A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo.
Chromosome 16 aberrations are well known in acute nonlymphocytic leukemia (ANLL). The most frequent chromosome 16 aberration in ANLL subtype M4Eo is the inv(16)(p13q22). Recently, we showed that in 5 inv(16) patients with ANLL M4Eo the short arm breakpoints are clustered within a 14-kb genomic EcoRI fragment. We report here the identification of a gene situated in the 14-kb fragment. The gene, which codes for a myosin peptide, is disrupted by the inversion of chromosome 16 in the 5 patients. To the best of our knowledge, this is the first report of a myosin gene disrupted in leukemia.
van der Reijden
B A
BA
Department of Human Genetics, Leiden University, The Netherlands.
Dauwerse
J G
JG
Wessels
J W
JW
Beverstock
G C
GC
Hagemeijer
A
A
van Ommen
G J
GJ
Breuning
M H
MH
D001483:Base Sequence; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000737:chemistry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D009218:Myosins / Q000235:genetics*
D018076:DNA, Complementary; D009218:Myosins