title: Change of polyamine level in various tissues of male rats intoxicated with paraquat.
abstract: The effects of paraquat (PQ) on the contents of putrescine (PUT), spermidine (SPD) and spermine (SPM) in the various tissues and organs were examined by means of high-performance liquid chromatography in rats intoxicated with the toxin by three intraperitoneal infusions of PQ for 6 days on every other day. The contents of PUT, SPD and SPM in the large intestine per mg of wet weight showed statistically significant decreases of 39 (P < 0.01), 73 (P < 0.01) and 27% (P < 0.05), respectively. In the liver, however, they showed statistically significant increases of 214 (P < 0.01), 39 (P < 0.05) and 78% (P < 0.01).
authors.affiliation: Department of Pharmacology, Kawasaki Medical School, Okayama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Nagase
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008297:Male; D010269:Paraquat / Q000493:pharmacokinetics / Q000633:toxicity*; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D011073:Polyamines; D013096:Spermine; D010269:Paraquat; D013095:Spermidine; D011700:Putrescine