title: Platelet serotonin uptake in duodenal ulcer patients.
abstract: Platelet serotonin uptake was measured in 10 duodenal ulcer patients and 10 controls by determining the concentration of radioactivity in platelets after incubation with tritium-labelled serotonin binoxalate. Platelet 5-HT uptake in ulcer patients (312.0 +/- 125.0 CPM/10(7) platelets) was significantly higher than that in the control group (186.0 +/- 53.0 CPM/10(7) platelets; p < 0.01). Since the kinetics of 5-HT uptake by platelets may be a reflector of enhanced serotonergic activity, this finding may have implications in future therapeutic strategies for this disease.
authors.affiliation: Department of Medicine, King George's Medical College, Lucknow.
authors.forename: R
authors.initials: R
authors.lastname: Misra
authors.forename: R
authors.initials: R
authors.lastname: Komandur
authors.forename: M
authors.initials: M
authors.lastname: Chandra
authors.forename: K
authors.initials: K
authors.lastname: Shankar
authors.forename: S M
authors.initials: SM
authors.lastname: Zaheer
authors.forename: S
authors.initials: S
authors.lastname: Ram
authors.forename: V R
authors.initials: VR
authors.lastname: Gujrati
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin