title: [Standardized infection model for the study of bony ingrowth dynamics of hydroxyapatite-coated and uncoated pure titanium mesh in swine femur].
abstract: The authors studied the ingrowth dynamics of bone tissue into the pores of Hydroxyapatite-coated (plasma-spraying technique) and uncoated wiremeshs of pure titanium in an infected implantation site. Samples of the tested materials were implanted into the femora of 15 adult Göttingen minipigs. Just before implantation they were contaminated with Staphylococcus aureus. The animals were sacrificed after 4, 8, 12 and 24 weeks. Undecalcified ground-sections of bone tissue were prepared (app. 100 microns) and stained with toluidine blue for comparative histological evaluation. The HA-coated implants demonstrated advanced new bone formation already after 4 weeks and nearly complete osseointegration after 12 weeks although all samples showed gross and histological signs of persisting infection. Comparable reactions of the uncoated implants could only be observed after 24 weeks. Signs of degradation of the Hydroxyapatite-coating could be seen in contact to soft tissue and were more extensive compared to the behaviour in an uninfected site. The results and possible clinical consequences are discussed.
authors.affiliation: Orthopädische Klinik, Philipps-Universität Marburg.
authors.forename: A
authors.initials: A
authors.lastname: Wilke
authors.forename: J
authors.initials: J
authors.lastname: Orth
authors.forename: M
authors.initials: M
authors.lastname: Kraft
authors.forename: P
authors.initials: P
authors.lastname: Griss
mesh_terms: D000818:Animals; D001846:Bone Development; D004195:Disease Models, Animal; D017886:Durapatite; D005260:Female; D005269:Femur / Q000601:surgery; D016348:Osseointegration; D016459:Prosthesis-Related Infections / Q000503:physiopathology*; D013203:Staphylococcal Infections / Q000503:physiopathology; D013526:Surgical Mesh; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium
chemical_list: D017886:Durapatite; D014025:Titanium
vernacular_title: Standardisiertes Infektmodell zur Untersuchung des knöchernen Einwachsverhaltens hydroxylapatit-beschichteter und unbeschichteter Reintitangitternetze am Schweinefemur.