Vasoactive intestinal peptide: role of calmodulin and catalytic antibodies.
In the accompanying article Paul and Ebadi [1993 (Neurochem Int. 23, 197-214)] review recent observations that the neuropeptide vasoactive intestinal peptide (VIP) and the related peptide growth hormone releasing factor (GRF) bind to two novel protein molecules unrelated to their G-protein coupled receptors. VIP and GRF have been reported to bind with high affinity to calmodulin, leading to modulation of biological activities of the regulatory protein. VIP has also been reported to bind to autoantibodies isolated from both normal and asthmatic subjects. Several of these autoantibodies have been found to catalyze the hydrolysis of the native VIP molecule. The biological consequences of the binding of VIP and GRF to these macromolecular "receptors" are considered.
Bolin
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Roche Research Center, Hoffmann-La Roche, Inc., Nutley, NJ 07110.
D000818:Animals; D000906:Antibodies / Q000378:metabolism / Q000502:physiology*; D000911:Antibodies, Monoclonal / Q000378:metabolism; D001323:Autoantibodies / Q000378:metabolism / Q000502:physiology; D002147:Calmodulin / Q000378:metabolism / Q000502:physiology*; D002384:Catalysis; D006801:Humans; D018013:Receptors, Neuropeptide / Q000378:metabolism; D018017:Receptors, Pituitary Hormone-Regulating Hormone / Q000378:metabolism; D018005:Receptors, Vasoactive Intestinal Peptide / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism* / Q000502:physiology*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D002147:Calmodulin; D018013:Receptors, Neuropeptide; D018017:Receptors, Pituitary Hormone-Regulating Hormone; D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide; C048250:somatotropin releasing hormone receptor