Effects of piracetam on erythropoiesis and leukopoiesis in rats.
Erythro- and leukopoiesis in rats after 10-day treatment with piracetam (2 x 200 mg/kg b.w.) were studied. Increase of reticulocytes and of 59-iron incorporation in newly formed erythrocytes accompanied by an increase of the index of maturation of erythroblasts in bone marrow were found suggesting a piracetam-induced stimulation of erythropoiesis. Piracetam also increased the number of small lymphocytes and the maturation of granulocytes in bone marrow. It is supposed that piracetam exerting a positive effect on the metabolic processes of erythroid, myeloid and lymphoid precursors stimulates their proliferation and differentiation.
Nyagolov
Y
Y
Department of Physiology, Medical University, Varna, Bulgaria.
Dyankov
E
E
Ganchev
T
T
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects*; D007501:Iron / Q000097:blood; D007504:Iron Radioisotopes; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017701:Reticulocyte Count / Q000187:drug effects; D012156:Reticulocytes / Q000187:drug effects
D007504:Iron Radioisotopes; D007501:Iron; D010889:Piracetam