title: [Peripheral neuropathy and mixed cryoglobulinemia: clinical, neuro- physiological and pathological signs in a group of 12 patients].
abstract: This retrospective study involved a series of 12 patients with peripheral neuropathy and mixed type III cryoglobulinemia. The predominating symptoms were sensory. In patients with essential cryoglobulinemia, neuropathy most often presented as multiple mononeuropathy, while polyneuropathic forms were most common among those with secondary cryoglobulinemia. The absence of cryosensitivity was evident in secondary forms. Both neurophysiological and morphological examination revealed a predominance of axonal neuropathy. Two cases of demyelinating neuropathy were found among those with secondary cryoglobulinemia associated with monoclonal gammopathy. Although the vascular lesion was clearly demonstrable in muscle and skin tissue, this was not so in the nervous system.
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario, Zaragoza.
authors.forename: P
authors.initials: P
authors.lastname: Larrodé
authors.forename: S
authors.initials: S
authors.lastname: Ramón Cajal
authors.forename: M
authors.initials: M
authors.lastname: Domínguez
authors.forename: F
authors.initials: F
authors.lastname: Morales
authors.forename: J
authors.initials: J
authors.lastname: Marta
authors.forename: S
authors.initials: S
authors.lastname: Sánchez
authors.forename: J A
authors.initials: JA
authors.lastname: Mauri
authors.forename: S
authors.initials: S
authors.lastname: Adelantado
mesh_terms: D000328:Adult; D000368:Aged; D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D003449:Cryoglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Neuropatía periférica y crioglobulinemia mixta: aspectos clínicos, neurofisiológicos y patológicos en una serie de 12 pacientes.