The interleukin-8-receptor family: from chemokines to malaria.
The interleukin 8 (IL-8)-receptor family includes two specific receptors (type A and B) that both bind IL-8 with high affinity. These receptors have been cloned, and belong to a superfamily of G-protein-linked receptors that signal in response to IL-8 on a variety of cell types. In contrast to these receptors, which have a narrow ligand-binding profile, a promiscuous IL-8 receptor has been found on human erythrocytes that binds a variety of chemokines with high affinity. This protein, known as the chemokine receptor, was recently shown to bind the malarial parasite Plasmodium vivax, and may play a major role in inflammation by limiting the concentration of soluble chemokines in the circulation.
Horuk
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Dept of Protein Chemistry, Genentech Inc., South San Francisco, CA 94080.
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan; D002630:Chemotactic Factors / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology; D008288:Malaria / Q000276:immunology; D008969:Molecular Sequence Data; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface / Q000502:physiology; D018123:Receptors, Interleukin / Q000737:chemistry* / Q000502:physiology*; D023062:Receptors, Interleukin-8A; D015398:Signal Transduction / Q000276:immunology
D000953:Antigens, Protozoan; D002630:Chemotactic Factors; D016207:Cytokines; C066001:Duffy antigen binding protein, Plasmodium; D016209:Interleukin-8; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A