title: Basic problems in interaction assessment.
abstract: This paper reviews problems with the definition and estimation of interactions in epidemiologic studies. Methods for modeling interactions and dose-response also are reviewed, and references to more detailed literature are provided. Concepts are illustrated in the context of evaluating the joint effects of household radon exposure and environmental tobacco smoke.
authors.affiliation: Department of Epidemiology, UCLA School of Public Health 90024-1772.
authors.forename: S
authors.initials: S
authors.lastname: Greenland
mesh_terms: D015982:Bias; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D012307:Risk Factors