Differential expression of Fos protein in the brain of female mice dependent on pup sensory cues and maternal experience.
Immunoreactivity for Fos protein following 30 min of sensory and behavioral experience with foster pups was measured in different brain areas of nulliparous female Balb/c mice who were intact, ovariectomized, or selectively depleted of olfactory bulb noradrenaline. Fos expression was also investigated in intact nulliparous female mice undergoing distal exposure to pup sensory cues. Behavioral interaction with pups increased Fos immunoreactivity in the olfactory areas (anterior olfactory nucleus, piriform cortex, corticomedial amygdala, and entorhinal cortex) as well as in the medial preoptic area, and this occurred regardless of whether females were intact or ovariectomized. Noradrenaline depletion of the olfactory bulb prevented Fos induction in primary olfactory areas, but not in the medial preoptic area, whereas distal exposure to pup cues enhanced Fos expression in the olfactory areas but not in the medial preoptic area.
Calamandrei
G
G
Reparto di Fisiopatologia Comportamentale, Laboratorio di Fisiopatologia, Istituto Superiore di Sanità, Rome, Italy.
Keverne
E B
EB
D000679:Amygdala / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D004967:Estrogens / Q000502:physiology; D005260:Female; D007124:Immunoenzyme Techniques; D008032:Limbic System / Q000502:physiology; D008297:Male; D008425:Maternal Behavior; D051379:Mice; D008807:Mice, Inbred BALB C; D009638:Norepinephrine / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology*; D009833:Olfactory Pathways / Q000502:physiology; D010052:Ovariectomy; D011301:Preoptic Area / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D012683:Sensory Deprivation / Q000502:physiology; D012903:Smell / Q000502:physiology*; D012931:Social Environment
D004967:Estrogens; D016760:Proto-Oncogene Proteins c-fos; D009638:Norepinephrine