title: Granulocytic sarcoma showing chromosomal changes other than the t(8;21).
abstract: Cytogenetic analysis of a granulocytic sarcoma showed a 46,XX,der(X)t(X;1) (q28;q22), inv(3)(p21q27), inv(9)(p13q22),t(12;22)(p11;q11) karyotype. In addition, bone marrow aspirate disclosed the presence of cells with a 46,XX,inv(3)(p21q27),inv(9)(p13q22)(p11;q11) chromosomal pattern while the patient was clinically aleukemic. This case demonstrates that chromosomal abnormalities other than the classical t(8;21) can also be associated with granulocytic sarcoma.
authors.affiliation: Department of Cytogenetics, Hôpital Universitaire Brugmann, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Heimann
authors.forename: E
authors.initials: E
authors.lastname: Vamos
authors.forename: A
authors.initials: A
authors.lastname: Ferster
authors.forename: E
authors.initials: E
authors.lastname: Sariban
mesh_terms: D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008198:Lymph Nodes / Q000648:ultrastructure; D014178:Translocation, Genetic