[DNA damages caused by paracetamol].
Studies on cells in vitro and animal experiments show that paracetamol may bind covalently to DNA, inhibit DNA-replication and DNA-repair synthesis, and cause chromosomal aberrations in somatic cells. In two studies a higher level of chromosomal aberrations was found in lymphocytes after exposure of human volunteers to therapeutic doses of paracetamol, but in a third study the results were negative. Genotoxic effects of paracetamol have been demonstrated both in vitro and in vivo at or near therapeutic concentrations. Overall, the data indicate that paracetamol-use may contribute to an increase in the total burden of DNA-damage in man. Higher risk of cancer after exposure to paracetamol has not been demonstrated in epidemiological studies, nor has increased risk of cancer been unequivocally documented from animal experiments. It is generally accepted, however, that exposure that may cause DNA-damage in man should be reduced and if possible avoided. The therapeutic benefit of using paracetamol should therefore be carefully evaluated, taking into consideration its potential for inducing acute and chronic and genotoxic effects.
Hongslo
J K
JK
Seksjon for produkttoksikologi Avdeling for Miljømedisin Statens Institutt for Folkehelse, Oslo.
Holme
J A
JA
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity; D000818:Animals; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced / Q000235:genetics; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012307:Risk Factors
D000082:Acetaminophen
DNA-skader av paracetamol.