Anomalous transforming behavior of a bovine papillomavirus type 1 mutant with an upstream promoter mutation.
We show that the previously described high-transformation phenotype of the bovine papillomavirus type 1 mutant BPV730 is manifested only in an E6-dependent cell transformation assay. The BPV730 mutation was associated with superinduction of the putative E6 promoter, P89, after cycloheximide treatment, and with reduced activity of the P3080 promoter.
Stewart
A C
AC
Department of Medical Genetics, Uppsala University, Sweden.
Burnett
S
S
D052688:Bovine papillomavirus 1 / Q000235:genetics* / Q000502:physiology; D002472:Cell Transformation, Viral / Q000235:genetics; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D009154:Mutation; D011401:Promoter Regions, Genetic; D017384:Sequence Deletion
D003513:Cycloheximide