Exercise-induced rhabdomyolysis.
OBJECTIVE
To describe the syndrome of exercise-induced rhabdomyolysis and to investigate the relation between exercise-induced rhabdomyolysis and the development of acute renal failure.


METHODS
Retrospective chart analysis on all patients with a discharge diagnosis of rhabdomyolysis from January 1988 to January 1993.


METHODS
An urban tertiary care center with 225,000 annual emergency department visits.


METHODS
Thirty-five patients met the inclusion criteria for exercise-induced rhabdomyolysis: a history of strenuous exercise, creatine phosphokinase level more than 500, and urine dipstick positive for blood without hematuria. We excluded patients with a history of trauma, myocardial infarction, stroke, or documented sepsis. Charts also were examined for the presence of nephrotoxic cofactors (ie, hypovolemia and/or acidosis).


RESULTS
All 35 patients were men without significant past medical history and were an average age of 24.4 years. The average admission creatine phosphokinase was 40,471 U/L. No patient presented with or developed nephrotoxic cofactors during hospitalization. None of our study patients experienced acute renal failure.


CONCLUSIONS
Previous literature has described a 17% to 40% incidence of acute renal failure in rhabdomyolysis. None of our patients developed acute renal failure, signifying a much lower incidence of acute renal failure in exercise-induced rhabdomyolysis without nephrotoxic cofactors than in other forms of rhabdomyolysis.
Sinert
R
R
Department of Emergency Medicine, State University of New York Health Science Center, Brooklyn/Kings County Hospital Center.
Kohl
L
L
Rainone
T
T
Scalea
T
T
D058186:Acute Kidney Injury / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000652:urine; D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D004636:Emergency Service, Hospital; D015444:Exercise; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000652:urine; D012307:Risk Factors
D003402:Creatine Kinase