title: Does adequate patient selection reduce the risk of gallstone recurrence after successful extracorporeal shockwave lithotripsy?
abstract: To determine the risk of gallbladder stone recurrence in these patients, 58 of the first consecutive 61 patients with solitary stones achieving complete stone clearance after ESWL and adjuvant bile acid therapy were included in a prospective study. All patients were observed for at least 12 months following discontinuation of oral bile acids. Twenty-one patients fulfilled our postulated ideal criteria (solitary radiolucent stones between 10-20 mm initial diameter, initial stone density < 50 HU, gallbladder ejection fraction > 70%). The remaining patients (n = 37) fulfilled the criteria of the Munich study group. In patients fulfilling our ideal criteria, stone recurrence was not observed in any patient, while in those fulfilling solely the criteria of the Munich group, five instances of stone recurrence were observed (13.5% [n = 37], p < 0.1). Initial stone count is only one factor influencing the probability of gallstone recurrence following ESWL and discontinuation of oral bile acids. Our data suggest that factors such as low initial stone density at gallbladder CT and good gallbladder function not only accelerate initial stone clearance but also reduce the risk of stone recurrence after ESWL once oral bile acids have been discontinued.
authors.affiliation: Abteilung für Endokrinologie, Ernährungswissenschaft, Gastroenterologie und Stoffwechselkrankheiten, Universität Ulm.
authors.forename: W
authors.initials: W
authors.lastname: Kratzer
authors.forename: R A
authors.initials: RA
authors.lastname: Mason
authors.forename: P
authors.initials: P
authors.lastname: Janowitz
authors.forename: J
authors.initials: J
authors.lastname: Tudyka
authors.forename: C
authors.initials: C
authors.lastname: Maier
authors.forename: J G
authors.initials: JG
authors.lastname: Wechsler
authors.forename: G
authors.initials: G
authors.lastname: Adler
mesh_terms: D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000008:administration & dosage; D002769:Cholelithiasis / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D016473:Gallbladder Emptying / Q000187:drug effects; D006801:Humans; D008096:Lithotripsy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D001647:Bile Acids and Salts