title: Strategies for pH gradients' optimization.
abstract: A few problems arising when optimizing the composition of the mixtures to be used for IPG casting with a two chambers mixer are discussed. The behavior in the composition space of a number of objective functions is described by simulation. This allows the formalization of rules to be followed for finding the initial guess required to start the optimization algorithm and for directing and limiting the search of the objective's minimum. the results of the simulation show that a fully automatic gradient computation and optimization is possible.
authors.affiliation: Department of Biomathematics, UCLA School of Medicine 90024.
authors.forename: F C
authors.initials: FC
authors.lastname: Celentano
authors.forename: E
authors.initials: E
authors.lastname: Gianazza
mesh_terms: D000465:Algorithms; D002021:Buffers; D003198:Computer Simulation; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008956:Models, Chemical; D011522:Protons
chemical_list: D002021:Buffers; D011522:Protons