[The effect of calcium antagonists on the biochemical and immune status of hypertension patients].
The immunological and biochemical parameters were studied in patients with Stage II hypertensive disease (HD) before and 2 months after course treatment with calcium antagonists of the dihydropyridine series (siscor and nitrepine). The metabolic mechanisms of the therapeutical action of these drugs were found to affect all specific features of the immune and biochemical status typical of hypertensives. One should identify the priority links which are unambiguously positive and the next links which rank to them, i. e. those manifested themselves in impaired adaptive processes whereby the sick body ensures protection from the disease. The priority links include reduction of hypercortisole- and insulinemia, increase in incretion of testosterone to the reference values, stabilization and sensitization of cellular membranes, decrease of beta 2-microglobulinemia, as well as moderate activation of the immune system and mechanisms of protein synthesis in the cells. The latter links comprise a drop of alpha-cholesterol (HDL) in persistent hypertriglyceridemia, additional tension of hepato- and cardiomyocytic functions, a tendency to cell aging and, partially, reversion of the established sexual hormone ratio.
Dlusskaia
I G
IG
Petrova
T V
TV
Bobrovnitskiĭ
I P
IP
Striuk
R I
RI
Orlova
T A
TA
Iakovleva
I P
IP
Dzhenzhera
L Iu
LIu
Mar'ianovskiĭ
A A
AA
Kustova
L A
LA
Fomin
A N
AN
D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015737:Nisoldipine / Q000627:therapeutic use*; D009568:Nitrendipine / Q000627:therapeutic use*; D013997:Time Factors
D015737:Nisoldipine; D009568:Nitrendipine
Vliianie antagonistov kal'tsiia na biokhimicheskiĭ i immunnyĭ status u bol'nykh gipertonicheskoĭ bolezn'iu.