[Clinical evaluation of aiconol side effects].
In the study of 164 patients with atherogenic dyslipidemia the authors studied side effects of aiconol, concentrated cod liver oil. Its lipid component contains not less than 18% of omega-3 polyunsaturated fatty acids (PUFA). All the patients were divided into 4 groups: 51 subjects of group 1 received aiconol in the form of oil, 35 subjects of group 2 had protein dietetic caviar prepared from animal proteins with addition of 3% aiconol, 38 subjects of group 3 were given protein-oil emulsion containing 20% aiconol and 40 patients of group 4 took gelatin aiconol in capsules. Side effects of the above food ingredients enriched with omega-3 PUFA were found to be of metabolic nature. These manifested most evidently in patients on oil aiconol incorporating both maximal doses of omega-3 PUFA and the largest amounts of inert constituents acting as additional fat load on the liver and pancreas. Group 1 patients also suffered from aggravated chronic gastrointestinal, hepatic and pancreatic disorders. Because of reduced quantities of omega-3 PUFA in the diets of group 2, 3 and 4 patients, they displayed much less severe side effects.
Vertkin
A L
AL
Martynov
I V
IV
Svetova
Iu B
IuB
Gaĭdukova
E V
EV
Bikbov
T M
TM
Martynov
A I
AI
D000328:Adult; D000368:Aged; D003060:Cod Liver Oil / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D004044:Dietary Proteins / Q000008:administration & dosage*; D004304:Dosage Forms; D015525:Fatty Acids, Omega-3 / Q000032:analysis; D001068:Feeding and Eating Disorders / Q000139:chemically induced* / Q000378:metabolism; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D004044:Dietary Proteins; D004304:Dosage Forms; D015525:Fatty Acids, Omega-3; D003060:Cod Liver Oil
Klinicheskaia otsenka pobochnykh éffektov preparata éĭkonol.