title: [Toxic lung damage caused by mitomycin C].
abstract: Lung toxicity is one of the rare side effects of mitomycin C (MMC), an effective antineoplastic agent. There have been only few reports on pulmonary damage after MMC monotherapy. We describe a case of a pulmonary reaction following MMC monotherapy. The patient was examined including bronchoalveolar lavage (BAL) and transbronchial lung biopsy. BAL yielded the diagnosis of a lymphocyte alveolitis with normal CD4/CD8 ratio within the T lymphocytes. Histologically a florid alveolitis was diagnosed. Radiological and CT findings including HR-CT are described.
authors.affiliation: Abteilung für Pneumologie, Johannes Gutenberg-Universität, Mainz.
authors.forename: G
authors.initials: G
authors.lastname: Lenci
authors.forename: J
authors.initials: J
authors.lastname: Müller-Quernheim
authors.forename: J
authors.initials: J
authors.lastname: Lorenz
authors.forename: F
authors.initials: F
authors.lastname: Schweden
authors.forename: R
authors.initials: R
authors.lastname: Ferlinz
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008218:Lymphocytosis / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D016685:Mitomycin
vernacular_title: Toxische Lungenschädigung durch Mitomycin C.