[Azithromycin-omeprazole. Treatment for the eradication of Helicobacter pylori].
OBJECTIVE
To evaluate the benefit of 4-week regimen including azithromycin+omeprazole (vs omeprazole alone) for eradication of Helicobacter pylori.


METHODS
Twenty HP positive patients with an ulcer dyspepsia (NUD) were included in this study. They were given either omeprazole 40 mg for 4 weeks alone or in combination with azithromycin 1 g/die for 1 week. Endoscopy was performed before 4 weeks after and 4 months after treatment. The presence of HP was assessed in antral and corporeal biopsies by urease test and histology.


RESULTS
HP eradication was observed in 9/10 (90%) patients in the omeprazole+azithromycin group and 0/10 patients in the omeprazole alone group.


CONCLUSIONS
Omeprazole 40 mg for 4 weeks in combination with azithromycin 1 g die for 1 week eradicates HP in 90% of these patients. The good eradication percentage and absence of collateral effect make us extend patients' number to test.
Marchi
M
M
Servizio di Endoscopia Digestiva, Ospedale S. Sebastiano, Correggio, Reggio Emilia.
Vacondio
R
R
Bagnulo
A
A
Mengoli
M
M
D000328:Adult; D000368:Aged; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000188:drug therapy; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D017963:Azithromycin; D009853:Omeprazole
Azitromicina-omeprazolo. Trattamento per eradicazione di Helicobacter pylori.