[Molecular mechanisms controlling cellular proliferation in the vascular system].
Molecular biological techniques and the study of models allowing elementary analysis have helped to identify the molecular mechanisms controlling cellular proliferation, products of oncogenes and anti-oncogenes and the proteins interacting with these compounds, or the elements of the cytoplasmic clock which controls the cellular cycle. However, analysis of model systems does not always correspond to what happens in vivo where a regulating molecule may have several functions and where certain controls are superfluous. Therefore, the angiogenic factors identified by their action on endothelial cells in vitro and in model systems in vivo are multifunctional molecules. Their expression and that of their receptors are not always associated with angiogenesis in normal or pathological conditions. Similarly, the responses of endothelial cells to these angiogenic factors are not the same in vivo and in culture plates. The authors discuss in more detail the role of the C-ets-1 oncogene which expresses itself in endothelial cells during angiogenesis. The C-ets-1 protein is a transcription factor which may control the expression of genes coding proteases which degrade the extracellular matrix. The description of the role of this molecule in the network controlling angiogenesis should enable the definition or evaluation of therapeutic actions targetting this process.
Vandenbunder
B
B
CNRS URA 1160, Institut Pasteur, Lille.
D002468:Cell Physiological Phenomena; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009857:Oncogenes / Q000502:physiology
D016228:Endothelial Growth Factors; D005346:Fibroblast Growth Factors
Mécanismes moléculaires contrôlant la prolifération cellulaire dans le système vasculaire.