title: Biliary excretion of the mycotoxin fumonisin B1 in rats.
abstract: The biliary excretion of the mycotoxin fumonisin B1 (FB1), produced by the fungus Fusarium moniliforme Sheldon, has been measured in male Wistar rats. After ip injection of a solution of FB1 (7.5 mg/kg body weight), 67% of the applied dose was recovered in bile over a 24-hr period, 88% of this recovery being excreted in the first 4 hr after dosing. In contrast to these results, a similar dose of FB1 given by gavage resulted in only 0.2% recovery of the toxin in bile over a 24-hr period. Hence, although these results show that biliary excretion is a major route of elimination of FB1 from the circulation, only small amounts of the toxin appeared to be absorbed from the gut in rats.
authors.affiliation: Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa.
authors.forename: G S
authors.initials: GS
authors.lastname: Shephard
authors.forename: P G
authors.initials: PG
authors.lastname: Thiel
authors.forename: E W
authors.initials: EW
authors.lastname: Sydenham
authors.forename: J F
authors.initials: JF
authors.lastname: Alberts
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D037341:Fumonisins; D008297:Male; D009183:Mycotoxins / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012588:Scintillation Counting
chemical_list: D002250:Carbon Radioisotopes; D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1