A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII.
A 1.2-kb cDNA clone isolated from a HeLa cell library contains an open reading frame encoding a new protein (p21) of 21 kDa that is approx. 48% similar to members of the eukaryotic transcription elongation factor SII (TFIIS) family. The deduced amino-acid sequence of p21 indicates that it is hydrophilic, basic and contains nuclear localization signals, as well as multiple consensus phosphorylation sites.
Yeh
C H
CH
Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854.
Shatkin
A J
AJ
D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; C087628:TCEAL1 protein, human; D014157:Transcription Factors; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors; C018648:transcription factor S-II