Serum osteocalcin concentration in horses treated with triamcinolone acetonide.
The effect of triamcinolone acetonide (0.09 mg/kg of body weight, IM) on serum osteocalcin concentration was studied. Two groups of horses were investigated and included clinically normal horses (group 1, n = 5) and horses with chronic obstructive pulmonary disease (group 2, n = 5). Before treatment, results of a t-test did not reveal any significant difference in serum osteocalcin concentration between the 2 groups. After treatment, a significant (P < 0.05) decrease in serum osteocalcin concentration was observed for both groups. Osteocalcin concentration in individual horses reached a minimum by 24 to 48 hours after treatment. In both groups of horses, serum osteocalcin response to glucocorticoid administration was similar. In 7 of 10 horses, return to pretreatment values was observed after 28 days. Pretreatment values for the other 3 horses were reached between 62 and 150 days.
Lepage
O M
OM
Département de Médecine, Faculté de Médecine Vétérnaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
Laverty
S
S
Marcoux
M
M
Dumas
G
G
D000818:Animals; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000188:drug therapy*; D006736:Horses / Q000097:blood*; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D015675:Osteocalcin / Q000097:blood / Q000187:drug effects*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D015675:Osteocalcin; D014222:Triamcinolone Acetonide