Tumor cell interactions with stromal elastin and type I collagen: the consequences of specific adhesion and proteolysis.
Elastin and collagen are abundant fibrous molecules in the stroma. Tumor cells invading the stroma are in contact with fibers of both types much of the time. Both may serve as footholds for the traction required for movement. Elastin has an additional role. Elastin peptides are known to stimulate receptor signaling and chemotaxis, which could explain the morphometric changes (membrane and organelle polarization and cell volume shrinkage) that we have reported for certain tumor cell lines invading elastic lamina. Elastin and its peptides emerge as possible invasion enhancers for some tumor cells. In ongoing work we are screening human tumors that contact elastin (e.g., breast carcinomas) to see if the presence of elastin receptors correlates with early dissemination of metastatic tumor cells.
Parsons
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DF
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D003094:Collagen / Q000502:physiology*; D004549:Elastin / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012680:Sensitivity and Specificity; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology
D011956:Receptors, Cell Surface; C054901:elastin-binding proteins; D003094:Collagen; D004549:Elastin; D010447:Peptide Hydrolases