The analgesic activity of some tuftsin- and tuftsin inhibitor-like fragments of the viral coat proteins.
Antinociceptive activity of seven pentapeptide fragments of human adenovirus type 2 (Ad2) virion proteins: Thr-Val-Pro-Pro-Arg (1), Thr-Arg-Pro-Pro-Arg (2), Thr-Gly-Pro-Pro-Thr (3), Pro-Arg-Pro-Pro-Thr (4), Phe-Val-Pro-Pro-Arg (5), Ala-Arg-Pro-Pro-Ala (6), Tyr-Gly-Pro-Pro-Lys (7)--analogs of known tuftsin inhibitor Thr-Lys-Pro-Pro-Arg, was measured by hot-plate procedure. Also two tuftsin-like fragments of epitopes of HIV-1 and HIV-2: Thr-Lys-Ala-Lys (8), Thr-Lys-Glu-Lys (9), and tuftsin analog Thr-Lys-Asp-Lys (10) were tested. In the control experiments the effects of tuftsin and pentapeptide tuftsin inhibitor were also studied. The peptides 2, 4 and 5 were found to produce very strong analgesia after the icv injection. It was observed that pretreatment with peptide 8 remarkably diminished the antinociceptive effect induced by tuftsin.
Obuchowicz
E
E
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice, Poland.
Słoń
J J
JJ
Klin
M
M
Madej
A
A
Siemion
I Z
IZ
Herman
Z S
ZS
D000260:Adenoviruses, Human / Q000737:chemistry; D000595:Amino Acid Sequence; D000698:Analgesia; D000818:Animals; D001921:Brain / Q000187:drug effects; D002213:Capsid / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000737:chemistry; D015498:HIV-2 / Q000737:chemistry; D007276:Injections, Intraventricular; D008297:Male; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry; D010146:Pain / Q000188:drug therapy*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014405:Tuftsin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology*
D009842:Oligopeptides; D010446:Peptide Fragments; D014405:Tuftsin