[Brain morphometry using MRI in Cri-du-Chat Syndrome. Report of seven cases with review of the literature].
The authors present the results of a morphometric study of the brain of 7 patients with cat cry syndrome, explored with Magnetic Resonance Imaging (MRI). A method is proposed in order to facilitate the identification of the anatomical slices. A characteristic anomaly is observed as a marked atrophy of the brainstem predominating at the pontine level and associated with a small cerebellum, atrophic middle cerebellar peduncles and cerebellar white matter. This apparently systematized atrophy obvious in children, seems similar to the one observed in patients presenting a olivopontocerebellar atrophy, possibly correlating with disturbance of coordination and developmental delay in motility as observed in these patients. This does not implicate the same subjacent functional neuroanatomical pathways.
Tamraz
J
J
Service de Neuroradiologie et d'lRM, Hôtel-Dieu de France, Université Saint-Joseph de Beyrouth, Paris.
Rethoré
M O
MO
Lejeune
J
J
Outin
C
C
Goepel
R
R
Stievenart
J L
JL
Iba-Zizen
M T
MT
Cabanis
E A
EA
D000293:Adolescent; D000328:Adult; D001699:Biometry; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D008297:Male
Morphométrie encéphalique en irm dans la maladie du chat. A propos de sept patients, avec revue de la littérature. Association pour la recherche sur la sclérose en plaques.