The clinical biochemistry of experimentally produced lupinosis in the sheep.
Lupinosis was produced in sheep in four experiments by administering a toxic extract of Phomopsis leptostromiformis by various routes and at various dose rates. The course of the intoxication was followed by plasma biochemical analyses for a number of electrolytes, metabolites and enzymes. Results from these analyses suggested that in addition to being an hepatotoxicity, lupinosis also resulted in injury to muscle, kidney and adrenal cortex. This was confirmed by microscopic examination of these tissues.
Allen
J G
JG
Animal Health Laboratories, Department of Agriculture, South Perth, Western Australia.
Randall
A G
AG
D000284:Administration, Oral; D000302:Adrenal Cortex / Q000187:drug effects; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D001798:Blood Proteins / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood; D007887:Fabaceae / Q000382:microbiology*; D005260:Female; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D003904:Mitosporic Fungi / Q000737:chemistry*; D009132:Muscles / Q000187:drug effects; D009183:Mycotoxins / Q000008:administration & dosage / Q000506:poisoning / Q000633:toxicity*; D010939:Plant Poisoning / Q000097:blood / Q000662:veterinary*; D010946:Plants, Medicinal; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*; D009842:Oligopeptides
D001663:Bilirubin; D001798:Blood Proteins; D003402:Creatine Kinase; D004573:Electrolytes; D004798:Enzymes; D009183:Mycotoxins; C035753:phomopsin; D009842:Oligopeptides