title: Treatment of Paget's disease of bone with single dose intravenous pamidronate.
abstract: OBJECTIVE
  To assess the efficacy of a single intravenous infusion of pamidronate in Paget's disease of bone.
  
  
  METHODS
  Fourteen patients with active Paget's disease (raised serum alkaline phosphatase, bone pain or neurological involvement) were treated with a single intravenous infusion of 105 mg pamidronate. Patients were assessed for biochemical and clinical improvement for up to two years following treatment. A further infusion was given following symptomatic relapse (pain at a known site of pagetic involvement).
  
  
  RESULTS
  Serum alkaline phosphatase fell following treatment, with a nadir 5.9 months after treatment. Bone pain was improved in nine of 12 patients after six months. Retreatment of four patients resulted in a similar response.
  
  
  CONCLUSIONS
  Single dose intravenous pamidronate (105 mg) is a convenient and effective treatment for Paget's disease.
authors.affiliation: Department of Rheumatology, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors.forename: R A
authors.initials: RA
authors.lastname: Watts
authors.forename: S J
authors.initials: SJ
authors.lastname: Skingle
authors.forename: M M
authors.initials: MM
authors.lastname: Bhambhani
authors.forename: G
authors.initials: G
authors.lastname: Pountain
authors.forename: A J
authors.initials: AJ
authors.lastname: Crisp
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D004164:Diphosphonates / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy* / Q000201:enzymology; D000077268:Pamidronate
chemical_list: D004164:Diphosphonates; D000469:Alkaline Phosphatase; D000077268:Pamidronate