The effect of oral anticoagulant therapy on APTT results from a bedside coagulation monitor.
OBJECTIVE
The Ciba Corning 512 coagulation monitor (CC512) can be used to monitor heparin therapy by performing an activated partial thromboplastin time (APTT) at the patient's bedside. This study was designed to compare the CC512 results to results using the laboratory system. The relative sensitivities of both systems to the effect of oral anticoagulant therapy also was investigated.


METHODS
Activated partial thromboplastin times were performed with both the CC512 and laboratory system on 74 specimens from patients receiving i.v. heparin therapy, and on 14 specimens from patients on warfarin only. Heparin assays were performed on 43 of the specimens from the heparinized patients.


RESULTS
When a patient was receiving heparin only, the APTT results of the CC512 proved to be similar to existing laboratory methods. The CC512 APTT results of patients on warfarin only were markedly prolonged, whereas the laboratory APTTs were only slightly affected.


CONCLUSIONS
The CC512 results were comparable to the laboratory system. However, the CC512 APTT was more sensitive to the effect of warfarin than the laboratory APTT system used in this study. CC512 APTT results on a patient receiving both oral and intravenous anticoagulation could be misleading.
Ray
M J
MJ
Department of Pathology, Prince Charles Hospital, Brisbane, Queensland, Australia.
Carroll
P A
PA
Just
S J
SJ
Hawson
G A
GA
Bett
J H
JH
D000284:Administration, Oral; D001777:Blood Coagulation / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D010314:Partial Thromboplastin Time; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D006493:Heparin