title: The significance and prevention of air emboli with the total artificial heart.
abstract: Embolism remains a significant complication of the total artificial heart (TAH). The ineffectual deairing of the TAH can allow embolization of the retained air. The standard needle aspiration of TAH air (Group A) was compared with a new protocol (Group B) that included standard needle TAH aspiration plus simultaneous pumping of the TAH against an occluded ascending aorta and main pulmonary artery with vacuum applied to a needle in the proximal aorta and pulmonary artery. There were 4 calves in each group. There was no premortem evidence of systemic or pulmonary emboli. Both groups of animals were electively terminated less than 2 weeks postoperatively Postoperative mean aortic and pulmonary artery pressures were recorded for each animal. Animals in Group B had a significant decline in pulmonary artery pressures (43 +/- 12 vs. 33 +/- 8 mm Hg) 1 h after TAH implantation when compared with Group A. All other aortic and pulmonary artery pressure differences between Groups A and B were not statistically significant within 24 h of the operation. Group A animals had a 75% incidence, and Group B animals had 100% incidence of TAH thrombus. This very small thrombus was found exclusively at the inflow valve-TAH housing interface. Evaluation of the kidneys postmortem was used to identify embolic injury. All animals in Group A had evidence of acute, hemorrhagic injury, but none of the Group B animals had similar injury. Half of the animals in each group had small, fibrotic chronic renal cortical injury, which did not develop during TAH implantation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Ohio State University Hospitals, Division of Thoracic and Cardiovascular Surgery, Columbus 43210.
authors.forename: K D
authors.initials: KD
authors.lastname: Murray
authors.forename: P F
authors.initials: PF
authors.lastname: Binkley
authors.forename: D A
authors.initials: DA
authors.lastname: Dumond
authors.forename: K M
authors.initials: KM
authors.lastname: Watson
authors.forename: E P
authors.initials: EP
authors.lastname: Howanitz
authors.forename: P
authors.initials: P
authors.lastname: Ross
authors.forename: P D
authors.initials: PD
authors.lastname: Myerowitz
mesh_terms: D000818:Animals; D002417:Cattle; D004618:Embolism, Air / Q000209:etiology* / Q000517:prevention & control*; D006354:Heart, Artificial / Q000009:adverse effects*; D007238:Infarction / Q000209:etiology; D007668:Kidney / Q000098:blood supply; D008722:Methods; D013927:Thrombosis / Q000209:etiology