title: Patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a psychological challenge.
abstract: Numerous physiological and biochemical factors contribute to the dynamic regulation of the cardiovascular system. This study used a cluster analytic statistical technique to discern patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a laboratory challenge. Fifty hypertensive and normotensive black and white individuals had their beta- and alpha-adrenergic receptor sensitivity determined through agonist infusions. Norepinephrine, epinephrine, blood pressure, and heart rate responses to a standardized mental arithmetic task were also obtained. The cluster analysis identified four subgroups of individuals having distinct patterns of receptor and neurohormonal regulation of end-organ responses. In general, the data indicated that end-organ cardiovascular responses are, in part determined by the sensitivity of adrenergic receptors and the accompanying catecholamine responses. The findings also suggest that for some individuals nonadrenergic factors play a more dominant role than adrenergic mechanisms in determining cardiovascular pressor responses.
authors.affiliation: Department of Psychiatry, University of California, San Diego 92093.
authors.forename: P J
authors.initials: PJ
authors.lastname: Mills
authors.forename: J E
authors.initials: JE
authors.lastname: Dimsdale
authors.forename: R A
authors.initials: RA
authors.lastname: Nelesen
authors.forename: J
authors.initials: J
authors.lastname: Jasiewicz
authors.forename: M G
authors.initials: MG
authors.lastname: Ziegler
authors.forename: B
authors.initials: B
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D004837:Epinephrine / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology*; D011340:Problem Solving / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology
chemical_list: D011941:Receptors, Adrenergic; D009638:Norepinephrine; D004837:Epinephrine