Physiologic support of the septic patient.
The patient's response to inflammation, referred to as sepsis, is a complex process involving the degree of the inflammatory insult and the host response. Ischemia, from blood flow abnormalities and direct cell injury from mediators, produces the physiologic response. The treatment is focused first on restoring and maintaining perfusion through maintenance of increased oxygen delivery. The second approach is first surgical then pharmacologic attenuation of the inflammation-induced injury.
Demling
R H
RH
Longwood Area Trauma Center, Brigham and Women's Hospital, Boston, Massachusetts.
Lalonde
C
C
Ikegami
K
K
D006439:Hemodynamics / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000503:physiopathology / Q000517:prevention & control*; D010146:Pain / Q000503:physiopathology; D012772:Shock, Septic / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*
D006728:Hormones