Free-radical activity after primary coronary angioplasty in acute myocardial infarction.
Free-radical activity in coronary venous outflow was assessed before and after reperfusion in nine patients with acute infarction who had undergone successful recanalization of the infarct-related artery by primary coronary angioplasty. Free-radical activity was measured in serum samples from coronary venous outflow over a timed period of 24 hours by using (1) the percentage molar ratio (PMR) of the diene conjugate 9,11-linoleic acid, and (2) malonaldehyde concentration. Preangioplasty PMR means lay within the normal range, but showed a marked increase soon after successful recanalization. Relative to baseline, the changes over time reached statistical significance between 2 and 60 minutes. No statistically significant changes in malonaldehyde occurred over the study period. We conclude that successful recanalization of the infarct artery is associated with significantly elevated free-radical activity, as measured by the PMR of conjugated diene, in coronary venous outflow. Such patients may be at risk from free radical mediated reperfusion injury.
Grech
E D
ED
Department of Cardiology, Cardiothoracic Centre, Liverpool, England.
Bellamy
C M
CM
Jackson
M J
MJ
Muirhead
R A
RA
Faragher
E B
EB
Ramsdale
D R
DR
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003331:Coronary Vessels; D005260:Female; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D016013:Likelihood Functions; D008041:Linoleic Acids / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000628:therapy*; D013997:Time Factors
D005609:Free Radicals; D008041:Linoleic Acids; D008054:Lipid Peroxides; D008315:Malondialdehyde