Anti inflammatory, analgesic, antiproteolytic and ulcerogenic activities of some new 1-[3-(aryloxy)-propyl]-diamines.
The anti-inflammatory activity of some new 1-[3-(aryloxy)-propyl] diamines using the carrageenin rat paw edema test has been investigated. Arthritis induced by Freund's adjuvant was also used. Writhing induced by acetic acid in rats was used to evaluate analgesic activity. The irritative and ulcerogenic action on the rat gastric mucosa was examined after oral administration. Antiproteolytic activity has also been studied. The experimental results are discussed from the point of view of structure activity relationships.
Dimitra
H L
HL
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005029:Ethylenediamines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D006614:Hindlimb; D066298:In Vitro Techniques; D008297:Male; D011412:Propanolamines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D013276:Stomach Ulcer / Q000139:chemically induced; D014357:Trypsin / Q000378:metabolism
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005029:Ethylenediamines; D011412:Propanolamines; D011506:Proteins; D002351:Carrageenan; D014357:Trypsin