[Use of time-of-flight mass spectrometry with ionization division fragments of californium-252 for studying the mechanisms of action of drugs on DNA and its components].
Using soft-ionization mass spectrometry (252-Cf particle desorption mass spectrometry, PDMS) a minor adduct of anticancer drug prospidine and deoxyguanosine-5-phosphate (pdG) has been found. It has been shown experimentally that PDMS is very useful for study of biological mixtures as well as mechanisms of interactions between drugs and biomolecules.
Sukhodub
L F
LF
Grebenik
L I
LI
Chivanov
V D
VD
D002142:Californium / Q000737:chemistry*; D004247:DNA / Q000187:drug effects*; D003848:Deoxyguanine Nucleotides / Q000494:pharmacology*; D007477:Ions; D013058:Mass Spectrometry / Q000379:methods; D011447:Prospidium / Q000494:pharmacology*
D003848:Deoxyguanine Nucleotides; D007477:Ions; C007257:2'-deoxyguanosine 5'-phosphate; D011447:Prospidium; D004247:DNA; D002142:Californium
Primenenie vremia proletnoĭ mass-spektrometrii s ionizatsieĭ oskolkami deleniia kaliforniia-252 k izucheniiu mekhanizmov deĭstviia lekarstvennykh preparatov na DNK i ee komponenty.