Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS)
The murine acquired immunodeficiency syndrome (MAIDS) is induced by a defective murine leukemia virus and has many symptoms similar to those found in patients infected with the human immunodeficiency virus. The presence of both B cells and CD4+ T cells is critical for the development of the disease. Furthermore, a Th2 cytokine response dominates during the progression of the disease. When interleukin-4 (IL-4)-deficient mice that are defective in Th2 cytokine responses were infected, there was no lethality, and the development of the T cell abnormalities associated with MAIDS was delayed. These data suggest that IL-4 or a Th2 response is involved in the development of retrovirus-induced immunodeficiency in mice.
Kanagawa
O
O
Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Vaupel
B A
BA
Gayama
S
S
Koehler
G
G
Kopf
M
M
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D015683:Gene Products, gag / Q000235:genetics; D007113:Immunity, Innate; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D009052:Leukemia Virus, Murine / Q000235:genetics; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D017931:DNA Primers; D015683:Gene Products, gag; D007376:Interleukin-2; D012333:RNA, Messenger; D012367:RNA, Viral; D015847:Interleukin-4