title: The reduction of postoperative adhesions by two different barrier methods versus control in cynomolgus monkeys: a prospective, randomized, crossover study.
abstract: OBJECTIVE
  To determine the effectiveness of two different surgical membranes in preventing postoperative adhesions as compared with control and to evaluate the benefit as compared with "second-look" adhesiolysis.
  
  
  METHODS
  A randomized, prospective, crossover study.
  
  
  METHODS
  A colony of individually caged non-human primates, Department of Obstetrics and Gynecology, Eastern Virginia Medical School Norfolk, Virginia.
  
  
  METHODS
  Hysterotomy or adhesiolysis at the time of exploratory laparotomy, with subsequent scoring of adhesions based on area, vascularity, tenacity, and adhesion score.
  
  
  RESULTS
  The combined crossover data reveal that both surgical barriers are superior in adhesion prevention to microsurgical technique alone. Expanded polytetrafluoroethylene (Gore-Tex Surgical Membrane; WL Gore and Associates, Flagstaff, AZ) was better than oxidized regenerated cellulose (Interceed; Johnson and Johnson Medical, Inc., Arlington, TX) with respect to adhesion area, tenacity, and vascularity, with a significant improvement in the total adhesion score. Second-look adhesiolysis resulted in significant adhesion reduction in the control group, making second-look adhesiolysis statistically similar to the use of either barrier alone (without subsequent adhesiolysis). Gore-Tex removal does not result in adhesion formation as determined by third-look surgery.
  
  
  CONCLUSIONS
  Both Interceed and Gore-Tex show a reduction in the prevention of postsurgical adhesions after hysterotomy incisions, as compared with microsurgical technique alone. Second-look adhesiolysis is as effective as either barrier in the reduction of permanent pelvic adhesions.
authors.affiliation: Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
authors.forename: D R
authors.initials: DR
authors.lastname: Grow
authors.forename: H J
authors.initials: HJ
authors.lastname: Seltman
authors.forename: C C
authors.initials: CC
authors.lastname: Coddington
authors.forename: G D
authors.initials: GD
authors.lastname: Hodgen
mesh_terms: D000818:Animals; D005260:Female; D007044:Hysterectomy / Q000009:adverse effects; D008252:Macaca fascicularis; D008722:Methods; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*