title: [Comparison of the effects of molsidomine retard and isosorbide dinitrate retard in patients with stable angina pectoris using an ergometry test].
abstract: In 24 men with angina after exertion the authors assessed, using ergometry, the action of molsidomine retard and isosorbide dinitrate retard after a single dose and after tree-week administration of the drug. The authors found that 8 mg of molsidomine retard in a single dose had a somewhat more potent effect than 40 mg isosorbide dinitrate retard. After prolonged administration the effect of both drugs on haemodynamics diminished and in molsidomine a significant decline of action was observed before development of a reduced S-T segment on the ECG. After three weeks' administration the effects of both drugs were comparable. After neither drug clinically significant tolerance developed when the drug was administered every 8 hours. In the conclusion the authors discuss possible mechanisms involved in development of tolerance.
authors.affiliation: I. klinika vnitrních chorob FNsP, Brno-Bohunice.
authors.forename: P
authors.initials: P
authors.lastname: Rotrekl
authors.forename: J
authors.initials: J
authors.lastname: Vlasínová
authors.forename: J
authors.initials: J
authors.lastname: Manousek
authors.forename: B
authors.initials: B
authors.lastname: Semrád
authors.forename: F
authors.initials: F
authors.lastname: Rysavý
authors.forename: Z
authors.initials: Z
authors.lastname: Lupínek
authors.forename: J
authors.initials: J
authors.lastname: Meluzín
authors.forename: I
authors.initials: I
authors.lastname: Vlasicová
authors.forename: I
authors.initials: I
authors.lastname: Pirochtová
authors.forename: O
authors.initials: O
authors.lastname: Bocek
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D003692:Delayed-Action Preparations; D008981:Molsidomine; D007548:Isosorbide Dinitrate
vernacular_title: Srovnání úcinků retardovaného molsidominu a retardovaného isosorbiddinitrátu u nemocných se stabilní anginou pectoris pomocí ergometrického vysetrení.