Fungal metabolites. Part 14. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia.
Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.
Sasaki
S
S
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Hashimoto
R
R
Kiuchi
M
M
Inoue
K
K
Ikumoto
T
T
Hirose
R
R
Chiba
K
K
Hoshino
Y
Y
Okumoto
T
T
Fujita
T
T
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004537:Eicosanoic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D003904:Mitosporic Fungi / Q000378:metabolism*; D013237:Stereoisomerism
D000935:Antifungal Agents; D004537:Eicosanoic Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D007166:Immunosuppressive Agents; C087463:mycestericin B; C087462:mycestericin A; C087465:mycestericin D; C087464:mycestericin C; C001996:thermozymocidin