Immunodeficiency-inducing retroviruses.
The plethora of disease syndromes (dystrophy of various organ systems, malignancies and opportunistic infections) caused by HIV are all potentiated by the profound virus-induced immunosuppression that accompanies this infection. The mechanism of this severe immunosuppression is poorly understood and the subject is currently being pursued in studies of HIV-infected patients and in animals infected with other immunodeficiency-inducing retroviruses.
Joag
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SV
Laboratory of Viral Pathogenesis, Marion Merrell Dow Foundation, Kansas University Medical Center, Kansas City 66160-7424.
Narayan
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O
D000818:Animals; D004195:Disease Models, Animal; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000382:microbiology; D016086:Lentivirus / Q000276:immunology; D012190:Retroviridae / Q000276:immunology; D012192:Retroviridae Infections / Q000276:immunology*