title: Correlation between various ratios of serum thyroid hormones and liver cytochrome P-450 in CCl4-treated and untreated rats.
abstract: In a search for clinically useful indices of liver microsomal function, the correlation between various ratios of serum thyroid hormones, triiodothyronine (T3) and reverse T3 (rT3), and liver microsomal P-450 was investigated in CCl4-treated and untreated rats. Serum and liver samples were obtained before (untreated group, n = 15) and 4 hr after CCl4 administrations (0.2 ml/kg, s.c.). The CCl4-treated group (n = 11) included five randomly chosen untreated rats. In both groups, the ratios of T3/rT3, rT3/T3, and T3/T3+rT3 correlated significantly with liver cytochrome P-450 levels. From these results, it is suggested that the ratios of T3/T3+rT3, T3/rT3, and rT3/T3 can be used as the indices of liver microsomal P-450 levels and that thyroid hormone metabolism is related to liver cytochrome P-450, as was evidenced in untreated animals.
authors.affiliation: Third Department of Internal Medicine, Saitama Medical School, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yamagishi
authors.forename: T
authors.initials: T
authors.lastname: Komoda
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
authors.forename: S
authors.initials: S
authors.lastname: Itoh
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D013974:Thyroxine