[Plasmatic concentrations of fluoxetine, pharmacokinetics, therapeutic response and side effects].
The kinetics of fluoxetine and possible relations between the drug's plasmatic concentration and therapeutic response and side effects were evaluated in a sample of 66 depressive patients, 26 men and 40 women, average age 46.6 years (SD = 14.1), diagnosed according to DSM-III criteria and evaluated using the Hamilton scale for depression (17-item HRSD). We found no difference between plasmatic concentration of fluoxetine in weeks 3 and 6 of treatment, nor in the sum of drug plus active principle in weeks 3 and 6. There was no significant linear correlation between plasmatic concentrations of fluoxetine, norfluoxetine, or the sum of both in weeks 3 and 6 and score on the Hamilton scale in week 6. By means of serial Chi-score calculation we found a "minimum plasmatic concentration" of about 30 ng/ml below which there was less therapeutic response.
Pérez Sola
V
V
Servicio de psiquiatría, Hospital de la Santa Creu y Sant Pau, Universidad de Bellaterra, Barcelona.
Pérez Blanco
J
J
Alvárez
E
E
Queralto
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000929:Antidepressive Agents, Tricyclic / Q000145:classification / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics*; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index
D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine
Niveles plasmáticos de fluoxetina: farmacocinética, respuesta terapeútica y efectos secundarios.