Free radical bombing of spermatozoa in spermatic granuloma: an attempt to prevent autoimmune switch-on.
Even though vasectomy-associated reactions in subjects are established, the biochemical attributes of the granuloma cells enabling them to potently dispose of the accumulating spermatozoa remain unelucidated. This study demonstrates a careful "free-radical bombing" within the granuloma interior to efficiently disintegrate all the structural elements of the sperm cells, especially the proteins. A free radical triggered and instantaneous protein-disposal could be important in avoiding early post-vasectomy autoimmune triggering.
Chatterjee
S
S
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, M.P., India.
Laloraya
M
M
Kumar
G P
GP
D000818:Animals; D005609:Free Radicals; D006099:Granuloma / Q000503:physiopathology*; D008297:Male; D008560:Membrane Fluidity; D051381:Rats; D017208:Rats, Wistar; D013094:Spermatozoa; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry; D014659:Vasectomy
D005609:Free Radicals; D013481:Superoxides; D013482:Superoxide Dismutase