title: [Decreased interleukin-1 and interleukin-2 production after splenectomy].
abstract: Production of interleukin-1 and of interleukin-2 was measured in 57 splenectomized patients. 11 of them were after elective operations (aged 14-37 years, mean 24) and 46 posttraumatic (aged 20-36, mean 23) and in 20 appropriate controls. There was significant reduction of both interleukins in the splenectomized group, more evident in the elective group. The deficiency was not related to age of patient or time since splenectomy. These results support the view that a consequence of splenectomy is immunoregulatory deficit.
authors.affiliation: Leon Alcalay Chair in Pediatric Immunology, Tel Aviv University.
authors.forename: Z
authors.initials: Z
authors.lastname: Spirer
authors.forename: R
authors.initials: R
authors.lastname: Arav-Boger
authors.forename: V
authors.initials: V
authors.lastname: Zakuth
authors.forename: E
authors.initials: E
authors.lastname: Tzehoval
authors.forename: S
authors.initials: S
authors.lastname: Dagan
authors.forename: B
authors.initials: B
authors.lastname: Lev
authors.forename: A
authors.initials: A
authors.lastname: Golander
authors.forename: I
authors.initials: I
authors.lastname: Melamed
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D013156:Splenectomy; D013997:Time Factors
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2