[The behavioral and neurochemical changes in rats caused by the subchronic administration of haloperidol].
Rat experiments showed that subchronic haloperidol enhanced or perverted motor asymmetry appearing in response to apomorphine, resulted in imbalance between the dopaminergic and serotoninergic systems and increased norepinephrine levels. It was concluded that intra- and interhemispheric imbalance might be one of the causes of extrapyramidal disorders associated with the long-term administration of the neuroleptic.
Shevchenko
T P
TP
Tolpyshev
B A
BA
Zban'
L N
LN
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000032:analysis / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000503:physiopathology; D006220:Haloperidol / Q000008:administration & dosage*; D008297:Male; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000378:metabolism; D013997:Time Factors
D012701:Serotonin; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine
Povedencheskie i neĭrokhimicheskie izmeneniia u krys, vyzvannye subkhronicheskim vvedeniem galoperidola.