title: A fatal case of scleredema of Buschke.
abstract: Scleredema of Buschke is a rare disorder characterized by the development of areas of skin induration which usually resolve spontaneously. It is occasionally associated with a benign gammopathy, and rarely with myelomatosis. We describe a 60-year-old woman with extensive skin changes, who developed IgA myeloma. Unusually, her skin disease did not respond to conventional myeloma therapy. Death occurred as a consequence of the progressive skin disease.
authors.affiliation: Department of Dermatology, Bristol Royal Infirmary, U.K.
authors.forename: J E
authors.initials: JE
authors.lastname: Sansom
authors.forename: A L
authors.initials: AL
authors.lastname: Sheehan
authors.forename: C T
authors.initials: CT
authors.lastname: Kennedy
authors.forename: T J
authors.initials: TJ
authors.lastname: Delaney
mesh_terms: D004947:Esophagus / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007421:Intestine, Small / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000401:mortality; D012592:Scleredema Adultorum / Q000150:complications* / Q000401:mortality / Q000473:pathology
chemical_list: D007070:Immunoglobulin A