[The significance of a natural inhibitory factor in the pathogenesis of disseminated sclerosis].
Results indicate that during exacerbation patients with multiple sclerosis showed marked T-lymphopenia, decrease of histamine-sensitive RFC while active RFC exhibited varied changes of their content; increase of the circulating immune complexes, absence or low NIF level. The effect of corticosteroid therapy on the NIF dynamics was evaluated and its level was found to be increased due to hormone treatment. Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis. NIF may be used as a prognostic criterion for the evaluation of completeness and duration of the remission. Prolonged functioning of NIF leads to suppression of the patient's immune reactivity requiring immunocorrection.
Dziuba
A N
AN
Frolov
V M
VM
Peresadin
N A
NA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D011379:Prognosis; D013491:Suppressor Factors, Immunologic / Q000187:drug effects / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000936:Antigen-Antibody Complex; D013491:Suppressor Factors, Immunologic
Znachenie estestvennogo ingibiruiushchego faktora v patogeneze rasseiannogo skleroza.