title: Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol.
abstract: A 61-d study involving 40 crossbred lambs evaluated the effect of various forms of tocopherol provided daily in equimolar amounts on total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in the serum of lambs. Thirty-five lambs were allotted to 7 treatment groups of 5 animals each, supplemented with 300 mg tocopherol either as: 1) DL-alpha-tocopheryl acetate; 2) D-alpha-tocopheryl acetate; 3) D-alpha-tocopheryl succinate; 4) D-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS); 5) DL-alpha-tocopheryl nicotinate; 6) DL-alpha-tocopheryl nicotinate (150 mg) + 150 mg TPGS; and 7-D-alpha-tocopheryl acetate (150 mg) + 150 mg TPGS mixed with the commercial flock diet. In addition, another group of 5 lambs were used as control (no vitamin E supplementation). Dietary supplementation of various vitamin E sources resulted in no overall treatment effects for total cholesterol, triglycerides or high density lipoprotein-cholesterol. A significant variation was noticed among animals. The levels of all measured serum components varied throughout the experimental period (P < 0.0001). The day x treatment interaction was not significant (P > 0.05) for any serum measured component. The present data strongly suggest that short-term treatment (< 2 mo) with pharmacological oral doses of various forms of vitamin E did not influence serum lipid metabolism of lambs. The data also showed that the bioavailability of alpha-tocopherol is dependent on the form administered. D-alpha-tocopherol acetate is a highly available form, the bioavailability of which is further increased when combined with D-alpha-tocopheryl polyethylene glycol succinate.
authors.affiliation: University of Florida, Department of Animal Science, Gainesville 32611.
authors.forename: N
authors.initials: N
authors.lastname: Hidiroglou
authors.forename: M S
authors.initials: MS
authors.lastname: Wolynetz
authors.forename: L R
authors.initials: LR
authors.lastname: McDowell
authors.forename: A M
authors.initials: AM
authors.lastname: Papas
authors.forename: M
authors.initials: M
authors.lastname: Antapli
authors.forename: N S
authors.initials: NS
authors.lastname: Wilkinson
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D009539:Nicotinic Acids / Q000494:pharmacology; D011092:Polyethylene Glycols; D012756:Sheep / Q000097:blood*; D024505:Tocopherols; D014280:Triglycerides / Q000097:blood*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D008076:Cholesterol, HDL; D009539:Nicotinic Acids; D014280:Triglycerides; D014810:Vitamin E; D011092:Polyethylene Glycols; C012581:alpha-tocopheryl nicotinate; D002784:Cholesterol; D024502:alpha-Tocopherol; C014225:tocophersolan; D024505:Tocopherols