title: Efficacy and tolerability of brodimoprim in bacterial otitis media in children. Controlled study versus cefaclor.
abstract: 78 pediatric patients affected by acute otitis media were selected and randomized into two balanced groups of treatment: brodimoprim, at the dosage of 200 mg once-a-day on the first day and of 100 mg once-a-day on the following days, and cefaclor at a dosage of 40 mg/Kg/day in three doses. Brodimoprim resulted more efficacious in the reduction of symptoms, especially hypoacusis and tinnitus (p < 0.05 between treatments); tympanometry showed a higher number of normalizations in the brodimoprim group, without significant differences between treatments. Both drugs resulted active against most of isolated bacterial strains. Side effects were reported in 4 patients treated with brodimoprim and in 6 patients in the control group.
authors.affiliation: Clinica O.R.L., Università di Modena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Galetti
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: G
authors.initials: G
authors.lastname: Bergamini
authors.forename: S
authors.initials: S
authors.lastname: Dallari
authors.forename: A
authors.initials: A
authors.lastname: Ghidini
authors.forename: M
authors.initials: M
authors.lastname: Mazzoli
authors.forename: L
authors.initials: L
authors.lastname: Cantini
authors.forename: P A
authors.initials: PA
authors.lastname: Monici Preti
mesh_terms: D000208:Acute Disease; D001424:Bacterial Infections; D002433:Cefaclor / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*; D010034:Otitis Media with Effusion / Q000188:drug therapy; D014295:Trimethoprim / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D002433:Cefaclor; D014295:Trimethoprim; C037079:brodimoprim