Potentiation of synaptic transmission by neuropeptide AVP4-8 (ZNC(C)PR) in rat hippocampal slices.
The effect of AVP4-8 on synaptic transmission in rat hippocampal slices was studied using both extracellular and intracellular recording. AVP4-8 induced a long-lasting potentiation effect on the evoked EPSP and enhanced LTP in pyramidal neurones. The lowest effective concentration of AVP4-8 was 1 x 10(-12) M, three to four orders of magnitude lower than that of AVP. These findings support the concept that AVP4-8 is a new memory-enhancing peptide and should be written as ZNC(C)PR. The results show that the potentiation effect of ZNC(C)PR is mainly due to a presynaptic mechanism of action.
Rong
X W
XW
Shanghai Institue of Physiology, Chinese Academy of Sciences.
Chen
X F
XF
Du
Y C
YC
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D010446:Peptide Fragments; D001127:Arginine Vasopressin; C072508:argipressin (4-8)