Activity oscillations predicted for pyruvate dehydrogenase complexes.
A kinetic model for the pyruvate dehydrogenase complex is analyzed. The model takes into account intermediate channeling through the lipoyl network attached to the complex core, as well as inter-related regulatory effects of protein X acetylation and enzyme phosphorylation. The model predicts undamped oscillations of enzyme activity.
Selivanov
V A
VA
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region.
Zakrzhevskaya
D T
DT
Goldstein
B N
BN
D007700:Kinetics; D008433:Mathematics; D008962:Models, Theoretical; D009991:Oscillometry; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D013997:Time Factors
D011768:Pyruvate Dehydrogenase Complex