[Physiopathological and therapeutic values of experimental model of acute otitis media. Review of the literature].
The animal model of acute otitis media (AOM) has been widely used to study the pathophysiology and treatment of this disease. Different authors have demonstrated a both mechanic and immunologic role of concomitant viral infection in the pathogenesis of AOM. The specific immune response was found mainly local in otitis media due to S. pneumoniae and systemic with H. influenzae. Local and systemic complications are currently precise. This model was proved useful in pre-clinical evaluation of antimicrobial agents and development of vaccines.
Barry
B
B
Institut National de la Santé et de la Recherche Médicale, Hôpital Claude Bernard, Paris.
Muffat-Joly
M
M
Gehanno
P
P
Pocidalo
J J
JJ
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D004710:Endolymph / Q000382:microbiology; D006168:Guinea Pigs; D018073:Haemophilus Vaccines / Q000627:therapeutic use; D006193:Haemophilus influenzae / Q000472:pathogenicity; D010033:Otitis Media / Q000382:microbiology / Q000503:physiopathology* / Q000628:therapy; D051381:Rats; D013296:Streptococcus pneumoniae / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D018073:Haemophilus Vaccines
Intérêts physiopathologiques et thérapeutiques du modèle expérimental d'otite moyenne aiguë. Revue de la littérature.