title: Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women.
abstract: Effects of two experimental diets with a relatively high fat content--one enriched with saturated fatty acids (SAFA-diet) and the other with a low content of erucic acid rapeseed oil and rich in monounsaturated fatty acids (MUFA-diet)--on glucose and lipid metabolism were examined in healthy young women. The study was carried out with a randomized, crossover study design with each diet lasting 3 wk and a 2-wk washout period between the experimental diets. Glucose area under the curve during the intravenous glucose tolerance test (glucose dose 300 mg/kg, plasma samples before glucose dose and at 10-min intervals for 90 min) was significantly lower and the glucose disappearance rate after a glucose injection tended to be steeper after the MUFA-diet than after the SAFA-diet. After the MUFA-diet serum total cholesterol was 21.6% lower and serum low-density-lipoprotein cholesterol 29.5% lower than after the SAFA-diet, but high-density-lipoprotein cholesterol did not differ between the diets. The results give suggestive evidence that the dietary fatty acid composition affects glucose tolerance of healthy subjects.
authors.affiliation: Department of Clinical Nutrition, University of Kuopio, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Uusitupa
authors.forename: U
authors.initials: U
authors.lastname: Schwab
authors.forename: S
authors.initials: S
authors.lastname: Mäkimattila
authors.forename: P
authors.initials: P
authors.lastname: Karhapää
authors.forename: E
authors.initials: E
authors.lastname: Sarkkinen
authors.forename: H
authors.initials: H
authors.lastname: Maliranta
authors.forename: J
authors.initials: J
authors.lastname: Agren
authors.forename: I
authors.initials: I
authors.lastname: Penttilä
mesh_terms: D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D005227:Fatty Acids / Q000008:administration & dosage / Q000378:metabolism*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D050356:Lipid Metabolism
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005947:Glucose