The utilization of quantitative trait loci in toxicogenetics.
With the increasing number of marker loci available in mouse, the traditional method of recombinant inbred strains can be extended to searches for quantitative trait loci (QTL) influencing continuously distributed phenotypes. These loci have effect sizes too small to be easily detectable by conventional single-locus techniques. Collective, several QTL may account for a substantial proportion of the phenotypic variability. Prospective advantages of location of QTL in toxicology-relevant phenotypes include opportunities for the study of mechanism, prospects of generating animal models by genotypic selection, study of the dynamics of gene interaction, and guiding the search for homologous genes in human beings.
McClearn
G E
GE
Center for Developmental and Health Genetics, College of Health and Human Development, Pennsylvania State University, University Park 160801.
Jones
B
B
Blizard
D A
DA
Plomin
R
R
D000483:Alleles; D000818:Animals; D005819:Genetic Markers; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods*; D010641:Phenotype
D005819:Genetic Markers