title: [Immunoglobulin levels in premature infants on a neonatology unit].
abstract: Serum IgG, IgA and IgM concentrations of premature infants, 21 boys and 17 girls, gestational age 29.8 +/- 2.5 weeks, birth weight 1243 +/- 378 gram, were measured during the first weeks post partum. At birth, IgG concentrations of newborn infants correlate with gestational age. Subsequently a gradual decline of IgG concentrations occurs. Infants of 25-29 weeks gestational age appeared to have significantly lower IgG concentrations if compared to infants of 29-32 weeks gestational age. IgA concentrations remained below the detection limit during the period covered by this study, whereas serum IgM concentrations showed a gradual increase. Significantly more infants from the group with IgG < 400 mg/dl, measured at the first day of life, had infections if compared to the group with IgG > 400 mg/dl. Exchange transfusions and administration of fresh frozen plasma (FFP) resulted in a rise of immunoglobulin concentrations, whereas administration of packed cells (PC's) and pasteurised plasma protein solution (GPO) did not.
authors.affiliation: Subafd. Neonatologie, Academisch Ziekenhuis Nijmegen St. Radboud.
authors.forename: E A
authors.initials: EA
authors.lastname: Voeten
authors.forename: B A
authors.initials: BA
authors.lastname: Semmekrot
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
mesh_terms: D001424:Bacterial Infections / Q000382:microbiology; D001724:Birth Weight; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D007136:Immunoglobulins / Q000302:isolation & purification*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology*; D008297:Male; D010949:Plasma / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins
vernacular_title: Immunoglobulinen-concentraties bij premature kinderen op een neonatologische afdeling.