Ifosfamide-induced nonconvulsive status epilepticus.
We report the first case of nonconvulsive status epilepticus as a complication of chemotherapy with the nitrogen mustard derivative ifosfamide. Our patient developed encephalopathy, upper extremity myoclonus, and a periodic, triphasic electroencephalogic pattern that resolved acutely with intravenous diazepam treatment. Since significant morbidity and mortality is associated with unrecognized status epilepticus, electroencephalogic monitoring and a trial of diazepam is indicated in encephalopathic patients with rhythmic electroencephalogic patterns while receiving treatment with ifosfamide.
Wengs
W J
WJ
Department of Neurology, University of Minnesota, Minneapolis.
Talwar
D
D
Bernard
J
J
D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D008875:Middle Aged; D013226:Status Epilepticus / Q000139:chemically induced* / Q000503:physiopathology
D007069:Ifosfamide