title: Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf).
abstract: This study evaluated the feasibility of using 99mTc-pentetic acid (DTPA) as a radioactive tracer for aerosolized synthetic surfactant (DPPC, cetyl alcohol, tyloxapol). The 99mTc-DTPA was admixed with surfactant and aerosolized using a nebulizer system interfaced to a ventilator with a cascade impactor attached to the endotracheal tube. Particle size distribution for DPPC, cetyl alcohol, and 99mTc-DTPA were almost identical during the 0- to 15-, 15- to 30-, and 0- to 30-min collection periods. Tyloxapol exhibited a unique distribution pattern with increased deposition in large (> 10 microns) and small (0.65 to 1.1 microns) particles. The mass median aerodynamic diameter for all aerosolized components was in the respirable range of 2.1 to 2.5 microns. A mixture of 99mTc-DTPA with synthetic surfactant appears to be a reasonable method to evaluate surfactant deposition.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710.
authors.forename: R E
authors.initials: RE
authors.lastname: Coleman
authors.forename: N
authors.initials: N
authors.lastname: MacIntyre
authors.forename: G
authors.initials: G
authors.lastname: Snyder
authors.forename: E
authors.initials: E
authors.lastname: Pattishall
authors.forename: D
authors.initials: D
authors.lastname: Zaccardelli
mesh_terms: D000336:Aerosols; D002855:Chromatography, Thin Layer; D004338:Drug Combinations; D005233:Fatty Alcohols / Q000008:administration & dosage; D005240:Feasibility Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008961:Models, Structural; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D010767:Phosphorylcholine; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011663:Pulmonary Surfactants / Q000008:administration & dosage; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate; D012122:Ventilators, Mechanical
chemical_list: D000336:Aerosols; D004338:Drug Combinations; D005233:Fatty Alcohols; D011663:Pulmonary Surfactants; D010767:Phosphorylcholine; D011092:Polyethylene Glycols; C047049:dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination; D016284:Technetium Tc 99m Pentetate