The association of HLA-B5 antigen with specific manifestations of Behçet's disease.
The HLA-B5 phenotype was investigated in 235 patients with Behçet's disease and in 100 healthy persons. HLA-B5 was more frequent in the patients (77 vs. 30% p < 0.001, relative risk = 7.8). The frequency of HLA-B5 was higher in patients with genital ulceration than without (82.3 vs. 63%, p < 0.01). Patients with thrombophlebitis showed a less frequent positivity of HLA-B5 antigen than the patients without thrombophlebitis (50 vs. 79.2%, p < 0.02). These results suggest that HLA-B5-related genes not only affect the development of Behçet's disease but also the occurrence of its clinical manifestations.
Azizleri
G
G
Department of Dermatology, Istanbul Medical Faculty, Turkey.
Aksungur
V L
VL
Sarica
R
R
Akyol
E
E
Ovül
C
C
D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000276:immunology / Q000473:pathology; D001528:Behcet Syndrome / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D004893:Erythema Nodosum / Q000276:immunology / Q000473:pathology; D005128:Eye Diseases / Q000276:immunology / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000276:immunology / Q000473:pathology; D005831:Genital Diseases, Female / Q000276:immunology / Q000473:pathology; D005832:Genital Diseases, Male / Q000276:immunology / Q000473:pathology; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D013281:Stomatitis, Aphthous / Q000276:immunology / Q000473:pathology; D013924:Thrombophlebitis / Q000276:immunology / Q000473:pathology; D014456:Ulcer / Q000276:immunology / Q000473:pathology
D015235:HLA-B Antigens; C035270:HLA-B5 antigen