Associations between HLA frequencies and pathogenic features of human immunodeficiency virus type 1 infection in seroconverters from the Amsterdam cohort of homosexual men.
HLA-disease associations may be important for understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. Therefore, 106 homosexual men from the Amsterdam Cohort Study on AIDS with a known date of HIV-1 seroconversion were serologically typed for HLA. Several significant associations between HLA type and pathogenic features of HIV-1 infection were observed: Subjects with fever and skin rash during primary HIV-1 infection showed an increased frequency of HLA-B62 (relative risk [RR], 5.8; P = .005). The frequency of HLA-B35 was increased in subjects with a rapid decline in CD4+ T lymphocytes (RR, 3.2; P = .021). Kaplan-Meier survival analysis revealed a significant association between HLA-B35 and a decrease in CD4+ cells to < 200/microL (P = .01). The strongest association was found between HLA-DR1 and AIDS-related Kaposi's sarcoma (RR, 22.5; P < .001), also confirmed in survival analysis (P = .001). In AIDS patients with only opportunistic infections, increased frequencies of HLA-DR3 (P = .011) and -DQ2 (P = .007) were observed. Finally, the occurrence of syncytium-inducing HIV-1 variants was significantly associated with HLA-DQ2 (P = .01).
Klein
M R
MR
Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam.
Keet
I P
IP
D'Amaro
J
J
Bende
R J
RJ
Hekman
A
A
Mesman
B
B
Koot
M
M
de Waal
L P
LP
Coutinho
R A
RA
Miedema
F
F
D015331:Cohort Studies; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology*; D015497:HIV-1 / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006716:Homosexuality; D006801:Humans; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010641:Phenotype
D006680:HLA Antigens