[CSF-1 (colony stimulating factors 1) and CSF-1 receptor. General review and expression in invasive breast tumors].
CSF-1 (colony stimulating factor-1), initially considered to be a monocyte specific growth and differentiation factor [4], has recently been shown to be produced in human endometrium [16], placenta [7], as well as in numerous solid tumors [19-23, 26, 27]. The CSF-1 receptor (a protein product of c-fms) [24] is a member of the tyrosine kinase receptor family and an autocrine or paracrine mechanism of activation has been suggested. Overactivation of this receptor can lead to a malignant phenotype in various cell systems [20, 21]. We review the biology of CSF-1 and fms expression in normal as well as in malignant tissues with particular reference to a potential role for CSF-1 in breast tumour invasion.
Beuvon
F
F
Laboratoire d'anatomopathologie, hôpital Sainte-Anne, Paris, France.
Palud
C
C
Tang
R
R
de la Rochefordière
A
A
Kheirallah
S
S
Pouillart
P
P
Scholl
S M
SM
D000230:Adenocarcinoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D003115:Colony-Stimulating Factors / Q000502:physiology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D016184:Receptors, Colony-Stimulating Factor / Q000502:physiology*
D003115:Colony-Stimulating Factors; D016184:Receptors, Colony-Stimulating Factor
CSF-1 (colony stimulating factor 1) et récepteur du CSF-1. Revue générale et expression dans les tumeurs mammaires invasives.