Long-term effects of Aroclor 1254 (PCBs) on plasma lipid and carnitine concentrations in rhesus monkey.
Sixty-seven female rhesus monkeys (Macaca mulatta) were orally dosed daily for 152 weeks with 0, 5, 20, 40, and 80 micrograms Aroclor 1254 (PCB)/kg body wt. Blood polychlorinated biphenyl (PCB) concentrations were highly positively correlated (r = 0.92, P < 0.001) with doses of PCB administered. A comprehensive analysis of plasma lipids/lipoproteins revealed a PCB-associated increase in plasma triglycerides and decreases in plasma total cholesterol, high-density lipoprotein cholesterol (HDL-chol), very-low plus low-density lipoprotein cholesterol (VLDL+LDL-chol), and total carnitine (which is involved in fatty acid metabolism). All of the lipid/lipoprotein changes were significantly (P < or = 0.05) correlated with blood PCB concentration. These data, obtained after 152 weeks of continuous daily exposure of a primate model to PCB support a causal relationship between plasma lipid changes and PCB intake. Previously, causality has been refuted on the premise that the commonly observed elevation of triglycerides with increasing concentration of blood PCB is a reflection, not of PCB dose, but of the partitioning of PCB between tissues (adipose) and blood in proportion to the blood lipid present. The mechanism of the plasma lipid changes was not investigated in this study but the altered lipid/lipoprotein pattern is discussed with respect to known cardiovascular risk profiles.
Bell
F P
FP
Metabolic Diseases Research, Unit 7250, Upjohn Laboratories, Kalamazoo, MI 49001.
Iverson
F
F
Arnold
D
D
Vidmar
T J
TJ
D000284:Administration, Oral; D000818:Animals; D001140:Aroclors / Q000097:blood / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D002331:Carnitine / Q000097:blood*; D020111:Chlorodiphenyl (54% Chlorine); D002784:Cholesterol / Q000097:blood; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D005260:Female; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008253:Macaca mulatta; D014280:Triglycerides / Q000097:blood
D001140:Aroclors; D002273:Carcinogens; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D020111:Chlorodiphenyl (54% Chlorine); D002784:Cholesterol; D002331:Carnitine