Biosynthetic studies on the origin of the cyclohexanecarboxylic acid moiety of ansatrienin A and omega-cyclohexyl fatty acids.
Feeding experiments with [2,6,10,10-2H4]chorismate in Streptomyces collinus (ansatrienin A) and Alicyclobacillus acidocaldarius (omega-cyclohexyl fatty acids), and inhibitor experiments with glyphosate in the latter organism, have shown that the biosynthesis of cyclohexanecarboxylic acid branches off from the shikimate pathway at a point prior to enolpyruvylshikimate 3-phosphate, either at shikimate or shikimate 3-phosphate.
Moore
B S
BS
Department of Chemistry, University of Washington, Seattle 98195.
Floss
H G
HG
D001406:Bacillaceae / Q000235:genetics / Q000378:metabolism*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D003509:Cyclohexanecarboxylic Acids / Q000378:metabolism*; D003510:Cyclohexanes / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D011809:Quinones / Q000378:metabolism; D000097797:Glyphosate
D003509:Cyclohexanecarboxylic Acids; D003510:Cyclohexanes; D005227:Fatty Acids; D005998:Glycine; D011809:Quinones; D000097797:Glyphosate; C087539:omega-cyclohexylundecanoic acid; C036970:mycotrienin I