The effect of diclofenac and ketoprofen on halothane MAC in rabbit.
Non-steroidal anti-inflammatory drugs obviously act also on the central nervous system. We, therefore, studied the effect of diclofenac 3 mg/kg and ketoprofen 4 mg/kg on the minimum alveolar concentration (MAC) of halothane in 10 New Zealand White rabbits. After determination of halothane MAC, total doses of NSAIDs were administered intravenously as three subdoses: 12.5%, 37.5% and 50% of the total dose. Depth of anaesthesia did not increase significantly after the first two doses with either drug. With ketoprofen, halothane MAC increased after subdose 3 from 1.52 (SD 0.42) vol% to 1.9 (SD 0.36) vol% (p < 0.01). With diclofenac, halothane MAC increased after subdose 3 from 1.44 (SD 0.18) vol% to 1.60 (SD 0.39) vol% (ns). With both drugs, large interindividual differences of MAC appeared after full doses of NSAIDs.
Rorarius
M G
MG
Department of Anaesthesiology, Tampere University Hospital, Finland.
Baer
G A
GA
Metsä-Ketelä
T
T
D000769:Anesthesia, Inhalation; D000818:Animals; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006221:Halothane / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation
D004008:Diclofenac; D007660:Ketoprofen; D006221:Halothane