title: Effect of immune serum, an antibiotic, and a corticosteroid used alone or in combination on experimental leptospirosis in Mongolian gerbils (Meriones unguiculatus).
abstract: We studied the effects of immune sera, an antibiotic, and a corticosteroid used alone or in combination on leptospira infection in Mongolian gerbils (Meriones unguiculatus). The results suggest that the combined used of immune serum and corticosteroid (pledonizoron: PZ) inhibits the effects of serum and the marked effects of antibiotic (procaine penicillin-G: PC-G) on leptospirosis. PZ had no effects and rather shortened the survival period. PZ did not affect the effects of PC-G when used in combination. These results suggest that treatment of leptospirosis with corticosteroids requires special caution.
authors.affiliation: Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yukawa
authors.forename: H
authors.initials: H
authors.lastname: Kamata
authors.forename: S
authors.initials: S
authors.lastname: Ohba
authors.forename: K
authors.initials: K
authors.lastname: Kadoi
authors.forename: K
authors.initials: K
authors.lastname: Mochizuki
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005849:Gerbillinae; D007106:Immune Sera; D007922:Leptospirosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D007106:Immune Sera