Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.
The effects of chelating agent treatment with meso-2,3-dimercaptosuccinic acid (DMSA), Na2CaEDTA, Na2ZnEDTA, and Na3ZnDTPA on the organ lead levels of lead-loaded mice have been determined. At 1 mmol/kg/day i.p., all caused reductions in the lead levels of the kidney after four injections, but only Na2CaEDTA produced a significant reduction in brain lead. All chelating agents caused significant reductions in kidney and brain lead levels when administered at a daily dose of 1 mmol/kg/day for eight days, but only DMSA reduced the bone lead level. In animals given 50 mg Pb/kg or 100 mg Pb/kg, the administration of Na2CaEDTA or DMSA at 1 mmol/kg/day x 8 produced significant reductions in kidney, bone and brain lead levels, but DMSA produced greater reductions of bone lead in both groups and of kidney lead in the group given 100 mg Pb/kg. An examination of published data describing the effect of chelating agent treatment on brain lead levels indicates that DMSA produces a reduction in brain lead levels under all conditions examined to date.
Jones
M M
MM
Department of Chemistry, Vanderbilt University, Nashville, TN 37235.
Basinger
M A
MA
Gale
G R
GR
Atkins
L M
LM
Smith
A B
AB
Stone
A
A
D000818:Animals; D001842:Bone and Bones / Q000737:chemistry / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D002614:Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004492:Edetic Acid / Q000494:pharmacology / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000737:chemistry / Q000187:drug effects*; D007854:Lead / Q000032:analysis / Q000378:metabolism; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D004369:Pentetic Acid / Q000494:pharmacology / Q000627:therapeutic use; D013054:Spectrophotometry, Atomic; D004113:Succimer / Q000494:pharmacology / Q000627:therapeutic use
D002614:Chelating Agents; D007854:Lead; D004369:Pentetic Acid; D004492:Edetic Acid; D004113:Succimer