Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa.
Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined. These results suggest that the compound selectively increases cerebral blood flow.
Haji
A
A
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Momose
Y
Y
Takeda
R
R
Nakanishi
S
S
Horiuchi
T
T
Arisawa
M
M
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D012129:Respiratory Function Tests
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; C028633:dehydroevodiamine