title: Polymorphisms of complement component I and C1R subcomponent of C1 in nine aboriginal Taiwanese populations.
abstract: Complement component I (IF) and C1R subcomponent of C1 (C1R) types were determined by isoelectric focusing and subsequent immunoblotting techniques for 658 individuals from nine aboriginal Taiwanese populations. The frequency of the IF*A allele ranges from 0.075 (Bunun) to 0.430 (Saisiat), and a new variant allele IF*B2 was found to have polymorphic frequency in the Atayal. The frequency of the C1R*1 allele ranges from 0.410 (Yami) to 0.650 (Atayal), and the frequency of the C1R*2 allele ranges from 0.265 (Atayal) to 0.586 (Saisiat). The C1R*5 allele was found in five populations (Atayal, Bunun, Ami, Puyuma, Yami), and the C1R*9 allele was found in two populations (Tsou, Puyuma). The results indicate a remarkable degree of genetic variability among these populations. The variability may reflect long-term genetic and geographic isolation of each population.
authors.affiliation: Department of Forensic Medicine, Yamagata University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Umetsu
authors.forename: I
authors.initials: I
authors.lastname: Yuasa
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: C S
authors.initials: CS
authors.lastname: Sun
authors.forename: I H
authors.initials: IH
authors.lastname: Pan
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: N
authors.initials: N
authors.lastname: Saitou
authors.forename: S
authors.initials: S
authors.lastname: Horai
mesh_terms: D000483:Alleles; D003172:Complement C1 / Q000235:genetics*; D015923:Complement C1r / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D044469:Racial Groups; D013624:Taiwan
chemical_list: D003172:Complement C1; D015923:Complement C1r