Synthesis and antitumor activity of some new 2-chloroethylnitrosoureas.
The synthesis of a series of N-(2-chloroethyl)-N'-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N'-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N'-(2-methoxy-9H-xanthen-9-yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.
Filippatos
E
E
Department of Pharmaceutical Chemistry, University of Athens, Greece.
Papadaki-Valiraki
A
A
Roussakis
C
C
Verbist
J F
JF
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005038:Ethylnitrosourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005038:Ethylnitrosourea