[Essentiale as an inducer of immunomodulating properties in erythrocytes].
The erythrocytes extracorporeally treated with essentiale have a property to stimulate an immune response to T-dependent antigen, but fail to affect the extent of the immune response induced by T-independent antigen. The treatment of essentiale induces the appearance of immunostimulating properties in a fraction of heavy (over 1.117) erythrocytes, but does not influence the properties of light (under 1.079) and intermediate (1.092-1.105) erythrocytes. The essentiale-modified heavy erythrocytes induce intact rat splenic cell adherent to the glass to release the factor that stimulates an immune response to T-dependent antigen and the factor that induces the appearance of immunosuppressor properties of light erythrocytes.
Uteshev
B S
BS
Laskova
I L
IL
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000955:Antigens, T-Independent / Q000276:immunology; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology*; D007114:Immunization / Q000379:methods; D008070:Lipopolysaccharides / Q000276:immunology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D000955:Antigens, T-Independent; D008070:Lipopolysaccharides; D010713:Phosphatidylcholines; C011246:essential 303 forte
Essentsiale kak induktor immunomoduliruiushchikh svoĭstv u éritrotsitov.