Age-dependent decreases in fibrinolytic enzyme activities in serum of healthy subjects.
We investigated the age-dependency of serum levels of 9 kinds of proteases. The results showed that the enzymatic activities corresponding to urokinase, plasmin, and thrombin, all involved in blood clotting and fibrinolysis, were inversely correlated with age. This suggests that there is some similarity between the normal process of aging and the pathologic process of Alzheimer's disease. Compared with our previous data on Alzheimer patients, the present results indicate that some derangement in the aging process is involved in the pathogenetic mechanisms of Alzheimer's disease.
Aoyagi
T
T
Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Wada
T
T
Kojima
F
F
Nagai
M
M
Harada
S
S
Takeuchi
T
T
D000375:Aging / Q000097:blood*; D000544:Alzheimer Disease / Q000201:enzymology; D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000097:blood; D010450:Endopeptidases / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis; D043384:Glutamyl Aminopeptidase; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D007931:Leucyl Aminopeptidase / Q000097:blood; D001121:Lysine Carboxypeptidase / Q000097:blood; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D013917:Thrombin / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D010450:Endopeptidases; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; C019721:aminopeptidase B; D043384:Glutamyl Aminopeptidase; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D007610:Kallikreins; D013917:Thrombin; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator