title: Solitary congenital self-healing reticulohistiocytosis.
abstract: Congenital self-healing reticulohistiocytosis (CSHR) was first described in 1973 by Hashimoto and Pritzker. Since then, both multiple and solitary forms have been described. We report a further case of solitary congenital self-healing reticulohistiocytosis. CSHR is a rare disorder which frequently presents a diagnostic dilemma in the newborn. Nodular forms of systemic Langerhans cell histiocytosis may present in a manner similar to CSHR. Because their differentiation on histopathological grounds is impossible, physical examination, laboratory investigations, and follow-up are necessary to ensure a lack of systemic involvement. Although previously thought to represent a rare variant of CSHR, solitary lesions of CSHR account for almost 25% of reported cases. A review of the literature relating to solitary CSHR, and a consideration of the differential diagnosis of a solitary congenital nodule, are also presented.
authors.affiliation: Thomas Jefferson University, Department of Dermatology, Philadelphia, PA 19107-5541.
authors.forename: E F
authors.initials: EF
authors.lastname: Bernstein
authors.forename: K S
authors.initials: KS
authors.lastname: Resnik
authors.forename: J H
authors.initials: JH
authors.lastname: Loose
authors.forename: C
authors.initials: C
authors.lastname: Halcin
authors.forename: Y C
authors.initials: YC
authors.lastname: Kauh
mesh_terms: D006644:Histiocytes / Q000473:pathology / Q000648:ultrastructure; D015616:Histiocytosis, Non-Langerhans-Cell / Q000151:congenital* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins