title: Primary central white matter degeneration in old dogs.
abstract: Degeneration of the central white matter is described in old dogs. The presence of ubiquitin-immunoreactive free granules and intracytoplasmic globules in glial cells and macrophages, together with galacerebroside-immunoreactive precipitates and lipofusion storage, point to the likelihood of a primary myelin degeneration with deposits of non-degraded ubiquitin-protein conjugates and complex galactolipids.
authors.affiliation: Unit of Neuropathology, Hospital Principes de Espana, University of Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Ferrer
authors.forename: M
authors.initials: M
authors.lastname: Pumarola
authors.forename: R
authors.initials: R
authors.lastname: Rivera
authors.forename: M J
authors.initials: MJ
authors.lastname: Zújar
authors.forename: F
authors.initials: F
authors.lastname: Cruz-Sánchez
authors.forename: A
authors.initials: A
authors.lastname: Vidal
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D004285:Dogs; D005260:Female; D005699:Galactosylceramides / Q000276:immunology / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology; D007150:Immunohistochemistry; D008062:Lipofuscin / Q000378:metabolism; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D008578:Meninges / Q000473:pathology; D016253:Microscopy, Immunoelectron; D009410:Nerve Degeneration / Q000502:physiology; D009457:Neuroglia / Q000648:ultrastructure
chemical_list: D005699:Galactosylceramides; D008062:Lipofuscin