[The effect of dalargin on the course of experimental cardiac arrhythmias].
Five models of arrhythmias (aconitine-, calcium chloride- and low-sodium-induced models on rats, coronary artery ligation and reperfusion in dogs) were used to study the antiarrhythmic and antifibrillatory effects. The latters were not inferior to those shown by the well-known antiarrhythmics. The mechanisms of the action of dalargin are discussed in the paper.
Grekova
T I
TI
Reznikov
K M
KM
Vinokurova
O V
OV
Kireeva
A A
AA
Taratinova
T I
TI
Nikolaevskiĭ
V A
VA
Shchetinkina
N A
NA
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D002122:Calcium Chloride; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008012:Lidocaine / Q000627:therapeutic use; D009020:Morphine / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine; D008012:Lidocaine; D002122:Calcium Chloride; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D000157:Aconitine
Vliianie dalargina na techenie éksperimental'nykh aritmiĭ serdtsa.