title: [Left ventricular hypertrophy: molecular aspects].
abstract: The expression of genes changes during left ventricular hypertrophy. These changes are known as mechanogenic transduction. With respect to the two main contractile proteins, myosin and actin, this is due to a differential expression of their respective multigenic families. Changes of isoform are uncoordinated in time and space. It is important to recognise that the genes themselves are normal and that it is their regulation which is disturbed. Recent data shows that, under normal conditions, the regulation occurs at the transcription stage. A fuller understanding of these mechanisms is necessary if we are to comprehend the pathogenesis of cardiac hypertrophy and failure.
authors.affiliation: INSERM Unité 127, hôpital Lariboisière, Paris.
authors.forename: K
authors.initials: K
authors.lastname: Schwartz
authors.forename: C
authors.initials: C
authors.lastname: Chassagne
authors.forename: L
authors.initials: L
authors.lastname: Carrier
authors.forename: K R
authors.initials: KR
authors.lastname: Boheler
mesh_terms: D000199:Actins / Q000235:genetics* / Q000502:physiology; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000235:genetics* / Q000503:physiopathology; D009218:Myosins / Q000235:genetics* / Q000502:physiology
chemical_list: D000199:Actins; D009218:Myosins
vernacular_title: Hypertrophie ventriculaire gauche: aspects moléculaires.