[Hereditary predisposition for cancer of the breast and the ovary].
Familial breast cancers represent about 10% of all cases of breast cancers. A predisposition locus has been located in the 17q21 chromosomal region. Nineteen French breast and breast-ovarian cancer families were tested for linkage with five highly polymorphic 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer families do not. Heterogeneity of linkage of familial breast cancer is significant in France and supports the existence of more than one susceptibility gene.
Lalle
P
P
Laboratoire d'oncologie moléculaire, centre Jean-Perrin, Clermont-Ferrand, France.
Stoppa-Lyonnet
D
D
Mazoyer
S
S
Rio
P
P
Girodet
C
C
Hardouin
A
A
Narod
S A
SA
Sobol
H
H
Bignon
Y J
YJ
D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008126:Lod Score; D008593:Menopause; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree
Prédisposition héréditaire aux cancers du sein et de l'ovaire.