A novel role for the nitric oxide-cGMP signaling pathway: the control of epithelial function in Drosophila.
The nitric oxide (NO) signaling pathway plays major roles in the vertebrate vascular, nervous, and immune systems. Here we present evidence that all the elements in the NO pathway are present in, and act to control epithelial fluid secretion by, the Malpighian tubules of an insect, Drosophila melanogaster. This finding will allow both a physiological and a molecular genetic dissection of the NO pathway in the same tissue.
Dow
J A
JA
Department of Cell Biology, University of Glasgow, United Kingdom.
Maddrell
S H
SH
Davies
S A
SA
Skaer
N J
NJ
Kaiser
K
K
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism* / Q000494:pharmacology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000096:biosynthesis / Q000378:metabolism; D004331:Drosophila melanogaster / Q000502:physiology*; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects; D006706:Homeostasis; D008317:Malpighian Tubules / Q000187:drug effects / Q000502:physiology*; D009252:NADPH Dehydrogenase / Q000032:analysis / Q000378:metabolism; D009569:Nitric Oxide / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D012333:RNA, Messenger; D009599:Nitroprusside; D009569:Nitric Oxide; D009252:NADPH Dehydrogenase; D017869:Cyclic GMP-Dependent Protein Kinases; D010749:Phosphoprotein Phosphatases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D006152:Cyclic GMP