title: Early steps in fusion between Epstein-Barr virus and a human hepatoma cell line (Li7A).
abstract: Epstein-Barr virus, the causative agent of mononucleosis and several human cancers, infects cells via complement receptor type 2 (CR2). Expression of this receptor is restricted to B lymphocytes, some epithelial cells and immature thymocytes; expression of CR2-like proteins has been also found on T cells. In the present report, we identified the presence, on the membrane of Li7A cells, of a novel EBV receptor distinct from CR2 capable of triggering fusion with EBV virions with more rapid kinetics than that found with lymphoblastoid cells (Raji).
authors.affiliation: Instituto di Medicina Sperimentale, CNR, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lisi
authors.forename: D
authors.initials: D
authors.lastname: Pozzi
authors.forename: S
authors.initials: S
authors.lastname: Iacovacci
authors.forename: G
authors.initials: G
authors.lastname: Carloni
authors.forename: G
authors.initials: G
authors.lastname: Lanzilli
authors.forename: I
authors.initials: I
authors.lastname: De Ros
authors.forename: G
authors.initials: G
authors.lastname: Ravagnan
authors.forename: S
authors.initials: S
authors.lastname: Grimaldi
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000382:microbiology*; D002462:Cell Membrane / Q000378:metabolism; D015933:Complement C3d / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000382:microbiology; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D006801:Humans; D007700:Kinetics; D008113:Liver Neoplasms / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology; D008561:Membrane Fusion / Q000187:drug effects; D011951:Receptors, Complement / Q000032:analysis; D017464:Receptors, Complement 3d; D011991:Receptors, Virus / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D011951:Receptors, Complement; D017464:Receptors, Complement 3d; D011991:Receptors, Virus; D015933:Complement C3d