[The peroxidation of pulmonary surfactant lipids in the postradiation period].
In experiments with Wistar female rats it has been shown that an acute whole-body gamma irradiation with doses of 2 and 7 Gy initiates lipid peroxidation in pulmonary surfactant (Sf). Increase in the level of lipid peroxidation products in Sf (hydroperoxides and TBA-active products) was observed during 2 months. Decrease in enzymatic activity of superoxide dismutase and glutathione reductase was occurred in the first hours reaching the minimum on days 7-14 after irradiation period. In animals exposed to dose of 0.5 Gy the normalization of the indices under study was observed on 30th day. The findings demonstrate a destructive effect of lipid peroxidation on pulmonary Sf at the average and lethal exposure doses.
Palagina
M V
MV
Gel'tser
B I
BI
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D015227:Lipid Peroxidation / Q000528:radiation effects*; D011663:Pulmonary Surfactants / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014916:Whole-Body Irradiation
D011663:Pulmonary Surfactants
Perekisnoe okislenie lipidov surfaktanta legkogo v postradiatsionnom periode.