title: [Angio-invasive disseminated aspergillosis: autopsy diagnosis in leukemic patients].
abstract: We report on two patients with acute lymphoblastic leukemia in induction chemotherapy, who developed a sepsis which led, in both cases, to death following the appearance of neurological symptoms suggesting CNS affectation. Autopsy revealed an angioinvasive disseminated aspergillosis affecting lungs, brain, myocardium, kidneys, thyroid glands in both cases, and endocardium, urinary bladder, lymph nodes, alimentary tract, nasal sinuses in one of the cases. Microbiology study of necropsic tissue showed Aspergillus flavusoryzae and likewise Candida albicans in one case. The latter finding suggest a combined fungal sepsis caused to candida and aspergillus.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia.
authors.forename: V
authors.initials: V
authors.lastname: Ramos Fernández
authors.forename: M
authors.initials: M
authors.lastname: Prieto Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Paradís Alós
authors.forename: F
authors.initials: F
authors.lastname: López Chulía
authors.forename: J V
authors.initials: JV
authors.lastname: Salom Fúster
authors.forename: F J
authors.initials: FJ
authors.lastname: Vera-Sempere
mesh_terms: D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis*; D001344:Autopsy; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*
vernacular_title: Aspergilosis diseminada angioinvasiva: diagnóstico necrópsico en pacientes leucósicos.