title: ICAM-3 expression on endothelium in lymphoid malignancy.
abstract: Intercellular adhesion molecule-3 (ICAM-3), the third receptor for lymphocyte function-associated antigen molecule-1 and a new member of the immunoglobulin superfamily has been recently characterized using specific monoclonal antibodies. In the present study, we show immunocytochemically that ICAM-3 is present on T and B cells in the mantle zones and on a subpopulation of follicular center cells in reactive lymph nodes and only occasionally in endothelium. In 52 cases of Hodgkin's disease, ICAM-3, although present on the majority of the reactive lymphoid cells, was absent from the Reed-Sternberg cells and their variants. However, in 28 cases (54%), there was prominent endothelial staining in small vessels. Similar findings were noted in 16 out of 49 cases (33%) of non-Hodgkin's lymphomas. This finding suggests that analogous to ICAM-1 and ICAM-2, ICAM-3 expression can be induced on endothelial cells in lymphoid neoplasms, probably by an as yet unidentified cytokine-mediated mechanism.
authors.affiliation: Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: I
authors.initials: I
authors.lastname: Doussis-Anagnostopoulou
authors.forename: L
authors.initials: L
authors.lastname: Kaklamanis
authors.forename: J
authors.initials: J
authors.lastname: Cordell
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: H
authors.initials: H
authors.lastname: Turley
authors.forename: K
authors.initials: K
authors.lastname: Pulford
authors.forename: D
authors.initials: D
authors.lastname: Simmons
authors.forename: D
authors.initials: D
authors.lastname: Mason
authors.forename: K
authors.initials: K
authors.lastname: Gatter
mesh_terms: D015703:Antigens, CD; D000943:Antigens, Differentiation; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D015815:Cell Adhesion Molecules; C483616:ICAM3 protein, human