Transient increase of aminotransferases in RA patients treated with methotrexate.
Sixty-two patients with rheumatoid arthritis (RA) were treated with methotrexate (MTX) for 3 months. Methotrexate was given orally in a single dose of 7.5-15.0 mg/week. At the onset of the treatment increased activity of aminotransferases has been observed. Eighteen patients (29%) displayed higher enzyme activity in the first 3 weeks. Despite the continuous drug administration the activity of aminotransferase became normal at week 12 in all but one patient. In this patient MTX had to be withdrawn.
Lacki
J K
JK
Department of Immunology and Rheumatology, Karol Marcinkowski University, School of Medicine, Poznan, Poland.
Samborski
W
W
Machiewicz
S H
SH
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology; D001219:Aspartate Aminotransferases / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000201:enzymology; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D016059:Range of Motion, Articular / Q000187:drug effects
D004008:Diclofenac; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008727:Methotrexate