Biodegradable poly(DL-lactic acid) formulations in a calcitonin delivery system.
A synthetic analogue of eel calcitonin, [Asu1, 7]-ECT, was incorporated into biodegradable poly(DL-lactic acids) with number-average molecular weights (Mn) of 1400-4400 by the melt-pressing technique. The in vitro release of drug from a parabolically degradable poly(DL-lactic acid) with Mn = 1400 showed an initial burst release and completed the release in 3 d from the start of the test. The drug release from a Mn = 4400 polymer with an S-type degradation pattern was kept at 14 +/- 5 units/d for an experimental period of 24 d.
Asano
M
M
Department of Material Development, Japan Atomic Energy Research Institute, Gunma.
Yoshida
M
M
Omichi
H
H
Mashimo
T
T
Okabe
K
K
Yuasa
H
H
Yamanaka
H
H
Morimoto
S
S
Sakakibara
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001673:Biodegradation, Environmental; D002116:Calcitonin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004524:Eels; D007773:Lactates / Q000493:pharmacokinetics; D019344:Lactic Acid; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011091:Polyesters; D011108:Polymers / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D002116:Calcitonin; C012755:elcatonin