[Studies on preparation technology of microspheres of contraceptives].
Contraceptive poly ethylglycol-lactide (PEGL), an artificial biodegradable polymer microsphere was prepared by a solvent evaporation process using levonorgestrel (LNG) and estradiol (E2) as model drugs and PEGL as the core material. The experimental conditions were optimized, the mean volume diameter obtained being 30 microns and rate of encapsulation 75-82%. In vitro, it was found that the drug release rate decreased with decreasing drug content in the microspheres. The microspheres of the contraceptive maintained anticonception duration in mice for over 6 months, indicating that the microspheres have remarkably long acting sustained release action.
Lei
Y
Y
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Lu
B
B
D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D016912:Levonorgestrel / Q000008:administration & dosage*; D051379:Mice; D008863:Microspheres; D011091:Polyesters; D011092:Polyethylene Glycols; D013678:Technology, Pharmaceutical
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011092:Polyethylene Glycols; D004958:Estradiol; D016912:Levonorgestrel; C083464:poly(ethyleneglycol-lactide)