[Induction of hematologic remission in a patient with acute promyelocytic leukemia through the therapeutic use of trans-retinoic acid].
A case of 62-year-old female with acute promyelocytic leukemia is presented, in whom in poor general condition, and with symptoms of severe haemorrhagic diathesis and biochemical signs of coagulopathy a treatment with trans-retinoic acid was induced. After three weeks of treatment with t-RA complete hematological and clinical remission was achieved, without bone marrow aplasia, worsening of hemostatic parameters, or necessity of protective or therapeutic antibiotics administration typical of conventional chemotherapy. Apart from skin allergization and increase of transaminases other side effects of the t-RA treatment were not observed.
Skotnicki
A B
AB
Kliniki Hematologii Collegium Medicum Uniwersytetu Jagiellońskiego, Krakowie.
Stoch
A
A
Sacha
T
T
Nowak
W S
WS
D001778:Blood Coagulation Disorders / Q000188:drug therapy; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D012074:Remission Induction; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
D014212:Tretinoin
Indukcja remisji hematologicznej u chorej z ostra białaczka promielocytowa przy pomocy kwasu trans-retinowego.