title: Monoclonal antibodies directed against surface and intracellular antigens of mouse granulated metrial gland cells.
abstract: Rat monoclonal antibodies with reactivity directed against mouse GMG cells have been produced. One of the antibodies (GMG-1) reacts with a surface antigen of GMG cells and cross-reacts with T lymphocytes. Another (GMG-2) reacts with an intracellular antigen in GMG cells and with asialo-GM1 positive cells in the spleen. Three antibodies (GMG-3, -4, -5) bind to intracellular antigens in GMG cells. The cross-reactivity of these antibodies is discussed with reference to the lineage relationship of GMG cells to NK cells and T cells and the recent suggestion that NK cells and T cells have a common progenitor cell. It is proposed that GMG cells share this common progenitor cell but are otherwise independent of the NK or T cell lineages.
authors.affiliation: Faculty of Medicine, School of Biological Sciences, University of Southampton, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Stewart
authors.forename: D D
authors.initials: DD
authors.lastname: Mukhtar
authors.forename: A M
authors.initials: AM
authors.lastname: Sawyer
authors.forename: A E
authors.initials: AE
authors.lastname: Wild
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000276:immunology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D003593:Cytoplasm / Q000276:immunology*; D005260:Female; D006825:Hybridomas; D007132:Immunoglobulin Isotypes; D007150:Immunohistochemistry; D008297:Male; D008791:Metrial Gland / Q000166:cytology* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007132:Immunoglobulin Isotypes