title: The systolic blood pressure variation as an indicator of pulmonary capillary wedge pressure in ventilated patients.
abstract: Animal data have suggested that the systolic pressure variation (SPV) noted during positive pressure ventilation may be a sensitive indicator of hypovolaemia. The aim of this study was to correlate the SPV with the pulmonary capillary wedge pressure (PCWP) in a heterogeneous group of ICU patients on volume-cycled ventilation. Three hundred data sets were collected on 226 patients. The correlation coefficient between the SPV and PCWP for the first half of the data set was -0.84 (P < 0.001). The linear regression formula from this data set was: PCWP = 20-(SPV*0.7). Using this formula the predicted PCWP was then correlated with the measured PCWP using the second half of the data base. The correlation coefficient was 0.87 (P < 0.001). The correlation coefficient between the SPV and PCWP for the entire data base (300 observations) was -0.86 (P < 0.001). It is concluded that analysis of the arterial pressure tracing may be useful in estimating the pulmonary capillary wedge pressure in ventilated patients.
authors.affiliation: Baragwanath Hospital ICU, Soweto, South Africa.
authors.forename: P E
authors.initials: PE
authors.lastname: Marik
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002407:Catheterization, Swan-Ganz / Q000379:methods; D006801:Humans; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012121:Respiration, Artificial