Negative 123-meta-iodobenzyl-guanidine imaging in Ewing's sarcoma of bone.
The role of radiolabeled meta-iodobenzyl-guanidine (mIBG) is established in the detection and the staging of neuroblastoma. We designed a study of mIBG scanning for patients with Ewing's sarcoma, a tumor for which a neuroectodermic origin has been proposed. We explored 15 children with round cell sarcoma of bone by a whole body scan carried out 24 hours after injection of 123-I mIBG. No patient demonstrated significant uptake either at the site of the primary or at the sites of metastases. These results suggest that despite its neural histogenesis Ewing's sarcoma is a member of the nonneuroblastoma neural crest tumors, which does not produce or store adrenergic metabolites.
Oberlin
O
O
Department of Pediatrics, Institut Gustave Roussy, Villejuif, France.
Lumbroso
J
J
Terrier
P
P
Hartmann
O
O
Lemerle
J
J
Parmentier
C
C
D019797:3-Iodobenzylguanidine; D000077:Acetabulum; D000293:Adolescent; D001859:Bone Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism; D008297:Male; D017599:Neuroectodermal Tumors / Q000145:classification / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing / Q000145:classification* / Q000000981:diagnostic imaging* / Q000378:metabolism; D013565:Sympatholytics / Q000378:metabolism; D013977:Tibia
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013565:Sympatholytics; D019797:3-Iodobenzylguanidine