A genetic analysis of neocortical ectopias in New Zealand black autoimmune mice.
Two experiments investigated the heritability of neocortical ectopias seen in 30-40% of New Zealand Black (NZB/BINJ) autoimmune mice. The first study examined the brains of mice from the NZB x SM/J recombinant inbred (RI) strains. Fifteen RI inbred strains were examined and over half had ectopias suggesting that a major gene was involved in ectopia production. A follow-up experiment comparing the incidence of ectopias among crosses between NZB and control DBA/2 strains showed that the predisposition to develop ectopias in NZB is a recessively inherited trait with incomplete penetrance.
Sherman
G F
GF
Dyslexia Research Laboratory, Beth Israel Hospital, Boston, MA 02215.
Stone
L V
LV
Denenerg
V H
VH
Beier
D R
DR
D000818:Animals; D015551:Autoimmunity / Q000235:genetics*; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D002828:Choristoma / Q000235:genetics* / Q000473:pathology; D003433:Crosses, Genetic; D008040:Genetic Linkage; D051379:Mice; D008811:Mice, Inbred DBA; D011995:Recombination, Genetic