title: Reducing the loss of implants following penile prosthetic surgery.
abstract: OBJECTIVE
  To assess the factors associated with loss of implant following penile prosthetic surgery and to make alterations in the management of patients to prevent this from occurring.
  
  
  METHODS
  A retrospective analysis was carried out of the factors associated with post-operative infection and erosion in 188 patients who underwent implantation of penile prostheses. A prospective study was then established in which 62 patients were managed by a set protocol designed to counteract the factors identified as being contributory to loss of implants in the retrospective review.
  
  
  RESULTS
  In the retrospective study nine (4.8%) patients lost a prosthesis due to erosion. Erosion was noted to be more common with one type of implant which has since been modified. Infection was the cause of prosthesis loss in 12.2% of patients in the retrospective review. The new protocol resulted in a significantly reduced infection rate in penile prostheses to 1.6% (P < 0.05).
  
  
  CONCLUSIONS
  With attention to simple antiseptic prophylaxis, antibiotic penetration and continuing audit, a significant improvement in the loss of penile prostheses can be achieved along with a reduction in the amount of antibiotics prescribed.
authors.affiliation: Institute of Urology and Nephrology, University College Hospital, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lynch
authors.forename: G M
authors.initials: GM
authors.lastname: Scott
authors.forename: J A
authors.initials: JA
authors.lastname: Inglis
authors.forename: J P
authors.initials: JP
authors.lastname: Pryor
mesh_terms: D000328:Adult; D002444:Cefuroxime / Q000008:administration & dosage / Q000493:pharmacokinetics; D002985:Clinical Protocols; D007172:Erectile Dysfunction / Q000209:etiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015917:Penile Prosthesis / Q000009:adverse effects*; D011446:Prospective Studies; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002444:Cefuroxime