title: A critical review of the optimum duration of chronic rodent testing for the determination of non-tumourigenic toxic potential: a report by the BTS Working Party on Duration of Toxicity Testing.
abstract: This review indicates that for the detection of non-neoplastic toxic effects: 1. Four decades of accumulated literature provide no lead as to the optimum duration of repeat dose toxicity testing required for all classes of chemicals, although 6 months repeated administration appears adequate for pharmaceuticals. 2. Three month studies predicted the 2 year outcome for 70% of the compounds evaluated in this pilot study using data published by the US National Toxicology Program. 3. In spite of the limitations of this pilot study, this finding is considered encouraging as it is close to that generated previously on more detailed confidential pharmaceutical data. This suggests that the exercise should now be expanded using confidential surveys of industrial data to determine the concordance resulting from the evaluation of a larger group of chemicals.
authors.affiliation: Zeneca Pharmaceuticals, Alderley Park, Macclesfield, UK.
authors.forename: G
authors.initials: G
authors.lastname: Betton
authors.forename: A
authors.initials: A
authors.lastname: Cockburn
authors.forename: E
authors.initials: E
authors.lastname: Harpur
authors.forename: J
authors.initials: J
authors.lastname: Hopkins
authors.forename: P
authors.initials: P
authors.lastname: Illing
authors.forename: C
authors.initials: C
authors.lastname: Lumley
authors.forename: T
authors.initials: T
authors.lastname: Connors
mesh_terms: D000818:Animals; D015386:Hazardous Substances / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D051381:Rats; D013997:Time Factors; D014116:Toxicology / Q000379:methods / Q000592:standards*
chemical_list: D015386:Hazardous Substances