Determination of SCH 39304 by megabore capillary gas-liquid chromatography.
A gas-liquid chromatographic procedure for determination of SCH 39304 at low nanogram concentrations in serum, cerebrospinal fluid, and urine is presented. The methodology combines a high selectivity and sensitivity nitrogen-specific detector, a gas chromatograph equipped with a capillary "megabore" column, and an internal standard that is very similar in chemical structure to the drug being assayed. This method is suitable for both pharmacokinetic studies as well as for monitoring drug levels in patients receiving SCH 39304 for antifungal treatment.
Wallace
J E
JE
Department of Pathology, University of Texas Health Science Center at San Antonio 78284-7750.
Mojaverian
P
P
Lin
C C
CC
Kim
H K
HK
Harris
S C
SC
Chen
T J
TJ
Rinaldi
M G
MG
D000935:Antifungal Agents / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D012680:Sensitivity and Specificity; D014230:Triazoles / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine
D000935:Antifungal Agents; D014230:Triazoles; C056513:Sch 39304