CSF neuron-specific enolase after methohexital activation during electrocorticography.
We report changes in CSF and serum neuron-specific enolase (NSE) before and after methohexital infusion during electrocorticography in three patients undergoing epilepsy surgery. NSE is a critical enzyme for energy metabolism that accounts for 1.5% of all soluble brain protein and is an accepted marker of neuronal injury. CSF NSE rose three- to fourfold from baseline within 60 minutes after methohexital activation. Serum NSE was unchanged. This report supports evidence that CSF NSE rises acutely after induction of epileptiform activity and suggests that CSF NSE is a marker of seizure activity.
Rabinowicz
A L
AL
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
Correale
J D
JD
Couldwell
W T
WT
DeGiorgio
C M
CM
D015415:Biomarkers; D002540:Cerebral Cortex / Q000503:physiopathology; D006801:Humans; D008723:Methohexital; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D012640:Seizures / Q000134:cerebrospinal fluid* / Q000139:chemically induced / Q000503:physiopathology
D015415:Biomarkers; D008723:Methohexital; D010751:Phosphopyruvate Hydratase