Unresponsiveness of antidonor cytotoxic T cells in a long-term stable renal transplant recipient.
The antidonor immune response was examined in a one haplotype-mismatched renal transplant recipient with an allograft that had been well-functioning for more than 10 years. Although the relative response of the mixed lymphocyte reaction (MLR) was (45.8)% and the MLR responder cells stimulated by donor cells produced measurable amounts of interleukin-2 (IL-2) (11.6 U/ml), the cytotoxic T lymphocytes (CTL) could not be generated against donor cells, even with exogenous IL-2. These results indicate that antidonor CTL precursors were either deleted or inactivated in this recipient.
Fujiwara
T
T
Department of Transplantation Surgery, Center for Adult Diseases, Kurashiki, Japan.
Sakagami
K
K
Saito
S
S
Uda
M
M
Orita
K
K
D000328:Adult; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D011184:Postoperative Period; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology*; D013997:Time Factors; D014019:Tissue Donors
D000941:Antigens; D007376:Interleukin-2