Cytomegalovirus colitis after 5-fluorouracil and interferon-alpha therapy.
Cytomegalovirus (CMV) infection is an opportunistic viral infection primarily affecting immunocompromised patients. Patients with inflammatory bowel disease have an increased risk for developing CMV infections of the gastrointestinal tract. While receiving continuous infusion of 5-fluorouracil and interferon-alpha, a 72-year-old woman with stage IV pancreatic carcinoma developed severe colitis with diarrhea that was refractory to conventional antidiarrheals. A biopsy specimen from the colon revealed CMV inclusions, which were confirmed by immunofluorescence. The patient was given ganciclovir 210 mg (5 mg/kg) every 12 hours for 14 days, and the diarrhea resolved after approximately 8 days of therapy. This is the first reported case of CMV colitis associated with combination 5-fluorouracil and interferon-alpha therapy.
Baker
J L
JL
Department of Pharmacy, Lucille P. Markey Cancer Center, Lexington, Kentucky.
Gosland
M P
MP
Herrington
J D
JD
Record
K E
KE
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003092:Colitis / Q000209:etiology* / Q000382:microbiology; D003586:Cytomegalovirus Infections / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D010190:Pancreatic Neoplasms / Q000188:drug therapy
D016898:Interferon-alpha; D015774:Ganciclovir; D005472:Fluorouracil