[The cholinoreactive system of the neostriatum and the active avoidance behavior of rats in a T maze].
In experiments with 57 Sprague-Dawley male rats was studied the influence of single right- and left-side injections of different doses of choline agonist carbachol and choline blocker scopolamine into the dorsal part of the neostriatum (the head of the caudate nucleus) on active avoidance conditioning in a T-maze and on the locomotor activity. Non-adequately high carbachol doses disturbed the process of conditioning during the whole training period inducing no significant changes in locomotor activity of the rats. Microinjections of carbachol and scopolamine in small doses did not change the process of T-maze conditioning and also did not influence the dynamics and the level of locomotor activity of the experimental rats in comparison with the control ones.
Shapovalova
K B
KB
Pominova
E V
EV
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002217:Carbachol / Q000008:administration & dosage; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000008:administration & dosage; D013997:Time Factors
D011950:Receptors, Cholinergic; D002217:Carbachol; D012601:Scopolamine
Kholinoreaktivnaia sistema neostriatuma i povedenie aktivnogo izbeganiia v T-obraznom labirinte u krys.