Evidence for the degradation of type XI collagen by bovine intervertebral disc- and articular cartilage extracts.
Bovine intervertebral disc- and articular cartilage extracts contain a metalloproteinase system capable of degrading type XI collagen. The collagen-degrading activity is rather low in unmodified extracts but increases considerably on metalloproteinase activation. The similarity between intervertebral disc and articular cartilage in their patterns of (casein-degrading) metalloproteinases and type XI and type II collagen degradation is believed to suggest a similarity in the events underlying the degradative disorders of articular cartilage and intervertebral disc.
Podrazký
V
V
Institute of Rheumatology, Prague, Czech Republic.
Stovícková
J
J
Novotná
J
J
Trnavský
K
K
D000818:Animals; D002358:Cartilage, Articular / Q000201:enzymology / Q000378:metabolism*; D002417:Cattle; D003094:Collagen / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D007202:Indicators and Reagents; D007403:Intervertebral Disc / Q000201:enzymology / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000378:metabolism; D008970:Molecular Weight
D007202:Indicators and Reagents; D003094:Collagen; D008666:Metalloendopeptidases