Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats.
The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically.
Cannon
G W
GW
Veterans Affairs Medical Center, Salt Lake City, Utah 84148.
McCall
S
S
Cole
B C
BC
Radov
L A
LA
Ward
J R
JR
Griffiths
M M
MM
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D001323:Autoantibodies / Q000032:analysis; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D011897:Random Allocation; D051381:Rats
D001323:Autoantibodies; D006052:Gold Sodium Thiomalate; D016572:Cyclosporine; D003520:Cyclophosphamide; D003094:Collagen