title: Concentrations of cefodizime in bronchial secretions after single intravenous administration.
abstract: The concentrations of cefodizime (HR 221, CAS 69739-16-8) in bronchial secretions were measured after administration of a single intravenous bolus of 2 g in 19 patients requiring fibreoptic bronchoscopy for diagnostic purposes or as therapeutic follow-up. These concentrations, which were obtained in absence of inflammation of the mucosa, were compared to serum concentrations obtained simultaneously. The penetration into bronchial secretions was rapid, maximum levels of between 1 and 5 mg/kg being already observed 1 h after injection. Most concentrations remained about 1 mg/kg throughout the whole observation period of about 5.5 h. The percent penetration amounted to about 1.5% of the corresponding serum concentrations.
  
  
  CONCLUSIONS
  Concentrations well above the MIC90s of the relevant respiratory pathogens--S. pneumoniae, M. catarrhalis, H. influenzae, K. pneumoniae--and Enterobacteriaceae were reached in bronchial secretions after intravenous injection of a single 2 g dose of cefodizime. Even higher levels may be expected in the usual condition of inflamed bronchial mucosa as found in respiratory infections.
authors.affiliation: Service de Pneumologie, Hôpital Lyon-Sud, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Pacheco
authors.forename: B
authors.initials: B
authors.lastname: Pirollet
authors.forename: B
authors.initials: B
authors.lastname: Taviot
authors.forename: B
authors.initials: B
authors.lastname: Coppere
authors.forename: M
authors.initials: M
authors.lastname: Perrin-Fayolle
authors.forename: E E
authors.initials: EE
authors.lastname: Dagrosa
authors.forename: D
authors.initials: D
authors.lastname: Damm
mesh_terms: D000328:Adult; D000368:Aged; D001980:Bronchi / Q000378:metabolism*; D001999:Bronchoscopy; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
chemical_list: D002439:Cefotaxime; C033356:cefodizime