[Cytogenetic activity of testosterone propionate and methyltestosterone in a culture of lymphocytes of healthy women and women suffering from hyperandrogenism].
To discover the effects of various concentrations of androgenic preparations on lymphocyte cultures from healthy women (group 1) and of women with hyperandrogenism (group 2), a total of 6792 metaphases were examined after peripheral blood lymphocyte culturing after Hangerford. The data indicated a relatively high incidence of aberrant metaphases, total number of ruptures and paired ruptures in the second group, a higher cytogenetic activity of testosterone propionate in both groups, and a higher cytogenetic activity of androgenic hormones in the second group. Bearing in mind a similar, if not higher, activity of endogenic testosterone in a female organism, we must admit a high probability of genetic system involvement in women suffering from hyperandrogenism.
Dolian
G G
GG
Martirosian
A A
AA
D000328:Adult; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D008214:Lymphocytes / Q000187:drug effects*; D008677:Metaphase / Q000187:drug effects; D008777:Methyltestosterone / Q000633:toxicity*; D012016:Reference Values; D013739:Testosterone / Q000633:toxicity*
D013739:Testosterone; D008777:Methyltestosterone
Tsitogeneticheskaia aktivnost' testosteron-propionata i metiltestosterona v kul'tury limfotsitov zdorovykh zhenshchin i zhenshchin, stradaiushchikh hiperandrogenieĭ.