[The effect of a crown-ether derivative, ethmozine and etatsizin on the functioning of the calcium pools in the guinea pig myocardium].
Analysis of the component structure of single contractions of papillary muscles in guinea pigs was used to study the effects of the crown ether derivative benzylase-15-crown-5 and the antiarrhythmic agents ethmozine and ethacizine. The negative inotropic effect of these compounds was shown to be associated with limited penetration of calcium ions from the sarcolemmal pool into cardiac cellular myoplasm.
Bogomaz
S A
SA
Gurbanov
K G
KG
Paperno
A A
AA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D043844:Crown Ethers; D004988:Ethers, Cyclic / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D016293:Moricizine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology; D010640:Phenothiazines / Q000494:pharmacology*; D012508:Sarcolemma / Q000187:drug effects / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D015220:Calcium Channels; D043844:Crown Ethers; D004988:Ethers, Cyclic; D010640:Phenothiazines; D016293:Moricizine; C042148:15-crown-5; C058863:benzylaza-15-crown-5; C046818:ethacizine
Vliianie proizvodnogo kraun-éfira, étmozina i étatsizina na funktsionirovanie kal'tsevykh pulov v miokarde morskikh svinok.