title: Tumor cytotoxicity and production of interleukin-1 and tumor necrosis factor from blood monocytes of cervical carcinoma patients.
abstract: To assess the functional integrity of monocytes in patients with cervical carcinoma, cytotoxic potential of peripheral blood monocytes and their ability to secrete interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) after activation with different stimulating agents were studied. Comparable levels of monocyte-mediated cytotoxicity were observed in healthy donors and patients. The production of IL-1 and TNF-alpha by monocytes of healthy donors and patients was similar indicating no defect in monocyte functions in these patients.
authors.affiliation: Immunology Division, Tata Memorial Hospital, Tata Memorial Centre, Parel, Bombay, India.
authors.forename: J J
authors.initials: JJ
authors.lastname: Nadkarni
authors.forename: A K
authors.initials: AK
authors.lastname: De
authors.forename: K J
authors.initials: KJ
authors.lastname: Jhaver
authors.forename: M R
authors.initials: MR
authors.lastname: Kamat
mesh_terms: D000328:Adult; D000368:Aged; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha