[Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc].
Besides the known components kadsurenone, futoquinol and futoxide, three anti-platelet activating factor principles have been found from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng. They were separated and identified as galgravin, galbelgin and veraguensin on the basis of HPLC and spectral analysis. The natural existence of these three anti-PAF constituents in haifengteng is reported for the first time.
Chen
Z N
ZN
Department of Chemistry, Shanghai Second Medical University.
Yu
P Z
PZ
Xu
P J
PJ
D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D017705:Lignans; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*
D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D010972:Platelet Activating Factor; C084077:galgravin