group B: 13 patients who were given coktail therapy of methylprednisolone sodium (750 mg/body) as the base drug plus metoclopramide (46.7 mg/body on average) and domperidone (82.9 mg/body on average) (21 courses). Efficacy rates for nausea, vomiting and anorexia were 89.4%, 100% and 100% in group A, and 33.3%, 47.6% and 42.9% in group B, respectively. Statistical significance was found with nausea, vomiting and anorexia (p < 0.01). The results suggest usefulness of concurrent therapy of granisetron with methylpredonisolone sodium for cisplatin-induced nausea, vomiting and anorexia.
Kawashima
T
T
Dept. of Dentistry and Oral Surgery, Wakayama Medical College.
Wada
T
T
Morita
N
N
Ohmata
T
T
Miyata
K
K
Sakamoto
T
T
D000328:Adult; D000368:Aged; D000855:Anorexia / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects*; D004294:Domperidone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D017829:Granisetron / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008787:Metoclopramide / Q000008:administration & dosage; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy; D009325:Nausea / Q000188:drug therapy*; D014839:Vomiting / Q000188:drug therapy*
D002945:Cisplatin; D004294:Domperidone; D017829:Granisetron; D008775:Methylprednisolone; D008787:Metoclopramide