Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics.
In this study, we investigated the relation between calcium kinetic indices of bone remodeling (resorption rate, r; and formation rate, m, respectively) and two serum markers of type I collagen turnover: the pyridinoline cross-linked carboxyterminal telopeptide domains of type I collagen (S-ICTP a marker of bone matrix degradation) and the carboxyterminal propeptide of human type I procollagen (S-PICP, a marker of bone matrix formation). We studied three groups: (i) healthy controls (n = 19), (ii) a mixed group of high and low-turnover bone diseases without mineralization defects (myxedema, thyrotoxicosis and primary hyperparathyroidism n = 38), and (iii) osteoporosis (n = 52). In healthy controls, a significant regression of S-PICP on m was obtained (R = 0.53, SEE/Y = 0.44, P < 0.02). Significant regressions were also demonstrable in high- and low-turnover bone disease (R = 0.50, P < 0.001), SEE/Y = 61%) and osteoporosis (R = 0.49, P < 0.001, SEE/Y = 50%). In controls the regression coefficient for the regression of S-ICTP on r was 0.19 (NS), in high and low turnover bone disease 0.66, (SEE/Y = 59%, P < 0.001) and in the osteoporotic group 0.40 (SEE/Y = 61%, P < 0.01). We conclude that S-PICP and S-ICTP reflect whole skeletal bone formation and resorption rates in a variety of metabolic bone diseases including osteoporosis.
Charles
P
P
University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark.
Mosekilde
L
L
Risteli
L
L
Risteli
J
J
Eriksen
E F
EF
D000293:Adolescent; D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000097:blood*; D016723:Bone Remodeling; D002118:Calcium / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D024042:Collagen Type I; D017364:Collagenases / Q000378:metabolism; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000097:blood; D010024:Osteoporosis / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011347:Procollagen / Q000097:blood; D012016:Reference Values; D012044:Regression Analysis; D013971:Thyrotoxicosis / Q000097:blood; D014357:Trypsin / Q000378:metabolism
D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen; D014357:Trypsin; D017364:Collagenases; D002118:Calcium