Radiorecovery activity of manganese(III)2(II)(mu 3-O)-(mu-3,5-diisopropylsalicylate)6.
Manganese(III)2(II)(mu 3-O)(mu-3,5-diisopropylsalicylate)6 [Mn3(O)(3,5-DIPS)6] was used to treat female C57BL/6 mice irradiated with LD50/30 doses of gamma rays and examine the possibility that treatment after irradiation increases survival. Female C57BL/6 mice were treated with 0, 10, 20, or 40 mumol Mn3(O)(3,5-DIPS)6/kg of body mass 1 or 3 h after irradiation. Treatment with 40 mumol/kg 1 or 3 h after irradiation produced survivals of 72 or 92%, respectively, increases of 29 or 130% in comparison with 56 or 40% survivals in the respective vehicle-treated groups. These data support the hypothesis that Mn3(O)(3,5-DIPS)6 is an effective radiorecovery agent.
Henderson
T D
TD
Department of Chemistry, University of Arkansas at Pine Bluff 71601.
Burt
R L
RL
Kaufman
S E
SE
Willingham
W M
WM
Sorenson
J R
JR
D000818:Animals; D005260:Female; D005720:Gamma Rays; D017895:Manganese Compounds / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009942:Organometallic Compounds / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012459:Salicylates / Q000494:pharmacology*
D017895:Manganese Compounds; D009942:Organometallic Compounds; D011837:Radiation-Protective Agents; D012459:Salicylates; C083822:manganese(III)(2)(II)(mu3-oxo)-hexakis(mu-3,5-diisopropylsalicylate)