title: Reverse interpretation: a hypothetical selection mechanism for adaptive mutagenesis based on autoregulated mRNA stability.
abstract: The problem of adaptive mutagenesis is examined under the assumption that selection occurs through the interaction of cognate mRNA and protein molecules, a phenomenon that has been considered to lead to differential mRNA decay (Kyrpides & Ouzounis, 1993, J. theor. Biol. 163, 373-392). Based on the stereochemical hypothesis, we speculate that the origin of this process relies on an extended form of molecular interactions. This mechanism, termed reverse interpretation, predicts the selective amplification of successful molecular forms with the capability of their immortalization through reverse transcription, in a manner that resembles, but is not equivalent to, reverse translation. Finally, we argue that the proposed mechanism conforms with the Darwinian view of evolutionary change, if variability is considered to be a property of molecular and not cellular populations.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: C A
authors.initials: CA
authors.lastname: Ouzounis
authors.forename: N C
authors.initials: NC
authors.lastname: Kyrpides
mesh_terms: D000818:Animals; D005075:Biological Evolution; D008957:Models, Genetic; D016296:Mutagenesis / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*; D012641:Selection, Genetic; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D011506:Proteins; D012333:RNA, Messenger