A single intravenous high dose of cholic acid to a pregnant ewe does not affect fetal well-being.
Cardiovascular variables of both mother and fetus and total bile acid levels were monitored in amniotic fluid and in maternal and fetal plasma after the administration of a single intravenous high dose (29 mg) of cholic acid to a pregnant ewe. We observed the diffusion of significant quantities of cholic acids from the mother to the fetus and amniotic fluid. Nevertheless, cardiovascular parameters (heart rate, blood pressure, PO2, PCO2 and pH) were not affected, neither did intra-amniotic pressure show significant changes compared with the initial experimental conditions. It is concluded that an acute increase in maternal plasma levels of bile acids does not produce important adverse effects in either the mother animal or the fetus and consequently, if bile acids should be deemed responsible for any deleterious effect observed in a preterm fetus in intrahepatic cholestasis, this should be considered as the consequence of a chronic process.
Perez
R
R
Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Garcia
M
M
Ulloa
N
N
Jara
C
C
Bardisa
L
L
Rudolph
M I
MI
D000818:Animals; D002780:Cholestasis, Intrahepatic / Q000378:metabolism* / Q000503:physiopathology; D019826:Cholic Acid; D002793:Cholic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005333:Fetus / Q000378:metabolism* / Q000502:physiology; D006439:Hemodynamics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D012756:Sheep; D014590:Uterine Contraction
D002793:Cholic Acids; D019826:Cholic Acid