Molecular remission after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.
A 51-year-old man with previously treated CLL received an allogeneic sex mismatched BMT after total body irradiation and high dose chemotherapy. Residual disease was studied at phenotypic and molecular levels including Y chromosome DNA amplification by PCR assay. The patient was clinically disease-free 20 months after BMT with disappearance of the leukemic clone assessed by the most sensitive methods of detection. Long-term follow-up is necessary to ascertain the relevance of Y DNA amplification in predicting outcome in this patient.
Sadoun
A
A
Hôpital Jean Bernard, Département d'Hématologie et Oncologie Médicale, Poitiers, France.
Patri
S
S
Delwail
V
V
Chomel
J C
JC
Cogne
M
M
Brizard
A
A
Kitzis
A
A
Guilhot
F
F
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001483:Base Sequence; D015139:Blotting, Southern; D016026:Bone Marrow Transplantation; D004273:DNA, Neoplasm / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012074:Remission Induction; D014916:Whole-Body Irradiation; D014998:Y Chromosome
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm