[Low molecular weight heparin inhibits raised intraocular pressure following intracameral administration of sodium hyaluronate].
The effect of low molecular weight (LMW) heparin on increase of intraocular pressure following intracameral administration of sodium hyaluronate (HA) was investigated in rabbit eyes. In each case, the aqueous humor of one eye was replaced with HA and a balanced salt solution (BSS) containing 10.0 IU/ml of LMW heparin, and as a control the aqueous humor of the fellow eye was replaced with HA and BSS containing no LMW heparin. Intraocular pressure was measured for 24 hours following the replacement. As a result, significant increase of intraocular pressure was observed at 6 hours after the injection in the eyes administered HA and BSS. In comparison, no significant increase of intraocular pressure was observed in the eyes injected with HA and LMW heparin. When the concentration of LMW heparin was less than 2 IU/nl or the LMW heparin was heat-deactivated, the HA-induced increase of intraocular pressure was not inhibited. The results indicated that LMW heparin inhibits increase of intraocular pressure following intracameral administration of HA possibly by an inhibitory effect on intraocular fibrin exudation, and the increase of intraocular pressure is probably associated with interaction between fibrin and HA.
Kondo
H
H
Department of Ophthalmology, School of Medicine, Fukuoka University, Japan.
Hayashi
H
H
Oshima
K
K
D000818:Animals; D000867:Anterior Chamber; D001082:Aqueous Humor; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007429:Intraocular Pressure / Q000187:drug effects*; D009798:Ocular Hypertension / Q000139:chemically induced / Q000517:prevention & control; D011817:Rabbits
D006495:Heparin, Low-Molecular-Weight; D006820:Hyaluronic Acid