In vivo activity of ajoene against rodent malaria.
Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model. A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there were no obvious acute toxic effects from the tested dose. The combination of ajoene (50 mg/kg) and chloroquine (4.5 mg/kg), given as a single dose on the day of the infection, completely prevented the subsequent development of parasitemia in treated mice.
Perez
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HA
Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
De la Rosa
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M
Apitz
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D000818:Animals; D002738:Chloroquine / Q000494:pharmacology / Q000633:toxicity; D004220:Disulfides / Q000494:pharmacology* / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010962:Plasmodium berghei / Q000187:drug effects; D013454:Sulfoxides
D004220:Disulfides; D010936:Plant Extracts; D013454:Sulfoxides; D002738:Chloroquine; C048980:ajoene