Pharmacological screening of plants recommended by folk medicine as snake venom antidotes; IV. Protection against jararaca venom by isolated constituents.
Fifteen compounds, isolated from plants reputed as snake venom antidotes, belonging to different classes of natural products, were shown to protect mice to a significant degree against the lethal action of the venom of Bothrops jararaca snakes. Administration was by the oral route, one hour prior to envenomation. The substances are nitrogen-free, low-molecular-weight compounds for which some kind of biodynamic activity has previously been reported. The fact that they are mostly trivial, naturally-occurring compounds should explain why plants used as snake-bite antidotes are so widely distributed over the plant kingdom.
Pereira
N A
NA
Departamento de Farmacologia, CCS-ICB, Universidade Federal do Rio de Janeiro, Brasil.
Pereira
B M
BM
do Nascimento
M C
MC
Parente
J P
JP
Mors
W B
WB
D000818:Animals; D000931:Antidotes; D017837:Bothrops; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors*; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
D000931:Antidotes; D003435:Crotalid Venoms; D010936:Plant Extracts