Abnormal platelet mitochondrial function in patients affected by migraine with and without aura.
To investigate energy metabolism in migraine, we determined platelet mitochondrial enzyme activities in 40 patients with migraine with aura and in 40 patients with migraine without aura during attack-free intervals and in 24 healthy control subjects. NADH-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities in both patient groups were significantly lower than in controls (p < 0.01), while NADH-cytochrome-c-reductase activity was reduced only in migraine with aura (p < 0.01). No alteration in succinate-dehydrogenase was observed. Monoamine-oxidase activity differed between sexes (p < 0.05) but within each sex group no difference was observed between patients and controls. We hypothesize that the defect in mitochondrial enzymes observed indicates a systemic impairment of mitochondrial function in migraine patients.
Sangiorgi
S
S
Institute of Neurology, University of Bologna, Italy.
Mochi
M
M
Riva
R
R
Cortelli
P
P
Monari
L
L
Pierangeli
G
G
Montagna
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology / Q000502:physiology*; D002950:Citrate (si)-Synthase / Q000097:blood / Q000172:deficiency*; D030401:Cytochrome-c Oxidase Deficiency; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000097:blood; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000145:classification; D008928:Mitochondria / Q000201:enzymology / Q000502:physiology*; D008995:Monoamine Oxidase / Q000097:blood; D009245:NADH Dehydrogenase / Q000097:blood / Q000172:deficiency*; D013385:Succinate Dehydrogenase / Q000097:blood
D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D002950:Citrate (si)-Synthase