title: [Drug resistance in endogenous depression Part II. Refractoriness to antidepressants in affective disorders].
abstract: Among 67 patients admitted for the first time to the hospital drug resistance was evaluated in the further course of disease for at least 3 consecutive depressive phases. It was established that drug resistance occurs (usually as a single episode) in 28% of patients with endogenous depression and it concerns 10% of all depressive phases. The drug resistance is more frequent after the 45th year of life. The incidence of therapeutic failures is 3% during the first depressive phase and goes up in the consecutive phases. The occurrence of drug resistance in the past has no prognostic value for the next phase. There is a certain subgroup of patients, characterized by repetitive drug resistance during several phases. This phenomenon needs further evaluation.
authors.affiliation: II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii w Warszawie.
authors.forename: S
authors.initials: S
authors.lastname: Puzyński
authors.forename: I
authors.initials: I
authors.lastname: Koszewska
authors.forename: A
authors.initials: A
authors.lastname: Kalinowski
authors.forename: E
authors.initials: E
authors.lastname: Bogdanowicz
authors.forename: L
authors.initials: L
authors.lastname: Swiecicki
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013315:Stress, Psychological; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents
vernacular_title: Lekooporność w depresjach endogennych Cześć II. Wystepowanie lekooporności w kolejnych nawrotach depresji.