title: Chordomas and chondrosarcomas involving the cavernous sinus: review of surgical treatment and outcome in 31 patients.
abstract: During the last 9 years, 31 patients with chordomas (20 cases) and chondrosarcomas (11 cases) involving the cavernous sinus have been treated using an aggressive surgical approach. On the basis of postoperative magnetic resonance imaging (MRI), 17 patients were considered to have undergone total removal, whereas in the remaining 14 cases the tumor was either subtotally or partially removed. Surgical complications were most commonly encountered among patients who had undergone previous operations. One patient died 3 months after the operation as a result of pulmonary embolism. Significant disability occurred in one patient because of thalamic perforator occlusion and hemorrhage. Recovery of extraocular muscle function was gratifying, and correlated to the preoperative functional level. After a median follow-up of 24 months, three recurrences (21%) occurred among the 14 patients who had undergone incomplete removal. No recurrence was observed among the 17 patients with total resection. This experience shows that gross radical removal of chordomas and chondrosarcomas involving the cavernous sinus can be accomplished with an acceptable surgical morbidity. However, much longer follow-up will be required to determine whether such aggressive surgical treatment results in cure or long-term control of these neoplasms.
authors.affiliation: Department of Neurosurgery, University of Virginia Medical Center.
authors.forename: G
authors.initials: G
authors.lastname: Lanzino
authors.forename: L N
authors.initials: LN
authors.lastname: Sekhar
authors.forename: W L
authors.initials: WL
authors.lastname: Hirsch
authors.forename: C N
authors.initials: CN
authors.lastname: Sen
authors.forename: S
authors.initials: S
authors.lastname: Pomonis
authors.forename: C H
authors.initials: CH
authors.lastname: Snyderman
mesh_terms: D000293:Adolescent; D000328:Adult; D002426:Cavernous Sinus / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D002813:Chondrosarcoma / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D002817:Chordoma / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011183:Postoperative Complications; D012888:Skull Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome