[Effect of physostigmine on acetylcholine and monoamine metabolites in rat frontal cortex with lesions of the nucleus basalis of Meynert].
Acetylcholine (ACh) and monamine (MA) metabolites were collected from the frontal cortex of free moving rats, using a microdialysis technique. In rats subjected to bilateral ibotenic acid lesioning of the nucleus basalis of Meynert (nbM), ACh release was markedly decreased, while DOPAC, HVA and 5-HIAA were not affected. Physostigmine (0.3 mg/kg, IP) increased ACh concentration in the brain dialysate, and the rate of ACh increase was lower in nbM-lesioned rats than that in unoperated rats. Physostigmine also increased the concentration of MA metabolites in both nbM-lesioned and unoperated rats equally. The results indicate that there may be some interaction between non nbM-originated cholinergic systems and monoaminergic systems in the frontal cortex.
Kato
H
H
Department of Neurology, Tokai University School of Medicine.
Aikawa
H
H
Yamamoto
M
M
Shigeta
S
S
Shinohara
Y
Y
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism* / Q000502:physiology; D005625:Frontal Lobe / Q000378:metabolism*; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013377:Substantia Innominata / Q000502:physiology*
D015306:Biogenic Monoamines; D010830:Physostigmine; D000109:Acetylcholine