Urinary acidification and urinary excretion of calcium and citrate in women with bilateral medullary sponge kidney.
Urinary acidification ability, acid-base status and urinary excretion of calcium and citrate were evaluated in 10 women with bilateral medullary sponge kidney (MSK) and in 10 healthy women. Patients with MSK had higher fasting urine pH compared to normal controls (p < 0.01). Four patients had incomplete renal tubular acidiosis (iRTA), 3 had hypercalciuria, and 5 patients had hypocitraturia. The 24-hour urinary excretion of calcium was increased in the females with MSK (5.23 +/- 0.78 mmol) compared to the healthy females (3.49 +/- 0.29 mmol) (p < 0.02), and increased in MSK patients with iRTA (7.32 +/- 1.45 mmol) compared to patients with normal urinary acidification (3.83 +/- 0.12 mmol) (p < 0.01). The patients with iRTA had reduced levels of plasma standard bicarbonate (20.5 +/- 1.0) after fasting compared to patients with normal urinary acidification (23.8 +/- 0.8) and healthy women (22.7 +/- 0.6) (p < 0.01), and reduced levels of 24-hour urinary excretion of citrate (0.93 +/- 0.25 mmol) compared to patients with normal urinary acidification (3.58 +/- 0.51) and healthy women (2.78 +/- 0.49) (p < 0.005). A positive correlation was found between the degree of acidosis during ammonium chloride loading and urinary excretion of calcium (r = 0.71, p = 0.02), and a negative correlation between the degree of acidosis during ammonium chloride loading and urinary citrate excretion (r = 0.87, p = 0.001). The results suggest that defective urinary acidification might play an important role in the mechanism of hypercalciuria and hypocitraturia in patients with medullary sponge kidney.(ABSTRACT TRUNCATED AT 250 WORDS)
Osther
P J
PJ
Department of Urology, University Hospital, Odense, Denmark.
Mathiasen
H
H
Hansen
A B
AB
Nissen
H M
HM
D000141:Acidosis, Renal Tubular / Q000097:blood / Q000209:etiology / Q000652:urine*; D000328:Adult; D000643:Ammonium Chloride / Q000494:pharmacology; D000863:Antacids / Q000652:urine*; D001639:Bicarbonates / Q000097:blood; D002118:Calcium / Q000652:urine*; D002951:Citrates / Q000652:urine*; D019343:Citric Acid; D005215:Fasting; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007679:Kidney Medulla / Q000187:drug effects / Q000473:pathology; D007691:Medullary Sponge Kidney / Q000097:blood / Q000150:complications / Q000473:pathology / Q000652:urine*; D008875:Middle Aged
D000863:Antacids; D001639:Bicarbonates; D002951:Citrates; D000643:Ammonium Chloride; D019343:Citric Acid; D002118:Calcium