title: Carcinoma of the external auditory meatus and middle ear. Results of the treatment of 28 cases.
abstract: OBJECTIVE
  The authors report their experience on the treatment of 28 cases of middle ear (3) and external auditory meatus (EAM) cancers (25) with surgery and/or radiation therapy. According to histologic type, there were 23 squamous cell carcinomas, 4 basal cell carcinomas and 1 adenocystic carcinoma.
  
  
  METHODS
  Surgery alone was performed in 2 cases, surgery combined with radiotherapy in 11 cases, and radiotherapy alone in 15 cases. Postoperative radiation therapy dose ranged between 4500 and 5500 cGy; the definitive dose was 6000-7000 cGy. The median follow-up was 61 months.
  
  
  RESULTS
  Complete response rate 6 weeks after the end of the treatment, evaluated by CT scan, was 85.7% (24/28). Definitive local control was obtained in 20/28 cases for the primary site and in 26/28 cases for the neck. Nine of the 10 recurrences were retreated with low-dose radiotherapy combined with surgery, chemotherapy or hyperthermia. A new local control was obtained in 2 cases. Four patients were lost during the follow-up at 13, 14, 17 and 23 months after the end of the treatment. The survival rate was 54% (13/24); disease-free survival was 50% (11/22).
  
  
  CONCLUSIONS
  Despite a not very aggressive treatment, our results are quite good.
authors.affiliation: Department of Radiation Therapy, University of Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gabriele
authors.forename: M
authors.initials: M
authors.lastname: Magnano
authors.forename: R
authors.initials: R
authors.lastname: Albera
authors.forename: G
authors.initials: G
authors.lastname: Canale
authors.forename: M G
authors.initials: MG
authors.lastname: Redda
authors.forename: M
authors.initials: M
authors.lastname: Krengli
authors.forename: G L
authors.initials: GL
authors.lastname: Negri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D004424:Ear Canal; D004428:Ear Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D004432:Ear, Middle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome