[The use of the multivariate estimation method for the objective evaluation of the effect of antihypoxic therapy in the first 24 hours after an absolutely lethal radiation injury].
Three groups of rats (intact, irradiated with 30 Gy of gamma rays and treated after irradiation with the use of pharmacological and metabolic drugs protecting brain against hypoxia were studied. In 24 hours after the influence the animals have undergone the neurobehavioral testing and then were sacrificed, a number of neurochemical parameters depicting energy metabolism and metabolic GABA bypath in brain were studied (general number of parameters were 24). Using classical method of t-statistics only enhancement of labelled GABA catabolism and deterioration of general behavioral activity were verified, the modifying effect of the pharmacological and metabolic protection against hypoxia was not found. Using methods of multidimensional evaluation the protective and sanogenic character of the used method of therapy was verified. Thus, using discrimination analysis (Mahalanobis criterion) high similarity of intact and treated groups of animals was estimated. It was confirmed using methods of coupled and multiple correlation and method of route coefficients. The statistical connections between neurochemical and neurobehavioral parameters were found which can be useful for understanding of the mechanisms of the early postradiation syndrome development.
Rozanov
V A
VA
Lobasiuk
B A
BA
Reĭtarova
T E
TE
Chernikov
G B
GB
Petrov
A P
AP
Kozozaeva
O O
OO
D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects; D001921:Brain / Q000378:metabolism / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D015999:Multivariate Analysis; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000528:radiation effects
D005680:gamma-Aminobutyric Acid
Primenenie metoda mnogomernogo otsenivaniia dlia ob''ektivizatsii vliianiia antigipoksicheskoĭ terapii v pervye sutki posle absoliutno letal'nogo luchevogo porazheniia.