Synthesis of some 4-oxo-delta 2-thiazolin-2-ylhydrazones as potential antiprotozoal agents.
Several 4-oxo-delta 2-thiazolin-2-ylhydrazone derivatives 6 (6-1 - 6-19) derived from the cyclization reaction between the thiosemicarbazones 5 and homologous alpha-chloroacids were prepared. Only compound 6-2 was found to be active against Entamoeba histolytica and Trichomonas vaginalis.
Alves
A J
AJ
Departamento de Farmácia, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Leite
A C
AC
De Santana
D P
DP
Beltrao
T M
TM
Coelho
M R
MR
Gayral
P
P
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects
D000981:Antiprotozoal Agents; D006835:Hydrazones; D013844:Thiazoles; D008795:Metronidazole