Acyclovir-resistant neonatal herpes simplex virus infection of the larynx.
A 10-day-old infant with stridor was found to have herpes simplex virus type 2 infection of the larynx. The infant's poor clinical response to both acyclovir and foscarnet prompted extensive clinical and virologic evaluations, which revealed acyclovir-resistant herpes simplex virus.
Nyquist
A C
AC
Department of Pediatrics, University of Colorado School of Medicine, Denver.
Rotbart
H A
HA
Cotton
M
M
Robinson
C
C
Weinberg
A
A
Hayward
A R
AR
Berens
R L
RL
Levin
M J
MJ
D000212:Acyclovir / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D006561:Herpes Simplex / Q000188:drug therapy*; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D007818:Laryngeal Diseases / Q000188:drug therapy* / Q000382:microbiology
D017245:Foscarnet; D000212:Acyclovir