title: Postural vascular response in human skin: passive and active reactions to alteration of transmural pressure.
abstract: Laser-Doppler (LD) fluxmetry was performed in the palmar finger skin of healthy subjects to study the mechanisms contributing to the postural vascular response. Local transmural pressure in the skin blood vessels of the region studied was altered for 1 min in two experimental series either by passive movement of the arm to different vertical hand positions relative to heart level or by application of external pressure (-120-180 mmHg) to the finger. Heart and respiratory rate, arterial blood pressure, and LD flux in the contralateral finger (kept at heart level) were measured. The measurements suggest a compound reaction of local (myogenic) and systemic (neurogenic) mechanisms: the local regulatory component appears as a graded active vascular response elicited by passive vessel distension or compression. A systemic component, associated with a single deep inspiration, is frequently observed during the actual movement of the arm. In addition, prolonged holding of the test hand in a given vertical position also elicits a delayed vascular response in the control hand at heart level, which may be generated by volume receptors in the intrathoracic low-pressure system.
authors.affiliation: Department of Physiology, Freie Universität Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Jepsen
authors.forename: P
authors.initials: P
authors.lastname: Gaehtgens
mesh_terms: D000328:Adult; D001808:Blood Vessels / Q000502:physiology; D005260:Female; D006225:Hand / Q000502:physiology; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D011187:Posture; D011312:Pressure; D012867:Skin / Q000098:blood supply*