IGF-II producing hepatic fibrosarcoma associated with hypoglycemia.
A 67-year-old male was admitted with the complaint of weakness at hunger early in the morning, when blood glucose was less than 40 mg/dl. The abdominal ultrasonogram and computerized tomogram demonstrated a huge tumor in the right liver lobe. Hypoglycemia disappeared after transcatheter arterial embolization. Then hepatic lobectomy was performed. The tumor was histologically shown to be a fibrosarcoma. Insulin-like growth factor-II was intensely stained in the Golgi area of the tumor cells, suggesting its role in the mechanism of hypoglycemia.
Kotani
K
K
Second Department of Internal Medicine, Kobe University.
Tsuji
M
M
Oki
A
A
Kashihara
T
T
Yamada
K
K
Kawakami
F
F
Tako
H
H
Okuno
G
G
Hizuka
N
N
Aiba
M
M
D000368:Aged; D004621:Embolization, Therapeutic; D005354:Fibrosarcoma / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000628:therapy; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000628:therapy
D007335:Insulin-Like Growth Factor II