Parallel induction of nitric oxide and glucose-6-phosphate dehydrogenase in activated bone marrow derived macrophages.
The production of nitric oxide (NO.) and the induction of glucose-6-phosphate dehydrogenase by lipopolysaccharides (LPS) from different sources was studied in bone marrow derived macrophages (BMM phi). NO. production was found to be linked to the induction of glucose-6-phosphate dehydrogenase, suggesting the possible involvement of this enzyme in the cytotoxic mechanism resulting from the release of NO. by activated macrophages.
Corraliza
I M
IM
Departamento de Bioquímica, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
Campo
M L
ML
Fuentes
J M
JM
Campos-Portuguez
S
S
Soler
G
G
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D003513:Cycloheximide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005269:Femur / Q000166:cytology / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000502:physiology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D016992:Rhodobacter / Q000276:immunology; D012475:Salmonella / Q000276:immunology; D013855:Thiobacillus / Q000276:immunology
D008070:Lipopolysaccharides; D009569:Nitric Oxide; D003513:Cycloheximide; D005954:Glucosephosphate Dehydrogenase