[Antiendomysial antibodies: current role in the diagnosis of celiac disease compared to antigliadin antibodies].
We evaluated in parallel the action of antigliadin (AGA-IgA) and anti-endomysium (EmA) antibodies in a group of 144 coeliac patients during the various diagnostic procedures, and in 277 controls (206 affected by other gastroenterological diseases and 71 healthy or affected by non-gastroenterological diseases, not causing any immune changes). Little difference was observed between the two tests both during the initial phase of the disease and during gluten-free diet. No EmA positivity was observed in controls; AGA-IgA resulted positive in 6.3% of gastroenterological controls and in 5.6% of non-gastroenterological controls. Finally, the sensitivity, specificity and predictability of the two tests were evaluated in a sample of 92 subjects undergoing intestinal biopsy. The results show that the tests have the same sensitivity, but only for EmA 100% specificity was found.
Gemme
G
G
Istituto di Clinica Pediatrica G. Gaslini, Università di Genova, Italia.
Delogu
A
A
Nobili
F
F
Galeazzi
G
G
Mariani
P
P
Triglione
P
P
Bonamico
M
M
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007223:Infant; D009132:Muscles / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D005903:Gliadin
Anticorpi antiendomisio: ruolo attuale nella diagnosi di malattia celiaca a confronto con gli anticorpi anti-gliadina.