Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi.
The in vitro activities of the macrolide antibiotics clarithromycin, 14-hydroxy-clarithromycin, azithromycin, and erythromycin against 19 isolates of Borrelia burgdorferi were investigated. MICs ranged from 0.003 to 0.03 microgram of clarithromycin per ml, 0.007 to 0.03 microgram of 14-hydroxyclarithromycin per ml, 0.003 to 0.03 microgram of azithromycin per ml, and 0.007 to 0.06 microgram of erythromycin per ml. Time-kill studies using the B31 strain of B. burgdorferi demonstrated a > or = 3-log10-unit killing after 72 h with each of the macrolide antibiotics tested in concentrations representing twice the respective MICs.
Dever
L L
LL
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7881.
Jorgensen
J H
JH
Barbour
A G
AG
D000818:Animals; D017963:Azithromycin / Q000494:pharmacology*; D015748:Borrelia burgdorferi Group / Q000187:drug effects*; D017291:Clarithromycin / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D051379:Mice; D008826:Microbial Sensitivity Tests; D013987:Ticks; D013997:Time Factors
D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin