Genetics of signal transduction: tales from the mouse.
Recent progress in understanding signal transduction owes much to new genetic approaches, first by unraveling the molecular basis of classic mutations, and then by the use of gene targeting. Recent studies have examined mammalian signal transduction from cell surface to nucleus, especially ligand-receptor systems and cytosolic signal transducers.
Imamoto
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Fred Hutchinson Cancer Research Center, Program in Molecular Medicine, Seattle, Washington 98104.
Soriano
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Stein
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PL
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D008024:Ligands; D051379:Mice; D009154:Mutation; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
D008024:Ligands; D011956:Receptors, Cell Surface