title: Ultrasound-guided fine-needle aspiration biopsy in the management of thyroid disease.
abstract: During a 23-month period, 59 patients were referred for ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) of the thyroid gland because of inadequate orthodox (office) FNAB, a clinically small lesion, or an occult lesion. Seventy percent of the group (41 patients) was referred for surgery, which revealed cancer in 37% of patients, adenoma in 19%, and benign disease in 44%. US-guided FNAB yielded false-positive reports in 0% of patients, false-negative reports in 5% to 12%, and inadequate aspirates in 32%. The US-guided FNAB technique had a sensitivity of 60% to 90%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 80%, and an accuracy of 85%. US-guided FNAB provides cytologic information in 60% of patients in whom a diagnosis cannot be established by orthodox (office) means, thus enhancing the diagnostic ability of clinicians who can recommend a treatment program with confidence.
authors.affiliation: Department of Surgery, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
authors.forename: I B
authors.initials: IB
authors.lastname: Rosen
authors.forename: A
authors.initials: A
authors.lastname: Azadian
authors.forename: P G
authors.initials: PG
authors.lastname: Walfish
authors.forename: S
authors.initials: S
authors.lastname: Salem
authors.forename: E
authors.initials: E
authors.lastname: Lansdown
authors.forename: Y C
authors.initials: YC
authors.lastname: Bedard
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D001707:Biopsy, Needle / Q000379:methods*; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D012680:Sensitivity and Specificity; D013959:Thyroid Diseases / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D016606:Thyroid Nodule / Q000175:diagnosis; D013966:Thyroiditis / Q000175:diagnosis; D014463:Ultrasonography