title: Anesthetic management of pheochromocytoma in a long term hemodialysed patient.
abstract: The anesthetic management of a hemodialyzed patient with a dopamine producing pheochromocytoma is described. A 56-years old man underwent surgical procedure the day after hemodialysis. Prior to intervention adrenal cortex hormones were normal as well as other endocrine variables (T3-T4-TSH-cortisol-ACTH-parathyroid hormone); epinephrine and norepinephrine, were in a normal range while dopamine was elevated (185 pg/ml). Preoperatively the patient was alpha-blocked with oral phenoxybenzamine (20 mg/day). A balanced anesthesia was performed (isoflurane and fentanyl). Plasma catecholamines were determined. During the induction of anesthesia and before tracheal intubation phentolamine and labetalol were injected till 3.4 mg and 50 mg total dose respectively. During surgical manipulation a nitroglycerin infusion was started (1.5 gamma/kg/min) and after tumor resection dopamine was given till 15 gamma/kg/min. Hormonal values increased in presence of unchanged hemodynamic parameters, likely due to alpha and/or beta blockade. In this case report our problem was especially fluid replacement after tumor resection, because of renal failure. On the basis of CVP and PCWP values, fluid treatment and dopamine infusion allowed to achieve an adequate preload. A sufficient level of analgesia and an efficient alpha blockade may assure hemodynamic stability also in a so compromised patient status.
authors.affiliation: Department of Anaesthesiology and Intensive Care, Catholic University, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Sollazzi
authors.forename: V
authors.initials: V
authors.lastname: Perilli
authors.forename: M A
authors.initials: MA
authors.lastname: Crea
authors.forename: R
authors.initials: R
authors.lastname: Bellantone
authors.forename: F
authors.initials: F
authors.lastname: Meo
authors.forename: M
authors.initials: M
authors.lastname: Sciarra
authors.forename: R
authors.initials: R
authors.lastname: Pariante
authors.forename: R
authors.initials: R
authors.lastname: Ranieri
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000601:surgery*; D000769:Anesthesia, Inhalation; D004298:Dopamine / Q000378:metabolism; D005440:Fluid Therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism / Q000601:surgery*; D006435:Renal Dialysis
chemical_list: D004298:Dopamine