Transmission-blocking immunity against malaria and other vector-borne diseases.
Antibodies to sexual stage malaria parasites block transmission of Plasmodium by female mosquitoes. With the recent isolation of genes encoding several of the target antigens of transmission-blocking antibodies, the development of a subunit transmission-blocking vaccine against malaria is now a realistic goal.
Kaslow
D C
DC
Laboratory of Malaria Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
D000595:Amino Acid Sequence; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D007109:Immunity; D017780:Malaria Vaccines / Q000276:immunology*; D016778:Malaria, Falciparum / Q000517:prevention & control* / Q000635:transmission; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology; D015800:Protozoan Proteins / Q000737:chemistry / Q000276:immunology
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D017780:Malaria Vaccines; D015800:Protozoan Proteins