title: Cerebral germ cell tumor and XXY karyotype.
abstract: Metaphases from a cultured cerebral germ cell tumor (CGCT) in a boy with a 46,XY constitutional karyotype had 47 chromosomes with an additional X chromosome and a translocation (1;21)(q11;p11). CGCT appear to be nonrandomly associated with Klinefelter syndrome, and a supernumerary X chromosome and trisomy of the 1q21-->1qter region may be clonal abnormalities in these tumors. The predisposition of Klinefelter patients to develop CGCT may be due to the pathogenetic relevance of the extra X chromosome both as an acquired and a constitutional abnormality.
authors.affiliation: Biologia Generale e Genetica Medica, Università di Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Casalone
authors.forename: R
authors.initials: R
authors.lastname: Righi
authors.forename: P
authors.initials: P
authors.lastname: Granata
authors.forename: P
authors.initials: P
authors.lastname: Portentoso
authors.forename: E
authors.initials: E
authors.lastname: Minelli
authors.lastname: Meroni
authors.forename: C L
authors.initials: CL
authors.lastname: Solero
authors.forename: A
authors.initials: A
authors.lastname: Allegranza
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D006801:Humans; D066298:In Vitro Techniques; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics; D008297:Male; D013724:Teratoma / Q000235:genetics*; D014407:Tumor Cells, Cultured; D014960:X Chromosome