Neonatal plasma vitamin K1 levels following oral and intramuscular administration of vitamin K1.
Vitamin K1 levels were measured by high performance liquid chromatography in cord blood (n = 33) and at the age of 97-120 h after administration of 2 mg of vitamin K1 orally (n = 88) or 1 mg of vitamin K1 by im injection (n = 88). Vitamin K1 levels were less than 0.05 micrograms/l in cord blood. The mean (range), SEM, mode and median values (micrograms/l) for the infants given oral vitamin K1 were 17.99 (1-56), 1.25, 8 and 15.5 and those for the infants given im vitamin K1 15.83 (2-57), 1.01, 11 and 14, respectively. The t-test showed no significant difference in the mean values (p = 0.09) in the infants given oral or im vitamin K.
Gupta
J M
JM
Royal Hospital for Women, Sydney, Australia.
Salonikas
C
C
Naidoo
D
D
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D010837:Vitamin K 1 / Q000008:administration & dosage* / Q000097:blood*; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
D010837:Vitamin K 1