title: Synthesis and antimicrobial evaluation of novel oxa(thia)diazolylquinolines and oxa(thia)diazepino[7,6-b] quinolines.
abstract: Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3[(substituted)thiocarbamoyl-hydrazonomethyl]-2-chloroquinoline s and 3-aroylhydrazonomethyl-2-chloroquinolines: 3-(3-Acetyl-5-(substituted)-2,3-dihydro-1,3,4-oxa(thia)diazol-2-yl )-2- chloroquinolines (4; 5), 3-(5-(substituted)-1,3,4-oxa(thia)diazol-2-yl)-2-chloroquinolin es (6; 7), and 2-(substituted)-1,3,4-oxa(thia)diazepino[7,6-b]quinolines (8; 9). The antimicrobial activity of these compounds was studied.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Khalil
authors.forename: O A
authors.initials: OA
authors.lastname: el-Sayed
authors.forename: H A
authors.initials: HA
authors.lastname: el-Shamy
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D001381:Azepines; D010069:Oxadiazoles; D011804:Quinolines; D013830:Thiadiazoles