Effect of clinical death on inositol 1,4,5-trisphosphate in the rat brain.
Changes of inositol 1,4,5-trisphosphate content in the rat brain have been evaluated by means of the radioimmunologic method during 5-min clinical death and up to 2 hrs after resuscitation. Ischemia produced a decrease of IP3 content in the brain on the average to 63% of the control values. IP3 concentration in the brain increased on the average to 197% of the control values at the 15th min after resuscitation, and decreased to 127% at the 60 min. Two hours after resuscitation the IP3 content in the brain again increased on the average to 187%. The new data on brain metabolism in the ischemic conditions and the role of IP3 as the second messenger and mediator of neuromodulation processes are discussed.
Kapuściński
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Department of Neuropathology, Polish Academy of Sciences, Warsaw.
D000818:Animals; D015415:Biomarkers; D001923:Brain Chemistry; D001926:Brain Death / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006868:Hydrolysis; D015544:Inositol 1,4,5-Trisphosphate / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D012151:Resuscitation; D015290:Second Messenger Systems; D013997:Time Factors
D015415:Biomarkers; D015544:Inositol 1,4,5-Trisphosphate