title: Cushing's syndrome secondary to olfactory neuroblastoma.
abstract: A case of olfactory neuroblastoma in a 36-year-old woman who presented with florid Cushing's syndrome is reported. A nasal polyp, which proved to be an olfactory neuroblastoma, was resected. The procedure was followed by complete remission from the endocrinologic abnormalities. Postoperatively, the patient was well for 5 years until recurrence of both Cushing's syndrome and the nasal polyp was noted. Following combined transnasal-transcranial resection of the tumor, which extended into the anterior cranial fossa, the patient again experienced complete remission of Cushing's syndrome. Immunohistochemistry showed the tumor to be positive for neuron-specific enolase, synaptophysin, chromogranin, adrenocorticotropic hormone, beta-endorphin, and S-100 protein. Electron microscopy revealed neuritic processes containing microtubules and neurosecretory granules. This is the first reported case of Cushing's syndrome secondary to olfactory neuroblastoma.
authors.affiliation: Department of Pathology, Abbott Northwestern Hospital, Minneapolis, Minnesota 55407.
authors.forename: M A
authors.initials: MA
authors.lastname: Arnesen
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: S
authors.initials: S
authors.lastname: Freeman
mesh_terms: D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology* / Q000628:therapy; D018304:Esthesioneuroblastoma, Olfactory / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D012074:Remission Induction