Evidence of measles virus RNA in otosclerotic tissue.
By use of the very sensitive polymerase chain reaction technique, evidence is given that otosclerosis is a measles-virus-associated disease of the otic capsule. These results support recent observations which demonstrated the expression of measles antigen within active otosclerotic foci by immunohistochemical methods. Thus it is hypothesized that the viral infection acts as at least one pathogenetic factor during the development of this obscure, locally restricted inflammatory bone disease.
Niedermeyer
H
H
Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University, Munich, FRG.
Arnold
W
W
Neubert
W J
WJ
Höfler
H
H
D015139:Blotting, Southern; D004427:Ear Diseases / Q000382:microbiology; D004432:Ear, Middle / Q000382:microbiology*; D016679:Genome, Viral; D006801:Humans; D008459:Measles virus / Q000235:genetics*; D010040:Otosclerosis / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis*; D012888:Skull Neoplasms / Q000382:microbiology; D013701:Temporal Bone / Q000382:microbiology; D014158:Transcription, Genetic
D012333:RNA, Messenger; D012367:RNA, Viral