title: The effect of uvulonodular lesions on horizontal optokinetic nystagmus and optokinetic after-nystagmus in cats.
abstract: The effect of uvulonodular lesions on horizontal optokinetic nystagmus (OKN) and optokinetic after-nystagmus (OKAN) was investigated in alert cats. A lesion in each of 6 cats was made by suction-ablation under anesthesia. In the 3 cats with only a uvular lesion, both the initial slow phase velocity and the time constant of OKAN were unchanged. In the remaining 3 cats whose lesions included the nodulus as well as the uvula, the time constant of OKAN was markedly prolonged, but the initial slow phase velocity of OKAN was not affected. The postoperative average time constant of OKAN increased from the normal value of 9 s to about 40 s. In contrast, OKN parameters (the steady-state velocity and the rising time constant) were not affected by uvular or uvulonodular lesions. These results strongly suggest that the nodulus is involved in the velocity storage mechanism and might control the discharge characteristics of the velocity storage integrator.
authors.affiliation: Department of Otolaryngology, Yamagata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Ikarashi
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology; D002415:Cats; D002526:Cerebellar Diseases / Q000473:pathology / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology; D004585:Electrooculography; D005133:Eye Movements / Q000502:physiology; D017120:Nystagmus, Optokinetic / Q000502:physiology*; D009759:Nystagmus, Pathologic / Q000503:physiopathology*; D013997:Time Factors; D014726:Vestibular Nuclei / Q000473:pathology / Q000503:physiopathology*; D014795:Visual Pathways / Q000473:pathology / Q000503:physiopathology