title: Possible relation between the U54 segment of the CTHV genome and the conserved gene block C rearranged in alpha and gamma herpesvirus genomes.
abstract: The genome of CTHV is an atypical member of the gamma-2 subgroup of herpesvirus genomes that contains two segments (instead of one) of DNA with low G+C content flanked by highly repetitious DNA with high G+C content. The segments freely undergo polarity inversion with respect to one another. We have found nucleotide sequences in one of these segments, the U54 segment, whose putative translational products show clear similarity to two ubiquitous herpesvirus gene products, a single-stranded DNA binding protein and a protein of the helicase superfamily. These sequences are located within 5 kilobase pairs of the ends of the segment, suggesting that U54 may be related to a genetically defined entity (gene block C; Davison and Taylor (1987) J. Gen Virol. 68, 36-48) issuing from a previous sequence comparison of the gamma-1 genome of Epstein-Barr virus and the alpha genome of varicella-zoster virus.
authors.affiliation: Institute de Recherches Scientifiques sur le Cancer, Villejuif, France.
authors.forename: T
authors.initials: T
authors.lastname: Foulon
authors.forename: B
authors.initials: B
authors.lastname: Pertuiset
authors.forename: C
authors.initials: C
authors.lastname: Cajean-Feroldi
authors.forename: P
authors.initials: P
authors.lastname: Sheldrick
mesh_terms: D018138:Alphaherpesvirinae / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004265:DNA Helicases / Q000235:genetics*; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins / Q000235:genetics*; D018142:Gammaherpesvirinae / Q000235:genetics*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid
chemical_list: D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D004265:DNA Helicases