title: Adenomyoepithelioma of the breast. Report of a case with fine needle aspiration cytology and histologic, immunohistochemical and ultrastructural correlation.
abstract: A case of adenomyoepithelioma of the breast was studied by cytology, histology, immunohistochemistry and electron microscopy. Aspiration cytology of the tumor showed sheets and tubular-type clusters of cohesive, regular polygonal cells with abundant, fairly well preserved, pale, granular to finely vacuolated, clear cytoplasma and a low nuclear/cytoplasmic ratio. The nuclei were small, round and monotonous, with dispersed chromatin and small or inconspicuous nucleoli. Acinus formation was striking: an occasional gland showed a suggestion of an inner layer of cells with denser cytoplasm surrounded by an outer mantle of paler cells. The histologic, immunohistochemical and ultrastructural findings confirmed the two cell populations, constituting an inner epithelial and outer myoepithelial component, both participating in the neoplastic process. The differential diagnoses of various breast lesions with somewhat similar cytologic features are discussed.
authors.affiliation: Department of Pathology, National University of Singapore, National University Hospital.
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Wee
authors.forename: A
authors.initials: A
authors.lastname: Rauff
authors.forename: G C
authors.initials: GC
authors.lastname: Raju
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D002467:Cell Nucleus / Q000473:pathology / Q000648:ultrastructure; D003593:Cytoplasm / Q000473:pathology; D003896:Desmosomes / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009208:Myoepithelioma / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure