title: Tetrasomy 21 in megakaryoblastic leukemia.
abstract: A 23-month-old female evaluated for profound anemia proved to have megakaryoblastic leukemia. The diagnosis is based on examination of bone marrow morphology, cytochemical characteristics, and immunophenotype. The chromosome complement of unstimulated blast cells in peripheral blood and bone marrow was 48,XX,+21,+21. Tetrasomy 21 is the sole clonal cytogenetic abnormality in this patient with megakaryoblastic leukemia. The constitutional complement of the patient is normal female, 46,XX.
authors.affiliation: Department of Pathology, University of Massachusetts Medical Center, Worcester.
authors.forename: L
authors.initials: L
authors.lastname: Potocki
authors.forename: P L
authors.initials: PL
authors.lastname: Townes
authors.forename: B A
authors.initials: BA
authors.lastname: Woda
authors.forename: S K
authors.initials: SK
authors.lastname: Rao
authors.forename: J P
authors.initials: JP
authors.lastname: Shearin
authors.forename: M R
authors.initials: MR
authors.lastname: Schwenn
mesh_terms: D000782:Aneuploidy; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*