Specificity and promiscuity in membrane helix interactions.
Transmembrane alpha-helices can associate with one another in lipid bilayers. This association is important in the folding and oligomerization of many integral membrane proteins, and may also play a role in their function. The interactions between helices may be highly specific or relatively non-specific, and their roles may differ accordingly. These two cases are discussed.
Lemmon
M A
MA
Department of Pharmacology, New York University Medical Center, NY 10016.
Engelman
D M
DM
D000595:Amino Acid Sequence; D008051:Lipid Bilayers / Q000737:chemistry; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary
D008051:Lipid Bilayers; D046911:Macromolecular Substances; D008565:Membrane Proteins