title: Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetes.
abstract: In a screening for nematicidal activities in cultures of Basidiomycetes, cultures of Pleurotus pulmonarius and Hericium coralloides exhibited toxic effects towards the saprophytic nematode Caenorhabditis elegans. Subsequently S-coriolic acid (1), linoleic acid (2), p-anisaldehyde (3), p-anisyl alcohol (4), 1-(4-methoxyphenyl)-1,2-propanediol (5), and 2-hydroxy-(4'-methoxy)-propiophenone (6) were isolated from submerged cultures of P. pulmonarius. All compounds showed nematicidal activities towards C. elegans. The most active compounds were 1 and 2 with LD50 values between 5 and 10 ppm. Compounds 1, 4, and 5 have not been previously isolated from higher fungi, 6 is a new natural product. From cultures of H. coralloides, which exhibited both repellant and nematicidal effects, a nematicidal fatty acid mixture was obtained, containing linoleic acid, oleic acid, and palmitic acid as its main components.
authors.affiliation: Lehrbereich Biotechnologie, Universität Kaiserslautern, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Stadler
authors.forename: A
authors.initials: A
authors.lastname: Mayer
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D017173:Caenorhabditis elegans / Q000187:drug effects; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011124:Polyporaceae / Q000737:chemistry
chemical_list: D000969:Antinematodal Agents; D005227:Fatty Acids