Oxygen free radicals and protective effect of captopril on myocardial infarct size.
Captopril (0.25 mg/kg and 0.5 mg/kg, p.o.) decreased the myocardial infarct size and prevented the progressive decrease in voltage of the R wave in rats. It had no marked effect on systolic blood pressure at these dose levels but higher doses (1 mg/kg, p.o.) reduced systolic blood pressure. It also produced a concentration-dependent (50-700 ng/10(6) cells) decrease of chemiluminescence response from rat neutrophils and markedly reduced serum malonyldialdehyde levels, elevated as a consequence of left coronary artery ligation. It is suggested that the protective effect of captopril may be mediated through a decreased formation or scavenging of reactive oxygen species.
Chopra
K
K
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Singh
M
M
Kaul
N
N
Ganguly
N K
NK
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005609:Free Radicals; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008163:Luminescent Measurements; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D017382:Reactive Oxygen Species
D005609:Free Radicals; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D002216:Captopril