title: [Experimental exposure to carbon monoxide in rats (II)--blood volume of organs obtained by calculations from amounts of carbon monoxide in organ tissues and in blood].
abstract: We have found a correlation between the degree of carboxyhemoglobin saturation and the amount of carbon monoxide (CO) in the organ tissues of rats. This essay is titled "Experimental exposure to carbon monoxide in rats (I)". In this report, the blood volumes in organs were calculated from the amount of CO in the blood and in the organ tissues of the same rat. The obtained blood volume (microliter/g of organ tissues) were as follows: spleen 0.196 +/- 0.0222 liver 0.186 +/- 0.0576, lung 0.166 +/- 0.0156, myocardium 0.095 +/- 0.0319, kidney 0.094 +/- 0.0267 and encephalon 0.033 +/- 0.0183. Except for the 10% COHb experimental group, it has become clear that the blood volume in the spleen and in the kidney did not change much despite the variation of degree of carboxyhemoglobin saturation. In order to diagnose the cause of death of a burned cadaver in which the heart did not contain the liquid blood, values of CO amounts should be determined from those in the spleen or the kidney.
authors.affiliation: Department of Legal Medicine, School of Medicine, Ehime University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shinomiya
authors.forename: C
authors.initials: C
authors.lastname: Orimoto
authors.forename: T
authors.initials: T
authors.lastname: Shinomiya
mesh_terms: D000818:Animals; D001810:Blood Volume; D002248:Carbon Monoxide / Q000097:blood / Q000493:pharmacokinetics*; D002249:Carbon Monoxide Poisoning / Q000378:metabolism / Q000503:physiopathology*; D002263:Carboxyhemoglobin / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D002248:Carbon Monoxide; D002263:Carboxyhemoglobin