title: Topical aspirin in chloroform and the relief of pain due to herpes zoster and postherpetic neuralgia.
abstract: OBJECTIVE
  To determine pain patterns and relationships in patients with herpes zoster and postherpetic neuralgia before and after topical application of aspirin dissolved in chloroform applied to the painful skin surface.
  
  
  METHODS
  A consecutive series of 42 patients examined and treated in a uniform manner and followed up until their pain subsided or this management mode failed.
  
  
  METHODS
  An ambulatory referral private practice.
  
  
  METHODS
  All patients had pain due to herpes zoster or postherpetic neuralgia and were referred for management of severe pain. None refused.
  
  
  METHODS
  Topical application of crushed aspirin tablets dissolved in chloroform.
  
  
  METHODS
  Short-Form McGill Pain Questionnaire.
  
  
  RESULTS
  All patients reported substantially decreased pain promptly after treatment, with maximum relief at 20 to 30 minutes and lasting 2 to 4 hours. Patients gradually decreased the use of aspirin in chloroform as pain abated.
  
  
  CONCLUSIONS
  Topical aspirin dissolved in chloroform is an effective means of reducing pain due to herpes zoster and postherpetic neuralgia in most patients. The locus of pain origin and analgesia induced by topical aspirin is most likely at cutaneous free-nerve ending pain receptors. The mechanism responsible for the analgesic properties of aspirin is probably not the same as that responsible for its anti-inflammatory properties.
authors.affiliation: Department of Neurosurgery, State University of New York Health Science Center, Syracuse, NY 13210.
authors.forename: R B
authors.initials: RB
authors.lastname: King
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage*; D002725:Chloroform / Q000008:administration & dosage*; D005260:Female; D006562:Herpes Zoster / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D013607:Tablets
chemical_list: D013607:Tablets; D002725:Chloroform; D001241:Aspirin