[Significance of platelet aggregation in patients with malignant tumor of the head and neck].
Platelet aggregation test (PAgT) was done in 492 patients with malignant tumor of the head and neck, and in 100 healthy adults and 33 patients with benign tumors of the head and neck. The results showed: (1) The maximum aggregation rate (MAR) of the pretreatment group, recurring group and distant metastasis group of the malignant tumor patients were significantly higher than that of healthy adults, benign tumor and posttreatment group of malignant tumor patients; (2) There was no significant difference between MAR of healthy adults and the patients with benign tumor of the head and neck; (3) MAR was enhanced as the tumor progress. The Results indicate that (1) Platelet aggregation in malignant tumor of the head and neck is enhanced; and (2) PAgT might be used as a reference index for the nature, development, effect of treatment and prognosis of tumors. The mechanisms of enhancement of platelet aggregation in malignant tumor, and the role of platelet in pathogenesis of proliferation and metastasis of tumors were also discussed. The clinical use of the platelet-inhibitory agents for anti-proliferation and metastasis of tumors was in prospect.
Nong
H T
HT
Affiliated Hospital of Guangxi Medical University, Nanning.
D000293:Adolescent; D000328:Adult; D000368:Aged; D018322:Angiofibroma / Q000097:blood / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000097:blood / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000097:blood / Q000473:pathology; D009367:Neoplasm Staging; D010974:Platelet Aggregation; D011379:Prognosis