[The synthesis and bioactivities of cholinergic tropane alkaloids].
Ten analogs of baogongteng A, the natural cholinergic tropane alkaloid isolated from Erycibe obtusifolia Benth, were designed and synthesized. The tropane skeleton was kept unchanged, while the substituting groups on N and C3 were modified. In myotic experiments in rabbits 3-paramethyl benzoyloxy-6-acetoxy nortropane(4), 3-propionyloxy-6-acetoxy nortropane(5), and 3-isobutyryloxy-6-acetoxy nortropane(6) showed cholinergic activities.
Ding
W G
WG
Department of Chemistry, Shanghai Second Medical University.
Yang
L M
LM
Yu
Y M
YM
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008916:Miotics / Q000138:chemical synthesis* / Q000737:chemistry; D010277:Parasympathomimetics / Q000138:chemical synthesis* / Q000737:chemistry; D011817:Rabbits; D014326:Tropanes
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004365:Drugs, Chinese Herbal; D008916:Miotics; D010277:Parasympathomimetics; D014326:Tropanes; C027863:bao gong teng A