Appearance of neuropeptide Y-like immunoreactive cells in the rat trigeminal ganglion following dental injuries.
The effects of these injuries on the presence and distribution of neuropeptide Y (NPY)-immunoreactive (-IR) neurones were examined immunohistochemically. In the normal trigeminal ganglion: some perivascular nerves displayed NPY-IR but there were no NPY-IR ganglionic cells. Fourteen days after extraction or pulp exposure of the upper first molar, NPY-IR cells appeared in the maxillary region of the trigeminal ganglion. About 90% of the injury-evoked NPY-IR cells had medium to large diameters (more than 300 microns2 in cross-sectional area). Shallow cavity preparation, however, did not induce the appearance of NPY-IR cells in the trigeminal ganglion. These results indicate the dental injuries alter the primary sensory neurones in the trigeminal ganglion.
Itotagawa
T
T
Department of Operative Dentistry, Osaka University Faculty of Dentistry, Japan.
Yamanaka
H
H
Wakisaka
S
S
Sasaki
Y
Y
Kato
J
J
Kurisu
K
K
Tsuchitani
Y
Y
D000818:Animals; D003737:Dental Cavity Preparation / Q000009:adverse effects; D003782:Dental Pulp / Q000293:injuries* / Q000294:innervation; D003789:Dental Pulp Exposure / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000473:pathology; D009478:Neuropeptide Y / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014081:Tooth Extraction / Q000009:adverse effects; D012668:Trigeminal Ganglion / Q000737:chemistry / Q000293:injuries* / Q000473:pathology
D009478:Neuropeptide Y