title: Physiopathological mechanisms of gastro-oesophageal reflux: is motility the clue?
abstract: Most of the physiopathological mechanisms of gastro-oesophageal reflux (GOR) disease are well known since many years. Nevertheless, it is very poorly understood why mechanisms differ from patient to patient. The relative importance of the factors involved is difficult to assess since they actually interfere with each other. The role of delayed gastric emptying related or not to increased abdominal pressure might be underestimated, as is the vicious circle of "GOR inducing GOR".
authors.affiliation: Kinderziekenhuis, AZ-VUB, Brussels.
authors.forename: Y
authors.initials: Y
authors.lastname: Vandenplas
mesh_terms: D000293:Adolescent; D000328:Adult; D001647:Bile Acids and Salts / Q000502:physiology; D002648:Child; D004943:Esophagogastric Junction / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006551:Hernia, Hiatal / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000503:physiopathology; D010434:Pepsin A / Q000378:metabolism; D010528:Peristalsis; D014357:Trypsin / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D014357:Trypsin; D010434:Pepsin A