The effects of itraconazole on the immune responses in ICR mice.
Effects of itraconazole (ICZ) on the immune responses were studied in ICR mice. Mice were divided into 5 groups (10 mice/group), and ICZ at doses of 10, 20, 40 and 80 mg/kg were orally administered to mice once a day for 21 days. Mice were immunized and challenged with sheep red blood cells (SRBC). The body weight gains and the relative weights of spleen and thymus were dose-dependently increased following ICZ treatment. However, Plaque forming cells (PFC) and hemagglutination (HA) titers to SRBC were significantly suppressed in mice doses at 80 mg/kg ICZ, as compared with those in controls. Delayed-type hypersensitivity (DTH) reaction to SRBC, phagocyte activity and circulating leukocytes also were significantly decreased in mice dosed at 40 and 80 mg/kg ICZ. These studies demonstrate that ICZ treatment results in a marked suppression in both humoral and cell-mediated immune responses to SRBC at concentrations producing embryotoxicity.
Kim
J H
JH
Center for Food and Drug Safety, Won Kwang University, Iri, Chunrabuk-Do, Korea.
Ahn
Y K
YK
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D006386:Hemagglutination Tests; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007114:Immunization; D017964:Itraconazole / Q000633:toxicity*; D007958:Leukocyte Count / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D010586:Phagocytes / Q000187:drug effects; D012756:Sheep / Q000276:immunology
D017964:Itraconazole