title: [The distribution of hematoporphyrin derivatives in the animal body].
abstract: The pharmacokinetic distribution of haematoporphyrin derivative (HPD) and synthetic oligomeric haematoporphyrin (OG) which showed various lipophilicity was studied in animal tumor and normal tissues. The accumulation of dyes in tissue and their tumor-seeking capacity depended on the degree of polymerization, lipophilicity, and ratio of dye components. The difference in the absolute concentrations of HPD and OG (6.9 and 16.1 micrograms per g tissue, respectively) in tumor after dye injection in an adequate concentration (10 mg/kg b. w.) indicates that synthetic OG is beneficial for tumor diagnosis and photodynamic therapy.
authors.forename: A S
authors.initials: AS
authors.lastname: Seĭlanov
authors.forename: V M
authors.initials: VM
authors.lastname: Pyzhik
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Seĭlanova
authors.forename: A F
authors.initials: AF
authors.lastname: Mironov
authors.forename: I V
authors.initials: IV
authors.lastname: Deriuzhenko
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D017323:Dihematoporphyrin Ether / Q000032:analysis / Q000493:pharmacokinetics; D017324:Hematoporphyrin Derivative / Q000032:analysis / Q000493:pharmacokinetics*; D009368:Neoplasm Transplantation; D051381:Rats; D012016:Reference Values; D012513:Sarcoma, Experimental / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D017324:Hematoporphyrin Derivative; D017323:Dihematoporphyrin Ether
vernacular_title: Raspredelenie proizvodnykh gematoporfirina v organizme zhivotnykh.