Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests.
This paper presents a 7 year old girl with cough variant asthma, in which house dust challenge test provoked fine crackles on auscultation without any changes of lung function test. Pretreatment with DL-chlorpheniramine maleate for 7 days inhibited the appearance of fine crackles. On histamine inhalation test, fine crackles and rhonchi appeared on auscultation without bronchoconstriction (% fall of one-second forced expiratory volume < 10%). These data suggest that the cause of cough variant asthma is mainly an immunoglobulin E-mediated allergic reaction in the mucus secreting system.
Morikawa
A
A
Department of Pediatrics, Gunma University School of Medicine, Japan.
Mitsuhashi
M
M
Tabata
H
H
Seki
Y
Y
Mochizuki
H
H
Tokuyama
K
K
Kuroume
T
T
D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002648:Child; D003371:Cough / Q000503:physiopathology*; D004391:Dust; D005260:Female; D006632:Histamine; D006801:Humans; D016210:Methacholine Chloride
D004391:Dust; D016210:Methacholine Chloride; D006632:Histamine