The bone marrow in murine AIDS.
In order to increase the understanding of blood cytopenias in HIV infection we have investigated the bone marrow in murine AIDS. C57BL/6 mice infected with the LP-BM5 retrovirus show a decrease in cellularity, numerous haemophagocytic histiocytes, a reduction of all erythroid precursor cells, an increase in eosinophil number and an increase in lymphocytes. Immunostaining with an anti-Pr60gag antibody shows that the majority of bone marrow cells express the viral protein. Thus, the bone marrow in MAIDS has many similarities with the bone marrow from patients with advanced AIDS and may prove useful as a model for therapy aimed at treating blood cytopenias.
Magnani
M
M
Istituto di Chimica Biologica G. Fornaini, Università degli Studi di Urbino, Italy.
Brandi
G
G
Rossi
L
L
Carnevali
A
A
Fraternale
A
A
Albano
A
A
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002452:Cell Count; D015683:Gene Products, gag / Q000032:analysis; D009052:Leukemia Virus, Murine; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000473:pathology*
D015683:Gene Products, gag