[The relationship between the magnitude of the negative inotropic action and chemical structure of crown-ether derivatives].
The relationship between the inotropic effect and chemical structure of 15-crown-5 and 18-crown-6 derivatives was studied in experiments in open-chest anaesthesized cats, by using computer-aided analysis. The findings showed that the 15-crown-5 derivatives produced more pronounced cardiotropic effect and they were less toxic than 18-crown-6 derivatives. Computer-aided analysis revealed pharmacophoric groups which are responsible for cardiotropic (negative inotropic) activity in the series of crown ether derivatives.
Gurbanov
K G
KG
Paperno
A A
AA
Spasov
A A
AA
Vasil'ev
P M
PM
Breslaukhov
A G
AG
Luk'ianenko
N G
NG
Basok
S S
SS
Kulygina
E Iu
EIu
Bogashchenko
T Iu
TIu
D000818:Animals; D002415:Cats; D043844:Crown Ethers; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects*; D013329:Structure-Activity Relationship
D043844:Crown Ethers; D004988:Ethers, Cyclic; C042148:15-crown-5; C015762:18-crown-6
Zavisimost' mezhdu velichinoĭ otritsatel'nogo inotropnogo deĭstviia i khimicheskoĭ strukturoĭ proizvodnykh kraun-éfirov.