Effect of intravenous lidocaine on intraabdominal pressure response to airway stimulation.
We evaluated the effect of intravenous (i.v.) lidocaine (1 or 2 mg/kg) on increases in intraabdominal pressure (IAP) due to carinal stimulation in anesthetized patients. IAP was measured continuously using a transurethral bladder catheter. Before administration of lidocaine, carinal stimulation by suction catheter increased IAP compared with baseline values (P < 0.05). After i.v. administration of 1 mg/kg of lidocaine, carinal stimulation produced no change in IAP for 5 min, but IAP increased more than baseline at 7 min (P < 0.05); 2 mg/kg of lidocaine suppressed increase in IAP due to carinal stimulation until 7 min. Changes in IAP at 7 min were 42.2 +/- 12.2 mmHg in the 1 mg/kg group and 10.8 +/- 2.6 mmHg in the 2 mg/kg (P < 0.05). We conclude that increase in IAP caused by carinal stimulation is attenuated by i.v. lidocaine, and this effect continues for 5 min from 1 mg/kg of lidocaine and at least for 7 min from 2 mg/kg after administration.
Nakayama
M
M
Department of Anesthesiology, Sapporo Medical University and Hospital, Japan.
Fujita
S
S
Kanaya
N
N
Namiki
A
A
D000005:Abdomen / Q000502:physiology*; D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D010812:Physical Stimulation; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*
D008012:Lidocaine