[Molecular cloning and multifunctions of membrane-associated 3,5,3'-triiodo-L-thyronine binding protein with protein disulfide isomerase activity].
The protein or cDNA sequencing revealed that the membrane-associated 3,5,3'-triiodo-thyronine binding protein (T3BP) acts as a multifunctional protein:protein disulfide isomerase (PDI) catalyzing isomerization of intra- and inter-molecular disulfide bridge in the proteins, beta-subunit of prolyl 4-hydroxylase catalyzing the formation of 4-hydroxyproline in collagen molecules, glycosylation site binding protein which is a component of oligosaccharyl transferase transferring oligosaccharide chains to the asparagine residues of Asn-X-Ser/Thr site in nascent polypeptide, and a component of triglyceride transfer protein complex involved in the transfer unit of triglyceride, cholesteryl ester and phosphatidylcholine between biomembranes. The functions of 55 k-T3BP/PDI, mainly involved in important post-translational modifications, are discussed in relation to the domain structure of the molecule.
Horiuchi
R
R
Department of Pharmacy, Gunma University School of Medicine.
Yamauchi
K
K
D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D007535:Isomerases / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D008969:Molecular Sequence Data; D019704:Protein Disulfide-Isomerases; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins
D002352:Carrier Proteins; D018076:DNA, Complementary; D007535:Isomerases; D008565:Membrane Proteins; D019704:Protein Disulfide-Isomerases; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins