title: Analysis of longitudinal distribution of pulmonary vascular resistance by use of a five element lumped model.
abstract: To analyze longitudinal distribution of pulmonary vascular resistance, we proposed a five element lumped model which partitioned pulmonary circulation into pulmonary arterial, middle and pulmonary venous segment. The validity and anatomical correlation of the model were tested in an isolated, perfused, canine lung lobe preparation with inflow/outflow occlusion techniques. With arterial occlusion, pulmonary arterial pressure fell rapidly and then exponentially. With venous occlusion, pulmonary venous pressure rose suddenly and then exponentially. Theoretical pressure profiles produced by computer simulation of the model well approximated the general characteristics of the experimental traces. Serotonin increased the pressure gradient across the pulmonary arterial segment (delta Pa), whereas histamine increased the gradient across the pulmonary venous segment (delta Pv). Neither drug altered the gradient across the middle segment (delta Pm). The results suggest that the lumped model is a useful concept to understand the longitudinal distribution of pulmonary vascular resistance, and that delta Pa, delta Pm and delta Pv reflect the resistance distribution of anatomical pulmonary arteries, alveolar vessels and pulmonary veins, respectively.
authors.affiliation: Research Laboratory at Veterinary Medical Teaching Hospital, School of Veterinary Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Washizu
authors.forename: Y
authors.initials: Y
authors.lastname: Matsukura
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Motoyoshi
authors.forename: K
authors.initials: K
authors.lastname: Miyasaka
authors.forename: M
authors.initials: M
authors.lastname: Takata
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D004285:Dogs; D008433:Mathematics; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011652:Pulmonary Circulation / Q000187:drug effects; D011667:Pulmonary Veins / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D012701:Serotonin