title: cMpl ligand is a humoral regulator of megakaryocytopoiesis.
abstract: Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors, and the second, thrombopoietin, is a megakaryocyte maturation factor. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family, is specifically involved in megakaryocyte regulation. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule.
authors.affiliation: INSERM U362, Institut Gustave Roussy, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Wendling
authors.forename: E
authors.initials: E
authors.lastname: Maraskovsky
authors.forename: N
authors.initials: N
authors.lastname: Debili
authors.forename: C
authors.initials: C
authors.lastname: Florindo
authors.forename: M
authors.initials: M
authors.lastname: Teepe
authors.forename: M
authors.initials: M
authors.lastname: Titeux
authors.forename: N
authors.initials: N
authors.lastname: Methia
authors.forename: J
authors.initials: J
authors.lastname: Breton-Gorius
authors.forename: D
authors.initials: D
authors.lastname: Cosman
authors.forename: W
authors.initials: W
authors.lastname: Vainchenker
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology; D002454:Cell Differentiation; D002460:Cell Line; D004285:Dogs; D058851:GPI-Linked Proteins; D006706:Homeostasis; D006801:Humans; D007106:Immune Sera; D008024:Ligands; D008533:Megakaryocytes / Q000166:cytology*; D008562:Membrane Glycoproteins; D000090204:Mesothelin; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000502:physiology; D000090063:Proto-Oncogene Mas; D051381:Rats; D017208:Rats, Wistar; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction; D013552:Swine; D013926:Thrombopoietin / Q000378:metabolism*; D014916:Whole-Body Irradiation
chemical_list: D058851:GPI-Linked Proteins; D007106:Immune Sera; D008024:Ligands; C000715470:MAS1 protein, human; D008562:Membrane Glycoproteins; D011506:Proteins; D000090063:Proto-Oncogene Mas; D011971:Receptors, Immunologic; D013926:Thrombopoietin; D000090204:Mesothelin