Meningeal meningiomatosis in a child: case report.
We report a child with multifocal meningeal lesions demonstrating mixed meningiomatous histologic features. This lesion appears to have evolved over seven years, starting with a brief episode of garbled speech, nausea, and headache at 4.5 years of age. The child was then asymptomatic until 9 when she presented with bilateral leg weakness, in addition to her prior presenting symptoms and communicating hydrocephalus. Meningeal biopsies of two lesions were performed 18 months later. Immunohistochemistry and electron microscopy were needed to substantiate the histologic diagnosis. Radiation therapy to the craniospinal axis and corticosteroids were of some benefit, but more aggressive therapeutic modalities became necessary. The nosology of this lesion is discussed.
Avellino
A M
AM
Department of Pathology (Division of Neuropathology), Columbia Presbyterian Hospital, College of Physicians and Surgeons, New York, NY.
Hair
L S
LS
Symmans
W F
WF
Gold
A P
AP
Carmel
P
P
Powers
J M
JM
D000293:Adolescent; D001706:Biopsy; D002552:Cerebral Ventricles / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008578:Meninges / Q000473:pathology; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008854:Microscopy, Electron; D009460:Neurologic Examination; D014057:Tomography, X-Ray Computed