Differences in u-PA and t-PA increase during acute exercise: relation with exercise parameters.
Plasma levels of urokinase-type (u-PA Ag) and tissue-type (t-PA Ag) plasminogen activator are both enhanced during physical exercise. Whether, the extent of the increase and the post-exercise clearance rate of the two activators are comparable is not known. We studied the changes in u-PA Ag, t-PA Ag and t-PA activity during a standardized exercise test comprising submaximal and maximal exercise intensity. During submaximal (recreational) exercise, increases in u-PA are mainly due to changes in plasma volume, submaximal exercise demonstrates a continuous rise in level of t-PA Ag. During maximal performance peak levels of u-PA and t-PA Ag do not coincide in time and magnitude, moreover, u-PA Ag rather than t-PA Ag is related to t-PA Act. From these results we conclude that independent mechanisms regulate the exercise-induced plasma levels of u-PA and t-PA.
van den Burg
P J
PJ
Department of Medical Physiology and Sports Medicine, University of Utrecht, The Netherlands.
Dooijewaard
G
G
van Vliet
M
M
Mosterd
W L
WL
Kluft
C
C
Huisveld
I A
IA
D000328:Adult; D000941:Antigens / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000276:immunology; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood*
D000941:Antigens; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator