[Changes in the drug-metabolizing function of the liver in chronic exposure of the body to low doses of ionizing radiation].
When receiving sanatory treatment in Odessa persons residing at the areas with strict radioecological control (Chernigov, Zhitomir, Kiev Provinces) revealed deterioration of drug metabolism in liver. Experimental data indicated as well suppression of the microsomal drug-metabolizing system of liver caused by long-term exposure of the body to low-dose ionizing radiation. The results obtained should be taken into consideration in such patients for the slowed down drug metabolism in liver may provoke side effects.
Zolotareva
T A
TA
Bondarchuk
G F
GF
Nikolaeva
T N
TN
D000328:Adult; D000632:Aminopyrine / Q000493:pharmacokinetics*; D000814:Aniline Compounds / Q000493:pharmacokinetics*; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005767:Gastrointestinal Diseases / Q000201:enzymology; D006801:Humans; D008658:Inactivation, Metabolic / Q000528:radiation effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000528:radiation effects*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014455:Ukraine
D000814:Aniline Compounds; D000632:Aminopyrine; C023650:aniline
Izmenenie farmakometaboliziruiushcheĭ funktsii pecheni pri khronicheskom vozdeĭstvii na organizm malykh doz ioniziruiushchego izlucheniia.