Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution.
The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release of hepatocellular enzymes (ASAT, ALAT, and LDH) into the perfusate was determined with increasing time. Both drugs reduced the amount of enzymes lost from the liver. The combination of the two drugs was better than either drug alone. These data suggest that both agents may be of value in organ preservation for clinical liver transplantation.
Jacobsson
J
J
Department of Surgery, University of Pittsburgh, PA 15213.
Sundberg
R
R
Rilo
H L
HL
Gasbarrini
A
A
Starzl
T E
TE
Van Thiel
D
D
D000241:Adenosine / Q000494:pharmacology; D000410:Alanine Transaminase / Q000378:metabolism; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008013:Lidoflazine / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011281:Pregnatrienes / Q000494:pharmacology*; D011887:Raffinose / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D015427:Reperfusion Injury / Q000517:prevention & control
D007328:Insulin; D008054:Lipid Peroxides; D019188:Organ Preservation Solutions; D011281:Pregnatrienes; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; C053356:U 74500A; D008013:Lidoflazine; D000241:Adenosine; D011887:Raffinose