In vitro study of the effect of photodynamic therapy on pituitary adenomas.
Photodynamic therapy (PDT) has been employed in the management of recurrent cerebral gliomas, but its activity against pituitary adenomas has not been specifically studied. An in vitro study of the effects of PDT against a variety of pituitary adenomas was conducted. It was found that PDT using haematoporphyrin derivative as a photosensitizer showed dose dependent activity against a variety of pituitary adenomas. The activity of PDT against pituitary adenomas should be investigated further and may hopefully provide a useful form of adjuvant therapy for preventing recurrence of micro-invasive pituitary adenomas or dealing with established recurrence after surgery and radiotherapy.
Marks
P V
PV
Department of Neurosurgery, General Infirmary at Leeds, UK.
Buxton
T
T
Furneaux
C E
CE
D000236:Adenoma / Q000188:drug therapy* / Q000473:pathology; D000238:Adenoma, Chromophobe / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects / Q000473:pathology; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015175:Prolactinoma / Q000188:drug therapy / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology
D013006:Growth Hormone