title: The application of mitochondrial DNA typing to the study of white Caucasian genetic identification.
abstract: Mitochondrial DNA (mtDNA) from 100 unrelated British White Caucasians was extracted, amplified and directly sequenced. Sequences of approximately 800 nucleotides were obtained from 2 hypervariable segments within the non-coding region of the mitochondrial genome. A total of 91 different sequences were observed with an average nucleotide diversity of 1.1%. The most diverse pair of sequences differed at 3.6% of their nucleotide (nt) sites. Comparison to a consensus reference sequence showed that each region was polymorphic to a similar extent. Different methods of genetic analysis were used to examine the variation in each region, including pairwise comparisons, which demonstrated that although the data did not fit a Poisson distribution, the fit was closer to a Negative Binomial distribution.
authors.affiliation: Central Research and Support Establishment, Forensic Science Service, Reading, Berkshire, UK.
authors.forename: R
authors.initials: R
authors.lastname: Piercy
authors.forename: K M
authors.initials: KM
authors.lastname: Sullivan
authors.forename: N
authors.initials: N
authors.lastname: Benson
authors.forename: P
authors.initials: P
authors.lastname: Gill
mesh_terms: D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000235:genetics*; D004739:England; D005828:Genetics, Population; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014852:Wales; D044465:White People / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial