title: [The echo-Doppler evaluation of the effects of glucagon on the portal flow in normal subjects. The premise for the loading test in portal hypertension].
abstract: This study was aimed at evaluating the capabilities of Doppler US in the quantitative study of portal blood flow after glucagon administration in normal subjects. While its role in the qualitative study of portal hemodynamics is well known, it remains questionable whether Doppler US may be a valuable tool for the quantitative study of portal blood velocity. This may be solved by introducing, on a routine basis, meal tests which may provide a relative evaluation of the data. To date, these tests were based on the evaluation of blood flow velocity before and after a complete meal. For a more reliable test, we suggest that the meal be substituted with the i.v. administration of glucagon, which is known to play a major role in splanchnic hemodynamics during digestion. We examined 30 healthy volunteers and showed the possibility of a statistically significant evaluation of portal blood flow velocity before and after glucagon administration. After glucagon administration, blood flow velocity increased by 31.3% in 10 minutes, on the average, in all the healthy subjects.
authors.affiliation: Istituto di Scienze Radiologiche e Formazione dell'Immagine, Università di Chieti.
authors.forename: F
authors.initials: F
authors.lastname: Renda
authors.forename: A
authors.initials: A
authors.lastname: Olivieri
authors.forename: L
authors.initials: L
authors.lastname: Migliorato
authors.forename: G
authors.initials: G
authors.lastname: Sanità di Toppi
authors.forename: C
authors.initials: C
authors.lastname: Colagrande
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D005934:Glucagon; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011168:Portal System / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D012016:Reference Values; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D005934:Glucagon
vernacular_title: Valutazione con eco-Doppler degli effetti del glucagone sul flusso portale nei soggetti normali. Premessa per la prova da carico nell'ipertensione portale.