title: Myoelectric activity during small bowel allograft rejection.
abstract: The effect of rejection on myoelectric activity of an orthotopically transplanted small intestinal segment (group I, N = 14) was studied. Electrodes were placed on grafts and recipient small bowel. Isografts (group II, N = 5) and native bowel (group III, N = 5) served as controls. The first morphological signs of rejection were seen on day 6 and steadily progressed until day 11, when the cellular infiltrate involved all layers of the bowel wall. Slow-wave frequencies remained unchanged throughout the observation period. No difference was detectable between grafts (group I: 31.9 +/- 1.65; group II: 31.36 +/- 0.7) and native bowel after transection (group I: 32.16 +/- 1.78; group II: 31.50 +/- 1.01), which was different (P = 0.0001) from intact bowel of group III animals (38.4 +/- 0.81). Irregular MMCs were detectable in grafts from day 5 on and replaced after food intake by random spiking activities. At day 8, spiking activities disappeared in allografts, which showed a still preserved mucosal architecture, while slow-wave activities continued. These findings demonstrate that intestinal allografts during rejection develop paralysis before mucosal destruction is established, which might be of clinical relevance.
authors.affiliation: Department of Transplant Surgery, University Hospital, Innsbruck, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Pernthaler
authors.forename: A
authors.initials: A
authors.lastname: Kreczy
authors.forename: R
authors.initials: R
authors.lastname: Plattner
authors.forename: G
authors.initials: G
authors.lastname: Pfurtscheller
authors.forename: L
authors.initials: L
authors.lastname: Saltuari
authors.forename: T
authors.initials: T
authors.lastname: Schmid
authors.forename: D
authors.initials: D
authors.lastname: Ofner
authors.forename: G
authors.initials: G
authors.lastname: Klima
authors.forename: R
authors.initials: R
authors.lastname: Margreiter
mesh_terms: D000200:Action Potentials; D000818:Animals; D004576:Electromyography; D006084:Graft Rejection / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology* / Q000637:transplantation*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous