Metabolic disposal of antipyrine and lipid peroxidation indices in volunteers jointly exposed to industrial organic solvents and ethanol.
Each of twelve volunteers, at 2 week intervals, received 1 g of antipyrine, a test drug, and were exposed for 4 h either to toluene (375 mg/m3) or xylene (435 mg/m3) singly or in combination with ethanol (0.45 g/kg body wt. before the onset of exposure and 0.15 g/kg thrice every 1 h during exposure to maintain a steady level of ethanol in blood approximately 11 mmol/dm3). No significant differences were found in salivary antipyrine half-life (T1/2 approximately 12 h); and clearance (ClAP approximately 0.83 cm3/s) between control and groups exposed to solvents and/or ethanol. Nevertheless, a tendency to increase the metabolic rate of antipyrine in xylene-exposed group (T1/2 approximately 6.8 h; ClAP approximately 1.40 cm3/s) and counteraction of ethanol (T1/2 approximately 15 h; ClAP approximately 0.63 cm3/s) should be noted. The stimulation of lipid peroxidation in the serum as a biological effect of combined exposure to ethanol and toluene/xylene was observed.
Wiśniewska-Knypl
J
J
Department of Biochemistry, Nofer Institute of Occupational Medicine, Lodz, Poland.
Jajte
J
J
Wrońska-Nofer
T
T
Kostrzewski
P
P
D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D012463:Saliva / Q000737:chemistry; D014050:Toluene / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D014992:Xylenes / Q000378:metabolism*
D014280:Triglycerides; D014992:Xylenes; D014050:Toluene; D000431:Ethanol; D000983:Antipyrine