title: Extended preservation of the liver with UW solution--is it justifiable?
abstract: The outcome of 228 liver grafts in 208 elective adult recipients was assessed to identify any adverse effects of extending the length of cold preservation with UW solution beyond 12 hr. A total of 114 grafts had been preserved < 12 hr--median 9.5 (group I) and 114 > 12 hr--median 14.5 (group II). Intraoperative blood and blood product usage, graft function, hospital stay, and graft and patient survival were identical in the two groups. Biliary strictures occurred in 5.7% of grafts (8 anastomotic (3 group I, 5 group II; 5 hilar/nonanastomotic: 3 group I, 2 group II). There was no graft or patient loss due to the hilar strictures but 1 patient died following reconstruction of an anastomotic stricture (0.4%). It is concluded that extending the cold preservation to approximately 15 hr does not adversely affect outcome after liver transplantation.
authors.affiliation: Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.
authors.forename: R T
authors.initials: RT
authors.lastname: Padbury
authors.forename: A
authors.initials: A
authors.lastname: Attard
authors.forename: D F
authors.initials: DF
authors.lastname: Mirza
authors.forename: S
authors.initials: S
authors.lastname: Olliff
authors.forename: B K
authors.initials: BK
authors.lastname: Gunson
authors.forename: A D
authors.initials: AD
authors.lastname: Mayer
authors.forename: J A
authors.initials: JA
authors.lastname: Buckels
authors.forename: P
authors.initials: P
authors.lastname: McMaster
mesh_terms: D000241:Adenosine; D000293:Adolescent; D000328:Adult; D000493:Allopurinol; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D005978:Glutathione; D006801:Humans; D007328:Insulin; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011859:Radiography; D011887:Raffinose; D013997:Time Factors
chemical_list: D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose