[Effects of jiang tang tong mai ning on serum ascorbyl radical, superoxide dismutase activity, lipid peroxide level and tissue free oxygen radical in diabetic rats].
The effect of Jiang Tang Tong Mai Ning treatment on body weight, the level of blood sugar, the serum ascorbyl radical, SOD activity, LPO level and peroxidic radial (O2.-) of heart and kidney tissue in alloxan induced diabetic rats were observed. The results were also compared with that of Jiang Tang Jia Pian and vitamin E treated groups, which showed that the level of blood sugar, the level of serum ascorbyl radical, the concentration of LPO and peroxidic radical (O2.-) of myocardium and kidney tissue decreased significantly respectively (P < 0.01, 0.01, 0.01, 0.05), and the body weight, SOD activity increased obviously after the treatment (P < 0.05). For the first time, a W-wave between S-peak and T-peak of ESR spectrum in the tissue of rat, which is similar to the form of Fe-Mo-flavoprotein has been observed in this investigation, a positive correlation appears to exist between A value and the corresponding G value of W-wave.
Su
A F
AF
Guang An Men Hospital, China Academy of TCM, Beijing.
Lu
J F
JF
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005609:Free Radicals; D007668:Kidney / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005609:Free Radicals; D008054:Lipid Peroxides; D013482:Superoxide Dismutase; D001205:Ascorbic Acid