title: Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection.
abstract: Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: J R
authors.initials: JR
authors.lastname: Bautista
authors.forename: G J
authors.initials: GJ
authors.lastname: Schwartz
authors.forename: J C
authors.initials: JC
authors.lastname: De La Torre
authors.forename: T H
authors.initials: TH
authors.lastname: Moran
authors.forename: K M
authors.initials: KM
authors.lastname: Carbone
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight; D001890:Borna Disease / Q000473:pathology* / Q000503:physiopathology*; D001891:Borna disease virus; D005518:Food Preferences; D006728:Hormones / Q000097:blood; D009043:Motor Activity; D009422:Nervous System Diseases / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D011917:Rats, Inbred Lew; D012996:Solutions; D013649:Taste
chemical_list: D006728:Hormones; D012996:Solutions