[The premedication of PTA. A double-blind and randomized comparison of midazolam/tramadol versus placebo/tramadol].
A prospective, randomised and double blind comparative study of Midazolam/Tramadol or placebo/Tramadol for premedication before PTA was carried out on 40 patients (12 female and 28 male, average age 66.1 +/- 12). The anxiolytic, analgesic and general findings were quantified by means of a visual analogue score. Pre- and peri-interventional blood gas, blood pressure and pulse rates were determined. The complications of the two schemes were compared. 19 patients received Midazolam/Tramadol and 21 placebo/Tramadol. Patient anxiety was reduced significantly from 25.8 +/- 25 to 4.3 +/- 6 by premedication. Significant increase in the pain score during PTA was observed only in the placebo group (4.3 +/- 12.6 to 27.4 +/- 20.9). There was no difference in the incidence of complications and respiratory depression due to the Midazolam/Tramadol combination was not observed.
Alfke
H
H
Abteilung für Strahlendiagnostik, Philipps-Universität Marburg.
Reuter
P
P
Wagner
H J
HJ
Böhme
K
K
D000368:Aged; D000800:Angioplasty, Balloon / Q000706:statistics & numerical data; D001784:Blood Gas Analysis; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011292:Premedication / Q000706:statistics & numerical data; D015641:Radiography, Interventional; D014147:Tramadol / Q000009:adverse effects / Q000627:therapeutic use*
D010919:Placebos; D014147:Tramadol; D008874:Midazolam
Prämedikation der PTA. Doppelblinder und randomisierter Vergleich von Midazolam/Tramadol versus Placebo/Tramadol.