title: Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain.
abstract: Quantitative in situ hybridization analysis of catalytic (trkB TK+) and non-catalytic (trkB TK-) trkB mRNAs in the postnatal rat brain demonstrated regional differences in expression and revealed transient increases in trkB TK+ expression. Hybridization of trkB TK+ mRNA was observed in thalamic nuclei between P4 and P8, but not in the adult. In hippocampal structures, transient elevations of trkB TK+ mRNA were apparent between P13 and P17. In contrast, there was a gradual developmental increase in trkB TK- mRNA expression in the hippocampus.
authors.affiliation: Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
authors.forename: M M
authors.initials: MM
authors.lastname: Dugich-Djordjevic
authors.forename: F
authors.initials: F
authors.lastname: Ohsawa
authors.forename: F
authors.initials: F
authors.lastname: Hefti
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D017403:In Situ Hybridization; D009414:Nerve Growth Factors / Q000096:biosynthesis; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D020933:Neurotrophin 3; D011247:Pregnancy; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis*; D013462:Sulfur Radioisotopes; D013787:Thalamic Nuclei / Q000254:growth & development / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3; D015347:RNA Probes; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; C071951:neurotrophin 5; D020794:Receptor Protein-Tyrosine Kinases; C073922:neurotrophin 4