Serum pepsinogens in patients with gastric diseases or after gastric surgery.
As no comparative study is available on the categorized serum pepsinogen A and C concentrations, we have measured serum pepsinogens in patients with gastric diseases and after gastric surgery. Hyperpepsinogenemia A (> 120 micrograms/l) occurred frequently in patients with the Zollinger-Ellison syndrome (71%) and hypertrophic gastropathy (100%), whereas hypopepsinogenemia A (< 17 micrograms/l) was found mostly in patients with achlorhydria (87%) and after total gastrectomy (100%). Patients with the Zollinger-Ellison syndrome frequently (58%) had hyperpepsinogenemia C (> 40 micrograms/l), which was also the case in all patients with hypertrophic gastropathy who had in addition a low pepsinogen A:C ratio (< 1.6). Patients with achlorhydria, hypertrophic gastropathy, or after total gastrectomy fell into an aberrant category. From this study we conclude that measurement of serum pepsinogen A and C and calculation of their ratio yield information useful for differentiation of gastric abnormalities.
Biemond
I
I
Dept. of Gastroenterology, University Hospital, Leiden, The Netherlands.
Kreuning
J
J
Jansen
J B
JB
Lamers
C B
CB
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D013272:Stomach Diseases / Q000175:diagnosis* / Q000601:surgery
D015415:Biomarkers; D010435:Pepsinogens