[Köln hemoglobinopathy: 3 patients in one Russian family].
A rare disease with autosomal dominant inheritance was diagnosed in mother, her son and daughter. The condition was due to unstable hemoglobin Köln in 10% quantity. Clinical symptoms manifested most dramatically in a son, moderately in a daughter and slightly in a mother who had undergone splenectomy. All the hemolytic rises were provoked by antipyretics or, in occasional cases, by respiratory viral infections running with hyperthermia. To alleviate the symptoms, the son is scheduled for splenectomy.
Smetanina
N S
NS
Zhestkova
N M
NM
Molchanova
T P
TP
Tokarev
Iu N
IuN
D000328:Adult; D000746:Anemia, Hemolytic, Congenital Nonspherocytic / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D002648:Child; D005260:Female; D006453:Hemoglobinopathies / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D008297:Male; D012426:Russia
D006455:Hemoglobins, Abnormal; C034409:hemoglobin Koln
Gemoglobinopatiia Köln: troe bol'nykh v odnoĭ russkoĭ sem'e.