title: [A combination of spermatocytic and classic seminoma, mature teratoma and carcinoma in situ of the testis. An attempt at an etiologic explanation].
abstract: We report of a 39 years old patient with a large testicular tumor found during an examination for infertility. The tumor consisted of a spermatocytic seminoma (SS) and a differentiated teratoma (TD). Furthermore, two small foci of seminoma were seen in the surrounding testicular tissue, several testicular tubuli contained carcinoma in situ (CIS). The diagnosis was based on the results obtained with various immunohistochemical markers: keratin, vimentin, desmin, LCA, CD3, CD20, CD45R, ferritin, PLAP, AFP. On the basis of the macroscopic and histopathological features, we propose the following etiology: CIS progressed in an earlier phase to the (larger) TD and later to the (smaller) classical seminoma; likewise, in an earlier phase, SS developed from a still unknown precursor stage. Our case of a mixed tumor as well as other cases reported in the last years do not allow the explanation of a differing etiology for SS. On the contrary, it may be presumed that the origins of seminoma and teratoma on the one hand and SS on the other hand are less divergent than hitherto thought.
authors.affiliation: Institut für Pathologie, Krankenhäuser des Märkischen Kreises GmbH, Lüdenscheid, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Böhm
authors.forename: P H
authors.initials: PH
authors.lastname: Walz
authors.forename: K H
authors.initials: KH
authors.lastname: Tan
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D018239:Seminoma / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D013724:Teratoma / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Eine Kombination von spermatozytischem und klassischem Seminom, reifem Teratom und Carcinoma in situ des Hodens. Versuch einer ätiologischen Zuordnung.