Syphilitic placentitis: an immunopathy.
The placentas of eight infants with congenital syphilis were examined by both immunohistochemical and immunofluorescent techniques. Significant IgM, C3 and rheumatoid factor reactivity were observed in all the syphilitic placentas. We postulate that their presence plays an important role in the evolution of the pathological changes.
Samson
G R
GR
Department of Paediatrics, Groote Schuur Hospital, University of Cape Town, RSA.
Meyer
M P
MP
Blake
D R
DR
Cohen
M C
MC
Mouton
S C
SC
D000936:Antigen-Antibody Complex / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D010920:Placenta / Q000737:chemistry / Q000473:pathology; D010922:Placenta Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology; D011247:Pregnancy; D012217:Rheumatoid Factor / Q000032:analysis; D013590:Syphilis, Congenital / Q000150:complications* / Q000276:immunology / Q000473:pathology
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007075:Immunoglobulin M; D012217:Rheumatoid Factor