Successful mass vaccination against hepatitis B virus in a hyperendemic area in Italy.
A pilot model of vaccination against hepatitis B virus suitable for mass vaccination was performed from 1983-1989 in the hyperendemic area of Afragola, a town of 60,000 inhabitants near Naples. In this area of high prevalence of HBsAg carriers, a consistent reduction in the incidence of hepatitis B virus infections as well as chronic related liver complications was observed.
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Italian Institute for Prevention of Liver Diseases, F. De Ritis Collaborating Center of W.H.O., Napoli.
D000293:Adolescent; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology; D008137:Longitudinal Studies; D008875:Middle Aged; D010865:Pilot Projects; D014505:Urban Population; D014611:Vaccination
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines