Microwave balloon angioplasty effectively seals arterial dissections in an atherosclerotic rabbit model.
OBJECTIVE
The purpose of this study was to determine the effectiveness of microwave balloon angioplasty in sealing arterial dissections and to characterize the histologic features associated with this intervention.


BACKGROUND
Coronary dissection accompanying balloon dilation is frequently associated with abrupt closure and acute ischemic complications. Effective management of this complication remains an active area of investigation. Because thermal energy is effective in welding separated atherosclerotic plaques, a microwave-based catheter system that provides controlled local heating was utilized in vessels with angioplasty-induced dissections.


METHODS
Iliac artery dissections were induced in ahypercholesterolemic rabbit model. Vessels were randomly assigned to treatment with standard balloon angioplasty (control vessels) or microwave balloon angioplasty using an average temperature of 80 degrees C. The response of the artery was assessed angiographically and histologically.


RESULTS
Angiographic success, defined as a reduction of dissection length by > 50% or the resolution of lumen haziness, was achieved in 63% of microwave-treated vessels and in 16% of control vessels (p < 0.005). Dissection length (mean +/- SD) was reduced 8.0 +/- 4.8 mm in microwave-treated vessels compared with 0.1 +/- 7.9 mm in vessels receiving standard balloon inflations (p < 0.005). Cellular necrosis was more commonly observed in microwave-treated vessels than in control vessels (73% vs. 17%, p < 0.05), but less intraluminal thrombus was seen in vessels exposed to microwave energy (p < 0.05).


CONCLUSIONS
Microwave balloon angioplasty is more effective than routine balloon inflations in sealing arterial dissections in this model and appears to be less thrombogenic in these markedly disrupted vessels.
Landau
C
C
Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts.
Currier
J W
JW
Haudenschild
C C
CC
Minihan
A C
AC
Heymann
D
D
Faxon
D P
DP
D000792:Angiography; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000379:methods*; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D016342:Angioplasty, Laser; D000818:Animals; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D007083:Iliac Artery; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D011817:Rabbits