Carbonic anhydrase inhibitors from the pericarps of Punica granatum L.
Seven highly active inhibitors against carbonic anhydrase (CA, EC 4.2.1.1), punicalin (2), punicalagin (3), granatin B (5), gallagyldilactone (7), casuarinin (8), pedunculagin (9) and tellimagrandin I (10), and four weakly active inhibitors, gallic acid (1), granatin A (4), corilagin (6) and ellagic acid (11), were isolated from the pericarps of Punica granatum L. (Punicaceae). They are ellagitannins. The type of inhibition by 3 and 7 using p-nitrophenyl acetate as a substrate, is noncompetitive. The structure-activity relationship of inhibitory effects on CA is discussed.
Satomi
H
H
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Umemura
K
K
Ueno
A
A
Hatano
T
T
Okuda
T
T
Noro
T
T
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000378:metabolism; D002417:Cattle; D047348:Hydrolyzable Tannins / Q000302:isolation & purification* / Q000494:pharmacology; D007700:Kinetics; D009596:Nitrophenols / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013634:Tannins / Q000302:isolation & purification* / Q000494:pharmacology
D002257:Carbonic Anhydrase Inhibitors; D047348:Hydrolyzable Tannins; D009596:Nitrophenols; D010936:Plant Extracts; D013634:Tannins; C013515:ellagitannin; C553162:granatin B; C008642:4-nitrophenyl acetate; D002256:Carbonic Anhydrases