title: Selective brain cooling increases cortical cerebral blood flow in rats.
abstract: To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38 degrees C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 +/- 26% (mean +/- SE) of baseline at a cortical brain temperature of 30.9 +/- 0.5 degrees C and a rectal temperature of 37.5 +/- 0.1 degrees C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.
authors.affiliation: Department of Pediatrics, University of Miami School of Medicine, Florida 33101.
authors.forename: J W
authors.initials: JW
authors.lastname: Kuluz
authors.forename: R
authors.initials: R
authors.lastname: Prado
authors.forename: J
authors.initials: J
authors.lastname: Chang
authors.forename: M D
authors.initials: MD
authors.lastname: Ginsberg
authors.forename: C L
authors.initials: CL
authors.lastname: Schleien
authors.forename: R
authors.initials: R
authors.lastname: Busto
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001831:Body Temperature; D001921:Brain / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006358:Hot Temperature; D007036:Hypothermia, Induced; D008297:Male; D051381:Rats; D017208:Rats, Wistar