title: Heparin-coated cardiopulmonary bypass circuits.
abstract: The indications for heparin-coated extracorporeal circuits cannot be defined or limited at present. Clinical investigation remains at an early stage of development. In situations where the risk of systemic anticoagulation is high, this technology would seem to hold great promise. Examples include extracorporeal lung assist and resuscitation from accidental hypothermia. Some have also suggested the use of heparin-coated circuits for percutaneous bypass in cardiopulmonary resuscitation. A significant advantage might also accrue in noncardiac surgical procedures requiring cardiopulmonary bypass, such as complex cerebral aneurysm or arteriovenous malformation resections, resections of the tracheal carina, or bilateral lung transplantations. Its role in routine cardiac surgical procedures remains uncertain, but the work of von Segesser et al suggests a need for continued investigation in that setting using reduced levels of systemic anticoagulation. That endeavor will be greatly assisted by the recent development of heparin-coated cardiotomy reservoirs. Although heparin-coated circuits have been safely used for extracorporeal lung assist with little or no systemic anticoagulation, prospective studies are clearly needed to determine if this approach is advantageous, and it would seem appropriate to develop heparin coating for silicone-based membrane oxygenators.
authors.affiliation: Department of Anesthesia, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.
authors.forename: G P
authors.initials: GP
authors.lastname: Gravlee
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D004867:Equipment Design; D005112:Extracorporeal Circulation / Q000295:instrumentation; D006493:Heparin / Q000737:chemistry; D006801:Humans; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D006493:Heparin