[The significance of lipid peroxidation in the chronicity of glomerulonephritis with a hematuric component].
Measures of lipid peroxidation (malonaldehyde contents in blood, erythrocyte membranes and urine), parameters of the antioxidant system, structural and functional indices of cell membranes (cholesterol level, general content of phospholipids and phospholipid spectrum) were studied in patients with acute and chronic (stable and advancing) hematuric glomerulonephritis. Glomerulonephritis chronization was established to be associated with the activation of lipid peroxidation, predominantly on the level of damaged organ, while the condition of the antioxidant system showed a trend to normalization. Advancing glomerulonephritis when compared to stable one revealed more pronounced processes of membrane destabilization as well as accumulation of lipid peroxidation products in membranes, erythrocytes, blood plasma and urine.
Dudar
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Kolesnyk
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Nikulina
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Pyrih
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LA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000032:analysis; D002908:Chronic Disease; D004910:Erythrocyte Membrane / Q000737:chemistry; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism*; D006417:Hematuria / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008563:Membrane Lipids / Q000097:blood
D000975:Antioxidants; D008563:Membrane Lipids; D008315:Malondialdehyde
Znachennia perekysnoho kyslennia lipidiv u khronizatsiï hlomerulonefrytu z hematurychnym komponentom.