Diagnostic value of estimated volumetric bone mineral density of the lumbar spine in osteoporosis.
Bone mineral density (BMD) measurements by dual-energy x-ray absorptiometry (DXA) are planar measurements. By measuring planar BMD in anteroposterior (AP) and lateral projections, it is possible to estimate the volumetric BMD by assuming that the vertebral body is an ellipsoid cylinder. Correction for the third dimension could improve the diagnostic accuracy of spinal BMD measurement in osteoporosis. The aims of this study were (1) to determine the effect of aging on volumetric BMD compared to planar measurements; and (2) to evaluate the diagnostic accuracy of volumetric BMD in comparison to planar measurements. We studied 26 postmenopausal women with osteoporotic vertebral fractures and 114 age- and sex-matched controls without vertebral fractures from a population-based group. AP and lateral decubitus BMD of the lumbar spine were measured by DXA using a Lunar DPX (precision error for AP measurement, 0.8%; for lateral measurement of vertebra L3, 6.4%). Between the ages of 51 and 85 years the decreases in volumetric BMD of L3 (vol L3), lateral BMD of L3 (lat L3), AP BMD of L3 (AP L3), and AP BMD of L2-4 (AP L2-4) were 31, 28, 17, and 17%, respectively. The decrease in BMD compared to controls in the osteoporotics for vol L3, lat L3, AP L3, and AP L2-4 were 31, 34, 23, and 23%; expressed as Z scores, the decreases were -1.36, -1.33, -1.46, and -1.47 standard deviation units. The areas under ROC analysis curves for vol L3, lat L3, AP L3, and AP L2-4 were 85, 86, 87, and 87%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Peel
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NF
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, England.
Eastell
R
R
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis*; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis*; D015203:Reproducibility of Results; D016103:Spinal Fractures