Microanalysis of carbon monoxide in blood by head-space capillary gas chromatography.
A gas chromatographic procedure for the determination of carboxyhaemoglobin in blood was improved by using a capillary system in combination with a micro thermal conductivity detector. This system is very sensitive with high resolutions. The analytical time is reduced to approximately two minutes. Using sulphuric acid as the liberating agent of carbon monoxide, a gradual and reproducible release of carbon monoxide was seen. This shortens the time in emergency cases for sample preparation.
Van Dam
J
J
University of Leuven, Laboratory of Toxicology, Belgium.
Daenens
P
P
D002197:Capillary Action; D002248:Carbon Monoxide / Q000097:blood*; D002263:Carboxyhemoglobin / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods*; D004630:Emergencies; D005069:Evaluation Studies as Topic; D005554:Forensic Medicine / Q000379:methods*; D006801:Humans; D016014:Linear Models; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013464:Sulfuric Acids; D013814:Thermal Conductivity; D013997:Time Factors
D013464:Sulfuric Acids; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; C033158:sulfuric acid