title: The first case of equine motor neuron disease in Japan.
abstract: A 9-year-old male horse showed emaciation, weakness and trembling and was euthanatized. Histopathological examinations revealed loss, swelling and chromatolysis of motor neurons throughout the spinal ventral horns, axonal degeneration of the ventral spinal roots. Eosinophilic cytoplasmic inclusions were distributed in degenerated spinal ventral neurons. Ultrastructurally, the inclusions consisted of aggregations of granular dense material and a few vesicles. They reacted positively with polyclonal antibody against ubiquitin. The present case was diagnosed as equine motor neuron disease, which has recently been reported in North America and the United Kingdom.
authors.affiliation: Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuwamura
authors.forename: M
authors.initials: M
authors.lastname: Iwaki
authors.forename: J
authors.initials: J
authors.lastname: Yamate
authors.forename: T
authors.initials: T
authors.lastname: Kotani
authors.forename: S
authors.initials: S
authors.lastname: Sakuma
authors.forename: A
authors.initials: A
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D001284:Atrophy; D001369:Axons / Q000473:pathology / Q000648:ultrastructure; D006734:Horse Diseases; D006736:Horses; D002479:Inclusion Bodies / Q000473:pathology / Q000648:ultrastructure; D007564:Japan; D008297:Male; D008854:Microscopy, Electron; D016472:Motor Neuron Disease / Q000473:pathology / Q000662:veterinary*; D009046:Motor Neurons / Q000473:pathology* / Q000648:ultrastructure; D009132:Muscles / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*; D014452:Ubiquitins / Q000032:analysis
chemical_list: D014452:Ubiquitins