Fatal overdose of 2,4-dichlorophenoxyacetic acid (2,4-D).
An ingestion of an unknown quantity of U 46 D-Fluid (500 g dichlorophenoxyacetic acid/l) in a suicide is described. Although 2,4-dichlorophenoxyacetic acid (2,4 D) is widely used as a herbicide, intoxications are relatively rare. Quantitation of 2,4-D was performed by diethyl ether extraction from acidified samples (viscera) or by deproteinization (blood, plasma) with methanol before HPLC analysis. Postmortem concentrations of 2,4-D in body fluids and tissues are given. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with phenoxyacetic herbicides.
Keller
T
T
Institute for Forensic Medicine, University of Heidelberg, Germany.
Skopp
G
G
Wu
M
M
Aderjan
R
R
D015084:2,4-Dichlorophenoxyacetic Acid / Q000032:analysis / Q000506:poisoning*; D001826:Body Fluids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced; D011180:Postmortem Changes; D012680:Sensitivity and Specificity; D013405:Suicide
D015084:2,4-Dichlorophenoxyacetic Acid