title: A field evaluation of the efficacy of tolfenamic acid and oxytetracycline in the treatment of bovine respiratory disease.
abstract: In a blinded multicentre trial 313 cattle showing clinical signs of respiratory disease were allocated randomly into three groups, treated intramuscularly with a long-acting oxytetracycline formulation at a dose rate of 20 mg/kg bodyweight in combination with vehicle alone (placebo) or with tolfenamic acid at 2 mg/kg bodyweight once or on two occasions with a 48-h interdosing interval. The clinical status of the animals was monitored for 5 days using a specific scoring system and weight gain was calculated between day 0 and day 21. Relapses were monitored from day 5 until day 21. When oxytetracycline was combined with two injections of tolfenamic acid, there was a significant (P < 0.04) improvement in the clinical resolution. This regimen also produced non-significant improvements in cure rate, reduced frequency of relapses and improved weight gain.
authors.affiliation: VETOQUINOL Research Center, Lure, France.
authors.forename: J
authors.initials: J
authors.lastname: Deleforge
authors.forename: E
authors.initials: E
authors.lastname: Thomas
authors.forename: J L
authors.initials: JL
authors.lastname: Davot
authors.forename: B
authors.initials: B
authors.lastname: Boisrame
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D011016:Pneumonia, Atypical Interstitial, of Cattle / Q000188:drug therapy; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D062367:ortho-Aminobenzoates; C009500:tolfenamic acid; D010118:Oxytetracycline