Histamine as an intracellular messenger in human platelets.
The results of investigations in platelets provide evidence for an intracellular messenger role for histamine. Studies of neutrophils and of cellular proliferation suggest that there may be a wider role for histamine as an intracellular messenger modulating activation processes in cells.
Gerrard
J M
JM
Manitoba Institute of Cell Biology, Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
Saxena
S P
SP
McNicol
A
A
D001792:Blood Platelets / Q000502:physiology*; D002455:Cell Division; D004789:Enzyme Activation; D006402:Hematologic Diseases / Q000503:physiopathology; D006632:Histamine / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D015539:Platelet Activation / Q000187:drug effects; D011073:Polyamines / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*
D006633:Histamine Antagonists; D011073:Polyamines; D006632:Histamine; D006640:Histidine Decarboxylase