Ozone-induced inflammation and altered ventilation in genetically susceptible mice: a comparison of acute and subacute exposures.
We have examined whether the effects of acute (2 ppm/3 h) and subacute (0.3 ppm/72 h) ozone (O3) exposures on airways are mutually predictive. Inbred C57BL/6J (susceptible) and C3H/HeJ (resistant) mice are differentially responsive to inflammation induced by the 2 exposures. Breeding experiments and cosegregation analysis indicated that 2 separate genes control inflammatory responses: Inf (acute), Inf-2 (subacute). The genetic model was also used to examine the effects of both exposures on the magnitude and pattern of breathing. Results imply that mechanisms that control susceptibility to the 2 exposures are not the same, and that one response is not necessarily predictive of the other.
Tankersley
C G
CG
Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Baltimore, MD 21205.
Kleeberger
S R
SR
D000818:Animals; D001991:Bronchitis / Q000139:chemically induced* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010126:Ozone / Q000633:toxicity*; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology; D011237:Predictive Value of Tests; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors; D014136:Tracheitis / Q000139:chemically induced* / Q000473:pathology
D010126:Ozone