title: Medical management of colorectal carcinomas.
abstract: Current information on the medical treatment of colorectal cancer was reviewed after a search of the literature through Medline. Publications from 1984 to present were surveyed. Appropriate adjuvant therapy increases overall survival and disease-free intervals. The treatment modalities of unresectable or metastatic tumors are disappointing, with at best 40% of patients experiencing short-lasting responses. Whenever possible, patients with advanced colorectal cancer should be enrolled in clinical trials.
authors.affiliation: Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
authors.forename: C F
authors.initials: CF
authors.lastname: Verschraegen
authors.forename: R
authors.initials: R
authors.lastname: Pazdur
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D015337:Multicenter Studies as Topic