The effects of simultaneous alcohol and cobalt chloride administration on the cardiovascular system of rats.
CFY male rats received drinking water which contained 10% ethyl alcohol and 5% sugar and were treated with 50 mg/kg daily doses of cobalt chloride for three weeks by gavage. Haemodynamic examinations were carried out using radioactive microspheres. Alcohol caused no significant injury of the structure of the myocardium, while cobalt chloride caused incipient multifocal myocytolysis. Blood pressure and nutritive blood flow of the heart were decreased slightly by alcohol and significantly by cobalt chloride. Alcohol additively increased the effect of cobalt chloride decreasing the nutritive blood flow of the heart. It is suggested, that hypoxia increased by dual exposure is responsible for the aggravating effect of alcohol on the myocardial injury caused by the cobalt salt.
Morvai
V
V
2nd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Szakmáry
E
E
Tátrai
E
E
Ungváry
G
G
Folly
G
G
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003035:Cobalt / Q000633:toxicity*; D000431:Ethanol / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003035:Cobalt; D000431:Ethanol; C018021:cobaltous chloride