Growth rate of acoustic neuroma expressed by Ki-67 nuclear antigen versus symptom duration.
The growth rate of acoustic tumors varies widely. An immunohistochemical study with Ki-67 monoclonal antibody was performed on a random sample of 21 acoustic neuromas. The tumors belonged to 2 well-defined groups: 1 with a short duration of preoperative symptoms (< 1 year) and 1 with a long duration of preoperative symptoms (> 5 years). The tumors were of small to medium size (7 to 27 mm), and no large, cystic, or Recklinghausen tumors were included. The tumor proliferative fraction expressed by monoclonal antibody Ki-67 was determined. The results revealed a significant relation between the tumor proliferative fraction and symptom duration. Tumors with a high proliferative status had a short preoperative symptom duration, while tumors with a low proliferative status had a long symptom duration. The clinical implications of these results are discussed.
Charabi
S
S
Dept of Otorhinolaryngology-Head and Neck Surgery, Gentofte University Hospital, Hellerup, Denmark.
Engel
P
P
Jacobsen
G K
GK
Tos
M
M
Thomsen
J
J
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology
D017730:Ki-1 Antigen