Effect of dihydroergocryptine on serum prolactin levels and milk secretion in puerperal women.
The aim of the present study was to evaluate the efficacy and tolerability of the dopamine agonist drug dihydroergocryptine in the suppression of puerperal lactation. A single blind and placebo-controlled study was performed. A total of 90 postpartum women was acutely or repeatedly treated with dihydroergocryptine at different doses in order to investigate the efficacy of this drug in the suppression of puerperal lactation and to find the optimum dose for therapy. Prolactin levels, mammary symptomatology and rebound effects were monitored during the repeated treatment and also 1 and 8 days after drug discontinuation. With acute administration, dihydroergocryptine significantly reduced prolactin levels only at the dose of 10 mg and not at 5 mg. With repeated administration, a daily dose of 15 mg was more effective than 10 mg in reducing prolactin levels and in suppressing puerperal lactation. No side-effects occurred during the treatment. These results suggest that dihydroergocryptine might be considered an effective drug in the suppression of puerperal lactation.
Nappi
C
C
Department of Gynecological Endocrinology, School of Medicine, University of Turin, Italy.
Colace
G
G
Di Carlo
C
C
Affinito
P
P
Ruotolo
C
C
Montemagno
R
R
Farace
M J
MJ
Mailland
F
F
Di Renzo
G F
GF
D000284:Administration, Oral; D000328:Adult; D004088:Dihydroergotoxine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007774:Lactation / Q000097:blood / Q000187:drug effects*; D049590:Postpartum Period / Q000187:drug effects*; D011388:Prolactin / Q000097:blood*; D011863:Radioimmunoassay; D016037:Single-Blind Method
D004088:Dihydroergotoxine; D011388:Prolactin