The role of HLA-DQ antigens in the induction of cytotoxic T lymphocytes.
Investigating three pairs of HLA-DR (DRB1) identical unrelated persons on the induction of cytotoxic T lymphocytes (CTL) it was found that HLA-DQ antigens provided slight proliferative stimulus which was, however, sufficient for the generation of CTL. The results indicate that the HLA-DQ antigens do play a similar role in clinical bone marrow transplantation as the HLA-DR specificities.
Porubská
S
S
Institute of Immunology, Faculty of Medicine, Comenius University, Bratislava.
Buc
M
M
Bencová
M
M
Sausová
E
E
D016026:Bone Marrow Transplantation / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006683:HLA-DQ Antigens / Q000502:physiology*; D006684:HLA-DR Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens