title: [Locally advanced cancer of the breast (LACB) and identification of estrogen receptors with monoclonal antibodies].
abstract: The effects of therapy in locally advanced breast cancer submitted to combined conventional telecobalt therapy plus chemotherapy with cyclophosphamide and 5-fluorouracil were studied in 49 patients. Associated to radical mastectomy in operable cases. Local tumor control was achieved in 86.7%. There were no local recurrences in those submitted to surgery but they reached 21.7% in inoperable patients who received only radiation therapy and chemotherapy. The median follow-up time for dead patients was 29.5 months and for living patients 79.3 months. The index of complete responses was 24.5% and the median disease free interval was 22.9 months. The overall survival rate, between three and five years, was 32.7%. Estrogen receptors were identified by using immunohistochemical assay ER-ICA and monoclonal antibody H222-SP gamma, Abbott. There were no differences in the complete response index, disease free interval and survival rates, among ER-positive and ER-negative patients, explained by the far advanced stage of the disease. ER-positivity was significantly correlated with histological features of the tumors: cell differentiation, presence of elastosis, absence of lymphocytic infiltration and absence of tumor necrosis.
authors.affiliation: Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu (UNESP), SP.
authors.forename: L A
authors.initials: LA
authors.lastname: de Luca
authors.forename: F C
authors.initials: FC
authors.lastname: Schmitt
authors.forename: P
authors.initials: P
authors.lastname: Traiman
authors.forename: B
authors.initials: B
authors.lastname: Oliveira Júnior
authors.forename: L M
authors.initials: LM
authors.lastname: de Andrade
authors.forename: M V
authors.initials: MV
authors.lastname: Rudge
authors.forename: M T
authors.initials: MT
authors.lastname: Lunardi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D012189:Retrospective Studies
chemical_list: D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen
vernacular_title: Considerações sobre o câncer localmente avançado de mama (CLAM) acrescidas de identificação dos receptores de estrogênios usando anticorpos monoclonais.