[Antimycotic agents. 20. Bioisoteric 6-arylpyrimidine derivatives].
Condensation of N-(2-hydroxyethyl)-N-methylguanidine-sulfate (1) with the beta-diketones 4a-e bearing 1-aryl substituents leads to the bioisosteric 2-[(2-hydroxyethyl)-methylamino]-6-arylpyrimidines 5a-e. Compounds 5a-c exhibit significant antimycotic in vivo and in vitro activities.
Kreutzberger
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Institut für Pharmazie, Johannes Gutenberg-Universität Mainz.
Burger
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D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D011743:Pyrimidines
Antimykotische Wirkstoffe, 20. Mitt.: Bioisostere 6-Arylpyrimidin-Derivate.