[Changes in the hemogram and in the laboratory parameters indicative of iron metabolism in mild viral infections].
OBJECTIVE
To assess the duration and intensity of the changes appearing in laboratory values related to iron utilisation during viral infection.


METHODS
With previous parental consent, 120 eutrophic infants received vaccination with attenuated measles virus or a combination of measles, mumps and rubella viruses as a model of mild viral infection. A number of laboratory tests were performed on day 0 and in two later occasions (4-21, 9-14 or 9-30); these included blood cell counts, ESR, serum iron, total iron binding capacity, transferrin saturation index, free erythrocytic protoporphyrin, serum ferritin, intra-erythrocytic ferritin, direct anti-human globulin test and C-reactive protein. The statistical analyses were done in accordance with ANOVA, Student's t test, Wilcoxon, Kruskall - Wallis, Mann-Whitney and Fisher methods.


RESULTS
A significant haemoglobin drop was seen on days 9 and 14 post-vaccination. This descent was > 10 g/L in 8.2% of the cases, and > or = 6 g/L in 19.6%. Serum iron and transferrin saturation decreased significantly, whereas mean corpuscular volume, free erythrocyte protoporphyrin and serum ferritin were significantly increased. All these but protoporphyrin recovered by day 30. Subjects with normal iron metabolism figures on day 0 and those whose thermal variations were above 38 degrees C had greater changes in the figures related to iron metabolism.


CONCLUSIONS
The evaluation of iron metabolism is not reliable if the patient has suffered from infection, although a mild viral one, in the three weeks prior to the study.
Olivares
M
M
Unidad de Hematología, Universidad de Chile, Santiago.
Walter
T
T
Llaguno
S
S
Osorio
M
M
Chadud
P
P
Velozo
L
L
D000208:Acute Disease; D000747:Anemia, Hypochromic / Q000209:etiology*; D001772:Blood Cell Count; D002097:C-Reactive Protein / Q000032:analysis; D003298:Coombs Test; D004338:Drug Combinations; D004909:Erythrocyte Indices; D005293:Ferritins / Q000097:blood; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood; D007501:Iron / Q000097:blood*; D008458:Measles Vaccine / Q000009:adverse effects*; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000009:adverse effects*; D011524:Protoporphyrins / Q000097:blood; D012411:Rubella Vaccine / Q000009:adverse effects*; D014168:Transferrin / Q000032:analysis; D014613:Vaccines, Attenuated
D004338:Drug Combinations; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D011524:Protoporphyrins; D012411:Rubella Vaccine; D014168:Transferrin; D014613:Vaccines, Attenuated; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron
Modificaciones del hemograma y de los parámetros de laboratorio indicadores del metabolismo de hierro en infecciones virales leves.