[Effect of UFT and CBDCA combined therapy on human laryngeal cancer transplanted into nude mice].
Nude mice transplanted with a human tumor of the larynx were treated by combination therapy with UFT and carboplatin (CBDCA) for a prolonged period (3 months). To compare the combination therapy with UFT or CBDCA treatment alone, the mice were divided into four groups; control group, group orally given UFT (20mg/kg, five times a week for 3 months), group intraperitoneally given ip CBDCA (50mg/kg, every 3 weeks for 3 months), and group given combination therapy with UFT and CBDCA. No antitumor effect was observed in the group received UFT or CBDCA alone, while a significant antitumor effect was noted in the combination therapy group, compared to the control as evidenced by DNA histogram, showing a decrease in atypical cell count. The results of this study suggest that the combination of UFT and CBDCA provides an efficacious chemotherapy for cancers of the head and neck.
Kubota
T
T
Dept. of Otorhinolaryngology, Fujigaoka Hospital, Showa University.
Nishimura
T
T
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D005641:Tegafur / Q000008:administration & dosage; D014183:Transplantation, Heterologous; D014498:Uracil / Q000008:administration & dosage
D005641:Tegafur; D014498:Uracil; D016190:Carboplatin