title: Relationship between lung tissue and blood plasma concentrations of inhaled budesonide.
abstract: In 11 patients, in whom a lung lobe or whole lung was to be resected, a single dose of 1.6 mg inhaled budesonide was given pre-operatively. In 9 of them, concentrations of the drug in both lung tissue and blood plasma were measured. Budesonide concentrations in lung tissue, at least 90 min after dosage, were 2.1-8.9 nmol kg-1. Concentrations in blood plasma (0.27-1.1 nmol kg-1) were 1/8th of those in lung tissue.
authors.affiliation: Department of Chest Diseases, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Van den Bosch
authors.forename: C J
authors.initials: CJ
authors.lastname: Westermann
authors.forename: J
authors.initials: J
authors.lastname: Aumann
authors.forename: S
authors.initials: S
authors.lastname: Edsbäcker
authors.forename: M
authors.initials: M
authors.lastname: Tönnesson
authors.forename: O
authors.initials: O
authors.lastname: Selroos
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000368:Aged; D019819:Budesonide; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011282:Pregnenediones / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D000336:Aerosols; D005938:Glucocorticoids; D011282:Pregnenediones; D019819:Budesonide