title: Multiply pulsed collision gas for ion axialization in Fourier-transform ion cyclotron resonance mass spectrometry.
abstract: We present a new multiply pulsed collision-gas technique for ion axialization for Fourier-transform ion cyclotron resonance (FTICR) high-resolution mass analysis. Ions are axialized in the source trap of a dual-trap FTICR spectrometer by azimuthal quadrupolar irradiation for several tens of seconds at a steady-state pressure maintained by repeated pulses of collision gas (argon), followed by removal of the collision gas and detection at a much lower pressure after transfer to the analyzer trap. Magnitude-mode FTICR mass resolving power, m/delta m approximately 1,770,000, for [M+K]+ ions from laser-desorbed/ionized leucine enkephalin at m/z 594 is demonstrated. This mass resolving power is the highest yet reported for a peptide with any type of laser desorption/ionization mass analyzer.
authors.affiliation: Department of Chemistry, Ohio State University, Columbus 43210.
authors.forename: S
authors.initials: S
authors.lastname: Guan
authors.forename: A G
authors.initials: AG
authors.lastname: Marshall
mesh_terms: D001128:Argon; D017357:Cyclotrons; D004743:Enkephalin, Leucine / Q000032:analysis; D005583:Fourier Analysis; D013058:Mass Spectrometry / Q000295:instrumentation*
chemical_list: D004743:Enkephalin, Leucine; D001128:Argon