title: [The immunomodulating effect of vilozen and splenin in the treatment of patients with acute and chronic toxic-allergic hepatitis].
abstract: 65 patients with acute hepatitis and 116 patients with chronic hepatitis of toxico-allergic nature were examined. 20 patients with acute hepatitis and 40 patients with chronic form of the disease were prescribed in addition to conventional treatment 2-4 ml i.m. of splenin daily, 20 mg of vilosen daily in 3-4 divided doses in the form of 1% solution intranasally and the same quantity--sublingually. The drugs were administered for 10-15 days. Co-administration of splenin and vilosen was established to hasten normalization of clinical indices and immune homeostasis restitution thus advocating the use of the drugs as a part of therapeutic complex in the treatment of acute and chronic toxico-allergic hepatitis.
authors.forename: V M
authors.initials: VM
authors.lastname: Frolov
authors.forename: N A
authors.initials: NA
authors.lastname: Peresadin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Vysotskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Tishchenko
authors.forename: L L
authors.initials: LL
authors.lastname: Pinskiĭ
mesh_terms: D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006505:Hepatitis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D051381:Rats; D013946:Thymopoietins / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D013946:Thymopoietins; D013949:Thymus Extracts; C059606:iilozen; C032841:thymopoietin III
vernacular_title: Immunomoduliruiushchiĭ èffekt vilozena i splenina pri lechenii bol'nykh ostrym i khronicheskim toksiko-allergicheskim gepatitom.