[The action of sodium valproate in central pain syndromes].
A model of acute spinal and phantom pain syndromes caused by the formation of an abnormally increased excitation generator (AIEG) in the system of dorsal horns of the spine was used to study the effects of sodium valproate when used chronically in the phantom pain syndrome, when given in a single dose in the acute pain syndrome and when applied to the spine with disinhibitors inducing the pain syndrome. It was shown that during chronic administration sodium valproate produced a stress-preventive action, but failed to affect pain sensation and to prevent the development of the pain syndrome. When used in the acute pain syndrome, sodium valproate had a marked analgesic effect, and when applied to the spine it substantially reduced the manifestations of the pain syndrome. The action of sodium valproate on the AIEG can be accounted for by the higher GABA level that results in the hyperpolarization of neurons which are a part of AIEG. When the latter is formed and operates in acute and chronic pain syndromes there are differences in the functional activity of the neurochemical structures responsible for the realization of pain reaction components. This is suggested by varying effects of sodium valproate on pain sensation during acute and chronic experiments.
Grafova
V N
VN
Danilova
E I
EI
Reshetniak
V K
VK
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D017288:Pain Threshold / Q000187:drug effects; D010591:Phantom Limb / Q000188:drug therapy / Q000209:etiology; D051381:Rats; D013577:Syndrome; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid
Deĭstvie val'proata natriia pri tsentral'nykh bolevykh sindromakh.