[Highperformance liquid chromatographic assay for lomefloxacin in plasma and its pharmacokinetics in healthy volunteers].
A sensitive and simplified high performance liquid chromatographic procedure has been developed for quantification of lomefloxacin in human plasma. The recovery of lomefloxacin was 95 to 102%. The relative standard deviation was 2.1 to 7.8%. The calibration curve was linear in the range from 0.125 micrograms/ml to 5.012 micrograms/ml with r = 0.9998. The detection limit of the method is 25 ng/ml. The plasma drug concentration-time course after medication conformed to a 1-compartment open model with a first order absorption. Mean t1/2 value was 5.5 h.
Tan
L
L
Department of Instrumental Analysis, Nanjing General Hospital of Nanjing Command.
Xu
D K
DK
Diao
Y
Y
Yuan
Y S
YS
D000890:Anti-Infective Agents; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D024841:Fluoroquinolones; D006801:Humans; D015363:Quinolones / Q000097:blood / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin