Genetics of signal transduction in invertebrates.
Receptor tyrosine kinases regulate a number of different cell fate decisions during invertebrate development. Genetic analysis of the signal transduction pathways activated by these kinases suggests that they converge upon a common pathway involving Ras and a cascade of cytoplasmic kinases, diverging again in the nucleus with the regulation of specific transcription factors.
Dickson
B
B
Zoologisches Institut, Universität Zürich, Switzerland.
Hafen
E
E
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D011905:Genes, ras; D007448:Invertebrates / Q000235:genetics* / Q000502:physiology*; D008969:Molecular Sequence Data; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics*
D020794:Receptor Protein-Tyrosine Kinases