The toxicity of chlorophenols in V79 Chinese hamster cells.
The toxicity of nine chlorophenols to V79 Chinese hamster cells was determined in a survival assay which gives a direct measure of reproductive cell death by measuring single-cell cloning efficiency. Quantitative analyses of the structure-activity relationships showed that the toxicity was linearly related not only to hydrophobicity, as suggested by previous mammalian-cell studies, but also to electronic (electron-withdrawing) substituent effects. The extent electronic factors were related to the toxicity was assessed apart from their influence on partition and transport. The results suggest a relationship between the toxicity and the well-known ability of chlorophenols to induce proton permeability in membranes.
Jansson
K
K
Department of Cell Biology, University of Jyväkylä, Finland.
Jansson
V
V
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002733:Chlorophenols / Q000633:toxicity*; D006224:Cricetinae; D012995:Solubility; D013329:Structure-Activity Relationship
D002733:Chlorophenols