title: A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 1. A review of the epidemiology and control of malaria in The Gambia, west Africa.
abstract: Malaria was recognized as an important cause of death among early European visitors to The Gambia, but the infection was first studied systematically in the local population only in the 1950s. Studies undertaken in the village of Keneba at that time showed that nearly all children under the age of 5 years had parasitaemia throughout the year. More recent surveys in rural areas of The Gambia have shown much lower levels of parasitaemia, probably as a result of a decline in rainfall in The Gambia during the past 30 years and because of an increase in the availability of anti-malarial drugs. Nevertheless, community surveys and reviews of hospital statistics show that malaria is still one of the most important causes of death among Gambian children; about 1 in 25 rural Gambian children die from malaria before reaching the age of 5 years. Until recently, malaria control in The Gambia relied upon prompt treatment of clinical attacks, first with quinine and more recently with chloroquine, and upon some limited vector control in the capital, Banjul. However, during the past few years, it has been shown that mortality in rural children can be reduced substantially by means of chemoprophylaxis given by village health workers. Bed nets (mosquito nets) are used widely in The Gambia and epidemiological surveys have shown an association between the use of bed nets and protection against malaria. This observation led to a series of small scale intervention trials.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
authors.forename: B M
authors.initials: BM
authors.lastname: Greenwood
authors.forename: H
authors.initials: H
authors.lastname: Pickering
mesh_terms: D000367:Age Factors; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002675:Child, Preschool; D005714:Gambia / Q000453:epidemiology; D049673:History, 20th Century; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007303:Insect Vectors; D008288:Malaria / Q000453:epidemiology* / Q000266:history / Q000401:mortality / Q000517:prevention & control; D009017:Morbidity; D009032:Mosquito Control; D011891:Rain; D012621:Seasons; D013997:Time Factors; D014504:Urban Health
chemical_list: D000962:Antimalarials