Efficacy of 4-methylpyrazole in ethylene glycol poisoning: clinical and toxicokinetic aspects.
Potentially fatal ethylene glycol intoxication in an adult with normal renal function was treated with 4-methylpyrazole administered three hours after the incident occurred. The plasma ethylene glycol concentration was 3.5 g l-1 on admission. The metabolic acidosis present on admission resolved within four hours, and the subsequent clinical course was uneventful. The apparent plasma half-life of ethylene glycol was 16 h and the mean renal and plasma clearances of ethylene glycol were 24 and 25 ml min-1, respectively. These results support the hypothesis that complete blockade of hepatic metabolism of ethylene glycol is achieved by 4-methylpyrazole. The only side-effect observed as a result of treatment was a transient slight increase in serum transaminase activity.
Harry
P
P
Centre Anti-Poisons-Réanimation Médicale, CHU, Angers, France.
Turcant
A
A
Bouachour
G
G
Houze
P
P
Alquier
P
P
Allain
P
P
D000328:Adult; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000097:blood / Q000506:poisoning*; D000077604:Fomepizole; D006801:Humans; D008297:Male; D011041:Poisoning / Q000188:drug therapy; D011720:Pyrazoles / Q000627:therapeutic use*
D005026:Ethylene Glycols; D011720:Pyrazoles; D000077604:Fomepizole; D019855:Ethylene Glycol