Congenital microangiopathic haemolytic anemia: a variant of thrombotic thrombocytopenic purpura?
We describe a child with recurrent microangiopathic haemolytic anemia (MAHA) and thrombocytopenia (TCP) who presented on the first day of life. Remission was maintained only by regular infusions of fresh frozen plasma (FFP). This case shows similarities with others described in the literature as examples of thrombotic thrombocytopenic purpura (TTP), although the absence of renal or neurological involvement distinguishes this disorder from classical TTP.
Sartori
P C
PC
Department of Haematology, Birmingham Children's Hospital.
Enayat
M S
MS
Darbyshire
P J
PJ
D000745:Anemia, Hemolytic, Congenital / Q000175:diagnosis* / Q000628:therapy; D001803:Blood Transfusion; D003937:Diagnosis, Differential; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010949:Plasma; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000151:congenital / Q000175:diagnosis* / Q000628:therapy; D012008:Recurrence