title: A 28 kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation.
abstract: A 28 kDa-protein with inhibitory activity on collagen- and ADP-induced platelet aggregation was purified from the venom of the snake Bothrops jararaca. Its complete amino acid sequence corresponded to the carboxyl-terminal region consisting of disintegrin-like and cysteine-rich domains of jararhagin, a high molecular weight hemorrhagic metalloprotease. Sequence homology of the protein to other disintegrins and disintegrin-like proteins from various snake venoms is also presented.
authors.affiliation: Department of Pharmaceutics, Gifu Pharmaceutical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Usami
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimura
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Shima
authors.forename: E
authors.initials: E
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Yoshioka
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Titani
mesh_terms: D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000595:Amino Acid Sequence; D003094:Collagen / Q000037:antagonists & inhibitors; D003435:Crotalid Venoms / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008666:Metalloendopeptidases / Q000737:chemistry / Q000494:pharmacology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D000097146:Bothrops jararaca Venom
chemical_list: D000244:Adenosine Diphosphate; D003094:Collagen; D003435:Crotalid Venoms; D008666:Metalloendopeptidases; D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; D000097146:Bothrops jararaca Venom