title: The evolution of postoperative ileus after laparoscopic cholecystectomy. A comparative study with conventional cholecystectomy and sympathetic blockade treatment.
abstract: Our study is prompted by the arrival of laparoscopic cholecystectomy in connection with the evolution of postoperative ileus (PI) and by its avoidance of the intraabdominal handling implied in conventional cholecystectomy. With this aim a prospective, controlled, randomized, and blind clinical trial was designed using 100 patients divided into five groups (n = 20): I, conventional cholecystectomy (CC): II, CC+injection of 20 ml bupivacaine 0.5% into the mesentery root; III, CC + 7.5 mg propranolol i.v. and 0.5 mg neostigmine s.c., postoperatively until the first defecation; IV, II+III; and V, laparoscopic cholecystectomy. The shortest period of PI was observed in group V. This period increases notably in group IV (53 h), group II (72 h), and group III (84 h) relative to the control group with (89 h). This reduction in PI time runs parallel with an improvement in the patient's general state of well-being. We concluded that after laparoscopic cholecystectomy PI is nonexistent. Furthermore, this study confirms the correlation between the avoidance of intraabdominal manipulation and the evolution of postoperative ileus.
authors.affiliation: I Department of Surgery, University of Málaga, Spain.
authors.forename: M
authors.initials: M
authors.lastname: García-Caballero
authors.forename: C
authors.initials: C
authors.lastname: Vara-Thorbeck
mesh_terms: D001340:Autonomic Nerve Block; D002045:Bupivacaine; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D006801:Humans; D007415:Intestinal Obstruction / Q000453:epidemiology / Q000517:prevention & control*; D008875:Middle Aged; D009388:Neostigmine / Q000627:therapeutic use; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011433:Propranolol / Q000627:therapeutic use; D011446:Prospective Studies
chemical_list: D009388:Neostigmine; D011433:Propranolol; D002045:Bupivacaine