We have the key, can we build a lock? A strategy for the elucidation and molecular modelling of the methoxyacrylate (Qo) binding site of cytochrome b.
Wiggins
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ZENECA Agrochemicals, Jealott's Hill Research Station, Bracknell, Berks, U.K.
D000179:Acrylates / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000963:Antimetabolites / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D003573:Cytochrome b Group / Q000737:chemistry* / Q000378:metabolism*; D015195:Drug Design; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D015394:Molecular Structure; D010101:Oxygen Consumption / Q000187:drug effects; D012756:Sheep; D013267:Stilbenes / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000179:Acrylates; D000963:Antimetabolites; D003573:Cytochrome b Group; D013267:Stilbenes