title: Morphologic effects of a sulfur(IV) aerosol on the nasal cavity of beagle dogs.
abstract: Morphologic changes were observed in nasal cavities of beagle dogs after long-term exposure to a respirable sulfur(IV) aerosol at a concentration equivalent to a sulfur dioxide (SO2) concentration of 0.6 mg/m3. The changes were characterized by a thickened epithelial layer resulting from epithelial proliferation, by a loss of secretory material, and by moderate mononuclear cell infiltration.
authors.affiliation: GSF-Forschungszentrum für Umwelt und Gesundheit Neuherberg, Projekt Inhalation, Oberschleissheim, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Takenaka
authors.forename: G
authors.initials: G
authors.lastname: Fürst
authors.forename: P
authors.initials: P
authors.lastname: Heilmann
authors.forename: A
authors.initials: A
authors.lastname: Heini
authors.forename: U
authors.initials: U
authors.lastname: Heinzmann
authors.forename: E
authors.initials: E
authors.lastname: Karg
authors.forename: A B
authors.initials: AB
authors.lastname: Murray
authors.forename: L
authors.initials: L
authors.lastname: Ruprecht
authors.forename: J
authors.initials: J
authors.lastname: Heyder
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D004285:Dogs; D008297:Male; D009296:Nasal Cavity / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*; D010084:Oxidation-Reduction; D013455:Sulfur / Q000737:chemistry / Q000633:toxicity*; D013458:Sulfur Dioxide / Q000737:chemistry / Q000633:toxicity; D013461:Sulfur Oxides / Q000737:chemistry / Q000633:toxicity; D013997:Time Factors
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D013461:Sulfur Oxides; D013458:Sulfur Dioxide; D013455:Sulfur