Corticotropin-dependent Cushing's syndrome in a patient with chronic renal failure--a rare association.
Corticotropin-dependent Cushing's syndrome was detected in a 32-year-old male suffering from membranous nephropathy and chronic renal failure. Cortisol dynamics revealed high basal cortisol, loss of circadian rhythm, and nonsuppressibility with low-dose dexamethasone. However, the latter was suppressible with high-dose dexamethasone. Treatment with ketoconazole led to a remarkable response both clinically and biochemically. The occurrence of Cushing's syndrome in a patient with chronic renal failure is extremely rare and poses significant diagnostic and therapeutic problems.
Jain
S
S
Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sakhuja
V
V
Bhansali
A
A
Gupta
K L
KL
Dash
R J
RJ
Chugh
K S
KS
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003907:Dexamethasone; D015433:Glomerulonephritis, Membranous / Q000150:complications; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007654:Ketoconazole / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male
D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D007654:Ketoconazole; D006854:Hydrocortisone