Ability of hydroxyapatite-bone morphogenetic (corrected from morphologenetic) protein (BMP) complex to induce dentin formation in dogs.
This histological investigation examined the formation and differentiation of pulp cells under the influence of HAP/BMP complex. HAP/BMP complex was implanted in exposed pulp of the mandibular premolars and alveolar bone defect in the dog. Sequential changes in these areas were examined mainly under a light microscope and partly under a scanning electron microscope. Two weeks after the operation, fibroblast-like cells proliferated right beneath the implanted complex, and after 3 weeks, dentin including dentin tubules grew in the pulp. After four weeks a dentin bridge composed of osteoid dentin was found, and after 8 weeks this dentin calcified and covered the defective surface of the root and adhered to new bone surrounding the HAP granules. The results indicated that the dentin induced by HAP/BMP complex may be of two types: tubular dentin and osteodentin. This complex exhibited outstanding ability to induce dentinogenesis and osteogenesis.
Suwa
F
F
Department of Anatomy, Osaka Dental University, Japan.
Yang
L
L
Ohta
Y
Y
Fang
Y R
YR
Ike
H
H
Deguchi
T
T
D000818:Animals; D019485:Bone Morphogenetic Proteins; D002454:Cell Differentiation; D002455:Cell Division; D003782:Dental Pulp / Q000166:cytology; D003804:Dentin / Q000166:cytology; D003810:Dentinogenesis / Q000502:physiology*; D004285:Dogs; D017886:Durapatite; D008297:Male; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000502:physiology*; D011506:Proteins / Q000502:physiology*
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D017886:Durapatite