Expression of 11 beta-OHSD along the nephron of mammals and humans.
The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) plays a major role in the protection of the mineralocorticoid receptor (MR). This cellular mechanism of aldosterone selectivity relies on the coexpression of MR and 11 beta-OHSD in the same cells. Localization of renal 11 beta-OHSD along the nephron is reviewed; comparison of data contained in different species is made; and original data is presented to show that the catalytic activity of the enzyme in tubules from human kidney is the highest in the mineralocorticoid-sensitive distal nephron.
Kenouch
S
S
INSERM U246, UER Xavier Bichat, Paris, France.
Alfaidy
N
N
Bonvalet
J P
JP
Farman
N
N
D042842:11-beta-Hydroxysteroid Dehydrogenases; D000818:Animals; D002384:Catalysis; D003345:Corticosterone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D008901:Mineralocorticoids / Q000494:pharmacology; D009399:Nephrons / Q000201:enzymology*; D014018:Tissue Distribution
D008901:Mineralocorticoids; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003345:Corticosterone; D006854:Hydrocortisone