[The distribution of deletions in the dystrophin gene in patients with Duchenne muscular dystrophy in Ukraine].
DNA analysis of deletions within 14 exons and promoter region of dystrophin gene was performed in 34 Ukrainian families with high risk of muscular Duchenne dystrophy. The presence of dystrophin gene deletions in different exons was found clustering near central part of dystrophin gene. The necessity of DNA analysis of mutations in dystrophin gene and its use for screening and prenatal diagnosis of muscular Duchenne dystrophy is under discussion.
Grishko
V I
VI
Maliarchuk
S G
SG
Livshits
L A
LA
D016189:Dystrophin / Q000235:genetics*; D005091:Exons / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D009136:Muscular Dystrophies / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D014455:Ukraine / Q000453:epidemiology
D016189:Dystrophin
Raspredelenie nekotorykh deletsiĭ v gene distrofina u bol'nykh myshechnoĭ distrofieĭ Diushena v Ukraine.