Immunocytochemical localization of copper-zinc superoxide dismutase in mouse olfactory mucosa.
Copper-zinc superoxide dismutase (Cu-Zn SOD) has been localized in mouse nasal mucosa. Immunocytochemical staining using polyclonal antibody against Cu-Zn SOD revealed endogenous Cu-Zn SOD in sustentacular cells in the olfactory area, and in ciliated epithelial cells in the respiratory area of the olfactory mucosa. Since these cells are located in the superficial portion of the olfactory mucosa, Cu-Zn SOD may serve as an intracellular antioxidant.
Sakai
M
M
Department of Anatomy, Fujita Health University School of Medicine, Toyoake, Japan.
Takeuchi
M
M
Umemura
Y
Y
Ueda
H
H
Ohmori
T
T
Ashihara
M
M
Nagatsu
I
I
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification; D002923:Cilia; D004847:Epithelial Cells; D007150:Immunohistochemistry; D051379:Mice; D009297:Nasal Mucosa / Q000166:cytology / Q000201:enzymology*; D009832:Olfactory Nerve / Q000166:cytology / Q000276:immunology*; D012903:Smell / Q000502:physiology*; D013482:Superoxide Dismutase / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*
D000975:Antioxidants; D013482:Superoxide Dismutase