[Experimental and clinical studies of the action of verapamil (finoptin) on the cerebral circulation in transient cerebral ischemia].
The experiments on unanesthetized rats have established that the intravenous injection of verapamil in a dose of 0.6 mg/kg during 30-minute carotid occlusion with subsequent recirculation prevents postischemic hypoperfusion, normalized oxidative processes and prevents brain tissue edema. In patients with transient cerebral circulatory disorders, a single injection of verapamil in a dose of 10 mg enhances the pulse filling of cerebral vessels. During a course therapy, the drug decreases minor and middle vessel tone, increases the REG amplitude, lowers the interhemispheric asymmetric blood filling rate, and enhances the functional resistance of cerebral vessels.
Miller
L G
LG
Zakharova
M A
MA
Burtsev
E M
EM
Savkov
V S
VS
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D051381:Rats; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use*
D002245:Carbon Dioxide; D014700:Verapamil; D010100:Oxygen
Eksperimental'noe i klinicheskoe issledovanie deĭstviia verapamila (finoptina) na mozgovoe krovoobrashchenie pri tranzitornoĭ tserebral'noĭ ishemii.