title: (6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway.
abstract: (6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 micrograms ml-1), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight-1). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine.
authors.affiliation: ZENECA Pharmaceuticals, Alderly Park, Macclesfield, United Kingdom.
authors.forename: G M
authors.initials: GM
authors.lastname: Davies
authors.forename: K J
authors.initials: KJ
authors.lastname: Barrett-Bee
authors.forename: D A
authors.initials: DA
authors.lastname: Jude
authors.forename: M
authors.initials: M
authors.lastname: Lehan
authors.forename: W W
authors.initials: WW
authors.lastname: Nichols
authors.forename: P E
authors.initials: PE
authors.lastname: Pinder
authors.forename: J L
authors.initials: JL
authors.lastname: Thain
authors.forename: W J
authors.initials: WJ
authors.lastname: Watkins
authors.forename: R G
authors.initials: RG
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000517:prevention & control; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000378:metabolism* / Q000494:pharmacology; D013552:Swine
chemical_list: C087313:6-fluoroshikimic acid; D000900:Anti-Bacterial Agents; D012765:Shikimic Acid