Sequential approach for describing channel opening and desensitization.
A formula describing the time-course of activation and desensitization of nicotinic-like acetylcholine channels is developed. The method used to arrive at this simplified formula is based on a sequential approach. Based upon this approximated and simple formula, analytical expressions for various specific experimental aspects are derived. These expressions together with the corresponding experiments provide a method to evaluate in a sequential manner the various rate constants involved.
Buchman
E
E
Department of Neurobiology, Hebrew University of Jerusalem, Israel.
Parnas
H
H
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D003198:Computer Simulation; D015640:Ion Channel Gating / Q000502:physiology*; D008433:Mathematics; D008956:Models, Chemical; D013997:Time Factors
D000109:Acetylcholine