Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity.
Hb Poitiers or alpha 45(CE3)His-->Asp was found in a 9-year-old French Caucasian boy. The structural modification concerns a heme contact and is responsible for an increased oxygen affinity and a faster than normal rate of autooxidation.
Bardakdjian
J
J
INSERM U91, Hôpital Henri Mondor, Créteil, France.
Kister
J
J
Wajcman
H
H
Boulard
P
P
Bohn
B
B
Blouquit
Y
Y
Galacteros
F
F
D000740:Anemia / Q000097:blood / Q000235:genetics*; D001797:Blood Protein Electrophoresis; D002648:Child; D002852:Chromatography, Ion Exchange; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000097:blood / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D008297:Male; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism; D011487:Protein Conformation
D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; C087402:hemoglobin Poitiers; D005914:Globins; D010100:Oxygen