title: Characterization of the serum antibody response induced by Haemophilus influenzae type b tetanus protein-conjugate vaccine in infants receiving a DTP-combined vaccine from 2 months of age.
abstract: The serum antibody response induced by Haemophilus influenzae type b capsular polysaccharide (CPS)-tetanus protein conjugate vaccine combined to DTP vaccine was characterized in infants receiving three injections from 2 months of age. Sixty-five per cent and 94% of infants had anti-CPS antibody levels > or = 1 micrograms ml-1 after the second and third dose, respectively. The antibody response was mostly made up of IgG with a marked IgG1 predominance. Significant rises in bactericidal and in complement-mediated opsonic activities were observed after immunization. These data clearly show that this vaccine can be successfully administered in one syringe together with DTP vaccine during the regular infant immunization programme.
authors.affiliation: Laboratory of Immunology and Immunopathology, CNRS URA 1172, University Hospital, Poitiers, France.
authors.forename: A
authors.initials: A
authors.lastname: Barra
authors.forename: R
authors.initials: R
authors.lastname: Dagan
authors.forename: J L
authors.initials: JL
authors.lastname: Preud'homme
authors.forename: A
authors.initials: A
authors.lastname: Bajart
authors.forename: B
authors.initials: B
authors.lastname: Danve
authors.forename: B
authors.initials: B
authors.lastname: Fritzell
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007132:Immunoglobulin Isotypes / Q000097:blood; D007223:Infant; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C055753:Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate; D007132:Immunoglobulin Isotypes; D013745:Tetanus Toxoid