title: The major histocompatibility complex in man.
abstract: The HLA system is a complex of polymorphic genes divided into a class I group and a class II group. The disclosed tertiary structure of HLA antigens indicates that they are principally involved in binding a variety of self and foreign immunogenic peptides and in their presentation to T cells. Class III HLA region is located between class I and class II regions. It comprises many genes, some of them participate in events of the immune response, too.
authors.affiliation: Department of Immunology, Faculty of Medicine, Comenius University, Bratislava.
authors.forename: M
authors.initials: M
authors.lastname: Buc
mesh_terms: D017951:Antigen Presentation / Q000276:immunology; D005075:Biological Evolution; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology*; D017434:Protein Structure, Tertiary; D018089:Superantigens / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D018089:Superantigens