title: [CSF-1 (colony stimulating factors 1) and CSF-1 receptor. General review and expression in invasive breast tumors].
abstract: CSF-1 (colony stimulating factor-1), initially considered to be a monocyte specific growth and differentiation factor [4], has recently been shown to be produced in human endometrium [16], placenta [7], as well as in numerous solid tumors [19-23, 26, 27]. The CSF-1 receptor (a protein product of c-fms) [24] is a member of the tyrosine kinase receptor family and an autocrine or paracrine mechanism of activation has been suggested. Overactivation of this receptor can lead to a malignant phenotype in various cell systems [20, 21]. We review the biology of CSF-1 and fms expression in normal as well as in malignant tissues with particular reference to a potential role for CSF-1 in breast tumour invasion.
authors.affiliation: Laboratoire d'anatomopathologie, hôpital Sainte-Anne, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Beuvon
authors.forename: C
authors.initials: C
authors.lastname: Palud
authors.forename: R
authors.initials: R
authors.lastname: Tang
authors.forename: A
authors.initials: A
authors.lastname: de la Rochefordière
authors.forename: S
authors.initials: S
authors.lastname: Kheirallah
authors.forename: P
authors.initials: P
authors.lastname: Pouillart
authors.forename: S M
authors.initials: SM
authors.lastname: Scholl
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D003115:Colony-Stimulating Factors / Q000502:physiology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D016184:Receptors, Colony-Stimulating Factor / Q000502:physiology*
chemical_list: D003115:Colony-Stimulating Factors; D016184:Receptors, Colony-Stimulating Factor
vernacular_title: CSF-1 (colony stimulating factor 1) et récepteur du CSF-1. Revue générale et expression dans les tumeurs mammaires invasives.