Primary central white matter degeneration in old dogs.
Degeneration of the central white matter is described in old dogs. The presence of ubiquitin-immunoreactive free granules and intracytoplasmic globules in glial cells and macrophages, together with galacerebroside-immunoreactive precipitates and lipofusion storage, point to the likelihood of a primary myelin degeneration with deposits of non-degraded ubiquitin-protein conjugates and complex galactolipids.
Ferrer
I
I
Unit of Neuropathology, Hospital Principes de Espana, University of Barcelona, Spain.
Pumarola
M
M
Rivera
R
R
Zújar
M J
MJ
Cruz-Sánchez
F
F
Vidal
A
A
D000375:Aging / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D004285:Dogs; D005260:Female; D005699:Galactosylceramides / Q000276:immunology / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology; D007150:Immunohistochemistry; D008062:Lipofuscin / Q000378:metabolism; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D008578:Meninges / Q000473:pathology; D016253:Microscopy, Immunoelectron; D009410:Nerve Degeneration / Q000502:physiology; D009457:Neuroglia / Q000648:ultrastructure
D005699:Galactosylceramides; D008062:Lipofuscin