title: Transfer of gas from the acinus during continuous flow and intermittent positive pressure ventilation.
abstract: We used a technique of measuring Xenon133 washout (XeW) from the alveolar space to evaluate transfer of gas from the acinus (Mackenzie et al., J. Appl. Physiol. 68: 2013-2018, 1990) during 2 min of apnea, 2 min of tracheal insufflation with oxygen (TRIO) and 90 sec of intermittent positive pressure ventilation (IPPV) in 6 anesthetized and paralyzed dogs. Xenon133 dissolved in saline was injected into an occluded acinar region through a pulmonary artery catheter, and XeW was measured by gamma scintillation scanning. With this technique, XeW during apnea represents the contribution of cardiogenic oscillations in regional flow. The XeW rate constant (min-1 +/- SE) was 0.37 +/- 0.03 during apnea. This was not different (P > 0.05) with TRIO (0.29 +/- 0.04). With IPPV, the rate constant increased to 3.49 +/- 0.39, faster than with either apnea or TRIO (P < 0.001). We conclude that: (1) TRIO does not increase convective gas transfer from the acini compared to apnea; and (2) transfer of gas out of the acini due to cardiogenic oscillations is a very small portion of the total gas eliminated during IPPV.
authors.affiliation: Department of Anesthesiology, University of Maryland, Baltimore 21201.
authors.forename: F C
authors.initials: FC
authors.lastname: Forrest
authors.forename: P B
authors.initials: PB
authors.lastname: Randalls
authors.forename: G M
authors.initials: GM
authors.lastname: Barnas
authors.forename: B H
authors.initials: BH
authors.lastname: Hoff
authors.forename: J
authors.initials: J
authors.lastname: Oletsky
authors.forename: C F
authors.initials: CF
authors.lastname: Mackenzie
mesh_terms: D000818:Animals; D001049:Apnea / Q000503:physiopathology; D001692:Biological Transport / Q000502:physiology; D004285:Dogs; D015902:Gamma Cameras; D007385:Intermittent Positive-Pressure Ventilation; D010100:Oxygen / Q000493:pharmacokinetics; D011650:Pulmonary Alveoli / Q000502:physiology*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D014978:Xenon / Q000493:pharmacokinetics*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D014978:Xenon; D010100:Oxygen