[Familial occurrence of esophageal atresia].
Two siblings with esophageal atresia are reported, and literature data as to familial occurrence and heredity have been reviewed. Until now, only statistical data can be given: the recurrence risk for sibs after one affected child is around 0.5-2% and after two affected children around 20%. The risk for the children of a parent affected by congenital esophageal atresia is estimated at around 3-4%. This is compatible with the recurrence risk of a multifactorial condition in first degree relatives. However, two patients have been described in which the possibility of autosomal dominant transmission has been raised.
Casteels
K
K
Dienst Kindergeneeskunde, Universitaire Ziekenhuizen Gasthuisberg K.U. Leuven, België.
Devlieger
H
H
Lerut
T
T
Eggermont
E
E
D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004933:Esophageal Atresia / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007231:Infant, Newborn; D008297:Male
Familiaal voorkomen van slokdarmatresie.