title: Herpes simplex type 1 encephalitis in acquired immunodeficiency syndrome.
abstract: A severe acute necrotizing herpes simplex virus type 1 encephalitis, apparently mediated by macrophages or cytokines or both, was seen in a patient with acquired immunodeficiency syndrome. The necrosis had a distribution similar to that seen in immunocompetent subjects. Viral inclusions were abundant and meningeal reaction was minimal, as previously described in one anergic patient.
authors.affiliation: Department of Neurology, Westminster Hospital, London.
authors.forename: S V
authors.initials: SV
authors.lastname: Tan
authors.forename: R J
authors.initials: RJ
authors.lastname: Guiloff
authors.forename: F
authors.initials: F
authors.lastname: Scaravilli
authors.forename: P E
authors.initials: PE
authors.lastname: Klapper
authors.forename: G M
authors.initials: GM
authors.lastname: Cleator
authors.forename: B G
authors.initials: BG
authors.lastname: Gazzard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D000328:Adult; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D004660:Encephalitis / Q000150:complications / Q000473:pathology*; D006561:Herpes Simplex / Q000150:complications / Q000473:pathology*; D018259:Herpesvirus 1, Human / Q000235:genetics; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral