title: Associations between HLA frequencies and pathogenic features of human immunodeficiency virus type 1 infection in seroconverters from the Amsterdam cohort of homosexual men.
abstract: HLA-disease associations may be important for understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. Therefore, 106 homosexual men from the Amsterdam Cohort Study on AIDS with a known date of HIV-1 seroconversion were serologically typed for HLA. Several significant associations between HLA type and pathogenic features of HIV-1 infection were observed: Subjects with fever and skin rash during primary HIV-1 infection showed an increased frequency of HLA-B62 (relative risk [RR], 5.8; P = .005). The frequency of HLA-B35 was increased in subjects with a rapid decline in CD4+ T lymphocytes (RR, 3.2; P = .021). Kaplan-Meier survival analysis revealed a significant association between HLA-B35 and a decrease in CD4+ cells to < 200/microL (P = .01). The strongest association was found between HLA-DR1 and AIDS-related Kaposi's sarcoma (RR, 22.5; P < .001), also confirmed in survival analysis (P = .001). In AIDS patients with only opportunistic infections, increased frequencies of HLA-DR3 (P = .011) and -DQ2 (P = .007) were observed. Finally, the occurrence of syncytium-inducing HIV-1 variants was significantly associated with HLA-DQ2 (P = .01).
authors.affiliation: Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam.
authors.forename: M R
authors.initials: MR
authors.lastname: Klein
authors.forename: I P
authors.initials: IP
authors.lastname: Keet
authors.forename: J
authors.initials: J
authors.lastname: D'Amaro
authors.forename: R J
authors.initials: RJ
authors.lastname: Bende
authors.forename: A
authors.initials: A
authors.lastname: Hekman
authors.forename: B
authors.initials: B
authors.lastname: Mesman
authors.forename: M
authors.initials: M
authors.lastname: Koot
authors.forename: L P
authors.initials: LP
authors.lastname: de Waal
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
authors.forename: F
authors.initials: F
authors.lastname: Miedema
mesh_terms: D015331:Cohort Studies; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology*; D015497:HIV-1 / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006716:Homosexuality; D006801:Humans; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010641:Phenotype
chemical_list: D006680:HLA Antigens