Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis.
A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As part of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent.
Ohnishi
M
M
School of Medicine, Teikyo University, Tokyo, Japan.
Kimura
S
S
Yamazaki
M
M
Oshima
H
H
Mizuno
D I
DI
Abe
S
S
Yamaguchi
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001886:Bordetella pertussis; D002460:Cell Line; D003520:Cyclophosphamide / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli; D005354:Fibrosarcoma / Q000188:drug therapy; D006090:Gram-Negative Bacteria; D007912:Lentinan / Q000627:therapeutic use; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008070:Lipopolysaccharides; D007912:Lentinan; D003520:Cyclophosphamide