title: [Postmortem diagnosis of cardiac amyloidosis in the aged. Anatomoclinical correlation].
abstract: The absence of specific clinical signs makes the diagnosis of cardiac amyloidosis difficult. Moreover, it is established that this condition, the prevalence of which increases with age, aggravates the prognosis of cardiac failure. The present study was undertaken to identify the clinical or paraclinical signs enabling more accurate diagnosis of this disease. Analysis of 2589 autopsy reports from the University Institutes of Geriatrics of Geneva between January 1972 and January 1990 recensed 58 cases of microscopic cardiac amyloidosis, but this diagnosis was not made in any of these patients before death. Of the potential indicators, the good specificity but poor sensitivity of atrial fibrillation and low voltage electrocardiogram was confirmed. On the other hand, the author's research found the association of radiological cardiomegaly and a raised erythrocyte sedimentation rate in nearly 70% of cases of cardiac amyloidosis with a false positive rate of only 10% in a control group.
authors.affiliation: Institutions universitaires de gériatrie, Suisse.
authors.forename: D
authors.initials: D
authors.lastname: Bustos
authors.forename: J J
authors.initials: JJ
authors.lastname: Perrenoud
authors.forename: J P
authors.initials: JP
authors.lastname: Michel
authors.forename: B
authors.initials: B
authors.lastname: Grab
authors.forename: W
authors.initials: W
authors.lastname: McGee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology; D001799:Blood Sedimentation; D006332:Cardiomegaly / Q000453:epidemiology / Q000209:etiology; D009202:Cardiomyopathies / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D013557:Switzerland / Q000453:epidemiology
vernacular_title: Diagnostic post-mortem de l'amyloïdose cardiaque du vieillard. Corrélation anatomoclinique.