title: RSH/SLO (Smith-Lemli-Opitz) syndrome: designing a high cholesterol diet for the SLO syndrome.
abstract: A high cholesterol diet has been suggested to help prevent the poor reproductive outcomes found in heterozygote carriers of fetuses affected with the Smith-Lemli-Opitz (SLO) syndrome. The theory has also been presented that a high cholesterol medical food may enhance myelination of the central nervous system of the infant and prevent demyelination in the child and adult with SLO. Clinical studies are required to test this hypothesis and to determine the optimal composition of such medical foods. FDA requires proof of efficacy and controls nutrient composition, ingredients, and label claims of medical foods.
authors.affiliation: Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215.
authors.forename: P B
authors.initials: PB
authors.lastname: Acosta
mesh_terms: D000015:Abnormalities, Multiple / Q000178:diet therapy*; D000818:Animals; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D002784:Cholesterol / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000627:therapeutic use*; D003257:Consumer Product Safety; D003711:Demyelinating Diseases / Q000178:diet therapy*; D015195:Drug Design; D005260:Female; D005504:Food Analysis; D005527:Food, Fortified; D006801:Humans; D007223:Infant; D007225:Infant Food; D008607:Intellectual Disability / Q000178:diet therapy; D008052:Lipid Metabolism, Inborn Errors / Q000178:diet therapy*; D008431:Maternal-Fetal Exchange; D008831:Microcephaly; D009186:Myelin Sheath / Q000737:chemistry / Q000502:physiology; D009751:Nutritional Requirements; D010347:Patient Care Planning; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy; D013577:Syndrome; D014811:Vitamin E Deficiency / Q000503:physiopathology
chemical_list: D002791:Cholesterol, Dietary; D002784:Cholesterol