Local interleukin-2 therapy for cancer, and its effector induction mechanisms.
This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions and the peritoneal cavity induce LAK cells and secondary production of other cytokines responsible for up- or down-regulation of LAK activity. An understanding of the regulatory mechanism of local LAK induction in vivo may provide the rationale for a more effective therapeutic modality for cancer in humans.
Sone
S
S
Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan.
Ogura
T
T
D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D009369:Neoplasms / Q000628:therapy*; D016896:Treatment Outcome
D016207:Cytokines; D007376:Interleukin-2