[Range of neuromuscular involvement in 47 patients infected with the human immunodeficiency virus].
Over a 30 month period, 47 out of 749 patients infected with the human immunodeficiency virus had various neuromuscular symptoms. Based on clinical and electrophysiological data, 47% had distal symmetric polyneuropathy, 11% chronic inflammatory demyelinating polyneuropathy (CIDP), 8.5% toxic neuropathy related to 2-3-dideoxyinosine (DDI), 8.5% cranial neuropathy, 8.5% mononeuropathy multiplex or isolated focal neuropathy, 8.5% progressive lumbosacral polyradiculopathy, and 8.5% myopathy. Half of the patients exhibited previous or concomitant signs of central nervous system involvement and 18 patients died during the study period. CIDP and cranial neuropathies usually appeared early in the course of the disease and consequently showed neurological improvement. Nerve conduction studies of DDI related toxic neuropathies showed distal axono-myelinic sensitivo-motor neuropathy, differing from CIDP by the absence of a conduction block. Distal symmetric polyneuropathies, frequent in the advanced systemic illness, do not systematically require an extended workup, but more unusual peripheral neuropathies which might be treatable necessitate further investigations (electromyography, radiology, serological blood tests; protein chemistry and routine workup of the cerebrospinal fluid). For example, progressive lumbosacral polyradiculopathies responded to early treatment, with a better outcome in one case of herpetic origin than in another case due to cytomegalovirus infection. Our observations suggest that myopathies in HIV infected patients should first be tackled by temporary interruption of virostatic medication, followed by muscle biopsy if the symptoms persist.
Ghika-Schmid
F
F
Service de neurologie, Centre hospitalier universitaire vaudois, Lausanne.
Kuntzer
T
T
Chave
J P
JP
Miklossy
J
J
Regli
F
F
D015526:AIDS Dementia Complex / Q000150:complications*; D000328:Adult; D000368:Aged; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000150:complications; D003389:Cranial Nerve Diseases / Q000150:complications; D016049:Didanosine / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009468:Neuromuscular Diseases / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000150:complications
D016049:Didanosine
Diversité de l'atteinte neuromusculaire de 47 patients infectés par le virus de l'immunodéficience humaine.