Stage IIb cervical carcinoma: MR evaluation of effect of intraarterial chemotherapy.
OBJECTIVE
To evaluate magnetic resonance (MR) imaging in assessment of tumor response after intraarterial chemotherapy (IAC) in cervical carcinoma.


METHODS
MR images of 19 patients who underwent IAC because of stage IIb cervical carcinoma were prospectively analyzed and compared with pathologic findings. Three courses of IAC were administered, and MR images were obtained before and after treatment. Extent of reduction of tumor volume determined eligibility for surgery. MR images of 17 patients who were candidates for surgery were correlated with pathologic specimens.


RESULTS
Average reduction in tumor volume was 88.5%. Response to IAC was complete in seven patients, partial in 11, and minor in one. MR imaging findings after IAC correlated well with pathologic findings.


CONCLUSIONS
MR imaging is useful in assessment of tumor response to IAC and provides criteria for decision making with regard to further radiation or surgical therapy.
Kim
K H
KH
Department of Diagnostic Radiology, Korea Cancer Center Hospital, Seoul.
Lee
B H
BH
Do
Y S
YS
Chin
S Y
SY
Park
S Y
SY
Kim
B G
BG
Jang
J J
JJ
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology