title: Correlation of clinical response (PANSS) and plasma levels of haloperidol and reduced haloperidol in schizophrenia.
abstract: 1. The authors attempted to correlate plasma concentrations in H/rH and clinical efficacy from 8 schizophrenic patients (DSM IIIR) on H. 2. No significant correlations were found between H, rH plasma levels and positive and negative subscale for each patient. 3. The authors observed an opposite evolution concerning the mean results between plasma concentrations and PANSS total score.
authors.affiliation: Faculté de Pharmacie, Lille, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Leroux
authors.forename: E
authors.initials: E
authors.lastname: Elia
authors.forename: M
authors.initials: M
authors.lastname: Jacquet
authors.forename: J
authors.initials: J
authors.lastname: Pommery
authors.forename: J C
authors.initials: JC
authors.lastname: Levron
authors.forename: P
authors.initials: P
authors.lastname: Bouhours
authors.forename: F
authors.initials: F
authors.lastname: Erb
authors.forename: D
authors.initials: D
authors.lastname: Sechter
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006220:Haloperidol / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013056:Spectrophotometry, Ultraviolet
chemical_list: C040692:4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol; D006220:Haloperidol