Structure of a pineal gland-derived antigonadotropic decapeptide.
An antigonadotropic decapeptide was extracted from bovine pineal glands, purified by ultrafiltration and Sephadex G-25 gel-filtration chromatography and isolated by serial semi-preparative high performance liquid chromatography. Its primary structure was determined by automated amino acid and microsequence analyses. A synthetic analog of the decapeptide, prepared by solid state methods, was observed to reduce circulating levels of luteinizing hormone and prolactin after intra-atrial injection in male rats.
Benson
B
B
Department of Anatomy, University of Arizona, Tucson.
Ebels
I
I
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D006062:Gonadotropins / Q000037:antagonists & inhibitors*; D008297:Male; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010870:Pineal Gland / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D006062:Gonadotropins; D009842:Oligopeptides