title: [Pentoxifylline is not useful in the prevention of toxicity associated with bone marrow transplantation].
abstract: BACKGROUND
  To evaluate the possible beneficial effect of pentoxifylline (PTX) on both the decrease of toxicity related to bone marrow transplantation (BMT) and the acceleration of the hematopoietic graft.
  
  
  METHODS
  Twenty consecutive patients treated with BMT received pentoxifylline (400 mg/6 hours, orally) up to day +50 to prevent toxicity derived from BMT. A previous group of 29 consecutive patients transplanted in the same center were used as controls. The different clinical toxicities (mucositis, kidney failure, hepatic venocclusive disease, graft versus host disease, number of days with fever, day of hospital discharge and survival at day +50), the time elapsed until the hematopoietic graft and the levels of tumoral necrosis factor alpha were evaluated.
  
  
  RESULTS
  No significant differences were observed in any of the parameters studied in the two groups of patients.
  
  
  CONCLUSIONS
  Treatment with pentoxifylline does not prevent the toxicity derived from BMT or accelerate the hematopoietic grafting.
authors.affiliation: Servicio de Hematología, Hospital Ramón y Cajal, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: López
authors.forename: J A
authors.initials: JA
authors.lastname: Cancelas
authors.forename: J M
authors.initials: JM
authors.lastname: Valiño
authors.forename: J
authors.initials: J
authors.lastname: García-Laraña
authors.forename: J L
authors.initials: JL
authors.lastname: Sastre
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Oteyza
authors.forename: C
authors.initials: C
authors.lastname: Cerveró
authors.forename: A
authors.initials: A
authors.lastname: García-Avello
authors.forename: E
authors.initials: E
authors.lastname: Cabezudo
authors.forename: M I
authors.initials: MI
authors.lastname: Arranz
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline
vernacular_title: La pentoxifilina no es útil en la prevención de la toxicidad asociada al trasplante de médula ósea.