title: An evaluation of vesical urodynamics before renal transplantation and its effect on renal allograft function and survival.
abstract: This prospective study investigated the urodynamics of the urinary bladder prior to renal transplantation in 57 patients and related this to graft function and transplantation outcome. The study demonstrated a clear deterioration in the pretransplant urodynamic characteristics in all subgroups, with male patients in the hemodialysis group (HD) showing a more substantial decline: 1st sensation volume (ml) in male HD patients = 112 (120) vs. 171 (173) in male CAPD patients, P < 0.05; and corresponding average flow rate for same groups 3 (3) ml/sec vs. 5 (5) ml/sec, P < 0.05. Figures are median (interquartile range). We have identified a subgroup of patients with a small bladder capacity (less than 100 ml) who have a reduced graft survival (55% vs. 92% for bladders larger than 100 ml at 2 years) apparently unrelated to immunological processes.
authors.affiliation: Academic Unit of Surgery, St. James's University Hospital, Leeds, United Kingdom.
authors.forename: S H
authors.initials: SH
authors.lastname: Kashi
authors.forename: K S
authors.initials: KS
authors.lastname: Wynne
authors.forename: S A
authors.initials: SA
authors.lastname: Sadek
authors.forename: J P
authors.initials: JP
authors.lastname: Lodge
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D001743:Urinary Bladder / Q000502:physiology*; D014552:Urinary Tract Infections / Q000150:complications