title: [Encephalopathy and memory disorders during treatments with mefloquine].
abstract: Benign psychiatric side effects have been frequently associated with mefloquine therapy. On the other hand, severe psychiatric disorders due to mefloquine are rare but must be detected by physicians. Two such cases are reported. In the first case, excessive curative mefloquine therapy caused an acute psychotic state which ultimately regress without treatment. The second report concerns a transient memory failure following prophylactic mefloquine treatment. The causative role of this compound is being discussed and the importance of a differential diagnosis of neuropsychiatric disorders from toxic or parasitic origin is underlined. Circumstances aggravating such neuropsychiatric side effects and actual recommendations concerning the prescription of mefloquine are recalled.
authors.affiliation: Service de réanimation, CMC E-Rain, Gonesse, France.
authors.forename: T
authors.initials: T
authors.lastname: Marsepoil
authors.forename: J
authors.initials: J
authors.lastname: Petithory
authors.forename: J M
authors.initials: JM
authors.lastname: Faucher
authors.forename: P
authors.initials: P
authors.lastname: Ho
authors.forename: E
authors.initials: E
authors.lastname: Viriot
authors.forename: F
authors.initials: F
authors.lastname: Benaiche
mesh_terms: D000328:Adult; D000647:Amnesia / Q000139:chemically induced*; D000962:Antimalarials / Q000009:adverse effects; D006801:Humans; D008297:Male; D015767:Mefloquine / Q000009:adverse effects*; D008875:Middle Aged; D011605:Psychoses, Substance-Induced
chemical_list: D000962:Antimalarials; D015767:Mefloquine
vernacular_title: Encéphalopathie et troubles mnésiques au cours des traitements par la méfloquine.