Metal-induced developmental toxicity in mammals: a review.
It is well established that certain metals are toxic to embryonic and fetal tissues and can induce teratogenicity in mammals. The main objective of this paper has been to summarize the toxic effects that excesses of certain metals may cause on mammalian development. The reviewed elements have been divided into four groups: (a) metals of greatest toxicological significance (arsenic, cadmium, lead, mercury, and uranium) that are wide-spread in the human environment, (b) essential trace metals (chromium, cobalt, manganese, selenium, and zinc), (c) other metals with evident biological interest (nickel and vanadium), and (d) metals of pharmacological interest (aluminum, gallium, and lithium). A summary of the therapeutic use of chelating agents in the prevention of metal-induced developmental toxicity has also been included. meso-2,3-Dimercaptosuccinic acid (DMSA) and sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) have been reported to be effective in alleviating arsenic- and mercury-induced teratogenesis, whereas sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) would protect against vanadium- and uranium-induced developmental toxicity.
Domingo
J L
JL
Laboratory of Toxicology and Biochemistry, School of Medicine, Rovira i Virgili University, Reus, Spain.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004781:Environmental Exposure; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D008322:Mammals; D008670:Metals / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011247:Pregnancy; D013723:Teratogens / Q000633:toxicity*
D002614:Chelating Agents; D008670:Metals; D013723:Teratogens