Etiology of venous ulceration.
The etiology of venous ulceration is far more complex than Homans' theory of stagnation and hypo-oxygenation. Indeed, studies have shown that flow in lipodermatosclerotic limbs is actually faster than normal. We suggest, therefore, that the terms "stasis dermatitis" and "stasis ulcer" be dropped from medical parlance. The term "lipodermatosclerosis with ulceration" as used by the British, or simply "venous ulcer," would seem more appropriate. Venous hypertension, produced by incompetence of deep and communicating vein valves and thrombosis of segments of the deep system, is closely correlated with the development of venous ulcers. Precisely how this venous hypertension translates into ulceration is unclear. Burnand et al showed that fibrin cuffs are deposited around the capillaries in lipodermatosclerotic limbs. These cuffs may serve as barriers to the diffusion of oxygen, leading to local ischemia and epidermal necrosis. Others suggest that trapped leukocytes in the microcirculation alter capillary permeability by releasing various inflammatory mediators that hasten the flow of fibrinogen across the capillary membrane and promote the formation of fibrin cuffs. Proof of this hypothesis is still lacking, but may eventually come from using radioactive WBC tagging procedures. A synthesis of these two theories may in fact explain the etiology of venous ulceration.
Gourdin
F W
FW
Department of Dermatology, Medical College of Georgia, Augusta 30912-2900.
Smith
J G
JG
D002199:Capillary Permeability; D015687:Cell Hypoxia; D002908:Chronic Disease; D005337:Fibrin / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007962:Leukocytes; D008833:Microcirculation; D009336:Necrosis; D009626:Terminology as Topic; D013927:Thrombosis / Q000150:complications; D014689:Venous Insufficiency / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D014690:Venous Pressure
D005337:Fibrin; D005340:Fibrinogen