title: [Primary primitive neuroectodermal tumor of the kidney in an adult. Clinico-pathologic and immunohistochemical case report].
abstract: We report a case of a primary renal primitive neuroectodermal tumour in a 24-year-old man associated with multiple pulmonary metastases. Histologically, the bulk of the kidney was replaced by a small round-cell tumour with numerous true Homer-Wright rosettes and perivascular pseudorosettes; wide-spread vascular invasion was noted. There was no evidence at autopsy of a primary tumour elsewhere. Immunohistochemically, the tumour cells stained strongly positive for O-13, a monoclonal antibody, which recognizes a recently described cell membrane glycoprotein (p30/32MIC2), more weakly for NSE and at least focally for PGP 9.5; the tumour did not stain for other neural markers, cytokeratin, leucocyte common antigen, or desmin. The differential diagnosis of small round-cell tumours in this location and the relation of primitive neuroectodermal tumours and Ewing's sarcoma are discussed.
authors.affiliation: Department of Urology, St. Thomas's Hospital (U.M.D.S.), London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Mentzel
authors.forename: M I
authors.initials: MI
authors.lastname: Bultitude
authors.forename: C D
authors.initials: CD
authors.lastname: Fletcher
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D009336:Necrosis; D009360:Neoplastic Cells, Circulating; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology* / Q000556:secondary / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Primärer primitiver neuroektodermaler Tumor der Niere bei einem Erwachsenen. Klinisch pathologischer und immunhistochemischer Fallbericht.