Ibuprofen treatment of ischemic musculocutaneous flaps.
The nonsteroidal antiinflammatory drug ibuprofen was tested as a potential agent in the pharmacological management of ischemia and reperfusion injury of swine flaps. After 6 hours of global ischemia, ibuprofen treatment was found to significantly improve the postischemic musculocutaneous flap survival. This was demonstrated by a dramatic 30.4 +/- 9.3% (p < or = 0.005) improvement in ischemic muscle survival, whereas the skin survival of ischemic musculocutaneous flaps was only moderately improved by 6.0 +/- 3.2% (p < or = 0.05). Thus, ibuprofen is potentially a powerful and effective treatment agent in the management of critically ischemic flaps and replants with high skeletal muscle content.
Lee
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Microsurgical Research Laboratories, Royal Victoria Hospital, Montreal, Quebec, Canada.
Kerrigan
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D000818:Animals; D006085:Graft Survival / Q000187:drug effects; D007052:Ibuprofen / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology; D009132:Muscles / Q000098:blood supply / Q000637:transplantation*; D015427:Reperfusion Injury / Q000188:drug therapy / Q000209:etiology; D012867:Skin / Q000098:blood supply*; D016038:Skin Transplantation / Q000009:adverse effects*; D013524:Surgical Flaps; D013552:Swine
D007052:Ibuprofen