[The effect of psychotropic preparations on the behavioral and hormonal manifestations of emotional stress in monkeys].
Ethological and radioimmunological techniques were used to examine the effects of psychotropic agents on the behaviour of the male Papio hamadryas and the hormonal activity of the steroid-producing glands at physiological rest and during emotional stress. Prior (15 minutes before immobilization) intramuscular administration of haloperidol, 0.1 mg/kg, amitriptyline, 2.0 mg/kg or diazepam, 0.76 mg/kg, was demonstrated to produce no stress protective effect, but to result in predominant effects of these drugs in the poststress period, or even in enhanced stress-induced behavioral and hormonal changes.
Dinzburg
A L
AL
Chirkov
A M
AM
Chirkova
S K
SK
D000208:Acute Disease; D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010215:Papio; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012149:Restraint, Physical; D012919:Social Behavior; D013315:Stress, Psychological / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood*
D011619:Psychotropic Drugs; D000639:Amitriptyline; D013739:Testosterone; D006220:Haloperidol; D003975:Diazepam; D006854:Hydrocortisone
Vliianie psikhotropnykh preparatov na povedencheskie i gormonal'nye proiavleniia émotsional'nogo stressa u obez'ian.