Southwestern Internal Medicine Conference: pulmonary complications of high-altitude exposure.
The primary physiologic disturbance at high altitude is hypoxemia, which leads to a cascade of secondary changes in each step of the oxygen-transport chain. The author, in this review, focuses on the alterations in ventilatory control and alveolar-capillary gas exchange at high altitude and discusses the clinical pulmonary complications associated with these alterations, as well as their prevention and management.
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Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.
D000064:Acclimatization; D000086:Acetazolamide / Q000627:therapeutic use; D000208:Acute Disease; D000531:Altitude; D000532:Altitude Sickness / Q000188:drug therapy / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008168:Lung / Q000254:growth & development / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D011086:Polycythemia / Q000209:etiology; D011654:Pulmonary Edema / Q000209:etiology; D012119:Respiration; D013997:Time Factors
D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D000086:Acetazolamide; D010100:Oxygen