title: Activity oscillations predicted for pyruvate dehydrogenase complexes.
abstract: A kinetic model for the pyruvate dehydrogenase complex is analyzed. The model takes into account intermediate channeling through the lipoyl network attached to the complex core, as well as inter-related regulatory effects of protein X acetylation and enzyme phosphorylation. The model predicts undamped oscillations of enzyme activity.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region.
authors.forename: V A
authors.initials: VA
authors.lastname: Selivanov
authors.forename: D T
authors.initials: DT
authors.lastname: Zakrzhevskaya
authors.forename: B N
authors.initials: BN
authors.lastname: Goldstein
mesh_terms: D007700:Kinetics; D008433:Mathematics; D008962:Models, Theoretical; D009991:Oscillometry; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011768:Pyruvate Dehydrogenase Complex