title: Studies on anti-allergic components in the roots of Asiasarum sieboldi.
abstract: The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenami de (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD4.
authors.affiliation: Research Institute for Biology & Chemistry, Tsumura & Company, Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Okui
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeya
authors.forename: M
authors.initials: M
authors.lastname: Maruno
authors.forename: T
authors.initials: T
authors.lastname: Fujita
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy*; D008297:Male; D015394:Molecular Structure; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal