Changes of pineal N-acetyltransferase activity in gamma irradiated rats.
Male Wistar rats were exposed to whole body irradiation with 14.35 Gy gamma rays after the adaptation to light/dark cycle (LD 12:12). Three groups of rats were examined: A) rats irradiated in the night and placed in the 12 h LD cycle again, B) rats irradiated in the day-time and placed in the 12 h LD cycle, and C) rats irradiated in the night and kept in constant darkness. All analyses were carried out in the dark. Radiation enhanced the activity of pineal N-acetyltransferase 3-4 days after exposure in all groups, in the C group significantly on the 4th day. Different light regimens during and after irradiation did not to affect the activity of this key enzyme of melatonin synthesis substantially.
Kassayová
M
M
Institute of Animal Physiology, Faculty of Science, Safárik University, Kosice, Slovak Republic.
Ahlersová
E
E
Ahlers
I
I
D000123:Acetyltransferases / Q000378:metabolism* / Q000528:radiation effects*; D000818:Animals; D002940:Circadian Rhythm; D005720:Gamma Rays; D008297:Male; D008550:Melatonin / Q000378:metabolism; D010870:Pineal Gland / Q000201:enzymology* / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D014916:Whole-Body Irradiation
D000123:Acetyltransferases; D008550:Melatonin