Normal developmental profiles of CSF gangliotetraose-series gangliosides from neonatal period to adolescence.
The normal developmental profiles of cerebrospinal fluid (CSF) gangliosides were examined from the neonatal period to adolescence, using 1 ml of clinically available CSF, by the thin-layer chromatography/enzyme-immunostaining method. The level of total gangliotetraose-series gangliosides, including GM1, GD1a, GT1a, GD1b, GT1b, and GQ1b, increased 3.8-fold from the neonatal period to age 5 years, followed by a plateau, and then a mild decrease. The developmental profiles of individual gangliosides differed from each other. CSF gangliosides change with age, reflecting the maturational changes of the central nervous system gangliosides in situ. CSF ganglioside analysis and this developmental profile might be useful for examining ganglioside aberrations and basic neurochemical mechanisms underlying neurologic disorders, especially age-dependent diseases.
Izumi
T
T
Department of Pediatrics, Oita Medical University, Japan.
Ogawa
T
T
Koizumi
H
H
Fukuyama
Y
Y
D000293:Adolescent; D001921:Brain / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005677:G(M1) Ganglioside / Q000134:cerebrospinal fluid; D005732:Gangliosides / Q000134:cerebrospinal fluid*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values
D005732:Gangliosides; C021298:ganglioside, GD1a; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside; C016481:trisialoganglioside GT1; C039129:GQ1b ganglioside