Myoelectric activity during small bowel allograft rejection.
The effect of rejection on myoelectric activity of an orthotopically transplanted small intestinal segment (group I, N = 14) was studied. Electrodes were placed on grafts and recipient small bowel. Isografts (group II, N = 5) and native bowel (group III, N = 5) served as controls. The first morphological signs of rejection were seen on day 6 and steadily progressed until day 11, when the cellular infiltrate involved all layers of the bowel wall. Slow-wave frequencies remained unchanged throughout the observation period. No difference was detectable between grafts (group I: 31.9 +/- 1.65; group II: 31.36 +/- 0.7) and native bowel after transection (group I: 32.16 +/- 1.78; group II: 31.50 +/- 1.01), which was different (P = 0.0001) from intact bowel of group III animals (38.4 +/- 0.81). Irregular MMCs were detectable in grafts from day 5 on and replaced after food intake by random spiking activities. At day 8, spiking activities disappeared in allografts, which showed a still preserved mucosal architecture, while slow-wave activities continued. These findings demonstrate that intestinal allografts during rejection develop paralysis before mucosal destruction is established, which might be of clinical relevance.
Pernthaler
H
H
Department of Transplant Surgery, University Hospital, Innsbruck, Austria.
Kreczy
A
A
Plattner
R
R
Pfurtscheller
G
G
Saltuari
L
L
Schmid
T
T
Ofner
D
D
Klima
G
G
Margreiter
R
R
D000200:Action Potentials; D000818:Animals; D004576:Electromyography; D006084:Graft Rejection / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology* / Q000637:transplantation*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous