[Severe rhabdomyolysis in a patient receiving lovastatin, danazol, and doxycycline].
Combinations of lovastatin and other drugs have been reported to cause rhabdomyolysis and myoglobinuria. The authors report such a case in a 72-year-old man who had been receiving atenolol, acetylsalicylic acid (ASA), dipyridamole, lovastatin, danazol, prednisone and doxycycline. The ASA, lovastatin and danazol were discontinued. The symptoms resolved, and laboratory test results were normal within 2 weeks. Lovastatin was strongly suspected; danazol was the most likely potentiator by diminishing the metabolism of lovastatin and its metabolites in the liver or by having a direct toxic effect on the muscles.
Dallaire
M
M
Département de médecine interne, Centre hospitalier Rouyn-Noranda, Qué.
Chamberland
M
M
D000368:Aged; D003613:Danazol / Q000009:adverse effects*; D004318:Doxycycline / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008148:Lovastatin / Q000009:adverse effects*; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced*
D008148:Lovastatin; D004318:Doxycycline; D003613:Danazol
Rhabdomyolyse sévère chez un patient recevant lovastatine, danazol et doxycycline.