[Levamisole in children with frequently recurring idiopathic nephrotic syndrome].
10 children (8 boys and 2 girls) with frequently relapsing idiopathic nephrotic syndrome were treated with levamisole (5 mg/kg weekly). In 6 children with steroid dependent nephrotic syndrome a marked reduction in steroids by 62% to 75% was possible. Severe, transient neutropenia was observed in one patient. Levamisole failed to influence the disease course positively in 3 patients with relapses associated with intercurrent illness. It is concluded that levamisole may favourably influence steroid dependence in children with frequently relapsing idiopathic nephrotic syndrome.
Meregalli
P
P
Abteilung für Nephrologie, Medizinischen Universitäts-Kinderklinik Bern.
Bianchetti
M G
MG
Imoberdorf
G
G
Lütschg
J
J
Reymond
D
D
Oetliker
O H
OH
D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012008:Recurrence
D007978:Levamisole; D003520:Cyclophosphamide
Levamisol bei Kindern mit häufig rezidivierendem idiopathischem nephrotischem Syndrom.