title: Carbamazepine affects triiodothyronine production and metabolization in rat hippocampus.
abstract: The effects of subchronic administration of carbamazepine on thyroid hormone metabolism were investigated in the hippocampus in adult male rats at two different measuring times (4 a.m. and 8 p.m.). Carbamazepine enhanced the activity of 5'II-deiodinase, which catalyzes the deiodination of the prohormone T4 to the active compound T3, at 8 p.m., but not at 4 a.m. The activity of 5III-deiodinase, which catalyzes the further deiodination of the active hormone T3 to its metabolite 3,3'T2, was inhibited at 4 a.m. but not at 8 p.m. These effects of carbamazepine on intracellular thyroid hormone metabolism in the hippocampus should theoretically lead to a rise in T3 production. It remains to be investigated whether they are somehow involved in the as yet unknown mechanisms underlying the anticonvulsant/mood-stabilizing effects of carbamazepine.
authors.affiliation: Psychiatric Clinic, Universitätsklinikum Rudolf-Virchow, Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Baumgartner
authors.forename: A
authors.initials: A
authors.lastname: Campos-Barros
authors.forename: U
authors.initials: U
authors.lastname: Gaio
authors.forename: C
authors.initials: C
authors.lastname: Hessenius
authors.forename: A
authors.initials: A
authors.lastname: Flechner
authors.forename: H
authors.initials: H
authors.lastname: Meinhold
mesh_terms: D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007453:Iodide Peroxidase / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014284:Triiodothyronine / Q000378:metabolism*
chemical_list: D014284:Triiodothyronine; D002220:Carbamazepine; D007453:Iodide Peroxidase