title: Parvovirus B19-associated haemophagocytic syndrome with prominent neutrophilia.
abstract: We describe a patient with both haemophagocytic syndrome and acute myocarditis probably associated with parvovirus B19 infection. The patient had a marked neutrophilia instead of neutropenia more usually observed in virus-associated haemophagocytic syndrome (VAHS). Endogenous serum concentrations of macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), and tumour necrosis factor-alpha (TNF-alpha) were higher than normal, suggesting that these cytokines may be involved in the genesis of the observed syndrome.
authors.affiliation: Division of Clinical Haematology/Immunology, Kumamoto City Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: A
authors.initials: A
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Miyayama
mesh_terms: D000208:Acute Disease; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007964:Leukocytosis / Q000382:microbiology*; D009205:Myocarditis / Q000382:microbiology*; D009504:Neutrophils / Q000473:pathology*