Regulation and function of the Rho subfamily of small GTPases.
During the past year, the small GTP-binding proteins Rho and Rac have each been shown to regulate a signal transduction pathway linking growth factor receptors to distinct changes in the actin cytoskeleton. A number of regulatory molecules for Rho-like proteins have been identified and some of these may cross-talk with the Ras signalling pathway.
Nobes
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MRC Laboratory for Molecular Cell Biology, University College London, UK.
Hall
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D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D020690:GTPase-Activating Proteins; D020730:Guanine Nucleotide Dissociation Inhibitors; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D020744:rac GTP-Binding Proteins; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
D020690:GTPase-Activating Proteins; D020730:Guanine Nucleotide Dissociation Inhibitors; C085379:rho GTPase-activating protein; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins