GFAP-specific oligoclonal bands in the CSF of a patient with acute myelitis.
The specificity for GFAP (glial fibrillary acidic protein) of oligoclonal IgG bands in the CSF of a patient with acute myelitis was demonstrated by isoelectric focusing and affinity blotting. Findings were confirmed by western blotting using a monoclonal antibody to GFAP as a reference. Immune reactions to this astrocyte protein are considered as arising secondary to spinal cord tissue lesion.
Kaiser
R
R
Department of Neurology, University of Freiburg, Germany.
Lücking
C H
CH
D000208:Acute Disease; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000915:Antibody Affinity / Q000276:immunology; D001253:Astrocytes / Q000276:immunology; D015153:Blotting, Western; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005073:Evoked Potentials, Somatosensory; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid* / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000134:cerebrospinal fluid / Q000276:immunology; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D009187:Myelitis / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D013116:Spinal Cord / Q000503:physiopathology; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D013979:Tibial Nerve
D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein; D007070:Immunoglobulin A; D007074:Immunoglobulin G