title: African swine fever virus genome content and variability.
abstract: A 55 kilobase pair (kb) region from the right end of the virulent African swine fever virus isolate, Malawi LIL20/1, has been sequenced. The 68 major open reading frames (ORFs) encoded are generally closely spaced and read from both DNA strands across the complete sequence. Comparison of the amino acid sequences of predicted ORFs with sequence databases identified 15 ORFs which encode proteins that are similar to proteins of known function. Two ORFs are homologous to copies of multigene family 360 (MGF360) and one ORF is homologous to copies of multigene family 110 (MGF110). Both of these multigene families have been described previously.
authors.affiliation: AFRC Institute for Animal Health, Pirbright, Woking, U.K.
authors.forename: L K
authors.initials: LK
authors.lastname: Dixon
authors.forename: S A
authors.initials: SA
authors.lastname: Baylis
authors.forename: S
authors.initials: S
authors.lastname: Vydelingum
authors.forename: S R
authors.initials: SR
authors.lastname: Twigg
authors.forename: J M
authors.initials: JM
authors.lastname: Hammond
authors.forename: P M
authors.initials: PM
authors.lastname: Hingamp
authors.forename: C
authors.initials: C
authors.lastname: Bristow
authors.forename: P J
authors.initials: PJ
authors.lastname: Wilkinson
authors.forename: G L
authors.initials: GL
authors.lastname: Smith
mesh_terms: D000358:African Swine Fever Virus / Q000235:genetics*; D003001:Cloning, Molecular; D014644:Genetic Variation; D016679:Genome, Viral; D005810:Multigene Family; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D021382:Protein Sorting Signals / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014763:Viral Matrix Proteins / Q000235:genetics
chemical_list: D021382:Protein Sorting Signals; D014763:Viral Matrix Proteins