Cytokines and their role in the pathogenesis of severe food hypersensitivity reactions.
Cytokines are proteins produced by one cell that are capable of altering the behavior of another cell. Their biologic effects are both pleomorphic and redundant. A number of cytokines have been implicated in the genesis of allergic reactions, including IL-4, IL-5, IL-6, and tumor necrosis factor (TNF). In contrast, other cytokines such as gamma interferon (gamma-IFN) may have biologic actions that act to limit allergic responses. In studies on patients with severe food allergy, we have found cytokine production from peripheral T cells to be abnormal following mitogenic stimulation. These lymphokine abnormalities may contribute to the elevation in IgE and the eosinophilia seen in severe food allergy.
Jaffe
J S
JS
Head, Mast Cell Physiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Metcalfe
D D
DD
D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D005512:Food Hypersensitivity / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
D016207:Cytokines