[Cross-reacting HLA antigens as a factor increasing the risk of childlessness in a family].
A comparative analysis of HLA phenotypes of fertile and infertile spouses revealed that among the infertile the sum of spouses showed compatibility in two or three HLA antigens. A detailed analysis also showed that 10 infertile couples exhibited identical and 2 antigens with a similar structure and function with so-called cross-reactions increasing the histocompatibility index to 75%. The significance of these facts for infertility risk factors is discussed.
Montag
T S
TS
Drannik
G N
GN
Gorpinchenko
I I
II
Bystrov
L A
LA
Sokolova
M N
MN
Vashchenko
S N
SN
D003429:Cross Reactions / Q000276:immunology; D005260:Female; D005298:Fertility / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000276:immunology*; D007248:Infertility, Male / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors
D006680:HLA Antigens
Perekrestnoreagiruiushchie antigeny sistemy HLA kak fator, povyshaiushchiĭ risk bezdetnosti v sem'e.