Long-term cerebral effects of CNS chemotherapy in children with acute lymphoblastic leukemia.
Fifteen 7-16-year-old patients, treated in 1981-1984 for acute lymphoblastic leukemia (ALL) in first complete remission, were studied. As a central nervous system prophylaxis, all the children were treated with repeated methotrexate (MTX) instillations, but none were irradiated. The study protocol included magnetic resonance (MR) and a battery of neuropsychological tests. Small, punctate white-matter lesions were found by MR in eight children, probably minor vascular lesions. All the children were within normal intelligence range with a mean total WISC-R IQ of 109. Minor neuropsychologic problems were found in two patients, while one child showed a more extensive specific learning disorder in school.
Bakke
S J
SJ
Department of Diagnostic Radiology, National Hospital, University of Oslo, Norway.
Fossen
A
A
Storm-Mathiesen
I
I
Lie
S O
SO
D000293:Adolescent; D001284:Atrophy; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal / Q000009:adverse effects; D007859:Learning Disabilities / Q000139:chemically induced / Q000150:complications; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009483:Neuropsychological Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D017741:Survivors / Q000523:psychology; D014057:Tomography, X-Ray Computed
D008727:Methotrexate