[Free oxygen radicals in patients with diabetes mellitus].
Free oxygen radicals (FOR) are one of the factors which participate via lipoperoxides in the development of atherosclerosis. Atherosclerosis complications affect a large part of diabetic patients. The objective of the present work was to test whether in diabetic patients there is, as compared with healthy subjects, a difference in the FOR activity and in the lipoperoxide blood level. A total of 30 patients with insulin non-dependent diabetes and a control group of 31 healthy subjects were examined. The FOR formation in blood, the concentration of malondialdehyde (MDA) as a marker of lipid paroxidation and serum lipid concentrations were assessed. In patients with diabetes a statistically significant increase in the FOR formation in blood (p < 0.01) and an increased MDA serum concentration (p < 0.01) were found. The mean serum lipid concentrations in the two groups did not differ significantly. The results suggest a significant participation role of highly reactive oxygen species in the development of vascular atherosclerosis complications.
Soska
V
V
Oddĕlení klinické biochemie, Fakultní nemocnice U svaté Anny, Brno.
Krusová
D
D
Podrouzková
B
B
Lojek
A
A
Zechmeister
A
A
D000368:Aged; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged
D005609:Free Radicals
Kyslíkové volné radikály u nemocných s diabetes mellitus.