Huntington's disease in five siblings.
Huntington's disease is an autosomal dominant neurodegenerative condition which is rare in Singapore. Five siblings with progressive chorea and dementia were treated at the Singapore General Hospital and followed up over a seven-year period. Family history revealed five deceased affected individuals, two living affected siblings and more than 35 "at risk" offspring spanning another two generations each with about a 50% probability of carrying the Huntington's disease gene. We believe this is the largest kindred with Huntington's disease in Singapore.
Wong
M C
MC
Neurology Unit, Singapore General Hospital.
Ng
I S
IS
Lim
S H
SH
D000328:Adult; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010375:Pedigree; D012846:Singapore