Lymphocyte responses to viral antigens and phytohaemagglutinin in persistently viraemic sheep and lambs experimentally infected with Border disease virus.
Lymphocytes obtained from lambs 5 to 21 days after experimental infection with Border disease virus (BDV) showed significant blastogenic responses to live or inactivated BDV. Live virus stimulated significantly higher lymphocyte transformation (LT) responses than inactivated virus. Lymphocytes obtained from uninfected control and persistently infected lambs had no significant response to live or inactivated antigen. Lymphocyte responses to phytohaemagglutinin were significantly higher in control lambs than in experimentally infected lambs in samples obtained 5 to 10 days post-inoculation.
Hussin
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AA
University of Liverpool, Department of Veterinary Pathology, Neston, Wirral, UK.
Woldehiwet
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Z
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D001882:Border Disease / Q000276:immunology*; D018083:Border disease virus / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010835:Phytohemagglutinins / Q000276:immunology*; D012756:Sheep; D014766:Viremia / Q000276:immunology*
D000956:Antigens, Viral; D010835:Phytohemagglutinins