[Renin-angiotensin system and atherosclerosis].
Based upon literature the renin-angiotensin system involvement in the pathogenesis of atherosclerosis has been discussed. Angiotensin II leads to the increased production of growth factors such as PDGF, TGF-beta, FGF and extracellular matrix proteins. There are evidences that angiotensin II stimulates expression of egr-1, c-jun, c-fos and c-myc oncogenes in vascular smooth muscle cells. Proliferation of aortic smooth muscle cells in response to the injury can be reduced by inhibitors of renin-angiotensin system what supports the hypothesis that angiotensin II can contribute to the pathogenesis of atherosclerosis.
Stajszczyk
M
M
Katedra i Zakład Biochemii i Chemii Slaskiej AM, SKatowiaicach.
Gmiński
J
J
D000804:Angiotensin II / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology*; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology*
D000804:Angiotensin II
Układ renina-angiotensyna a miazdzyca.