[The influence of diamide on the realization of the radioprotective effect of beta-mercaptoethylamine in the postradiation period].
In the experiments with Ehrlich ascites tumor cells it was shown that specific oxidation of cellular glutathione after irradiation produced no effect on the degree of radiation injury in the air, but resulted in a decrease of radioprotective effect of beta-mercaptoethylamine. From these results it follows that for a complete realization of radioprotective effect normal level of cellular glutathione is necessary.
Konstantinova
M M
MM
Panaeva
S V
SV
Dontsova
G V
GV
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism; D003543:Cysteamine / Q000494:pharmacology* / Q000627:therapeutic use; D003958:Diamide / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects
D003958:Diamide; D003543:Cysteamine; D005978:Glutathione
Vliianie diamida na realizatsiiu radiozashchitnogo éffekta beta-merkaptoétilamina v postradiatsionnom periode.