The uptake of fenbendazole by cattle and buffalo following long-term low-level administration in urea-molasses blocks.
Fenbendazole (Panacur bolus, Hoechst India Ltd) was incorporated at a rate of 0.5 g/kg into urea-molasses blocks made by two different processes. The concentration of the drug in blocks and its bioavailability were measured using plasma oxfendazole as marker. The recovery of the drug in blocks made by a warm process was 68% and the plasma oxfendazole concentration remained fairly stable at 0.2 and 0.12 microgram/ml from day 6 of feeding in cattle and buffalo, respectively. The drug seemed to be inactivated in blocks made by a hot process, with reduced bioavailability. A low and sustained plasma concentration of the active metabolite of the drug could be maintained by self-medication using urea-molasses blocks as fenbendazole carrier.
Sanyal
P K
PK
Animal Disease Research Laboratory, National Dairy Development Board, Anand, Gujarat, India.
Singh
D K
DK
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001682:Biological Availability; D002020:Buffaloes / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D005273:Fenbendazole / Q000493:pharmacokinetics*; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male
D005273:Fenbendazole