Guillain-Barré syndrome after autologous bone marrow transplantation for breast cancer: report of two cases.
Guillain-Barré syndrome appeared in two patients following autologous bone marrow transplantation for metastatic breast cancer. In one case, the patient responded to plasmapheresis and became ambulatory. In the second case, the patient died of an unrelated complication: intracerebral hemorrhage. Although Guillain-Barré syndrome is associated with hematologic malignancies, it has not been previously reported in patients with solid tumors undergoing autologous bone marrow transplantation. Because both patients were in remission at the time of the autograft, Guillain-Barré syndrome may emerge as a rare complication of altered immune function and/or viral infection after marrow transplantation.
Myers
S E
SE
Bone Marrow Transplant Program, University of Chicago Medical Center, IL 60637.
Williams
S F
SF
D000230:Adenocarcinoma / Q000188:drug therapy / Q000628:therapy*; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007107:Immune System / Q000502:physiology; D008875:Middle Aged; D010956:Plasmapheresis; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000628:therapy; D014182:Transplantation, Autologous; D014777:Virus Diseases / Q000150:complications
D000970:Antineoplastic Agents