Exacerbation of psoriasis due to interferon-alpha treatment of chronic active hepatitis.
Interferon-alpha is an immune modulating drug which is indicated for the treatment of chronic viral hepatitis B and C. Several previous reports have suggested an association between treatment of patients with interferon-alpha and the development or exacerbation of autoimmune diseases. We report two patients with chronic viral hepatitis in whom treatment with interferon-alpha was associated with dramatic worsening of previously diagnosed psoriasis, necessitating discontinuation of the drug.
Georgetson
M J
MJ
Department of Gastroenterology and Hepatology, Guthrie Clinic, Sayre, Pennsylvania.
Yarze
J C
JC
Lalos
A T
AT
Webster
G F
GF
Martin
P
P
D000328:Adult; D006509:Hepatitis B / Q000188:drug therapy*; D006526:Hepatitis C / Q000188:drug therapy*; D006521:Hepatitis, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced*
D016898:Interferon-alpha