title: Fulminant amebic colitis. A morphologic study of four cases.
abstract: OBJECTIVE
  The morphologic features of fulminant amebic colitis are poorly documented. In this report, we describe the clinical and pathologic findings in four of these cases.
  
  
  METHODS
  The surgical pathology reports and accompanying histologic slides were examined from four patients who underwent surgical resections for fulminant amebic colitis. Clinical information was obtained from the patients' medical records.
  
  
  RESULTS
  Large, geographic mucosal ulcers were typically present and were accompanied by yellow-green pseudomembranes. The muscularis externa was usually attenuated and necrotic, imparting a "wet blotting paper" consistency. Large numbers of amebic trophozoites were present within the inflammatory exudates. The mucosa adjacent to and undermined by the ulcers was often hemorrhagic or inflamed, resembling ischemic colitis or idiopathic inflammatory bowel disease, respectively. Two patients died within four weeks of their surgery. A third patient died one year later as a result of AIDS-related complications. The remaining patient has been lost to follow-up.
  
  
  CONCLUSIONS
  An uncommon but life-threatening manifestation of intestinal amebiasis is a fulminant colitis. Early surgical intervention and intensive antiamebic chemotherapy are essential for efficacious management.
authors.affiliation: Department of Pathology, Los Angeles County-University of Southern California Medical Center, University of Southern California School of Medicine, 90033.
authors.forename: D
authors.initials: D
authors.lastname: Chun
authors.forename: P
authors.initials: P
authors.lastname: Chandrasoma
authors.forename: M
authors.initials: M
authors.lastname: Kiyabu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology; D000368:Aged; D003106:Colon / Q000469:parasitology / Q000473:pathology*; D004404:Dysentery, Amebic / Q000469:parasitology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis