title: Myelodysplastic syndrome with eosinophilia in bone marrow. Gunma Haematology Study Group.
abstract: Clinical features were investigated in 114 patients with de novo myelodysplastic syndrome (MDS) diagnosed over the past 10 years, and eight cases (7%) were complicated with eosinophilia in the bone marrow. Two patients had refractory anaemia (RA), five had RA with excess of blasts (RAEB), and one had RAEB in transformation. Their bone marrow cells exhibited tri-lineage dysplasia and morphological abnormalities in eosinophils. Cytogenetics revealed major karyotype abnormalities (MAKA) in five patients. Survival durations were significantly shorter than those of other MDS patients. Our study suggests that marrow eosinophilia in MDS is strongly related to the coexistence of MAKA.
authors.affiliation: Third Department of Internal Medicine, Gunma University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Sawamura
authors.forename: J
authors.initials: J
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Sakura
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Hirabayashi
authors.forename: S
authors.initials: S
authors.lastname: Miyawaki
authors.forename: S
authors.initials: S
authors.lastname: Simano
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics / Q000401:mortality