Parvovirus B19-associated haemophagocytic syndrome with prominent neutrophilia.
We describe a patient with both haemophagocytic syndrome and acute myocarditis probably associated with parvovirus B19 infection. The patient had a marked neutrophilia instead of neutropenia more usually observed in virus-associated haemophagocytic syndrome (VAHS). Endogenous serum concentrations of macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), and tumour necrosis factor-alpha (TNF-alpha) were higher than normal, suggesting that these cytokines may be involved in the genesis of the observed syndrome.
Tsuda
H
H
Division of Clinical Haematology/Immunology, Kumamoto City Hospital, Japan.
Maeda
Y
Y
Nakagawa
K
K
Nakayama
M
M
Nishimura
H
H
Ishihara
A
A
Miyayama
H
H
D000208:Acute Disease; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007964:Leukocytosis / Q000382:microbiology*; D009205:Myocarditis / Q000382:microbiology*; D009504:Neutrophils / Q000473:pathology*