Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia.
OBJECTIVE
The primary infection with human herpesvirus-6 developed concurrently with diagnosis of acute lymphoblastic leukemia and initiation of intensive chemotherapy for the disease in a 4-month-old girl.


RESULTS
Prolonged viremia persisted for 7 days in the presence of neutralizing antibodies, and clinical features such as prolonged febrile and diarrheal period, no appearance of skin rash, and marked bulging fontanelle for 7 days in the absence of the virus DNA in spinal fluid may suggest an atypical clinical course of exanthem subitum and an unusual viral replication in immunocompromised condition.
Yoshikawa
T
T
Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.
Kobayashi
I
I
Asano
Y
Y
Nakashima
T
T
Yazaki
T
T
Kojima
S
S
Yamada
A
A
D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D014766:Viremia / Q000150:complications*
D004279:DNA, Viral