[Corticosteroid treatment regimes and growth hormone secretion in congenital adrenogenital syndrome].
11 patients with 21-hydroxylase deficiency were treated with three different corticosteroids and two different distributions of therapy during daytime. We found that: 1) a higher dose of steroid in the evening had a markedly inhibitory effect on nocturnal GH secretion; 2) of the steroids we used, dexamethasone caused the greatest reduction in nocturnal GH secretion; 3) in this study adrenal hormones seem less influenced by the different distribution of the corticosteroids during the 24 hours period.
Balsamo
A
A
Clinica Pediatrica Ia, Università degli Studi, Policlinico S. Orsola di Bologna, Italia.
Cicognani
A
A
Guacci
P
P
Cassio
A
A
Cacciari
E
E
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D003348:Cortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male
D005938:Glucocorticoids; D003907:Dexamethasone; D013006:Growth Hormone; D003348:Cortisone; D006854:Hydrocortisone
Regimi terapeutici con corticosteroidi e secrezione di ormone della crescita nella sindrome adreno-genitale congenita.