title: Time dependency of the antihypertensive efficacy of the new renin inhibitor Ro 42-5892.
abstract: The objective of this study was to assess the antihypertensive efficacy of the new renin inhibitor Ro 42-5892 in patients with essential hypertension treated with 100 mg once daily orally. This was a double-blind, placebo-controlled, parallel group trial. After three weeks of wash-out and one week of single-blind placebo run-in periods, 25 patients with mild to moderate essential hypertension (sitting DBP between 95 and 114 mmHg) were randomised to receive either placebo (n = 12) or 100 mg of Ro 42-5892 (n = 13) once daily for eight days. On the eighth day, four hours after the oral administration, patients were randomised to receive intravenously either placebo or 10 mg of Ro 42-5892. BP and heart rate were measured repeatedly (hourly for eight hours and at the 24th hour post-dose) on the first and last days of active treatment. Compared with the placebo group, a slight decrease in sitting DBP was observed after the first dose in the Ro 42-5892 group. The decrease in sitting DBP reached significant levels only at six to eight hours post-dosing. In contrast, on the last day of active treatment, a larger, faster and longer decrease in sitting DBP was observed in the Ro 42-5892 group. Thus, the peak effect (-8.9 +/- 1.9 vs. -2.9 +/- 1.3 mmHg, P < 0.01) was reached 1.5 hours post-dosing and the trough effect (24 hours post-dosing) was slightly but significantly lower when compared with the placebo group (-3.0 +/- 1.0 vs -0.3 +/- 0.8 mmHg, P < 0.05, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Barzilaï Medical Centre, Department of Medicine B, Beersheva, Israel.
authors.forename: R J
authors.initials: RJ
authors.lastname: Viskoper
authors.forename: V
authors.initials: V
authors.lastname: Charlon
authors.forename: A
authors.initials: A
authors.lastname: Laszt
authors.forename: C
authors.initials: C
authors.lastname: Yosefy
authors.forename: J
authors.initials: J
authors.lastname: Bock
authors.forename: M
authors.initials: M
authors.lastname: Landau
authors.forename: I
authors.initials: I
authors.lastname: Kobrin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D000092502:Renin Inhibitors
chemical_list: D000959:Antihypertensive Agents; D007093:Imidazoles; D000092502:Renin Inhibitors; C065581:remikiren