title: Automated single-voxel proton MRS: technical development and multisite verification.
abstract: To improve clinical utility, an integrated method has been developed to automatically acquire and process single-voxel in vivo proton spectra on a 1.5 T clinical scanner. This method includes automated adjustment of linear shims using a very rapid modified simplex method, automated water suppression, and applies a water referencing scheme to correct for phase and residual eddy current effects. No operator intervention is required for the acquisition and processing of these pure-absorption spectra. This method was tested in a preliminary multisite trial to determine intersite and intrasite variability of metabolite ratio measurements. In a sample of over 100 examinations, the standard deviation of the ratios NAA:Cr, Cho:Cr, and ml:Cr were found to be under 15% when using this method, a substantially narrower range than has been found in studies relying on manual adjustment of the instrument and/or manual processing. This result indicates that automated setting of acquisition and processing parameters is of critical importance in the clinical application of in vivo spectroscopy.
authors.affiliation: GE Medical Systems, Fremont, CA 94539.
authors.forename: P G
authors.initials: PG
authors.lastname: Webb
authors.forename: N
authors.initials: N
authors.lastname: Sailasuta
authors.forename: S J
authors.initials: SJ
authors.lastname: Kohler
authors.forename: T
authors.initials: T
authors.lastname: Raidy
authors.forename: R A
authors.initials: RA
authors.lastname: Moats
authors.forename: R E
authors.initials: RE
authors.lastname: Hurd
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*