Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis.
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
Lauhio
A
A
Department of Internal Medicine, Aurora Hospital, Helsinki, Finland.
Konttinen
Y T
YT
Tschesche
H
H
Nordström
D
D
Salo
T
T
Lähdevirta
J
J
Golub
L M
LM
Sorsa
T
T
D000328:Adult; D016918:Arthritis, Reactive / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology*; D002690:Chlamydia Infections / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D002692:Chlamydia trachomatis; D017364:Collagenases / Q000097:blood / Q000378:metabolism*; D004318:Doxycycline / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8; D012480:Salmonella Infections / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D015009:Yersinia Infections / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D015008:Yersinia enterocolitica
D017364:Collagenases; D020784:Matrix Metalloproteinase 8; D004318:Doxycycline