Selection of Candida glabrata in pediatric bone marrow transplant recipients receiving fluconazole.
We observed an alarmingly high rate (5/16 patients; 31.3%) of orointestinal colonization with Candida glabrata--often in high numbers--in pediatric bone marrow transplant recipients receiving fluconazole as antifungal prophylaxis. This selection is probably due to the intrinsically low susceptibility of C. glabrata to fluconazole.
Hoppe
J E
JE
Department of Pediatric Hematology and Oncology, University Children's Hospital, Tübingen, Germany.
Klingebiel
T
T
Niethammer
D
D
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002175:Candida / Q000187:drug effects*; D002648:Child; D005243:Feces / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D009055:Mouth / Q000382:microbiology
D015725:Fluconazole