title: Hemodynamic changes in acute adrenal insufficiency.
abstract: OBJECTIVE
  Acute adrenocortical insufficiency is an unusual cause of isolated shock. The purpose of this study is to describe the cardiovascular changes in 6 patients with acute adrenal insufficiency presenting with hemodynamic instability.
  
  
  METHODS
  Retrospective and prospective study.
  
  
  METHODS
  Medical intensive care unit in a university hospital.
  
  
  METHODS
  6 patients studied by right cardiac catheterization.
  
  
  RESULTS
  Results before glucocorticoid treatment show two possible hemodynamic states: 1) myocardial depression with hypovolemia in 3 patients, and 2) hyperdynamic shock with high cardiac output and diminished systemic arterial resistance in 3 other patients. The 3 patients presenting hyperdynamic shock were all given intravenous fluid therapy of over 20 ml/kg before the first hemodynamic measurement. For 2 other patients with low cardiac index and high systemic arterial resistance studied prospectively, 20 ml/kg intravenous fluid therapy transformed the hemodynamic state to hyperdynamic shock. The cardiovascular effect of glucocorticoid treatment studied in 4 patients was resulted in an improvement in the left ventricular systolic work index.
  
  
  CONCLUSIONS
  Diagnosis of acute adrenocortical insufficiency must be considered if clinical manifestations are present suggesting septic shock without any obvious infectious cause in patients having undergone considerable intravenous fluid therapy as an initial course of treatment.
authors.affiliation: Service de Réanimation Médicale, Centre Hospitalier Universitaire, Angers, France.
authors.forename: G
authors.initials: G
authors.lastname: Bouachour
authors.forename: P
authors.initials: P
authors.lastname: Tirot
authors.forename: N
authors.initials: N
authors.lastname: Varache
authors.forename: J P
authors.initials: JP
authors.lastname: Gouello
authors.forename: P
authors.initials: P
authors.lastname: Harry
authors.forename: P
authors.initials: P
authors.lastname: Alquier
mesh_terms: D000208:Acute Disease; D000309:Adrenal Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D006328:Cardiac Catheterization; D005260:Female; D005440:Fluid Therapy; D005780:Gelatin / Q000494:pharmacology / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000494:pharmacology / Q000627:therapeutic use; D011446:Prospective Studies; D012189:Retrospective Studies; D012769:Shock / Q000209:etiology* / Q000503:physiopathology
chemical_list: D010952:Plasma Substitutes; D000450:Aldosterone; C013648:plasmion; D005780:Gelatin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone