title: Acetylation of core histones causes the unfolding of 30 nm chromatin fiber: analysis by agarose gel electrophoresis.
abstract: In the present work it was directly demonstrated that increased acetylation level of histones causes the decompactization of 30 nm chromatin fiber, as revealed by low-percentage agarose gel electrophoresis. In the light of obtained results the possible molecular mechanism of the decompactization of acetylated fiber is discussed.
authors.affiliation: Laboratory of Biochemistry, Russian Academy of Sciences, Moscow.
authors.forename: W A
authors.initials: WA
authors.lastname: Krajewski
authors.forename: V M
authors.initials: VM
authors.lastname: Panin
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000648:ultrastructure*; D004587:Electrophoresis, Agar Gel; D006657:Histones / Q000737:chemistry*; D008099:Liver / Q000737:chemistry / Q000648:ultrastructure; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009707:Nucleosomes; D011487:Protein Conformation; D051381:Rats
chemical_list: D002843:Chromatin; D006657:Histones; D009707:Nucleosomes