title: [Perioperative teicoplanin prophylaxis in patients undergoing breast reconstruction with the abdominal wall. A case-control study].
abstract: The authors report the results of a randomized clinical trial of antibiotic prophylaxis of postoperative infection following breast reconstruction by transposition of rectus abdominis myocutaneous flap (TRAMF). The aim was to evaluate the efficacy and tolerability of a short-term parenteral prophylaxis with Teicoplanin and the end-point of the study was the evaluation of wound contamination assessed by means of microbiologic culture of drainage fluid. From October 1990 to March 1992 38 patients were recruited: 20 patients in the antibiotic prophylaxis arm and 18 patients in the control group. Analysis of drainage fluids showed a higher contamination rate (15/18 = 83%) in the control group as compared to the prophylaxis arm (2/20 = 10%) (p < 0.0001). Moreover, 11 patients in the control arm suffered from fever > 37.5 degrees C for at least 3 days as compared to 1 patient in the antibiotic prophylaxis group; the postoperative stay was 13.3 +/- 4.3 and 9.0 +/- 1.6 in the control and antibiotic arm respectively. No antibiotic related side effects were evidenced through the study. These results seem to confirm the value of parenteral short-term antibiotic prophylaxis of postoperative infection in such kind of "clean" operative procedure.
authors.affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova.
authors.forename: S
authors.initials: S
authors.lastname: Franchelli
authors.forename: M S
authors.initials: MS
authors.lastname: Leone
authors.forename: E
authors.initials: E
authors.lastname: Vigna
authors.forename: E
authors.initials: E
authors.lastname: Raposio
authors.forename: F
authors.initials: F
authors.lastname: Cafiero
authors.forename: M
authors.initials: M
authors.lastname: Costantini
authors.forename: R
authors.initials: R
authors.lastname: Capuzzo
authors.forename: M
authors.initials: M
authors.lastname: Gipponi
authors.forename: P L
authors.initials: PL
authors.lastname: Santi
mesh_terms: D000009:Abdominal Muscles / Q000382:microbiology / Q000637:transplantation*; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods* / Q000706:statistics & numerical data; D008875:Middle Aged; D011292:Premedication / Q000706:statistics & numerical data; D013524:Surgical Flaps / Q000379:methods* / Q000706:statistics & numerical data; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control; D017334:Teicoplanin / Q000627:therapeutic use*
chemical_list: D017334:Teicoplanin
vernacular_title: Profilassi perioperatoria con teicoplanina in pazienti sottoposte a ricostruzione mammaria con retto addominale. Studio caso-controllo.