title: Effect of supine exercise on platelet aggregation and fibrinolytic activity.
abstract: In 12 healthy young men, strenuous cycling exercise in the supine position, caused platelet aggregability to decrease and the ADP threshold to rise from 7.0 microM resting, to 9.5 exercising (P < 0.01). At the same time, fibrinolytic activity increased markedly: euglobulin clot lysis time shortened from 178 to 68 min, PAI-1 fell from 8.91 to 5.16 IU ml-1, and t-PA rose from 0.56 to 3.95 IU ml-1, all three values were significant to P < 0.01. When the erect posture was assumed after lying at ease for 1 h after exercise, it did not increase platelet activity as expected, but caused a modest increase of fibrinolytic activity. These results suggest that supine exercise will not affect the haemostatic system adversely.
authors.affiliation: Department of Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Dag
authors.forename: G
authors.initials: G
authors.lastname: Gleerup
authors.forename: A M
authors.initials: AM
authors.lastname: Bak
authors.forename: I
authors.initials: I
authors.lastname: Hindberg
authors.forename: J
authors.initials: J
authors.lastname: Mehlsen
authors.forename: K
authors.initials: K
authors.lastname: Winther
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology*; D012701:Serotonin / Q000097:blood; D012712:Serum Globulins / Q000502:physiology; D016683:Supine Position / Q000502:physiology*
chemical_list: D002395:Catecholamines; D012712:Serum Globulins; D012701:Serotonin