[The production of IL-1, IL-3 and CSA by bone marrow nuclear elements during the recovery of bone marrow hematopoiesis after lethal irradiation and the transplantation of syngeneic bone marrow].
The production of haemopoietic factors (IL-1, IL-3, CSA) by adherent and nonadherent cells of lethally irradiated CBA mice bone marrow and after syngenic myelokaryocyte transplantation was studied. Radioresistant myelokaryocytes capable to produce haemopoietic factors IL-1, CSA as early as 24 hr after irradiation were found in adherent cell fraction. The synthesis of humoral factors (IL-3, CSA) by nonadherent bone marrow elements was realised in a late terms of experiment (3-6 days) that was connected with forming of functionally valuable cell forms from transplanted or viable stem cells.
Dygaĭ
A M
AM
Buznik
D V
DV
Bogdashin
I V
IV
Agafonov
V I
VI
D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000276:immunology; D002448:Cell Adhesion / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis / Q000276:immunology / Q000528:radiation effects*; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis / Q000528:radiation effects*; D007377:Interleukin-3 / Q000032:analysis / Q000096:biosynthesis / Q000528:radiation effects*; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014185:Transplantation, Isogeneic; D014916:Whole-Body Irradiation
D007375:Interleukin-1; D007377:Interleukin-3
Produktsiia kostno-mozgovymi nuklearami IL-1, IL-3 i KSA v protsesse vosstanovleniia kostno-mozgovogo krovetvoreniia posle letal'nogo oblucheniia i transplantatsii singennogo kostnogo mozga.