title: The uptake of isoflurane during anaesthesia.
abstract: The uptake of isoflurane at a constant end-expired concentration of 1.5% in oxygen was studied in 15 women, ASA 1 or 2, undergoing elective total abdominal hysterectomy. The anaesthetic was administered by a simple computer-controlled to-and-fro closed system. After an initial period of wash-in to the system, the rate of uptake of isoflurane decreased bi-exponentially with a rapid reduction during the first 15 min. Perturbations from this bi-exponential decline reflect changes in cardiac output. The mean (SD) cumulative use of isoflurane was 4.5 (0.43) ml after 30 min and 7.3 (0.79) ml after 60 min.
authors.affiliation: Department of Anaesthesia, Hammersmith Hospital, London.
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
mesh_terms: D000328:Adult; D000368:Aged; D000764:Anesthesia, Closed-Circuit; D000769:Anesthesia, Inhalation; D002245:Carbon Dioxide / Q000502:physiology; D003201:Computers; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007530:Isoflurane / Q000493:pharmacokinetics*; D008875:Middle Aged
chemical_list: D002245:Carbon Dioxide; D007530:Isoflurane