title: Clinical assessment of gingival hyperplasia in patients treated with nifedipine.
abstract: Gingival hyperplasia caused by the use of nifedipine has been extensively reported. In this paper, the gingiva of 18 patients suffering from cardiopathy and treated with nifedipine were compared with those of 10 patients with cardiac disorders who had not been treated with calcium antagonists and with a no-treatment group of 12 patients. Nifedipine produced gingival hyperplasia, although patients who had not been treated with calcium antagonists also had mild hyperplasia. Hyperplasia first appeared in the interproximal areas, an observation which may be important for early detection. There was a direct correlation between the degree of hyperplasia and the bacterial plaque score. When we studied the influence of administration time and dose of nifedipine with the degree of hyperplasia, no statistically significant differences were found.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Seville, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Bullon
authors.forename: G
authors.initials: G
authors.lastname: Machuca
authors.forename: A
authors.initials: A
authors.lastname: Martinez-Sahuquillo
authors.forename: J V
authors.initials: JV
authors.lastname: Rios
authors.forename: J
authors.initials: J
authors.lastname: Rojas
authors.forename: J R
authors.initials: JR
authors.lastname: Lacalle
mesh_terms: D003774:Dental Plaque Index; D004305:Dose-Response Relationship, Drug; D005260:Female; D005884:Gingival Hemorrhage / Q000139:chemically induced / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects*; D009910:Oral Hygiene; D013997:Time Factors
chemical_list: D009543:Nifedipine