[Interaction of heparinized polymer materials with plasma proteins and thrombocytes].
The interaction of heparinized polymer materials with human plasma proteins (serum albumin (SA), fibrinogen (F), antithrombin III (AT-III)) and platelets was studied. The level of SA and F adsorption irreversibility was demonstrated to depend on the mode of heparin immobilization. There was a negative correlation between the parameters of protein adsorption and the level of adsorbed AT-III. The relationship of the count of platelets adhered to the surface of heparinized polymer materials, to the time of contact was shown to be extreme. There was a correlation between the count of adhesive platelets and the parameters of plasma protein and AT-III adsorption. Based on experimental evidence, a scheme was proposed, which describes the impact of protein adsorption processes on the anticoagulative activity of surface-bound heparin, It is concluded that AT-III plays a particular role as the major component of the adsorption layer that is responsible for the nature of interactions of polymer materials with blood at the protein and cellular levels.
Nemets
E A
EA
Sevastíanov
V I
VI
D000327:Adsorption; D000990:Antithrombin III / Q000378:metabolism*; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006493:Heparin / Q000493:pharmacokinetics*; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D011108:Polymers / Q000493:pharmacokinetics*; D012709:Serum Albumin / Q000378:metabolism*
D011108:Polymers; D012709:Serum Albumin; D000990:Antithrombin III; D005340:Fibrinogen; D006493:Heparin
Vzaimodeĭstvie geparinizirovannykh polimernykh materialov s belkami plazmy krovi i trombotsitami.