title: Histamine as an intracellular messenger in human platelets.
abstract: The results of investigations in platelets provide evidence for an intracellular messenger role for histamine. Studies of neutrophils and of cellular proliferation suggest that there may be a wider role for histamine as an intracellular messenger modulating activation processes in cells.
authors.affiliation: Manitoba Institute of Cell Biology, Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Gerrard
authors.forename: S P
authors.initials: SP
authors.lastname: Saxena
authors.forename: A
authors.initials: A
authors.lastname: McNicol
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D002455:Cell Division; D004789:Enzyme Activation; D006402:Hematologic Diseases / Q000503:physiopathology; D006632:Histamine / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D015539:Platelet Activation / Q000187:drug effects; D011073:Polyamines / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: D006633:Histamine Antagonists; D011073:Polyamines; D006632:Histamine; D006640:Histidine Decarboxylase