title: [Probable Bickerstaff's brainstem encephalitis associated with anti-GQ1b antibody].
abstract: We presented a case of probable Bickerstaff's brainstem encephalitis. A 39-year-old woman developed easy falling, progressive consciousness disturbance, total ophthalmoplegia, and bilateral pyramida tract sign. In serum anti-ganglioside antibody assay using enzyme-linked immunosorbent assay, high anti-GQ1b antibody was found. Electroencephalography was dominated by alpha activity, superimposed with occasional theta wave bursts. Brain MRI showed abnormal signal hyperintensities in the tegmentum of the midbrain to the upper pons on T2 weighted images and swelling of the midbrain and pons on T1 weighted images. Five days after the onset of the disease, she had respiratory arrest, which necessitated artificial ventilation for a few days. Then, she began to recover. However, she gained only partial recovery, leaving upward gaze palsy, right abducens nerve palsy, pseudbulbar palsy and quadriplegia.
authors.affiliation: Department of Neurology, Takeda General Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Takano
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
authors.forename: N
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001933:Brain Stem; D004660:Encephalitis / Q000175:diagnosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008279:Magnetic Resonance Imaging
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; C039129:GQ1b ganglioside