Effect of silica on the spontaneous cytotoxicity of axial organ cells from Asterias rubens.
Axial organ cells (A.O.) which are composed of phagocytes and lymphocytes from the sea star Asterias rubens exert a spontaneous cytotoxicity against mouse tumour cells. This toxicity was tested in the presence or absence of silica. It appears that phagocytes play the role of killer cells.
Leclerc
M
M
Department of Biology, University of Orleans, France.
Bajelan
M
M
Barot
R
R
Tlaskalova-Hogenova
H
H
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D012822:Silicon Dioxide / Q000494:pharmacology*; D013045:Species Specificity; D013215:Starfish / Q000187:drug effects / Q000276:immunology*
D007166:Immunosuppressive Agents; D012822:Silicon Dioxide