[Study on plasma levels of vasoactive intestinal peptide (VIP) in patients with allergic rhinitis].
The plasma levels of vasoactive intestinal peptide (VIP) were measured in 33 allergic rhinitis patients and 21 controls by means of supersensitive and highly specific VIP-radioimmunoassays. At the same time the blood flow was observed by using the laser-Doppler flowmetry. The result showed that the levels of plasma VIP in patients with allergic rhinitis were higher than those in the control group (54.93 +/- 30.58 ng/L, 25.97 +/- 11.83 ng/L, P < 0.01). The levels of plasma VIP related significantly to the volume of blood flow in nasal mucosa (gamma = 0.7678, P < 0.001). It is concluded that VIP could induce vasodilation in nasal mucosa, leading to an increase in nasal mucosa blood flow.
Zhang
R X
RX
Changhai Hospital of Second Military Medical University, Shanghai.
D000293:Adolescent; D000328:Adult; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D009297:Nasal Mucosa / Q000098:blood supply; D011863:Radioimmunoassay; D012039:Regional Blood Flow; D012221:Rhinitis, Allergic, Perennial / Q000097:blood*; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
D014660:Vasoactive Intestinal Peptide