title: Native valve endocarditis due to Candida parapsilosis: a late complication after bone marrow transplantation-related fungemia.
abstract: A case of Candida parapsilosis endocarditis observed 16 months after BMT is reported. The patient, a 35-year-old female with CML, suffered from Candida parapsilosis fungemia on day +22 after BMT. In spite of treatment with amphotericin B, fluconazole and catheter withdrawal, the same yeast was isolated > 1 year later from a vegetation on an old rheumatic mitral valve. Although the patient remained in complete cytogenetical and hematological remission, in vitro tests showed reduced phagocytic and chemotactic capacity of neutrophils and monocytes. This case stresses the need of prolonged therapy for patients with candidemia after BMT.
authors.affiliation: Department of Hematology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Cancelas
authors.forename: J
authors.initials: J
authors.lastname: Lopez
authors.forename: E
authors.initials: E
authors.lastname: Cabezudo
authors.forename: E
authors.initials: E
authors.lastname: Navas
authors.forename: J
authors.initials: J
authors.lastname: Garcia Laraña
authors.forename: M
authors.initials: M
authors.lastname: Jimenez Mena
authors.forename: P
authors.initials: P
authors.lastname: Diz
authors.forename: J
authors.initials: J
authors.lastname: Perez de Oteyza
authors.forename: L
authors.initials: L
authors.lastname: Villalon
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Sousa
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002175:Candida; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000209:etiology*; D004696:Endocarditis / Q000209:etiology* / Q000473:pathology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D016469:Fungemia / Q000150:complications* / Q000188:drug therapy / Q000209:etiology*; D006349:Heart Valve Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008943:Mitral Valve / Q000382:microbiology* / Q000473:pathology; D012008:Recurrence
chemical_list: D000666:Amphotericin B; D015725:Fluconazole