title: Decrease in cerebral inositols in rats and humans.
abstract: Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.
authors.affiliation: Huntingdon Medical Research Institutes, Pasadena, CA 91105.
authors.forename: R A
authors.initials: RA
authors.lastname: Moats
authors.forename: Y H
authors.initials: YH
authors.lastname: Lien
authors.forename: D
authors.initials: D
authors.lastname: Filippi
authors.forename: B D
authors.initials: BD
authors.lastname: Ross
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006501:Hepatic Encephalopathy / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007294:Inositol