[Mechanisms of the beneficial effect of indomethacin and nimodipine in the treatment of traumatic shock in rats].
Aiming to study the pathogenetic mechanisms of the disturbed function of the central nervous system in traumatic shock we have determined the dynamics of changes of eicosanoids (PGF2 alpha, TxB2, 6-keto-PGF1 alpha, peptidoleukotrienes) in the brain structures (medulla oblongata, hypothalamus) of the experimental animals subjected to bilateral trauma of the hind legs (tourniquet trauma, LD50). Considering that our previous data have shown the importance of eicosanoid mediatory system in the pathogenetic mechanisms of shock, we have studied possible use of prostaglandin synthesis inhibitors (indomethacin) and calcium channel antagonists (nimidipine) in traumatic shock. The authors have concluded that in the pathogenetic mechanism of the disturbed function of the CNS in traumatic shock the important role has peptidoleukotrienes as well as that the combined use of prostaglandin synthesis inhibitors and antagonists of voltage-dependent calcium channel would be useful in the therapy of the injured patients.
Cernak
I
I
Vojnomedicinska akademija, Institut za medicinska istrazivanja.
Savić
J
J
Marković
M
M
Selaković
V
V
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D001921:Brain / Q000378:metabolism; D015237:Dinoprost / Q000096:biosynthesis; D007213:Indomethacin / Q000627:therapeutic use*; D015289:Leukotrienes / Q000096:biosynthesis; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013929:Thromboxane B2 / Q000096:biosynthesis
D015289:Leukotrienes; D013929:Thromboxane B2; D009553:Nimodipine; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D007213:Indomethacin
Mehanizmi povoljnog efekta indometacina i nimodipina u lecenju traumatskog soka kod pacova.