Serious childhood angiomas: unsuccessful alpha-2b interferon treatment. A report of four cases.
Over a 4-year period, we managed four children with alarming haemangiomas (two cases of Kasabach-Merritt syndrome and two life-threatening haemangiomas). Systemic steroid therapy was ineffective. Other treatments (radiotherapy, anti-platelet drugs) were also ineffective in the Kasabach-Merritt patients. On the basis of recent reports on the effects of interferon on endothelial cells, we used alpha-2 interferon therapy, but obtained no response.
Teillac-Hamel
D
D
Service de Dermatologie, Hôpital Necker-Enfants Malades, Paris, France.
De Prost
Y
Y
Bodemer
C
C
Andry
P
P
Enjolras
O
O
Sebag
G
G
Brunelle
F
F
Hubert
P
P
Nihoul-Fekete
C
C
D001132:Arm; D002081:Buttocks; D002675:Child, Preschool; D005145:Face; D005260:Female; D006391:Hemangioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D017211:Treatment Failure
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins