Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury.
Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment. Such seizures are more likely in the elderly, in the presence of pre-existing neurological disease, and when theophylline is given with certain antibiotics and cimetidine. The mechanism of neuronal injury may be by the excessive release of endogenous excitotoxic glutamate.
O'Riordan
J I
JI
Department of Neurology, St Vincent's Hospital, Dublin, Ireland.
Hutchinson
J
J
FitzGerald
M X
MX
Hutchinson
M
M
D000293:Adolescent; D000368:Aged; D000647:Amnesia / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012640:Seizures / Q000139:chemically induced* / Q000523:psychology; D013577:Syndrome; D013806:Theophylline / Q000009:adverse effects*
D013806:Theophylline