[The pharmacological properties of a modified estrogen 11-nitrate-3-acetate-9 alpha, 11 beta-dioxyestrone].
The experiments on 715 adult non-inbred female rats and 111 Wistar male rats have established that the estrogen 11-nitrate of 3-acetoxy-9 alpha,11 beta-dioxyestra-1,3,5(10)-trien-17-one (11-nitrate of dioxyestron (NDE-As) has an oral contraceptive activity which is equal to ethynylestradiol (EE). A combined 14-day administration of NDE-As with various gestagens produces a higher contraceptive effect that does EE used in combination with the same gestagens. A 30-day use of NDE-As with combined acetomepregenol (AMP) results in a more significant and prolonged secretion of luteinizing hormone than does the EE-AMP combination. Unlike ethynylestradiol, NDE-As has no hypertriglyceridemic effect when given in oral doses of 0.25 and 1.25 mg/kg body weight.
Ivanenko
T I
TI
Pokrovskaia
E V
EV
Rzheznikov
E M
EM
Fedotov
V P
VP
D000818:Animals; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004970:Estrone / Q000031:analogs & derivatives / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood / Q000187:drug effects; D008297:Male; D009644:Norgestrel / Q000494:pharmacology; D011244:Pregnadienediols / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D008055:Lipids; D011244:Pregnadienediols; C027475:mepregenol diacetate; D004970:Estrone; D009644:Norgestrel; D004997:Ethinyl Estradiol; D007986:Luteinizing Hormone
Izuchenie nekotorykh farmakologicheskikh svoĭstv modifitsirovannogo éstrogena 11-nitrat-3-atsetat-9 al'fa, 11 beta-dioksiéstrona.