New teleocidin-related metabolites, (-)-7-geranylindolactam V and blastmycetin F, from Streptoverticillium blastmyceticum.
Two new teleocidin-related metabolites, (-)-7-geranylindolactam-V [2] and blastmycetin F [3], were isolated from fermentation broths of the actinomycete Streptoverticillium blastmyceticum NA34-17, and their structures were determined by spectroscopic methods. Compound 2 bound strongly to phorbol ester receptors in a mouse epidermal particulate fraction, suggesting that it is a potent in vivo tumor promoter comparable to teleocidins A-1 [4] and B-4 [5].
Irie
K
K
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.
Kajiyama
S
S
Okuno
S
S
Kondo
M
M
Koshimizu
K
K
Hayashi
H
H
Arai
M
M
Nishino
H
H
Iwashima
A
A
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002273:Carcinogens / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D007769:Lactams / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013306:Streptomycetaceae / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000493:pharmacokinetics
D002273:Carcinogens; D007211:Indoles; D007769:Lactams; D010743:Phospholipids; C087534:7-geranylindolactam V; C087535:blastmycetin F; D013755:Tetradecanoylphorbol Acetate