Concentration of interleukin-1 beta correlates with prostaglandin E2 and F2 alpha in human pre-ovulatory follicular fluid.
To investigate the role(s) of interleukin-1 beta (IL-1 beta) in human ovarian function, we measured the concentrations of IL-1 beta, prostaglandins (PGs) and steroids in follicular fluid of 90 stimulated ovaries, with reference to oocyte maturation. Concentrations of IL-1 beta were significantly higher in the follicles from which mature oocytes were recovered than in follicles from which oocytes could not be recovered (P < 0.05). IL-1 beta concentrations also increased in association with oocyte maturation. Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P < 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P < 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone. Follicular fluid IL-1 beta might contribute to prostaglandin-induced oocyte maturation and ovulation.
Watanabe
H
H
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
Nagai
K
K
Yamaguchi
M
M
Ikenoue
T
T
Mori
N
N
D016922:Cellular Senescence / Q000502:physiology; D015237:Dinoprost / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D005498:Follicular Phase / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D009865:Oocytes / Q000166:cytology; D011374:Progesterone / Q000378:metabolism
D007375:Interleukin-1; D011374:Progesterone; D004958:Estradiol; D015237:Dinoprost; D015232:Dinoprostone