title: [Psychotropic profile of essential antidepressants (amitriptyline, imipramine, desipramine, chlorimipramine): comparative study].
abstract: Comparative studies of the therapeutic activity of amitriptyline, imipramine, desipramine and chlorimipramine were studied in a group of 185 patients with endogenous depression. After standard 28-day treatment, the best results were obtained while using amitriptyline (improvement rate 67%, the greatest reduction in the Hamilton Depression Scale scored on 28-day of the treatment). The profile and characteristics of antidepressive action of all the drugs taken into consideration are comparable (including slightly more expressed sedative and deliberative effects of amitriptyline). Desinhibitive influence of desipramine and imipramine was not proved. Neither was tachythymoleptic activity of desipramine found. The study does not support the relation between the antidepressive action profile of tricyclic antidepressants and their influence on reuptake of monoamines (norepinephrine and serotonine).
authors.affiliation: II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii w Warszawie.
authors.forename: I
authors.initials: I
authors.lastname: Koszewska
authors.forename: M
authors.initials: M
authors.lastname: Beresewicz
authors.forename: S
authors.initials: S
authors.lastname: Puzyński
authors.forename: A
authors.initials: A
authors.lastname: Kalinowski
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002997:Clomipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D003891:Desipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D002997:Clomipramine; D007099:Imipramine; D003891:Desipramine
vernacular_title: Badania porównawcze profilu psychotropowego podstawowych trójpierścieniowych leków przeciwdepresyjnych (amitryptyliny, imipraminy, dezypraminy, chlorimipraminy).