Inhibitory effects of estrogen on stimulated salt appetite in rats.
Adult male rats consumed 50-150% more 0.5 M NaCl solution than females did during a 7-hr drinking test when robust salt appetite was elicited by dietary sodium deprivation for 8 days, daily injections of deoxycorticosterone, or adrenalectomy followed by 2 days of sodium deprivation. In contrast, male rats drank much less saline after systemic treatment with the natriuretic agent furosemide, adrenalectomy followed by 1 day of sodium deprivation, or sc treatment with colloid solution after 2 days of sodium deprivation, and female rats drank comparably small volumes. Conversely, 30-day-old prepubescent male and female rats showed equally robust salt appetites after 8 days of sodium deprivation. These and other findings support an inhibitory role of estrogen on salt appetite in rats, which appears to occur only when the appetite is especially pronounced.
Scheidler
M G
MG
Department of Behavioral Neuroscience, University of Pittsburgh, 15260.
Verbalis
J G
JG
Stricker
E M
EM
D000818:Animals; D001066:Appetite / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D008297:Male; D008901:Mineralocorticoids / Q000502:physiology; D009318:Natriuresis / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D010052:Ovariectomy; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012737:Sex Factors; D012741:Sexual Maturation / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*
D004967:Estrogens; D008901:Mineralocorticoids; D012462:Saline Solution, Hypertonic