Prevention of cesarean section. Does intracervical dinoprostone work?
We investigated the effect of preinduction cervical ripening with the intracervical instillation of dinoprostone (prostaglandin E2 gel, 0.5 mg) on the results of labor induced with intravenous oxytocin. We randomly allocated 79 pregnant women to receive either the intracervial application of dinoprostone gel or placebo gel. Compared with control subjects, the group who received dinoprostone had no difference in induction-to-delivery interval or in cesarean section rate. The dinoprostone group had fewer failed inductions, but there was no difference between the two groups in the number who delivered spontaneously within 24 hours. From review of the literature and a meta-analysis, it was likewise revealed that dinoprostone did not favorably affect the cesarean section rate. Contrary to current opinion, intracervical dinoprostone gel does not appreciably lower the cesarean section rate when used at this dose and route before labor is induced.
Gilson
G J
GJ
Department of Obstetrics and Gynecology, University of New Mexico Hospital, Albuquerque.
Izquierdo
L A
LA
Chatterjee
M S
MS
Curet
L B
LB
Qualls
C R
CR
D000282:Administration, Intravaginal; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects; D002585:Cesarean Section; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010121:Oxytocin / Q000008:administration & dosage; D011247:Pregnancy; D011292:Premedication
D010121:Oxytocin; D015232:Dinoprostone