[Can processes connected to muscular activity explain development of chronic pain?].
The pathogenetic mechanisms of chronic muscle pain are not known, but may be related to incomplete recovery between bouts of work. During monotonous repetitive static muscle contraction, fatigue develops gradually, parallel to an increase in oxidative metabolism combined with a change in Ca(2+)-homeostasis in a few muscle fibres. Ischemia or high lactate probably do not contribute to fatigue in this state. We review some recent results on muscle fatigue during a low force static work situation and also discuss the significance of K+ released from muscle as an important extracellular messenger.
Saugen
E
E
Arbeidsfysiologisk seksjon Statens arbeidsmiljøinstitutt, Oslo.
Hallén
J
J
Bjørklund
U H
UH
Vøllestad
N K
NK
Sejersted
O M
OM
D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D004734:Energy Metabolism; D006801:Humans; D009119:Muscle Contraction; D009140:Musculoskeletal Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D010146:Pain / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D011188:Potassium / Q000378:metabolism
D011188:Potassium; D002118:Calcium
Kan prosesser knyttet til muskeltretthet forklare utvikling av kronisk smerte?