title: A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo.
abstract: Chromosome 16 aberrations are well known in acute nonlymphocytic leukemia (ANLL). The most frequent chromosome 16 aberration in ANLL subtype M4Eo is the inv(16)(p13q22). Recently, we showed that in 5 inv(16) patients with ANLL M4Eo the short arm breakpoints are clustered within a 14-kb genomic EcoRI fragment. We report here the identification of a gene situated in the 14-kb fragment. The gene, which codes for a myosin peptide, is disrupted by the inversion of chromosome 16 in the 5 patients. To the best of our knowledge, this is the first report of a myosin gene disrupted in leukemia.
authors.affiliation: Department of Human Genetics, Leiden University, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: van der Reijden
authors.forename: J G
authors.initials: JG
authors.lastname: Dauwerse
authors.forename: J W
authors.initials: JW
authors.lastname: Wessels
authors.forename: G C
authors.initials: GC
authors.lastname: Beverstock
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: G J
authors.initials: GJ
authors.lastname: van Ommen
authors.forename: M H
authors.initials: MH
authors.lastname: Breuning
mesh_terms: D001483:Base Sequence; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000737:chemistry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D009218:Myosins / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D009218:Myosins