title: Recurring ventriculitis due to Citrobacter diversus: clinical and bacteriologic analysis.
abstract: Neonatal meningitis due to Citrobacter diversus is usually accompanied by the development of brain abscesses and tends to have high rates of morbidity and mortality. We report a case of a newborn with C. diversus meningitis and brain abscesses who relapsed after initial antibiotic therapy and from whom C. diversus was recovered from cerebrospinal fluid 4 years later during a neurosurgical procedure. Genetic differences in the early and late isolates were discovered, and explanations for this phenomenon are suggested. Possible mechanisms for prolonged persistence in the central nervous system are explored. This unusual case and the analysis of the organisms illustrate the unique features of C. diversus as a pathogen and underscore the need for developing optimal therapeutic strategies.
authors.affiliation: Department of Pediatrics, Alfred I. duPont Institute, Wilmington, Delaware 19899.
authors.forename: S C
authors.initials: SC
authors.lastname: Eppes
authors.forename: C R
authors.initials: CR
authors.lastname: Woods
authors.forename: A S
authors.initials: AS
authors.lastname: Mayer
authors.forename: J D
authors.initials: JD
authors.lastname: Klein
mesh_terms: D002555:Cerebrospinal Fluid / Q000382:microbiology; D002675:Child, Preschool; D002954:Citrobacter / Q000254:growth & development / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000382:microbiology*; D012008:Recurrence