Altered levels of histone H1(0) and DNA topoisomerase activity in the liver of the tumour-bearing rat.
Walker 256 carcinoma cells were injected subcutaneously into the dorsal region of rats. After 9 days of tumour growth increases were observed in liver mass and DNA content and in the incorporation of [3H]-thymidine into liver DNA. These changes were accompanied by a fall in the H1(0) fraction of liver histones and rises in both DNA topoisomerase I and II activities.
Goodlad
G A
GA
School of Biological and Medical Sciences, Division of Cell and Molecular Biology, University of St. Andrews, Fife, Scotland, U.K.
Clark
C M
CM
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D004247:DNA / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006657:Histones / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D009690:Nucleic Acid Conformation; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured
D006657:Histones; D004247:DNA; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II