[Experimental validation of the efficacy of intraocular phonoelectrophoresis in eye diseases].
Basing on clinical data (12 patients) and experimental results (42 rabbits), the authors defined the pharmacokinetic characteristics of drugs administered by endo-ocular phonoelectrophoresis technique developed by them. Formation of the drugs' depot in the parabulbar space was demonstrated. Concentrations of the administered drugs in various segments of the eyeball were assessed. The values obtained during parabulbar injection of drugs were used as reference ones.
Egorov
E A
EA
Kriukova
M B
MB
Kriukov
A I
AI
D000328:Adult; D000818:Animals; D004586:Electrophoresis; D005069:Evaluation Studies as Topic; D005123:Eye / Q000378:metabolism; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D007930:Leucine / Q000008:administration & dosage / Q000493:pharmacokinetics; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics*; D015612:Phonophoresis; D011817:Rabbits
D009883:Ophthalmic Solutions; D007930:Leucine
Eksperimental'noe obosnovanie tselesoobraznosti primeneniia éndokuliarnogo fonoélektroforeza pri zabolevaniiakh glaza.