title: Dissociation, childhood trauma, and the response to fluoxetine in bulimic patients.
abstract: Histories of childhood trauma have been reported previously in bulimic subjects but no study to date has assessed how these experiences may affect response to fluoxetine. Thirty outpatient subjects in a placebo-controlled trial of 60 mg of fluoxetine for the treatment of bulimia nervosa completed the Dissociative Experiences Scale and a self-report instrument assessing trauma. Response to treatment was measured with the Hamilton Depression Scale-17 (HAMD-17), the CGI, the PGI, and the change in number of binges per day. Subjects taking fluoxetine with histories of physical abuse showed a significantly greater drop in HAMD-17 scores than those without such histories. No relationship between a reported history of abuse and the response of binging to fluoxetine was found. A history of abuse does not appear to predict the response of binging to fluoxetine but may predict a greater response of nonspecific symptoms like depression.
authors.affiliation: Harvard Medical School, Boston, MA.
authors.forename: M K
authors.initials: MK
authors.lastname: McCarthy
authors.forename: D C
authors.initials: DC
authors.lastname: Goff
authors.forename: L
authors.initials: L
authors.lastname: Baer
authors.forename: J
authors.initials: J
authors.lastname: Cioffi
authors.forename: D B
authors.initials: DB
authors.lastname: Herzog
mesh_terms: D000293:Adolescent; D000328:Adult; D002032:Bulimia / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D002650:Child Abuse, Sexual / Q000150:complications / Q000523:psychology; D002675:Child, Preschool; D004213:Dissociative Disorders / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010553:Personality Development; D010555:Personality Inventory
chemical_list: D005473:Fluoxetine