title: Parallel induction of nitric oxide and glucose-6-phosphate dehydrogenase in activated bone marrow derived macrophages.
abstract: The production of nitric oxide (NO.) and the induction of glucose-6-phosphate dehydrogenase by lipopolysaccharides (LPS) from different sources was studied in bone marrow derived macrophages (BMM phi). NO. production was found to be linked to the induction of glucose-6-phosphate dehydrogenase, suggesting the possible involvement of this enzyme in the cytotoxic mechanism resulting from the release of NO. by activated macrophages.
authors.affiliation: Departamento de Bioquímica, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
authors.forename: I M
authors.initials: IM
authors.lastname: Corraliza
authors.forename: M L
authors.initials: ML
authors.lastname: Campo
authors.forename: J M
authors.initials: JM
authors.lastname: Fuentes
authors.forename: S
authors.initials: S
authors.lastname: Campos-Portuguez
authors.forename: G
authors.initials: G
authors.lastname: Soler
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D003513:Cycloheximide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005269:Femur / Q000166:cytology / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000502:physiology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D016992:Rhodobacter / Q000276:immunology; D012475:Salmonella / Q000276:immunology; D013855:Thiobacillus / Q000276:immunology
chemical_list: D008070:Lipopolysaccharides; D009569:Nitric Oxide; D003513:Cycloheximide; D005954:Glucosephosphate Dehydrogenase