[Results of combination therapy of inflammatory carcinoma of the breast].
Mastitis carcinomatosa or inflammatory breast cancer (IBC) is a very rare form of breast cancer with aggressive progression, as well as rapid dissemination. Though this disease has been for a long time in focus of interest of clinicians, the problem of its treatment is still unsolved. In the Belgrade Institute of Oncology and Radiology IBC has been already treated with combination of chemotherapy and radiotherapy, and results of such treatment are evaluated and presented in this paper. Taking into account results of the above mentioned treatment as well as that reported in literature, we decided to make its modification. Irradiation was carried out by hyperfractionation, preceded and followed by chemotherapy. Hyper-fractionated regime was assessed using LQ model for determination of radiobiological efficiency. The obtained results showed only a percentual, but not statistically significant improvement. The presented treatment was only an attempt after which it could be concluded that the oncologist today, no matter whatsoever he was trying in the treatment of IBC, could not expect extraordinary results, but must be satisfied with the fact that he has given his best help. Nevertheless, we find our attempt valuable since it gives new opportunities for non-conventional radiotherapeutic treatment, as well as new perspectives in the treatment of IBC, but always in combination with systemic therapy.
Borojević
N
N
Institut za onkologiju i radiologiju, Beograd.
Zamurović
J
J
D000230:Adenocarcinoma / Q000628:therapy*; D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged
Rezultati kombinovanog nacina lecenja inflamacionog karcinoma dojke.