title: [Free appendix mucosa urethroplasty. A preliminary experimental study of free grafts of digestive tract mucosa].
abstract: The various tissues used as free grafts in urethroplasties are associated with a high incidence of fistulae and strictures. The search for a new, more effective substitute has led the authors to study the possibility of using a new type of mucosa: appendicular mucosa. The size and cylindrical structure of the appendix and its easy resection make it an original and adapted urethral substitute. As most animals do not possess an appendix, an animal model of subcutaneous free graft of colonic mucosa was studied. Segmental transverse colonectomy was performed in 16 rats. The mucosa was stripped and then grafted subcutaneously. Three to six weeks after the operation, this mucosa was still perfectly viable in 11 rats. Its fixation ensures a better take of the graft. Histological examination revealed that the epithelium retained the features of gastrointestinal mucosa: monostratified, pavement and secretory. The results of this preliminary study are very encouraging and justify continuation of experimental studies of free appendicular mucosal urethroplasties. A practical application is expected in the correction of severe hypospadias or extensive urethral strictures.
authors.affiliation: Clinique chirurgicale infantile, CHU Charles Nicolle, Rouen.
authors.forename: T
authors.initials: T
authors.lastname: Lebret
authors.forename: F
authors.initials: F
authors.lastname: Gobet
authors.forename: M
authors.initials: M
authors.lastname: Dallaserra
authors.forename: P
authors.initials: P
authors.lastname: Mitrofanoff
mesh_terms: D000818:Animals; D001065:Appendix; D003106:Colon; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005260:Female; D006085:Graft Survival; D007249:Inflammation; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D007962:Leukocytes / Q000473:pathology; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014521:Urethra / Q000601:surgery*
vernacular_title: Urétroplastie en muqueuse appendiculaire libre. Etude expérimentale préliminaire sur les greffons libres de muqueuse digestive.