title: The primary structure of rat ribosomal protein L15.
abstract: The amino acid sequence of the rat 60S ribosomal subunit protein L15 was deduced from the sequence of nucleotides in two recombinant cDNAs. Ribosomal protein L15 has 203 amino acids, the NH2-terminal methionine is removed after translation of the mRNA, and has a molecular weight of 24,000. Hybridization of the cDNA to digests of nuclear DNA suggests that there are 13 to 15 copies of the L15 gene. The mRNA for the protein is about 850 nucleotides in length. Rat L15 is related to ribosomal proteins from other eukaryotes. Rat L15 has the hexapeptide, TYKFFE, that also occurs in the amyloidogenic glycoprotein A4 which is associated with Alzheimer's disease and Down's Syndrome.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
authors.forename: Y L
authors.initials: YL
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Olvera
authors.forename: I G
authors.initials: IG
authors.lastname: Wool
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D015870:Gene Expression; D005796:Genes; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D012269:Ribosomal Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D012269:Ribosomal Proteins; C043649:ribosomal protein L15