Correlation of serum ofloxacin concentration and serum creatinine level in patients on prolonged therapy.
Serum ofloxacin concentrations were assessed by high performance liquid chromatography 4 h after drug administration in 86 patients with pulmonary tuberculosis. All patients had multidose, once-daily drug administration (200 mg to 800 mg p.o.) for at least 3 weeks prior to assessment. The serum creatinine levels were simultaneously assessed for these patients. A positive correlation was found between serum ofloxacin (Y) and serum creatinine x dose of ofloxacin administered/body surface area (X). The correlation can be represented mathematically by the equation: Y = 0.87X + 0.68 (r = 0.80, p < 0.001).
Yew
W W
WW
Tuberculosis and Chest Unit, Grantham Hospital, Aberdeen, Hong Kong.
Wong
C F
CF
Wong
P C
PC
Cheung
S W
SW
Chan
C Y
CY
Cheng
A F
AF
D000293:Adolescent; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015242:Ofloxacin / Q000008:administration & dosage* / Q000097:blood* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy*
D015242:Ofloxacin; D003404:Creatinine