title: Hematologic response of adult brown mink to oxidative stress.
abstract: We evaluated the response of mink to oral administration of the oxidant compound propylene glycol (PG) to better understand the relative susceptibility of mink red blood cells (RBC) to oxidant injury. Feeding a diet containing 12% PG to 6 mink for 1 w resulted in a 17% decrease in hematocrit, a 21% decrease in RBC count and a 4.8-fold increase in reticulocyte count. A marked increase in Heinz body and eccentrocyte numbers was consistent with oxidative injury to RBC. Because of high food intake, mink ingested approximately twice the quantity of PG/kg body weight compared to domestic cats fed diets containing 12% PG. Therefore, the severity of the hematologic dyscrasia in mink may be the result of greater intake of PG rather than unique sensitivity of mink RBC of oxidative injury. However, the high food intake and the mink's position at the top of the food chain may increase its exposure to environmental contaminants.
authors.affiliation: Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St Paul.
authors.forename: D J
authors.initials: DJ
authors.lastname: Weiss
authors.forename: V
authors.initials: V
authors.lastname: Perman
authors.forename: W
authors.initials: W
authors.lastname: Wustenberg
authors.forename: T J
authors.initials: TJ
authors.lastname: Bucci
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D006366:Heinz Bodies / Q000187:drug effects; D008297:Male; D008907:Mink / Q000097:blood*; D016877:Oxidants / Q000633:toxicity*; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000633:toxicity
chemical_list: D016877:Oxidants; D011409:Propylene Glycols; D019946:Propylene Glycol