[Prostaglandin content in decidual tissue of women in spontaneous abortion].
Prostaglandins E2 and F2 alpha were measured in decidual tissue of women after spontaneous abortions at pregnancy terms 8 to 10 weeks and after abortions induced by sulprostone, a synthetic prostaglandin E2 analog, at pregnancy term 4-5 weeks. Women in whom pregnancy was terminated surgically at relevant periods were controls. Prostaglandin E2 concentration was found to be 5 times higher and that of prostaglandin F2 alpha 40 times higher in women with spontaneous abortions than in surgical abortion. In sulprostone-induced abortion prostaglandin concentrations in decidual tissue were the same as in controls. These data indicate that a drastic increase of prostaglandin levels in spontaneous abortion is not only a result of myometrial contractions or decidual tissue rejection, but an important component in the chain of events leading to miscarriage.
Morozova
M S
MS
Goncharova
V N
VN
Astakhova
T M
TM
Zaĭtseva
T S
TS
Manuilova
I A
IA
D000020:Abortifacient Agents, Nonsteroidal; D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000378:metabolism*; D003656:Decidua / Q000378:metabolism*; D015232:Dinoprostone / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism*
D000020:Abortifacient Agents, Nonsteroidal; D011453:Prostaglandins; C016767:sulprostone; D015232:Dinoprostone
Soderzhanie prostaglandinov v detsidual'noĭ tkani zhenshchin pri samoproizvol'nom aborte.