Intracranial self-stimulation and locomotor traces as indicators for evaluating the homopantothenic acid.
Our paper compares the effect of homopantothenic acid (HOPA) and haloperidol (HAL), i.e., representative neuroleptics, on intracranial self-stimulation (ICSS) and locomotor activity. These experiments showed that HOPA inhibited abnormal hyperactivity induced by methamphetamine (MAP) but did not inhibit ICSS which is considered with respect to physiological motivations. On the other hand, haloperidol (HAL) markedly inhibited both ICSS and abnormal hyperactivity induced by MAP. We propose that combined ICSS and locomotor traces can be chosen as indicators for evaluation and developing the new neuroleptics.
Takigawa
M
M
Health Service Center, Kagoshima University, Japan.
Ueyama
K
K
Fukuzako
H
H
Maeda
H
H
Matsumoto
K
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006220:Haloperidol / Q000494:pharmacology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009949:Orientation / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012653:Self Stimulation / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D006220:Haloperidol