title: Long-term use of anti-D in chronic idiopathic thrombocytopenic purpura.
abstract: Chronic idiopathic thrombocytopenic purpura is an autoimmune disease characterized by antibody-mediated destruction of platelets. To maintain the platelets above the symptomatic level, we administered anti-D (100 micrograms for 5 consecutive days) in 19 children with idiopathic thrombocytopenic purpura (ITP). Four patients did not respond to treatment. Fifteen responded with an increase in the average platelet number to 76,000/microL on the 7th postinjection day. Within 45 days, however, platelets dropped to 27,000/microL. Three months after this study, two patients from the study group were re-administered anti-D in daily injections for 5 consecutive days, as was done previously. Monthly administration of anti-D in two patients maintained platelets above 30,000/microL for periods of five and six months. We concluded that monthly administration of anti-D after five consecutive daily injections can maintain platelet levels above the symptomatic level and may provide a corticosteroid-free safe interval of nearly five months.
authors.affiliation: Department of Pediatrics, SSK Tepecik Teaching Hospital, Izmir.
authors.forename: I
authors.initials: I
authors.lastname: Yaprak
authors.forename: S
authors.initials: S
authors.lastname: Cağlayan
authors.forename: S
authors.initials: S
authors.lastname: Kansoy
authors.forename: E
authors.initials: E
authors.lastname: Ozdoğru
authors.forename: A R
authors.initials: AR
authors.lastname: Bakiler
authors.forename: H
authors.initials: H
authors.lastname: Aydinlioğlu
mesh_terms: D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000627:therapeutic use*; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D012204:Rh-Hr Blood-Group System / Q000627:therapeutic use*; D018029:Rho(D) Immune Globulin; D016896:Treatment Outcome
chemical_list: D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin