title: [The role of adrenal gland x-ray computed tomography and scintigraphy using radiolabelled norcholesterol in the etiological diagnosis of primary hyperaldosteronism].
abstract: The major etiologies of primary aldosteronism are aldosterone-producing adrenal adenoma, requiring a surgical treatment, and bilateral hyperplasia, usually managed with medical therapy. We only report a retrospective study on 22 patients with primary aldosteronism diagnosed by clinical and usual biochemical tests. All the patients were explored by computed tomography scan (CT) and iodomethyl-norcholesterol scintigraphy. The purpose of this study was to compare the capacity of the two methods to differentiate adrenal adenoma and hyperplasia. The CT scan was more sensitive (sensitivity: 88%) compare to scintigraphy (sensitivity: 64%) for the diagnosis of adrenal adenoma. However, the scintigraphy was a useful tool to detect asymmetric macronodular adrenal hyperplasia. Therefore, the catheterisation of adrenal venous would be only necessary for a few cases. We conclude from this study and the literature review that CT scan and iodomethyl-norcholesterol scintigraphy are complementary and both useful to increase diagnostic reliability of primary aldosteronism.
authors.affiliation: Clinique d'endocrinologie, maladies métaboliques, nutrition, CHRU, Hôtel-Dieu, Nantes, France.
authors.forename: M
authors.initials: M
authors.lastname: Abram
authors.forename: P
authors.initials: P
authors.lastname: Peltier
authors.forename: A
authors.initials: A
authors.lastname: Murat
authors.forename: M
authors.initials: M
authors.lastname: Chupin
authors.forename: B
authors.initials: B
authors.lastname: Dupas
authors.forename: F
authors.initials: F
authors.lastname: Gaillard
authors.forename: J F
authors.initials: JF
authors.lastname: Chatal
authors.forename: B
authors.initials: B
authors.lastname: Charbonnel
mesh_terms: D015071:19-Iodocholesterol / Q000031:analogs & derivatives*; D000236:Adenoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000000981:diagnostic imaging / Q000209:etiology*; D006965:Hyperplasia; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes; D015071:19-Iodocholesterol; C035501:6-iodomethylcholesterol
vernacular_title: Place respective de la tomodensitométrie surrénalienne et de la scintigraphie au norcholestérol radiomarqué dans le diagnostic étiologique des hyperaldostéronismes primaires.