Parvovirus B19-associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia.
A 36-year-old man who had been treated for Evans syndrome (ES) developed an aplastic crisis caused by acute human parvovirus B19 (HPV) infection. Profound thrombocytopenia (8.0 x 10(9)/l) followed with a sudden increase in platelet-associated IgG (PAIgG) (1376.9 ng/10(7) plts). Bone marrow examination revealed a considerable number of haemophagocytic histiocytes without any disturbance of megakaryopoiesis. To our knowledge this is the first case of aplastic crisis with virus-associated haemophagocytosis in a patient with ES, which provides an interesting insight into the mechanisms for thrombocytopenia in HPV infection.
Uike
N
N
Department of Haematology, National Kyushu Cancer Centre, Fukuoka, Japan.
Miyamura
T
T
Obama
K
K
Takahira
H
H
Sato
H
H
Kozuru
M
M
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000150:complications*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016732:Parvovirus B19, Human; D013921:Thrombocytopenia / Q000209:etiology*
D004279:DNA, Viral