Results of topical treatment of HPV infection in the uterine cervix using interferon beta, 13-cis-retinoic acid and TFX.
Local treatment was administrated to 130 women, in whom colposcopy, cytology and (if the latter was abnormal) histology pointed to HPV infection in uterine cervix. The best results were obtained with 13-cis-retinoic acid (provitamin A) in conjunction with interferon beta (94.2% cured patients), followed by interferon beta in combination with TFX (90% cured patients) and interferon beta administered alone (88% cured patients).
Markowska
J
J
Department of Oncology Medical School in Poznan.
Nowak
M
M
Niecewicz
R
R
Breborowicz
J
J
Wiese
E
E
Zengteler
G
G
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D015474:Isotretinoin / Q000627:therapeutic use*; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000628:therapy*; D012074:Remission Induction; D013949:Thymus Extracts / Q000627:therapeutic use*; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000628:therapy*; D002577:Uterine Cervical Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000628:therapy*
D004338:Drug Combinations; C019108:TFX; D013949:Thymus Extracts; D016899:Interferon-beta; D015474:Isotretinoin