title: Additive effect of lithium and clonidine with 5-HT1A agonists in the forced swimming test.
abstract: 1. The aim of the present work was to demonstrate the possible additive effect of lithium and clonidine with 5-HT1a agonists in the forced swimming test. 2. Anti-depressant like effects of 5-HT1a agonists was investigated using forced swimming test. When administered alone, only 8-OH-DPAT reduced the immobility time in mice. 3. 5-HT1a agonists were then tested in combination with clonidine or lithium. Only gepirone and ipsapirone pretreated by either lithium or clonidine reduced immobility time in the forced swimming test. 4. The authors conclude that lithium and clonidine might be useful to predict antidepressant-like activity of new compounds.
authors.affiliation: Department of pharmacology and GIS medicament, Faculty of Medecine, Nantes, France.
authors.forename: M
authors.initials: M
authors.lastname: Hascoet
authors.forename: M
authors.initials: M
authors.lastname: Bourin
authors.forename: S
authors.initials: S
authors.lastname: Khimake
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D008094:Lithium; D003000:Clonidine