Prewatering and haloperidol have similar effects on rats' response rate and duration.
Haloperidol (0.1 mg/kg) and 5-min prewatering were given to 12 rats on three occasions each to determine effects on fixed ratio 15 (FR 15) responding for water. Compared to baseline, both treatments significantly reduced rate (prewatering slightly more) and both significantly increased duration. Though similar, drug and prewatering effects showed enough differences to suggest that there are both anhedonic and motoric deficit components to haloperidol's effects on rats' lever-pressing behavior for water.
Jackson
D E
DE
Indiana University Northwest, Gary 46408.
Bowen
S E
SE
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D051381:Rats; D012055:Reinforcement Schedule
D006220:Haloperidol