Possibility of targeting treatment for ischemic heart disease with liposome (II).
Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca2+ (4.5 mmol/L), high K+ (8.7 mmol/L) or free radical generating system (FRGS) significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-reperfusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.
Tang
C S
CS
Department of Pathophysiology, Beijing Medical University, PRC.
Su
J Y
JY
Li
Z P
ZP
Zhang
L Z
LZ
Yang
J
J
Qi
M
M
Liu
F A
FA
Tang
J
J
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004337:Drug Carriers; D005609:Free Radicals; D007136:Immunoglobulins; D000922:Immunotoxins / Q000627:therapeutic use*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008081:Liposomes; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000628:therapy*; D009206:Myocardium / Q000276:immunology / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000008:administration & dosage*
D004337:Drug Carriers; D005609:Free Radicals; D007136:Immunoglobulins; D000922:Immunotoxins; D008081:Liposomes; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D011188:Potassium; D002118:Calcium