title: Treatment of FIGO stage Ib cervical carcinoma with nodal involvement.
abstract: One hundred and eighty one patients with stage Ib cervical cancer underwent hysterectomy with pelvic lymphadenectomy. The overall incidence of lymph node metastases was 20%. Twenty seven (71%) patients with nodal involvement were treated by external radiotherapy (TCT) and 11 (29%) by both chemotherapy and radiotherapy (Lin. Acc.). The overall survival at 5 years was 80%; it was 43% for patients with positive nodes and 89% for patients without metastatic nodal disease. The 3 year survival of patients with positive nodes who underwent radiation therapy by TCT was 58%, while it was 72% for those treated by chemotherapy plus radiotherapy. We observed a recurrence in 23% of the cases, 52% in patients with positive nodes and 15% in those with negative nodes. The association chemo-radiotherapy in patients with metastatic lymph nodes seems to improve the survival and reduce the recurrence rate.
authors.affiliation: Istituto di Ginecologia e Ostetricia dell'Università di Genova.
authors.forename: F
authors.initials: F
authors.lastname: Pedullà
authors.forename: M G
authors.initials: MG
authors.lastname: Centurioni
authors.forename: G
authors.initials: G
authors.lastname: Foglia
authors.forename: I
authors.initials: I
authors.lastname: Ferrari
authors.forename: M
authors.initials: M
authors.lastname: Orsatti
authors.forename: V
authors.initials: V
authors.lastname: Vitale
authors.forename: N
authors.initials: N
authors.lastname: Ragni
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary / Q000601:surgery; D002588:Cesium Radioisotopes / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology* / Q000532:radiotherapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*
chemical_list: D002588:Cesium Radioisotopes; D002945:Cisplatin