Effects of a single administration of buspirone on catalepsy, yawning and stereotypy in rats.
In the present study, the effects of a single administration of buspirone (0.1, 0.3, 1.0, and 3.0 mg/kg sc-30 min before testing) on three dopamine-related behaviors were evaluated in 4-month old male Wistar rats (7-10 animals per group). Buspirone decreased haloperidol (2.0 mg/kg ip)-induced catalepsy in a dose-dependent manner (from 7.30 to 5.09 1n of s compared to the untreated control group). Apomorphine (0.06 mg/kg sc)-induced yawning was also dose-dependently reduced (from 26.7 to 0.9 yawns in 30 min) and so was apomorphine (1.0 mg/kg sc)-induced stereotypy (from 32.9 to 5.9, sum of scores). The present results indicate that buspirone presents unique pharmacological effects related to dopaminergic transmission not only in biochemical but also in behavioral terms.
Conceição
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Departamento de Farmacologia, Escola Paulista de Medicina, São Paulo, Brasil.
Frussa-Filho
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R
D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D002065:Buspirone / Q000008:administration & dosage* / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D006220:Haloperidol / Q000037:antagonists & inhibitors; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D015000:Yawning / Q000187:drug effects*
D006220:Haloperidol; D001058:Apomorphine; D002065:Buspirone