[The long-term use of antihypoxants in myocardial infarct in rats: their effect on the hemodynamics and contractile function of the heart].
In the experiments in rats with myocardial infarction induced by left coronary occlusion, effects of antihypoxants were studied during their long-term intraperitoneal injection (daily once during 21 days) on hemodynamics and myocardial contractility. Sodium oxybutyrate, 200 mg/kg, piracetam, 400 mg/kg, and glyo-6, 100 mg/kg, were shown to exert no significant effects on cardiac contractility at rest, however during exercise they normalized aortic blood flow acceleration. The antihypoxants increased the survival of rats with myocardial infarction.
Tsorin
I B
IB
Kazanova
G V
GV
Chichkanov
G G
GG
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D010889:Piracetam / Q000627:therapeutic use; D011736:Pyridoxine / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use; D013997:Time Factors
C001310:pyridoxilate; D012978:Sodium Oxybate; D011736:Pyridoxine; D010889:Piracetam
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