title: A defect-in-continuity in the canine femur: and in-vivo experimental model for the study of bone graft incorporation.
abstract: The in-vivo study of bone graft incorporation has traditionally used a segmental diaphyseal bone defect. This model reliably produces a nonunion, but is complicated by graft instability and altered limb loading stresses. The authors discuss the advantages of a defect-in-continuity canine femur model which produces a more consistent union with fewer mechanical complications despite the absence of fixation. This proposed model permits analysis of radiographic, histologic and biomechanical data which are more applicable to the usual clinical setting in which bone graft is required.
authors.affiliation: Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, Texas.
authors.forename: R W
authors.initials: RW
authors.lastname: Lindsey
authors.forename: T
authors.initials: T
authors.lastname: Miclau
authors.forename: R
authors.initials: R
authors.lastname: Probe
authors.forename: S
authors.initials: S
authors.lastname: Perren
mesh_terms: D000818:Animals; D001843:Bone Cements; D016025:Bone Transplantation; D002146:Bony Callus / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D006085:Graft Survival; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D011859:Radiography; D013314:Stress, Mechanical; D014031:Tobramycin / Q000627:therapeutic use; D016474:Weight-Bearing; D014945:Wound Healing
chemical_list: D001843:Bone Cements; D008768:Methylmethacrylates; D020366:Methylmethacrylate; D014031:Tobramycin