title: The role of the octanoic fatty acid in the pathogenesis of the metabolic alkalosis in experimental liver failure.
abstract: Octanoate was found to stimulate the muscle proteins catabolism in rats with portacaval anastomosis thus increasing the amounts of 3-methylhistidine, creatinine, ammonium and urea in the excreted urine. The intensive decomposition of the endogenous proteins also produced great amounts of HCO3- whose levels increased in both the urine and blood. It is suggested that in hepatic insufficiency octanoate causes metabolic acidosis through: a) more intensive catabolism of the muscle proteins whose decomposition results in greater amounts of HCO3-, b) metabolization of octanoate to HCO3-, and c) inhibition of the ornithine cycle.
authors.affiliation: Department of Pathophysiology, University of Medicine, Plovdiv, Bulgaria.
authors.forename: D
authors.initials: D
authors.lastname: Mitkov
mesh_terms: D000471:Alkalosis / Q000209:etiology* / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002210:Caprylates / Q000378:metabolism / Q000633:toxicity*; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000378:metabolism; D017093:Liver Failure / Q000150:complications* / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism; D051381:Rats
chemical_list: D001639:Bicarbonates; D002210:Caprylates; D009124:Muscle Proteins; C031492:octanoic acid