Atrial natriuretic polypeptide (ANP)-immunoreactivity and specific atrial granules in cardiac myocytes of stroke-prone spontaneously hypertensive rat (SHRSP).
The distribution of atrial natriuretic polypeptide (ANP) and atrial specific granules in the myocytes of the atria and ventricles of an experimental animal model, stroke-prone spontaneously hypertensive rats (SHRSP) and a control, Wistar Kyoto rats (WKY), was examined using immunocytochemical and electron microscopic techniques. In the atria of both SHRSP and WKY, ANP-immunoreactivity was recognized in the perinuclear regions of essentially all cardiac myocytes. In the ventricles of WKY, ANP-immunoreactivity was hardly seen except for the impulse-conducting system. However, in the ventricles of SHRSP, almost all cardiac myocytes possessed immunoreaction products which were scattered evenly throughout the cytoplasm; this distribution pattern differed from that of the atrial wall of this strain.
Nishimura
T
T
Department of Anatomy, Shiga University of Medical Science, Otsu, Japan.
Mizukawa
K
K
Nakao
K
K
Yamada
H
H
Kinoshita
M
M
Ochi
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000737:chemistry*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006325:Heart Atria; D006352:Heart Ventricles; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000737:chemistry* / Q000166:cytology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D009320:Atrial Natriuretic Factor