Cardiac paraprotein associated with Waldenstrom's macroglobulinemia: a case report.
A case of myocardial paraprotein deposition in a patient with Waldenstrom's macroglobulinemia is presented. Routine light microscopy revealed diffuse widening of interstitial regions by pale eosinophilic material that had a grayish cast on trichrome stains and was Congo red negative. Immunofluorescence showed strong immunoglobulin M and kappa light chain staining around blood vessels but predominantly around myocytes. Ultrastructural examination revealed massive deposition of flocculent electron-dense material around myocytes and occasionally around blood vessels.
Yowell
R L
RL
LDS Hospital Electron Microscopy Laboratory, Salt Lake City, Utah.
Hammond
E H
EH
D000328:Adult; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism*; D010266:Paraproteins / Q000378:metabolism*; D008258:Waldenstrom Macroglobulinemia / Q000378:metabolism*
D010266:Paraproteins