title: [Basedow-Graves disease development in 2 patients with primary hypothyroidism: exceptional development of the autoimmune thyroid disease].
abstract: Autoimmune thyroid disease has multiple manifestations and its presentation may change with time. We report two patients with primary hypothyroidism due to Hashimoto's disease that unexpectedly, developed a hyperthyroidism due to Basedow-Graves disease. This phenomenon may be explained by variations in the types and proportions of anti TSH receptor antibodies, that can stimulate or block thyroid gland function and growth. It is deducted that the hypothyroidism of these patients was not due to a definitive gland destruction, but to the action of function blocking antibodies.
authors.affiliation: Departamento de Endocrinología, Mebabolismo y Nutrición, Escuela de Medicina, P Universidad Católica de Chile, Santiago de Chile.
authors.forename: E
authors.initials: E
authors.lastname: Arteaga
authors.forename: C
authors.initials: C
authors.lastname: Campusano
authors.forename: P
authors.initials: P
authors.lastname: Michaud
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology; D007037:Hypothyroidism / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000008:administration & dosage; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D011441:Propylthiouracil; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Desarrollo de enfermedad de Basedow-Graves en 2 pacientes con hipotiroidismo primario. Evolución excepcional de la enfermedad tiroídea autoinmune.