Patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a psychological challenge.
Numerous physiological and biochemical factors contribute to the dynamic regulation of the cardiovascular system. This study used a cluster analytic statistical technique to discern patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a laboratory challenge. Fifty hypertensive and normotensive black and white individuals had their beta- and alpha-adrenergic receptor sensitivity determined through agonist infusions. Norepinephrine, epinephrine, blood pressure, and heart rate responses to a standardized mental arithmetic task were also obtained. The cluster analysis identified four subgroups of individuals having distinct patterns of receptor and neurohormonal regulation of end-organ responses. In general, the data indicated that end-organ cardiovascular responses are, in part determined by the sensitivity of adrenergic receptors and the accompanying catecholamine responses. The findings also suggest that for some individuals nonadrenergic factors play a more dominant role than adrenergic mechanisms in determining cardiovascular pressor responses.
Mills
P J
PJ
Department of Psychiatry, University of California, San Diego 92093.
Dimsdale
J E
JE
Nelesen
R A
RA
Jasiewicz
J
J
Ziegler
M G
MG
Kennedy
B
B
D000328:Adult; D001143:Arousal / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D004837:Epinephrine / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology*; D011340:Problem Solving / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology
D011941:Receptors, Adrenergic; D009638:Norepinephrine; D004837:Epinephrine